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    <name>F4F120_MICM1</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="AEB42674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="49" mass="5946" checksum="7673581DE184C4D6" modified="2011-06-28" version="1">MVEKEREQLLLPDGRRPSGWARGKVGRDEMLWLQVAGDRRRWYRYEIDA</sequence>
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<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
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    <name>F4F1T4_MICM1</name>
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        </recommendedName>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="1985371at2"/>
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    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
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        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
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        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_sf"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="231"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="584" mass="62789" checksum="80D182B26D4DBC4F" modified="2011-06-28" version="1">MAAQEYLQPALAGLDPAVDGVDPALPLYATTFVVVDLETTGGAPDGGGITEIGAVKVRGGEELGVLATLVNPGVPIPPFITVLTGITEAMLLPAPSIEQVLPSFLEFVSDAVLVAHNAPYDVGFLKAACARHGYRWPNPRVLDTAALARRVLLRDEVPNRKLGTLAAYFRAATTPTHRALDDARATVDVLHGLIGRLGGHRVDTIGEAIEFARAVTPTQRRKRHLADGLPRSPGVYIFRAADDRPLYVGTSRDIATRVRSYFTAAEKRARISEMLAAAERVEALECAHSLEAEVRELRLIGAHAPPYNRRSKYPERVVWLKLTDGPYPRLSVVREISPDDRAYLGPFSSRRAAELAAAGFHDAVPLRQCTHRLSLRTVTPACALAELGRCLAPCEHRITPQEYDAVAVTPFAEATTGDVKPVVDALLARIEALAAGQRYEEAAVLRSRLAAVLRATVRMQRLAALTGIAEVAAARPAEHGGWELALVRHGRLAGAGVSPPGVHPRPTLATMRATAETVSAGHGPVPAATPEESERILSWLERPETRLVEMSAGWASPVSGAGRFRDLLTKAENAASHQLWSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Z1</accession>
    <name>F4F1Z1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative branched chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_03270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03270"/>
    <dbReference type="EnsemblBacteria" id="AEB47738">
        <property type="protein sequence ID" value="AEB47738"/>
        <property type="gene ID" value="VAB18032_03270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03270"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_2_1_11"/>
    <dbReference type="OMA" id="LIWDFTI"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000008308">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="291" mass="30380" checksum="973637FB321B5E85" modified="2011-06-28" version="1">MGDLGQILLGGVTTGSLYALFLLGVLIVFQVSKSMNFAYGQVGMIAAFSAWFFYSEQGLPVPVALVIGVLIAVIVNSAIDFAAIRRIPAGRPGLDLVVTLGIFLLITAVMQQLIDANAHTFVSLGADTRTEVAGVVVSMSDGIVIGLTVVTVLAAYLLLNRTSLGTSLRASAEDAGIAQAAGVNVRALRTATWAVAGLIAAVVAILVASRLSVDAFYMTPFLIKAFIAGMIGGLDRFWLPLVVAVALGVYESLAVYLLGASAGTPAVFLLIIVVLALVPKRFVNERNEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F254</accession>
    <name>F4F254_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenazine biosynthesis protein phzf family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
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    <dbReference type="STRING" id="263358.VAB18032_08125"/>
    <dbReference type="EnsemblBacteria" id="AEB42743">
        <property type="protein sequence ID" value="AEB42743"/>
        <property type="gene ID" value="VAB18032_08125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08125"/>
    <dbReference type="eggNOG" id="COG0384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_0_0_11"/>
    <dbReference type="OMA" id="IVNGMSQ"/>
    <dbReference type="OrthoDB" id="1468060at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="29742" checksum="FF49FDF3EB164F30" modified="2011-06-28" version="1">MSTLAYEIVDVFTARPYAGNPLAVVFGAEGLATEQMQALAREFNLSETVFVLPATQVGVTYRARIFTPVEELPFAGHPSVGAAVTASRRGLFEPGQVTQECGAGVLPIEVTESGATLTGGMPTLGPELDPEPLLEMAGLAAGDHVGPAPRVAGCGLEFPFLPVRPEALARAQVDPLAARRYGIEHVSVFSWDAATQTAYARVFVPGLGVPEDPATGSAALGLGVWLVASGLLPADERSSYTVRQGVEMGRPSSLACTVTAAGGTVLGATVSGQVMAVAKGEILVPPFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F268</accession>
    <name>F4F268_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08195"/>
    <dbReference type="EnsemblBacteria" id="AEB42757">
        <property type="protein sequence ID" value="AEB42757"/>
        <property type="gene ID" value="VAB18032_08195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08195"/>
    <dbReference type="eggNOG" id="ENOG5030GNI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118602_0_0_11"/>
    <dbReference type="OMA" id="WMPWPLP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="22437" checksum="E8146470555A898C" modified="2011-06-28" version="1">MRPPDLMHAESRCPDCGPVAPLHVPENIGAEIVASVVDRIQAAQPGQPAVPLWCPWPLPPGWTTTGVAWAGDDRLGVRATAVACAGPEPLGGGPADLVFVAEEPGVGLGARYAGVPGPDAGPELAEALTEPGPGHPGHVGRAGIKVAGHPTPLWLINSLTDRSAYAGEARGLWLYAIAWPASAGHLLAEDVVLHDLVEWMPTELVYGAPSPYLHGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2C8</accession>
    <name>F4F2C8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732667.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14440"/>
    <dbReference type="EnsemblBacteria" id="AEB44000">
        <property type="protein sequence ID" value="AEB44000"/>
        <property type="gene ID" value="VAB18032_14440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14440"/>
    <dbReference type="eggNOG" id="ENOG50330B5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157972_0_0_11"/>
    <dbReference type="OMA" id="TGVWPAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025329">
        <property type="entry name" value="DUF4235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14019">
        <property type="entry name" value="DUF4235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="90" mass="9254" checksum="0E7EABC5F8B569FD" modified="2011-06-28" version="1">MSKGIGKAAYRPVGVLMGIAAGAIAGSIFRQVWKMTAGDGEAPNATDEDRRWGEILAAAALQGAIFAVVRAAVDRGGAVGVRRLTGSWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2J3</accession>
    <name>F4F2J3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732732.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14765"/>
    <dbReference type="EnsemblBacteria" id="AEB44065">
        <property type="protein sequence ID" value="AEB44065"/>
        <property type="gene ID" value="VAB18032_14765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14765"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_3_0_11"/>
    <dbReference type="OMA" id="HATSSCM"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="172" mass="18315" checksum="A99229E9B6D8D1EA" modified="2011-06-28" version="1">MTQTQDATRSRTFSWSDPSINAAQIGRRSGLDLLRAMVAGELAAPPVMHLIDMASMTAEEGRVVVELQPQEFHYNPLGTVHGGVISTLLDTAAACAVHSTLPAGIGYTTLDLNVKFLRPVTVNSGTLRCEGTVLQQGRRTALAEARLTDGRDRLVAHATSSCLLLPLEPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2R1</accession>
    <name>F4F2R1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733980.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21130"/>
    <dbReference type="EnsemblBacteria" id="AEB45326">
        <property type="protein sequence ID" value="AEB45326"/>
        <property type="gene ID" value="VAB18032_21130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21130"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040294_0_0_11"/>
    <dbReference type="OMA" id="IMPNHEV"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="437"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="542" mass="58313" checksum="163B2072D8013C47" modified="2011-06-28" version="1">MQLPARDIVREYTEAVFRRARVPMEPLNFEVDWGDQPSRHTAYPAARTVPLPTRLPELATLRDLFTGASPSAPTGWSMTRLAALLRLSYGVLDRRMTVNWNQDVAKRAHFEHAVWGRGTASGGGMYPVEVHLVAGASAPLLPGVYHYDTGRHVLQRLLVGDVSSNVRAGLAGPEDTDSFLVASIRFWKNSFKYNSFCYHVVTQDLGALLGSWELLASALGVPLRRLLCFDPEPMDRLLGFDSDEQSVFAVVPLSWHTDTGAGDPAVPTRAGDGEVTPATVQVGHAAHERSQRVRRFPAVTAVHRAAATAPAVDPAAVLDAAPRPLPGDPVALPEPRLDLLDRPLSAVLTGRSSSFGRFRRPPELTVAELGTTLAFAAAGRPHPADAGLPADAAALTRLWVFANHLDGLPAGGYAYCARRHALLPAASEPDIGMSAFLQQQYFLTNYTMGQVGAVLAVSGRLDAVLDAYGPRGYRILNAEIGAVAQRVYCATTAQRVGCGAVLGFDNVSMDTALGLDGSDERTVLFLLLGRNSDAVADLEYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2R4</accession>
    <name>F4F2R4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21145"/>
    <dbReference type="EnsemblBacteria" id="AEB45329">
        <property type="protein sequence ID" value="AEB45329"/>
        <property type="gene ID" value="VAB18032_21145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21145"/>
    <dbReference type="HOGENOM" id="CLU_2526576_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="84" mass="9382" checksum="9465752E35D29823" modified="2011-06-28" version="1">MLLQLDEVQLQQLDVLQLEQLDVLVLLLQMSIRSADRSAMSSTSNVSVCRSRSSLRTESASEPDVGGCVGTDVSLSRDRRQWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2U3</accession>
    <name>F4F2U3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27406"/>
    <dbReference type="EnsemblBacteria" id="AEB46554">
        <property type="protein sequence ID" value="AEB46554"/>
        <property type="gene ID" value="VAB18032_27406"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27406"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023239_0_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307355" evidence="2">
        <location>
            <begin position="19"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="572" mass="61031" checksum="01E2E8C7C0B4AF81" modified="2011-06-28" version="1">MIAAGLLLAGALPGTASAAEPDPRVGLGAGWLDAETAISNLEHLANRPKPAGFVDPNNPGAGSFIASDLGFGDKYAVLGNYNGFNIVDISKPADPTLVTSVVCPGGQGDPSVFGNLVFMSVEETRGRVDCGTNSSVGTRFQGVRIFDISDVRNPVQVAAVQLCRGSHTHTVVTDPKDKNHVYIYNSGTAGVRPANTMEGCNNNPADGDNPSRWRIEVIKVPLAAPHQAAVVNAARLFADPTTGRIDGLQNGPTTPRHPSGGTWSPSPNTNTCHDITAYPEIGLAAGACQGNGILVDISDPANPVRIDEVSDPNFAYWHSATFNNDGTKVIFTDEWGGGSGARCRDIDQPEWGANAIFDIVDGKMEFRSYYKLPAPQTTAENCVAHNGSLIPVPGRDIMVQAWYQGGLSVFDFTDSTNPREIAFFDRGPIAPDRIVSGGYWSVYWYNGNLYGNEMARGLDVFALKPSQHLSAAEITAASQVKLAEFNAQHQPKIEWTPSFAVARAHYDQAVRANTLGKQMTSQVDKFLERAEKFAAEGKRSAAVAQLGAISNQISGAEHQALKQAILDLRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2X5</accession>
    <name>F4F2X5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735236.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27566"/>
    <dbReference type="EnsemblBacteria" id="AEB46586">
        <property type="protein sequence ID" value="AEB46586"/>
        <property type="gene ID" value="VAB18032_27566"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27566"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_1_11"/>
    <dbReference type="OMA" id="HLRRMFS"/>
    <dbReference type="OrthoDB" id="1748122at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="288" mass="31957" checksum="447DFF0765E29A47" modified="2011-06-28" version="1">MLERLNQAMEHLEQHLDRPVEIAELARIAVTSEYHFRRLFSALAGIPLSEYVRRRRLTMAAAEVVSGERTLLDIAIRWGYGSAEAFARAFKAVHGVGPGEARRTKSPLHAQPRVSFRLVVEGSSSMRYRIVRKDAFQLAGRKARMPLVHEGMNPAVVAFVKSIEPATRERIEALSDQEPAGIVNVSDGLTGNREEGTELDYWYGVVTGADVPGDLDVLPVPAGDWAVFEVAGEFPAAVQYLWRDVFTQWFPSNPYRSRPGPEISRTTVSADGTHAEAELWIPVEPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Z4</accession>
    <name>F4F2Z4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735255.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27661"/>
    <dbReference type="EnsemblBacteria" id="AEB46605">
        <property type="protein sequence ID" value="AEB46605"/>
        <property type="gene ID" value="VAB18032_27661"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27661"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097062_2_1_11"/>
    <dbReference type="OMA" id="ESFLDFH"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="173" mass="19174" checksum="C82BAC6E30DFE6C9" modified="2011-06-28" version="1">MAEIAIDPTLGPVVNRTAGEREVLESFLDFHRTVLLRKLHGLSDADAARRLVPSATTVAGLVKHLTEIERNWFHILLEPSPGETFPTTDEAALASFTLAEDDTVERLAADYQQVCARSREIVARFDLDHVVPHPQLGEVSVRWILVHMIEETARHVGHADILRELTDGTTGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F303</accession>
    <name>F4F303_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735264.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27706"/>
    <dbReference type="EnsemblBacteria" id="AEB46614">
        <property type="protein sequence ID" value="AEB46614"/>
        <property type="gene ID" value="VAB18032_27706"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27706"/>
    <dbReference type="HOGENOM" id="CLU_2072151_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="118" mass="12067" checksum="BA45BF5E55AE96A5" modified="2011-06-28" version="1">MSHLPVDLDHAIGLGLLSLVIGAISGTALILLIPSTPLLIVFLAILPPYLELHVAGVRHRWWALGAGTAAGVPAGLGINALLEASIGAQWATLIGILVGSAIGILTHAAVTHLPSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F365</accession>
    <name>F4F365_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736476.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03810"/>
    <dbReference type="EnsemblBacteria" id="AEB47844">
        <property type="protein sequence ID" value="AEB47844"/>
        <property type="gene ID" value="VAB18032_03810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03810"/>
    <dbReference type="eggNOG" id="ENOG5030IIT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191581_0_0_11"/>
    <dbReference type="OMA" id="CWISPFK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="82" mass="9493" checksum="ECACF4C3D43EE2DC" modified="2011-06-28" version="1">MDPLTIAAITLTTIPTLITLGYGILCWISPFKTCRRCAGTGQTTTRFLRRPRACRRCDRGMRLRTGRRVYNVFHRLRAEAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3G1</accession>
    <name>F4F3G1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome replication initiation inhibitor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731556.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08835"/>
    <dbReference type="EnsemblBacteria" id="AEB42885">
        <property type="protein sequence ID" value="AEB42885"/>
        <property type="gene ID" value="VAB18032_08835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08835"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063829_0_1_11"/>
    <dbReference type="OMA" id="QQWKLDS"/>
    <dbReference type="OrthoDB" id="951478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017685">
        <property type="entry name" value="ArgP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03298">
        <property type="entry name" value="argP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="298" mass="32006" checksum="DB0BC5686AFE207F" modified="2011-06-28" version="1">MSGLDSAQLRTLAAVVSEGSFEAAGRLLHVTPSAVSQRIKALEEAVGQVLVRRQRPCDATEAGRPLLRLAGQLALLEREALADARGPLGGDPGRTRVAVVVNADSLATWFPAALARLPAPPELSFDIRQDDQDHSAELLRAGAVMAAVTAQREAVQGCRVRPLGAMRYRALAAPSALRRWFADGLTRSALAAAPVVLFDRRDRIQHRFLRTLTGRTVDPPVHYVPSVPAFSAAIRLGLGWGMVPEQIAADDLDSGRCVDLAPGRVVDIPLYWQHWRLDSAVLTALTTAVCAVAAETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3V0</accession>
    <name>F4F3V0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734054.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21505"/>
    <dbReference type="EnsemblBacteria" id="AEB45401">
        <property type="protein sequence ID" value="AEB45401"/>
        <property type="gene ID" value="VAB18032_21505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21505"/>
    <dbReference type="eggNOG" id="ENOG502ZDJ8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="AFEPASW"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="6701" checksum="66FAB2DDA53CEDF3" modified="2011-06-28" version="1">MADLTGAKWRKSTRSGSNGGDCVEVAGNLPGLVAVRDSKDPGGPALIFAPTMWASFLQATKTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3W1</accession>
    <name>F4F3W1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21560"/>
    <dbReference type="EnsemblBacteria" id="AEB45412">
        <property type="protein sequence ID" value="AEB45412"/>
        <property type="gene ID" value="VAB18032_21560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21560"/>
    <dbReference type="eggNOG" id="ENOG5031ZQG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331468_0_0_11"/>
    <dbReference type="OMA" id="RELPAWM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="206" mass="22610" checksum="F24943B20A458047" modified="2011-06-28" version="1">MSVIALDRLKADARWRTLFDGPGVAESELPPEILPAAIDYCRNVQTGEPKPLARLVRADGPFATDRGLRELPAWMMYPAKRRWPFIALDPDFQRRMTWCPPGLTATGHPESVLGDDHRTLTYRFTGTPRQYADYPCAEVFETETAVLVKPVEVPLDGPDGVRLAYAEEREVVVRLAAPLGNRALICLGHGPGSATFGSPVAVITSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4J9</accession>
    <name>F4F4J9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09195"/>
    <dbReference type="EnsemblBacteria" id="AEB42957">
        <property type="protein sequence ID" value="AEB42957"/>
        <property type="gene ID" value="VAB18032_09195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09195"/>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="TDARWRK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="66" mass="6971" checksum="EF0E83B22DC1DD1E" modified="2011-06-28" version="1">MDMTDARWRKSSYSGSNGGSCVEVADNLTGVVLVRDTKDRDGGTLAFTPTAWASFVTLAKTVSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4K2</accession>
    <name>F4F4K2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ppx/gppa phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731631.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09210"/>
    <dbReference type="EnsemblBacteria" id="AEB42960">
        <property type="protein sequence ID" value="AEB42960"/>
        <property type="gene ID" value="VAB18032_09210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09210"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_1_2_11"/>
    <dbReference type="OMA" id="IGCVRMT"/>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="29"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="313" mass="32800" checksum="528339BD639DD135" modified="2011-06-28" version="1">MAAIDCGTNSIRLLVADLPDPSAGSTAPLVDLTRRMEIVRLGQGVDATGRLAPEAIERTRVALTDYAADIAKLGAERVRMCATSATRDAENAADFRAMVEQTLGVPPEVVSGDEEARLSFTGAVRGLPADAQSPYLVVDIGGGSTEFVVGSRDAGVHAAISMDIGCVRMTERHLHGDPPSLDEVAAAQADVAVAVDRALTAVPGREAATLVGLAGSVTTVVAIAQELTEYDPTRIHHARVSYDRVAEVTARLLTLTREQRLAIPVMHPGRADVIGAGALVLRVIMERAGMDSVVASEHDILDGIAWSLAATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4M8</accession>
    <name>F4F4M8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uspa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732835.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15290"/>
    <dbReference type="EnsemblBacteria" id="AEB44170">
        <property type="protein sequence ID" value="AEB44170"/>
        <property type="gene ID" value="VAB18032_15290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15290"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OMA" id="HIPAFYY"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="153"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="30747" checksum="125C3BA0569FCAA5" modified="2011-06-28" version="1">MSSNNAPVVVGVDGSETALHAVRAAAREAAYRQRPLRVVHAFIWPLMRVPLGPAPGAPADAGLRNQAEQFVAEAVAEATKVAPEVSVTGAVVHGAAPAVMLAEADNAALLVLGSRGLGGFAGLLLGSVAVQLSARASCPVLVVRGEQRADGPVVVGVDGSPASDEAIGFAFEEAARRDTELVAVHSWLYPAPAGPGDILPLVYDLDAFREQEEKVLADAVARWSPRYPKVPVRQLLVRGSPARALVEQSRDAQLVVVGARGRGALAGLLLGSVSHAVLHHADTAVVVVREPRTVDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F504</accession>
    <name>F4F504_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_21965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734146.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21965"/>
    <dbReference type="EnsemblBacteria" id="AEB45493">
        <property type="protein sequence ID" value="AEB45493"/>
        <property type="gene ID" value="VAB18032_21965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21965"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="KGMQMKA"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="299" mass="31929" checksum="3D0D736A429774AF" modified="2011-06-28" version="1">MTGTEFALRTDGVGKRYRKGWALRDCTLALPAGGVIALVGPNGAGKTTLLRLVVGLLAPSTGTVEVLGHDVTASTPQTLSRVGFLAQDHPLYKRFTVAEMLRFGRACNLRFDQGLAERRLAKLGIPLDRRAGTLSGGQQAQVALALALAKRPDLLVLDEPVASLDPLARHEFLQVLMGAVAEGGVTVLFSSHVVHELERVCDHLVVLNQGRVTLTGDIDTLLAEHRLLVGPRTATDLDRAGTVVQAVHSDRQTTLLVRDGGLPAAPGWQAQPVALEELVLAYLRRSSEPSGTVWSEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F526</accession>
    <name>F4F526_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735358.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28186"/>
    <dbReference type="EnsemblBacteria" id="AEB46708">
        <property type="protein sequence ID" value="AEB46708"/>
        <property type="gene ID" value="VAB18032_28186"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28186"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083309_0_0_11"/>
    <dbReference type="OMA" id="VDRHWNL"/>
    <dbReference type="OrthoDB" id="705269at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="266" mass="28909" checksum="B40FD16959AF88DD" modified="2011-06-28" version="1">MTATVPALSVGPALRRWREARRLSQLEMAARADISTRHLSFVETGRSRPSPEMVLRLAEHLDLPLRERNRLLLAAGYAPAYPQTALTAPRMASARAAVRQVLAGHEPYPAVVVDCSWQMVDANQSLTIFTDLVAPDLLAPPVNVLRVSLHPDGLAPHIANLGQWRAHLLARLARQVELAGDAGLAALDGELRGYPSDGPEPDVELPGPGDIVVPLRLRHDGGELAFISTIATFGTPLDVTLAELSIESFYPADERTAAVLRERSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F536</accession>
    <name>F4F536_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735368.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28236"/>
    <dbReference type="EnsemblBacteria" id="AEB46718">
        <property type="protein sequence ID" value="AEB46718"/>
        <property type="gene ID" value="VAB18032_28236"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28236"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_6_11"/>
    <dbReference type="OMA" id="GREVMYR"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="99" mass="10415" checksum="27C1A1A4F6AF15E9" modified="2011-06-28" version="1">MSSESGYDAYEGASELLRALSAPIRLAIVSELAGGERCVHELVDKLGVAQPLVSQHLRVLRGAGVVRGSRRGREIAYALVDEHVAHIVADAVSHAGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5A4</accession>
    <name>F4F5A4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736583.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04350"/>
    <dbReference type="EnsemblBacteria" id="AEB47952">
        <property type="protein sequence ID" value="AEB47952"/>
        <property type="gene ID" value="VAB18032_04350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04350"/>
    <dbReference type="eggNOG" id="COG1260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_11"/>
    <dbReference type="OMA" id="GTKEWAD"/>
    <dbReference type="OrthoDB" id="669352at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017815">
        <property type="entry name" value="Myo-inos-1-P_Synthase_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03450">
        <property type="entry name" value="mycothiol_INO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="191"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="359" mass="38998" checksum="C1857A878256E9AD" modified="2011-06-28" version="1">MGSVRVAIVGVGNCASSLVQGVEYYRNADPNDRVPGLMHVTFGDYHVSDVQFVAAFDVDAKKVGMDLAEAIVASENNTIKLCDVPPTGVTVQRGPTFDGLGQYYREIVEESDAAPVDVVKALRDAQVDVVVSYLPVGSEQADKFYAQAAIDAGCAFVNALPVFIASDPEWAQKFTDAGLPIVGDDIKSQVGATIVHRALAKLFEDRGVELLRTYQLNFGGNMDFMNMLERNRLVSKKISKTQSVTSQVPHEMAKSDVHIGPSDHVPWLDDRKWAYIRLEGRSFGDTPLNAELKLEVWDSPNSAGVIIDAVRAAKIALDRKIGGPILSASSYFMKSPPVQYADHDAHAAVEAFIAGEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5C8</accession>
    <name>F4F5C8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaA</name>
        <name evidence="15" type="ordered locus">VAB18032_04470</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736607.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04470"/>
    <dbReference type="EnsemblBacteria" id="AEB47976">
        <property type="protein sequence ID" value="AEB47976"/>
        <property type="gene ID" value="VAB18032_04470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04470"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_2_0_11"/>
    <dbReference type="OMA" id="RPVENEQ"/>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="301"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="14">
        <location>
            <begin position="513"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="195"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="309"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB47976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="607" mass="66902" checksum="9C43ABF4F509C2E3" modified="2011-06-28" version="1">MAGTTDLAAVWTATTDELADEIISAQQRAYLRLTRLRAIVEDTVLLSVPDAFTRDVIESRLRPAITEALTRRLGRPIQVAVTVRLPEDGRTEGTVYHSAAETGPAVHDGGPVDYAGPAESGSTTDDRQQLPLIPEQHHPHRFDRPVPETPHVADGGPRTGPPVADGQETLFGAAFVEPGRSGGEARRQPQRLGFADQAGQLDPPNPGPRGFAGRYGDDPGVSPRDQHVIRSLPGDGGGTDSGPGRSGTDHRSRDDRRLPAGADSGGNRLNPKYMFETFVIGSSNRFAHAASVAVAESPAKAYNPLFIYGSSGLGKTHLLHAIGHYATTLGNARSVRYVSTEEFTNDFINSLRDDKTSAFQRRYRDVDILLIDDIQFLENRERTQEEFFHTFNTLHNANKQIVITSDRSPKQLATLEDRLRTRFEWGLLADIQPPDLETRIAILQKKAAQERLYAPPDVLEFIASRVSNSIRELEGALIRVTAFASLTRSSVELSLAEEVLRDFIPDGAGPEITADQIMVSTADYFGVSLEDLRGHSRSRVLVNARQVAMYLCRELTDLSLPRIGQAFGGRDHTTVMHADRKIRQQMAERRSLYNQIAELTNRIKQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5K0</accession>
    <name>F4F5K0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF559 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09570"/>
    <dbReference type="EnsemblBacteria" id="AEB43032">
        <property type="protein sequence ID" value="AEB43032"/>
        <property type="gene ID" value="VAB18032_09570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09570"/>
    <dbReference type="eggNOG" id="COG2852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052626_5_2_11"/>
    <dbReference type="OMA" id="HSGRVAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="206"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="31297" checksum="8CB7D8DBBE95AE5B" modified="2011-06-28" version="1">METLMRTLTARRLRTRLSREELRRVRRGVYSDQPVDDEDELRALLLCLPAGTMLARQTAARRHGFGVLRDDLVHVQVPPSVPKPRLPGLVVHHCVLPVQPVLVQGLPCVPAARCAIDLARTVSRFDALPVLDSALRAEAVTPDDLLAEVSAHRGLRGVRQARELVPLADGRAECRQESQLRLVLLDGRLPPPEPQLWVPDRYGALRYRLDLGYRERRVGIEYDGLTHLDRDALRYDRERVNWLDAQGWRMRYFTDRDLYRRPAHIVATIRAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5P2</accession>
    <name>F4F5P2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15715"/>
    <dbReference type="EnsemblBacteria" id="AEB44255">
        <property type="protein sequence ID" value="AEB44255"/>
        <property type="gene ID" value="VAB18032_15715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15715"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444680_0_0_11"/>
    <dbReference type="OMA" id="HLAPTTW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="648" mass="68009" checksum="6D7959BE7B4C425C" modified="2011-06-28" version="1">MSSGGPQLSIDLSSPTAIAATIGRSGARIPVLVGGRHLLPTGIAIDPTGHRYYGIDPTAAQSLPTGYRFVADPVTLLTTPPPPTESGPVDGVDVLAGLLRHLTDHAAHQVGAPITALTLTIPTGWGPRRRGLLTDAATRAALPPPVLVTAPAALAAYATTLGLHAPPGSCLLTCHTDQRPATLTVLQAHPDGYTELATQPVGQPHDLDQILTHHVITTATSDDDPLRDALHHPDTDTAALHDAVRQARHTLATHDRAPILLPAPRPPAVITRADVTTAAQPLLDRIPTAVTDILDAADVDRAHLTAVIVRHTGPVPGLVDTLTTATATTTGAVDQPHALADGALTLTTRHHHTATAATTQLPRIRLRITDLITAVLLGGCSLALLLHAVHNADIYKLEGRIIDVVVSMPQLGAAGALAALAAYAVAHLAPTTWLAGPPTTNEPTTGRLIRHAYLTAAIAGPTTAALYGLAVGTALQYPYRPFLTWTLGWALPLAACATIIAAAAPRIPTDDLPHWLTRTKPVITHATIAATGILLMTTALMYMPMNSTGIGIIRNGGAALIGIATALTLTRIRTIRIITATGLAIGYALVVTWPTHGALITGYLIALTWWTIHLTAHTLKLAFPLKRTTLHRLITNQHHQDDRPPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5W3</accession>
    <name>F4F5W3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_22110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734175.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22110"/>
    <dbReference type="EnsemblBacteria" id="AEB45522">
        <property type="protein sequence ID" value="AEB45522"/>
        <property type="gene ID" value="VAB18032_22110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22110"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_9_11"/>
    <dbReference type="OMA" id="KISLMAC"/>
    <dbReference type="OrthoDB" id="1163259at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="501"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="595" mass="64972" checksum="1DD2BF77244A8553" modified="2011-06-28" version="1">MADETTDLLERLASLPANRREAALRLLGRDTEAGTLRPRVDPSAPVRLSSGQEQVWLTDLMTGEPGSLVDHVAFRLHGPLDLAALHTAFEDLVARHEPLRSRLIRQGEIPMLVSGSAPVDVSVTDLTGQGIAAATAAATSDLAVPFDLEQGSLARLRLYRLAPDDHVLVLASHHMVTDGVSQGVLLVDLETLYQARREGRPAALAPLRVQYGDFAQWQRGFLAGERLTALTRYWTDRLAQTSGRLLLPLDNPRSARRGGAYLDFTAPTGLADRVATAARQHATTPFVVLLTAFRLLLWRLTAQRDTLVGTPVSARPLAETENMVGYFLNMVVLRGTADADASLRDLIATEHASAMSAYAHQDLPFEQLVTQLRPPREMGSTPLVQTVFSVEGQPGMSGSYLGASCEEIVLTGGRAQYDLMVKVVRDVELTARWDFDDAIIDATRITEWAHQFWALVDAVTSDPDRRVRDIPGLGDVPPDPSQDDRSTVEVLAWAGTADRVEPQGYLQETIAAAWQSLLGVSPGAHDALFDLGGHSLTVAQLSFRLSDTFRAHVGVAELFEYQTVAAQAEYVERLLLERAAQLSPDEREQLLDGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F600</accession>
    <name>F4F600_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MaoC_dehydrat_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22295"/>
    <dbReference type="EnsemblBacteria" id="AEB45559">
        <property type="protein sequence ID" value="AEB45559"/>
        <property type="gene ID" value="VAB18032_22295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22295"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149200_0_0_11"/>
    <dbReference type="OMA" id="MEYIAGI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="134" mass="14067" checksum="54185503DA66DE08" modified="2011-06-28" version="1">MSSPDTDPRLGMSVAHRRYVSRADVRYAGDLVNGAYALAGFGDAVTELAIRTDGDEGLLAGYRAVEFHAPIRAGDVVEFTATVTRVRTRSRTVALTCSVLCRATPERGVTAAQPLQPPVVAVTAEATVVVPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F668</accession>
    <name>F4F668_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-2-oxovalerate aldolase</fullName>
            <shortName evidence="7">HOA</shortName>
            <ecNumber evidence="7">4.1.3.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-keto-pentanoic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-oxopentanoate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_28746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:36003"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17153"/>
            <dbReference type="ChEBI" id="CHEBI:73142"/>
            <dbReference type="EC" id="4.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22624"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:73143"/>
            <dbReference type="EC" id="4.1.3.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 4-hydroxy-2-oxovalerate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.39" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28746"/>
    <dbReference type="EnsemblBacteria" id="AEB46820">
        <property type="protein sequence ID" value="AEB46820"/>
        <property type="gene ID" value="VAB18032_28746"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28746"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049173_0_0_11"/>
    <dbReference type="OMA" id="WARENGM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008701">
        <property type="term" value="F:4-hydroxy-2-oxovalerate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07943">
        <property type="entry name" value="DRE_TIM_HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01656">
        <property type="entry name" value="HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017629">
        <property type="entry name" value="4OH_2_O-val_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012425">
        <property type="entry name" value="DmpG_comm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035685">
        <property type="entry name" value="DRE_TIM_HOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07836">
        <property type="entry name" value="DmpG_comm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03217">
        <property type="entry name" value="4OH_2_O_val_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="39033" checksum="F115F5FF760A93B8" modified="2011-06-28" version="1">MNELYIQDVTLRDGMHAIGHRYTVDQVRTIAAALDAAGVAAIEVAHGDGLAGSSVNYGHGAASDAEWIAAAAEVMTNAKLTTLLLPGIGTIADLKAAKALGVTSVRIATHCTEADISAQHISWARDNGMDVSGFLMMSHMNDPAGLATQAKLMESYGAHCVYVTDSGGRLLMSDVAQRVDAYRQVLEPTTEIGIHAHHNLSLGVANSVVAVEHGRIVGDGPLGSPSGRTVRVDASLAGMGAGAGNAPLEVFVAVAELHGWKHGCDVFALMDAADDIVRPLQDRPVQVDRETLSLGYAGVYSSFLRHAERASARYGVDVRSILVELGRRRMVGGQEDMIVDVALDLARDGAAEPARDGAGDPAVTQARTEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6D9</accession>
    <name>F4F6D9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhs family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09835"/>
    <dbReference type="EnsemblBacteria" id="AEB43085">
        <property type="protein sequence ID" value="AEB43085"/>
        <property type="gene ID" value="VAB18032_09835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09835"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000662_1_0_11"/>
    <dbReference type="OMA" id="NDGEYWR"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="2038" mass="221152" checksum="35C8D634F41494A2" modified="2011-06-28" version="1">MTLLQAPASARPDDPLSVEPEARPVPTVPVTNVATTAPTRAAAMRSASAKPAPIWPSAATAVAELDSSATVTSARVGGLPVRVERVGAASSQRMRAQILDIQRVRVQTLDRKATERAGIRGVLMRVGQADTAATDAARADAGSADLRMTVDYSSFATAYGADWATRLRLVTLPECALTTPEQQRCAGTPLKSRNNPVAQTVSAQLPVAAAGTLVAVAAGATGPAGDYSATPLQPSSTWSVGGNTGSFNWSYPMRVPPAPGGLEPDLAFGYSSQSVDGRHAASNNQPSWVGEGFEFWPGGYIERRYRSCAKDTGGNNTTKTYDLCWETDNATLHLDGFSGELLYNSSEQRWHLRTDDGARIVRHTGAANGDEDGEFWTLTTTDGTEYRFGSNRLPGWTSGDPVTNSAWNAPVFGNDVNEPCRKPAFADSSCERTWRWNLEHVANLNGDSMSFWYTKETNKYGRNKTASDAVSYDRGGYLKRIDYGTRVTAGRDSALDNGASARVVFTEADRCLSNCTTKNEVRWPDTPWDSECTGSTCVDKFSPTFWSSKRLSAVTTQIRSGSGFSNVERWSLTHGFPDPGDGTRAGLWLEKISHEGLVGGSTTLPDVELTGIQLANRVDTIDFAAAMNWWRIARIRNETGGTINITYSQEDCVAGSTPTAQTNTRRCYPVRWTPEGYQSAVTDWFHKYVVTTIYEIDHTGGSPPFGSPRKAYSYSYHDGAAWRYTDDDGLVDKDEKTWSVFRGYGRVGVTVGDAGEQAYTETRYFRGMHGDRAAPSGGTKSASLDGITDQDWFAGMAREVTVRNGPTGAVVSREVSDPWASGPTASRTANGDTTTARFVRVGTARSYVALDGGRGERVTRTTTSFDSLGMPIQVDDFGVEGTTGDERCTKTDYIRRDTKWLMDRVQRTRDFAVSCSASNGTLTEADVIGETRLSYDDAAYGTLPANNNDVRGLPTRTEVMAAWNAGAPSFVTKERTAYDSHGRPTSSWDAMNFLTTTTYTPALGGPTTQVVVKNPRNHETRTTLIAAWGSESSILDPNEKRTELAYDALGRLTSVWLPNRSRATESANMTFGYTVRNNAPTAVRTSKLNAEGNYVSSYELFDGLLRTRQTQAPSPAGGRLITETFYDTAGRKVREYDKYHTSGDPGTTLATAVDGAHIHTQNRIEYDGAGRPTAVIFQPYNAERWRTSIHYGGDREDVTPPTGGTATSAIIDARGNRVEQRRYHGAAPTPWTTGSWDTTTYTYNRKNQLTMLTDAAGNSWTYTFDIRGRQIQVDDPDSGTSTFTYDNADRMTSSTDGRNRKLAYRYDQLGRKIGVYENSTSGVLRAEWQYDTLAKGLLTRSIREVDGLAYQVEYLGYTDLYQESGVKYDIPTTEPGIGGAYLYEKTWNLDGSLSAVTLPNTNSDLPAETLRYGYDALGQPKTLSRVSGSTTSNYVPDTDYNALGQVENIELYTGSGARVWQGFDRELETGRITDFLTTRDAINPGVLADLEYSYDEAGNITRISDKAPDPVDDTQCFAYDHLRQLTQAWTPASGDCAAPRSVSALGGPAPYWHSWTINAIGNRTSQTVHTGSGDQVTTYTYPSAGAARPHAVTATAGAQVGSYTYDNSGNTLTRPTATAGTQTLTWDHEGRLESTTDSTGVTSYLYDADGNRLIRRDPTGTTLYLPGQEIRHNTNTNQTSCTRYYTHAGKTVASRSAAGLTWLVEDHQRTAQVAVDAATGTATTRRQTPYGTVRGSASGWPNDKGFVGGTVESAGLVFIGVRAYDPATGRFISIDPLQDHDDPLQWHGYAYANNSPITFSDPDGLKPLITDSVQGDEKHYRETGEKVVYQNGKWTSNKSSSSKTGGGTPDILRCDKQTTCTIRGQDKDTKNVVYECNSPGSCIIENRGRGSGAVYNCNVPGACKVDADCRNGQKSCSVGNAAVDGKLACRVRDSCIFYVWKHSPAPGKDAQEFHAVKDFFTMPAGYASSGAAGGAAIGCAVGLLGAGVACPVVAAKGALIGGVIGFEVGLYYYYEAYFESKKPKPIWMVPERVELARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6X9</accession>
    <name>F4F6X9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22770"/>
    <dbReference type="EnsemblBacteria" id="AEB45654">
        <property type="protein sequence ID" value="AEB45654"/>
        <property type="gene ID" value="VAB18032_22770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22770"/>
    <dbReference type="eggNOG" id="COG3502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042007_0_0_11"/>
    <dbReference type="OMA" id="ITIGHAF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024479">
        <property type="entry name" value="DUF3866"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12982">
        <property type="entry name" value="DUF3866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="346" mass="35426" checksum="881288356B5F242A" modified="2011-06-28" version="1">MELDVTLVDGTSMRALAYPELVGVPEVGDRVLLNAGALLMGLGTGGYALVVAVPDRLPPDPPQALDSRDAGHLVKARYTPLQPILLGVDEEASPHHEVLATAEDLGGLPVVTADLHSALPAILAGIRADAPQARVAYLLTDGGALPAWFSRTLSALRDELVGTISVGQAFGGDLEASTLHSGLLAARHVLHADVAVVAQGPGNLGTGTRWGFSGVAVGEAVNAVATLGGRPVGSLRISDADPRPRHRGVSHHSLTAYGRVALARAELVVPDGLDPALAAEVDAALTPLVDRHTVLRVDTAGLDAALRRSPVPLSTMGRGLDADHAYFLAAAAAGRHAARLLGSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7G8</accession>
    <name>F4F7G8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16515"/>
    <dbReference type="EnsemblBacteria" id="AEB44407">
        <property type="protein sequence ID" value="AEB44407"/>
        <property type="gene ID" value="VAB18032_16515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16515"/>
    <dbReference type="HOGENOM" id="CLU_2774821_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7745" checksum="842A6BEF9CCB44AD" modified="2011-06-28" version="1">MIHTLPDGSQLTTIETYTRELTLTDPEEIRIYSQVYDSLLADSATGKQARQLLETMRAEALDSAESQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7H2</accession>
    <name>F4F7H2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rhizopine-binding ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16535"/>
    <dbReference type="EnsemblBacteria" id="AEB44411">
        <property type="protein sequence ID" value="AEB44411"/>
        <property type="gene ID" value="VAB18032_16535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16535"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_754282_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="98"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="367" mass="39456" checksum="20F3D40DDF917E14" modified="2011-06-28" version="1">MLRTAGLLAGAGVGGSLLAACSPNGETGESSGGGGAASESFDEAIKKIVDGREIKVGFTPPVLSENFTQIEHAAWRKMHEYEQRFGCRWVWERQAPVGDFNAVQGTLGIVQSWVSRKFDAIAVCTGANFATVQNLYRDATAKGVRIYQFNQPAELYPEDQLQTVTNVGYDNRWQSGYLAGKYIAEKLNGQGNILQIWGPSGSDWTRGRKIGFNRALAENPGIKVVGEADGGYVRDKGFAAAQDLLTKNRDVNAIYGENEEMALGASQAIDTAGLKHWDDTGGILTIGADGLVSGYKQIRAGKLTATVDIGGVDQGQNLIEAIFVSAVLGQSLTQFINNPTQVVDQSNVDWHQAYTEWALAAPKKYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7N4</accession>
    <name>F4F7N4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_22855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734323.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22855"/>
    <dbReference type="EnsemblBacteria" id="AEB45671">
        <property type="protein sequence ID" value="AEB45671"/>
        <property type="gene ID" value="VAB18032_22855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22855"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_11"/>
    <dbReference type="OMA" id="IDQDLCT"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="97" mass="10355" checksum="63F39CE8F9CEB894" modified="2011-06-28" version="1">MAEVATDEVQVWVDQDLCTGDGLCVQYAPEVFEFDVDGLAYVKGPDGELQQAPGARVGVPEHLRLEVIDSARECPGECIHVVRASDGVEVAGPDAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7V3</accession>
    <name>F4F7V3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734392.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23200"/>
    <dbReference type="EnsemblBacteria" id="AEB45740">
        <property type="protein sequence ID" value="AEB45740"/>
        <property type="gene ID" value="VAB18032_23200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23200"/>
    <dbReference type="eggNOG" id="ENOG502ZYQT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1544371_0_0_11"/>
    <dbReference type="OMA" id="LWSHLGP"/>
    <dbReference type="OrthoDB" id="1785384at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="19386" checksum="E7C5D7A3CADACE79" modified="2011-06-28" version="1">MDVTSYSRRSLHPTGRILTARVARLMDGYPREVRVGQPVLVMVLAAAGVVGLLAKLVRAALSAGSGTGRRKFKELKKGPEYLVTPIRLRDDNGRLYEVELHGHLPQSALHPADLVQLTLRDQGDPDLPPKIERIVNLTTGQLLRPRTATMWSHLGPPLLLQAVLGALLLAGLAACTALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F808</accession>
    <name>F4F808_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735631.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29561"/>
    <dbReference type="EnsemblBacteria" id="AEB46983">
        <property type="protein sequence ID" value="AEB46983"/>
        <property type="gene ID" value="VAB18032_29561"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29561"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093167_0_0_11"/>
    <dbReference type="OMA" id="AYGQWES"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309153" evidence="1">
        <location>
            <begin position="31"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="20650" checksum="9B1B5EAC606733CF" modified="2011-06-28" version="1">MNSIFRKSVLGVAGLAFAGGVFAGPVAAHADAAPVRTTPVVVQAEKPDAGKLIPHGVQGAQSRIDLNGEQVANTKAIIAATKKAGMDERAAVVSIATALQESKLENLGHLGDRNDHDSQGLFQQRPSSGWGTVEQITDPEYSTTAFLKGLKQVDGWQDMPLTKAAQTVQVSAYPDHYAQWEQQAADLVAKYWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8N9</accession>
    <name>F4F8N9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23420"/>
    <dbReference type="EnsemblBacteria" id="AEB45782">
        <property type="protein sequence ID" value="AEB45782"/>
        <property type="gene ID" value="VAB18032_23420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23420"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_11"/>
    <dbReference type="OMA" id="ANEIVIC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="16711" checksum="F5A4D4854750F442" modified="2011-06-28" version="1">MMAARTLDPVRILVVDDDPGDVLMIEEALSASDVDKVIDVVGDGQEAMEFLRREGRHTDAHRPDVILLDLNMPRMDGRQVLGEVKGDADLRTIPIVVLTTSNADTDIISSYTLQANAYVTKPIDLDDFNDVVHRIDEFFGRVVVLPKQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Z2</accession>
    <name>F4F8Z2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nickel-type superoxide dismutase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30006"/>
    <dbReference type="MEROPS" id="S26.026"/>
    <dbReference type="EnsemblBacteria" id="AEB47072">
        <property type="protein sequence ID" value="AEB47072"/>
        <property type="gene ID" value="VAB18032_30006"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30006"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_11_0_11"/>
    <dbReference type="OMA" id="WWVLGDN"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="115" mass="12802" checksum="99049A7A3651BCCB" modified="2011-06-28" version="1">MEAKPVSVLRLRWPLSPVLVTGPSMSPTLRHGDAVLVRRGGREIRPGDVVIAVFRSRPDLLVVKRAVRPTDGGWWLYGDNDLVTDDSRAYGVADVLGRVVARYWPRPGRVPPRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F928</accession>
    <name>F4F928_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730730.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04650"/>
    <dbReference type="EnsemblBacteria" id="AEB42056">
        <property type="protein sequence ID" value="AEB42056"/>
        <property type="gene ID" value="VAB18032_04650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04650"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_0_11"/>
    <dbReference type="OMA" id="QWCVEDD"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="74"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="15007" checksum="EE5A53BEA2C7870B" modified="2011-06-28" version="1">MSDYRVADVMTRQVIYLPAETTLDEAARVMKEADIGDVVVTEGATLAGLLTDRDIVVRAVAANSDPTSTTIGSITTREVVMIEQNCSAGDAAALMRERGVRRVLVCDAERKLVGIVSLGDLAVQFDPQSALGQISEQAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F975</accession>
    <name>F4F975_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="3">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dcd</name>
        <name evidence="5" type="ordered locus">VAB18032_04885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730777.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04885"/>
    <dbReference type="EnsemblBacteria" id="AEB42103">
        <property type="protein sequence ID" value="AEB42103"/>
        <property type="gene ID" value="VAB18032_04885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04885"/>
    <dbReference type="eggNOG" id="COG0717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_2_1_11"/>
    <dbReference type="OMA" id="FENHRYP"/>
    <dbReference type="OrthoDB" id="1598407at2"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="21144" checksum="038B147EC1362D85" modified="2011-06-28" version="1">MLLSDRDLVSEIKAGTLALEPFEPTLVQPSSIDVRLDKLFRVFNNHLYTHIDPATRQDDLTSPVEVPDGEPFVLHPGEFVLASTLEVISLGDQLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHVTLELSNVANLPITLWPGMKIGQLCIFRLSSPAEHPYGSAVYGSRYQGQRGPTPSRAWQNWRTWPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9A1</accession>
    <name>F4F9A1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731966.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10885"/>
    <dbReference type="EnsemblBacteria" id="AEB43295">
        <property type="protein sequence ID" value="AEB43295"/>
        <property type="gene ID" value="VAB18032_10885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10885"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091587_0_0_11"/>
    <dbReference type="OMA" id="WDIRLPA"/>
    <dbReference type="OrthoDB" id="1866549at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="25976" checksum="1D7EF3AD2083E8AC" modified="2011-06-28" version="1">MDDARTSGGRQLWWWLGGVLVLVVVVLVASWTWVTVRGDGRAGHVVTGAADDLQEATFVLLDGADVIRVRTADLGEDAYRVSTPRDASVRPAVSRTDDTLMTSLRGTGKDGPAIVEVVLRESVRWHIRLDGGAKEQHLDLSNGQVNGVEFTAGANRIELTLPAPTGTQRVVLGGGASQVVVRLGTDAPVQVRAGGGAGSVTIDGTTHSGVAGGSTFTAPQWETATDRYDIDATSGVSHLSVERADAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9I9</accession>
    <name>F4F9I9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733222.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17325"/>
    <dbReference type="EnsemblBacteria" id="AEB44567">
        <property type="protein sequence ID" value="AEB44567"/>
        <property type="gene ID" value="VAB18032_17325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17325"/>
    <dbReference type="eggNOG" id="ENOG50349ZY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153832_0_0_11"/>
    <dbReference type="OMA" id="NIVEIHI"/>
    <dbReference type="OrthoDB" id="1784119at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="107" mass="11312" checksum="83917B1ECCEA8A3F" modified="2011-06-28" version="1">MASIVEIHVPLTPTPGLDPDAYAFPWIDQVEDFLVDVEDEGTIEVYDDGEQLGDVYVFFITAATEASLLTAASRVATLDGVPTGAFAIVTDEGAPDGTGRRVDLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9K7</accession>
    <name>F4F9K7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17415"/>
    <dbReference type="EnsemblBacteria" id="AEB44585">
        <property type="protein sequence ID" value="AEB44585"/>
        <property type="gene ID" value="VAB18032_17415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17415"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009095_0_0_11"/>
    <dbReference type="OMA" id="REPTWAV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119766" checksum="D2B237A96A80B78E" modified="2011-06-28" version="1">MLTATHDLLNSLDPLPYRKRMNRLAQWAQTAHDRVQVCADLRERGPYERHLAFVAARVAGDSDGVVAALRDPQPSIRGAALTSALRVGLPIGEVTDRPAVERRRVYRDLRRRPAPDIADALIGEIRAQFGDEEAAALLPACGTATVRALLPDLEHATRLERLVRWHSGPLLDRVRERLAAARPELRQRIWVEAAAAVLRCDPAQALDLLERYAPEEWLPGPLTAYGVLAAYDASRVIRLLTAPGRAAWLRRSALPPAVLRRLAVLPTDELVPLASRLHDRSRALAALLDAVAPARRGELYDRALAEVDTAAWIPSAEIMEVLPAAVRVREANRVLGLPKIREREADVRTWSAYLNWPQASAALENALRSGDADERAHSYTLLVQAARRSRDPQAVAEVVVRLGRLRNEQDPVRAAALTALARVAPLLTADTAAGLTQLSTDAVDARDASAATTTALSSLAVDVLQHHVAVPPLREWALLTIDLVSAGAHVPVLRRFDTVLRRGQETLVFQRLHDWVTAGIDRGRYGPLFALSYAFGKRAWRVPQLQDLLRRAIGPHTLPSVARTAIGLWLDDPRTRAGRVAEVVATDPSAVTIDEVWTTICTVRTDLLDQALDHRPRGRFIEAGTPWVPVRAVHPERWLPRQQARFVHLQELVIADAGQKVWFRAAAIWTAARVPGAGRELVLRHVDAPEVAIAEAALGALVWTDRPDEALRLLLRYADSDRARVALYAAGRAARHVAPSRLVPLLSEVLTGAGKITSRKEAARLLARYGPPQTMTTLLDVHRRPDAHRDVRTAIVSAARQRLHTDASWTILRAAVDGSREERRAVLGAYPGTIPHRHRPAYGALVVDACRATDREIRRAAFVQLGVWSPWLTGIADLVVHRLIDLDETITSTEVADLLEAGGEDVLRDALTRLVARDADDKHPGDPATGDRPHRRRIDLLARGAAVRSGYQPPSADRSTLVESARWLATRPGFTGTATALLVDLHRLDNLDEIADLCEGRPALAVRTAERVGARLRSLHEWPDTDALATIIVDLAERGDLAGGLFAVSLVRHGASFGWKTPWRDLLIRLRQHPDLDVRAEAYAIDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9L2</accession>
    <name>F4F9L2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_17440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733245.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17440"/>
    <dbReference type="EnsemblBacteria" id="AEB44590">
        <property type="protein sequence ID" value="AEB44590"/>
        <property type="gene ID" value="VAB18032_17440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17440"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="WNELFLS"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="32983" checksum="0A7B52DB84FAD9D1" modified="2011-06-28" version="1">MAVSVDEAVSTGPARDRTTPARRRGGRGRSVLEVALLTVLAVVMLFPVLWMIETSIKENRDVYAVPAEFFGFTVTMEHFKDVFVGPDGGRSALSVAFLNSVLVAGASTVLATLLGVPAAWAYSRFAVKAKKDQLFFILSTRFMPPVVVVIPIFLMYRQVGLIDSKLGLILIYAAYNLPFTIWMMKGFVDEVPSEYEDAAMLDGYTRLQAFRRYTLPLLVPGIAATAVFALIFSWNEFVFAIFLTSSDSVRTAPPAIAGLIGGTTTDWGLVAAASVVFALPVLVFAYLVRKHLIAGVTLGAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Q7</accession>
    <name>F4F9Q7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23675"/>
    <dbReference type="EnsemblBacteria" id="AEB45833">
        <property type="protein sequence ID" value="AEB45833"/>
        <property type="gene ID" value="VAB18032_23675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23675"/>
    <dbReference type="eggNOG" id="ENOG502ZZP3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114557_0_0_11"/>
    <dbReference type="OMA" id="ADWLFMI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="20395" checksum="BF3E0052B2D86113" modified="2011-06-28" version="1">MDTMTAMMERNTATAKTPGAPTVQERTTRKRATRYLLGGLRLALGWIFLWAFLDKLFGLGFATEAKGAWINGGSPTKGFLTFGATGPFQGFYNSIAGAAWADWLFMIGLAAIGTALMLGIGVRVAAAAGGLLLVLMWTAALLPANNPFMDDHLIYAGVLALLAVTNAGDTWGLGRNWARLPIVQRFGWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9U7</accession>
    <name>F4F9U7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45873">
        <property type="protein sequence ID" value="AEB45873"/>
        <property type="gene ID" value="VAB18032_23875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23875"/>
    <dbReference type="HOGENOM" id="CLU_3013045_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="56" mass="6029" checksum="F3913C668D20D75D" modified="2011-06-28" version="1">MVRAVVRPAVVRRCGGRRRAVEREVVQQAGGVCLDHSQPVLRWLARTSGESGGVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9U9</accession>
    <name>F4F9U9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CIS_tube domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734527.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23885"/>
    <dbReference type="EnsemblBacteria" id="AEB45875">
        <property type="protein sequence ID" value="AEB45875"/>
        <property type="gene ID" value="VAB18032_23885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23885"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101857_0_0_11"/>
    <dbReference type="OMA" id="LVWGKTW"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045361">
        <property type="entry name" value="CIS_tube_prot_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19266">
        <property type="entry name" value="CIS_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIS_tube" evidence="1">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="246" mass="26167" checksum="0BE65B7CF3D74740" modified="2011-06-28" version="1">MERVAFLIDATGERIDCLLNPESVEVTRLAGVRHRGSAGTQLTGAGRADDPLVFTGGGRTELVLDLLFDTDFAEGQVRPADVRELTRPLWLLAENSAMEHGWVRPPLVRLVWGKTWNVPGVIVAVAERFDAFTATGSPRRSWLRLKLVRVTEDADRAREGFAEELAAAQTPAVAPGTAVVAAGDGSGAVDSSGVRFDLLAHDALGSPLRWRLLAEHNRITDPLAVPAGTALAVPPLPETSSAGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Y2</accession>
    <name>F4F9Y2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="7" type="ordered locus">VAB18032_00045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00045"/>
    <dbReference type="EnsemblBacteria" id="AEB47093">
        <property type="protein sequence ID" value="AEB47093"/>
        <property type="gene ID" value="VAB18032_00045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00045"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_1_0_11"/>
    <dbReference type="OMA" id="CLVAAYD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="80"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="5">
        <location>
            <begin position="89"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="175"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="34582" checksum="2D7789C595C92D48" modified="2011-06-28" version="1">MIAVDRGRYTCVLAAAAPDAPTVTAMRARELGRKSVVVGDRVGLVGDTSGAPGALARIVRIEPRRSVLRRTAEDDASTAEGRLERVVVANADQLVIVSALADPPPRTGFIDRCLVAAYDADIEPLLCLTKADLAGPETVLDYYTELELPYVLIRPDSSLDALRSLLAGRVSVLVGHSGVGKSTLVNRLVPEAERAVGTVSAIGRGRHTSTSAVALRLPTVAGLPDDPGWIVDTPGVRSFGLAHVSAESLLHGFSDLVEATVDCPANCTHTADETECALAAWVADGRADPRRLASYHRLLASRAGETDPRGATNPRDEPEHDPRGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA19</accession>
    <name>F4FA19_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735776.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00230"/>
    <dbReference type="EnsemblBacteria" id="AEB47130">
        <property type="protein sequence ID" value="AEB47130"/>
        <property type="gene ID" value="VAB18032_00230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00230"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_0_4_11"/>
    <dbReference type="OMA" id="MFVKYSQ"/>
    <dbReference type="OrthoDB" id="902542at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="30295" checksum="84559376E984F594" modified="2011-06-28" version="1">MEQSNHREPGRERHRGAVTMRRQAIPTSTADQGLLDSRARADWRTKDSWRALRILSEFVEGFDTLADLPPAVSVFGSARSKPDSPECQLAEAVGAALARAGYAVITGGGPGVMEAANRGASEAGGRSVGLGIELPFEQGINEWVDLAIDFRYFFARKTMFVKYAQAFVVLPGGFGTLDELFEALTLVQTGKVTRFPVVLMGSDYWRGLLDWLRDTMAVEGKIGPVDLDLIRVTDDIAEAVRHIVEAEAALSPEQESVREEAVARTAADQQAAAEESER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA40</accession>
    <name>F4FA40_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00335"/>
    <dbReference type="EnsemblBacteria" id="AEB47151">
        <property type="protein sequence ID" value="AEB47151"/>
        <property type="gene ID" value="VAB18032_00335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00335"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="GSMPRID"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="37103" checksum="FFD1CC0398B6CD07" modified="2011-06-28" version="1">MVPYLRVDDLRVSFTGSDGVVRAVDGLSFAVQRGRTLAVVGESGSGKSVTALAVLGLLDARQATVTGRITLGGRQLVGRPEAEVRRLRGRDMAMIFQDPLSAMHPYYPVGRQIAEAYRVHHRRAGRAQTRRHVVELLGRVGIAQPQRCYDQYPHEFSGGMRQRAMIAMALVNDPALLIADEPTTALDVTVQARILDLLADLQVEFDTAILLVTHDFGVVAQLADDVLVMYAGRAVEQGSAEQVLRRPQHPYTWGLLSSVPSWHGDPATDLAAIAGSPPSPTDVPAGCAFHPRCRYAAETNGRCRVERPELRSAGVPGHRVACHLGDEQRARRYAQDGAGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA71</accession>
    <name>F4FA71_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_05030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730806.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05030"/>
    <dbReference type="EnsemblBacteria" id="AEB42132">
        <property type="protein sequence ID" value="AEB42132"/>
        <property type="gene ID" value="VAB18032_05030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05030"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_11"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="486" mass="50417" checksum="E18623306C674597" modified="2011-06-28" version="1">MSRIKEFNLPDLGEGLTEGEILAWLVKVGDTIELNQPIVEVETAKAAVEIPAKWAGQVQAIFHPEGTTVEVGTPIIAIDTDPGAGPVESSTEELPAPSAASLAAVDIAPAEGAVEPGLIGGPAPGGRTAVLVGYGPRTTAAKRRPRKGAAPAQATTAPVTPAAPAPVVAAPVPVQAAPVPTVNGNGHPGGPVLAKPPVRKLAKDLGVDLRTLTGSGPLGSITREDVQQAVAASSAAAEPLTVGAAATSAASFGADREQRIPVKGVRKLTAENMSRSAFTAPHVTEFLTIDMTRAMKALDRLRGRREWRDVRVSPLLLVAKAVLLAVKRHPMVNSTWAGDEIVVKEYVNLGIAAATERGLIVPNIKDAGRLTLRELADAMTDLVQTAKAGRTSPAAMSGGTLTITNVGVFGVDTGTPILPPGESAILAFGAVREQPWVHKGKVKPRMVTTLALSFDHRIIDGELGSKFLRDIGDFLTDPEAALLAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA82</accession>
    <name>F4FA82_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ordered locus">VAB18032_05085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730817.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05085"/>
    <dbReference type="EnsemblBacteria" id="AEB42143">
        <property type="protein sequence ID" value="AEB42143"/>
        <property type="gene ID" value="VAB18032_05085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05085"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_6_11"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
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        <property type="entry name" value="JDOMAIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
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    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
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    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="163"/>
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        </location>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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        <location>
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    <feature type="binding site" evidence="6">
        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="395" mass="41352" checksum="80F8C9D5885D474F" modified="2011-06-28" version="1">MSSKDWIEKDYYAVLGVAKTASADEIKKAYRKLARESHPDHNPGDPKAEERFKAVSEAYAVLGDDTKRREYDEMRSLFGSGAFRRGARQPGQPGGMPFDVSDLFGGGTPGGGGRFAGGNISDLFSSIFTGGQGGGAGGGAPGPARGRDVETEVALDFDDAVRGVTLPLTLRAPGVCDTCHGNGAKPGTQPRACPVCHGAGVTTRNQGAFSFSEPCRNCQSVGTVVDEKCPECQGTGGVTKTRTLNVRFPAGVADGQRIRLAGRGEPGTRGGPAGDLFVHVKVRPDDLFGRTGDDLTLTVPITFTEAVLGTDLRVPTLDGAVTLRVPPGTPSGRVLRARGKGVGRRDGQTGDLLVTLDVVVPAGISDEARTALETFAAHTPPAAREHLDARVRRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAD6</accession>
    <name>F4FAD6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732034.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11225"/>
    <dbReference type="EnsemblBacteria" id="AEB43363">
        <property type="protein sequence ID" value="AEB43363"/>
        <property type="gene ID" value="VAB18032_11225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11225"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_11"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="35778" checksum="D4A3014738BE6BCB" modified="2011-06-28" version="1">MARIAVVAGDGIGPEVVAEARKVIDAALPGVEATEYDLGAARYHRTGEVLPDSVLTELAGHDAILLGAVGDPTVPPGVLERGLLLKLRFSFDQYVNLRPSRLWPGVTSPLATVKPGEVDLVVVREGTEGLYAGAGGTLHRDTPAEVATEESLNTRHGVERVVRDAFARASRRERRKVTLVHKTNVLTHAGSLWARAFEAVAAEYPDVSTEYQHVDAAAMFLVTQPQRYDVVVTDNLFGDILTDIAAAVTGGIGLAASGSINPDGSYPSMFEPVHGSAPDIAGRGLADPVAAVLSAALLLDQLGHADAAARITAAVGAELAARTPGEAVRTAEVGDRIAAQVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAD7</accession>
    <name>F4FAD7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">VAB18032_11230</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732035.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11230"/>
    <dbReference type="EnsemblBacteria" id="AEB43364">
        <property type="protein sequence ID" value="AEB43364"/>
        <property type="gene ID" value="VAB18032_11230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11230"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_2_11"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB43364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="365" mass="39406" checksum="F124FF4CE42DBEEA" modified="2011-06-28" version="1">MSGGDKLDFEIRPNPAPVSAADRDALLANPGFGRVFTDHMVTIRYADGKGWYDARVEARGPIPMDPASAVLHYAQEIFEGMKAYRTADGGVTMFRPYANAARFNTSATRMAMPTLPEQTFVDSLHRLIEIDREWIPEGEDGSLYLRPFMFASEVFLGVRPANEYLYAVIASPVGAYFSGGVKPVTVWVSPDYTRAAPGGTGAAKCGGNYAASLAAQAEAAEHGCEQVVFLDAVERRYVDELGGMNVFFVYDDGSVVTPPLTGTILPGITRESVLTLASAAGHTVQERPVSFADWQADAASGRLREVFACGTAAVITPIGRVRFPDGEFTMGGGEPGTVTMALRQQLVDLQRGKAADPHNWVHRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAR4</accession>
    <name>F4FAR4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733334.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17885"/>
    <dbReference type="EnsemblBacteria" id="AEB44679">
        <property type="protein sequence ID" value="AEB44679"/>
        <property type="gene ID" value="VAB18032_17885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17885"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080668_0_0_11"/>
    <dbReference type="OMA" id="TAPDWAH"/>
    <dbReference type="OrthoDB" id="1101714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307762" evidence="1">
        <location>
            <begin position="28"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="27966" checksum="19C1C281F1AB37D6" modified="2011-06-28" version="1">MRNLLAALTALMLGVTAGSVPTDAANAAHHGSCPRHLLFCEDFEGLRPGGASTLDWGIDTRNGTLTVERARRGNQVLHIHTVDNGRAFLRVDDFAAPGNRFYGRMRLRVDAFPTAPDWAHFTLVEATGTGSSEIVRPIGGQYAPTVPGIFWGVGADGGPTGDWTNWRESAPVVEDTWQCFEWQLDPKDNRVVVWIDGVANPELTASTTRHGGNDVPFILPTVNTVKIGWQLYQGGTTPGEFDLWIDDIALSTKRIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAZ9</accession>
    <name>F4FAZ9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734614.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24320"/>
    <dbReference type="EnsemblBacteria" id="AEB45962">
        <property type="protein sequence ID" value="AEB45962"/>
        <property type="gene ID" value="VAB18032_24320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24320"/>
    <dbReference type="eggNOG" id="ENOG50331J4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949604_0_0_11"/>
    <dbReference type="OMA" id="PEVAWPG"/>
    <dbReference type="OrthoDB" id="1880768at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312856" evidence="1">
        <location>
            <begin position="29"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="30266" checksum="5FEA9E3ACDF4FAAE" modified="2011-06-28" version="1">MTTSRYGRLAVLPLLLLASAACGQQAGADGAGDSGAPEKSYSADTVVFRMDHVGGFTTPAMLATRLPAVSVYGDGRVITQGPVTLAYPGPALPNLQVGTISTAELENLIKAAREAGVGGVSDLGSPPVSDVPSTRFTVFDGTRTEQLEVYALEVGADPGAGAGQGVTADQQAARDKLRAFAESLTAETGPLGKATTDTQAYAPTAVAAVAEDYVTNSEVGDQPEVAWPGPALPGAQLSKDLGLSCVTATGDQAKQVLAAAATANAATPWSSEGRQWTVHLRPLLPDETDCGDLASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB03</accession>
    <name>F4FB03_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CopC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734618.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24340"/>
    <dbReference type="EnsemblBacteria" id="AEB45966">
        <property type="protein sequence ID" value="AEB45966"/>
        <property type="gene ID" value="VAB18032_24340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24340"/>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426953_0_0_11"/>
    <dbReference type="OrthoDB" id="1271038at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313738" description="CopC domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="6">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="641" mass="66445" checksum="894DE6F3851171D0" modified="2011-06-28" version="1">MRRCPRTTVRVTSGLLALLLATAVTLLADTTPAAAHGSLAMSTPKADATVSEPLTTVQLYFTEQVVPNAYFAVTAPGGTRVDNGWSHGQPRQLDRPVREYFLVDGTFQPREYTTGFPAVVNLAHLPAKGRYTVSYLSVASDGEAVRGTMSFRYTGAVTPAPAGWRPPTDQPDPSLVAAADQHGHDSEPSPASAAPPASAPPAAAPAPTSDGGPGAGTWTAVTIAVAAVLLGLLVWRRPVIVGRLLGRAERTPQRARGSRKGPKSVPSRSAAPAGRTRSGSATRARSGATDRRRTTVVAAARSRGEAVTAGPAATASSTALSTPPSTAPGDEPPPVDRSSNTRLALLVGGLVVALLAGFGLGRLGGGEQPAVTDARPGGLSVPAAGSAVDGHQHPPGTGAHAHTGDGGDQVAGAWVSAAGYTLQPVQRSQPPGVRVDYQFRIVDGNRQPATDFAVVHDKPLHLIVVGRDLSGYQHLHPSMSPDGVWTVPLELPRAGDYRLYADFSVTTADGRQLPLVLGVDHHVPGVYTPAQLPAPEPKATAGPYAVSMEGTPTIGLSAPIVLRVAGASGPAQLEPYLGAYGHLVVVREGDLGYVHVHPEPELVDGAVTFWLTVPSAGRYRAFFDFQVGGKVYTADYTLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBA3</accession>
    <name>F4FBA3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05365"/>
    <dbReference type="EnsemblBacteria" id="AEB42199">
        <property type="protein sequence ID" value="AEB42199"/>
        <property type="gene ID" value="VAB18032_05365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05365"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123202_1_0_11"/>
    <dbReference type="OMA" id="ETDAATW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP_3" evidence="1">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="12826" checksum="76A6F989C943D6AE" modified="2011-06-28" version="1">MSSPYDKSAAVAAAMAALDEGRAPERSVLRVAVRALLTTLADRTPGRSVEVRVPPYGAVQCVPGPRHTRGTPPNTVEMDPQTWLALATGRLEWTQAVTEGCVRASGTRADLSPYLPLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBE8</accession>
    <name>F4FBE8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730917.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05590"/>
    <dbReference type="EnsemblBacteria" id="AEB42244">
        <property type="protein sequence ID" value="AEB42244"/>
        <property type="gene ID" value="VAB18032_05590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05590"/>
    <dbReference type="eggNOG" id="ENOG503167U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098561_1_1_11"/>
    <dbReference type="OMA" id="EIGICFW"/>
    <dbReference type="OrthoDB" id="1759770at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025495">
        <property type="entry name" value="DUF4386"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14329">
        <property type="entry name" value="DUF4386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="24003" checksum="3561A4C7D9A90143" modified="2011-06-28" version="1">MPPLIRTARTTGLLYLGLAIAGALGFLTIRPRIFAAGDPEATLAHLVQNESLARVAIALELLVVLTQTGTAVWFYRLFRTVDGVAAGCIAAFGMVNAIAILGSAALLATATEVAAQPFGDAADSVQLLYLVSGNLWTVGGLFFGLWLVPMGLCVLRSGWLPRALGWVLVAGGVGYLLHTFVAYLAPGTGMLADLLVVPATVGEFWILGYLIILGVRRSALPTPAEAPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBE9</accession>
    <name>F4FBE9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05595"/>
    <dbReference type="EnsemblBacteria" id="AEB42245">
        <property type="protein sequence ID" value="AEB42245"/>
        <property type="gene ID" value="VAB18032_05595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05595"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069543_3_1_11"/>
    <dbReference type="OMA" id="HPWAPAL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="22006" checksum="952BA5088E37EC37" modified="2011-06-28" version="1">MDAEGLAALTMRRLAAEVGVEAMSLYHHLPGKEGLLDGLAEAVVAEIQAAVDTTLDDGHWRARLRQRFLAARTVMLRHPWAPALLGSRPTIPVGLYGYYDGIIATLRDGGFSYRIAHRALHAFGSLALGFAQEVFRPASAGGETDVEAAEEELAAMAAHLPHLTAMVAAEAHAADDPTLGWCDSQVEFEFTLDLLFDGLEKARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBL6</accession>
    <name>F4FBL6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732147.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11820"/>
    <dbReference type="EnsemblBacteria" id="AEB43478">
        <property type="protein sequence ID" value="AEB43478"/>
        <property type="gene ID" value="VAB18032_11820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11820"/>
    <dbReference type="eggNOG" id="ENOG503367X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067785_0_0_11"/>
    <dbReference type="OMA" id="HIGWREQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="37642" checksum="50E71263456BE90A" modified="2011-06-28" version="1">MSRLEERYRLLLRLLPAAYRQEWEDDMVAAFLESMDTGDPETTAYLADYGRPSLSEAASIVALAVRLRLRADTSPRSRVWGHAVRLATLMLLLTHAVMVTGSIAVTLWYAGKLAWLPAPAPELTFSTPASIWSTTWHLAGYAWLPAYLALVLGYRRVAQAVALIAIVPPAITVAMAQAVGDVPLTVSPWAMRLVDVALLLAMAAFPHGAAPVSRRPWLLALPTGIFLVALPLFSLQAVEPALRLLDWPGLLCTAVAVAMAVHLTARATGRSTRTLPWSLAFTLLAATALVLRAATLPDFLDQAERTTLTTIAFVQVIAVLAVGVPLAVSALRALRNVPSAPAATPKPTTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBM3</accession>
    <name>F4FBM3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732154.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11855"/>
    <dbReference type="EnsemblBacteria" id="AEB43485">
        <property type="protein sequence ID" value="AEB43485"/>
        <property type="gene ID" value="VAB18032_11855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11855"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127592_1_0_11"/>
    <dbReference type="OMA" id="GWRFEDY"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="122" mass="13189" checksum="FAB338E12A623B80" modified="2011-06-28" version="1">MSQPTTHRHHCIDYIEFTVTDLAEAKRFYAEAFGWQFTDYGTAYAGIRGGSGAEVGGLRQEQQARTGGGPLVLLYSADLEQSVEAVEKAGGTVVAGPYEFPGGRRFHFTDPSGNELGVWAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBX3</accession>
    <name>F4FBX3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18355"/>
    <dbReference type="EnsemblBacteria" id="AEB44773">
        <property type="protein sequence ID" value="AEB44773"/>
        <property type="gene ID" value="VAB18032_18355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18355"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_2_2_11"/>
    <dbReference type="OMA" id="FEYYVLA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="154" mass="16906" checksum="B23F70C656FAF042" modified="2011-06-28" version="1">MTDHERDAWLALAKLMFNLPSALDAQLLRDSHLTLFDYFVLSGLSMTPGRTMRLSDLASFVSSSLSRLSNVVKRLEQRGLLRRAPDPESPRYTVATLTDAGWDLVVAAAPGHVAAVRHYVIDGLTPSQIDVLREVACHVTRQIAAAPESASQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBY2</accession>
    <name>F4FBY2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC/XylS family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18400"/>
    <dbReference type="EnsemblBacteria" id="AEB44782">
        <property type="protein sequence ID" value="AEB44782"/>
        <property type="gene ID" value="VAB18032_18400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18400"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082704_0_0_11"/>
    <dbReference type="OMA" id="ITHEVGY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="222" mass="24794" checksum="7E27994A414F3364" modified="2011-06-28" version="1">MDGMARTAMFSKFHFTRIFQRTTGISPGRFLMVMRLHRAKQLLLSTSMSITEITHEVGYASVGTFSSRFSSSVGVSPSTYRRLRGVTPQVPVDNRAVAQPPIPAIQGMVHAPESEESEDRLTFIGLFRDPVPLGRPVRCTVLEKPGPYRLDSPPPGQWYVLACSRLRGRQDYWQANWSDDDALIGVHGPMTISRRPGAMEADLHLRRMTPLDPPILLALPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCE8</accession>
    <name>F4FCE8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 2C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730948.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05745"/>
    <dbReference type="EnsemblBacteria" id="AEB42275">
        <property type="protein sequence ID" value="AEB42275"/>
        <property type="gene ID" value="VAB18032_05745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05745"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_0_2_11"/>
    <dbReference type="OMA" id="CVLARYH"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="239" mass="24948" checksum="36E38CEE5308D272" modified="2011-06-28" version="1">MTLILRSAILNDIGLVRTNNEDSALAGERLVAVADGMGGLPAGEVASEIVIRILDELIPPTAPDAAADALRAVVSTANQRIHAAIVADPARDGMGTTLTAALLAGNTLVLAQVGDSRCYLLRDGRLTQLTRDDTFVQALVDQGALTRDQARHHPQRSLVTRAVQGADAPPTMGMLTIAAGDRLLLCSDGLSDYVTDDAIAATLGLHADRHQCGEQLVKLAHQAGAPDNVTVVISDVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCV2</accession>
    <name>F4FCV2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732265.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12410"/>
    <dbReference type="EnsemblBacteria" id="AEB43596">
        <property type="protein sequence ID" value="AEB43596"/>
        <property type="gene ID" value="VAB18032_12410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12410"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_3_11"/>
    <dbReference type="OMA" id="NATAHPR"/>
    <dbReference type="OrthoDB" id="1746185at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="24658" checksum="FBB5BB92E2CEE1C8" modified="2011-06-28" version="1">MRELARAGRQRGRWSTYRNVVPDWFRQYLDLEADATEIRWYQPEIVPGVLQVESYIRALNATAHPRLTDEDVDRQVEVRLERQAILRNPEGPQVSFVLSESALRRTIGDHEVMRDQLLHLAEVSGRPNVELQIFPFDAQTYATASYSFIILRFGEDATTDVVYVETFTDADYLDRPDAVRAYTRLWDRLRAAALGPVESRKLIQRMADDMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCX7</accession>
    <name>F4FCX7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733464.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44809">
        <property type="protein sequence ID" value="AEB44809"/>
        <property type="gene ID" value="VAB18032_18535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18535"/>
    <dbReference type="HOGENOM" id="CLU_789726_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="36969" checksum="57809125121EABA7" modified="2011-06-28" version="1">MSDPAYEFSDLSDPRGRRGSAPQGAFADPPRPRFSRSATTPLAPMQRQPLEPIHETEQMYEGEQLYDSPPSPTGSMGSTGSSSSISLAEVGAEVVAVADNGSMLARFGKQTFYWMQTVGAVTSLVGAGIRGASSATESAGDYVQGVGGLMTAIGTAYTSYETARDAMRQGQVDPETGLAAQQIHRLKTATSKPAVEVAADLVSFTGGTVTAVASLVQGRPDIAFAGTLVNATAAAIKGFNERRGEPDVGGAEFLIANRQKIMALENWTRLPAKVQRPLTEYFSKVDQKADRKRAAAMQSHAGAGRPTTGRSSSVSLPSGSGYRYQQDPQAGLTELTRRNSQGGQGRRGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD48</accession>
    <name>F4FD48_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734730.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24900"/>
    <dbReference type="EnsemblBacteria" id="AEB46078">
        <property type="protein sequence ID" value="AEB46078"/>
        <property type="gene ID" value="VAB18032_24900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24900"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044153_0_0_11"/>
    <dbReference type="OMA" id="DEFIYYH"/>
    <dbReference type="OrthoDB" id="1742732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="31"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="344" mass="37983" checksum="1E48B14B5046905A" modified="2011-06-28" version="1">MSLTAQAPVAHLDVRHEPGKPTILVTPSFDDLDDAVGWLTAQRAAIRAELLHCGSLMIRGLPVGDTTDFARVRDVLMPQQTGYREKATPRTDFGQGVFSSTDLPAAQPIRLHNENSYTLDFPGTLLFGCVVAPEEGGATTVGDMREALRLMPADLRERFAAHGWLLVRNYSELAGLPWQTSFASDDPADVQSYCDENVIGYEWLDEEELRTRQRRSAIVTHPVTGEQSWFNHYAFWNRWTLDADVRDVLLDTYGDDGLPFDTYVGDGSALTREEVESIAAVYEQVTVRETWQVGDLLMVDNILNAHGREAFSGARKILVAMGDPVALADCAPQTPPSTTVSDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD88</accession>
    <name>F4FD88_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma-24 subunit, ecf subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_25100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734770.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25100"/>
    <dbReference type="EnsemblBacteria" id="AEB46118">
        <property type="protein sequence ID" value="AEB46118"/>
        <property type="gene ID" value="VAB18032_25100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25100"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OMA" id="NQRISTW"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="19033" checksum="D2D4EE12E65DB493" modified="2011-06-28" version="1">MARGDAEFVEFVQAASGRLAHAAYLMTGDHHQAEDAAQTALVRTYASWSRVRRDDPYAYTRRVMINYIVDNWRRPIREYPVDEVPHQRRGDVADEVTARRWLQLALGALTARQRAIVVLRYLFDLPEQQVARELDVSLGTVKSTTSRALEKLRQTLVELPTAPGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDT6</accession>
    <name>F4FDT6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732286.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12515"/>
    <dbReference type="EnsemblBacteria" id="AEB43617">
        <property type="protein sequence ID" value="AEB43617"/>
        <property type="gene ID" value="VAB18032_12515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12515"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_11"/>
    <dbReference type="OMA" id="GLAFESM"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="21184" checksum="40EF001417272B75" modified="2011-06-28" version="1">MGHADLIDHEELRTPRLSLRRPTPADIDTIHRLHRDPRAYAHNPADALDTRAEAEERYLRWNEHWERHGFGYWTVHLHLRDHQPLGFCGIKLMTLHGRTVSNLFYRLDPPVWGNGFATEAATAVVDWAAGHLTAHPVIARVRPDNTASSTVAVRAGLRRAPQLDTEGEDGLDWIFTANWPEDPDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDU5</accession>
    <name>F4FDU5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type iii restriction protein res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732295.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12560"/>
    <dbReference type="EnsemblBacteria" id="AEB43626">
        <property type="protein sequence ID" value="AEB43626"/>
        <property type="gene ID" value="VAB18032_12560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12560"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020861_2_0_11"/>
    <dbReference type="OMA" id="HLKKQWA"/>
    <dbReference type="OrthoDB" id="458022at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="576" mass="62470" checksum="31A1669027BE0ECC" modified="2011-06-28" version="1">MAARTPALESFPPLRAWQRKALVEYLRRRSEDFTAVATPGAGKTTFALRIAAELLADGTVEAVTVVAPTEHLKTQWAESAARVGIQLDAAFRNADLHSSADFHGAVVTYAQVGMAPHVHRRRTMTRRTLVILDEIHHAGDSRTWGDGVKAAFEPAVRRLMLTGTPFRSDDNPIPFVSYERGEDGLLRSRADSVYGYSDALREGVVRPVLFLAYSGETRWRTNAGEELAARLGEPMTQDLVAQAWRTALDPAGDWMPQVLRAADARLSVLREAGMPDAGGLVIATDQQAARSYAKLIEQVTGEKAAVVLSDDVGASARIATFAASEQRWLVAVRMVSEGVDIPRLAVGVYATSASTPLYFAQAIGRFVRARRPGETASVFLPSVPHLLGLASEMETERDHVLGKPKDREGFDDDLLERAQRDEQASGELEKRFAALSATAELDQVIFDGASFGTAAQAGTPEEEEYLGLPGLLTADQVAALLSKRQAEQLAAQRRRAAERQSEASAPVAAPPAPMSAAQRRVALRRQLNALVAARHHRTGQPHGKIHAELRRLCGGPPSAQATIEQLEERIATVQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEK9</accession>
    <name>F4FEK9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736085.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01835"/>
    <dbReference type="EnsemblBacteria" id="AEB47451">
        <property type="protein sequence ID" value="AEB47451"/>
        <property type="gene ID" value="VAB18032_01835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01835"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045657_0_0_11"/>
    <dbReference type="OMA" id="RPGMNAV"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307852" evidence="3">
        <location>
            <begin position="33"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="69"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="462" mass="46514" checksum="833A5E84BD59EA72" modified="2011-06-28" version="1">MRRLDPPRLLAAPRPRLLTALLAVAVLTLTSAASCGSDEPPIALASAVLAPVTEEIDAPATVVARAAATLTAPADGTLRSLRVEPGQQVKRGQVLAVVDSPSARERLRQARAALDAAKRAGGGGGGNLTGSLRGTDRAAAQAHAAARAAAGKISDPKLRKALLAQVESAQRQYDAAARAADRAVREVQRGVRSLNSAVGALATAQRLQAQQAYDLAKATVDALTLRAPIAGVVQPGGVSSGAGSTGALAGLLDAAGGGLPSGIDPGALGAPAAGPPAGVDTAIPVGGRVTAGTPVLTVVDTRELGLLAEVDETDVLLVQVGLTGTVELDAVTGATYPATVRSIDVLPSTSARGGVSYRVRLSLGAGRYGEAEPAPAPRPGMNAVLRLRVREASDAVTVPASAIFSADGRDTVWVVRDGRVGRASVTVGVQGQDLVQIVDGVQPGDRIVVRGTDQVRDGQEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEM4</accession>
    <name>F4FEM4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily mfs_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_01910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01910"/>
    <dbReference type="EnsemblBacteria" id="AEB47466">
        <property type="protein sequence ID" value="AEB47466"/>
        <property type="gene ID" value="VAB18032_01910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01910"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_60_4_11"/>
    <dbReference type="OMA" id="MYVFDEL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="24"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="433" mass="44906" checksum="A35F46F6BC9ADFB2" modified="2011-06-28" version="1">MRERQVATAVRGWFADTAGGLPATFWYLWVGLLINRAGAFAMLFLSLYLTAARGASESLAGVVVGAYGAGGAAGVLLGGVLADRWGRRSTLVAAHLVTAALMVALALSQHLGVIAALALLVGVTHSMPSPAFVAAIVDVVPEERRSRAFNLQFWAFNLGMAVASLLAGLLAEASYVALFLVDAAATLATAVLIAWKVPETLPSLRAYGPTKPAAAGRRPGLHTALTDRHFMIFVGLTFVLAVLTMQASTIMPLTMRADGLGPSAYGTVVALGGVLIVLGQLFVPRLIDRRRKGTVLAVSTALLAVGFGALAVADDLVFYLGACVVWTVGSMLAAPPNAQINADLAPPALRARYQSVFYLAFPAASFVAPTLGGFSLQSWGDGHWLVMGALGLLAAGGHLLAGPPRERRVAALRRTSATPAADEAARAPLPAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEQ3</accession>
    <name>F4FEQ3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731120.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06615"/>
    <dbReference type="EnsemblBacteria" id="AEB42447">
        <property type="protein sequence ID" value="AEB42447"/>
        <property type="gene ID" value="VAB18032_06615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06615"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_1_1_11"/>
    <dbReference type="OMA" id="MGEHRRY"/>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="19878" checksum="FA8E65DA7A04FE1F" modified="2011-06-28" version="1">MRLFIAVYPPAEAIGHLFSEVAGLRLSAAAAAGTNVRLVDPGKAHLTLAFLGEVDPTRLTAVQQALRLAVATAGGGPPPMLRLGGGGRFGPGRSTVLWVDVHGDVDRLAALVGEVRGGLAAIGVPSDDKPFRPHLTIARPGDRMPPHDVEADLAVLDNYLGPPWPATELVLVHTHPGPPPTHHPLTTYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEX3</accession>
    <name>F4FEX3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732353.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12855"/>
    <dbReference type="EnsemblBacteria" id="AEB43685">
        <property type="protein sequence ID" value="AEB43685"/>
        <property type="gene ID" value="VAB18032_12855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12855"/>
    <dbReference type="eggNOG" id="ENOG503448R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848966_0_0_11"/>
    <dbReference type="OMA" id="HITHAGI"/>
    <dbReference type="OrthoDB" id="1401225at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="35401" checksum="599C4D97DCEC953A" modified="2011-06-28" version="1">MSPSERRRPAQPPLRLLQVVYGARRRAGLVADRLARRTNQLRRDPVADLPEVDCDFFAVLDGRTLHLHALLPSAAVPAPSRATLIFLQGAQVVECPATVEAEGDAFGVRVQAAFGTGNDDISLAKGVWSLALAVSGEAGEQQFALRAGESPEHDGPTVPAPPHPISGWRYEPGLGPHGLAQLTVAGAKARAEVIQLATGRTEARIQARLLGVRSLEDPVVVFTPRAGGADLVIPIDPVDGRFEFVVPLAELASGPPGTEVIWEAWVRTSPTRMIRLGRFLHDLRDPRTVLRVSRSTVVVGDRHFVGYRPYYTKAGNLAVACLHFTGAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEZ9</accession>
    <name>F4FEZ9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12985"/>
    <dbReference type="EnsemblBacteria" id="AEB43711">
        <property type="protein sequence ID" value="AEB43711"/>
        <property type="gene ID" value="VAB18032_12985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12985"/>
    <dbReference type="eggNOG" id="ENOG50334JF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166664_1_0_11"/>
    <dbReference type="OMA" id="EPPRYCA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="67" mass="7314" checksum="5C655C9A3D888CA8" modified="2011-06-28" version="1">MTPMDEAVGMWCDRCGEAATTGTHPGCAAARTLEPPRYCAHCRRRMKVQVLPVGWSAVCVEHGELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF19</accession>
    <name>F4FF19_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732399.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13085"/>
    <dbReference type="EnsemblBacteria" id="AEB43731">
        <property type="protein sequence ID" value="AEB43731"/>
        <property type="gene ID" value="VAB18032_13085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13085"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061176_0_0_11"/>
    <dbReference type="OMA" id="FNRGTNK"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="36093" checksum="E3F50DB7022F2927" modified="2011-06-28" version="1">MRLLMLGGTGFVGGATVREALTRGWSVTVFNRGRHGAAPAGVRRLVGDRLAPDGLAALADGEWDLVVDTWDGAPRAARTVARLLDGRIGHYVYVSSGSVYAPPVPVGVTEQSPVVDADPDATEGDYPQVKAGAERALREVFGERVLLARAGLILGPGEDIGRLPWWLSRIARGGDVLAPGPADLPVQYIDVRDLAAFLLDAGSARRGGPVNVVGRPGSATFGELLDACRTVTGADARLRWVEPERILAAGVVPWNDLPIWIPPGHKWRWMQEKDVTRAYADGLRCRPLADTVADTWSWLRRVGELPSRAGRPARPPVGLDPQREAALLATPTADRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF34</accession>
    <name>F4FF34_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732414.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13160"/>
    <dbReference type="EnsemblBacteria" id="AEB43746">
        <property type="protein sequence ID" value="AEB43746"/>
        <property type="gene ID" value="VAB18032_13160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13160"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092367_0_0_11"/>
    <dbReference type="OMA" id="RRMEADW"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="27922" checksum="7F08153FD679406F" modified="2011-06-28" version="1">MLRVLTWNVRNGGRDSGGPDRRDALLRVIAQTRPDVLALQELRGLDVTAFAARLGLRPYVAGSWFGQPVAVLVRPTWPVLAAAPVRRPFHHGAQRVTIGTDAGPLTVLSTHFYPYSGRRRLIEAGWAAAALRRARGGLALLAGDLNTLDPYAEHAEQIARLPETYRRRHLRRDGRTPDTRAVARLLAAGLVDLGAAAGPTVPTGYAGAEFSDMRLDYLLATPALATHLLTVDVLRTPQTHQASDHHPLLTTLSLTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFJ4</accession>
    <name>F4FFJ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-6-phosphate dehydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734947.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25990"/>
    <dbReference type="EnsemblBacteria" id="AEB46296">
        <property type="protein sequence ID" value="AEB46296"/>
        <property type="gene ID" value="VAB18032_25990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25990"/>
    <dbReference type="eggNOG" id="COG3429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046988_1_0_11"/>
    <dbReference type="OMA" id="GDTDLSW"/>
    <dbReference type="OrthoDB" id="1406083at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="37023" checksum="12B30459FC7116A6" modified="2011-06-28" version="1">MIGLWDTTGNEVVKALAAERRSAGGVASGMALTLIVVVDEKRVRDAEAAATIAAAAHPCRLLVVVRSDLERDRSRLDAEIVVGGRLGPCEAVVMRMYGRLALHAESVVMPLLVPDVPVVTWWHGEPPMEIATDFLGVVADRRITDSAQAADPIEALRQRARDYAPGDTDLAWTRITPWRAVVAGAFDTTEAQLTDAAVVAPPSDPTAALMRGWLRSRLGIKPRWERTKEFPRMREVQLRCANSDELTLTRDDNVAIFRRTGQEDRILPLVRRPLGDELAEELRRLGPDQVYAEALGAFAGLTTLDRRPGQRVHVWKDPATAERAEAGVTAHTSTSAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFK7</accession>
    <name>F4FFK7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_02000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736118.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02000"/>
    <dbReference type="EnsemblBacteria" id="AEB47484">
        <property type="protein sequence ID" value="AEB47484"/>
        <property type="gene ID" value="VAB18032_02000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02000"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_4_1_11"/>
    <dbReference type="OMA" id="LYFPMLI"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="25641" checksum="159F7B9EE1080E2A" modified="2011-06-28" version="1">MHAFSQILKTEARLYLRDTSTMVLTIALPTLILVVLGLIPTLRKPTPDLGGQSFVTYFTPSLLVVTLAMVGVNVLPTVLATYRERGILRRLATTPASPLALLLAQLVLALIGILASAVLLAVVARLAFGVPLPQHPLGFAAALILGTAALLALGLLVAAVAPTARSAQALTVPVFMAVMFFGGVYLPRFLLPDFLAEIGAYTPPGVQALLDAWTGTAPHPLHLAIMAVVAVTAGALATKLFRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFM4</accession>
    <name>F4FFM4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02085"/>
    <dbReference type="EnsemblBacteria" id="AEB47501">
        <property type="protein sequence ID" value="AEB47501"/>
        <property type="gene ID" value="VAB18032_02085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02085"/>
    <dbReference type="eggNOG" id="ENOG5030HNV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3384342_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="33" mass="3346" checksum="BBD57DCE6F52BAA0" modified="2011-06-28" version="1">MVTEIGFVSLLVAGLGALAGGLIYLAVRISRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFP3</accession>
    <name>F4FFP3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736154.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02180"/>
    <dbReference type="EnsemblBacteria" id="AEB47520">
        <property type="protein sequence ID" value="AEB47520"/>
        <property type="gene ID" value="VAB18032_02180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02180"/>
    <dbReference type="eggNOG" id="COG1392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086031_0_1_11"/>
    <dbReference type="OMA" id="LFNGKYD"/>
    <dbReference type="OrthoDB" id="1837604at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="23931" checksum="3E11E14C4CB3D4CE" modified="2011-06-28" version="1">MKFSFRPNEGAFYELFTRAAQNLVRGTELLNELALPDVEVQSVSERLTEVEHDSDKITHELYKKINSTFVTPFDREDIYRLGSLLDDVMDHLEAVGNLLYLYGLTKLPSLPREMHELVHVLDQQAKLTAEAMPRLKSMKDLEDYWIEINRLENDGDQAYRMLLVRLFSGEYDALTVLKMKEVADELEAACDSFEHVANTVETIAVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFR7</accession>
    <name>F4FFR7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736177.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02300"/>
    <dbReference type="EnsemblBacteria" id="AEB47544">
        <property type="protein sequence ID" value="AEB47544"/>
        <property type="gene ID" value="VAB18032_02300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02300"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_11"/>
    <dbReference type="OMA" id="DDVNRFC"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="86"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="428" mass="44835" checksum="9ED5BDE41EC3965E" modified="2011-06-28" version="1">MTSTLAPSGINTATSPARALVCRACSARYPLAAQHACYECFGPLEVDYDPAALAAVTREQIEAGPRNIWRYAALLPAGQDPTTRVTLEPGFTPLVAADRLAAELGITAPLWVKDDSANPTHSFKDRVVSVALTAARALGFSRFACASTGNLANSVAAHAARVGVPSVVFIPSDLEQGKVVTTAVYGGELVAIDGSYDDVNRLCGELVETDEFEDTAFVNVNVRPYYAEGSKTLGYEVAEQLGWRIPAQVVVPMASGELLTKIDKAFTELVEIGLVEAPAGGWKVFGAQSAGCNPIATALHADSDVITPVKPTGIAKSLNIGDPAAGLYALEAVRRTGGWMEYADDDEIRAGVRLLARTTGVFAETAGGVTVAVLRKLVESGRLDPTAETVVFNTGEGLKTLDAVAGEVGPTHRIKPSLRAARDAGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFX3</accession>
    <name>F4FFX3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase, FabA/FabZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731226.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07145"/>
    <dbReference type="EnsemblBacteria" id="AEB42553">
        <property type="protein sequence ID" value="AEB42553"/>
        <property type="gene ID" value="VAB18032_07145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07145"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_4_0_11"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="144" mass="14856" checksum="66A1A2E9E662913E" modified="2011-06-28" version="1">MTAATATPVWRPAAPVGFAAPLPAVDLIRVAAVDDGWTVSARVVVDSESPNLAGHFPGQPIYPGVFVVETLCQAMAQAVPGAPRLRTVTSVRFLAALLGGDEMTLDLDVRPTPPAGWAVRGTARRLDGTVTAQLRAVFDAGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG43</accession>
    <name>F4FG43_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732454.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13375"/>
    <dbReference type="EnsemblBacteria" id="AEB43787">
        <property type="protein sequence ID" value="AEB43787"/>
        <property type="gene ID" value="VAB18032_13375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13375"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="OMA" id="MPWEVAG"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="31100" checksum="BD7DF052C0029DD5" modified="2011-06-28" version="1">MQAVVFRQVGGPEVLEWAEVETPEAGPGQVRVSVRAAGVQPIDCAVRAGRTPDWARAPLPAVPGNEFTGVVDQVGDGVDGVAVGDEVLGFGFMNAAAEFIVVPADQVTAKPAAMPWEVAGGFSGAAQTAHIALEQIRPAYGETLLVHGAAGAVGAVAVQLALRAGARVVGTAGTANQDYLRTLGAMPVVYGPDLVDRLRGLLPGGADLVLDGAGGEALTASLALCPDRSRILTLTEHARAADLGIRTTPNLRSAARLAALAALYATGDLRFLVRRTYPMAKAADAHREVETGHGRGKVVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGD9</accession>
    <name>F4FGD9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733732.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19875"/>
    <dbReference type="EnsemblBacteria" id="AEB45077">
        <property type="protein sequence ID" value="AEB45077"/>
        <property type="gene ID" value="VAB18032_19875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19875"/>
    <dbReference type="HOGENOM" id="CLU_1495594_0_0_11"/>
    <dbReference type="OMA" id="EAPRELC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="180" mass="19677" checksum="FAE4D2A185661413" modified="2011-06-28" version="1">MTEANRELPAPPTSAAPPGMVLVAVPVAHLPHVARLLADLDARQRSAPLPRHRSTPRPDAPTQGWTVDELRRLSRGTSATHRTVAALLDALSAEPGRGFTVEELSQRTGRPRQKIIGAMAGLTRLLKAHHDYAGRGLPFDRSPGRPEAPRELCYSVDRDRAADWREARLPRLTDEGSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGN4</accession>
    <name>F4FGN4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735020.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26355"/>
    <dbReference type="EnsemblBacteria" id="AEB46369">
        <property type="protein sequence ID" value="AEB46369"/>
        <property type="gene ID" value="VAB18032_26355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26355"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_11"/>
    <dbReference type="OMA" id="CSSKWAF"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="277" mass="29709" checksum="B0A2A2C6BE57F5CE" modified="2011-06-28" version="1">MDTDAKGRIWFITGASRGLGRAFTEEALAAGDRVIGVARDVSPLAELIDRSDGRLVAYPLDVSDRAAVMAGVRRAVAVFGRLDVVVNNAGGALLGMIEEVSEEQARRHLDTNLFGVLWVAQAVAPYLREQRSGHLLMISSMGSAGGFASTGLYGAGKAAVGAISDALAMELADFGVHVTLVGPGGYETGLFTKGLTLADPNPAYAELRARLERLWGESRDFDPADAARVLREIVDLASPPRRIVLGGVAFDMVAELERTRWAEYARWEALSRRADRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH05</accession>
    <name>F4FH05_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amylo-alpha-16-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731292.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07485"/>
    <dbReference type="EnsemblBacteria" id="AEB42619">
        <property type="protein sequence ID" value="AEB42619"/>
        <property type="gene ID" value="VAB18032_07485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07485"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019216_1_0_11"/>
    <dbReference type="OMA" id="AAYNPMS"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="8"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="337"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="689" mass="77492" checksum="009378BB0E9971E7" modified="2011-06-28" version="1">MKPLVNILDGNTFLVSDRQGDVDPSPAFPTGLFSYDTRFLSTWQLTIDGGRLTALSVDDLQYYESRFFLVPGEPTHYVDTDISVIRHRTIGGSFDEDLAVLNEGNEPAELVVRVEMGADFADLFEIKNPTRKVAPVTVTVRDGLLCFTYRRGSFERQTVVSSSVAGDVDEHGMTFRIQVPAHAEWRTRFHVATNILGAQGRDFRDSLRLHRPRSAAQIAEALTRWLDATPRLVSDSETLTSTYRRSLTDLAALRYTSVSTATHLVAAGLPWFMTLFGRDSMFTCLQSLPFLPRLTPPTITALALAQGSRFDDFRDEEPGKILHELRYGESAGFEEQPHSPYFGSADSTMLFVILLDEYHRWTGDDTLAKRFEMEARAALDWIDTYGDLLGTGYVWYQTRNPETGLQNQCWKDSWDSISYADGRLPGFPRATCELQGYAYDAKMRGARLARLLWDDPAYAQRLEHEAAELKDRFNRDFWVGDGRYYALALDAEGGQVDALSSNIGHLLWSGIVDQQRAADIVGHLLGPRLFSGWGIRTLATGNGRYNHLGYHVGTVWPFDNSIIAWGLWRYGFREEAALVCQAMLDAARYFQGRLPEAFAGYDRKRTKYPVQYPTACSPQAWSAGTPLLLIRVLLGLQPHGDHLVVDPALPDSINRIELLDIPGRWGVVDALGRRRPDTNHNERDSASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH16</accession>
    <name>F4FH16_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42630">
        <property type="protein sequence ID" value="AEB42630"/>
        <property type="gene ID" value="VAB18032_07550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07550"/>
    <dbReference type="HOGENOM" id="CLU_1453841_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="18755" checksum="EEB0DD5E02E5F4CC" modified="2011-06-28" version="1">MGFHVPQGHLTEAIGLTAAIPVPEGCALQPGRLLHPPLSIPEQEGSHPHDLGLPVPTHRRSELAEHAAAAHTAAAEPGGPALLLVAADAAYLACNGLPAAPSGPEQAATCPVQACASSTLATIRQGHTGNDLLIALPLRRPDARLVEELRAAASHGHSTLVITVVDGTAGLSTATVPTPPGPPPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH64</accession>
    <name>F4FH64_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_13650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732509.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13650"/>
    <dbReference type="EnsemblBacteria" id="AEB43842">
        <property type="protein sequence ID" value="AEB43842"/>
        <property type="gene ID" value="VAB18032_13650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13650"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OMA" id="VEFGRYP"/>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="277" mass="29370" checksum="D3CEAD0BCDA31C5F" modified="2011-06-28" version="1">MSSGLASNDADQRLRGVDLCLGYHGTAVVHGASIGLRAGKVTALVGPNGSGKSTLLRALARLHPIDTGTVLCADGIAAASLPAKEFARRVTLLAQSRPVPNGVTVRDVVGYGRHPYRGRWRTDDPEGPTAIARAMAVTGVAAMADRPVDELSGGELQRVWLATCLAQDTAVLLLDEPTTFLDLRYQVEILDLMRDLADEHGVAVGVVLHDLNQAAAVADEVVLLHNGRIRATGTPAQVFTETDLTETYGIRIEVATDPLTGLVTTRPVGRHLTRIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH85</accession>
    <name>F4FH85_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732530.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13755"/>
    <dbReference type="EnsemblBacteria" id="AEB43863">
        <property type="protein sequence ID" value="AEB43863"/>
        <property type="gene ID" value="VAB18032_13755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13755"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004442_0_0_11"/>
    <dbReference type="OMA" id="PVTVCLY"/>
    <dbReference type="OrthoDB" id="855791at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="279" mass="31550" checksum="8C8DD23D14BB3CA9" modified="2011-06-28" version="1">MHHANHFYGHAHVLARYAGLGDGHPPRINGYVQHGWNIGDGLAPGHPYAEGTPSLLWSEQTRRRAWSVGRRNVTVIGAPFGYLLAMRPEPQSPPQRAGTIWYPFHGWEGQHVEGDHDRLIAQIRQTEPGPVTVCLYWHEHRMRRVRRRYENAGFRVICHGYRGHWWSGTDPDFLDRQLTELRRHARVASNRLTSAVFYGIAAGCEPAVYGNPMVLAGEDPTFGGTARIRRQWPELHGEQVHLPTAVEIARAELGVDHRYPPAALRELLGWTAAVQEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHC8</accession>
    <name>F4FHC8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_13970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732573.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13970"/>
    <dbReference type="EnsemblBacteria" id="AEB43906">
        <property type="protein sequence ID" value="AEB43906"/>
        <property type="gene ID" value="VAB18032_13970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13970"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749932_0_0_11"/>
    <dbReference type="OMA" id="WDARILC"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="37"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="177"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="369" mass="39738" checksum="85013F7C89BA5112" modified="2011-06-28" version="1">MHVVHAFADSRLVSGVNQSVWQLSAAQAAMYPDSQVTVLTFDPRATAPPGVRVVLVSPHSVPAVLARLRPDVLHLHSVLRPTLTIATLAARRLGVPVVASPRGGYAPRAIARRNLLKRSYTRSVELLRMRHTQLFLALTDREGRDIRALYPDAIVRTVGNGIAPLVAAPVAGQHPPHRRPSLIYLGRPDVEHKGLDRLMRLAAELPEAEVLMYGDGLERLHRDGPVPTNVRLMGVAAGPEKAAALIGSSCYVHLSRWEAYGRSIVEAMGLSVPVAISAECDLADEIRRLGLGLVLADADDAGGSARALRRYLDSPLAEQSTRRAREWALTEATPSAVAQRIAQAYAAVIPDAAEPSDVGPSGRNSIINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHF5</accession>
    <name>F4FHF5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733782.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20125"/>
    <dbReference type="EnsemblBacteria" id="AEB45127">
        <property type="protein sequence ID" value="AEB45127"/>
        <property type="gene ID" value="VAB18032_20125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20125"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104523_0_0_11"/>
    <dbReference type="OMA" id="CFDRLVI"/>
    <dbReference type="OrthoDB" id="1489088at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313065" evidence="1">
        <location>
            <begin position="28"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="21051" checksum="FFF513EBA8F84F2E" modified="2011-06-28" version="1">MRISRTLAALTVACAVLLTTAGTTATAGTTATAGTRAAATATGEPYCGITWGSGDKVAGALSDAPLTEVRTGRHDCYDRVVFEFDGTVTGYSVGYGETYTEGEGLALSPYTAGGALLRVSLRAPAYDDEHLATVPYRVGDHVANVLRYQTLRDVVFGGSFEGYSTFAVGVRARLPFRVLVLAGPGTHSRIVLDVAHQWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHF7</accession>
    <name>F4FHF7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20135"/>
    <dbReference type="EnsemblBacteria" id="AEB45129">
        <property type="protein sequence ID" value="AEB45129"/>
        <property type="gene ID" value="VAB18032_20135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20135"/>
    <dbReference type="eggNOG" id="COG0116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070253_0_0_11"/>
    <dbReference type="OMA" id="GHNRIYF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="135"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="37361" checksum="142D6AB20AFCCD2C" modified="2011-06-28" version="1">MLILPSSNRVYSGAAVELTRAELEIFGGAVLGGRLGAVETTTVGGVPYVTFGVEGGLGERDVALLSNLSSAYAIFEFVDDLLRPVPLTRLDRYDDDLVTIQKYPGKTNEQFTKLLLNVTLLASTWADELLTRRFRVIDPLCGRGTTVNQAMMYGFDAAGLDRDSKDFEAYQTFLSTWLKRKRVKHRVLESGPVRRERKVVGRRLRLEVAASKEAHKAGDVQTVDVVNADTTRIGEFFRPESVDLVVADAPYGVQHGSRTADGLARDPLALLAAAVPGWARLLRPGGALGISWNTNVARREAAAEHLTAAGLTVLDDGPWRTLSHRVDQAIVRDILVAQKPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHH5</accession>
    <name>F4FHH5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_20235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733802.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20235"/>
    <dbReference type="EnsemblBacteria" id="AEB45147">
        <property type="protein sequence ID" value="AEB45147"/>
        <property type="gene ID" value="VAB18032_20235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20235"/>
    <dbReference type="eggNOG" id="COG4779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_1_11"/>
    <dbReference type="OMA" id="AWKRGVH"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="34292" checksum="BCFB804481EE86EE" modified="2011-06-28" version="1">MIVIRVPGRLSVRLHPRALAVGTTGLLLTLAVGVLAVGHGDYPMSPADVLRTLTGGGSPAEDFIVTQLRLPRLVTALAVGAALGLAGAVFQALVRNPLGSPDVLGFTQGAATGALIVVVVGGSSAALAGAAAIGGVLTGLLIYLVAWRRGVHGYRLVLVGIGVSAILTGVNGYLLTRAPLMEAARAMLWLTGSLDGRGWSDAAPLLAALAVTVPVLLACGPALRMTELGDDAATGLGVPVPRLRMLLLATAVILVSLSAAAAGPVSFVALTAPHLARRLTRAPGTNLLPAAIIGALIIVVADQVALRAFPSQLPVGVVTGVLGGGYLVWLLATQRRAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHU3</accession>
    <name>F4FHU3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_02760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736268.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02760"/>
    <dbReference type="EnsemblBacteria" id="AEB47636">
        <property type="protein sequence ID" value="AEB47636"/>
        <property type="gene ID" value="VAB18032_02760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02760"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_7_2_11"/>
    <dbReference type="OMA" id="FGPVRRY"/>
    <dbReference type="OrthoDB" id="1233189at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="32"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24468" checksum="ACBE5CCFCE59E153" modified="2011-06-28" version="1">MSFRLSYRADPGNPWFSWQYVRDNSDTVLAALRDHTTLTLRAVLIATLIAVPLAVVAYWFRPLTGPIVALTGVLYTVPSLALFAFVAPYLGIGVATVLSVVVLYALLVIVRNTVAGLNQVPAEVREAAEGMGYGRWGRLLRVELPLALPGILTGLRLATVSTVALITVGVVIGRGGLGQIIFAGFNNNFYKAQIMTGTLLCVLLALVLDLLLVGVGRLLTPWLRGRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHV7</accession>
    <name>F4FHV7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M23B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02830"/>
    <dbReference type="EnsemblBacteria" id="AEB47650">
        <property type="protein sequence ID" value="AEB47650"/>
        <property type="gene ID" value="VAB18032_02830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02830"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037105_0_0_11"/>
    <dbReference type="OMA" id="GKGGCGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307754" evidence="2">
        <location>
            <begin position="26"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="246"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="378" mass="39777" checksum="0940BDB8E0C8E37A" modified="2011-06-28" version="1">MRIGALAAALTATLAFLCCTGGAGAFFLTELGGDAAEQITPASLECTGDFTVEVTGKMPRIPQYGERQLRNAAVIIKVGQDMKVPARGWVIAVATAMQESRLLNLANRTVAESQDIPHEGVGADHDSVGLFQQRASWGTVAQRMNPEYASRKFYEKLVDLPDWQKLPLTVAAQRVQISAFPDAYAKHEELAARIVDALAGGAARTALIAGQEVCDAAASGEIAASGWTAPIPGGVGSGFRTASRPGHNGVDIAAPKGTLIRVAATGRVLVSRCDPDWRGRLSCDVDGWPNKGGCGWFVDVLHAQGIVTRYCHMVSRPRVAAGETVEAGQVIGEVGSSGNSSGPHLHFEVHTDGDRSSRSAIDPVPFMRSKGAPLKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI25</accession>
    <name>F4FI25_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative plasmid partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_30129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AB-18-032</strain>
            <plasmid evidence="4 5">pVMKU</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713111.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30129"/>
    <dbReference type="EnsemblBacteria" id="AEB47989">
        <property type="protein sequence ID" value="AEB47989"/>
        <property type="gene ID" value="VAB18032_30129"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30129"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052816_2_0_11"/>
    <dbReference type="OMA" id="WADGVAC"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="31"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="33401" checksum="0BFE791FF4C9F535" modified="2011-06-28" version="1">MAGKRINLSDLATEPALPEARLPAFAEAAPRTARVQQIAPNPLNTRDLESDRAKIESIAESMRTHGQLQPCAVVSREAFLHIYPEHEAAIGRALWVQVTGGRRRAAALAAGLPTLDIVVKKEPAESRKAWVSATAAENLDRENLDPIEEARAIQLLVEECGSGKAAAEQMSRTPAWVTQRLNLLKLAPEVQALVRTGEVPLREVRDLHQVALEKQLEELRLRREPQPHPPELTAVNSDPAGPVAPTNEKTARPRRSGVTSAIKRLGGTPDRIAASLREELPEEDLQVLAHLLLNGTAAPPNQGAGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI70</accession>
    <name>F4FI70_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zeta toxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_30354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 6">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AB-18-032</strain>
            <plasmid evidence="5 6">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713156.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30354"/>
    <dbReference type="EnsemblBacteria" id="AEB48034">
        <property type="protein sequence ID" value="AEB48034"/>
        <property type="gene ID" value="VAB18032_30354"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30354"/>
    <dbReference type="eggNOG" id="COG1100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043074_0_0_11"/>
    <dbReference type="OMA" id="ARKWLAM"/>
    <dbReference type="OrthoDB" id="1951670at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta_toxin" evidence="4">
        <location>
            <begin position="32"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB48034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="38349" checksum="C4D729526978C9A7" modified="2011-06-28" version="1">MPIDPRRYLLPEHESQRIFHDEIAPEELAHGVPQDQPVVVFVAGQPGAGKTMTTLSVKRELDRRGGAIVVNSDFYKPYHPEYSRLLREDDRNAAPYTSMDGRRWMAAAEHYLIERRVDTIIETTMRDPGDFLEPAAMFRAAGYRAEAAIMAVPEPLSRLGIVHRYHDQVRDLGHGRLTARDNHDASYRGVLQAAEAIDRDRVVDVATVYRRGNHQLHMNYLDAAGTWRWPAGAASAIDAERQRPWNPDETKAFADTVRLLADQMGREWHSEFQDIVRLAAPLADPYTPLPDITHVASGITAAARAFPTSTRQSLPLQPAERTAVAPPPRASQEESRGEEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F182</accession>
    <name>F4F182_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase groes domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_14030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732585.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14030"/>
    <dbReference type="EnsemblBacteria" id="AEB43918">
        <property type="protein sequence ID" value="AEB43918"/>
        <property type="gene ID" value="VAB18032_14030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14030"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_11"/>
    <dbReference type="OMA" id="GYPGNQA"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="189"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="42533" checksum="AED455CE868B1A0A" modified="2011-06-28" version="1">MRALTWQGKRDVRVEEVPDPRIEEPTDAIVRITSTAICGSDLHLYEVLGPYLKPGDVLGHEPMGIVEEVGAGVTRLKPGDRVVVPFNIACGSCWMCSRQLYAQCETTQVTSEGKGAALFGYTSLYGSVPGGQAEYLRVPHAEFGPIKVPETGPDEQWLYLSDILPTAWQAVKYADTPRGGTLAVFGLGPVGQFCARVGRHLGAERVIGLDVVPERLEMARRHGVEVLDVSQIDDVPGTLIDLVDGRGPDAVIDAVGMEAHGAPLGKIAQTAAGLLPDKLAGQMIDKAGVDRLVVLKAALKAVRRGGTVSISGVYGGEVDPLPLMEMFDRGIQMRMGQCHVRRWTDEIIPLLADDSDPLGVTDLRTHRMPLAQAPQAYEMFQRKEDGCVKVVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1D8</accession>
    <name>F4F1D8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_14310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732641.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14310"/>
    <dbReference type="EnsemblBacteria" id="AEB43974">
        <property type="protein sequence ID" value="AEB43974"/>
        <property type="gene ID" value="VAB18032_14310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14310"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="OMA" id="ALRWCGT"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="18"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="477" mass="48282" checksum="850C36C94CC3EF24" modified="2011-06-28" version="1">MYTVAQLIGGVWGAGGDDGEFVVCDPSDGSRVSTAPIAIADEVGKAVAAAREVTAQWAATAPAERAAALHRAADAVAEAADELAQATTAEMGKPLADARGGVDAGIGTLRQYAELAATRGGRTLHGDPAALDFMAPEPRGVVAVITPWNDPVAVACGLLGAALVTGNVVLHKPSERTPATGWLLARAFDTALPAGVLSLLTGGPETGAALAAAEVDVVAHVGSTATGRAIAAAAAAGGAKVLLENGGSDPLIVDADVDPVWAAGQAAQGAFANAGQICVAVERIYVHRDIAEDFVDALVERAAALRVGPGRDPDTELGPLVDRRHRDQVHGQVTAAAADGARIRVGGTLPEGPGAFYPATVVDNCRHDLTLVREETFGPVAPVVVVDSFSEALRCAADSPYGLAATVLTGSMSHAQRAWRELPVGTVKVNAVFGGAPAGAAHPRRGSGQGFGYGPELLDEFTAMKAVHIEAPGGGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1E5</accession>
    <name>F4F1E5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoheptose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14345"/>
    <dbReference type="EnsemblBacteria" id="AEB43981">
        <property type="protein sequence ID" value="AEB43981"/>
        <property type="gene ID" value="VAB18032_14345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14345"/>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080999_0_1_11"/>
    <dbReference type="OMA" id="DVHICVP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="35"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="234" mass="24354" checksum="27183E904C1A34C8" modified="2011-06-28" version="1">MPAATLLERHLANLAAALPPYQRCEPLLARWGATLAQRLTAGGRLLVAGNGGSAAEAQHLTAELVGKLRDDRQPLSAIALHAETSALTAIGNDYGYDEVFARQVRAHGRPDDVLLLLSTSGGSGNLLAAARAGREAGLRCWAFTGPAPNPLADACHEVLAVESSDSQVVQELHLVSSHLLCEYVEQAMPEHTGGTTPRYVEPQVPAVSSAPAEGPVRAGVEVVLDGGAGRPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1H5</accession>
    <name>F4F1H5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733858.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20520"/>
    <dbReference type="EnsemblBacteria" id="AEB45204">
        <property type="protein sequence ID" value="AEB45204"/>
        <property type="gene ID" value="VAB18032_20520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20520"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_11"/>
    <dbReference type="OMA" id="HNLDRDP"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="131"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="36637" checksum="F9974F438D0CF9D0" modified="2011-06-28" version="1">MAVSNTPVLFRPPDHPALPGGPIAVTEAWLRNRRLSEHTRDAYRRDVANWLAWCTDRHLDPLRVNFLHVNEYARTLESTLVARTGRPLTPATVARRLSALSSWYDFLVKLRAVDTNPVADADRPRVDRDHSATIGLTPDEVDALLTAADADTGPTAARNRAAIALLADLGLRVGELVALDITDLGAERGHRSVRFVGKGGKARRRALTPSTAHAVDTYLAQRAAAEGVQVNELTGPLLVTASGARLDRHSVFRLVRRLARSAQIPAWAHLSPHSLRHAFATTARAEGVPLEDVQDAMGHADPRTTRRYDRDRHNLDRDPAYVIWAARARRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1P0</accession>
    <name>F4F1P0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735116.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26961"/>
    <dbReference type="EnsemblBacteria" id="AEB46465">
        <property type="protein sequence ID" value="AEB46465"/>
        <property type="gene ID" value="VAB18032_26961"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26961"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099330_0_0_11"/>
    <dbReference type="OMA" id="ASWLHEY"/>
    <dbReference type="OrthoDB" id="1900556at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="23927" checksum="F3EAF9BBF070CBAC" modified="2011-06-28" version="1">MVGRQLNWNEYATAWARLHGGFDPRAATPVVRAWLRLSYHLGFLLGRLRVGPTAVTAVGVLLCLCVPLFAVRAGDGPFLGALFVLLASVADSVDGAVAVATGRTTRLGYVYDSLADRIGEVAWLVAFWLVGAPGALVAAAGALSWLHEYVRARAVAAGMREIGAVTVGERPTRVCVALVGLLLAGLTGLIQPDLAAGTITMATAVWVLLAAFGLGQLLSAVRRALIDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1P9</accession>
    <name>F4F1P9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_27006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735125.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27006"/>
    <dbReference type="EnsemblBacteria" id="AEB46474">
        <property type="protein sequence ID" value="AEB46474"/>
        <property type="gene ID" value="VAB18032_27006"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27006"/>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_14_4_11"/>
    <dbReference type="OMA" id="QRFTDMV"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307323" evidence="6">
        <location>
            <begin position="30"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="167"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="535" mass="56355" checksum="0F1D45E02866BFEF" modified="2011-06-28" version="1">MKRSLRRALWVGAVVAVTVASVPMATAFGAGSVTTSFTRVQDWGTGHETRVTITNGSSASVSTWRIEFELPSGTSISSSWDADVTRNGNRYVAVKKSWAGALAPGASFSWGYNGTGAYRAPLNCTVNGAACGGGTPPPTSPPPPTTTAPPPPTSPPPTTPPPPPGGQKVVGYFAQWGVYARNYHVKNIHTSGSASKLTHILYAFGNTTGGRCTIGDSYADYEKAYTAAESVDGVADTWDQPLRGTFNQLRKLKRMYPHIKVIWSFGGWTWSGGFTQAAQNPTAFAESCYNLVEDPRWADVFDGIDIDWEYPNACGLTCDASGPNAFKNVAGALRTRFGSSALVTAAITADGSNGGKIDATDYAGAATHLNWIMPMTYDYFGAFNAQGPTAPHSPLYSYSGIPQQGFWSDAAIQKLKSKGIPANKLLLGVGFYGRGWTGVTQSAPGGSATGPAPGTYEQGIEDYKVLKNTCPATGTIGGTAYAKCGSNWWSYDTPSTIGGKMTYAKNQGLGGAFFWELSGDTSNGELISAIRNGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1U8</accession>
    <name>F4F1U8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide 4</fullName>
            <ecNumber evidence="10">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_27251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associates with subunits I, II and III to form cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735173.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27251"/>
    <dbReference type="EnsemblBacteria" id="AEB46523">
        <property type="protein sequence ID" value="AEB46523"/>
        <property type="gene ID" value="VAB18032_27251"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27251"/>
    <dbReference type="eggNOG" id="ENOG5032TTI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145919_0_0_11"/>
    <dbReference type="OMA" id="GTYFRFV"/>
    <dbReference type="OrthoDB" id="1844113at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017385">
        <property type="entry name" value="CtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB46523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="142" mass="15646" checksum="23EB22CA3245D126" modified="2011-06-28" version="1">MKTEWRIFLTIAAFLLFAAVLYGGWTWADSGGRVEWIGTVALLLSFLLCSMCGGFFWFVSRRIDLRPEDRPDGEIADGAGEIGFFSPGSYWPFGLALAATIAGLGLVFWQMWLLGLGAVAVIFAACGLLFEYYSGTRRTAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1W2</accession>
    <name>F4F1W2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735187.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46537">
        <property type="protein sequence ID" value="AEB46537"/>
        <property type="gene ID" value="VAB18032_27321"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27321"/>
    <dbReference type="HOGENOM" id="CLU_719510_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="384" mass="37849" checksum="839FBC3A7EBE3505" modified="2011-06-28" version="1">MRVDGARPIAVRVDGAGPVAVGVDVVWLALLWGGGDRAGTPGGRGDGLLGHHRQVTAGRVVVGGGRDGTVGVGPLRGRPVQVALRPGPGRGGRSPGLASGAVAGVGYDGTLVLPVVSTGARAQRPRLGPGEVAARRFGVPLGVSDSRLGAGELRRPVGAGLLVVRPTGWLVVDVTVGVRGSIGVTDGELLPIAVHPRPVVVAGLTGVAAPLVAGTPRVVGGGAAVGVLDGSVHGGAAGFPAGLGCPTALRSPGRRPGRATPVRIAVGRLGSTWALGMPVGIAVAPLRIVVRIAVGPTWVRLAAVGLASVGLPPGVPVGGVSLGRLEAATVPAIPVRRVPVDVGLGVPLTDALVALDRRAGDTGRLWTGVGPGDTVASAYRLDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F202</accession>
    <name>F4F202_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03325"/>
    <dbReference type="EnsemblBacteria" id="AEB47749">
        <property type="protein sequence ID" value="AEB47749"/>
        <property type="gene ID" value="VAB18032_03325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03325"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811196_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="33527" checksum="F174F0230D38C3C6" modified="2011-06-28" version="1">MVFTPAQPLAPAGPVTSRSGGSLRPHLIWEAVLLALTVVAAVVWYSQDGSRLSPLVFNIASAGLLATAFALSLRTATPNLAVVAVAALAGLTYAEVLDAGAPVLVAAVAAIAAAAFFGLGMGLVAGLLQAPGWAVSLGGLALAQGILLATTGSGGPRRLASEGWIRSDGAGAGWLVLFLLLSIGGAVVWSIPAVRRALSGNRVVAGEPPSPFGARLLGAVIGLGGSSLIAGAAGVLLAGRIGATTLSADNGQLAFVAGAVLLGGVSVAGGRGGFAGTVLGVALLSLVQMTILVADGPRWLSTVVFALAVLAGLGVSRALEALQPALPARVPGAGPAEPSRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2M6</accession>
    <name>F4F2M6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20955"/>
    <dbReference type="EnsemblBacteria" id="AEB45291">
        <property type="protein sequence ID" value="AEB45291"/>
        <property type="gene ID" value="VAB18032_20955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20955"/>
    <dbReference type="eggNOG" id="ENOG502Z7QC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062259_0_0_11"/>
    <dbReference type="OMA" id="VTLNFHP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022074">
        <property type="entry name" value="DUF3626"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12294">
        <property type="entry name" value="DUF3626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="37108" checksum="232C7B9D46F435CF" modified="2011-06-28" version="1">MALRDRPDARAIIGRLLTDVRADPAHLVEAIGHDGRITLNFHPDRLLADGRSVAQALAAQGVYRSQFETGISNGGLTAYPGGDRDRWEQQMFGGAYQRPGVRPAERPKYGGLNLLDHPDGAAVRFGSCHLRLRPEVRHRTTFCFGDSHLGPRDVGTAEVFEPVLAALLAATVDTGVCLGRPGMNLVDLTAYLLRRREDLAAAAAGRALDDYVEAQVHGELHLGRDVQELVADPSFRGTAVGADLATAARRYGFRLRWHAGFVLPVDQVDADFRGPAMVPLAARVHAEFARPGEPLTAALIGRAAASVVTDPARWADRGPVTDTRQHLKQLWHVLVRFGVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2P0</accession>
    <name>F4F2P0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21025"/>
    <dbReference type="EnsemblBacteria" id="AEB45305">
        <property type="protein sequence ID" value="AEB45305"/>
        <property type="gene ID" value="VAB18032_21025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21025"/>
    <dbReference type="eggNOG" id="ENOG5030ZWG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122393_0_0_11"/>
    <dbReference type="OMA" id="WPRNEIM"/>
    <dbReference type="OrthoDB" id="1834111at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="18514" checksum="E2BBDDFBF00DF19E" modified="2011-06-28" version="1">MRGKLIWLALVGLTWAAMMSFGGVAAETVMLYPNIFHDPPASLERAREFLAVSGPSDYFPPLGASVVLLSVAATVLSWRQRGLRWWIAAATVVFVACEFLFSVVFFWPRNEIMFVDPAGTHSPEYLRQVADEFVAGHWVRLAGGAVTAALSFTALLRWARTDQRQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2X9</accession>
    <name>F4F2X9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27586"/>
    <dbReference type="EnsemblBacteria" id="AEB46590">
        <property type="protein sequence ID" value="AEB46590"/>
        <property type="gene ID" value="VAB18032_27586"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27586"/>
    <dbReference type="eggNOG" id="ENOG503068I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127668_0_0_11"/>
    <dbReference type="OMA" id="ADRVEHE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="15823" checksum="954AFDC7BF8978B6" modified="2011-06-28" version="1">MDDEHSRPTGVDDTTVEALGELSKALETIHRVRGHLYSAHQLVGGADLTLDRVVTLLREAGHDAVADRVEHELLGRNVLPGRWTFQIMEEFDDGYYAAFQEIERYARDTLADGRRHIYEAEMKQRRRTHGMAGHEATPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Y2</accession>
    <name>F4F2Y2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46593">
        <property type="protein sequence ID" value="AEB46593"/>
        <property type="gene ID" value="VAB18032_27601"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27601"/>
    <dbReference type="eggNOG" id="ENOG5031WHQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2195813_0_0_11"/>
    <dbReference type="OMA" id="GWIAVPM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="108" mass="12162" checksum="5EF291949AD6D256" modified="2011-06-28" version="1">MFGVVVPSIIIRELIEGAMGSGPLADLGWIAVPMAATAWLAPRASYRRRDALWWLAGGFGLYIFVVIAWRVAFLPYRDWPPRPDEASRIRWLCDRQQAGLWYLSGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F301</accession>
    <name>F4F301_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735262.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27696"/>
    <dbReference type="EnsemblBacteria" id="AEB46612">
        <property type="protein sequence ID" value="AEB46612"/>
        <property type="gene ID" value="VAB18032_27696"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27696"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092691_1_0_11"/>
    <dbReference type="OMA" id="INMKARD"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="136"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="245" mass="26773" checksum="14C083AC7618E229" modified="2011-06-28" version="1">MATRLVQINMKARDDAALGRFWAEVLGWGVSSEGPRVTNLEPEDSVYPDPVAVCIDLVAYPDDPKTVKNRVHIDLATTSAAHHAELIAQLTELGATPADIGQGDVPWTVMADPEGNEFCVLDWRTSPRDTGPIAAIVADCTDPRAMVDFWGNAMDWTVHEVNDDHAVLRSAKGVGPYLRFVRTPDVKTVWNRVHLDVRPYPGDDLAAEAARLRALGATSIGLDGDVHWMVLADPEGNEFCLLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3F2</accession>
    <name>F4F3F2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aig2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08790"/>
    <dbReference type="EnsemblBacteria" id="AEB42876">
        <property type="protein sequence ID" value="AEB42876"/>
        <property type="gene ID" value="VAB18032_08790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08790"/>
    <dbReference type="eggNOG" id="COG2105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048475_4_0_11"/>
    <dbReference type="OMA" id="APHDYVM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="14780" checksum="8A4616788CBE2CA0" modified="2011-06-28" version="1">MRAYCPHSPMVGIGWLEGWRLTFAGEDVIGWEGAVSTVVESPGDRVFVALYDIHPYDAAQLDEIEGVTSGTYRKLTVRVSTLDGDVTAWVYVFDGYEGGLPTSWYLSEIANAAEKAGAPDDYVLELRSRPTGTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3G3</accession>
    <name>F4F3G3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nad-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14795"/>
    <dbReference type="EnsemblBacteria" id="AEB44071">
        <property type="protein sequence ID" value="AEB44071"/>
        <property type="gene ID" value="VAB18032_14795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14795"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_2_1_11"/>
    <dbReference type="OMA" id="CPVHVAD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="1">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="235" mass="24757" checksum="75F49BF700A47272" modified="2011-06-28" version="1">MRVPGVVVRRVDVTDRSAVRALVADVRPDVVVNASYRYDAWAVTADGAAHVAGAAAEVGARLVHMSSDALHAGRPEAYADDDPPTPIFPYGAAKAAAETVVRALDPSAVLVRTSLIVGQGSKQIQLCRDALAGRATLFTDELRCPIDVTDLAAAVVELVGSDYAGTLNVAGPEAVSRAELGRLVAHHQGLDASALKTTTTVEYGLVRPTTIRLDTTRATTLLRTRLRGITELLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3X7</accession>
    <name>F4F3X7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_27751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27751"/>
    <dbReference type="EnsemblBacteria" id="AEB46623">
        <property type="protein sequence ID" value="AEB46623"/>
        <property type="gene ID" value="VAB18032_27751"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27751"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_11"/>
    <dbReference type="OMA" id="DWVYVVP"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="401"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="444" mass="48463" checksum="10C7AA77E35B5610" modified="2011-06-28" version="1">MPSFPAGFRWGVSTSAYQIEGAAGADGRGPSIWDTFAHSPGRIVDGSSGDVACDHYHRYAEDIALMAELGVTAYRFSVAWPRVRPTGSGAVNPAGLDFYERLVDGLLERGIDPVATLFHWDLPQPLEDAGGWLNRDTAHRFAEYADLVAERLGDRVKLWITLNEPFIHMSLGHGTGEHAPGRALLFDAFPVAHHQLLGHGLAVTALRARTAAPVAIANNYSPVRAAGDGPADRSAVAAYEALHNQLFTDPLFGRGYPTELGFDQSAVRDGDLDVIAAPIDVLGVNYYNPTGVRAPEDGSPLPFELVPLDGYPRTAFDWPVAPDGLRELLGWLHGRYGADLPPVQITESGCAYDDEPDADGRVHDPDRIAYLDGHLRAVRAAVDDGVDVTGYFVWSLLDNWEWAEGFTKRFGLVHVDYPTGRRTPKSSYAWLREVIATARRDTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Z3</accession>
    <name>F4F3Z3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27831"/>
    <dbReference type="EnsemblBacteria" id="AEB46639">
        <property type="protein sequence ID" value="AEB46639"/>
        <property type="gene ID" value="VAB18032_27831"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27831"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073856_0_0_11"/>
    <dbReference type="OMA" id="SSGWKSY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307399" evidence="2">
        <location>
            <begin position="34"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="361" mass="37636" checksum="81EB70FCC6A39240" modified="2011-06-28" version="1">MATVKPAARTAALICAALALAVGVALVPGPAAAHGLLAAAPADVGDEGGTPALRAQLEAASKGYLDAKAALDRSVKRQKQLAAQLTTTENQLTERGAKVAEIAAQAYRSGRLGAASALLNSGSPAGFMDRAAALDAVAANEERALGELRATRDEVSRTKQALDVEVQEQRKQVAVMAKRKDQAERALTVANERAEAAERAQAAERAARTPSRGGGSSPTAKPAPRNSDGSWPSESCSVNDPTPANGCITPRTLHALNQAKAAGFTRYVSCYRSGGSGEHPKGRACDFAAQKNGFGGVATGGDRTYGNNLAAYFVNNADRLAVLYVIWYKQIWLPSSGWKSYSGGRGDPSSDHTNHVHLSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F452</accession>
    <name>F4F452_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, gntr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736497.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03915"/>
    <dbReference type="EnsemblBacteria" id="AEB47865">
        <property type="protein sequence ID" value="AEB47865"/>
        <property type="gene ID" value="VAB18032_03915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03915"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_11"/>
    <dbReference type="OMA" id="WRKIYKH"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="364" mass="39412" checksum="583631ACFE4A1B55" modified="2011-06-28" version="1">MTAEQLISFARGAPSLDIVDVEGLKAAAVRAFDADPTGVTAYGTSVGYLPLRKWIAEKHGVEADQVLITNGSLQADAFLFDHLVRPGDAVVVERPTYDRTLLNLQRMGSELHGVTIQPDGLDTAELRKLLESGVRPRLAHIIPNYQNPAGVTLSLDKRRELLELAAEYGFTIFEDDPYADIRFRGEPLPSMLSMDTRGVVVHASSFTKTVCPGVRVGYLVGPADVIGAIASKATSLYISPGMVAQAIVHQFCVSGDIERSIETVRAALGERARVLAESLRRHIPEARFVEPDGGYFLWVELPEDVDVEKLAPAAAERGVAVVKGSDFVIDGGRHALRLAYSAVTADRVDEGVRRLAEAMEAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F473</accession>
    <name>F4F473_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_04020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736518.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04020"/>
    <dbReference type="EnsemblBacteria" id="AEB47886">
        <property type="protein sequence ID" value="AEB47886"/>
        <property type="gene ID" value="VAB18032_04020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04020"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_11"/>
    <dbReference type="OMA" id="PKVKYLN"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="14"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="35392" checksum="A49C6788EEA463A5" modified="2011-06-28" version="1">MKVEQRFGPGHRVLVTGGAGFVPSHLVDALIARGCTVVAVDNFVTGSKENVAHLLDAPTFTLVEADISDGLPDHPALAERFDAILHMASPASPTDFEKLPVEILRVGSVATLHLLDRAVADGARFLLASTSEAYGDPKEHPQRETYWGNVNPIGIRSVYDEAKRFSEAATMAYRRSRGLDTAIVRIFNTYGPRMRPDDGRAIPTFISQALRGEPITVHGTGNQTRSICYVADLVRGILLLLDSTESGPVNCGTEHEVSMRELAETIVSLCGSSSEVTYVTRSADDPEMRRPDLSLAREVLGYEPTVTPEIGLRRTIDHFRERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F484</accession>
    <name>F4F484_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736529.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04075"/>
    <dbReference type="EnsemblBacteria" id="AEB47897">
        <property type="protein sequence ID" value="AEB47897"/>
        <property type="gene ID" value="VAB18032_04075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04075"/>
    <dbReference type="eggNOG" id="ENOG5033CCQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1738421_0_0_11"/>
    <dbReference type="OMA" id="MPHIELE"/>
    <dbReference type="OrthoDB" id="1795668at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="15761" checksum="1DE9CBE309D95F93" modified="2011-06-28" version="1">MAHVELSLSEVFAPTTGTPTEQECDNIGRWSATVSSADEPCLLIDDQTRVVAVSAAGCELLCLGTPEELIGLPLLDGGLRLLDFTANRGELTEPEIDKIPPLLALTSGRLARGLLRIESATVGGPDATVDAVSTPVLADGAVAGSLTFFSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4D3</accession>
    <name>F4F4D3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731562.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08865"/>
    <dbReference type="EnsemblBacteria" id="AEB42891">
        <property type="protein sequence ID" value="AEB42891"/>
        <property type="gene ID" value="VAB18032_08865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08865"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_11"/>
    <dbReference type="OMA" id="NIDYKAY"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="23601" checksum="3EE249BF1F1CDC3C" modified="2011-06-28" version="1">MTVTLVTGANKGIGFETARQLLELGHAVYLGARDIERGKAAAAALGAPFVQLDVTDDASVSDALATIDAAEGRLDVLINNAGILGSGDIDGPKALRVFDTNAVGIVRVTEAALPLLRKSSNPTVVNVSSSMGSFWAVNNPERPEFGIPMALYAASKSAATMLTVQYAKLHPGIKFNALEPGTTATDMTADLGIGRPVEESAKTVVRLATLGVDAPTGTLTDDHGTLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4F9</accession>
    <name>F4F4F9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731588.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08995"/>
    <dbReference type="EnsemblBacteria" id="AEB42917">
        <property type="protein sequence ID" value="AEB42917"/>
        <property type="gene ID" value="VAB18032_08995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08995"/>
    <dbReference type="eggNOG" id="ENOG5030Q2B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2025082_0_0_11"/>
    <dbReference type="OMA" id="EWHAWRT"/>
    <dbReference type="OrthoDB" id="1728664at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="114" mass="12567" checksum="DC3BD345CEC495C6" modified="2011-06-28" version="1">MTELATRAQAFGLIAEGVAAGLSAPWRLYLARGCRYLSLSVGDRTEWNAWRTHLGCPELSVRVYDAGGEIRRSSVAEVVLDGCRISVELVEEVGTDDLDRLLMTDPTTVEPEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4H4</accession>
    <name>F4F4H4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ordered locus">VAB18032_09070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09070"/>
    <dbReference type="EnsemblBacteria" id="AEB42932">
        <property type="protein sequence ID" value="AEB42932"/>
        <property type="gene ID" value="VAB18032_09070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09070"/>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023625_2_1_11"/>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="133"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="331"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="407" mass="44320" checksum="7575ADE299F210DE" modified="2011-06-28" version="1">MGDGGVAVSSSEEPWPVRVVSQKIAAWVARLGWVWVDGQVAQISRRPGASTVFLTLRDPSAELSLTVTTDRDVLDSGAPELREGARIVVHAKPEFYAARGTLSLRADEIRQVGLGELLARLEKLKKLLAAEGLFDRARKRRPPFLPQRVGLITGRASAAERDVLTNARRRWPAVEFRTVNVAVQGPGAVPQIIDALKVLDSDPSVDVIILARGGGGIEDLLPFSDEALCRAVFACRTPVVSAIGHETDAPLVDYVADIRASTPTDAAKRVVPDLAEEIRLINQARHRLHRAVHNLVDRETHRIDALRSRPVLARPQVMVEQRAADLAALRQRAERNLRHRLAAADDDLRHTLARLRALSPAATLDRGYAIVQRADGHVVRAADEVAKGDALRVRLADGDLAVTVTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4I9</accession>
    <name>F4F4I9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase U61 LD-carboxypeptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_09145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731618.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09145"/>
    <dbReference type="EnsemblBacteria" id="AEB42947">
        <property type="protein sequence ID" value="AEB42947"/>
        <property type="gene ID" value="VAB18032_09145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09145"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_1_0_11"/>
    <dbReference type="OMA" id="VEYPTTR"/>
    <dbReference type="OrthoDB" id="952832at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="3">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="4">
        <location>
            <begin position="205"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="346" mass="37976" checksum="EEA9978F981119A6" modified="2011-06-28" version="1">MAALIYPPKPRPGDRVAVVSPSAGLPAIFPHVYELGLRRLREEFGLQPVEYPTTRIMGADPRERARDLTAAFADPSITAVLATVGGDDLITVTPYLDDEVLQANPKPYFGYSDNTNVLNHLHRLGMVSYHGGSVLVHLGRPGTLHPLTADSLRAALFGSDWYDLSPAPQWGDEPNDWNDPDCLADEPVMFPGTGWHWQGPARVVEGRTWGGNLEVLHWLLAADRVAPAESLHGSVLLIETSEELPPAVEVYRMLRNLGERGLLAGFPAALIGRAKAWEFGRRLTPPEKAAYAQQQRAAVSRAFAEYAPDAVLVFDVDFGHTDPQLIIPYGGLARVDPLARRISVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4J6</accession>
    <name>F4F4J6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731625.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09180"/>
    <dbReference type="EnsemblBacteria" id="AEB42954">
        <property type="protein sequence ID" value="AEB42954"/>
        <property type="gene ID" value="VAB18032_09180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09180"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085342_0_3_11"/>
    <dbReference type="OMA" id="IPYQVQL"/>
    <dbReference type="OrthoDB" id="1711819at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="22854" checksum="AA8025AB60F783BA" modified="2011-06-28" version="1">MHQRRTPGGQRPARRPARPGTGRGTVRDGGVRAQSRAAGRAPSAARGAEGVRSAKRPAARRAAAGGVTRMAAPRPRGLTGRATVLIAVLIALALAYTYPVRVYLDQQADIERMEAAQAAQRELIAELTSQAEKWQDDAYIETKARERFFMRRPGEKMVILLEDPAGAARDAGESGQPTAPVEPDAWYETLWSSVRAADAAQTDAETAPQLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4S4</accession>
    <name>F4F4S4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732881.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15520"/>
    <dbReference type="EnsemblBacteria" id="AEB44216">
        <property type="protein sequence ID" value="AEB44216"/>
        <property type="gene ID" value="VAB18032_15520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15520"/>
    <dbReference type="eggNOG" id="ENOG502ZDRK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171888_1_0_11"/>
    <dbReference type="OMA" id="FINAGPH"/>
    <dbReference type="OrthoDB" id="2065808at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046251">
        <property type="entry name" value="DUF6284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19801">
        <property type="entry name" value="DUF6284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="82" mass="8890" checksum="E7C84EB3F593571B" modified="2011-06-28" version="1">MRKHLVAVTPEPTIADLAAIESEWPLIAAELDVLDAQITLLYAEDQGGPTVLDWRRLRRAEARVTRAAAEVADRATGAGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4W7</accession>
    <name>F4F4W7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734109.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21780"/>
    <dbReference type="EnsemblBacteria" id="AEB45456">
        <property type="protein sequence ID" value="AEB45456"/>
        <property type="gene ID" value="VAB18032_21780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21780"/>
    <dbReference type="eggNOG" id="ENOG5032WAN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228756_0_0_11"/>
    <dbReference type="OMA" id="FIYLGFQ"/>
    <dbReference type="OrthoDB" id="1830999at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="225" mass="24858" checksum="2CA410B75BBF27ED" modified="2011-06-28" version="1">MSYPLPQFVEPEPHGFIYLGFQVEPPRQAPVYTHTPRRQRAAARLVQAVPALLRRPDVASVRIFRAVFIPPLPGAPRYDLATLIRTKHVDDLKAVRTCGEVAALDGEQILAGVNVARIGDTEARTDGVFLLNHFTAAPGTDAEAVWRSVTGWYTTKTAVDNSTALRPTEPSPFALVNYARLPAGPIRFLVGQLTRPSFHRFVRARLDAHGMRALPAFHRLVHTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F569</accession>
    <name>F4F569_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735401.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28401"/>
    <dbReference type="EnsemblBacteria" id="AEB46751">
        <property type="protein sequence ID" value="AEB46751"/>
        <property type="gene ID" value="VAB18032_28401"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28401"/>
    <dbReference type="eggNOG" id="COG2261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160040_1_2_11"/>
    <dbReference type="OMA" id="MISSIIW"/>
    <dbReference type="OrthoDB" id="2084822at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="95" mass="9960" checksum="625A08EFBDBD0D14" modified="2011-06-28" version="1">MELTVWGIITALIVGLIVGALGRLVVPGRQPMPIWLHMLIGVGAALLGTVIARASGFAETAGIDWRELMLQVLLAAIAVALVAGVGRSRRGVTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5W4</accession>
    <name>F4F5W4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734176.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22115"/>
    <dbReference type="EnsemblBacteria" id="AEB45523">
        <property type="protein sequence ID" value="AEB45523"/>
        <property type="gene ID" value="VAB18032_22115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22115"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_11"/>
    <dbReference type="OrthoDB" id="1432010at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="98"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="341" mass="35922" checksum="3D9C0C70DD3F495A" modified="2011-06-28" version="1">MLVELAPHSSDAELASLATRIARHEDVTAWPLRLAGRCFLVVAGDERLVHRVSSAAIRAWHSTAERGYWLVDRANAVLPRRVPLGSGHVGGGDLWCGAGPCALESVSDTVRTATMVRRAGADAVRASLFKVRSGPYHFPGKGRGGLSALAEVRAGGGLPVITEVADPRDVGAVAQVADCLQVDPRNMTNRALLAELGGSGRPVLLMRGVRATVAEWLKAAEYVVSHGNPHVIMCARGVVSFDRSLAYQLDYGAVAAVRRHTDLPVIFDPSHSTGSAAAVAPAALAAAVFGVDGLLIETHPAPERMYRPGDAAQMYPVDRLAALLAACRQVRDLAAGLDAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Y9</accession>
    <name>F4F5Y9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22240"/>
    <dbReference type="EnsemblBacteria" id="AEB45548">
        <property type="protein sequence ID" value="AEB45548"/>
        <property type="gene ID" value="VAB18032_22240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22240"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_11"/>
    <dbReference type="OMA" id="VEGMVEY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="105"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="34054" checksum="B14873F67E69200C" modified="2011-06-28" version="1">MNPRVCVYHPSMGPAITRALQAAHPGVRVDVASDLRTDPPQPETIDVLVANRLPDGLLSRCTRLSWLHLTGTGTDHLAAAGAPPGLRVTTSATVPVRAVAEFAWTAVLALAKDLPRLRDQQHEQRWQLPDARLVAGSRLLLLGLGRIGSAVAELAAAFGVRVTAITRTARPSPLAGTVLPPHVLRAAAADTDHLVNTLPSNPGTRGLVDRQVIEALPDDAVVVNVGRADTVDTAALVDRLRAGRLRGAVLDVHDEEPLPPNSPLWSVPRLFVTPHGAYRFPEEEHAVAKVFLAEFAAWSAAVAPADQGAAGCPYLARTEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F645</accession>
    <name>F4F645_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28631"/>
    <dbReference type="EnsemblBacteria" id="AEB46797">
        <property type="protein sequence ID" value="AEB46797"/>
        <property type="gene ID" value="VAB18032_28631"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28631"/>
    <dbReference type="eggNOG" id="ENOG50324G7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3085997_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="52" mass="5942" checksum="61982C7C343AC761" modified="2011-06-28" version="1">MVYGHHDDVLTYVGPDEISDGSDLAVGLYGRHKRDRDGHELDVVHIEDKRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F683</accession>
    <name>F4F683_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735484.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28821"/>
    <dbReference type="EnsemblBacteria" id="AEB46835">
        <property type="protein sequence ID" value="AEB46835"/>
        <property type="gene ID" value="VAB18032_28821"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28821"/>
    <dbReference type="eggNOG" id="ENOG5032Y20">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083318_1_0_11"/>
    <dbReference type="OMA" id="PYGVAWR"/>
    <dbReference type="OrthoDB" id="1374065at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="240" mass="24813" checksum="6A9610D801795064" modified="2011-06-28" version="1">MSAGGVTPGPGSDTAESRHGLDGVADAGAFLARLVRLEPAALVRLRPTGTPGRTALWGRLPWGVLAVRTVSGPGAGDVTVAAGQLLAELAAGRAGLPARRDAQWRWPLPPAASRPVENLPGEDVRRLAEAAAGTLREAATNGVAGRAVGQRTLRDALLDHVAVVVTPDDAPDRPVEVTQRLVQGLIRMGFLGATGGSSGIDEVRVRAAGRWVALVGPYGAVWSQKATDLAVRPLDPRPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6I8</accession>
    <name>F4F6I8_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">VAB18032_16050</name>
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    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
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            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44316">
        <property type="protein sequence ID" value="AEB44316"/>
        <property type="gene ID" value="VAB18032_16050"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3031190_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="6039" checksum="1A314BF785B7F543" modified="2011-06-28" version="1">METIHLLQARVTMPHLDQATDATWLAMLYDSARALHGVVTPSVEERTVDSNCATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6K5</accession>
    <name>F4F6K5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16135"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="23182" checksum="D39E98DCE3DDDD0F" modified="2011-06-28" version="1">MAGALMTGRLSVWLVPDRADRPSIMRRYAEFVVAQGLAHGTVDTTDDHTAVAIWHPRSTPPPAVRQRDLEPILGPHTARFALLHAYADTVHPFTAHHYLAHLAVAPGQHQAGVGRALLASHHRLLDATQLPAYAEVSTSRPRDGLLAACGYQPRSPILLQQGGPVVWRMWRPPTHPDQAETAGTGLPQRVRVHRTATPFRGRLLRAAPPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6P3</accession>
    <name>F4F6P3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733031.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16325"/>
    <dbReference type="EnsemblBacteria" id="AEB44371">
        <property type="protein sequence ID" value="AEB44371"/>
        <property type="gene ID" value="VAB18032_16325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16325"/>
    <dbReference type="eggNOG" id="COG2197">
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    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="15296" checksum="485832CDE5672835" modified="2011-06-28" version="1">MEAVAVVRRNEPDVVLRDIRMPVMDGIEATRRMVDGMARPPRIIILTTFNVDRYVYAALAPHRVAALVLEERPPPVLLGLAMPSCVPETAPYYDREVRPAVLSGLNAPDPAWWEALATTHHRHIVNDQPLQVRQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6U2</accession>
    <name>F4F6U2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734269.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22585"/>
    <dbReference type="EnsemblBacteria" id="AEB45617">
        <property type="protein sequence ID" value="AEB45617"/>
        <property type="gene ID" value="VAB18032_22585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22585"/>
    <dbReference type="eggNOG" id="COG3559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036785_2_0_11"/>
    <dbReference type="OMA" id="VRHTRQN"/>
    <dbReference type="OrthoDB" id="1885421at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="541" mass="54567" checksum="2279D3071DA6BD2D" modified="2011-06-28" version="1">MSTLTGTGRLARLAVRRDRVRLGIWVLGTPLIGYAIAESVAGLYPDAQTRLGYAETAITSVVARAFNGPIAGTDIGAVVVTESYLTLALLAALLSTFAVTRHTRQNEETGRAELLGAAPVGRYALLTAALVVVVGANVLAAGLLALALVGTGLPVAGSVAAAAAVGGVGVAFTGVAAVTAQLTVTSRGANALAAATVGVAFLLRAAGDVLGERAAAATRLDSAWPVWLSPLGWGTQVRAFGPERLWALALPVALLVACVAVAYLLAERRDVGAGLLAARRGPARAASGLLSPAGLTWRLHRGALAGWAVAVTILGLAMGAAGHEVDAMIAENPQAAEVIAQLGGGAELVDAYLAAMLGIFALTIGAYVVQALLRTRTDESDGILEALLATAVSRTRWLGTQVLGAALGASVLVLLAGITTGLGYGVADGDPVGWTVDLAGAALLRLPALLVVAGVVTALFGTLPRLSVGLSWASLIVFLLLGQLGTVLDLPQAALNLSPYTHVPSVPAADATVPPLLALTAVAVVLLAVGLAAFRHRDTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F703</accession>
    <name>F4F703_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_28981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735516.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28981"/>
    <dbReference type="EnsemblBacteria" id="AEB46867">
        <property type="protein sequence ID" value="AEB46867"/>
        <property type="gene ID" value="VAB18032_28981"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28981"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020567_1_0_11"/>
    <dbReference type="OMA" id="CLKVMGQ"/>
    <dbReference type="OrthoDB" id="374938at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="347"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="725" mass="78354" checksum="2931E70910B32CFD" modified="2011-06-28" version="1">MTSQDDDRFDWRAAERDLTDDAPDTNVVDLDAARTARTTNPDDGDGGPVLVDSPDAQKSPRFTLDGARAGQRRPILPAWLRSRAELVDVMRWAVGHLLHTTGYHVTRLPKYAGKLALRAPAGAARLVSGGTRWLFDWEGEPHRQATSQSRDGELYLKLSRQRDRRVRWRGIVVTFTLAVTLAGGVAVALAPLWARWAVLAMLVTLCGLLGQPADKPLLDTAVVIPRVARLTSDVVVRALAVLGIAGITQAIAKQGQRAIAFTAPITRDGPGWRADIDLPPGVTAGDVIERRDRLAAGLTRPLGCVWPEGQPEVHPGRLLLWVGDQDMAATPPKPWPLLKASGGFDLGRPVPFGTDPRGRVISFELPYTNLLIGSIPGYGKTAATQVPMLAAALDPYAELWCFDFKGTGGLDPLEKVSVRYASGQDDDTAEEGLLALRELRKECQRRAAVIKGLPKAVCPDNKVTPELARRRKLGLHWLVVALDEVQELFSHPEFGKEAGELAEKIIKLGRALGVILVVATQRPDAKSLPTGVSANAGTRFCLRVMGQIENDMILGTSAYKNGIRATMFAKKDKGVGYLVGAADDAQIVRTFYVDGPTAEKITDRARALREAAGTLTGHAIGQTPATPAARRDTLLDDILTVVPATEPKVWAETLTERLADLNPDAYGDLTRDQLTAALKPYGITTGQVWGTDPATGKGANRRGIDRADIADAVAERHRRRGDKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7B1</accession>
    <name>F4F7B1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hesb/yadr/yfhf-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731840.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10255"/>
    <dbReference type="EnsemblBacteria" id="AEB43169">
        <property type="protein sequence ID" value="AEB43169"/>
        <property type="gene ID" value="VAB18032_10255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10255"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173345_1_0_11"/>
    <dbReference type="OMA" id="AIGRQDQ"/>
    <dbReference type="OrthoDB" id="1891602at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="93" mass="9654" checksum="5FA4E66D6104C55F" modified="2011-06-28" version="1">MLTMTDNAVLVIRDLAAQQDVSEGGGVRIAADTQAGSLTVELVAEPVEGDQVVDTQGARIFLDSDAADLLGDASVDASVDDEGIVQFGFTEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7I2</accession>
    <name>F4F7I2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PfpI familyintracellular protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733081.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16585"/>
    <dbReference type="MEROPS" id="C56.001"/>
    <dbReference type="EnsemblBacteria" id="AEB44421">
        <property type="protein sequence ID" value="AEB44421"/>
        <property type="gene ID" value="VAB18032_16585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16585"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_4_11"/>
    <dbReference type="OMA" id="RDKLACA"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="174" mass="18854" checksum="91251769C068EC68" modified="2011-06-28" version="1">MSLSGKRVALLIEDEYQILEGWYPLLRLQEAGADVRVIGSGTKESYDSKEHYPMRADAGAPDVSAADFDAVIIPGGFAPDNMRLHPEMIDLVREAYEAGKLVAAICHGGWMLASAGATKGRRITGYLPIKTDVENAGGTWVDEPVVEDGNVITSRTPVDLPHFGRAIVEYLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Q0</accession>
    <name>F4F7Q0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734339.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22935"/>
    <dbReference type="EnsemblBacteria" id="AEB45687">
        <property type="protein sequence ID" value="AEB45687"/>
        <property type="gene ID" value="VAB18032_22935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22935"/>
    <dbReference type="eggNOG" id="COG1938">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055821_1_0_11"/>
    <dbReference type="OMA" id="IEPNMRW"/>
    <dbReference type="OrthoDB" id="834483at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="31869" checksum="2A78D068249465E0" modified="2011-06-28" version="1">MTEFDGLPVLRSPVAIAAFEGWNDAADASTAAVEHLEQVWQARPITELDPEDFYDFQVSRPTIAMSDGATRRVEWPTTRFTVASPSGTERDVVLIRGIEPSMRWRTFCEQVLEICHSLEVERVVLLGALLADVPYTRPLPISGSASDADAAKRYQLTPTRYDGPTGIVGVLHDACTRAEVDAVSFWVHVPHYANNPPCPKATLALLHRVEEVVDLPVPMADLAEEAAEWEQRVRSAAEQDAELGEYVRELEERVGDAGITPLTGDEIAQEFEKYLRRRGGSAGPTAGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7R5</accession>
    <name>F4F7R5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45702">
        <property type="protein sequence ID" value="AEB45702"/>
        <property type="gene ID" value="VAB18032_23010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23010"/>
    <dbReference type="eggNOG" id="COG3619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141547_0_0_11"/>
    <dbReference type="OMA" id="VGIQTGN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="23122" checksum="099344C42496D496" modified="2011-06-28" version="1">MFALMLGTGLAGVVDAFAFLRYKVFVGIQTGNVAFVGMGLAGHLPAWPSAVASLVAFGLGGLLGAGLRKFPSIGPLRPPGWELLALLALLVLWGLVDRSLDSGRDSLTERTILTALCAFPVGILGGLVTRTFGVQTATSFQTGTVLRTTRGLADWIFERGDTSGARRIAGLGLLCLASYAIGGYVGAASEQRPIVTYVIAWALIVVMFVLALLKRQSRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7X1</accession>
    <name>F4F7X1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C60, sortase A and B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735594.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29376"/>
    <dbReference type="EnsemblBacteria" id="AEB46946">
        <property type="protein sequence ID" value="AEB46946"/>
        <property type="gene ID" value="VAB18032_29376"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29376"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062592_5_0_11"/>
    <dbReference type="OMA" id="GPAIFLN"/>
    <dbReference type="OrthoDB" id="1771853at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="23231" checksum="E9447408A0FEDBBE" modified="2011-06-28" version="1">MTTRRADGRHGNPWRAVGAAVVVALAMVGSGLIGASLKGAETVRPPQPVARAGATPPADARFDDADLGSEHVAAALPRSAPTTISIPRIGVQAEIMSLGTNPDGTVQVPPLDQALLAGWYEPGPSPGEVGNAVIVGHVDSAAIGPAVFFSLGALQPGDTITVARTDGKPASFQVDSVVSHPKDAFPTEQVYGPNDRPGLRVITCGGQFDEVTGDYPDNVIVFASLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Y8</accession>
    <name>F4F7Y8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735611.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29461"/>
    <dbReference type="EnsemblBacteria" id="AEB46963">
        <property type="protein sequence ID" value="AEB46963"/>
        <property type="gene ID" value="VAB18032_29461"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29461"/>
    <dbReference type="eggNOG" id="COG2945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065354_0_0_11"/>
    <dbReference type="OMA" id="KHLWVGE"/>
    <dbReference type="OrthoDB" id="1090356at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="28951" checksum="71377BC8276852A5" modified="2011-06-28" version="1">MSAPIRASSILPGRREDIELHTADGLRLVGELALPVDRPPAATLVCLHPLPTHGGMMDSHVFRKAAWRLPALADLAVLRFNTRGTSSVRGTSEGTFDSAVGERYDVAAAIEYAEFHELPDIWLLGWSFGTDLALKYGCDPAVTGAILLSPPLRFSESADLTPWVESGKPLTALVPEFDDYLRPEQARERFAAIPQAEVVGVPGAKHLWVGDAETVLDEVVRRVNPAVPVPLPTTWDGPMETGDASAYADRTVAAFADTPVAGPPQRQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F879</accession>
    <name>F4F879_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731911.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10610"/>
    <dbReference type="EnsemblBacteria" id="AEB43240">
        <property type="protein sequence ID" value="AEB43240"/>
        <property type="gene ID" value="VAB18032_10610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10610"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_2_3_11"/>
    <dbReference type="OMA" id="VETMYLE"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="26615" checksum="965F0E98128E8BD9" modified="2011-06-28" version="1">MARRETALQAAHGRLRELIGSEFRSGDKLPNERDLAERLEVSRATVREVLGQLAAEGVVTRTWGIGTFVHDGAERVPVSISDVTALRDRITASGHRPTLQDAAVSRATCPPDCAKVLGLAPEAPVWRVDRLFAVDGVPAAWIRDHLPLSFDGRDLDPSGLVSIDLDMFEFLASATGMPVCRAEIELAAVLADEESTARLGVALGHPLITATQIGYGSNGAALFHGHFTVRTDVLTLKLSRGGDPQPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8D0</accession>
    <name>F4F8D0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44475">
        <property type="protein sequence ID" value="AEB44475"/>
        <property type="gene ID" value="VAB18032_16855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16855"/>
    <dbReference type="HOGENOM" id="CLU_2848628_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="6557" checksum="AB05B445AC86E906" modified="2011-06-28" version="1">MSLSGGCGGPFAANPFAFPLLGIPSFPHGAQLRGGGEQLTGSTDGRRGRRLGGMRVAVTTQQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8P8</accession>
    <name>F4F8P8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734443.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23465"/>
    <dbReference type="EnsemblBacteria" id="AEB45791">
        <property type="protein sequence ID" value="AEB45791"/>
        <property type="gene ID" value="VAB18032_23465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23465"/>
    <dbReference type="eggNOG" id="ENOG5032ZBB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166645_0_0_11"/>
    <dbReference type="OMA" id="MTEMSYL"/>
    <dbReference type="OrthoDB" id="1917445at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045423">
        <property type="entry name" value="DUF6510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20120">
        <property type="entry name" value="DUF6510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="94" mass="9795" checksum="87D4957DDD5E1572" modified="2011-06-28" version="1">MTTLPYVDGNMLDGPLGEVFAVDVSTATGRCAHCGTTGPVAALRVYSHAPGLVVRCPTCAEVMMRLVRAPDRAFLDLRGTALLQLPLPQVSAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Q0</accession>
    <name>F4F8Q0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase molybdopterin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734445.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23475"/>
    <dbReference type="EnsemblBacteria" id="AEB45793">
        <property type="protein sequence ID" value="AEB45793"/>
        <property type="gene ID" value="VAB18032_23475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23475"/>
    <dbReference type="eggNOG" id="COG2041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094953_0_0_11"/>
    <dbReference type="OMA" id="WESAGYH"/>
    <dbReference type="OrthoDB" id="1729032at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="36"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="199" mass="22367" checksum="1965D0E43B9FED52" modified="2011-06-28" version="1">MGIITPGFSGRPRSAAPDLPPGQYLTPDFPVLSAGPTPKVPRDTWEFVITTETGTEHRWSWDEMMALPQQTPTVDIHCVTRWSKLGTSWQGVSLDTLFEDVDTAADYALAHCYGGYTTNLPLDDLLDGQAWLVHTFDGEDLPAEHGGPARLLVPHLYFWKSAKWVRGIHLGHEDTPGFWETAGYHDYGDPWREQRYQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8U1</accession>
    <name>F4F8U1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_29751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735669.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29751"/>
    <dbReference type="EnsemblBacteria" id="AEB47021">
        <property type="protein sequence ID" value="AEB47021"/>
        <property type="gene ID" value="VAB18032_29751"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29751"/>
    <dbReference type="eggNOG" id="ENOG502ZZP3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114557_0_0_11"/>
    <dbReference type="OMA" id="MWIAEWP"/>
    <dbReference type="OrthoDB" id="1853589at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="197" mass="21165" checksum="6E730158F59565DD" modified="2011-06-28" version="1">MTIHHNTQRSIERPLERAEMPGSMLTTTAARALAVLRVATGLIFGWAFLDKMFGLGYSTPTERAWINGGSPTKGFLANVDVGPFQSIAHSIAGAWWANLLFMVGLAAIGVALLAGVGLRIAAASGSLMMALMWLADFPLARFNAAGDPTGSTNPVVDSHLMYAVVLVVLAAAYAGHTWGLGRRWAQLPFVQRNRWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8U6</accession>
    <name>F4F8U6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735674.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29776"/>
    <dbReference type="EnsemblBacteria" id="AEB47026">
        <property type="protein sequence ID" value="AEB47026"/>
        <property type="gene ID" value="VAB18032_29776"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29776"/>
    <dbReference type="eggNOG" id="COG2312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026490_1_0_11"/>
    <dbReference type="OMA" id="RYGCLTP"/>
    <dbReference type="OrthoDB" id="1068352at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="418" mass="46551" checksum="CC1DDA536DEEA674" modified="2011-06-28" version="1">MLVQRLGAPSDLDPLLERARDARVVMIGEATHGSHDYYRIREQLTRRLIAECGFDFVAVEGDWPDCDRVHRSVIGAAGGAVEPQVALERFERWPTWMWANAEVARFCSWLRAWNVERAEASRVGFHGLDVYSLWESMQAIFDYLGEEDPASLEAAQDAYRCFEPYGKRVEEYGMASRFVSARCEQEVVRLLARTRQLAAADGADAFSAWQNAEVVAGAERYYREMVAGGPGSWNVRDSHMADTLDRLLERYGPDARGVVWAHNTHIGDARATDMAADGMLNIGQLARERHGADEVVLIGFGSWRGSVIAAPRWGSPAEAMVVPPARVGSVEDLLHQLMPKRAVLVFGGPDQPGWVTEPLDHRAIGVVYDPSFESWGNYVPTRLGQRYDAFIWCDETTALHPLPALTTPGEMETYPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8V1</accession>
    <name>F4F8V1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735679.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29801"/>
    <dbReference type="EnsemblBacteria" id="AEB47031">
        <property type="protein sequence ID" value="AEB47031"/>
        <property type="gene ID" value="VAB18032_29801"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29801"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OMA" id="KHMVDAG"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="26086" checksum="C46A9575E07ECD35" modified="2011-06-28" version="1">MSEEPRVAIVTGAARGIGAATARRLAADGLAVAVVDIEESATKETVDAIGSAGGRALGVGADVSDRAQVEAAVERVVAELGAPTVLVNNAGVLRDNLLFKMTDADWDTVLGVHLRGAFLFSQAAQKHMVEAKWGRIVNLSSTSALGNRGQANYAAAKAGMQGFTKTLAIELGPFGVTVNAVAPGFIVTDMTAATAARMKIDFEAMQKHAEAEIPVRRVGRPEDVAHTISFLASEGASFVSGQVIYVAGGPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Y1</accession>
    <name>F4F8Y1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735709.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29951"/>
    <dbReference type="EnsemblBacteria" id="AEB47061">
        <property type="protein sequence ID" value="AEB47061"/>
        <property type="gene ID" value="VAB18032_29951"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29951"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="NHLRVIC"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="32756" checksum="60616236368C5988" modified="2011-06-28" version="1">MSDGQSRPTNDAQIVVSGLTKQYRNVLAVNNLSFTVAPGRVTGFLGPNGAGKTTTLRMLLNLVTPSAGTATIGGRRYPELTEPLRHVGAVLEASSAHKGRTGINHLRVICAAAGLPRQRADEALALVGLTPAAKRKFKGYSLGMKQRLGIAAAMLGDPRVLILDEPANGLDPEGIRWMRGFLKALAAEGRTVLVSSHLLSEMQLLADDVVIIAAGQLVRQGPVEQVIGSMAQSIRVRVRTPQAEALTTALADGPATVQTDEHGVLLIGGVDAPTVGRVALTAGVELHELTTERPDLERVFLELTAGKAGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Y3</accession>
    <name>F4F8Y3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Alpha-ketoglutarate decarboxylase</fullName>
            <ecNumber evidence="15">4.1.1.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">kgd</name>
        <name evidence="15" type="ordered locus">VAB18032_29961</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.71" evidence="15"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735711.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29961"/>
    <dbReference type="EnsemblBacteria" id="AEB47063">
        <property type="protein sequence ID" value="AEB47063"/>
        <property type="gene ID" value="VAB18032_29961"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29961"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_11"/>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="OrthoDB" id="29166at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="14">
        <location>
            <begin position="913"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB47063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1256" mass="138543" checksum="4B46E5E3A9CB7DB7" modified="2011-06-28" version="1">MSTQQTSQENPLAGFGPNEWVVEEMYQRYLADPSSVDPAWHDFFADYRPGPGAAKGDGEGAGRSTSAAEPARKESAPAKAATATRTEPAKAEPAVKTEPAKTESRTAPAKTAPVKAQPRTEPAKAPAKTAPAKTAPTATGPQTTPLRGVAAKIVQNMDASLAVPTATSVRAVPAKLLVDNRIVINNHLARGRGGKVSFTHLVGYALVRALVAHPEMNNSYAQVDGKPTMVSPEHVNLGIAIDLAKPDGSRNLVVPSIKGCEQMDFRQFWQAYEDVVRRARRNELTMDDYSGTTISLTNPGGIGTVHSMPRLMQGQSAIIGVGAMEYPAPYQGMSEATLAELAVSKVITLTSTYDHRIIQGAQSGEFLKVMHELLLGEHGFYDQIFTSLRIPYEPVRWMRDVAVDSEGQINKTARVHELIHSYRVRGHLMADTDPLEFKIRKHPDLDVLQHGLTLWDLDRTFPVNGFAGKQRMKLRSILGVLRDSYCRRVGIEYMHIQDPAERRWIQERVERKYEKPPADEQKHVLNRLNAAEAFETFLQTKYVGQKRFSLEGGESLIPLLGEVLESAAEGGLDEVVIGMAHRGRLNVLANIVGKPYEKIFSEFEGHLDPRSTQGSGDVKYHLGQSGKFTTPDGDHSVKVSVVANPSHLEAVDPVLEGIVRAKQDRIDLKLEGYTVLPLAVHGDAAFAGQGVVAETLNLSQLRGYRTGGTVHVVVNNQVGFTTAPEYSRSSLYSTDVARMIQAPIFHVNGDDPEAVVRVARLAFEYRQTFNKDVVIDMVCYRRRGHNEGDDPSMSNPQMYKIIDSKRSVRKLYTEELIGRGDITVEDAEELLRDYQSQLERVFKATRDAATTPRQLSRPPREDEPEPQVDTATDASVIKAIGEAHVNLPEGFTPHKRIQQLLDRRAKMAVEGNIDWGFGEIIAFGSLLHDGVTVRLAGQDSRRGTFVQRHASIVDAETGDDYLPLQSLTGDGERSRFFVHDSLLSEYAAMGFEYGYSVENLNALVCWEAQFGDFVNGAQSVIDEFISSGEVKWGQRSAVTLLLPHGHEGQGPDHTSGRPERFLQLCAEDNMRVAIPTTPANYFHLLRRQALSPKRKPLVVFTPKSLLRHKLCVSSVNDFTTGTFAPVLADPAAPAPEQVKRVLLCSGKVYYDLFQARQERGVTDTAIIRLEQLYPMPVEEIRAALAQYPNAEDFAWVQEEPANQGAWSFVALNLLEHLDGVRLRRISRPAAAAPAVGSAKMHEVEQVALLEAALPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F955</accession>
    <name>F4F955_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730757.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42083">
        <property type="protein sequence ID" value="AEB42083"/>
        <property type="gene ID" value="VAB18032_04785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04785"/>
    <dbReference type="eggNOG" id="ENOG5032DGB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313232_0_0_11"/>
    <dbReference type="OMA" id="GLPRMTH"/>
    <dbReference type="OrthoDB" id="2098810at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="20344" checksum="E88D44ECE63A3CE4" modified="2011-06-28" version="1">MQNHLVLLLPVAVVWWAAGYLAEGLPRMTHARELRRHAGWLLGLTLVGLSLTVALPIAGLTTAGATLADRAAAGLALAALPALVVALCTVRRVRRLRAGAGALAAAARTPAPHGLRAAAAHPLIGLPLQVTGLALLPALITASGAAEFFGPGITGPAVTIGVLGVGAIGVRHALRHNRLAERAMPQRSATSPSPARALHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F983</accession>
    <name>F4F983_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04925"/>
    <dbReference type="EnsemblBacteria" id="AEB42111">
        <property type="protein sequence ID" value="AEB42111"/>
        <property type="gene ID" value="VAB18032_04925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04925"/>
    <dbReference type="HOGENOM" id="CLU_210342_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="40" mass="4625" checksum="7BF37BCF52B8E877" modified="2011-06-28" version="1">MCAGCRVWWARLVPYPCWQVEWATSRQARASVARFLGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F985</accession>
    <name>F4F985_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04935"/>
    <dbReference type="EnsemblBacteria" id="AEB42113">
        <property type="protein sequence ID" value="AEB42113"/>
        <property type="gene ID" value="VAB18032_04935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04935"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_6_1_11"/>
    <dbReference type="OMA" id="TSPNFRH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="32380" checksum="2141FD8C60220593" modified="2011-06-28" version="1">MIMRIGIVILPDQRWSVARHRWQQVDEWGFDHAWTYDHLGWRDLVDGPWFDSMATLTAAATVTSRIRLGTLVASPNFRHPTAFARQVTALDDVSDGRVLLGLGAGGIGFDSAVLGGETLPPRQRVDRFGEFTELLDAILREDGTTWRGDWFAAVDARNNPGCVQQPRVPFVVAANGPRSMRLAARYGQGWVTIGNGGDDLDTWWAGVAETVARFDSVLAAQGRDPDALDRYLSLDAAPIFSLNSAQFFADQVGRAAELGFTDVITHWPRESSWYAGDEAVLADVATRLLPQLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9M8</accession>
    <name>F4F9M8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17520"/>
    <dbReference type="EnsemblBacteria" id="AEB44606">
        <property type="protein sequence ID" value="AEB44606"/>
        <property type="gene ID" value="VAB18032_17520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17520"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023506_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="520" mass="57200" checksum="5BD94002CB4AC02A" modified="2011-06-28" version="1">MTQTYVNPINLPGMAVRHIVGTMPPTDANVANTSQIPASLNLPTWTAASGRTLSSRSSVGFTRISENSARTGADWSAVNVDGTIYLYASGAMQNAPNNNRTVWSTTDYLTWTPHEMNLGLVAPTVVQVGDTFYMAGNNTPVYRADSPTGPWTSMGSFLRPNGQVLSVGDVQFFLDTDGRLYLTYNIGSPIMGAELDPNNPRQLISEPVVLWTFDPRQEWQHIGDNKATYTHGYVEGSQLFKLGDTYYLQVASGGTEFTTYATGVMTSDRPLSGFTETQRNPIGAGNNHPSSVYPNAGHGSFVVDNAGNLVFFYTYVIAYEEFFERRLGMDVCTVIPNGPQKGAIDCELSNTPQLAPGRKISGRDDVGLYNVATNSQAYWSSSYAPGRNPYYGSDRSLSTWWEPADTDSAPTYIRGFGTVFHISAAQIQWKELGRTFTKDNAVQYTLEYKDIPTNTWRTLVDRSTNTTAYTADYVTFDRVLTNAVRLKILGTTENVKVGVHELNVFGENYHLVASKGMITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9T6</accession>
    <name>F4F9T6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, LuxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734514.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23820"/>
    <dbReference type="EnsemblBacteria" id="AEB45862">
        <property type="protein sequence ID" value="AEB45862"/>
        <property type="gene ID" value="VAB18032_23820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23820"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_0_2_11"/>
    <dbReference type="OMA" id="ARLAHHW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="890"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="956" mass="102925" checksum="6597918C3027AD56" modified="2011-06-28" version="1">MASDVDSTPLVGRADLVATARAALLDDVAPGSTAAVFLTGESGVGKTRLLRELGQRLGDAGALVLTGSCLDIGDASPLHPLRQALRRLDVDLPPAAAASVRALLAMFAEDAASPDGAGALLERVARGLSVIAGGRPVVLVLDDLQWVDRTTRQLLLYLLAGLGDLQLSVLAAVRSESLQGAHPLRRVLTELRRLRSVQVLDLAPLDRAAAEQLAAAVVGRPLPPEAVERLCQRSGGNPFVVEELARDLRDGRDGLSDTLREVFLARVDALPQPAHRVVHAVAAGVEPVDHWLLAQVVGLPEQDLLDAIRATVAHRLVVSSHDGYRLRHRLVAEVLEDELLPAERALLHRRYAEALTAAPGELHQARLAHHWRLAGEPQRALPAAVAAAQEAERLYGYAEAHRHWSVAVELAEGLPDAERATLLRHAAEAAHHCGEYARALALLEKLAAIDADQTACELHIRRARYLAAAGRSALAEAEYQRALDAADCSPRQRATAAAHLAELLLQLGRYADAGQWAKEALSLAEQAEDATTEVVLASMALGFSEAYRQDPDAGLAVLRRALATAERAGRPEDVALAYLHLAELLTGPLNRMEEGVVVARRGAERVAELGLGRSYETRLLAIATNGLFRVGQWAEAEKVVAAALRHRPSGTDAVELLLARCRLSVGYGDIEAADRDLDAVATMLAGGGARHVIPLLTLRAGLAMWQGRHDVARHAVQRGLTETRSDDLVIVAVLVWHGLRAEAEAKASRTPVDDNAVRRLRQIVDRVAEKSVRAAQPVRDVVDGYLALCAAEVSRLDVTDPDLWARAAAEWDHRNHPYPAAYSRLRQAEALLARRRRTATAGKLLRQAYQTTQGLGAVPLTEEIRTLAGRARVTLEDAGPLGAREPDGDGGAELAALTAREREVLAAVAEGLTNREIGQRLYISERTIGVHVSHIFDKLQVRTRVQASAIFLRSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA24</accession>
    <name>F4FA24_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maltose o-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_00255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00255"/>
    <dbReference type="EnsemblBacteria" id="AEB47135">
        <property type="protein sequence ID" value="AEB47135"/>
        <property type="gene ID" value="VAB18032_00255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00255"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_0_11"/>
    <dbReference type="OMA" id="DCQIGPN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="178" mass="19157" checksum="EF1B2C39506834D8" modified="2011-06-28" version="1">MLAGEPYLADDPELIADHLRALRLLEQFNSGPVDQREARLAVLRELLGDLGEETWIRPPFHCDYGYNIRIGPRSFVNFQSVFLDVAPITLGADVQVGPNVQLLTPTHPVEPEQRRAKWEAAQPITIGDNAWLGGGAIVLAGVTVGDNTVVGAGAVVTRDLPANVVAVGNPARPVRQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA27</accession>
    <name>F4FA27_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_00270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735784.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00270"/>
    <dbReference type="EnsemblBacteria" id="AEB47138">
        <property type="protein sequence ID" value="AEB47138"/>
        <property type="gene ID" value="VAB18032_00270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00270"/>
    <dbReference type="eggNOG" id="COG2968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1287630_0_0_11"/>
    <dbReference type="OMA" id="GPWWSLR"/>
    <dbReference type="OrthoDB" id="1821429at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="23495" checksum="239D68B78C920256" modified="2011-06-28" version="1">MVDGPVVTVRGEAYREVDPEVAQFTVTALARDRDREVVLTRLAERAAAIRVLLDAAESSIHRRETGDLRVRPETRRSGERVVAWHGSVVTTVTVTDFTALGEVMLRLADQDQVEVAGPWWSLRPDSPTYRAARHDALTDAVQRAREYAEALGAQVTDLIELADEGGGAQPQMMRMAFDAETTAGGPPQLDFDPQPQQVHAAVRARFAITRPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA39</accession>
    <name>F4FA39_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00330"/>
    <dbReference type="EnsemblBacteria" id="AEB47150">
        <property type="protein sequence ID" value="AEB47150"/>
        <property type="gene ID" value="VAB18032_00330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00330"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="CHFPEDP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="36112" checksum="0F5F94CFF489FA5A" modified="2011-06-28" version="1">MPGCRGDAMTAGEALLRVRGLTRHFPVRGGLLRAVDGLDFEVRAGETLGLVGESGCGKSTTARLLVRLLEPTGGRIEFAGQDISRAGRRALRPLRPQMQIIFQDPYASLNPRHTAGQIIAMPLRVNRITPPGGVRARVRELMELVGLDPEHDNRYPHEFSGGQRQRVGIARALATGPRLVVADEPVSALDVSIQAQVVNLLRRLQRELGLAFVLISHDLAVVRHFCQRIAVMYLGRIVEIGDRDDICRRPQHPYTRALLSAVPDVARRDRAGRIRLAGDVPSPVDPPSGCRFRTRCPSARERCAVQEPALIRRDGGNRATACHFPAGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAJ5</accession>
    <name>F4FAJ5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732092.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11540"/>
    <dbReference type="EnsemblBacteria" id="AEB43422">
        <property type="protein sequence ID" value="AEB43422"/>
        <property type="gene ID" value="VAB18032_11540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11540"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066396_0_0_11"/>
    <dbReference type="OMA" id="WDLAYAV"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="29685" checksum="1BD3B0D5C4328714" modified="2011-06-28" version="1">MTSQEIPLHGGNVSTVVRVGDTVRRNAGPWTPSVHALLRHLEYVGFTGAPRALGMDERNREVLSYLEGECGEYPLAPHWVTDEALVTVATMLRMFHDAQYGFAPPANAVWRSFGPPPPDTEVICHHDAAPHNVIWRPDGTLGLIDFDLASPGARIYDVAYAAWTWVPIFSDRDSITLGWKRPDRPRRLRLFADAYGLIPRDRHRLIGTIRKRIIDHVEGIRRMAAAGEPAFVRIVHKGHLRRPMRDLRLLDYERRALESALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAN6</accession>
    <name>F4FAN6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_17745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733306.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17745"/>
    <dbReference type="EnsemblBacteria" id="AEB44651">
        <property type="protein sequence ID" value="AEB44651"/>
        <property type="gene ID" value="VAB18032_17745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17745"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_11"/>
    <dbReference type="OMA" id="FITNGTW"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="382" mass="40051" checksum="36DC5B71B986244A" modified="2011-06-28" version="1">MDLHLSAEQVAVRELAADFVNREVVPHAATWDRREAVDPGIVGKLGDVGFLGLTIDEEYGGSGGDHLAYCLVLEELGRGDSAVRGIVSVSLGLVAKSIATHGTREQREQWLPALCSGTALGCFALTEPDSGSDAAALTTRAVRDGDDWLLTGRKTFITNGTTADVALLFARTGGPGHRGITAFLVPTDSPGLSRSEIKGKLGLRGQATAELVLDGVRVPDTARLGECGAGFRLALGTLAKGRMSVAAGCVGIAQGCLNAAVDYAGARTQFGKPIAGHQLVQQLLARIAVDTAAARLLVWQVADLIDRGQPYATEASMAKLFASEAAVRAANDAIQVFGGYGYIDEYPVGKYLRDARVTTLYEGTSQIQQLLIGRALTGVNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAX2</accession>
    <name>F4FAX2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_24185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24185"/>
    <dbReference type="EnsemblBacteria" id="AEB45935">
        <property type="protein sequence ID" value="AEB45935"/>
        <property type="gene ID" value="VAB18032_24185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24185"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_11"/>
    <dbReference type="OMA" id="IWQTAGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="34716" checksum="CE7B3A4612766A3B" modified="2011-06-28" version="1">MPRAARRTWRRALRRDWQLYSLAILPLLFFLIFRYLPMLGNVIAFRRFQPGGNIFGEYWVGLRYFKMFLNDPTFWNVFTNTLALGALTLLFCFPLPIVLALLLNEVRAGRLKRFVQSVSYLPHFLSIVIVAAMVMQLLSMDGTINQLVHAGGGEAIPFLQRPEWFRTIYVSSEVWQTVGWGTILYLAALTTIDDDLYEAARIDGANRWRQTWHVTLPGIRPTMVTLLILNIGTFMAVGFEKILLLYNPLTYPTADVISTYLFRVGFTSSNFSYAAAIGLFEAVIGLILVLSANLIARRTVGTSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBG5</accession>
    <name>F4FBG5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05675"/>
    <dbReference type="EnsemblBacteria" id="AEB42261">
        <property type="protein sequence ID" value="AEB42261"/>
        <property type="gene ID" value="VAB18032_05675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05675"/>
    <dbReference type="eggNOG" id="ENOG5032DXS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210342_0_0_11"/>
    <dbReference type="OMA" id="WWSRLAP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="59" mass="6659" checksum="C4BB9ECC95EA3D66" modified="2011-06-28" version="1">MKNDQEHAILAVHGRGLDGMCAGCRAWWSRLAPYPCWQVEWATSRQARTSVARFLGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBH6</accession>
    <name>F4FBH6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ordered locus">VAB18032_11620</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732108.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11620"/>
    <dbReference type="EnsemblBacteria" id="AEB43438">
        <property type="protein sequence ID" value="AEB43438"/>
        <property type="gene ID" value="VAB18032_11620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11620"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_1_0_11"/>
    <dbReference type="OMA" id="YPTKLHL"/>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="31"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB43438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="270" mass="28757" checksum="6CE9A0C3E16DCB8A" modified="2011-06-28" version="1">MLTPPRTVVRREAGLYALERALQRRGFRYVAGADEAGRGACAGPLVAAAAVLPEGRRGEIDGLADSKLLTPASRERVYDEVVARALAYAVVVIPAEEVDARGLHVCNLAAMRRALASLTVRPEYVLTDGFGVDGLDVPGLAVWKGDRVAACVAAASVLAKVTRDRIMVDLDAEHPGYGFAEHKGYITADHTAALREHGPCREHRFSYVNVAAVSGLDGRPPRSRRPLGASWDEPMERSGFAGGTVGVALGEQRQRPAPVGEDVVMEGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBJ7</accession>
    <name>F4FBJ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732128.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11725"/>
    <dbReference type="EnsemblBacteria" id="AEB43459">
        <property type="protein sequence ID" value="AEB43459"/>
        <property type="gene ID" value="VAB18032_11725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11725"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_11"/>
    <dbReference type="OMA" id="WHLHPDS"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="180" mass="20098" checksum="C37053659B5AD459" modified="2011-06-28" version="1">MTVASTDRLVLREWTDSPDDLARIFDIYSREDVMRWLGGGAGRLLDPDQAAERLATWRQRYAPYDGRYGLWAIEVRDTRTVAGSVLLKPLPGADGHTPTDDIEVGWHLHPDSWGHGYATEAARAVLAREFAAGNRQVYAVVMPGNERSMAVCRRLGMSSLGRRTDWYGGTEVETFVLTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBM6</accession>
    <name>F4FBM6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin reductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11870"/>
    <dbReference type="EnsemblBacteria" id="AEB43488">
        <property type="protein sequence ID" value="AEB43488"/>
        <property type="gene ID" value="VAB18032_11870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11870"/>
    <dbReference type="eggNOG" id="ENOG5032JS9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151362_3_0_11"/>
    <dbReference type="OMA" id="PLWRCRN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="76" mass="9128" checksum="57D34B61B156F753" modified="2011-06-28" version="1">MAMRPLWRCRNCGAEWPCQPARLALLMEYRRDRLGLLLYLGGLMVQARDQLAQLNPEHTPDLYDRFLGWARRRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBT8</accession>
    <name>F4FBT8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733393.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18180"/>
    <dbReference type="EnsemblBacteria" id="AEB44738">
        <property type="protein sequence ID" value="AEB44738"/>
        <property type="gene ID" value="VAB18032_18180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18180"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129810_0_0_11"/>
    <dbReference type="OMA" id="GMRHRIV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016672">
        <property type="entry name" value="Polyketide_Synth_CurC_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016602">
        <property type="entry name" value="CurC_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="142" mass="15184" checksum="5DA24A529FC99796" modified="2011-06-28" version="1">MAEKHPSTVARAAVPANRRRGGDIRVLLSPRTVGATAGFMGSLTLAPGEYVSEHYHPYSEEYLYVVAGVLTMTIDGHTVEVGPDHAVLVPIGARHRAENRGGALVRAVYHLGPLAPRPDLGHVDTEEPPHRAESQIVVGDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBY3</accession>
    <name>F4FBY3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Wyosine base formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733438.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18405"/>
    <dbReference type="EnsemblBacteria" id="AEB44783">
        <property type="protein sequence ID" value="AEB44783"/>
        <property type="gene ID" value="VAB18032_18405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18405"/>
    <dbReference type="eggNOG" id="ENOG502Z7S3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067335_0_0_11"/>
    <dbReference type="OMA" id="ETFAHGQ"/>
    <dbReference type="OrthoDB" id="1410521at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017518">
        <property type="entry name" value="CHP03084"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03084">
        <property type="entry name" value="TIGR03084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Wyosine_form" evidence="1">
        <location>
            <begin position="186"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="268" mass="28870" checksum="943D1130AE41CAFA" modified="2011-06-28" version="1">MTQAPDVIADLTAESEALDAVVAKLSDEQWETGTPAHGWAVRHQIAHLAATFRLAGLAAAQPAAFQQMTSRLSDDFDANVAAAMADFVVEPPAVLLSRWRSERATAEKALAAVPPGQMVPWLVRPLPAPVLAAAGMMEVFAHGRDVLDALGVRPSYTDRLGHLVGFAVRTWDFGYLARGLTAPDVQFRFEITAPSGALWAFGPADADQRITGPAEDFCLLVTRRRHRDDLAVRAVGSDAEHWLDIAQAYRGPAGPGRRPGQFSQTDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC53</accession>
    <name>F4FC53_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin resistance ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24765"/>
    <dbReference type="EnsemblBacteria" id="AEB46051">
        <property type="protein sequence ID" value="AEB46051"/>
        <property type="gene ID" value="VAB18032_24765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24765"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="RESIGYM"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="37025" checksum="D29C02BB5E1A40B1" modified="2011-06-28" version="1">MSVTTRNQTEPPGARAEVGTGIEAVDLVKSYAPPAARGRGRNAPPPVPALRGVSFAAPQGTILGLLGPNGAGKTTAVKILTTLSTPDSGTALVAGIDVAKNPTAVRRVIGYVPQKPSFDPNLTGRENLILQARIYGANRADAGRDADAILARFGLSEAAGRITRKWSGGMQRKLDVAMALIHSPKVLFLDEPTTGLDPEARSELWTAIADLTRAGDLTVLLTTHYLEEADRLADHLVIVDRGTVVASGSPEQLKDGLAGDTIHAGVASPDLVESARAALLGVDGIDEVTVDGTDLYARAASASRVLAGVVAAFEAAGVPLATVTAARPSLEQVYLHHAGRSYRSAQEDRREEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCG3</accession>
    <name>F4FCG3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver modulated serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730963.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05820"/>
    <dbReference type="EnsemblBacteria" id="AEB42290">
        <property type="protein sequence ID" value="AEB42290"/>
        <property type="gene ID" value="VAB18032_05820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05820"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_7_11"/>
    <dbReference type="OMA" id="CCYPARE"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="511" mass="55331" checksum="932A301B09ED52B4" modified="2011-06-28" version="1">MEIPPTVLVVDDSRTKRYLLVNWLTRAGFTVIEAESGSEALRQVEVDPVDLVVLDVRLPDLSGFEVCERIKSTHPALPVIHVSAHAIDTTDRAQGLTRGADAYLAEPIDPEELIATAHAVLRYYQARQRAELLAERLAGLADTTVAVHAAPNFDRLLELAAAGTAEIFKSPAAVIAETFDGECLAGVCAGPGAESRVVPWVVDDSDTPVGATVRVEEPADWALVQWPPDDTVTVAAGRLRDDRAPLYVVVPTATQTAQTPVLRQLAQAVASAVEVQRSFDEEHRIAVTLQRSLLPQRIPQIAGLDLAVRYEPASARTEIGGDFYELVMLDGHLLLAIGDVAGHSLHAATVMAELRHALRAYAVEGHQPGEILHRVNELMRTLLPTELATICVLLLDPATGQVRLASAGHLPPLISMDGKTEYVHHSAPLLGVRAPRPADLEFVLPPGATIVFYTDGLIERRDVNIDEGLKSLAASAVRVDADLDRFCQRLLDELAPDEIQDDVAVVALRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCL1</accession>
    <name>F4FCL1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetate-CoA oxygenase, paaj subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731011.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06070"/>
    <dbReference type="EnsemblBacteria" id="AEB42338">
        <property type="protein sequence ID" value="AEB42338"/>
        <property type="gene ID" value="VAB18032_06070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06070"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082133_0_0_11"/>
    <dbReference type="OMA" id="EPFDHFK"/>
    <dbReference type="OrthoDB" id="1668114at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011883">
        <property type="entry name" value="PA_CoA_Oase4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02159">
        <property type="entry name" value="PA_CoA_Oxy4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="158" mass="16770" checksum="7EBAA0A2074F4749" modified="2011-06-28" version="1">MNAAHEAVAAVVDPEIRVITIADLGILRSVEVEPATGRVVVTITPTYTGCPAMDVIRADIRRALAVAGHPDAEVRTVHSPAWSTDWITDAGRAKLAAAGIAPPAPVRRDGVVPLTLAVRCPRCGSPETEQLSRFGSTACKALWRCRACSEPFDHVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCV9</accession>
    <name>F4FCV9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_18445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733446.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18445"/>
    <dbReference type="EnsemblBacteria" id="AEB44791">
        <property type="protein sequence ID" value="AEB44791"/>
        <property type="gene ID" value="VAB18032_18445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18445"/>
    <dbReference type="eggNOG" id="COG4658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062026_0_0_11"/>
    <dbReference type="OMA" id="VEFLFPA"/>
    <dbReference type="OrthoDB" id="1654433at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB44791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="334" mass="36030" checksum="46B27734AEB8F079" modified="2011-06-28" version="1">MADTKTSPVRHDAKTTTALRRFAISITIFNIVGYVYLGFEQPWLWPFIALATGYTVEIVLEVIGARAEGRAPRFLGAGKRGFVEFLFPAHITSLAVNMLTYVNDRVWVMMFGVTVAIAAKWILRAPVRGRLRHYMNPSNFGIAMILILFPWASIAPPYHFTEHTPALGDWLVPAIILTAGTMLNAKLTGRMFLIMGWLSAFVLQAVIRGLVLDVSILGALGMMTSVAFVLFTNYMITDPGTSPSRPASQIAFGAGVASLYGLITGMGIAYGLFFATAAVCLIRGMFLWALHISNKAREQREAAAAAAAPTDGVPVPATDALAAGPNSHKEAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCW9</accession>
    <name>F4FCW9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18495"/>
    <dbReference type="EnsemblBacteria" id="AEB44801">
        <property type="protein sequence ID" value="AEB44801"/>
        <property type="gene ID" value="VAB18032_18495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18495"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681432_0_0_11"/>
    <dbReference type="OrthoDB" id="1368479at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="PTHR31048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="SSF49870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="1">
        <location>
            <begin position="275"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="42620" checksum="59DA68225B74557F" modified="2011-06-28" version="1">MTVSTGSFPGGKARLGGRIALLTILTLALGLVVVMSSRSDAVVGERVTFVNSTGETLWIGAGESADGSRPITGLPVLRPGASATIVIPDDGRPGHWRGRFFARQRCSGEPGSTFRCLVGDCGVHPDRCERGAEPVSLAEFNFDQHNSGAPWYNVSYVDALSLTITIETPGGPPAPVAGTCVRWDCSGGQLLAACPEAHAVIDPQRGDRINCVNPERDSESTYTAALRPFGPRAYLWSTHDRVPGNETVLSCPGCADFVVTFRGGGAPVRRTVEQPASTFALRGYQGKCIDVPGGISADGAGLQLWRCNDSPAQRFSHGPNGSLMALDKCMDVAWASRDNGAKVQLAHCNGGPAQVWVVEAGMLRNPHSGRCVDVRGGNTADGAALQTWECAPGRANQTWQPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD50</accession>
    <name>F4FD50_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734732.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24910"/>
    <dbReference type="EnsemblBacteria" id="AEB46080">
        <property type="protein sequence ID" value="AEB46080"/>
        <property type="gene ID" value="VAB18032_24910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24910"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244146_0_0_11"/>
    <dbReference type="OMA" id="LMAWFAT"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="470"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1515"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1498"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1499"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1604" mass="171234" checksum="8F73C4331ED6EB33" modified="2011-06-28" version="1">MIPMSYAQRRLWFLNRLEGPSSTYNAPVVLALSGVPDPEVLAAALTDVVDRHEVLRTAFAMADGEPVQRVLPTATVAVPVQRCAPQEVDAEVRRFCAGTFDLAEQGPLRVRLFVARPDESVLVLLLHHIATDGASIAPLLRDLSTAYRARLAGAAPDWEPLPVQYADYTLWQRELLGQVDDPDSELSRSLAWWRENLAGSPSALPLPFDRPRATGASGRGGTVTGHLDADTHRRLVDLARSQRASTFMTMQAALAAALTRIGAGTDVPIGAPVAGRSDEALHDLVGFFANSVVLRTDVAGDPTFVDLLARVRDADLAVYAHEEVPFDLVVEQLNPVRAPGQHPFFQVMLTVGAHTPTDLRLGDLPARTLPVDLEVAKFDLTVYCTELRDSDSTPTGVQVEFQYPVDLFDRATVESMLAVYLRLLRAVALAPTSTVGALQVVTDTEGAGFAERIARAAPAGVRRPDLPDDGPASLREEILCGLFADALGVDRIGRNDSFFRRGGHSLLAIKLVNRVRAVLGVEVGLRDFFVDPTVAGLDRRIGTLAGTGARPPLAPAVRPDLLPLSYAQRRLWFLDEMGGASRMYNIPVVLRLHRPVQASALTEAVRDVADRHEVLRTVYAVIDGEPCQVVLDRAQPEVTVLDVPVADLPGVIDAVTGHVFDLGTQIPFRVWLLRLSDGGQLLVVLVHHIAGDGWSTGPLLRDLAVAYEARLAGTAPGWEPLPVQYADYTLWQRDLLGGAGNPDSALARQLGFWRTTLAGAPQVLDLPADRPRPAQASHRGDVVPFGMDADLHRAVLRTARDSGTTVFMVLQAAFAALLSRIGSGTDIPIGTVVAGRTDEALDNLVGFFVNTLVLRTDVSGDPTFTELLARVRDTDLAAYDNQDLPFERLVEELNPNRSTAHHPLVQVTLVLQNTGSVQNGAAGPSALAGTEVPFDTGTAKFDLTLGVREEFDGGTPKGLKGALEYAADLFDPATAQLLADRFVQLLRAVTADPGTRIDDLDVLTPAERRRYGPAAEHGCRAESVGLADLVARHAADNPQAVAVVSGSDRIRYAELDADADRLAAHLAARGVRRGDTVGVLLEAGPTLAVAVLAALRAGATYLPLDPAARDDRLAAHIRTVVLAAVVTTSDQATRLAGLRVGRTVLTDVDGWRERPAAPPPGPRDPGDGAVVLVVDDADGPRAVRYPHRALVGAARRAGLDTDAAQVWLGWAAPAGGEFMMPLWSALSTGATCVLPAPAPPSAARLARLVAEQGVTSLTVTAELFALLVEEHPQVLTRLRQILVTGRTAAAHLALARDRHPTLRLVHGYGGVEGGWWALGRVVDTPPVGPDVPVAQDGLRCHVLDDRLRPVPAGVRGELFLCGPGLADGYPDRPGATAARFVADAGGGRMFATGTSASWSAEGGLRVHGPVAAPTCNGVPVDPQRVSTALISHPSVRWAVVSVRADADGGEQLVAHVVPTTSSVDVAQVRRHVAQLLPEHLVPARVVVLTTVPLTGDGRLDHRGLPDPEDTGAGKTARDPREEVLRDIFSELLGGRPVGLDDNFFRIGGHSLLAVRLVNRIRSTLSVEVTIRDVFQAPTVAALVERLTATVTPARPTLRRRAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDJ7</accession>
    <name>F4FDJ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily mfs_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_06180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731033.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06180"/>
    <dbReference type="EnsemblBacteria" id="AEB42360">
        <property type="protein sequence ID" value="AEB42360"/>
        <property type="gene ID" value="VAB18032_06180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06180"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058822_0_0_11"/>
    <dbReference type="OMA" id="AGYPAMW"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="400" mass="39556" checksum="6932E52886F63B19" modified="2011-06-28" version="1">MPDTAPLPDTTATTRPVRASAVAVVVTIACVLPVFLVGGLAVQMREDLHFSPAGLGLVVAVYFGVGALASVPSGALVERWGGAVVARAGILVSASCLLAVAVLARSYPVLLALLAVSGTANALGQLSSNVLLARHVPARRQGLSFGIKQAAIPVSTLLAGAAVPTFALTVGWRWAFVAAAGAALATLPAVPAQPAQPARRSVRGAGRGTFPLVVVGIAATLAAGAAGALGTFVVDAAVDRGLEPALAGLTLTLGSAACVTARVGLGWLADRRSGGHVTIIAGNLVVGAIGLALLAMAGSAPLVVGVLLGFALGWSWPGLMNFAVVQLHPQAPGAATSITQTGVYAGGALGPLTLGPLAAAAGYPTMWLTAAVAMLAAAALMLTATRLLSAQRHPVATRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDQ6</accession>
    <name>F4FDQ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intracellular protease, pfpi family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731092.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06475"/>
    <dbReference type="MEROPS" id="C56.001"/>
    <dbReference type="EnsemblBacteria" id="AEB42419">
        <property type="protein sequence ID" value="AEB42419"/>
        <property type="gene ID" value="VAB18032_06475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06475"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_4_11"/>
    <dbReference type="OMA" id="IGKYGVP"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="19764" checksum="3E91504FF93D24BB" modified="2011-06-28" version="1">MAATLQGKRVAFLATDGVEEVEYVQPRQAVEQAGATAELVSIKPGKITSFQHLDPSQTYEVDVSAADADPDRYDALVLPGGVANPDFLRTDPDAVRFVRSFFDAGKPVGVICHGPWTLVEADVVRGRRITSWPSLRTDLVNAGANWVDEQVVTDNGLVSSRKPDDLPAFCAKIVEEFAEGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDS7</accession>
    <name>F4FDS7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein arsr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732277.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12470"/>
    <dbReference type="EnsemblBacteria" id="AEB43608">
        <property type="protein sequence ID" value="AEB43608"/>
        <property type="gene ID" value="VAB18032_12470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12470"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_2_11"/>
    <dbReference type="OMA" id="RGRDAQW"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13522" checksum="66D52D12779D0378" modified="2011-06-28" version="1">MHIDLDATFAALADPTRRAILARLATGEATVTELAAPFAMSQPAISKHLRVLERAGLISRSRSAQRRPCRLNAGPLQEATAWLAAYRDHWAESYQRLDNLLDELRATEETAAGEPAEAEGGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDU7</accession>
    <name>F4FDU7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigA</name>
        <name evidence="9" type="ordered locus">VAB18032_12570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732297.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12570"/>
    <dbReference type="EnsemblBacteria" id="AEB43628">
        <property type="protein sequence ID" value="AEB43628"/>
        <property type="gene ID" value="VAB18032_12570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12570"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_2_2_11"/>
    <dbReference type="OMA" id="MAWICRD"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="302"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="381"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="470"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="535" mass="58098" checksum="54BF597FF1D0F7A0" modified="2011-06-28" version="1">MTEPRQTGADVRSLTDTLIAHAQSAGGQLTSAQLARTVESAEVTPAQAKKILRALSEAGVTVVVDGSASTRRRVAAARSATPASRATTAKTTKKAAPPAPKQAPAAEEATAPAPRKATSRKTTGTTAEVAAKAAVPAKKSTRATKATVAAASAAKPTKAAGKAKGEGAEGDVDPEELAAEIEDVVVEEPAELAQAAEADAASSASDNDFEWDDEESEALKQARRDAELTASADSVRAYLKQIGKVPLLNAEQEVELAKRIEAGLYAAERLRAAEEGEEKLARDMQRDLLWISRDGERAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFSLLQDQLQQVLQTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE39</accession>
    <name>F4FE39_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733563.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19030"/>
    <dbReference type="EnsemblBacteria" id="AEB44908">
        <property type="protein sequence ID" value="AEB44908"/>
        <property type="gene ID" value="VAB18032_19030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19030"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1149939_0_0_11"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="129"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="232" mass="24965" checksum="3D63CCF5F96537E8" modified="2011-06-28" version="1">MSVLPVLDAAPGCCPPLAVQPLTPPVAGELAPLFKALGDPVRLRLLSLIASTTEVCVCELTEAFEVTGATISHHLRVLRESGLVDSERRGTWVYYWVRREALDLLGNLLTGSADTPSRVAPVQVRPETDQQPLISANPDVVRLLADPLRARIVQILADGPATTSHLVADTAAKQPNVSGHLKLLREAGVVTAEPRGRFTYYRLVPDVLQGAALHLADLAAQARIHAENFRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEP0</accession>
    <name>F4FEP0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731107.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42434">
        <property type="protein sequence ID" value="AEB42434"/>
        <property type="gene ID" value="VAB18032_06550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06550"/>
    <dbReference type="eggNOG" id="ENOG5031W03">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2618091_0_0_11"/>
    <dbReference type="OMA" id="TMVAYVA"/>
    <dbReference type="OrthoDB" id="2219425at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="8470" checksum="6160D9EB56F337BA" modified="2011-06-28" version="1">MSVDQELILERDKAESAEPVSTATVVAYAVVGALLFGWFLFGWLVLQQGFIDSVGEAAGTGFALLLIVAIVGSVRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEQ8</accession>
    <name>F4FEQ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_06640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB42452">
        <property type="protein sequence ID" value="AEB42452"/>
        <property type="gene ID" value="VAB18032_06640"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_0_11"/>
    <dbReference type="OMA" id="GFQFTAV"/>
    <dbReference type="OrthoDB" id="460405at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="TM_effector"/>
    </dbReference>
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        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="233"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="432" mass="44982" checksum="E2AD4791C4A3A276" modified="2011-06-28" version="1">MTSKDTSRQREQRRWAIDLRPLRVPAYRRLWVGNAIAMFGFQFTAVAVPVEMYALTEDSLWVGLLGVAAFVPLLVFGLWGGAVADALDRRRVLLGGSVLLWVSVLGLLAQALLDVGSPMLLLALVALSSVSFAIASPARAALVGRLVPVELVPAATTLNFTTAMATSVLGPLAAGLILAVFELGIALPVAYGLDATLLVALVWAALRLPAMPPEPDPDGGPRQAGLRSIVDGVRYLAGAPVLLLSFAIDLIAMVFAFPRALFPEVATERFGGGAAVGWLYSSIAIGSLLAGLLSGWIGRVRRQGLVLVLAVVGWGVAVALAGLARQLWLVVALLVLAGAADLVSSVVRQSMLIVYAPDRMRGRLQGVNTVVVAGGPRLGDLRAGAMAAGFGSGVAWVGGGLAAAVLAVLLAVAFPALTRYRAAIQTGDRRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF47</accession>
    <name>F4FF47_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19250"/>
    <dbReference type="EnsemblBacteria" id="AEB44952">
        <property type="protein sequence ID" value="AEB44952"/>
        <property type="gene ID" value="VAB18032_19250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19250"/>
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    </dbReference>
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    <dbReference type="OMA" id="GTNSCAN"/>
    <dbReference type="OrthoDB" id="1757059at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005347160" evidence="1">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="27857" checksum="145E6C35D4D3EC6B" modified="2011-06-28" version="1">MRLSISALALVAALALAGAPDPGPQVGVDRAEAKPGEQVLVRLTGWPGGTVRIELCGAGTPTRCAVDSSAQIHLPAGGAGGTPLTVVAPPGGCPCQVRVTTLDNSLSATAPLVVTGAPAPVDDTVRQAATRPPTVLAAHLERADGWTAHFGAPARRTLVLRLRNEQPAPVNVAWSFSVGRGPDPTGFVTPPEPDEFAAGEEREVRVPVTLPAFAVGTYQIHGDIVTAGATSRVTASTDHQPWGLAGMLGFVLTALAVVRPLKGASAGWRNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFC1</accession>
    <name>F4FFC1_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase sdr</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">VAB18032_25625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AEB46223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25625"/>
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        <property type="protein sequence ID" value="AEB46223"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="PGWGLYC"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="284" mass="29845" checksum="147DFCF97D8C7589" modified="2011-06-28" version="1">MASATRPVTWFVTGASQGLGLELVRQLLGRGDNVAATTRSTERLLTALGPAAGERLLPLGVDLGDEQAVNVAVRATTDRFGGIDVVVNNAGYGFLGAVEEASDAEVRQMFEVQIFGTWNVLRAVLPGMRAARRGHIINVSSILGLTAFPGWGLYCSAKYALEGLSDSLAAEVADLGIKVNVVEPGYTRTNFLRTSSLGLPRATASGYEAIREMTEAHLAMPGTQLGDPVKAAAAIITVADTGEAPLHQLLGSDSYGLARNRVEALTSDIEAGRDLAFSTDITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFE1</accession>
    <name>F4FFE1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25725"/>
    <dbReference type="EnsemblBacteria" id="AEB46243">
        <property type="protein sequence ID" value="AEB46243"/>
        <property type="gene ID" value="VAB18032_25725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25725"/>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027862_0_0_11"/>
    <dbReference type="OMA" id="RRMWLAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="548" mass="56029" checksum="315E960492BC2BBA" modified="2011-06-28" version="1">MAAGVAGLTGVVGLAAVGGVAARNQKSGERQEASNMPASAPKQHVSDADKAEETGGEESGKDDLGNRAGKGDPDDRDGKGKRFEGRERVKEVPCDTDKLIDAITLANRTDGATLKLAEHCTYTLTRHDEWGNGLPRINQPITLKGDKTRIERDPTAKPFRILNVGPGGELTLKGLTIKGGQLKDDKKKDDSKPRVRWGSKGEATAPTATPEAADAAPGTPAVAPQAAAAPVAAPQAAAAPGAGPGSEATPAPWPTGGHGHTPTEGAGLLVHQGGRAVVEHSTFVQNHAAGDGGAIANFGATRIDRSLIERNSAGGFGGGIFNAGTLQVEESEVVRNSAEEGGGGIANGSSDKYGIEGGTVYIFKSKISHNRTAGDGGGLADNGGTTSASHSEFTDNTAGSDVGGVLANVDSQLTLKHVLVAKNSTQGRAGGIGIGEGTKAVIEHSLVKENVSDGDGGGIFNFGFTVLRDTEVLANQAVGRYAQAGGIFNDGGKVSLIRSKVAFNFSTKKPGGIFTNNDRVEIDSKSTVIDNRPTNCLGSPVIPDRCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFE2</accession>
    <name>F4FFE2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734896.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25730"/>
    <dbReference type="EnsemblBacteria" id="AEB46244">
        <property type="protein sequence ID" value="AEB46244"/>
        <property type="gene ID" value="VAB18032_25730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25730"/>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027862_0_0_11"/>
    <dbReference type="OMA" id="PVWTDRA"/>
    <dbReference type="OrthoDB" id="1439222at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="566" mass="58804" checksum="861EFA899994AF5B" modified="2011-06-28" version="1">MSNYLANNDDRSTPKRRRKLWVASGVAGLTGVVSIAAVGVAGAGAVGGSNGVKWSTTQQVSRDDAQGEAEHHGKKAEHDGKKRDRDRHDERAREVPCDSDKLIEAITLANNRNGATLKLAEHCTYKLTRHDKWGNGLPKITQPITLKGDKTKIERDATAKPFRILNVGPGGELTLKGLTIKGGQTAPAKKVSAPEPRETWSQFSGSGEATDAVQGGKPLVTALQAAPKAPAAPPAEIDAAAAPATAQVDGEQEWQSEGQVETEGDWEPGRFDGAGLLVQPGGRADVHNTEFVDNQSGASGGAVANYGQTLLDESRVVDNTAFLFGGGILNVGVLKIEKSLVKHNQAIIGGAGVSNGLVKFKPYKGKLHHAGIDNGTLYVEKSEIEGNETTGFGGGILDIGGQTSVKHSKVSDNTALIAGGGILAAKKSQLTLAHSAVVKNSTAGVGGGLAVVDWSTATVDDSVIKDNVAGFFGAGLFNDDSKTTLRDTEVTGNRAVGPYATGAGIFNKGGWVYLTKTKVAHNTATNKPGGVFTTNDGVVLDDKSVITDNRPTNCLGSPVIPDGCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFH5</accession>
    <name>F4FFH5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734928.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25895"/>
    <dbReference type="EnsemblBacteria" id="AEB46277">
        <property type="protein sequence ID" value="AEB46277"/>
        <property type="gene ID" value="VAB18032_25895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25895"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051827_1_0_11"/>
    <dbReference type="OMA" id="WIGVERR"/>
    <dbReference type="OrthoDB" id="1105091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="430" mass="44487" checksum="2CC1C4F1196EF308" modified="2011-06-28" version="1">MPSATFLSRFRPAPDATASRARRSLVAVATRIGVPLGAALLALSIAPPAAAAPATPSPSAPGATGSSAGQQVDRFSVQPSGPKGPTGRNHFIYDVAPGSTLFDYVGVTNLSDRPLTFQVYATDAFTTVDGAFSLLPANQEPTDVGSWTRVEKKSVTVKPGKRADIRFEISVPTNATPGDHIGGVIAAVRQTGVTADGQQVQMDRRVAARVYLRVTGDVAPALTVESMDIEYQTPINPFGRTDMVVTYRLRNSGNVRLGGTGKVTVKAPFGWKLAQSEGLALPELLPGSVFTITERVTGVPPAVRLTAEVELTPAMADGTVLSSVRTDKSIWAMPWLLLAALLVVGVTVYLRIRRRRAAAAQANPGEKPAASDAPAPSGVPAPSGEAAVSTPAAPSGEAAVPEQAAPSGEAQQDPAVPAQPTAATDQPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFM7</accession>
    <name>F4FFM7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amylo-alpha-16-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736138.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02100"/>
    <dbReference type="EnsemblBacteria" id="AEB47504">
        <property type="protein sequence ID" value="AEB47504"/>
        <property type="gene ID" value="VAB18032_02100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02100"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019216_1_0_11"/>
    <dbReference type="OMA" id="WASATPF"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="338"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="680" mass="76593" checksum="EB97B4680D7B772B" modified="2011-06-28" version="1">MKELVSILDGNTFLVSDRCGDIEPSLDFPTGLFAFDTRFLSTWLLLLDGERLQPLSVDDAESYRTRYFLVPGEPTHFLDTKVSIIRSRAIGDSFDEDLTVLNHSGQDMTFTVRLEIAADFADLFEIKDTRGKQGDLTVTVEDQALRLAYRREAFHRETVVRSSAPAAIDKRGMTFSIRIGPHGEWTTRLGITTVIYGPRGQDVRTRLPMAGSRSTAAIQAEHAELVANAPKLGCDCEPLATAYQRSLEDLAALRYESIALGVRLMAAGLPWFMTLFGRDSIITSLQVLPFLPDTIPPTLMMLAGLQGHRIDDFRDEEPGKILHELRYGETAGFEEQPHSPYYGSADSTPLFLILLDEYERWTGDSQLVKQLEYTARAALAWIDTYGDLLGTGYLWYQTRNPRNGLENQCWKDSWDGISYSDGRLPGFPRATCEMQGYAYDAKLRGARMARLFWNDPQYADQLEREAAELKERFNRDFWLPDKEYYALALDGDGTPVDALSSNMGHLLWSGIVDESRAARVVEHLLGPRLFSGWGVRTLGDDQSRYNPIGYHVGTVWPFDNSIIAWGLWKYGFRQEAGQISESMLGASRYFDGRLPEAFAGYERDLTEFPVQYPTACSPQAWSAGTPLLLLRVLLGLEPEGEHLIIDPYVPQGMGRVELLDIPGRWGRVDALGRSRNRDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFQ2</accession>
    <name>F4FFQ2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4031 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02225"/>
    <dbReference type="EnsemblBacteria" id="AEB47529">
        <property type="protein sequence ID" value="AEB47529"/>
        <property type="gene ID" value="VAB18032_02225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02225"/>
    <dbReference type="eggNOG" id="COG4339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165258_1_0_11"/>
    <dbReference type="OMA" id="AFERDHY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025109">
        <property type="entry name" value="DUF4031"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13223">
        <property type="entry name" value="DUF4031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4031" evidence="1">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="102" mass="11553" checksum="CF987AA20EE6A839" modified="2011-06-28" version="1">MAAVIYLDRPAWPARGRLWSHLISDVSLAELHVFAEALGAPRRGFDRDHYDIPADRFDMAVWLGAEVRPSRDLVRLLYAANLRRPKHLHRVPRSAGQSAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG29</accession>
    <name>F4FG29_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43773">
        <property type="protein sequence ID" value="AEB43773"/>
        <property type="gene ID" value="VAB18032_13305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13305"/>
    <dbReference type="eggNOG" id="ENOG503250H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210342_0_0_11"/>
    <dbReference type="OMA" id="WQVAWAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="59" mass="6557" checksum="11B766255645AB5B" modified="2011-06-28" version="1">MAGGPERTILAVHVRGLDGMCAGCRVWWARLVPYPCWQVEWATSRQARASVARFLGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG30</accession>
    <name>F4FG30_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43774">
        <property type="protein sequence ID" value="AEB43774"/>
        <property type="gene ID" value="VAB18032_13310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13310"/>
    <dbReference type="eggNOG" id="ENOG50321PA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151362_1_0_11"/>
    <dbReference type="OMA" id="FLGWTRA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="98" mass="10848" checksum="88D6FEBF9EEF77AA" modified="2011-06-28" version="1">MTSHGPVMPIWSCGGCDLPWPCPTRRRELRAEYADAPVSLALYPGVCLVQAAEDMPWAPAGALHRRFIGWARQSPEVQQRSTATVPAEPDRQERHQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGK4</accession>
    <name>F4FGK4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_26205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26205"/>
    <dbReference type="EnsemblBacteria" id="AEB46339">
        <property type="protein sequence ID" value="AEB46339"/>
        <property type="gene ID" value="VAB18032_26205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26205"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2703808_0_0_11"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="73" mass="8025" checksum="019F6207D2FFCD98" modified="2011-06-28" version="1">MSGSDAAAACRLHEYAAAGIPFYWRIEQDPVHLYAYRLGPGGEREYELAADSADLVELTEPFDIKLPSAEIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGQ1</accession>
    <name>F4FGQ1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, deor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_02385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736194.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02385"/>
    <dbReference type="EnsemblBacteria" id="AEB47561">
        <property type="protein sequence ID" value="AEB47561"/>
        <property type="gene ID" value="VAB18032_02385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02385"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_0_1_11"/>
    <dbReference type="OMA" id="IRRDFDQ"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="261" mass="27465" checksum="4C3504F9C86DBB74" modified="2011-06-28" version="1">MDRYARWNALLEMLTESGRVTVEEAADRLDVSQATIRRDFDQLAQQQMITRTRGGAVANGVSYDLPLRYKTAKNSAEKQRIGAAAAALVTPGTVVGLNGGTTSTEVARALAVRPDLNTNAEGAQLTVVTNALNIANELLVRSRMKVVVAGGVVRPKSFELVGPLGGALLREVTLDVALLGVDAIDPHLGAAAHHEGEAAMNNLMVARAKRVVIIADSSKLGGHAFARICPVDRVETLVTDSGATPDVVDAFRAAGVHVICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGQ3</accession>
    <name>F4FGQ3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rok family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736196.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02395"/>
    <dbReference type="EnsemblBacteria" id="AEB47563">
        <property type="protein sequence ID" value="AEB47563"/>
        <property type="gene ID" value="VAB18032_02395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02395"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_11"/>
    <dbReference type="OMA" id="FEPEVIC"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="331" mass="32886" checksum="CE4579B454CCAC86" modified="2011-06-28" version="1">MSERDGRVVVALDVGGTGMKCALIRPDGAVVHAERHLTGADRGAEAVVDTILAVADGLVSTARTAGLTPTALGIVVPGIVDQTRGVAVWSANIGFRNVPLRDLATDRLGLPTALGHDVRAGGLAEARLGAGRDAGHVLFVAIGTGIAAAHVVAGAAATGAHGAAGELGHILVRPGGPRCGCGRSGCLEAIASASAVARRYTALAAGTTGDADTTSDGGSAAGPTPGPTVVTAAEVADRAAAGEELATRVWREAVEALADGLATGQALYDVQTIVLGGGLAQAGPGLFDPLRTALRERLTFHREPRLVPAALGDEAGCLGAALLALDQLEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGQ6</accession>
    <name>F4FGQ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase pa-phosphatase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736199.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02410"/>
    <dbReference type="EnsemblBacteria" id="AEB47566">
        <property type="protein sequence ID" value="AEB47566"/>
        <property type="gene ID" value="VAB18032_02410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02410"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078789_0_0_11"/>
    <dbReference type="OMA" id="RVADWAF"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="100"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="28122" checksum="82E3B1A07BDA3C3F" modified="2011-06-28" version="1">MRETTTVRGRVRLAPVRPAGWWFDALLLAALVGLTVALAAGWFFGIDRSVADWADAHRPTAARWVAIILNYLGQGTPLTLIAAGLSVLLAIRLRSVRPLFVPVAAFVLTLFTIGPLKVWTARPAPSASIKEPFLPPEQTLPLFQEDLPVRFAQSYPSGHVANAIVWYGVIALLLAPLLATLGRRLPRRVVPAIRIVPPAVVLCTTTYLGWHWLSDSVAGLLLGLLLDRILHRVPWDELPLPARSRNWDRPFTKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH30</accession>
    <name>F4FH30_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731317.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07620"/>
    <dbReference type="EnsemblBacteria" id="AEB42644">
        <property type="protein sequence ID" value="AEB42644"/>
        <property type="gene ID" value="VAB18032_07620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07620"/>
    <dbReference type="eggNOG" id="ENOG5031ZTS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1359101_0_0_11"/>
    <dbReference type="OMA" id="PITLHEA"/>
    <dbReference type="OrthoDB" id="2115923at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="22513" checksum="1A1564A3D0FEDF2E" modified="2011-06-28" version="1">MRYDGDNEYPFDTDNRAWRRLGDVTSEHFDAITWTRDPDERPILLTLRDMPTGDTITLAVLDSLEIRDPHVLLAVHTSGELDAHGPTSGATAAHSHAATLALDNATLAATRPAPLHNPAATTLPATCWVDLPADLAATLRPALHDARTAALVLLDRTGGRLAAVGPFPTHAAADAWQPDDGPGRTADRLIVPLHPITLHEAPAVTDTAPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHB1</accession>
    <name>F4FHB1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732556.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13885"/>
    <dbReference type="EnsemblBacteria" id="AEB43889">
        <property type="protein sequence ID" value="AEB43889"/>
        <property type="gene ID" value="VAB18032_13885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13885"/>
    <dbReference type="eggNOG" id="COG3022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071581_0_0_11"/>
    <dbReference type="OMA" id="SHFNKAT"/>
    <dbReference type="OrthoDB" id="1361974at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="27734" checksum="263A9FA8A345F4EA" modified="2011-06-28" version="1">MLILLPPSEGKAEAGAGRRLDLTRLSLPELNPVREQVLAALLTLSAGPAEAALTALGLGSGQQGELRRNARLERAATAPAGRIYTGVLYEALDLATLPAAAQRAAARQVLISSGLWGAVRLTDRIPPYRCPIGARLPGLGALPALWRPVLGPALTSAAGAAPVLDLRSGAYAAAWTPRGELAERTVTVRVLHEREVDGTAVRSVVSHFNKATKGRLVRDLLLHGVRARSADALVGALRDLKYTVCDQPSAPGRSRQIDVVVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI44</accession>
    <name>F4FI44_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
            <plasmid evidence="1 2">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713130.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30224"/>
    <dbReference type="EnsemblBacteria" id="AEB48008">
        <property type="protein sequence ID" value="AEB48008"/>
        <property type="gene ID" value="VAB18032_30224"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30224"/>
    <dbReference type="eggNOG" id="ENOG5032ERZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1844266_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB48008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="13656" checksum="D667298970C5AB78" modified="2011-06-28" version="1">MSGDQVAVVLDATALVAYVDGQVAVGELIAEVVDEGRTIGVPAACLAAAYAATSSEVSAALLTLLTTTPAVTVLPLGVEPGIDDARQVGVLARAAGGDIALGHAARTAIAHQAHLATTAPTPAAAVLPAGWSILDLNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI58</accession>
    <name>F4FI58_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713144.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB48022">
        <property type="protein sequence ID" value="AEB48022"/>
        <property type="gene ID" value="VAB18032_30294"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30294"/>
    <dbReference type="eggNOG" id="ENOG503236C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2144809_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12188" checksum="A83328A641932012" modified="2011-06-28" version="1">MAEQTAKAVRAETERAALGLLRERANLVGEAATARHDRDQLVEALRAANARYTERYDAAVQGGWTPEDLAKLGLDAPETTTSKRRRSRRPTSPSGPQQHDDQVVHADTGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1A7</accession>
    <name>F4F1A7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732610.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14155"/>
    <dbReference type="EnsemblBacteria" id="AEB43943">
        <property type="protein sequence ID" value="AEB43943"/>
        <property type="gene ID" value="VAB18032_14155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14155"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_0_2_11"/>
    <dbReference type="OMA" id="MLNAQFF"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="242" mass="25534" checksum="29877E16FC0BD5E5" modified="2011-06-28" version="1">MTLKLRSAGTSDCGLIRSGNQDALHAGAWLVAVADGMGGMAAGDLASSIAIEAMAPLDVETPEHALVAALQSGIQLATNRIRQAVAEDPQRQGMGTTLTALLFARTGSCLALAHVGDSRAYLFREGVLKQITRDDTFVQMLVDQGLITPDQAGSHPRRAVVTQALQGEEVSPTYATMLPWAGDRWLLCSDGLSNVVSAETLAEVLAEYPDRQQCARRLIDLALRAGGPDNVTVVVADVIDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1D0</accession>
    <name>F4F1D0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TM helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732633.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14270"/>
    <dbReference type="EnsemblBacteria" id="AEB43966">
        <property type="protein sequence ID" value="AEB43966"/>
        <property type="gene ID" value="VAB18032_14270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14270"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049564_0_1_11"/>
    <dbReference type="OMA" id="FGVWGPN"/>
    <dbReference type="OrthoDB" id="1896788at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008910">
        <property type="entry name" value="TM_helix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05552">
        <property type="entry name" value="TM_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="29945" checksum="E670703329607B8B" modified="2011-06-28" version="1">MPETFAARQVDIGNAVADMWRSVLLFVPRAIAFIAILVVGWLIARAVLKIVDAALERVGFDRAVERGGIKRALERTKYDASDILAKLAYYAVLLFTLQFAFGVWGPNAISNLISGVVAWLPRAFVAIVIVVIAFAIANAVRDIVSGFLGGLSYGKVLADVTAFFVIALGVIAALNQVGIATTVTTPVLIAVLATVAGILIIGVGGGLVKPMQNRWEDWLRRIADESRAVREQRQGAAAGRGDTQRQMADRAGAERSQAMAGGRATHQSGAASDETQQFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1E7</accession>
    <name>F4F1E7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732650.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14355"/>
    <dbReference type="EnsemblBacteria" id="AEB43983">
        <property type="protein sequence ID" value="AEB43983"/>
        <property type="gene ID" value="VAB18032_14355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14355"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="OMA" id="YKPGPDA"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="23556" checksum="D402C946AEF1FA3E" modified="2011-06-28" version="1">MSAPDTGRTVLVTGGSSGLGAAVVAAVARSGGRPLVLDRQPPADGVPWIECDLADTRGAEEATRRLVERTGGLDAVVTAAGIDVPGRLADVPGETWDRIVAVDLLATAAVIRAALPFLEASRGHIVTVASTLGLKAVSDATAYCAAKFGVVGFTRALAAELAGSVGVTLLVPGGMRTAFFDDRDAQYRPGPDAILNEPADTAAAIMFALSQPAGCAVRELVVCAEQETSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1R3</accession>
    <name>F4F1R3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_27076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27076"/>
    <dbReference type="EnsemblBacteria" id="AEB46488">
        <property type="protein sequence ID" value="AEB46488"/>
        <property type="gene ID" value="VAB18032_27076"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27076"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_1_3_11"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307324" evidence="2">
        <location>
            <begin position="41"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="121"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="473" mass="48537" checksum="378547C097BE54D2" modified="2011-06-28" version="1">MMRRMSVHRRTVLGLGLAAVTAAVAGCRQPASPSTPDAAAATGSPTGPAATHRPRAGASSAPPTAAAGEALGAAPGSSAEAAADGSLSGQAGIGTPSPLSRALTMELTRHLKPTAQNPNHPAYAGAVAYVQVDGKLVARAVVGKALRYGAGPVLLPESKQVAMRHDSIFDTASLTKVFTAILTLQQVDAGRIALDAPVVEYLPGFTGTGKSKVTVGMLLAHTSGLPVGAKVTGLPDDAARRAAVLATPLIKGATPGTVFRYSSVGLMVAAQLVEHVTGQRLDQALRSGITGPLGLRDTGFNPRTWLSSADQAARLVATDARSSRGLLRGTVHDDVANHLGGIAGHAGIFSTAADLTVIGQLLLDGGTYRGTRILSAETTARMLTNVNAGLPAVDAERPDRTSDHGLGVVLHQPWFMGKLATSRTFGHTGFTGTSLLVHPGRRIVLVLLTNRAHPNWSWANPDPVRVAVANLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1S4</accession>
    <name>F4F1S4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, luxr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_27131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007072219.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="SMR" id="F4F1S4"/>
    <dbReference type="STRING" id="263358.VAB18032_27131"/>
    <dbReference type="EnsemblBacteria" id="AEB46499">
        <property type="protein sequence ID" value="AEB46499"/>
        <property type="gene ID" value="VAB18032_27131"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27131"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="IARIYQK"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="222" mass="23344" checksum="1747F0CFEDA9A705" modified="2011-06-28" version="1">MTTSPTPATRTKVLLVDDHDLIRKGLRHAFERDRQFEVVGEAATAAEGVRQAGALQPDVVIMDLRLPDGSGLEATRALRKSSASMGIVVLTMYAGDDQLFGALEAGASAFVPKTAPADEVVAAARHAASSPSAFTAADLAEAMKRRLAPSGPQLSPREGQVLRLLADGMSVAGIAKQLFVSESTAKTHISKLYEKLGAANRAQALMTALRLGLLEAPDAPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1V0</accession>
    <name>F4F1V0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_27261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735175.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27261"/>
    <dbReference type="EnsemblBacteria" id="AEB46525">
        <property type="protein sequence ID" value="AEB46525"/>
        <property type="gene ID" value="VAB18032_27261"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27261"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_11"/>
    <dbReference type="OMA" id="CLQSANH"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="6"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="383" mass="39447" checksum="6396E792942D5DA4" modified="2011-06-28" version="1">MIPSSVYLDAATAAPLHPVARQALLAALDDGWADPDRLYTSARRARQLLDAAREAAAQTLGVRPDELSFTSSGTTAAHSAVLGGLRGRRRAGAVLVHSAIEHSAVLHAAQQHTAGGGTAVEVPVDRLGRLDLDVWSTAVTGSGVALAALIAASHEVGTLQPVEAAAAVCVDAGVPLYVDAAQSVGRMPVPPGWSVLTASARKWGGPPGVGLLVVRKGTRWESPWPADERESGRTPGTVNLPAVVAAAASLRAAAADAAAEAARLTPLVDRIRARVAAEVPDVEVVGDPEHRLPHLVTFSCLYVDGEALLHALDRRGFAVSSGSSCTSSTLRPSHVLEAMGVLSHGNVRVSLHSGSTEADVERFLAELPGIVADLRAQAGVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1X1</accession>
    <name>F4F1X1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">VAB18032_03170</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736350.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03170"/>
    <dbReference type="EnsemblBacteria" id="AEB47718">
        <property type="protein sequence ID" value="AEB47718"/>
        <property type="gene ID" value="VAB18032_03170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03170"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_3_2_11"/>
    <dbReference type="OMA" id="DMIVQTI"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="267"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="349"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AEB47718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="421" mass="44010" checksum="86A0512E6635125D" modified="2011-06-28" version="1">MALVVQKYGGSSVANAERIKRVAERIVAARKAGDDVVVVVSAMGDTTDELLDLANQVSPLPPGRELDMLLTAGERISMALLAMAIHNLGYEARSFTGSQAGVITTSVHGRARIIDVTPGRLKGALDEGAVVIVAGFQGVSQDTKDVTTLGRGGSDTTAVALAAALNADVCEIYTDVDGVFTADPRIVPNARHIKQITYEEMLELAACGAKVLHLRSVEYARRAGLPIHVRSSYSTNTGTMVTGSIEELPVEQALITGVAHDRSEAKITIVGVPDEPGAAARIFDTAASAEINIDMIVQNVSTEGTGRTDISFTLPKADGPTAMAALSKIQESVNFKGLLYDDHVGKVSLIGAGMRSHPGVAAGFFAALGQAGVNIEMISTSEIRVSVVCRDTDLDAAVRAIHEAFDLGGDTEAVVYAGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2U8</accession>
    <name>F4F2U8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="12" type="ordered locus">VAB18032_27431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735209.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27431"/>
    <dbReference type="EnsemblBacteria" id="AEB46559">
        <property type="protein sequence ID" value="AEB46559"/>
        <property type="gene ID" value="VAB18032_27431"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27431"/>
    <dbReference type="eggNOG" id="COG0321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_2_1_11"/>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="OrthoDB" id="1806796at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="35"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB46559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="22882" checksum="A045AD505ACDAB1F" modified="2011-06-28" version="1">MTTTTSGLTAVRAGVLDYTAAWDEQRRLHDAVVSGESGDTVLLLEHPSVYTAGKRTEPWDRPMDGTPVVDVDRGGKITWHGPGQLVGYPILRLPDPIDVVAYVRRVEQMLIDVCAEFGLTAGRVEGRSGVWVPEDDRGPARKVAAIGIRVAQGVTLHGFSINCDCDLTHFDKIVPCGIRDAGVTSLSAELNRPIPVTDVLPVVETHLPTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2V4</accession>
    <name>F4F2V4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamine synthetase</fullName>
            <ecNumber evidence="7">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_27461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735215.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27461"/>
    <dbReference type="EnsemblBacteria" id="AEB46565">
        <property type="protein sequence ID" value="AEB46565"/>
        <property type="gene ID" value="VAB18032_27461"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27461"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_11"/>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="8">
        <location>
            <begin position="104"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="4">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="474" mass="53199" checksum="F138879C0A7B37F0" modified="2011-06-28" version="1">MFANPEELLRYLKNEDVKFVDVRFCDLPGVMQHFNLPVESVDEGFFTDGLAFDGSSIRGFQAIHESDMLLLPDVATAFIDPFRAQKTLALNFFIHDPFTREAYSRDPRNVAKKAEAYLAASGIADTAYFGAEAEFYIFDSIRHETSAHQSFYYIDSIEGAWNTGREEEGGNRGYKTAYKGGYFPVPPVDHYADLRDSIVRRLIDTGFTVERSHHEVGTAGQAEINYKFSTLLHAGDQMQLFKYIVKNQAWAAGKTATFMPKPLFGDNGSGMHTHQSLWLNGEPLFYDETGYAGLSETARWYIGGLLHHAPSLLAFTNPTVNSYRRLVPGFEAPVNLVYSQRNRSACTRIPVTGSNPKAKRVEFRVPDPSANVYLAFSAMLMAGLDGIKNKIEPPAPIDKDLYDLPPEEWGDVKQVPGSLPAVLDSLEADHDYLLDGGVFTPDLISTWIDWKRANEVDPVRLRPTPHEFAMYFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F314</accession>
    <name>F4F314_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736425.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03545"/>
    <dbReference type="EnsemblBacteria" id="AEB47793">
        <property type="protein sequence ID" value="AEB47793"/>
        <property type="gene ID" value="VAB18032_03545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03545"/>
    <dbReference type="eggNOG" id="ENOG5034BBB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643870_0_0_11"/>
    <dbReference type="OMA" id="GQPRMES"/>
    <dbReference type="OrthoDB" id="349514at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="2">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="SseB" evidence="2">
        <location>
            <begin position="142"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="426" mass="46439" checksum="CF56313412E4E4F3" modified="2011-06-28" version="1">MTDPQPTTATGWQPTTAAERELLAAAEQEDGAAFLAALATGPLLLPVPAATAAAPVPWPTGHHEGVTHVMAYTSPAAIAAGLPGQDVTYRVSVLTDLAVDWPDERWVLAVNAGLPIAVRLTADELTSLAAAMVEAERPLREAVRQQDPDALMSALLRTELLLPLRPDGPATRDLDDPDFPWWCLPDEQGRPSLPVFTSEARLRQALGDHDLVAISSLQLTEHWPDASWQLSLNPETPLAAALPGEAVLTLRDWLGELRHVLDDAAEQERSRRVSAAYADPSTVGVPVPRPAAESTVDVDEGPDPDVPLRLQLVIPHRYLASYLDDGYDRAAGLVHAWYGPGRDTPVRLYRRLGLLGPGSPFEESDEWVAVLRWPPDESTPPEWGQGQPRMESLIVPNGTELRCLHQDGRDEFLARFDATTRRWSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F372</accession>
    <name>F4F372_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nad(P)h quinone oxidoreductase, pig3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736483.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03845"/>
    <dbReference type="EnsemblBacteria" id="AEB47851">
        <property type="protein sequence ID" value="AEB47851"/>
        <property type="gene ID" value="VAB18032_03845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03845"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_11"/>
    <dbReference type="OMA" id="VWSNVFM"/>
    <dbReference type="OrthoDB" id="1027479at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="325" mass="33803" checksum="09EEC2725C528962" modified="2011-06-28" version="1">MRAIVVSEPGGPEVLSWSEVPDPQPGPGEVLVDVRATAVNRADLLQRQGHYPPPPGASEYLGLECSGVISALGAGVDGWAVGQQVCALLAGGGYAERVAVPVGQLLPVPDGVDLVDAAALPEVASTVWSNVVQVARLAAGETLLVHGGGSGIGTFAIQLGAALGATVVATARAAKHDRLRALGAAHLIDYREQDFVEEVRRVTSDAGADVILDIMGASYLGRNVAALAYDGRLVTIGMQGGRKGELDLGALLAKRGTVAATALRSRPLEQKSAIVRGVREQVWPLVEACRIRPVIDRRMPISEAADAHRLVESSDHVGKVLLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4F387</accession>
    <name>F4F387_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6 9" type="synonym">ksgA</name>
        <name evidence="9" type="ordered locus">VAB18032_08465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731482.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08465"/>
    <dbReference type="EnsemblBacteria" id="AEB42811">
        <property type="protein sequence ID" value="AEB42811"/>
        <property type="gene ID" value="VAB18032_08465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08465"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_1_1_11"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="36"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="29814" checksum="6D5AF97B9B162650" modified="2011-06-28" version="1">MAADLLGPAEIRDLAARLGVAPTKRLGQNFVHDPNTVRRIVTTAGLTGDDVALEVGPGLGSLTLALLPVAAHVHAVEIDPTLAAALPDTAARHAGPHAARLTVHHADALRITGAELTDPAPTALVANLPYNVAVPVVLHLLAVLPSLRHGLVMVQKEVADRLVAGPGSKVYGIPSVKLAWYAHARAAGKVPPNVFWPVPNVDSGLVAFTRREPPRADVPREQVFAVVDAAFAQRRKTLRAALAGWAGGADRAAAALTAAGVDPGARGESLTVEQFAAVAASARGGTSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Q5</accession>
    <name>F4F3Q5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21280"/>
    <dbReference type="EnsemblBacteria" id="AEB45356">
        <property type="protein sequence ID" value="AEB45356"/>
        <property type="gene ID" value="VAB18032_21280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21280"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016759_0_0_11"/>
    <dbReference type="OMA" id="IHRHLCA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="652" mass="70237" checksum="E6E9C4CAFE3D33F3" modified="2011-06-28" version="1">MTRRIFALLVGIDRYRAAGQLQGCHNDVLAVRDYLQVRAGVSDPRAIRLLANEDATRSAVIAGLREHLGQAGPGDTALFWFSGHGSWAAVPKELSHLEPSGQMQTLVCHDSRHDEVPDLYDKELLLLCDEIAGTGAHLAVVLDSCHSQSATRDLVRYAPASTTPPRLEALLPQLRRVLTRPPAQHVALAACRTDETAGETWADGRAYGLFSWSLLSAMRRLAPSATYRDLLVAARCEVERQSRQQVPQLEPVTPGIADQPFLGGRVTLPAIGIRMRRIRGEWEIDAGSCHGLSLPSAAQDVRVAVPGPLLREARIVRVHPGRSVVEPLGWEPDEDTQYPVVLSRVPMPRVTVAVDGVHRSAADPVLTALASAAPGGGPSAHVRPVEGDDERSADLLLDVHLPDRVRIRDADGFPLCAELAVDDGGRRAVLALEHLARVHQIKALVNPISGLAGAVGMELVEARPGESTAPAYRPPLLPAGDGTLHLRYRWEQGTWRPPTVFVQLRNNSGRKLFFVLLNITERHRVHATLFAGDHVAPGHVGAALYGRAVEFTIPAGDPVQPGARTRDWLLLLAAEEQFSSAPFELPAIEDISADRRRSPLAVAGLLGRLGLAAVHRDAGAAGTGASDWITLAVPVVTEVPAGRGAHLAGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Z8</accession>
    <name>F4F3Z8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735294.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46644">
        <property type="protein sequence ID" value="AEB46644"/>
        <property type="gene ID" value="VAB18032_27856"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27856"/>
    <dbReference type="eggNOG" id="ENOG5031V74">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2151117_0_0_11"/>
    <dbReference type="OMA" id="VVTPTYD"/>
    <dbReference type="OrthoDB" id="2033644at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="134" mass="14189" checksum="BB2FC7D9B859CBF4" modified="2011-06-28" version="1">MFGTNLLERRSKPERIADDAWHHLVSAVSTAGDNLRDTARSARHTSAGLADDAGELVGSAAEEARRRATRAFDALAGRRPALPWTLLIGAALVGAALGWAAGTAARAAGSRDRSVDDIEFVDVERPDSPAETDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F421</accession>
    <name>F4F421_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735317.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27971"/>
    <dbReference type="EnsemblBacteria" id="AEB46667">
        <property type="protein sequence ID" value="AEB46667"/>
        <property type="gene ID" value="VAB18032_27971"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27971"/>
    <dbReference type="eggNOG" id="ENOG5031D6S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803838_0_0_11"/>
    <dbReference type="OMA" id="RTKDWAV"/>
    <dbReference type="OrthoDB" id="743536at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="345" mass="37426" checksum="4B99820F0C7CCE3F" modified="2011-06-28" version="1">MPRVTVTVRDSSGQTATAAANYSLTPPVLGGYYLSGNADPTTDMSGGNFRSLTQYRSFADSNIFPGYNRPWLVTLGRSGVQMNMVLELKHYGAGDTGSQTFTVDGVRYTVPAPAMTIQQRPGTVWPKAYGYSQVISGQCDGLFARALSQYRTLGFGVNIQLASELDTDHEFGTTEAGKAYTWAESDARAVQAMTYIVNWFRVKALPSGTTFSVGVGGFDRASFTRTHPESLMSRLDYLQWNVYATSASDTALARFRRTKDWAVADLGPVALSRPVIVAEWGVRVAEIPDQAAWIATVPAAIARLNAERGPIFARTNYFNSGWGTLSPKATGLAALRSAYARSPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F481</accession>
    <name>F4F481_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5926 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736526.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04060"/>
    <dbReference type="EnsemblBacteria" id="AEB47894">
        <property type="protein sequence ID" value="AEB47894"/>
        <property type="gene ID" value="VAB18032_04060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04060"/>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075039_0_0_11"/>
    <dbReference type="OMA" id="RYKACHG"/>
    <dbReference type="OrthoDB" id="1424843at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045970">
        <property type="entry name" value="DUF5926"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19348">
        <property type="entry name" value="DUF5926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5926" evidence="1">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="32075" checksum="F60DE459B156BD10" modified="2011-06-28" version="1">MSKRRKNQRAATPSAKRERVRDVFVPRPFEGLADEPEWIALRELVPAASAPLRLTPALTEEYGDRPITLATVLPMAAPAMSRQDGRVFIGLQRHQQSGDVSRDLAESLLCALRTEPGAPVAVPPLPGPGPRLQDILADGPLEITLHEGFEFWLVPEAVDDPTVQASLERANAAIYPTVRLAAAPAAYWCRVPEKAHVRWVLPEDEEAALDALARLSAAGSLTLGESTKFAGMFRAHGRLVPVWDLPEDVPASDWEEPVAGFAKRYVEALAETGPLDAAARRSRQGLLGRQLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F482</accession>
    <name>F4F482_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arginine deiminase</fullName>
            <ecNumber evidence="4">3.5.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04065"/>
    <dbReference type="EnsemblBacteria" id="AEB47895">
        <property type="protein sequence ID" value="AEB47895"/>
        <property type="gene ID" value="VAB18032_04065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04065"/>
    <dbReference type="eggNOG" id="COG2235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052662_0_1_11"/>
    <dbReference type="OMA" id="ERATMHL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="395" mass="42995" checksum="AA7B9151F1A6AA68" modified="2011-06-28" version="1">MDSEVGRLGSVLVHRPGPELARLTPRNNDSLLFDAIPWVGRAQEEHDGFADALRARGVEVLYLTDLLTETLAVADARHELTEQVLDSPRLGDTLRARVAAHLSYLDPAALAGVLVAGLAHEELRIGRDRPGGLVYTLMDRHDFVIEPLPNLLFTRDSSLWIRDRVGVTSLAMPARRRETTLTDAIYRHHPRFANTEFVYRPELEHLEGGDVLLLAPGVLAVGVGERTTPAGAERLARRVFAAELAHTILVVPIAQERATMHLDTICTMVDVDAVLMYPNVATSLSAYTVIAGADGDDPRVDGPAPFLRAAADAMDLDQLRVIDTGLDPVTAEREQWDDGNNTLALAPRLCVGYERNIETNAQLERAGIEIIPIAGSELGSGRGGPRCMSCPLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F490</accession>
    <name>F4F490_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736535.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04105"/>
    <dbReference type="EnsemblBacteria" id="AEB47903">
        <property type="protein sequence ID" value="AEB47903"/>
        <property type="gene ID" value="VAB18032_04105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04105"/>
    <dbReference type="eggNOG" id="ENOG5031MNG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137019_0_0_11"/>
    <dbReference type="OMA" id="LISEWQV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="235" mass="24564" checksum="076D5DC28BE19E0F" modified="2011-06-28" version="1">MTHDLPIPRQEDRSESTSVLEWGTEDEKTTSTSRWRSALGGLGHDHRVPLLLVGLGVAATLASLLGEWVTVTLPTGSERIELPSNVSEIGGLGVGYLVGMLMLGVSVALALRGTDNVRANARVAGLALAVGLVAVLVATAVALEDGGGRAALAYSTEDGFAVELGRGLVAAFAAVLLFAIALARTTTRPEGATSEPGRRQPRPHRQIDDTDTDEDEGGRPIDITVTPTVPFAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4A7</accession>
    <name>F4F4A7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiamineS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04190"/>
    <dbReference type="EnsemblBacteria" id="AEB47920">
        <property type="protein sequence ID" value="AEB47920"/>
        <property type="gene ID" value="VAB18032_04190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04190"/>
    <dbReference type="eggNOG" id="COG1977">
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    </dbReference>
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    <dbReference type="OMA" id="KVTVRYW"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="81" mass="8383" checksum="3DB6071C12E81780" modified="2011-06-28" version="1">MATVTVRYFAGARAAAGLSEETVPAGRTLDGLLTELAERHGRLVPVLAVANFLVDGVTCHDRDKPLPAGVTIDVLPPFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4X8</accession>
    <name>F4F4X8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB45467">
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        <property type="gene ID" value="VAB18032_21835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21835"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="RGLGGTW"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="414" mass="43917" checksum="EF73621A63936325" modified="2011-06-28" version="1">MSSTRTSIDPTPMPQLDVAADLLTLLADTSTEIRCDPQLEALTLAVAADLPVLLWGEPGIGKTAALTQLAASLDLPLTTVIASVHEPSDFAGLPVVGDDPAHQGVPMAPPDWAVRLVRAGRGLLFLDELSTAPPAVQAALLRLVLERRIGSLRLPAGVRIVAAANPRSSAADGWELSPPLANRFVHLQWTHDHETVVRGLGGTWPRAVLPRLDPQRLPEAVTFARRAVCGLLSARPALVHRLPTGEAGRGGPWPSPRSWEMTLRLIAFATAAGSSREVLSLLVRGAVGDGPGLELLASLDRMNLPDPEVLLADPDAAVLPERGDLRQAVLDAVVEAVRRRPERARWDAAWDVLVRALQTGAPDLVVVPASTLARLRQEGWDVPASIEQLAGAVSVSRRADRTAARVAAVAGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F535</accession>
    <name>F4F535_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_28231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28231"/>
    <dbReference type="EnsemblBacteria" id="AEB46717">
        <property type="protein sequence ID" value="AEB46717"/>
        <property type="gene ID" value="VAB18032_28231"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28231"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_3_1_11"/>
    <dbReference type="OMA" id="ALMGDGI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="293" mass="30155" checksum="6B72239AD3F1BF35" modified="2011-06-28" version="1">MGHELTLFQYEYMQNALIGALVIGVAAPALGIYLVQRRLALIGDGIGHVALTGVGAGLLFGTSPVIMAVIAAVIGAVAIELIRERGRTSGDLALALLFYGGIAGGVVLVGLSDSTSANLNAYLFGALTTTSRSDLVTIAVLGVAVLITMIALRPALFAVCQDEEYARVSGLPVRALNLLLAVTTAITVTIAMRAVGVLLISALMVVPVATAQQVTRGFRATMTAAMTLGLFAAGAGIWVAAVADTAPGASVVVLAIASFVVITLFAAGWRRIRRTRPEPVPAPEPPEVVLDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F546</accession>
    <name>F4F546_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_28286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735378.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28286"/>
    <dbReference type="EnsemblBacteria" id="AEB46728">
        <property type="protein sequence ID" value="AEB46728"/>
        <property type="gene ID" value="VAB18032_28286"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28286"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_6_0_11"/>
    <dbReference type="OMA" id="IITLAYY"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="266" mass="28054" checksum="2EC75B450172111E" modified="2011-06-28" version="1">MIDLEPVARPDAPLARRNPVAKLAAALLFAFPLLATLDPVAPAIALAVELAVLPLFGLRYRVLLRRAWPLLLAAGGVLVTLVLFAADRSGRVLLDAGPIMVTSSVLLTALGLVLRLFAVALPGVIVFATTDPTDLADALVQNAKAPARFAIGALAAFRLLPLLGQEWQMIAMARRARGVEAGRNPVAKLRLFASTAFTLLVGAIRRGTRLAVAMDARGFDSTTGRTFARHQPFSTADWLLLICAPALAAAALTISITLGTFTPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F548</accession>
    <name>F4F548_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735380.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28296"/>
    <dbReference type="EnsemblBacteria" id="AEB46730">
        <property type="protein sequence ID" value="AEB46730"/>
        <property type="gene ID" value="VAB18032_28296"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28296"/>
    <dbReference type="eggNOG" id="ENOG5031WG5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206290_0_0_11"/>
    <dbReference type="OMA" id="MIWNFAR"/>
    <dbReference type="OrthoDB" id="2071897at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="6857" checksum="B63878EFE836B292" modified="2011-06-28" version="1">MIRKRVAQWAVMAVAVPLAAAGARRLSHTLESRRGPSGASRMLTRGADLLRPQKARRRRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F599</accession>
    <name>F4F599_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04325"/>
    <dbReference type="EnsemblBacteria" id="AEB47947">
        <property type="protein sequence ID" value="AEB47947"/>
        <property type="gene ID" value="VAB18032_04325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04325"/>
    <dbReference type="eggNOG" id="COG1971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459130_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="730" mass="79201" checksum="67D804F53860EC4D" modified="2011-06-28" version="1">MTTDQSPSGGPRPTTRGRRDTRIQAAAGGRADADGTDDQARKPTGGVDPTGGKAEAQTDAAGKTKAPGNETRTPTDEAKAETPRDEAKPKTPGDEAETPASDKDKKSAAGDGKDGDGKDGDGKDGDGKDGDGKDKGDVEKKDPWAAFGPAPEPVPRWYGRLARRTGRLLIHEWTLAALGSLVLAVLMTWPALRYPRHTLPHDYWDPSLQAWQMAWSGHALRTDPAQLWHSNAFFPERWSFAFSDTLLGYAPAGLIGSGPQDALLRYNIMFVLAHALATFGAYVLARQLGASRIGSAVAGVSYAYAPWLLSQAGHLHVISNGGIPLALAMLARGHGWSLRHGYRPERRHDGWVYTGWLVAAWQLSLGFGIGLPFAYVLAGTVVVAMLIWFAKRIFWRVKRPFGQRLFVADLIGGLIFAGVGVLMAIPYFTVAQLHPQAERSIRDIAAFSPPANSFVTAPAESRIWGGLHEGARSVLPWHPEMTLLPGFALYALALGGLFFSIWTIRQRLFLLAGVLVAMTLSMGTRFFGGDFTYVPLFDHLPGWNGIRTPGRLMIWATLLLGLLAAGAVSAFSERVREVSAQRIPSWPSPWLRLATLLPLLLVIVEGTNTTPHPVVPPQPAAMRTVGGPLLVLPSGQNHDQPVMLWSTTRFQDIVNGGSGFTPRQLADVRQVTMTFPDQTSVDYLRTLGVRNVLVLRDEIAGTPWEVSVDAPLDGLDITREEMGSVLLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5A5</accession>
    <name>F4F5A5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736584.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47953">
        <property type="protein sequence ID" value="AEB47953"/>
        <property type="gene ID" value="VAB18032_04355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04355"/>
    <dbReference type="eggNOG" id="ENOG5031YZM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314946_0_0_11"/>
    <dbReference type="OMA" id="QMEANDA"/>
    <dbReference type="OrthoDB" id="2228538at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307426" evidence="2">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="20850" checksum="04DE865AE3CC40AE" modified="2011-06-28" version="1">MGGAIAGVLLVSALTACAPPDSAPSAGPTSPTVPASAAVPATPIVEARCAAAAGTPPEVVAKPSGTVTSPGTPEAVGSGHPMTDEQLRQEEFLRQQAANKAFRQRGTLDPAATGGAHACAAEVQRVLNLLTVGGQDAPEEEAVRQAVADTGLLDVVVRPPGRLDLGPGDGLVFSGWTGRACVFGSVRQDDITVEFGTRIADGGCLPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5J9</accession>
    <name>F4F5J9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_09565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731702.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09565"/>
    <dbReference type="EnsemblBacteria" id="AEB43031">
        <property type="protein sequence ID" value="AEB43031"/>
        <property type="gene ID" value="VAB18032_09565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09565"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_11"/>
    <dbReference type="OMA" id="CIDAGFV"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="36205" checksum="D5801FCF55CEED9F" modified="2011-06-28" version="1">MTRYGPMFGPDVTFLGVPPCTIEEPVTYADADVVIIGAPFDGGTSHRPGTRFGPSAIRQACYLPHDGSRPSLALRVDALKDLCVYDAGDVEMFSGDIDRSLAALETAVYAVTSAGAIPVILGGDHSIALPDATGVARHHGLGRVSLLHFDAHADTGDIEFGSLHGHGQPMRRLIESGAVRGDRFLQIGLRGYWPGPETLRWMAEQRMRSYEMTEIVARGLDDCLSEAFDIATDECEGVFLSVDVDVVDPGMAPGTGTPEPGGFTSRQLLDAVRRACYELPIVGVDVVEVAPPYDHADITAYLGNRIVLEALSAIARRRHDATGTPPWTPTQPLLDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5N5</accession>
    <name>F4F5N5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_15680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732912.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15680"/>
    <dbReference type="EnsemblBacteria" id="AEB44248">
        <property type="protein sequence ID" value="AEB44248"/>
        <property type="gene ID" value="VAB18032_15680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15680"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_11"/>
    <dbReference type="OMA" id="NEAVMHM"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="373" mass="40988" checksum="5D1C9B20E647DD0B" modified="2011-06-28" version="1">MSTNIHRGLAGVVVDATAISTVINETNSLTYSGYAVQDLAASRTWEEVAYLLWHSDLPDATQLADFRAAEAAQRSLDRCGQELLRKLPETCHPMDVLRTAVSYLGAQDPTEDHADRTANQAKALSLFAKLPTVVALDLRRRRGQDPIPPDPTLGYVENFFHMCFGEEPPADVVRAFETTMILYAEHSFNASTFAARVITSTLSDLYSAVTGAIGALKGPLHGGANEAVMHMLVEIDDPARVEGWLDEALAAKRKIMGFGHRVYKNGDSRVPIMQAALDNLIATYADDRTRRLAEIYTRLQGAMLDRKGIHPNLDYPSALAYHLMGFDIATFTPIFVMSRITGWTAHIVEQLTANVLIRPLSVYAGPQPRPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F638</accession>
    <name>F4F638_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_28596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735439.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28596"/>
    <dbReference type="EnsemblBacteria" id="AEB46790">
        <property type="protein sequence ID" value="AEB46790"/>
        <property type="gene ID" value="VAB18032_28596"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28596"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_11"/>
    <dbReference type="OMA" id="MTCYDVR"/>
    <dbReference type="OrthoDB" id="1650683at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="265" mass="28830" checksum="D830CBD59BCC2F8E" modified="2011-06-28" version="1">MRVAVCQLNSRDDRKANLVAAEALIDRAADAGADLVLLPEYVDYLGPGAGMPAPEPVDGEVGQFFAAVARRRGIWVIAGSFHEAGPDPEHTWNTMLVFDRAGALAASYRKIHLYDVEIPGRVSYQESATVAPGDQPVVVEIEGLRVGLSICYDLRFPELYRRLATDGGAHLLVVPAAFMMHTGRDHWEVLLRARAIENQCFVAAAGQTGDHEPGRTCYGRSMVVDPWGTVLSQVADGPGFAIADVDLDRLTRIRAELPSLANRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F682</accession>
    <name>F4F682_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28816"/>
    <dbReference type="EnsemblBacteria" id="AEB46834">
        <property type="protein sequence ID" value="AEB46834"/>
        <property type="gene ID" value="VAB18032_28816"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28816"/>
    <dbReference type="eggNOG" id="ENOG5033P1U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120923_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="171" mass="18766" checksum="CC03C7D3F692C885" modified="2011-06-28" version="1">MEEAVRVGPPTPRQPGDDCPGGEHPLIADMSATVEPVTLRRICDALDLLDVRYLADGDGNLLAMWERHAVLVTLEGPEDEILVLRARPHATVPPDWADRAYRVVNEWNHTRRFCKAYVGDATERGQLPIYAELQVPLAAGAHDALLVELLDCGAAVATSFVDWLHDEGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6D5</accession>
    <name>F4F6D5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731752.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09815"/>
    <dbReference type="EnsemblBacteria" id="AEB43081">
        <property type="protein sequence ID" value="AEB43081"/>
        <property type="gene ID" value="VAB18032_09815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09815"/>
    <dbReference type="eggNOG" id="ENOG503356Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_857407_0_0_11"/>
    <dbReference type="OMA" id="WRDGYVP"/>
    <dbReference type="OrthoDB" id="1591184at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312725" evidence="2">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="318" mass="32830" checksum="15536C91CA7BF737" modified="2011-06-28" version="1">MRLFAARLGLPLMIVVAGCAPAGTGTAPTGPISSADDPGPFDRRATAVAEAWQPGPGWREGYVPLQDPAVLIGEANFTPATQTAFQAGWYRKPADLPVRQPDDGTIRFPDGQLRVPLVSATDAFLALTRGSDPPSCPGSKEPAIPPPPAPGGKPDDTVASRPQGECVALTISKVELGTAPLRTSRGEAQVPAWLFTVEEIGAVVAAAAVAPHAVDAVPEPVAPSDTAPEGLVAAQDIVEVDGTRLAFRLGVGSCDTDITPLVQERDDIVVVGGTVVRSTDVCDAMLRMEPVEVTLKEPLGARPVLDALTGAPLRIGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6E0</accession>
    <name>F4F6E0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731757.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09840"/>
    <dbReference type="EnsemblBacteria" id="AEB43086">
        <property type="protein sequence ID" value="AEB43086"/>
        <property type="gene ID" value="VAB18032_09840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09840"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_11"/>
    <dbReference type="OMA" id="CGTWAWG"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="14"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="322" mass="34950" checksum="689149A2F72311F7" modified="2011-06-28" version="1">MRYVRLDTPKSLSKIGLGTWQFGSREWGYGPDYERLAADIVRRAVELGVTVFDTAEVYGFGRSERILGAALAADRDKVTIATKIFPVLPVASVVQQRAVASAARLGVTSIDLYQVHQPNPVVSDQSTMRGMRALQDVGLVGEVGVSNYSLRRWQVAEAALGRRVLSNQVRYSLLDRKPEEDLLPYAEQAGRLVIAYSPLAQGFLSGRYDAHHPPVGAIRRANPYFLPENLVRGTALIETLRQVAAAHDATPSQIALAYVLRHPNVVAIPGASTVEQLERNAAAAAIDLTEDEYAALVNAARAFRPVTGLAAVPGMVRARAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6G9</accession>
    <name>F4F6G9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type iii restriction protein res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731786.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09985"/>
    <dbReference type="REBASE" id="34483">
        <property type="entry name" value="VmaORF9985P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43115">
        <property type="protein sequence ID" value="AEB43115"/>
        <property type="gene ID" value="VAB18032_09985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09985"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005588_1_1_11"/>
    <dbReference type="OMA" id="DEFHHAE"/>
    <dbReference type="OrthoDB" id="16977at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021835">
        <property type="entry name" value="DUF3427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11907">
        <property type="entry name" value="DUF3427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="330"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="540"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114784" checksum="EDBE58BEA8CE6358" modified="2011-06-28" version="1">MEELAPGIYEHIVTRGLADRLKRVESTLLQQECLDPADAPHALARHIATLAHRALHAVTGGDGKLHRQVELANRIAETIAAHSTQAATIDDQVTDVERLLHAVAAPPISTAAPAFPVRPTTPLSTGALLVNGRHQPRIGHEVAYEMASADSVDLLCAFIKWHGLRLIEPAIQELTARGGRLRVITTTYMGATDQRALDRLAELGADIKVSYETRTTRLHAKAWLFRRNNGMTTAYVGSSNLSKSALVDGVEWNVRISNVEQPHVIDTFTATFEDYWNDPAFEAYDPAKDGERLGYALRGERAGEAPTEIANLDVRPYPYQAEVLADLDAERRVHGRWRNLVVMATGTGKTVVAALDYRRLHKAGDVDSLLFVAHQEQILRQSRSTFRQVMGDGSFGETLVAGDKPKQWQHVFASIQSLHRQEIDPEQFDMVIVDEFHHAEAKTYARLLERLRPRVLLGLTATPDRADGRDVRRWFDGHAAVELHLREALDRQLLAPFHYFGLHDDVDLSHLQWKRGQGYDRSELENLYTGNQARARLVLRAAQRLVDVGRMRALGFCVSIGHAEFMADWFTQRGVSAAAVTSEVSRPEQRDLIRDFKAGKLRVLFTVDLFNEGVDLPMVDTIFLLRPTESATIFLQQLGRGLRLDDDKPCLTVLDFIGAQHANFRFDLRWRALTGVSRRQVHGAVQQDFPMLPSGCHIELDRVAKEVVLRNLERAVPSSKNSMVAELRQLGDVTLAEFLRDTGLEVGDVYRSATLGGWTGLRRLAGVETSKPGAYDRELGRAIGRMLHTDDLDRLALWEQVVAGEPVADGRLLDMLHFSLWGPNVPLSQRDERLARLRAEPARCVELRQVAEVLREQIHRVTEPVGLNQVPLRVHARYSRNEACAAFGMPNPGSLREGVKWLESEQADIFFVTLVKSEQHYSPTTMYADRAITDTLFQWESQSTTSSASATGQRYIHHVERGSTVHLFVRETRVADRDLGAPAYLYAGPMTYQEHSGDRPMRIIWRLQHPLPADMYAAARAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6L0</accession>
    <name>F4F6L0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732998.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16160"/>
    <dbReference type="EnsemblBacteria" id="AEB44338">
        <property type="protein sequence ID" value="AEB44338"/>
        <property type="gene ID" value="VAB18032_16160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16160"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_2_11"/>
    <dbReference type="OMA" id="YLWHDTG"/>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="His_deacetylse_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="36"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="377" mass="40035" checksum="0181A0FF46068129" modified="2011-06-28" version="1">MTTGYVFHPEYLWHDTGTSAGLLPANPPAGIQPAVHIENPEAKRRAHELIHVSGLLAELTVIEPRRATMAELLRVHTGDHVQHIKTQSDLRGGGDAGDGFSPVGPGSYAIARLAAGGLIELVTAVARGEVTNGYALTRPPGHHATADRGMGFCLFNNIAVAARHAQAELGLTRIAIVDWDVHHGNGTQSIFYTDPSVLTISLHQAGCFPPDSGWIRENGAGDGTGYAINVPLPPGTGHAGYLHAMTEIVLPALERFAPDLILLANGFDANVFDPMARQMLTAASYRAMTRMLTDAADRLCHGRLVAAHEGGYSPFYVPYCALAFLEELAGTTTRVTDPLAVVADYAAEPLQPHQKAVIDEAAQLVSRIGAHEIAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6M6</accession>
    <name>F4F6M6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44354">
        <property type="protein sequence ID" value="AEB44354"/>
        <property type="gene ID" value="VAB18032_16240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16240"/>
    <dbReference type="eggNOG" id="ENOG50328B1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098218_1_1_11"/>
    <dbReference type="OMA" id="WDIDLEW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="173" mass="20241" checksum="5C1C3A95F8F6669B" modified="2011-06-28" version="1">MEMSRVQIENWLSDAIWLTVTGDEKLFDYRSSERSVMFRIGHYLAMGIEAHLGPEWHVDVEYNRQGDQGVPKKAWALRRSEKDKARSVLPDLIVHRRGMRGRESNLLVVESKKPDCPDTDADYDRKKLQAYLDEHGYQYAVFLKLGRTPTWEWLSDDQSVLTDVRRSGRFRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Z6</accession>
    <name>F4F6Z6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735509.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28946"/>
    <dbReference type="EnsemblBacteria" id="AEB46860">
        <property type="protein sequence ID" value="AEB46860"/>
        <property type="gene ID" value="VAB18032_28946"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28946"/>
    <dbReference type="eggNOG" id="COG5606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052958_0_0_11"/>
    <dbReference type="OMA" id="AFDLGHW"/>
    <dbReference type="OrthoDB" id="1093232at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="317" mass="34567" checksum="8C6198722DD9B8F4" modified="2011-06-28" version="1">MSLALPNDSIESLQEDVTLLARSGGMAAFDVFSSARRLRDEARALVERTRRPVELADLYVVIGQSAALMASTAFDLGHWNESAALARASTQYADLAGHASLKAWTYGLQMTLANWRNEPDSALSYFARAMRTAPEGEPRLRLRYVAARSHALLADSDSVAAVLEAAQRDREAAADRPDELATVTGGEFAFGDARAAACAAAAWLDLRNGEQAARYAREALQVYEALPSPRRPYSQINGTQIDVAAAHLHMRDKDGAADALRTVLDLPPQKRNVSLTGRLSRIEHMLSQSPWDRDADARQLAERIAAWLSQTSARPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F745</accession>
    <name>F4F745_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF3817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_29191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735558.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29191"/>
    <dbReference type="EnsemblBacteria" id="AEB46909">
        <property type="protein sequence ID" value="AEB46909"/>
        <property type="gene ID" value="VAB18032_29191"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29191"/>
    <dbReference type="eggNOG" id="ENOG50330UF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120964_1_3_11"/>
    <dbReference type="OMA" id="TRYRVMA"/>
    <dbReference type="OrthoDB" id="1709780at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="109" mass="12238" checksum="6A027D652F130F38" modified="2011-06-28" version="1">MRAALTRYRVIAWIVGVVLILLVVIGMPLKYGFDEPIVVETVGQAHGFLYMLYLVATFDLSRRVDWPLKRMILVMLAGTVPFLSFWAERRVSTLVLAQHAEPAPQPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F748</accession>
    <name>F4F748_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase, sigma 70 subunit, rpod subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_29206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29206"/>
    <dbReference type="EnsemblBacteria" id="AEB46912">
        <property type="protein sequence ID" value="AEB46912"/>
        <property type="gene ID" value="VAB18032_29206"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29206"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_3_11"/>
    <dbReference type="OMA" id="RRVQREF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="333" mass="37105" checksum="C7A0FB273D597D94" modified="2011-06-28" version="1">MGVGMASNRVTGAIEGTVGNVDKNIGMRTDEVAEERDLVGVYLHEISRTPLLDAAKEVDLSKAIEAGLYAEHLLGEDRVPEGVTRDELTRLVAEGERAKDLFIRANLRLVVSIARRYVRSGMPMLDLIQEGNTGLVRAVEKFDYERGYKFSTYATWWIRQAISRAIAQQERTVRLPVHLVEDVNRMRNVARQLTRELGSDPEPEQIAAALGVTVERVNELVRWSQDTVSLDTPVGDDGDTNLGDLVADSDAPSPEEIVLTGLERQRIEGLLNHLDDRSAGIMRARYGLEDGREHSLTEVASRFSLSRERIRQLEIQALGRLRELARAEGLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F761</accession>
    <name>F4F761_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, laci family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735573.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29271"/>
    <dbReference type="EnsemblBacteria" id="AEB46925">
        <property type="protein sequence ID" value="AEB46925"/>
        <property type="gene ID" value="VAB18032_29271"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29271"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="OMA" id="TAWFFAQ"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="344" mass="36728" checksum="F0D913778F38C512" modified="2011-06-28" version="1">MTRIDDVARLAGVSTATVSRALRGLPTVSAATRRRVLAAAEQLQYAVSPSASRLAGGRTGAIAVVVPRITRWFFGVVVEAVEDFLHQCGYDLLLHNLGGREQNRQRLLHPANLHKRVDGVMLVATPLRPADLTALTRLDLPGVTVSSGTDVPGWPCVRIDDVAAARLATRHLLDLGHRRIAHISGDPDDELAFTAHLDRRRGYQEALRAAGLRPDPTLDVESGFDIAGGTRATEELLRRGDPPTAIFAACDEMAMGALTALRDAGLRVPQDVSLIGIDDHALSGVLGLSTIAQPAAEQGRLAAEMLIDPLRGRTRAADCGANDLPVILPTRLVVRDSTAPPRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F796</accession>
    <name>F4F796_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10180"/>
    <dbReference type="EnsemblBacteria" id="AEB43154">
        <property type="protein sequence ID" value="AEB43154"/>
        <property type="gene ID" value="VAB18032_10180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10180"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="TTMRMIC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="33254" checksum="1B386C0D56B85000" modified="2011-06-28" version="1">MIAVQQLTKRYGRHTAVDDVSFHCEPGTVTGFLGPNGAGKSTTMRMICGLTPPTSGTATVAGHPYRHLPNPGRTVGVLLDASAQHAGRTGREALALSAATMGVDRRAVGELLDRVGLNGAAARRRVRAYSLGMRQRLGLAHALLGDPAVLVLDEPANGLDPEGIFWMRGLLRDFADRGGTVLLSSHLLREVEAVADRLVVIGGGRVVAQGSKEELLAGSGTLVRARDRAALRDALERAGLPVGDSTDGLLVSADSEAVGLAAAAAGVALTELRPAGAGGLEQLFLTLTAEAATGPTSTRSAETATGPTSARSAAVLPTEEIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7G1</accession>
    <name>F4F7G1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2016" name="J. Am. Chem. Soc." volume="138" first="6095" last="6098">
            <title>The Catalytic Mechanism of a Natural Diels-Alderase Revealed in Molecular Detail.</title>
            <authorList>
                <person name="Byrne M.J."/>
                <person name="Lees N.R."/>
                <person name="Han L.C."/>
                <person name="van der Kamp M.W."/>
                <person name="Mulholland A.J."/>
                <person name="Stach J.E."/>
                <person name="Willis C.L."/>
                <person name="Race P.R."/>
            </authorList>
            <dbReference type="PubMed" id="27140661"/>
            <dbReference type="DOI" id="10.1021/jacs.6b00232"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 2-141</scope>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733060.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="PDB" id="5DYQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.66 A"/>
        <property type="chains" value="A/B/C/D=2-141"/>
    </dbReference>
    <dbReference type="PDB" id="5DYV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=1-141"/>
    </dbReference>
    <dbReference type="PDBsum" id="5DYQ"/>
    <dbReference type="PDBsum" id="5DYV"/>
    <dbReference type="SMR" id="F4F7G1"/>
    <dbReference type="STRING" id="263358.VAB18032_16470"/>
    <dbReference type="EnsemblBacteria" id="AEB44400">
        <property type="protein sequence ID" value="AEB44400"/>
        <property type="gene ID" value="VAB18032_16470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16470"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1824530_0_0_11"/>
    <dbReference type="OMA" id="HALFTRS"/>
    <dbReference type="OrthoDB" id="2007282at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041013">
        <property type="entry name" value="AOC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18678">
        <property type="entry name" value="AOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AOC_like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="5DYQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5DYV"/>
        </source>
    </evidence>
    <sequence length="141" mass="15602" checksum="E231CD5F9EC69E7B" modified="2011-06-28" version="1">MTERLETRPQALLIKVPTEIVVKVVDDVDVAAPAVGQVGKFDDELYDEAGAQIGTSSGNFRIEYVRPTDGGLLTYYQEDITLSDGVIHAEGWADFNDVRTSKWVFYPATGVSGRYLGLTGFRQWRMTGVRKSAEARILLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7G5</accession>
    <name>F4F7G5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SARP family pathway specific transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_16490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733064.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16490"/>
    <dbReference type="EnsemblBacteria" id="AEB44404">
        <property type="protein sequence ID" value="AEB44404"/>
        <property type="gene ID" value="VAB18032_16490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16490"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_0_1_11"/>
    <dbReference type="OMA" id="DICELRV"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="27849" checksum="CCDFF3ECF0B2A08E" modified="2011-06-28" version="1">MRYQLLGALRIADPAPRTITAPKVETLFATLLIRANHTVTTDELIAELWGENPPRHARTALHVYVSQIRKQIPSPRPGAAVLHTKPQGYQMEVDENLVDAVELQRMHALGRSLLVTDPEAALVPLRRAVGLFRGPVLAGIRNGLVVGNFAEWAEEVRVDCLHAIGRAALATNRHRELIGELVQWVEEHPLHEPLREVLMVALTRAGRRAEALAAYQSTRRVLHEELGLEPGEAMRRLQLAILSADVGLVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F898</accession>
    <name>F4F898_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731930.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10705"/>
    <dbReference type="EnsemblBacteria" id="AEB43259">
        <property type="protein sequence ID" value="AEB43259"/>
        <property type="gene ID" value="VAB18032_10705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10705"/>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_229434_0_0_11"/>
    <dbReference type="OrthoDB" id="139382at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2254"/>
            <end position="2283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="2379" mass="253394" checksum="6A322A496CE62223" modified="2011-06-28" version="1">MSQPQQPPADALAGVLRHLSGGTTGATGQANTGGTNIANSGVIERLTVALSAAPPQPSTTAFVSYPESDRDWVEQSLLAALDPLPMQLFYSGGHLSQPDDWEMVYAVMDKASLLIVVGRDGSVVRDRRVRDQVAYWLDNHPDRSGVVLVGQPDSRPEAIDHRLAGLPMVAMPVGEVTAASRAAADDRLVRAIRLTPRAEPVATRDRVVDEDALGPVRDAYLRWVCRTHSVIDTVVAGVSVTMPLAECPPPGPLVRDGSSGRTRSTELDHLRSRARQVAGGGGTTPDSGAEFSVLADRPLPTYLSPTRSIDRLDLSGLPELSPGRLAGTVWRAIVLGEPGSGKSSMVRRLAYDTAARRLADDGERDEVRRLPVLCRAADLAVGLAGAEESAEGLAALAIQLGWAGALPTDPASGDRLPPDELARLARVALRSRRLVLIVDGLDEVPSLADRRSVAAALDVFAASGGVRLDHPARAPGNQTIITSRIAGYYAAALGDRFEQFLIGPLDGDGAAAVVDYWLSGYFALARVPELTQVQRRTEIEQLITGGGAAVRQLAANPYLLVSLVSVVLSGLSGRPGVRGDRWLRVDLYTAMVEHAVRRGGLRFPDVPVDTLIRLQAAVAYQMHDVSRSGLVDRATLTQLCRRARELLGEPAPPVAAEQVDPVIAGIDLLTARGQELYGFRHLTVQEYFAGRWLIDAGTVDAIVTAVGDRLGDPRWLEAVRLALGQLSRVSEPVFAAVVDKLLAGPGRRLAAEMLSHSLADIAGLRRQHLRALVQVAVQTEAELTGTVVTLHPDGARMLEPLLRWTVSVQGDTAPRLLCEALCEHLRDPAPAMAAAAARLIDALRLDDRSVVQALLEAQYRDSADHGWQVTRALLTVLHRRMTAIGGGDPETVRAGLDADQRALVDTMVRAAPPTTAAGSGRRRAGIRAATTIGVRNQMRTALTTEAVLRERVGSDLGWLRVLLCLYGGIPFLDMIHWLRRQDEAVSVFAAPTSEPAERYRAAVLLDTLIRPAIAARGPRPVAFRPEQIAIDSPLTDHLLTWLRAGVPGHDLPDLLAGVLTDRRADPQVRGDALAAWLVLDTGEAQAGATAPFVELVSEEDIATVEAVRRRARWRLGRTDMLLSDALAGLNPLAAGAGLTGDAATDLFRDAFTDVVRALWSVGTPRPDGDSTSRPLSEELALAVCGANDDKEYAVAVTLDVKGRDMVNVAGGLASALADVARTESVAAAGTDDWRLDPLSPPTGDLAEALTVLAGLHPRWGFLRCWCLDRLAEQIIAEGFRTEAACLALEVLVTDPISARRTLDRLGTAAGAPTGGAAEHSDQHEETGDVEAQPGDAPFAGSGLPGDPVALSRLDRSSGRSGSAYAELRGRIRLAALLGDRWTVRVLDEALGGLTDAHQRLRAIELAVGERLVVPGPELLERAVAAARQVDDPAARASALARTARWTDLDTEEGLLREALVALRHAPPDEVARVLSVLPPPTSDETRALRRRCEAVLTFRRQRSIARGDAAGALLSHDRLDRDADTVQAWAALTTAMLCRRGLDLLRDTAGRFTSERAAWSALSDLERRPAALAALRARAAAGVTALRLEKEAVAGIDALLAAEQVDDAVELLAAGRATSAVSRLRRWREHPRADLAGVATLLAIESGELDPPAVARLADLLRSEDDRIRLRTRTAIASVSRGGQGPPRLRASALGAESIVELVRLVCAARDRHPHLHGDLSWALADIVHDAPGVLRSALDLLAGEPAARRRLLVALHHLRLPVLDMLLAELPRLPDEEQMEVLWALQTVAWTPSRFGMEATRLRRAAGAARRCVNESGDGPAAQALRLLGLILPVTGLSVDALVGEALSGDGLAEAACDGLGFLLHRARWEAPELDAAEAVTELWLLARDPHEPIAVAALTALARAGVTIEDDVSIAPDLVLRGLVGAVDPFVVGDQWLADLRRAARFVLHGAPVGEGTDPNPLLALLLDQVVAQLVKQAEAPDRPRWDAGADYLSVLYAVAVQQPAALREAVAGEPRDLPALLLTLLGHEPGWATRSVAGALLAILGDGDAPSLRTLLDMAWDTDAVGERVLGSFRWLDRVTEQGLAELVRATADPFVARAYFAVQMLAALARQGVFGPDEQRTALAAVAGAIRRPDATRHVLLERDGRISSLGTLADACRQAIGWIESDRRLRESEAVHAGVVLPAEGVNGEPVTLRLTGEVPIDEPVRYQIDYLQQTESIELPAALTQRLGAVTAAAAGAKVPLVALVPSATDGPGRGSGSPRATGEQGQGRLAQAAAESSGMPKSSLLLVLGRNMAGEEVYSYLRVSEQQIEDVRAALDSRRPFTPGDYGTVVISGRGKPSTEVIELVGVPDFLIQFNEPTAAASTAADPPAETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8B1</accession>
    <name>F4F8B1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Group 1 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731943.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10770"/>
    <dbReference type="EnsemblBacteria" id="AEB43272">
        <property type="protein sequence ID" value="AEB43272"/>
        <property type="gene ID" value="VAB18032_10770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10770"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_11"/>
    <dbReference type="OMA" id="PCREREP"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="382" mass="41464" checksum="C71386A6CF9CD71C" modified="2011-06-28" version="1">MSSKNSREYDLCVAVNYYSPYVSGLTEVARVLAEGLVERGWRVAVVAVRHDPELPLRESRNGVDVYRSPVVASISRGPVSPGFPALVRRIARRSQVVNLHLPMLEGALITALPLGVPVVSTYHIDLWLPPTLVTRAAMAAVRVSSRITLRRSDAVVVNSDDQAQYSELWPILRSSQRSAIPAPCLDRRGGEPTFRETDGPHIGFLGRIVPDKGLDYLVAAFAEITDPQARLLLGGDYLTVAGGSVIDRIRAAAQRDPRIRILGLLRGQQINDFYASIDAFALPSIAESFGIAQAEAMMCGIPSVTTDLPGGRYPVLATGMGRIVQPRDPVGLRAALLDVLGWDAATRREGAKRAIEEFSVQGCLDRYATLFRAQGARASALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8C2</accession>
    <name>F4F8C2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733124.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16815"/>
    <dbReference type="EnsemblBacteria" id="AEB44467">
        <property type="protein sequence ID" value="AEB44467"/>
        <property type="gene ID" value="VAB18032_16815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16815"/>
    <dbReference type="eggNOG" id="ENOG502ZCMV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096850_0_0_11"/>
    <dbReference type="OMA" id="WFWLTDG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046026">
        <property type="entry name" value="DUF5984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19446">
        <property type="entry name" value="DUF5984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="32079" checksum="73A95B7FAFDADBA2" modified="2011-06-28" version="1">MIRFRFELYPLDEVSPWGRDQPSLHWFGLTEGWYWLETSGQELLRRTRQSDPHPYIDYYLARLWEDLIVLTPEVLEPVPDDLQPFIASHHAQWTCDPLEFVEEPDERRFDDGNADVPDHPVVTAAVWHGEHHLDFGYLRNPPTLRLWRTTCGDRDEITLDWRHEDDGEIGFTADSTVRLSLPTTAYLEAVHILDRELMDAMGQRVEDLEHRGGLPGVDIDLVDLRREHEDRRHWLARNLDRAPKTDWNAVRQGARLLLGDVPTGRHLHGPGNPSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8C9</accession>
    <name>F4F8C9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733131.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16850"/>
    <dbReference type="EnsemblBacteria" id="AEB44474">
        <property type="protein sequence ID" value="AEB44474"/>
        <property type="gene ID" value="VAB18032_16850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16850"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_11"/>
    <dbReference type="OMA" id="GLNHAQP"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="29507" checksum="C3C012FA8196ECC5" modified="2011-06-28" version="1">MTTWFITGASRGFGLEITRQALDRGDNVVATARNPEAVSAALPDHGDRLLAVALDVTDEEQTRAAVSCAVEAFGAIDVLVNNAGRGLLGAVEESSDAEVRAIYDTNVFGLLNVTRAVLPVMRSQRSGRILNVSSLGGFSSSAGFGIYCSTKFAVEGISEAMRAELAGLGIAVTLVEPGYFRTDFLDDRSLRTEGTVIDDYAGTAGAVRGAVPGLNHAQPGDPVKGAAAFLTLADAENPPVRAQLGSDCLQELENKITQLRAESEAWRDLALSTDYDDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8D2</accession>
    <name>F4F8D2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type III restriction protein res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16865"/>
    <dbReference type="EnsemblBacteria" id="AEB44477">
        <property type="protein sequence ID" value="AEB44477"/>
        <property type="gene ID" value="VAB18032_16865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16865"/>
    <dbReference type="eggNOG" id="COG4951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712501_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="16525" checksum="5D6E7D71D664BA0F" modified="2011-06-28" version="1">MEPPGLVSMASPTRDKLALFADRFRARADVYAVRWENARTGAAGWMPAVAGGWRKGMDRRGATHLPCTAEVVAAHLVGDVFMGLYPLMPGNTCHFVVADFDGPTAMLDALAYVKAARANAVPAALEIPVRPRSPLHRRRFRSHRAGRGHGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8I7</accession>
    <name>F4F8I7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_17140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17140"/>
    <dbReference type="EnsemblBacteria" id="AEB44532">
        <property type="protein sequence ID" value="AEB44532"/>
        <property type="gene ID" value="VAB18032_17140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17140"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_2_11"/>
    <dbReference type="OMA" id="CKWILAD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="216"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="418" mass="44416" checksum="1242C4D73F52C44B" modified="2011-06-28" version="1">MRAVLAGLAAIGLALANVALLVVSLLALVLVPVPLLGMALLSWTTTLVRKRADLERRRAAWAGVPVPRPYHPPPERGIAGGWRRFRWIVTDPATWRDLAWLLPGGIVGATLGVISLAVPLYGIMGLTLTPLWIWLGTDWYGYGTVWSIDTFGEGLICLPQGAAILAGGLWVAPWLRRVDAYFARLLLAPTKAAELRLRVAQLTVTRADTVDAQAAELRRIERDLHDGIQARLVSLGMTIGLADELIDRNPAAAHEMLAEAREASSAALVELRHLVRGIHPPVLAERGLDGAVRALALSLPVPITVDVDLPGRLDTPVESAAYFAVAETLTNMVRHSRAHTGSVSLRHADGTLTMVVADDGVGGGDPVSGTGLRGIERRLAAFDGTMALSSPLGGPTVITMELPCALSSPRTTRSSGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Z4</accession>
    <name>F4F8Z4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735722.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30016"/>
    <dbReference type="EnsemblBacteria" id="AEB47074">
        <property type="protein sequence ID" value="AEB47074"/>
        <property type="gene ID" value="VAB18032_30016"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30016"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116681_1_1_11"/>
    <dbReference type="OMA" id="ARDTFAW"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="135" mass="14245" checksum="F731A0251036708F" modified="2011-06-28" version="1">MTQLTGQPTTDDDIVHLTVPADGGYLGVLRTATAGLAARLQFALDEIEDLRIAVDEACAMLLAIAPRGAELDCRFAVTEDALTVEVTVPTVRDARLPAESSFAWKVLTALTTSASATATDGRATISLLTRRASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Z9</accession>
    <name>F4F8Z9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="5" type="ordered locus">VAB18032_30041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735726.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30041"/>
    <dbReference type="EnsemblBacteria" id="AEB47079">
        <property type="protein sequence ID" value="AEB47079"/>
        <property type="gene ID" value="VAB18032_30041"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30041"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044089_2_0_11"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="OrthoDB" id="674332at2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043866">
        <property type="term" value="F:adenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="4">
        <location>
            <begin position="67"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="253" mass="27541" checksum="74AF0929703563E9" modified="2011-06-28" version="1">MSALVSAAGLGLVGTAPTATSGGRRGPEQLRELAERAGRELEGAPALEIARWAAETFGDRFCVTSSMADAVLAHLVSRVAPGVDVVFLDTGLHFPETLAVRDAVARTLPVNVRSIRPRLTVGQQDGEYGPRLFNKSPDECCQLRKVEPLERALAGYDAWAAGLRRDESPTRANTPVVTFDARRGKVKVNPIAAWSQADVDAYIARWNVPVNELFRRGYGSIGCWPCTRRTKAGEDPRAGRWAMFEKTECGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F915</accession>
    <name>F4F915_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730717.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04585"/>
    <dbReference type="EnsemblBacteria" id="AEB42043">
        <property type="protein sequence ID" value="AEB42043"/>
        <property type="gene ID" value="VAB18032_04585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04585"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1474412_0_0_11"/>
    <dbReference type="OMA" id="VLLWCPR"/>
    <dbReference type="OrthoDB" id="1821425at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="20632" checksum="E85CF418CAA91ADF" modified="2011-06-28" version="1">MRGVILYGPPAAGKDTVTTALHDLDARFTLYQRMKVGPGRTTGYRITDAATLDQLHQRGEVVWENHRYGARYVVDRPSLVEQLSVGVPVVHLGQRAAVAAVTAAVSDARWLVVYLWCPRDVAEQRIISRHTGDTAARLRAWDDTEPLAERDLFLNTAEMSPRTAAEVIHRHVLDDIRPAISKSDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F957</accession>
    <name>F4F957_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WecB/TagA/CpsF family glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04795"/>
    <dbReference type="EnsemblBacteria" id="AEB42085">
        <property type="protein sequence ID" value="AEB42085"/>
        <property type="gene ID" value="VAB18032_04795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04795"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063203_2_0_11"/>
    <dbReference type="OMA" id="PWRWRRM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="30297" checksum="0E6A1B80F66ADF81" modified="2011-06-28" version="1">MGPGARRRGPAVSKRNVLGVLVDATDYATATEQVIAAAQERRPMALTALAVHGVMTGVLDPAHNARLNSFDLVTPDGQPVRWALNLLHGAGLTDRVYGPQLTLHVLSRCADEGLPVYLYGSTEQTLARLIPALERMFPALKIAGVEPSKFRAVQPGEDVEIADRIKASGARLVLVGLGCPRQEIFTYAMRPLLDMPLMAVGAAFDYHAGLLRQPPPWMQRAGLEWFWRLGLEPKRLWRRYVILNPAYLGRLFAQKVGLWKARPPAPATERPAGFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F997</accession>
    <name>F4F997_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43291">
        <property type="protein sequence ID" value="AEB43291"/>
        <property type="gene ID" value="VAB18032_10865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10865"/>
    <dbReference type="eggNOG" id="ENOG5032CDM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1721577_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="16399" checksum="F08FB2FAE707722B" modified="2011-06-28" version="1">MVVAEHIEQPPPPLPATEPAEHPPMRPLWLCRRCGQPWPCTQAKLALLADYAGNPVSLRLYLAGCLCDAIDDLHRLSPSVTGSAVDMFDRFLGWPGQLARAYRVTRRSGGGPGRPSGDASPGGRSLPVPPPAVTGRTERSEEGCGLDRDRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9A9</accession>
    <name>F4F9A9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10925"/>
    <dbReference type="EnsemblBacteria" id="AEB43303">
        <property type="protein sequence ID" value="AEB43303"/>
        <property type="gene ID" value="VAB18032_10925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10925"/>
    <dbReference type="eggNOG" id="ENOG5032UIF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123725_0_0_11"/>
    <dbReference type="OMA" id="NLYFFFR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="19603" checksum="2C6BB398598E0309" modified="2011-06-28" version="1">MDIKVWMYLVYLAVSIGLTVWVARTLARNGLVFLEEVFSDERLARAVNNLLVVGFYLLNLGYVTVAMRHSEPIESTSEAMEELSWKIGLVLLVLGALHFFNVFTLNRYRKSRLRQLATAPPLPPAGFLPMQQPHPAAAPGQRPAHPAAYPPVHPAAPPPANPAAPPPANTPTHPPAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9D8</accession>
    <name>F4F9D8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11070"/>
    <dbReference type="EnsemblBacteria" id="AEB43332">
        <property type="protein sequence ID" value="AEB43332"/>
        <property type="gene ID" value="VAB18032_11070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11070"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_2_1_11"/>
    <dbReference type="OMA" id="PFCLVAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="122" mass="13406" checksum="17A2CF69F34F1440" modified="2011-06-28" version="1">MIGRLRSTVIDCPDPRALAGFYAELLGLPLMEEDSEGNGWVVLGGPPGHQPRLAFQRAPDLRPPDWPDPERPQQLHLDVTVDDVEAAERAVLALGARRLPGEGDGFRVYADPVGHPFCLCWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9L4</accession>
    <name>F4F9L4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17450"/>
    <dbReference type="EnsemblBacteria" id="AEB44592">
        <property type="protein sequence ID" value="AEB44592"/>
        <property type="gene ID" value="VAB18032_17450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17450"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_3_11"/>
    <dbReference type="OMA" id="AYWLLKY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313705" evidence="1">
        <location>
            <begin position="28"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="471" mass="50778" checksum="84C976610AC112A1" modified="2011-06-28" version="1">MDRLSAPRRKVQLATAAMLLMATTVAACGDGGDDGATASAPKAPATIPELTKDPLTLSFIWFDWPPAQALEDFANAEYTKERSNVTVKVNTVPNANWHDAMFTQFAARKTDFDIAILDSQHIGEAVTNGNILDITDFVKNNIEVDAYNPYLLAAYGQFPQAETGQRDENASLYGLPLLGDTWTMIYRKDLIGDKPPQTWDEMISVAEKCQADNPGVSGLAFHQANGSDAAAVTYNTVNGVYGGNLWDPKTRKIDGVLNDAAGHEAMDVLVNKMKPLTARGSGNWFIDEVNAAVAQGKACIAFNWIAASGGLLDPKESTLGTTREQILDKLGFATLPSQKTNLVPLGGMGMHVSAYSAEANQVEARNFMKWFQRADVQKKWAAAGGVPSRTDALSSPEFLNAGPFNQVYADSVPRMRDMWNVPEYARLVDIENTNVNAALNGAKNPKAALDDIAKEQQSVLDSSGRKGGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9L5</accession>
    <name>F4F9L5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17455"/>
    <dbReference type="EnsemblBacteria" id="AEB44593">
        <property type="protein sequence ID" value="AEB44593"/>
        <property type="gene ID" value="VAB18032_17455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17455"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_2_11"/>
    <dbReference type="OMA" id="THFHIFR"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="27157" checksum="E44399374C411E9C" modified="2011-06-28" version="1">MDDEAMIARGRRVVTGGGSSGRAGGRLADEVYDTLLGQLMSLRIEPGSRVTIDVLARELGVSQTPIRDALNRMESEGLVVRVPHAGYRIPPQITRSRFEDMLEVRLLLEPAAARRSAERATLAQVAGLRRMLGEMAELEGGDGPAAYGAFGLRDAAFHDLVALSAENQVIRETLARLHSHVHLFRLHRDAQVTHLAMAEHEDVVAAIAARDPDAAAYAMRRHILRSGERFRRLFDELEQTDPVAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9R6</accession>
    <name>F4F9R6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23720"/>
    <dbReference type="EnsemblBacteria" id="AEB45842">
        <property type="protein sequence ID" value="AEB45842"/>
        <property type="gene ID" value="VAB18032_23720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23720"/>
    <dbReference type="eggNOG" id="ENOG503319Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179332_2_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="9296" checksum="B6A407BB57E27D28" modified="2011-06-28" version="1">MATMVREPASPVKDDHYDLLHTLQMSLEHVWKMENYIADAEARGDSELATWFREIQDDHRKMGEQGKKLLKARLQQEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Y9</accession>
    <name>F4F9Y9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding region ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735747.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00080"/>
    <dbReference type="EnsemblBacteria" id="AEB47100">
        <property type="protein sequence ID" value="AEB47100"/>
        <property type="gene ID" value="VAB18032_00080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00080"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042141_0_0_11"/>
    <dbReference type="OMA" id="AWILVED"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045975">
        <property type="entry name" value="DUF5931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19354">
        <property type="entry name" value="DUF5931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5931" evidence="5">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="189"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="289"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="376" mass="39156" checksum="D9EBCFC673AD1109" modified="2011-06-28" version="1">MVTHVPAPGGFEVPLWRAVAVFRVASLAYVCVVVARDADRYAHPLAAGALVLVMAAWTVVTAFGYAAPARRGWPLLLADLGVVVAILLVTPWVMGREALAAGLPTLAIAWLSGPVLAWAVSGGRRRGVTAALVIGGTDLVTRGMVTPTAINGTILMLLAGVVVGHVARLAVRAEQRLQQAVELEAATRERERLARDIHDSVLQVLALVSRRGEHLDGEAGELARLAGEQEAALRALISDAGPRATDGPVDLRELLGRYASATVSLSTPATAVPLPPRVAHELAAATGAALDNVARHGGGRAWVLVEDEDSTVTVSIRDEGPGFAPDRLTEAVAQGRLGVAQAIRGRLTDLGGTATISSVPGSGTEVELTVSRRRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Z1</accession>
    <name>F4F9Z1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="7">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purC</name>
        <name evidence="9" type="ordered locus">VAB18032_00090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735749.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00090"/>
    <dbReference type="EnsemblBacteria" id="AEB47102">
        <property type="protein sequence ID" value="AEB47102"/>
        <property type="gene ID" value="VAB18032_00090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00090"/>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_0_0_11"/>
    <dbReference type="OMA" id="QKARPVM"/>
    <dbReference type="OrthoDB" id="1345271at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="8">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="277" mass="30613" checksum="826AB4BD0F39F3AE" modified="2011-06-28" version="1">MELLHSGKVRDVYADGDDLILVASDRISVYDVVLPTPIPDKGKLLTALSLWWFEQLADLVPHHVISATDVPAEFAGRAIRCRRLEMVPVECVARGFLTGGGLKEYERTGAVSGVELPRGLVEASILPEPIFTPSTKAPMGEHDQPMTFAEVVDKVGAQTAERLRQVTIDVYCRGTELAAQRGILVADTKIELGWAADGTLVLADEVLTPDSSRFWPAESYQPGRAQFSYDKQYVRDWAASSGWNKQEPAPEVPAEVVEATRARYVDVYEKLTGNRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAI6</accession>
    <name>F4FAI6_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732083.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11495"/>
    <dbReference type="EnsemblBacteria" id="AEB43413">
        <property type="protein sequence ID" value="AEB43413"/>
        <property type="gene ID" value="VAB18032_11495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11495"/>
    <dbReference type="eggNOG" id="ENOG5033G9I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182347_1_0_11"/>
    <dbReference type="OMA" id="RMQAEND"/>
    <dbReference type="OrthoDB" id="2079019at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="7056" checksum="02AA6BB8E019F225" modified="2011-06-28" version="1">MAKALFGHVGAAPDRRLLDEVTRLRARVQSLEFEITRLRAENDRLAAAAAEADDLLRLAEPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAW4</accession>
    <name>F4FAW4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24145"/>
    <dbReference type="EnsemblBacteria" id="AEB45927">
        <property type="protein sequence ID" value="AEB45927"/>
        <property type="gene ID" value="VAB18032_24145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24145"/>
    <dbReference type="eggNOG" id="ENOG5032NDB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3009222_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="56" mass="6459" checksum="802F9E01DFC83382" modified="2011-06-28" version="1">MTEPEEDQEKTRKTDQVLFSPDGDPHHTLAEAPQPDEHLSVRFTHDDETEVVDDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB82</accession>
    <name>F4FB82_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="13" type="ordered locus">VAB18032_00715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735872.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00715"/>
    <dbReference type="EnsemblBacteria" id="AEB47227">
        <property type="protein sequence ID" value="AEB47227"/>
        <property type="gene ID" value="VAB18032_00715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00715"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_11"/>
    <dbReference type="OMA" id="PYILINQ"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="547" mass="57477" checksum="0E9AEE43697991F3" modified="2011-06-28" version="1">MAKILSFSDDARHQLEHGVNALANAVKVTLGPRGRNVVLDKKFGAPTITNDGVTIAKEIELTNPYENLGAQLVKEVATKTNDVAGDGTTTATVLAQAMVREGLRNVTAGANPAGLKRGIDAAAAKVSEALLGKAVEVSDKKSVAHVATISAQDSTIGELIAEAMERVGRDGVITVEEGSALQTELDVTEGLQFDKGFISPNFVTDVEAQESVLEDAYILITTQKISAIEELLPLLEKVLQDNKPLLIIAEDVEGQALSTLVVNSIRKTLKVCAVKAPGFGDRRKAMLQDMAILTGAELVAPELGYKLDQVGLEVLGTARRIVVDKENTTIVDGGGQAGEVADRVAQIRKEIEASDSDWDREKLAERLAKLSGGIAVVKVGAATEVEMKERKHRIEDAIAATKAAVEEGTVPGGGAALAQILSVLDDDLGFTGDEKVGVSIVRKALVEPLRWIAQNAGHDGYVVVQKVTEGKWGHGLDAAIGDYVDLAASGIIDPVKVTRNAVTNAASIAGLLLTTESLVVEKPKEPEAAAAGHGHGHGHSHQHGPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBB5</accession>
    <name>F4FBB5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-binding 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_05425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05425"/>
    <dbReference type="EnsemblBacteria" id="AEB42211">
        <property type="protein sequence ID" value="AEB42211"/>
        <property type="gene ID" value="VAB18032_05425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05425"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_11"/>
    <dbReference type="OMA" id="KGVNYPK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="184"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="307" mass="32068" checksum="C95E26F9F5CEBE31" modified="2011-06-28" version="1">MTQRFVVVGAGTMGLGIAYVAAGAGYAVELVELDRARGEAAVERLAQLWERAVQRGKLTAEQAAANRASVTLRAGLGEVAPEPAVIVEAVPERLELKRAVLAEAERLEPALLGSNTSSIAIAELAGELARPERFCGLHFFNPVWAMALLEIVVGPATAAETTEAARALADRLGKDPVVVRDMPGFATSRLGVTLGLEAIRMVADGVASPADIDKAMALGYRHPIGPLELTDLVGLDVRLDIARTLQAAYGDRFAPPPLLVEMVAAGRLGKKSGQGFYQWVDGVRSGGTESAAPTTDPASDAAPGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBC4</accession>
    <name>F4FBC4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05470"/>
    <dbReference type="EnsemblBacteria" id="AEB42220">
        <property type="protein sequence ID" value="AEB42220"/>
        <property type="gene ID" value="VAB18032_05470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05470"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_11"/>
    <dbReference type="OMA" id="RYKTASY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="39641" checksum="E2735199AD49302A" modified="2011-06-28" version="1">MLPEQPVGGDEPIPAVLAAYTRDLVTAVEQTLAEFLDAEVDALATIDPAMGGFAATARDCVLAGGKRVRPTFGYWGWRGAASGDEPLHRVLPALATLELLHTFALVHDDVMDHSATRRGRPTAHVAMAAQHAAAGRCGDSGRFGEAVAVLIGDLCLVWADQLLARAALPASRLLDVRRGYDRMRVETIAGQYLDILGEADPENWSVDRALRVARYKTASYTVQRPLLFGASLAGVDGGTPLTDAYTRYGLAVGEAFQLRDDLLGVYGDPTATGKPAGDDLRTGKPTALLMLARELASPAQRQALDGTGSLPGEPEVARLAEIVFDTGAVDRIERMIDERVQQALDALATVRIDETARTALFGLASAATDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBG0</accession>
    <name>F4FBG0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_05650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730929.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05650"/>
    <dbReference type="EnsemblBacteria" id="AEB42256">
        <property type="protein sequence ID" value="AEB42256"/>
        <property type="gene ID" value="VAB18032_05650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05650"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_11"/>
    <dbReference type="OMA" id="WVWELPG"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="47"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="188" mass="20850" checksum="1B89367EC4DF6430" modified="2011-06-28" version="1">MVEGQDVGSTRWTIHGERVVDGSRRARLSIADVELPDGVRFEQYVIRAPRSAMVAVLDGQGRLLLMRRHRFVFDRWVWELPGGYVDEGEDPTVCAVREVEEETGWRPGAVEPLLAFQPWVATADAENLLFLARSAEHIGAPVDVNEAEQVAWIPLEEARQLVSQGEIVGAGTVIAVLELVAREARGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBT5</accession>
    <name>F4FBT5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_18165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733390.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18165"/>
    <dbReference type="EnsemblBacteria" id="AEB44735">
        <property type="protein sequence ID" value="AEB44735"/>
        <property type="gene ID" value="VAB18032_18165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18165"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_12_0_11"/>
    <dbReference type="OMA" id="EFTELGY"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="85" mass="9355" checksum="597CE8DF07C0C11F" modified="2011-06-28" version="1">MPELTLADLTRILRAAGGEDDPETLQGDILDVPFTDLGYDSLAMLETVSRIEREFDLSLPDDLVPEMPTPRIALDTINSRLRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBT6</accession>
    <name>F4FBT6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-(Acyl-carrier-protein) synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_18170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733391.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18170"/>
    <dbReference type="EnsemblBacteria" id="AEB44736">
        <property type="protein sequence ID" value="AEB44736"/>
        <property type="gene ID" value="VAB18032_18170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18170"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_11"/>
    <dbReference type="OMA" id="TDHMTRL"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="4">
        <location>
            <begin position="251"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="40977" checksum="3588F935A5D2D879" modified="2011-06-28" version="1">MSTAVVTGLGVLAPTGCTVADHWSSVLAGRSALAGITLFDASAYPTRVAGTVAGFAAHEHVPGRLVPQTDRWTHFGLAAAAQALDDAALDPAALPEYEMGVVTASSSGGTEFGQREIEALWRDGPGHVGAYQSIAWFYAATTGQISIRHGMRGPCGVLVTEQAGGLDAIGQARRLVRGGLRTVVTGGTDASLCPYGLVAQLSSRRLSPGTDPARAYVPFDADAAGHVPGEGGGMLIVEEAGAAAERGARRYGVVAGYAATFDPPPGSARPSALGRAITAALADAGLRPGRIGAVFADAAAVPELDRQEAAAIAGVFGPYGVPVTAPKTMTGRLYAGGAALDLVTALLALRDGVIPPTTGVRHPLDELRLDLVCDRPRQADLEHVLVLGRGIGGFNAAVVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBV4</accession>
    <name>F4FBV4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733409.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18260"/>
    <dbReference type="EnsemblBacteria" id="AEB44754">
        <property type="protein sequence ID" value="AEB44754"/>
        <property type="gene ID" value="VAB18032_18260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18260"/>
    <dbReference type="eggNOG" id="COG2350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_7_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="93" mass="10187" checksum="49E8E1D2F4CDA37E" modified="2011-06-28" version="1">MRFEQTWLVTATFTADAAVRREPHRPAHLAYVRHLLADGTALIAGAHADLRASVLVLRAADAAAARALVEHDPYWRNGVWTAIDVVDYLAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBV9</accession>
    <name>F4FBV9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar-ABC transporter transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18285"/>
    <dbReference type="EnsemblBacteria" id="AEB44759">
        <property type="protein sequence ID" value="AEB44759"/>
        <property type="gene ID" value="VAB18032_18285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18285"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OMA" id="LPEYYIW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="325" mass="34627" checksum="C1BA23A53544F838" modified="2011-06-28" version="1">MPIGNTQPSVRPALSGRTDGPAGDTSARRPARRAGSGGGLRAERLAPYILVAPAVLIIVLLRLYPLLLGVNFSFTGDGARNGTAVGIDNYRELLTDPLFRTALGNVGWLVLLLPVAVAIPGLLATFIYLRVPGHRVYRSVYFFPAVLSPVIVGAIFNLLLAFDGPLNAVLGAVGVPPTDWLGNPDIAMFVVVGVHVWATFGMSLVVFLAGFATLDSALLDAARVDGASLPQVIRHVIIPGLSRTIQFVFVTTMIGMLTSMFGLLYVMTSGGPEGSTYLPEYYIWIQQGQMNRPALASAASTVLFVIMLVVGLLQIQLLRRAGKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC09</accession>
    <name>F4FC09_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, PaaX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734659.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24545"/>
    <dbReference type="EnsemblBacteria" id="AEB46007">
        <property type="protein sequence ID" value="AEB46007"/>
        <property type="gene ID" value="VAB18032_24545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24545"/>
    <dbReference type="eggNOG" id="COG3327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067515_1_0_11"/>
    <dbReference type="OMA" id="PRTRAWD"/>
    <dbReference type="OrthoDB" id="1210594at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="2">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="3">
        <location>
            <begin position="193"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="36464" checksum="9C1E4A5DA8B2A9BC" modified="2011-06-28" version="1">MYAEESVDTVRLPRAQAGSSPQHLLATLLGEYLDSSDADLPSTAVIALLREFGISESSARAALSRLVKRGLIARRGDARPPVYHLTPQAIAKHRSRMQHFLNFGARPPQWTGDWVLVSFSIPSSGQALRHAVRRSLSALRFVGLYDSVWIRPGSDAAPVRQALDELLQHVEDARWSVMHVRFDEESGPHGPASAYDLAALAADYSRFVERYAELREAARNGRVDPVAALVARTSAMDSWCKFADSDPDLPQHLLPQPWPRQQARDTFLDVHTALGALAQTRLVEVVTPYWPDAVSWVTHFRASSDPARPEPVRATPTGPPSQADPNRSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC67</accession>
    <name>F4FC67_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_00810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735891.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00810"/>
    <dbReference type="ESTHER" id="verma-f4fc67">
        <property type="family name" value="Duf_1023"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47246">
        <property type="protein sequence ID" value="AEB47246"/>
        <property type="gene ID" value="VAB18032_00810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00810"/>
    <dbReference type="eggNOG" id="COG4099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025057_2_0_11"/>
    <dbReference type="OMA" id="DWHNRNP"/>
    <dbReference type="OrthoDB" id="2018813at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="537" mass="56651" checksum="485D6254ADA17215" modified="2011-06-28" version="1">MTRPGVVRPDQVGYAQLSTADPTRWRATGTAWAGLVGPTRRRATELADDAAALRSQWSGLAATAAEKQVSDLRVELLALAPVAIEIDQVLAEFAARLTVARARLAAAVTLAASVGVLIDRWGRTSPDPSRVPAHRAVQTVAPVTTALRDALDLATAADREAAGRLDQLTADAESGWLSRPPAGRPAPHSDPAEVNRWWNGLSPAQRRWLVGHEPELIGGFDGIPAAGRDQANRLLLEVRRAALVRRWEELLARMPRGPAEMVGLRAVEAALSGLDALTSRLASPDAPRTYLLGLDVGGEGRTVVALGNPDRAANILTHVPGTTSGLHDATDDLGRAARVLSRCADLAPGQETSAVLWLDYDAPDFLHEAAWDRQAHAAGDALHRFQEGLRATHDGPAARQTVLGHSYGSLVVGGAARDHGLAADALVFVGSPGVGVQHAADLGVPAGQVWASRAPDDVIRLARSPGELARHAVLSLSPAAGIIGLLTGDDDKRWFGRDPAEASFGGRSFPSGRYGHSGYWHPDNPALDGMARIVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCJ9</accession>
    <name>F4FCJ9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_06000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730999.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06000"/>
    <dbReference type="EnsemblBacteria" id="AEB42326">
        <property type="protein sequence ID" value="AEB42326"/>
        <property type="gene ID" value="VAB18032_06000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06000"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OMA" id="GEYADRM"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="29137" checksum="03773CA1914B3265" modified="2011-06-28" version="1">MTRPEVPAVVSPAEVPAVEVRGLQVKLDGVPILAGIDLTVRSGEWVTVIGPNGAGKSTLLRAVGGLLPAPDAVRLFGTPLRDLRRRERARVVATVAQSPVVPPGMAVLDYVLLGRNPYIPPLGRESATDLAVVHELLDRLDLGGFHGRELATLSGGERQRVFLARALAQGATLLLLDEPTSALDIGHQQEVLELVDQLRRTEGLTVVATMHDLSIAGEYADRMVLLANGRIAATGTPDQVLTEDLLSHHYRAHVTVIPGPHGPLVLPTRPSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCZ1</accession>
    <name>F4FCZ1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733478.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18605"/>
    <dbReference type="EnsemblBacteria" id="AEB44823">
        <property type="protein sequence ID" value="AEB44823"/>
        <property type="gene ID" value="VAB18032_18605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18605"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_2_11"/>
    <dbReference type="OMA" id="WNNTTVL"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="20133" checksum="84E6FF6F22DA1D17" modified="2011-06-28" version="1">MRTLIVTEFMSLDGVIDSPGGGSHPHAGWTFKDVPMDEAVWEIKAREEQEAGALLIGRVSYDEFAPVWPTMEEFAEYNAMPKYVVSTTLTDPQWHNTTVLRSLDEVAALKQGDGGTILVHGSATLAQGLAAAGLVDRYHLLIFPLLLGGGRRLFAPDGADKQQLTLVEHATYGNGVQLAVYDVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD53</accession>
    <name>F4FD53_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthetase A</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24925"/>
    <dbReference type="EnsemblBacteria" id="AEB46083">
        <property type="protein sequence ID" value="AEB46083"/>
        <property type="gene ID" value="VAB18032_24925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24925"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_2_11"/>
    <dbReference type="OMA" id="KVMSSAI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="102"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="37435" checksum="C1B0E09BF0606BBC" modified="2011-06-28" version="1">MYQAEQTVAVRKAAAYPGLLGEHLIAEKTRAAMAVQQEALYAAREFLRGQGFTELLPPLIGPVTDPGARGAKALDVDFYGHTYKIMTSAILYKQASLRGFPKLFYIAPNIRVEPPETVDTGRHLVEFHQIDVEIAGGTREDAMDTAAGLLTHVVAHVFDTVPDVLRQLGRDPLDFAELLTGKFDSCTHTEAVQRLRDQGHPQSPDAEINWAGEEILSREADRPFFITDYPKGSRGFYDRENPQDPGVLRNFDLIAHGGFGELVSGSEREADYATLVTRMRESGENPAKYDWYLRLMREGLPSSAGFGMGLQRLVRFLTGLDALWQVSAYPKLPGVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDL5</accession>
    <name>F4FDL5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Had-superfamily subfamily ib hydrolase, tigr01490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731051.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06270"/>
    <dbReference type="EnsemblBacteria" id="AEB42378">
        <property type="protein sequence ID" value="AEB42378"/>
        <property type="gene ID" value="VAB18032_06270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06270"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052657_1_0_11"/>
    <dbReference type="OMA" id="DHDQMER"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="268" mass="29462" checksum="B885FDF1DA3D1511" modified="2011-06-28" version="1">MGRSAAFFDLDKTVIAKSSALAFGRPFYRDGLITRRDVVKSAYAQLMFRLGGTDEQTMARTRDYLAALCKGWQVEQVRQIVAETLHELINPYVYAEAAALIEEHQAAGRDVVLVSASGEEMVRPIGVLLGVTDVIATRMAVVDGRYSGEVEFYAAGPSKVEAVRELAAERGYDLDDSYAYSDSYSDRPLLECVGHPTVVNPDRQLRRLAVENAWPVLEFRHPIPLGRRLRERPAVPVAAAAIGVGVGVAIGIAWYGRHRRTRASTTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDZ9</accession>
    <name>F4FDZ9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18830"/>
    <dbReference type="EnsemblBacteria" id="AEB44868">
        <property type="protein sequence ID" value="AEB44868"/>
        <property type="gene ID" value="VAB18032_18830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18830"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057759_1_0_11"/>
    <dbReference type="OMA" id="YDYSFRV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="32302" checksum="B9900101B19BC871" modified="2011-06-28" version="1">MIDGMAGSLFATSDLHVGYAENRQIVDRIEPESADDWLVVAGDVGERFDDIERTLRLLRGRFARVIWAPGNHELWTHASDPVRLRGEHRYRDLVRMCRDIDVLTPEDDYAVWRGPGGPVTIAPLFLLYDYTFRPPGADTKEEALRQAYDKGVVCVDEMVLHPDPYPDREAWCHARVALSERRLAAADPAMPTLLVNHWPLVRQPTEVLWYPEFAQWCGTVLTADWHVRFRAAAVVYGHLHIPRTTYYDGVRFEEVSLGYPREWIRRGPTPDPLRRIFGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE00</accession>
    <name>F4FE00_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_18835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ABC-type transporter activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="327"/>
        </location>
    </feature>
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        <location>
            <begin position="363"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="397"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AEB44869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="597" mass="64183" checksum="CCD8A0BB7405B6C1" modified="2011-06-28" version="1">MEPSPSGRDRGHRTLSAEEKAQARQVSLRRIGRLFTPHRPALAVVTAIIVASSIIAMATPFLLRTVIDRALPEGDTTLLVWLVLGMVAVAAVTAVLGVVQTWISTRVGQQVMHRLRTDVFGHLQRQSLGFFTRTRTGEVQSRITNDIGGMQSVVTSTATAVASNLTTVVATAVAMVALSWQLSLVSLVVLPPAIWLTRRVARMRREITARRQRELADLNVTVEEGLSISGVQLAKTLGTGPALIDRFTASSARLVDLELRSELAGRWRMATMSIIFAAVPAVIYLAAGLPGTAGTLSIGTLVAFTALQSGLFRPLTGLLNVGVSLAASLALFARIFEYLDLPVDVDDPAEPVRLDPARVRGHVRFEDVTFTYPGNDTAALAGINLDVPAGAHLAVVGETGSGKSTLAALISRLYDPTAGRVTIDGVDLRDLRLADLAAIVGVVSQETYLLHSTVRENLRYARPDATDAEIEQAARAAQIHDLITGLPDGYDTMVGSRGHRFSGGEKQRLAIARTLLRDPRILVLDEATSALDTETERAVQRAFDVLAEGRTTITIAHRLSTVRDADQIVVLDHGRIVEAGDHRSLSNRNGRYASLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE01</accession>
    <name>F4FE01_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Transcriptional regulator, marr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44870.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18840"/>
    <dbReference type="EnsemblBacteria" id="AEB44870">
        <property type="protein sequence ID" value="AEB44870"/>
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    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18840"/>
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    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
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        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="144" mass="15947" checksum="B4C4A1827234CCA9" modified="2011-06-28" version="1">MTEPTTGGVNDDESLAETFRAVAARLRRQTREALEPWAVTPSQSRALGVLARLGEARPGTLAEHLRIAPRSATEVIDDLQERGFVARRPDPADRRATLVALTEEGHRVGTEIRAARRAAADRFFGHLDDADRAELTRILRTLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE09</accession>
    <name>F4FE09_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733533.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18880"/>
    <dbReference type="EnsemblBacteria" id="AEB44878">
        <property type="protein sequence ID" value="AEB44878"/>
        <property type="gene ID" value="VAB18032_18880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18880"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="DERQYEH"/>
    <dbReference type="OrthoDB" id="1882650at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="108" mass="11835" checksum="8668D17CFA3A0981" modified="2011-06-28" version="1">MPAGSSPKRERQYEHIKASAKKRGVGEGRAKEIAARTVNKERARAGESRTASRSSLDDVSSGHRGGKRSHSGAQGRTKEQLYNEARKRGIKGRSSMSKEQLEKALSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE77</accession>
    <name>F4FE77_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amylo-alpha-16-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734795.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25225"/>
    <dbReference type="EnsemblBacteria" id="AEB46143">
        <property type="protein sequence ID" value="AEB46143"/>
        <property type="gene ID" value="VAB18032_25225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25225"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026835_0_0_11"/>
    <dbReference type="OMA" id="QGTVWPW"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024742">
        <property type="entry name" value="Glycogen_debranch_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="PTHR10569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12439">
        <property type="entry name" value="GDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="279"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="644" mass="68690" checksum="AFFD7255B1DC0A8C" modified="2011-06-28" version="1">MIEIRFGSQVCGELTSAASREWLVPDGLGGYAMGTVAGLRTRRYHGLLVVPGETPASRKVGLASLDPAVLLPSGARVRLGAHEWASGDVDPRGFELLERFDLTDGLPRWRWRIGDVVIERELAMLPGRSCVAVVHRLVGGGPVELELAAACTWRDAHGERRADGPPLRMDPVDGGAVIEGAYRLSGPGWTPQGHWWRGAYHREEAARGLHPEEDLWYAGQFRDTLRQPGDTVSVLAWAHDPAPAPPPATEVVAAARRRNREVVASAKPADDVEATLALAADAFVVRTNDAAVDVVAGYPWFGAWSRDTMISYEGLFLCTGRADLGRELLRSYAATLSEGMLANTADTGRVEYNTVDGTLWFLHAVSRHVTVTGDTDLGDELLPALRGVVDAHLAGTRYGIAVDPADGLLTSGAPGAALTWMDARVYGVPVTPRHGKPVEVNALWINGVAGVAELAELAGQDADGLHRLHEQAVKAFRQRFPAPAGWLHDVLDAPAPAYPLGGAAFHDDDLLRPNQLLAWSLPNAPLAPDPRAVGLVGAALLTPLGPRSLSPECPGYLGGHRGGPAERDGAYHQGTVWPWLIGPYADAARRAGLPVGELFVGLEAHLSEYGLGSVSETADGSAPHTATGCPFQAWSVAELLRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE84</accession>
    <name>F4FE84_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25260"/>
    <dbReference type="EnsemblBacteria" id="AEB46150">
        <property type="protein sequence ID" value="AEB46150"/>
        <property type="gene ID" value="VAB18032_25260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25260"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_7_0_11"/>
    <dbReference type="OMA" id="MTRHHHL"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="24592" checksum="47063FE9257E9E5E" modified="2011-06-28" version="1">MTVSNHDLLVRPATTADAGPLIGVLAEAFHEGPLADWLIPDPADRRTVYYRYFKDAVYHGLEHGQVYTTGDQTAVAIWYPRLEPAPVDTRSRLATLEHIAGPYAPKFVLLEEMFDAFHPDEPHHYLAYLAVDPTRQNQGIGAALLADQHRRLDQLGLPAYLEASNMRNRRLYLRLGYHAGPTIVLPTQGPVIWRMWRGAPTSGGRSPFPRTRPHRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE88</accession>
    <name>F4FE88_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734806.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25280"/>
    <dbReference type="EnsemblBacteria" id="AEB46154">
        <property type="protein sequence ID" value="AEB46154"/>
        <property type="gene ID" value="VAB18032_25280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25280"/>
    <dbReference type="eggNOG" id="ENOG5032JW1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2468178_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="88" mass="9849" checksum="0E9409005C4D9236" modified="2011-06-28" version="1">MGRAVPEVAAGTLLRLDPGDWSYGRDLVPGTAVAVTVVCVRDLPNRADEWVWVLGHRPECDYPHVDRHPPCMEVRVKVTALHDQRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEB6</accession>
    <name>F4FEB6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF subfamily RNA polymerase sigma-24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_25420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734834.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25420"/>
    <dbReference type="EnsemblBacteria" id="AEB46182">
        <property type="protein sequence ID" value="AEB46182"/>
        <property type="gene ID" value="VAB18032_25420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25420"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_1_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="31226" checksum="AF7D1AA5A5B5C9FF" modified="2011-06-28" version="1">MTEEEQLAAQFDSHRCYLHALAYRMVGSAADADDAVQEAWLRLARTGGDEIEHLRGWLTTVITRICLDALRKRRVRGEQPLEFELGSLPWEAVTGPRMDPEEEAVLAESVGLALYVVMDALTPAERVSFVLHDVFEIPFESIAAILGRSTAATKMLASRARGRLRLGVPPAGSQSAARDIVEAFFAAAGRGDVAALLAVLAPDVEMRARGPELNVVVRGASVVAGRATMFARPDARVHPAIVDGVPGVLVTVERRPVTVMAFTVTGGVITAIRTLTAPSWLAQIVPSWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEE4</accession>
    <name>F4FEE4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF subfamily RNA polymerase sigma-24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_25560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734862.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25560"/>
    <dbReference type="EnsemblBacteria" id="AEB46210">
        <property type="protein sequence ID" value="AEB46210"/>
        <property type="gene ID" value="VAB18032_25560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25560"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_0_11"/>
    <dbReference type="OMA" id="QQIFHRA"/>
    <dbReference type="OrthoDB" id="1335404at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="34020" checksum="01C968096305F1BE" modified="2011-06-28" version="1">MSLSAHDLDLFEQSRARLEAVAYRLLGSAGDAEDMVQETFLRWQAADRAGVEQPAAWLTKVLTNLCLNQLTSARARRESYVGMWLPEPLLAGDRMLGPVDTVEQRESVSLAVLTLMERLSPNERAVYVLRTAFGYPHAEIAEILDLTESNCQQLYRRARQHVAAGRARVEVDEATARTIVAEFLAAASSGETARLVELLTDDVMSTGDGGGKIPARGTPIVGAVAVARFLRGVFRATDLRRQVLGGAATLYAEIVNGVPAVLVVVADRVVGVLSLEMTAEGVSDIHAQANPDKLDRVTRLWSASARSAPVVDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEU8</accession>
    <name>F4FEU8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YCII--like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06840"/>
    <dbReference type="EnsemblBacteria" id="AEB42492">
        <property type="protein sequence ID" value="AEB42492"/>
        <property type="gene ID" value="VAB18032_06840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06840"/>
    <dbReference type="eggNOG" id="COG3795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130902_0_1_11"/>
    <dbReference type="OMA" id="MLLVHET"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="15536" checksum="4997D27D798D3AB9" modified="2011-06-28" version="1">MAPPQQHDPLKSVKEEIDMRYLALLKAIQPDTPAPPELMAAIMKLGEEATSAGVLLDQGGLLPSAAGWRVDVSGGKLAVTDGPFTEAKEIISYAVYEVRDREEAVEWTSRFMKLHRDMWPGWSGETEVRKVFGPEDFPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFA9</accession>
    <name>F4FFA9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19560"/>
    <dbReference type="EnsemblBacteria" id="AEB45014">
        <property type="protein sequence ID" value="AEB45014"/>
        <property type="gene ID" value="VAB18032_19560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19560"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_3_0_11"/>
    <dbReference type="OMA" id="VWNGFLV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="354" mass="36685" checksum="F3FD3967990870CB" modified="2011-06-28" version="1">MNERLRSMASHRLFWPVAVLVVMLAVNTIYRPGFLAVEVNNGHLYGTPIDILRLSAPLILVGLGMTLVISTGGIDLSVGSICAISGAIACLHISQAPDQNSLVTVFTALAMALGAALVLGAWNGVLVSVIGIQPIIATLILMVAGRGLAQLVTEGQIITINSGPYRAIGLGHLLTLPLAIFIALGAALLVAALTRRTALGMIIESVGGNREASRLAGIRSARMVFLVYVVSAACAAVAGFMMTANVSSADGNNAGLWVELDAILAVVIGGTSLAGGRFYLSGTILGALIIQTLTTTVYAMNISPQTALLFKAVVVIAVCLIQAPEFRAKLGRRRRGGPASPTSTPQPQKEEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFH7</accession>
    <name>F4FFH7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine exporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_25905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734930.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25905"/>
    <dbReference type="EnsemblBacteria" id="AEB46279">
        <property type="protein sequence ID" value="AEB46279"/>
        <property type="gene ID" value="VAB18032_25905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25905"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087840_2_0_11"/>
    <dbReference type="OMA" id="GCYAVVA"/>
    <dbReference type="OrthoDB" id="2025332at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="21423" checksum="C201C93F4CBC4207" modified="2011-06-28" version="1">MSTVVTGAFLAGVVAGYGVAIPVGAIAVLILGLAARTSFRVGASAALGVATADGIYAGVAAFGGAVVAGWLAPFATPLRLVAAAVLLGLAGYGAWRALRPRGSADPAAGVGRAARRGLDTPIRAFAGILALTLLNPATVVYFTALVLGRVELGGSGFALATLFTLGVFLASASWQLLIAAGGTMVGRVLTGVRGRLVTALSSSAIIAALAVAMLLNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFI4</accession>
    <name>F4FFI4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734937.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25940"/>
    <dbReference type="EnsemblBacteria" id="AEB46286">
        <property type="protein sequence ID" value="AEB46286"/>
        <property type="gene ID" value="VAB18032_25940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25940"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_11"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="141"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="476" mass="52863" checksum="D21EB4C11C6A35A8" modified="2011-06-28" version="1">MTEQIVQPLTQEEQLAALGNYEYGWADPDVAGAVAQRGLNEAVVRDISAKKNEPAWMLDLRLKGLRLFERKPMPAWGADLTGIDFDNIKYFVRSTEKQATSWEDLPEDIKNTYDKLGIPEAEKQRLVAGVAAQYESEVVYHKIREDLEEQGVVFLDTDTALKEHEDIFKEYFGTVIPVGDNKFAALNTSVWSGGSFIYVPKGVQVEIPLQAYFRINTENMGQFERTLIIVDEGAYVHYVEGCTAPIYSSDSLHSAVVEIIVKKNARCRYTTIQNWSNNVYNLVTKRAVCHEGATMEWIDGNIGSKVTMKYPAVYMTGEHAKGEVLSVAMAGEGQHQDAGAKMVHAAPHTSSTIVSKSIARGGGRTSYRGLVQVLEGSHSSASTVKCDALLVDTISRSDTYPYVDIREDDVSMGHEATVSKVSEDQLFYLMSRGLSEDEAMAMIVRGFIEPIAKELPMEYALELNRLIELQMEGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFX2</accession>
    <name>F4FFX2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731225.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07140"/>
    <dbReference type="EnsemblBacteria" id="AEB42552">
        <property type="protein sequence ID" value="AEB42552"/>
        <property type="gene ID" value="VAB18032_07140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07140"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="246" mass="25943" checksum="CF43919132C90A15" modified="2011-06-28" version="1">MSERPLALVTGASRGIGRAVAVRLAEQGYGVACCYSRPSEAAEKTEAAVAATGVPSYFAPCDVADDAAVDAFIAEAEGRLGPIGRLVNNAGITRDSPLVLARRPDWEAVLDINLGGTWNFCRAMSFRFMKRRAGVIVNLSSIAGIRGNVGQTAYAASKAGIIGLSRSLAKELAPYGVRVNVVAPGFIETDMTDALDAKARERALGMIGLRRFGRPEDVAGIVDFLLSDQADYVTGQVFQVDGGMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFX8</accession>
    <name>F4FFX8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_07170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731231.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07170"/>
    <dbReference type="EnsemblBacteria" id="AEB42558">
        <property type="protein sequence ID" value="AEB42558"/>
        <property type="gene ID" value="VAB18032_07170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07170"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_0_11"/>
    <dbReference type="OMA" id="MTGHTSG"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="37806" checksum="7D64E9ED72264F96" modified="2011-06-28" version="1">MATLIAASSLRTCLGDGAGTFAALLDGRSGVGPLRHPLTGQLNVTAGYQIDEPAPDVALRAGTWLRECVDEALTRSAVDPARSRVVALVGTGLRELAAVEELAFSGTATNPSRLHFGPAVRDAAPGLAEVVTIANACSAGGHALALAQDLIETGEADAVVVGAADTMTASMLAMIGKVTPEPTTQVRPFDRDRTGVLLGEGAAALVLVGEDWTGPAVGRLLATGLSCDAVHETAPDVDGIGRAMHDAWSRAERDPDEVNLVVAHGTGTALNDPTECVALQRCLPRPAAPLVTAVKGAIGHLSGAAALANLDVALRCLASGTVPPVVGLANPLPEGDGLTFVRDARTQRDVTLAQVNAFGFGGVNAVTLVEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG24</accession>
    <name>F4FG24_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43768">
        <property type="protein sequence ID" value="AEB43768"/>
        <property type="gene ID" value="VAB18032_13280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13280"/>
    <dbReference type="HOGENOM" id="CLU_3359101_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="36" mass="4129" checksum="CC15228B4D330B79" modified="2011-06-28" version="1">MKHMQEGAAHLRVPFDDDDLSFTHPDVIVHPIAIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGE5</accession>
    <name>F4FGE5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733738.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19905"/>
    <dbReference type="EnsemblBacteria" id="AEB45083">
        <property type="protein sequence ID" value="AEB45083"/>
        <property type="gene ID" value="VAB18032_19905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19905"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="RMDMARI"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="36363" checksum="762CC9ADA50ECCA0" modified="2011-06-28" version="1">MKPTLRAVAEAVGVSRSTVSNAYSRPDQLSTELRRRILDAAREMGYPGPDPTARSLRRGYVGAIGVLFTSRLSYAFTDPFATQFLTGVAQAAERHGSSLLLVPLPADAAGARKAVENAAVDGFCVYCGGDEEGEIVDAIRGRGLPFVTTSARPRAEDRWVGIDERAAARSVAEHLTGLGHRRVALLADSVLPDAAPGPVRVGDLADVPHPTTRERLAGFADAFAAVGVDWSQLTILSAADNSRPAGAAAVGAPDALPEPITAVLACADVLALGALDTLREAGRHLAVTGFDDIAEAAPVGLTTVRQPGVEKGRRAAELLLDPPVDTDAHQILLPTTLVVRTSAGPAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGK8</accession>
    <name>F4FGK8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26225"/>
    <dbReference type="EnsemblBacteria" id="AEB46343">
        <property type="protein sequence ID" value="AEB46343"/>
        <property type="gene ID" value="VAB18032_26225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26225"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_10_5_11"/>
    <dbReference type="OMA" id="HYDAHGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="6808" checksum="5F9CD416225DA192" modified="2011-06-28" version="1">MRIGELARATGSTPRALRHYEQHGLIESRRAANGYRCYDASTVTRVRNIRHLLAAALDGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGT4</accession>
    <name>F4FGT4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736227.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02550"/>
    <dbReference type="EnsemblBacteria" id="AEB47594">
        <property type="protein sequence ID" value="AEB47594"/>
        <property type="gene ID" value="VAB18032_02550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02550"/>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_1_1_11"/>
    <dbReference type="OMA" id="DPFPVKG"/>
    <dbReference type="OrthoDB" id="402639at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="36"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="202"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="401" mass="44244" checksum="2678D8B976212A8F" modified="2011-06-28" version="1">MTQAIDRPQSTDDVDVDALVGAVDHDIARDPFPVKGLDHVHFLVGNAKQAAHYYSTAFGMTCVAYRGPEQGHRDHAQYVLTSGSARFVLTGVVRPDADGAEHVAKHSDGVSDIALEVPDVDAAYAHATAQGATGLLEPHDVSDEHGTVRMAAIAAYGDTRHTLVDRSRYTGPFLPGFVARGPIVDRQPMIDAGIQPKRFFQAVDHVVGNVELGRMDEWVEFYKRVMGFTNMAEFIGDDIATDYSALMSKVVANGTRKVKFPLNEPAIARKKSQIDEYLEFYQGPGAQHIAVATNDILASVDAMRAAGVDFLDTPDSYYDDPELRARIGEVRVPIEELKARKILVDRDEDGYLLQIFTKPVQDRPTVFFELIERHGSLGFGKGNFKALFEAIEREQEKRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH27</accession>
    <name>F4FH27_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731314.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07605"/>
    <dbReference type="EnsemblBacteria" id="AEB42641">
        <property type="protein sequence ID" value="AEB42641"/>
        <property type="gene ID" value="VAB18032_07605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07605"/>
    <dbReference type="eggNOG" id="ENOG5031ZTV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1650188_0_0_11"/>
    <dbReference type="OMA" id="HETYARD"/>
    <dbReference type="OrthoDB" id="2120938at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="160" mass="17988" checksum="827B7056BFB2DC0C" modified="2011-06-28" version="1">MTARTQEEIVTRIRALRAHRRDIFGFREEVLVEALDLDHARQLLGPGTPGGWTPRVDHETYARDYLRFAIGKIIDHRGNSASRSVDKLGELAWLLGRDDIVRAMDHTSYPMYGAPTVKAFADGFGWPFLDDLDSDDQRALARMADGQQCDPQGCQRGCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHC7</accession>
    <name>F4FHC7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13965"/>
    <dbReference type="EnsemblBacteria" id="AEB43905">
        <property type="protein sequence ID" value="AEB43905"/>
        <property type="gene ID" value="VAB18032_13965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13965"/>
    <dbReference type="eggNOG" id="ENOG502ZP6E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936722_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="89"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="32357" checksum="CFC3EBAE218452CA" modified="2011-06-28" version="1">MDSKMSRLRSVLRHAYYQSGVRRAHIAAHRAALRARSGAIRNGVGVVLHADPADDRGTLLAMKRGILDRRTVATWRRLVAEERPSVAIDVGANYGEVAFSTRYPGLRELHLVEPNPAVLRWLKETVQGVDGDFPAVVLHTGAASAAAGRARLSFDAAYSGTASLTDARLGIESNHRAGGQRSDAAGAGFEVECFRIDERVSLADDDTLLFKVDVEGHELAVLTGMSGLLDGRRAVGICEVQHADEELIGYLCDTFDVHLLLRGEESRVDVRQLRTALARARETGWGELGKDVVLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHF2</accession>
    <name>F4FHF2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spore germination protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20110"/>
    <dbReference type="EnsemblBacteria" id="AEB45124">
        <property type="protein sequence ID" value="AEB45124"/>
        <property type="gene ID" value="VAB18032_20110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20110"/>
    <dbReference type="eggNOG" id="COG5401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073064_0_0_11"/>
    <dbReference type="OMA" id="WGHVGLY"/>
    <dbReference type="OrthoDB" id="2045632at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018911">
        <property type="entry name" value="Gmad2_Ig-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10648">
        <property type="entry name" value="Gmad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307902" evidence="4">
        <location>
            <begin position="44"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="5">
        <location>
            <begin position="121"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="31286" checksum="EE6862CD7B86F939" modified="2011-06-28" version="1">MSRHPVGTTARRRSAGIAVVVLVLAVGCAPSRSGSLGPAPSVAAPTTGVPTTTGAVPGGPATVASSAATAAPAAGSSAPPPPSTGPVASSRPANLTLELWYVRDGRLVPTRRTRPATVATSRLALTELVAGPNPAEASTGLVTLLPAAEVSRIEAGVATVRLPEALDPGTARLREAQVVYTLTQFPTVRQVAFGTAAPAGRVDYADLLPAIVVTHPVIGDRVSSPVTVSGSADVFEATVSVRVRDAAGRQLATAFTTATCGTGCRGGYRVTVGYRLDREQPGTIEAYEVSAVDGSPTKLVSVPVTLAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHV5</accession>
    <name>F4FHV5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736280.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02820"/>
    <dbReference type="EnsemblBacteria" id="AEB47648">
        <property type="protein sequence ID" value="AEB47648"/>
        <property type="gene ID" value="VAB18032_02820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02820"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_424420_0_0_11"/>
    <dbReference type="OMA" id="TMWGWAD"/>
    <dbReference type="OrthoDB" id="744747at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313080" evidence="3">
        <location>
            <begin position="36"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="646" mass="69928" checksum="AE8F10FD6ABF65E3" modified="2011-06-28" version="1">MARARARITALLLAIGVLAGATISWPGLTATPAYAAPVAYQAPTDLCTTEEWQADFRACVAKLHQVAESEATCLNPPTPTAPDSGIAGWFASRPEASKLAGPKGYYSDYGYAGYSYTTYKIETGCATTLLHPDYKFTNTIANGEFMIATAIIGASNALRERAWDPGTMWGWADPLVDQATKAIYQKVFSVFGIITLCVVGLYLLWRSRQSDMSSAMTTAGWALVVMVAVTALAAWPVKSANLADGALISTLGVVHDAVGPASKDVPPDRCAMPNPDACTDKRPPAVRASDTATEGMLYRNWLRGVLGSADSETARKYGAALYDAKSLSWGEAERIRSNPELREATINAKKQQWMTVAAQIEREDPEAYEYLQGVRDMDRVGAGFIAVLAALLFAMFDLTASLLVLLGFLIFRWAVIAAPILGTIGLLRPASAGLRRLGNAVVAALFNIAIFGTGAAIYLFAVDLIMSTPTLPGWLQVVLVWLCGVVGWLLLRPYRRITQLGGKDSSEAVSSAGSWHRRFFRDMRTAARLDVAEPGGTTEPAMGRRRTVMVEQPKVRPEARPDPVPSGAPPAGERSESRGASDDRGKSEEQPRPEKQPVAPRPRRRQPATWTEPDVPEENPSFAIYRPGSAERTPEKPAPRIRSEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI15</accession>
    <name>F4FI15_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736340.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03120"/>
    <dbReference type="EnsemblBacteria" id="AEB47708">
        <property type="protein sequence ID" value="AEB47708"/>
        <property type="gene ID" value="VAB18032_03120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03120"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_4_2_11"/>
    <dbReference type="OMA" id="YGVTLMT"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="29879" checksum="4857DC3858A7D7EF" modified="2011-06-28" version="1">MGDATTTPGAGAPASGGRPPARYRQIAADLASRIHQGEYAPGEALPAQRELSAHYGVTLMTLRQALQQLSDEGLIVQQAGRGTYVTPVQAAYRVDTLRSFTEDLREQGHEVVTQVLSSGLRRPPAWVADRLAGGDGERTLRLERLRLLNGRPAIHQVSWVRSPQGAAIRERDFVTTSLYAALADCGVAILRASERIVPGVLSAPVAGHLRQPVGSPVFVSERTTVALDGTAVVVDRAVIVGNAMEIRAERAATRLSVRWGAVHSPAASGDERQAPQAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI33</accession>
    <name>F4FI33_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713119.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30169"/>
    <dbReference type="EnsemblBacteria" id="AEB47997">
        <property type="protein sequence ID" value="AEB47997"/>
        <property type="gene ID" value="VAB18032_30169"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30169"/>
    <dbReference type="eggNOG" id="ENOG5032HCK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1730651_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="14976" checksum="F8276C28D2375D8F" modified="2011-06-28" version="1">MTSSVLVLLGVVYIVLAVVFAFTPRLRVLVGLMVGGLMAGAVVSQVNKWLASGIGKIAGPIGDWIGQDTKEVAVAIPSALGLALGIVVVVFLRGKGTGKSAIGGKGAVGGKGAAGGGGGFKKHLPHIALACALLLPMVLGGLGETIRDVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F130</accession>
    <name>F4F130_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731357.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07830"/>
    <dbReference type="EnsemblBacteria" id="AEB42684">
        <property type="protein sequence ID" value="AEB42684"/>
        <property type="gene ID" value="VAB18032_07830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07830"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153068_0_0_11"/>
    <dbReference type="OMA" id="WVRIVLH"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="137" mass="15697" checksum="2A5F172DFBA36EBB" modified="2011-06-28" version="1">MFRDEDLALLARPLYAFLTVAPRGDRWPAPRPVWFEVTDDGDLQMFSLPDAPKLERLRERPRASVVVAAPTGEPEHWVSVEGPVTLHDDGGVELATRLAERYYDMSDPKRQILVDEWRSGGVVRIVLRPERVNRFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F138</accession>
    <name>F4F138_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731365.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07870"/>
    <dbReference type="EnsemblBacteria" id="AEB42692">
        <property type="protein sequence ID" value="AEB42692"/>
        <property type="gene ID" value="VAB18032_07870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07870"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_4_11"/>
    <dbReference type="OMA" id="NQGCTFM"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="18674" checksum="BE57BCD6205553E9" modified="2011-06-28" version="1">MYVQTPEFARYAERIAQVTDVTSRLNALPFSDTEARAELLAVVFGAPLPESVTIYPPFFTEYGLNTRFGKNVFVNQGCTFMDHGGIRIGDNVMIAPKVSLITGGHPLPLVQRREYVASAPIVIEDDVWIGAAAVVTQGVTIGAGSVVAAGAVVTRDVPARTLVAGVPARMVKTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F184</accession>
    <name>F4F184_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ordered locus">VAB18032_14040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732587.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14040"/>
    <dbReference type="EnsemblBacteria" id="AEB43920">
        <property type="protein sequence ID" value="AEB43920"/>
        <property type="gene ID" value="VAB18032_14040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14040"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_7_0_11"/>
    <dbReference type="OMA" id="WRRIKVP"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="44"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="510"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="645" mass="71753" checksum="D8850E3C99493665" modified="2011-06-28" version="1">MDLYIEGDPVADTRAPDGPIESRWERRRFEAKLVNPANRRKMTVIVVGTGLAGGSAAATLAEQGYQVKSYCYQDSPRRAHSIAAQGGINAAKNYRNDGDSVHRLFYDTVKGGDFRSRESNVHRLAEVSVNIIDQCVAQGVPFAREYGGLLDTRSFGGAQVQRTFYARGQTGQQLLLGAYQALERQIGLGNVEMNARHEMLELIVVDGKARGIVVRDLVTGEITSEFADAVVLASGGYGNVFYLSTNAKGCNVTATWRAHRKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRVWVPKAKGDDRAPRDIPEDERDYYLERIYPSFGNLVPRDIASRAAKNVCDEGRGVGPTKLGVYLDFADAIDRLGRKAIEAKYGNLFEMYERITGEDPYEVPMRIYPAVHYTMGGLWVDYDLQSTIPGLFVIGEANFSDHGANRLGASALMQGLADGYFVLPNTIANYLAAGPFEKIDGSHPAAIEARRNVEDRLQRLLAVNGDRTVDSFHRELGQIMWEHCGMERSEAGLRKAIDEIRALREEFWQRVRIVGDADGLNQSLEKAGRVADFFELAELMCIDALHREESCGGHFRAEHQTPDGEAQRDDDNFAYVAAWEFTATGEPSVLHKEDLKFEYVHPTQRSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F199</accession>
    <name>F4F199_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732602.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14115"/>
    <dbReference type="EnsemblBacteria" id="AEB43935">
        <property type="protein sequence ID" value="AEB43935"/>
        <property type="gene ID" value="VAB18032_14115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14115"/>
    <dbReference type="eggNOG" id="COG1938">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055821_0_0_11"/>
    <dbReference type="OMA" id="MGVPHTR"/>
    <dbReference type="OrthoDB" id="605198at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="33549" checksum="80C694705EB5DED8" modified="2011-06-28" version="1">MLDPHELYELTDDLPDLGQPVLIQALTGFVDAGNASRLAREQLLTSLESRPIARFDLDQLFDYRSRRPVMTFVEDHWESYDTPELELHLLHDDDETPFLLLTGPEPDLQWERFVAAVAGLATRLDVRLTVGLNAIPMAVPHTRPAGVTAHATRRELIVGYEPWLQRVQVPGSVGHLLEFRLGEAGRDALGFAAHVPHYVAQAEYPAAAEVLLASVSRSTGLLLPRDGLRSAAEAVRVEIDRQVAQSEEAATLVQALEEQYDAYARGREGKNLLAAENGPLPTAEELGAELERFLAEQTRPNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1F2</accession>
    <name>F4F1F2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_14380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732655.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14380"/>
    <dbReference type="EnsemblBacteria" id="AEB43988">
        <property type="protein sequence ID" value="AEB43988"/>
        <property type="gene ID" value="VAB18032_14380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14380"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_0_11"/>
    <dbReference type="OMA" id="MPGWLHG"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="9"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="254" mass="26849" checksum="E96E5A12180EEC37" modified="2011-06-28" version="1">MSELAVRGTQTAVMISRCVRLSRRNVDALLTSLVLPVLLMLLFVYLFGGAIETGSAYVTYVVPGVLLLCAGFGAAGTAVSVTTDLTEGMIERLRTMDVGATSILAGHVVASVARNLVATTLVLAVAVAIGFRPAVAPLRWLAAAGLLVLFVLAVSWLSAAFGLLARTPEAANGYTFLVMFLPYPSSAFVPVETMPRWLRGFAEHQPVTPVIESLRGLLLDTPVGSAPVRALAWFLGILALGVVLSAVLFRRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1H9</accession>
    <name>F4F1H9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733862.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20540"/>
    <dbReference type="EnsemblBacteria" id="AEB45208">
        <property type="protein sequence ID" value="AEB45208"/>
        <property type="gene ID" value="VAB18032_20540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20540"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013835_0_0_11"/>
    <dbReference type="OMA" id="LGAWWPA"/>
    <dbReference type="OrthoDB" id="1592326at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="903" mass="94421" checksum="339D03E254B05A31" modified="2011-06-28" version="1">MVRRIGAYGAQVGLLAVLGLVAAVLLTAMPRLANGYADRSLHADVARLPHLVRDVSLAVEQRLDQQRPDEAKPAAAGEANLERFAAALPQPLPSLVDRRWYAAVLDEQNLSATGDDPPMDGGAAKKIGLRAQTGLQDSAVLTAGRWPDTEAGGSAEVAVSTAVAEVLSLRPGSRLRFTGASPANQASAQVVGVFNARDAGDPIWDDLTLGLNPIVPVVDGEPYLAMAVTDWAGIDTVVAGSGVPVSYQWRYRLDERRLDTATLETVVTALGDTRRTEWLPRSTVHTSLDVALVRFVDQLHAVQALLAIAQTGLVASLLGLILLAARLTVQRRRDELALLRARGASLAAIGRRTLAEALPVQPVAVLLGWLIATRVPGRSEGTPWGVLLLAVLTTAVVPVLAMLSQRRAALTAGRVDLVRQRPSVRRLVLEAGVLVLAGLGVVLLRRRGLDPAGGVDAYLSSVPVLVAVAAALVAIRLLPWPLRLVGRLTGRARGALLFLGVARAGRGAPVALGPLAVLIVAVSTGVFGGVVTTTVAAARDRAATLTVPADAWLTGWAFSPDAADELNRVPGVQAVARVSVESSRRLLSEAGPQARALGQARVLVVDAPAFAEVVARSGVDVQVPAALRSAARGDGPVPAVVSPTLAAELGDTAVADVQSRWYEFRVAAVADSFPGVGLGVDRFVVLPWQALPEYEFTPIIPNRYLIAGDGVDEAKLLEVADATQRRRQSEVLGREVTRTQLPATLETRQAYRDGLERTGANEVLTLAFTAGAAGGAALAVLAVGFAVVADAAGRGRMLSRLRTMGLSAAHGRRLLVHELVPLVVVAAVTGAAVGIALPRLLGPTLGLAQFAPGVPMRDHLDPLVVGGVLALVLLGLLAGLLVENLVNRRMRLGEALRLGEGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1P1</accession>
    <name>F4F1P1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_26966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735117.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26966"/>
    <dbReference type="EnsemblBacteria" id="AEB46466">
        <property type="protein sequence ID" value="AEB46466"/>
        <property type="gene ID" value="VAB18032_26966"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26966"/>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_0_0_11"/>
    <dbReference type="OMA" id="EMHPQAR"/>
    <dbReference type="OrthoDB" id="1425269at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="33511" checksum="76C1E5E4C51FD36C" modified="2011-06-28" version="1">MALGLPSILPNPQPAIGELVRDRQPTFSFEFMPPKTEQGERQLWQAIRELEPLQPSFVSITYGAGGTTRDTTVAVTERVATETTLLPMAHLTAVNHSVAELRHVIGRLAGAGVRNVLAVRGDPPGDPTGEWVRHPDGIDYAEDLVRLVRRSGDFSVGVAAFPYRHPRSPDIASDTEYFVRKCRAGAEFAITQMFFDADEYLRLRDRVAAAGCDTPILAGVMPVIRIGTIERSVQLSGAPFPPALAARFERVADDPEAVRRLGIEQASEMCQRLLDEGVPGIHFITFNRSTATREIWQNLRVGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Z0</accession>
    <name>F4F1Z0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched chain amino acid ABC transporter periplasmic ligand-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736369.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03265"/>
    <dbReference type="EnsemblBacteria" id="AEB47737">
        <property type="protein sequence ID" value="AEB47737"/>
        <property type="gene ID" value="VAB18032_03265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03265"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_7_0_11"/>
    <dbReference type="OMA" id="LASTCML"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307332" evidence="1">
        <location>
            <begin position="27"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="55"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="408" mass="43153" checksum="C2B84765C33460E5" modified="2011-06-28" version="1">MRLKGRLVVATLASTCMLFAAGCGNATGDSNSSAGSSANGCDTKEIGPGVTDSEILVGTTMPLSGSGAAGGLGTKEGQEAYYAKLNAEGGVQGRKIKPIILDDAYDPSTAQKQMRQLVEKEEILVVSGGEGTPNFLGAVPYLDRKKVPAIAPYAPSDELGGDKNQHVFMATVDYIQEFEILTDYVLDQETPKKMALVGVAGNVGDNAKLGMEKALEGKGIELLYVPETPGTTDFTPIATQLKQFDAEYVFLILTNADTGGLLQAMSRIGYTPKTGAWAGMSDDSYIKEFGALSQDMLVALETSSLDSENPLVKQFVADFTAQTGKAPSKFNQLGWVQAQLTAEALKRAEGLNRGCVVEALETFENFETGILPPVTWGKGDRAGVDAVGIGQIKGDKLVVLEETKSLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F207</accession>
    <name>F4F207_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736386.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03350"/>
    <dbReference type="EnsemblBacteria" id="AEB47754">
        <property type="protein sequence ID" value="AEB47754"/>
        <property type="gene ID" value="VAB18032_03350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03350"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_2_3_11"/>
    <dbReference type="OMA" id="LHNARYP"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="16400" checksum="4B88069D8997C3AA" modified="2011-06-28" version="1">MSNAVADPTAVEYGHVEHAMVHFDDLDAMGILHNARYALLLERALTAYWSANGVALQNGQATTPDVFHAVREFAITYRAPITGTGPVGVHFWLEHLGTSSAVYAFRFHSLDGTTVYAEGRRAVVRLDPATLRPAPWTDTARGIASALLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F227</accession>
    <name>F4F227_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VanW family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_03450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736406.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03450"/>
    <dbReference type="EnsemblBacteria" id="AEB47774">
        <property type="protein sequence ID" value="AEB47774"/>
        <property type="gene ID" value="VAB18032_03450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03450"/>
    <dbReference type="eggNOG" id="COG2720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011572_0_1_11"/>
    <dbReference type="OMA" id="FYIERYP"/>
    <dbReference type="OrthoDB" id="967747at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="3">
        <location>
            <begin position="241"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="605" mass="65112" checksum="21E40EC8D31B0C4F" modified="2011-06-28" version="1">MTLYGENRPPADDDRPTVQVKAVSWPVEEPERPTPVDPPQGSAKRSRRVRILLATGVATAVLASVGVVAAWTYAGDVPRGTTVLGTELGGRSRADAARELQAQLDRRAAELAAPIEVRVGERTAQINPAEVGLTVDVDATVAAAAAAQAHAVDRLVGSREIEPVVSVDVPKLEAELQKLVGKQGRKMTMPAITFSGTTPKARHPKPSLALDTEHSAQVVKEGWLSGQPVTVPLVENHPVTSADEVDRLVEELAKPAVAAPVKLNTDRGTVTIPPQAIAKSLQFKADKAGKLTPSVDAKKLRSALGDRLDKVEVAPKNATMTISGGKPKVVDGRAGKQVDIGKLRDDLLAVLPRTDDRTISADLKPVTPKVTAEKISGLGIKEKVSSFTTYFTGGLSSPRSQNIVTIAKHVDGTVVLPGDTFSLNGHTGERGYAQGYRDAPVILDGKLVPGVGGGTSQFTTTLFNATYYAGLEDVEHKPHSYYFSRYPAVIESTIFWPNLDFKFRNNTEYGVLIDTSYTANSITVSIWSTKIWDSVKTEYGPRRNITSPKTVYLEPGPSCIPANGSQGFTQDAFRVIKKDGKVVKREKFTWTYDAEPRFICAKEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F240</accession>
    <name>F4F240_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731402.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08055"/>
    <dbReference type="EnsemblBacteria" id="AEB42729">
        <property type="protein sequence ID" value="AEB42729"/>
        <property type="gene ID" value="VAB18032_08055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08055"/>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099415_0_0_11"/>
    <dbReference type="OMA" id="HESHEQR"/>
    <dbReference type="OrthoDB" id="2060110at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307339" evidence="2">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="201" mass="21059" checksum="0F512BF5C637AE5E" modified="2011-06-28" version="1">MGQLLLLVVVAVTVAAVVFGVTVLVNGQDPGLVPAEADGRAVPLPGDRPLRESDVGEVRFDTALRGYRMAQVDQAMRRAAYDIGYKTELIGVLEAEVTALREGRTAEADALRSAREQSASLARGPAPEATRDSDGAVDIDLDKHDAEPDDTTTKPTDPATKADPATKADAAAKTDLATRAEEGDGVAEEEPRASAVRAESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F269</accession>
    <name>F4F269_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08200"/>
    <dbReference type="EnsemblBacteria" id="AEB42758">
        <property type="protein sequence ID" value="AEB42758"/>
        <property type="gene ID" value="VAB18032_08200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08200"/>
    <dbReference type="eggNOG" id="ENOG5033M2G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186189_3_2_11"/>
    <dbReference type="OMA" id="KILMWAG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="52" mass="5590" checksum="50784D59EB0A1AB8" modified="2011-06-28" version="1">MVKKVLTWAGIAFLIFFVAYRPNSAADVFKSLGGGIMDIAQGFGDFFTSLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2B4</accession>
    <name>F4F2B4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42803">
        <property type="protein sequence ID" value="AEB42803"/>
        <property type="gene ID" value="VAB18032_08425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08425"/>
    <dbReference type="eggNOG" id="ENOG5031T2Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151362_3_0_11"/>
    <dbReference type="OMA" id="ARPSWDC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="90" mass="9963" checksum="3705CC9F7F56A006" modified="2011-06-28" version="1">MTQADTGAVAVVPDEHAPLTPDWTCGTCGAQWPCEQKRDRLLSEYLTDRAMLSVYLGACLAAAAEDLHLSGSTSLQDRFLGWLPRRPRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2D4</accession>
    <name>F4F2D4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_14470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14470"/>
    <dbReference type="EnsemblBacteria" id="AEB44006">
        <property type="protein sequence ID" value="AEB44006"/>
        <property type="gene ID" value="VAB18032_14470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14470"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_33_11"/>
    <dbReference type="OMA" id="CLAVTTM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313518" description="Histidine kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="224"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="472" mass="49615" checksum="31A1236516A7F443" modified="2011-06-28" version="1">MGVLLALVFLVPLGLTLGSQAREEAIADAARRSALVTGALAVSTDPDVVARAIEASGDDAATRPVVHGLADAAADSDSDVAATGRADADQLAQAQAERRSVVLDVDGGVLRLDPVVLADRTAVVEVFVPDSALGGDAGNRWLLLAGVAVALVGAAVLVVDRVAARTVDATRDLVKAALAVGDGDLGVRVEPSGPRELAEAGHAFNRMAERLVAARTDERELVADLSHRLRTPLTVLRLDAEALEPDDTSVGSFSQAELDHRRGIRRIRQAIVTLEGEIDTLIKTTRKAVATEAGPAMCDVSEVVRDRMVFWAALAGDQNRPHRVIGAQLRIPAPVPRAELAAALDAVIGNVFRYTPQGTAFEVAVSRRDGYVAIRIDDAGPGIPDADRALRRGASDQGSTGLGLDIAKRVALQANGSVSIDRARLGGASVVMLLADPEATPRQVSRFGLVGRMAREQKSSGRRWPRQRPTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2L1</accession>
    <name>F4F2L1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733930.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20880"/>
    <dbReference type="EnsemblBacteria" id="AEB45276">
        <property type="protein sequence ID" value="AEB45276"/>
        <property type="gene ID" value="VAB18032_20880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20880"/>
    <dbReference type="eggNOG" id="ENOG5030ACM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2844942_0_0_11"/>
    <dbReference type="OMA" id="MDPSAVW"/>
    <dbReference type="OrthoDB" id="1953036at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="7622" checksum="B49D26C4C885CB72" modified="2011-06-28" version="1">MDPSAVWRDRQHRWRIEAYRAPDLRFAIFATNGTTESAPLWLFGMSALARWLMSHKISLDDLETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Y0</accession>
    <name>F4F2Y0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27591"/>
    <dbReference type="EnsemblBacteria" id="AEB46591">
        <property type="protein sequence ID" value="AEB46591"/>
        <property type="gene ID" value="VAB18032_27591"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27591"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143569_0_0_11"/>
    <dbReference type="OMA" id="ILELWVP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="154" mass="17313" checksum="BF10D7C6432E333A" modified="2011-06-28" version="1">MIGEPWLARCRAVNAVVSVVDKPILSGLTIDGSSGVRMSDDVNTTVLWRPTGPRERELVRASGWRAWPPRLPDQPIFYPVLNEDYAIKIARDWNVPASGAGYVTRFHVETDFLSRYPVRQVGGDTILELWVPAEELDEFNSHIVGQIEVVHEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F321</accession>
    <name>F4F321_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736432.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47800">
        <property type="protein sequence ID" value="AEB47800"/>
        <property type="gene ID" value="VAB18032_03590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03590"/>
    <dbReference type="eggNOG" id="ENOG50321CU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121973_0_0_11"/>
    <dbReference type="OMA" id="CYAYQVD"/>
    <dbReference type="OrthoDB" id="1795813at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307367" evidence="2">
        <location>
            <begin position="28"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="20004" checksum="D6C668DEE571EC18" modified="2011-06-28" version="1">MTPLVRVLTLVVLGSALVACDRAPVDAPSPSPTAPSPSASPGDLAVPPLQLPSVAPDGTCPVAEPQRWSNPGQAQRVLGPGPVYPIADYFTGGALPLRPSDRQVDGSYTAKVRWLAADYTGPVLVRAGRIDAPGAASAQFSYLGEPRHDGHHAVLTRPETDLPGTTTVDGPGCYAYQVDGTSFSYTIVFRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F381</accession>
    <name>F4F381_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736492.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03890"/>
    <dbReference type="EnsemblBacteria" id="AEB47860">
        <property type="protein sequence ID" value="AEB47860"/>
        <property type="gene ID" value="VAB18032_03890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03890"/>
    <dbReference type="eggNOG" id="ENOG5033K8W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135004_1_0_11"/>
    <dbReference type="OMA" id="PWARIER"/>
    <dbReference type="OrthoDB" id="2003922at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="16404" checksum="42CE20EAAC5A5F76" modified="2011-06-28" version="1">MQWRIPAALPVLKLVGAAGLLALGFLLAEGDLLRPVAGALGAALLAGWGVRDVIAPVRLAVDPSGITVPKGWTGRQHLPWSAVESIRVQRRPGRGFAGPALEIDTSETLHLFSRLDLGTDPEEVADALAAVRPEPARPSRPPSGEQSDGTDQSRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F386</accession>
    <name>F4F386_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, tatd family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731481.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08460"/>
    <dbReference type="EnsemblBacteria" id="AEB42810">
        <property type="protein sequence ID" value="AEB42810"/>
        <property type="gene ID" value="VAB18032_08460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08460"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_3_11"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="31978" checksum="716888FAF6CF5F33" modified="2011-06-28" version="1">MLSLMSQPTESRSQRAARRAGEFPPAPEPLPRPVLDSHTHLDITVSEVGVPGAGDATDPVTAAIDVATAVGVDRLVQVGVDVESSRWGADVADRHPAVLATVALHPNEAPRLADLDAALREIESLAARDRVRGVGETGMDFFRTGDDGRAAQEESFRAHIAIAKRYGKTLVIHDRDAHADVLRILDDEGAPDTVVMHCFSGDAQFAAECVRRGYLLSFAGTVTFASAGSLREAAALTPLDQILVETDAPYLTPMPYRGRPNASYLIPLTVRALADATGADLDDLCAAISTTGERAFGPWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3B1</accession>
    <name>F4F3B1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731506.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08585"/>
    <dbReference type="EnsemblBacteria" id="AEB42835">
        <property type="protein sequence ID" value="AEB42835"/>
        <property type="gene ID" value="VAB18032_08585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08585"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_11"/>
    <dbReference type="OMA" id="LWVDTEQ"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307387" evidence="1">
        <location>
            <begin position="30"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="433" mass="45742" checksum="AFEB48E1DB8EA082" modified="2011-06-28" version="1">MRRTARGIAVLASASLALTVAACGGEDKAAEEQPKADPASLTAELTWWDTSDPQNEGPAFKELIAKFNQTYPNVKINYQSVPFGEAQNKFKTAAQAKSGAPDILRAEVAWVPEFASLGYLYALDGSELLSDASDFLATPLASNKYDGKTYGVPQVTDSLALMYNKELLTKAGISAPPKTWAELKSASQTIKDSTGAEGVYVNPAGYFMLPFMYGEGGDLVDPEAKKIIVNSEQNAAGLAIAKDLIDSGAAAKPSANDAYGTMMTLFKEQKVAMIINGPWEVNNVSSAPDFGGLENLGIAPVPAGSARAGGPVGGHNYVIWSGMPQEKIDAAVAFVKFMASAESQAFLSEKLGLLPTRTSAYQVDAVKNNPVVAAFQAVNEAAVGRPWIPEAGQFFGPLDQMATEVLIQNKDPKAALDGVAKKYKAEVVPGYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3C4</accession>
    <name>F4F3C4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08650"/>
    <dbReference type="EnsemblBacteria" id="AEB42848">
        <property type="protein sequence ID" value="AEB42848"/>
        <property type="gene ID" value="VAB18032_08650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08650"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2144806_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12462" checksum="46584F9E368C6C86" modified="2011-06-28" version="1">MATRRFDLADAPLFVAEGIFAAEIVEECRRRDLLAGAYALRRPRSATFLRRLSRDLAEQRKGPRVLLSRGVALLRAEPAVLRRQTGLGAEAARGREVLRRVAHLLAGHPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3P6</accession>
    <name>F4F3P6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase, sigma-24 subunit, ecf subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_21235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734001.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21235"/>
    <dbReference type="EnsemblBacteria" id="AEB45347">
        <property type="protein sequence ID" value="AEB45347"/>
        <property type="gene ID" value="VAB18032_21235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21235"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_1_11"/>
    <dbReference type="OMA" id="DPEHHAM"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="31740" checksum="C5A0C56DEC5D0F86" modified="2011-06-28" version="1">MDGRTWLAERFEEHRPHLRAVAYRMLGSLGEADDAVQETWLRLSRTDVDGVDNLAAWLTTVVARVSLNTLRGRRRRREEPLDVRVPDPVVAPAGPDDPEYAAVLADSVGLALLVVLDTLTPAERLAFVLHDMFAVPFDEIAPMIDRSPTAARQLASRARRRVRGQAPRPDADLARQRQVVDAFLAAARDGDLDALVGVLHPDVVLRADGGVARTRHTTVLTGARDVAAQAVTFGRFSPFARPAVINGSAGVVVTAAGRPLSVMAFTVSAGLIAEVDVIADPDRLARLDLAAFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3P7</accession>
    <name>F4F3P7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734002.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21240"/>
    <dbReference type="EnsemblBacteria" id="AEB45348">
        <property type="protein sequence ID" value="AEB45348"/>
        <property type="gene ID" value="VAB18032_21240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21240"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_5_1_11"/>
    <dbReference type="OMA" id="INNIAWL"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="27022" checksum="BD4E9705C67523BF" modified="2011-06-28" version="1">MHPPILVTGGTGTLGRLVVPLLHEAGHRVRVLSRHGGQPSPGVTHVTGDLATGEGVDSAVRDVQIVLHLAGGQKGDDQLARTLARAAQQAGVRHLVFVSVIGADRVPLAWLRMKLAAEQAVADSGVPWTTLRAAQFHELTLTLVRKMSALPVIPAPGGMRLEPVDGREVAARLAALAQAAPAGLVPDLAGPQVYALGELIRSYLRATGRRRLLMPVRMPGSAGHAYREGANLSLPGATRGTRSWGQFLADQVGHSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Q1</accession>
    <name>F4F3Q1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21260"/>
    <dbReference type="EnsemblBacteria" id="AEB45352">
        <property type="protein sequence ID" value="AEB45352"/>
        <property type="gene ID" value="VAB18032_21260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21260"/>
    <dbReference type="eggNOG" id="COG4842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051020_1_0_11"/>
    <dbReference type="OMA" id="MAEAWLR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="438" mass="47022" checksum="CCC61B2438B13124" modified="2011-06-28" version="1">MTGNPLVAAPVHTGPSAWAGVWILEDIELIHQGVTTGSWIDGTLGVVSAGLDALAFVSDPVGALLQYGIAWLIEHVKPLSEALDWLAGDPAQITAHAQTWRNVASALRDEAATLARDVTTDIAAWQGEAARAYRAWSTEQHQALTGLAQGADTMAAITEGAAGLVAAVRLLVRDTIATCVSRLIVYATELIATAGLATPLVVEQVTTLVAAWAARIARLLRGLLNSLRHLIPTIRRLGTLIDQLKKALARLRDAPSGGRRSPEENPRGQRQPGSEPRPPDFDPGKHRGALGDEFRPGTQDPHGLFDDKERHVADRLGAEGIMVHPRERIDDIEFQKNPDAMTRASPDDPGVVTELKSLNQASSEAVRRNILTAGKQLEQEGGGDVVIDGRAVGLTEDEARRGYARAVGHHRQHGTPLPDRVQIILGEDRIITLPDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3S3</accession>
    <name>F4F3S3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RCK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734027.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21370"/>
    <dbReference type="EnsemblBacteria" id="AEB45374">
        <property type="protein sequence ID" value="AEB45374"/>
        <property type="gene ID" value="VAB18032_21370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21370"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029337_0_0_11"/>
    <dbReference type="OMA" id="HEPDWAL"/>
    <dbReference type="OrthoDB" id="1149824at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="600" mass="67247" checksum="57FEED1865ED905D" modified="2011-06-28" version="1">MTYPSSGFGRPSAWWLRVVFGIIGVVALVLGGIGFDRLRTERPDAIHDSYDVLYYTLQLFVLSAEPFENPGPYPWQLQVARFVAPLFTLLAVAEAARLLLAAEIRRLRARRASGHALVCGDSQFAHMLADRLYADGERVVVVRSEAFGPLEYRRRRYLGVIGDPTSVEVLRGAGLPRAHTIYACTHDDDLNHAIANAASRLIQDRRNPPRVYVQVHDPEMCLSLQARRLGAAGSSRLRLDYFHVDDIAARALHRHHPLRPTRDRTATVLIAGNGSFRRALLVETARHWRAQRTRSNLAAAPLRVDLVAPDARAEFALVAARYPFLRTVCQVSTYDRQVEELTGLAQFTAGGYDRIYICLPDEDSGLQFALDTPALWQGTRSTVFVPVYRQAALAAAFHGDSRHDLLDEVHGKLCLYPVLTHACEAELIAEDLTERLAQQIHERYLHARQQAGVRLGDAPAMVHWSRLPESLRRANRSHVQDIAAKLLNLGCVVAPRHGHTGDASAAGQAIAERVEQLARLEHERWCQERRTEGWTYGEPRDDLRQRHPELRPWDELSPAVQEQNREEIRALPDVLSDSGFELIRLTTPVPAPRPGAADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F465</accession>
    <name>F4F465_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03980"/>
    <dbReference type="EnsemblBacteria" id="AEB47878">
        <property type="protein sequence ID" value="AEB47878"/>
        <property type="gene ID" value="VAB18032_03980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03980"/>
    <dbReference type="eggNOG" id="ENOG5032YM2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136228_1_0_11"/>
    <dbReference type="OMA" id="GHTYVRS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="116" mass="12707" checksum="1722CCE895B988CB" modified="2011-06-28" version="1">MVLAEVSGRRQRAGGARTELTQQTRVGETLIRGLVRAQLALALQLSAVVLVGLGGLPWLFAIAPSVGRMTVLGVNLPWLLLAVLSFPFLVAVGWTYVRLAERNEQDFTDLVQRPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F491</accession>
    <name>F4F491_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Had-superfamily hydrolase, subfamily iib</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736536.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04110"/>
    <dbReference type="EnsemblBacteria" id="AEB47904">
        <property type="protein sequence ID" value="AEB47904"/>
        <property type="gene ID" value="VAB18032_04110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04110"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_0_11"/>
    <dbReference type="OMA" id="WFWAYST"/>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="29267" checksum="8B25660DF6B9A644" modified="2011-06-28" version="1">MTRPGLPKLIATDLDGTLVRSDDTVSAYTHEVLDRVRAAGIPVVGATGRGPRLTELTRNDIRAADFLVMAGGGRVVDQSDPAGPVVLRDERLSSEVLATLLADLEAAVGPLTVMVEASDEHDAPLWGDYHPAWPYQDRFEVRTRDECLAGDVIKAFARTADHHVDELLAVARQIIPPHLAALTQAGLGFIEISPSGVDKATGLSVVAQSLGVDPAEVLVFGDMPNDLPMFEWAGWARVAVANAHAELRAVADDVTLRNDDDGVAVYLDRLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4F6</accession>
    <name>F4F4F6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_08980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731585.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08980"/>
    <dbReference type="EnsemblBacteria" id="AEB42914">
        <property type="protein sequence ID" value="AEB42914"/>
        <property type="gene ID" value="VAB18032_08980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08980"/>
    <dbReference type="eggNOG" id="COG1877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037265_0_1_11"/>
    <dbReference type="OMA" id="HKLAKHP"/>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="29407" checksum="DE62A6F0718BD542" modified="2011-06-28" version="1">MPPLNLGDQQPKIPLNADQAWRITADRAGETVLFFDFDGTLAPVADDPTKVQPAPKVLAAIEALAPVVRRIAIVSARPVEFLREHFDGLSGVDLYGLYGLEHSHSGGETVTEPAALPFVPTMSELADLARAELPAQALVEYKRLSVALHWRTAPQLADTVEQWGRAQAERLGLRVQIGRMVLEVKPPVDRDKGMVIDELVQDAGGAWYFGDDVSDIKAFAALRARAAADADFMGVCVAVANPETGAEVAEAADLTIDSPAALGDFLTEATHHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Y4</accession>
    <name>F4F4Y4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734126.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21865"/>
    <dbReference type="EnsemblBacteria" id="AEB45473">
        <property type="protein sequence ID" value="AEB45473"/>
        <property type="gene ID" value="VAB18032_21865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21865"/>
    <dbReference type="eggNOG" id="COG2312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039169_0_0_11"/>
    <dbReference type="OMA" id="ETNEHIT"/>
    <dbReference type="OrthoDB" id="1787757at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045676">
        <property type="entry name" value="DUF6194"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19694">
        <property type="entry name" value="DUF6194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="529" mass="57628" checksum="FC623B5FC1E9BBCC" modified="2011-06-28" version="1">MTSLLDLFAVPPSLLALGEPTHGESAFLQIRNEVFLSLAEHGYRSIALESDRAAGLIADDFVQGSAAVPLDRALAEGFSHGFGAAPANRDLLLRMREWNAGRPAAERLTFHGFDAPLELEGAPSPRRHLVRVCEFLDLDRSAEIDDLVGDEARWSDPAAIWEPGRSIGGSADAQRLRVIADDLLTELYLQAPRRPEGWQAAFVHAMSAVAVLRYHAAAAAPLTQEARFARLAGVRDALMAENLLAIRSVEAHRGPTVVFAHNTHLQRQLSTMTMAGTDLSWAGAGAIVSSLLGDRYAVIVGSLGASPALGIEAPALSTYEGRLQQDTGLPRYVRASDIEPAERRTHDYRYFPLDDATVAHADAVLHIPTGVGAATLAERILALPGVEQVVASQENGSPEVAWGDRFFHVGADRRQPFATIVEHDVPGFDEASQLDRPGVFRLNLDLGRAEFERRFGFPPKDFEEHRHEFDFARLDTVVPHPGYALHGFASIVMPGPHLLPEVDQLLAVAHARAVDRHERAVRRAAGQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Y5</accession>
    <name>F4F4Y5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S51 dipeptidase E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_21870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734127.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21870"/>
    <dbReference type="EnsemblBacteria" id="AEB45474">
        <property type="protein sequence ID" value="AEB45474"/>
        <property type="gene ID" value="VAB18032_21870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21870"/>
    <dbReference type="eggNOG" id="COG3340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244705_0_0_11"/>
    <dbReference type="OMA" id="DFSIFPH"/>
    <dbReference type="OrthoDB" id="1485646at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="221" mass="23638" checksum="22BFC9D32C66FE6B" modified="2011-06-28" version="1">MKLLLTSGGVTNPSIHTALRELLGKPVSESRALCIPTAQWGHPMCGPASVRGLVAADPGSDWRYLSGLGWGSLGVLELTALPSIGAQRWVPWVRETDVLLVDGGDATYLCHWMRESGLADLLPSLPDLVWVGVSAGSMVMTPRIGAYFVEWASAPDDRTLGVVDFSIFPHLNLFPTNTPADAQRWAADIGGPAYAIDEQTAIKVVDGAVDVVSEGQWTRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F505</accession>
    <name>F4F505_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, gntr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734147.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21970"/>
    <dbReference type="EnsemblBacteria" id="AEB45494">
        <property type="protein sequence ID" value="AEB45494"/>
        <property type="gene ID" value="VAB18032_21970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21970"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_1_11"/>
    <dbReference type="OMA" id="ERDGWIY"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="131" mass="14577" checksum="58BFCBCE28F761D8" modified="2011-06-28" version="1">MFVFRLDTRSGVPPYLQLVQQVRQAVLLGFLQPGDRLPLIREVVEDLAINPNTVAKAYRQMEQENLVTGRPGQGTFVNAQQSAAMSASTYTSLRRGLATWLRRAYAAGLDEQAVNALFTSVHQQTRNEDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F670</accession>
    <name>F4F670_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxopent-4-enoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735471.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28756"/>
    <dbReference type="EnsemblBacteria" id="AEB46822">
        <property type="protein sequence ID" value="AEB46822"/>
        <property type="gene ID" value="VAB18032_28756"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28756"/>
    <dbReference type="eggNOG" id="COG3971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060136_4_0_11"/>
    <dbReference type="OMA" id="RIVGHKI"/>
    <dbReference type="OrthoDB" id="1314120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="27929" checksum="654DB2D37E27345C" modified="2011-06-28" version="1">MSDLQRAAEELTEARTSGKPCPPLRGRLLPEGDVAAAYEVQQHQVRQWLAAGQRRVGAKIGLTSRAVQENLGVYEPDFGVLTDVMAVPDGAEVPIDRLLQPRVEAEIAFVLGADLPDERVTSVDVIRAVDHLLPAIEIVDSRVAGWDISIVDTVADNASSGLFVLGTAPRRLADVDLRLCGMVLEHAGEPVSVGAGAACLGNPLHAVAWLATTMARAGEPLRAGDVVLSGALGPMVAVTPGAAYEARISGLGSVRTCFSREAKGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F673</accession>
    <name>F4F673_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">kynU</name>
        <name evidence="7" type="ordered locus">VAB18032_28771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>H2O + L-kynurenine = anthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28771"/>
    <dbReference type="EnsemblBacteria" id="AEB46825">
        <property type="protein sequence ID" value="AEB46825"/>
        <property type="gene ID" value="VAB18032_28771"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28771"/>
    <dbReference type="eggNOG" id="COG3844">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_4_0_11"/>
    <dbReference type="OMA" id="WLPYHEL"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061981">
        <property type="term" value="F:3-hydroxykynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="88"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="425" mass="46292" checksum="EA5470441ABE4F67" modified="2011-06-28" version="1">MSAGEAEALRLDAAEPGHRHLFHVPPADGGRYPETAYLAGNSLGLQPKATRTELLADLEAWSRLGVEGHLEAERPWLPYHELLTAPAARLVGALPSETVVMNSLTVNLHLLMVSFYRPAGERTRIVIEDSAFPSDSYAVRSQARFHGLDPDTTVVRLTPRPGEENLRTEDVTAFLAAEGHTVALVLLGGVNYLTGELMDIPTITAAGRAAGAVVGWDLAHAAGNVPLSLHDWDVDFAAWCSYKYLNSGPGALGGVFVHERHHGDPALHRFEGWWSTAAATRFEMTPVSRPPATVEAWQISNPPIFAMGPVRTSLELFDSVGMPALRERSLRLTGYLERLLDEVVADRPLTVVTPRDPSRRGCQLSVRIGVGTANELTKRLRHEHGVIADARQPDVVRFAPVPLYSTYHDCWRVADALAATVEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F679</accession>
    <name>F4F679_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MscS mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_28801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28801"/>
    <dbReference type="EnsemblBacteria" id="AEB46831">
        <property type="protein sequence ID" value="AEB46831"/>
        <property type="gene ID" value="VAB18032_28801"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28801"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_8_1_11"/>
    <dbReference type="OMA" id="GMQDTLT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="37352" checksum="45E6DF06CA64786B" modified="2011-06-28" version="1">MTVSMLSLVPGTPTPGPEDTPSPECLDEVVCKWVWKYSDSVWFAEGSYWILVKPLRIILILMLAIAARWLVHRTIRRLVRTTTDAGVPTMLRPLRERIPSAATEPGEFVPERRRQRAEAIGSVLRSLSTAFIFGIAVLMVLKEFSFDLAPLLASAGIAGVALGFGAQSLVKDLIAGLFMLIEDQYGVGDNVDLGEASGVVEAVGLRVTTVRDGRGVLWYIRNGEIVRVGNKSQGWALVVVDLPIGFAGTEEATAVLRTAAASVAVDPELAASIVEPPEVLGVEQVTVDGTVIRTVVKTTADGQAAVGRELRRRLAEALENSGITARIAAVRAVPAYLRDDNETGQGGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6S2</accession>
    <name>F4F6S2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734249.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22485"/>
    <dbReference type="EnsemblBacteria" id="AEB45597">
        <property type="protein sequence ID" value="AEB45597"/>
        <property type="gene ID" value="VAB18032_22485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22485"/>
    <dbReference type="eggNOG" id="COG4674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="VLCEGTM"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017781">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03411">
        <property type="entry name" value="urea_trans_UrtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="27709" checksum="F30EF7E3E68DCA38" modified="2011-06-28" version="1">MTEQLPGLYVRDLRVSFDGFTAVDGVSLDVAPGDIRFLIGPNGAGKTTLVDAVTGLVKATGSVRFDDRELLGRPVHRISRLGVGRTFQTSTVFEELTVLQNLDIAAGARRGWATLLRRRHGIPDEVAEALEVIGLAGRADQLAGTLAHGQKQWLEIGMLLVQDARLLLLDEPVAGMSHEERDATGELLEQVSRDRTVVVIEHDMDFLRRFARTVTVLHAGRVLSEGSVAQVQADPRVQEVYLGHPVDAGPTPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6V9</accession>
    <name>F4F6V9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">smpB</name>
        <name evidence="4" type="ordered locus">VAB18032_22670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734286.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22670"/>
    <dbReference type="EnsemblBacteria" id="AEB45634">
        <property type="protein sequence ID" value="AEB45634"/>
        <property type="gene ID" value="VAB18032_22670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22670"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_0_11"/>
    <dbReference type="OMA" id="FGSWTNH"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="18457" checksum="4D166ABC0959B9C1" modified="2011-06-28" version="1">MSTSRSGERTFVASNRKARHDYTILKTYEAGIVLAGTEVKSLRAGRVSLVDAFAQERDGEIMLYGLHIAEYGYGSWTNHAPRRTRKLLLRRVEIDRILAQIREGGFTLVPLSMYFSDGWAKVELAVAKGRKSYDKRQALAARDADREIARELGRRLKGRSRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Y5</accession>
    <name>F4F6Y5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_22800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22800"/>
    <dbReference type="EnsemblBacteria" id="AEB45660">
        <property type="protein sequence ID" value="AEB45660"/>
        <property type="gene ID" value="VAB18032_22800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22800"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_0_11"/>
    <dbReference type="OMA" id="AGETTWH"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="30912" checksum="EBB3BF4AAB469D64" modified="2011-06-28" version="1">MTGAGGMLGRDAVEVLAGHPDHTVTAVTRTQLDVTDAAAVADAVAGHDVVLNAAAWTDVDGAEQDEAAATAVNGAAVAHLATACATHGAYLLHVSTDYVFAGDADTPYPEDAPTAPVNAYGRSKLVGEQAVRRLLPDRGHVVRTAWLYGTHGRNFVTTMLGLAQQRDFLDVVDDQRGQPTWSYALAEQLVRLAEAARDGRARPGIWHGTCTGETTWYGLARAVFALHGLDPDRIRPTTSSRFPRPAARPAYSVLRHGRWTEAGLSPLPDWHTTLTEAFTPAAPPSPWKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F721</accession>
    <name>F4F721_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATPase/permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_29071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735534.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29071"/>
    <dbReference type="EnsemblBacteria" id="AEB46885">
        <property type="protein sequence ID" value="AEB46885"/>
        <property type="gene ID" value="VAB18032_29071"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29071"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="HERADYA"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="341"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="594" mass="63694" checksum="1B3D367971A28365" modified="2011-06-28" version="1">MIEAIRGSGRLLATAWRLDRRRAALSVVLVLAGAAAAPLMAYVLGQMTGQVVTGQAAAATRSGLLVAALAIAMLTFSHFAHIAYFELAEMAEEDFDEQLMTVSNGSPGIEHHDRPELADEITVLRREGRQLEGAMDALMNGLGLVLAMAVTGVLLAGVNPLLLLLPLAALPPLVAGRVAERIRDRARTATAEPTRVALNLFHQSTSAKVAGELRVFQLGDELTARHEQQWERATRGLTRGHFLATGVHAVGQVVFALAYVAAVLLVVRDAMTGRGGVGDVVLVIVLAVQVNQQVTTAVTLLQTLQRISAAFIRLRRLSADVAAADLGAAEQDLPERLRTGISLRDVSFAYHGTGREVLRDVNLDIPAGTRVAVVGENGAGKSTLVKLLCGFYQPTSGQVLVDGVDLTAVSPQRWRERISAGFQDFARYEFTLRQSVGLGDLPHADSVPHVRDALDRAQATPVVDTLPDGLDTQLGRSWTDGQELSGGQWQRLALGRAMMRGEPLLLVLDEPASALDPAAEHALFERFTEQAGRVSRASGAITLFVSHRFSTVRMADLIIVLRDGTVAEVGDHASLVAANGLYAELFELQARAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4F774</accession>
    <name>F4F774_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10070"/>
    <dbReference type="EnsemblBacteria" id="AEB43132">
        <property type="protein sequence ID" value="AEB43132"/>
        <property type="gene ID" value="VAB18032_10070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10070"/>
    <dbReference type="HOGENOM" id="CLU_3159096_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="48" mass="4985" checksum="F3F8A621F684BFDD" modified="2011-06-28" version="1">MLVTGMAIGTGVASFSVSPAAHLRLAKSGWTLLVLPVSRRSSVEESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F783</accession>
    <name>F4F783_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superfamily I DNA and RNA helicase and helicase subunits-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731812.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10115"/>
    <dbReference type="EnsemblBacteria" id="AEB43141">
        <property type="protein sequence ID" value="AEB43141"/>
        <property type="gene ID" value="VAB18032_10115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10115"/>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639266_0_0_11"/>
    <dbReference type="OMA" id="KFPDGWE"/>
    <dbReference type="OrthoDB" id="739613at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="445" mass="47288" checksum="4091637E8266AE4B" modified="2011-06-28" version="1">MRAEWDVPPGVEAERVITAVLADLRSGEHRGVVVDSPPGAGKSTLVVRAAVELAGAGEPLMVIAQTNEQVDDLIDRLARKAPELRVGRLSAGDYRPSARVRAHEQVRVAAKVTDLAASAVIIGTAAKWATVTEGRWPWAIVDEAYQMRSDALLRVAGRFERALFVGDPGQLDPFSTVEVGRWAGLTWDPMQSAVAVLLRHNPQLPVHRLPVSWRLPASAAPVVSTAFYPFSGFRAGTGSADRALRLTGAGRGDAVDRAVELATDTGWALYELPARHTLRTDAEAAAACAALALRVLARGAVAVCEQAPDGAPVTADRIAVGAAHRDQVAAIRAQLGETGAGITVDTANRLQGREYDMTIVLHPLSGRRDATAFHLESGRLCVLASRHRQACVVVARAGIGELLDAHPSTDVPQLDVPVKFPDGWEANQAILAHLRATAVPHQKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7F9</accession>
    <name>F4F7F9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-ACP synthase III</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">abyA1</name>
        <name evidence="3" type="ordered locus">VAB18032_16460</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2015-06" db="PDB data bank">
            <title>The structure of AbyA1, a tetronic acid condensing enzyme from the Abyssomicin polyketide synthase.</title>
            <authorList>
                <person name="Byrne M.J."/>
                <person name="Race P.R."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733058.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="PDB" id="5BY7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B/C/D=1-341"/>
    </dbReference>
    <dbReference type="PDBsum" id="5BY7"/>
    <dbReference type="SMR" id="F4F7F9"/>
    <dbReference type="STRING" id="263358.VAB18032_16460"/>
    <dbReference type="EnsemblBacteria" id="AEB44398">
        <property type="protein sequence ID" value="AEB44398"/>
        <property type="gene ID" value="VAB18032_16460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16460"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_11"/>
    <dbReference type="OMA" id="NQACHAM"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="254"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEK75497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="5BY7"/>
        </source>
    </evidence>
    <sequence length="341" mass="36082" checksum="AEB9CAA2344575D7" modified="2011-06-28" version="1">MTRTVSVLSAASALPGPTVDNATLGRRLGMDRLWEQWVDAFIGTRTRHLAVDLDSGEIRHTLADLAHQAGSRALDAAGVTPEEVDLVVLGTATPDRLMPTTATVVADRLGIDGVPAYQLQSGCSGAVQALAVTRSLLLGGTARTALVLGGDVVARFYDLTADLRKLPPAEFVNYVLFGDGVGAAVLRVGEVAGAAALRSVFTRLVGLGREPGATLEWFGPTEDRNRPAATEDYKAIERHVPDLAAEVVEELLGELGWARDDLDYVLPPQLSGRMTALIVERLKLPQATEVSCVAETGNNGNGIVFLQLERALARLAGGQRALGVSIESSKWIKSGFALEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7H8</accession>
    <name>F4F7H8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733077.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16565"/>
    <dbReference type="EnsemblBacteria" id="AEB44417">
        <property type="protein sequence ID" value="AEB44417"/>
        <property type="gene ID" value="VAB18032_16565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16565"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_3_2_11"/>
    <dbReference type="OMA" id="PEERFRC"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="29226" checksum="AF2FFC8137E04E43" modified="2011-06-28" version="1">MKSSITSVHLLDGGVLDVESSVVVPGSGFGRRIAVPVQMFLVGTTSGYVLVDTGNDPGVIDDPVGTWGADLAAASRPRMQPHQHPARQLALLGLAPRDVRAVVYTHLHHDHAGGGRVFPHAVHVVQRAEHRWATSPDGHAGTAYVPADFTATTWTLADGDWHMLPGLQLMMTPGHTPGHQSVVLWDVPDLGNVILAGDAINTVGCIDDGLPPGIATDTLAAVHSMHRLTALADATDALVVTGHDMTQFEALPKAPDPLRRPTGGPVHQARKMLDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7I8</accession>
    <name>F4F7I8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_16615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733087.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16615"/>
    <dbReference type="EnsemblBacteria" id="AEB44427">
        <property type="protein sequence ID" value="AEB44427"/>
        <property type="gene ID" value="VAB18032_16615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16615"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="EMPMMLS"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="309" mass="33556" checksum="57F15F21E4C38831" modified="2011-06-28" version="1">MSRRPLSLPQPPARASEFGRDALIVCENLVRIYQTGSIEVQALQGLDLTVDSGELVAVVGASGSGKSTLLSILAGIDAPTAGRVRVDRWSLLGMSRADRVDYRRHTVGFVRQQTASNLIPYLTAREMVDLPMTAARTGKEERRKRVAELLDSLGVADCADRRPGQLSGGQQMRVAIAVALANRPKVLLADEPTGELDAATSAEVFGVLRDVNRRYGVTVVVVTHNPEVSGQVERTVAIRDGRTSSEVLRRTTTDAVGDTHMVAEEYAVMDRAGRVQVPRDFRQALALTRRVRLALEADHITIRPSGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7K0</accession>
    <name>F4F7K0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_16675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16675"/>
    <dbReference type="EnsemblBacteria" id="AEB44439">
        <property type="protein sequence ID" value="AEB44439"/>
        <property type="gene ID" value="VAB18032_16675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16675"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051827_1_0_11"/>
    <dbReference type="OMA" id="DHRVGAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312754" evidence="3">
        <location>
            <begin position="22"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="376" mass="38457" checksum="1E7248510AF1734F" modified="2011-06-28" version="1">MRLLATIATGVVLLGASPAPPAPTPGASSAPSAVTWGVAPSSAKGPNGRPTFAYKLDPGATLTDYVAVTNHSPRPLTLNLYASDAFTTAQGGFDLLAGGQQPTDVGAWVRLTQGRVTIPSMSRLNVPFTLTVPDNATPGDHAGGIVASLAATTADAQGNQVAVDHRVGARIYLRVTGELQPALTVEELRVQHSGSLNPLGGGTLTATFTVRNTGNVRLTGRPTLGVAGPFGLGRRSIDAADLPEILPGGGLTTTVRMTGVPPLFRLTASGAVTPAAVGDQVLDPPPAVATARTSIWAVPWPQLVLLALLALVGFAVIAARRRRARQIARVVAAAREQGRIEASRDADRVSGDRDTAVPDAIGTGGPDVDHPGKDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7U2</accession>
    <name>F4F7U2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23145"/>
    <dbReference type="EnsemblBacteria" id="AEB45729">
        <property type="protein sequence ID" value="AEB45729"/>
        <property type="gene ID" value="VAB18032_23145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23145"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091968_0_0_11"/>
    <dbReference type="OMA" id="RPSWGYA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="55"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="27014" checksum="E78F7227E20E2C2A" modified="2011-06-28" version="1">MSGEASFDELVADGAAAPVEGWAFDRLAGRATEERPPWGYARLMAARMATVDAALDIDTGGGEVLAEVPHPPRLLVATEAWPPNVPVARARLRPIGATVVAVSPDAPLPLRSATFDLVVSRHPVRTDWPEVARVLRPGGTFLSQQIGPGTVRELSEAILGPLPPPAHRHPEQAVAAAEAAGLTVVDLRTATLRTVFHDVGAVVWFLRKVVWTVPGFTVAAHRPALARLHERIRTEGPFVAHAQRFLIEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F818</accession>
    <name>F4F818_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ordered locus">VAB18032_29611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29611"/>
    <dbReference type="EnsemblBacteria" id="AEB46993">
        <property type="protein sequence ID" value="AEB46993"/>
        <property type="gene ID" value="VAB18032_29611"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29611"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_0_1_11"/>
    <dbReference type="OMA" id="FTHAVRL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="28800" checksum="C47369273E5E407A" modified="2011-06-28" version="1">MSGQLVAAEGLPWPPSVGDFYPPDLAGPWVTKFTLMIWLAVGLLIIFFMATYRNPKLVPSKGQWMAESVYGLVRDNIAREQMGKDGIRFAPYFTVLFCFIVVTNLFGIVPGLQISPNSHIAFPIVLAVITYVMYLYIGVRKHGLGSYLKQTLIIPGVPWPMHFLLIPIEFLQNFINRPVTLAVRLFANMFAGHLILLVFTVGGFVMLASDNLFIQVSSIAAFLMAILMAFFEVLVALLQAYVFVTLTANYIGSSLADEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F836</accession>
    <name>F4F836_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3566 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730702.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04510"/>
    <dbReference type="EnsemblBacteria" id="AEB42028">
        <property type="protein sequence ID" value="AEB42028"/>
        <property type="gene ID" value="VAB18032_04510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04510"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046697_0_0_11"/>
    <dbReference type="OMA" id="ALFFIWM"/>
    <dbReference type="OrthoDB" id="1739074at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="181"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="301" mass="29750" checksum="CAB908B7D1B910C4" modified="2011-06-28" version="1">MTETQAKSGNTGPSANPVDEEAAQNGTPTTGRAAVGRATVPADAPAPKFTRAPGMAPPPDKPGEDQAAEAAEEKAGGEAAGSAAAAGKPSVTQPIATRAGQSASGTTGVLPTVGTGTTGTQPRVTGSAPKPDGARPLNTGRPANGGGLPPGVGTAAVGAARVGEAVRAARTSVSSAASRGPRRARLNLKRIDPWSVMKFAFAVSVVLFIVIVVATSVLYLALDAMGVFTSVNDSLSDLVNAGGGQGTSGFQITATGVIFTSMLIGAVNVVLFTALATLGAFVYNVCADLVGGIELTLAERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F882</accession>
    <name>F4F882_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase, MGT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10625"/>
    <dbReference type="EnsemblBacteria" id="AEB43243">
        <property type="protein sequence ID" value="AEB43243"/>
        <property type="gene ID" value="VAB18032_10625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10625"/>
    <dbReference type="eggNOG" id="COG1819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_7_2_11"/>
    <dbReference type="OMA" id="GMIWANL"/>
    <dbReference type="OrthoDB" id="1485440at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="388" mass="41131" checksum="3C14D7D870750F28" modified="2011-06-28" version="1">MRIAFLTTTQHGHLNPYIPVVNALQATGNEVVLLLLSADGGALGEQRRQALGPAEVHMVGQVQMAPWSDDPAKIGPMLESSPLADQVADALRATAPDFALLDSLPVLAAAMAGAQASGVPYGMIWANLGGVCPKERRRGRWLYDEQVGDYLTRHGVLWSTRTHSARSPILNLMPTIPSLVGDEAVTDDGVQLVGLPGAAGKRGDEVAFPGLEEIDPGRPLVFVSFGTIFFRRPDLLRTVIMGAVKTGAQVIAAVGDLAEELALPADVLTAPYVPQREVLARADVFITHGGYNSVAESIRAATPMLVIPLAVDQPIQAYFVETAGFGTAIEPADVTERAVADAVTDLLDPGRDCRARLRAAQPECGDSAARTAELVLSMGEKLPRKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8E0</accession>
    <name>F4F8E0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733142.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16905"/>
    <dbReference type="EnsemblBacteria" id="AEB44485">
        <property type="protein sequence ID" value="AEB44485"/>
        <property type="gene ID" value="VAB18032_16905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16905"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_3_3_11"/>
    <dbReference type="OMA" id="PGDWWEN"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="23254" checksum="382E60B846F1C92D" modified="2011-06-28" version="1">MATFVLIHGGGGSSWDWHLLGPELAGRGHDVVVPELPIEDRAAGFAEFCETVVNAVGDRSNLVVVGHSYGAFTAPLIADKLPVRLIVLLTPMIPKPGESPGDWWGNTGHRSADGFSEEEQFYNGVPAEIVAEASAHGRDQVSAEWNEPWPLGAWPDVPTRVLIAREDRFFPPDFQRRVAADRLNAVPDEIDGGHAVALSHPKQLADQLTAYLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Q4</accession>
    <name>F4F8Q4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734449.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45797">
        <property type="protein sequence ID" value="AEB45797"/>
        <property type="gene ID" value="VAB18032_23495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23495"/>
    <dbReference type="eggNOG" id="ENOG5033HME">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2439966_0_0_11"/>
    <dbReference type="OrthoDB" id="1930262at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="90" mass="9791" checksum="C5823C0DFF43EB2F" modified="2011-06-28" version="1">MASYADVLHYLSSLDYPAGKDDVLREAEREGAPPDVLRALRALPPVDYANGPEVARSAGIEAAPEVDDAQRAAAGRDKRHQRVSQHLRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F969</accession>
    <name>F4F969_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sortase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04855"/>
    <dbReference type="EnsemblBacteria" id="AEB42097">
        <property type="protein sequence ID" value="AEB42097"/>
        <property type="gene ID" value="VAB18032_04855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04855"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045680_5_0_11"/>
    <dbReference type="OMA" id="WTNVRAH"/>
    <dbReference type="OrthoDB" id="1022681at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="31713" checksum="4473756BE4BF7461" modified="2011-06-28" version="1">MDSTALMGAVPRPPQVEEPAGADQPTEPPKPRRGDRVVQLRAEQTGEGYKSVYSELTRPSFWSRVRTGLRFGGELLITFGLVVLLFAGYEIWGKSAIVDAHQDELSQQLAQAWGPEGDPTVAPSATPSASASPKPPVQGKPIAGLFIPKFDKEWIVVEGVTQKDIRYAPGHYPESAMPGQVGNFSVAGHRNRATFWRLDELRKGDPIIVQDRDQWYVYQVTENVIVKPHQVEVVAPVPGRPGAKPTKRMLTLTTCNPKFDNYERLIIHAELTRTQSKDQGRPAELGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F973</accession>
    <name>F4F973_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NLP/P60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C40.007"/>
    <dbReference type="EnsemblBacteria" id="AEB42101">
        <property type="protein sequence ID" value="AEB42101"/>
        <property type="gene ID" value="VAB18032_04875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04875"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034085_1_0_11"/>
    <dbReference type="OMA" id="AQWNEGK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="190"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="33340" checksum="6262CDF22ABDA996" modified="2011-06-28" version="1">MAAAAVGAGLLSAPAHAEPSVEEIERQIDKQWQQLEPTIEQYNKVRSQLKVNRKKSADLQKKIQPLALEAELAMNRVADLASRYYVNGPSQEIGAVLLNAKPDLLGEQMAMLERLAAYERQQLESVMKVRKKYDTQKAKLDALIADQEAKEKQLAAKKKQIDAKIKQLERSLPVTTVKTTNCPTINGVVSAAARTAIKVACAQVGKPYVWGATGPNSFDCSGLTQYAYKAAGIYLTHFTGAQWNEGKAISRSEARPGDLVFFRSDLSHVGLYLGNNLMVHAPRAGKPVNVSPITTMPIAGFRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9B3</accession>
    <name>F4F9B3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731978.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10945"/>
    <dbReference type="EnsemblBacteria" id="AEB43307">
        <property type="protein sequence ID" value="AEB43307"/>
        <property type="gene ID" value="VAB18032_10945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10945"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="LICDHVT"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="336" mass="35707" checksum="D5ED7571E7D1FAA5" modified="2011-06-28" version="1">MSGVIEIEGLRKTFRSVRKGHRVAVAGFDLLVEAGQVHGFLGPNGSGKTTTLRALLGLVRADAGQMRVFGADAPQSLPQVAHRVGAIVESPQFFGNFTGHRTLRLLALAGGVPVSRVDEVLEQVGLRDRGHDRVKGYSLGMKQRLAVASALLKGPELLILDEPANGLDPAGIREMRDLMRTLAGNGVTVLVSSHILAEIQLICDHVTIISRGRRVTAGPVTEVLAGFDRNECLVRADDLIRAEQLLQAAGLTVTAHADHLVVGGVPDPTLISRTLGEQDVWVRELTPVRPDLESVFLELTGAGQQPTLPRQTDGGSAPGPSGAPSIDLDEFRGVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9S1</accession>
    <name>F4F9S1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734499.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23745"/>
    <dbReference type="EnsemblBacteria" id="AEB45847">
        <property type="protein sequence ID" value="AEB45847"/>
        <property type="gene ID" value="VAB18032_23745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23745"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146613_1_0_11"/>
    <dbReference type="OMA" id="PEQWLIT"/>
    <dbReference type="OrthoDB" id="1562645at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="103" mass="11940" checksum="CA32A141CCE09511" modified="2011-06-28" version="1">MTRGRVVFLVRVPTERTDDFLRAYEAVRHLVADGVPGHLVDQVCRSATDPEQWLITSEWASLADFEAWERSPEHRDLVRPMRECFTDARSLRFHVHAQTPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAA1</accession>
    <name>F4FAA1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730836.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05180"/>
    <dbReference type="EnsemblBacteria" id="AEB42162">
        <property type="protein sequence ID" value="AEB42162"/>
        <property type="gene ID" value="VAB18032_05180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05180"/>
    <dbReference type="eggNOG" id="ENOG5032SFN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113711_1_0_11"/>
    <dbReference type="OMA" id="EHEPNRG"/>
    <dbReference type="OrthoDB" id="1793636at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014487">
        <property type="entry name" value="DUF3151"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11349">
        <property type="entry name" value="DUF3151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017349">
        <property type="entry name" value="UCP017349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="142" mass="15240" checksum="039B5FAA781B41AA" modified="2011-06-28" version="1">MQNLLPEPPATLLPADEEADAALTTAEQAGSDEAYAEAAARFPSHSAAWAVLATRAFAQDQAVAAYAYARTGYHRGLDQLRRNGWKGHGPVPWSHEPNRGFLRCLYVLSRAADEIGEADEAARCAQFLRDCDPAAADALASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAH1</accession>
    <name>F4FAH1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="5" type="ordered locus">VAB18032_11410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732069.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11410"/>
    <dbReference type="EnsemblBacteria" id="AEB43398">
        <property type="protein sequence ID" value="AEB43398"/>
        <property type="gene ID" value="VAB18032_11410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11410"/>
    <dbReference type="eggNOG" id="COG0611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_0_1_11"/>
    <dbReference type="OMA" id="HFRRDWS"/>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
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        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
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        <property type="entry name" value="ThiL"/>
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        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AIRS"/>
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    </dbReference>
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        <property type="entry name" value="AIRS_C"/>
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    </dbReference>
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        <property type="entry name" value="Thiam_monoph_kin"/>
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        <property type="entry name" value="SSF55326"/>
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    </dbReference>
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        <property type="entry name" value="SSF56042"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="163"/>
            <end position="259"/>
        </location>
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        <location>
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    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
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        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
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    </feature>
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        <ligand>
            <name>substrate</name>
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            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="133"/>
            <end position="134"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
        </ligand>
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        <location>
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        <ligand>
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        </ligand>
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        <location>
            <position position="221"/>
        </location>
        <ligand>
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            <label>3</label>
        </ligand>
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        </location>
        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
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        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="32724" checksum="D104D38DA40353EA" modified="2011-06-28" version="1">MSERGDSGGVGVAQVGEFGLIDRVTARLSYGSTVLLGPGDDAAVVTAPDARVVASTDVLVDGRHFRRDWAGAHDIGRRAAAANLADVVAMGAEPTALLVALCVPADVETGWVEQLADGLGAEAASVGASVVGGDMSASPTLTIAVTALGDLAGRSPVTRAGARPGDLVALAGRTGYAAAGFTVLSRGFRTPRLLVEAYRRPEVPYAAGPAAARLGATAMIDVSDGLLADLGHVAKASGVAIDLRRDAFEVPPQMRDAAQALGVDPYAWLLAGGDDHALVATFPSQTVLPDGWREVGRVAEGRGVTVDGAPFDGPTGWDHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAR2</accession>
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            <fullName evidence="2">Nitrate/sulfonate/bicarbonate ABC transporter periplasmic protein</fullName>
        </submittedName>
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        <name evidence="2" type="ordered locus">VAB18032_17875</name>
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        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44677.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309200" evidence="1">
        <location>
            <begin position="24"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="33586" checksum="9DA19C015092EF70" modified="2011-06-28" version="1">MKMRTLRVAAAALLITVAGAACAENQTADGSGGSAAEPSANVTFGVGVDPAYSPIYLADQDKLFAASGVNVTVTQFQEGTGGLDAILAKQGQFTASTESSLLNRATRGDIKGLAVFSQSPSFIKLVARDGISDVTGIKKYGVVPGTVNEYATNKVLAAKNISRDSVEFVNASPAEMPALLQRGDVDGYIMWEPWPSRGVANGGKILLTSGDIGYVYNLVIGVDGAWYEANKDAAKKVVDTIGKACDQLTADPAKAGSVTEKAIKVPAAEAENLLKGVECKVRDFTDEDLKRYAEIAQFQQDSKIVEKAADPATVMIRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAY1</accession>
    <name>F4FAY1_MICM1</name>
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            <fullName evidence="2">Roadblock/LC7 family protein</fullName>
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    <organism evidence="2 3">
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        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="VAB18032_24230"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="NQVIVEM"/>
    <dbReference type="OrthoDB" id="1805380at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="13948" checksum="8B9E755FE31256A9" modified="2011-06-28" version="1">MPSALIADNLGRALDDLVDRVPGAQFAVVLSPDGIMLGTSRGIDGELAEQLSSMVCGLQALGTAAARVCGEGELHQVVIHMSRAFLFHATTGNGAILTVGIDAEAEVGDMAYEVAMFVAQAGDHLPVYLEPAVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAY6</accession>
    <name>F4FAY6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24255"/>
    <dbReference type="EnsemblBacteria" id="AEB45949">
        <property type="protein sequence ID" value="AEB45949"/>
        <property type="gene ID" value="VAB18032_24255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24255"/>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104911_1_0_11"/>
    <dbReference type="OMA" id="ANPCAWM"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="158" mass="16570" checksum="1FB9F8074E195834" modified="2011-06-28" version="1">MPDIVELLASPAHRFVGRPADGPAPAPAGELVEQVALRAELGIVGDRYFGKPAHREASVTVIAAESLPPGTGLAQVRRNILTSGIAVDELVGTVLVLDTGQGPVRLRVNRPAHPCAWMDVTVGPGAWRGLRGRGGVRCTPLTDGVLRVGPVDVQIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB90</accession>
    <name>F4FB90_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00755"/>
    <dbReference type="EnsemblBacteria" id="AEB47235">
        <property type="protein sequence ID" value="AEB47235"/>
        <property type="gene ID" value="VAB18032_00755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00755"/>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079636_0_2_11"/>
    <dbReference type="OMA" id="AFPVWSY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309212" description="DUF4142 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="31"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24140" checksum="1BD280B6B06F5C86" modified="2011-06-28" version="1">MAVLLTTIAAALVVLPGMALAAPAGQQLAAADQALLDGVRLAGLWEMPAGQMAAEKGQSRVVREIGAEIARQHEELDRLTVEAANKLGATIPNQPTAEQQQWLTEMKDATGARFDQIFVTRLRVAHGKIFPVVSAVRASTRNDVIRDLANATNKFVGDHMLMLESTGLVRYAELPPAALPAPGNDGLIAAASANTGPQIGISNTVIWVVFLGAIGTGGFLSYRLLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBE7</accession>
    <name>F4FBE7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730916.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05585"/>
    <dbReference type="EnsemblBacteria" id="AEB42243">
        <property type="protein sequence ID" value="AEB42243"/>
        <property type="gene ID" value="VAB18032_05585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05585"/>
    <dbReference type="eggNOG" id="ENOG5033VJV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138604_0_0_11"/>
    <dbReference type="OMA" id="RAMITRV"/>
    <dbReference type="OrthoDB" id="1525404at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="162" mass="18155" checksum="74B70EBA2393420E" modified="2011-06-28" version="1">MTSERETVEVEPALFQAVYDSPASLPGRHRWTTPETDVRRIEKLLGMPPRTIGAPLWVSGDQPDCPKCDRRITWYDIVSSALKGVHDPTMIATVILGERRYVNTGLPDAIAGVRCADCRTPIEGLRSFKCHNWAYAFEELTAVRERMAGGSLLGEQRRMPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBS0</accession>
    <name>F4FBS0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_18090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733375.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18090"/>
    <dbReference type="EnsemblBacteria" id="AEB44720">
        <property type="protein sequence ID" value="AEB44720"/>
        <property type="gene ID" value="VAB18032_18090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18090"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_1_0_11"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="746"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="308"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="873" mass="88195" checksum="1027F471F0FA0722" modified="2011-06-28" version="1">MAGVRILWLITRRTVAERWPRLVGTIAAGALATGLLAGSLQFILQFAAATDDVGGSEYATVSLVARPGDAPVRGPESGSGARVSAATVEQVAALPGVVAAAGDAAVPAEIVGAEGRVVAPPVGGGSHLRPWIAAPQLSPYALVAGRAPEAADEVVIDRQTARGGDLRPGDVTVLLLPDEAIRVTVVGVVTVGGGDGSVSGLTVLTEPARVRRTAGLGDDWQALWVAAAPGIDRAALATRVRDVVAGANPDAQVWVGTGAEVQASQRRTLAELAAQITTNLGMLALVGAFVGVFVLAGTFGTLARQRSRELALLLTVGMTPRQVRLLLRAEAVVVGLAAGLLGLLLGLGVARLLAASLAGTGLDTGGVGPQLGLAYLLPPLAAGLLIAWSASARPAWRASLAPPVESLAASSADPSGRSRRRLVAALPVLALAGMFVALSFLARREDPTPQGVTSAGAAAILAGLLLLSALAVLGPYVVPPLGRLVGALAVTLRPDVGRMARAFIVRSPRRVAAAASLLMLTVALATVTWSLVTSITEGRADRGTVAVRADLVVSTDGGSGLPASVAADVAAVAGVRESADLVRARTTVTDPIPPPRVRGRPTVVPPLAVTGARGAAVATLVDLGAAGPPVSRLTDGQIAVAAELAEAYDWPVGTRLTVRDAAGVQSLEVVATYSPEAQVMLGDALVSPATIRAIDPVAFVSAVLIAGPGPVADGLREAVADVPTARIDPPRAYLTGPGGGLVFDPMLLYVFLGVAIVTALFGVATTLSLSVAERTREFGVLGAVGAAERQIQALVRWEAATVVVLGTGLGVTTALGVVRLAQVVTDSDLIAARLPGYALPVIVLGAVAVTLLASVLPGRRAARVPVLLAVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC21</accession>
    <name>F4FC21_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734671.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24605"/>
    <dbReference type="EnsemblBacteria" id="AEB46019">
        <property type="protein sequence ID" value="AEB46019"/>
        <property type="gene ID" value="VAB18032_24605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24605"/>
    <dbReference type="eggNOG" id="ENOG502ZF4V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2686792_0_0_11"/>
    <dbReference type="OMA" id="GAYMIGS"/>
    <dbReference type="OrthoDB" id="2101387at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="74" mass="8092" checksum="7B54B2AFD114CFDE" modified="2011-06-28" version="1">MIDQHRHASAETAATPDNDRNLLRPVLWLLLILSAAANITMSVIGAYMIGSGFGLITVACTVALVVHHYRHRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCW8</accession>
    <name>F4FCW8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18490"/>
    <dbReference type="EnsemblBacteria" id="AEB44800">
        <property type="protein sequence ID" value="AEB44800"/>
        <property type="gene ID" value="VAB18032_18490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18490"/>
    <dbReference type="eggNOG" id="ENOG50301BZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130269_0_0_11"/>
    <dbReference type="OMA" id="VIAHWAE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="184" mass="21046" checksum="CD9051484D1C83EC" modified="2011-06-28" version="1">MIGAINEAHHRAVLGLYMVIVLAHWAEHLVQAYQIWVLGWARPQARGVLGMPFPWLVSSEWLHYGYAIVMLIGLFALRPGFVGRARTWWTIALAIQFWHHIEHLFLLLQVQAGFLLPGTSVPTSFAQLLIPRVELHLFYNSIVFLPMLVAMYLHLRPNEQELQLQRCNCTLEGRQRLAATNSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD83</accession>
    <name>F4FD83_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25075"/>
    <dbReference type="EnsemblBacteria" id="AEB46113">
        <property type="protein sequence ID" value="AEB46113"/>
        <property type="gene ID" value="VAB18032_25075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25075"/>
    <dbReference type="eggNOG" id="ENOG5030GDY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088150_0_0_11"/>
    <dbReference type="OMA" id="YRPDDRF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="233" mass="24525" checksum="8D37F15A9DC0B72A" modified="2011-06-28" version="1">MLATLDPKDLARPTGCVPWTVAELLAHVRTGAGRLIDMLAAPAPNGALVDAAGYFGAAKFTTEVDAARIESARAESARIESARIEAARAGDGRVEGGGERFGSDGTRRGVGLGEDFDRAWRAALAAVEANPPDRVVRTRHGDAMTVTEFLRTRVVEVGVHGLDLAAALDRPPWLTTAASRVIADLLTAGRFLPAELGWDRLTLIAKVTGRTPCSPAEQAALARVGLPLLAFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDE5</accession>
    <name>F4FDE5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01360"/>
    <dbReference type="EnsemblBacteria" id="AEB47356">
        <property type="protein sequence ID" value="AEB47356"/>
        <property type="gene ID" value="VAB18032_01360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01360"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_1_0_11"/>
    <dbReference type="OMA" id="PPEFEGH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="4">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="27843" checksum="3DD781119C6BB200" modified="2011-06-28" version="1">MTPEEAGRRLVALLAPVEATATVSGGQAHARATVDVPAFRWRAALLAARDDAELACDFFDWLSAVDELAEGFDVVVHLWSTTHRHGLLLRARVPRATPTIDSVVSVYPGAAWHERETHEMFGIDFAGHDDLRPLLLPPEFEGHPLRKEFVLASRVAKPWPGAKEPGESEAGGGRRPIRPPGVPTPGEWGTTPTPAGAGGAGEGPRGGTPARPARERPARPAPGARTPRTPPTPGAPASPEAGATPAPAGDGPATHVEGGQPDEGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDG4</accession>
    <name>F4FDG4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01455"/>
    <dbReference type="EnsemblBacteria" id="AEB47375">
        <property type="protein sequence ID" value="AEB47375"/>
        <property type="gene ID" value="VAB18032_01455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01455"/>
    <dbReference type="eggNOG" id="COG2813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031012_0_0_11"/>
    <dbReference type="OMA" id="CGYETKV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="198"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="434" mass="47147" checksum="06A7B1F0832E5521" modified="2011-06-28" version="1">MPEPLDAALAEVRSMLLGAGLTRAVAAGRRRGQRPSVVRAELRPVALKAGSRLQIVTSDGARPYTRNVAPGPESDVAVEALLAEPFGNWHVETTDLTLQLRVTKSGEAQVHRRRTAPPVQANGDQPGAQQQVGTTQGRQLAETAERQQQAAGVTERWQQEPASQQSAVAVPGGHDRAKAYLLDPGDPIFAEIGGSAAKRRQVDAFLRALAATLPGELTGPLRVVDLGCGNAYLTFAAYRYLSQRGLDVELVGVDVREDQRRRNTELAERLGWADRVRFVAGSIADAVVEPAPDLVLALHACDTATDEALARAVRWGARWVLAAPCCHHDVAAQLRAGGTPAPYGLLTRQGILRERFADVLTDALRAGLLRLHGYRAEVVEFVESAHTPRNLLIRARRTGAAPTRDQQAEYRQLVEQWRVAPRLETLLSQKPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDH4</accession>
    <name>F4FDH4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01505"/>
    <dbReference type="EnsemblBacteria" id="AEB47385">
        <property type="protein sequence ID" value="AEB47385"/>
        <property type="gene ID" value="VAB18032_01505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01505"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="QITNIFH"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="26366" checksum="56432D82186C1F9F" modified="2011-06-28" version="1">MLATRGLTWRIGEVAIVDAVDIDLAPGEFLGVIGPNGAGKTSLFNLITGLRRPTEGQVTLDGQDISTLPPHRRARLGLGRTFQASSVFGSLSVRENVRLAVQAHRGGSMKLWRRAVADREVAAAADAALDRVGLTHRGTALAGTLAHGEKRKLEIALLLAGEPRVMLLDEPMAGVSAEDVPELVQVIRSLTGDSGRSVLMVEHHMDVILELADRIAVMHHGALLACDTPETVMANPTVQEAYLGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDV6</accession>
    <name>F4FDV6_MICM1</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12615"/>
    <dbReference type="EnsemblBacteria" id="AEB43637">
        <property type="protein sequence ID" value="AEB43637"/>
        <property type="gene ID" value="VAB18032_12615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12615"/>
    <dbReference type="eggNOG" id="ENOG5031MNQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075797_1_2_11"/>
    <dbReference type="OMA" id="WRTRNPG"/>
    <dbReference type="OrthoDB" id="1899949at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010219">
        <property type="entry name" value="UCP010219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="24139" checksum="F17BCA1B7234CD16" modified="2011-06-28" version="1">MTTGQQPATQPDTGPGDEERLPTVAEQMADQLGGWRGLVESSIPVVVFVVVNIVGALRPAVIASVGVAVLIGGLRLAQRKPVRHAVNGLFGIGIGAAIAWRTGEARDFYLPGILYGIGYGLALLASAAIRQPLVGWLWSVLVAKGSSAWRDDPKLVRTFTGLTVLWGVVWLAKVGVQAALYLAEQDTALGVARLALGYPPYVMLLLITVWTVRRVTRNNEPTPLPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDZ6</accession>
    <name>F4FDZ6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_18815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733520.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18815"/>
    <dbReference type="EnsemblBacteria" id="AEB44865">
        <property type="protein sequence ID" value="AEB44865"/>
        <property type="gene ID" value="VAB18032_18815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18815"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_2_11"/>
    <dbReference type="OMA" id="IGYRPAS"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB44865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="27059" checksum="8E9FB29F2143E512" modified="2011-06-28" version="1">MTLPLAVAAPRRTPTPVVLAAVRRSTRAVLRSPALLVAPVAQSLFFLLVYAGQLSTVGSSYLPGTGFIAFLLPLILLTGVATGAGAAGTLVLRDITSGYLDRLRLAHGSTTPFLVGPVGAALVAVVVQMVITVVGATVIGYRPQSWPGVFTMLLLLVALGLGVALLSTALAIRSASASTTGLVPLAVFGLSFFTGVFAPVDELATWMRLIATVNPLTYIVETARQLGSGDTLTAAPVGVTAVAFLAVAGIVACALALRNARKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE02</accession>
    <name>F4FE02_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine aldolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733526.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18845"/>
    <dbReference type="EnsemblBacteria" id="AEB44871">
        <property type="protein sequence ID" value="AEB44871"/>
        <property type="gene ID" value="VAB18032_18845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18845"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_4_0_11"/>
    <dbReference type="OMA" id="WRHRYGG"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="40698" checksum="EF1F5DA2D960DE2B" modified="2011-06-28" version="1">MNAEPRTPQDSGRRPVTTTGRTVRRSLVLHSELHRRPQEMLRAMLAQVDADTPPHGPDGPVAALERRIAALLGKEEALFFPSGTMAQQVALRIHADRRGRRAFAAHPQSHLEVWEHRGYAVVHGLHCHPAGDRHRLMDHDDLVAVGEPLAAVVWELPQRDIGGQLPQWDDLVAQTTAVRGRGAATHLDGARLWEAQTYYARPFAEIAALFDTAYVSLYKGLQGTGGAVLAGPADVLAEARTWRRRLGGDVYDAWPLALAALHGLDTRLPRLPVYRDHALVIAAAITADGVARVVPDPPQTPLFHIHLPVGPAAAERAAAALLAETGVELFRRTWSAPDPHRCAFEVTVGENAMAFTPEEVVDLLHRLLRYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE03</accession>
    <name>F4FE03_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xaa-Pro dipeptidyl-peptidase</fullName>
            <ecNumber evidence="3">3.4.14.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">X-prolyl-dipeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_18850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes Xaa-Pro-|- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-|-p-nitroanilide and (sequentially) Tyr-Pro-|-Phe-Pro-|-Gly-Pro-|-Ile.</text>
            <dbReference type="EC" id="3.4.14.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.11" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18850"/>
    <dbReference type="EnsemblBacteria" id="AEB44872">
        <property type="protein sequence ID" value="AEB44872"/>
        <property type="gene ID" value="VAB18032_18850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18850"/>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011800_1_0_11"/>
    <dbReference type="OMA" id="AMEGVSY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008252">
        <property type="entry name" value="Pept_S15_Xpro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00923">
        <property type="entry name" value="LACTOPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309285" description="Xaa-Pro dipeptidyl-peptidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="10">
        <location>
            <begin position="378"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB44872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="614" mass="66329" checksum="3F39701147B814D0" modified="2011-06-28" version="1">MTGALVLSASPVAAKPAPASTTPGIVVSDGMTQPVFSLADAIEERVYVETPVDTDGDGRRDRVAIDISRPRETATEGFKVPVIFEHSPYRKGTWGSVPYHSVLVDELPQNGVTHPSVSLSADVETQGAVTKPNLPGQLDDYYVPRGYAVVLGQSVGTGDSDGCPTSGDQAETLGTKAVIDWLNGRAKGYDANGAPVKADWSTGAVGMTGASYNGTLPNQVATTGVKGLKTIVPVAAISSWYDYYRANGLVVAPGGYQGEDADILAKYTAGRARAEGHCADEMAKLTEEQDRVTGDYSKFWADRDYLDAKKVKASVFVVHGLNDWNVRTEQFAGWWDELAKHKVPRKLWLHQGGHSSPGNTAAVTLPDGQTWTYKQTENRWFDFWLWNVPNGIMDEPTAVVQREDRVNTTYANWPDPATRDVKLALGATDATSPGTLIAGKRPKDATVEQSFVDNGRTLSPNALVATPDAANPNRLAYLTPELTQDVRISGRAEMRLRMAIENKSAANLTAYLVNYGPAGSTAAPTVVTRGWLDPQNRKDAARTEPLKQGKLYDLKWTLEPKDYVFPAGNRIGVVVFSTDQAYTLLPLGGTELRVAPKHSELRLPVVGGQKALAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE13</accession>
    <name>F4FE13_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18900"/>
    <dbReference type="EnsemblBacteria" id="AEB44882">
        <property type="protein sequence ID" value="AEB44882"/>
        <property type="gene ID" value="VAB18032_18900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18900"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014010_0_0_11"/>
    <dbReference type="OMA" id="ADIMVNS"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="766" mass="81157" checksum="7F739CEE7C59E018" modified="2011-06-28" version="1">MEPQVAAGQAQPETVRLGLRMLRDYHRPTLARMRALLRSMVTSFVVLSATFWLLPGVTTTGLVGLLWLVGLVTAVGAVLRPLLLALATALGGLGALAIGVGVQALVMYVALRLAPEAHVAGFPVAFAAAWLAVALAAMVNWLADAGTDDSFVSEMLRLMSRVRRSLDGRPRWRPWRRAAATSTEDAEPAAGLLIIQLDGVAAPVVQWAVRAGNLPTIGRWLRSGSHRMTRWHTGLPATTPAAQAGLLYGEVDHVPAYRWYEKATADGEPGRLVVTSRPRDAAEVERRVSTGRGLLRDGGVSISTAFSGDAPTSLFTISRAGLPGRSTPGYAAFMTSPYGFARAVVLGAGQVLRELHGARRRRVRGVQPRADRGGSYLAVRPLASLLSDLNVALIAEQMARGAPVIFCDFVDYDEVAHHAGPARPEAMAALETLDHTLGILHRLTAEGARRYHVVVLSDHGQSQGATFRQRYGESLTQLVRRLTATQEILPAPVDDEPGGRPETWERVDRLLTEVTGRSGMTATATRVAARSATGTPAAADPAPAVDHNEPETVVVASGNLAMIYLAHHPGRLTRDRVDAVAPGLIDGLTAHPGIGLVVVDSAAGPLAIGARGVHRLSDGQVDGDDPLTPYGPRARHDLLRHQQMAHVGDLVVISAVEPGLEEVPAFEELVGSHGGLGGWQNEAVLIHPADWPQQGELVGPDAVHRQLLGWLHRLGLRQPDNPASPANPTSLTSPTSPTGPVRPAEPVTLVAEPTAGVGVPTSPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE51</accession>
    <name>F4FE51_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_19090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733575.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19090"/>
    <dbReference type="EnsemblBacteria" id="AEB44920">
        <property type="protein sequence ID" value="AEB44920"/>
        <property type="gene ID" value="VAB18032_19090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19090"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_11"/>
    <dbReference type="OMA" id="SPWRDFL"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="32336" checksum="1EE1521EB9824C7B" modified="2011-06-28" version="1">MTTIAPDPVAPDPKVDRALSRRRWLGRLRGGGTRPVWRQPVTLAALVILGGWLLVAIFAPLIAPYDPLAQSPDAYASPSAAHWFGTDSLGRDILSRVIHGARLSIPLALAIVSLALLIGGLLGLLAGYLGRLADEALMRLTDLVFAFPQIILAMAVTAAFGPNTRNAVLALVIVSWPVYARVIRSAVLSMRGDDYLNAARLLGVGPVQALRRDVLPNSIGPAIVLATLELGNAVLLLAALSFLGLGPRPPAAEWGSMVALGSQDLSMWWVSVFPGLAILTVVMAFNVLGDALRDRLDPRYAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEJ5</accession>
    <name>F4FEJ5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ordered locus">VAB18032_01765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736072.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01765"/>
    <dbReference type="EnsemblBacteria" id="AEB47437">
        <property type="protein sequence ID" value="AEB47437"/>
        <property type="gene ID" value="VAB18032_01765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01765"/>
    <dbReference type="eggNOG" id="COG0181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_1_0_11"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="1450400at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="10"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="230"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="336" mass="34727" checksum="6DBAB1E4B5E06E26" modified="2011-06-28" version="1">MSQRQPSGPLRLGTRGSKLAMAQSGHVAEALTARTGRPVELVEVITAGDRSSAPVHRLGVGVFVSALRDALVAREIDFAVHSYKDLPTAMPAGLHIAAVPPREDPRDALVARDGRTLAELAPGASIGTGALRRIAQLHALGMQLSVSPIRGNIDTRLARVLGPDADLDAIVLARAGLARIGRLDVITETLDPMLMLPAPAQGALAVECRVDDPEMVELLGTLDHAASRATVTAERAMLATLEAGCSAPVAAYAVVAEGEPTGSGVEGDVVQEIYLRGAVISPDGSRDIRLSRTGTLADAAEIGKALATELLDLGADSILGPQGHNGPGTQQFGSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEJ8</accession>
    <name>F4FEJ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736075.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01780"/>
    <dbReference type="EnsemblBacteria" id="AEB47440">
        <property type="protein sequence ID" value="AEB47440"/>
        <property type="gene ID" value="VAB18032_01780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01780"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_2_11"/>
    <dbReference type="OMA" id="HIVWDWN"/>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="23747" checksum="34D4244498544881" modified="2011-06-28" version="1">MTPSKPHLVWDWNGTLLDDLSLVVACTNAVFTREGGPTVTAEEHRVRFRRPIADYYAEVLGRAVDDEAFGRLDRIFHDAYRLGLTSCELAHDAVDAMAAWPGSQSLLSMWFHDELVPAIQTYGLTGRFARVDGLRASVGGDRKAESLVRHLAELGVDGRSVVLIGDSLDDADAARAVGGRAVLYAGGFTDRARLMASGHPVADTLTEAVTLATTLVEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FES8</accession>
    <name>F4FES8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 7">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_06740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06740"/>
    <dbReference type="EnsemblBacteria" id="AEB42472">
        <property type="protein sequence ID" value="AEB42472"/>
        <property type="gene ID" value="VAB18032_06740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06740"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_4_1_11"/>
    <dbReference type="OMA" id="GHEGCGA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="232" mass="23634" checksum="9558B67285F58B6B" modified="2011-06-28" version="1">MSRPGPIGTELRPERELLTADLPGAPQLALAELMAGNRRFVTDTAWHPNQNAGRRAAVAGEQHPFAVIVGCSDSRLAAEIIFDRGLGDLFVVRTAGHTVGPEVLGSVEYAVSVLRTPLVVVLGHDSCGAVQAARAALATGAAPTGHLGAVVDAVVPSLRQAQAAGVNDLNEIVDIHIAQTVTAMLGSSATLAAEVSAGRCAVVGMSYRLAAGEVRAVAAEPAELVAELASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FES9</accession>
    <name>F4FES9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06745"/>
    <dbReference type="EnsemblBacteria" id="AEB42473">
        <property type="protein sequence ID" value="AEB42473"/>
        <property type="gene ID" value="VAB18032_06745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06745"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073856_0_0_11"/>
    <dbReference type="OMA" id="GRACDWS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307675" evidence="2">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="35802" checksum="D554D63B353542B7" modified="2011-06-28" version="1">MVAVFAAFAVFAGPLPAAAAPKPPKPAGHDDDPPMLNELIEATNRDYTKAKSKLEKSKKKQLKLAVEVRRAEADLDALAPQVAEIATQSYRTGRVGAIAMLLQSNAPDSFIHRAAALDELNLVNSKKLGEVNAVKRRAETAKLALDAEVREQQKLTNDMARKKSDAEKSLRLVGGVGLTGGLVAATSPVARPGPNRAADGGWKPESCNQNDPTTSGCITARTLHMYKEVKRAGFNRFVGCYRPGDKWEHPKGRACDWSLQNSGFRPWYNNDTRIYGNNLAAFLVRNADRLGVYYVIWNRQIWFPATGWSSYSGPSNHTDHVHVSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF53</accession>
    <name>F4FF53_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733613.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19280"/>
    <dbReference type="EnsemblBacteria" id="AEB44958">
        <property type="protein sequence ID" value="AEB44958"/>
        <property type="gene ID" value="VAB18032_19280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19280"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_3_3_11"/>
    <dbReference type="OMA" id="TARWFGP"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="19212" checksum="C748559740D0BB37" modified="2011-06-28" version="1">MTPTPTGRLFGADRGTDLVITREFRAPVEDVWASLTEPDRTARWYGRWDGHAAPGRSIRVQMAFEEGQPWSELRIDACEPPRRLALSSQDEAGAWRWEVQLTPHGERTELRFVQHLDTVEGIGEIGPGWEYYLDRLLAVHNDTTMPSFDDYYPAMKTYFDQLSLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF99</accession>
    <name>F4FF99_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylose abc transporter, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19510"/>
    <dbReference type="EnsemblBacteria" id="AEB45004">
        <property type="protein sequence ID" value="AEB45004"/>
        <property type="gene ID" value="VAB18032_19510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19510"/>
    <dbReference type="eggNOG" id="COG4213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_13_1_11"/>
    <dbReference type="OMA" id="SARWIDD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="359" mass="37918" checksum="99428F6CB6E53B46" modified="2011-06-28" version="1">MAACSGDGAGGGGNDSDKPGDLTIGVSMPTQTSERWIADGNSVKEKLEAKGYKVDLQYAGDDIPTQSQQVDQMITRGADVLIIAAIDGTALSGQLQAAADAKIPVIAYDRLIRDSPNVDFYVSFDNFKVGVAQATALLVGLGLQTKDGGKGEATGPFNIELFAGSLDDNNAHFFFNGAMETLKPFIDAGTLKVKSGQTKIDQVAILRWQQEGAQKRMEDLLTSSYNDGSKVAGVLSPYDGLSRGIITALQNAGYSGDMPVVTGQDAEIASVKLINDGVQSSTIFKDTRLLAEQAVVAGESFLQDKTPQANDTETYNNGVKVVPSYLLPVQTVFKDDIKPVLIDSGYFTAEEVAAGQAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFB4</accession>
    <name>F4FFB4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733674.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19585"/>
    <dbReference type="EnsemblBacteria" id="AEB45019">
        <property type="protein sequence ID" value="AEB45019"/>
        <property type="gene ID" value="VAB18032_19585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19585"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008033_2_0_11"/>
    <dbReference type="OMA" id="LYNFRAN"/>
    <dbReference type="OrthoDB" id="194265at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307868" evidence="1">
        <location>
            <begin position="36"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="588"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="730"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="862"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="913" mass="98561" checksum="C0F4A3C6E729C3E0" modified="2011-06-28" version="1">MPYPSLNRRHILQAAGAAALATAVGPVLRGGTASAAIPPVRPDLGVAAYAFDMGQVRLTASRWLDNQNRTLNYLRFVDVNRLLYNFRANHRLSTAGAAALGGWEAPTFPFRTHSQGHFLTAWSHMWAVLGDTTCRDKANYMVAELAKCQANNAAAGFNPGYLCGYPESDFTAVEARTLNNGNVPYYTIHKTLVGLLDVWRHIGNNQARDVLLALAGWVDWRTGRLSSAQMQAMLGTEFGGMNAVLTDLYQQTGDARWLTVAQRFDHAAVFNPLAANQDQLNGLHANTQIPKWIGAAREFKATGTTRYRDIASNAWNLTVNTRTYAIGGNSQAEHFRAPNAISGYLRNDTCEHCNTYNMLKLTRELWLLDPNRVAYFDFYERALLNHLIGAQNPADNHGHITYFTPLQPGGRRGVGPAWGGGTWSTDYNSFWCCQGTGLENNTTLMDSIYFHNGSTLTVNLFMPSVLNWSQRGITVTQSTSYPASDTSTLTVTGTVGGSWTMRIRIPAWTQDATVSVNGTVQNIATTPGTYASLTRTWTSGDTVTVRLPMRVVVEPTNDNPSVVALTYGPAVLSGNYGNTALSALPALATASVTRTSSTALTFTATANNTQVNLLPFYDAHGHNYTVYWSSGGSSGPAQATFRLVNAASGLVLGIENMSTADGAPALQWADNGTADHDWQLIVDGSVVRFRNANSGKVLGVQNMSTADNAQVLQWSDTGTADHRWTIVDAGDGSHKIRNGNSGKLLAVLSGSTAQGARVVQDPDNGTPDNQWRFVPNGARRIQNLATGLVLGVQNMSTADGGLVIQWGDTGTADHLWTAIVDSGGYLRLRNSNSGKVLGVENGSSAAGARVVQWTDNGSAAHRWRLRYGGGGYFRIQSANGGRVLGVLGASSSQGTQIVIWDDNGANDHRWRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFP1</accession>
    <name>F4FFP1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736152.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02170"/>
    <dbReference type="EnsemblBacteria" id="AEB47518">
        <property type="protein sequence ID" value="AEB47518"/>
        <property type="gene ID" value="VAB18032_02170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02170"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_11"/>
    <dbReference type="OMA" id="FINYCQY"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="322" mass="34184" checksum="600E05B53D6B035D" modified="2011-06-28" version="1">MTRWGILATGHIAARFAEDLRLVPGAELVAVGSRTAESAQRFADRHGAARAYASWADLAADTDLDVVYVATPHVAHYEAARTCLAAGRAVLLEKPFTLDLPTSTELVDTARAAGVFLMEAMWMRCNPLILRVCELIADGAIGTVTSVRADFGLAGPFPPEHRLRARTLGGGALLDLGIYPVSLAHLLLGVPQHVRSWAKLGPEGTDENTGLVLGYDSGAIATLSCGLVGATGVTASITGTAGRIDLPEPFFRPEAFHLHREGAETETFTAELVGSGYQYEAIEVQRCLAEGLTESPLVPHSATLEIMGLLDEVRAQIGVSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFP9</accession>
    <name>F4FFP9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02210"/>
    <dbReference type="EnsemblBacteria" id="AEB47526">
        <property type="protein sequence ID" value="AEB47526"/>
        <property type="gene ID" value="VAB18032_02210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02210"/>
    <dbReference type="eggNOG" id="COG2339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029195_1_0_11"/>
    <dbReference type="OMA" id="LVIWTRQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="455" mass="49714" checksum="E3C027D1877DD9E2" modified="2011-06-28" version="1">MPRRRLGWRRALVLSGAILLIAACAIFMLFTLGTNLGTEALLIGAAAAILPVPVLVACFLWLDRYEPEPLKYLIFCFGWGAFVSTAASLLVNETAAGWFEDQGLPVALTAVLVAPFIEELTKAIAPILLLVFRRREWSGITDGLVYCGLSAIGFAMVENILYLGGHGYASGAEQYGPATGAQQVIAIFIVRILLFGFAHPLFTAMTGIGLGIAARTADRRVRVFAPIAGLLLAMMLHGAWNLIPTLTQATGQVLISLFGFVGVMVPIFFGMVGLAVWLRAWEGRLTERILPDYVRAGWLTPPEVAALSSLGRRHAARAWARRVAGDAGLRAMRGYQFAATRLALLRDGSLRGLDRRPVDRERTAREERELLDSISVYRSFFVGRDPQTPVGVWDGHRYHLRFPDGSKRTVDAPEDPVVPIPVVLAAPPPPAPYPGHHPPPGWYGPRPVTPWPPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFS1</accession>
    <name>F4FFS1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736181.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02320"/>
    <dbReference type="EnsemblBacteria" id="AEB47548">
        <property type="protein sequence ID" value="AEB47548"/>
        <property type="gene ID" value="VAB18032_02320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02320"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013104_0_0_11"/>
    <dbReference type="OMA" id="WIAGGHD"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="652"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="685"/>
            <end position="692"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="954" mass="99473" checksum="04BAD6A6E0F67206" modified="2011-06-28" version="1">MKSPISAARLRRALPTGRRAVAVSVAVVLLAAVVVWAAWPDRPGFRTESAMLTVASGPSGNEPVDLDTTLYLPNDAEADRKVPAVLLAHGFGGTKNSVRTDAEELADRGYAVLTWTARGFGRSGGQIHLDNPDYEVRDAQRLLDWLAARPEIRTDGDGDPRVGVVGGSYGGGLALLLAAQDQRVDAIVPMITWNDLSRAFLPESTGGEPTRGVFKSGWAGIFFGGGGNVGSGPAGISGNTAEAPEGAPAPGPPSPAPGQGPGTAPGAPTTAAIPDPACGRFAPDVCAAYLSIAVTGQADQAAVDLLRRSSPAGVLDRIKAPTLLVQGAADTLFPLGEADANARGIAANGTPVRVAWFTGGHDGGAGPRTDSDRVKFLTAQWLDHYVAGTAATPGDSFTFSRIAGFDALDRGLVATGYRTTDYPGLNGQSRQEVALAGPPQPVANPPAGNPAAISSVPFAGSLSSLLSGVAADIPGQHARFDSEPLTEAVDVVGSPTVQIRAASPTGEAVLFAKLYDVNPEGAATLPSGLIAPIRLTGLPTQVAEATPVTVTLPAIVHRVEAGHRLRLVLATSDQAYTTPVEPTVYQVAATGPVSLPAVDAEPIPTEAVLWRWILVGLLAAIVLGLVVLVLLLRLRHRRQDTSVHPEYADTPLAVRHLRKEYADGFVAVSEVDFEVHPGQVVGLLGPNGAGKTTTLRVLMGLTQPTAGEIYVFGHRLVPGSPVLSRIGALVEGPGFLPHLSGLENLKAYWRATGRPEADAHFDQALEIAGLGSSVHRKVRKYSHGMRQRLAIAQAMLGLPELLVLDEPTDGLDPPQIAEMRRVLQRYATDGRAVLVSSHLLAEVEQTCTHAVVVNKGRIVASGPVEEIVGDSPSVLFEVSDPAAAREVLADLGGVRVLDDTDGQLVVDTNGTARSEVVAELVRAGIGVDRVVPRRRLEDAFLALVGENSRGSGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFT0</accession>
    <name>F4FFT0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731183.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06930"/>
    <dbReference type="EnsemblBacteria" id="AEB42510">
        <property type="protein sequence ID" value="AEB42510"/>
        <property type="gene ID" value="VAB18032_06930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06930"/>
    <dbReference type="eggNOG" id="COG2343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059611_0_0_11"/>
    <dbReference type="OMA" id="VGHPHDP"/>
    <dbReference type="OrthoDB" id="2063459at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="150"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="29200" checksum="5A462511397B2055" modified="2011-06-28" version="1">MLAPAPRFAPPEDRLTYHHSERWVRGRIGDTVVVDSRRPLLVWEPGLPVPFYVFPLADLVGGTLRPAEQPPEPGSRAGSSFHDLTVDGVTLPNAAWTYPGDVFAQTVCLAWREWFGQGVERWYEEDEEVFVHPRDPFSRVDSLPSTRHVVVAHEGVVLADTRRPVLLFETGLPTRYYIPADDLVQELLLPSEHHTRCPYKGVASYWSLRQVPGAAGRNIAWYYPDPLPSVANIAGFTAFYPERVTILVDGESVSPPTPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFW3</accession>
    <name>F4FFW3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42543">
        <property type="protein sequence ID" value="AEB42543"/>
        <property type="gene ID" value="VAB18032_07095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07095"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_1_1_11"/>
    <dbReference type="OMA" id="RMAPMHW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="61"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="34102" checksum="D542F78D04E08248" modified="2011-06-28" version="1">MPGSRAVRKLIAEGGMKPDLSEVDQIPVQPAAELPHAGAGEVVATWVGHASFVLQIGGLVVLTDPVWSRRIPGVRPRFTPPGLPWEALPPVDAVVISHNHFDHLDAPTIRRLPRDVLMLVPGGLGWWFRRLGFTAVEELDWWESVRLGAVQFQFVPVHHWSRRTLFDGCQSLWGGWLLEADADPATAAPVRRVFFAGDSAYGPYFTEIGQRCGPVDLALMPVGAYLPRWFMKPLHMNPAEAVRACGDLGAQRMATMHWGTFALSAEAPLEPLRQARQAWQASGRAAEDLWDLAVGQSRTLHADLTAPVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG45</accession>
    <name>F4FG45_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732456.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13385"/>
    <dbReference type="EnsemblBacteria" id="AEB43789">
        <property type="protein sequence ID" value="AEB43789"/>
        <property type="gene ID" value="VAB18032_13385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13385"/>
    <dbReference type="eggNOG" id="ENOG5033AIJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192240_1_0_11"/>
    <dbReference type="OMA" id="GYTTLRQ"/>
    <dbReference type="OrthoDB" id="2056222at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="6877" checksum="B947A9E61FD550FF" modified="2011-06-28" version="1">MNSDLDTLPKISAPATRALHNAGYATLRDLVGVSRAELAELHGMGPKALGIIQSALEEHNLTLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG73</accession>
    <name>F4FG73_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732484.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13525"/>
    <dbReference type="EnsemblBacteria" id="AEB43817">
        <property type="protein sequence ID" value="AEB43817"/>
        <property type="gene ID" value="VAB18032_13525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13525"/>
    <dbReference type="eggNOG" id="ENOG502ZV3A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1591086_0_0_11"/>
    <dbReference type="OMA" id="AIWVRWG"/>
    <dbReference type="OrthoDB" id="1615659at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="19295" checksum="6DBEB2679FAD89FE" modified="2011-06-28" version="1">MGEEGRWLAERVDRLVFTDLSTDQVTALLVDTVVDWAQGRGWRVYRRAPSVLPLPPPMSAQQSVLDVACARPDGPPVVVEIDHGTRRRTWEKLLAEAEAGRIPLWLRWGTGRFAPPPPPIQMVTCEVTARPDPAGRGRVHSRLPRARMQPPAHSAVRLGEPAAVELPLPPAPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGF2</accession>
    <name>F4FGF2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase S11 D-alanyl-D-alanine carboxypeptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_19940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19940"/>
    <dbReference type="EnsemblBacteria" id="AEB45090">
        <property type="protein sequence ID" value="AEB45090"/>
        <property type="gene ID" value="VAB18032_19940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19940"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_3_0_11"/>
    <dbReference type="OMA" id="VYGMIVK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313906" evidence="11">
        <location>
            <begin position="27"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="12">
        <location>
            <begin position="83"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB45090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="420" mass="43326" checksum="10BECB0ECCE6615D" modified="2011-06-28" version="1">MFMDFRALATVVAVLATGIVPVTAGASVNTQGAAPVATPCPKAKAPKVLRSPRPTPPPPVAEHRVVGGDALATPGLVVPPQVPTPPKVTATSWVVADLDTGEVLGGCGPHEYATPASVQKLLLAATMLPRLDPAEVVTITAGDLDIEPGSSAVGLVAGGRYRIETLWLGLLLRSGNEVANALARLGGGADGMAGGLRAMNEQARQLGAYQTHAATPSGLDGPGQFTSAYDLALIARACFDDEHFRRYVATREADIPAQPKQRAKGFTIDNDNQLLYRYPGALGGKTGYTDLARHTYVGAAERNGRRLVVTLLGADVIDQRGWQQGAALLDWGFALPRDASVGVLVRPGATTASAPPSTMPAQALPGGASGGEATDRHPLADPLRSASYALLAVGLTVGVGALIGHRRRLRAAGRAPTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGL0</accession>
    <name>F4FGL0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_26235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26235"/>
    <dbReference type="EnsemblBacteria" id="AEB46345">
        <property type="protein sequence ID" value="AEB46345"/>
        <property type="gene ID" value="VAB18032_26235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26235"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="250" mass="27635" checksum="565B6B9DA6B15768" modified="2011-06-28" version="1">MVRAEQVHKSFGSIEVLKGIDLEVRAGEVCCLLGPSGSGKSTFLRCINHLEKINAGRIWVDGDLIGYRERGGKLHEMREKEVAAQRQAIGMVFQRFNLFPHKTALENVTEAPLLVRREKRAEVRDRAVALLERVGLGDKLGNYPSQLSGGQQQRVAIARALAMQPKLMLFDEPTSALDPELVGEVLDVMKDLARDGMTMIVVTHEIGFAREVGDSLVFMDGGVVVEQGNPREVIANPQHDRTKAFLAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGY5</accession>
    <name>F4FGY5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731272.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07385"/>
    <dbReference type="EnsemblBacteria" id="AEB42599">
        <property type="protein sequence ID" value="AEB42599"/>
        <property type="gene ID" value="VAB18032_07385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07385"/>
    <dbReference type="eggNOG" id="ENOG5030VH7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2285364_0_0_11"/>
    <dbReference type="OrthoDB" id="2212935at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="110" mass="11844" checksum="F10D1F216E7F87F4" modified="2011-06-28" version="1">MTDEIHRQPLARAVLAALARTRGGDDPLGSLARTVLHGEADLRTAAAHSWHGRALGDAFTASLTERATIPADQRAEWERQAQRLRDAGTALTVELTPPDGAAGDGREERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGY8</accession>
    <name>F4FGY8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07400"/>
    <dbReference type="EnsemblBacteria" id="AEB42602">
        <property type="protein sequence ID" value="AEB42602"/>
        <property type="gene ID" value="VAB18032_07400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07400"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_1_11"/>
    <dbReference type="OMA" id="WHEAADE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="66"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="29289" checksum="4D54B57510246CDC" modified="2011-06-28" version="1">MDWSLSKVTRIENGSVSISVNDLRALLDFYQVRDAGQVRDLLGLARLARRRHWAAEYREYVSASYMDFLGYEDDSWRISQYHPFLIPGLLQTERYAQLVVTIGPRYRGDEAAADARVQLRLARQARVFAQPQREVRIVLDERALKSVENTQLMLEQVEHILFRLPDHLHVVVLERDTAANSALVGPFSLHEFEWDVDPDVVYLDALPDDVALVEDEAAVAGYKASFEDLYRQAAKGDDAQRLLEEIRGSLREQTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH03</accession>
    <name>F4FH03_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731290.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07475"/>
    <dbReference type="EnsemblBacteria" id="AEB42617">
        <property type="protein sequence ID" value="AEB42617"/>
        <property type="gene ID" value="VAB18032_07475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07475"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082070_0_0_11"/>
    <dbReference type="OMA" id="DRVGYGT"/>
    <dbReference type="OrthoDB" id="1585236at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="84"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="157"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="25151" checksum="E845C6B24D52E985" modified="2011-06-28" version="1">MTTTTMARTDEQLQRDVLAEMHWDARVHPNEIGVSAKDGVVTLTGWVDSYVKKWAAEEAAHRVRGVKAVANDLEVRLPTAAERTDADLAAAATRALEWDALVPSQNIHVTVTKGWVTLSGEVEWEFQRRSAKRAVRRLSGVRGVTNQISLRPRVKVDVAAARDRIEEALIRAVDTPGERLSVTIEGDKVVLTGVVRSWREREEAARVAWSTPGVMSVENRIVVMPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH56</accession>
    <name>F4FH56_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732501.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13610"/>
    <dbReference type="EnsemblBacteria" id="AEB43834">
        <property type="protein sequence ID" value="AEB43834"/>
        <property type="gene ID" value="VAB18032_13610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13610"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_0_0_11"/>
    <dbReference type="OMA" id="RRGYDTR"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="39"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="245" mass="26536" checksum="7E6CEEEDE63B32C2" modified="2011-06-28" version="1">MLAGTTAAGFALHAVPALTSVAPVRRRLLPELSGIGRPGHVALTFDDGPDRRSTPRFLHRLDRADVRATFFLLGSLLDRDPGLGREMTAQGHEVAVHGWEHHNLLCRTPSATYADIARARDRIAELTGQPPRWYRPPYGVLTTAALLACARLGLQPRLWTAWGRDWRADATAGSICHDVLRTLRPGGTILLHDSDHVAAAGSWHATLTALPALIDWATQRNLTLGTLSDHQPVGARPVTAPPGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHD7</accession>
    <name>F4FHD7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_20035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733764.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20035"/>
    <dbReference type="EnsemblBacteria" id="AEB45109">
        <property type="protein sequence ID" value="AEB45109"/>
        <property type="gene ID" value="VAB18032_20035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20035"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_4_0_11"/>
    <dbReference type="OMA" id="RRYFRWD"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="27174" checksum="C6E3592CE691710C" modified="2011-06-28" version="1">MSAVTVVGGSVAVWRLEQRLFWRNRALVVPTFLVPVAMCVSIPFTVPAGLDWDGVPYRGHFLTAMIAMITVYSTFTTLVVTLTSRRDALILKRLRGTELPNRSILAGNVLTAYVLSGLQLVLLLTIGLLALGVPAPENPLLLMVALAYGTAVFAVLAAAYTALIPNAESAQILCIPVLFACFACSGIFVPLSVFPDWLRTIAELLPVTALADAVRAAFYGGGALPRDAAVLGVWWAVGVITTRRFFRWEGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHK4</accession>
    <name>F4FHK4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-Lysine 56-aminomutase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733831.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20380"/>
    <dbReference type="EnsemblBacteria" id="AEB45176">
        <property type="protein sequence ID" value="AEB45176"/>
        <property type="gene ID" value="VAB18032_20380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20380"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517447_0_0_11"/>
    <dbReference type="OMA" id="SGLCMPE"/>
    <dbReference type="OrthoDB" id="346908at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015130">
        <property type="entry name" value="Lys-AminoMut_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037086">
        <property type="entry name" value="Lys-AminoMut_asu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09043">
        <property type="entry name" value="Lys-AminoMut_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lys-AminoMut_A" evidence="1">
        <location>
            <begin position="5"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="519" mass="56525" checksum="09EF1D1E9A165D79" modified="2011-06-28" version="1">MTGKLDLDPVLVARARELARRAGRPVVELARSHTTVSVERAVLRLAGVTGADPDGIPWVNRLVDAVVADVGLGHGVAVPVFDALAREQITDVTLLAQKAAAGSVRFEVPSGKAATAARRVARRAVGAGVRLIDRRRVERERLVRRFGDPARRPWIYLIVATGDIYEDIPQAQAAARAGADVIAVIRSTGQSLLDYVPEGATREGFAGTYATQENFRLMRAALDSSSKELGRYVRLTNYASGLCMPEMATLAGLERLDMMLNDSMYGILFRDINPIRTFVDQRFSRQVHARAGIIINTGEDNYLTTADAVDEAHTVTVSQLLNEYFAHEAGLADWQLGLGHAFEINPDVPESLRLELAHALLARELFPDAPLKWMPPTKHMTGDVFRGNLLDGFFNLVGTMTGQGILLVGMMTEAVVTPWLSDRDIALQNVRYVLGAAGGLHEDFVPAPGGFIQQRAHRVLGEAVELLERIGDQSLLTAIAEGTFGIMKRPADRGKGLDGVARHEADYYNPATEILEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHM8</accession>
    <name>F4FHM8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 12">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpE</name>
        <name evidence="15" type="ordered locus">VAB18032_26601</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 12"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735048.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26601"/>
    <dbReference type="EnsemblBacteria" id="AEB46397">
        <property type="protein sequence ID" value="AEB46397"/>
        <property type="gene ID" value="VAB18032_26601"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26601"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_11"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="14">
        <location>
            <begin position="32"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="13">
        <location>
            <begin position="244"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB46397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="517" mass="54963" checksum="8ACB74F7CB2AFC56" modified="2011-06-28" version="1">MTDGRVSPDETTFTELAARWRVVPVTRRLLADAETPVGVYRKLAGGPGTFLLESAEQGVGSAGLAWARYSFVGVRSSATLVERDGAAAWLGTPPAGLPTTGDPVEVLRATVAALAGPPGDPQGGMPPLTGGMVGYLGYDLIRRFERLPALTEDDLAVPELGMMLATDLVVLDHFDGSAILVANAILPPQDEPGREALVAAAYHHAVGRLDAMTTALSRPIPPMVSTVHRPPVGEVRSRTPDGGYPKAVEAAKEAIRAGECFQIVLAQRFERDTAADPLDVYRVLRTTNPSPYMYLLRFDDFDIVGSSPEAHLKVTIEESGERRALLHPIAGTRPRGATPEADARLAAELLADPKERAEHVMLVDLGRNDLGRVCRPGTVEVPEFATIERYSHVMHIVSTVVGTLREDRTAFDALAATFPAGTLSGAPKVRAMEIIEELEPVRRGLYGGTVGYFGFGGDLDMAIAIRTALMRAGRAYVQAGAGVVADSDPAAEDQETRNKAAAVLAAIAAAETLRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHV3</accession>
    <name>F4FHV3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736278.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02810"/>
    <dbReference type="EnsemblBacteria" id="AEB47646">
        <property type="protein sequence ID" value="AEB47646"/>
        <property type="gene ID" value="VAB18032_02810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02810"/>
    <dbReference type="eggNOG" id="ENOG5032XQY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044677_0_0_11"/>
    <dbReference type="OMA" id="ARYVAWG"/>
    <dbReference type="OrthoDB" id="1868844at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="14154" checksum="42BC0D4B583973AA" modified="2011-06-28" version="1">MRLRTDDDIYRARLVYLGPPGYTLPVHLPYAQYGLFMLLVPLYMFIHWLFTLQVELFPAWEIALAIVTTSFVFRYVDPDRPARMVIRTALTDWRRTREPAAEQRDPRLVGSGIRIREELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI14</accession>
    <name>F4FI14_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ordered locus">VAB18032_03115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736339.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03115"/>
    <dbReference type="EnsemblBacteria" id="AEB47707">
        <property type="protein sequence ID" value="AEB47707"/>
        <property type="gene ID" value="VAB18032_03115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03115"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_0_11"/>
    <dbReference type="OMA" id="CPIVIFT"/>
    <dbReference type="OrthoDB" id="912786at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="26023" checksum="26EF210F0DDF9AFA" modified="2011-06-28" version="1">MSGKLLVPYVTGGIRPDWTRYVEEYARHGADMIEIGLPFSDPILDGPTIQQASHHALQQGVTVRSILDDLTGLNVDVPLIAMTYYNLVIHNPSFCADLAAAGVSGLIVPDVPIDEVDELEATATAAGVDLVLLAAPTTTPSRLAAIAQRSRRFVYAVSVMGTTGERDRLGEDALRLARELRAMTDLPVLLGFGISQPAHAVAAADAADGVVVASALMRMVLDGAGPEEIGATIAEFRAALDGVVVGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI20</accession>
    <name>F4FI20_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47984">
        <property type="protein sequence ID" value="AEB47984"/>
        <property type="gene ID" value="VAB18032_30104"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30104"/>
    <dbReference type="HOGENOM" id="CLU_2866575_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="6508" checksum="C9AB6E4CC72C44DF" modified="2011-06-28" version="1">MMDDQALRVVWLAISVLAAVIVASGAGVLARLAGAHFPKAVITAATAFGGALLLILAMIGFVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F131</accession>
    <name>F4F131_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731358.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07835"/>
    <dbReference type="EnsemblBacteria" id="AEB42685">
        <property type="protein sequence ID" value="AEB42685"/>
        <property type="gene ID" value="VAB18032_07835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07835"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052806_0_0_11"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="315" mass="34776" checksum="02112E50C2B091A6" modified="2011-06-28" version="1">MDEWLSIGDVARRTGLSVSAIRFYADEGIVAPAGYTGAGYRCYDARGVAALELVRTLRDLGAGLEEIRRLLADEITVRDLAAAHLALVERQMGQLRTRRAVLRAVVRQDSEAGQVSLVHRLASMSDDDREQLVEEFWTEVTDGLDVREFVDYLRPWRPRLPEDPTGEQLDAWIELADMVRDAGFRRAVRQYFGETFADAADHGRDDPSTEAEVAEQVEILAQARAASEAGVPVDSREARQLATRWVALAGSRCGERDLTEVRRQVVAADPEPQVARHVALLGRYHSLTATINGTPQPVVRAPASTWLHAAVAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1F5</accession>
    <name>F4F1F5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FxsA cytoplasmic membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733839.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20420"/>
    <dbReference type="EnsemblBacteria" id="AEB45184">
        <property type="protein sequence ID" value="AEB45184"/>
        <property type="gene ID" value="VAB18032_20420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20420"/>
    <dbReference type="eggNOG" id="COG3030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085083_2_1_11"/>
    <dbReference type="OMA" id="FQQVRIH"/>
    <dbReference type="OrthoDB" id="2023211at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="19002" checksum="71EF368DE41B698F" modified="2011-06-28" version="1">MRRSLRFVPLALLVSVVAELAVFVLVGRAIGFGAATLLVFAASLLGMVLLRREGIRAWRGFREAAQSGRPPGRQVTDGLVGLLGALLLATPGLVSGLVGVVLLVPPVRKVARGGMQRAAERRVSSMTAGDLFGPRRVRVYRGAPQPGEAGRPEPTGPAAPPPPVAPVVDNGQAIEGEIVEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1J9</accession>
    <name>F4F1J9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetolactate synthase catalytic subunit</fullName>
            <ecNumber evidence="5">2.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733882.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20640"/>
    <dbReference type="EnsemblBacteria" id="AEB45228">
        <property type="protein sequence ID" value="AEB45228"/>
        <property type="gene ID" value="VAB18032_20640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20640"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_4_0_11"/>
    <dbReference type="OMA" id="GAREPME"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="405"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="579" mass="61064" checksum="D36A780F2CE9CA5F" modified="2011-06-28" version="1">MTSGPAAASAAAAVLAAAAASGVQRLWFNSGSELTSFQEAHAQARHHGRPTPELITCPHEHVALTAAMGETMVTGRPAMTAAHADLGLLHHGGAIHNAMWGDHPIMIMSGYPPTRAEARTSPVFWKQQRWDQGSIVRQYVKWDYKLSALDDAGLVVARGLQVALAPRPGPVYLAMPEEVGRYPVPADGPTPSAQMLGIPRLGPGDPDVVSEVARRLTTARRPVVVTDRVGVNPQAVALLAELADTLGVQVRASRYRMNLPDDNPWHTTDALDQFDVIVVLDHPVPWMPAVERPRDDAWIGWVGPDPIESRVPLYELRADARTTADPAAFLAAVLAEVGSAGPGDADSIRRRRQHPPAAGRARRSTDGGAPASGVPTPALIAAALDRHLRPDDLLTWEVFDTTTVSRTKPGTLFEKGGSSLGWSVAAATGASIAAGGAHAVAVTGDGSYLFGSPDSCLWLQQQCDAPVVTVVVNNGGYRTGTTTLAAHYPGGLAVTEPTVLGGHLTPSPDFAAHARSQGCYGERVVAAADLAAALDRARTSVERDRVPAVLDVWVPEHLTGSMDPGRRARTPADEGNTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1M4</accession>
    <name>F4F1M4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733907.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20765"/>
    <dbReference type="EnsemblBacteria" id="AEB45253">
        <property type="protein sequence ID" value="AEB45253"/>
        <property type="gene ID" value="VAB18032_20765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20765"/>
    <dbReference type="eggNOG" id="ENOG50330PX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191540_0_0_11"/>
    <dbReference type="OMA" id="CQHQPSC"/>
    <dbReference type="OrthoDB" id="2031580at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046041">
        <property type="entry name" value="DUF5999"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19462">
        <property type="entry name" value="DUF5999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="66" mass="6931" checksum="053398D90E6121F4" modified="2011-06-28" version="1">MCQHQPTCPSADATDREAAKAIACFPEQGWSLLCNGVIVFEDTGELLPDGSSIAPHRGPARHALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Q1</accession>
    <name>F4F1Q1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase coenzyme F420-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27016"/>
    <dbReference type="EnsemblBacteria" id="AEB46476">
        <property type="protein sequence ID" value="AEB46476"/>
        <property type="gene ID" value="VAB18032_27016"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27016"/>
    <dbReference type="eggNOG" id="COG2085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_0_2_11"/>
    <dbReference type="OMA" id="RDGHIPE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="222" mass="23280" checksum="0569038224FB3BDD" modified="2011-06-28" version="1">MGLIGSGHIGGTVARLAVAAGYEVVLSNSRGPETLSDLVDELGPGASAGTVDAAARAGDLVVVSIPLKSYRAVPAQPLAGKVVIDTNNYYPQRDGQIPELDEDTVTSSELLQQHLPEARVVKVFNNIFFRHLLALARPAGAADRSALPIAGDDAEAKAVVTAFLDRIGYDAVDAGTLADSWRFQPDTPAYGTIYSADPANWEQEAPGDADKVRAALAKAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Q5</accession>
    <name>F4F1Q5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27036"/>
    <dbReference type="EnsemblBacteria" id="AEB46480">
        <property type="protein sequence ID" value="AEB46480"/>
        <property type="gene ID" value="VAB18032_27036"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27036"/>
    <dbReference type="eggNOG" id="COG4911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137908_0_0_11"/>
    <dbReference type="OMA" id="PAVSHWH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018699">
        <property type="entry name" value="DUF2203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09969">
        <property type="entry name" value="DUF2203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016498">
        <property type="entry name" value="UCP016498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="122" mass="13583" checksum="1449FABC309D1087" modified="2011-06-28" version="1">MTHTGAVFTLAQARHLVATLQPRIDELIRVRADLTELQVDLANHGLSALGGRPELKGLEARLHAICDEIGQHGIEIKSVAPVLLDFPGEREGRQVLWCWLEGDADVRWYHRADCGFAGRRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F244</accession>
    <name>F4F244_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731406.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08075"/>
    <dbReference type="EnsemblBacteria" id="AEB42733">
        <property type="protein sequence ID" value="AEB42733"/>
        <property type="gene ID" value="VAB18032_08075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08075"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_11"/>
    <dbReference type="OMA" id="SCDMVVC"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="26957" checksum="56A1B4E7EDA4A674" modified="2011-06-28" version="1">MTELLVDRTDAVVTLTLNRPSAMNSLNVALKEALRDTLAELEADRSCRAVVLAGAGGSFCAGQDLREHVATLESGAGKTLDTVQAHYNPIAARLSSLPKPVVAAVRGMAAGAGASLAFLADIRVGGPSTKFLMAFAKVGLAADTGASWTLPRLVGHAKAIELLMLAEPVGADEACQLGLLNRMVDDDEGVLPAAQELAARLAAGPTVAYGAIKRQLSVADAGTLADALAAEAQAQAICGGTNDHRAATMAFVNKQRTVFEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F251</accession>
    <name>F4F251_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_08110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731412.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08110"/>
    <dbReference type="EnsemblBacteria" id="AEB42740">
        <property type="protein sequence ID" value="AEB42740"/>
        <property type="gene ID" value="VAB18032_08110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08110"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_0_11"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="126"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="382" mass="39615" checksum="9D16676230965D89" modified="2011-06-28" version="1">MSAPVSTVNDAVQAALATVNDPEIRRPITELGMVRSAEVDQDGVVRVELLLTVAGCPLKDKLRSDITAAVSAVSGVTGVEIEFGVMSPEQRQGLQAKLRGGSAGEEPVIPFAQPGSRTRVYAVASGKGGVGKSSVTVNLAAALAARGLSVGVVDADIYGHSVPRMLGADGRPTRVEDMIMPPQSHGVKVISIGMFTSGNAAVVWRGPMLHRALQQFLADVYWGDLDVLLLDLPPGTGDVAISLAQLLPNAEILVVTTPQAAAAEVAERAGAIALQTHQRVVGVIENMSWLELPDGSRMEVFGAGGGQTVADSLTQTIGAQVPLLGQVPLDTRVREAGDEGNPIVLAAPDSPAAQALNKVADRLAVRRESLLGKPLGLKPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F291</accession>
    <name>F4F291_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731451.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08310"/>
    <dbReference type="EnsemblBacteria" id="AEB42780">
        <property type="protein sequence ID" value="AEB42780"/>
        <property type="gene ID" value="VAB18032_08310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08310"/>
    <dbReference type="eggNOG" id="COG3795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130902_1_0_11"/>
    <dbReference type="OMA" id="TWVRYDG"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="135" mass="14731" checksum="1FACD57E2C3AC479" modified="2011-06-28" version="1">MAKYLLLKHYRGAPAAVNDVPMDQWTPEEISAHMQYMSDFAARLEATGEFVDGQALAPEGTFVRYDGEGRPPVTDGPFAETKDLIAGWMIIDVDSYQRAIELAGELSAAPGAGGKPIHEWLEVRPFLAAPPTITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F349</accession>
    <name>F4F349_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="5" type="ordered locus">VAB18032_03730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736460.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03730"/>
    <dbReference type="EnsemblBacteria" id="AEB47828">
        <property type="protein sequence ID" value="AEB47828"/>
        <property type="gene ID" value="VAB18032_03730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03730"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_545028_0_0_11"/>
    <dbReference type="OMA" id="PPLHARY"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="504" mass="58212" checksum="1FBC245888799377" modified="2011-06-28" version="1">MTTSPLDRAADSFAAELARHRTERGLSKKQLATLMGFDPSYVSHVEGRRHRPTEDFARRAEAVLDASGAIWQRFREYDHLRHARTERDPREPDPSGRWIPPGTGLIVENESSILTYTEDGYRCLIRRELYNAGTEPITRYLVRVAVDRYPNDPGRSNRHHRERPLTFAELGLRAYREESGEREAMHWRAKYDRDAFKEIWLLFENGERRFPLYPGHRATIEYTYTVGRDKWGPWFQRAVRVPTRHLAVRLDLPAELDPQVWGAETSLSAEEGPLRRAVARRDEGDRAIFEWATDDPPLNARYRMQWRFRAQSDAEPEGERIRPSERMRGLGILQRGADLLRQPARPFDLPREARAAREVIDRLTDALARLDELHPFAKGVGIAAPQLEIGRAAAVIRPPDRTAEPLVLLNPRVVDAAPDTDEQYEGCLSFFDHRGLVPRPLRLDVEHAQLDGRRVITSFEFGMARLVAHEIDHLEGRLYVDRMAPGVPLVPIEEYRETGHPWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F394</accession>
    <name>F4F394_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Resolvase helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731489.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08500"/>
    <dbReference type="EnsemblBacteria" id="AEB42818">
        <property type="protein sequence ID" value="AEB42818"/>
        <property type="gene ID" value="VAB18032_08500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08500"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058432_0_0_11"/>
    <dbReference type="OMA" id="WVRDLPK"/>
    <dbReference type="OrthoDB" id="1219306at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="32134" checksum="13F4FA1BA17901C6" modified="2011-06-28" version="1">MTDPRGDEVRRLRTVEQLSVREIRARTGLGRNRVYDLLRGVPPPERTRRPNAKDSLRAEAVALRSTGHSVPEIAQRLGVSRSTAYLWVRHLPLQRDPEQEQQRRRAHSKTMTEGRWATHRRERDEAQAAVHDLAARVVGDLDDRDVLLLGAVSYWCEGTKSKPWRRDDHVQFVNSDPGLLLLFLRFLEVCGVDRAAPSYRVSIHETADAEAAADWWAEELALPRDRFQRSTLKKHKVNTARRNVGDAYRGCLVINVPGSRELYWRIEGMIAGLFQSVRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3H9</accession>
    <name>F4F3H9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shikimate-5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14875"/>
    <dbReference type="EnsemblBacteria" id="AEB44087">
        <property type="protein sequence ID" value="AEB44087"/>
        <property type="gene ID" value="VAB18032_14875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14875"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_0_0_11"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="3">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="4">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="277" mass="27364" checksum="28EE050E9434EA29" modified="2011-06-28" version="1">MAGSVHKAAVVGKPIAHSLSPVIHNAGYAAAGLDGWSYTRIECAAAELADLVAGLGPEWAGLSVTMPGKEAALAVAAEVSPVAAAVGAANTLVRRPDGSWYADNTDVTGMVEVLTEAGVGAGATVTVLGAGGTARAALAAAARLQAAGVTVIARRAAAVAELTPVAHTLGLALTAAPWSEAVASTNADVLISTVPKGAADGLADAVAWRPTTVLFDAIYDPWPTPLAASAAAAGCRVVSGLDLLLAQAIGQFEQFTGVPAPRAAMSSALTAAYANRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3K1</accession>
    <name>F4F3K1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ordered locus">VAB18032_14985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732776.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14985"/>
    <dbReference type="EnsemblBacteria" id="AEB44109">
        <property type="protein sequence ID" value="AEB44109"/>
        <property type="gene ID" value="VAB18032_14985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14985"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_2_0_11"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="153"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="32902" checksum="8803A4F4A56A3FEF" modified="2011-06-28" version="1">MIRHLLSGADLDADTAIQILDTAAEMAAVSGREVKKLPALRGRTVVNLFYEDSTRTRISFEAAAKRLSADVINFSAKGSSVAKGESLKDTALTLQAMGADAVVVRHPASGAPHRLADWVDGSVVNAGDGTHEHPTQALLDAYTMRSRMGRLAGLSVAVVGDVLHSRVARSNVLLLSTLGAKVTLVGPPTLIPVDIAAALAPGTAVCYDLDAVLPSTDVVMMLRVQRERMGDSYFPSAREYARRYGLDGARMRRLPEHAIVMHPGPMNRGMEITPEVADSPRSTIVEQVTNGVSVRMAVLYLLLGGNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3V8</accession>
    <name>F4F3V8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21545"/>
    <dbReference type="EnsemblBacteria" id="AEB45409">
        <property type="protein sequence ID" value="AEB45409"/>
        <property type="gene ID" value="VAB18032_21545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21545"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002470_0_1_11"/>
    <dbReference type="OMA" id="EWTRDYV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313571" evidence="1">
        <location>
            <begin position="19"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="500"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="695" mass="75444" checksum="5C1F3EA230824F6C" modified="2011-06-28" version="1">MAGLTAIALTATPTPTMAAPAPTSAPPDSAFQKVTLNDRPGEPMDLAVLPDRRVLHVTRAGQVWLHNPATGRNTIAATLDVYQHDEEGLQNVAIDPGFGKGGNNWVYLYYSPPMDTPVDDPSTPDVNEGDAPAWGTEEDFAPFRGVIRLSRFRLVKDKLDLKSEQQIIDVPVDRGICCHVGGDIVFDSKGNLYLSTGDDTNPFESGGYAPIDERPGRHPAYDAQRSSANTNDLRGKILRIKVGAKGGYTVPKGNLFKKGTPNTRPEIYLMGLRNPFRIELDRTSDTLFVGDYSPDARQPNPDRGPAGQGKWLAAREPGNHGWPYCITPDQPYLDYDFATDQPGAPFNCAAPVNDSPHNTGLRNLPPVQQPQVWYGFGLSPQFPELGTGGIGPMAGPAYRFDRSTTRGRNPSGWPAYYDGKPLFYEWTRDYVKAFELDRRGELRGIESVLPSVVFDNPMDLEFGPDGALYVLEYGDGYFSENPDAQLARVDHIGWDGNHSPVPQVSATQTAGLAPLTVEFSSAGTADPDGDRLRYEWYLDDDDKVDSREANPTFTYRRNGSYEATLKVTDQKGRSASASVRVVVGNATPVVELVSPVVGQPFTFGDVVQFEVRVTDDQPVDCARVSVTYILGHDDHGHPITTANGCTGTITTTVPSGHDPATDNLSAVFVASYTDPGGDGLPPLTGTTEVVLVPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3W6</accession>
    <name>F4F3W6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21585"/>
    <dbReference type="EnsemblBacteria" id="AEB45417">
        <property type="protein sequence ID" value="AEB45417"/>
        <property type="gene ID" value="VAB18032_21585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21585"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_13_2_11"/>
    <dbReference type="OMA" id="RGTQIAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="429" mass="45058" checksum="2EFC2DCAD54A1B50" modified="2011-06-28" version="1">MPRSPRFGLLREPDFRRFFGATVAGQLSDRFVFLALPLVAIVWLDADEFEVGVLTAMTTAGSLLIGLPAGAWIDRWRKRPVMVNTDLVRAALLLLVPLAWWTDTLTIWLLFAVALAHGLLTVLFEVGYTSYLPALVGREHLVEGNAKVAAARSAVSISGPGLAGPLVAWLGAPLTLVASSAGMLLSALGVLRIRTPEPQPPAAAGRHLAREVAEGLRFVLGHPLLRPTLFTDGIFSLFLVTYQTMLLVFLSRHLGLGSFGIGLVLSAMACGGFAGALLARRVVARIGPGPAVWLAPLCTAPAAGLMPAARPGWLLWLAVAGLALLSLGGVIRLIAQVGLQQHVTPDRLLGRMSATVRFVQWGSMPIAGLLGGLLGSLLGAPAVLWIGAAGMTAAFLPALLSPLRATRELPVMDEGLTPASPTAGSGHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F432</accession>
    <name>F4F432_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735328.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28026"/>
    <dbReference type="EnsemblBacteria" id="AEB46678">
        <property type="protein sequence ID" value="AEB46678"/>
        <property type="gene ID" value="VAB18032_28026"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28026"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_0_11"/>
    <dbReference type="OMA" id="FFYGRWD"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="279" mass="30403" checksum="EBF358572ED16E11" modified="2011-06-28" version="1">MVFFDGTDGTRLAYHQVGEGSPLICLPGGPMQSSAYLGDLGGLSAHRRVVRLDLRGTGDSAIPADPATYRVDRLVEDVEALRAHLGQERIDLLGHSAGGGLAVRYAARHPDRIGRLVLVTPSPRVVDLEVTDADRRQVAELRHSEPWFPAAFAAFERIWSGDATAADWQAIEPFMHGRWDADLRTRLDREASQRNAEAAGIYYSAGALDPQATRADLAHLRAPVLLVAGEYDVALPPSCAAAYATLFPQAELAVLPTGGHQPWHDDPQWFLQTLTAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F446</accession>
    <name>F4F446_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28106"/>
    <dbReference type="EnsemblBacteria" id="AEB46692">
        <property type="protein sequence ID" value="AEB46692"/>
        <property type="gene ID" value="VAB18032_28106"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28106"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_17_0_11"/>
    <dbReference type="OMA" id="CTPGDTH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="149"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="43172" checksum="4F70C9AE5F6DB2C8" modified="2011-06-28" version="1">MSTNDNELRVGMVGYAFMGAAHSQAWRTVNRVFDLPARARMALICGRDSGKVAEAADRLGWDEHTTDWRELVSRPDIDVVDICTPGDSHAEIALAALAAGKHVLCEKPLANTVAEAQEMAAAAASARAGGARSMCGFNYRRVPAVALMRQLVAEGRLGEIRHVRATYLQDWIVDPQFPLVWRLRKEVSGSGALGDIGAHIIDLTQYVTGQQITGVSAVTETFVKERPLPSESSGLAAQTDGGSAATGPVTVDDAAIFVARLNGGALATYEATRFATGRKNALRVEINGSLGTVAFDLERLNELEYYDATRPAAEQGFSRILVTESDHPYLSAWWPPGHIIGYEHSFTHQMRDFIEAVATGVDPSPSFAEALQVQLVLDAVVRSAELGSLWTAVEPALATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F450</accession>
    <name>F4F450_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47863">
        <property type="protein sequence ID" value="AEB47863"/>
        <property type="gene ID" value="VAB18032_03905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03905"/>
    <dbReference type="eggNOG" id="ENOG502ZG5Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064270_0_0_11"/>
    <dbReference type="OMA" id="LEPMRED"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="25314" checksum="AF1B88A77D3D916A" modified="2011-06-28" version="1">MFGFARRKTQGQLARAELNRGVGHLRQAATHAAKGAGATVGPRVEAARSAVMPATVMIRDRASSGLATTAAALAPLTLAMRQAQAEAAGKAAAGKKVAATKKAAATRKVKAKNMKAKKKSRRGTMIGLLAAGTVAGLAGAMALRRYREQQAWAEYDPGTTLEPMREEVETIEVRTTGPAGAGKASTGAGSSAVAAGDSASTTKTTTPPKPTPTDKVPSVAEGARTTSGRPADNLTKAVNNSPTSSNGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F463</accession>
    <name>F4F463_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase internal region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736508.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03970"/>
    <dbReference type="EnsemblBacteria" id="AEB47876">
        <property type="protein sequence ID" value="AEB47876"/>
        <property type="gene ID" value="VAB18032_03970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03970"/>
    <dbReference type="eggNOG" id="COG3275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_3_0_11"/>
    <dbReference type="OMA" id="FRRHGDF"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="283"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="408" mass="42896" checksum="08A722C9A7EC4FB9" modified="2011-06-28" version="1">MGGNLSAGIGVLSLVVVLTGALVAVARLRGRRGIATASQRATYEVLHTTGLAAEPLRAGLSPAGAAKAARHLRGLVGAAGLALTDTEEVLALDGRGAHHTDQLRAAAQRVVATERSTVLGEAELFCDRIDCAVRGAVVAPMAGAEGRVAGAMIAVTDGVPGPGLVQATMETARWAGSQLALAELDSSRERLARAEVRALRAQISPHFIYNALTAIGSFVRTDPERARELILEFAEFTRYSFRAHGEFTTLAEELRSIDRYLTIERARFGDRLQVRLQIAPEVLPVTLPFLCLQPLVENAVRHGLSRKPGTGMVSIEARDAGAECHITVEDDGVGMDPGTLTAGIAELAGATGDPGDDPGQHVGLSNVDERLRSVFGSDFGLVVETGVGSGTKVSMRVPKFHPGVRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4C2</accession>
    <name>F4F4C2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, sarp family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04265"/>
    <dbReference type="EnsemblBacteria" id="AEB47935">
        <property type="protein sequence ID" value="AEB47935"/>
        <property type="gene ID" value="VAB18032_04265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04265"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_2_0_11"/>
    <dbReference type="OMA" id="HERRVTH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTAD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="938" mass="102555" checksum="71473FE638AA6DE3" modified="2011-06-28" version="1">MPERELLTRVQDGYRLDVERSDVDLFAFQAEVAEARRLVPSDEVAAVELLSGALARWQGQALTGIALGSSLSAQVVAAAEDRMLAAELYARLQIRLGNYDEALPVLRKLLITQPLREPAHLLLMQALHLRGDHAGAVAAYATARRALREQLNIEPGGELQQFYQRIAAHERRVTHREREAGPTATVVPARTGQVIRSFPPLPRALPDFIGRADAVERLLAETRRASGVAPAVHFIDGMAGSGKTSLAMHVAAQLTDRFPDAQLFIDLKGHNQAESVAPAAALAALLRQLGVAGSRIPGDFDERVSLWRHELASRRGIVVLDNAAGAEQVLPLLPSGPGNVVIVTSRRRITGLDGAPPVSLSVMTLDEGVALLASAAGAQRVAAEPDAAATVVKQCGHLPLAIRLAGSRLAHRPTWRVADLAALLVGNAHRLVHLASGDRSVAKAFAASYESLGDSARRLFRLLSVHPGDYFDVLICAAVTGFSMDDTTAALNELLDCHLVDEVKAGRYRMHDLIRQYAHELSVTQDRGVTRDRALVDLVDIMLHLSFPIAEELESRGVRKYVSLDPPRLPDLLAVTASRTKEWMEDERSTLVALVVRAGERGHHDHSWRLARVLWRFLYVRGYYDDIVRTHLAGLEAARAAKNEPAAAIMHNYVASAYLRKGNYAEALNHVRAAVTSAERRGDVINGDRYRANLVAVHWIRGELDEAVRVGLEGLRWRKGFDLGELPSSLPNVGLALALLGRYDEALRLHRLHLYLARQHGNQFHLLNALSHIGAVKCRVGQHKAAIRVLRAALALRERTGHRFAEAEVRNDLGIALRGLGRVAEAAVQHEAARQLAFEAGEPHAQAAALNDLALTMAILGDGSRASDLHHEALRLATRIAHPYEQGRALAGLAEHLLATDPAEARRHWERALAIFRRMGVPEQSEVERRLAQTDQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4I4</accession>
    <name>F4F4I4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_09120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731613.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09120"/>
    <dbReference type="EnsemblBacteria" id="AEB42942">
        <property type="protein sequence ID" value="AEB42942"/>
        <property type="gene ID" value="VAB18032_09120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09120"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_1_0_11"/>
    <dbReference type="OMA" id="VGQQQFG"/>
    <dbReference type="OrthoDB" id="1783638at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="369"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="582" mass="63339" checksum="07F2345988C88C5D" modified="2011-06-28" version="1">MTALPETAPPRMAALRRRLAGGTNSQWFPYLLVLPLVLVLYGYVVHPMFATFSESVSENGTRNYLQFFTSSGVARESLFTSLFISAASVLLCGIVGVTMAFLLKRFSFRGRRLIEAIILVPAALPPLIGAVSFQLLYSNIGIVPRGLQALFGTERPIMAFDGIAGVLVVHTFTMYPFFYLAAAAALAGMDPSVEEAAYNLGAGRVRVWRTVLLPMLTPAMVSASLLVFMTSLASYTAPLLFNVSQTMTMQIYINRTNGDLPMASAYASVLGIVSIIFLLAMRWYEGRRSYQSQSKGISANRRELTNPIGRWLAPVASVLATMVLLAPVATIALVAFSENRTWTTQVLPETYTLDNFVTIFSDPKAFEPILNSLQMSLLAAVGCVVIGVLVAYAVRRLKFIGRGLLDVAVMIAWALPGTVVAINLISAFSTGNAFSFGQVLIGTFWILPLAYFVRFLPIVFRSSSAALALIDPSLEEAARNLGASWLRAFYTITVRLMLPGVLAGALLAFVHGVGEFVASVLIYTSSTVPISVAINNRMYSFELGTAAAYGMLQVALIFVVMWFSGRLESSRTATRRAEQWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4J1</accession>
    <name>F4F4J1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731620.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09155"/>
    <dbReference type="EnsemblBacteria" id="AEB42949">
        <property type="protein sequence ID" value="AEB42949"/>
        <property type="gene ID" value="VAB18032_09155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09155"/>
    <dbReference type="eggNOG" id="ENOG502ZEFP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094927_0_0_11"/>
    <dbReference type="OMA" id="LMAVYHA"/>
    <dbReference type="OrthoDB" id="1782620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313588" evidence="2">
        <location>
            <begin position="30"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="26793" checksum="40451E25B8B7871D" modified="2011-06-28" version="1">MRARRLVAVASVAVGLVALSGCRSEPGVAAYIGDHSVTEDAVTALIDDARAKNPAPTEEDAAMPGQQPRLPGRSEVVSVLVLSEVCERVSAAENYRPQNVVDPAQIAQGVGMNPETEYVRRTAELYSCLSGIPVGEPVAPTQQELTELVNAGKRAGAVPAEVTVEEAASQLDGEQLRYALANRNSLAEAVEAYDVTVNPRYRPLVFPVLSFSGATPIVAVGVPLGEPASTAVTDVSTPKPQPADQADEGDHAGHGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Q4</accession>
    <name>F4F4Q4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732861.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15420"/>
    <dbReference type="EnsemblBacteria" id="AEB44196">
        <property type="protein sequence ID" value="AEB44196"/>
        <property type="gene ID" value="VAB18032_15420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15420"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_0_11"/>
    <dbReference type="OMA" id="DYQVHPG"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="201" mass="21893" checksum="135A9E8970E436C9" modified="2011-06-28" version="1">MSAVEHRYEVRSRQVRYSGRIFEVVSEEVTMPGGGTATRDLVRHVGAVAVVALDDAGQVVLIRQYRQPVRRRLWELPAGLTDVAGEDPAVTAARELAEEVDLTAGRLDVLVDLHSSPGFTDELVRVFLARDLADVPEQQRHDRHDEEADLQIVRIDLDEAVGMVLAGEITNASCVAGLLAAARARDAGWSALRRADAPLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4S0</accession>
    <name>F4F4S0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732877.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15500"/>
    <dbReference type="EnsemblBacteria" id="AEB44212">
        <property type="protein sequence ID" value="AEB44212"/>
        <property type="gene ID" value="VAB18032_15500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15500"/>
    <dbReference type="eggNOG" id="ENOG5032ABJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980670_0_0_11"/>
    <dbReference type="OMA" id="WCESTRR"/>
    <dbReference type="OrthoDB" id="1951458at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="13512" checksum="22920807583D4437" modified="2011-06-28" version="1">MAGTNDQRGIFTGADALTDNVALSQWFNETRRVLHAAALELGVTASELDARLRAISGGVIVGGLTARARARQVAKPITHASDALVVASQYIVTASTRFEAVYMPELEAVGHRPRKTDFRFTDGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4T6</accession>
    <name>F4F4T6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734078.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21625"/>
    <dbReference type="EnsemblBacteria" id="AEB45425">
        <property type="protein sequence ID" value="AEB45425"/>
        <property type="gene ID" value="VAB18032_21625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21625"/>
    <dbReference type="eggNOG" id="ENOG502Z7ZT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020863_0_0_11"/>
    <dbReference type="OMA" id="YERYYGI"/>
    <dbReference type="OrthoDB" id="530767at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="758" mass="83382" checksum="BA532FB8D5E92E53" modified="2011-06-28" version="1">MSDNDIRVGVGFPLGQLARALTTAGTHEDPATRQRAERRVRRWQQVVDGMAAGTLDIGSRTPVRDLPVWVTPEVIHGGFATGTPAAGGALRPDETDRARRLGLPAERRVLFWSWLTDAGLVELGELLDSGRYRVEYAEEAALPVVAWLLRAGERDAAVNLLEEIAPYADRLRFTPGPNDQPAVDPDVVYRQTAGEVRRLLEQRQPNAQIETMREALTVWNPFADELLTRWCETVVDGRVDAVTPDDWLPRAAQLLARYRHLAAAHPRCGRHRHRKGSIGVLRTALERRVAGAQLTPRERGLVQSVVEAMLRKRGRPGSPEHTALREQQAREAALPRHHQLAQLVAARLAALPQDVGIHDVDHVLRPVDADESHLAGVVAGWPAPAPVARVVARATAATLEQLIARGVIASAEELARLTPRLAAATAASAYPDPALRILMDATYRAFRARRSLLLLNLEHQVRLAELPWVRAVVSARIDTSDTRDQARRTLARLGSAAVTGFPATVLPNPLVKELSTLSTQASLPLPWVEELAADIFMGTFSAKFLQAATLAGRRLAGSLYARYYDIDYPAIAAIDDTRRRLIRRARTSNTFDELCRDRAGASRRRSWFQVAANGTIIEQAQILTTHNLATIVELGIDLPAIDLAKQCLDTVLRLTARLHHNPRPLGTVKNTAYAWRQMVFFLSLSTGEEQTAFLSHAAQRLAAQPDHVRTRLAPAVIGLGHIVGGGTFDQDGRAGTGRRLLGWTTRAHWMLDPSLEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4U8</accession>
    <name>F4F4U8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-70 family RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_21685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734090.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21685"/>
    <dbReference type="EnsemblBacteria" id="AEB45437">
        <property type="protein sequence ID" value="AEB45437"/>
        <property type="gene ID" value="VAB18032_21685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21685"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_11"/>
    <dbReference type="OMA" id="YLAVWRA"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="19813" checksum="9731A477B89D0E21" modified="2011-06-28" version="1">MDAADEGELVRRVARGDRQAFDELYRRTAPWLEVRLRRRCADPDLVAEVLQDTYLAVWRAAGSFAGAQPRGSAVGWLWTIAAHRLVDAFRRRARKARVPQVQLTPSTAPAAEDEVMAARVGQELEQALLVLPPEVRAALRATVLDGLSAREASVLLGVPENTVKSRVRRARIALREALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4V2</accession>
    <name>F4F4V2_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734094.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21705"/>
    <dbReference type="EnsemblBacteria" id="AEB45441">
        <property type="protein sequence ID" value="AEB45441"/>
        <property type="gene ID" value="VAB18032_21705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21705"/>
    <dbReference type="eggNOG" id="ENOG5033Y26">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116759_0_0_11"/>
    <dbReference type="OMA" id="WLPAFAY"/>
    <dbReference type="OrthoDB" id="2067520at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="199" mass="21005" checksum="77BF8E901220FEA1" modified="2011-06-28" version="1">MTFAILYLRSRRVPLALAVALGGAAVIWTLWLAFAAKPDIPTYVVAMTILLMAAVLSATLAGPDENLDRTASLRWPWRRALHLLAGLGVIVIVQIATLHTGARFGPAALVLRDAAGLMGLTALCTAVVGADRSWFLPLGWTTISVMYSQEGTWAAAATWQGQLPGNRPAALTATALAVGGLIAYSLAGPARREAAEYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Z4</accession>
    <name>F4F4Z4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_21915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21915"/>
    <dbReference type="EnsemblBacteria" id="AEB45483">
        <property type="protein sequence ID" value="AEB45483"/>
        <property type="gene ID" value="VAB18032_21915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21915"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_7_11"/>
    <dbReference type="OMA" id="GMNNTGQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312690" evidence="7">
        <location>
            <begin position="30"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="9">
        <location>
            <begin position="510"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="9">
        <location>
            <begin position="632"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="8">
        <location>
            <begin position="794"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="744"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="895" mass="91514" checksum="C0D64AB36D527B1B" modified="2011-06-28" version="1">MTPAGQRRRSLLRSGIVAAAIVLALTAAAAPAVTTPAEGQILAAGGPSAVTGSYIVVLRDAAVGTKSVDTTARTLAERQGGNVGQVYRHALRGFEARLTERGARRLAANPAVASVTQNHTVSVSDVQSPTPSWGLDRIDQRALPLDNSFTYPRVTPAVRAYVIDSGINVAHTDFGGRAVSGWDFMEGDADANDCHGHGTHVAGTLGGTTYGVAKDVQLVGVRVFNCNGRGTTAQVIAGVDWVTGDHDPGELAVANMSLGGPAYQPMVDAVQRSIADGVTYVVSAGNEDGADACTTTPASVPEAITVAATGPNDARAAFSNIGTCVDLFAPGVDITSAYIDGNTSTRTASGTSMAAPHVAGAAALVLANNPTYTPAQVTQALLDNATPGVVTDPGIGSPNRLLHVNSTVPANDFTLTATPASGTVTPGGTVSTTITGTVTRGVAQPVSLAVSGLPEGVTATFQPASISSNASTTLTISTAATMLAGSYTISVIGTGTDAIRPVAYQLGIDNPPGCVASDGTDRVISEGQNLYAPITITDCAGRAARNSTIELHIGHANISELDVRLISPAGTWYYLLDHTGAGAKRVDYTLTYDLSSETANGTWQLYVSDNMYQGTGFLDSWTLNLAGVDLPPPACGGIATADVRIPENGTIESPINVADCGRAPSTTSYVETNIAHQYNRDLRLSLVAPDGQAFLLKESLVGSYRANSREAFILDLSSKPTPGTWKLRVENVASYAGMLDGWKLTLDGGPPATTPPPTTPPPTTPPPTTPPPTTPPPTTPPPTTPPPTTPPPTTPPPGASCTAVYTVQDQWNGGFVATVTVTAGTTALNGWRVTLTLPSGASVVNVWNGVRSGTSGTVTVMNEQYNGGLTAGQTTSFGFQGAGNGNGTTATCTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4F508</accession>
    <name>F4F508_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ordered locus">VAB18032_21985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734150.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21985"/>
    <dbReference type="EnsemblBacteria" id="AEB45497">
        <property type="protein sequence ID" value="AEB45497"/>
        <property type="gene ID" value="VAB18032_21985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21985"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_11"/>
    <dbReference type="OMA" id="YTRRAEI"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="125"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="30230" checksum="5427A6323E19EE0E" modified="2011-06-28" version="1">MPKTARLLPGVPVAEAVFADITRRVAALRERGVTPSLATILVGDDDASAGYIRIKQRQARQLGFDSPHRHLPAYTTQHDLLDVIAGLNADPDVHGVLLQYPIPDHLDYDAALLALHPDKDVDGLHPLNMGRLALGLPGPLPCTPAGIEALLTHHQISVAGREVVILGRGATIGRPLAILLAQKRPTANAAVTVVHTGVPDWSRHTRRADILVAAAGVPDIIQPEHVRPGAVVIGAGVRYAGRRLLPDVDEACATVASAITPRVGGVGPTTVAMLFRNAVTAAEHATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F4F517</accession>
    <name>F4F517_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="17" type="ordered locus">VAB18032_28141</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735349.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28141"/>
    <dbReference type="EnsemblBacteria" id="AEB46699">
        <property type="protein sequence ID" value="AEB46699"/>
        <property type="gene ID" value="VAB18032_28141"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28141"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_1_11"/>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00766">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="266"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB46699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="620" mass="67843" checksum="B676D197BA1808EA" modified="2011-06-28" version="1">MAGRIRDEDIALVRERASIAEVISDTVTLKSAGAGNLKGLCPFHDEKSPSFNVSPARNVWYCFGCGAGGDAIKFLMDAEHLSFVEAVERLAARVGLQLRYVEDDRSTPRRERPQQGQRQRLVAAHAAAAEFYTAQLTTAGARAAREFLAQRGFDRAAAERYGCGFAPEGWDPLTRHLRQRGFSHDELVTAGLSRPARSGSLIDRFRRRLLWPIRDLTGDVIGFGARKLFDDDDGPKYLNTPETPIYKKSQVLYGIDQAKREIAKQGRVVVVEGYTDVMACHLAGVPTAVATCGTAFGGDHIGVLRRLLLDTDAVAGEIIFTFDGDAAGQKAALRAFEDDQRFVGRTFIAVSPDNMDPCELRLAKGDLAVRDLVARREPLVDFALRHVISRFDLDTVDGRVEAMRRAAPLVAKLKDQEKRPEYVRKLAGDLGMEIEPVQRAVLAAASGRPMDTPARPARSEPSVDSPQSMVEREALKLALQEPVLAGPMFDAVEATDYRHPVHVVVRTAIAEAGGAASATAGAVWVEAVRDACEDLAAQALVGELAVEPLRIDGEPDPRYVSITMARLQWGSVTARIRDLKSRIQRINPVSNKDEYFATFGELLSLEQHARALREQAAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F579</accession>
    <name>F4F579_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28451"/>
    <dbReference type="EnsemblBacteria" id="AEB46761">
        <property type="protein sequence ID" value="AEB46761"/>
        <property type="gene ID" value="VAB18032_28451"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28451"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_11"/>
    <dbReference type="OMA" id="MALGFCA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="29731" checksum="1E1EED29202AD038" modified="2011-06-28" version="1">MIRYGAGMPVAVVTDSTTYLPPELVLAHRLTVVPLTVVLNGVEGLEGVQVFPADATRALSARRISVSTSRPSPEQFTRTYRSLLEAGAEGIVSVHLSAALSGTVEAAELAAAQFGGQVTVVDSRSCGMGLGFANLAAARAAAQGADLAGVRAAAVDAAGRTATFFYVDTLELLRRGGRINAAEALLGTALSVKPILHMPDGGIVLKDKVRTASRGVARLVDLAVEAAGDAQVDLAVHHLAAPQRAEDLLGALTARLGDRLHDTYVTEAGAAVAAHVGPGLACVVIHRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5E8</accession>
    <name>F4F5E8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydrolase, peptidase m42 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_09310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731651.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09310"/>
    <dbReference type="EnsemblBacteria" id="AEB42980">
        <property type="protein sequence ID" value="AEB42980"/>
        <property type="gene ID" value="VAB18032_09310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09310"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053520_0_0_11"/>
    <dbReference type="OMA" id="HGMERTH"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017537">
        <property type="entry name" value="Peptidase_M42_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03106">
        <property type="entry name" value="trio_M42_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="397" mass="42419" checksum="E4EBC2C1D8FCBA96" modified="2011-06-28" version="1">MTVRKTIPLPLDLEYLRQVLIELLDIPSPSGRTDHVQQYVGERLSALGIPSTLTRRGALSACLPGPREHGADRAIVVHTDTIGGMVKRLKENGRLELKPIGTHSARFAEGAHVRIFTDDLERVITGQVLPLKASGHRYNEAVDLQGIGWEQVEVRVDEPVEDIDGLRALGIDAGDFVAFLPNPTVTPSGYVKSRHLDDKAGVAAVLTAIKAMVDAGVQPAVTAHLLITVTEEIGHGASHGLDPDVAEIVSVDAAVVAPGQQSREDAATLAMGDGVGPFDYHLTRNLAAIAREHGVDLVRDVFDYYRSDVAAAVEAGAHARVALLGFGVDATHGHERTHLEGLRQLAQLLCLYLQSDLVFPEWDAEPEGDLANFPSLSVQPASEDGPREGPIGIAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5T8</accession>
    <name>F4F5T8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732965.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15955"/>
    <dbReference type="EnsemblBacteria" id="AEB44301">
        <property type="protein sequence ID" value="AEB44301"/>
        <property type="gene ID" value="VAB18032_15955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15955"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067324_1_0_11"/>
    <dbReference type="OMA" id="HAREWGP"/>
    <dbReference type="OrthoDB" id="1542930at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="27895" checksum="8CBA3DE245109FBE" modified="2011-06-28" version="1">MATTTRNRAAETALTTAETAFTLLTCEPAPLVFDARPIPGLPDTTLPLDQLRTLVKLQRYDSSTTDELWRQLAHHAREWGPAWVVGAIGVALPALTHLAAKISRGHPRHADDVDSEVLAGFLHALRTADLDTPRLWLRLCWAAWRAGSSVITADDSQELPLDLTTESRSPKMPYGHPDLLLGRAAATGLISADAAELISATRFGDALIEHLAATQGLTPSALRMRRRRAERIVAAAIVRGDLSSRTPSCGEGEYAIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5X9</accession>
    <name>F4F5X9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Argininosuccinate lyase</fullName>
            <ecNumber evidence="3">4.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_22190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22190"/>
    <dbReference type="EnsemblBacteria" id="AEB45538">
        <property type="protein sequence ID" value="AEB45538"/>
        <property type="gene ID" value="VAB18032_22190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22190"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_3_4_11"/>
    <dbReference type="OMA" id="GYYLANV"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="5">
        <location>
            <begin position="52"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="511" mass="54926" checksum="86301B31F731390C" modified="2011-06-28" version="1">MNGQPVVEPTAMPLTGRLGRAPSAVLHEHVLAPQFQFEADHLLGWYRVVERVLLAEYARMGLVTEPEAAAIAALLDTATADRITADPAANLSDICLALERHVLAGLATVPSAWHVDRSRNDIQATAQLLYARSELLDIAEALVEVTRVARRRAAAVTHLPMPGYTHLQAAQVSTPGFFLSALVEHCLRTLRRLLATYDEINLSPLGAGALTGQELPWDRDRMALLLGCAGPYPHALTAVASRAWALEIAGELSHFGVGTSRFVTDLMAWASSAYGFVELPDELAGISAAMPQKKNYPVLERIRGRTAHLTSLALDLATAQRATPYSNMVEVSKEGGAHLHDLFRSARGVLALLRTVLENLDWRPEAMRAACDREFLGGFTLANRLTLDEKVPWRTAQVIVGRYVRAKLAAGDPLDRPDASLLAGLAEAAGYRLTDPAARLRGLDSGGQLAVKCSAGSARPDHVRDLLDRQGVALDALAGQLGRRRATVEAALREVHGLFAVGSPTGARGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F606</accession>
    <name>F4F606_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22325"/>
    <dbReference type="EnsemblBacteria" id="AEB45565">
        <property type="protein sequence ID" value="AEB45565"/>
        <property type="gene ID" value="VAB18032_22325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22325"/>
    <dbReference type="eggNOG" id="ENOG50337Z7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094601_0_0_11"/>
    <dbReference type="OMA" id="FRINTMF"/>
    <dbReference type="OrthoDB" id="2054078at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="28649" checksum="0FCE162103077D11" modified="2011-06-28" version="1">MPSAVDLNTLSDMRVFDMIVDERHRAADLLDGLTAEQLSQPSLCAGWTVHDVAAHLTTYLRFGQLKIYAAIVTTGADFDRFNLRLTRRAARLPVEEIVATLRRHAASRTTIPRSGYDPVLTDVLLHDLDMRVPLNIARDIPEERLRVAFRHLTDRPSPGYTMGDRLHGLRLEATDTGWTHGSGPVVRGRAEALLLGIGGRPWAFDHLEGDGLALLRTRVRDRTRPGTIRRLMAPLRVLASPPPRDRRSRDAGVPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F657</accession>
    <name>F4F657_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_28691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735458.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28691"/>
    <dbReference type="EnsemblBacteria" id="AEB46809">
        <property type="protein sequence ID" value="AEB46809"/>
        <property type="gene ID" value="VAB18032_28691"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28691"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_0_11"/>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="155" mass="16537" checksum="FE6183F6F5AB55DE" modified="2011-06-28" version="1">MRVYLGSDHAGFELKVHLANHLAKQGYEVVDVGPHVFDPDDDYPAFCLHAGTRVVADPGSLGVVIGGSGNGEQIAANKVAGVRAALAWSVETAQLGRQHNDANVVAVGARQHTLDEATAIVEAFLTTAFSGSERHARRITQVADYEQTRKLPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F664</accession>
    <name>F4F664_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735465.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28726"/>
    <dbReference type="EnsemblBacteria" id="AEB46816">
        <property type="protein sequence ID" value="AEB46816"/>
        <property type="gene ID" value="VAB18032_28726"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28726"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_1_2_11"/>
    <dbReference type="OMA" id="VARIFND"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="10"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="36610" checksum="95AF9CF5C22399E8" modified="2011-06-28" version="1">MAQPLTHPVVDVHSHVVPKGWPDLAVACGGSGWPWLRIDSERAAMIMVGETEFRPIGAQCWDAPTRLADMTEDGVDVQVVSPTPVFFSYERPADQAVKVARIFNDLTLEVTAAGGDRLLPFCQVPLQDPDAACAEVDRCLAAGHVGVEIGNHVGDRDLDDAGIVTFLTHCAQVGAPVFVHPWDMPGGPRLDRWMARWLTGMPAETHLSVLSMILGGVFDKVPPSLRICFAHGGGSFPFWLGRADNAWHRRGDLVRGASAAPPSSYVDRFFVDSVVFAPPALRLLVDTMGVDQVLLGSDYPYPLGERPVGQVIHDADFLTEDQRALLLGGNARRFLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F688</accession>
    <name>F4F688_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735489.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28846"/>
    <dbReference type="EnsemblBacteria" id="AEB46840">
        <property type="protein sequence ID" value="AEB46840"/>
        <property type="gene ID" value="VAB18032_28846"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28846"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093167_0_0_11"/>
    <dbReference type="OMA" id="HVNNLNC"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309114" evidence="1">
        <location>
            <begin position="31"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="20710" checksum="4D2025A3243878D7" modified="2011-06-28" version="1">MNSIFRKSMLGVAGLAFAGGVFAGPVAAHADAAPVRTTPVVVQAEKPDAGKLIPHGVQGAQSRIDLNGEQVANTKAIIAATKKAGMDERAAVVSIATALQESKLENLGHLGDRNDHDSQGLFQQRPSSGWGTVEQITDPEYSTTAFLKGLKQVDGWQDMPLTRAAQTVQVSAYPDHYAQWEQQAADLVAKYWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6E7</accession>
    <name>F4F6E7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_09875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731764.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09875"/>
    <dbReference type="EnsemblBacteria" id="AEB43093">
        <property type="protein sequence ID" value="AEB43093"/>
        <property type="gene ID" value="VAB18032_09875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09875"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194488_0_0_11"/>
    <dbReference type="OMA" id="HSGKCAQ"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="141"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="232" mass="23382" checksum="E976B921B2E232C6" modified="2011-06-28" version="1">MSETDGPGTVYGTRRGGLLRDPLLGTALAIGLIGILAGVVFATGALDDGDPPSAANMAVSSAPSTEPSPTEEQPPPTTQAPEPTPSATPSAAPDPLVGPKVFAGVGSGRCLGLDGAGERAIAELAVCTGGPEQRWIVSRYGPDTVTLANAAYHQCLDVEGGSGDDGARLLQYGCHGEVNQQWRLQPVDGGAVLLVAVHSGKCAQVHGGGTAAGDDVTQAPCNGNPAQRWTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6W4</accession>
    <name>F4F6W4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dsh domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_22695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734291.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22695"/>
    <dbReference type="EnsemblBacteria" id="AEB45639">
        <property type="protein sequence ID" value="AEB45639"/>
        <property type="gene ID" value="VAB18032_22695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22695"/>
    <dbReference type="eggNOG" id="COG4581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_4_1_11"/>
    <dbReference type="OMA" id="ECHYMND"/>
    <dbReference type="OrthoDB" id="66530at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="rRNA_proc-arch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="rRNA_proc-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="43"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="317"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="925" mass="101432" checksum="5E750871278C481A" modified="2011-06-28" version="1">MSSPAERYAAARRRAAQASQFPALEEFTSDIGFDLDDFQREACQALERGSGVLVCAPTGAGKTVVGEFAVHLALRGTPGQPVPTDGARRKCFYTTPIKALSNQKYHDLVDRYGAAQVGLLTGDNAINGDAPVVVMTTEVLRNMLYAGSATLEGLAYVVMDEVHYLADRFRGGVWEEVIIHLPASVTLVSLSATVSNAEEFADWLITVRGETTVVVSEHRPVPLWQHMLVGKRMFDLFHDAAAARKHDVHPELLRYTRETVRRLDLGEGRAAGWGGRRGPRWRGPSRPDIVERLDREGLLPAILFIFSRAGCAAAVQQCLAAGLRLTSPEERAEIRRVVESRVTAIPGEDLSVLGYWEWLDGLERGLASHHAGMLPVFKEVVEELFVRGLVKAVFATETLALGINMPARCVVLERLVKYNGEAHVDLTPGEYTQLTGRAGRRGIDVEGHAVVVWSPETDPRHVAGLASTRTYPLRSSFRPSYNMAVNLVGSVGADPARALLESSFAQFQADRSVVGLARQVQRNTETIEAYGVEAECHHGDFDEYFALRVSIADRERALARQGQSQRRAAAVAALERLRVGDVIRVPSGRRAGLAVVLDPAAGGFSEPRPLVLTQDRWAGRISPGDFTTPAEVLARIRVPKHFNPRNPAARRDLAAQVSGTGLDRHSRRGARGRQSGEDHQLTQLRAELRRHPCHACPEREEHARWAERRRRLERDTEELRERVAGRTGSLARTFDRIVALLTTRGYLTAEGEVTDAGRMLGRIWTEADLLVAECLRRGVWDGLSPAELAAAVSVVVFEARRDVDERASLPRGPVAEAVDATLKLWSEIEADEAARGLTVTREPDLGFAWPIYRWARGEALAKVLASGHELDGEMPAGDFVRWARQVVDLLGQVADSGGASAELRATARQAIGVVNRGVLAYHAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6X0</accession>
    <name>F4F6X0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_22725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734297.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22725"/>
    <dbReference type="EnsemblBacteria" id="AEB45645">
        <property type="protein sequence ID" value="AEB45645"/>
        <property type="gene ID" value="VAB18032_22725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22725"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="AFTYLVQ"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="358"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="602" mass="61513" checksum="14B68A3691EEE74A" modified="2011-06-28" version="1">MTGVRRTTWDALRARRRPLGRLAAWSVAESLPALLSGLIVARAVDRGFLAGEFGTGLAWLAGLAVAVLVGAVATGRVYRSLGAVVEPYRDELAARVVDGALREATRAGGRPDSAAVARLTQQVEVVRDTFGGLLLVVRGFLFSAGAALLGLLALSPPLAAAVAAPLVLGLTVFAAALPSMVAHQRAQVAAGEELGRSAAAALTGHRDVTACGGQERVVAAVDRRVVAQADAERTLARMAALRSLSLGLGGWLPVVVLLLAAPWLVGRGLSTGAVLGALVYVTTGLQPALHALVQGVGGGGLRYAVTLDRILRGCPPTDPSAAAGRTAATAGGGTAGGGTAGGGTAGGATADGGVVPAVRVRGLTFRYGPHARPVLADFTLTVAGGEHLAVVGPSGAGKSTLAALIAGLVPPDSGSVHLADTPVAAVAPETLARLRVLVPQEAYVRSGTLADNLRYLRPDADQATVAAAVDALGAGPLVERLGGLAAEVEPGRLSAGERQLIAAVRAYLAPAPLVILDEATCHLDPTLEATVEEAFARRPGSLVVIAHRISSAIRARRVLVFDDDRPLAGSHEELLRRSPTYRELVGHWQELTIPAHRPLTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Y1</accession>
    <name>F4F6Y1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pup--protein ligase</fullName>
            <ecNumber evidence="2">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pafA</name>
        <name evidence="4" type="ordered locus">VAB18032_22780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734308.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22780"/>
    <dbReference type="MEROPS" id="U72.001"/>
    <dbReference type="EnsemblBacteria" id="AEB45656">
        <property type="protein sequence ID" value="AEB45656"/>
        <property type="gene ID" value="VAB18032_22780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22780"/>
    <dbReference type="eggNOG" id="COG0638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040524_0_1_11"/>
    <dbReference type="OMA" id="CVSQRAE"/>
    <dbReference type="OrthoDB" id="537546at2"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="452" mass="51854" checksum="E7B2E7AEC4E00C31" modified="2011-06-28" version="1">MERRIFGLETEYGVTCTYRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDSVIDLVAHDRAGERILEGLLIDAEKRLHDEGIAGEIYLFKNNTDSAGNSYGCHENYLVSRHGEFGRLADVLIPFLVTRQLICGAGKVLQTPRGAVYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMNEVTTLLKVGSADIVLRMIEAGVVMRDLTLENPIRAIREVSHDITGRRKVRLASGKEISALEIQQEYLAKATEFVERRGGDQTAKRVVELWGRVLRAVETGDLEPVSREIDWVTKLRLIERYQRKHDLPLSHARVAQMDLAYHDLRRGRGLYALMERRGDVDRVATDPEIFEAKETPPQTTRARLRGEFIRHAQEKRRDFTVDWVHLKLNDQAQRTVLCKDPFRAYDERVERLIASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Y3</accession>
    <name>F4F6Y3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 6">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_22790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22790"/>
    <dbReference type="EnsemblBacteria" id="AEB45658">
        <property type="protein sequence ID" value="AEB45658"/>
        <property type="gene ID" value="VAB18032_22790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22790"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_11"/>
    <dbReference type="OMA" id="RRNWIDA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="32353" checksum="BE885B38CA63A1EC" modified="2011-06-28" version="1">MLAGGTGSRLWPITRAVSKQLMPVFDKPMIYYPLSTLVMSGVREILVITTPDEQAQFQRLLGDGSQFGLRLEYVAQPRPEGIAQAFVLGADFIGDEGVALILGDNIFHGVGLGRQLAAAGDPVGGRIFAYPVANPQAYGVVHFAPDGRVLSIEEKPDQPRSRYAVPGLYFYDNRVVEIARGLTPSSRGELEITAVNEAYRRWGELSVTVLDRGTAWLDTGTFTSLMQAAEFVRVIEERQGMKIGCIEEVVWRAGLIDDDQLRALAEPLTKSGYGDYLLDLLAGERHELISPGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7I1</accession>
    <name>F4F7I1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_16580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733080.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16580"/>
    <dbReference type="EnsemblBacteria" id="AEB44420">
        <property type="protein sequence ID" value="AEB44420"/>
        <property type="gene ID" value="VAB18032_16580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16580"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008878_4_2_11"/>
    <dbReference type="OMA" id="NLPAWIC"/>
    <dbReference type="OrthoDB" id="365211at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="2">
        <location>
            <begin position="177"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="3">
        <location>
            <begin position="413"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="555" mass="61723" checksum="26C1335E34A553FF" modified="2011-06-28" version="1">MAHSSKPEPVDAIVVGLGATGGTAVKVLAEAGMKVVGFDRGPWLRAHEHYSGDEVKYVNRNYLWPDPKLFPRTLRHDENSVAEVFPFSPTPQLVGGGTNHWAGWVPRPRESDFIQRSLHGDLPGASLADWPIRYEHLEPYLTKVEWEFGVSGVAGADKYEPFRSRPYPSEPLRPTRFGRRFYDAAKKMGFNAFPIPHAMVTNRHKGRDPFNKTSFWNQYGDPSGARSNTLTTFIPEAVATGNFELRSECFVREIKVGKDGRATGVVYIDPEGREVEQDAKVVVLSLGAIESARLMLMSRSATHPDGLANSSGLVGKNATFHEYVFAVGLFDKEVDDPLYGWAGNYISGGTFEFYETGKDRGHIGGCLISASQTVHPVNWVFPGRPSWGSALKDADRDYFNYAMKIGAILHDMPRESNRVDLDPTVKDAWGLPVARITHQPHENDVRMSKWQVDKNAEILEVAGARKTVPVYLDRMTGNTCHQHGTARMGNDPTKSVLNEWCQTHDIDNLFVVDGAGFPTSTGVNPTLTMMANAWRACEYIVETYAKGREEHIKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Y4</accession>
    <name>F4F7Y4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46959">
        <property type="protein sequence ID" value="AEB46959"/>
        <property type="gene ID" value="VAB18032_29441"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29441"/>
    <dbReference type="eggNOG" id="ENOG5031QZB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151362_0_0_11"/>
    <dbReference type="OMA" id="RACGGPW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307717" evidence="2">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="142" mass="15796" checksum="E622FFF6E1034C44" modified="2011-06-28" version="1">MRVRCYQRPKLLGLAMVGGLVLAASGNREAAVISTRLPAPGRGPRPERPRATGGDPPHTPLRPMWCCRADGQPWPCAQARLLLRAEYDENPVGLSIYLAGLMYEAMRDLYRLNPYDGPEPAALFDRFLAWGPRRRPPSEQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F874</accession>
    <name>F4F874_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731906.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10585"/>
    <dbReference type="EnsemblBacteria" id="AEB43235">
        <property type="protein sequence ID" value="AEB43235"/>
        <property type="gene ID" value="VAB18032_10585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10585"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_1_11"/>
    <dbReference type="OMA" id="YIPGRIG"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="157"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="42572" checksum="24CE1EEAF02E2EFE" modified="2011-06-28" version="1">MRLPDSFYTSVRTRLSEALDERGLDGYLATSPPEVAFLSGFFYIATERPVYLWMPREGEPLLVIPRLDEEYAAQQGVTMPMVSYFEYPGVVSAEETLAAALSRPGGAGRRIGVSAGVSVAAFRALSGAIGGAELVTTDAVAKLRLCKFPEEIPFHEAAARICDEMLAAGRGLIEEALASGGPLPREDEIARHVIGYGTDQMYAHYDLVVYTTKLAGGLVYAGPNSALPHGLPTRRRVRPGDTLILSLGAAVASRFVESERTFIIGEPTAEQVRYYEADRQAQEVGTQAMIAGRTCAEVNKTCLDVLRDQGLGDYIRHRQGHGIGLQNHEAPWVEDGDHTVLAPGMLLSSEPGVYVPGHAGYRISDTVLVQQDGPRRLTGYPRDLASNIIEGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8H8</accession>
    <name>F4F8H8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Modular polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_17095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733178.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17095"/>
    <dbReference type="EnsemblBacteria" id="AEB44523">
        <property type="protein sequence ID" value="AEB44523"/>
        <property type="gene ID" value="VAB18032_17095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17095"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_35_8_11"/>
    <dbReference type="OMA" id="HNERCKE"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1590"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2561"/>
            <end position="2636"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1625"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="2721" mass="284198" checksum="DB158DC088016875" modified="2011-06-28" version="1">MADEQKLRDYLKRAIADSQDLRARLRAAEDQDREPIAVVGMGCRYPGGVTSPDELWDLVLAERDAVGPFPENRGWPADLVDPDPEAVGKSYAGEGGFLYDADQFDADFFGISPREAEAIDPQQRLLLEVAWETAENAGIDPESLRGTDTGVFLGSMYHDYGARPRLPGEAEGYLFSGSAGSIASGRLAYVFGLEGPTLTVDTACSSSLVALHLAVSALRRGECSAALVGGVTVMATPTAFVEFSRQRGLAVDGRCRSFGAGAAGTGWAEGVGLLLVERLSVARERGHRVLAVVRGSAVNSDGASNGLTAPSGPAQERVIRAALGVAGLSASDVDVVEAHGTGTSLGDPIEAQAVLATYGSRTGGVPVLLGSLKSNIGHAQAAAGVGGVIKMVQAIRAGVAPRSLHCEVPSPMVDWDSGAVQLLSSRQDWPDTGRPRRAAVSSFGFGGTNAHVILEQAPESEPTDEPAAGERPQRIPLLLSARGPAALADTARRIADLLTDPDTDPLDVAGSLATGRAALTHRAAVLGTQSADLRQALLALAEDRPHPAVHRGTRSSGKTVFAFTGQGSQWVGMGEGLVGVFPVFRRVWEEVCSRLVWDAGDVDATGNAQPAIFAVEVALFRLLESWGVRPDVVVGHSVGEIAAAHVAGVLSLSDACRLVGARGRLMQALPAGGVMVAVQASEEEVVPLLTDGVSVGAVNGPRSVVLSGVAGAVESVVGRLSCRSRSLVVSHAFHSSLMDPMLDEFRAVVRELSFGRPVVSAVSTVTGEPVTAQWSDPEYWVGQVRSTVRFHDAIRTAHRLGARTLLEIGPDAVLSGLAADTLTTISTLRRDQPEPDAVRTAAATLWATGAGIDRPAILADTGTRRHALPTYPFQRRRYWMHPASGVDAGLRPAGHPLLTAAVTLAAGDTTVFTGELSTTTQPWLADHRLHGTVVLPGVALADLLATVGARTGHPHLVDLVTTTPVTLPGDQPLDLQVTVTGHDDGRCTAEVFTRPAATDDTPWQRHATAVLDDTPPDEHPDTRVPAAATEIDLDDLYDRLTEHGYDYGPQFRGLQRLHRHGDDLYAEITGPDNTGFTVHPALLDAALHPLLPGVAADSPARLPFAWAGVHLAGTRATILRARITPLGPESVRLTVTDDTGDPVATVRQLTLRPADPDQFRPSVTDLRYRPQWQPHPAPGHAPAANADGTAPPDLLIVRVAATGPGSPATRARTAVHDTLAVLRDHLTGEPGPRLVVVPPADDPLTAAAVAGLVRSARTENPGRVVFVDTDDTDASRTALLREALGDEPDLRIRDGEVMVPRLVPAGPAPQTTPDWGDGTVLITGGTGALGAALARHLATRHGVRDLLLVSRTGPEAPGVADLTTELTGLGARVHVAACDVTDRTALAGLLDRHPALTAVVHAAGISRDGVLASLTADQVDEVLAAKADAAWHLHELTADRPLTAFVLYSSIAGLIGPAGQAAYAAGNAFLDELARHRQAAGLPATSIAWGLWQDGGTMSATLTDTDLSRIARLGLRPIDTADAMTALDAAVASTDPVLAVTAVDPTLLRTSTDVPAVLHSLAPGRRAPRRDRGPASIRRIAAMNPPDRDRALANLVRTHAAAVLGHDDPAAIDLDRTVSDLGFDSLTGVELRNRLATATGLTLPATLIFDHPTPAALAEHLASRLTDTAPAAEQTVAPVVVADEDPVVIVGMGCRFPGGVSSADELWDLVVAEKDAVGPFPVNRGWPADLVDPDPEAVGKSYAGEGGFLYDADLFDAEFFGMSPREALATDPQQRLLLEVAWETFEQAGIDPRSLRGSDTGVFCGVMYHDYGSGPGTLPAEVEGYLAGGTMGSVASGRLAYVYGLNGPTLTVDTACSSSLVALHLAVSALRRGECSAALVGGVTVMATPTAFVEFSRQRGLAVDGRCRSFGAGAAGTGWAEGVGLLLVERLSVARERGHRVLAVVRGSAVNSDGASNGLTAPSGPAQERVIRAALGAAGLSASDVDVVEAHGTGTSLGDPIEAQAVLATYGSRTGGVPVLLGSLKSNIGHAQAAAGVGGVIKMVQAIRAGVAPRSLHCEVPSPMVDWDSGAVQLLSTRQDWPDTGRPRRAAVSSFGIGGTNAHVILEEPPAVETEPAADDPTPPGTDRPVPIVVSAATPQALRAHLDQLADHPIGQPADLARSLLTGRALLAHRAVVAAADPSTLTTALRTATPVTPPRPGRTAVLFTGQGSQWVGMGEGLVGVFPVFRRVWEEVCSRLVWDAGDVDATGNAQPAIFAVEVALFRLLESWGVRPDVVVGHSVGEIAAAHVAGVLSLSDACRLVGARGRLMQALPAGGVMVAVQASEEEVVPLLTDGVSVGAVNGPRSVVLSGVAGAVESVVGRLSCRSRSLVVSHAFHSSLMDPMLDEFRAVVRELSFGRPVVSAVSTVTGEPVTAQWSDPEYWVGQVRSTVRFHDAAQRLLADDVTTLIEVGPDAILTGMLAAHLPDGVAALPTLRRDRPEPQAAAELFGHLYAYGQPVDPDTYPPVAAGTRIPLPSYPFQRERYWLLRDAATTTAVPEPKSTPAPAVDLTGLDDDARADRLLALVRTEAATVLGHGDPTRLGADRAFTDLGFDSMTAVELRSRLSTALGIPLPATAVFDHPTPRSLAGLLLDQYATAAPAAPDDLDLLAEVDRLDAALARNTLTTDRRTAVLVRLGEVLARRSPTEPGPEPDLLHSADADELFAFIDDQLGRAARPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8I9</accession>
    <name>F4F8I9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733189.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17150"/>
    <dbReference type="EnsemblBacteria" id="AEB44534">
        <property type="protein sequence ID" value="AEB44534"/>
        <property type="gene ID" value="VAB18032_17150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17150"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026278_1_0_11"/>
    <dbReference type="OMA" id="GMFGWSK"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309165" evidence="5">
        <location>
            <begin position="30"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="391" mass="42225" checksum="06D092DCD23581DF" modified="2011-06-28" version="1">MTSALTRRRLLAAALATGVAVPLGDRGRAAPASPGPTRITLPPPTGPHRVGTVSLHLVDGSRPDPVAGAGHHRELMASVWYPAVGNVRRHPVVPWMPAAPLRALLVSAGFDADAAAAPRTAGHEGAAALRAPARLPVIVFSHGNDGHRAEATIVVQELASHGYVVVTVDHTYDAFSVFPDGRLTVPEDLSFTPWDHARDIRFVLDCIEDLAAGRNPDVRGRPLPASLGAAFDLRRIGMFGWSKGATATALVMNQDRRVRAGLGFDGPMQSVPPVAEIDRPFMLMTAEFTRAAEPSIAQFWSNLHGWRLNVQADGAAHSSYCDNQWLIPQLARIIGMSDEDLAGWIGTLDPARAVRIQQAYPLAFFDLHLRHQRQHLLEGPNPAFPEVQFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8K8</accession>
    <name>F4F8K8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734403.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23265"/>
    <dbReference type="EnsemblBacteria" id="AEB45751">
        <property type="protein sequence ID" value="AEB45751"/>
        <property type="gene ID" value="VAB18032_23265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23265"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="OMA" id="LWGIQIA"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="325" mass="34431" checksum="5B68EE687A1316FF" modified="2011-06-28" version="1">MRAIVQDSYGPADVLRLGEVDRPRVGDDEVLVQVRAAAVDPGVWIFMVGQPYLVRLASGLRRPRVTVRGRDLAGVVAEVGARVTRFRPGDEVFGTCLRGSYAEFASTSARRLAHKPANLSFAQAAAAPVSGLTALRAVRDSGKVRPGQRVMVIGASGGVGSQAVQIAKAYGATVTGVCAPAKADLVRSLGADDVLDYTREEVDRDGPVYDVVIDTGGDRPLSLMRRALTPRGTLALVGGTYTRGGLLGGYGRQMFGAPLLSLFVGHRLRNVSAVERSEDLDELRELIASGALTPPIDRCYPLAEAADAIRHLRTGHPAGKIVVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Q8</accession>
    <name>F4F8Q8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_23515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734453.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23515"/>
    <dbReference type="EnsemblBacteria" id="AEB45801">
        <property type="protein sequence ID" value="AEB45801"/>
        <property type="gene ID" value="VAB18032_23515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23515"/>
    <dbReference type="eggNOG" id="ENOG502ZNMN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1293165_0_0_11"/>
    <dbReference type="OMA" id="MAPVAFR"/>
    <dbReference type="OrthoDB" id="2031756at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312798" evidence="3">
        <location>
            <begin position="26"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="21929" checksum="30BCF5593A6FAB9C" modified="2011-06-28" version="1">MRLSRIIMALTVGLAVVAVPAVAGAAQPQPSPSPTVTDPPQPPPYPPNLVTTLTVNRPTIFLGETVILTGRNFGPNETVDIVVTAQPLAAPAAGTARRSDGSTVAMTPVAFQAAAVDRFTARTNAAGVFTRRYTPRVTGLLTFTATGRESDRSASTELRVLHKKKPHLPVTGSSLGTPMKVGGGLVAAGGVMLLGAMLWRRRNRFGAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8U7</accession>
    <name>F4F8U7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735675.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47027">
        <property type="protein sequence ID" value="AEB47027"/>
        <property type="gene ID" value="VAB18032_29781"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29781"/>
    <dbReference type="eggNOG" id="ENOG5030IIX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159338_3_2_11"/>
    <dbReference type="OrthoDB" id="2035941at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="7008" checksum="C4B2F22F17A680E8" modified="2011-06-28" version="1">MTDRGGALPDYLAGLDYPVSREDLIRWCQENGASTEQLQAVRALPVEQIGSAAELSDALPAPWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8V0</accession>
    <name>F4F8V0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735678.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29796"/>
    <dbReference type="EnsemblBacteria" id="AEB47030">
        <property type="protein sequence ID" value="AEB47030"/>
        <property type="gene ID" value="VAB18032_29796"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29796"/>
    <dbReference type="eggNOG" id="ENOG5032RMD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122776_1_0_11"/>
    <dbReference type="OMA" id="FPDETVW"/>
    <dbReference type="OrthoDB" id="1956639at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="135" mass="14300" checksum="197AC345DC322AA6" modified="2011-06-28" version="1">MAETRTEQPVRTNTGPGRLLIAVYLIFAIAATSRATLQIVTRLDEAPLAYLLSALAAVVYIVAAVGLARAGHAGRRVALACCAVELVGVVGVGAFSLVRPDLFPDETVWSGFGSGYGYIPLLLPVLGLAWLYRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Z3</accession>
    <name>F4F8Z3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nickel-containing superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735721.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30011"/>
    <dbReference type="EnsemblBacteria" id="AEB47073">
        <property type="protein sequence ID" value="AEB47073"/>
        <property type="gene ID" value="VAB18032_30011"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30011"/>
    <dbReference type="eggNOG" id="ENOG502ZR3M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141681_0_0_11"/>
    <dbReference type="OMA" id="AHCDGPC"/>
    <dbReference type="OrthoDB" id="1789560at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02753">
        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="134" mass="15298" checksum="681BF44FBFD29051" modified="2011-06-28" version="1">MRLARILAPRLTASAHCDLPCGVYDPAQARIEAESVKMICEKYQANTDPEFRTRAILIKEQRADLVKHHLWVLWTDYFKPPHFEKYPHLHQLFNEATKLAGAAGAKGATDPAKADELLQKIDEISKIFWETKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F912</accession>
    <name>F4F912_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730714.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04570"/>
    <dbReference type="EnsemblBacteria" id="AEB42040">
        <property type="protein sequence ID" value="AEB42040"/>
        <property type="gene ID" value="VAB18032_04570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04570"/>
    <dbReference type="HOGENOM" id="CLU_2771310_0_0_11"/>
    <dbReference type="OMA" id="HMTANVH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="72" mass="7434" checksum="AB06CD9B94407BB0" modified="2011-06-28" version="1">MSAANVAVSVHVRADIALSFRSHPAEDRVVVQLGDTGGEVVLFLPRAEIDRLAGVLAAARESLTVPAVKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F934</accession>
    <name>F4F934_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730736.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04680"/>
    <dbReference type="EnsemblBacteria" id="AEB42062">
        <property type="protein sequence ID" value="AEB42062"/>
        <property type="gene ID" value="VAB18032_04680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04680"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_2_2_11"/>
    <dbReference type="OMA" id="EWQYACK"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="24129" checksum="40D527FE83820C7E" modified="2011-06-28" version="1">MISISAGQVTLSDRRTQRRWSVRLQPYDIAAVPVTQEQYAQVTGERPSAATGDRLPVESVSWWDAIRFCNALSQRDGLTAAYRLDGDQVGWNVDADGYRLPTEAEWEYACRAGTTGPRYGPLDEIAWYRGNSAERIHEVGGKQPNTWGLYDMLGNVWNWCWDVYDAEMYGSYRVLRGGGWFDEQWSCRASVRRRSHPTFTVDDVGFRVARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F979</accession>
    <name>F4F979_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04905"/>
    <dbReference type="EnsemblBacteria" id="AEB42107">
        <property type="protein sequence ID" value="AEB42107"/>
        <property type="gene ID" value="VAB18032_04905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04905"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_2_2_11"/>
    <dbReference type="OMA" id="MFDELCP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="13792" checksum="509FB926C4CD91FB" modified="2011-06-28" version="1">MFDELCPSSLTPIRFGDKWAALIIRCLEHGPRRFSELRVPLRRVTPKVLTQSLRSLERDGLVKRTVYAELAPHVEYELTPVGRSMLEPMAVACAWAEQHWNELLDARESYDNATRLDRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA25</accession>
    <name>F4FA25_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735782.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00260"/>
    <dbReference type="EnsemblBacteria" id="AEB47136">
        <property type="protein sequence ID" value="AEB47136"/>
        <property type="gene ID" value="VAB18032_00260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00260"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350184_0_0_11"/>
    <dbReference type="OrthoDB" id="308727at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="872" mass="92619" checksum="323BAFF11783A6A1" modified="2011-06-28" version="1">MGGRILELRVHGVSNTPPADTLGLGSTPGGEAPAPQLVAGGPITGFYRSATSTPLDPIAVEAYSWGQLTSGARTARDVERALWTLLLPFTLANVALHARPGIPPDPNTERLASRSGITAWLIRMFCLSLTCTPVFALTTVGVDLIAWQCVDSACLNRLPGPWDFLANPWWRQSGRSLAAGLIVPLALIAVLGIVAWRTYQYEAVMPADPMDPPVHHTPGPVDAELPDAQPVPEPPPPPTPTGPLASPLQDPTFWWGEGQLRRAAVLHLCTGTVVAAAIPLGTVLVLSPPHGTQAVIAWTSVLVLVAVVVITLVALTLPSLTRRDGATPLGRWSIAVIVLTVTGLTGTVLVLMLPDTGASLAALRPPPGCANLATQPGCLEDHSLPGIDRIAAWFVTGQLLLLIAIGATSRSGRRGGAAPAVATVLLVAGAAWSHGWLPAVPAAPLEVWQIALPLLLLAATGLLLPRTRIAEGKQPLGPYTDLTWRGQAPAVIAGFGWLLCLAYCAGLLYWVTNRLNGGSVPSGAAPVTPPTPVTWGGLLFGAALLMLAVIVIRAIVLFRRLHRTEYAKLAASGPLSAHDLRRGRDVSTHRALHRLVGEHALGLIGWYAAALLVLAVVGCVAVLSPAPPHPDPATGSSAVMIKLVADLGDALLGWLPVTIAAMGLLVYRNNTVRRSVGVVWDVGTFWPRAAHPLAPPSYAERAVPELLTRTAGLLALAEHDPRRVDGIILSGHSQGTVICTAVLLQLPERWRRQIWFFSYGCQLTRLYGRIFPAYFGPDRLPVLTEALTRSCGSIGWTNFWRDTDPLGWPVSAGERDVPVTDPEALHPSDGEVADPPIRSHSGYPEAAEFQRERSRVAWLLRRAVPSPRRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA79</accession>
    <name>F4FA79_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730814.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05070"/>
    <dbReference type="EnsemblBacteria" id="AEB42140">
        <property type="protein sequence ID" value="AEB42140"/>
        <property type="gene ID" value="VAB18032_05070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05070"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019886_0_0_11"/>
    <dbReference type="OMA" id="DRVPHQV"/>
    <dbReference type="OrthoDB" id="989319at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="612" mass="64215" checksum="B7AB527CD63C7123" modified="2011-06-28" version="1">MTTNGDPASLSGAPAVAARTGRTDAGEDRPAADDRLPDALSGLRAAIGAATFPLVLPSAEPAERIGAALADQLDDYLLPRLTRLDAPLLVVVGGSTGAGKSTLVNSLVQARVSAAGVLRPTTRSPVLVCNPADSSWFRRGELLPGLTRTNQPSDDPRTLHLVTAPALAPGLAFLDAPDIDSVVDANRALAGQLLAAADLWLFVTTAARYADAVPWELLRGARARGAVIAMVLDRVPAEATDEVAGHLAEMLAEQDLGSAPLFVLPETWVDGQGLLPARVTAPLADWFARLAADADARSAVVRQTLGGALIALQPAVESLAAAADEQVAAADTLDDRVRAAYRAANRTVEQGLRDGRLLRGEVLARWQEFVGTSDFLRSLEARIGRLRDRLVAAFSRRPAPAAELREAIESQLVTLLRAVAAEAAEQAYTGWKAHPAGAALLVPDLAHHGDDLPERAERLVRDWQRGVLELVRTEGGDRRFVARTAAYAVNATGLAVMIAVFASTAFIPTGLEVATGAGTTLAGQAVLQAIFGDQAVRTLADKARADLLERVRALLDAEAARFLSRTEQARPAEQTATALRQAAERVEAARLASGFADATSALSGPADQGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA87</accession>
    <name>F4FA87_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpB</name>
        <name evidence="13" type="ordered locus">VAB18032_05110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730822.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05110"/>
    <dbReference type="EnsemblBacteria" id="AEB42148">
        <property type="protein sequence ID" value="AEB42148"/>
        <property type="gene ID" value="VAB18032_05110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05110"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_11"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="414"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB42148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="863" mass="93886" checksum="F92777AEFEBDE051" modified="2011-06-28" version="1">MNTERLTTRSRETITGAVALANQRGHATVEPWHLLLSLLDTEGSTAAGLLRAVGADPAELRRVTQRALDALPAARGSSIAEPTLAREFVNAIGAAEQIARPLGDEYTSTEHLLAGLARVGGAVSGALKAAGATEETLVAAFPKVRGGDRRVTSADPEQTYQALAKYGVDLTASARDGKIDPVIGRDSEIRRVIQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKKLVSLDLGAMVAGASYRGQFEERLKSVLEEIKNSDGQVITFLDELHTVVGAGKGEGSMDAGNMLKPMLARGELRMVGATTLDEYREHIEKDPALERRFQPVLVGEPTVEDTIGILRGLKERYEVHHGVRITDAALVAAAALSDRYITDRFLPDKAIDLVDESASRLRMEIDSRPVEVDEIERAVRRLEIEEMALAKEPDAASAERLERLRKELADKREQLTALSERWKLEKTHITKLSTAKEELERLGGEAERAERDGELERAAELRYGRIPALNNELKQAAEELARLQADGAMLKEEVGADDIAAVVASWTGIPAGRLLEGETAKLLRMEDSLRERVVGQAEAVGAVSDAVRRARAGVADPDRPTGSFLFLGPTGVGKTELAKALAGFLFDDERAMVRIDMSEYGEKHSVARLVGAPPGYVGYEEGGQLTEAVRRRPYSVILLDEVEKAHPDVFDVLLQVLDDGRLTDGQGRTVDFRNAILILTSNLGSSVISDLTLAEEQRREGVLAVVRSHFKPEFLNRLDDIVVFAALQGDDLRAIVDIQIARLRRRLADRRLTLDVTDAARTWLAEHGYDPIYGARPLRRLVQSAIGDQLAKALLAGKIRDGDTVRVDLADTKDGLSVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAD0</accession>
    <name>F4FAD0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_05325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730865.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05325"/>
    <dbReference type="EnsemblBacteria" id="AEB42191">
        <property type="protein sequence ID" value="AEB42191"/>
        <property type="gene ID" value="VAB18032_05325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05325"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_1_0_11"/>
    <dbReference type="OMA" id="ASSCEKI"/>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="366"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB42191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="474" mass="51833" checksum="71D4679211FD6A9B" modified="2011-06-28" version="1">MTTIPNVLANRYASPELVALWSPEEKIRLERRLWLAVLQAQRDLGVSVPDGVVEAYERVLDDVDLDSIAARERVTRHDVKARIEEFNALAGHEHVHKGMTSRDLTENVEQLQVRRSLELIRDRVVATLARLAWHAHEYADVVMAGRSHNVAAQATTLGKRFASAAEELIIAYERLTDLISWYPLRGIKGPVGTAADQLDLLDGDAEKVAELERRVAEHLGFSRVLDSVGQVYPRSIDLAVISALAQVASAPSSLATTIRLMVGQELATEGFKPGQVGSSAMPHKMNTRSSERVNGFAVIIRGYLSMVGELAGDQWNEGDVSCSVVRRVALPDAFFAADGLFQTFLTVLDEFGAYPAVINRELERFLPFLATTKILVAAVRRGVGRETAHEAIKEHAVAVALAMREQGSPDNDLFDRLAADPRLGLSRPEIDALVADRAAFVGAAPAQIQAVTTRISKIVQSHPQAATYTPPPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAD1</accession>
    <name>F4FAD1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05330"/>
    <dbReference type="EnsemblBacteria" id="AEB42192">
        <property type="protein sequence ID" value="AEB42192"/>
        <property type="gene ID" value="VAB18032_05330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05330"/>
    <dbReference type="eggNOG" id="COG0393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123899_0_0_11"/>
    <dbReference type="OMA" id="TANEPRI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="187" mass="19966" checksum="5CA1BD09AA7E51F2" modified="2011-06-28" version="1">MGNAPAVRAALFFSIRAGERGSRCRASAAASIENVLVVTTDQLPGYEIRQILGEVVSSMARTRNPYREGVKNLRGGAYDPMAPDNLTRWRTDSVARLGEEARRLGANAVVGMRFDSRDCGEMWMEICAYGTAVIVAPKVPDVMPPDQPLIAAETANDPSFASTPGGIAEPASAPNLRTAAETPTRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAG2</accession>
    <name>F4FAG2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732060.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11365"/>
    <dbReference type="EnsemblBacteria" id="AEB43389">
        <property type="protein sequence ID" value="AEB43389"/>
        <property type="gene ID" value="VAB18032_11365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11365"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_2_11"/>
    <dbReference type="OMA" id="GPYTYGR"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044540">
        <property type="term" value="F:L-cystine L-cysteine-lyase (deaminating)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="379" mass="39607" checksum="46CF7AA7A6E36B42" modified="2011-06-28" version="1">MSENEVPQRLPADGDGTRCVRAGLPAPQPGQPFLPGPVFAAPYHLDPRHGPEAAPNGYGRPDNPTRRLLEAAIGELEGGECRVFASGQAAITGLLLGLLRAGDAVVLPADGYFPVRAFATDTLTGNGVRVLLAPTAGPYPSFDGVRLVLVETPANPGLDVVDLPALAERVHAAGALLAVDNTTATPLGQRPLDLGADLVVASGTKALTGHSDLLLGYLATRSAELVERFTAWRTNTGAVPGAFDAWLAHRSLATLDLRLARQSANAEALARLLADRADVTGLRWPGLPDDPAYPVASRQLRRMPGVLSFDLGDAERVARFLDATRLVSAATSFGGLHTTADRRAQWGDDTTAGFVRLSCGVEDTVDLIADVSAALDASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAU1</accession>
    <name>F4FAU1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fuconate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_24030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:22772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:21291"/>
            <dbReference type="ChEBI" id="CHEBI:37448"/>
            <dbReference type="EC" id="4.2.1.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.68" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734556.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24030"/>
    <dbReference type="EnsemblBacteria" id="AEB45904">
        <property type="protein sequence ID" value="AEB45904"/>
        <property type="gene ID" value="VAB18032_24030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24030"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_2_0_11"/>
    <dbReference type="OMA" id="LLMMDAN"/>
    <dbReference type="OrthoDB" id="743369at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="7">
        <location>
            <begin position="196"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="433" mass="47139" checksum="965FF75BF7ED010E" modified="2011-06-28" version="1">MTTITDVTVHDVRFPTAASGDGSDAINRGDYSATYVELSTDDGPTGAGFTFTNGRGNEITCAAVDALAHHVRGRTVQEITAEPVAFWRSLVADVQLRWLGPEKGVIHMATGALVNAVWDLRAKLAGKPMWRYLAEMPTDELVANVDFSHITDALTPDEAAAILDKGRDGLADRLAVLERAGFPSYTTSVGWLGYPDDKVRALTREAYAAGWRAMKMKVGGPPADDLRRARIIRSEIGPDALLMMDANQVWDVDEAITNMTALAEVDPYWIEEPTHADDILGHARIARAMTELTGGRCRVATGEVAANKVIFKQLLQAEAIGVMQIDACRVAGVNEVLAEILLAAKFGVPICPHAGGVGLCEYVQHLAIFDYLRVGTSLDGRMVEYVDHLHEHFVDPVRTRDGRYLLPTAPGYSATMHPSSIATFRFPDGPTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB34</accession>
    <name>F4FB34_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00475"/>
    <dbReference type="EnsemblBacteria" id="AEB47179">
        <property type="protein sequence ID" value="AEB47179"/>
        <property type="gene ID" value="VAB18032_00475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00475"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069543_0_1_11"/>
    <dbReference type="OMA" id="GPGLMAK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="261" mass="28504" checksum="2E44B6CF8C4B7409" modified="2011-06-28" version="1">MPDHHTGGGDPAHTLRLLWRRTEDGPRRGPRQGRSLDDIVRAAIELADREGLDAVTMRALAKAVGVAPMTLYTYVPGKAELLDLMLDALYADMPRPDRSGEPWRTRVAALAQDNRELFAAHPWAAEVATGRPPLGPGLMAKYEYELRAFDDTGLDDVTRDAALTFVLDFVRAAARSAAEARSARQASAWTDEQWWTANAPLLAEVLDERRYPTAVRVGAAAGAAHNAAYHPDHAYTFGLTRVLDSLTTLINPPPSPTHPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB58</accession>
    <name>F4FB58_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00595"/>
    <dbReference type="EnsemblBacteria" id="AEB47203">
        <property type="protein sequence ID" value="AEB47203"/>
        <property type="gene ID" value="VAB18032_00595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00595"/>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139648_2_0_11"/>
    <dbReference type="OMA" id="RFSELGQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010958">
        <property type="entry name" value="Chorismate_mutase_highGC-bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01808">
        <property type="entry name" value="CM_M_hiGC-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="116" mass="12314" checksum="9306187D5E4D43C3" modified="2011-06-28" version="1">MEQSGVPAGSGMAPDRTGAAGTPDSAKPGTGTTEPMAAARIVEIRTRIDEIDRTLIELWQERAELSREVGATRMASGGTRLVLSREQEILERFRSALGADGTQLALLLLRAGRGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB62</accession>
    <name>F4FB62_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735852.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00615"/>
    <dbReference type="EnsemblBacteria" id="AEB47207">
        <property type="protein sequence ID" value="AEB47207"/>
        <property type="gene ID" value="VAB18032_00615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00615"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_11"/>
    <dbReference type="OMA" id="QIFKHHC"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="107"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="336" mass="36539" checksum="8A72B0BCF2FF6A40" modified="2011-06-28" version="1">MGRYVIRRLLQFIPTVLGTMFLLHYMTSLAIQFSGNPVRAIFGDRTPPPALLQAITERLGYGDPCLDQKGNPCFGLFLDRLQNIFFHFDFGINLRQRPVTELVADAIPFTLKLLVIAIVFEAVVGIAAGVLAGLRGGSFLDYMVKISTVFIISVPIFVLGVVVREFVGVKFGNILRGQDWIPDLISVGVFTPGFKPDYPFASLIIPGMVLGAVSLATTARLTRTSIMENIRADYVRTAKAKGLTNKRVIGVHTLRNSLIPVITFLGVDIGAAMAGAVVTETIFNVPGIGRLVTFSARTGESSVVVGVVTMLVLVVLVANLLVDLLYAVLDPRIRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB83</accession>
    <name>F4FB83_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ordered locus">VAB18032_00720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735873.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00720"/>
    <dbReference type="EnsemblBacteria" id="AEB47228">
        <property type="protein sequence ID" value="AEB47228"/>
        <property type="gene ID" value="VAB18032_00720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00720"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_11"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="102" mass="10955" checksum="FE3F14E894F823C7" modified="2011-06-28" version="1">MTTATKVAIKPLEDRILVQANEAETTTASGIVIPDTAKEKPQEGTVLAVGPGRFDDDGDRIPMDVKVGDTVLYSKYGGTEVKYAGEEYLVLSARDVLAIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBG9</accession>
    <name>F4FBG9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="34376">
        <property type="entry name" value="VmaORF5690P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42265">
        <property type="protein sequence ID" value="AEB42265"/>
        <property type="gene ID" value="VAB18032_05695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05695"/>
    <dbReference type="eggNOG" id="ENOG502ZCM5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796796_0_0_11"/>
    <dbReference type="OMA" id="GWGHHHC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018578">
        <property type="entry name" value="Restrct_endonuc_II_BstXI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09552">
        <property type="entry name" value="RE_BstXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="348" mass="39139" checksum="B683675C2EA62591" modified="2011-06-28" version="1">MPKSTRSRLPRLPALAEQKLTKTGYTRGATQREIYQNRVTRNNPVLIARELWPLCRKPDDGSEAYENGFIVLVEPSWYFVVEEPDKLLAAEGLELGVNALLLYQRRVDWANYAPANGLLPNGKPFRPGVSRRNPLGGVFLARIHATVSSDGMQVVEGYKSTAQRGAGIRVYEYASSDTIQKARLQLEALMWLCRDSAEQLVAAGMPLADVRKRKSEQLARAQEQKLLDLARLRALRIINDDDCATCPLCLAEISAGDFFKRSQQAEGRSTYDLTTTEVSLFHIQELRVGKLQHKTYNLGWGHHHCNTVAKDAGIMPTLQWMKSVMDRQPNVALADEARLVEEAVEHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC26</accession>
    <name>F4FC26_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24630"/>
    <dbReference type="MEROPS" id="S12.003"/>
    <dbReference type="EnsemblBacteria" id="AEB46024">
        <property type="protein sequence ID" value="AEB46024"/>
        <property type="gene ID" value="VAB18032_24630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24630"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_2_3_11"/>
    <dbReference type="OMA" id="RANRYEY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307611" evidence="1">
        <location>
            <begin position="42"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="41978" checksum="CE62D22A3D37ADFE" modified="2011-06-28" version="1">MHTIGKSTGIRTGRRVTAALTAVAIVGFAAVGVRLADPAAAKPATDTVQAGLNELVRAGVAPGALASVRDRNGRVTHYTAGVADLRTRAKVPTDGYIRMASNTKMFTAVAVLQLVDDGVISLDEPVETYLPGLVRGNGFDGRTITVRHVLEQTSGLPDYDLPHVFEWRDRYFEARDLLDSAFAKEPTSPVPGTTMDYSNTNFILAGLLVQKVTGRPISEVITNRIIDRVGLRKTYWPGVGDQGIRKPHANGYLPHPETGKWTEITRLDPSIGGAAGQMISTPSDLNRFLVALQDGKLIKPATLAQMQTSNPFYPGGEALPDLVWHYGLGTVGFDLSCGGRAWGHGGDIDGYSSRTAITADGRAVTLVVTADSSPVPDGVFRVLDAFDAALCAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCA7</accession>
    <name>F4FCA7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplQ</name>
        <name evidence="7" type="ordered locus">VAB18032_01010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735930.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01010"/>
    <dbReference type="EnsemblBacteria" id="AEB47286">
        <property type="protein sequence ID" value="AEB47286"/>
        <property type="gene ID" value="VAB18032_01010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01010"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_0_0_11"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="19965" checksum="D5047C1DA79BCC59" modified="2011-06-28" version="1">MPTPTKGPRLGGSPAHERLMLANLATALFQHGKIQTTETKARRLRPLAEQLITKAKRGDLASRRRVLGVVKDKDVVYALFDQIAPRYTNRNGGYTRIVKTGPRKGDAAPMAIIELVEELQVTEPTANRKTAARKAAQQDKVEALAPAEEAPAARSADQDSEAPVSASGDTAAAREDSDLATEEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCJ4</accession>
    <name>F4FCJ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730994.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05975"/>
    <dbReference type="EnsemblBacteria" id="AEB42321">
        <property type="protein sequence ID" value="AEB42321"/>
        <property type="gene ID" value="VAB18032_05975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05975"/>
    <dbReference type="eggNOG" id="ENOG502ZGFU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1813582_0_0_11"/>
    <dbReference type="OMA" id="PVWLFVE"/>
    <dbReference type="OrthoDB" id="2006856at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="14799" checksum="52E6744D3959ACFF" modified="2011-06-28" version="1">MSEQQSTFPRRDAEGRIQHLGDLIGVALAGAVIGMLVLVLFDGAFAWFGAGDFGQANGWLAVILPAWLFWEDFRSWEFGAPRVVAALVAVAVAVVSGLLVAGLATGLPPLASGGLAAVTFTVVYALVWFPGVRWLVNRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD26</accession>
    <name>F4FD26_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18780"/>
    <dbReference type="EnsemblBacteria" id="AEB44858">
        <property type="protein sequence ID" value="AEB44858"/>
        <property type="gene ID" value="VAB18032_18780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18780"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123909_1_0_11"/>
    <dbReference type="OMA" id="GYPVNWP"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="162" mass="18200" checksum="3ADFC72BF3B824F9" modified="2011-06-28" version="1">MTGPLIRDRTQADLPACVQLLTEVHRADRYPLNWPADPYRWLCPARLRQAWVAVSESGDLVGHLAVQQTPDHGAEVVRLFVAPVHRRRRVGTALLRRIAQWADDQQIDLTLQVVDRAGSSAVALYEEQGWRHSGTSTADWTAADGRPVTVRHYVLSPGRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD29</accession>
    <name>F4FD29_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18795"/>
    <dbReference type="EnsemblBacteria" id="AEB44861">
        <property type="protein sequence ID" value="AEB44861"/>
        <property type="gene ID" value="VAB18032_18795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18795"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_15_11"/>
    <dbReference type="OMA" id="GFQLFAY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="367" mass="39468" checksum="E63088B2C0F3DFA7" modified="2011-06-28" version="1">MRRVGTEEWSGLAMLVVAVAVAAPGLFGAAELMIGRGWWLALFVLLLAALLTATAAPEQGRSRYVAYGVAVVAAWTLVLTARHLGLLPVLLVLTAAVSVYVVPLSVGLTVVGLNTAVIILVAVPTTRTPAELTLIVGFYLLIQLASLLSSMTLLREQRMRRELAAAHVELKAAGLRLEESARTEERLRISRELHDLIGHQLTVLTLELETARHRDGAAAREHVERADRVARDLLGDVRATVGQLRTETVDLGQALRRMARDLPGLDVSIDVSADVQVDEERAAAFVRAAQEIITNTIRHAEAQRLRISVTGDGGAAVLDAHDDGRGARRPTFGNGLRGLRERFEALGGEVVIDGSAGFRVTARVPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD69</accession>
    <name>F4FD69_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734751.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25005"/>
    <dbReference type="EnsemblBacteria" id="AEB46099">
        <property type="protein sequence ID" value="AEB46099"/>
        <property type="gene ID" value="VAB18032_25005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25005"/>
    <dbReference type="eggNOG" id="ENOG50333YK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125494_1_0_11"/>
    <dbReference type="OMA" id="HHENDRV"/>
    <dbReference type="OrthoDB" id="1666209at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="172" mass="18024" checksum="ABF017690B3C99D3" modified="2011-06-28" version="1">MDDEHTGPQTPAPGADDRLLAPLGELIRAADPPPATAVELAKQSFGLRQVDTELAALVADSALDPVGSAVRAGEQGTLPRLLTFEVEGTDDTPQAVEVEVSGSGRYRRLLGQLHPPGAARIEVRQPGGDAAAPVDADDQGRFVVAAVAVGLMRLTWHRPGRSAIATAWVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDQ5</accession>
    <name>F4FDQ5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_06470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.70" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06470"/>
    <dbReference type="EnsemblBacteria" id="AEB42418">
        <property type="protein sequence ID" value="AEB42418"/>
        <property type="gene ID" value="VAB18032_06470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06470"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021150_2_1_11"/>
    <dbReference type="OMA" id="KTRISGH"/>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="11">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PfkB" evidence="11">
        <location>
            <begin position="317"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="CTP_transf_like" evidence="12">
        <location>
            <begin position="444"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB42418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="628" mass="65078" checksum="78FBCA1F851A3E2D" modified="2011-06-28" version="1">MARAAAEQLRLAEVVQSWLGRPVLVLGDAMLDEWRFADSDRLCREAPAPVLTLRRRISAAGGAANTAVNIAALGGRSVLVAPVGADVAGDELHDCLDRAGVWDRTVSQPGRHTPVKRRMLAGDQILLREDSGDPDDPLSEDGVDRLLTALDCATRELQAAADGVAPTLVICDYGLGALPARVRAWLVAQRDRYATVALDAHDLADWRGLAPTVVTPSFAEATRLLARAGRGGGELQLEHPEVDAGDGPSELTVGAAPGGAGQRTGGPTGEPTPGEDRVAMTHDGLSVTGTGVTVNADAGAGVDRAVLAESRLAELRAHTGADVVAVTLDTDGAVVGGADGQPSRSHSTPVPASHAVGAGDAYLAAMTLALAADAPLSTAAHLAQLAATSTVTGTGTCVCRREDLLTALGQPALGGDDRQVLIGTEGLDTLVAEHRRAGRSVVFTNGCFDVLHRGHVRYLEQARALGDLLVVAVNSDGSVRRLKGPDRPVNPVEDRTALLAALSCVDHVVVFEEDSPTALIEAIRPDVYVKGGDYPPELVPEAPLVQRLGGQVRTLGYVPDRSTSAIIDRIRAYGQEGSPEVVAGGPPTRPDPDVDRVLDADRALGVTLPDPADEMTGSAAPPMTGKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE21</accession>
    <name>F4FE21_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733545.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18940"/>
    <dbReference type="EnsemblBacteria" id="AEB44890">
        <property type="protein sequence ID" value="AEB44890"/>
        <property type="gene ID" value="VAB18032_18940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18940"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_3_11"/>
    <dbReference type="OrthoDB" id="1694312at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="83"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="265" mass="28762" checksum="6962CED4D5B179C4" modified="2011-06-28" version="1">MKATLVAGLNRGARTVALALGLPVLLFTAWWVLSADSTTIFLPPLSRIVEAFGQVWFSEVFFRDVLPSLRRLAAGYAAALLVGVGVGYLVGRWSVVRDLTSPILAYFRVLPAPVLIPVLLVAVGIGDATKLIVIASGAVWPILLNTADGVRAVDEVQLDTAAAYRLRAWTRHGLILRAATPQVFAGARQALGISLIVMVVSEMLMSTDGLGFTVIRFQRTFAIPEMWSGVLLLGLLGFGLAKVFELIERRALRWHRGATGREESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEG5</accession>
    <name>F4FEG5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736042.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01615"/>
    <dbReference type="EnsemblBacteria" id="AEB47407">
        <property type="protein sequence ID" value="AEB47407"/>
        <property type="gene ID" value="VAB18032_01615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01615"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_7_2_11"/>
    <dbReference type="OMA" id="RSDNGNW"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="17506" checksum="7DE0088F43E8BD2D" modified="2011-06-28" version="1">MARIEHFNNPNAPRPNSIVVAVTVFVQDEQSRVLLIQRTDNGLWALPGGAQDFGEYIAETAVRETREETGIEVEVTGVVGIYTNPNHVVEYSDGEVRQQFSICFRGRYLNGEPKTSDESSSVEWVSRQELIGLPIHPSMRLRIDHGFELCSTPYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEH4</accession>
    <name>F4FEH4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736051.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01660"/>
    <dbReference type="EnsemblBacteria" id="AEB47416">
        <property type="protein sequence ID" value="AEB47416"/>
        <property type="gene ID" value="VAB18032_01660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01660"/>
    <dbReference type="HOGENOM" id="CLU_2703809_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="73" mass="8418" checksum="FE2215633E616ADD" modified="2011-06-28" version="1">MTPERLTLVLTLLGVTALLISLLCGLRAAAAVRAYYCGRRDQLTRRMDHQRFRNLDYLHGAVDQYLREQRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEK6</accession>
    <name>F4FEK6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736082.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01820"/>
    <dbReference type="EnsemblBacteria" id="AEB47448">
        <property type="protein sequence ID" value="AEB47448"/>
        <property type="gene ID" value="VAB18032_01820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01820"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_4_0_11"/>
    <dbReference type="OMA" id="RYRWVMA"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7576" checksum="7637B2B335549540" modified="2011-06-28" version="1">MAGSPSDGRLSDVKFLTVAEVATVMRVSKMTVYRLVHSGELAAVRVGRSFRVPEHAVHEYLRGAFQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEP1</accession>
    <name>F4FEP1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_06555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731108.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06555"/>
    <dbReference type="EnsemblBacteria" id="AEB42435">
        <property type="protein sequence ID" value="AEB42435"/>
        <property type="gene ID" value="VAB18032_06555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06555"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013420_0_0_11"/>
    <dbReference type="OMA" id="WGPPYGQ"/>
    <dbReference type="OrthoDB" id="1388804at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="4">
        <location>
            <begin position="528"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="824" mass="86433" checksum="A9B9E06C382EF04B" modified="2011-06-28" version="1">MSTSLADHLRALPDESLAALLQLRPDLVVPVPADVAALAIRAQSRVSVSRALDGLDQFTLQIMDAARLTRDPVDGTTSVDGVLALATTGPHPPAPTSVRAAIDRLRARFLVYGPDHQLQLVGGIDEISPYPAGLGRPAAELDARTAALCADPAKLRRTLLAAPPSARAILDRLAAGPPVGSVPPGALQAPATGSDDDLPPDETNGGAPTGSPVRWLVDHRLLVRVAGGKGGTSGMVELPREIGLLLRRDTGPLGPLSAGPPPVASTPREPKAVDSAGAGQTMEVVRHTEALLEQLAAEPAPVLRSGGIGVRDLRRLARVTGLDEPTAALLLEVAYAAGLAGEMELSASAGRYGADQQVLPTAGYELWRAGSLAQRWEQLARAWLTMTRQVGLIGQRDDRDRPITVFSAEAERAGAPAARRAVLGVLADLEPAAAPTVDEVLALLDWRAPRRSRGREAAHREVLAEAATLGVTGLGALTSYGRLLMAEATATEERDSDDPLGLRTESEDAGGTAVRVLDGLLPAPVDHFLVQADLTVVVPGPAEPALAAELDAVAEPESAGGASVYRVTSGSVRRALDAGYSAEDLHALFRRRSRTPIPQGLTYLVDDVARRHGGLRVGSAGAYLRSDDEALLTELLADRRVEELTLRRLAPTVLVTPYQSGRMLAVLREAGYAPVAEDATGTAVLTRAKARRAAARVSVATRAIDPLTTARLPLPRLLGVVEQIRRGDATARAARRAPAAVRGSAASTGPAPAHSHADALAVLQQAIRDKALVWVGYVDAHGATASRLVRPVSLGAGYLRAEDERTEMLHTFALHRITAAVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FET5</accession>
    <name>F4FET5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Csbd family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731152.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06775"/>
    <dbReference type="EnsemblBacteria" id="AEB42479">
        <property type="protein sequence ID" value="AEB42479"/>
        <property type="gene ID" value="VAB18032_06775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06775"/>
    <dbReference type="eggNOG" id="COG3237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135567_1_1_11"/>
    <dbReference type="OMA" id="NAKQMGD"/>
    <dbReference type="OrthoDB" id="2089955at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="57" mass="6212" checksum="5504E36FE7563BF1" modified="2011-06-28" version="1">MGVEDKFNNSAENTTGKVKEGVGRATDNEQLEAEGRADQTRANIKQAGEKIKDAFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF55</accession>
    <name>F4FF55_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CypC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19290"/>
    <dbReference type="EnsemblBacteria" id="AEB44960">
        <property type="protein sequence ID" value="AEB44960"/>
        <property type="gene ID" value="VAB18032_19290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19290"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037319_0_0_11"/>
    <dbReference type="OMA" id="GPRHWRA"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="46354" checksum="D87DA5ADFAF6D7A9" modified="2011-06-28" version="1">MLVDLMGRMDDTLTLAIQGYGWLPNRLRHSPQDVVRTRLLGQTTVALRGPDAARFFYDEQHIRRHGAIPEPLRGTLFGKGAVHTLDGEPHRVRKAMFTALLMNGGYDGLVERAETAWDAATRSWAGRQVVLFDETAPVLARAVCEWTGIPVQPQDLPALAADLVAMVDGFATAGPRHWRARRARGRRERWLADIVTQVRRGELDVPPGAALAAVAAHRDSDGELLDPQIAAVELLNIIRPTVAVTWFVTFAGHALHRWPEHRGRLRQGDAVFAEAFAHEVRRFYPFAPFIGGRARTDLTWRGTDIPAGAIVLLDLYGQNHDARLWPDPYRFDPDRFVGREIGAFDLVPQGGGDPRTGHRCPGEQITVALLKALAVRLARLDHQVPAQDLDIPLHRIPTRPVSGLVMAVPARSAAPLSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFL8</accession>
    <name>F4FFL8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-asparaginase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02055"/>
    <dbReference type="EnsemblBacteria" id="AEB47495">
        <property type="protein sequence ID" value="AEB47495"/>
        <property type="gene ID" value="VAB18032_02055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02055"/>
    <dbReference type="eggNOG" id="COG4448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062004_0_0_11"/>
    <dbReference type="OMA" id="DDCGAPT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="32135" checksum="C165DCF61335DEA6" modified="2011-06-28" version="1">MPLAEVVRSDFVEGVHRGSVVVLDVTGAVLDAAGDVSGPIFPRSANKPMQAVGMLRAGLPLTDPADLALVAASHAGEEFHLARVARLLADAGLDEEALHCPPDLPVGEQAREAVLRAGGGPTRIQMNCSGKHAGMLLTCRSAGWPVDGYWRPEHPLQQRLRDAIEDLTGEQAAAVGVDGCGAPVLAVSLTGLARAYLRLVSAETGTVERTVADAMRAYPEIVGGTEADDTRLMRGVPGLLAKVGAEGVIAAAVPGVGALALKIDDGAGRARMPVVTSALRRLAIDAPVLAEFAEIPLFGGGLPVGTIRPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFN2</accession>
    <name>F4FFN2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47509">
        <property type="protein sequence ID" value="AEB47509"/>
        <property type="gene ID" value="VAB18032_02125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02125"/>
    <dbReference type="HOGENOM" id="CLU_3190365_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="46" mass="4490" checksum="94259F8C9812B90F" modified="2011-06-28" version="1">MSANQDLPLTGASTAAVGLVGSILLGLGALLVTVANLGAKARRKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFP8</accession>
    <name>F4FFP8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02205"/>
    <dbReference type="EnsemblBacteria" id="AEB47525">
        <property type="protein sequence ID" value="AEB47525"/>
        <property type="gene ID" value="VAB18032_02205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02205"/>
    <dbReference type="eggNOG" id="ENOG503282K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186189_3_2_11"/>
    <dbReference type="OMA" id="FMAFRPE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="6009" checksum="CE0AEBB34D163691" modified="2011-06-28" version="1">MPVFVKKVLAWGSLAFLIYFMAFRPEGAAQMFKAIGGALVMMAQGFGDFLTSLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFW5</accession>
    <name>F4FFW5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07105"/>
    <dbReference type="EnsemblBacteria" id="AEB42545">
        <property type="protein sequence ID" value="AEB42545"/>
        <property type="gene ID" value="VAB18032_07105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07105"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_2_0_11"/>
    <dbReference type="OMA" id="FETTMGL"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="43749" checksum="005CDCBC1938D634" modified="2011-06-28" version="1">MTLPDAVARPRIAAVDLACSDDPYPEYERLRAQGPVVRGEFGQWLVVHHGAVSALLRDGRLASHFPREFIRLTLGHGPAAEFPTRIVLTQDPPEHTHARRFLGQAFGTPRVRAMTPAVAALVEELLAPARDAGRLDLVTDLAVPLPVTVICRLIGIPDADRDQVLPRVIELAQVFDAANLKPDERDGVDAAVGWLREYVTALLRDATPGDSTLAGMFAAATPEERGDVATIVDNLLFLFHAGFETTMGLVSNGCVALLRNPDQLDRLRRDPTLVRPAIDEFLRFDSPIQNAIRVAREPIEIGGHKIRTGRSVMLLLGAANRDPAVFDRPAELDLSRTPNPHLGFGGGLHHCLGTALARLMGELTFTALATGFRDIAPDGDALRRQHGSLRSFERLPLAVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFY4</accession>
    <name>F4FFY4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07200"/>
    <dbReference type="EnsemblBacteria" id="AEB42564">
        <property type="protein sequence ID" value="AEB42564"/>
        <property type="gene ID" value="VAB18032_07200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07200"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="OMA" id="FLEYFAV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="427"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="520" mass="56206" checksum="2DEBC25A77992922" modified="2011-06-28" version="1">MPSPHDPPALLAARITATPDAPALADEGGVLTWAHLGERVNRWRALLASTGVSSGDAVALMLGNRREALEALLACLHAGITVVPVNWHLTAPEVAYLLTDADTRLLVVDPPRAEVGAKAAADAGTVTALVTGDEVAYGLAAVEPLLAAIDPSAAPAEQECGQLMIYTSGTTGRPKGVLNGLFVTGAPWARATRLLEYATGTLGVPTDGRVLLVGPWYHSAQLFFALLPLLNGATLVVRERFDPAGMLSTMDAERITECHLVPTQFVRLLRLDPAVRAGFSGASLRRIWHGGGPCPPDVKRRMIEWWGPVLVEYYAATEGGVVTLIDSADWLTHPGSVGRAVPPNRILVVDDDGRELGPYQPGRIFIRRPGRGFRYHNAAEKTRAAHLAPGVFTYGEMGHLDDDGYLYLTGRAQNMIVSGGVNVYPAEIEQVLLQHPDVRDAVVLGVPDEEYGERVAAVVEWEPGGRQLPWSALDAHCRQHLAGFKVPRCWRSVDAIPREPTGKLRLDQLRTLCGDDRWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG58</accession>
    <name>F4FG58_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_13450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13450"/>
    <dbReference type="EnsemblBacteria" id="AEB43802">
        <property type="protein sequence ID" value="AEB43802"/>
        <property type="gene ID" value="VAB18032_13450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13450"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_11"/>
    <dbReference type="OMA" id="ITPACGE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="8">
        <location>
            <begin position="7"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="542" mass="56546" checksum="0B9D851DA6FFFC98" modified="2011-06-28" version="1">MNPGDTAWVLVCTGLVLFMTPGLAVFYGGMVRSRNVLAMLQQNMIALGVVSLTWVFVGYTIAFGDDAGSGLFGNLELFGLTDLKVPPAPHLHVVDARITIPALAFVAYQMMFAVITPALVTGATAGRLKFGGWVLFLAIWSIVVYAPIAHWLWHPGGWLAKLGTQDWAGGMVVHASAGAAVVAVLLVVGRRRNWPHAAAPPNSIPLTILGAGILWFGWFGFNGGDGLQANGVAAQAVLNTHLAAAAGMLVWLLVERFSDGHSTVVGGVSGAVAGLATVTPTAGYVNTLSAVAIGAIAGLVCHFALRLKYLLRLDDALDVLAVHFVGGMLGSLLLGLFGDNGINPLGRDGLFLGGGGGLLWDQLVGVVSVVAFSFVLTWLIAAGIQAVIGLRVPDKDQDRLDQAQQGTDAYHLGGVTSLAAPGGPQRRPRPGGAGAAPVPAGHPVKLVSALLDPSRVSDSGMLREELLGAGAISLTVSDTTAATEGTVRQVLPRGYWQEQPLLARLRLDVLVPAEAEQAVVDLLSRYEPRLVWASDVAPVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGG5</accession>
    <name>F4FGG5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NarL family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733758.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20005"/>
    <dbReference type="EnsemblBacteria" id="AEB45103">
        <property type="protein sequence ID" value="AEB45103"/>
        <property type="gene ID" value="VAB18032_20005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20005"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="RMDICEI"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="21952" checksum="AC2BBE7730D3A8E3" modified="2011-06-28" version="1">MIRVLVAEDQNLIRGALVALMSLESDITVVAETERGDTILAEIEQHRPDVAVVDIDLPGMDGIVAAQRLKDAGSPVRILVLTSVGTPGNFDRAMQAGVAGFLVKDAPSDRLCRAIRDVYAGRRVIDIELADSSSASAGPAERPRPGPLTQRERGILAALHDGMPVAALRSVFGLSSATLQAHVVAAVSKTGAPDPHEAARVAYHKGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGG7</accession>
    <name>F4FGG7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_26020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734953.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26020"/>
    <dbReference type="EnsemblBacteria" id="AEB46302">
        <property type="protein sequence ID" value="AEB46302"/>
        <property type="gene ID" value="VAB18032_26020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26020"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_11"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="334" mass="35396" checksum="2C8A221F164C8143" modified="2011-06-28" version="1">MTIRVGINGFGRIGRNFFRAVLASGADVEVVAVNDLTDNATLAHLVKYDSILGRLPHEVKATADEITVGGKTIKAYAERDPAALPWGDLNVDVVIESTGFFTDANKAKAHLDGGAKKVIISAPAKNEDVTVVMGVNEGSYDPAKHNIISNASCTTNCLAPMAKVLHDTFGIERGLMTTIHAYTQDQNLQDAPHSDLRRARAAALNIVPTSTGAAKAIGLVLPDLKGKLDGYALRVPIPTGSATDLTVTVGRETTVDEVNAALKAAAEGPLRGILSYNEDPIVSADIVTDPASCIFDAPLTKVIGNQVKVVGWYDNEWGYSNRLVDLVKLVGQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGL5</accession>
    <name>F4FGL5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_26260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735001.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26260"/>
    <dbReference type="EnsemblBacteria" id="AEB46350">
        <property type="protein sequence ID" value="AEB46350"/>
        <property type="gene ID" value="VAB18032_26260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26260"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_1_11"/>
    <dbReference type="OMA" id="VFWYKLQ"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="369" mass="40770" checksum="2F4E49B83424DBCC" modified="2011-06-28" version="1">MTSVREWIDSGRHAVSDRWHNAPRWMRWAVIAAVIVFFYALPNREFYQWLGPIPTTGSNFGQVLFTISIYVLLAVGLNIVVGFAGLLDLGYFGFFAVGAYTVAVLTSPSSDLKTLWPWLLALPVALVLTMISGVMLGTPTLRLRGDYLAIVTLGFAEMIRVAATSSEFLKGQRGFNQIPHPPGSYSDGKPIFGVLDPRPYYWLVLTLIILVVIGVRNLNRSRVGRAWISIREDEDAAQLMGVPTFKFKLWAFASGAFIGGLAGALFAGKQNFVSSQNLELLNSIIILAAVILGGSGNIVGAIVGGGLVAYMIERFRGIEFFGVELYEYRFMFFGLVLVVMMIFRPQGLIPNRRRAAEFKDRRKEVIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGN2</accession>
    <name>F4FGN2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase class 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735018.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26345"/>
    <dbReference type="EnsemblBacteria" id="AEB46367">
        <property type="protein sequence ID" value="AEB46367"/>
        <property type="gene ID" value="VAB18032_26345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26345"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029537_1_2_11"/>
    <dbReference type="OMA" id="QQMTIGS"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307892" evidence="1">
        <location>
            <begin position="26"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="28613" checksum="F827CEBCD3E9C38B" modified="2011-06-28" version="1">MLLRKAVPVLALTLAAVLSAPPASAAVTSAAAVAAEAPASTAAVTTAADASVASAAGDGLGALANANPVIVVGGLSGIAAVYQPLAARLRADGYRVWVYELPNLGLGDIAASAGSLRTFVGTVRSSTGAAKIDLVAHSEGGLVSRYYIKNLGGGDTIGRYVSLGTPQYGTYVANMLAFLGLGSCAGIVACQQMTIGSSFLAALNAGDDTPGSVRWTTVRTWQDELVRPVDNATLADGATNVLIQAKCPLRVVGHLALVVDGTTYSIIRQALRDHPINPSCLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGS9</accession>
    <name>F4FGS9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_02525</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736222.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02525"/>
    <dbReference type="EnsemblBacteria" id="AEB47589">
        <property type="protein sequence ID" value="AEB47589"/>
        <property type="gene ID" value="VAB18032_02525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02525"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026758_0_0_11"/>
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    <dbReference type="OrthoDB" id="1627779at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="50"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="336"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="553" mass="60232" checksum="ADD0D17DBEAB8BDF" modified="2011-06-28" version="1">MSTEFSYAPLLPTGPDQTEYRLVTDEGVDVVNGPGGRRFLTVDPAALTALTAEAMHDIAHFLRPAHLAQLRSIIDDPAASPNDRFVALDLLRNANIAAGGVLPMCQDTGTAIVMGKRGRHVLTDGSDAEAISRGVWQAYTRLNLRYSQLAPLTMWEERNTGSNLPAQVELYAEDPDGHPDAYKFLFMAKGGGSANKSYLYQETKALLNPTRMMQFLEEKLRLIGTSACPPYHLAVVIGGTSAEYALKTAKYASAKYLDALPTSGSMTAHGFRDLELEAEVLELTRNFGIGAQFGGRYFCHDVRVVRLPRHGASCPVAIAVSCSADRQAVAKITPSGVWLERLETDPARYLPEVTDAQLDTTEVVRVDLNRPMDEIRAELSKYPVKTRLSLTGPLVVARDIAHAKIAERLDAGEPMPQYLRDHAVYYAGPAKTPEGYASGSFGPTTAGRMDAYVEKFQAAGGSMVMLAKGNRSAQVTRSCEQHGGFYLGSIGGPAARLAQDCIKHVEVLEYAELGMEAVWKIEVEDFPAFIVVDDKGNDFFAEVTKPVLTIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH21</accession>
    <name>F4FH21_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731308.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07575"/>
    <dbReference type="EnsemblBacteria" id="AEB42635">
        <property type="protein sequence ID" value="AEB42635"/>
        <property type="gene ID" value="VAB18032_07575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07575"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_16_11"/>
    <dbReference type="OMA" id="HGRRNTH"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="66"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="22509" checksum="1B32C18CE02B857E" modified="2011-06-28" version="1">MSPILSSIVTAVGGVLAGLALAAGLLWHQQQALTRARHAADHDDTTGLPNRRALLAAADRAAQRGTPFGLVLIDLDGFKAINDTFGHEAGNDVLTDIGRRLAALPGPVWLAARLSGDEFALLVDGGPDEVAAAARAAWRTVGRHPVDLGAHTVAVRASVGHTTAALGVSPRTLLHHADMAMYQAKQSGAGVYGTTTTTAHTGVPPGTRLRDLRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH99</accession>
    <name>F4FH99_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732544.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13825"/>
    <dbReference type="EnsemblBacteria" id="AEB43877">
        <property type="protein sequence ID" value="AEB43877"/>
        <property type="gene ID" value="VAB18032_13825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13825"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123613_0_0_11"/>
    <dbReference type="OMA" id="HNAHVEN"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="25665" checksum="DADACC5E28FA0806" modified="2011-06-28" version="1">MITESGERGSAPVLLLLHGMGATGDGWLPCAPLLHQRWPGRWMAPDLAGHGASPPLPAYSFAALADQVAASLHPGDRVIVLGHSLGGVVGLALAAVSRAVTVDAVVGLGIKAVWSPAELSRATDLAARPVTWFDSRDEAARRYLRVAGLADLLSPEDPAVAAGLRQENGRWRLAMDPSAFAVGEPNLGALLATIDAPVLLARGEHDPMVTDAQLKEYGVPVVTLPGLGHNAHVEDPAAVLALLDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHD1</accession>
    <name>F4FHD1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_13985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13985"/>
    <dbReference type="EnsemblBacteria" id="AEB43909">
        <property type="protein sequence ID" value="AEB43909"/>
        <property type="gene ID" value="VAB18032_13985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13985"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_11"/>
    <dbReference type="OMA" id="IELANTH"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="240"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="167"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="357" mass="38272" checksum="310622B9A653844D" modified="2011-06-28" version="1">MGADLSYVEAAVTGLSQNLTRKALIVGKSTVPVGTVEWVEQLVSKNAPADLGIEVAWSPEFLQEGFAVDDVLRPNRIVIGVKTEWAKDMLHATHKGVLDLAAAEGRTVPLMVTDFATAELVKVAANAFLATKISFINAMAEVCEVAGGDVVQLAQAIGYDPRIGNRFLQAGVGFGGGCLPKDIRAFQARAQELGVGDALRFLHEVDLINLRCRPRVMRLAAELLGRSGPAGPDLSGTRIAVLGATFKPNSDDVRDAPALAVAALLAKSGSDVRVYDPQGMENARVVQPKLTYAPTLNDAVRSADLVCVLTEWAEFRESDPYVLGTLVASRRVVDGRNCLDSARWMKAGWQYRGMGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHD3</accession>
    <name>F4FHD3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733760.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20015"/>
    <dbReference type="EnsemblBacteria" id="AEB45105">
        <property type="protein sequence ID" value="AEB45105"/>
        <property type="gene ID" value="VAB18032_20015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20015"/>
    <dbReference type="HOGENOM" id="CLU_2439965_0_0_11"/>
    <dbReference type="OrthoDB" id="2089495at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036648">
        <property type="entry name" value="CN_Hdrase_a/SCN_Hdrase_g_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027615">
        <property type="entry name" value="TOMM_nitrile_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56209">
        <property type="entry name" value="SSF56209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04351">
        <property type="entry name" value="TOMM_nitrile_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="90" mass="9111" checksum="32127506626DFAB8" modified="2011-06-28" version="1">MASVPAEHRTRFARLVADAWSDPTLANRYQLDPAAVLAEYGIVLGAGDEIPDLPPAPGEIAVEDLSTTAGAAMATIGTVSCPGACVGMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHR6</accession>
    <name>F4FHR6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mraY</name>
        <name evidence="8" type="ordered locus">VAB18032_26811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735086.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26811"/>
    <dbReference type="EnsemblBacteria" id="AEB46435">
        <property type="protein sequence ID" value="AEB46435"/>
        <property type="gene ID" value="VAB18032_26811"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26811"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_0_11"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="377" mass="39857" checksum="0D189154A8532DF7" modified="2011-06-28" version="1">MRAVIVAIGVAFLVSLFCTPIAIRVFTRLKAGQPIRAEGPQMHQGKKGTPTMGGVVFILATVIAYVAGHLALTTLPDAQIAQVEPTITALVLLGLMVFAGAVGFIDDFLKVRKRHSGGLSARGKLLGQILVGAVFGVVALYFPSTMTDATGAQTNTETVGSTTLSFIRDIPALDVTKIGAVIIFIFVVMAATNGVNLTDGLDGLATGASVMVLGAYAVIAFWQYRHWCADPAYTANPNNYCYTVRDPLEIALIAGAAAGACVGFLWWNTSPARIFMGDTGALGLGGLIAGMAMSTRTILLLPIIGGLFVIITMSVVIQIISFKTTGKRVFRMSPLQHHFELAGWSEVNIVVRFWIIAGIGVAIALGLFYSDFLANMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI17</accession>
    <name>F4FI17_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736342.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03130"/>
    <dbReference type="EnsemblBacteria" id="AEB47710">
        <property type="protein sequence ID" value="AEB47710"/>
        <property type="gene ID" value="VAB18032_03130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03130"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_6_0_11"/>
    <dbReference type="OMA" id="TWARERF"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="111"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="417" mass="44275" checksum="FF6E33F00C7AA7AD" modified="2011-06-28" version="1">MGKYRVAVIGGMPAPIHGAKELGIDVVLVHEEGKYEQSILQHTERVVHAPLADGPAIHAALSPLHAERPFDRVMTTTEVAAISSGYVVDQFGLPGVTEFTARALKDKALTRECLAKAGVENVRYQVVSSVDEAVAFLAQVGGKIVLKPLDGAASLHIKEVETPAQVAEAMAELAAAGITNPMAEEFLSGPVVSVDSFSFEGRHLTIGYSEYRMNDRFVEWEVSTPSRVAVPYLAELRELTAKLLDAVGVTEGPSHSEFVLTPDGPRVLESHARLAGSGAPELVRRAFGLDLNRMFLTVPLGIDELPLESPAPIGGAVALFLTPDPGPIKSITVHEDIPAKVLRIPPGEQAKVFMPYLFELGAEDTAVVITKNPGDEVAPLLTVADCSNGYILASGTDALDAIAKAEAINAQIEFAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI48</accession>
    <name>F4FI48_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
            <plasmid evidence="1 2">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713134.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB48012">
        <property type="protein sequence ID" value="AEB48012"/>
        <property type="gene ID" value="VAB18032_30244"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30244"/>
    <dbReference type="eggNOG" id="ENOG5032P53">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943159_0_0_11"/>
    <dbReference type="OMA" id="WISPRIG"/>
    <dbReference type="OrthoDB" id="1843936at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB48012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="32811" checksum="8F5F6CDE1BB8F659" modified="2011-06-28" version="1">MNSDELKFQRDPRQLETAREAARHAGAAGAAVRWRFIARTDLTEQPPPMARILRGGGGRGGATRLKLFLSLLWLARGRPDPVFGYPAQQLASLLGLSSPSAAGARRIHQALKWLHDENFLALEHRPGEAARIHMLDDAGSGAAYQAPGPLVSRKRKHSTDREKHFYVQLKRELWTEGWISHLSGAAIAMYLAALHEERGKTGEAVWISPRIGRERYDLSDETRGKGFAELVNMGLLNLAKRPVPQTSFDERYRARNVYRVVPNGLARVHGKSRDVLTSGDSLDPFAATEDVSSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F145</accession>
    <name>F4F145_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_07905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731372.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07905"/>
    <dbReference type="EnsemblBacteria" id="AEB42699">
        <property type="protein sequence ID" value="AEB42699"/>
        <property type="gene ID" value="VAB18032_07905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07905"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="ATMLKPN"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="24433" checksum="4203A058FE1CBDC3" modified="2011-06-28" version="1">MTGDVIVLDQVGRRYAGGVVALADVSLRIGHGELVAIVGPSGSGKSTMLNVIGTLDRPTSGTVLIDGHDVARLSDRQLSALRATRIGFVFQQFHLAPGVPVLDNVADGLLYAGVPRRERRRRAEAALHRVGLGHRLGHRPHELSGGERQRVAVARAVVGEPAVLLADEPTGNLDTSSGTAVLDLLHGLHRAGTTVVVITHDREIAAGLPRQVQMRDGRLRADSRPVPSGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1B7</accession>
    <name>F4F1B7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732620.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14205"/>
    <dbReference type="EnsemblBacteria" id="AEB43953">
        <property type="protein sequence ID" value="AEB43953"/>
        <property type="gene ID" value="VAB18032_14205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14205"/>
    <dbReference type="eggNOG" id="ENOG502Z954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033907_1_1_11"/>
    <dbReference type="OMA" id="WSGPRNL"/>
    <dbReference type="OrthoDB" id="1555988at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="27527" checksum="FC61C571885DB3ED" modified="2011-06-28" version="1">MSGTPVIALWAVPRSRSTAFLRMLIERGDLAVVHEPFSNLAAVGHFDIDGERAASIGELFDLLLALGRRSGQRVFLKETTDYPYDEILRDRRLYTDVTNTFMIRDPAAVVASHYAMNQSVERDEIGFERLHGMVEAVRAVTGEVPLVLDGDEVAAIPEAATERFCQVTGLPYRPEALRWQPGEQQAFARTRAWHRDVEASSGFTTRTTRHEVRPDNDPWLAALEAYHRPFYQALHALRFSPHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Y2</accession>
    <name>F4F1Y2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03225"/>
    <dbReference type="EnsemblBacteria" id="AEB47729">
        <property type="protein sequence ID" value="AEB47729"/>
        <property type="gene ID" value="VAB18032_03225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03225"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_0_11"/>
    <dbReference type="OMA" id="YIAYNVM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="32"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="505" mass="55648" checksum="5BA125C761BC07C4" modified="2011-06-28" version="1">MLDPSLASDGESLRVARQVFETLVRPEDGGTKVSPGLAESWEPDAAGTTWTFKLRSGVKFHDGEEFNAEAVCYNFNRWYNAKGLMQSPDVTAYWQDIMGGYAANEDPALGESLFKSCTATDPTTVSLAFTRVSSKIPAALMLPSFSIHSPKALEQYDASNISGSADDIKYPAYATAHPTGTGPFKFKAWDVPNKTLTLERNEDYWGEKAKLKTLIFKTISDENARKQELRSGGIQGYDLVGPADVEPLKGEGFNVLTRPAFNILYLAINQKGNPKLADLKVRQALAHAINRQALVDSKLPPGAQVAVNFFPDTVEGWNGDVTKYEYDAEKAKALLAEAGASDLTLRFHYPTEVTRPYMPNPKDLFELISADLQAVGIKIEAIPLKWSPDYLNATTSGDKHDIHFLGWTGDYGDGYNFIGTFFDRQKDEWGFNNPALFEKFKKADSTADMAERVALYKELNADIMNFLPGVPISHSPPAIVFGKDVTGVKASPLTDERFSTAEFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F224</accession>
    <name>F4F224_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03435"/>
    <dbReference type="EnsemblBacteria" id="AEB47771">
        <property type="protein sequence ID" value="AEB47771"/>
        <property type="gene ID" value="VAB18032_03435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03435"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020410_0_0_11"/>
    <dbReference type="OMA" id="VPIYLMR"/>
    <dbReference type="OrthoDB" id="870586at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="674" mass="72101" checksum="1933CBAAD9DDA6DD" modified="2011-06-28" version="1">MSTAPGRPGGRLSGDRIATAALVMIAVSVLWRAQVASRGFLAADDYVLITQAAESRLTVEHLFALYNNHLMPGGRLLIWLVTEYVGLAYWPYVLLMAIGQAILGITFFRLLRRMLRPSALLLLPLGLLLFSPLTLEASTWWAVGVNMLPMQIAMVLAVSAQVGYVQTGRRRHLVSLASALLLGLFFFEKSILIVPLVFLLTAACYADGGPVRAIWTTIRRWWPSWLMLTVLSLGFAAAYLGRSESSLRRPESVGEVFSFLTQMFGSTVMPGLVGGPWQWLGAGDGAPVASPPQLGTWVGWTIVAAVVAATVRQRRRAGRAWLLLAAYLLMVAGMLAATRLGSAFSGVAGGVPRYVSDVVVVAAICLGVAVVGLARRTDLTVPTTPAQPVIASTTPAVAATGQPARLVSGHGVIHAEAPVDPEPHPGRAAPGPPPADVPPSNPTEPPTPGLLGPVPERYREAVTVVLVLLLVAVGLGTVWTTARYGDEWAAKSGRSYIDTVRIEMASAPPDTVFFDAPVPDNVVPRLSSPYNLQSRFFRAFGTRPTFVDETDNASVLDDLGRIQVATIVGSIIQPGPQEGCGYRVGTGETVRMPLNEPRFEWHWVVRIGYLSSADGTATLRLGDGVAQFPIRKGLNQRFFRITGGGDTVELTVTSGEVSLCTNEIAIGDPAPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2F0</accession>
    <name>F4F2F0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14550"/>
    <dbReference type="EnsemblBacteria" id="AEB44022">
        <property type="protein sequence ID" value="AEB44022"/>
        <property type="gene ID" value="VAB18032_14550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14550"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057862_0_0_11"/>
    <dbReference type="OMA" id="HVADEQV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="236" mass="26766" checksum="D695BD46C6BF6C14" modified="2011-06-28" version="1">MEYLTRLEQGRDSRPSPEILAALADALRLDDADRRHLQQLASVDHHRHLCAGERPSVSHTVRPTVRTLLEALRDRPAYLLNRLADVLAWNEPFDRLARPLGLLDGEHPNLVWYVLADERAREHFPDWADLADQQMADLHRLREGDPATDALAERLDRTVGEPFRSRWQRRPVATHSSGVRRLRHPEVGPLRLAYETLEVAGDQQRLVVAQPADADSAAALDRLLGRRPDSLRSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2L3</accession>
    <name>F4F2L3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenocysteine synthase</fullName>
            <shortName evidence="5">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">selA</name>
        <name evidence="8" type="ordered locus">VAB18032_20890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SelA family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733932.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20890"/>
    <dbReference type="EnsemblBacteria" id="AEB45278">
        <property type="protein sequence ID" value="AEB45278"/>
        <property type="gene ID" value="VAB18032_20890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20890"/>
    <dbReference type="eggNOG" id="COG1921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038142_0_0_11"/>
    <dbReference type="OMA" id="GATNRTH"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025862">
        <property type="entry name" value="SelA_trans_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12390">
        <property type="entry name" value="Se-cys_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Se-cys_synth_N" evidence="7">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="434" mass="44745" checksum="C397823F94D77C40" modified="2011-06-28" version="1">MGDGCADPRRRVPRTDALLAEPRLAAAVVGLGRDRVKAAVRQAQDRARRGEIDPDQVRDAALAALPPAAPRAVLNATGVVLHTNLGRAALSDAAVTAMVAAAGHTDVELDLQTGRRARRGRDALDALAAAVPQAEAVHVVNNGAAALVLAATVLAAGAEIVVSRGELVEIGDGFRLPDLIVSTGARLREVGTTNRSTLADYADAIGPDTGFVLKVHPSNFQVSGFTSAVPVRRLADLGVPVVVDIGSGLLAPDALLPDEPDAASTLTAGAALVTASGDKLLGGPQAGLLLGRAELVDRLRRHPLARALRVDKLTLAALAATLGDPATPTRTALHTDPASLRERTERLREAIAADGHKVEVVPSVAVVGGGGAPGVELDSWALSLPEHYARPLRTGEPPVLGRVTHGRLLLDLRCVPPHADDTVRAAVLAVPGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2P3</accession>
    <name>F4F2P3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lycopene beta and epsilon cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21040"/>
    <dbReference type="EnsemblBacteria" id="AEB45308">
        <property type="protein sequence ID" value="AEB45308"/>
        <property type="gene ID" value="VAB18032_21040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21040"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042644_0_0_11"/>
    <dbReference type="OMA" id="LQHFRGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="409" mass="44254" checksum="B96AA4EC7A5B67E5" modified="2011-06-28" version="1">MGSVPLEVDLALLGGGGAASLVLAALARHGVRDLRIAVVDPVHRRGQDRTWAFWDRPGNDLDELLSASWSRVEVVTAERQRVLDVAPLRYAMLRSSPIYDRAAEAERLLGVTRVVASADTVTDHGDGVLVGGTDGPALRAGWVLDSRPRPPERPGRTNWLQHFRGWWLAADRPLFDPTRAVLMDFRTPQPTRGVSFGYVLPVSSRYALVEYTEFSPHLLTGAAYDRALGGYCDLLGLDPARFTVGEVENGVIPMTDGPFVARPSPRVVRLGTAGGATRPSTGFTFAAMYRQADQVARALAAGGPPVPGPAYPPRHRWMDAVALRALDRDLVDGPAFFARLFDRNPASRVLRFLDGATTVAEDLAVMNSTRLVPMAAAAVGDAAGRLRDRVVPSRRPAWRVPPPVVGSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2T3</accession>
    <name>F4F2T3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735194.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27356"/>
    <dbReference type="EnsemblBacteria" id="AEB46544">
        <property type="protein sequence ID" value="AEB46544"/>
        <property type="gene ID" value="VAB18032_27356"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27356"/>
    <dbReference type="eggNOG" id="ENOG50324NU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2792880_0_0_11"/>
    <dbReference type="OMA" id="EGAIDMD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="68" mass="7570" checksum="0F13E1BCFC5F1B36" modified="2011-06-28" version="1">MTKPIPKMDTAELRDIAVRGGIEGAREMDREALIDALVARPGEGAWQEDTKPADVNPNDYFYQPPGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F307</accession>
    <name>F4F307_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735268.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27726"/>
    <dbReference type="EnsemblBacteria" id="AEB46618">
        <property type="protein sequence ID" value="AEB46618"/>
        <property type="gene ID" value="VAB18032_27726"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27726"/>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_0_11"/>
    <dbReference type="OMA" id="WQHRHGS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="134" mass="14269" checksum="949366E098E69F76" modified="2011-06-28" version="1">MRSEVITVRTGSRPTVQDITAEAESFVSGQGDGLLHVFVPHATAGVAIIETGAGSDDDLLTALDSVLPTDNRWRHRHGSPGHGRDHVLPAFVAPYATLPVLGGRLALGTWQSICLVDTNGDNTTRQVRFSFLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F319</accession>
    <name>F4F319_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736430.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03580"/>
    <dbReference type="EnsemblBacteria" id="AEB47798">
        <property type="protein sequence ID" value="AEB47798"/>
        <property type="gene ID" value="VAB18032_03580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03580"/>
    <dbReference type="eggNOG" id="COG1785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352234_0_0_11"/>
    <dbReference type="OMA" id="SADHIGW"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313549" evidence="1">
        <location>
            <begin position="32"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="210" mass="21457" checksum="EBE54721A4CF2648" modified="2011-06-28" version="1">MHRRNHRRLFAAAAASAVLAGSVALGTPASAEPVDSSDVRVTVDIEEIREPGVLAMTVAADSVALAEDGSTLLVRQFVGTLPTVTVTDTRTADEVPEGAAWAVLGSATDFVGGAGQAPIGAGHLGWKPKLIDGGDSGLVSEGEEVVTVLDEPTQPGNNVGLVDQELLVSTFDSGAVAGGEYTVNANLFLRTPADVAAGKYTSTLTLSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F350</accession>
    <name>F4F350_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03735"/>
    <dbReference type="EnsemblBacteria" id="AEB47829">
        <property type="protein sequence ID" value="AEB47829"/>
        <property type="gene ID" value="VAB18032_03735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03735"/>
    <dbReference type="eggNOG" id="COG4114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1068804_0_0_11"/>
    <dbReference type="OMA" id="RYAWPAC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="27726" checksum="DC4C3BD37999FA19" modified="2011-06-28" version="1">MEQVTAVLPAHAASSTALDPVTATLRAMFGTDVLPGLAPGLLVVDEADWAPAATLADGGRLPELLGSAARLWGGSPHASAALAWKAYSYWAALPVVLGWAVARRVPLLDADSTLIHFADPHTLITLGLRQSARVAVLPADPLVVTEPQRVQVVADEQELLATLRAALLEAHLSPLITAIQGEVRIGTRTLLGSVASGIAHGLLTASDSVPGSTVDAIDTLLDTLGLADLVELVPDADGKPTVQRRTCCLAFTLPKPKVCQGCCLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3D1</accession>
    <name>F4F3D1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator PadR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731526.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08685"/>
    <dbReference type="EnsemblBacteria" id="AEB42855">
        <property type="protein sequence ID" value="AEB42855"/>
        <property type="gene ID" value="VAB18032_08685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08685"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_3_11"/>
    <dbReference type="OMA" id="KDLIRGH"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12332" checksum="1E6AA166DBB0AB98" modified="2011-06-28" version="1">MNAQALHGHLDSLLLAVLERGALHGYAIIEALRARSDGRLDLPTGTVYPALRRLERAGHVASVWSTVNGRERRTYELTDAGRRTLAEQRAGWREFTATVGRVLDADPPSATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3F4</accession>
    <name>F4F3F4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731549.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08800"/>
    <dbReference type="EnsemblBacteria" id="AEB42878">
        <property type="protein sequence ID" value="AEB42878"/>
        <property type="gene ID" value="VAB18032_08800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08800"/>
    <dbReference type="eggNOG" id="ENOG5033ZY1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093862_0_0_11"/>
    <dbReference type="OMA" id="AYVHRYA"/>
    <dbReference type="OrthoDB" id="2077326at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="224" mass="23015" checksum="6B34CDE767115791" modified="2011-06-28" version="1">MPGIRNNGALALGGIALAALLGVIGHLGVRDLDPVSLTVSDYAVSESGGVIHLAMLTLGVASALLVPALGRLAGPGVRAGRLGAARLLLAMWAGGLLLAGLVPTNPPGTEMGTAAYVHRYASVVAFLALPVVGWLLAAHLPTGARTRHWLRVLAVASLLLAAAQIWSAYPGDRAFYGLIERVLILSEVTLLALLAVALPAHSHARTGRREVTPVRAASVAGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3F7</accession>
    <name>F4F3F7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_08815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731552.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08815"/>
    <dbReference type="EnsemblBacteria" id="AEB42881">
        <property type="protein sequence ID" value="AEB42881"/>
        <property type="gene ID" value="VAB18032_08815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08815"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="MSVMMAT"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="577" mass="62630" checksum="3BEF580CCD39384F" modified="2011-06-28" version="1">MLIRLLLANLRPYRRPLAVVVLLQFVSTMASLSLPSLNADIIDLGVARGDTDYILRTGGWMLALTVVHIVCLIAAVYLGARIAMGFGRDLRATLFGHVNRFSAREVARFGAPSLITRNTNDVQQVQMLVLMSCTMLVSAPIMSIGGVVMALREDVGLSWLMLVCVPVLAIVLGLIIRRMVPSFRLMQTRIDTINRVLREQITGIRVVRAFVREPYETRRFATANADLTATALRTGRLMALIFPVVMLVLNVSSVAVLWFGGQRVDEGAIQVGALTAFLQYLMQILMAVMMATFMLMMVPRAAVCAERITEVLDTDSSVVPAPDPVVEVAGRAELELRDVRFQYPGAAEPVLRDISFRVTPGSTTAIIGSTGAGKSTLLSLIPRLVDVTAGAVLVDGVDVRQLAPEQLWNRIGLVPQRPYLFTGTVASNLRYGNPDATDEELWTALEIAQARDFVEAMPEGLAAPIAQGGTNVSGGQRQRLAIARALVRRPEIYLFDDSFSALDLGTDARLRAALRPVTADAAVVIVAQRVSTIIDADQIIVLEDGGVVGMGRHEELLTSCPTYAEIVASQRTTEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3I5</accession>
    <name>F4F3I5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732760.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14905"/>
    <dbReference type="EnsemblBacteria" id="AEB44093">
        <property type="protein sequence ID" value="AEB44093"/>
        <property type="gene ID" value="VAB18032_14905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14905"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017703_1_2_11"/>
    <dbReference type="OMA" id="RCLHDSK"/>
    <dbReference type="OrthoDB" id="1555988at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="PTHR10605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="2">
        <location>
            <begin position="38"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="35276" checksum="78848D3620C529EB" modified="2011-06-28" version="1">MASIRDRVKQLVPTQVTSRVRESLVDYGVRTSDRRPLPDFLIIGTKRGGTTSLWNYLIQHPLVPRLFPAWNTKSSHYFEENWGRGEAWYRSHFPTQRQRETLENRHGGPVRVGEAAPLYMFHPLAAQRVAALMPQVKLIVLLRDPVERAYSHWKERRTNGVEPLDFAAALAAEPERTAGERERLIAEPEYFSEAYDWYTYRARGRYLEHLEPWLTHFDRAQLLFLPSEDLYRDARATYRRTLDFLGLPAHDLPDFKVYNDRRSAPLEPALRAELTQYYRPYNEALRQRLGLRLDWPDQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3M2</accession>
    <name>F4F3M2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_15090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732795.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15090"/>
    <dbReference type="EnsemblBacteria" id="AEB44130">
        <property type="protein sequence ID" value="AEB44130"/>
        <property type="gene ID" value="VAB18032_15090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15090"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_7_11"/>
    <dbReference type="OMA" id="RMANPLT"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="159"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="36095" checksum="04B6FFBFC95E1AB5" modified="2011-06-28" version="1">MEAAGDRRDVILVVDDDEDIARFVEFNLRLHGFDVMLASDGQEALELIERQRPDLAVVDLMMPRIDGLELTRRLRADPMTAVLPVIMLTAKGMTQDKVNGLSAGADDYLVKPFDTLELLARVTSTLRRNKEFREVSPLTGLPGNSRIRREIADRVRSGTDYAVGYIDIDRFKSVNDRYGFVRGDDFIAALARTLHQAVVSVAPPPAFLGHVGGDDFVFVCTPDQVLALTSRVSADFEKAADALYDPTDRERGYVELKDRRGNMRKAALVTLSIGVCVSDADKRLTSPLEAMTIASEMKSVAKSQPGSYVAVDRRRGVSDPNQRHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F466</accession>
    <name>F4F466_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_03985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736511.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03985"/>
    <dbReference type="EnsemblBacteria" id="AEB47879">
        <property type="protein sequence ID" value="AEB47879"/>
        <property type="gene ID" value="VAB18032_03985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03985"/>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_8_1_11"/>
    <dbReference type="OMA" id="HVVVRFY"/>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="546" mass="56333" checksum="57FC27BB6F8E93D9" modified="2011-06-28" version="1">MTNDLVVPAIVAVTLATLGIGFYGLRLARTTSDFLVASRVVSPTWNAAAIGGEYLSAASFLGVAGLILKYGVDVLWYPVGFAAGYLALLLFVAAPLRRSGAFTLPDFCELRLGSRRLRTLATVFVIFIGWLYLVPQLQGAGLTLATLAGSPYPVGALVVAVVVTANVALGGMRAVTFVQAFQYWLKLTALAVPAIFLALQWQADGRPAVTPPDGPTFRTATTVVVEHRAVLTLPDGQSRQVNPGDELTFAAGEPVPEVSGVATSATDWLLPSTAGSDDRGLFATYSLILATFLGTMGLPHVLVRFYTNPDGTAARRTTLVVLALVGVFYLLPTIYGVLGRIYTPQLLVSGQTDAVVVLLPEAALGAGTTGRLLAALVAAGAFAAFLSTSSGLLTSVAGVISTDVLGRGSVRGFRLATVIAGGVPLILALNVSGLDVSQVVGLAFAVAASSFCPLLVLGIWWRGLTDAGAAAGILVGGGAAVSAVLITVLGPPLSGWPATLTAQPAAWTVPLAFTVMVAVSLATRGRTPADTGRTMLRLHAPDSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F471</accession>
    <name>F4F471_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736516.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04010"/>
    <dbReference type="EnsemblBacteria" id="AEB47884">
        <property type="protein sequence ID" value="AEB47884"/>
        <property type="gene ID" value="VAB18032_04010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04010"/>
    <dbReference type="eggNOG" id="COG3162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123372_1_0_11"/>
    <dbReference type="OMA" id="HRSFVFP"/>
    <dbReference type="OrthoDB" id="1906817at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="13204" checksum="0278C0BB7AF7C6EF" modified="2011-06-28" version="1">MSTDTPATAPTDSEPERYLAVQRSDEFAGLRRALRGFVFPMTIAFFLWYALYVILSAYARDFMGTRLFGSNINVALVFGLLQFVSTFLIAWLYSRYADRKIDPVADKIRGELTGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4D0</accession>
    <name>F4F4D0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_08850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731559.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08850"/>
    <dbReference type="EnsemblBacteria" id="AEB42888">
        <property type="protein sequence ID" value="AEB42888"/>
        <property type="gene ID" value="VAB18032_08850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08850"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_11"/>
    <dbReference type="OMA" id="LHQRERF"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="7"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="27445" checksum="AF5B42F7CBD4A5B9" modified="2011-06-28" version="1">MKLARDTWLIFQRQLHLLLRNPVWVFVGVFQPVMYLLLFAPLLKPALNAPTQAEAYKIFVPGLLVLLAIFGGLFQGFGLIAELRAGVIERSRVTPVSRLALLLGRSLRDVVSLLVQAVIITLLALLFDLRVFIGDLLLAYLMLALIALMTSAVSYGVALKVKSEDALAPLMNTVAQPVLLLSGILLPLAFAPGWLQGIAKWNPFSWAVDGTRALFSGDIGNDKVWQGLTIIAILAAAGVYWAARQFARSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4I1</accession>
    <name>F4F4I1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rok family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731610.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09105"/>
    <dbReference type="EnsemblBacteria" id="AEB42939">
        <property type="protein sequence ID" value="AEB42939"/>
        <property type="gene ID" value="VAB18032_09105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09105"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="OMA" id="WSENAVA"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="382" mass="39831" checksum="56BBEE041A85182E" modified="2011-06-28" version="1">MSDRASTSPVSRERSREIKRLSVILAARQARLLSRVDLAEMTGLPAATVTALVRELIAEGYLIERGPGAPTTGRPREMLKFNPRAELVAAVSLEPPRISCEIADSEGAIIAHRTARFGGDVVETVCTFVLDLVGDNLPSLRGVAIAVPGVSTNGAVRLAPSVGLVEAWPIGESVQQRLGVPVVVDNDVNLMAAGECVAGAGADVANLLLIHVADGIGAGLVLDGKVRRGASGAAGEVGFMPLDAAPARSYSGVGEFEARWSVNAITERLVALHPGRRPESPVRELIQLAATSKPAREYLDEVLDAWARLILSCVCVIDPGMVLLSGAAAELDDAALEQIQSLLAAKTPAPTEVRRATLGDQAVLHGAISYALSAAVPLPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5U9</accession>
    <name>F4F5U9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22040"/>
    <dbReference type="EnsemblBacteria" id="AEB45508">
        <property type="protein sequence ID" value="AEB45508"/>
        <property type="gene ID" value="VAB18032_22040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22040"/>
    <dbReference type="eggNOG" id="COG2732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2232938_0_0_11"/>
    <dbReference type="OMA" id="MENAQWF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12250" checksum="19B13D0B5DF0E2D8" modified="2011-06-28" version="1">MALAHRIDAADRPPGTTYDLDGRYVTDIEGFYCAIGEAINGPGGYFGWNLDALHDCLRGGFGARTPFRLVWHDSAVARAHLVAGCDGRRLAPATTLDDLLDILAAHQVEVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5W9</accession>
    <name>F4F5W9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_22140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734181.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22140"/>
    <dbReference type="EnsemblBacteria" id="AEB45528">
        <property type="protein sequence ID" value="AEB45528"/>
        <property type="gene ID" value="VAB18032_22140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22140"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309201_0_0_11"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="615"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="690"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1159" mass="127245" checksum="B6BA6505181537C0" modified="2011-06-28" version="1">MTGIEIPRGRLAPLSFPQEQLWLMESLAPGTYNEVWVLRIEGDLRVPLLQRSLDLILSRHEVLRSTFDAVDGTPVCRIRPELTIDLGQPTDLAYVPVALRDQMVADLAALVADPPYDLRNGPLVRAALLRLDDAEHILVLATHHIVADGWSLRVVLHELLAAYEAFAAGRAPELPPLPCQYRHFAEEQRRLLDGRELAEEQRYWRTQLDGAVPVLPLRTGGLRPPVKSPHGRRIQVTFPASLARSLHRHATGCRSTPAAVLLAAFTAVVHRYTGRRDLLIGTASAARPDEQWEPLVGFFATTVPLRLRPRPDQSFHELVRHVMEVSLDALDHDRLPFSHLVDLVRPDRDPSYHPLIQVVFSHADVRDAELTGETLRLRYEHVPRSRSRFDLIVEAQTSPTSIGFWLEFDEQLLPEPFVRALFDHLRTLLAAAIEAPGMALTDLPMLSAAERAVAIAEVPPVGVPVPAAEQVVQGLDTLAPQGVVGRIVAVDPQHVRLVGDRLLPVHGQTLTDTGDLGYVDRRGEIVRLGPRDQHPVINGLTVPLDEVAATLSVHPGVRAAEVGYDGTPPVLRARVTCAGDPVPTARQLAEFLATRLPRYAIPDVIDVDRPAAESTGDSAILDPVRQSWRQVMGRDDLDDDDDFFALGGHSILAAELASRLRTELGRQVPIRWIFEAPTVRSLARRIEREDTAGPARAHVAAPTGTPTLGSGSRAAPGPGAEPAGAAPLTAAQTQIWVLDRLAPGRATYHSPLRVDIDGTLDVAALRQAFAQVVERHEMLRSVIRFVVDRPVQVPQPQGPQLSVTDLSALPPQAQAAEIDRLAQAQALRPFDLAREPGIRATLVVGADARHVLLLTVHHIAMDGVGFQVFCRDLSACYNALVGGENPPATAGGLTWQQYACWEDEWLGGPEPARLWAYWEQALAGLPVLAVPTPLPRPPLPTFDGDQLTILLDQEQTAEVLRLATTRRVSPFILVTAAQAALLHHLSGSDDVPIGTVGENRRLPGAQELLGCTIATLVLRVDCAGDPSFAQLLTRVRDTVLGAYDHQGLPFPQLVRAAAMPRHLDRLPLFQVAVEWQEPDRSGWNLAGCTVDWHFTRLDTARNDLYFTAALRADRLELSVEFNTNLWDAPTARGLLTRWRDLLVAATRRPDQRLSELAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Z6</accession>
    <name>F4F5Z6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734208.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22275"/>
    <dbReference type="EnsemblBacteria" id="AEB45555">
        <property type="protein sequence ID" value="AEB45555"/>
        <property type="gene ID" value="VAB18032_22275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22275"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="27159" checksum="630689C9500AB7C9" modified="2011-06-28" version="1">MRLSGKVCLISGGTAGIGLTTAELFARHDAQAVVVTGRDPERGAEAVERLGGNAWYLPQDVVDEDRWDAVVDAVVARYGRLDILVNNAGWIGDEQAQDIEEVELEQWRRILAVNLDSVMLGCRAAVRVMGANGGGSIVNVSSTAGLMSTPLFTAYGAAKAAITQLTKSVAVHCAWRRYGIRCNSVHPGLIETDLGDRVLALFDPDVDRARTAYLARVPMGELGTPDDAAAAILYLASDESRHVTGTQLVVSGGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F612</accession>
    <name>F4F612_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol-3-phosphate transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_22355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734224.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22355"/>
    <dbReference type="EnsemblBacteria" id="AEB45571">
        <property type="protein sequence ID" value="AEB45571"/>
        <property type="gene ID" value="VAB18032_22355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22355"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="RPRNIFV"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="35666" checksum="FF4D33334C0063CF" modified="2011-06-28" version="1">MRGVIRLEALTRSYGGRPAVDGVDLEVAAGELITLVGPSGSGKSTILRLIAGLDRPDSGRILVDDVDVATVPPPRRAVAMVFQDYALFPHLTVLGNLTFGLRVRKVRRAEAEQRARAAAQRLGIDGLLDRYPDQMSGGQRQRVALARALLRDPSVYLLDEPLASLDGPLRFATRTDLLALHRELRTTTIHVTHDQHEAMTLGDRVVVLADGQIRQVGPPQQVYDEPADTFVAGFLGSPPMNLVPGGGVLGGDATLTIGVRPEDLALDDAGPVTATVEAVESLGSEANLSTRCPDGTRLIVRTGPRPGVALGDEVRLRADRLHRFDATTGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6L6</accession>
    <name>F4F6L6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_16190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16190"/>
    <dbReference type="EnsemblBacteria" id="AEB44344">
        <property type="protein sequence ID" value="AEB44344"/>
        <property type="gene ID" value="VAB18032_16190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16190"/>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013924_1_0_11"/>
    <dbReference type="OMA" id="MATGNAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041372">
        <property type="entry name" value="Cas3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18395">
        <property type="entry name" value="Cas3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB44344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="916" mass="100154" checksum="E63E98075F2DBDEC" modified="2011-06-28" version="1">MGWLPLWRHLADTADVAGQLWDHWLGRAARHRIADELPGAEADARTLLVWLAGIHDIGKATPAFAYQAYNLAERMRDHGLGYQRDLIKADRRYAPHATAGHVLLADWLHQQDWTDPHPFAVVVGGHHGVPPTDMGLRDVRVRPHLLGGPAWQHVQHELLTWMTQRSRAGDRLADWNGVALSQPVQALLTGLVIVADWIASNENYFPYLLTGSDEDRLRTGWELVDLPVPWRPTAPPANVDELFRARFALPTGATPRPVQRTVVDLAETMPTPGMMIVEAAMGEGKTEAALAAVEILARRTGASGCYLALPTRATSDAMFGRMLSWLRRLPDTQVGRGDRDVRLAHGKAALNPDYDHLRTTSLPSGIGEDTGGADIGVHRWLAGTKRTMLSSFVVGTIDQLLFAALRSKHLVLRHLGLAGKVVVIDEAHAYDVYMGRFLDRALEWLGAYGVPVVVLSATLPAHRRAELMKAYDDGRLGPPPPLTWRDRGRPQVDPYAALRSDLRYPLVTVSTDQRGAAAISCGDSGRGIDVTLRRLPDDLPALVDLLRDRLAEGGCALVVRNTVARVQESAAVLRAALGPDTPVSVAHSRFMAVDRAAKDRWLRDTFGPPGSNNRPHRHVVVASQVAEQSLDIDFDLLVTDLAPVDLVLQRIGRLHRHPRADRPARLTEATCWITGADWSVEPPQPVTGSRRVYQPATLLRSAAVLLPHLDGTPVRLPHDISPITQTAYGDAPVGPESWQPSIVEAETKQRDEIASKESKADSFRLAGVAEPGVPLIGWLSGGVGDAEERVAQGHVRDTDADSLEVLLLVRTPEGLVLPPWIDGGGVRVPIASSPSSTLARSIARCTLPLPRAMTSADVIDGVIGEIEGRVDVRAWQENPWLAGELVLDVDGEGHGRIGPFDLYYEPHEGLRVFRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6P9</accession>
    <name>F4F6P9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class v</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_16355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16355"/>
    <dbReference type="EnsemblBacteria" id="AEB44377">
        <property type="protein sequence ID" value="AEB44377"/>
        <property type="gene ID" value="VAB18032_16355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16355"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_0_11"/>
    <dbReference type="OMA" id="LFCAHPL"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="27"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="417" mass="43711" checksum="0E89E8069D03F2D1" modified="2011-06-28" version="1">MPTIAPVVLGADLPVRLSDGTTVTYANLDYAATAPCLAAAADAVNELLPWYASVHRGAGAASRRCTLAYEQSRQTVADFLDIRPDDHVIFTRNTTDAMNLLARALPSHTTVVTWAGEHHANLLPWPRVHCLPVPADLPAVVSGLTRALADLRSAGPVLVAVTGASNVTGEVWPIAELAEIAHRHGARIAVDAAQLAPHRPVSMTDAGIDYLALSGHKLYAPFGAGVLAGRADWLDAAAPYLAGGGATRHVGDEAAEVQWHVGPARHEAGTPNLLGAVALAAACATLAASPAVLAHEQDLLKRLRDGLAALPGVAELRTFDVGHDRVGIVSFAVAEQRATEVAHRLAADHGIGVRDGLFCAHPLARKLLTDAAERLGCPTDRYAIRASIGIGTTVAHVDRLLRGLREIVTSSRAAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6R2</accession>
    <name>F4F6R2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_22435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734239.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22435"/>
    <dbReference type="EnsemblBacteria" id="AEB45587">
        <property type="protein sequence ID" value="AEB45587"/>
        <property type="gene ID" value="VAB18032_22435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22435"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="OMA" id="FRRFHSV"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309123" description="Histidine kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="181"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="241"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="451" mass="48781" checksum="E1EF23BD3451CCCB" modified="2011-06-28" version="1">MRRLGLRARVTAAFAVGALLLSASMALVSYELTRRTLLDERERTVLRAAYYDAAVVRAGLDTENPDAGEALRTLDTGTGRRAVLHLNGDWYGRAADNGLTAAIPARLRELVSAGEPAVQRIRVDDQPVLLVGVPLSESASFYEIASLRELEQTFQVLALALTAVAIMVAGSGAALGWYATRHGLRPLTAVADAAERIAAGDFTTRLAPDTDPDLTRLSTSFNRMVDELAQRIDRDRRFAADVSHELRSPLQTLAAAASVLSRRRDNQDERTATAARLVADEIDRFQQLVNDLLDLARSDQSVHRQPVDVAELARQVCRDRDLPETMVRLTEDTPATWRVDRRRVAQVLTNLLDNAERYGAGPVAVLLSRTGDTGVIEVDDDGPGVPVEDREAIFDRFVRGRAAHYRGGGDGTGLGLALVAQHAAAHGGSASVSDRPEGGARFRITLPGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6U9</accession>
    <name>F4F6U9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734276.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22620"/>
    <dbReference type="EnsemblBacteria" id="AEB45624">
        <property type="protein sequence ID" value="AEB45624"/>
        <property type="gene ID" value="VAB18032_22620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22620"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151893_0_0_11"/>
    <dbReference type="OMA" id="WHLTIAD"/>
    <dbReference type="OrthoDB" id="2033818at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="129" mass="14272" checksum="2B70BE26595341D4" modified="2011-06-28" version="1">MSESVRAFFDDLTHSGGRMLRKVSGSVRFDLAHPRGVDHWLVTIDQGRITVSQGGAVEADTVIGADETLFLRMAHGEIKPLSAWLRNDFTADGEFRFVIMLERLFAPPKGARHPRVAAMLPSADDREPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6V4</accession>
    <name>F4F6V4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_22645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734281.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22645"/>
    <dbReference type="EnsemblBacteria" id="AEB45629">
        <property type="protein sequence ID" value="AEB45629"/>
        <property type="gene ID" value="VAB18032_22645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22645"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_2_11"/>
    <dbReference type="OMA" id="RYLAMDV"/>
    <dbReference type="OrthoDB" id="1694312at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="29334" checksum="772E3407ADEC12EA" modified="2011-06-28" version="1">MTRATAVRPAPVTAPPAAPGGPARPGRGLAWRRSTTPLLLVLGWELAARSGVLAAEKLPAPSAVLATGWRLTRDGTLLTHLLDSLTRAGVGLLIGGGLAVLLGALAGLLRIGDDLVDPPVQMARMLPHLGLVPLLIIWVGIGESLKISLVALGAFFPLYFNTYAGIRDIDERLVEAARTCGLGALARLRHVVLPGALPALFLGLRLAIGAAWLSLVVGEQVNAQTGIGFLMMEAREFSQTDVVVLGLLVYALLGLLSDVAIRIVERRTLTWRRGLRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Y7</accession>
    <name>F4F6Y7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734314.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22810"/>
    <dbReference type="EnsemblBacteria" id="AEB45662">
        <property type="protein sequence ID" value="AEB45662"/>
        <property type="gene ID" value="VAB18032_22810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22810"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_4_11"/>
    <dbReference type="OMA" id="IYTEYSM"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="233" mass="25349" checksum="CDC23A485BE1EA9E" modified="2011-06-28" version="1">MVNGKRLLVIIPALNEAGSIADVVREIRGELPGVDVLVVDDGSADRTAAVAAAAGARVARLPYNLGVGGAMRLGYRYAHDHDYDVAVQIDADGQHDPRYVPKLVDLLDDYDLVIGARFAGEGDYAVRGPRRWAMGMLSMVLSGLAGTTLTDTTSGFRAANRRMIEMFARWYPAEYLGDTVETLVHAARRGYRIQQVPVAMRRRMAGTPSHSPAKAMIYLGRALAVLTLALIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F708</accession>
    <name>F4F708_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735521.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46872">
        <property type="protein sequence ID" value="AEB46872"/>
        <property type="gene ID" value="VAB18032_29006"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29006"/>
    <dbReference type="eggNOG" id="ENOG5030IIW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148462_0_0_11"/>
    <dbReference type="OMA" id="MFCAYSS"/>
    <dbReference type="OrthoDB" id="1915490at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028956">
        <property type="entry name" value="Imm51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15595">
        <property type="entry name" value="Imm51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="13035" checksum="659BC48D96847976" modified="2011-06-28" version="1">MLDDPATFAPFVLLEYPHAPGTYCLILTNEQMEEVAERFEEAGAEGNGHDWEALAEAVVQTREPGLADDLSFTSESGTFAVNSTNLDALRRLASILHSAYHDEALLSALLRDAGPDTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7A4</accession>
    <name>F4F7A4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10220"/>
    <dbReference type="EnsemblBacteria" id="AEB43162">
        <property type="protein sequence ID" value="AEB43162"/>
        <property type="gene ID" value="VAB18032_10220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10220"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_3_0_11"/>
    <dbReference type="OMA" id="QNDMVAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312747" evidence="2">
        <location>
            <begin position="41"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="150"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="266"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="473" mass="49974" checksum="78D0EFDB4A4E69F8" modified="2011-06-28" version="1">MTPSHESSTSIGSGFLNRRRVLTVALGGAATVALPVPAWAANGQRPGSHQAPKLTSDDRKVIAQISSRRALEHLVQLSENIGPRIGGTESERRAADYIAAHFDKLGYDTTLQPFTVADKFTGQLSSPAGLPTDLNWQTGASAHAALNTSVTGAVVDVRAGAASDYPADVRGKIVLVDYVANRREQVVATAVAAGAAGVILLAADAAAPRLAGTFSPTLPGSANNPVPIPVLGVAQSQKNRLRELLAAGPLTLTVATTAHRNLTSNNVLAERVGRSGANGPIVMISAHYDTVIGAPGANDDGSGTALCMELGRVLKAIPTNATIRFGLWGSEEQGLIGSRYYVRQMPQAERDRILAVYQNDMVATSWDPATRYWLLSFDGQDNRATAEVAASARRLGYEPQISPVTQRGSSDHQSFQEVGIASANFSWRGEESPALLEPPYHTPEDTIAKNISLERLQVSMELIGTAAYATARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7K5</accession>
    <name>F4F7K5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_16700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733103.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16700"/>
    <dbReference type="EnsemblBacteria" id="AEB44444">
        <property type="protein sequence ID" value="AEB44444"/>
        <property type="gene ID" value="VAB18032_16700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16700"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_4_0_11"/>
    <dbReference type="OMA" id="GAWLSYY"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022392">
        <property type="entry name" value="Anch_rpt-typ_ABC_trnsprt_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03770">
        <property type="entry name" value="anch_rpt_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="32613" checksum="C7863B69FA7D7D0E" modified="2011-06-28" version="1">MSITDFLTDLLNPDLAFLPKALAIAVMSSIVCGVVGCYVVLRGMAFIGDAVAHAVFPGIAVAFVLQGSLVLGGAVAGVATALLIAIFAQNRRVKEDSIIGVFLVGAFALGIVIISQAPGYAGSLQQFLFGSITGIPDRDLYVVGGASLVILGLALALHKEFVAVCLDREMSRAMGLAVFWLDIVLYVLVTLAVVISLQTIGNILVLALLITPAAAARLLTDRLGVMMLLAPVIGGASATVGLYLSWSYDTPVGGTIVLIATAVFLAAWLIAPRHGLLTKRWRRSRHESTDDTRRAPLSDLARPQAPSPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7S9</accession>
    <name>F4F7S9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23080"/>
    <dbReference type="EnsemblBacteria" id="AEB45716">
        <property type="protein sequence ID" value="AEB45716"/>
        <property type="gene ID" value="VAB18032_23080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23080"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102191_1_0_11"/>
    <dbReference type="OMA" id="ERYLAMT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="135" mass="14869" checksum="53ECC7CF8F57867A" modified="2011-06-28" version="1">MLARHGRYLAMPATGRGEMFVVLLGDEMVGSIGYHKRDWQGEQIYETGWNVLPPWQGRGAASAAGTALISMLREAARHHDAPDSLHAFPSVENTASNALCRRLGFTLLGPCDFEYPPGSGILMRSNDWRITLTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7X0</accession>
    <name>F4F7X0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29371"/>
    <dbReference type="EnsemblBacteria" id="AEB46945">
        <property type="protein sequence ID" value="AEB46945"/>
        <property type="gene ID" value="VAB18032_29371"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29371"/>
    <dbReference type="eggNOG" id="ENOG502ZUTQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760340_0_0_11"/>
    <dbReference type="OMA" id="DGKDWKS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307714" evidence="3">
        <location>
            <begin position="35"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="34634" checksum="638475571F87F1AE" modified="2011-06-28" version="1">MTQVMAKKMLGKVVAGAALGGASLLVFAPGAAFADGQPHENEGKVFAKPHAAKPGEEIKLVEICEKPQENAFVWSKVTGKVKLEPARDGGKWDRGGWNGEDGSYEHGKDGKDWPGREHEKDGKDWKSDKDGKDWKSDKDGKDWHGGEEGKDWKGGEDRGGDWKPGEEGGEWQGREDAPQAGAGGGAASDEDRDWKSDEHGQDAEGERDWKGREDDKHGEKSESDWKDRGEHGKGDGWEHEKDFVYYGEARIAKDAKPGTYKLEGSCGEGELVVLPHGGVDGGDGGLTAGTDRSMATAGAGLVGAAALGGLVLLRRRRTDEFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Y5</accession>
    <name>F4F7Y5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735608.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29446"/>
    <dbReference type="EnsemblBacteria" id="AEB46960">
        <property type="protein sequence ID" value="AEB46960"/>
        <property type="gene ID" value="VAB18032_29446"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29446"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_0_11"/>
    <dbReference type="OMA" id="VIRCDDL"/>
    <dbReference type="OrthoDB" id="1478362at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="266" mass="29656" checksum="46658AA1EAFF9AD1" modified="2011-06-28" version="1">MEESSADLIRSQLRRLRTAAGLSQEEFGKLVHYSPSMVSAVETGSRPYDRQLLARADEVLRSGGLLVALLRIAEREGQPSWFLPWLDAERLASQLRIFQPTLIPALLQTEGYARAVIRCDDLLSDEEVDKRVAARMDRQAILTRPDPPQLIAVIDEAVLHRREERFHALMVHQVEHLIASAERPNVSIHVIPLSVGLHIGLSGPFSLARGAEGGWVASQEAQLTARPTDGESDVATLLARWETVRNDALSRQQSIELLKEVAKSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F892</accession>
    <name>F4F892_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731924.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10675"/>
    <dbReference type="EnsemblBacteria" id="AEB43253">
        <property type="protein sequence ID" value="AEB43253"/>
        <property type="gene ID" value="VAB18032_10675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10675"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118224_0_0_11"/>
    <dbReference type="OMA" id="LGLADNY"/>
    <dbReference type="OrthoDB" id="1429052at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="189" mass="20114" checksum="81FF1D51812A26B7" modified="2011-06-28" version="1">MTSGHLQIVVCGAGPASDVAHLVRAAQQQSWTAAVTATPSAMAFIDVPGIEELTGAEVRSSYRTSPSGRRSLPSTDALVIAPATYNSINKIALGLADNYAMTSVAELIGRQVPTVIVPFVNAALAARAPFRNAVASLRDEGVRVLLGPDHQWEPHPPGSGNERQRSFPWTMAFETAAQLRQLVRDTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8K1</accession>
    <name>F4F8K1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FBP_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734396.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23230"/>
    <dbReference type="EnsemblBacteria" id="AEB45744">
        <property type="protein sequence ID" value="AEB45744"/>
        <property type="gene ID" value="VAB18032_23230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23230"/>
    <dbReference type="eggNOG" id="ENOG5031HHY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116295_0_0_11"/>
    <dbReference type="OMA" id="WRDPQAP"/>
    <dbReference type="OrthoDB" id="1684141at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBP_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="17488" checksum="F8F25107955E60C1" modified="2011-06-28" version="1">MEALTESEIRAAFVNCSKGEAKRLFVPRDLATRPWADLDYLGWRDPKAEDRAYLVTEQAGRPTALVLRRPSAAAGRGSRNMCSICLTSPEAGVSLLVAPRAGRAGRDGGSVGTYLCSDLSCSLYLRGKKDAGAGARLHETISLDEKIARTTTNLAGFIAKVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F905</accession>
    <name>F4F905_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735732.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00005"/>
    <dbReference type="EnsemblBacteria" id="AEB47085">
        <property type="protein sequence ID" value="AEB47085"/>
        <property type="gene ID" value="VAB18032_00005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00005"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102964_1_1_11"/>
    <dbReference type="OMA" id="RTPERDW"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="168" mass="17517" checksum="C3DA258A66AE1B5B" modified="2011-06-28" version="1">MTGPLVRPAVPADYPAVARLTVAAYEADGQLKGENGYADVLADVAGRAAHGEVLVAADPATGQLLGSVTFVLPGSPYAELCGPGEAEFRMLAVDPAAQGRGTGAALVEACVARATELGCTALVICVRDGLAESAHHLYRRHGFTRTPRLDWTPLPDVHLLALRRPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F914</accession>
    <name>F4F914_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730716.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04580"/>
    <dbReference type="EnsemblBacteria" id="AEB42042">
        <property type="protein sequence ID" value="AEB42042"/>
        <property type="gene ID" value="VAB18032_04580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04580"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972648_0_0_11"/>
    <dbReference type="OMA" id="RETGWPM"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="284" mass="31881" checksum="DC5822F600E35901" modified="2011-06-28" version="1">MTSPHGRTERPEARHQQVARNIRNEIEAGRLVHGTALPSTRKLAEEWGVSVFTITEAMKVLAEEGLVINESRSKRVVNAPDQLRRSEVRPQRPRVILIGGYAGSGKTELGRILARETGWPMLDKDTLTRPVVEAALETLGQSPHDRESQTYLDTIRPREYEALQDAASENVQCGNSVIVTAPFIREFNDPAWMARTRAYYEAAKAIPTVVWVYCDGDTMLTYVRRRGAARDAFKLADWDRYLSGINLDFRPPGDHFVVDNCASSRPLQEQAKELVKAILADEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F933</accession>
    <name>F4F933_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42061">
        <property type="protein sequence ID" value="AEB42061"/>
        <property type="gene ID" value="VAB18032_04675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04675"/>
    <dbReference type="HOGENOM" id="CLU_2848624_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="6440" checksum="634F437AA2F5FC8F" modified="2011-06-28" version="1">MDVSDNQDGFAVVVAAFPKDDGGGGGGLPVTGPQAGLITGAGLAMLTVGGILLLLARRRTRLPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9B4</accession>
    <name>F4F9B4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731979.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10950"/>
    <dbReference type="EnsemblBacteria" id="AEB43308">
        <property type="protein sequence ID" value="AEB43308"/>
        <property type="gene ID" value="VAB18032_10950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10950"/>
    <dbReference type="eggNOG" id="COG1119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OMA" id="HVLMIRQ"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="29704" checksum="351C81134047C06F" modified="2011-06-28" version="1">MTGDLIAGAGGATPAPASMDADLVVSLDGVGVRRSGTALLHDVEWRVEADERWVVLGPNGAGKTTLLNLAAGRLHPTTGVAHVLGERIGRTDLNELRTRIGLTTAALAERLPADEKVRDVVMTAAWSVVGRWREEYDPADEARALALLDQLGAGALADRDYGTLSDGERKRVQIARALMTDPELLLLDEPAAGLDLGGREDLVARLAMLAQDPDAPALVLVTHHVEEIPPGFTHAMLLRDGAVMAQGPLEVTLTADNLTKTFGLPLLVDRTGDRFTARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9J3</accession>
    <name>F4F9J3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17345"/>
    <dbReference type="EnsemblBacteria" id="AEB44571">
        <property type="protein sequence ID" value="AEB44571"/>
        <property type="gene ID" value="VAB18032_17345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17345"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712502_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="16649" checksum="B3C6AB3AFD0BB069" modified="2011-06-28" version="1">MLINNGAAYIEGEDLADVSDDVIDSVMAAGGTGTVLLTKHLLPLLRASSRPDIVNMISACGEVGHRRSGAHPAFYAAKHAHAGLAEILSHRLRPEKIRVISLFPPDFVQDGPRQADSDLTARSVIDCVLFAVGQPRDCFIREFHFEQVRNPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9S2</accession>
    <name>F4F9S2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_23750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734500.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23750"/>
    <dbReference type="EnsemblBacteria" id="AEB45848">
        <property type="protein sequence ID" value="AEB45848"/>
        <property type="gene ID" value="VAB18032_23750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23750"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_11"/>
    <dbReference type="OMA" id="RAYCGAP"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="417" mass="43997" checksum="06342928EA055849" modified="2011-06-28" version="1">MNEHRRAVVTGIGVVAPSGVGAEAHWRTVLAGQRRTGPITLFDAADYPTRLGGEVPDFDPARYTDNRVLVQTDRWTHLGFAATRLALRDAGLPERPADPYGWAVTLASSSGGNLFGQRELQRLWSSPSRTVGAYQSIAWFYAASVGQLSIAHQAKGPCGVLVAESAGGLDSLAHAVRTIRRGASVVLAGATECPLSPYALACQLRSGLLSAVDDPQRAYQPFDVSASGYLPAEGGAVFVVEEYEHARARGVRGYGEVTGWGATHDAAHTTAESAGDPHQYARAMRLALGRAGVEPHEVDLVVPDALGVARYDRAEATALRAVFAGTAPAVSTHKALTGRAHQGGSALDVATLLLAFAHDTLPPSAGPEQVAEGCELDFLRERRRPRTRVGLVCARGFDGFNSALVLRGTAPAGKDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9V6</accession>
    <name>F4F9V6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734534.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23920"/>
    <dbReference type="EnsemblBacteria" id="AEB45882">
        <property type="protein sequence ID" value="AEB45882"/>
        <property type="gene ID" value="VAB18032_23920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23920"/>
    <dbReference type="eggNOG" id="ENOG5031QBZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1667362_0_0_11"/>
    <dbReference type="OMA" id="RHSFVEW"/>
    <dbReference type="OrthoDB" id="2098916at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="15395" checksum="5D63589F15D86AA8" modified="2011-06-28" version="1">MGGRQKVLVVGLGVLLVVLFVVAVGGGRGERGDPAGRHSFVEWLGRGGGGRGAVDPATVEAECVEAPGRLAVVGDCELRVADPGRLRTLILRSPGGFTVEAPAPGDADVTVTDTVTPQQDGTEAVARIAVDRPATVTLRCPTGCLVTISTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Z0</accession>
    <name>F4F9Z0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding region ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00085"/>
    <dbReference type="EnsemblBacteria" id="AEB47101">
        <property type="protein sequence ID" value="AEB47101"/>
        <property type="gene ID" value="VAB18032_00085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00085"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133205_0_0_11"/>
    <dbReference type="OMA" id="RHSVTSC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="145" mass="15742" checksum="A70285C1C1265349" modified="2011-06-28" version="1">MVPIEHALLIADAFDQAQVTELRHSVASCAHAAGLRDERLDDFVLAVNELITNAVRHGGGQGWLRLWAEPGQLLCEVSDHGRGISAQRLDNRNRPAPDTAGGWGLWLARELTDAMDVATGPAGTTVRILTATVVTEQHIGRHRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA12</accession>
    <name>F4FA12_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00195"/>
    <dbReference type="EnsemblBacteria" id="AEB47123">
        <property type="protein sequence ID" value="AEB47123"/>
        <property type="gene ID" value="VAB18032_00195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00195"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_1_11"/>
    <dbReference type="OMA" id="RLMRYEY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="60"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="182"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="441" mass="46636" checksum="22972709E50AABA7" modified="2011-06-28" version="1">MSARALPPLGPTRRLKLPSQAERTLGNGLTVIAVRRSAVPLVELRLWMPFGRAHLARGQLLAQTLLSGTETMSSVQIAAELQKIGGGLSAGLDPDRLMLSGTGLATGLDRLLEILAEVLTGANYPAEWVATERDRMVDGIQVARSQPAHLVRTALLKRIYGKHPYAVQTPEPEQVRAVRPAALRTLHAQRVHPAGAVLVLVGDVRPERALDAAEKALGGWKGDGHSATPPPAPPLVPGPLLLIDRPGSVQSSLRIALPGVPRTHPDHAALQLANLIFGGYFSSRWVENIREDKGYTYGPHSVVEHSVAGSLLVAAAEVATEVTAPALLETHYELGRLATLAPSEEELEQARQYALGTLQLGVSTQAGLASLVSAYAGNGLRLDFLSEHAARLARATVDDVAAVAARYLAPSRAVTVVLGDAERIADPLGTLTSIETAPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAN1</accession>
    <name>F4FAN1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733301.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44646">
        <property type="protein sequence ID" value="AEB44646"/>
        <property type="gene ID" value="VAB18032_17720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17720"/>
    <dbReference type="eggNOG" id="ENOG50321PA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151362_3_0_11"/>
    <dbReference type="OMA" id="IQATEDM"/>
    <dbReference type="OrthoDB" id="2020318at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="77" mass="8520" checksum="58948A933C2AAE5C" modified="2011-06-28" version="1">MTTHGPVMPIWSCGGCDLPWPCPTRRRELRAEYAGAPVSLALYLGVCLVQAAEDMPWAPAGALHRRFIGWARQVPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAS8</accession>
    <name>F4FAS8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733348.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17955"/>
    <dbReference type="EnsemblBacteria" id="AEB44693">
        <property type="protein sequence ID" value="AEB44693"/>
        <property type="gene ID" value="VAB18032_17955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17955"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033540_1_0_11"/>
    <dbReference type="OMA" id="MTHRRDH"/>
    <dbReference type="OrthoDB" id="1759737at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="379" mass="40648" checksum="ADA5427D2D8C8749" modified="2011-06-28" version="1">MTHRRDHNSVPLGRRVAELRAHRGMSQQAFADRLGKSKSWVDKVERGVRRLDRYSVIRDIAEVLRLDPTMLLGPRQPPTPAAAENGIDAVRAALARCHHRPQPTVTAQQAGGQVAYAWLAYQHARYPQLLGVLPDLLDATHGTRGLLVSAYRLTAHVLVKLDHADLAWLAADRAVTTSAGDPTRTASATIAVAQALRALGHHRIALTAALAAADPADDDTVRGSLYVQAGLAAAGYGDRRNAHDLLDHAAALADRQVSDTDPHYTGFGAAAVQTARSLAAHRLGDTAEAILRHDHVIRSDAWSRLPPEHRAAHLIDAARAHLDASRHSRAGQALLAADRIAPAEVRNRPVARTLLAEIIRGGPAAADVARLATAVGLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAT9</accession>
    <name>F4FAT9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribokinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18010"/>
    <dbReference type="EnsemblBacteria" id="AEB44704">
        <property type="protein sequence ID" value="AEB44704"/>
        <property type="gene ID" value="VAB18032_18010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18010"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_5_2_11"/>
    <dbReference type="OMA" id="MADARHI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="33"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="331" mass="34156" checksum="CE029829AD213ACC" modified="2011-06-28" version="1">MTRILVSGSIATDHLMTFPGRFAEQLIADRLHTVSLSFLVDGLVVRDGGVAANIAYGMAQLGMPPTLVGAVGPDFADYRSRLERHGVDCGSVLTSRSSYTARFVCTTDQDSCQIASFYPGAMAEAADIDLAAVIGSEPVDLAVIGPDDPVAMRRHAAACRRLGVPFAADPSQQLARMSGPDIADFVTGARYLLTNEYEYDLLCGKLGGAGATVLDAVDVVVTTLGEDGVRIRAGGGITRIPAVTGASVVDPTGGGDAFRAGFLYGVTHGLLLDVAAALGCQMGAYAIGAPGTQEYRVVPDRLVANLSDTYGHRVSVAVAEVLTSCAAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAV6</accession>
    <name>F4FAV6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_24105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24105"/>
    <dbReference type="EnsemblBacteria" id="AEB45919">
        <property type="protein sequence ID" value="AEB45919"/>
        <property type="gene ID" value="VAB18032_24105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24105"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_11"/>
    <dbReference type="OMA" id="QLPWFTL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="122"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="344" mass="36294" checksum="A2B29A77ED8E4316" modified="2011-06-28" version="1">MEHPHLDPAIVTAPTRARPRRRTGAGRMIRNRLLVAVPVLFATSAGMFALGAASPIDPAQQYAGAAAFTTSEENLAQIRANWGIDDPLPVQYLRWLGNLLQGDLGWSTSRHEPVVDVLAARAGWTLLLVGAALVVVLVASLLLGTLAAYRRGGWFDRALRTTAYAIQSVPSFWLGLAAIALFALSLGWLPAGGLTDITATSTDVADVARHLILPVGVLAVSQLPWFVLFIRDSVADSLRDDHVLAARARGLPGRTVLFGHALRTGLLPFLTLIGTHLPELVGGAVLVETVFSLPGLGAVTVQAALGSDFPLLAAITLATTVVVLAANLATDLAYAAADPRVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAZ2</accession>
    <name>F4FAZ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45955">
        <property type="protein sequence ID" value="AEB45955"/>
        <property type="gene ID" value="VAB18032_24285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24285"/>
    <dbReference type="eggNOG" id="COG4427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065141_0_0_11"/>
    <dbReference type="OMA" id="WFSWKIG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011200">
        <property type="entry name" value="UCP012608"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10094">
        <property type="entry name" value="DUF2332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="357" mass="37705" checksum="57E06F0473AD920E" modified="2011-06-28" version="1">MFRAARGFDSSPLYRHLLAVVADEPALVELAERTRPGQQPTFALFGAVHQLLLGGVTDPLAAYYPSVVGARARPVDADTGRAFTRFCLAHADRIAAILATRLVQTNHVQRSLVTRLGLALLRSATAAPVCVVEVGCSAGLNLRADRYAFSVGDSTVGDYASGGRWSPRGGSRVHIRVDVPDGRLLPDLDRLPVVADVVGVDLDPPDLTDPEDRAWLRALVWPENAHQAALLAEAMRVVADDPPRVLRGDVADIGAEVAASLPAGLPRLVVHTATRIHVPVDRRPAFAAAVAAFAADGPMLHLALEDDHRIAPSGRAGIGLTATDAAGSRRIAVADGHLAWLEPLPELGTPIVLGAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB65</accession>
    <name>F4FB65_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_00630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00630"/>
    <dbReference type="EnsemblBacteria" id="AEB47210">
        <property type="protein sequence ID" value="AEB47210"/>
        <property type="gene ID" value="VAB18032_00630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00630"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036172_0_0_11"/>
    <dbReference type="OMA" id="IIGRMER"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="8">
        <location>
            <begin position="293"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="398" mass="42741" checksum="40D1A585318114EA" modified="2011-06-28" version="1">MAAGVAAGIAEHLGVPVVRVRVAFMVLLGLSGLGLLLYAAFWAVVPLRPGDTAAPPRRDVTQLLPFVAIGLGVLLIQVLVFDSVGVAGTAGWLVAIIAVGAGVIWHQSGPERRRQWNESMPVPWLSAVVEESDRRAFVLRFVGGGVLVAVGIIGVAAVYSPAQNLDAVVNGVIFALVGLAGVGVVAAPVLWRTWNQLRSEREGRIREQERAELAAMVHDQVLHTLALIQRNASDVKMVQRLARGQERSLRNWLYKPTASPTERFAAALEQAAAEVEDTFAITVEAVVVGDRETDERVGALVAAAREALVNAARHAGVQTVSLYAEVEPDQVSVFVRDRGAGFDPDTVEDHRHGVRGSIIGRMKRHGGRAEIRSRPGEGTEVRLILPIARDSATAERDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB78</accession>
    <name>F4FB78_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="4">IMP dehydrogenase</shortName>
            <shortName evidence="4">IMPD</shortName>
            <shortName evidence="4">IMPDH</shortName>
            <ecNumber evidence="4">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">guaB</name>
        <name evidence="12" type="ordered locus">VAB18032_00695</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="4">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 9">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735868.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00695"/>
    <dbReference type="EnsemblBacteria" id="AEB47223">
        <property type="protein sequence ID" value="AEB47223"/>
        <property type="gene ID" value="VAB18032_00695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00695"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_2_11"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="121"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="181"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="4">
        <location>
            <begin position="364"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="4">
        <location>
            <begin position="387"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="4">
        <location>
            <begin position="411"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="4 5">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="275"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="520" mass="54685" checksum="521503B56595ED74" modified="2011-06-28" version="1">MENSPQTDLSAGADAGELGGHLPELPAGSARVVPLGLTFDDVLLQPGESDVVPSRVNTVTRLTRNVTLSIPLLSSAMDTVTEARMAIAMARQGGIGVLHRNLSVEDQALQVDLVKRSESGMITNPVTASPDDTLREVDQLCGRYRISGVPVVDAEGQLVGIVTNRDMRFVSDPATPVRDIMTQPPLVTAPVGVSKDEALGLLRQHKVEKLPIVDGSGKLRGLITVKDFTKSEQYPNATKDDAGRLRVAAAIGVGEDAYKRARALVDAGVDVLIVDTAHGHQRAVLEMVDRLKKDVAIDIVGGNVATYAGAKALVDAGADGVKVGVGPGAICTTRIVAGVGVPQITAIMEAARAARPAGVPVIGDGGIQYSGDIAKALVAGADTVMLGSLLAGCEESPGELIFVNGKQFKAYRGMGSLGAMQSRGQAKSYSKDRYFQQDVTSDEKLVPEGVEGQVPYRGPLSRMAHQLVGGLRLAMGYAGAESIAELHQRGQLIRITAAGLKESHPHDIQMTVEAPNYHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBF1</accession>
    <name>F4FBF1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05605"/>
    <dbReference type="EnsemblBacteria" id="AEB42247">
        <property type="protein sequence ID" value="AEB42247"/>
        <property type="gene ID" value="VAB18032_05605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05605"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_11"/>
    <dbReference type="OMA" id="FPFADRP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="381" mass="40116" checksum="E6E72484D2D9EBEA" modified="2011-06-28" version="1">MIVGAGIAGLAAAARLGRDGWRTTVVERAPGRRSSGYLVNLLGSGYDAAQRLGLLPALSDRALGSFSTVLVRADGRPKFTVPAALAEATLGPHAMTVFRGDLEAALYAAAREHTEFRFGTTVTAIEQDADRVRVTLSDGSTEEADLLVGADGVHSATRTSVFGAQYRVDLPYVVAAVPLAEPVAEVPESSATTFIGPGRTAAVISLGPGRSSAFFTYRCEDPGWEVARGALDALRAAFADLGGGIPEALRQLATDPASAYFDQVSQVVMPRWSDGRVLLLGDAAWCVTLFAGHGAALALAGADRLGTALNRPDQDIPTALAGWGAALRPEVVKRQALARRGMHQYAPPSRVHVWLNDVTMRAITLPGVRGVLRRAVERQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBG8</accession>
    <name>F4FBG8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N6_N4_Mtase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05690"/>
    <dbReference type="REBASE" id="34377">
        <property type="entry name" value="M.VmaORF5690P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42264">
        <property type="protein sequence ID" value="AEB42264"/>
        <property type="gene ID" value="VAB18032_05690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05690"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162747_2_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="125" mass="13825" checksum="B1E73050B4188A1C" modified="2011-06-28" version="1">MLDYDDIVRPMAVRSGMEFTDVWDFMSVRPFKGKHPAEKPLDLLSHMISASSYPGDIVLDCFAGSGSTGVAALRAGRRAVCMEIEEQWCSRAGKELAAAEKGVDLTTTREHHMKKSPVVFDSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBZ3</accession>
    <name>F4FBZ3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase, pfkB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734643.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24465"/>
    <dbReference type="EnsemblBacteria" id="AEB45991">
        <property type="protein sequence ID" value="AEB45991"/>
        <property type="gene ID" value="VAB18032_24465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24465"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_11"/>
    <dbReference type="OMA" id="NDWGAIA"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="150"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="366" mass="40104" checksum="CEA415FE3FD19275" modified="2011-06-28" version="1">MSVLDLRPADRCRYDLVSLGEVMLRLDPGEGRVRTARAFRAWEGGGEYNVARGLRRCFGLRTAIVTAFADNEVGRLLEDLILQGGVDPSFIRWMPYDGLGRSVRNGLNFTERGFGVRGAVGTSDRGHTAASQLRADDVDWDHLFGDLGVRWLHTGGIYAALSETTPETIEAAMVAARRHGTIISYDLNYRPSLWKAVGGQARAQEVNRRLARYVDVMIGNEEDFTASLGFEVPDTDASLSELEVTNFQRMIDEVTKEFDNFRVVATTLRTVRSATVNDWGAIAWGGGRFVEATHRPGLEIMDRVGGGDSFASGLIYGLLEQHDLATAVEYGAAHGALAMTTPGDTSMANRKEVEALMRGAGARVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC59</accession>
    <name>F4FC59_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734709.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24795"/>
    <dbReference type="EnsemblBacteria" id="AEB46057">
        <property type="protein sequence ID" value="AEB46057"/>
        <property type="gene ID" value="VAB18032_24795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24795"/>
    <dbReference type="eggNOG" id="ENOG502ZWR8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2343566_0_0_11"/>
    <dbReference type="OMA" id="MTDDIGE"/>
    <dbReference type="OrthoDB" id="2097870at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="89" mass="9619" checksum="4F01D5D3335109EB" modified="2011-06-28" version="1">MNNDPAELSARIGRVMGEVLVREPLGADEDFFKSGGDSLRAVEMLQRLARLDGWADRLGTPETQARLLEEVFEVATPRALAAAAYASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCC9</accession>
    <name>F4FCC9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ordered locus">VAB18032_01120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735946.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01120"/>
    <dbReference type="EnsemblBacteria" id="AEB47308">
        <property type="protein sequence ID" value="AEB47308"/>
        <property type="gene ID" value="VAB18032_01120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01120"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_3_3_11"/>
    <dbReference type="OMA" id="RFQMATS"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="77" mass="8708" checksum="E9AF20DE0803678C" modified="2011-06-28" version="1">MAAGVKPSELRELSEEELVTKLREAKAELFNLRVQAATGQLDNNRRLQVIRREIARIYTIMRERELGLSAAPTEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCM3</accession>
    <name>F4FCM3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_12015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12015"/>
    <dbReference type="EnsemblBacteria" id="AEB43517">
        <property type="protein sequence ID" value="AEB43517"/>
        <property type="gene ID" value="VAB18032_12015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12015"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_0_11"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="62"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="216"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="468" mass="50333" checksum="18DD42DBB1F02BD5" modified="2011-06-28" version="1">MSRTRRSFPSVARPGATPPGTDRHAVGTIRSAGGSTRAVTRTLSEDPLGGTVRRTVLPSGLRVLTEAIPAMRSVSFGIWVAVGSRDETGPTAGAAHFLEHLLFKGTHKRGALEISSSIEAVGGETNAFTTKEYTCYYARVLDEDLPLAIDVMCDLVADSVLEPADVETERGVILEEIAMHDDEPGDEVHDLFARAVYGDHPLGRLISGTSDTVTPMTRRQIQTFYRRRYVAPQIVIAAAGNLDHAAVVRLVRQALRGTPLDTEPASPAPHRPAAPAVRTRAASTVVQVKETEQAHVVLGCPAIDRLDERRFALGVLNNVLGGGMSSRLFQEIREQRGLAYSVYSYASQYADSGLFGVYAGCAPGRVDEVLELTRTELARTAEQGITEAELARGKGMSKGSFVLGLEDTGSRMSRLAKGELLYGNLMPVNELLDRVDSVTLDDVNTLAADLLARPMSLAVVGPFANRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCP5</accession>
    <name>F4FCP5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732208.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12125"/>
    <dbReference type="EnsemblBacteria" id="AEB43539">
        <property type="protein sequence ID" value="AEB43539"/>
        <property type="gene ID" value="VAB18032_12125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12125"/>
    <dbReference type="eggNOG" id="ENOG5033N0M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097598_0_0_11"/>
    <dbReference type="OMA" id="ARPNTEH"/>
    <dbReference type="OrthoDB" id="1584314at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="27444" checksum="D78D8CE71693DC1B" modified="2011-06-28" version="1">MAADERTRYFRRLGKLRRSARRWSVLAGGFGGATVILTPYAGIGLADAVWAAAAGATTALAAWRWVDLRALAAQPAPPALDPAQAAARNRARLVAAVERLPAGAGVVAEVRRVRTRTALRGTSAAGPWERLDRAATTMAGMTDRLTGLAEPAVAEASVAEHSLRELAHQVASVERAVRLAPADARPPLAEAHEALTGQLEAGVAAYERLVVAAAGYLAEEYRPQLEHPAATRLTEATDLLHGFASALSELRPHPTPGMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCU4</accession>
    <name>F4FCU4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ordered locus">VAB18032_12370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12370"/>
    <dbReference type="EnsemblBacteria" id="AEB43588">
        <property type="protein sequence ID" value="AEB43588"/>
        <property type="gene ID" value="VAB18032_12370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12370"/>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053306_4_0_11"/>
    <dbReference type="OMA" id="HVAMRVH"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="29845" checksum="859EF86E87CB7ABB" modified="2011-06-28" version="1">MTLRDDESVKFTKGHGTGNDFVILPDPDGALDLTPELVAAICDRRRGLGGDGVLRVVRAAKHPDGAALAGDAEWFMDYWNSDGSFAEMCGNGARVFVRFLLDSGLATPIHGVLPVATRAGLVRARLDGEDIAVEMRRPRLYATSTAALGALTLPGTAVDVGNPHLVCPLPAGLELTGLDLTRAPGFDPTIFPSGVNVEFTADGEPLDGVDGHVLMRVYERGSAETLSCGTGACAVAAVALRDIARETGTIAVDVPGGRLTVTLTDNSCWLSGPALLTATGTLTLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD21</accession>
    <name>F4FD21_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733508.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18755"/>
    <dbReference type="EnsemblBacteria" id="AEB44853">
        <property type="protein sequence ID" value="AEB44853"/>
        <property type="gene ID" value="VAB18032_18755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18755"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375834_0_0_11"/>
    <dbReference type="OMA" id="PYVAYNQ"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="748" mass="80748" checksum="57A5B158DC205054" modified="2011-06-28" version="1">MQHRRSRQHVVDMCRTMLARGYLKATEGNVSVRVPGHRLYAVTPSNYDYDRMRVEDICIVDFDGRHVPDDSGVDLKPSIECGMHANIYRERADVNAIVHTHQPYASALAFLRKPIPALTDEQVRFLGREVAIIDYAPSGTSFLARNVQKKVASGDNAFIIANHGVVAVGTDPDRAVFNMALLEKVSIAYLLALTSEAGKVHTIPTAIREIAFGKLRADEKRIAAQITEAVEPLRVPADESLPSADAVAAETMAAVGSDEVPGAGSTPLGYAISAYPDVDDVMRRLKALTAQPIRGLRHDALLDVLNYFDTKCRASKEITDRAKRRIPGGVQHNLAFNYPFPLAIEKAEGAYLVDRDGNTYIDFLQAGGPTILGSNYGPVNERVAEVVRDCGPVTGLFHEYELKLAEIIHRYMPHIQMYRSLGSGTEAVMAAVRGARAFTGKKVVIKVGGAYHGWSDTMVYGLRVPGTYRMNAKGIPFGATARTREAFPHDLGQLKRKLIENRLRGGTAAVVVEPVGPESGTRPAPRDFNAKVRELCDEFGALLIFDEVVTGFRLGLGGAAGYFGVTPDLTVLGKAVSGGYPMAGGVGGRADVMAVFGSGLDGRSGAHIQVGGTLSANPLSCAAGYFAIEEMARTGAPVIAGRAGDRLTRGLQRLIDSYGLPYVAYNQGSIVHLECSGVMLLDMRNPVKLLKENKARKRLMEQMGAAYTAHGIITLAGSRMYTSMADTDAVIDDALARFDQVFALVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD58</accession>
    <name>F4FD58_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734740.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24950"/>
    <dbReference type="EnsemblBacteria" id="AEB46088">
        <property type="protein sequence ID" value="AEB46088"/>
        <property type="gene ID" value="VAB18032_24950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24950"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_8_3_11"/>
    <dbReference type="OMA" id="NLEMAHF"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="88" mass="9577" checksum="A22CAA912F101CB4" modified="2011-06-28" version="1">MNATTVETGNEQIVSVIVTALEEVLRQELTDVTVETRLFDDLNLDSTSVLALLMTLEDALDTQVDPESLEQAHLESVGSLAAFLAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD86</accession>
    <name>F4FD86_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_25090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734768.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25090"/>
    <dbReference type="EnsemblBacteria" id="AEB46116">
        <property type="protein sequence ID" value="AEB46116"/>
        <property type="gene ID" value="VAB18032_25090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25090"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_11"/>
    <dbReference type="OMA" id="ERKMQFE"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312922" description="Beta-glucosidase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="458"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="497" mass="54566" checksum="AC218800E5DA06F4" modified="2011-06-28" version="1">MSMLTRRHLLRRAALSATAVTPAGAALGAVTTAAGATALAGCQPGEDAEPTEPAASSAARLQFPVNFGWGAATSAYQIEGAAKEDGRGESVWDTFSHTPGRIRNGDTGDVAADHYHRYAEDLDLMRDLGLRSYRFSISWPRIQPDGTGAANQRGIDFYRRLVDGLHERGISPMATLFHWDLPQTLQDAGGWESRDVAYRFADYAATVFEALGDRVPVWLTINEPKTVVQNGYLFGHHAPGRQDPDAAYLVAHHLQLAHGLAVQALRAEGGTGRIGPAFNLHPCYPADDSPAAAEATRLYDGYENRLYLDSALKGSYPEDVLADLGPTSRMVRGIRDGDLEIISSPVDVLAVQYYTPIYVTANGGTVRRWPTSEASWQQIYPDGMYDILTRVTRDYGPIPLTVTENGLPTPDVLAADGTVEDTGRVTFLRDHLAAAHRAVTDGVPLESFHVWSLLDNFEWAEGYDQRWGLIYIDYPTQRRVLKRSAHWYRQVIADNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDB7</accession>
    <name>F4FDB7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">rplA</name>
        <name evidence="11" type="ordered locus">VAB18032_01220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735965.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01220"/>
    <dbReference type="EnsemblBacteria" id="AEB47328">
        <property type="protein sequence ID" value="AEB47328"/>
        <property type="gene ID" value="VAB18032_01220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01220"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_11"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="25338" checksum="CFE640A748143FF3" modified="2011-06-28" version="1">MQRSKSYRKAAEVIDRSKLYTPAEAVKLAKETTNVKFDATVEVAMRLGVDPRKADQMVRGTVNLPHGTGKTARVIVFAAGAKAEEAVAAGADEVGTDELVARIQGGWLDFDAAIATPDQMAKIGRIARILGPRGLMPNPKTGTVTMDVTKAVTDIKGGKITFRVDKHSNLHLIIGKASFSEAQLVDNYAAVLDEVLRAKPSAAKGKYLKKVTLTTTMGPGVPVDPNLVKNLQEGSADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDC7</accession>
    <name>F4FDC7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735974.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47338">
        <property type="protein sequence ID" value="AEB47338"/>
        <property type="gene ID" value="VAB18032_01270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01270"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2884679_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="63" mass="6928" checksum="DDBB28FF3FD9A48F" modified="2011-06-28" version="1">MALVVLSVVEQRLDAVRAVLAGSDVMEVAAGFGVHRSTVHRWVGRYLTEQCADGRSLWETGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDJ3</accession>
    <name>F4FDJ3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH:ubiquinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_06160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731029.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06160"/>
    <dbReference type="EnsemblBacteria" id="AEB42356">
        <property type="protein sequence ID" value="AEB42356"/>
        <property type="gene ID" value="VAB18032_06160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06160"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_0_11"/>
    <dbReference type="OMA" id="LIGFWQH"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="157"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="652" mass="69282" checksum="265586F902A9C361" modified="2011-06-28" version="1">MDEILTYAQAAPAETVSYATADGLLSSVWLLVAIPLLSAAVLLLLGRRADRWGHWLGVAAIGAAFVLGLSYFLGLRGLENKSVELSLWDFIAVGGLHVDFGLLFDPLAGVFVLLITGVGFLIHLYAVEYMAHDPGRRRFFAYFNLFVAAMLLLVLGNNYVMLYFGWEGVGLASYLLISFWYTKPAAATAGKKAFLMNRVGDAGLAIAIFIMFATLGTTQYDEVFNGVGALAGGTVLVLGLLLLLGAAGKSGQFPLQAWLPDAMEGPTPVSALIHAATMVTAGVYLIARSNIIFSANTTLQLVVVSVGALTLVMGAIIGCAKDDIKRVLAWSTVSQIGYMFLGVGLGGAAYALAIVHLLAHGFFKANMFLGAGSVMHGMKDQVDIRRFGGLSKYMKITWLTFGAGWLAIIGMFPFSGYFSKEPIIAAAFEREGWTAWLFGGAAVLGAALTAFYMTRLFVLTFHGPKRWTTDIEHPHESPPLMTIPLILLGIGSLGAGWLLATSVPDWLTATAGLSAGEAHHDAVLPHWAIVALSLGVTVLGALLGWFLFRGGTAIEPQPAGVLVTAARKNLYTDTVNEAVFEKPGIFLTRALVYLDNRGIDGLVNGLAAGVGGGSSRLRRMQTGFVRSYATSILTGALLVVAAFLAVQAGWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDW8</accession>
    <name>F4FDW8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_12675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732317.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12675"/>
    <dbReference type="EnsemblBacteria" id="AEB43649">
        <property type="protein sequence ID" value="AEB43649"/>
        <property type="gene ID" value="VAB18032_12675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12675"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="OMA" id="YGQDDAH"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="222" mass="23931" checksum="713FB0007ABCF76E" modified="2011-06-28" version="1">MRVLVVEDERHLADAIARGLRKRGMAVDVAYDGDSGHEMAFVTRYDVVVLDRDLPGMHGDQICAELASSGALTRVLMLTASGTVADRVEGLQLGADDYLPKPFAFDELVARVQALGRRATPAAPPVLELADLVVDPARRTATRGGAPVELTNKEFGVLCELLKARGAVVSSEELLERVWDANTDPFTTIVRVTVMTLRRKLGDPPLIETVVGAGYRTAEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE19</accession>
    <name>F4FE19_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NMT1/THI5 like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733543.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18930"/>
    <dbReference type="EnsemblBacteria" id="AEB44888">
        <property type="protein sequence ID" value="AEB44888"/>
        <property type="gene ID" value="VAB18032_18930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18930"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_5_1_11"/>
    <dbReference type="OMA" id="TSLMIAQ"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313833" evidence="2">
        <location>
            <begin position="43"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="54"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="35123" checksum="68A77807B2CBEE1A" modified="2011-06-28" version="1">MFRTTRITGHPSLPTTFRRGAAGLLAAALLGTAVTGCGSDQATDAAGTDDGLTTITLASSPLGHLAPIYLAEDKGIFARHGLKVEVDTETSDLTSVPSVLAGKVDFATGDLTTLIVARTQGLDVKAVVPASASTGKAGADYGALVVAADSGITSPKQLEGKTVAVNILTNIAAAAAREAVRADGGDSESLKLVEIPFPQVPAAISEGRVAGAWVVEPFLSAAKAQGAVPIGWGFTDLAEDLTVSAWYTSGALVTRKPEVVTAFRTAIREAYAYAREHEDEVRAKIPTFTQITPEVAAKITITGWRDEVSRQAAEKLAGYARRDGLINTTPDLDELILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE47</accession>
    <name>F4FE47_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xylosidase/arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19070"/>
    <dbReference type="EnsemblBacteria" id="AEB44916">
        <property type="protein sequence ID" value="AEB44916"/>
        <property type="gene ID" value="VAB18032_19070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19070"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_0_11"/>
    <dbReference type="OMA" id="WSDPVWI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="7">
        <location>
            <begin position="308"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="518" mass="56434" checksum="D7DBA4E5B4F97564" modified="2011-06-28" version="1">MTDSATFGNPVVPGFHPDPSVCRVGEDYYLVCSSFEYFPGVPIFHSRDLVNWRQIGNVLDRPSQLELPPDTHASAGIYAPTIRHHDGRFYLVTTNVTTGRHLLVTATDPAGPWSEPVHLDVPHIDPSLTWDDNGDCWLTVSGVESYRIDPETGTVLEGPVPMWSGTGGQYPEAPHLYRIGDWWYLLVSEGGTHTGHAVSIARSRSIRGPFEPGPVNPFLTHRSTDRLVQATGHADLVQATDGSWWMVLLGIRAKGQWPPYHVLGRETFLVPVRWVDGWPVVDPVEETMTAPAGSPPALAAVRDPSAYRDDFDADALAPEWISLRERPKDSWSLTERPGWLTLHAAGTTLDRSGATLVARRQQHHDCRAGVHVDPGTGRAGLTLRIDEAHHYDIEVADGLVQVIGRVGPFRQVFGELSVPAGPVTLTIATRTDDLLPPTVTAADQVTAPGAPFGVRPAACDTVSFEVLTDGGPVVLAELDGRYLSTEVAAGFTGRVFGLYVTEGSAAFDWFDYRPSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEE3</accession>
    <name>F4FEE3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734861.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25555"/>
    <dbReference type="EnsemblBacteria" id="AEB46209">
        <property type="protein sequence ID" value="AEB46209"/>
        <property type="gene ID" value="VAB18032_25555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25555"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_8_1_11"/>
    <dbReference type="OMA" id="YFNQCIS"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="42365" checksum="924EE72BEBD24AB7" modified="2011-06-28" version="1">MTHRIVVLGAGYAGATVAGRLARRLHPDQTEITVVDASADFVERVRLHEYAAGSELKRRPLRDVYAGTGVRVRLARVTGVDVEARTVTLTGADKIDYDTLVYALGSASADHGVPGVAEHAYDVGSARSALRLRERLTDLGAGGTVLVVGGGLTGLEAATEIAEARPDLAVAIATRGGLGDWLDARAGRYLREVCDRLGITVHERTDVSRVEANGVVTGTGEVIAAEVTVWSAGFAVSSLAATTALQVAPTGQIVVDATMRSVSHPDVYAVGDAALAGGPGGKPLRMSCATGIPTGWQAADAIVARLTGRPVRRIPIRYFNQCISLGRRDGIIQTVTADDRAKATHLRGRLAARYKELVCRGAAWAVFHPTLLVPFRRRRIISPAATAQRHARSVSSDVGGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEG2</accession>
    <name>F4FEG2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01600"/>
    <dbReference type="EnsemblBacteria" id="AEB47404">
        <property type="protein sequence ID" value="AEB47404"/>
        <property type="gene ID" value="VAB18032_01600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01600"/>
    <dbReference type="HOGENOM" id="CLU_3067417_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="53" mass="5977" checksum="22162B16A538F00E" modified="2011-06-28" version="1">MLPEIGTPLAIAFVVAAVARSAVWLYIAHRARREDLPKIAESFSGSRRTIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEM2</accession>
    <name>F4FEM2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ordered locus">VAB18032_01900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736098.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01900"/>
    <dbReference type="EnsemblBacteria" id="AEB47464">
        <property type="protein sequence ID" value="AEB47464"/>
        <property type="gene ID" value="VAB18032_01900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01900"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_1_11"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="29"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="28704" checksum="8DC7C5F315CE0B33" modified="2011-06-28" version="1">MTASEGPTVGTLVLLRHGESDWNAKNLFTGWVDVDLTEKGENEARRGGELLREHNLLPDVVHTSLLRRAIRTSELALNAADRHWIAVRRSWRLNERHYGALQGKDKKQTLEEYGEEQFMLWRRSYDTPPPPIADDDEWSQVGDPRYALLPTELMPRTECLKDVVERMLPYWYDSIVPDILAGRTVLVAAHGNSLRALVKHLDQISDEAIAKLNIPTGIPLRYDLDPLLRPQTLGGTYLDPEAAKAAAAAVANQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEQ2</accession>
    <name>F4FEQ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731119.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06610"/>
    <dbReference type="EnsemblBacteria" id="AEB42446">
        <property type="protein sequence ID" value="AEB42446"/>
        <property type="gene ID" value="VAB18032_06610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06610"/>
    <dbReference type="eggNOG" id="ENOG5033HR0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135691_0_0_11"/>
    <dbReference type="OMA" id="AVVCLPM"/>
    <dbReference type="OrthoDB" id="1908968at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="18710" checksum="AC65CA708A384884" modified="2011-06-28" version="1">MEFLRLLLLSLALAAVVCVPALIALVLCADEVLDRVTCRFAEWRERGRERRLITRLNQAVAVEDLADPDALDALDRPDRRPLEQLAADLRCLRRDRVGGAAVVWHSSVLDAYDDRLRLACRALGIPEHLAELTGIDQQIERVRIEGELDAAGLRLPASRPGQHQRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEW1</accession>
    <name>F4FEW1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal translocating P-type atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_06905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731178.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06905"/>
    <dbReference type="EnsemblBacteria" id="AEB42505">
        <property type="protein sequence ID" value="AEB42505"/>
        <property type="gene ID" value="VAB18032_06905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06905"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_11_2_11"/>
    <dbReference type="OMA" id="MALEPMG"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="707" mass="74122" checksum="9D1DE72F133C11F2" modified="2011-06-28" version="1">MTRDSEHGGHAGQHGGHDKHAGHGGHDKHAGHDPEAFRRKFWLSLALTVPIVVTSHMVMDWFGYELDFPGIDLVGPVLGTVVFAYGGWPFLQGAVREIRDRAPGMMLLIAMAISVAYLASLATALGAFDLDFWWELAALVTIMLLGHWQEMKAIGQAQGALSALAALLPDDAERLTHDGRAERVSVADLRVGDTVLVRPGARVPADGQVLDGQAEMDESMITGESRPVARATGDRVVAGTVATDASLRVRVDAVGDDTALAGIQRLVAQAQQSSGRAQVLADRFAAWLFYIATATALVTLLVWTVLGNLGEAVVRTITVLVIACPHALGLAIPLVIALSTAVAAKGGILVKDRLALERMRTVDTVLFDKTGTLTRGAHTVTAIAATADPSTQNSNGQETAGQREVLAIAAAVEADSEHPLARAIVAAAEAQGLRRTATGFQALAGRGVRAEVDGVSYAVGGPALLREFGVTVPDALTRRQEQWSRRGAAVLHLLRLSANQKSDGRAEVLGALALEDEVRPEARQAIADLRGQGIRKIVMITGDARPVAEAVAADLGFRAGEDEVFAEVLPAEKDDAVVDLQRRGLRVAMVGDGVNDAPALARANVGIAIGAGTDVAIESAGVVLASSDPRGVTGVIRLSRAAYRKMVQNLAWAAGYNVVALPLAAGVLAWAGVALSPAVAAVLMSASTIVVALNAQLLRRVRLRPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF52</accession>
    <name>F4FF52_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19275"/>
    <dbReference type="EnsemblBacteria" id="AEB44957">
        <property type="protein sequence ID" value="AEB44957"/>
        <property type="gene ID" value="VAB18032_19275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19275"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_0_11"/>
    <dbReference type="OMA" id="QSAMSQH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="14530" checksum="CF34725751D7E7E0" modified="2011-06-28" version="1">MVDKVAAAIADPVRRRILELLRERRLTAGRIAEHFEISRPAVSRHLRVLRESGLVRDTLVGRERRYELDATRFDELNRWLSQFAQPERWERRFDALETEVHRTRRERRTGRSPNSREERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFB7</accession>
    <name>F4FFB7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_19600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19600"/>
    <dbReference type="EnsemblBacteria" id="AEB45022">
        <property type="protein sequence ID" value="AEB45022"/>
        <property type="gene ID" value="VAB18032_19600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19600"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032986_0_0_11"/>
    <dbReference type="OMA" id="EGPNAWT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="278"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="649" mass="71555" checksum="CF72A0D0E46B4E5F" modified="2011-06-28" version="1">MAVFMKARELRPLGGNVGVVTDTRLSRDVAERPPGGGPVESTAVRPSPARRPDRRQLNISARIAYASCGASAGTLVAPRHPQAAVEFRSVLSPAARLVLTLLVLVNSAAGLLLVGWLLLPQHVPGSGVTGLGDWQTAVARLGFCVIVGVELIRLAQNMVVWVFAYHAKDPIPVDPPVGLRVALLTTIVPSKEPIDVAERTLRRMRQIVYCGQVDVWILDEGDDPAVKEMAARLGVRHFSRKGRPEYNQPDGEFRTRTKSGNHNAWRAEHEHHYDVVANVDPDHVPLANFLERTLGYFRDPDVAFVVTPQVYGNMHQNMVAHGASVQQYLYNGLIARGGNGLDAPLLTGTGHLYRPSAWRSIGGYQDSIIEDHLTSIRIHAAVNPQTGNQWKGVYTPDVVAIGEGPTSWADYFNQQKRWAAGICEILVRPELRAPRELRSRRRWHYRLLQFYYPSVAVSLLLGNFATAAYLLTGVSAARVDIAVWSVLWGATICTWFVLWLWLRRFNIAPHEREEIGLVGMALALFAGPIYVAAAVGALLRRKLGFVVTAKGRLRTTESLNTFRLHLCWAAFAAGLLAVSFVLEHGRTPLRVWPLLTLLTGLGPPLIACGSALLAWRSRRASPTGRHAVRHRRVRATAPVVASREVPWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFL3</accession>
    <name>F4FFL3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonyl/alanyl tRNA synthetase SAD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_02030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736124.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02030"/>
    <dbReference type="EnsemblBacteria" id="AEB47490">
        <property type="protein sequence ID" value="AEB47490"/>
        <property type="gene ID" value="VAB18032_02030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02030"/>
    <dbReference type="eggNOG" id="COG2872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_3_2_11"/>
    <dbReference type="OMA" id="LMRLHTA"/>
    <dbReference type="OrthoDB" id="783542at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="245" mass="26640" checksum="9A0DC63631648A81" modified="2011-06-28" version="1">MGVTHHGRTHRLDLADPSLREWQCTVLHSDPEQGIVLDRSAFYPGGGGQPPDHGVLLWQGVQTRVVGTRKADDLWLIPAEGDPLPPTGTTVTGAVEDDRRTRLMRTHSGLHVLCGVVFRDFGALVTGGNMEPGEARMDFNLPEVPSDFKSRIEELVNAEVAADRAVATRVLPRVEALALPDIIRTQSNLIPPDEAEVRIVDIVGLDVQADGGTHVASTAQIGKVRVVKVESKGRANRRVRIRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFS5</accession>
    <name>F4FFS5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736185.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02340"/>
    <dbReference type="EnsemblBacteria" id="AEB47552">
        <property type="protein sequence ID" value="AEB47552"/>
        <property type="gene ID" value="VAB18032_02340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02340"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_2_0_11"/>
    <dbReference type="OMA" id="EQHDIVA"/>
    <dbReference type="OrthoDB" id="1635544at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="158" mass="16502" checksum="D78B5ADA64B6B65E" modified="2011-06-28" version="1">MTHDAAGEQTGPEPRIRPYLRASSPVGDAEGAPAAFGAEPETAEPTGLRPFVLTAGRVAGADPTIGLETQVTVRSDAEAWHLSAARLAPELQAIVALCSEPISVAEISAKTRLHFGVTRVLVGDLRAAGHLDVHVTDTDDALDPDVILRVIDGLRAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFT1</accession>
    <name>F4FFT1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42511">
        <property type="protein sequence ID" value="AEB42511"/>
        <property type="gene ID" value="VAB18032_06935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06935"/>
    <dbReference type="eggNOG" id="ENOG5030N64">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109716_0_0_11"/>
    <dbReference type="OMA" id="LIGMRIN"/>
    <dbReference type="OrthoDB" id="1681539at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="DUF4188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="177" mass="20148" checksum="6F6267ED88BB54AD" modified="2011-06-28" version="1">MTAEIEGDFAVFITGMRINRYWKIHKWYPNFRDMRKILMALFSDPENGALCAHHAWTRRGPILIGYFRSVEQLERFANDPQQPHAEVWARYFKRMKNNGDVGVWHETFVVRSGEYEAVYDYMPSPTGLAMGTSHVPVERRGDLAVDRRATGARLAKERTAAQTAGDGKAAAGRTPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFZ6</accession>
    <name>F4FFZ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aryldialkylphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731249.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07260"/>
    <dbReference type="EnsemblBacteria" id="AEB42576">
        <property type="protein sequence ID" value="AEB42576"/>
        <property type="gene ID" value="VAB18032_07260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07260"/>
    <dbReference type="eggNOG" id="COG1735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054760_1_1_11"/>
    <dbReference type="OMA" id="CHMNPSH"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="35448" checksum="9DBD02A74C73A11C" modified="2011-06-28" version="1">MGYVQTVLGPVPPESLGRVLSHEHLGALVPGPWLAGGAGDDRADLAVDAVRGLPELGFGTVVDLSPYEVVGHDVTLLREVAQRTGLHIVAGSAIYLEPYSPSWALTAGVDEMRERFIADATIGVGDTGIKVGIFGEQATGLNEITPHEEKCLRAAARAHVATGLAVNTHTTHGTMALEQVEILREEKADLSRIVIGHLDINPDPDYLRAVLATGVNIAFDTIGKQFWDFVLAPLPENPPEGEFAKRAYHRPDRARLEMLAGLVRDGYADRILLSMDLTGAEAYLNPRTHGRLGYSYLGQEIVPGLARLGVPPEAIDQMLVTNPARLLTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG02</accession>
    <name>F4FG02_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_07290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731255.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07290"/>
    <dbReference type="EnsemblBacteria" id="AEB42582">
        <property type="protein sequence ID" value="AEB42582"/>
        <property type="gene ID" value="VAB18032_07290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07290"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_0_11"/>
    <dbReference type="OMA" id="RQSYGKL"/>
    <dbReference type="OrthoDB" id="1469807at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="425" mass="46567" checksum="0E28824E42C98511" modified="2011-06-28" version="1">MTTSEGRAATAVAAGTEGRAAAAVAARDSYGRLLALLSTTTSDIVWAEDALADAFERALRSWPEQGVPNNPTGWLLTVARNRLRDHWKSAQWQRSVPLDVERDTPVHLDTLDPDAIPDRRLELMLVCAHPAIERAARTPLMLNTVLGFTAEQVGRAFSTPTSTMATRLVRAKRRIKATGIPFRIPDRSDLPDRMAAVLEAIYGAYVIDWATTGPQARPVPTEALHLAEVLTTLVPDDPEAHGLAALVQLSAARLPARLDEHGRFVPLAEQDPTRWNELLIHRAHQHLRTAHARRHLGRFQLEAAVQAVHCARRHTGTTDWPALLDLHRALHTLAPSLGGAVALAVATAEVEGPAAGLTRLDELPNDRARRFQPAKAARAHLLERLGRHTEAAAAYDSAIALTHDPAERGYLEHRRARLCPAHDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG06</accession>
    <name>F4FG06_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731259.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07310"/>
    <dbReference type="EnsemblBacteria" id="AEB42586">
        <property type="protein sequence ID" value="AEB42586"/>
        <property type="gene ID" value="VAB18032_07310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07310"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103761_0_0_11"/>
    <dbReference type="OMA" id="HWYWRPG"/>
    <dbReference type="OrthoDB" id="1251384at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="221" mass="25019" checksum="0A341FF69D332977" modified="2011-06-28" version="1">MSSRELASLHERWTAYQNLPELTNHWYWRPGWRADRHFYTWHLTFNNQPKLHQLVTELQHDLALPGLDLVPIDGLHLTMQGLGFTDDVPDTDIEAIVAEAQQRCAGLPPLELSLGPVDPDAEGIGLLVRPWHRVEHLRAVIRDAIGAVWPIVPEPAQGFRPHVTIAYSGAPVPTEPIRARLAELREHPPASVTIRQMPLIALRRENRAYRWKTIATVPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG11</accession>
    <name>F4FG11_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_13205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13205"/>
    <dbReference type="EnsemblBacteria" id="AEB43755">
        <property type="protein sequence ID" value="AEB43755"/>
        <property type="gene ID" value="VAB18032_13205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13205"/>
    <dbReference type="eggNOG" id="COG3973">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010312_3_1_11"/>
    <dbReference type="OMA" id="ASRTYEF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="188"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="209"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="762" mass="83426" checksum="42660B89E5D14A1F" modified="2011-06-28" version="1">MSRHSDGSPSDDEIGREQEYVSMLYQRLDGLREQASQRLTEELRVTGGTLQARSQRDSAVRMYADQVEQFSAVENGLCFGRLDTDDGARHYIGRIGIFDTDGDYDPLLMDWRAPAARAFYLATAANPQGIRRRRHLRTRQRKVIGLNDEVLDLNTASPTAHEELTGEASLLAALNAGRTGRMRDIVETIQAEQDRIIRADLPGVLVVQGGPGTGKTAVALHRAAYLLYTYRRELSTRGVLLVGPNLTFLHYISQVLPALAETGVLLRTQADLFPGVNARRAEPATTAAVKGRPVMVEVLTNAVRDRQRVPDEPLEIELPQREILVLDPATVQAARDRARRSGRPHNLARAVFDIEIIHALADQVAERIGADPLGGENLLEEADLAEIRRELREEPEVRATLDELWPVLTPQRLLADLYADTDRIATAAPMLTADERAALHREPGGWTPADVPLLDEAAELLGEDDRAAAARRERLRALQREYAEGVLEIARGSRSIDVEDEADGGEILGVTDLLDADQLLERQEEADRLTTAQRAAADRSWAFGHVIIDEAQELSPMAWRLLMRRCPSRSMTIVGDVAQTGALAGTPSWAQALAPYVADRWRLTELTVSYRTPAEIMAVAAEVLAEIDPTLQPPRAVRSSGRTPVARRAPAERLAAELVEIVTAEAAALTDGRLGVIVPAGRVDDLGATVTTALPEATVGEQPDLESRVVILTVAEAKGLEFDSVIVVDPDQIVAESPRGRSDLYVALTRATQHLTTLTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG57</accession>
    <name>F4FG57_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_13445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urea transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13445"/>
    <dbReference type="EnsemblBacteria" id="AEB43801">
        <property type="protein sequence ID" value="AEB43801"/>
        <property type="gene ID" value="VAB18032_13445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13445"/>
    <dbReference type="eggNOG" id="COG4413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047509_0_1_11"/>
    <dbReference type="OMA" id="CPDWATA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017807">
        <property type="entry name" value="Urea_transporter_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464">
        <property type="entry name" value="PTHR10464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016502">
        <property type="entry name" value="Urea_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03441">
        <property type="entry name" value="urea_trans_yut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="site" description="Important for channel permeability" evidence="8">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="350" mass="37660" checksum="6C212BC0BBCB0C8F" modified="2011-06-28" version="1">MALIGQETDVTAIARRWDGLADHNPLVQFIDACLRGPAQVVFQNNPLTGVVILLAVAWGAFDSGHPRIFGGGVLGLVVGTATALALQVDRASWRKGLFGFSPFLTGIAVPTFLDQRPLMWLYLVLGAAGTTVVTLALNAVFKRWGLTAFTFPFVLTTWVLLLAAYQFERFTVLTQLTPKFPGEGTLTGGHFNWDLVPIFLRGISQVFLINSWVSGLLIIIALLINSRWSAVFAIVGAVGATLLALWFGADGTSLDKGLFGFNAVLTAIAVGAVLHRPGLLVTGYTLFGIALTLFIQMAMASVLTPLGIPVLTGPFNVATWLLLLPDRHFAPVPNHERVKETVVSSVRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG69</accession>
    <name>F4FG69_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">VAB18032_13505</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732480.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13505"/>
    <dbReference type="EnsemblBacteria" id="AEB43813">
        <property type="protein sequence ID" value="AEB43813"/>
        <property type="gene ID" value="VAB18032_13505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13505"/>
    <dbReference type="eggNOG" id="COG4770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_239133_0_0_11"/>
    <dbReference type="OMA" id="NTVYPYE"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="14">
        <location>
            <begin position="1"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="125"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="572"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="15">
        <location>
            <begin position="1538"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1505"/>
            <end position="1524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB43813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1820" mass="196757" checksum="AA7BEA2AD76ABCA8" modified="2011-06-28" version="1">MFSRIAIVNRGEAAMRLIHAARELAAQTGTRIETVALYTDVDRTATFVREADLAYELGPASARPYLNLATLERALVATGADAAWVGWGFVAEDPAFAELCEKIGVTFIGPSPEAMRQLGDKIGAKLLAEQVGVPVAPWSRGAVENLNAARAAAAEIGYPLMLKATAGGGGRGIRVITSEAELADAYERTSQEAARAFGSGVVFLERLVTGARHVEVQVIADGQGTAWALGVRDCSVQRRNQKIIEESASPVLSAEQAAELKASAERLALAVGYRGAATVEFLYHPGDRLFAFLEVNTRLQVEHPITESTTGFDLVKAQLWVAAGRRLEGEAPVERGHAIEARLNAEDPDRDFAPSPGRVARLDLPAGPGIRVDTGISEGDTIPADFDSMIAKIIAYGRDRDEALGRLRRAMAETTVIIEGGATNKSFVLDLLDQPEVIDASADTGWIDRVRGAGGLVGHRHSAVALAAAAIEAYEEEERGERHRLLATAAGGRPQVQHVGGRPLDLKLRGVGYRMRVARTGAHRFRVGIEAGGEVRTADVELDRFDRHTGQIVVNGAQHRLLTATHGPIHLVEVDGVTHRVSRDEGGVLRAPMPALVVATPLAVGAEVEAGAPVLVLEAMKMETVLRAPFRARLKECAVSVGSQVEAGAPLLRLDPIADDDAEPGTDPAGPTVELDLPTAPGQVPALARARRGQEDLRGLLLGFDVDPHNDRRVLDDYLVARQEATEDGHRPLAEELDLLNVFADLAELSRNRPTGEDGGSAHVHSDREFFHTYLQSLDVERAGLPATFQGKLARALGHYGVTELDRCGDLEAAVFRIFLAQQRASADAAVVTALLRAWLQEPPPEESLREPIGLALERLLAATQVRFPVIADLARGVVFAWFAQPLLRRNRARVYAEVRKHLRHLDAHPDAPDRADRIAAMVRSTEPLVRLLGQRLLRDHLDNTVMLEVLTRRYYGNKQLIGVRAHEVGGCTFVVAERADSSLVSAAVGFDALGDALRGLAELAADEEAVNADIYLAWENQPEDFDAMAAALLAVINAQPLPPQVRRLTATVAGSGGAVMHHHFTFRPASTGMAEERLIRGLHPYIAQRMQLERLRKFDLTRLPSADEEVYLFQCVARENPSDDRLVAFAQVRDLTELRDHDGRLVALPTTEDAVAACLDSIRRARALQPSKTRFHTNRIVIYVWPPSGLTRAEMEMIAGRVRPTTAGAGLEEILFIARQRDRATGQLTKVGIRITFDATGGAELTVGEPPIEPIEPLDDYRLKVLRASSRNTVYPYELTRLLGDFVEYDLDDTHTLVPVDRPKGRNSAAIVAGVVSTKTARHPQGISRVILLGDPTKALGALSEPECRRVIAALDLAERMQVPLEWYALSAGARISMTSGTENMDWVAAALKRIVEFTQDGGEINIVVAGINVGAQPYWNAEATMLMHTKGVLVMTPDSAMVLTGKQSLDFSGGVSAEDNFGIGGYDRVMGPNGQAQYWAPNLPAARDVLMAHYDHTYVVPGESAPRRTETTDPVDRDISGFPHSVAGSDFSTVGEIFSAEANPDRKKPFDIRTVMRALSDQDHPVLERWAGMADAETAVVQDVHLGGIPVCLLGIESRSVPRHGFPPTDGPDTYTAGTLFPRSSKKAARAINAASGNRPLVVLANLSGFDGSPESMRKLQLEYGAEIGRAIVNFRGPIVFCVISRYHGGAFVVFSKALNPNMTVLALEGSFASVLGGAPAAAVVFSRDVDARTAADARVRDMQARVAAAAGTDRAELTAELDELRSSVRAEKLGEVAAEFDRVHNIHRAVEVGSVDAVIRAAELRPRIIEAIEAHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGB1</accession>
    <name>F4FGB1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-carboxy-cis,cis-muconate cycloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19735"/>
    <dbReference type="EnsemblBacteria" id="AEB45049">
        <property type="protein sequence ID" value="AEB45049"/>
        <property type="gene ID" value="VAB18032_19735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19735"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_3_3_11"/>
    <dbReference type="OMA" id="HTQRDEW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047472">
        <property type="term" value="F:3-carboxy-cis,cis-muconate cycloisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012789">
        <property type="entry name" value="Protocat_PcaB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02426">
        <property type="entry name" value="protocat_pcaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="1">
        <location>
            <begin position="355"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="437" mass="44298" checksum="ED4A4E41CAA21092" modified="2011-06-28" version="1">MLLRGLSGAVDVDAELDDSHLLQALLDAEAALARAGADAGLLPGPVADEIARHCHADRYDPAALGTAADAAGNPVVPLVRDLTAAVAPPARAWVHHGATSQDILDSALALVVARAAVPLLRHLDAATDAAVGLARAHRDTVMVARTLGQQAAPTTFGLKAAGWLLGLHDARTRLAQARTALPAQLGGAVGTLAGYGPSGLVVADRFAAHLGLAAGPLPWHTRRQPVLDLAAALGGLLAATGKVALDVGLLAQTEVGEVAEGGPGRGGSSAMPHKRNPVDSVLVTAAARRGPGLVGTLFAAAGQEHERATGGWHAEWEPLLDLLHLAGGAAARTARMLGNLRVHPQRMRANLDATGGLLLAEAVAARLAPALGRAAAHDLVARAATAASFRDALLADPDVRAHLSVADVDAALDPAGWLGSAATLVDRALDSYERGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGB3</accession>
    <name>F4FGB3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoadipate enol-lactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19745"/>
    <dbReference type="EnsemblBacteria" id="AEB45051">
        <property type="protein sequence ID" value="AEB45051"/>
        <property type="gene ID" value="VAB18032_19745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19745"/>
    <dbReference type="eggNOG" id="COG0599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1792151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AhpD-like"/>
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        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012788">
        <property type="entry name" value="Decarb_PcaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="decarb_PcaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="14292" checksum="9AC9A16A9CDD37A8" modified="2011-06-28" version="1">MNDKQRHDAGMAVRRQVLGDAHVDRAVANTDEFTADFQDLITRYAWGEIWTRDGLDRRTRSCITLAVLATLHHDEELAMHVRAALRNGLTPQEVREVLLQVAVYAGVPAANRAFKVAQETLRQEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGF6</accession>
    <name>F4FGF6_MICM1</name>
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        <submittedName>
            <fullName evidence="8">Ion transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19960"/>
    <dbReference type="EnsemblBacteria" id="AEB45094">
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        <property type="gene ID" value="VAB18032_19960"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502Z7ZD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="IRMIPAI"/>
    <dbReference type="OrthoDB" id="1280139at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="PTHR10037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="7">
        <location>
            <begin position="27"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="33758" checksum="3E8BF59D3A591898" modified="2011-06-28" version="1">MPAQRSGPVDPSRTRLADACARISHSRPFELAIVAVILANGAVLGLETYPDLGAAGTALHAVEWVFRVIFVIEIAIRLLAYGRRPQDFFRQGWNVFDFLVIAAIFVPVLHGDSALLRVVRVLRMVRLVRFSPGLRTIVAALWRSLPGIGGFFALAVVTLYVYGMAGWLIFGKVYPEEYGDIGRSLLTLFVLLSLETLPDLIEQGMEVSPWTVLYYASFVVITVNLLLNILIAVFVNSMEEARRLEMTEGLAPGYDSDGDGVPDEVDRIAISQRLDDLRTLIVELERELRIDRDDGRGRRVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGR5</accession>
    <name>F4FGR5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">cysS</name>
        <name evidence="14" type="ordered locus">VAB18032_02455</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736208.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02455"/>
    <dbReference type="EnsemblBacteria" id="AEB47575">
        <property type="protein sequence ID" value="AEB47575"/>
        <property type="gene ID" value="VAB18032_02455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02455"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_11"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="13">
        <location>
            <begin position="346"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB47575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="471" mass="51895" checksum="B9F91633A69FD7D9" modified="2011-06-28" version="1">MTLRLYDTATRSVRDFVPREAGKVGVYLCGLTLQAPPHIGHLRSGVNYDVLRRWLLAAGFEVTFIRNVTDIDDKILIKAQEQERPFWSIAYANELKLAEAYRALNVLPPTYEPRATGHIPEMHQLIAQLIERGHAYPATDDSGDVYFDVRSWPAYGALSNQSPDEMQSAADAPERGKRDPRDFALWKGVKPGEPADAYWPSPWGLGRPGWHIECSAMCWRYLGAEFDIHGGGLDLIFPHHENELAQSQAADLPFARYWVHHGLLGIGGTKMGKSLGNALDLAYVAGLGVRPVELRYYYVAAHYRSRIDYSEEALREAAVAYRRIEGFVQRSVERVGVGQLGEVPAAFAAAMDDDLNTSAALAVLHDVLRDGNNALAGGDDVTVRTALASVRAMLDILGVDPLDPAWTGGARASDLRGVVDSLVALALEQRAQARVRKDWAAADALRDQLKRAGVVVEDTPQGPRWTIGEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH92</accession>
    <name>F4FH92_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13790"/>
    <dbReference type="EnsemblBacteria" id="AEB43870">
        <property type="protein sequence ID" value="AEB43870"/>
        <property type="gene ID" value="VAB18032_13790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13790"/>
    <dbReference type="eggNOG" id="ENOG5033FRI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137437_0_0_11"/>
    <dbReference type="OMA" id="WTRAECL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307735" evidence="2">
        <location>
            <begin position="27"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="164" mass="18276" checksum="8B40D09DD17E16A7" modified="2011-06-28" version="1">MPSVVSLLAVAHRHLRLATPAESADATTRSYLDDGRCLGWYAPPVPRWRVAIDAERVGAPVPTALARRFGTGEFWARWTRAECLAKLTDVPMAIWWQRHGLEVPPRIDWLWRTLTLADLVVTVAFVATDRPRDTADVPLPDGDPGSRRPRGDADHPAAAAHYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHG2</accession>
    <name>F4FHG2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733789.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20170"/>
    <dbReference type="EnsemblBacteria" id="AEB45134">
        <property type="protein sequence ID" value="AEB45134"/>
        <property type="gene ID" value="VAB18032_20170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20170"/>
    <dbReference type="eggNOG" id="COG2263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047561_0_0_11"/>
    <dbReference type="OMA" id="LPGPQHW"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="53"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="30074" checksum="DBAFBBAF6023A014" modified="2011-06-28" version="1">MTEQQAVQDAPIELPPDFAQWLALREPADVAARATDLVDTVRATLTGDTPYVVHDLGAGTGSLGRWLAPLLPGPQHWVLYDQDPDLLARARAGMPTVAAGGAPVTVQTRRGDLTRLTATDLAGAALVTASALLDMLTAAEIERLVAACAGAGCPALFLISVTGTVRLTPADPLDVEIADAFNAHQRRTVGGRHLLGPGAVDACAAAFTRHGMTVRTRPSPWRLGPEQAALTAQWFTGWLDAACEQRPELVDLTHEYAKRRRNEANAGRLGVLVDHTDLLAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHH1</accession>
    <name>F4FHH1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta fold family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733798.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20215"/>
    <dbReference type="EnsemblBacteria" id="AEB45143">
        <property type="protein sequence ID" value="AEB45143"/>
        <property type="gene ID" value="VAB18032_20215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20215"/>
    <dbReference type="eggNOG" id="COG3545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1531018_0_0_11"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010662">
        <property type="entry name" value="Hydrolase_RBBP9/YdeN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06821">
        <property type="entry name" value="Ser_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="178" mass="19732" checksum="4580D35051E2B1A4" modified="2011-06-28" version="1">MGRNAIIFHGTGGSPDNCWYPWLAGRLATRGYAVEVPHHPGINIEPITTFLPKALGSHTFDADTVLVGHSGGAALLLALLEHLDVTVAQAILVAGYCTPPNTEEEPVLQPSYDWAAIREHVRDIYFVNSRTDPYGCDDRQGRAMFERLGGTQIVRDDGHFGDYDQPYERFDLLDRLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHH6</accession>
    <name>F4FHH6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_20240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20240"/>
    <dbReference type="EnsemblBacteria" id="AEB45148">
        <property type="protein sequence ID" value="AEB45148"/>
        <property type="gene ID" value="VAB18032_20240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20240"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_0_11"/>
    <dbReference type="OMA" id="MMSSWKL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307741" evidence="8">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="31171" checksum="A5A664BE32CC7D2A" modified="2011-06-28" version="1">MVVLSIAVGAKPIPLTQVWAALTDPGAVDYAVVHDMRLPRTLLGLLAGLALGTAGAAMQALTRNPLADPGLLGINAGAAAAIATASLLFGVGGGTGQVWFALGGAAAVTVGVYAVGGGRTATPARLALAGAALNAALYSYVSAVMLLDSAGLQRLRFWTVGSLASADDATVRRVLPFIAVGLVAALAAARPLNALALGDDTARALGARPAWIRAAVIAAITLLCGAATAACGPIVFVGLLVPHLVRTLTGPDLRWLLPYCALLAPVLLLGADVLGRVLGRPGELQVGLVTAVLGGPLFLWLVTRTRTARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHH7</accession>
    <name>F4FHH7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733804.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20245"/>
    <dbReference type="EnsemblBacteria" id="AEB45149">
        <property type="protein sequence ID" value="AEB45149"/>
        <property type="gene ID" value="VAB18032_20245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20245"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062437_0_0_11"/>
    <dbReference type="OMA" id="WYVPDES"/>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309345" evidence="2">
        <location>
            <begin position="36"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="65"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="36103" checksum="A27223DE41181299" modified="2011-06-28" version="1">MPDPVSARRLSRRGLLAAGGAAALAAVLVGCGRDEADKASTSNGSGSWSFTDDRPEAVTAPARPARVVAFTGSAAALVDFGLGREVVGVFGETKKADGSKEPQAGDLDVESVEILGNVWGEFSVEKYAALRPELLVTHMYDPGAYWYVPDESKDKILPLAPVVTITTARVPMTKPIERYAALAQSLGADLSAPKVTDAKARFEAAAEAVRQAVKANPGIKVLAASGSPDLFYVSNPKVSTDLMYFAELGVDIVVPTKLESGDYFEALSWENAGKFPADLILLDNRSTALQPADLAAKPTWTQLPAVQAGQVTGWDAVPRFSYAGAAPLLEDLAKAIQGAKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHI0</accession>
    <name>F4FHI0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733807.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20260"/>
    <dbReference type="EnsemblBacteria" id="AEB45152">
        <property type="protein sequence ID" value="AEB45152"/>
        <property type="gene ID" value="VAB18032_20260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20260"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039848_5_1_11"/>
    <dbReference type="OMA" id="DVGMHFL"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlcB" evidence="5">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="20997" checksum="112F1C283A5782E5" modified="2011-06-28" version="1">MSATVHIRTDPVLGEFALRTLDVAADAPLLHGWVTHPKAAFWLMQDADLAAVVQEYQRIAAHPHHDAFLGLWRGEPAFLAERYDPAQVELVGLYDAQPGDVGMHFLCAPAETPVHGFTRAVITTVMSWLFADPDTVRVVVEPDVRNTAVHALNAAVGFEVIGPITKPEKQALLSICTRERFLAATRDQGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHI8</accession>
    <name>F4FHI8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733815.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20300"/>
    <dbReference type="EnsemblBacteria" id="AEB45160">
        <property type="protein sequence ID" value="AEB45160"/>
        <property type="gene ID" value="VAB18032_20300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20300"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060076_0_0_11"/>
    <dbReference type="OMA" id="IAMNGVT"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="152"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="383" mass="42594" checksum="A66C084DB3AA7385" modified="2011-06-28" version="1">MTRRSIGIIVNGVTGRMGYRQHLVRSLLAIRDAGGLPLADGTTVWPHLVLVGRSETKLREIAQRHGLDDWTTDLAAALARDDVEIYFDAQVTQQREKAIRAAIEAGKHIYTEKPLAEDTAAALDLARAARAAGVRTGVVQDKLFLPGLRKLKRLLDGGFFGQVLSVRGEFGYWVFEGDWQPAQRPSWNYRAEDGGGIVVDMFPHWHYVLAELFGEVRAVSATIATHVPRRVDEAGRPYQATADDAAYAVFELDGGVIAQLNSSWAVRVFRDELVEFQVDGTEGSAVAGLRRCRVQHRALTPKPVWNPDLPATEDFRSQWSEVPDNEDFDNGFKVQWEAFLRHVVAGEPFRWDFLAGARGVQLAESGLLSAREGRRVEVPELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHP8</accession>
    <name>F4FHP8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S16 lon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735068.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26721"/>
    <dbReference type="EnsemblBacteria" id="AEB46417">
        <property type="protein sequence ID" value="AEB46417"/>
        <property type="gene ID" value="VAB18032_26721"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26721"/>
    <dbReference type="eggNOG" id="COG2802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048359_1_1_11"/>
    <dbReference type="OMA" id="MLDHTRK"/>
    <dbReference type="OrthoDB" id="1474822at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="233" mass="25344" checksum="54308E5A5A318AC8" modified="2011-06-28" version="1">MTARLPVFPLATVLFPGLVLPLHIFEERYRALVRHLMQLPEGAPREFGVVAIRSGWEVAPAPGRVVAGNGEVTLHEVGCTAELRQVTELADGGFDIVTVGRRRFRVEQLDRQAAPYLTAEVSWLPEPTGPDESANLLAARVIAVFRQYLGLMRPEAGQLTEQLPEDPTVLSHLVAATAALSVADRQRLLAIDDTAARLRAELTLLNREAALLRQVRAVPVPLAELATPPPGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI29</accession>
    <name>F4FI29_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_30149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AB-18-032</strain>
            <plasmid evidence="8 9">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30149"/>
    <dbReference type="EnsemblBacteria" id="AEB47993">
        <property type="protein sequence ID" value="AEB47993"/>
        <property type="gene ID" value="VAB18032_30149"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30149"/>
    <dbReference type="eggNOG" id="ENOG502ZRCY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1124163_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043760">
        <property type="entry name" value="DUF5706"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18967">
        <property type="entry name" value="DUF5706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="25094" checksum="02E70B6AE02BBC4E" modified="2011-06-28" version="1">MVPDPGDPAYLGAAYATSYDPRGPQGPRRHFTIPTAGAYAVLVEISPSLADSTFRCTGCGATDRDFSELEILARAGAHASACGRGAVTAELDVEIATVRAELGRIDPKASGYLQMAGVLLGAGLAVLGGAGASGHLPRAALAAGAVTAVVVLTAVVLLLLASRPRLGGDFGFIAYADADDAQGVLARVAAGDADQGPQLTPLAKARELWWLSRSVRAKYIAISRAVPLLLTGYAGAALTAALAIGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F132</accession>
    <name>F4F132_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07840"/>
    <dbReference type="EnsemblBacteria" id="AEB42686">
        <property type="protein sequence ID" value="AEB42686"/>
        <property type="gene ID" value="VAB18032_07840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07840"/>
    <dbReference type="eggNOG" id="ENOG503427I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1488416_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="20587" checksum="BFFFBB48EEAFC6D7" modified="2011-06-28" version="1">MVSPVPEGRLVLVCGQEGAGKSTIIRALLPCTPYSARIDAEDIGQTNPCPMDDEFFDLLRGNVAGLVERFCSAGYVNVIAGSFLRDYRDYLAFRQLLPKPTAVFLVELLVDSDVRDDRRLSRAKQTTQRWRDRVDLIPEDRTIREAANTDYRYIGVDTTNLSIVETVRWITESIPEIYRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1B6</accession>
    <name>F4F1B6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43952">
        <property type="protein sequence ID" value="AEB43952"/>
        <property type="gene ID" value="VAB18032_14200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14200"/>
    <dbReference type="eggNOG" id="ENOG502ZZTU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3259458_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="42" mass="4296" checksum="537DA895639027B0" modified="2011-06-28" version="1">MPGETTSAVTEHREQAVEGERGALLAVLVMVVLGVAGIFAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1E6</accession>
    <name>F4F1E6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytidyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14350"/>
    <dbReference type="EnsemblBacteria" id="AEB43982">
        <property type="protein sequence ID" value="AEB43982"/>
        <property type="gene ID" value="VAB18032_14350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14350"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021150_1_0_11"/>
    <dbReference type="OMA" id="CEFANAA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="333"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="471" mass="47419" checksum="B5EE2AB981B2CDC9" modified="2011-06-28" version="1">MVVLGDTLLDRDVEGVVNRLCPDSPVPVLDEMAHVDRPGGAGLAAVFAAAQGAEVVLVTALADDAGAARLGVLLAAAGVQVYPLRLAGATPEKIRLRAGGRVLLRHDRGGGVSEPGEPAEAVLRVIDRASVVLVSDYGRGVARQPALRAALAATRAPVVWDPHPRGPAAVPGVRLATPNEAEVRELVEASPGATRLATAAEGAERLRQRWRAGAVAVTLGADGALLSQAGSTPLMVPAPVSAEGDTCGAGDRFAATASLALAGGALVSEAVTEAVTEASAYVADGGVATALPQPVRRAPQPVHTAVAGDRVGVAAAAAVVARVRAAGGTVVATGGCFDLLHAGHLATLQAARQLGDCLVVCLNSDTSVSGLKGPDRPVIGQADRGRLLAALSCVDAVVIFEESTPAAALSWLRPDIWVKGGDYATGGADGEALPEAEILRRWGGHSVVVPYLDGRSTTGLIAATRATGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1I6</accession>
    <name>F4F1I6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome bd ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_20575</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733869.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20575"/>
    <dbReference type="EnsemblBacteria" id="AEB45215">
        <property type="protein sequence ID" value="AEB45215"/>
        <property type="gene ID" value="VAB18032_20575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20575"/>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_3_11"/>
    <dbReference type="OMA" id="FLINIAM"/>
    <dbReference type="OrthoDB" id="271551at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB45215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="471" mass="51872" checksum="2D084EA09A11AE58" modified="2011-06-28" version="1">MDALDVARWQFGVTTVYHFLFVPLTIGLSVLVAILQTLWHRTGNEKYLKLTKFFGKLFLINFAMGVVTGIVQEFQFGMNWSDYSRFVGDIFGAPLAIEALVAFFLESTFIGLWIFGWDRLPKRLHLASIWAAAIGTNLSAYFILAANSFMQNPVGYRFNPETGRAELTDFVAVLTNKVALITFPHTIAGSFLVAGSLLVAVALWHLIRNRDSADTPAYRFAAKFGSWVTLVSAVAVSITGDIQGKIMTQVQPMKMAAAEGLYQTESPASFSVLTVGSLDGSRELFAIKIPYLLSYLGTGDPNGTVQGINDLQALYTAQYGPGSYTPIIPVTYWSFRFMIGFGLAAAAIALLVLWTHRKGRTTPNSKWLLRAGLAMPILPLLANSFGWIFTEMGRQPWIVFGEMLTRDGVSRSVSLTEVLTSFTAFTLIYAVLAVVEVKLLLRYAKAGVPDVTPDPEPDDTDDSERPLAFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1S7</accession>
    <name>F4F1S7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27146"/>
    <dbReference type="EnsemblBacteria" id="AEB46502">
        <property type="protein sequence ID" value="AEB46502"/>
        <property type="gene ID" value="VAB18032_27146"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27146"/>
    <dbReference type="HOGENOM" id="CLU_2358884_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="96" mass="10981" checksum="E440ADBFD1E10A8B" modified="2011-06-28" version="1">MLTGHGLVDWGELIDADHPSRAFHFIYFDYVFSAESSDLRLDPHEIAEGVWVDPSEVLSYQLTPGYRRTLERYLASDAGPTDGRRGWTYRSEDRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1W9</accession>
    <name>F4F1W9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase with gaf sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736348.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03160"/>
    <dbReference type="EnsemblBacteria" id="AEB47716">
        <property type="protein sequence ID" value="AEB47716"/>
        <property type="gene ID" value="VAB18032_03160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03160"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_578636_0_0_11"/>
    <dbReference type="OMA" id="TGSWQVF"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="349"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="472" mass="50090" checksum="CF52FDCF1635B5C9" modified="2011-06-28" version="1">MDHQQVIRDVTVRLPMASTVAEVCQATVDALARYTPATIAVLLHVNGRLRCVAATGSWQVFATVAPDAGIVGRVFTGGRSAVVPDISTDPDHIPVRPDVTAEVCVPICDPAGRRIGVLDVQWTGPAELAAWRATAERVAGRLGARIMALGGPAESRSEKLLRHAAAMTAATTEWDLLATATRAARDVSALDTAMLLLSGRSGPQLSEPTATPGELETRIRAELAEAGPQALRAIVARAHRYGTGHTLGEAGHPPTEEHDPLVRAGVRTLVAVPLGSPEGGGVLLVAGERLLRPDPRTVNLLELLAGQAWTCLDRLRTLDRLREQASSDPLTGLRHTGPFGQRIATATPGRTALLAIDVDGFKTVNDTYGHQAGDRVLVGLARALEGALRQGDELYRIGGDEFVAVIEVSRPEEAVRVAERLTEAARRIGRTISVGVALPRPGESPELTLRRADQALYAVKRQGRDGVRLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F232</accession>
    <name>F4F232_MICM1</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="5" type="ordered locus">VAB18032_03475</name>
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    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
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            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
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        <property type="gene ID" value="VAB18032_03475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03475"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_223264_0_0_11"/>
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    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
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    <dbReference type="InterPro" id="IPR028908">
        <property type="entry name" value="Tox-PL_dom"/>
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    <dbReference type="InterPro" id="IPR025968">
        <property type="entry name" value="YwqJ_deaminase"/>
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        <property type="entry name" value="Gln_amidase"/>
        <property type="match status" value="3"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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            <end position="140"/>
        </location>
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        </location>
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    <feature type="domain" description="Calpain catalytic" evidence="4">
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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    <feature type="active site" evidence="1">
        <location>
            <position position="5030"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="5201" mass="533457" checksum="EE56C33B69A77669" modified="2011-06-28" version="1">[encoded data, 5201 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F267</accession>
    <name>F4F267_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">VAB18032_08190</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
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            </authorList>
            <dbReference type="PubMed" id="21551311"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF00588"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AEB42756.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="207" mass="23302" checksum="4EB2AA4A09571945" modified="2011-06-28" version="1">MTDEQYEVGVGPWPGDPPDDPRYDPQLLAEGDRRNVVDRYRYWRREAVVADLDLRRHDFHVAIENWQHDMNIGTVVRNANAFLAAEVHIVGRRRWNRRGAMVTDRYQHVRHHESIDDFVAWAGQHDLPLVGIDNLPGSRPLESSTLPRRCVLLFGQEGPGLSDAARAACDQLFSIAQYGSTRSINAGVASGIAMHAWIRAHAGPPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
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                <person name="Uguru G.C."/>
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                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
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            </authorList>
            <dbReference type="PubMed" id="21551311"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14600"/>
    <dbReference type="EnsemblBacteria" id="AEB44032">
        <property type="protein sequence ID" value="AEB44032"/>
        <property type="gene ID" value="VAB18032_14600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14600"/>
    <dbReference type="eggNOG" id="ENOG502ZBK4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055415_0_0_11"/>
    <dbReference type="OMA" id="RVGIRMY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309023" evidence="2">
        <location>
            <begin position="32"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="37692" checksum="00A465E31105D6E4" modified="2011-06-28" version="1">MRSGTTRSWSLPVAALAILVASVVIGAPADATDRDRGTGASPAPASGSIGIRLVEASVDRRDDPRARVYIVDHVKPGSRMTRRIEISNSSASTHQITIGVAAAEIKDHEFVPASEPDANELSEWTTIDPPVIVARPYSTTTVRATIAVPPSASRGERYGTIWATVGAAERRDAAMLVRKVNQVGIRVYLDVGPGGEPPSDFRIEELTPGRTEQGAPVVRARVRNTGERALDLTGKLWLSDGPGGLSAGPFPATLGTTVLPGDTTHLEVVLDQQVPNGPWQARLRVESGRLHREVTAKITFPDQKGSWGLPTTFSEQLPMIILASGVVATIAGVVMVVGYRYARRRRYQFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2I9</accession>
    <name>F4F2I9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase cyclophilin type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732728.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14745"/>
    <dbReference type="EnsemblBacteria" id="AEB44061">
        <property type="protein sequence ID" value="AEB44061"/>
        <property type="gene ID" value="VAB18032_14745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14745"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_8_3_11"/>
    <dbReference type="OMA" id="GFANEFP"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="112"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="275" mass="29109" checksum="1A5AC169CCD86843" modified="2011-06-28" version="1">MTSTRERQRAAARARLEKEMAERAARARKRRQTQAVVGGGVVLLLVVAGTVWLASSLIGDDSGTDTTAQSADTVQCDWVELPNGERSPTTKDVGLPPVEQSKVGIQTMTITTNLGPITARIDRSAVPCTAGSFIHLAEQNFFDNTKCHRLVTEGIKVLQCGDPSATGKGWRDSDGTGGPSYRMAEENLPTDKRPPYPAGVIAMANSGQPASSGSQFFIVYGDSPLDPNYTVLGTITDGMDIVEDVAKAGDDGAFAQQAGGGHPKKEVVITDLTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2K5</accession>
    <name>F4F2K5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20850"/>
    <dbReference type="EnsemblBacteria" id="AEB45270">
        <property type="protein sequence ID" value="AEB45270"/>
        <property type="gene ID" value="VAB18032_20850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20850"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OMA" id="EMVVTGC"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="150"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="30295" checksum="3225630120745A15" modified="2011-06-28" version="1">MDSAVVVGVDGSEAALAAVRLAAAEAARRHRPLRVVHAFIWPSLHSPFTPGTEGPADGGLRGQAHQLVTAAVDEAQTTAPGLRVTGEIVDGAPTAVLLQASDDAALVVLGDRGLGGFTALVVGSVAVTVAAHARCPVLVARGTADPQGPIVVGVDGSDVSRRAVEFAVQTAAFRGATVVATHAYRHPASTGPGDMQPLVYDESQLQAEEERALAESITGLTDRYPEVTIRRESVRGRAPKVLTEASRTAQLLVVGGQGRGELTGLLLGSVSRSMLHHSHCPVAVVRGDGVGPPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2L9</accession>
    <name>F4F2L9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20920"/>
    <dbReference type="EnsemblBacteria" id="AEB45284">
        <property type="protein sequence ID" value="AEB45284"/>
        <property type="gene ID" value="VAB18032_20920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20920"/>
    <dbReference type="eggNOG" id="ENOG5031SR6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146004_0_0_11"/>
    <dbReference type="OMA" id="LLWMYEN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="107" mass="12255" checksum="A90F95716E4BC9F3" modified="2011-06-28" version="1">MTTGVAHLARPGRPAVVARTLSELRGPTRGVVELPVRLMWCSDRAFDLADPDQLLWMYENVLRETTSVDDLRRLVNGRTLPRVWRLLNLPRGVRTAWESRHRGLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Q5</accession>
    <name>F4F2Q5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733974.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21100"/>
    <dbReference type="EnsemblBacteria" id="AEB45320">
        <property type="protein sequence ID" value="AEB45320"/>
        <property type="gene ID" value="VAB18032_21100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21100"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_7_0_11"/>
    <dbReference type="OMA" id="ATVWFHR"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="221" mass="24863" checksum="D89C0DD7E85107FE" modified="2011-06-28" version="1">MHQSPPVKRARWRDIDWIVDLVTATVAPTTLGAWLVPDERRRPAVLAAAARIWVEHALLFGDAFLLTDGAAATVWFHRYRPIPPPSRYGERIKDACGEHVDRFRRLDRALGACHPQEPHNHLAILAAPPDTQRASQAAAVLAGSHRLMDTFGLPIYADLYSDADRWLYQRLGYRKHHEVVRPDGARVDLLWRPASPTRIHPTPFAGPCPDQQLPEHAMTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2V1</accession>
    <name>F4F2V1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27446"/>
    <dbReference type="EnsemblBacteria" id="AEB46562">
        <property type="protein sequence ID" value="AEB46562"/>
        <property type="gene ID" value="VAB18032_27446"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27446"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507895_0_0_11"/>
    <dbReference type="OMA" id="YMGTLEA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="573" mass="60522" checksum="D551CFB6B8EF6DC4" modified="2011-06-28" version="1">MTEVRREPRPALRALPATLRTLPDSLRLPRSPRLPVLLTVLAFLAGVGYRLGLMLFDAPPTNSDEATMGLAALHISRGQEFPVWFYGQTYMGTLEAWLAAPLFAVAGPSTFVLRLPTLAMYALFVLLIWRLTLRLTGDHWFALLVVGLLALGSDRIVKNQLIAGGGYPEMNVAGAALALLAYDLAVGRPGRRLPRWTAWGFLAGLMLWVDPLVLPYVAGTGLVLVAFRWRELRGRAGGLLTLGALVGAAPLLVDSLVAVRNPLTAVLTASGAEQPAGWLDRLYGGLVLGPALGMGFCDPGRCAGWQLWWAVALPVLLAAAALTAWHTLRHPPTSPTPAGTATAATGAADPGGEAGGGAAARVGAAVTSALVGAAVATIAAYTVSSAAGRTPVESSRYLSCLLISVPVLLWPGWRATRRRRLPAGDAADHRLGGRSSATTRVAAVLVLTATLSTAIVATAGAVGRVPAVHSDEGRHVALVAALREQGVRHVYGTYWTCNRLTFASGEDVICAVVDDELRPGHDRYRPYRTAVHAAAGAAWIAPDGSPLAARLDQRLDSLDRFTVDGWHVYLPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2X0</accession>
    <name>F4F2X0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent F420 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735231.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27541"/>
    <dbReference type="EnsemblBacteria" id="AEB46581">
        <property type="protein sequence ID" value="AEB46581"/>
        <property type="gene ID" value="VAB18032_27541"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27541"/>
    <dbReference type="eggNOG" id="COG2085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_1_0_11"/>
    <dbReference type="OMA" id="IDTDVMV"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="232" mass="24046" checksum="121620F88A9B8297" modified="2011-06-28" version="1">MAYDPSDLPDVSGLTVGIIGGTGDQGRGLAYRFARAGQTVLIGSRSAQRAAQSAEEIAALPGVPADGSVTGADNDEVARRSDVVIIAVPWDGHAATVAALAEPLAGKIVVDCVNPLGFDKQGPYALPVPEGSAVQQAAALLPESRVGAAFNHVSAPLLADPEIDRIDLDVLICSEDRDLVGVVAALAARIPGMRGVYAGRLRNAHQIEAFTANLIAINRRYKTHAGVRVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Z3</accession>
    <name>F4F2Z3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pfkb domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_27656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735254.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27656"/>
    <dbReference type="EnsemblBacteria" id="AEB46604">
        <property type="protein sequence ID" value="AEB46604"/>
        <property type="gene ID" value="VAB18032_27656"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27656"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_12_0_11"/>
    <dbReference type="OMA" id="RHVHLSI"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="177"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="29636" checksum="372C803C08110DEB" modified="2011-06-28" version="1">MYDLLVLGGLGVDIRVRVPDLPLAVVDSVTVEPIDLRIGNTGAGVVLAAHALGLRVAVVDTLGTDPAGDVVRAALSRTGVHAVLASTPAGTRRSVNLVDPAGRRMSLYDPRPSDGTAPFPVAQVATLVEQATHVHLSIMNWVRDLLPALGDMLGEGVGSSTDLHDWDGQNPYHRPFAEIAELVLVSGVTLGDRSTAVGAALAPRPVLVTWGADGADLHLGGTVTRIPAATPPGPVVDTNGAGDAFAAGIITARSRGATWAEAAGYAARVAAAACTHDGMEYPPGLLPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F306</accession>
    <name>F4F306_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transketolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_27721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735267.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27721"/>
    <dbReference type="EnsemblBacteria" id="AEB46617">
        <property type="protein sequence ID" value="AEB46617"/>
        <property type="gene ID" value="VAB18032_27721"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27721"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_2_1_11"/>
    <dbReference type="OMA" id="YRNPMVV"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="5">
        <location>
            <begin position="534"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="874" mass="90596" checksum="206851487530E5A7" modified="2011-06-28" version="1">MLSDVTTPQDLDDRLRESLAALTMPRHRTDPAQPVAEGAALTGAQLLELFDAQVTSRQLDLAGRWLRSFGEGYHTISSAGHEGNAAVAAALRPTDPALLHYRSGAFYCVRAAQAAEPATGSVLLTPDNGPDGAPAPPADPAEPDDAPDPASSADPVDPAADNASTGRETDDDQAVPSAEAAPADPVVANEPGDGVPVETDATDSTAPAGDEVAGGARPAMVRRPVVSAYTEAARDVLRGMVASREEPTAGGRHKAFGRADLTVVPTTSTAASHLPRAVGMGLAVERLRRLDARGVAAHVDVAPWAPDAIVVCSFGDAAINHADATAAFNTAGWYDHTGLRIPVLFVCEDNGLGGSLRSPQGWVATALRAKPGIRYFAADGADLVATYEVAREAAAWVRRHRRPAVLHLSTVRLLGHVGADAESAYRSAEEIAADLAGDPLVATARRLVEAGLAGGAELLDRYDEIGWQIRRLAEQVLDEPKLSNPAEVIAPLAPRRPVRVAQAVADAGARAAGPDAGARLEAFGGKPPELSGPLTLAQSINAALTDALLTYPQMAVFGQDVAAKGGRYGVTSDLRDRFGPARVFDTLLDETSVLGLGLGAGLAGMLPVPEIQSLAYLHTAEAQVRGEAATMGFLSQGALRNPMVLRVAGLAYQEGFGEHVRDDNSVAVLRDVPGLVIAVPARPDDAAAMLRTCLASAAVDGSVCVFLEPVGLYHARDLYADGDGEWSAGYAEPGAWASGHVPVGRARVYGVGSAEDITIVTFGNGVRMALRAASALADEGIGSRVMDLRWLAPLPVADLIREAAATGRVLVVDETRRSGGVGEGVIAALVDAGYVGAARRVAAVDCFVPLGPAARQVLISEEAITQGARTLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F339</accession>
    <name>F4F339_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736450.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03680"/>
    <dbReference type="EnsemblBacteria" id="AEB47818">
        <property type="protein sequence ID" value="AEB47818"/>
        <property type="gene ID" value="VAB18032_03680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03680"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083240_1_0_11"/>
    <dbReference type="OMA" id="ACIRRID"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="21606" checksum="5F6DC6E2D41D5A8A" modified="2011-06-28" version="1">MPRIQAASVAEHHARQRRALLDAARALLAETEQAPSMAAIGRRAGLARSSVYQYFASAEDLLAAVVADVFPTWAGQVLERVAAAPTPGTRIWAYVVANVDLFASSEQAVARALTRVVEPRVLQGPMEEFHAQLQGPLRQALTEFGEPEPETMAELIDSLIVRASQDVGATARTQARKTADVTLARLRRLLGPYLGLGPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F355</accession>
    <name>F4F355_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736466.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03760"/>
    <dbReference type="EnsemblBacteria" id="AEB47834">
        <property type="protein sequence ID" value="AEB47834"/>
        <property type="gene ID" value="VAB18032_03760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03760"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083623_1_0_11"/>
    <dbReference type="OMA" id="DFDGPIC"/>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="24201" checksum="5E5FECF03427A99C" modified="2011-06-28" version="1">MNADLGRLLGDVDALLLDFDGPVCSIFAGYPAPQIAAELVDVLRQHGVNVPPELASEPDPLEVLRRTGTASDQDVTRAIEDALCAAERRAVETAEPTPYGREVIVAARQAGMPVAVVSNNSAGAVNAYLVAHRLAAHVSLVVGRAYAEPDRMKPNPEPILKAVRAVGERPNRCVLVGDSISDIDGARAAGVQVIGYVNRPIKLKAFQVAGADVVIASMGEIAGLLIGRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3B6</accession>
    <name>F4F3B6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08610"/>
    <dbReference type="EnsemblBacteria" id="AEB42840">
        <property type="protein sequence ID" value="AEB42840"/>
        <property type="gene ID" value="VAB18032_08610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08610"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_11"/>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="213"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="484" mass="51832" checksum="A508AC23D48583E7" modified="2011-06-28" version="1">MNVLYGLYQPDEGEILVDGEPLKLRGPSDAIAAGIGMVHQHFMLVPVFTVTENIMLGAEQVRGGIAGFLDRRRARREVAEVSQRYNLRVDPDAMIEDLPVGVQQRVEIVKALTRDVDLLILDEPTAVLTPQETEDLLAVMRSLKAAGKSIVFITHKLGEVKAIADRITVIRRGRTVGTASPQASRDELAALMVGRTVRLTVDKTPATPGEPVLEVAGLVVDDDRQVRAVDGVDLTVRAGEVLGIAGVQGNGQTELIEAIMGLRPLLAGTVTLDGQRIDGWSTKKVLRAGVGYVPEDRSVDGLVKEFSVAENLVLDIYDRPPFGRGLSIKPDAIARSARERIEQFDVRTSSAQAPVGTLSGGNQQKVIVARELSRPLKLFIAAQPTRGVDVGSIEFIHSRIIRERDVGTAVLVVSSELDEVIGLADRIAVMYRGQIIGIVGPDTPREEIGLLMAGITPDSTGDAPATTDGVASGPEGPGSKDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3I2</accession>
    <name>F4F3I2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14890"/>
    <dbReference type="EnsemblBacteria" id="AEB44090">
        <property type="protein sequence ID" value="AEB44090"/>
        <property type="gene ID" value="VAB18032_14890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14890"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495796_0_0_11"/>
    <dbReference type="OMA" id="DVNPGWV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="544" mass="57401" checksum="B0C6838210DE1CCA" modified="2011-06-28" version="1">MLLFDNVATVAFMTDAQPGWSGGTVAARTVTLTDLLRVPLHRIRLVAAVAVLGLAAAIGYVFLIPGAVSASAVVAVRPVVTDAFTPSGAAADRAVNMNVESGIATGTDVVQRLADAGGRDPRDVRDALDVEVPAGGQILRFTFTADSAESAVNNANLAAQSYLDVRRNMYERQREEMLRSYDKSIEDVAARQAALQKRMANARDGAREAVVAELAGVNNQLTQLSSARTEIAAVDVNPGWVTQSAEKALVSSSGRGPLYVAAGLLGGLLFGVVLAYAWESMDRRIRSVDDGRDATGLPLLGTVRGQGLFGRRRPVDADIRYVAMAIAERVREPARIALLTTREDQTPLTAGLAVALAATGRDVYVADDSGRLDELRATVMTDRGRLPAAVNPARPTIPKPRPDGSGSIDDVTELITPVRRPSPHPNPARPAAGDPEATMMLPRMSGGPVTAKSPVTEQADEVPVGAGGVRFGTWRQRAAQGLVLFNAPPAEADERGVAAARQGTAVVVVEQDRTKQGDLRRLAERLRAAGVAPLGFVLTRTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3J6</accession>
    <name>F4F3J6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ordered locus">VAB18032_14960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732771.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14960"/>
    <dbReference type="EnsemblBacteria" id="AEB44104">
        <property type="protein sequence ID" value="AEB44104"/>
        <property type="gene ID" value="VAB18032_14960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14960"/>
    <dbReference type="eggNOG" id="COG0757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090968_2_1_11"/>
    <dbReference type="OMA" id="AYTHYSY"/>
    <dbReference type="OrthoDB" id="1872106at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB44104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="146" mass="15853" checksum="442C23A06B33F91F" modified="2011-06-28" version="1">MKVYVLNGPNLGRLGTRQVDVYGTTSYADLVTLCETTGRDLGLDVVVRQTDAEHELLGWLHAAADEGAAVVLNPAAWSHYSIAVRDACAMLRGPLVEVHLSNIHAREEFRHRSVVSAVATGVICGLGVDGYRLALHHLAARRDQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3K2</accession>
    <name>F4F3K2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pyrC</name>
        <name evidence="7" type="ordered locus">VAB18032_14990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732777.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14990"/>
    <dbReference type="EnsemblBacteria" id="AEB44110">
        <property type="protein sequence ID" value="AEB44110"/>
        <property type="gene ID" value="VAB18032_14990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14990"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_11"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="48"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="339"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="443" mass="46632" checksum="172E0C97FCAFE815" modified="2011-06-28" version="1">MNSYLIRNVSVLGAAPTDLLLRDGVVAEVGRGLSAPDAVVIDADGLVALPGLVDLHTHLREPGREDAETVETGSRAAALGGYTAVCAMANTSPVADTAGVVEQVWRLGREAGLVDVQPIGAVTVGLAGERLAELGAMADSAARVRIFSDDGHCVADPRLMRRALEYVKAFDGIIAQHAEEPRLTEGAQMHEGEVSTRLGLTGWPAVAEEAIIARDVLLTEHVGGRLHVCHVSTAGSVEVLRQAKARGVRVTAEVTPHHLLLTDSVVGGSNELASPAIADTWHPAGAYDPVYKVNPPLRTAADVAALRAALVDGVIDIIATDHAPHAVEDKECEWAYARPGMLGLETALSIALDVLGPEWDMIAERMSRTPARIAGLTEHGRDPAPGVPANLTLVDPASRRLIDPAESASRSRNTPYARMTLPGRIVATFLRGEATVLDGKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3K9</accession>
    <name>F4F3K9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanylate kinase/L-type calcium channel region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15025"/>
    <dbReference type="EnsemblBacteria" id="AEB44117">
        <property type="protein sequence ID" value="AEB44117"/>
        <property type="gene ID" value="VAB18032_15025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15025"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129875_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="15645" checksum="EF4251F588ABA5AD" modified="2011-06-28" version="1">MWRPIPVTTRPRREGELDGVDRHFLTPEQFERRLAAGDLLEWSRFGAHRRGTEIAPLRSRIAAGVPVLLPLDLDGALLVRAAWPQARLVLLHPPGRMPVPTVTTAFDHAVSYDRTEQVVDELVGFIGSSFLAPARPRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3V9</accession>
    <name>F4F3V9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylose isomerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734063.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21550"/>
    <dbReference type="EnsemblBacteria" id="AEB45410">
        <property type="protein sequence ID" value="AEB45410"/>
        <property type="gene ID" value="VAB18032_21550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21550"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_0_11"/>
    <dbReference type="OMA" id="WYIIEQD"/>
    <dbReference type="OrthoDB" id="1194699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="103"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="335" mass="36026" checksum="E7C74D7C453FF333" modified="2011-06-28" version="1">MCYGYDGEAALRRSVIDRRGLLRGSLAAAAGVGLVASGIGATAATAGPGHGHGPGHGHGHGPGHGHGPGHAGRHHVPPGLISIQLWTVRDALNGSPGYDATLKHLARIGYPKVELALGYFGRSAGQLRRLLDSIGIKASSSHDGISADAAALRQKIQDAVTLGQKYMVVPYLYSESADEWKRWAEQMNVEAAAARRAGLRYGYHNHAHEFTIDLGGGRTPWDILTAELDPKLVHLEIDIYWAVTGGIESGAGAADPEGFTLDVIRRAPQQVLQYHVKDRHAADGDMADLGTGMIDFARIFRGHAVQEYIVENDTPDVTPQQTAEVGYRYLRKLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4A6</accession>
    <name>F4F4A6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">moaA</name>
        <name evidence="14" type="ordered locus">VAB18032_04185</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47919.1"/>
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        <location>
            <begin position="13"/>
            <end position="231"/>
        </location>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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            <position position="73"/>
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        <ligand>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
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    <sequence length="336" mass="36099" checksum="B57FE357A6B0498C" modified="2011-06-28" version="1">MSVAPPGGLLVDRYGRTARDLRVSLTDKCNLRCTYCMPAEGLPWLAGPQLLTDDEVIRLVRLAVHRFGVDEVRFTGGEPLIRPGLTAIVAAVAALDPRPRISLTTNGIGLARLAPALHAAGLDRVNVSLDTLDRDRFLRLTRRDRLDDVLAGLAGAAAAGLTPVKVNSVLMRGVNDDEAPALLRFALDHGYELRFIEQMPLDAQHGWDRSSMVTAEEILATLGAAYELSPDPAGRGAAPAETWLVDGGPARVGVIGTVTRPFCGDCDRTRITADGQVRNCLFATEETDLRGALRAGADDDELARRWSAATWRKRAGHGIDDPSFLQPARPMSAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4H9</accession>
    <name>F4F4H9_MICM1</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">VAB18032_09095</name>
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        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="eggNOG" id="COG1322">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
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        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="390" mass="42735" checksum="9A0840CF36321FFD" modified="2011-06-28" version="1">MELATLAVVVVCLGAGGAVGWFAARTRAATEIARLDATLRATREGEGRLEQSMRALSYEATAQSQEAVARAVAPLHDTLRRYEQRVAELERDRIDAYAELREQVRAMSSVSGELRTETKQLVAALRAPQVRGRWGEHQLRRIVEAAGMLEHCDFSEQVTAATDQQTVRPDLVVRLHGGRTVVVDAKAPFDAYLTAMEARDERSRDTQLDNHAKHLRAHVDALAAKSYWTAFESTPEFVVLFVPADPFLDVALQRDPTLLEHAFARNVVLATPATLIAMLRTVAWSWRQEQLARNAVAVHSLARELYGRLSTLGDHVGKLGASLGGAVTAYNRAVGSLEARVLVSARKLAELGVSDQELATPAQVELAPRQPQAPELLVEESISDGRSRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F534</accession>
    <name>F4F534_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_28226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735366.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28226"/>
    <dbReference type="EnsemblBacteria" id="AEB46716">
        <property type="protein sequence ID" value="AEB46716"/>
        <property type="gene ID" value="VAB18032_28226"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28226"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OMA" id="GHDHVHP"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="254" mass="26220" checksum="E5AAB539416AF4E5" modified="2011-06-28" version="1">MTPEVITVTHGVVGYDGRPVLRDVSLTVTAGEVVAVLGANGSGKSTLIRAVLGLVPLSSGSVTLFGEPARRFRQWHRIGYVPQRLGAGSGVPATVAEVVASGRLARRGILRPPGRADRTAVTEALHAVGLADRAKDPVATLSGGQQQRTLIARALAGKPELLVLDEPTAGVDAASQEAFAEALRGFTDGGGTVLLVAHELGPLQPLISRAVVVHQGLIAHDGAVPEPAGHHAAPDHDHVHPHCPEEPAGLWGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F541</accession>
    <name>F4F541_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735373.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28261"/>
    <dbReference type="EnsemblBacteria" id="AEB46723">
        <property type="protein sequence ID" value="AEB46723"/>
        <property type="gene ID" value="VAB18032_28261"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28261"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_3_11"/>
    <dbReference type="OMA" id="NYYANKF"/>
    <dbReference type="OrthoDB" id="1439833at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="29769" checksum="E07083D767AFAE7E" modified="2011-06-28" version="1">MHIDARGMRFDVTAGGPEHGEPVLLLHGFPQHAGEWNDVTPTLHVAGLRTYAVNQRGYSPGARPTEVEAYRLTELVADAAAVLDALGVDSAHVVGHDWGAVVAWALAAEHPERVRTLTAVSVPHPAAMAYALSEDSQQKARSAYMLLFRRPGVAEKTLLALGARGLRRMLRGVGDAARVSAYAEPMREPGALTAALNWYRAMSWTDLAATGPSRVPTTFVWSDRDVAIGRTAAEACVKHVQGDYRFVEIAGVSHWIPDEVPTRLAEAIVARVRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F577</accession>
    <name>F4F577_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-hairpin-helix repeat-containing competence protein ComEA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28441"/>
    <dbReference type="EnsemblBacteria" id="AEB46759">
        <property type="protein sequence ID" value="AEB46759"/>
        <property type="gene ID" value="VAB18032_28441"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28441"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052011_0_1_11"/>
    <dbReference type="OMA" id="VDWRKEH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="24915" checksum="37DAAB61FC107C87" modified="2011-06-28" version="1">MEPSVGPGSADPGPSVGPESSDSQSGPDAAEVVSASRLPGPGAFDPGRRGVRALAVVAVLVVLGAAGWTWRSRPQVEPVSAVTGAPTTVPSGNRGNEPGDEGADGATGEVVVAVAGKVRRPGLVRLPAGARVADAVEAAGGALPGVDVAMLNPARKVADGELILVGVAAATPAVGAAPGAGPAAGADPGGRLNLNTASQSQLETLPGVGPVLARRIIEHRDEHGGFRSVSDLRQVNGIGDARYEELKDLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5F3</accession>
    <name>F4F5F3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aqualysin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_09335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731656.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09335"/>
    <dbReference type="EnsemblBacteria" id="AEB42985">
        <property type="protein sequence ID" value="AEB42985"/>
        <property type="gene ID" value="VAB18032_09335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09335"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383522_0_0_11"/>
    <dbReference type="OMA" id="WIVANAA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307428" evidence="7">
        <location>
            <begin position="34"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="147"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="721" mass="75461" checksum="FE9FD27AFEA7BA81" modified="2011-06-28" version="1">MARVPRRRFLAAAAVCLLAATGGLLAPPAPAFAAEKFAPAPGAAVADSWIVVLRGDATRDVDGSARSLLRRHPGALAASYRSALPGFAVRMSTADARRLSQEPQVAYVAQNSLLLPQATQTNPPWHLDALDQHGGAFDGSYAYDTTGQGVHVYVMDSGMRHTHTDFGGRATGDVNFVPQGIDQWGTGDCSGHGTQVAGLIGGTVHGVAKGVRLHTVRVGGCTPGQVVWAISALDWIVANAARPAVVNMSLATTANQALDDAVNAVLTAGIPVVASAGNHGQNACGYSPARVPDVITVGMVHALRDRLPNSNFGPCVDLFSFGEQVPTVTATSDTSTTTGFGGTSAAAPIVTGAVARYLQRFPTASPRTVATRLADEATRDRITNPAGSPNLVLHVDPGGPGNDGFSGRYADVNGDGRDDIVSFTRGAQPEVYVALSNGASFGAVTRWHTYFAAGQEFPMLADVNGDGRDDLITFTRGTTADVYVALSTGTSFAPSQLWHTWFAAFKETPVVGDFNGDGRADIATFVRENVRDVYVALSNGTQFVGTSVRWHDNFVGDDDVPLVGDVNGDGRDDIIAVDRFTGTAASVGLSTGSGFVLAYQWLDYFLNLGSSEVPLVGDFDGDGRDDLAAVNLNGQYADVALSAGNHFLPRTRWAWTIPGGGAIPGAGDFTGDGRADLVAFSRGTVAHVHVVRSTGSHFTDLRRWHDNFAGGTAIPMPASLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5S0</accession>
    <name>F4F5S0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage/plasmid-related protein tigr03299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732947.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15865"/>
    <dbReference type="EnsemblBacteria" id="AEB44283">
        <property type="protein sequence ID" value="AEB44283"/>
        <property type="gene ID" value="VAB18032_15865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15865"/>
    <dbReference type="eggNOG" id="ENOG502Z7QU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058825_0_0_11"/>
    <dbReference type="OMA" id="GGRKFWA"/>
    <dbReference type="OrthoDB" id="1540547at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026325">
        <property type="entry name" value="DUF932"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017686">
        <property type="entry name" value="Phg/plasmid-like_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06067">
        <property type="entry name" value="DUF932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03299">
        <property type="entry name" value="LGT_TIGR03299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="36428" checksum="C5EFB17BADF1E4A1" modified="2011-06-28" version="1">MPHELETFADGTTAFASARLSAWHQLGTVTQDTMRAEEIMAAAQLGDWGVRTIRTVGIDIVDGVEVQIPADDKRMTVRRNPVTGQTEYLGIVGTDYTVVQNEQCAEMLDRLVDQVGGAHFETAGSLRRGKSVFVTMKLPDAMEIAGVDRLDLYLIGTTSHDGTAALRVDASPIRVVCANTQRAAFANAVGHYTFRHTSNVNSQISQAREALGLMWKYIETFEKAAERMLQTEMTMREFEQVVGQVWPVKDNASEQTKNNAKQRLGTLKYLIREADTQKAITGSRWAGYQAITEYLDHYQPAKNDIARANRVLTGNAGDLKLAAFDLLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5X7</accession>
    <name>F4F5X7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734189.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22180"/>
    <dbReference type="EnsemblBacteria" id="AEB45536">
        <property type="protein sequence ID" value="AEB45536"/>
        <property type="gene ID" value="VAB18032_22180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22180"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367975_0_0_11"/>
    <dbReference type="OMA" id="LIDEVHW"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="447"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="756" mass="80118" checksum="64216BD8BEB8C9B0" modified="2011-06-28" version="1">MRFDSMVDAIGHTPLVRLRTSGDVQLFAKLELQNPYGMKDRVAREVVLAARESGELAPGAPIVESSSGTLALGLALVGTVLGHPVHIVTDPRIDPITLAKLRSLGCVVHVVPAMARHGWQSARLERLADLRRELPGAYWPQQYGNPLNPRAYQALAREIVADLGPVDVLVGSVGSGGSLCGAARALRAYRPQLRVVAVDCVGSVLFGQPDLPRRRQSGLGNSLHPENLDHTVIDEVHWLNDREAFAATRDLAREQGIFAGNSAGSVYQVMKGLTGLLAPGTRVVGILPDRGDRYAENLYDDGYWVEQKLDDLPLAREPVQVPYGSRVTSWSYAPVPPRELVFVESNTTGTGMLALHQAVRLGLRPVLLTHRPGRYRGLPETPAEVVECDTNDVDALRALLSRRRSLAGVTTTSEFYLETAATLAGGLGLPGSSADAVAVCRDKARTRDLLSRAGLPQPRYSVVRAPHEVAAAVARAGLPCVVKPTSDSASTGVRLCRTEAEAQAQVATLLAVTVNVRGQATYAAVLVEQYLAGAEVSVETFAADGRVEIVGITDKTIGPEPYFVETGHIFPAPHRPESEAIRQTARSALAAVGLAHGAAHVEMRLTEAGPVVVEINARLAGGMIPELIRLATGLNLVERQLRAASGLPLEPLAPATRYAGIRFLTTATTGVLHAVDGAEEAAALPGVHDVTVTARVGAAVGPATDAYGRLGWVIADGDSPEQVRARLDQALGRMALDVTPASDGTAAADEKVTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F655</accession>
    <name>F4F655_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase VAB18032_28681</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_28681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28681"/>
    <dbReference type="EnsemblBacteria" id="AEB46807">
        <property type="protein sequence ID" value="AEB46807"/>
        <property type="gene ID" value="VAB18032_28681"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28681"/>
    <dbReference type="eggNOG" id="COG4552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050659_0_0_11"/>
    <dbReference type="OMA" id="WNEGRWR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="410" mass="45126" checksum="21841242DFC4D88A" modified="2011-06-28" version="1">MTSTSLPISSARAEDFDEMGRFLNFLFHHGLEPEAHETERVIFEPQRALLVRDGPEVVGTTAAFTRALGVPGGEVAAAHVSMVGVAPTHRRRGLLTALMRRQLREVHAARREPVTVLWASEGRIYPRFGYGLAAQRLQLTGDTNELRLPPPTADEGRLRLDRPADRLADLSRVYDTVRAGRPGWSARDDRWWRYVLLDPEAHRGGATERRVVLHEGADGVDGYGLFRTKSDWDGTGPKCQTSVDEVVATSVAGYRAIWRMLLSIDLTRQVSFLRAAVDEPLLRLVDEPRRLNPRLVDALWVRVVDVPAAMAARRYATDVDVVIEVSDDLLPENTGRWRLQGGPKTASCVPANGPADLACDISCLGELFLGGSTLTALADAGRVRELRPGALAAADPAFIWHRAPSALEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6B4</accession>
    <name>F4F6B4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09710"/>
    <dbReference type="EnsemblBacteria" id="AEB43060">
        <property type="protein sequence ID" value="AEB43060"/>
        <property type="gene ID" value="VAB18032_09710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09710"/>
    <dbReference type="eggNOG" id="ENOG502ZY4N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037015_0_1_11"/>
    <dbReference type="OMA" id="THRRMRI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313617" evidence="2">
        <location>
            <begin position="33"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="450" mass="47616" checksum="528539B32FFCAFE3" modified="2011-06-28" version="1">MSAPTVHRRRHRILIPVLLSALVVITTLVTHAIDQPDQTDAGFLSPLSTGDDGGSRLAAGLAERGVQVQRETDTLAALRAARSRPATLFVPAPELLHPQTVDYLNLLPGHTRLVLVDPPRRVLAAAGMPLRPAGRRWAARAVTPHLTGPCALPEVTGATAAVARQRYAPTGPPGSVDLCYSAGLARLPGAAENVVVGASDPFRNGRIGEWDNELFATALLATTGRVLWLDLDGPAPPPPTPSTVRTTPPSEPDEEPYDEPDGDQGDLGAGDSTETMPPAPPGGNASGSDGPGREQTSNPLWSAFPPWFWALLAQLALAALLIAIARARRFGPPTPEPLPVTVPAAETVFGRARLYHRAKAHQSTAEVLRAAAKDRLGRRLQLPAGTPDVAAVVAAETGEHPDTVRDLLQGDAPDTDQELLELAKELDRAARDPRPSPVRPPLPRSEGDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6J3</accession>
    <name>F4F6J3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732981.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16075"/>
    <dbReference type="EnsemblBacteria" id="AEB44321">
        <property type="protein sequence ID" value="AEB44321"/>
        <property type="gene ID" value="VAB18032_16075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16075"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072751_0_0_11"/>
    <dbReference type="OMA" id="AHWERAN"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="32634" checksum="B846BAE7918A6B0E" modified="2011-06-28" version="1">MRILVIGGSGLIGASVVAVLREHGHDATTVARTARDGVAHRLDVESASVDDLRRLLAGHDGVVYATRTDEQRPLPKPIYPTFRRDNVDPVVRLCTAARREGLTRGAVMGSYYTYFDRLHPQWRLAERHTYIRCRLEQAREGRAAAGPDLPVAVLELPFVFGRAGDRLPNWAGPLDRWARSRTPLVAPTGGTAATSARSVAEIAVDALERASGADIPVADVNLTWTDMLTRIAEAVGRRRRVARLPAAAARAALCLGGAAQALGGKESGINPTYLADLLLADLFIEPTTGRPLDAALRETFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F728</accession>
    <name>F4F728_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735541.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29106"/>
    <dbReference type="EnsemblBacteria" id="AEB46892">
        <property type="protein sequence ID" value="AEB46892"/>
        <property type="gene ID" value="VAB18032_29106"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29106"/>
    <dbReference type="eggNOG" id="ENOG5030HTA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123518_0_0_11"/>
    <dbReference type="OMA" id="GQIRWQW"/>
    <dbReference type="OrthoDB" id="1612045at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="230" mass="25465" checksum="398874EC2F5AF8E7" modified="2011-06-28" version="1">MHDDASPFFIAPHRFDAMDDTGPTLDRRHELVPASDEWILGRWQVDVAGHLLGPTESRRTWALPHTVTVTVTDHRLVYVGTGPQLAVVGGRHRRASSGPVSGQIRWQWPSRLELSPCGLDSPARLLVVCDALRTIQQPALALIGPDAQIAQVSQEIRRAVATFRLTRPELMDLSPPERDALSRLALVSPVPGPTRVILPGSLPVEFRSRDDYYRPRTAVQLPYGEASGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7C2</accession>
    <name>F4F7C2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA ligase D, 3'-phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731851.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10310"/>
    <dbReference type="EnsemblBacteria" id="AEB43180">
        <property type="protein sequence ID" value="AEB43180"/>
        <property type="gene ID" value="VAB18032_10310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10310"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_2_0_11"/>
    <dbReference type="OMA" id="GPHWQTP"/>
    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="2">
        <location>
            <begin position="264"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="348" mass="39421" checksum="AC979053828916E4" modified="2011-06-28" version="1">MADRLEEYRRKRDATRTPEPVPAERRRRRSGGDRRRFVIQQHHARSLHWDLRLEHDGVLASWAVPRGLPREPGRNHLAVHTEDHPMEYLDFAGEIPAGEYGGGQMIIHDRGTYHCEKWQEREVVVDLRGDRTAGRYVLFATGGRDGRDWMVRRTDPAPPGWTSMPDLVAPMHTTSATRLPNDPANWGYELSWDGVRAVAYVSGGRLRLLSATGEDITGEYSWLRPMAETLAPTEAVLDGVLVRIDRAGRVRPARGGRGTTDAQYLLVDLLWLEGSTSTDLPYRQRRELLEALALTGPHWQTPPWFPGSGAEARHTAREQGLPGVIAKRLDSVYEPGRRSRAWRRIEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7M3</accession>
    <name>F4F7M3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733119.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16790"/>
    <dbReference type="EnsemblBacteria" id="AEB44462">
        <property type="protein sequence ID" value="AEB44462"/>
        <property type="gene ID" value="VAB18032_16790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16790"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_5_0_11"/>
    <dbReference type="OMA" id="QWFACHG"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="162" mass="18102" checksum="6A176C2D2389975E" modified="2011-06-28" version="1">MVRHDTFTISRHLDVPPGEVFTAFADTAIRRGWFRLPGSGASYEHDFRVGGGETASSTFTGLDTAPERLEYRSRYIDIADAHRIVYGYEAIVDGVLRWTSLVTVRLDAETDGTRLEWTEQVAFLKYTGDGSTDLAHLRGASVLRLNGLDAVLQSGRQRQQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7P2</accession>
    <name>F4F7P2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_22895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734331.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22895"/>
    <dbReference type="EnsemblBacteria" id="AEB45679">
        <property type="protein sequence ID" value="AEB45679"/>
        <property type="gene ID" value="VAB18032_22895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22895"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_1_0_11"/>
    <dbReference type="OMA" id="LIMWRLS"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312760" evidence="7">
        <location>
            <begin position="34"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="18"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="299"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="492"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="753"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="851" mass="87166" checksum="DC7A721ECC6D5206" modified="2011-06-28" version="1">MFRATLKSLLARKVRLMLSGLAVVLGVMFVSGAFVLTDTLGRTFDQIFADAYEEVDVSVAAKPKVQGNEFEGPQLAGPVPAAALQTVQSVDGVAEATGVVAADGARLIGSNGKVVASFGPPQLGGNWVGESDLVQLREGREPQTDDEIVINKGLATTADVAVGDRVGVLTLQPRKDFTIVGIFGYSGDRDSMGGANEIMFTTPAAQELMLGEPDVYTNIVATAATGVSDEQLRDAVAAAVGDAYDVKTGEQLSADAAAGLKEGLSFFNRILLGFAAVALLVGTFLILNTFSIIVAQRTRELALLRAVGASGKQIIGSVVMEAIAIGLIAAVFGLAAGIGIGALLAYLFSNLAGGMTLAGIAVPASAVIGAFGVGLVITVLAALLPALRAARIPPIAAMQDVATPDRPLTKITIAGAVVTAIGATLLFLGLGGYADSNTLATILGGVLFAFIGVALLTPLISKPVVAALGAIFSGWVPGKLGRLNSGRNPRRTAITAAALMVGIALVTGITVILDSAKSSISGLAQDTVKAELVIAGAQSGPRPPTFDPAVLDEAKTIPGVRLVDGLYGDMSLVDGKRTYTGAVTEPAALRQVYSLTASAGNIDRLGPGELLVSTDTAKDRGLSVGSTVPIQFARGEAQTFTVTGIFDDSPLFTGVQMVVPTQSAADFTIPQPIQGFVQLEPGTAVDQVQPRVEALLANSPEVSVVSLDAYIEQQAGQLDSLLTMIRILLALAIVIAVLGIINTLALSVLERTRELGLLRAIGLKRSQTMGMITVEAVVISVFGALLGVVVGTGLGAAVVEALRDEGITDLVLPWGQMGVFLGLAALIGVIAAVLPAIRAARINVLGAIAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Y3</accession>
    <name>F4F7Y3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735606.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29436"/>
    <dbReference type="EnsemblBacteria" id="AEB46958">
        <property type="protein sequence ID" value="AEB46958"/>
        <property type="gene ID" value="VAB18032_29436"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29436"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376772_0_0_11"/>
    <dbReference type="OMA" id="RQFEEYA"/>
    <dbReference type="OrthoDB" id="937807at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="756" mass="81334" checksum="E258073F4B2425A6" modified="2011-06-28" version="1">MSHGEELFALGGDVTTEPSFESALRGYDKRQVEKYVARAEHEIAALEAEREQAFAQIHKLAGQVEVLQRDLAAVRKQAAVVDRAAFRHLGPRVEQILALAEEQAEDILAVANEEIEARRAAAEHIIDEARAEAAEALKDFEIALAARRAEEERQAAARRAESEAASKAAKEEAARLRKSAQEALAKAEQEATQLRDAAKEIHQRAQQEATKLREAAREAHATAQQEATQLREAAKEVHTKAQQEAKRLVDQATEAGRATHAKASQEAKQIIDDAAEAGRAARNKARQEAERLTTQATEAAKRTRAETEAYAQRMRNETEAYVQHTRAQAQQELGAWRAGVEKEVNGRREAADRELAQRKAAAESEFTSRRDELDRQHQARTVELEQRLSARTAKLEEQIRTRTAELESGFETRRAELESEYTARKNEIEQGADQIRQAAEQDAAAVRARAEEQAGELVRQAEADTAEQRRAAEEYATDTRREAEEFATTARREADEYVASSRRQFEEYAATTQQHLATTQQHLAATQQEAAAGRQQLAQVMLEIAKAQQQLADLRQETWKSRQESDELQRKLLELRLEAATTPDGPTSPAPAGSSSPAAAPSAATVARTVDGPSVNGGSPANGTPVAVPADAPVNGHRPALETAGVAADGGDPTADGAGSMTPAADGAGPVTKPAAEPVTTVDDSPTAKPAVEPATVDGGTASAGVDGEPTVAAVPGTGGRGATPTKITSTGEGGKRPSKPTTDERSAKPSKITSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F858</accession>
    <name>F4F858_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PDGLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_10505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB43219">
        <property type="protein sequence ID" value="AEB43219"/>
        <property type="gene ID" value="VAB18032_10505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10505"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137910_0_0_11"/>
    <dbReference type="OMA" id="GDCIAQH"/>
    <dbReference type="OrthoDB" id="2022748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309155" description="PDGLE domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="8">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="134" mass="13657" checksum="9C41A3AFC6E3BDA8" modified="2011-06-28" version="1">MKRFWGFLAGGLLVALLLAGVVSNFASPHPDGLDSSLREGCTVDADGEITGGSCPAQQEKEHEIGGPLADYGIAGIDNELLSTGLSGVLGVLLTFALAGGAFWLVRRRGTDPTPQPVGPTQEPLDAGTPASSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F861</accession>
    <name>F4F861_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">VAB18032_10520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10520"/>
    <dbReference type="EnsemblBacteria" id="AEB43222">
        <property type="protein sequence ID" value="AEB43222"/>
        <property type="gene ID" value="VAB18032_10520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10520"/>
    <dbReference type="eggNOG" id="ENOG5032U2Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065134_0_0_11"/>
    <dbReference type="OMA" id="SGEPYLE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="384" mass="39223" checksum="314395F28D13EE9B" modified="2011-06-28" version="1">MDAGEHHRRGGGGRAVSRALLTRAGLLLAGLVTTLIATAAPAVAHGADAPNGTDYRVEIGAVAPDRPHLSVRVIEAGARLELTNTGDQPVEVIGYSGEPYLRVGPDGVYENLRSPATYLNRTIAGETVLPPEVDPAAAPQWRRVESGSTARWHDQRALWREAGPPAQVRAAPDREHRVRDWVVPLRDPDGPAEIRGSLHWVPPPDAYPWWVVAVVGALAAGALGLLPAASAPGRRALAGLGGLLAVGGVAAVLLAVGRTLDAGATGVGAMLLGLLTGPVWTLLSGLGALAAGGWAVRRRTGADFPLALAGACLALFAGVTNAALLARSVVPVPWPPTLARVLVVLAVGAGAGALAAAVLRLHAAGRAATRSVPVAVATVSSERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8A5</accession>
    <name>F4F8A5_MICM1</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ordered locus">VAB18032_10740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10740"/>
    <dbReference type="TCDB" id="9.B.227.2.1">
        <property type="family name" value="the uncharacterized 9 or 10 tms protein (yndj) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43266">
        <property type="protein sequence ID" value="AEB43266"/>
        <property type="gene ID" value="VAB18032_10740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10740"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064500_0_0_11"/>
    <dbReference type="OMA" id="FVPGRIW"/>
    <dbReference type="OrthoDB" id="1473120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="33688" checksum="F3E1A07E443530B5" modified="2011-06-28" version="1">MGLLLAVTAIFIVITLRGQDWSTVAATLRGQRPGFVATMVVLAVLANAAGLVATMISWRAMLAGVGERVAAVDAARIFYFGQFVKYVPGKVMGFLVSVEMGRRIGVPAARMGTAWLLALVVSLLTGATVGLAAGPEVFGASAAWLLLAVAPVAVVLVRPELVGRAATLLARVRRRPEPSTAMSGTGIRQAVVAQLLAWLIGGAHLWLLAVAMGAPPLRALPLCLGAFGLGAVAGVIAVFAPDGIGVREVVVTAALSVILPVPVASVVALVSRVVVTVSELVTAGIGLGVTEAILRRRARTSPAAAAEVVPVNVGSPASKKSPSCLPQADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8E5</accession>
    <name>F4F8E5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733145.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44490">
        <property type="protein sequence ID" value="AEB44490"/>
        <property type="gene ID" value="VAB18032_16930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16930"/>
    <dbReference type="eggNOG" id="ENOG5034BVH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1389705_0_0_11"/>
    <dbReference type="OrthoDB" id="2189549at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="196" mass="22567" checksum="98FAA196494D483F" modified="2011-06-28" version="1">MLNRFVEAPWQRHDRVVVEAAEGRWFPDEIGRNEGEIAFLEQLRREASGWDVDGLSPEDDTSSQVWLAPLYVDVDVPGLTIRRRTLQVGYWTNGPFGQALHGVWGDDYLLDDHDGNDPENLTVVGVRASHENYAQWAAAWLLRQLKRPVVREEWLTGDRVAAATWRLDDTGRVLARHGNGFRRLMRRRADRVVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8G0</accession>
    <name>F4F8G0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733160.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17005"/>
    <dbReference type="EnsemblBacteria" id="AEB44505">
        <property type="protein sequence ID" value="AEB44505"/>
        <property type="gene ID" value="VAB18032_17005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17005"/>
    <dbReference type="eggNOG" id="ENOG502Z8GQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054022_0_0_11"/>
    <dbReference type="OMA" id="IEICTDC"/>
    <dbReference type="OrthoDB" id="1120490at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="315" mass="34180" checksum="08E224DB44F01D33" modified="2011-06-28" version="1">MIEELIQQVAEDGDAIEELCQIADTDPGRLTPHLGSLLDLDVLWPAKLYRAADADVVHRIIERIDGGRTPECLNHLLVILAHTAHPLAENALRRWSAEPPGGADQLYVPVLTYAHEGGWTVTPDGHRRELCGSTAYQWVMRDTPRRADGPTCPWCSSPLWIAADLDTTEPAVAAALAHTGWSGRLVIETCHFCACYTPLYSQVTPTGSTTWWTGNTRPEYIGSAEPEDPPALAPVPGAARPSPYQACAWSRGGSTLGGWPDWIQDAEHADCPGCGQPMDYVGLVGGADLDDYGEGAYYLHLHQPCGFAAVNYQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8H4</accession>
    <name>F4F8H4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17075"/>
    <dbReference type="EnsemblBacteria" id="AEB44519">
        <property type="protein sequence ID" value="AEB44519"/>
        <property type="gene ID" value="VAB18032_17075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17075"/>
    <dbReference type="HOGENOM" id="CLU_3031191_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="6159" checksum="C165A97A58864026" modified="2011-06-28" version="1">MKADVTVWTADVMQNPKLTDSLRERPRAPSPRVGTARWAPRRRPPIAMIGGRHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F971</accession>
    <name>F4F971_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crgA</name>
        <name evidence="5" type="ordered locus">VAB18032_04865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730773.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04865"/>
    <dbReference type="EnsemblBacteria" id="AEB42099">
        <property type="protein sequence ID" value="AEB42099"/>
        <property type="gene ID" value="VAB18032_04865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04865"/>
    <dbReference type="eggNOG" id="ENOG5032ZHR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149126_1_0_11"/>
    <dbReference type="OMA" id="WNIVVGF"/>
    <dbReference type="OrthoDB" id="2085550at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="87" mass="9768" checksum="3A1E928BA5A6C96E" modified="2011-06-28" version="1">MPKSQVRKKKVYTPPTDVRPAATAATRKPSPIWLPVTAVSLIVFGIGWLVVYYLSEQEYPVMELGYWNLAVGFGAMVGSLILLSRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9J5</accession>
    <name>F4F9J5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733228.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17355"/>
    <dbReference type="EnsemblBacteria" id="AEB44573">
        <property type="protein sequence ID" value="AEB44573"/>
        <property type="gene ID" value="VAB18032_17355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17355"/>
    <dbReference type="eggNOG" id="ENOG5031Z1P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2072150_0_0_11"/>
    <dbReference type="OMA" id="IGAPFAY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="118" mass="12115" checksum="DF1046938701E93C" modified="2011-06-28" version="1">MNTPIDDLIRSTLTDLAEEAVPMNLTDSAVARARRRRTLTVSVGVAGVVAALMVGTPLALAVSRDAPPSAPADQPPMDFPSPVPISPDPSPPLDHPSPVPISPDPSPPLDPKGPGTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9R4</accession>
    <name>F4F9R4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, asnc family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_23710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734492.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23710"/>
    <dbReference type="EnsemblBacteria" id="AEB45840">
        <property type="protein sequence ID" value="AEB45840"/>
        <property type="gene ID" value="VAB18032_23710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23710"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_1_11"/>
    <dbReference type="OMA" id="DHERAGH"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="18455" checksum="F3EB484736BB17E7" modified="2011-06-28" version="1">MGQETVNGPAVTSATGRSAQLDEVDRRLLDELTRDGRMSIRTLAERVHVSRTNAYARVERLVRDGVITGFAARVAPEPAGLGTSAYIALTIRQNTWREVSAELAQVRYVEHVALLSGEHDVLALVRAPDNATLRDVVLDRVQRISGVLSTRSWLVFEEYDGVNSPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9T8</accession>
    <name>F4F9T8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734516.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23830"/>
    <dbReference type="EnsemblBacteria" id="AEB45864">
        <property type="protein sequence ID" value="AEB45864"/>
        <property type="gene ID" value="VAB18032_23830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23830"/>
    <dbReference type="eggNOG" id="COG4106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090249_0_0_11"/>
    <dbReference type="OMA" id="DWRAWQE"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="49"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="27745" checksum="EB7D81FDE3A155DA" modified="2011-06-28" version="1">MSTYISDIDAWQESWDRQQEAYLPDREQRFAAMLDAVDAIRDTAPPRLLDLAGGTGTISLRALRRFPDAELTLVDLDPALLALATATLGDRARIVTADLGRPDWHTALPHRHYDAVLTATALHWLPAERLADLYAEVRDLLRPGGLLVNADHMPDDGLPGLTGRLLARARQRRTARHAAGAALSWSQWWQQAEQDEALGPLVRQRQAIYPTGHSPEWNPPASWHLAALSAAGFTEVGTLWRAGPDAAVVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA14</accession>
    <name>F4FA14_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735771.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00205"/>
    <dbReference type="EnsemblBacteria" id="AEB47125">
        <property type="protein sequence ID" value="AEB47125"/>
        <property type="gene ID" value="VAB18032_00205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00205"/>
    <dbReference type="HOGENOM" id="CLU_207877_0_0_11"/>
    <dbReference type="OMA" id="VFSPWHA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="62" mass="6022" checksum="656A8BF95431BC9F" modified="2011-06-28" version="1">MVGSATARELLLVVAMAVVGLLLATVAAFTPWPVTPGGSAPSSLVDLQGPPVPPEPVGSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA47</accession>
    <name>F4FA47_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735803.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00370"/>
    <dbReference type="EnsemblBacteria" id="AEB47158">
        <property type="protein sequence ID" value="AEB47158"/>
        <property type="gene ID" value="VAB18032_00370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00370"/>
    <dbReference type="eggNOG" id="COG2154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164085_0_0_11"/>
    <dbReference type="OMA" id="GHTQICL"/>
    <dbReference type="OrthoDB" id="1827833at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="107" mass="11877" checksum="4FC472DAA74EC167" modified="2011-06-28" version="1">MRALFGGRAKHDYLSDALTLLNGWTREGEQIRRTLVIDDTQHAALTERVKVVADALHLRPEISRRADHTQIRVGHSNSPLSEGEVLLAARIEDAYRAVAEPDGGRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA96</accession>
    <name>F4FA96_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_05155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730831.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05155"/>
    <dbReference type="EnsemblBacteria" id="AEB42157">
        <property type="protein sequence ID" value="AEB42157"/>
        <property type="gene ID" value="VAB18032_05155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05155"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042787_0_0_11"/>
    <dbReference type="OMA" id="AKHYWVA"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024026">
        <property type="entry name" value="3'-RNA_MeTfrase_Hen1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024740">
        <property type="entry name" value="Hen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038546">
        <property type="entry name" value="Hen1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="PTHR21404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12623">
        <property type="entry name" value="Hen1_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04074">
        <property type="entry name" value="bacter_Hen1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hen1_L" evidence="8">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="473" mass="51920" checksum="094E5526998D0282" modified="2011-06-28" version="1">MLLTLTTTHRPATDLGHLLVKHPDRTHAFDVPVGTAHVFYPQADEARCTAALLLDVDPTKLATARGRGRGRQPTATPESFTLGRYVNDRPYAASSLLASALSRVYRSALRGESRDRPELAATSIPLEIRVPVLRCRGGAEVATRLFGPLGWTVTATAITLDEQHPQWGESRYIDLTLTGTLRVADALNHLYVMLPVLDDAKHYWVAPDEVDKLLRVGAGWLAGHPERGLIVRRYLAHRRALAGQALERLAAQCPTDEPGVDDGVADRPAQAPRASLAARRREAVHTALVEAGAQRVLDLGCGGGALLATLIGDRRFTEIVGTDVSTQALSLAARRIRLDRLPERQRNRVTLHQSALTYRDERLRGYDAAVLMEVIEHLDPPRLPALEDAVFGYARPATVVLTTPNVEHNVRYEGLAAGAFRHSDHRFEWTRAEFAEWVDRVSATYGYSAVVRGVGDDDPQVGAPTQLAVFTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAE1</accession>
    <name>F4FAE1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732039.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43368">
        <property type="protein sequence ID" value="AEB43368"/>
        <property type="gene ID" value="VAB18032_11250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11250"/>
    <dbReference type="eggNOG" id="COG3021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052333_1_0_11"/>
    <dbReference type="OMA" id="AWFIEPY"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="34542" checksum="57051952240CFF67" modified="2011-06-28" version="1">MKITDAGRRRIGTAICWFAVAPGAGWALARVAGLDRGPLVQLLAFTPYALLGTLVPLLLALALRRRWPAVVAAVVTTTLVAVVAPRALPSTQPAVTGPTVRLLTANLLAGAADPATVVDLVRTERVDVLVVQEFTPSAQAELDRLGLDRLLPYRHLNPVVGTPGSGLYARHPISGGGIRTLRGGWGFTQAYATVAVPGAPEVRVESAHPAAPYALDQTGHWRTDLAAQPPATPQGALSVLAGDFNATLDHGPLRALLRTGYVDAAAAVGAGLVGTWGPYDGDRIPPVTIDHVLVDRRIAVRDVSVRPLPGSDHRMILAELALPHALPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAM4</accession>
    <name>F4FAM4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17685"/>
    <dbReference type="EnsemblBacteria" id="AEB44639">
        <property type="protein sequence ID" value="AEB44639"/>
        <property type="gene ID" value="VAB18032_17685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17685"/>
    <dbReference type="HOGENOM" id="CLU_2921496_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="6069" checksum="AF5B70ED4AE96B9D" modified="2011-06-28" version="1">MGQSSGHEGQYPCRRGVACVEVVHGAQQRAVVGGFGEQSEDGVGEDELVAVGAALAGQGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAM6</accession>
    <name>F4FAM6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17695"/>
    <dbReference type="EnsemblBacteria" id="AEB44641">
        <property type="protein sequence ID" value="AEB44641"/>
        <property type="gene ID" value="VAB18032_17695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17695"/>
    <dbReference type="HOGENOM" id="CLU_2482433_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="87" mass="8969" checksum="768F5F4FFC333065" modified="2011-06-28" version="1">MWQCAGRVGDVVQKRVGPLGLSRLPGVAGRGDLPGGGERRVVAEFGGSGQRGRGHRPVLVGLCCVLQLGGQRRIISVGCRGPVQGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAT0</accession>
    <name>F4FAT0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733350.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17965"/>
    <dbReference type="EnsemblBacteria" id="AEB44695">
        <property type="protein sequence ID" value="AEB44695"/>
        <property type="gene ID" value="VAB18032_17965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17965"/>
    <dbReference type="eggNOG" id="COG3423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059166_0_0_11"/>
    <dbReference type="OMA" id="ACPSTVW"/>
    <dbReference type="OrthoDB" id="701032at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="20575" checksum="54943A854A5DE843" modified="2011-06-28" version="1">MLWPEIIRRAAKVGTDRELVGMYPRRADLPRAVFREAIERAQSRIWFGGYTSYFVWLEVPDAATTLAAKANAGADLRFLLGDPDSPITAERDRLEATPLTLATRIAMTRAEIGKVDAAVPVRLSDRHIAMSVWVFDDEAIVATHIGSGLGQDSVTLHLRRTQGGGVFDRYVEHFASLWADGKPADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB10</accession>
    <name>F4FB10_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amphi-Trp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734625.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24375"/>
    <dbReference type="EnsemblBacteria" id="AEB45973">
        <property type="protein sequence ID" value="AEB45973"/>
        <property type="gene ID" value="VAB18032_24375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24375"/>
    <dbReference type="eggNOG" id="ENOG5032CJU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2332835_0_0_11"/>
    <dbReference type="OMA" id="QVNCELE"/>
    <dbReference type="OrthoDB" id="2208186at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20068">
        <property type="entry name" value="Amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amphi-Trp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="98" mass="10652" checksum="668D8192BD8DEB7D" modified="2011-06-28" version="1">MDIYEDERTVSRADLAAWLRQVANQLETGQIFYGAAGTLAVADQVNCELEIEQEGKDEYSVEIEFSWTNPKAAPAAEPVAEKAAEADSADEEPTTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB15</accession>
    <name>F4FB15_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734630.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24400"/>
    <dbReference type="EnsemblBacteria" id="AEB45978">
        <property type="protein sequence ID" value="AEB45978"/>
        <property type="gene ID" value="VAB18032_24400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24400"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="OMA" id="PWLRYRN"/>
    <dbReference type="OrthoDB" id="871215at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="214"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="307" mass="33376" checksum="AC5F1623ECDF0C99" modified="2011-06-28" version="1">MGRVVFLLLPQLHLLDLAGPAQVFSAAADSGLDYRQSFVAESSEVVTAQGLPVRADVDWPDLDPADLVVVPGWRSPASRAEPAQPATLRRLVAHHAAGGTVVSVCGGAYLLGRAGLLAGRRCTTHHELQDELARRYPAATVLNDRLYVVDDRVATSAGIASGIDLALHLMAVRHGPALAARIAREMVVYARRNGHERQDSAMLRYRSHLSDVVHRVQDVIDERFTEALPLVELAGVARVSERTLTRLFDASTGLTPLRYQQLLRVERAEHLIGHGVAVEAAARAVGFTDARMLRRLRARARSTHSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBC0</accession>
    <name>F4FBC0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730889.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05450"/>
    <dbReference type="EnsemblBacteria" id="AEB42216">
        <property type="protein sequence ID" value="AEB42216"/>
        <property type="gene ID" value="VAB18032_05450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05450"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_2_2_11"/>
    <dbReference type="OMA" id="HDGFGDR"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313757" evidence="2">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="75"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="28068" checksum="56E553E8B89161C2" modified="2011-06-28" version="1">MRPRLLLACLTGLTLLLSGCGAGSAEPNPTPADAPPSAALPDPPAPPSPTASPKPKLRPLPAKLPAGLVRTTGGKKVALTFDDGPDPAWTPKVLDLLKAAKVKATFCVVGTQVRKHPELVRRIAREGHQLCNHSWNHDLNLARRPVAEIRADLTRTNREIRRAVEDAKVPYYRQPGGRWTAEVVKVAKQLEMRSLHWTVDPQDWARPTAATIQKRVQRAARPGSVVLLHDGGGNRAATLAACPKVIAALKRDHGITRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBC6</accession>
    <name>F4FBC6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly-gamma-glutamate synthesis protein involved in capsule biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05480"/>
    <dbReference type="EnsemblBacteria" id="AEB42222">
        <property type="protein sequence ID" value="AEB42222"/>
        <property type="gene ID" value="VAB18032_05480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05480"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038823_6_0_11"/>
    <dbReference type="OMA" id="NNHARDQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="54"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="396" mass="42432" checksum="68F9F47A144DED2D" modified="2011-06-28" version="1">MSGPLRAILGSVTALTVAAGAIYVFGPWSSEEPAPIGTPRPVAAAAKVSGRTISVIGSGDILVHPELWDQARRDGAGNLDFGPMLEHVRETVSAADLALCHLETPVAPPGGPYIGFPKFSVPREIVQGIKAAGYDGCSTASNHTIDQGMEGVKRTLDALDEAGLGHTGSYRTKRGAGAAKIYEVKGVKVGHLSYTKSYNGLRPPAGKEWVSNLIDPQAIRREAAAARQSGAEIVLVSLHWGTEYEHEPDVDQQTWAREVAEIDDVDLVFGHHAHVVQPVERIGDTWIVYGMGNHIARHAQPVNTNRDGVMVRAVFGPAGDTNRWKVVAMEAVPTFVDLNPDIRLVDLERKLADVALPPGRRMIYEAAVDRIEGSLLTRGADTEGLIVRGARPGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBF6</accession>
    <name>F4FBF6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05630"/>
    <dbReference type="EnsemblBacteria" id="AEB42252">
        <property type="protein sequence ID" value="AEB42252"/>
        <property type="gene ID" value="VAB18032_05630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05630"/>
    <dbReference type="eggNOG" id="ENOG5032DXS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210342_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="59" mass="6672" checksum="8BA18EDCF48E71E3" modified="2011-06-28" version="1">MKDDQEHTILAVHVRGLDGMCAGCRAWWARLAPYPCWQVDWATSRQARASVARFLGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBL2</accession>
    <name>F4FBL2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732143.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11800"/>
    <dbReference type="EnsemblBacteria" id="AEB43474">
        <property type="protein sequence ID" value="AEB43474"/>
        <property type="gene ID" value="VAB18032_11800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11800"/>
    <dbReference type="eggNOG" id="COG2839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109297_3_1_11"/>
    <dbReference type="OMA" id="WAAVLWW"/>
    <dbReference type="OrthoDB" id="1944975at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007403">
        <property type="entry name" value="DUF456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04306">
        <property type="entry name" value="DUF456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="166" mass="16734" checksum="46A7C54411CA4134" modified="2011-06-28" version="1">MSLTETGAVVSVITALAILAGLAGVVVPGLPALPLCWGGVLVWALFGEAGAGRWLVLAAATVVALGGTVVKYLWPGRNLKRAGVPTATLLVGALLGLVGFFVIPVVGLIIGFVVGIFLMERLRLGDTGLAWPATKQAVAAAGLAMLIEFLAGVVIGALWVAGLVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBM0</accession>
    <name>F4FBM0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11840"/>
    <dbReference type="EnsemblBacteria" id="AEB43482">
        <property type="protein sequence ID" value="AEB43482"/>
        <property type="gene ID" value="VAB18032_11840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11840"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129336_1_0_11"/>
    <dbReference type="OMA" id="EWKISAF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="161" mass="17988" checksum="A2400F796C30A05C" modified="2011-06-28" version="1">MDDRQIRDLFDRLMRAWTDNDAAAYGACFTDDSDYVSYDGTRAVGRHDMQDAHDRLFRGVLAGSALVGDIESIRYVVPGVAIVHGTASVLMPWRSRLPRRRLSRQTLVAVRTDQGWRFTALHNGRVRPVQIPAPDSLPSRMSQAMGHAARRLGMGRAAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBR0</accession>
    <name>F4FBR0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733365.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18040"/>
    <dbReference type="EnsemblBacteria" id="AEB44710">
        <property type="protein sequence ID" value="AEB44710"/>
        <property type="gene ID" value="VAB18032_18040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18040"/>
    <dbReference type="eggNOG" id="ENOG50332TT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2207266_0_0_11"/>
    <dbReference type="OMA" id="EMPHLMG"/>
    <dbReference type="OrthoDB" id="1788762at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006765">
        <property type="entry name" value="Polyketide_synth_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038474">
        <property type="entry name" value="Polyketide_synth_cyclase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04673">
        <property type="entry name" value="Cyclase_polyket"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="106" mass="12274" checksum="2051B802BCC745E5" modified="2011-06-28" version="1">MAQRTLIIARMDEADKQAVADIFAESDATDLPVLLGASRRTLFFYRGLYLHLIEAQDGLTERLYDARRHRLFDDVNTKLSAHISPYDPGWKEPRDAMAEPFYTWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCC6</accession>
    <name>F4FCC6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplX</name>
        <name evidence="6" type="ordered locus">VAB18032_01105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01105"/>
    <dbReference type="EnsemblBacteria" id="AEB47305">
        <property type="protein sequence ID" value="AEB47305"/>
        <property type="gene ID" value="VAB18032_01105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01105"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_0_11"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="106" mass="11436" checksum="401BC8E210443FED" modified="2011-06-28" version="1">MTVKVKKGDTVVVIAGKDKGAKGKVIAAYPRQDKVLVEGVNRIKKHTRISTTQRGAKTGGIVTQEAPIHVSNVMVLDSDGKPTRVGYRIDENGQKVRIARSTGKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCG9</accession>
    <name>F4FCG9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD linked oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05850"/>
    <dbReference type="EnsemblBacteria" id="AEB42296">
        <property type="protein sequence ID" value="AEB42296"/>
        <property type="gene ID" value="VAB18032_05850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05850"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_0_1_11"/>
    <dbReference type="OMA" id="WGYTGNA"/>
    <dbReference type="OrthoDB" id="295054at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="42"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="453" mass="46870" checksum="7BD9A00178B75536" modified="2011-06-28" version="1">MYDRGMVPARSTGTSGALDITRRLIEICGPRFARFAGPADEVAGRPARWVAVPGGADAAARVLRLAARHDLSVVPRGAGTKIDWGAPPERVDIMLDTGRLAGIGHRPPGQGAAEVGAGTPLRAVQATLERTSQRLAVDAPSPGATIGGVLAADEAGPLRHRHGTACDQLVSLRYLAADGELTEADGGAAGLAQARLLCGSEGALGVLVSATLRVQAMPACRVWVTRPVWTPLEVHDLIRAVLAARLDPAAIELDLPVGGKDRMPWDARAAAMARHPSMTGRSPASPAGAGSLVVLLEGGPSDVAERSDRLVSLLGARATVARSAPPWWRSYPFAPGDTALRLEVPITDLHAAVYALRDAAGSPVPVRGSAGRGVVHAALPGSLAPDRVAAILAAVRSVLLARQGRCVVLSAPPAVRRAVDLWGELVGLARLRAVKQHLDPGHRLAPGRLPGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCM7</accession>
    <name>F4FCM7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732190.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12035"/>
    <dbReference type="EnsemblBacteria" id="AEB43521">
        <property type="protein sequence ID" value="AEB43521"/>
        <property type="gene ID" value="VAB18032_12035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12035"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_2_11"/>
    <dbReference type="OMA" id="QTWREAY"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="183" mass="20396" checksum="D0F8B1EAAE7911EE" modified="2011-06-28" version="1">MPTIRREQATDAEAIARVHISGWRAGYAGIMPDEVLARLNPVAWAQRRRDLGTAEPEHPFTTLLAEIDGVLAGFTTFGPYRNNQDRGDLDPAYGEVVAMYVAPQHWGDGTAKALFAAARAGLRDRGWTQYRVWVLADNHRARRFYERAGLSPDGERSTYQVPLSGGRTPLGLVELRYTGRLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCU3</accession>
    <name>F4FCU3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">miaA</name>
        <name evidence="9" type="ordered locus">VAB18032_12365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12365"/>
    <dbReference type="EnsemblBacteria" id="AEB43587">
        <property type="protein sequence ID" value="AEB43587"/>
        <property type="gene ID" value="VAB18032_12365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12365"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_11"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="33158" checksum="05B70BFD79A057D8" modified="2011-06-28" version="1">MTPGTVLAVVGPTAAGKSALSIALAHALDGEVVNADSMQLYRGLDIGTAKLTVAERDGVPHHLLDIWEVTEPASVAEYQALARAAVDDILARGRVPLLVGGSGLYVRAVLEQFEFPGTDPALRARLENELATVGPAPLYARLREADPVAAAGILPGNGRRIVRALEVIELTGAPFTAALPEPTPYYPAVQVGVDLDTARLDERIAVRVDRMWADGLVAETRRLVERGLPEGRTASRALGYQQVLRMLSGELTETEARDDTVRATRRFVRRQRSWFRRDPRIHWLDSAEPTLVEDALRILRDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCV6</accession>
    <name>F4FCV6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18430"/>
    <dbReference type="EnsemblBacteria" id="AEB44788">
        <property type="protein sequence ID" value="AEB44788"/>
        <property type="gene ID" value="VAB18032_18430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18430"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049031_0_0_11"/>
    <dbReference type="OMA" id="TWALMRE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="34684" checksum="509712F1C0358557" modified="2011-06-28" version="1">MPIERADGLTAVVYGQVERDFGMLAPPVSLHSPAPPVLAACWIVLRETLVAAGRVDRATREAVAAAVSTVNSCPYCVEVHSATMAGLLRSAADPAGDDQRRRVAEWARAGTDRTQARDLVPPVPAVEAVELLGVALVFHYLNRMVNVFLEPSPLPAALPSALRGGVRRVFGQLMARGARGDRPPGTARDLLPAAPLAPDLAWSSCHPTLADALARGGAAIDAAGQRSVPTSVRDLVAARLDDWDGRPTGISRAWVGEAVRDLPTVDQPAARLALLTAFASYQVDDQVVADVRAAGADDRALVELTAWASMAAARRAAGWVRVDPDAPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCV8</accession>
    <name>F4FCV8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ASPIC/UnbV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18440"/>
    <dbReference type="EnsemblBacteria" id="AEB44790">
        <property type="protein sequence ID" value="AEB44790"/>
        <property type="gene ID" value="VAB18032_18440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18440"/>
    <dbReference type="eggNOG" id="COG4658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432058_0_0_11"/>
    <dbReference type="OMA" id="MDLLVYY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309251" evidence="2">
        <location>
            <begin position="34"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="UnbV_ASPIC" evidence="3">
        <location>
            <begin position="566"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="647" mass="69587" checksum="FA9CEAC8AB4D4313" modified="2011-06-28" version="1">MTIGLLRRQLAGIIGLALVVGMFFAVRLPSASAAERTELASRYAFEPMGIALPASKHQQTVRKVNQTYTHIDAWISSVGAGIAMNDLDGDGLANDLCITDPRTDQTIVTPTPGLGEQRYQPFALDAAPLPISRITAPMGCAPGDFNEDGRMDLLVYYWARTPILFLNNGKELSSGTAAYRPVELVPGVGVGEYNGPLWNTNAVAIDDFDGDGHVDIYVGNYFPHSPVLDDTVKGGVEMNDSMSYGLNGGEDYVFRFTEGTGGAEPTAVFQRVDNVIPHSASKGWALAAAAVDLDGDLLPELYLAHDFGPDRLLYNRSTPGNIEFALVQGARSATIPKSKVLGRDSFKGMGADFGDIDGDGLYDLFVSNITTPFGIQESNYTFMNTAADQSGVKTAFSSGKAPFRDRSADLGLAWSGWGWDVKMADFDNGGRLAIAQATGFVRGEVNRWPQLQELATTNDTLVRHTSWWPNVRPGDDIGGSQRLHFFVEGKDGRYVNIAPELGLDIPLPTRGIATGDADGDGRLDMAVARQWAEPIFYRNTSPDAGAFLGLRLTHETADPATTGSPAVGAQVMVTTPDGRKFVSRVDGGGGHSGKRSNEVHIGLGAEVTGSVQVTLCWRDRTGQIRKQDLQLTPGWHDVQLGSQANER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCZ3</accession>
    <name>F4FCZ3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, laci family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44825">
        <property type="protein sequence ID" value="AEB44825"/>
        <property type="gene ID" value="VAB18032_18615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18615"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="CVAVDFR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="384" mass="40968" checksum="9529D2A6F1F84A77" modified="2011-06-28" version="1">MIENSGRAWPDRERPAPSALARGNEAERPVRASGRSIMRDVAELAGVSAQTVSRVINGHPYVADHTRQRVLDAMRRLDYRLNPAARALVTRRSGTLGIVGYESPLYGPTSMLYAIEGAARAAGYFVSVASLRHLDRRSVFEAVDWLRRQSVEGLIAIAPKPAMADALAEASSGLPAVTVGGGCTEAVSSAQIDNVEGARLATRHLLNLGHTTVHHLAGPQDWPEARERVAGWHAALRAAGAPTPAVVPGDWSAGTGYEQGERLARDRSVTAIFCASDQLALGVLRALHEAGRRVPGEVSVVGFDGTADGAHFLPPLTSVRQDFAELGRRSLRLLLEQLDRPASGSRPRRDVLVPELVIRRSAAAPCDDDHAAADLTLSGPSRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD35</accession>
    <name>F4FD35_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,3-dihydroxybenzoate-AMP ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734717.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24835"/>
    <dbReference type="EnsemblBacteria" id="AEB46065">
        <property type="protein sequence ID" value="AEB46065"/>
        <property type="gene ID" value="VAB18032_24835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24835"/>
    <dbReference type="eggNOG" id="COG1021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_11"/>
    <dbReference type="OMA" id="YTIRGYW"/>
    <dbReference type="OrthoDB" id="1015470at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="456"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="545" mass="58391" checksum="994E81C663730EE0" modified="2011-06-28" version="1">MNPSGVVPWPTEVAQVYRAAGCWRGRPLGSYLWEWAERHGDRIAVVDGDRRLSYHELAVRTDQLAERLAGLGLGRGDAVLVQLPNCAEFVLTTLACFRLGVVPVMMLPPHREYELTAIGAHVEARALIVPARWRDYDHEALAHRVVAAWPHPAHVLVAGGDTVPGRIDLCGPATPPGDVAARRDRLDRAAPDSAEVALFLLSGGTTGVPKVISRTHDDYEYNIRQVVAACEFGPDTVYLTVLPAGHNFPLANPGILGTLSVGGRVVLLPSPRPEAVFAAIERERVTVTSAVPAVALRWMEAAADCGYDLSSLRHVQVGGSPLAPEVAARIGPALGCRLQQVYGMAEGLICYTRPDAPDEVAHRTQGTPISEYDELLIVDADGVAVPSGQIGELWTRGPYTPRGYYGVPAQNAESFTPDGWYRTGDLVRRTPGGEVVVCGRVKDLINRGGEKISAAEVETLVQELPAVAEAAVVPVADPEVGERAFLFVRLLPGHELGLADVAEAFAARGVAAFKVPERLAVLDELPHTPVGKPDKAALRRLVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD38</accession>
    <name>F4FD38_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734720.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24850"/>
    <dbReference type="EnsemblBacteria" id="AEB46068">
        <property type="protein sequence ID" value="AEB46068"/>
        <property type="gene ID" value="VAB18032_24850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24850"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129336_1_1_11"/>
    <dbReference type="OMA" id="GFAGPFK"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="16333" checksum="EB3DD72520156206" modified="2011-06-28" version="1">MPTSTESALDAYYGSFTSEREKAALSVPLRLVAAWAKNDADGVAAVFTPDGSMILPGDVYKKGRDEIRAFMAAAYAGPFKGTGVTGAPVDVRLINDDVALLRTHGGILAPGETEIAPELAVRSTWVVVKRDDQWYLASYQNSPRGEGATLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDB0</accession>
    <name>F4FDB0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734792.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25210"/>
    <dbReference type="EnsemblBacteria" id="AEB46140">
        <property type="protein sequence ID" value="AEB46140"/>
        <property type="gene ID" value="VAB18032_25210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25210"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074041_0_0_11"/>
    <dbReference type="OMA" id="DDTLWVN"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="26361" checksum="2332F7519E179070" modified="2011-06-28" version="1">MGIEPGRVLVFDADDTLWENNVVFERVIDDFLAWLDHPTLDRVQLRAVLDDIERANAVAHGYGSKVFLRSLRECLERLRQRPATAAEQREIDELAVALVNHQVELMPGVADALDELAGRHELLLLTKGEREEQQRKLDACGLLHHFRAAHIVAEKNVETYRWLVREHAIDPARAWMIGNSPRSDILPARAAGWRAVFIPNANTWVLEHDELDPADEGVLHLSTFPELLRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE06</accession>
    <name>F4FE06_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18865"/>
    <dbReference type="EnsemblBacteria" id="AEB44875">
        <property type="protein sequence ID" value="AEB44875"/>
        <property type="gene ID" value="VAB18032_18865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18865"/>
    <dbReference type="eggNOG" id="COG3544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074343_1_0_11"/>
    <dbReference type="OMA" id="KLMITHH"/>
    <dbReference type="OrthoDB" id="1714516at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307834" description="DUF305 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="80"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="24541" checksum="9513C6535674BDF6" modified="2011-06-28" version="1">MLVELAVLAVLAVGAAVLFLQPEDTSEPAATASPTQAIELPGLPDSTAPVLLPGRPGETARTAPANEVSALPRQPHNNADIRFVTMMIPHHEQALVMARLVPDRGENEQLKRIAERMLAAQEPEIKFMENWLAERGLDRNSGGDHRHTMSGMQSAEALNRLTAARGADFDRMFVVMMTEHHEGAIKMANEALVLGSEPLINEMASSVVVEQNVEINRMREALASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE54</accession>
    <name>F4FE54_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733578.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19105"/>
    <dbReference type="EnsemblBacteria" id="AEB44923">
        <property type="protein sequence ID" value="AEB44923"/>
        <property type="gene ID" value="VAB18032_19105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19105"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_2_2_11"/>
    <dbReference type="OMA" id="TRSAQDC"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="61"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="412" mass="44249" checksum="117A12231AF5AFFA" modified="2011-06-28" version="1">MHRATEQVLVNLALYDGVADHLQADQGIWIGVDGMIRAVGPVDDVLAEAGDVPVVDLGGDVVMPGLTNMHVHLSLGLPGHLADEVHRSNLAELVLLMADSARRTLHAGVTTARLVGEGRYADFALRKGIEAGAVDGPRIFTAGHALCCTGGHGWEADALEADGADGFRQLTRAQIRAGADLIKVCISGGIAGQYEAIDTPQLLDDEMAAVIRVAHDWGRKVTAHAGPADTVRRAVELGLDCVEHGYELTDEVTRLMAERGVWYVPTIVVSRCEQFFRDSGVPGWLMERALGAGPRHWESLQHAIRNGVPIALGSDMPPHAGYDETTATVRELEFMVDAGMPVADALKAATIRPAEWLNADDKLGSITAGKHADLLVLRDDPTRSVSALRTLHVVMKGGVVYRDDHGRTRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FED8</accession>
    <name>F4FED8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ordered locus">VAB18032_25530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734856.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25530"/>
    <dbReference type="EnsemblBacteria" id="AEB46204">
        <property type="protein sequence ID" value="AEB46204"/>
        <property type="gene ID" value="VAB18032_25530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25530"/>
    <dbReference type="eggNOG" id="COG1859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_4_0_11"/>
    <dbReference type="OMA" id="YLYHGTV"/>
    <dbReference type="OrthoDB" id="1893705at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="19421" checksum="756362CF0A08ABBB" modified="2011-06-28" version="1">MTDRLTSTSKFLSYVLRHRPDAVGVTLDEAGWVPVDVLLAALARHGRPVTPALLDQLVGNTDKQRFEVREGRIRAAQGHTIAVDLQLAPAVPPTVLYHGTVARFLPGIRVEGLTSGERTHVHLSSDLDTAARVGARRGKPVVLRIDAAGMHVAGLVLYRAANGVWLTRHVPPRFITLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEI8</accession>
    <name>F4FEI8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase a2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736065.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="SMR" id="F4FEI8"/>
    <dbReference type="STRING" id="263358.VAB18032_01730"/>
    <dbReference type="EnsemblBacteria" id="AEB47430">
        <property type="protein sequence ID" value="AEB47430"/>
        <property type="gene ID" value="VAB18032_01730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01730"/>
    <dbReference type="eggNOG" id="COG5479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053014_2_0_11"/>
    <dbReference type="OMA" id="FDWSTDY"/>
    <dbReference type="OrthoDB" id="1798405at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307850" evidence="1">
        <location>
            <begin position="29"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="178" mass="19656" checksum="16391E30A85BE845" modified="2011-06-28" version="1">MLKRLATLLTSGILALLTAFATASPAAAAVTPAQKLSVLSSWTQTSVSSYNAWNSARQNRAAWAEYKFDWSTDYCSSSPDNPLGFNFSLSCFRHDFGYRNYKAVGQFSANKSRLDSAFYEDLKRVCATYNSVVRPACTSLAWTYYQAVSIFGSVAAVEQADIDRAARMKADAERHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEP8</accession>
    <name>F4FEP8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06590"/>
    <dbReference type="EnsemblBacteria" id="AEB42442">
        <property type="protein sequence ID" value="AEB42442"/>
        <property type="gene ID" value="VAB18032_06590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06590"/>
    <dbReference type="eggNOG" id="ENOG5033IM2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150710_2_0_11"/>
    <dbReference type="OMA" id="WLWICLA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="80" mass="9040" checksum="96A25D31C39472F8" modified="2011-06-28" version="1">MPKQQPRPEPLDPPMVPFALAGIVAWAVAGLVLLLFRDRLAASGHEDWLWICLAGFLWGFPGLAVMMRHDAHRRRRRAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FES3</accession>
    <name>F4FES3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731140.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06715"/>
    <dbReference type="ESTHER" id="verma-f4fes3">
        <property type="family name" value="DLH-S"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42467">
        <property type="protein sequence ID" value="AEB42467"/>
        <property type="gene ID" value="VAB18032_06715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06715"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082991_0_0_11"/>
    <dbReference type="OMA" id="LFEEPGK"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="83"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="222" mass="22949" checksum="F0849C2C88B049ED" modified="2011-06-28" version="1">MDVRGNAVTIPAGGADLPADLLIPAQPVGAVLFAHGSGSSRHSPRNLAVARSLSAGGLGTVLVDLLTPAEAEADAVTAELRFDIDLLSRRLAAIVDWLVSEQPFDTARIGIFGASTGAAAALVAAARRPEQVYAVVSRGGRPDLAGTALGQVRAPTLLLVGGLDEPVISLNRHALDQLTAPADLRVIPGATHLFEEPGTLEQVAEAAADWFHDHLHPQLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FET8</accession>
    <name>F4FET8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_06790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731155.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06790"/>
    <dbReference type="EnsemblBacteria" id="AEB42482">
        <property type="protein sequence ID" value="AEB42482"/>
        <property type="gene ID" value="VAB18032_06790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06790"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_5_11"/>
    <dbReference type="OMA" id="QATCVRA"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="123"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="20625" checksum="D48754EDEC4321D3" modified="2011-06-28" version="1">MTAATDETTGYAFAAGRGDQAAAAAFVRATQHDVHRFLAHLPGVRDVDDLVQETYLRAWRALPSFAGRSTARTWLLAIARRVAVDQVRAAAARPRTANLADWQAAAEATSAGVRAGVDDEVVLYRMLDGLTSDRREAFVATQLLGLSYAEAAQVCDVPVGTIRSRVARAREDLVAAMRPATRRRGAHPDAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEV7</accession>
    <name>F4FEV7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_06885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731174.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06885"/>
    <dbReference type="EnsemblBacteria" id="AEB42501">
        <property type="protein sequence ID" value="AEB42501"/>
        <property type="gene ID" value="VAB18032_06885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06885"/>
    <dbReference type="eggNOG" id="COG4149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_1_11"/>
    <dbReference type="OMA" id="MYSFIET"/>
    <dbReference type="OrthoDB" id="1915735at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="64"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="275" mass="29088" checksum="986AEF4A8D38D03E" modified="2011-06-28" version="1">MRRVDSGTAPARRIGRVRRVPVALLLPAAIGLLFLLLPLVGLLARTPWATLPQRLTEPGVLTALRLSVQTATLATLLCLVLGVPLAWLLARVPFPGRRLVRALVTVPLVLPPVVGGVALLLVFGRRGLVGSWLDETFGITVPFSTTAVVLAQTFVAMPFLILAVEGALRGADTRYEEAAATLGAGRWITFTHVTLPMVAPGVAAGAVLGWARALGEFGATITFAGNYPGRTQTMPVAVYLALETDLEAAIVLSLVLLTVSVVILASLRDRWVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEY8</accession>
    <name>F4FEY8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_12930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732368.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12930"/>
    <dbReference type="EnsemblBacteria" id="AEB43700">
        <property type="protein sequence ID" value="AEB43700"/>
        <property type="gene ID" value="VAB18032_12930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12930"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OMA" id="THILVTY"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="322" mass="36471" checksum="4D8321C77CF9BEE2" modified="2011-06-28" version="1">MSLSATTAPPSSAPPPPNAEPRRRRGHLLNRLDLKYSPYLYIAPFFLIFGVFGFYPMLRTAWMSLHDWDMIGENSFIGFDNYTRLISDEYFWNALVNTFGIFALSTIPQLLLALFLANLLNRTLLRAKTFFRMAIFIPNVVSVAAVAIVFGMLYQRDFGLFNWLLSFAGVEAIDWNGEKWSSWTALATMVNWRWTGYNTLILLAGMQAIPKDLYEAAAIDGAGQWRQFWQITLPMLKPTFIFVVILSTIGGMQLFTEPLLFANGNIIGGDQRQFQTLAMYMYEMGIVNLNTAGYGAAVAWAIFMIIVLVSLINFVLVRRTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF40</accession>
    <name>F4FF40_MICM1</name>
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        <recommendedName>
            <fullName evidence="1">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ordered locus">VAB18032_19215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19215"/>
    <dbReference type="EnsemblBacteria" id="AEB44945">
        <property type="protein sequence ID" value="AEB44945"/>
        <property type="gene ID" value="VAB18032_19215"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG5032Z9W">
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    <dbReference type="HOGENOM" id="CLU_174720_0_0_11"/>
    <dbReference type="OMA" id="RICKHMN"/>
    <dbReference type="OrthoDB" id="1919863at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="104" mass="11131" checksum="C8DB176E1D84B67F" modified="2011-06-28" version="1">MSAANPFPPEVVAAVMRHMNTDHADDCRVICQGLGSQPTATAAAMSGMDADAMEFLAVVDGVEVPVRVPFSSRIAERRQIRAEAARMYREACAALGRTPRPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFJ7</accession>
    <name>F4FFJ7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_26005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734950.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26005"/>
    <dbReference type="EnsemblBacteria" id="AEB46299">
        <property type="protein sequence ID" value="AEB46299"/>
        <property type="gene ID" value="VAB18032_26005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26005"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_7_1_11"/>
    <dbReference type="OMA" id="WFACIVV"/>
    <dbReference type="OrthoDB" id="2057754at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="84" mass="8983" checksum="605C790B2508B18B" modified="2011-06-28" version="1">MPIWFAYTLIVLLVITSFMLVLLILLHRGKGGGLSSMFGGGVSSSLAGSSVAEKNLDRYTVLVGIVWFACIVGLGLWLRLQVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFQ1</accession>
    <name>F4FFQ1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736162.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02220"/>
    <dbReference type="EnsemblBacteria" id="AEB47528">
        <property type="protein sequence ID" value="AEB47528"/>
        <property type="gene ID" value="VAB18032_02220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02220"/>
    <dbReference type="eggNOG" id="COG4339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051795_1_1_11"/>
    <dbReference type="OMA" id="PQRRYHT"/>
    <dbReference type="OrthoDB" id="1086845at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="entry name" value="PTHR21174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="24099" checksum="EB59E27B9007EC65" modified="2011-06-28" version="1">MAGLIERWRTTVRAAGASDPAAIEATGSELLERWREPHRHYHTVDHLTAVLDVVDRYASAGQRPDLVRLAAWCHDAVYDPRAPGDRNERDSAALADTLLTRAGLPGPEVAEVRRLVLLTAGHQVDPADADGVLLCDADLAVLAAAEPEYDRYASAIRREYAHVPPAAYRIGRAQVLTHLLALPGIFRLLEPATRWEPRARANLARELGTLQATDQDVTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFX9</accession>
    <name>F4FFX9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07175"/>
    <dbReference type="EnsemblBacteria" id="AEB42559">
        <property type="protein sequence ID" value="AEB42559"/>
        <property type="gene ID" value="VAB18032_07175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07175"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072327_0_0_11"/>
    <dbReference type="OMA" id="PMDTPNA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="60"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="301" mass="30460" checksum="F153DAD7267BF4AE" modified="2011-06-28" version="1">MTSMPAPPVTAVAVTSYSVHLPADDRFDTAVADLPPVEPGCPADRAHTLLGRKGLLYKEPATRLALCAVHRALGLPDGVRPANALDPRTAVVAASNLGNVATVVDVTRAVAKEGSRGVSPMAAPNASSNVIASSIALWFRFGGPNLMVCSGETAGLDALALGALLLRAGRADRVLVVGAEPDDETAVAVRRGPAADSTTPPLRAGAACVVLEPVTRAAAPLATVTVGPTLSRRVPPPTRIVVGPGHLDPAAAWGDCYGAQGVLQTALAAQLVAEGADGVAVLCGGDDDGWRTALLTPGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG78</accession>
    <name>F4FG78_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13550"/>
    <dbReference type="EnsemblBacteria" id="AEB43822">
        <property type="protein sequence ID" value="AEB43822"/>
        <property type="gene ID" value="VAB18032_13550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13550"/>
    <dbReference type="eggNOG" id="COG1556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090664_0_0_11"/>
    <dbReference type="OMA" id="VPDHHIC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="106"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="205" mass="21620" checksum="24526C68B2F57BA3" modified="2011-06-28" version="1">MVGRAMSSRDLVLGRLRAALAAGGPVASVEVPRDYRHTGPLDLDRFVARLIDYRARVHRVSEDAVADTIAAILPAGATVVVPPGLPSAWLPSTVTVRPDRDLDNGRIAAADAVVTAAAVAVAETGTVVLDGSPDQGRRVLSLLPDRHVCVLRSAQVVATVPEALARLTPRRPLTWISGPSATSDIELDRVEGVHGPRTLHVVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG93</accession>
    <name>F4FG93_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cellulose-binding family ii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_19645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19645"/>
    <dbReference type="EnsemblBacteria" id="AEB45031">
        <property type="protein sequence ID" value="AEB45031"/>
        <property type="gene ID" value="VAB18032_19645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19645"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030937_0_0_11"/>
    <dbReference type="OMA" id="WWNVHNG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307886" evidence="3">
        <location>
            <begin position="22"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="478"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="5">
        <location>
            <begin position="566"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="677" mass="71254" checksum="E86853EB34E4F439" modified="2011-06-28" version="1">MAGLLLATGVVTGVDAPSADAATAPVTVSVNARAGLARVPDTALGVNHAIWDQYLATPETSDLLRDAGVQMMRYPGGSYADIYHWRDHTAPGGYVAPGTDFDTFMGAVRRVGAEPMIIANYGTGTPQEAADWVRYANVTKGYGARYWTVGNENYGNGHYGSAWEADHHPDKSATYYANLVVDYAEAMKAADPTIKVGAVLTMPANWPDGLTAGNDPGPWNQTVLSIAGPSIDFVDVHWYPGGSPAESLPRTSHITDAVYLLRQQITRYAGSQADRIGISLTEVNVTSEGMTSQPAALFLADAYSGLLANGVFTVHWWNVHNGIGRVSTVAGQTDYGDFGLLSSGTCTADGSVCEPPVNTPFAAYHGLSMMSRFARTGDQFIRAETDQPLVSAHAVRRANGEVAVLLINKDPENAHPVTIDYAGFAPASGAPTVHTHTNGATEVTTARSGEATSRTLPPYSLTTLVVRPAAAVTGAPGAPGQPSATGVTDRDVTITWPAATAGAAPIAKYEVHRQNGAVSEQLGETSGTSLTVGNLVPGRRYTVNVLARDTTGRVSWASPPLTFTTGSPATSGCAVRFTSTTDWGNGYVANVDIVNNSEHTIDGWTLTWTWPTSWQRVGSGWSATWEQVGSTVRVTSNDDNRRLSAGASTTVGLVGEYSGPNVVPTAFRLNGTLCTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGD3</accession>
    <name>F4FGD3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733726.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19845"/>
    <dbReference type="EnsemblBacteria" id="AEB45071">
        <property type="protein sequence ID" value="AEB45071"/>
        <property type="gene ID" value="VAB18032_19845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19845"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_1_0_11"/>
    <dbReference type="OMA" id="ENDHQIN"/>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="23113" checksum="675BD686A8C18587" modified="2011-06-28" version="1">MGRDSYDEQLDRLTGILATMSREAGTAIRGASVALLDVDRHAAETVIADDAILARRRAEAEAMIPEVLVRHQPVASDLRLVVCALRIAGALDRMGDLAVHIAKVVLMRHPVGVVPEPAVPVLTEMADAAARIADKATMVLATRDPLDAMQLGLDDDEVDAAQERLLSMLVSGWSYGVESAIDLALVGRYYERYADQAVNVARQVVYLVTGTVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGJ2</accession>
    <name>F4FGJ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_26145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734978.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26145"/>
    <dbReference type="EnsemblBacteria" id="AEB46327">
        <property type="protein sequence ID" value="AEB46327"/>
        <property type="gene ID" value="VAB18032_26145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26145"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036777_0_0_11"/>
    <dbReference type="OMA" id="AWHESGW"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313913" evidence="2">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="156"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="31571" checksum="2848A66B75E345D1" modified="2011-06-28" version="1">MGRNVGRFTVALVAGLLMVTGGACARVDTPAAELPAPVALPEEETQPSSEPAEPSPTPEAVESMGAAPKVSRSPSASPKASASPEPPPKPKRTSTAPRAVPKPPTETKVPPAPPKPAPSSCKPSYKGDQASRAQARAALTDAAGRVYWPTSAPDIRVPVNLIKATGWQESGWQSNIVACDGGIGLMQVMPDTATWMNQRFGQNYDVWDYRDNAYLGGTYLAWLTKYIGDMYFDADYRLDTELCTSELNSCLLNAVIAAYNYGHGAVAREGQPLAIPNPSYVRNVRALMTECVCLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGZ7</accession>
    <name>F4FGZ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731284.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42611">
        <property type="protein sequence ID" value="AEB42611"/>
        <property type="gene ID" value="VAB18032_07445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07445"/>
    <dbReference type="eggNOG" id="ENOG502ZDJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894140_0_0_11"/>
    <dbReference type="OMA" id="HHRAWFT"/>
    <dbReference type="OrthoDB" id="1915270at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="33373" checksum="8579B49126A11D3F" modified="2011-06-28" version="1">MSEHPPHPHHQADHTGPAEATLIDLIAGDPPVPITVWRTARTDADRPTSLPTRLAYRLVAAYSRPGEAVVDLTTDHTLTEICAQGGRRHHRAWFTDSSSLIIGPATAGQPAATTTTSPLTAPVEPRAGDTQEPPELVDWFGDDLTDPDLYGADTAVVRPPDDGPLDEATSLVVASWPLHEADITARVRLAWLLTACARLLRPGGCLVLVAGVPTGTQPTPEDFGPLVAAASEAGLGYLQHIVAVEADTDGDQFVYHVTDEELLSLAHADGEQWQVAHLRVHADLLVFTIPQSPAVPGPRRRRDREGGERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH49</accession>
    <name>F4FH49_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07715"/>
    <dbReference type="EnsemblBacteria" id="AEB42663">
        <property type="protein sequence ID" value="AEB42663"/>
        <property type="gene ID" value="VAB18032_07715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07715"/>
    <dbReference type="eggNOG" id="ENOG5030DNK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077895_0_0_11"/>
    <dbReference type="OMA" id="HCTTAPA"/>
    <dbReference type="OrthoDB" id="1428394at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032564">
        <property type="entry name" value="DUF4928"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16280">
        <property type="entry name" value="DUF4928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="37674" checksum="FE56D6103258B0AC" modified="2011-06-28" version="1">MLKLLAGWGCIMDSDQATAKPIADDLIASLEHWRETKRGKKGTISANVFCAGLYVTEYLGGKYPLQRSDYLADSQVRGASGATAKNILSRHGEDRDFLKEGGRTSRMTKEVAVEIVDLLDKHPRSDDLRRLPLDELAAVARTLQAWFVDQIKVEYFGKQRIKAEFSPTTPMKLVVSALLKSAQERGGNTAGAVAQHLVGAKLALRFPKLEISNDSYTTADVQTSRPGDFLVGDTAFHVTMSPSQPLFEGRCKSNRKAGFRSRVLVPESRLAAAAQLADLARLGDYVAVQSVEDFVGTNVEEMAGFREQEIRSHLRLLLDTYNHRVAGVESDPSLLIELPENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH95</accession>
    <name>F4FH95_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13805"/>
    <dbReference type="EnsemblBacteria" id="AEB43873">
        <property type="protein sequence ID" value="AEB43873"/>
        <property type="gene ID" value="VAB18032_13805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13805"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_2_5_11"/>
    <dbReference type="OMA" id="RIVPAYW"/>
    <dbReference type="OrthoDB" id="1979131at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="374" mass="41786" checksum="6F3789A81C8A2E42" modified="2011-06-28" version="1">MTSAPVAAPPGSATDRALASRLPSLTGLRWIAALLVFGFHAGTMRIIAEPDYQAVVGKVFTLGLSGVQFFFILSGFVLVWSARPGDSRRRFWRRRFAKIYPNHVLLWALAMGAAVWFADPINPVAALENLFLIQAWDPRPGYFYSVNNVSWSLSCELFFYLCLPLVLPLVRRARPWQLWAVVIAVPLLILALWPAQTLVPEQSRWWFTQVFPLVRSLEFWMGVAAAELMLRGRWRGPGLPLASLIFVGTWVAAAEWIRAEFWAALLAAAYVLVIAAAADADVRGRRSPLRSRPMVWLGEVSFAFYLVHVFVIMTILRITGDWGTGLPGWWGPAAVIGFLALTLGLAALVHRFVEQPMMRRLAPRRSPPAVQPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHF0</accession>
    <name>F4FHF0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_20100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733777.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20100"/>
    <dbReference type="EnsemblBacteria" id="AEB45122">
        <property type="protein sequence ID" value="AEB45122"/>
        <property type="gene ID" value="VAB18032_20100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20100"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529605_0_0_11"/>
    <dbReference type="OMA" id="DQAGEYR"/>
    <dbReference type="OrthoDB" id="1863545at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="94"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="508" mass="53167" checksum="8F68891FCB028A8A" modified="2011-06-28" version="1">MRPGSLFRLAFVGTRSDRARVPVTAAGAAIAVLVLLCCATVLSIESAAGRYHNRMLTQPGLLLNVAVAMLLCSIPILFLVAQCARLGAPARNRRLAALRMAGATPRQITWVAAVETGLAAMIGSVVGVVGYLVGRVLLDRPDPAGVRPLPTDVLPSVTAIVAIAVAVPLLTTLLTVVLLRRVAITPFGVLRQSRQQPVRAWPTLLLGLGLGGLVSISAVMRSEYVRQGGFGANRDDLFVIALLGCTVVMLLGLMFTVAWIGYRSARLLLRVTRRPSALIAARQILADPHAGSRSFTVILVVTAFGAAAMMLHSWLDTEVAVRTAAMLDPALGYDTPPLDLGGTAAFRSEVRTLVDAVLVSLIGVAALTLLIALVEAGVARRRAIAALVAGGTPRAVLARALCWRVLLPAVPGIAIAGLVGLAGMRAFTTTATAGWGRTVCVGTPAECAGPDAERHLEYREVTHTLQAAVPWADIVAVMSIALLAVLLVIGASVLMHRSTTDPAELRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHQ3</accession>
    <name>F4FHQ3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="9" type="ordered locus">VAB18032_26746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735073.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26746"/>
    <dbReference type="EnsemblBacteria" id="AEB46422">
        <property type="protein sequence ID" value="AEB46422"/>
        <property type="gene ID" value="VAB18032_26746"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26746"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_2_2_11"/>
    <dbReference type="OMA" id="NRWYFPA"/>
    <dbReference type="OrthoDB" id="1575081at2"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="22630" checksum="A430EBC3082F9395" modified="2011-06-28" version="1">MSAVPPAESGTAEPGTATRSRRTPVTILLGLAAFAVVVDVLTKHLALVELSDREPVRLLGGAVYLSLTRNSGAAWSLGKDYTWIFPLIAIGVLAWIAWMGRTLRSVPWAISLGLVVGGVTGNLIDRIFRAPGWFVGHVVDMISVFDPYGQVFPIFNIADSALVCGVILAIGLEFTGRQRDGTRLVGDDRKGTGRAAETTAENADDERRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHQ5</accession>
    <name>F4FHQ5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein VAB18032_26756</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735075.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26756"/>
    <dbReference type="EnsemblBacteria" id="AEB46424">
        <property type="protein sequence ID" value="AEB46424"/>
        <property type="gene ID" value="VAB18032_26756"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26756"/>
    <dbReference type="eggNOG" id="COG1872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130694_7_1_11"/>
    <dbReference type="OMA" id="MRLMIRV"/>
    <dbReference type="OrthoDB" id="1997369at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="98" mass="10076" checksum="AE6FE10E8D9A306D" modified="2011-06-28" version="1">MADDTLTVAVRVKPGASRARVGGRYDGPHGPALVIAVNAPAVDGRATEAARRALAEALGVRPATVSLRTGASSRDKLFQITPASPTLTAHLTHLLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHU0</accession>
    <name>F4FHU0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YbaK/prolyl-tRNA synthetase associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26931"/>
    <dbReference type="EnsemblBacteria" id="AEB46459">
        <property type="protein sequence ID" value="AEB46459"/>
        <property type="gene ID" value="VAB18032_26931"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26931"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_0_0_11"/>
    <dbReference type="OMA" id="GPNRVNE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="2">
        <location>
            <begin position="83"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="210" mass="21554" checksum="F3F4707E67A1FEE7" modified="2011-06-28" version="1">MARTGILRSPISPLRPEPGSPGSPDGRQRRLATDSGCTVRPCTGKNGGMQSHPNVRAVQDALDAAQARNGSAAPATVRLLPDAVHTAAAAAEALGVDVGAIANSLVFDADGAPLLVLTSGAHRVDTTGLAARLGITRLRRATPQFVKEHTGQVIGGVAPVGHPQPLRTLVDNALDKYDEVWAAGGVPQAVFPTTYAELLRITGGTPTDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F115</accession>
    <name>F4F115_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07745"/>
    <dbReference type="EnsemblBacteria" id="AEB42669">
        <property type="protein sequence ID" value="AEB42669"/>
        <property type="gene ID" value="VAB18032_07745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07745"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002352_0_0_11"/>
    <dbReference type="OMA" id="HRNSVND"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="744"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122229" checksum="8204A867E03C119E" modified="2011-06-28" version="1">MSRAADGSASRQADAGGAHWAGELEGALKRTGRERLFLIIDQFEELFSHPRQTRSDFARLIGVLAGATRPDGRPLCCLVLVARSDFADEITETGSLADALALGRDDPTTGVHYLLPMTDVELREAIEGPLEQLRVTRYEHGLVDRLMRDVRRLDNPLAPLAFTLTRLWELQQGGRVSLAAYEALGGVAGAMREHFDRVMDEELDSADRETARLLLLRLTAPDGRGGHIRRSVARDELDQRDWTIARRLAGRRIITIMNSPGGGEAVELAHEALLAEWPRLRAWLDEEKDYLGWRNTLSGAMEMWVTSGCRSNKLLDRADLTVSLAAIERWEERLTSSERAFIKRSQLHQRRTRLLLIAGSTVATMVVAALVFVVGSFRGIVDSVDTDVASRASRSMVSWNTNIVQALPSNLAAYRRYPTLEARQALARWDERAALVEKIRPGEVAAPYHNAILSPDKRHVLGRWAPGWREMLWDIERPGPPDITIGEPDEPASGHTFTSDGAQVIYASDDQIVFWEVQRRSAARSVPIRAPRDGAILGIAISADGRTIAYYDGSSAYVADARTGRLLSGPFRARPNAHSKVTPTLSFDKEDRHLSYSSDQDDWTIDWRSGKEVNDANSAMAVDDTKGVDEPYCVDGRDSVKSHIVMGGSQIVELPRECRGYNIKVDRATGDLLLFYNAADPSLRSAPADEVLEIYDLGNGARRGKFRIPDGAVVAVEPSPEGARVILAPGDGYVLLRIPPPDTLARELSVATSAALTPDGRHVATLSVEGTLGLWDVDTGQRLQAVNDPRLRAATPRRASVVISPDGGRVAAIGDGHVRTIGVTAPNTVAAWNISEQDGWKPQETDNESYRRLTASFTDAGNLLIRSGDLISRWDAIAGLRIGEPLTLPIQTYAQGWSARPATTQFAITQHKTNVIELWDIERHALVTSYHLPADGSPHHQPTVVFDDAGRLAAIHRAPRNPIVIDADSGDEVARLPLFGKGIGLSAEPQWESGFSSPLSFAGDRTLILSYRNVLHAWTWPRWYDPFTADEVATWPSVEWPGTGIDRHARTVLLPNPTGGWWIRSTDPEQWRAVLCELFIEGNLIDHEYTKANVTEATRLAGRSLCGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F187</accession>
    <name>F4F187_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732590.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14055"/>
    <dbReference type="EnsemblBacteria" id="AEB43923">
        <property type="protein sequence ID" value="AEB43923"/>
        <property type="gene ID" value="VAB18032_14055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14055"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028028_2_0_11"/>
    <dbReference type="OMA" id="WIAMGDS"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="448" mass="48818" checksum="BCEFA20EAF934294" modified="2011-06-28" version="1">MAASGRAVVIGASLGGLLAARALAESFAEVILLDRDTPPDEPVHRRGVPQGRHVHVLLDRGRQALESLFPELGAELYRLGATPVDLHGQVHWYNDGHRMLPARSDLTAFGMSRPLLEQVVRQRTVALPGVTVVPDCEVTGLLATDDHRRVTGVRLAPRDGRPSTLTADLVVDAGGRASRSPIWLTELGYPTVEQERVEVGVTYVTRRYRREAGQLEDKLGVLSNAMPGCPRYGVVAPQEGGRFAVTMAGILGEEPPVDEAGFVRYATSLAAPQVGELVRHAQPLDEPVLMRFPASVRRRYERLPRFPDGHLVFADALCSLNPVYGQGITVAAVQALLLRRLLARGGRHRLARRFFRRAARVIDAPWSIAVGTDLRFPGVTGHRTRKVRFVNAYLARLHAAAAHDVALGAAFLRVINLIDPPARLLGPGVMLRVLLGARQRPSASSMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1C0</accession>
    <name>F4F1C0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732623.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14220"/>
    <dbReference type="EnsemblBacteria" id="AEB43956">
        <property type="protein sequence ID" value="AEB43956"/>
        <property type="gene ID" value="VAB18032_14220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14220"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_17_11"/>
    <dbReference type="OMA" id="ENDKFTM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="517"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1000" mass="104564" checksum="C4BC4D21981E7D91" modified="2011-06-28" version="1">MPAESSVIDLFEATVARTPDRPAVRFRDQTLTFRKLNQHAEALAESLVERGVGVGDFVPLVIAEGVEFPIGLLAAMKVGAPFVPVDPGWPASRLAELFRQLSPRVVLAVAATAPALVGLGTADHVLIIDRTQLVSGTPTGPRPGPDDLIYGYFTSGSTGTPKCALNRHRGLVNRLAAMSHHFGDGAEQIVLQNSKPTFDSSMWQLLWPLTTGGQVVLPDRQGILDLEQTCHILGRYAVTITDFVPSVLGALVSLLELRADLCAELAGLRRMLIGGEEANGAVLDRLWKLLPDLRVTNTFGPTECSIGSVFHEITEVTGRIPLGTAIGNTAAVVLDDARRPVPPETVGEIYIGGLCVGAGYLGDPERTARAFVPNPFPEIAGDLLYRTGDLGHHTPDGLLMFDGRRDDQVKVGGVRIELAEVERVLAAHPAVRGAAVIVRGEGDARSLAAFVSLRSDESHTVTPATLVDWLRASLPPETVPRAVTVVDEIPLTPHGKLDRRALEQVARTAAGSAPVEAPGSPAEELVASAWCEVLGRAEVSVSVPFADYGGTSLLTHQLAALLGLRQAGPVSLAHLLAADTVRAQARLLGSGQSDTGAAVDLGLLARDADPSDLVGAGVPPAPTVARQLLLTGVTGFVGAHVLAELVTRPEVELHCLVRAADPAAGAARLVAVLRAYGLTDALTALEHALVQGRVRVVTGDLGAPLLGLDDTAFRALAGAVDAVVHAGALVNFLRDYGAHRRPNVFGTGELVRLAAAGSGCRLHVLSTFSVLSAAARGTSGTPIGPDRLPGLDEPLPPGGYDQSKLVAEHLLERARGFGVDAVVYRLGEIWPHRRIGLPNRASLAHSVVYAAARTGVVFPTGARTDHLPVDLLAGCLADAVLGAAPAAGGTVHLLRPGGLGYAEIFARLAEAGAEHLGYAEFRSRLSALAASGDADERLVRVAMLLPAPQGADPVAPASFDRLFTDSSAHFTSCELAGQAFAAGSPLADLAAFLDRLDVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1K7</accession>
    <name>F4F1K7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3 9">2.7.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_20680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3 9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733890.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20680"/>
    <dbReference type="EnsemblBacteria" id="AEB45236">
        <property type="protein sequence ID" value="AEB45236"/>
        <property type="gene ID" value="VAB18032_20680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20680"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044403_3_0_11"/>
    <dbReference type="OMA" id="MGTFWRV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="288" mass="30455" checksum="4C098AE8A7D96ABF" modified="2011-06-28" version="1">MNLAPARQRPTVHQHTSQMFTCQVTLASYGPPVTPFTEVQRRLHALDRRFSRFRPDSELSTLNAAAGHWHPVSDPLHAMLRHALTVATASTGLVNIAVLPQLLAAGYRRSWATGTPRPTPTPVAPTPVAPLADILELRGHTARLAPGHSVDIGALAKGAWADDIVTWLGPNSAASIGGDVACRGPGPDGDGWPVELPHGETLHVRDGGVATSGTAKRRWGTDAHHLIDPRTGRPATSDITQATVHAATGATADWVASAAVIGGHAATDHLTHRADVHHLWLNQTGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1L3</accession>
    <name>F4F1L3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733896.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20710"/>
    <dbReference type="EnsemblBacteria" id="AEB45242">
        <property type="protein sequence ID" value="AEB45242"/>
        <property type="gene ID" value="VAB18032_20710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20710"/>
    <dbReference type="eggNOG" id="ENOG5034186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106645_3_0_11"/>
    <dbReference type="OMA" id="TIHHEAT"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="133" mass="14907" checksum="6210534A2326107E" modified="2011-06-28" version="1">MGTIHHEATLTVPADVAWDFLDRYTRAEVHIFSACVGERQQDDHRVVTLIDGTELWERNVTVDPQRRRAVYAIPGFPGAEHHQAEMRVLTDDNGTATLLWTTDILPHSLAAHLSDTYAVMFSELLAAVNGHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1N4</accession>
    <name>F4F1N4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">VAB18032_20815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733917.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20815"/>
    <dbReference type="EnsemblBacteria" id="AEB45263">
        <property type="protein sequence ID" value="AEB45263"/>
        <property type="gene ID" value="VAB18032_20815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20815"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_11"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="13126" checksum="E42A14A827E72965" modified="2011-06-28" version="1">MIPEDLRYTAEHEWVAAADGGAVRVGITHFAQDALGDIVYVQLPEAGAVVAAGEPLGEIESTKSVSELYAPVGGTVSARNEVLADTPEVINTDPYGSGWLVEIAVADPAAVDGLLTADAYRELTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Q9</accession>
    <name>F4F1Q9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exoribonuclease</fullName>
            <ecNumber evidence="1">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735135.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27056"/>
    <dbReference type="EnsemblBacteria" id="AEB46484">
        <property type="protein sequence ID" value="AEB46484"/>
        <property type="gene ID" value="VAB18032_27056"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27056"/>
    <dbReference type="eggNOG" id="ENOG5032SJD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114979_0_0_11"/>
    <dbReference type="OMA" id="CEFIEDG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004532">
        <property type="term" value="F:exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00977">
        <property type="entry name" value="3_5_Exoribonuc_actinobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030853">
        <property type="entry name" value="3_5_Exoribonuc_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033390">
        <property type="entry name" value="Rv2179c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16473">
        <property type="entry name" value="DUF5051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5051" evidence="2">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="19408" checksum="F8F421A8C93A74FE" modified="2011-06-28" version="1">MVYRYFYDCEFIEDGRTVELVSIGMVDEYGREFYAVSTEFDASRAVPWVRRNVLDKLPSPADRAWRSRERIRDELYDFLVEPLRAGNGEELELWAWYAAYDHVALAQLWGAMPALPREIPRFTKDLRQLWDDRGRPRLPNADSARHDALVDARHNLARWRAMTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1X5</accession>
    <name>F4F1X5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_03190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03190"/>
    <dbReference type="EnsemblBacteria" id="AEB47722">
        <property type="protein sequence ID" value="AEB47722"/>
        <property type="gene ID" value="VAB18032_03190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03190"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OMA" id="LDIIWRM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="470" mass="48094" checksum="5EEBEC851D99438F" modified="2011-06-28" version="1">MSTAAGRGTLAAAVLASGMAFLDTTVVNVALPRLGADLDASVSGLQWTVNGYLLTLAAFVLLGGALGDRFGRRRVFLLGVLWFTGASVLCGLALRTDWLIAARLLQGAGAALLTPGSLSLLQASFHPDERAKAIGVWSGLSGVSTALGPLLGGWLIDALSWRWIFFLNVPLAVLVVLAALRWVPESRDESTSRTRGTGERGRRFDVAGALLGAVALAGVTYALVDAPGRGLQSPPVAGAAVVAVLAAVAFVLVERRRGETAMLPTGLFGSRLFSVLNVFTVLVYAALGGFTFFIAVYLQNVVGWSAFVTGLALVPMTLLLLVGSPVAGALSAKIGPRLLLTVGPALAAVGLLLLREVGPGASYWRQVLPGVAVFGLGLTMVVAPLTASVLAAVADRFAGVASGFNNAASRVGGLLAVAALPLLVGLSGTGYAQPTELTAAYRGALLWCAGLLLAGAAIAAVFVHRPPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2I8</accession>
    <name>F4F2I8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RelA/SpoT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_14740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732727.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14740"/>
    <dbReference type="EnsemblBacteria" id="AEB44060">
        <property type="protein sequence ID" value="AEB44060"/>
        <property type="gene ID" value="VAB18032_14740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14740"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_11"/>
    <dbReference type="OMA" id="DWISSPK"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="141"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="483"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="747"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="823" mass="90467" checksum="50FB315B56842992" modified="2011-06-28" version="1">MSHDVAPPVEGTVHPTGDADGSVNRNSAAAAPGGGPGTALPTGDVARTGAGANITPVEAAADSPPSSSFALSHAPTGRRVRARLARFNAPWQSSQVSEVLEPLISSHRENHPKADARLLQRAFDTAARWHSGQYRKSGDPYITHPLAVATILANLGMDTTTLVAALLHDTIEDTEYTLDQMRTDFGGEVALLVDGVTKLDKVKLGDAAKAETIRKMVVAMAKDPRVLVIKLADRLHNMRTLTFLPRPKQEQKAKETLEILAPLAHRLGMNTIKWELEDLAFGTLFPKRFEEINRLIGEHQPQREALLRQVTQKVQTDLKAAKIKAETTGRPKHLYSIYQKMIVRGRDFNDIYDLVGVRILVDTVRDCYAALGVIHANWQPVPGRFKDYIAMPKFNMYQSLHTTVIGPTGKPVEMQIRTYAMHRTAEFGIAAHWKYKEHKGTQIVGPPAHIDEMTWLRQLLDWQREAADPSEFLDALRFDLSSQEVYVFTPKGDVIPLPTGSTPVDFAYAVHTEVGHKCIGARVNGKLVPLESTLSNGDVIEIFTSKSDTAGPTQDWLGFVKSPRARTKIRQYFNKERREEAIEEGKDAIVKAMRKQGMPLQRMLTSDNLMAIARDLHLADVASLYAAVGDSQVSAQSVVQKLMATYGGEEGAAEDIAETAVATRPPRSRVSSHDPGVVVRGVSDVWIKLARCCTPVPPDSVFGFVTRSGGVSVHRDDCANAEDLRAQGERVVEVSWKLTSASTFLVAIQVEALDRHKLLADVTRVLSEERVNILSATVTTTRDRVAVSRFSFEMADPKHLGHLLAAVRKVDGVFDAYRVTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2T0</accession>
    <name>F4F2T0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735191.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27341"/>
    <dbReference type="EnsemblBacteria" id="AEB46541">
        <property type="protein sequence ID" value="AEB46541"/>
        <property type="gene ID" value="VAB18032_27341"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27341"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OMA" id="PPYSLFW"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="15"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="36584" checksum="5C4D5AB67D8DCA9A" modified="2011-06-28" version="1">MEFRHLGRSGLMVSEISYGNWITHGSQVEEDAAFACVRAALDAGITTFDTADVYAGTRAEDVLGRALEGERREGLEIFTKVYWPTGPGRNDRGLSRKHIMESINGSLRRLRTDYVDLYQAHRYDYHTPLEETMEAFADVVHSGKAHYIGVSEWKASQIREAHALARELRIPLVSNQPQYSMLWRVIESEVVPTSEELGVGQIVWSPMAQGVLSGKYLPGQPPPAGSRATDEKSGANFIAKFLTDDVLTRVQQLRPLADQAGLSMAQLAIAWVLQNPNVSSAIIGASRPEQVHDNVKAAGVKLDAGLLKAIDEIVEPVTERDPARTESPAERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F324</accession>
    <name>F4F324_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736435.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03605"/>
    <dbReference type="EnsemblBacteria" id="AEB47803">
        <property type="protein sequence ID" value="AEB47803"/>
        <property type="gene ID" value="VAB18032_03605"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG5033X7I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089323_0_0_11"/>
    <dbReference type="OMA" id="VAITHDA"/>
    <dbReference type="OrthoDB" id="1863093at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309039" evidence="2">
        <location>
            <begin position="29"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="22496" checksum="ACAD871E29222E39" modified="2011-06-28" version="1">MNHRSKMIGALLAGGTALAATVGGGAPAAAHPFGPPTTAQVVVDGSRVDISWQPAEDDWVVLGQSLGAFEDPSAGPVATQLTGEQKLRESAAVRDYLRERITVSQHGQPCRGELKPLDGLLAQGARLTFDCPAPVRTLDITLTALTDLNQAYRTILRADSASPAETLYTAAADTHQVDFTQSGGGLGSATALAFGVGAAAVLGALLVPLSRRRTRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F340</accession>
    <name>F4F340_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736451.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03685"/>
    <dbReference type="EnsemblBacteria" id="AEB47819">
        <property type="protein sequence ID" value="AEB47819"/>
        <property type="gene ID" value="VAB18032_03685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03685"/>
    <dbReference type="eggNOG" id="COG2248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054164_0_0_11"/>
    <dbReference type="OMA" id="LQGAFWK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021552">
        <property type="entry name" value="ArsP_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11449">
        <property type="entry name" value="ArsP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="415" mass="41856" checksum="EAB3A48FFE5C1712" modified="2011-06-28" version="1">MTEIVLRPIADAFMQVGVYVAVMVALFGWLRWRFGDRVTDGLTRHRRFGPMVGALLGVSPGCGGAIILMPLYARGKVSFGTVIAALVATMGDSSWVVMAWNPMFALKIHTLLFVVGLITGYVVDALGIDPARAVRRTPAVVAVPAGSAAVPTPAGSAPVRPTPVGSGVGGSGSGGSGVGGSGSVPVGSGAGGGLVAVGVPDLAGSRRLLGGVLPQMSASTLFWGLTVPAFAVSVPVLFQLVDPTVLTRALGGIDPYLALGVLGTLLATVIFAAGRGRLADDNLETAHPQSIGATLRHSAHEASFITVWVAVAYLAWQVVTSTTGFDGSQIALGGLLGVLVGAGIGLIPGCAVQIVFTGLYVSGGLPLPTLVANAISQDGDALIPLAALRRHSALMATVITTIPAVVVGSALLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F345</accession>
    <name>F4F345_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Subtilisin-like protein serine protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03710"/>
    <dbReference type="EnsemblBacteria" id="AEB47824">
        <property type="protein sequence ID" value="AEB47824"/>
        <property type="gene ID" value="VAB18032_03710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03710"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536018_0_0_11"/>
    <dbReference type="OMA" id="HEDDDCH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312643" evidence="1">
        <location>
            <begin position="46"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="544" mass="57471" checksum="DFE6E520DD7F9CC8" modified="2011-06-28" version="1">MSDRLSPAGASLGASTRNRRRIVGKVVAAALVPAILLAIGAPAVAASNTLTITTLDRNGKKVNVTTTVVNLATSSSRSVKSNKSTKLPKGSYAVLASIRTGSAVTLGARTVKVSGASKTTVDARKGKKITLGVSPAPAGEGIMAQTRAQICTKSDSASYDVEASDWDGSSLYVIPNSSKKLAFGAMRQWSDSSGLSDSYAVMYTRTGVPSGLSKTYKRSSLGTVNATGRQGTAATVDGLHLAVQPIKRVCGDHMYAGLFGADRPYRTKVHLSPGNWLIRASSYAAAKDGTTVTLGGYMVSRKVVAGESHTLNFFRAAWGPSARLPVVINGRISYSLNSMFADPGFPRDDNVEGGDKATATLTFGGKTVKTKKDKGWEPGDTYLEYKVKKSGWYKLTNNASRYYPEITFPAGMLSPKTSVTYRFKAKPNTSVTAPVYAVTMLPTGLNLYNQAKPGSTTDVKLTLSRPKLNPDAKLGKNPKVKTVTAKASFDGGKTWRSVKVKKIDGTWTAQVGNPTSGAVSLRAKVTDTTGGYTDVTIIRAYAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F374</accession>
    <name>F4F374_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736485.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03855"/>
    <dbReference type="EnsemblBacteria" id="AEB47853">
        <property type="protein sequence ID" value="AEB47853"/>
        <property type="gene ID" value="VAB18032_03855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03855"/>
    <dbReference type="eggNOG" id="COG3959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_4_1_11"/>
    <dbReference type="OMA" id="GDHPDRT"/>
    <dbReference type="OrthoDB" id="1543182at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="25473" checksum="8808952BCC945234" modified="2011-06-28" version="1">MSSLATITTQVAEAAAPLDGRDPVAPLLERVRAGRDFGPNVYSTRDVLWVLYDRVLRVTPATVDEPDRDRFLLSKGHAVAGYYAVLAAKGFIPPDWLDDQGGPDSRLGDHPDRTLVPGVEIGSGSLGHGLGLAVGSALGLRAQGLLDPRVYVLLGDAELDEGSNHEAIAYAGAVGLGNLTAVVVDNSSATYGWPGGVATRFTVNGWTAATVDGHDQDALHAALTGHHGHRPHVVVAVVNNGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F379</accession>
    <name>F4F379_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736490.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03880"/>
    <dbReference type="EnsemblBacteria" id="AEB47858">
        <property type="protein sequence ID" value="AEB47858"/>
        <property type="gene ID" value="VAB18032_03880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03880"/>
    <dbReference type="eggNOG" id="ENOG503401X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1577835_0_0_11"/>
    <dbReference type="OMA" id="ERFVIRT"/>
    <dbReference type="OrthoDB" id="1718368at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="169" mass="19157" checksum="ADC31BBFC4D63CDD" modified="2011-06-28" version="1">MDVFSRTFLPAAAEAGLAVQTATRHMPVFRRCVGASDATVLVTRCSRPDRPMSGEYLLLLTHRRLVITRQTRVLHRLRLHLNTELRELSHVTWSPDPRLHSVELAATAIDGIRERFLVRTQHPKQVWQLDALFNHAFRTRVRATRPRVLATVAEASAVRPTTLHPAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3H1</accession>
    <name>F4F3H1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14835"/>
    <dbReference type="EnsemblBacteria" id="AEB44079">
        <property type="protein sequence ID" value="AEB44079"/>
        <property type="gene ID" value="VAB18032_14835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14835"/>
    <dbReference type="eggNOG" id="COG4768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132014_0_0_11"/>
    <dbReference type="OMA" id="FSYGVRR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="16495" checksum="1BBC25367B44B4FD" modified="2011-06-28" version="1">MGFLEVAALIAAIAFAMLVLILTLPILRLRHTVDATTRMINELNDRTGPLLGDVNTTVRNVNVTLEQVQTSLDGVNLQLAKVDTMTSHAQNISANVANLVTVVSAAAANPLVKVAAFGYGVRKAASARRHAETEREVRDTIKAQRRAARRGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3N0</accession>
    <name>F4F3N0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamine ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_15130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15130"/>
    <dbReference type="EnsemblBacteria" id="AEB44138">
        <property type="protein sequence ID" value="AEB44138"/>
        <property type="gene ID" value="VAB18032_15130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15130"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_1_11"/>
    <dbReference type="OMA" id="EMFAQGK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="49"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="26998" checksum="262915C8B3767DC8" modified="2011-06-28" version="1">MLIAAASTAAVGTLLAFAVTGAPGWDRVRASFFDPQIARDALPAVLTGLWLNLRLLVCCAIGALLLGLVIAILRTLRGPVFFPIRALATSYTYAFRGLPLIIVLYLLTLGVPGLRLQGMPPVLVLGGLALVLTYSGYLAEVFRAGIESVHPSQLAAARSLGLTYRQTMRHVVLPQAVRRVAPPLLNDVVALQKDVGLVSLAGPIDAVRAAQIATAQSFNYTPYIVAGVLFVLLAIPLIAVTDRVTLRAARRQSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Z4</accession>
    <name>F4F3Z4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pfkb domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_27836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27836"/>
    <dbReference type="EnsemblBacteria" id="AEB46640">
        <property type="protein sequence ID" value="AEB46640"/>
        <property type="gene ID" value="VAB18032_27836"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27836"/>
    <dbReference type="eggNOG" id="COG1105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050013_3_0_11"/>
    <dbReference type="OMA" id="VTIEQHH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="34143" checksum="844BDAD6FC026BCE" modified="2011-06-28" version="1">MTGHVMVFAPTPLLTVTVDQPSDVPELHLHPGGQGVWQARMVLSLGVDVVLCTALGGEIGEVLAPLLVGEGVDLKVVNRDSGGSGGYVHDRRGGTRREIVDVPGQPLSRHELDELYNLALSEGLRAEVCVLSGPNDPSLVPADLYRRFAADLGANGSRVVVDLSGEHLTAVVDSGVFFLKVSHEELIADGRAADDDEEQLTRAMYDLHAAGAENVVVSRAEKPALALVDGEVFEVLMPQLEAADPRGAGDSMTAGVAAVVAQGGDVRTAIRTGAAAGALNVTRHGLGTGRVDSITGLVERVQLEPASIRPQHRTTPDELAHRAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4M5</accession>
    <name>F4F4M5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732832.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15275"/>
    <dbReference type="EnsemblBacteria" id="AEB44167">
        <property type="protein sequence ID" value="AEB44167"/>
        <property type="gene ID" value="VAB18032_15275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15275"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_8_5_11"/>
    <dbReference type="OMA" id="MNRIGRE"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023934">
        <property type="entry name" value="LLM_FMN-dep_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04036">
        <property type="entry name" value="LLM_CE1758_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="371" mass="41357" checksum="ADF6BDCE7F11D670" modified="2011-06-28" version="1">MQFGVFTVGDVTVDPTNGREPTERERIKAMVTIALKAEEVGLDVFATGEHHNPPFVPSSPTTMLGYIAARTERLLLSTATTLITTNDPVKIAEDYAMLQHLADGRVDLMMGRGNTGPVYPWFGQDIRNGIPLAIENYDLLRRLWREDVVDWRGKFRTPLQSFTSTPRPLDGVPPFVWHGSIRSPEIAEQAAYYGDGFFANHIFWPAEHTKRMVGLYRQRFAHYGHGSADQAIVGLGGQVFMRRNSQDAVREFRPYFDNAPVYGHGPSLEEFTAQTPLTVGSPQQVIDRTLGFRDYVGDYQRQLFLMDHAGLPLKTVLEQLDLLGEEVVPVLRKEFESLRPAHVPLAPTHASLRAAAEQAATDQSAGAEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4N4</accession>
    <name>F4F4N4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732841.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15320"/>
    <dbReference type="EnsemblBacteria" id="AEB44176">
        <property type="protein sequence ID" value="AEB44176"/>
        <property type="gene ID" value="VAB18032_15320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15320"/>
    <dbReference type="eggNOG" id="ENOG503460B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155175_0_0_11"/>
    <dbReference type="OMA" id="PRLAYIE"/>
    <dbReference type="OrthoDB" id="2050885at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="13886" checksum="3B07C000F5208D54" modified="2011-06-28" version="1">MRIQISHDLLDRQLVDVDGRLIGKVDDVEFALDAHGTPYLRTLLTGPGALGLRVGGRIGRMLALTAERFVSDRPMVPLRIPYGFVARIDSAVWLRIRAEDLPTSPVELWLRRHLIGKIPGAGRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Q3</accession>
    <name>F4F4Q3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">VAB18032_15415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15415"/>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="EnsemblBacteria" id="AEB44195">
        <property type="protein sequence ID" value="AEB44195"/>
        <property type="gene ID" value="VAB18032_15415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15415"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_11"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="272"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB44195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="537" mass="58331" checksum="88CFCD9C966E14F1" modified="2011-06-28" version="1">MVMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDRALSGKANVTTGQIYSDVIAKERRGEYLGDTVQVIPHITNEIKSRILAMGDPDDDGRTPDVVITEVGGTVGDIESLPFLEAIRQVRHDLGRDNCFYLHVSLVPYLAPSGELKTKPTQHSVAQLRNIGIQPDAIVCRSDRDIPDKLKHKLSLYCDVDAEAVIAAPDAPSIYDIPKVLHREGLDAYVVRRLGLSFRDVDWDGWDDLLERVHQPQRTITVALVGKYVDLPDAYLSVSEAIRAAGFGNRARVQLRWVPSDDCVTPTGAAAALAGVDGIVIPGGFGVRGIEGKIGTARYARENGIPLLGLCLGLQCMTIEVARHLAGLEGANSVEFDAEAVHPVIATMADQEDIVAGKGDLGGTMRLGAYPAKLAEGSIVAEAYGSTEISERHRHRYEVNNAYRDQLTKAGLHISGTSPDGRLVEFVELDRELHPFFVATQAHPELKSRPTRPHPLFAAFVQAAVAYSQADQLPVDLDAAERVTRNGTAAPATSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4R5</accession>
    <name>F4F4R5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15475"/>
    <dbReference type="EnsemblBacteria" id="AEB44207">
        <property type="protein sequence ID" value="AEB44207"/>
        <property type="gene ID" value="VAB18032_15475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15475"/>
    <dbReference type="eggNOG" id="ENOG5033CF6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2494450_0_0_11"/>
    <dbReference type="OMA" id="GPPFIQI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="77" mass="8749" checksum="1613D3B7C9C7E232" modified="2011-06-28" version="1">MPAPEGGDIIRLSPKPFMSTEELAELLDVDPSTIRRWRTLQPLQGPPFIQISDRVVKYATADVERWLSARRVYPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4W5</accession>
    <name>F4F4W5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21770"/>
    <dbReference type="EnsemblBacteria" id="AEB45454">
        <property type="protein sequence ID" value="AEB45454"/>
        <property type="gene ID" value="VAB18032_21770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21770"/>
    <dbReference type="eggNOG" id="ENOG5030SBS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520619_0_0_11"/>
    <dbReference type="OMA" id="WTYERAD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="520" mass="57543" checksum="994D907E5EC13CEC" modified="2011-06-28" version="1">MSGDFEIHITVHAGKAEELRTFAGERGVKFVHIVLDRGAYASQPMLTLSGRGTLTEQRDTVQRWERELRGVGIYPCRSKIEAAPWCVGVPQSDEQVVAEPGGRYFEHHVKLLLPTTAVADLVALTDLVAPHGARLSRNARREFADGAQERFVNQRCHGVGLATARHRLDKLVETLRAAGHEPTTVEQEYVVFDSALHHDHGWLDSPEPAASGYQRKRENRMRSAPADSPDYPPTYRPLPAGPTVRQRAAFDPALKQYPNAYRAGEPDFLVPATGQRWTDARRTAMNHILAAAAATTWHQHLVLRGSVTMAAWVGDAAREPGDLDFVVTPHTITSDSTDARTLLDDIKTAVRTATGGGLQPDRITESAIWTYERADGRRLLVPFRTPEAPDGHVQIDIVFGERLPLPPEVVILPGVDEPLLAAPASLALAWKLLWLATDMYPQGKDLYDAVLLAEHTSVDQALVRELMRPELGVEADTFTAETVLSWQVDWSNFTDEYPGISGTAEQWTKRLALALDQAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5D9</accession>
    <name>F4F5D9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731642.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09265"/>
    <dbReference type="EnsemblBacteria" id="AEB42971">
        <property type="protein sequence ID" value="AEB42971"/>
        <property type="gene ID" value="VAB18032_09265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09265"/>
    <dbReference type="eggNOG" id="COG4760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074030_0_0_11"/>
    <dbReference type="OMA" id="VWIYLEM"/>
    <dbReference type="OrthoDB" id="1395601at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="292" mass="30951" checksum="C0FE1E5C836903C7" modified="2011-06-28" version="1">MKTSNPVLARLGQAAERERAAGYAPTGPYGQPGYPQQYPQAGYPQQPGYPQQYPPQAGYPGAPGFPAAPQAVTPMSIDDVVVKTVMLLAIVGVSAAAAWILVPDALLGVAWIGAAIVGLVLGLVISFSKMANPALVVAYAVVEGVLVGAISKFFEARYPGIVIQAVVATFGVFFVMTMLYKARVIRATPKFTKGLIAVMAGLFAVMLINLVLSLFGVNTGLRDGGALAIGFSLVCIVVASLSFVLSFKEVEDGVRMGLPQRYSWVAAFGILVSLIWLYIEILRLLSYFQGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5G3</accession>
    <name>F4F5G3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ordered locus">VAB18032_09385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09385"/>
    <dbReference type="EnsemblBacteria" id="AEB42995">
        <property type="protein sequence ID" value="AEB42995"/>
        <property type="gene ID" value="VAB18032_09385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09385"/>
    <dbReference type="eggNOG" id="COG0026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_0_2_11"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="100"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="385" mass="41007" checksum="BA8412478EA58D2B" modified="2011-06-28" version="1">MVGGGQLARMTHQAAIALGQSLRVLALTPDDGAALVAADVQYGDHTDLAALRTFAKACDVVTFDHEHVPTEHIRALAGEGVKLYPPADALVHAQDKRVMRERLDAMAAPNPAWRPVESTADLVAFGDEVGWPVMVKAARGGYDGRGVWPVGDAAQATELAETLLAGGTKLIVEERVALRRELAVQVARSPFGQVAVYPVVETVQRDGICVEVLAPAPDLPEELAVAAQQLGIDLATALGVVGLLAVELFEVADPSTPSGSRLLVNELAMRPHNSGHWTIEGARTSQFEQHLRAVLDYPMGDTSLAAPVVVMANVLGGEPGGMPIDERLHHLFAAEPTARVHLYGKQVRPGRKIGHVTVLGDNLDEVRARAARAMRWLRDGTEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5K9</accession>
    <name>F4F5K9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_09615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731712.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09615"/>
    <dbReference type="EnsemblBacteria" id="AEB43041">
        <property type="protein sequence ID" value="AEB43041"/>
        <property type="gene ID" value="VAB18032_09615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09615"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="OMA" id="GMKYVTM"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="478" mass="51326" checksum="E4FFDFEBD34CFDF6" modified="2011-06-28" version="1">MSDQQKLRNFVNGEYVEPVDGGYADLIDPCTGEVFAQAPVSGAADVDAAMRAAATAFESWRDSTPAERQKALLKLADAVEARAADLVDAEVRNTGKPRQLTADEELPPAVDEFRFFAGAARLLEGRSAGEYMAGHTSYVRREPIGVCAQVTPWNYPLMMAVWKIAPALAAGNTVVLKPSDTTPVSTLLLAEIAAEVLPPGVFNVVCGDRDTGRALVAHPTPQLVSITGSTRAGMEVAAAAAPDLKRTHLELGGKAPVVIFDDADIAAAAEAIAMGGYFNAGQDCTAATRVLTAPGVHEDFVAALTEQARNTRTGAPDDADVLYGPLNNANQLARVRGFVDRLPDHANLQTGGAQVGERGYFYAPTVVSGLQQADEIIQQEVFGPVITVQRFSDEDEAVRWANGVDYGLSASVWTRDHGRAMRMTRRLDFGCVWVNTHIPFISEMPHGGFKHSGHGKDLSIYSLEDYTRIKHVMHNIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5M8</accession>
    <name>F4F5M8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_15645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15645"/>
    <dbReference type="EnsemblBacteria" id="AEB44241">
        <property type="protein sequence ID" value="AEB44241"/>
        <property type="gene ID" value="VAB18032_15645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15645"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070583_0_0_11"/>
    <dbReference type="OMA" id="EGFICRI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309104" evidence="3">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="29754" checksum="D6C25A455CFB2216" modified="2011-06-28" version="1">MVLAVTAASTAVGAAPAQAAGRAGHCPDADGVTVVVDFKELGGGVVIRCAPGDQATGLAALKNAGFQITGTLRWGEGFICRIEGKPSAATEKCVDTPPASAYWSYWHAPDGGAWTYSDKGVLNRKPPAGSFEGWSFSLNRSADNAPRPAVAPNRPAPPRTTPPAPPPPRTSAPAPPPPAPTPPAPGNPPPALPPPTADAPVAPGVGTPTGAGGTPAASVPVAPTGDPSGPAPQVPPTASVVPPLGAAPVPSTDPTGSLPPVEVTGARDGDGLPLGTLAGLFLLVALVGGGVLAARRRRTPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5R5</accession>
    <name>F4F5R5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop containing NTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732942.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15840"/>
    <dbReference type="EnsemblBacteria" id="AEB44278">
        <property type="protein sequence ID" value="AEB44278"/>
        <property type="gene ID" value="VAB18032_15840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15840"/>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310989_0_0_11"/>
    <dbReference type="OMA" id="QVYERCA"/>
    <dbReference type="OrthoDB" id="1485731at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="238"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="945" mass="104352" checksum="88346DB3FC36D23E" modified="2011-06-28" version="1">MDMATLGQLATKAAVNCSTVIGRKLLTRHQRNKIATDAAGILVAGNTERFIEHLNPRQLRGFREFTESAQFDHLVRQAMISSLASTTDDTRSAIREQLRHGLRHHGEFGEADLLQATDVLHELVDAAVHAVRQTAAPGTLDSGRAVAMAARVAAAGVLNSELLNRLKTLDEVHQFAKAVRSATKAGHAKLRMAAHDLNRQVDYAQLYVTPVLRPAASSVWDSSASETFTLADGMNNEVRFVILGDPGAGKSTLAAKLAHDLAADRIGGLEGQVPILLVVRAHTQSLRTDHHTLLHYLEAACRRPGNVNPPPDALEYLLLNGRATVIIDGIDELGDSSYRQSFAGLVDGFAHRYPLARVIVTSRAVGYPDAPLDSDLFPTVDIAPFNETQVNQYANRWFRLDTTLDADQRRQLTEAFMRESEVARDLRVNPLVLSLLCGLYSTVHYIPRNKPEIYEKCAELLFETWDRSRGIEVTHRYGAHIRPAVQRLAWRLFTDPQGRQALPRTELIAFLAEYMKTKRFEDPDEAAQAAADFLDFCAGRAWVLTDVGSDALQPHYGFVHRTFLEFFAASQLVKHQPDPEVVWGQLEPHLADSTWDVVGQLAVQILDRHCDDGADRILRLVLARVDEVPSASLSHLSFAARCMENVAPDNATLRDVVTRVVALSCAAPAADRRRTQLELFPEVDIPLSALLAVTAPDNATRIARAMADAVEHHARVSPLSSSAGLLYDTLLNKPIALNDGTGELIKGLVADDLSQRAVPETARVWHRLVQRPTADDLAEYGLSILYELTYVAGAGILPVLAWILTGTVSPPVGRAAAVFGRWDRTLAGYYPQIITNHDWLLRAVLPRNVWEPVLTRFEEAALREMSKHGRAALILLLLPIMRVARNRRDVDQLEQLMTAVEGGYHEAAIEIVNSWALPAEAHDFLVEWVRRPQLTGATPPGSVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5V4</accession>
    <name>F4F5V4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734166.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45513">
        <property type="protein sequence ID" value="AEB45513"/>
        <property type="gene ID" value="VAB18032_22065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22065"/>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863168_0_0_11"/>
    <dbReference type="OMA" id="FDERARW"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="322" mass="33986" checksum="6BDA2EEB092DAA55" modified="2011-06-28" version="1">MAIAVASVVMLSGCGTDAEIAPERLATAQDGHIVSVAWLPSGQLYVLRYVDSASLTRLAMITSSGRGETVVVSSTGFCGAPEIVTISILPDGRLGAVVDCEATTTHVSSRIAAALDDGKLVKLATLGAQWLVSWDDDLSNGWVEYAAGDCRSIARYVRGHVVPFPKYGPAQLVPFGLDQDFFDPSGCSTPGRAGFLAVARSGEVFFLVSDEAESLFDERARWRAMTFDPASGLIRQTGPELTDPSDVAVSPDGAALLVSGRHDNRSGVWRIDTTSGEFSRVLPGRFGAIGVSADSRRAAIARRTETGDDLVPLDLVQTTPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F614</accession>
    <name>F4F614_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734226.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22365"/>
    <dbReference type="EnsemblBacteria" id="AEB45573">
        <property type="protein sequence ID" value="AEB45573"/>
        <property type="gene ID" value="VAB18032_22365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22365"/>
    <dbReference type="HOGENOM" id="CLU_1685824_0_0_11"/>
    <dbReference type="OrthoDB" id="2135875at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312717" evidence="1">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="16457" checksum="F7607FC97E4DF87D" modified="2011-06-28" version="1">MRLRVLAATVVVLPLLAACGDGSAAPSGGGRDLLANLPSCDRVPIDDDPEVDADVPGLALPEGSRVTAVVQQGVLTTVEATLRMSPLDVRAHYEQRTDIDVLRVEDEIFETEVLARTEARRMYLRASALCADGSSLTVVVGPDSEDAGLPEFRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F660</accession>
    <name>F4F660_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">VAB18032_28706</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28706"/>
    <dbReference type="MEROPS" id="M01.009"/>
    <dbReference type="EnsemblBacteria" id="AEB46812">
        <property type="protein sequence ID" value="AEB46812"/>
        <property type="gene ID" value="VAB18032_28706"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28706"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007335_1_1_11"/>
    <dbReference type="OMA" id="CAYTNTG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="122"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="249"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="544"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB46812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="865" mass="95768" checksum="13B2B911521B9ED5" modified="2011-06-28" version="1">MAVAYGENGMETNVPGVRNLTQVEATERARLLDVTGYDINLDLSSAVHAAGGRTFRSITEVHFRCTEPGASTFIEVAADSVRSATLNGTSIDLAGFSAEKGLTLTGLAGENVLVVDADFAYSNSGQGLHRSVDPVDGETYLYSQFETADAQRVFACFDQPDLKSVYTWHATVPEHWKVISNAPVERVEPAGDDLKTVHFATSARMSTYITALCAGPYHEVRDSHDGIDLGLFCRTSMAQYLDSDDLFLITKQGFDFFHEQFGVRYPLPKYDQLWVPDFNAGAMENFGCVTHAESHYLFRSQVTDFEYEQRANTILHEMAHMWFGDLVTMRWWNDLWLNESFAEWASHWCNTHATRFTEAWTTFLSIRKNWGYRQDQLSSTHPVYCEMPDLEAVEVNFDGITYAKGASVLKQLVAYVGLESFLAGLRAYFAKYAWGNATFDDLLSELEAASGRKLRTFASQWLETAQVNTLRPELTIGPDGTYQQVVVRQEASEGYPTLRTHRIGVGLYDLTEGRLVRRERLEVDIDGELTELPQLVGVPAADVLLLNDDDLTYTKLRLDERSMATVVQHIAGFDSSLARALCWTAAWDMTRDAELATRDYIALVLAGLPAETDINLVTATLRQASSALTFYADPAWAPTGWADLARTARTALASAEPGSGFQLAWARAYVSAARDPEDLAVLRGWLDGTQVTQGLTIDTELRWSVLQALVANGVAGAPEIDAELARDRTSSGEREAAYAHALVPTAENKAAVWAQLTGAEALPNWRNRALLQGFSHPAQVELITPYRPRYFEVVGQVWASRDSEPAQEFAMLAYPAYLVEEDTVEATDAWLAQQGSPAPLRRLVAEGRDGVVRAVAARARDARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6B5</accession>
    <name>F4F6B5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_09715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09715"/>
    <dbReference type="EnsemblBacteria" id="AEB43061">
        <property type="protein sequence ID" value="AEB43061"/>
        <property type="gene ID" value="VAB18032_09715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09715"/>
    <dbReference type="eggNOG" id="ENOG5032SSX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376800_0_0_11"/>
    <dbReference type="OMA" id="TIFARVW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="113"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="223" mass="24161" checksum="14A55E7AB1F4257A" modified="2011-06-28" version="1">MSFTRWWTETTAALGDHVPLPLVALLLVLTTMLASTGWYTYPAWVPRRFPRPHRFPRLRRRRRPARAPRPRRADTDPAVDLASPQPTGPPAHHVTLADRLAAEGRYDEAIRERLRGMVRELSARDLVSVRPGTTVTEIVEAAATRHPPAGPPLAAAATIFARVWYAQHPGTADHDQRVRDHAATLHRLLTDGPADSSDGAVSAGSGGVSAGSGGGEGSGEYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6G6</accession>
    <name>F4F6G6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731783.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09970"/>
    <dbReference type="EnsemblBacteria" id="AEB43112">
        <property type="protein sequence ID" value="AEB43112"/>
        <property type="gene ID" value="VAB18032_09970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09970"/>
    <dbReference type="eggNOG" id="COG4334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2083871_0_0_11"/>
    <dbReference type="OrthoDB" id="2012397at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016888">
        <property type="entry name" value="UCP028498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10012">
        <property type="entry name" value="DUF2255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="12947" checksum="F8F8E4753E8EF8B3" modified="2011-06-28" version="1">MTNAIGEALSGVQEVELTVTGRKSGRQIARPVWFVQDDDNVFLMPLTGSDTQWYKNVQQTPMVQLAVDGTSLSSSATPITDTRQVENIVAMFRDKYGPEQVESYYPKHDVAVQVPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6R7</accession>
    <name>F4F6R7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734244.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22460"/>
    <dbReference type="EnsemblBacteria" id="AEB45592">
        <property type="protein sequence ID" value="AEB45592"/>
        <property type="gene ID" value="VAB18032_22460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22460"/>
    <dbReference type="eggNOG" id="ENOG5032T8C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110230_0_0_11"/>
    <dbReference type="OMA" id="CTGNSAP"/>
    <dbReference type="OrthoDB" id="1908794at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313627" evidence="2">
        <location>
            <begin position="28"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="26877" checksum="211DC6BA3E7C875F" modified="2011-06-28" version="1">MKRLTPLLTLLSGAVTAAVLFTMSAQASPPRTQPTGENAPPAVAAPPQDEADVDDEAPVDDEQPDPEDSRQPGVSPPDEPEESPDGVDVSSVEQNWIGQLENGATIAITVSGGKAEAYVCDGRSMEVWLSGTVRDGKIELTGKDAKLTGIIRGDSASGEMIVGVRRWKFTARPDSETVDEAETKSGAGTDPAIYRATDEVRKAGIDGGWIMLPDGTQIGIVTWNGKPIPAPPLDPAFNSTVVNGVTIVAEPVIPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7D4</accession>
    <name>F4F7D4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mov34/MPN/PAD-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_10370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731863.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10370"/>
    <dbReference type="MEROPS" id="M67.009"/>
    <dbReference type="EnsemblBacteria" id="AEB43192">
        <property type="protein sequence ID" value="AEB43192"/>
        <property type="gene ID" value="VAB18032_10370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10370"/>
    <dbReference type="eggNOG" id="COG1310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_1_0_11"/>
    <dbReference type="OMA" id="GAHYVLV"/>
    <dbReference type="OrthoDB" id="1811367at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="162" mass="18099" checksum="0D8A99BC58E82603" modified="2011-06-28" version="1">MLTIDRSIVDAIVAHARRDHPDEACGVVAGPVGSDKPTRHIPMENAARSMTFYEFDSMEQLRVWREMDDRDEEPVVIYHSHTATEAYPSRTDIAFAGEPGAHYLLVSTREPDTEEIRSFRIVDGMVTEEPVRILDAGVDPHAVQSYMFGQSPATVDYECSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7D7</accession>
    <name>F4F7D7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731866.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10385"/>
    <dbReference type="EnsemblBacteria" id="AEB43195">
        <property type="protein sequence ID" value="AEB43195"/>
        <property type="gene ID" value="VAB18032_10385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10385"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_3_0_11"/>
    <dbReference type="OMA" id="HIPPWTD"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="26397" checksum="05427B9F13885CC0" modified="2011-06-28" version="1">MRLTVLGCAGSFPGPESPCSAYLIEAEDFRLLIDFGPGSLSTLQRYAGLHAPDAILLTHLHCDHILDATSYVVVRRYAPDGPYPPLPVYAPAGAPERLATAYGQEGASVEDVYQFYALEPGTFPIGPFTVTVDRVLHPIETYGVRLEHDGRVLCYSGDTAPCEALIRLAQNADTFLCEASYLDGVDNPPDLHLTGREAGEAAAKAGVGRLLLTHLVAAWGSEAHTVASAAAAYTGPLEVVRPGSTYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7H0</accession>
    <name>F4F7H0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_16525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16525"/>
    <dbReference type="EnsemblBacteria" id="AEB44409">
        <property type="protein sequence ID" value="AEB44409"/>
        <property type="gene ID" value="VAB18032_16525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16525"/>
    <dbReference type="eggNOG" id="COG3339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130372_0_0_11"/>
    <dbReference type="OMA" id="LDAWPGE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="6">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="133" mass="14646" checksum="2F9D19C4CBE9F7E1" modified="2011-06-28" version="1">MIMRDWLVGLAIAVVLLLASWALLILLARRLPPGIMRDLAAFIPDCVTTVRRLRTDPRVPRRAKIAVLIAGIWVASPIDLIPEFLPVIGPLDDIVVVALALRYAARQVPRDVILAAWPGEPRLIERLLGTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7I3</accession>
    <name>F4F7I3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733082.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16590"/>
    <dbReference type="EnsemblBacteria" id="AEB44422">
        <property type="protein sequence ID" value="AEB44422"/>
        <property type="gene ID" value="VAB18032_16590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16590"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_4_11"/>
    <dbReference type="OMA" id="ECVADKH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="25494" checksum="5C75D627BD922035" modified="2011-06-28" version="1">MSSLDYTYENIDKVIDRSTWVAPTIDPGKTMLLVLDMQKACAEPGGAMYIPSIGGAPEGKDVVQPVVNVLDTCRAKGIPVVWSLWGLRGDGKDAGYADRKWGLEGQLATFPGSWGNGGDELVNELKPLDDEPVMRKHRFSSFYGTPLTEYLRRAGCDTLVVAGLSTGNCQIATAIDGNNQDFKVVVLADTTAAIPASIPGAAEQPLGFGQHWEALRNIQANHGDVRTSVEFLRMIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7L2</accession>
    <name>F4F7L2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16735"/>
    <dbReference type="EnsemblBacteria" id="AEB44451">
        <property type="protein sequence ID" value="AEB44451"/>
        <property type="gene ID" value="VAB18032_16735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16735"/>
    <dbReference type="eggNOG" id="ENOG502ZZ9Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135070_0_0_11"/>
    <dbReference type="OMA" id="MPDEWAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="11088" checksum="76FC35A41E5410F7" modified="2011-06-28" version="1">MTALLSQALTSDVVFWGPLGRSEGIAAVERFVLDIRRHPAGTGTMVRCSAVDMPDEWARYQWVFTTPNGGPRLAGTDVVHLRRSLIDQFIIFAGEIEPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7S5</accession>
    <name>F4F7S5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734364.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23060"/>
    <dbReference type="EnsemblBacteria" id="AEB45712">
        <property type="protein sequence ID" value="AEB45712"/>
        <property type="gene ID" value="VAB18032_23060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23060"/>
    <dbReference type="eggNOG" id="ENOG502ZKCI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490859_0_0_11"/>
    <dbReference type="OMA" id="GQELEDC"/>
    <dbReference type="OrthoDB" id="1927056at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="86" mass="8682" checksum="F6C45F08E460D565" modified="2011-06-28" version="1">MASVAELKAAIDIALQQIGDGQSAVQAAGEKLAEAQQTLAGALEGSGHTTVEAAQASLTQASQELEECLAATLVAVEQAQQYVATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7T8</accession>
    <name>F4F7T8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_23125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734377.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23125"/>
    <dbReference type="EnsemblBacteria" id="AEB45725">
        <property type="protein sequence ID" value="AEB45725"/>
        <property type="gene ID" value="VAB18032_23125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23125"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_101_2_11"/>
    <dbReference type="OMA" id="GEGHAAF"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="70"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="70"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="19431" checksum="B600F436C5DA103F" modified="2011-06-28" version="1">MSVVAISPRQHPSGRTSRSRLVRRRANPTLTITVDLAAAAASPRLNRLLELLGELAASGEGRLSRDDADHPPIAADPSVIRILTGPRSVQQGDRVVPLTRIEYDLLLFMAERPRRVFTRIQLLNQVWGYDHAVARTVDVHVRRLRAKLGVDTPLLTTVHGVGYRLADEARVSVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7U4</accession>
    <name>F4F7U4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Antar domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_23155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734383.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23155"/>
    <dbReference type="EnsemblBacteria" id="AEB45731">
        <property type="protein sequence ID" value="AEB45731"/>
        <property type="gene ID" value="VAB18032_23155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23155"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074354_0_0_11"/>
    <dbReference type="OMA" id="MTQRGCR"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="246" mass="25994" checksum="FF8157C928F56726" modified="2011-06-28" version="1">MNLETSPPLAETLGVLETAALLRELTAGLIALDDFDEALSALVRITRDAIAGVNWCGFTALRAGEPAGVAASDAPMSGLDDLRYGADTPAMDAIRLREMVRAENLATERRWPDWTARAGELGVLGVISAPVDVDEQVIGAINLYAGRPDALTTGHQLTAMLLAEHAGLLLAAVRDRQRRSAQADAQDVALLGDGVIGQAIGVIMTQRGCPPEDALEVLRSAASSLSIPLRQVAERLVSTVSRPRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Z2</accession>
    <name>F4F7Z2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fha domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735615.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29481"/>
    <dbReference type="EnsemblBacteria" id="AEB46967">
        <property type="protein sequence ID" value="AEB46967"/>
        <property type="gene ID" value="VAB18032_29481"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29481"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1874565_0_0_11"/>
    <dbReference type="OMA" id="WVDGAIV"/>
    <dbReference type="OrthoDB" id="1850218at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="14771" checksum="32CB70804DB191AE" modified="2011-06-28" version="1">MEQHPQLLPMLTVAAGPMRGLSFRLRAQPMVIGRDTAADIVVHDPHMSRRHAEIRLAGDGVSLLDLGSTNGTWVNGLRTTGPVCLTDGDMILIGRTELRFFDPALARTDPVGLSFGVPRQERRTTLVLPTGGVRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F816</accession>
    <name>F4F816_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="16" type="ordered locus">VAB18032_29601</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
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        <property type="protein sequence ID" value="AEB46991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
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        <property type="protein sequence ID" value="AEB46991"/>
        <property type="gene ID" value="VAB18032_29601"/>
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    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_079215_5_1_11"/>
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    <dbReference type="OrthoDB" id="1999641at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
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        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
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        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
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        <property type="entry name" value="ATP-synt_B"/>
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        <property type="entry name" value="ATP_synt_b"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB46991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="19396" checksum="D501B3125FCED3BA" modified="2011-06-28" version="1">MNLAAEGVEHHPLVPIWQELVVGSIAFALLCFVLMKFVLPRMETMYQARVDAIEGGLKRAEAAQAEANQLLEQYRAQLAEVRTEAAQIRDDARADAESIRTEILAKAREESDRIIAAGRESLAVERQTIVRELRAEVGGLAVDLASRIVGESLADEARRKGTVERFLTDLESAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F849</accession>
    <name>F4F849_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43210.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
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        <property type="entry name" value="SSF53448"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="34832" checksum="798C7FACAE940601" modified="2011-06-28" version="1">MPDVSVVIPTTGRPSLAEAVATARAQQGVSVHLVVVCDLAEVPTGVTDLRDQIDEIVCTGGGRRGSYARNLGVRHAAPGSHIAFLDDDDAWLPHKLVAQLPVLERLAGEGWLPVVSSRTLQRKAGSSPLPTAVPTTLIADGALPEDYLFRRRHLGVGRQSLPTSTLLTTADLARQCPWDETLPRHQDWDWLVRAARIPRAKIVQIEEATAIYTVGSPGSISASADWRTSWDWAQRWEGVWAPETFSDFIAAQTLRYAVQARDREGVREMVRAIRRNRPPSARNAVLAALGLVPRSALERVAMRGSRTTGGGDPLQADGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F885</accession>
    <name>F4F885_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10640"/>
    <dbReference type="EnsemblBacteria" id="AEB43246">
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        <property type="gene ID" value="VAB18032_10640"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="FGDVWQR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="128" mass="14496" checksum="1BD2F06D1136F8E2" modified="2011-06-28" version="1">MNQPLARHERGEAMFKHVFGREPRPGSYPDFLQLTIDHLFGEIWTRPHLSVEERELIALTAVTLARTDWELRGHIGAALHLGMSQEKIVEIIIQLAYYGGWPVANNGLRIAQEVFAELATGKDADHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F893</accession>
    <name>F4F893_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731925.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10680"/>
    <dbReference type="EnsemblBacteria" id="AEB43254">
        <property type="protein sequence ID" value="AEB43254"/>
        <property type="gene ID" value="VAB18032_10680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10680"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033540_1_0_11"/>
    <dbReference type="OMA" id="IMTHALM"/>
    <dbReference type="OrthoDB" id="1759737at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="445" mass="47008" checksum="292BECE002964FE7" modified="2011-06-28" version="1">MATVTTWTGQDANALRNALRMSVTAFAEHVGAARRTVAKWSSRGDKVLPRADMQAALDTVLSRATPEVRERFEALRAKGTSGAAADAAGPPADIQADTGADGDGDSGSDGDVRRRDLLRGAAIGIAATPNVAPLLDALFTPTTSDSAALSIPHLTRAVAAVKVDYQACRYERVLDRLVTLLPSLEPVRSSTEGERRQRVETLAADLYHVVGSVLLKVGDRGMALIAAERSARAAALSEDPVAIAASARIMTHALMGNSHDAQAVTLAGNAAQSLDRDTRLASSDAVAVYGALVLRGAIAAARRDDRDTAHTMLDEATRAASRLGYDGNDRWTGFGATNVQLHRVNIALTLGNAGTAIAIARTVALEKVTLAERKASLFVDVARAYTQWGRYEHGLNALRTAYEVAPEEIRCRPTVQRIASDLAMRANGSARISAVAFAQSAGIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8E9</accession>
    <name>F4F8E9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44494">
        <property type="protein sequence ID" value="AEB44494"/>
        <property type="gene ID" value="VAB18032_16950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16950"/>
    <dbReference type="HOGENOM" id="CLU_3085996_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="52" mass="5536" checksum="30D3907F6CE8E82F" modified="2011-06-28" version="1">MVAAVLAATTAALLLEFRHEAELGAWWASRCQPATVVLLVRTTRSKPASTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8J2</accession>
    <name>F4F8J2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="13" type="ordered locus">VAB18032_17165</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733192.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17165"/>
    <dbReference type="EnsemblBacteria" id="AEB44537">
        <property type="protein sequence ID" value="AEB44537"/>
        <property type="gene ID" value="VAB18032_17165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17165"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_11"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="OrthoDB" id="577156at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="8"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="418"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="20"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="423"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="423"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="507"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="686"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="718"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB44537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="745" mass="81116" checksum="B351C017BC8BC97F" modified="2011-06-28" version="1">MTTAFGQSTVLGYPRIGVDRELKKAVEAYWAGTIDVDALESTAAGLRAQVWRTLHDARLDAIPSNTFSYYDQVLDTAVAVGAIPTRFARLGLPALDTYFAMARGVDTEPALELTKWFDTNYHYLVPEIAPDTVFTANPAKALGEHAEARDLGITTRPVFIGPATFLLLAKGDDPFARLDDLVDTYAAILTALAEAGVAWIQLDEPAYVADRTPAEIDALRRAYIRLGELTHRPRIFVATYFGDLGAALPALLDTPVEAIGLDLVAGPGNLDRLAAAGPLAGRTIVAGLVDGRNIWRTDLRAAIAAGATVAGLADHVAVATSCSLLHVPVDLSAETRLDPRLAARLAFARQKVDEVVLLGRALRDGTTVLPAPLPPTPAAWHHDSVRGRLAALRPADRQRGDYPVRAARQQDRLRLPQLPTTTIGSFPQTTELRKARAAHRAGRLDDAGYASRMRAEVEHVIRLQERWGLDVLVHGEPERNDMVQYFGEQLDGFAATEHGWVQSYGSRCVRPPIIYGDVARRAPMTVEWSTYAQSLTSKPVKGMLTGPVTILAWSFVRTDQPVADTADQVALALRDECRDLESAGIRVIQVDEPALRETLPLRKADQKAYLDWAVGAFRLATSGVADDTQIHTHLCYSEFGEVITAIDALDADVTSIEASRSKMEILDDLAAIGYRRGVGPGVWDIHSPRVPPREEMVEALHRAVAAVPARRLWVNPDCGLKTRSYPEVEASLRHLVAAAAEVRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8K9</accession>
    <name>F4F8K9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Argininosuccinate synthase</fullName>
            <ecNumber evidence="6 15">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">argG</name>
        <name evidence="16" type="ordered locus">VAB18032_23270</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the argininosuccinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="6 15"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734404.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
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    <dbReference type="STRING" id="263358.VAB18032_23270"/>
    <dbReference type="EnsemblBacteria" id="AEB45752">
        <property type="protein sequence ID" value="AEB45752"/>
        <property type="gene ID" value="VAB18032_23270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23270"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_1_11"/>
    <dbReference type="OMA" id="GRAYFNT"/>
    <dbReference type="OrthoDB" id="357142at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00581">
        <property type="entry name" value="Arg_succ_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023437">
        <property type="entry name" value="Arg_succ_synth_type2_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024073">
        <property type="entry name" value="AS_multimer_C_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="17"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB45752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="483" mass="52680" checksum="950007CEEEDA783B" modified="2011-06-28" version="1">MSKVLTSLPIGERVGIAFSGGLDTSVAVAWMRDKGAIPCAYTADIGQYDEPDIASVPGRALNYGAELARLVDCRAALVEEGLAALTCGAFHIRSGGRAYFNTTPLGRAVTGTLLVRAMVEDDVQIWGDGSTFKGNDIERFYRYGLLANPQLRIYKPWLDADFVTELGGRKEMSEWLLERDLPYRDSTEKAYSTDANIWGATHEAKTLEHLDTGIETVNPIMGVRFWDLSVEIPTEDVTIGFDQGRPVTINGKEFASAVDLVLEANAIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHAAYERLVNAIHNEDTLANYHNEGRRLGRLMYEGRWLDPQALMLRESLQRWVGTAITGEVTLRLRRGEDYSILDTTGPSFSYHPDKLSMERTEDSAFGPQDRIGQLTMRNLDIADSRAKLEQYANLGMVGGGSPQRMVGAAQAASTGLIGAMPQGGAEAIASRGVAPAEDEALDRAAMEFGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8M3</accession>
    <name>F4F8M3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_23340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734418.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23340"/>
    <dbReference type="EnsemblBacteria" id="AEB45766">
        <property type="protein sequence ID" value="AEB45766"/>
        <property type="gene ID" value="VAB18032_23340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23340"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_11"/>
    <dbReference type="OMA" id="SGYMRDE"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="55"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="247"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="467" mass="49677" checksum="FA241EA4270AFF22" modified="2011-06-28" version="1">MTTLRVGGRTATATDRTHRPTLTSRAQIPAQPGPATPPRRHRILMLSWEFPPVLVGGLGRHVHALSVALVAAGHEVTVVTRHAEGAPLEEYVDGVRVVRAAEDPVTFPLATESLLAWTMAFNHTLTRAALRAVSTGGYDVIHAHDWLVAHTAMTLREHLDLPLVSTIHATEAGRHQGWLPEEMNRTIHGVEQWISTESTRVVVCSGYMRDEVTGLFGVPAGRVDVVPNGVEPHRWRVPASAVAQARARFAGDGPLVTFAGRLVYEKGVQHLLAGLPRLRDRHPGLRAVIVGDGPYRGELEADVHRLGLADTVSLPGFLGGTDLPAVMAASDCFAVPSIYEPFGMVALEGAAAGAPLAVAETGGLAEIVEPGVTGVTFRPHDPEALTDAVHTLLADTEHARALARRARAMVHEKYGWAAIASRTASAYASAIAQAPAVAAERAAQQMAHGRPRLTVPEGNLLAAAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8R6</accession>
    <name>F4F8R6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine N-alpha-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Histidine trimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">egtD</name>
        <name evidence="5" type="ordered locus">VAB18032_23555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:38471"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. EgtD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734461.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23555"/>
    <dbReference type="EnsemblBacteria" id="AEB45809">
        <property type="protein sequence ID" value="AEB45809"/>
        <property type="gene ID" value="VAB18032_23555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23555"/>
    <dbReference type="eggNOG" id="COG4301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049766_1_0_11"/>
    <dbReference type="OMA" id="RVEMHLV"/>
    <dbReference type="OrthoDB" id="775492at2"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030745">
        <property type="term" value="F:dimethylhistidine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02037">
        <property type="entry name" value="EgtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032888">
        <property type="entry name" value="EgtD_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="4">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-histidine binding" evidence="3">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="35347" checksum="4B53F42C7BB66297" modified="2011-06-28" version="1">MSAEPLEIHLDDRDVADSLRRDVRVGLSAEAKWLPPKWFYDARGSELFDEITQLPEYYPTRTERAVLAEHAAEIAELTGAKTLIELGSGSSEKTRLLLDAFTRRGGLGTFVPLDVSVSALRGSTAALAADYAGLRVRGIVGDFTRDLHRLPAGGRRLVIFLGGTIGNLLPAERAEFLARMRAALEVGDWFLVGTDLVKDPSVIVPAYDDAAGVTAEFNRNVLRVLNRELGADFDPEAFDHVALWDPEQEWIEMRLRAQRPMRVRVLDMAVDFAAGEQLRTEVSAKFRPEGIAAELAAAGLPAYRFWTDPDGLFGVTLARAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F916</accession>
    <name>F4F916_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730718.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04590"/>
    <dbReference type="EnsemblBacteria" id="AEB42044">
        <property type="protein sequence ID" value="AEB42044"/>
        <property type="gene ID" value="VAB18032_04590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04590"/>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056509_0_0_11"/>
    <dbReference type="OMA" id="IMERVGW"/>
    <dbReference type="OrthoDB" id="362657at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="111"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="408" mass="46007" checksum="42A7217A84BA51E6" modified="2011-06-28" version="1">MLSVEDWAEIRRLHRAERMAIKAICRRLGVSRNTVRRALASHEPPRYQRAAKGSIVDAVEPQIRALLAEFPDMPTTVIMERVGWTRGKTVFADRVQQLRPLFRRPDPSQRTEYLPGELAQCDLWFPPADVPLGFGQVGRPPVLVMVSGYSRWLSAVMIPSRQSADLLVGHWTLISGWGRVPKALVWDNESAVGQWRTGRPQLTEAMNAFRGTLGIKVIQCRPADPEAKGLVERANGYLETSFLPGRCFGSPQDFNAQLTEWLVRANNRQHRVLGCRPLDRWDADRAAMLPLPPVAPVVGWRQTTRLPRDHYVRVDGNDYSVHPSVVGRRVEVTADCDQVQVFCDGRSVTRHDRCWAKHQSITDPAHRQAAADLRVAAQRTPTTAVDAQVERRPLSDYDRLFGLDEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F943</accession>
    <name>F4F943_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04725"/>
    <dbReference type="EnsemblBacteria" id="AEB42071">
        <property type="protein sequence ID" value="AEB42071"/>
        <property type="gene ID" value="VAB18032_04725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04725"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_5_1_11"/>
    <dbReference type="OMA" id="RNRWSVE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="621" mass="65598" checksum="EA557DAAE18F2AAB" modified="2011-06-28" version="1">MSRTMTSSHDRSSGWIGSSGLADLLRGHRRAAGLTQAELATRAGVGVRTVRDLERGRSSRPQRTTVDLLADALDLSGAARTAFVAAARRADGGTARATAGEPTPVPPPPELIGRERDLAELVTLLTEPRGPRVISLVGVAGVGKTALALAACHAVAAARRASPVGPPSESGRPGGVSGLHVDVGSDVADVFAAALGAFGVSRTTELTARIGDPTLLVDAAERAPDSVAGAVQRLVDAVPSLRVLVTGRHPVGLPDEWVRPVLPLDVPASGDIDQSALAASPAVALFTARLAQVRREPPTETELPALAALVRRLGGLPLAIELMAARGRLLSLTELLDRYGDRVLDLDMATRSGWPTGQLRPDDTRAAVAGTLRDAVATSYRLLDDEERAALRRFSAFDNRWSIELAEEMLTGTAITADPVRLLNRFIELGLLHVRGDGPFRFRLLDAVRDYAVERVSGAGEAAVIQRRHARVITWFVERTAPGLTGADATGAARRLDEVSGDISAALAYAAVDDPLTALRLAAGLPLWWRLRGRAGAGRQWLLRLLADPRTAEADGELRLRASRGAASLADEQAAVVEDLPKARDRSRQRGVVARARKPPVATPRSSPAPAPPIAPPVTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F982</accession>
    <name>F4F982_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730784.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04920"/>
    <dbReference type="EnsemblBacteria" id="AEB42110">
        <property type="protein sequence ID" value="AEB42110"/>
        <property type="gene ID" value="VAB18032_04920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04920"/>
    <dbReference type="eggNOG" id="ENOG50324KP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196909_0_0_11"/>
    <dbReference type="OMA" id="RWRRICR"/>
    <dbReference type="OrthoDB" id="2065986at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="9335" checksum="F289A148545E3F05" modified="2011-06-28" version="1">MDGVERSPVGRRSGEGGYVRRVSYDEYLSATALTFARRHRPVWSWQRWRRVCRCGADLPCRARHRIPINRGHWPPESEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9H7</accession>
    <name>F4F9H7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733210.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17265"/>
    <dbReference type="EnsemblBacteria" id="AEB44555">
        <property type="protein sequence ID" value="AEB44555"/>
        <property type="gene ID" value="VAB18032_17265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17265"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008901_0_1_11"/>
    <dbReference type="OMA" id="CFLKDYA"/>
    <dbReference type="OrthoDB" id="983098at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="485" mass="52498" checksum="A1B8BB1530C968A0" modified="2011-06-28" version="1">MTVDNMTENGHQGIDRSQLETCLSVFEALEELPPDHPDVVRVQRATAKLYKMIKQRRRSERRDAILAADQAVTAATATGAPGRIDDETQGIPLASPTDGTTAGVLHNPRGCYICKQRYREVDAFYHQLCPPCAAFNRERRDARTDLTGRRALLTGGRAKIGMYIALRLLRDGAHTTVTTRFPHDAVRRFAAMPDSADWLHRLRVVGIDLRDPAQVIALADSVSDQGPLDILINNAAQTVRRTPQAYAHLVAAEAAALPDGPLPEMITFAKPADHSGPTGVLTAGPQTTITPHALTALALTSGSASPERIAAATAIDAGGLVPDLGAVNSWVQRVHEVDPVELLEVQLCNVTAPFVLVSRLRPAMAAATARRKYVVNVSAMEGQFARGYKGPGHPHTNMAKAALNMLTRTSAQEMLTDGILMTSVDTGWITDERPHPTKMRLADAGFHAPLDLVDGAARVYDPIVRGEQGEDLYGCFLKDYAPSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9M4</accession>
    <name>F4F9M4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733257.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17500"/>
    <dbReference type="EnsemblBacteria" id="AEB44602">
        <property type="protein sequence ID" value="AEB44602"/>
        <property type="gene ID" value="VAB18032_17500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17500"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OMA" id="KCPSWFA"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="436" mass="47807" checksum="060C0A1D4F7FE242" modified="2011-06-28" version="1">MLGFVVPGTSLKDRYRLGRFPLAHKGMGEVWSAHDALLDRPVIVKFVSPAMSDRDVVRRFRREALLTARLDHPGVPAVYDLGEHAGQPYVVLQKIDGITLTDLLAEQGPLPISWVAAIGAQVSSVLLAAQQIHLVHRDIKPSNIMLDTHGAAKVLDFGLAVIRDDERYSKITQTGQSMGTVGYMSPEQILGEHTDHRTDLYGLGATLFDLLTGHPPFDGVTTMTTVRHQIADPPPRPTQRRPDIPRAVDDLVHSLLAVDPDDRPDTAAEVYALLAPLARELPPIPGVLTDTVEAVQAYAAIVGRVPRPALLTSPTTSALAASDLEQSLEEAEHLHAAGEFRAAARRWRHLATQHEQLHGENHPLVFDLRLRAARAHIPLGEHGRASRQLDALLQERLRAAGPEDAVVLALRREIAHLMAQRQRLPRSRSDGPAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9U8</accession>
    <name>F4F9U8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23880"/>
    <dbReference type="EnsemblBacteria" id="AEB45874">
        <property type="protein sequence ID" value="AEB45874"/>
        <property type="gene ID" value="VAB18032_23880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23880"/>
    <dbReference type="HOGENOM" id="CLU_2107988_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="115" mass="12308" checksum="A01CEC44C6382B44" modified="2011-06-28" version="1">MISRPTNGYERTGSPTVRYRPGGRAVAGDGLWPGGGIPAGVDQTSDGKQFTGGEWAGGGAGRWPDLDPSGRSDRRWRVDGPWPRLPDDAPLWSVPDASGDDGAHRRRLDREQAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA03</accession>
    <name>F4FA03_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735760.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00150"/>
    <dbReference type="EnsemblBacteria" id="AEB47114">
        <property type="protein sequence ID" value="AEB47114"/>
        <property type="gene ID" value="VAB18032_00150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00150"/>
    <dbReference type="HOGENOM" id="CLU_184600_0_0_11"/>
    <dbReference type="OMA" id="RMDVRGV"/>
    <dbReference type="OrthoDB" id="2091268at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307755" evidence="1">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="95" mass="9872" checksum="DBF46ED8F1052B68" modified="2011-06-28" version="1">MESYINKRPTALPVAVAPLSAALTLAAAPLSVGRANVAAARPWAPQVHRVEVQAELILAPTQRGLQGISGFTGKGVDGAVKRMDVRGVPPRGRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAA2</accession>
    <name>F4FAA2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730837.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05185"/>
    <dbReference type="EnsemblBacteria" id="AEB42163">
        <property type="protein sequence ID" value="AEB42163"/>
        <property type="gene ID" value="VAB18032_05185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05185"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003609_6_0_11"/>
    <dbReference type="OMA" id="HAFDELF"/>
    <dbReference type="OrthoDB" id="2013820at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="724" mass="75399" checksum="B23D3DBFB0C278C0" modified="2011-06-28" version="1">MVDENADRVHVPGQHGVPERDIEPLWPPDQIDGFGTSGWDAPPPAPPVAPPPGGRPATSPGDHPPATHSATPGGYPAVPPSPADYPSLTGGGPSATGWAPVPTPPQPPVSADPDPGPAASAWGPGNGGSFSAPPTASGRATPVGPPPESGQVNLDLPFTLDPPTALTPSRDSGPRAVSDNVPAERGDAPDAGADSAAAESGDATSTTRPMESPWAQPPQRSGVATPSENGGRAEAAVGVPRPTWAGPAQPLPPVPSAPPDTLLSGTAVPQQPGPDQAAFPPPQRGSFPVPQHGVATPQHGDPVPHPPAPHGEPLPHPPAPQQGVVAGPETPVLQPGPFTAAVPPPADVRAPAAPHPGPGAPQVTPPYATPPGPFPPQPAWQPAPWQQQGPPAVPYQPTETAPRTGYADQGWTQETGGAPTAEDFARRRQVRPTDPVATMGVRAVVNKTGLVKLPPGRHELELKRDIEMVRRNFGGLRQVTVVNPKGGAGKTVAILLLAMTFGQKRGGYVLAWDNNETQGTLGMRAQQDFHSRTVRDLLRDLGQFHGAHGRVGDLSQYVRSQGEGMFDVLASDESATGGEMLTAAAFGEIREVVSRFYKLIFVDTGNNVRAQNWQAAMDATDQLVVTMSARNDSAETAARMLDHLEQSGRQRLVRQAVTVVSMPPSRKEIDLPAIQEHFAARTRAVLLAPYERLIDTGEPIRYAGLSAATRDAWLKIAAAVAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAA3</accession>
    <name>F4FAA3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730838.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05190"/>
    <dbReference type="EnsemblBacteria" id="AEB42164">
        <property type="protein sequence ID" value="AEB42164"/>
        <property type="gene ID" value="VAB18032_05190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05190"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862301_0_0_11"/>
    <dbReference type="OMA" id="KRSWWTE"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="35168" checksum="5764678C35A777DE" modified="2011-06-28" version="1">MYDVVLLTLGSERDASGAGCGSGEACCGGDVAATKDRDDRCETPRVPVLACADALTARGARVEAVTARSDAEIDDVLARLDGPARPDGLTWPDPDSKIRLVVAVAGDAQLRAVLRRLVRRYAPPPSRRPADLAGNRTVPDLPPIGVLPLDPARSTTHRDLAAQLGLPRDPAAVAAAVLDGTPRRLDLLRNDGGSVTLDGALLGAASEDGRPLHWRGRVEVDDAVLSDGDDPLLACVIGNAGGYARLDDVTLLADPDPSDGLVEVAVAVPVVTRSRLGRRRVRLEVRRARGRAASVLPRDEAALPYLDDGVQGELTRKRSWWTEPGAWAVWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAB1</accession>
    <name>F4FAB1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730846.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05230"/>
    <dbReference type="EnsemblBacteria" id="AEB42172">
        <property type="protein sequence ID" value="AEB42172"/>
        <property type="gene ID" value="VAB18032_05230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05230"/>
    <dbReference type="eggNOG" id="ENOG50333PX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1460718_0_0_11"/>
    <dbReference type="OMA" id="WDHRSTA"/>
    <dbReference type="OrthoDB" id="1962187at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="19459" checksum="84A0C6CB99DC5886" modified="2011-06-28" version="1">MLSSPVWRGLPALYFCLGLVAGGVVIAAALLLVGSLLRAPLPPPVRIGIVLVAALVVTLRELGVLRFPLPENKRLVPESVFRLGRFAGPFQFGLEMGTGVRTYLPSGLAYLTAVVLLLFATPLTAVAAGVGFGLGRSLMTTSALHFDDSGGWNLEWDHRSTAVTRVLLVGYLAALAVLVSSLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAE8</accession>
    <name>F4FAE8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RF_PROK_I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732046.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11285"/>
    <dbReference type="EnsemblBacteria" id="AEB43375">
        <property type="protein sequence ID" value="AEB43375"/>
        <property type="gene ID" value="VAB18032_11285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11285"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_3_1_11"/>
    <dbReference type="OMA" id="SEHRSQW"/>
    <dbReference type="OrthoDB" id="2047548at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="15619" checksum="9BAA4E0CF5065D76" modified="2011-06-28" version="1">MDDGLRVTDRWVVPAAELRERFSRSSGPGGQGVNTADSRVELSFDLAGSPSLPESLRARALDRLAGRLVNGVLTIAASEHRAQLANREAARERLVALLREAVAPPPPPRRPTRPSRGAKERRLADKKRRSQRKRDRRVDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAF4</accession>
    <name>F4FAF4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="14">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-IPM isomerase</fullName>
            <shortName evidence="14">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">leuC</name>
        <name evidence="17" type="ordered locus">VAB18032_11315</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="14"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11315"/>
    <dbReference type="EnsemblBacteria" id="AEB43381">
        <property type="protein sequence ID" value="AEB43381"/>
        <property type="gene ID" value="VAB18032_11315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11315"/>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_11"/>
    <dbReference type="OMA" id="CNMSIEM"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="16">
        <location>
            <begin position="3"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB43381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="471" mass="49759" checksum="52A65163E6192A9A" modified="2011-06-28" version="1">MAEKVWDAHVVRSVAGEPDLLFIDLHLLHEVTSPQAFDGLRLAGRPVRRTDLTLATEDHNTPTGYADPSFQQRRGDLLTIADPTSRTQIETLRRNCAEFGVKLHPLGDENQGIVHVIGPQLGLTQPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLPQARPKTMAVTVNGQLGPGVTAKDLVLALIAKVGTGGGRGHIVEYRGEAIRALSMEGRMTIANMSIEWGAKAGMIAPDETTFAYLKGRPNAPTGADWDAALAYWRTLPTDEGATFDAEVVLDAAEITPFVTWGTNPGQGAPLGAVVPDPEEFGTDAERAAARRALEYMDLRPGTPLRDLAVDVVFVGSCTNGRLEDLRAAADVLRGQRVAEGVRMLVVPGSAAVREAAEAEGLDKVFTDAGAEWRFAGCSMCLGMNPDTLSPGQRSASTSNRNFEGRQGRGGRTHLVSPPVAAATAVAGRLAAPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAI3</accession>
    <name>F4FAI3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="19" type="ordered locus">VAB18032_11480</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732080.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11480"/>
    <dbReference type="EnsemblBacteria" id="AEB43410">
        <property type="protein sequence ID" value="AEB43410"/>
        <property type="gene ID" value="VAB18032_11480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11480"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_1_2_11"/>
    <dbReference type="OMA" id="GVHLRMT"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AEB43410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="31500" checksum="AFE08BDFBAA5E285" modified="2011-06-28" version="1">MPELPEVETVRQGLARWVTGRRIESVEVRHPRAVRRHVAGGAHFADVLAGRTVLDVCRRGKYLWLPLDSGDAVIGHLGMSGQLLLQPATAPEEPHLRVRFRFTDDGPELRFVDQRTFGGLSVSEGGATLPAEIAHIARDPLDPQFSDADFVTAMRRRRTEVKRALLDQTLISGVGNIYADEALWRAGLHGTRPTDALTGPAVRRLLGHVRDVLTEAITAGGTSFDALYVNVNGQSGYFDRSLNVYGREGQPCRRCGAPIRREAFMNRSSYSCPRCQPRPRATLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAN4</accession>
    <name>F4FAN4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733304.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17735"/>
    <dbReference type="EnsemblBacteria" id="AEB44649">
        <property type="protein sequence ID" value="AEB44649"/>
        <property type="gene ID" value="VAB18032_17735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17735"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="OMA" id="RRMDTGQ"/>
    <dbReference type="OrthoDB" id="618655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="14"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="472" mass="49359" checksum="C0EA45BDF5765395" modified="2011-06-28" version="1">MESVRTDFYLDGAWVPADGRQSLEVHNTSTEQVIGTVPAGTADDVDRAVAAARAAFEGWAATDPVDRAAHLDRLHAELTARAGDIAHTVATELGTPLKVATRVQVGLPLTVLRSYVDLAAQPPAPQTVGNSLVVREPVGVIGAITPWNYPLHQIVAKLAPALAAGCTLVLKPSELTPLTAYLLFDAIDAASLPPGVVNLVTGTGPIVGEALAGHPDVDLVSFTGSTATGRRIAHLAADRIARVALELGGKSANVILDDADLTAAVKVGVGNAMLNSGQTCTAWTRMLVHRDRYDEALDLAATAVAGYRLGDPFDPATRLGPLVSAAQRDRVREHIARGLADGGRLVVGGPDAPVPSRGWFVAPTIIADVDPDSALAQEEVFGPVLAVIPVDDDDHAVRVANNSRYGLAGAVWSTDEERAVQVARRLRTGAVDINGAPFNPLAPFGGYKQSGLGRELGTHGLAEFCELKAIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAT5</accession>
    <name>F4FAT5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733355.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17990"/>
    <dbReference type="EnsemblBacteria" id="AEB44700">
        <property type="protein sequence ID" value="AEB44700"/>
        <property type="gene ID" value="VAB18032_17990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17990"/>
    <dbReference type="eggNOG" id="COG2746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060091_0_0_11"/>
    <dbReference type="OMA" id="HATDCRL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="28392" checksum="58A915EF51D9D023" modified="2011-06-28" version="1">MINTDLPATRAALADNLASLGVRRGSVLLVHSSLKALGWVCGGPVAVVQALLDAVGPDGTLVVPTLAPANTDPGGWQNPPVPEPWWPVIREHMPAFDPAVTPSQWMGVIAETVRTWPGAQRSDHPQVSFAALGPAAEAVVTGHQLDDMLGERSPLGAVYRLDGDVLLLGVGHGNNTSLHLAEYRVPDPPRRQESSAVRTDTGQRWARWEDVATDEGDFDQLGAAFEATGRARIGQVGAAESRLMRQRELVDFAVDWLATHRPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAV0</accession>
    <name>F4FAV0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734565.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45913">
        <property type="protein sequence ID" value="AEB45913"/>
        <property type="gene ID" value="VAB18032_24075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24075"/>
    <dbReference type="eggNOG" id="ENOG50323AB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185223_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="77" mass="7628" checksum="C58272649DF64AFA" modified="2011-06-28" version="1">MTTDPRYTPIAVTAAGKLVADGGDTAGGEAVGADDAAADAARAGADIDLSEARRDTDPTPVGAADAEADRRRAAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAV8</accession>
    <name>F4FAV8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spoom family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24115"/>
    <dbReference type="EnsemblBacteria" id="AEB45921">
        <property type="protein sequence ID" value="AEB45921"/>
        <property type="gene ID" value="VAB18032_24115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24115"/>
    <dbReference type="eggNOG" id="COG4326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057336_0_0_11"/>
    <dbReference type="OMA" id="YQGTDWA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
        <property type="entry name" value="PTHR40053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="36576" checksum="AD51581724A58693" modified="2011-06-28" version="1">MLVVFKKMLGAFGIGAPSVDTVLSNPSTRPGLMLGGQVNLTGGSHDVDIDQIVVGLVTRIEIDGEEGDHDATVEFHRTPVAGGLRLAQGQQLSLPFQVQMPIQTPVTDVYGQRLPGMTMGLRTEVVIRGAVDKGDLDPVHVHPLPVQERILEAFGRLGFQFKGADLERGQIAGVHQTLPFYQEIEYFAAPQYAHGVTEVEVTFLADEQGMDIVLEFDRRGGLFTGGHDSYGRYRVAHADAERLDWAAVVDGWLREALEQYRATQPGYGTPGYGQPGYGYPPHQPAYGHDHDHHGRSGPGMGAVAAGVVGGAALGFAGGMVAEEVFDAFGDDGGDDGGDDGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB30</accession>
    <name>F4FB30_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="5">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cysC</name>
        <name evidence="8" type="ordered locus">VAB18032_00455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735820.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00455"/>
    <dbReference type="EnsemblBacteria" id="AEB47175">
        <property type="protein sequence ID" value="AEB47175"/>
        <property type="gene ID" value="VAB18032_00455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00455"/>
    <dbReference type="eggNOG" id="COG0529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_0_1_11"/>
    <dbReference type="OMA" id="WHTPPAV"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="7">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="6">
        <location>
            <begin position="134"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="334"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="509" mass="55575" checksum="B2AFFC31A35A94D9" modified="2011-06-28" version="1">MSNGWVLPDEILRDAPAYTPRPGELADLELLLTGAYAPLTGFLTRADLVSVSRRGRLVDGTPWPVAVTLQVPTALLREFDLADPNRRTLVLTDGEGAPVAALEVTDTWQVRDGVAGVGGRVRRLGDGGHGPFQRLRRTPEEIRALLPPGRVLGVVADRPLHRPQLAQIAHAVRTLSAHLLIMIPVGEDGTGGLPPEALVRCVFAARDRMPPATVVAVPLARRRDEIGDALLRARVSAAYGVTHLLSTSEMLSGGGLRVLVPRELAYDNRDGQWRWREDIPPRNRRLPLTYNEIEDLLDRGFPLPEWHTPPAVAKELSRARPPRRHRGLVVFLTGLSGSGKSTIARGLADALREQGERTITLLDGDVVRRELTAGLGFSKADRDTNVRRIGWVAAEIARHRGIGICCPIAPYAQARATAREMAVAAGAGFVLVHVATPLEVCERRDRKGLYARARAGLLTGMTGIDDPYEEPTDADLVIDTSDLDVDEAVQQVLHHLTETGWIEPRLQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBI2</accession>
    <name>F4FBI2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase subunit ChlI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732113.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11650"/>
    <dbReference type="EnsemblBacteria" id="AEB43444">
        <property type="protein sequence ID" value="AEB43444"/>
        <property type="gene ID" value="VAB18032_11650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11650"/>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026145_1_0_11"/>
    <dbReference type="OMA" id="STNPCPC"/>
    <dbReference type="OrthoDB" id="581802at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="210"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="505" mass="52663" checksum="575F22FADA256AA3" modified="2011-06-28" version="1">MSYARVLCVGLVGVTGHLVEVEADLAPGLPAVVISGLPDTALHEARDRVRAAVVNSGQRWPNRRITLNLLPATLPKFGSAFDLAIAVALLGGSGELPLAPLDGVVILGELGLDGTVRPVRGVLPMAAAAARAGVERVIVPAANSAEAAVVPGLRVRGVDTLHRLIAFVRDGAPLIEPPTHVPAPATSGPDLAEVAGQGLGRRALEVAAAGGHHLALIGPPGAGKTMLAERLPSILPELDDDAALEVTALHSIAGLLPADGGLLRRPPFQAPHHTATIPAIVGGGPGLARPGAISLAHRGVLFLDEAPEFSRAALEALRQPLEHGRVHLARSRGGAEYPAQAQLVIAANPCPCANPAGDDRCECPPQARRRYLARLSGPLLDRIDLQVRLLPMRAAELMEAGTQESSTAVAARVVAARAAAADRWSALGRRLNAEVPGTRLRRPPWQLPAADTAELRARLDSGSLSARGFDRVIRLAWTIADLDGRARPDRHDVGEAIHLRTGEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCB2</accession>
    <name>F4FCB2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmJ</name>
        <name evidence="6" type="ordered locus">VAB18032_01035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012184307.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="SMR" id="F4FCB2"/>
    <dbReference type="STRING" id="263358.VAB18032_01035"/>
    <dbReference type="EnsemblBacteria" id="AEB47291">
        <property type="protein sequence ID" value="AEB47291"/>
        <property type="gene ID" value="VAB18032_01035"/>
    </dbReference>
    <dbReference type="GeneID" id="5704893"/>
    <dbReference type="GeneID" id="67457609"/>
    <dbReference type="KEGG" id="vma:VAB18032_01035"/>
    <dbReference type="PATRIC" id="fig|391037.6.peg.4331"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_11"/>
    <dbReference type="OrthoDB" id="2066169at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="37" mass="4415" checksum="C921349F436F6B6F" modified="2011-06-28" version="1">MKVKPSVKRICNKCRVIRRHGRVMVICTDPRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCC0</accession>
    <name>F4FCC0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">rpsE</name>
        <name evidence="12" type="ordered locus">VAB18032_01075</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735940.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01075"/>
    <dbReference type="EnsemblBacteria" id="AEB47299">
        <property type="protein sequence ID" value="AEB47299"/>
        <property type="gene ID" value="VAB18032_01075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01075"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_1_2_11"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="37"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="20565" checksum="FC52DA059CAE1D19" modified="2011-06-28" version="1">MPGQQRRGGGSGGNEGGRRDNRREGGRGNAPAEKTPHLERVVAINRVAKVVKGGRRFSFTALVIVGDGDGTVGVGYGKAKEVPAAIAKGVEEAKKHFFKVPRIGSSIPHPVQGEAAAGVVLLKPASAGTGVIAGGPVRAVLECAGIHDVLSKSLGSSNPINIVHATVAALKGLESPEAVAARRGLPVEDVAPAAMLASRAGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCR2</accession>
    <name>F4FCR2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoOM family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732225.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12210"/>
    <dbReference type="EnsemblBacteria" id="AEB43556">
        <property type="protein sequence ID" value="AEB43556"/>
        <property type="gene ID" value="VAB18032_12210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12210"/>
    <dbReference type="eggNOG" id="COG4326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057336_0_0_11"/>
    <dbReference type="OMA" id="RFRVWHA"/>
    <dbReference type="OrthoDB" id="1033384at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
        <property type="entry name" value="PTHR40053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="32285" checksum="77C2A20912430F80" modified="2011-06-28" version="1">MRLTGVSPGGTGLTVQTALANPSTRPGLRLPGRVNLIAGSVDVPVYHVRLGLVSTVEPDDPEAPRRLVQFHQAQVSDALVLRAGRARSIPFEFPLPWETPVTTLGGVPLLSLRMGLRTEVAIEPALDQGAMVPIFVHPLPTQQHILGALDTLGFSARQSGLIDGRLPGVEQTLSLHQRWGFWVGPLYAGPITELEVIFVTNSAGLEVIFWCDRRLALAGITHTSISRFRSWHVDADKRDWTATVDGWLRETINRHAAAAAHADWSANISESAHVSRPPDQPIPPGYGLGGTAGGAGTGGDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCR9</accession>
    <name>F4FCR9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10 11">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10 11">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">recA</name>
        <name evidence="15" type="ordered locus">VAB18032_12245</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732232.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12245"/>
    <dbReference type="EnsemblBacteria" id="AEB43563">
        <property type="protein sequence ID" value="AEB43563"/>
        <property type="gene ID" value="VAB18032_12245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12245"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019600_1_0_11"/>
    <dbReference type="OMA" id="MAPSMEY"/>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03161">
        <property type="entry name" value="LAGLIDADG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="12">
        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="14">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="13">
        <location>
            <begin position="564"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB43563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="712" mass="77494" checksum="4CE16BBAACE7B7BD" modified="2011-06-28" version="1">MAAGPDREKALDLALAQIDKQFGKGSVMRLGERPVVQTAIIPTGSIALDVALGVGGLPRGRVIEIYGPESSGKTTVALHAVANAQRNGGIAAFIDAEHALDPEYAKALGVDTDALLVSQPDTGEQALEIADMLVRSGALDIIVIDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKITGVLNNTGTTAIFINQLREKIGVMFGCMSYSTRVTLADGTQEKIGKIVNQRLDVEVLSYNPDTDRVEPKRITNWFNNGPAEQFLQFTVAKSGGNGRAQFAATANHLVRTPGGWREAGELIAGDRVMLAEARRLSEQQWQVVLGSLMGDGALSPNRQDRNGVRFRLGHGEQQVDYLDWKVSLLGNISHSRRTDSRGAAFVDFTPLSELGELRRAVYLGDGKKHLSWDYLKALTPLALAVWYMDDGCFTLRSKGVQARTAGGSGRIEICVEAMAEGSRERLVEHLRDAYGMDVKLVSRGARQTASIIFTTEASAKFQELIAPYVPAAMESKLLPRFRGQCVVEPQFVPEEIMPVPARIIDVRVKPKTRSMNRFDIEVEGNHNYFVDGVMVHNSPETTTGGRALKFYASVRLDVRRIESLKDGTDVVGNRTRVKVVKNKVASPFKQAEFDIMYGKGISREGSLIDVGVEQAIIRKSGAWYTYEGDQLGQGKEKAREFLRENPDVAAEIEKKILEKLGVGVGAGDAAGGPELPPVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCU1</accession>
    <name>F4FCU1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732254.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12355"/>
    <dbReference type="EnsemblBacteria" id="AEB43585">
        <property type="protein sequence ID" value="AEB43585"/>
        <property type="gene ID" value="VAB18032_12355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12355"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024630_1_0_11"/>
    <dbReference type="OMA" id="DELWHRF"/>
    <dbReference type="OrthoDB" id="1230240at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="355"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="44560" checksum="56D2C873478D18F2" modified="2011-06-28" version="1">MSDWTAFGRVDADGTVYVKTAEGERVVGSWQAGAPEEGLAHFARRFADLVTEVNLTEARLNSGAADANHSLATVRRIRASLADAHVVGDIDALAARLDRLATVAEEKAGEAKAAKEAARSEALARKTALVEEAEKLAAESTGWKTAGDRLKEILDEWKTIRGVDKKTDGELWKRFAAARDGFTRRRGAHFASLDAQRKQAQTIKEELVAEAEKVSDSTEWASAANQLKDLMNQWKAAPRASKEAEQRLWEKFRAAQDAFFTRRSEVFSARDNEQRANLERKQALLAEAEALDIDGDPKGAQAKLRDIQAQWHEAGRVPREAAAGLERRLRAVDEKVREVMDSAWRRTSREDNPLLAQMRAQVAEAEERLARAQAAGDNRRIKEAEQALASKRQFLQLAEQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCY1</accession>
    <name>F4FCY1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18555"/>
    <dbReference type="EnsemblBacteria" id="AEB44813">
        <property type="protein sequence ID" value="AEB44813"/>
        <property type="gene ID" value="VAB18032_18555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18555"/>
    <dbReference type="eggNOG" id="ENOG5033EFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157925_1_0_11"/>
    <dbReference type="OMA" id="VMAISHK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="11665" checksum="BC1042A58293B906" modified="2011-06-28" version="1">MSLSDVYYNSLARVTTLLAAPDPAGGGGTVPQPSINGTLPDGLSQKVQQVLSLIAWGGTAAGVVGILITGAVMAISHKRGESSEHMSRLGMVLGGCILVATAGPIVSWVFGTGSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDH6</accession>
    <name>F4FDH6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01515"/>
    <dbReference type="EnsemblBacteria" id="AEB47387">
        <property type="protein sequence ID" value="AEB47387"/>
        <property type="gene ID" value="VAB18032_01515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01515"/>
    <dbReference type="HOGENOM" id="CLU_3259460_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="42" mass="4218" checksum="BA20A4E026E3F2B1" modified="2011-06-28" version="1">MESTLADHNLVKGGAFLVAACGPALVGLALTFGIITENMITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE64</accession>
    <name>F4FE64_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4253 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733588.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19155"/>
    <dbReference type="EnsemblBacteria" id="AEB44933">
        <property type="protein sequence ID" value="AEB44933"/>
        <property type="gene ID" value="VAB18032_19155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19155"/>
    <dbReference type="eggNOG" id="ENOG5032XD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092809_0_0_11"/>
    <dbReference type="OMA" id="WATGELY"/>
    <dbReference type="OrthoDB" id="1887623at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4253" evidence="1">
        <location>
            <begin position="164"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="29416" checksum="0FF901E47E23BD69" modified="2011-06-28" version="1">MPTDLLELFPDGAPRTLAVPLPPGRTVRGSEGADERPVLWMSEEPAPAGLWSRLHAAHESSGLWPLLLDGLGGDMSRPWQGGELWQATSTPDQHDAERVLAGRWADQTGDGDDSPPPAEEDSFVAPYGRAWPGLAPALPPRVAVREHADHWAEQLSQALSEAHLGLVPAQRSSDVLAAVGWHGAINHIGVAELCAVLRSWEDRFGVRVIGAGFAELYLSVAAPPSTLDEALPIAAEHFAFCPDNILQGQRPYTVAAYAERLVDAPTWAFWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE66</accession>
    <name>F4FE66_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733590.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19165"/>
    <dbReference type="EnsemblBacteria" id="AEB44935">
        <property type="protein sequence ID" value="AEB44935"/>
        <property type="gene ID" value="VAB18032_19165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19165"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104057_0_0_11"/>
    <dbReference type="OMA" id="PMSFVQA"/>
    <dbReference type="OrthoDB" id="1115365at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="187" mass="20847" checksum="1649D20C6A00911E" modified="2011-06-28" version="1">MPGTSESVTYLIVDGENIDATLGNSVLERRPAPAERPRWERLREFARDTWRQPVKGLFFLNASGGALPMPFVRALLSMDYRPIPLAGSSDQKVVDIGIQRTLEAIARRSGNVMLASHDGDFLPQLGELLEGDRQVAVVGFKEFLNAGFAELPGLQVFDIEEDADCFTNVLPRVRIIDLESFDPERFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEB4</accession>
    <name>F4FEB4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25410"/>
    <dbReference type="EnsemblBacteria" id="AEB46180">
        <property type="protein sequence ID" value="AEB46180"/>
        <property type="gene ID" value="VAB18032_25410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25410"/>
    <dbReference type="eggNOG" id="ENOG502ZHD4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1947938_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313841" evidence="1">
        <location>
            <begin position="28"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="129" mass="14128" checksum="1A83DCFECB311B91" modified="2011-06-28" version="1">MLKTMLKSLAVAAAVAGVLATAPPASAAPAQASDGMWPSGNCPQGVFCLWPEWNEWMTPALTTNTDWSGEIPGYLFYNNTSRNVDITFRWQHDSPWGPFTICLTPGNGQDTYWPGIVTNVKVHTQPCVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEG1</accession>
    <name>F4FEG1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ordered locus">VAB18032_01595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736038.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01595"/>
    <dbReference type="EnsemblBacteria" id="AEB47403">
        <property type="protein sequence ID" value="AEB47403"/>
        <property type="gene ID" value="VAB18032_01595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01595"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_11"/>
    <dbReference type="OMA" id="ANRMEHA"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="27"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="35063" checksum="0C5449667DA1F2EB" modified="2011-06-28" version="1">MSTGELILGIESSCDDTAAAVVAEDGTVLSSVIVSQASLHNRYGGVYPEVASRAHVDKAIPAVRMAIEDAGIRPKDLRAIGVTRGPGLIGSLMVGVDTARGLGQGWGLPVLGINHLRGHLRSADLNERRVSYPALILLVSGGHTLLAHMRDQDTISLVGSTRDDSVGEAYDKVARMLGLGYPGGPVIDRLALQGQDRFGLPRPMLGDGLNFSFSGLKTAVRRLLESDPNLEAADVAASFVAACLDVLTQKCERALVEYPSESLVIVGGVAASPQLREVAGKLCESLDVKLCLPPLKWSTDNAAMIALAAWDYVRAGQGTDLAPTSRLSIEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEG4</accession>
    <name>F4FEG4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01610"/>
    <dbReference type="EnsemblBacteria" id="AEB47406">
        <property type="protein sequence ID" value="AEB47406"/>
        <property type="gene ID" value="VAB18032_01610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01610"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105441_0_0_11"/>
    <dbReference type="OMA" id="WAHTQGV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="184" mass="20150" checksum="106BCABD5E88566A" modified="2011-06-28" version="1">MGSLLLRAAEAAERNLAVALPRRWRHVRAVAAKAASIGPLVGADVEELAAAAWLHDIGYAPGIVDTGFHALDGARWLVREGYETRLASLVAYHSCAVYEAAERGLRDALLSEFPQEESSTSDALWYADMTTGPDGQNFTVDERLSEIRQRYGPDDLVTRFWVQAEAPLLRAVARTCSRITGQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEX6</accession>
    <name>F4FEX6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12870"/>
    <dbReference type="EnsemblBacteria" id="AEB43688">
        <property type="protein sequence ID" value="AEB43688"/>
        <property type="gene ID" value="VAB18032_12870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12870"/>
    <dbReference type="eggNOG" id="COG4315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053665_0_1_11"/>
    <dbReference type="OMA" id="CAEIWPP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307859" evidence="2">
        <location>
            <begin position="26"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="225" mass="23344" checksum="A061CFEB5A5DF810" modified="2011-06-28" version="1">MKRTVVVASAMVALTACAPAGYNGADPGVAEPVAVAAADSTATPDPESSADPEASAEPGASASPGAEPEADAPLPDGVELTESLTGKKFPRMGSAVVNQDGFLLYRFDRDSNDPPATNCEDQCAEVWPPALTDGNPKLKGVSDDAVGTITRPDGTRQITLDGWPLYTYIGDKKPGQWKGQGVGGTWFVVNPDGSKNLECLPKGTPKAVEPPSKTKSDSSDSDYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF07</accession>
    <name>F4FF07_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13025"/>
    <dbReference type="EnsemblBacteria" id="AEB43719">
        <property type="protein sequence ID" value="AEB43719"/>
        <property type="gene ID" value="VAB18032_13025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13025"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_3_11"/>
    <dbReference type="OMA" id="RWYAPTG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="19661" checksum="59EA06299D96770B" modified="2011-06-28" version="1">MANTRTADVAQAAGVSQALVFYHFATKERLLAQAFAYAVEQDLARLDAITRSNAPPLTKLRRILRLYTPTGRPTSWSMWIDGWSESLRTPELEKLSRRLDLRWRQDLAAVISDGVREGVFECADPAGAAWRISAVMDGLAVQLAVHERVISRRQFAEWVRLVAARELGLDPTQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF35</accession>
    <name>F4FF35_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13165"/>
    <dbReference type="EnsemblBacteria" id="AEB43747">
        <property type="protein sequence ID" value="AEB43747"/>
        <property type="gene ID" value="VAB18032_13165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13165"/>
    <dbReference type="eggNOG" id="ENOG5033ACW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255401_0_0_11"/>
    <dbReference type="OMA" id="FRWIFVE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="254" mass="29818" checksum="3D9E41CF27A97A49" modified="2011-06-28" version="1">MDSSSPVRRSDNGDDDPSVVGVLARGVVLVMVLPFRLAWELLAAVGKGLYRWVLAPTGRFLDRWLLRPLGWLLQHLIWIPLLWLGRAAGWLWQTLVWLPLTWLWQGLVWLWHHVLWPPLRWCARGLAWLFHTLVWVPLYYLVWVPVTWLVRVLTPAWQQVGRWLVVVGGHLGAALSWAWWASGRILWWCWALTLRPLWLATRWLWRNMVVPVGRAIRAVWRFTVVAPARWLRTSVLEPVGREIRKTLFALGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF42</accession>
    <name>F4FF42_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_19225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19225"/>
    <dbReference type="EnsemblBacteria" id="AEB44947">
        <property type="protein sequence ID" value="AEB44947"/>
        <property type="gene ID" value="VAB18032_19225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19225"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_11"/>
    <dbReference type="OMA" id="MQGVFGN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313860" evidence="8">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="34177" checksum="FA84E13FE7F360FA" modified="2011-06-28" version="1">MRRAALVAGLAVTLLLLCLVAAGTGQVRVPPAEVLGSILHRIGLDIGPTPSVTHGESALWVVRFPRVVLAVIVGAALGCAGALMQGVFGNPLAEPGVIGVSSGAAVGAATVIVTGAATFGGWTVAAGAFLGGLAATGLVYSMSRVGGRTEVVTLVLTGIAVNAVAGALIGLLMFFGDADAVRAIAFWQLGSLAQANWAAVAVTAPCAAVGIAIAVAAARRLDLLALGDRSARHLGVHVERLRLGMVAVTALLGAAAVAFTGVISFVGLVVPHLVRMVAGPGHRLLLPASALGGAIVVVAGDLAARTLVDYQELPLGVLTAVVGGPCFFWLLRRTRARAGGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF62</accession>
    <name>F4FF62_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733622.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19325"/>
    <dbReference type="EnsemblBacteria" id="AEB44967">
        <property type="protein sequence ID" value="AEB44967"/>
        <property type="gene ID" value="VAB18032_19325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19325"/>
    <dbReference type="eggNOG" id="ENOG50346G6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019217_0_0_11"/>
    <dbReference type="OMA" id="TDTCWEV"/>
    <dbReference type="OrthoDB" id="2031639at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="28525" checksum="219714C4C857918C" modified="2011-06-28" version="1">MSFDNQLDDALRALARDGGQDSRIPAATDIRRRGEIRRRRRRTASVALAATAVVALGAGVALARLGGSTQSMPIDPAGPSTVIGPSTSPSVDPSRPSTSPTGSPDSSTGSPDSPDSSTSSPAVPPSTDRLLSGTRQVAIVRTDAFESAVSMLDDGRLAEVDGVEGRRLFVITPQGPGTYQIRTAADPDTDLTDTCWEVRSAGSQPLRVEGVPCDQDEPRQRFSLDPAAGGTYLISSNSAYLQNSPTRGLILEEAGDAPVTARFRLVDNGPAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFB2</accession>
    <name>F4FFB2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ricin b lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_19575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19575"/>
    <dbReference type="EnsemblBacteria" id="AEB45017">
        <property type="protein sequence ID" value="AEB45017"/>
        <property type="gene ID" value="VAB18032_19575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19575"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_1_1_11"/>
    <dbReference type="OMA" id="LPLVWQW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309315" evidence="4">
        <location>
            <begin position="26"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="5">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="681" mass="74560" checksum="088C07E82EAC96FA" modified="2011-06-28" version="1">MWAAVAAAVMVGGTLVAVAATPASAATVDTNAWYVLVNRNSGKALDVYNLATNDGARITQWSRNDGNQQQWQFVDSGGGYYRLKSRLSGKVLDVYNFSTANGASIVQWSDHNGTNQQFRLADSAGGYVRLINRNSNRVMEVQNASTADGGNIVQYDDWNGANQQWQLVRVGDGPTPGPTTPPPTGGNFTNPVVWQDFADVEVIRVGDVYYMTASTMHYSPGAPILRSWDLVNWEFAGHSVPRLDFGTKYDLPPGQQAYVEGIWASTLSYRPSNQTYYWAGCINFAQTHIYTAKAVDGTWTRHATLPCYYDAGMLIDDNDTMYVAYGNGTISVAQLSADGRSQVRAQQVYQTPSSIGTLEGARFYKRNGAYYIWLTRPANGQYVLKSTNGPFGPYEQRQVLLNMQGPISGGGVPHQGGLVQTPNGAWYYMAFTDAYPGGRVPTLAPITWTADGWPQVQTVNGAWGVNYPNPLPLRPVKPLTGVDTFAGTTLGPQWEWNHNPDNSRWSVNNGLRLQTASVTNDLYQARNTVTHRIQGPTSTATVELDYSTMRDGDRTGLAMLRDVSAWIGVRRDNGQTRVVMTNGLNMNSNWDTTSTGSEIASAAVSGGRIWLRANADIRPGSGRQARFSYSTDGVNFVSLGNALTLNNNWTFFMGYRFAIFNHATQALGGAVTVRRFELATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFL7</accession>
    <name>F4FFL7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736128.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02050"/>
    <dbReference type="EnsemblBacteria" id="AEB47494">
        <property type="protein sequence ID" value="AEB47494"/>
        <property type="gene ID" value="VAB18032_02050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02050"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074072_1_1_11"/>
    <dbReference type="OMA" id="AHEPPDD"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="23163" checksum="59341FBDFFB2259D" modified="2011-06-28" version="1">MATSKDLPDVGGFIRDLRRNAKISLRQLAEQAGVSNPYLSQIERGLRRPSAEVLQQLASALRVSTPAMYLRAGLLDDKEGQGVLAAIAVDPDLTMAQKQSLTQIYETFRRENARLAEATAAAADAAPGGPATATPGGTATTGSAPVGPVHGTDTSGEEIVPITAPDVANLAATGPTTPEGTPTEAVLESVAVTEAGPAPAPARPPAKKAARKVVRKAAVAAEEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG27</accession>
    <name>F4FG27_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43771">
        <property type="protein sequence ID" value="AEB43771"/>
        <property type="gene ID" value="VAB18032_13295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13295"/>
    <dbReference type="HOGENOM" id="CLU_3241123_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="43" mass="4851" checksum="791639C77BF5E154" modified="2011-06-28" version="1">MPIAQLSSGDSERLRRVLHDLWRALGVGLPYDDVSGTEPHHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG61</accession>
    <name>F4FG61_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="5" type="ordered locus">VAB18032_13465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732472.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13465"/>
    <dbReference type="EnsemblBacteria" id="AEB43805">
        <property type="protein sequence ID" value="AEB43805"/>
        <property type="gene ID" value="VAB18032_13465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13465"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_3_1_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="40" mass="4615" checksum="C0CD9BC06F4222A6" modified="2011-06-28" version="1">MKVRSSLRSLKQKPGSVVVRRRGRVVVLNRANPQWKSRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGA1</accession>
    <name>F4FGA1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19685"/>
    <dbReference type="EnsemblBacteria" id="AEB45039">
        <property type="protein sequence ID" value="AEB45039"/>
        <property type="gene ID" value="VAB18032_19685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19685"/>
    <dbReference type="eggNOG" id="COG1819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_7_1_11"/>
    <dbReference type="OMA" id="MFSIAAH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="385" mass="41266" checksum="C2359B973F52D529" modified="2011-06-28" version="1">MVGCTAPSHIYPSLALIRELVDRGHRVTYVVGEPLTGLVAPTGAEPIAHPTILPQGDTPWPEDPATAMRVFLDEGIAVLPQVTARYDADRPDLVLYDIGGLPGPLLGERYGVPAVQLSPTMVAWTGYEQDMAEFFTALTSSASGRDYYATFDAWLADHGIHQDSRTFVTFPQRVLSLIPRVMQPNADRVPETVRFVGPCLDPARLTEPGWTPPTDGRPVLLVSFGTAYNDQLPVYRACLEGFADSPWHVVIAIGDKVDPADLGPLPGNVEVHRRVPQLVVLAHASAFVTHAGMGGCTEALWFGVPTVAIPQAVDQFANAQQLADAGLGRLLPAEEVTAETLRAAVDAVADDTALRGRLTEAQAEVRADGGTAKAAHAVESYLTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGA5</accession>
    <name>F4FGA5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733698.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19705"/>
    <dbReference type="EnsemblBacteria" id="AEB45043">
        <property type="protein sequence ID" value="AEB45043"/>
        <property type="gene ID" value="VAB18032_19705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19705"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_7_0_11"/>
    <dbReference type="OMA" id="LHIPKAT"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="72"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="261" mass="27340" checksum="C9AD4D9DEFEEA1DE" modified="2011-06-28" version="1">MAGGSRSPGASVTSRVLAVLGAFDAAHPALTLSDIARRSGLPLATAHRLVAELVTGRALARGVDGTYRIGVRLWEIGLLSPLHGQLREVALPYLQELYTTVRENVHLAVRDGDEALYVEKVTGHRAVPTISRAGGRLPLHATGVGKALLAYAPPEVIAAHLRGPLRRCTPYTIVEPGRLARELAAIRERGWARTHEEMTLGSCSVAVVVPGPDGAALAAIGVVGHSLGAAPQRLVPALRAAADQVAARLADEPHATQRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGB0</accession>
    <name>F4FGB0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protocatechuate 3,4-dioxygenase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733703.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19730"/>
    <dbReference type="EnsemblBacteria" id="AEB45048">
        <property type="protein sequence ID" value="AEB45048"/>
        <property type="gene ID" value="VAB18032_19730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19730"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_7_1_11"/>
    <dbReference type="OMA" id="YRFDIHL"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03463">
        <property type="entry name" value="3_4-PCD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012786">
        <property type="entry name" value="Protocat_dOase_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02423">
        <property type="entry name" value="protocat_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="38"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="189" mass="20558" checksum="25750FC7455FC580" modified="2011-06-28" version="1">MSERLDVTPAQTVGPYLHIGLSWPDGPYVVPEGTPGAFWIRGRIVDGTGAPVGDAMVESWQADPDGHFDHPDDPRGARAATVPGFRGFGRADTDAEGWYALHTVRPGPLPTPDGETEAPHLNLSVFGRGLLHRLVTRIYFPDEPANAADPVLRTVDPGRRDTLVARPAADGYRFDIRLQGEHETVFFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGI1</accession>
    <name>F4FGI1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske (2Fe-2S) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_26090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734967.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26090"/>
    <dbReference type="EnsemblBacteria" id="AEB46316">
        <property type="protein sequence ID" value="AEB46316"/>
        <property type="gene ID" value="VAB18032_26090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26090"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_4_11"/>
    <dbReference type="OMA" id="GVINCPC"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307712" evidence="5">
        <location>
            <begin position="42"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="65"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="158" mass="15556" checksum="6BA1EA331F4CCC8B" modified="2011-06-28" version="1">MTDDQVAGARPVRTRRALLAGAGAAGAAAMLAACGGGDDGAATTSPGPQVTNTGDAGGGGRQDSQSLARTSDIPVGGGAVLSAQGIVITQPSPGEFRGFDPKCPHQGCNVTTVEGGTINCVCHNSRFSIEDGSVQSGPSPAPLERKDVKVSGDQIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGS2</accession>
    <name>F4FGS2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02490"/>
    <dbReference type="EnsemblBacteria" id="AEB47582">
        <property type="protein sequence ID" value="AEB47582"/>
        <property type="gene ID" value="VAB18032_02490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02490"/>
    <dbReference type="eggNOG" id="COG0748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145410_0_0_11"/>
    <dbReference type="OMA" id="RNVWLCT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="15526" checksum="A84AF5D535D845D1" modified="2011-06-28" version="1">MSPHRRAEVITAPGAEAVERLDRERVVWLCTLRPDGSPHLTPVWFLYLDGEWWIGTAERNRKVRNIAADPRVSLALPDGDAPVVAEGVASIVRQPFPAAVVDGLRHRYDGWDVTVDGPDGRYVLLRVAVTRWLMAGRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH60</accession>
    <name>F4FH60_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732505.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13630"/>
    <dbReference type="EnsemblBacteria" id="AEB43838">
        <property type="protein sequence ID" value="AEB43838"/>
        <property type="gene ID" value="VAB18032_13630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13630"/>
    <dbReference type="eggNOG" id="ENOG5032RX9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324783_0_0_11"/>
    <dbReference type="OMA" id="CGGDEPP"/>
    <dbReference type="OrthoDB" id="1857201at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309337" evidence="2">
        <location>
            <begin position="32"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="177" mass="18417" checksum="AE829BB0A1295A06" modified="2011-06-28" version="1">MRHLTCVARLAVAATVLTVLAGCGGTEPAAAPPAPAQPSEAAAPTEATEAPEPSAAAPVDACALVSKEDAEKLAGTPLEDPLPSGETCWFTGPVSGPVAQVEVHVGDGAKKILDIDRDLKHEFETLSGIGDEAYLEEGMVFVNVSGVWVAIRLVRTDDMAKYDERLTELARTVAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHA0</accession>
    <name>F4FHA0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-glycerol:poly(Glycerophosphate) glycerophosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732545.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13830"/>
    <dbReference type="EnsemblBacteria" id="AEB43878">
        <property type="protein sequence ID" value="AEB43878"/>
        <property type="gene ID" value="VAB18032_13830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13830"/>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465163_0_0_11"/>
    <dbReference type="OMA" id="WTGHHAD"/>
    <dbReference type="OrthoDB" id="1159548at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="565" mass="60094" checksum="98C8446E1E052C33" modified="2011-06-28" version="1">MRGDLVRKLAARGLATGAAVLAFIVVALTGATTWGLALSVLALAATVWERRVRPGADSGAETTLIAAGVLVGYARQLDAGFDPALAGTALILLGLMVLTGPLRDAGHLELRAANLPVRTWVPQVTARLGDLVAALLAVLALAALAALPAVVALAASLLAGGAVGAVAVKLVQRRMRPASGGSPVTRELRRHQPEFLLYFSAPPGSEYQVTMWLPYLERIGRPFVVMLREPDALPVIAAATTAPVLYCPTLRNMDEVLVPSLRAAFYVNHGAKNSHCLRFTQLTHIQLHHGDSDKASSANPVSAIFDRIFVAGEAAIDRYARAGVDIPADKFVVVGRPQVEAIEVGTGPTGPRPNPTVLYTPTWTGHHADADYCSLGVAEGLLSRLLDRGATVILRPHPYTTQNPTSARQLARLHDLLAADRARTGRQHLFGAAASGLTLAESVNRADALISDVSGVVSDWLYSGKPYAVTDTGADGDRFLERFPLAASGYVLRRDMVNLDEVLTQLLQTDPLAGVRWATRRRYLGDFPAETYAEAFLAAARRELDPSWSAPTPRTASDSPLSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F169</accession>
    <name>F4F169_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08025"/>
    <dbReference type="EnsemblBacteria" id="AEB42723">
        <property type="protein sequence ID" value="AEB42723"/>
        <property type="gene ID" value="VAB18032_08025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08025"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087306_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="28884" checksum="D710D836A11EB320" modified="2011-06-28" version="1">MSLLRRVIGVVLRRERQRQGLTLREVARAAGVSVPYLSEVERGRKEASSEVLAAVCRALGLYLSDLLEAVRDDLRRVERRMPSTPLGTAPLGSQPPPGRHAGGSVISSTRSASGGTPSPVARLGAVGSHASSGWLNATGGLAGSSSGLAGTSGGLAGTVGNELAGLPFGGFAPVGGVSGGLRITVFTDRLDTEADQHGRVVARGALRRPATVTRPSGSALRRARRMRSAALTVRLLGTPFRSDSRPRNTSRRGGRPAGHLVPGVLTPLLRSSRDLAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F177</accession>
    <name>F4F177_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tex-like protein protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732580.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14005"/>
    <dbReference type="EnsemblBacteria" id="AEB43913">
        <property type="protein sequence ID" value="AEB43913"/>
        <property type="gene ID" value="VAB18032_14005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14005"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_11"/>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="655"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="799" mass="86056" checksum="12DFDF8DA1420CEE" modified="2011-06-28" version="1">MTLSVHQRIAGELGVAEHQVRAAVELLDGGATVPFIARYRKEATGLLDDTQLRTLEERLRYLRELDERRAAVLESIRSQGKLDEALEAQIMAADSKSRLEDIYLPYKPKRRTRAQIAREAGLEPLADTLLGNPTQDPKTVAAGFVDADKGVADAAAALDGARAILIERFAEDADLIGTLREQMWSRGRLVSRVREGQETVGAKFADYFDFAEPYPKLPSHRILAMFRGEKEGVLDLTMDPEADGDADAVVTGPTRYEAAIAGRFGVTDQRRPADKWLTDTVRWAWRTRILIHLGADLRMRLWQAAEEEAVRVFATNLRDLLLAAPAGARPTMGLDPGLRTGVKVAVVDATGKVVATDTIYPHEPRRQWDASLHTLATLAAAHGVELIAIGNGTASRETDKLAADLIKRHPELKLTKLVVSEAGASVYSASAYAAQELPGLDVSLRGAVSIARRLQDPLAELVKIDPRSIGVGQYQHDLSEVKLSRSLDAVVEDCVNAVGVDVNTASAPLLTRVSGIGAGLAENIVLHRDANGPFRTRAELKKVSRLGPKAFEQCAGFLRIPGGDDPLDSSSVHPEAYPVVRRILSSTGQDLRSIIGRSAILRGLRATDFVDDTFGLPTVTDILAELEKPGRDPRPEFKTATFAEGVEKISDLTPGMVLEGVVTNVAAFGAFVDVGVHQDGLVHVSAMSRTFVKDPHEVVKSGDVVRVKVLDVDVPRKRISLTLRLDEDSAAGRGGADGRRERGDDRGGRRGDTGRGDRGSSGVRGGQGGRGGQPRQGRGTTPAPANSAIADALRRAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1E9</accession>
    <name>F4F1E9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA topoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_14365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14365"/>
    <dbReference type="EnsemblBacteria" id="AEB43985">
        <property type="protein sequence ID" value="AEB43985"/>
        <property type="gene ID" value="VAB18032_14365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14365"/>
    <dbReference type="eggNOG" id="COG3569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046978_1_1_11"/>
    <dbReference type="OMA" id="QYRYHPR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.66.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035447">
        <property type="entry name" value="DNA_topo_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55869">
        <property type="entry name" value="SSF55869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topoisom_I" evidence="6">
        <location>
            <begin position="85"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="37185" checksum="E0FAC63C37A2A7E5" modified="2011-06-28" version="1">MRTVRLRRSDPGRPGYGRRRRGQGWSYLGPGGEPVRDPDELARLRALVIPPAWRDVWISPYPNGHIQAIGIDAAGRKQYLYHPVWRQRQDQAKFDHVLEVARRLPVLRERVGHDLSGRGLRRERVLATVTRLLDMGTFRVGSDQYAAGDEPTFGVATLRAEHTRLRQGCVVFEFPAKGGVEQVRLVSDPELCQVLANLRRRRRAAQRLFGYWDGRDWRDVRADEVNDYLREASGGEMTAKDFRTWHATVRAATQLAALGTLRSVTARRRAVAGVMREVAELLGNTPTVARTSYVDPRVVDLFHDGVLAPVDGDASREQAERAVLTLLEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1J8</accession>
    <name>F4F1J8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NMT1/THI5 like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733881.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20635"/>
    <dbReference type="EnsemblBacteria" id="AEB45227">
        <property type="protein sequence ID" value="AEB45227"/>
        <property type="gene ID" value="VAB18032_20635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20635"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775872_0_0_11"/>
    <dbReference type="OMA" id="EVDAWIC"/>
    <dbReference type="OrthoDB" id="1918800at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="1">
        <location>
            <begin position="70"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="357" mass="38146" checksum="708A8F0E8E857719" modified="2011-06-28" version="1">MKNDRSIGAPVSRRSFLRLGATAGLLLPSAGGMTLLLSGCGSDDNKVNADGSISGTYMAASSLTLSYVETMVAKERGYFAEYGLDMEIKGGQGTATAIQAVLGGSADLTRANGINAVIAVANEQAPLVSIASLRQKSQFEVVSMPDKAIRNPAQLAGRTCGIVSTGGATENLLDVMLINAGVDPKTVKRPVTGVGTAAYELARKGEVDAWICVNTDRATIQKDIGEVVFFSTDEFAPMPSDSYNTSLQMIESDSEMPVKFLAGVLKAIEYASKEENWDQVIEDLRKYNPEANPAQARAELPLLVESWLAAGPDKVLQMNEQTWLSGQESLIKAGLVKSAAPIEKLIYKDYLDRARNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1N0</accession>
    <name>F4F1N0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein MerR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733913.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20795"/>
    <dbReference type="EnsemblBacteria" id="AEB45259">
        <property type="protein sequence ID" value="AEB45259"/>
        <property type="gene ID" value="VAB18032_20795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20795"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092079_0_0_11"/>
    <dbReference type="OMA" id="IAVGVVW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="20452" checksum="AC7B470C36FEBAE8" modified="2011-06-28" version="1">MHEPRDSDPVTGLDESGGTPGSATDGDGAVGYRGVTACHAVGISYRQLDYWARTALVVPSVRDASGSGTQRLYSFRDLVVLKVVKRLLDAGVSLQNIRKAIEALRSRGVADLAGITLISDGTTVYECRSPEEVVDLLQGGQGVFGIAIGGAFKEIQGSLSHLPAEPAGVVAEPDEPQEPAVGDELAARRARRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1R5</accession>
    <name>F4F1R5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27086"/>
    <dbReference type="EnsemblBacteria" id="AEB46490">
        <property type="protein sequence ID" value="AEB46490"/>
        <property type="gene ID" value="VAB18032_27086"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27086"/>
    <dbReference type="eggNOG" id="COG0380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_7_1_11"/>
    <dbReference type="OMA" id="VGEPAIH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="482" mass="53589" checksum="6B6B72BD77F0428E" modified="2011-06-28" version="1">MAVTPLLIGMPEMRQSSLVVVANRLPINDNVALDGACEWRRSPGGLVSALHPLLRHTPATWVGWAGGTGPAPTLPDVDGVRMHTVPLSSEDLRDHYEGFANATLWPIYHDAVEQPEHHRRWWDAYQRVNQRFAEATAQVAEKGAVVWVQDYHLQLVPGLLRALRPDLRIGFFLHVPFPPPELFMQLPRRAELLHGMLGADLVGFQRAQAAHNFAQLVTKVLGLPATDRRIAVEDRIVRIGAFPVSIDTAEMAALAGRPEVVDRARRLRHDLGSPDQVILSVDRMDYTKGIEQRLKAYSELLEGGHVKVRDTVLVQVAVPSRERVGQYQILRDRVEREVGRINGEFGRVGEPAIHYLTQPFDRTELAALYRIADVMAVTPLRDGMNLVAKEYVAARVDDAGALLLSEFAGAAAELSQAYLVNPHDLEGLKQGLLAALRAEPADVRARMQAMRAHLREHDIRAWARSYLSTLDQTGLLLTRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F246</accession>
    <name>F4F246_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013283866.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08085"/>
    <dbReference type="EnsemblBacteria" id="AEB42735">
        <property type="protein sequence ID" value="AEB42735"/>
        <property type="gene ID" value="VAB18032_08085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08085"/>
    <dbReference type="eggNOG" id="ENOG5032Y97">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188374_1_0_11"/>
    <dbReference type="OMA" id="IVMRVPV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021465">
        <property type="entry name" value="DUF3117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11314">
        <property type="entry name" value="DUF3117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="5593" checksum="9A89DB18EEE97662" modified="2011-06-28" version="1">MAAMKPRTGDGPLEVTKEGRGIVMRVPLEGGGRLVVEMTPDEATALGDALKAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F257</accession>
    <name>F4F257_MICM1</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731418.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08140"/>
    <dbReference type="EnsemblBacteria" id="AEB42746">
        <property type="protein sequence ID" value="AEB42746"/>
        <property type="gene ID" value="VAB18032_08140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08140"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_0_2_11"/>
    <dbReference type="OMA" id="GHTSFNW"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313506" evidence="2">
        <location>
            <begin position="36"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="160"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="32709" checksum="7E191138DBDC879E" modified="2011-06-28" version="1">MPLEPHRPPRELLTTGALALAVVAVSSSAPLIAFAAAPALAVAFWRNMIAVGVLSPFAVLRRRAEFRSLVTGAGRREGMFCVLSGVALAAHFATWMPSAKLTSVAAATALVATQPVWQGLIARAQGRRLPAGVWAGIGVAVVGAVLATGADFTVSAQAFTGDLLAVVGGLFAAIYTALGERARVTVSTATYTTICYGVCALILLVICLVAGVPLGGFDTGTWLAVLALVAGAQLLGHSMFSYALRRVSATTVSVLILLEAPGAALLGWAWLGQLPDPVTLPGLALLLVGVAVVVLSSARTARRATRVSTAVPADAAPIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2D8</accession>
    <name>F4F2D8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear export factor GLE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14490"/>
    <dbReference type="EnsemblBacteria" id="AEB44010">
        <property type="protein sequence ID" value="AEB44010"/>
        <property type="gene ID" value="VAB18032_14490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14490"/>
    <dbReference type="eggNOG" id="COG4549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873813_0_0_11"/>
    <dbReference type="OMA" id="TRIELTM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312628" evidence="3">
        <location>
            <begin position="33"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="35"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="29522" checksum="CB95EA9610A55709" modified="2011-06-28" version="1">MTRGGSRRRRGGLVAALATAGVLLWPATTAWADGVTFTPTEAQQGNSVKLEFLVPDERPGVRTERIEIRMPAETPVAEVYPLSVQGWAPAITTRKLDVPVAGMHGPATDVVTAALTWTRGTGEAGTGPARLVFSMAPLPQTDQVRFELTQTYADGLQVHWGDRPGQRPLPALILTPGDPAYPGAAHGGHGAAPGGAVPGAPAPAAATPDEGPNANSLLAAGLVAGLGGGAVVGWLISRRRRADTEEIDRSVLDEEPAAENGPTAVADAEPTQRRDDRVARAGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2H2</accession>
    <name>F4F2H2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dnaE</name>
        <name evidence="8" type="ordered locus">VAB18032_14660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732711.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14660"/>
    <dbReference type="EnsemblBacteria" id="AEB44044">
        <property type="protein sequence ID" value="AEB44044"/>
        <property type="gene ID" value="VAB18032_14660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14660"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_0_0_11"/>
    <dbReference type="OMA" id="NECRRMG"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1177" mass="129526" checksum="2013F84243EA431E" modified="2011-06-28" version="1">MGDSFAHLHVHTEYSMLDGAARLKDLFAEVKRQGMPAVAMTDHGNMHGANDFYKQAMAAGVTPVLGIEAYVAPESRFHKKRVRWGRPEQKSDDVSGSGGYTHMTIWARNRVGLHNLFKLTSKAYTEGYFVKWPRMDAELLAEHADGLMATTGCPSGEVQTRLRLGHDAQALEAAAKYQDIFGKENYFLELMDHGLDIEKQVRDGLLEIGRKLNIPPVVTNDSHYTHEAQSEAHDVLLCVQTGSNVADPNRFKFGGSGYYIKSADEMRGVDNSDVWLEGCRNTLLVAEKVDPTGMFEFHNLMPRFPVPEGETEESWFRKETFAGLARRFPNGIPEGHVVQAEYELGVIIQMGFPSYFLVVADFIQWAKNQGIAVGPGRGSAAGSLVAYALGITDLDPIPHGLIFERFLNPERVSMPDVDIDFDERRRGEVIKYVTDKWGEDKVAQIATFGTIKAKAAIKDSARVLGYPYAVGDRITKAMPPAVMGKDIPLEGIFDPKHPRYAEAGEIRGMYESEADVKKVIDTARGIEGLIRQTGVHAAGVIMSAEPIIDHIPLMRRDSDGVIITQFDYPTCESLGLLKMDFLGLRNLTIIDDAVKNIQLNHGKELDLLGLPLDDKGAYELLARGDTLGVFQLDGGPMRSLLRMMKPDNFEDISAVLALYRPGPMGVDSHTNYALRKNGLQEITPIHPELEEPLKEILAPTYGLIVYQEQVQRAAQILAGYTLGQADLLRRAMGKKKKEILDKEFIPFRDGCRERGYSDDAIQKVWDVLVPFAGYAFNKAHSAAYGLVSYWTAYLKAHYPAEYMAALLTSVGDDKDKMALYLSECRRMGIQVLPPDVNTSAGPFTPVGKEIRFGLGAIRNVGANVVTSIMRCRQEKGEYADFYDFLSKVDAVVCNKKTIESLIKAGAFDSMGHSRKGLLTVHADAIDAYADVKRKEAVGQYDLFGAGFGEAEVATNTQVMPTIGDGEWDKRDKLAFEREMLGLYVSDHPLFGLEHILGASADCTISALSEEGTVPDGAVVTLAGILSGVQRRVTKQGRAWASATLEDLAGGVETLFFPNTYEVIGQYIAEDAIVVVKGRVDRRDDIPRIMAMDMSLPDVSTSTTNKAVTLTIPVTRCTPPLVERLKETLVLHPGDAEVHVKLLNGSRTTLLRLGPVRVAATTALMADLKSVLGPANVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2L5</accession>
    <name>F4F2L5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Formate dehydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_20900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 4 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733934.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20900"/>
    <dbReference type="EnsemblBacteria" id="AEB45280">
        <property type="protein sequence ID" value="AEB45280"/>
        <property type="gene ID" value="VAB18032_20900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20900"/>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_0_2_11"/>
    <dbReference type="OMA" id="KACQSAC"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015944">
        <property type="term" value="P:formate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014603">
        <property type="entry name" value="Formate_DH_Fe-S_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036298">
        <property type="entry name" value="FDH_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036298-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="32598" checksum="A399D13F7F9170FA" modified="2011-06-28" version="1">MVDTDDRSTPRDPATGAGWVDAPPRMGFFTDTSVCIGCKACEVACKEWNGVPTSGLDLLGMSYDNTGALTANSWRHVAFIEQPRPAAAPEQTDTTTQFLGMPQSGPPGRTGTAEGRSDFRWLMMSDVCKHCTRAGCLDVCPTGALFRTEFGTVVVQEDICNGCGYCVSACPYGVIDRRVDDGRVWKCTLCYDRIGAGLTPACAQACPTESIQYGPLDELRERAAARVATLHERGVPEARLYGHDPSDGVGGDGAFFLLLDEPEVYGLPPDPQVPTHDLPKMWKRAGVAALAMAAGAVVAFLGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Z5</accession>
    <name>F4F2Z5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735256.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46606">
        <property type="protein sequence ID" value="AEB46606"/>
        <property type="gene ID" value="VAB18032_27666"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27666"/>
    <dbReference type="eggNOG" id="ENOG5031UIE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2789261_0_0_11"/>
    <dbReference type="OMA" id="PLTHHHV"/>
    <dbReference type="OrthoDB" id="2033830at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="68" mass="7341" checksum="D798E0EECF691A05" modified="2011-06-28" version="1">MAATVEIPLVGGSADGQLVTVELDPNDRPPLTHHHVGSGGLAEADIYELESIDAQAQQWCYRWRGQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F318</accession>
    <name>F4F318_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-Nucleotidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03575"/>
    <dbReference type="EnsemblBacteria" id="AEB47797">
        <property type="protein sequence ID" value="AEB47797"/>
        <property type="gene ID" value="VAB18032_03575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03575"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003555_0_0_11"/>
    <dbReference type="OMA" id="IWNINSV"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1369" mass="141858" checksum="EF6C4F5BB42DEA30" modified="2011-06-28" version="1">MGSGTTAFAAPASATPFISEIHYDNAGTDVGEAIEIEAPVGFDLSGWQIVLYNGGNGAAYSTRTLTGSVPESGVVVAEYPVNGIQNGDPDGVALVSPSNSVSEFITYGGTFTAVGGPANGLAGTDIGVKESSSTPVGHSLQKIDGAWKAPAPNSFGVRNTAGGGDPGPGDPPVGCDVAVSHTIAQVQGSGTATPVAGSRVTVEGVVTADHRTGGYNGVYVQTAGSGGERTVAAGTASDGIFVYLTTNTANHPAVTIGDRVRVSGTASEFNGLTQLSIATRGDVQVCEQGAPLPAPVPVELPLTDDARESVESMLVAPVGAYAVSEVYNTNRYGEVALAAGDKPALTPTDVARPGSAEARQIAADNKARRILLDDGRTTNLSTAGLLPPYLSKDSPLRVGDSVEAFGPSVLSYAFEEWRLQPTRPVDADTRPGDRTTFKVTNPRTAAPVNVGGDLRVASFNVLNYFVHFGGDARGAANEAALAKQEAKIVSAISALDADVVALEEIENSVRFSSSDPQRALKRLVAALNTADGAGTWDYVRTPTELPGAAQQDFITTAIIFKPAKAQPKGASRSVNDESVWFNAREPIAQTFTAGPLDFVVVANHFKSKSGAGSGDNADSGDGQGGWNGDRVRQATALATFVDQVKADSDTDNVLLLGDFNAYTQEDPMQVLYGKDYRNLNNTGKTSYVFNGESGSLDHALASPSLADRVTGVDVWQINAVESYAFQYDGLAAFYAPDPYRASDHNPLVVGINTGASPVDLQLLSINDFHGRLESPATVGGQPAGGAAQLAGLVNQLRTQNPNTAFVSAGDNIGASTFISAIDDDNPTIDALNAAGLIASAVGNHEFDKGMTDLTGRVTDRADFPLLGANVYRDDTRALPAYSVSSIGGVRVGFVGVVTEQTGSLVSPDGIAGITFRDPVVEANLVAGQLKDGNPANGEADVVVLLAHEGAATENIDSAEALANDPVFGKFTRVDATIDAIFSGHTHQPYAFEVPVPGTDKLRPVVQAEDYGKRLGKVTLTFDPESNSVTAADASLVDVVGAPQDPAVADIVAAAKVRAQELGQRQLGEITADIRRAYTDGNEDRGKESALGNFIADVQLAGTSAPGRGGAQIAFMNPGGLRADLLYRTDGTVTYADAFSVQPFSNDVVTKSYTGAEIKQTLEQQWQPTGASRPVLWLGVSKGFSYTYDPQAERGSRITSMQLNGVPIDPTATYRVTVNSFLASGGDNFTALGGGTNPATTGDNDLTMLVNYLAANSPVTADTTPRSTIGQGGPAWEVEVQARTQCVGSNAYVSVSARNADDVALSIELVTPYGSRVVADVAPGKTAYQAFNSRAKTVAAGTSTVKITGTVNGQPATIQVESAYAAITCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3B2</accession>
    <name>F4F3B2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_08590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08590"/>
    <dbReference type="EnsemblBacteria" id="AEB42836">
        <property type="protein sequence ID" value="AEB42836"/>
        <property type="gene ID" value="VAB18032_08590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08590"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="OMA" id="WYAYAMI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="33755" checksum="E236DE4EAE4B242D" modified="2011-06-28" version="1">MVLPVVIVLAVLIFYPLFRGVWLSFTNLTEANQVAEICTRSITGGEVCTDNPNKWEFVGLDNYVRVLTGEVGEFWQWTGVTLIWTFVCVACHFGLGLGLANMLNRPMRARGFYRVVLVLPWAVPAFVSAFAWKFIFNERFGLANALLTALGIDPVSWFADRWTALLTAIVTNVWLGVPFMMVALLGGMQTIPSELYEAAEIDGASAWQRFKNITLPGLRPVSMTVVLLGTIWTFNMFPIIFLVTEGQPAGQSEILVTGAYRAAFEGIRNYSLASTYGVLILSILLVFSVFYRRVLRKQGEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3G8</accession>
    <name>F4F3G8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombination factor protein RarA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_14820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732743.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14820"/>
    <dbReference type="EnsemblBacteria" id="AEB44076">
        <property type="protein sequence ID" value="AEB44076"/>
        <property type="gene ID" value="VAB18032_14820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14820"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_1_0_11"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="977094at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="70"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="503" mass="52568" checksum="1494D589A47BC6ED" modified="2011-06-28" version="1">MESETLFTLGEPAAAASAVAGSSGVGGFTPVGPDAPLPVRMRPATLDELVGQDHLLAPGAPLRQLVTGDAPMSVILWGPPGSGKTTIAHLVAAATDRRFVAMSALSAGVKDVRAVIDTARRQRRSGGPPTVLFIDEVHRFSKTQQDSLLAAVEDRTVTLLAATTENPYFSVISPLLSRCVLLTLQPLDDAAVRGLLRRAMTDERGLAGALTLDSEAEDHLVRLAGGDVRKALTALEAAAGSATALGTGRIDLATAERAVDTAAVRYDRAGDAHYDVTSAFIKSMRGSDVDAALHWLARMLVAGEDARFIARRLVIFASEDVGMADPSALSVATAAAHAVEYVGLPEVQLNLAQAVIHLATAPKSNSATTAIGAAIADVRAGRGGAVPRSLRDAHYAGARGLGHGTGYRYPHDDQRGVVRQQYVPDDLVGTDYYQPSQHGAERSVATRLPLLRRIVRGLAAPTTTPPVSGRAPARPGAEEPQLTTADAEVTDEVGDRADGKGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3K3</accession>
    <name>F4F3K3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ordered locus">VAB18032_14995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732778.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14995"/>
    <dbReference type="EnsemblBacteria" id="AEB44111">
        <property type="protein sequence ID" value="AEB44111"/>
        <property type="gene ID" value="VAB18032_14995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14995"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_2_1_11"/>
    <dbReference type="OMA" id="CFNTGMT"/>
    <dbReference type="OrthoDB" id="662268at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="387" mass="41659" checksum="3065FA87D08C73CB" modified="2011-06-28" version="1">MSRRRPAILVLEDGRTFHGEAYGSVGETFGEAVFNTGMTGYQETLTDPSYHRQVVVQTVPHVGNTGVNAEDDESRRIWVAGYVVRDPARISSNWRATGGLEDRLATEGIVGISGVDTRALTRHLRERGAMRVGISSIDDDPRALLARVRQSPQMVGADLSAEVTTTAPYVVAAEGEHRFTVAALDLGIKRNVPRRLAARGVTTHVLPVTATIDDLLATGADAIFFSPGPGDPATADGPVKLAREVLRRKVPLFGICFGSQILGRALGFGTYKLDYGHRGINQPVLDRMTGKVEVTSHNHGFAVQVPGVTPGATVPDEVIETEFGGVQVSHVCLNDNVVEGLRALDVPAFTVQYHPEAASGPHDADYLFDRFAELIEGRTHNEGHSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3M0</accession>
    <name>F4F3M0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum_form domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732793.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15080"/>
    <dbReference type="EnsemblBacteria" id="AEB44128">
        <property type="protein sequence ID" value="AEB44128"/>
        <property type="gene ID" value="VAB18032_15080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15080"/>
    <dbReference type="eggNOG" id="ENOG5031HT4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080960_0_0_11"/>
    <dbReference type="OMA" id="TYETVDC"/>
    <dbReference type="OrthoDB" id="1953080at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026004">
        <property type="entry name" value="Septum_form"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13845">
        <property type="entry name" value="Septum_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312662" description="Septum_form domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Septum_form" evidence="2">
        <location>
            <begin position="50"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="32042" checksum="B858F83DE8B620B2" modified="2011-06-28" version="1">MRRWFAALALASAAAIALSGCVRQGATDGDLTDDWPALRVPTMFVPATDACLPRVTAIVQASTYETVDCARNHLAEAVHVGAFTGRAANGPRPEPGSAALRTARAECDQRARLVLGGDWHVARLTLNIALPSVSAWNGGARWFRCDLSETDSIDNTRPVNRTGSLRGALIGDSPLVHRCFDPKLIGNSLNYMAPVLCTEPHGAEFVGVYTEQDMTWEEFTNSAGQAHRRCMSLIAEYADVPNNSDLPYRAGSIFYPPSQREWEEGDRGVRCLLWSDDRKLTGSMRGVGPQGLPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3T2</accession>
    <name>F4F3T2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21415"/>
    <dbReference type="EnsemblBacteria" id="AEB45383">
        <property type="protein sequence ID" value="AEB45383"/>
        <property type="gene ID" value="VAB18032_21415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21415"/>
    <dbReference type="eggNOG" id="COG5516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087298_3_0_11"/>
    <dbReference type="OMA" id="WISMETP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="215" mass="23608" checksum="5D1747574F00CEE9" modified="2011-06-28" version="1">MGQLVKWISMETPEDVTRMRLVGGNLALDFVNTRSGPPAGAPDDDTLTSYSDLVAWGVYAGALTPAQAAALRRGSRDDPGGAEAAFGQALRIRDDLDEAFRALATGRDPSASVLARLRDDEAEALRHARLERDLTYGWTWHADGTLARPLRPVVHAAVGLLTTGQLDRIKGCGGCRFLFYDESKNRSRRWCSMDDCGTAEKIRRYVTARRSRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4F2</accession>
    <name>F4F4F2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_08960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731581.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08960"/>
    <dbReference type="EnsemblBacteria" id="AEB42910">
        <property type="protein sequence ID" value="AEB42910"/>
        <property type="gene ID" value="VAB18032_08960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08960"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_0_1_11"/>
    <dbReference type="OMA" id="ANTRFHA"/>
    <dbReference type="OrthoDB" id="1813832at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="19599" checksum="E209ADF981A2EFF6" modified="2011-06-28" version="1">MTGEPGSRQTRRGLIHSLRDRFGHLVREMSKFATVGGVAFLIDFALFNYLIGPARVEQITAKTIATVIAATFAFLGNRFWTWRHRKRSHPAREYALFFFFNAVGLGIAVACLAISRYGLGGIWPEVFQTRLADNIASFVVGTGLGTLFRFWSYRRFVFVDTGTPVAAEVDRDRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4J3</accession>
    <name>F4F4J3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731622.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09165"/>
    <dbReference type="EnsemblBacteria" id="AEB42951">
        <property type="protein sequence ID" value="AEB42951"/>
        <property type="gene ID" value="VAB18032_09165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09165"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028527_0_0_11"/>
    <dbReference type="OMA" id="VHEAMPG"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="539" mass="59368" checksum="46394D61679A208F" modified="2011-06-28" version="1">MERFEVVAERIVEALLVSRPGLAAVAGDHRFDDRLPDLSADAVAGDRAMLVDAASVLCEIDADSLDVEERVDHALLSTLVDRQLFELTEIREHEWNPLVHNPGPLLNGLFVRPYAPAEQRLAALVGRLTAVPDALATARATLRDMPRVHAETAVGQFTGTAALIRDEVPALLEQAPALLDQVEPAATGAIAALEEFVAWLRAGLAADTGPGRDPRLGRRRWEARLWYALDTELSAAEIQRRAWANLDRVGEEIRAAAVELVGGPADDETVRRALDLLAAEHPDDHTIVDLASITMDEASDFVRAHDLVTVPDDRCVIQVMPEFARGVAVAYCDAPGALETAEVPTFYCIAPTPADWPAHRVDSFYREYNDHMIRNLTVHEAMPGHFLQLAHARRHVGSTRVRALTRSGPFVEGWAVYAEQVMAEHGFGGLPVRLQQLKMQLRMTLNALLDQLVHAEELPEAEAMALLTGRGFQEEGEAAGKWRRALLTSTQLSTYFVGYSEVAEIAADRPAEVSIRDWHDAMLAHNCPPPRHLRTLLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F583</accession>
    <name>F4F583_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">VAB18032_28471</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735415.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28471"/>
    <dbReference type="MEROPS" id="M01.012"/>
    <dbReference type="EnsemblBacteria" id="AEB46765">
        <property type="protein sequence ID" value="AEB46765"/>
        <property type="gene ID" value="VAB18032_28471"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28471"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007335_1_1_11"/>
    <dbReference type="OMA" id="EGMHRFT"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="85"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="223"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="518"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB46765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="837" mass="91008" checksum="F526CF12734B9608" modified="2011-06-28" version="1">MPSLSRAESTARGASIAVESYHVDLDLTGGGERFRSQVTIRFTATGTETFAEVKPAKLLAVRLNGVDLDPAGLDDNRLALTGLAEENTLTVEAEMAYTNTGEGLHRFVDPADGETYLYAMSFLDDVQRIFAAFDQPDLKAPVTLSVTAPPHWTVAANAELAAQPGPGRWEFAPTLPISTYLFSLIAGPWHVRRDEHDGVPLGIYCRRSLAEHLDADAEEIFTVTRQCLDRFHQLFDERYPFGKYDQAFVPEFNAGAMENPGLVTFRDDYVFRSAVTDTQRELRATTIAHEMAHMWFGNLVTMRWWDDLWLNESFAEYLGTRVTAEATRFDQAWTTFAMRRKAWGYAADQRPSTHPVAPDELSDAAEALLNFDGISYAKGASVLRQLVAWLGDEPFLAGLNDHFSRHRFGNATLADLLASLGSASGRDLAGWAQAWLRAAQVNTLRAEVALDADGRYREVAVLQTAPPAHPVLRPHRIGVGRYAVDGSADRFEVDLDPSTDGGRTVLDRLTGEPASAVLLPNDGDLTFAKIRLDSASVDAVPLLLPRLADPLARALLWGEALDAATDGERPVMAVVELIGQALPTETEVIITEDVLALSRSLVDRYLDPSMRPTALAVIDEACRRMLDTAPAGGSMQLAAARGRIAATIDAALLTGWLGGRGVPDGLAIDTELRWKILGRLVVLGAAGAAEIEAEATADRSAAGAEHAARYRAALPDPAAKQAAWQMIVADTTVSNRLIEATAAGFWQPEQAELTAEYVPRYFADMPAMARLRTPWVADEVAKLAFPRYAVAQPTREAAAALLSRDDLTPGLRRVITDADDDLRRALVARTAVAATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5L3</accession>
    <name>F4F5L3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09635"/>
    <dbReference type="EnsemblBacteria" id="AEB43045">
        <property type="protein sequence ID" value="AEB43045"/>
        <property type="gene ID" value="VAB18032_09635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09635"/>
    <dbReference type="eggNOG" id="ENOG5031Y01">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167531_0_0_11"/>
    <dbReference type="OMA" id="GEIWLDP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12134" checksum="4455A3C00422882A" modified="2011-06-28" version="1">MAGQLWLDPSRARRGGADLTRAGEAVAGRHAEAGAAIAAASSRRPWGRDDIGAAFERQYRGYEEMALRVWAGVGRRLAELGGDVVRSVETNQQTDAASGARFDRISDPRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5U6</accession>
    <name>F4F5U6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22025"/>
    <dbReference type="EnsemblBacteria" id="AEB45505">
        <property type="protein sequence ID" value="AEB45505"/>
        <property type="gene ID" value="VAB18032_22025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22025"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_100_0_11"/>
    <dbReference type="OMA" id="MYEPSIC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="181"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="292" mass="31766" checksum="7453728D141EBED2" modified="2011-06-28" version="1">MLARHARPDGSTAIDGVLIGRADQAHLPSASMSGTVLALIAQGAKTLALGDRVYEYRAGQYLIASVDLPVTGHYTEASRERPALGFGLVLEPAAIAELLLDTPPGSLPRTHGAPSALAVSDAPVELVDAAVRMLRLLETPRDIPVLAPMIKREILWRLVTGEQGETVRQVGLADSNIAHVSRAVRWIRDNYREAFRVEEVAQLSGMSLSAFYRNFQAVTAMSPIQFQKQIRLQQARLLLATHPDDVTGVGHAVGYDSPSQFSREYRRHFGAPPSQDATRLRRTALTPVPAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5X2</accession>
    <name>F4F5X2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbamoyl-phosphate synthase, large subunit, CarB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734184.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22155"/>
    <dbReference type="EnsemblBacteria" id="AEB45531">
        <property type="protein sequence ID" value="AEB45531"/>
        <property type="gene ID" value="VAB18032_22155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22155"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787420_0_0_11"/>
    <dbReference type="OrthoDB" id="1571319at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="66"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="352" mass="38354" checksum="72A44A4106C20946" modified="2011-06-28" version="1">MSQVSVYLVGVQSLASWFTHFVQWRPGDRHLHLGEGPVDTEALQRSFQGLDVATAVFLTSHDTLLRDRELAAGLRLAGHRVIVQSANAASLGLDKVAMKRFFDRHGIPTAPWRYQDEGTLDGAGDDLLVVKGRNSTQSIGIRMATEVTSSPQYFTERYADGVEYSVVAHRTAGRTITLPPVWKGPTSPMLVPPWRRLRLCPAPGLTPALDTWLRDTTETIARAADIDGYLEVEFLVRADGTGLVLEINPRICGTLRIAALAAEVPVFSLHHLTSSAALPALRYAAEVPYTGASFNDPAQQVYATSRLTVAAPDPTTVITALRRHAGDRALLYDPWTTGNAPTLLGAREETPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F617</accession>
    <name>F4F617_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18655</name>
        <name evidence="3" type="ordered locus">VAB18032_22380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733488.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18655"/>
    <dbReference type="EnsemblBacteria" id="AEB44833">
        <property type="protein sequence ID" value="AEB44833"/>
        <property type="gene ID" value="VAB18032_18655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45576">
        <property type="protein sequence ID" value="AEB45576"/>
        <property type="gene ID" value="VAB18032_22380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18655"/>
    <dbReference type="KEGG" id="vma:VAB18032_22380"/>
    <dbReference type="eggNOG" id="COG1785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352234_0_0_11"/>
    <dbReference type="OrthoDB" id="585847at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007656805" evidence="1">
        <location>
            <begin position="32"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="210" mass="21487" checksum="14D386B10CF355B8" modified="2011-06-28" version="1">MNTWSRKRLLAAGASGALLAGVVAVGSPAFAEPGDEAGVEVTVEIEEIREPGVLAMTVAADSVLLSEDGSTLLVRQFTGTLPTVTVTDTRTADEVPAGAAWAVLGSATDFVGDADQAPIGAGHLGWKPKLIDGGDTGLVSEGEEVVTVLDEPTQPGNNVGLVDQELLVSTFDSGAVTPGEYTVDADLFLRTPADVEAGAYTSTLTLSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6A0</accession>
    <name>F4F6A0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gln_amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731717.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09640"/>
    <dbReference type="EnsemblBacteria" id="AEB43046">
        <property type="protein sequence ID" value="AEB43046"/>
        <property type="gene ID" value="VAB18032_09640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09640"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004831_0_0_11"/>
    <dbReference type="OMA" id="CDIEGAK"/>
    <dbReference type="OrthoDB" id="261057at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028908">
        <property type="entry name" value="Tox-PL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15644">
        <property type="entry name" value="Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln_amidase" evidence="2">
        <location>
            <begin position="857"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1059" mass="108847" checksum="B3DE942883AE63CA" modified="2011-06-28" version="1">MTLLPSPIPHPLDYSPWDLPGWIYEALDWVIGVEWPEGDERAVWDLADQWYAVAASLAGPQADASTAAAEVHQGYGGVGAVAAAFGGAWRRVADGEDAPLPVLLAVSHDLGRVVEECGCDIEGAKLEVWIELGILVVELLALAVAAVLTAGAASPAAAGVIAATRFIVQQIFRRLLAQLARKSLKQGLKEVGERAAKQVTTTGARGLARHAAREGLTEAAQEAGVNLATQVYQQSTGRRHELDVTDLSTNAIGGLAGGAAASLAGLGRHATGGGARMAEHLGREMTGEVIADQAASLATGQGLTSLEDAARAAASGARGSATGQADRALQARLDGQLAALSGPALPSVLPGPAIPAPAAPELTLPLAGGASTQPTPVVESAQGAAIPAQRTSTEPPAVGPMGSTSPAAGPALPLPAADGGVDLEPPHGGGPVSLAGSALNETVHRPPDPGLTTESAPTPGSALTTELGSTPESTRPGREVPASAQSSVAAVGPASMAGLVDVSGPALSTVAPPSVVPGVATGPDMTAAGGVAGGLAPPSGAAHSSGAAHSSGAVHPGGPVHASGPVAAVGISGSSTATGSAAAGPVMDRVPGASTATRPEAGSPGGPPSRPEPSPAPPRSALVEALVPNAPTVNSPGRVTPPTAPPTRPDPEASRTADYEALERRRYQGYYESQRAGHEESRRSREVSRLRSQADEHYQRASDFTAYARQLHQAGHRDASANWQQAAKAETRAYGRCLDLADAVASGAVVPDVVAVDRPEDFHRINDDVGDLAVGAIDTGDRSALTGDDHPPPIDRSRRYGQPGGLRPPLALHQRDVEQQLPRDEAGNVVRTADPRAGDWFGLMNDGGPRADPTRGINCLDCTLSLYDTWVHGRPRVAAPRTFDAYQAGDVTRPLNGEQDGTGRVEDVTGGRFQRLCDGTARTPVELQRALDTGYRNLRDQLVLGGHGSFAFVVNHLERGGAHIWVALNQNGTVLYVDPQVGLVSDQPLYRYHGPAHPFNAVDADVLVLDGGARPMPLAGLRRGIYSQRPDLPRYPPAEEFEGYGDPYLNRVHLLGDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6H7</accession>
    <name>F4F6H7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10025"/>
    <dbReference type="EnsemblBacteria" id="AEB43123">
        <property type="protein sequence ID" value="AEB43123"/>
        <property type="gene ID" value="VAB18032_10025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10025"/>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2482431_0_0_11"/>
    <dbReference type="OrthoDB" id="2036047at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="87" mass="9989" checksum="B44CC29357A11FC9" modified="2011-06-28" version="1">MAMTVYRSRNALCGPLTPDGITELALPRTRLARRGYQVDEVDALLHRLAYELGERSRQLAEVRAENRRIKNALRIWQSAETARRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6J9</accession>
    <name>F4F6J9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartyl/asparaginyl beta-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732987.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16105"/>
    <dbReference type="EnsemblBacteria" id="AEB44327">
        <property type="protein sequence ID" value="AEB44327"/>
        <property type="gene ID" value="VAB18032_16105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16105"/>
    <dbReference type="eggNOG" id="COG3555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071783_0_1_11"/>
    <dbReference type="OMA" id="THEAWNY"/>
    <dbReference type="OrthoDB" id="1564693at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018193">
        <property type="term" value="P:peptidyl-amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asp_Arg_Hydrox" evidence="1">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="20545" checksum="EBB54B2B57820480" modified="2011-06-28" version="1">MFLDQRQFPFLADLRARWEAIRDECLALPQDSYQPWVQREMYGQGWSVYGLVAFGERIEEALAACPDTASALTTIPHLTTAGFSRMAPGTHITPHEGWVTTVYRAHLGLVVPQDCALRVGDETRQWSEGQTLVFDDTVTHEAWNYGSSDRIVLLFDFARPGCEDMPQDELPTTVADLVRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6K8</accession>
    <name>F4F6K8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16150"/>
    <dbReference type="EnsemblBacteria" id="AEB44336">
        <property type="protein sequence ID" value="AEB44336"/>
        <property type="gene ID" value="VAB18032_16150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16150"/>
    <dbReference type="eggNOG" id="ENOG5030HI3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_986292_0_0_11"/>
    <dbReference type="OMA" id="RWHPLGP"/>
    <dbReference type="OrthoDB" id="2080029at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="25917" checksum="7EFDD724E204FE54" modified="2011-06-28" version="1">MVFRVKRFNAGHMTEADQRYGTHEALGPHGVLLFFTSPAPTEPHGYRLHTAWRLFLSAPESDDLPRILGDLSRIAKTHITHANATGHRWHPLGPQRSMVNGGDMGIPADATYVGVGASTLDTDDGRWYQLARTLREPSATGHRRSAFDLKGHCYLLLTDDTAIHIDRNPHAPLHYDGIRSSKPLDADRSAHWHNPHANLTDQGDHHTREVWRHLTALHHTLTSYLTARPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6W2</accession>
    <name>F4F6W2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734289.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22685"/>
    <dbReference type="EnsemblBacteria" id="AEB45637">
        <property type="protein sequence ID" value="AEB45637"/>
        <property type="gene ID" value="VAB18032_22685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22685"/>
    <dbReference type="eggNOG" id="ENOG5031VK5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1873055_0_0_11"/>
    <dbReference type="OMA" id="HAPPGND"/>
    <dbReference type="OrthoDB" id="2057825at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="14463" checksum="752185A6FECBF81B" modified="2011-06-28" version="1">MAVPALTPRNTPPRSLPLREARTRLSQLVAMAELTDTVTVVTRDGDSRPVAAIVPADAARSAAQARADAGRLAEVTAGWSRRLEAQREQAGRRHAAELCAMRAALAEVWAALERRAAPGDAELARLRAGHADLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F723</accession>
    <name>F4F723_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29081"/>
    <dbReference type="EnsemblBacteria" id="AEB46887">
        <property type="protein sequence ID" value="AEB46887"/>
        <property type="gene ID" value="VAB18032_29081"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29081"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_24_2_11"/>
    <dbReference type="OMA" id="FLNWYNV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_7C" evidence="3">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="33752" checksum="E7A8027C2A5C1AC2" modified="2011-06-28" version="1">MPKCSVVISTYNRRELLRRTLDSLTRQTLPRTDFEVLVCDDGSSDGTGDMVVGYADRIDVHHLYQEDLGARVSAARNMGITAARGEVCVFLDDGVVAAPDCLRAHVEAHEAADGPLALIGYVWAYTPHHDVSAEDAARMEQILDRSDADELIAWLRADGRLPDFREEYYAKYGDDFGTEPAPWSIFWTCNVSAPTEMIREVGMFDQGFRGWGGEDCDLGYRLHRAGAYVALSRAAAAVHMPHPGASKSEEAYNYAYMADKYDTPITRLLHRYTSLEVNPFNINDVIKAEGLPSCAEYEAQAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F788</accession>
    <name>F4F788_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10140"/>
    <dbReference type="EnsemblBacteria" id="AEB43146">
        <property type="protein sequence ID" value="AEB43146"/>
        <property type="gene ID" value="VAB18032_10140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10140"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023673_0_0_11"/>
    <dbReference type="OMA" id="EAMHIGF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="276"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="548" mass="58938" checksum="C874E7B4550329C7" modified="2011-06-28" version="1">MVIAFRDALAQMFKARFPILYVESSEEQRVVAEVCAIAGDATAVRTPRAVWIWSLTTGLVAPDGTPRQGTTDPEAALDAALRVDQPSVLIFKDLHPALGADGRPGSPGLIRRLRDLVAAFKSGPVPRTLVLVSPVLHIPAELDKEVTIVDFPLPTEAEIRQVLDAMIAANAANGRIQMVLDDQGRERFAKAALGLTLHEAENAFARAMVNDGMLDAHDLEVVHEEKRQTVRKSGLLEFVEADVDLDDVGGLENLKRWLAKRDGSWLAEAAAYGLPAPRGVLITGVPGCGKSLTAKAIAAAWGLPLLRLDIGRVFAGLVGSSEQNMRTAIRTAEASAPCVLWIDEIEKGFAGGTGDSGTSTRVFGSFLTWMQEKKQSVFVIATANNIEALPPELLRKGRFDEIFFVDLPTRAERASIWRVHLARRLRNPAVAGGLTLDEPLLAELAALSEGYSGAEIEQAVVGGLFDAFSERRPLRRDDLAQSVVSMVPLSVTQAERIDALRTWADTRAVAATAAEDWDGGARSGLRDEVPPPVAPPAARGQGGRAVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7B2</accession>
    <name>F4F7B2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10260"/>
    <dbReference type="EnsemblBacteria" id="AEB43170">
        <property type="protein sequence ID" value="AEB43170"/>
        <property type="gene ID" value="VAB18032_10260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10260"/>
    <dbReference type="eggNOG" id="ENOG502ZBKE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062173_1_0_11"/>
    <dbReference type="OMA" id="AWSTSHH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025683">
        <property type="entry name" value="Protein_beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14350">
        <property type="entry name" value="Beta_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="352" mass="38375" checksum="1DAB6DCC479C34EA" modified="2011-06-28" version="1">MTEPVYRPVLAARRGELEALGHLDGVHVPLVAPIFQLSTTDVSTVDSLGRLPAGLLPAVDVSALPDGAEAELARWGVPLMPVICLTDGERRLAAHGITARAYAGRAVVRLRIGQDRAGPHATNAVVERIWRYARLAPEQCDLLVDCGEVGCRADVRAVEPRARRALEWARRHAWCSVSVVAGGMPPALSRLPTDEPVRLCRWDWLLWQRLADLDVGFGDYGVASAAPDVEPSADRLPTVRYTGDDAWWIYRWSRRGGRGDLRVADLCRALVSAPHWPSAGANFSWGDHEIFRRARRVAGAGSTANWLAWSTSHHLAQVLAALHQPARGGEPRSGPPPPRSRAPRGGQPRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7H3</accession>
    <name>F4F7H3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_16540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733072.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16540"/>
    <dbReference type="EnsemblBacteria" id="AEB44412">
        <property type="protein sequence ID" value="AEB44412"/>
        <property type="gene ID" value="VAB18032_16540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16540"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_11"/>
    <dbReference type="OMA" id="GMVNFFG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="34669" checksum="AC2A191D5D75EF25" modified="2011-06-28" version="1">MTTLTTERASATTDRISALRIRILRDPSFGILVLLVVVSVVMAFVEPTFATAGNLTNIINAMITVSFLAIGMTVVLIAGGLDLSVGSVMALTAGVVASCLNNGMPLAVAFLAALAVGAGIGLINGLLITKLGIPDFIATLAMLGLAGGLLLYWTAGVPVLGYMTNAYYYIGGLRQLIGPITVPMLLVVAVGIAVSVFLRRTTYGVKFYAVGSSATGAMNAGIRVDRIKIAAYVISGLMAAIAGIHIAGRTTTVPPLIGNGYEISAIAAAVIGGASLFGGKGRVIGALVGALTLTLTRNIINLTGVESSWQAVVTGLVLIIAVLANQAWSGIARSIGAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7V7</accession>
    <name>F4F7V7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein marr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29306"/>
    <dbReference type="EnsemblBacteria" id="AEB46932">
        <property type="protein sequence ID" value="AEB46932"/>
        <property type="gene ID" value="VAB18032_29306"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29306"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_22_2_11"/>
    <dbReference type="OMA" id="IRMRTVC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="19908" checksum="4417BD82D5D0FC2C" modified="2011-06-28" version="1">MAAEVDVAAGALLTVWDGARERTANRISTAQLRAVMLVERQDGINLRRLAAGLDMLLSSASRLCDRLVAAGMLEREPGRADRREISLHLTAEARSLLDELREDRRQHLAAILADMTPEGREALLRGLREFDEAARARVVRPVSPLVPQPDEPDTGHLSEVRDVVDAPLSWSNGETAVFRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F866</accession>
    <name>F4F866_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear export factor GLE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731898.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10545"/>
    <dbReference type="EnsemblBacteria" id="AEB43227">
        <property type="protein sequence ID" value="AEB43227"/>
        <property type="gene ID" value="VAB18032_10545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10545"/>
    <dbReference type="eggNOG" id="COG4549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087540_0_0_11"/>
    <dbReference type="OMA" id="NKEVVRW"/>
    <dbReference type="OrthoDB" id="1828335at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307727" evidence="3">
        <location>
            <begin position="28"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="33"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="25859" checksum="194849CECD97A4A9" modified="2011-06-28" version="1">MIRHRRTVGAIVALTLGTVATAVFGFAAPASAHVSISPSEAKQGGYGRFAFRVPNESDEASTTKLEIFLPENAPVGSVSTMPVPGWTVAVEKRRVDPPVQVHGAEISEVISKIIWTAEGAAAAIAPGTFQEFPVSMGPLPDVDQMVFKALQTYSDGGVVRWIDEPQPGGEEPATPAPVLTLTAATSTAEPTDAPTASPGAPAQAAEDDEDGNGLAVGLGVAGLVAGLAGLVLGGLAFARTRRAGGPGQGGEATAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8F0</accession>
    <name>F4F8F0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733150.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16955"/>
    <dbReference type="EnsemblBacteria" id="AEB44495">
        <property type="protein sequence ID" value="AEB44495"/>
        <property type="gene ID" value="VAB18032_16955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16955"/>
    <dbReference type="eggNOG" id="ENOG5031T2T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2482432_0_0_11"/>
    <dbReference type="OrthoDB" id="1868839at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="87" mass="8821" checksum="45B93490CF01D763" modified="2011-06-28" version="1">MLVSSDGTRTPGTAALFAEPARKGGTPPWAGDFRPANSAGNGPKNAVGKTFTLELPDGSTGKVVIQNLKRGKGGVVLALMGEDAPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8I0</accession>
    <name>F4F8I0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17105"/>
    <dbReference type="EnsemblBacteria" id="AEB44525">
        <property type="protein sequence ID" value="AEB44525"/>
        <property type="gene ID" value="VAB18032_17105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17105"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070456_1_2_11"/>
    <dbReference type="OMA" id="ALCRLIC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="27529" checksum="330B5A5432C060A4" modified="2011-06-28" version="1">MHENLAVADRWVRTLTTSGTHRIQLVCFPHAGGTANYFLSLARALPPEIEVLAIQYPGRQDRRAERARTSIAELADEADAVLRARLAGPYAFFGHSMGAVIAHEVTQRRARAGARLPQRLFVSGRRAPDQPPCRPDPPRTDVGILDDLREAGGTHPLFLTDAELRAELLRVMRADYQAIDTYAWHSHPPVNCPITALTGDADPQASVAAVRAWSAHTSAGFDLRVFSGGHFYLDEHRPDVAGAIGQGLLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8I8</accession>
    <name>F4F8I8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733188.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17145"/>
    <dbReference type="EnsemblBacteria" id="AEB44533">
        <property type="protein sequence ID" value="AEB44533"/>
        <property type="gene ID" value="VAB18032_17145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17145"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="OMA" id="HTNNIFA"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="22939" checksum="916056FF62DC4E67" modified="2011-06-28" version="1">MRVVIAEDHALLRDGLTRILRAYDFDVVAAVDNGPALLPTLITHRPQVAVIDVRLPPTFTDEGLQAAIAARTRIPGLPILVLSQHVEPLYARELLSTPHGGVGYLLKDRVSHVGEFVDAVRRVAAGGTAMDPEVISQLLARREPLAALTPRERDVLGEMAEGRSNAAIGAKLRITEKAVSKHINNIFTKLDMPPSTDDNRRVLAVLAYLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8J3</accession>
    <name>F4F8J3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17170"/>
    <dbReference type="EnsemblBacteria" id="AEB44538">
        <property type="protein sequence ID" value="AEB44538"/>
        <property type="gene ID" value="VAB18032_17170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17170"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2496991_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="86" mass="9283" checksum="1194399273D1124E" modified="2011-06-28" version="1">MGFGGRLEVGPSRTDGRIEVVIRGNDEHILAGELAGLVEWIEVTGPPGVRDHLASIGNALVERYGSNRQGRRTAAVSEDAARHRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8L2</accession>
    <name>F4F8L2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734407.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23285"/>
    <dbReference type="EnsemblBacteria" id="AEB45755">
        <property type="protein sequence ID" value="AEB45755"/>
        <property type="gene ID" value="VAB18032_23285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23285"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982936_0_0_11"/>
    <dbReference type="OMA" id="KTRTTSQ"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="292" mass="32012" checksum="D9F8D506AD7A7A26" modified="2011-06-28" version="1">MNLDKLWTDLATELLGVLTAYRSRVADLDVREKADRTLLTEADLAVEELIINRIRALDPAARVLAEESGSGTWRPGEDEEPERIWVIDPIDGTAEFVNPSSAEFCSVICLLERREPVATLIVAPELGTDRTPIVVVASHAERTITVNGRPARHINEPVRVASLTRSARSEAPPHETAMAAAGYTLKTRTTSQTLDMLRTAVDLTDFAADAPRFDLFYRPRQKVWDGLAGLCLGEIVGLMSTDAKGVRHLPVSMETLAQPEPTFASTVMGRPEAVKWFVEQAQGSPTAIRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8W6</accession>
    <name>F4F8W6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735694.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29876"/>
    <dbReference type="EnsemblBacteria" id="AEB47046">
        <property type="protein sequence ID" value="AEB47046"/>
        <property type="gene ID" value="VAB18032_29876"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29876"/>
    <dbReference type="eggNOG" id="COG2154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081974_4_3_11"/>
    <dbReference type="OMA" id="NFAQMVG"/>
    <dbReference type="OrthoDB" id="1862336at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="97" mass="10551" checksum="6E549179437C7CC4" modified="2011-06-28" version="1">MAEVLTAEAVRDELGGLAGWSQDPAGITRTVELASFPDAIGLVDRVAATAEELDHHPDIDIRWRTVTFRCVTHSAGGVTRRDIELARRIDEIVGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F950</accession>
    <name>F4F950_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730752.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42078">
        <property type="protein sequence ID" value="AEB42078"/>
        <property type="gene ID" value="VAB18032_04760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04760"/>
    <dbReference type="eggNOG" id="ENOG503098R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155261_0_0_11"/>
    <dbReference type="OMA" id="RSLFWSG"/>
    <dbReference type="OrthoDB" id="2074507at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307523" evidence="3">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="157" mass="16420" checksum="D14F4B22093A7C84" modified="2011-06-28" version="1">MAMVNLSARRPHRSRIAHAFGILALFGAAITLMVLVRDPALSSTRLAEPVPAPEITVVEATPPTGSGGSPPAWDEFDDDRTAPLTPNDSAALPDGSAAMPGDSESSADSAHRAATSDRTGDRHSSDALSRSLFWSGVFGLAISLAGLGLVSTRRRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F986</accession>
    <name>F4F986_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04940"/>
    <dbReference type="EnsemblBacteria" id="AEB42114">
        <property type="protein sequence ID" value="AEB42114"/>
        <property type="gene ID" value="VAB18032_04940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04940"/>
    <dbReference type="eggNOG" id="COG4405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102450_3_0_11"/>
    <dbReference type="OMA" id="HFSEDME"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009326">
        <property type="entry name" value="DUF984"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39203">
        <property type="entry name" value="PTHR39203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="48"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="180" mass="19495" checksum="5666D7CF64585228" modified="2011-06-28" version="1">MDISFLSGIDRTARKAAAAWPKRHRAPTSWSAGTLGRMWPRIGDLRALALGTPGELRTHLNTLVLNGVKTATAGLLDEYASDGEELEHVGERLALVDDHDALLGVVEVTDVQTCRFAEVPWDFARAEGEGDRSIEEWRAGHAAYWARIGTPVTDDTQIVCLRFRLVSAGDGGIATGDLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F995</accession>
    <name>F4F995_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731960.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10855"/>
    <dbReference type="EnsemblBacteria" id="AEB43289">
        <property type="protein sequence ID" value="AEB43289"/>
        <property type="gene ID" value="VAB18032_10855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10855"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039484_0_0_11"/>
    <dbReference type="OMA" id="HAGKGGY"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="347" mass="38850" checksum="9327FAF269323758" modified="2011-06-28" version="1">MAFARDQWYVAAYGSEVGRELLARTVLGEPLVLYRTGAGEAVALADRCVHRRYPLSESRLDGDTIVCGYHGFTYDRTGSCVFVPGQQRIPRTARVAAYPVVEQDSFVWVFIGDRDRADPATIPRAPWLTDPRYAVVRGMAPLNARYGLLVDNLMDLSHETYLHGGYIGTPEVANTPITTEVDDERGIVYVSRHMDDAECPPFYARSTGIQGRITRWQDIEYHPPCLYLLHSRIAPQGVYPPAQGEDNEAFHAEIVYAITPSTEHTTYDFWAVARDFAIDDESVSEYLHQSNHTVVMQDVTALNILEQVIAAEPEKYQELSINIDTGGLAARRLLARLVDAGRVEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9J2</accession>
    <name>F4F9J2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44570">
        <property type="protein sequence ID" value="AEB44570"/>
        <property type="gene ID" value="VAB18032_17340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17340"/>
    <dbReference type="HOGENOM" id="CLU_2496992_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="86" mass="9606" checksum="A26D5897BED641BA" modified="2011-06-28" version="1">MTRPAGHGCGEHTHRIRYGEVAAKRISPTGPSPVDRIRNMLGRPQIAGREEDLCAAFSERFGQKSPRTPCRTGDDDTHTIKIHDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9L1</accession>
    <name>F4F9L1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733244.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17435"/>
    <dbReference type="EnsemblBacteria" id="AEB44589">
        <property type="protein sequence ID" value="AEB44589"/>
        <property type="gene ID" value="VAB18032_17435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17435"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="RIHKFNE"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="38743" checksum="0E43E532E9D87046" modified="2011-06-28" version="1">MAGIEVTALHKRYPDGTVAVEQVDLSIGHGELFVMLGPSGCGKTTTLRAIAGLERQTKGDIRIGDTLVNDLPPAERDIAMVFQFYALYPHLKTRDNLAFPLRAEGLPKSEVLKRVDEAARLMRLGPLMDRRPRQLSGGEQQRVALARALVRRPRAFLMDEPLTNLDAELRADMRTEIKHLQGELGATMVYVTHDQVEAMSLGHRIAILNKGRVEQIGTPLEVYDRPASLFCAAFIGSPPMNLIEVEVADGALRAQGGLALTPPPGLSRDCHLVAGVRPEALEVTAPGAERSVPARVVSAEWLGDEIIYVVDHGGQRDVRVRMPPTVRFDADAPVGLRHTGATPAVYDLRTEELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9N2</accession>
    <name>F4F9N2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733265.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17540"/>
    <dbReference type="EnsemblBacteria" id="AEB44610">
        <property type="protein sequence ID" value="AEB44610"/>
        <property type="gene ID" value="VAB18032_17540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17540"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="MITAESQ"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="24251" checksum="3A2F39E118FA8CE1" modified="2011-06-28" version="1">MITAESQIKVLLADDEKLVRSGFKLLLDLEDDITVVGEATDGAEAVEAARSARPDVVVMDIRMPKLDGIQATTQISRMRGLERVRILILTTYDTDANVFDALQAGASGFLLKDAGPAELLHAIRVVAAGDALLAPRITRRLIGQFTARRTAAGAAQERLAVLTDREREVLALVGRGLNNDEIGGELFLSPATARTHVSRAMAKLGARDRAQLVVIAYQTGLVSPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Q8</accession>
    <name>F4F9Q8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_23680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734486.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23680"/>
    <dbReference type="EnsemblBacteria" id="AEB45834">
        <property type="protein sequence ID" value="AEB45834"/>
        <property type="gene ID" value="VAB18032_23680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23680"/>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_12_0_11"/>
    <dbReference type="OMA" id="RVIAGWD"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="13085" checksum="A8211819FA3B9B5C" modified="2011-06-28" version="1">MNQAASKPEIGPIEGAPPADLVIEDITVGDGPEAQAGQVARVHYVGVAHSTGAEFDASWNRGEAFEFPLGGGRVISGWDQGVVGMRVGGRRKLTIPPHLGYGSRGAGGVIKPNETLVFVVDLLGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9V7</accession>
    <name>F4F9V7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734535.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23925"/>
    <dbReference type="EnsemblBacteria" id="AEB45883">
        <property type="protein sequence ID" value="AEB45883"/>
        <property type="gene ID" value="VAB18032_23925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23925"/>
    <dbReference type="eggNOG" id="ENOG5031B2D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1218826_0_0_11"/>
    <dbReference type="OMA" id="PFGTLAY"/>
    <dbReference type="OrthoDB" id="1844248at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="26457" checksum="C34C91AFBA689436" modified="2011-06-28" version="1">MGALRRPFLLLAMLALVLAVGVEVGAGLLLGGSDAGAALAGSAADLGVEVSDVSGVSEPSGRGTGYLALVDAAALWTTGLFCLGLVLPERIHGRVQGVATLIFSIVLIIVAILALVIAFVELSIMVSLFLAPPFGTLAYLALWGFFPVGDSAVLLGLVLLLKLAWAGLLLLAQPKFIQNKGLVLLIGTSLLCTVVLEFLHRLVPVILVSILDDLGAIVFAVIAIIWALVLLIGAIPAIVKAIRATAALRAEPDPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA29</accession>
    <name>F4FA29_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00280"/>
    <dbReference type="EnsemblBacteria" id="AEB47140">
        <property type="protein sequence ID" value="AEB47140"/>
        <property type="gene ID" value="VAB18032_00280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00280"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_19_1_11"/>
    <dbReference type="OMA" id="YPHMPTG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="346" mass="36741" checksum="19A6CA6B0008C87A" modified="2011-06-28" version="1">MKAAAHPGGLINLSMGTPVDPVPGVIQRALADAADAPGYPLTAGTVALREAITAWVTRSCGARPDGLGVLPTIGSKELVAWLPTLLGLGPGDVVVVPSIAYPTYEDGVRLVGATTVRADSLTAVGPTSRVRLVWVNSPGNPTGRVLPATHLRKVVDWARERGAVVASDECYLPLGWTAQPVSVLAPEVCGDSYDSVLAVHSLSKRSNLAGYRAGFVAGDPALVAELLKIRKHAGMIVPAPVQAAMVAALGDEEHATEQRERYRARRETLWSAFTNAGFRVEHSEAGLYLWLTRDEDCWDTVDWLARRGILVAAGVFYGPGARQYVRAALTESDERIAAVAARLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAB3</accession>
    <name>F4FAB3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730848.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05240"/>
    <dbReference type="EnsemblBacteria" id="AEB42174">
        <property type="protein sequence ID" value="AEB42174"/>
        <property type="gene ID" value="VAB18032_05240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05240"/>
    <dbReference type="HOGENOM" id="CLU_1337046_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="205" mass="20975" checksum="7A3478B4C2BD96FA" modified="2011-06-28" version="1">MSDVQQALLEVWNSDPDHYPAAPDPLPGVRARLRRRRRAQTAGVGLALSAVVGIGAVGVMVAERSAVPPTGPSSASPADSAGPVAPDLRGLPPYLGAVDATEAVLKSQQPQLVPTGTRAAYEGSGPVTRVIAVFDFTAPTGLPGTPREVTVPSGAQVLTTDDPVTSTAYLTAWRTDGSSLFLAVTAAEAEVRSATIDALIEANLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAR0</accession>
    <name>F4FAR0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/sulfonate/bicarbonate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_17865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733330.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17865"/>
    <dbReference type="EnsemblBacteria" id="AEB44675">
        <property type="protein sequence ID" value="AEB44675"/>
        <property type="gene ID" value="VAB18032_17865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17865"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_0_11"/>
    <dbReference type="OMA" id="GIGHMIV"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="30020" checksum="57109EE60E3883A1" modified="2011-06-28" version="1">MTVDVRTDPAPASVAPRRPARRRSAKPRLTRIGLSVLSVALGILVWDLVSRNYTAFFLPSPMLTWQGAVDLVRDGTLWDSVTASSTRILTGWALGVVIGVPVGLLMGCIPWLRLMLDPYIQFFRFVPPIAFVTLAIIWLGPGEASKVALIFYTTVFIVALNTLAGVLAVDDLRLRAARALGASPLRTLVSVVLPSTVPHVVTGARLAMGNSFLTIVSAEIVAAQSGLGSLIWTARNYAKTEWVFVGILALGLLGYLFDWILRTVTRTTLRRYGVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAR9</accession>
    <name>F4FAR9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR-like family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733339.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17910"/>
    <dbReference type="EnsemblBacteria" id="AEB44684">
        <property type="protein sequence ID" value="AEB44684"/>
        <property type="gene ID" value="VAB18032_17910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17910"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_1_11"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12844" checksum="6DD333CBBECC0619" modified="2011-06-28" version="1">MDNTRERITTNIRKGVLEYCVLALLSQRDMYGLELADWLAARGLIASEGSLYPLLARMRQAGSVETHWLTPEQGHARRYYAITTQGRTQLRVFAAVWRDIQPHVDQLIAEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAU7</accession>
    <name>F4FAU7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734562.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24060"/>
    <dbReference type="EnsemblBacteria" id="AEB45910">
        <property type="protein sequence ID" value="AEB45910"/>
        <property type="gene ID" value="VAB18032_24060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24060"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1159163_0_0_11"/>
    <dbReference type="OMA" id="MPLHAIT"/>
    <dbReference type="OrthoDB" id="1705284at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="243" mass="27378" checksum="24514553637F6CB5" modified="2011-06-28" version="1">MELPPYLATMPMHAITEMHGEPGLRERFRLECAAFDADARRRFGEALELAARLHRDDRRSREPYVNHLLRVAIRLMHHYQVREPDVIVAGLLHDAVEDHPAELAGEAYTGGDPTSAALAVLADRFGARVARLVAAVTNPPWDPERDRNEQYREHLVHSLDGEPWARVIKVSDFTDNGVGVIHSVGPKVEALARKYRPLVPVFRDLVTRADTPLSAPVRRHILDQLDLAEERFSAILDQPAQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAV5</accession>
    <name>F4FAV5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_24100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734570.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24100"/>
    <dbReference type="EnsemblBacteria" id="AEB45918">
        <property type="protein sequence ID" value="AEB45918"/>
        <property type="gene ID" value="VAB18032_24100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24100"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_5_4_11"/>
    <dbReference type="OMA" id="VLMVPHA"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="30619" checksum="366724B21C3068B3" modified="2011-06-28" version="1">MTTAVLTRVRRLPRLRPGRLGATVAGTVLAVAVLACLLAPVLWPLDQSAIDLSQTRLAPSPAHPAGTDDLGRDVLLRSIYGLRVSLLVGVFAAVVAAVIGGAVGALAGTLGGWVDRILMRLVDTIAAMPHLLLGIFIVAMLRPSLGAVVLSVGLTHWLSTARIVRSELLSLRHRPFIDAAVSGGAGRMRVLTRHLLPHVLPRLALATTLMIPHAVWHETALSFLGLGLPPHLASLGNMINDGRGSLLAGAWWASLTPGLVLIVVTLALATLTAHWRDHLDPRVRAELQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAZ4</accession>
    <name>F4FAZ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator, Fur family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734609.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24295"/>
    <dbReference type="EnsemblBacteria" id="AEB45957">
        <property type="protein sequence ID" value="AEB45957"/>
        <property type="gene ID" value="VAB18032_24295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24295"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_0_11"/>
    <dbReference type="OMA" id="DHPHADT"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="143" mass="15377" checksum="76A2B9AB23ACF041" modified="2011-06-28" version="1">MPTSGDLEQLLRDAALRVTRPRVAVLNAVYAQPHADTESIITAVRRDLPNVSHQAVYDVLRALTAAALVRRIEPSGSVARYEARVGDNHHHAVCRSCGLIADVDCAVGAAPCLTASDDHRFAIDEAEVIYWGLCPDCSTAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB04</accession>
    <name>F4FB04_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_24345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734619.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24345"/>
    <dbReference type="EnsemblBacteria" id="AEB45967">
        <property type="protein sequence ID" value="AEB45967"/>
        <property type="gene ID" value="VAB18032_24345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24345"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_14_0_11"/>
    <dbReference type="OMA" id="YLALWVP"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="174"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="407" mass="42151" checksum="9D96D3449F8E81A6" modified="2011-06-28" version="1">MRTYSELFTVAEFRNLFLANCAGIAAHTTSALALGSLTYATTGSALLTALSMFGAPLAGVLGSLTLLSAADSLPPRRALSLAALVALVGAALQVVPGLPLWARFAVILIVAYVGSITGGARWALINDILPAGGYVLGRSAMNVSVGVMQIAGFGAGGLLLVWLNPYQVFGVAVVLRAVALAVTRFGLRERAARSAATASTRRTLRVNRQLWREPGCRSLYLNLWLPSGLVVGCEALFLPYAGERAGFLFAAGALGMLTGDVLVGRFLSPAARDRWVLPLRLLLPVPYLVFLVGPGLPLAMLLALVASVGFAASLPLQERLIARAPAEARGQVLGLHHNGMMTGQAVCAALAGLLADLMATHWAVALLAGLSLTTTALLTPGLASTRPAPVTASPGNNRPAVVGRRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB16</accession>
    <name>F4FB16_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24405"/>
    <dbReference type="EnsemblBacteria" id="AEB45979">
        <property type="protein sequence ID" value="AEB45979"/>
        <property type="gene ID" value="VAB18032_24405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24405"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_5_6_11"/>
    <dbReference type="OMA" id="HIFHSST"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="199" mass="21732" checksum="1186A3FA25E71682" modified="2011-06-28" version="1">MTAALVVIDVQESFRQRANWTACSQPDIVGQVNRLVEAARSRGDLVVWVLHSEPDSGDVFDPARGFVRLIDGLQPAEGEPVLTKYVHNAFTTTRLQQLLTVHGVREVTVCGIRTEQCCETTARLAADLGYEVTFVVDATATMPVEHPDAPAGRTIAEILADPRTLNTDEIIERTAYALSGRFATIRTVDEVTTPVGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB22</accession>
    <name>F4FB22_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_00415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00415"/>
    <dbReference type="EnsemblBacteria" id="AEB47167">
        <property type="protein sequence ID" value="AEB47167"/>
        <property type="gene ID" value="VAB18032_00415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00415"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="RYFEVMD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="322"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="556"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB47167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="585" mass="62473" checksum="1B177B22C2A1C0AC" modified="2011-06-28" version="1">MEFSVLLLAGFASTGAGIAVPLVAQRVVDGPVADRDLRGLFQLAGLALTLGLIEALLIFIRRWVQSSSSVAMEATIRDDIYAHLQRLPASFHDRWPSGQLLSRITSDLSVLRRFLSFGLLFLVLNLTTYLVVVVLLVRLHPVLGLLVAASAVPLFVIARRFGRHYHAASRRMQDQQGDVATQVEETAQGLRTMKAYGRGPQLTARFVASTRALHDTGVGKGRLLGRTAALLDLVPNLTLGIVLVAGAAAVADARLTIGQLVAFVSLQLMLIWPVQSLGWIIANGQEAATAADRIQEVLDTAPAIVDAPDAVTLARSAVRGRLRFEAVTFRYPGTAAPVLRGIDLTVEPGETLALVGATGSGKSTLLSLVPRLHEVETGRITLDGHDLRDLRLASLRRLVAVAFEEPTLFSMSVWENLTLGRPDAGTDEVRAALALAQAEFAYDLPWGLDTRLGEQGLSLSGGQRQRLALARAVLVRPTVLVLDDPLSALDVHTEALVESALKRVLRDMTALLVVHRPSTIALADRVALLEDGRITAVGRHTDLLAEVPAYRALLSAEPTGTPSSTAGAPSSTVGTAPDGTPLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC27</accession>
    <name>F4FC27_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase GroES domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24635"/>
    <dbReference type="EnsemblBacteria" id="AEB46025">
        <property type="protein sequence ID" value="AEB46025"/>
        <property type="gene ID" value="VAB18032_24635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24635"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_11"/>
    <dbReference type="OMA" id="WAKAQSF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="382" mass="40415" checksum="25EE007431007170" modified="2011-06-28" version="1">MRSVDVCEVPDPEVQEETDAVVRITSTALCGTDLHMYDGRTGAQPGLVLGHEPLGVVERVGSAVQTVRPGTRVVIPTHLFCGVCAMCARGLSALCLRARPDGLGAAYGYVGMGPYPGAQAELLRVPWADANCLPLPGEPGDAYEDDFVLLADAFVTGWHAAATLADVRAGDTVAVFGAGTIGLLAAYAAGLLGARTVYSVDHVDARLGKAEELGAVPMDFRQGDPVEQIRADRARRGLPLGEEKLPGVDKVIDAVGFQAHDRAHPDRERADQVLADAARLVNPGGAVAVAGVYPESDSTPQAGGSADGHLDAPWGTFFAKAVALRFGRTHDRRYTRLLRDLVTAGRARPGRIVTHHGSLADAPGCYQRFDRRQDVIKAVLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC91</accession>
    <name>F4FC91_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735914.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00930"/>
    <dbReference type="EnsemblBacteria" id="AEB47270">
        <property type="protein sequence ID" value="AEB47270"/>
        <property type="gene ID" value="VAB18032_00930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00930"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324608_0_0_11"/>
    <dbReference type="OMA" id="VNQWPAQ"/>
    <dbReference type="OrthoDB" id="2014347at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="863" mass="86221" checksum="A25E3C7BEE1F7389" modified="2011-06-28" version="1">MANRTLSRLLLTAFGVSLLAGAGQLGLAFGFGIVRLTGAFSGATVNQWPAQLVWVGWFAANAAVIGAVLTERTARQDRQLTGTGRQLAVAGSAALGATVVAPLCMQPARNAELISVDPVWAVAICAVLGAIVGAGAALAVLVRPPFAWNMAAVAGAVWLIALLSVVPSLGASGPLTPVRLGVLEPVWFSADTAQQLALLILPMMTLLAGVAGGWAARWRGHPPLVSGPSGVAGPVLVAFAYLAAGPGDSADRYQLAPYYGALIAIAVGALGSTAAALLPWPLTGRSRPDTQAIEPTAILQPLPPTPALPTSPSRPTGQQPADPPPHWQWPDQRTSSLPTAAGVAPTRPDTPSLSAPAPAGPAEHTTVGAEDTSSAATEKSVDAPPATVGVATGAGLDAQELPAADDRHPAPATGRTPAAEAPAPADAATTTVEPLRPDAPASAETPATPDDAELAVDPAPVGDGSDIPRAGRTARSPRAATRPSTPGPASPSDPTSGLAPNPGQAPAPGQAPAPGQASPSDPASDPAPTSGPLADPAPAGKTPTPRRTRKPRTSTTAAGSDQPSEDGQAPAPTLHQPAHVVPDANLAPPADTAPPADTQSATAEPAVDTPPVATPPVAALPVADAQPVAHTTGSPWPTGGTGGSAATVRPEPTPRPRHRLSLPELNPAASWNAFAPTRPADPQPGDAKTGAAQEGRAAGGPAAVEPPTPTGRGGIDPAPPAGPAAAPTGPAATSPAGLDPASPAGLDPVTTAREVSAAFAAAPSLSSDPAATARDLSAAFTRPPAVAPEDVQPSGERDKGLRGLFRRGKPRPDNTEGGEEPLPAQDEEYVDWVTGLGRPVADDEPGPKKSRRSLRSTGRHHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCC8</accession>
    <name>F4FCC8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ordered locus">VAB18032_01115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735945.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01115"/>
    <dbReference type="EnsemblBacteria" id="AEB47307">
        <property type="protein sequence ID" value="AEB47307"/>
        <property type="gene ID" value="VAB18032_01115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01115"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_11"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="95" mass="10817" checksum="4FCB4FD29E987DE8" modified="2011-06-28" version="1">MSENTTTAGAELVRGRRKVREGLVVSDKMDKTVVVEVEDRVKHALYGKIMRRTSKLKVHDEQNSAGIGDRVLIMETRPLSATKRWRLVEILEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCS9</accession>
    <name>F4FCS9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12295"/>
    <dbReference type="EnsemblBacteria" id="AEB43573">
        <property type="protein sequence ID" value="AEB43573"/>
        <property type="gene ID" value="VAB18032_12295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12295"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033064_0_0_11"/>
    <dbReference type="OMA" id="AAHITNI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307627" evidence="1">
        <location>
            <begin position="33"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="391" mass="41356" checksum="21CD6E21D4D1E494" modified="2011-06-28" version="1">MIAVDALVARRRRALRIVVLFLAAVVLVTAGAVLVGPTLRSPDQLAADAAPPSPSLVTAVVERRTLVEPVVLRGRVQPGASVRLLAPPAAMGPSSVVTKVPVRKGDRIREGQVLLERSGEPLFALALRFPLYRDLTTGAQGPDVVEVQRALRRTGYSAPTTGVLDGTTLRQLAKFYRDRGYRLGSAQEDRRSGQSRAVQMPQSAVVVIDRTGRRISKVHARVGQTLVDPKTPIVELDGQAPVIVATAAVDQAALIRPGQQVDVTDELGETRTKARVSEVSEQATSGPDGQTGIEIRLKFAEAPMSGGTNRSVRLDVRTTAAAEVLAVPVSAIYSRPDGSMFITVVDEDDATTDVTVLTGQIAGGWVELREPVPSPVAAGSSVLVGEQTAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCT4</accession>
    <name>F4FCT4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12320"/>
    <dbReference type="EnsemblBacteria" id="AEB43578">
        <property type="protein sequence ID" value="AEB43578"/>
        <property type="gene ID" value="VAB18032_12320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12320"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_4_11"/>
    <dbReference type="OMA" id="FSEEPYG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="42"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="29217" checksum="9FEE915F5818A295" modified="2011-06-28" version="1">MAAIAAAAGLAVTMAACGGDSDEAGSGTGATGIVGKAESQKKLVIGVKADQPGLGLQTGSQYEGFDIEIGKIIAKGLGVDAGNIEWKTTVSANREPFIEQGTVDLVVATYTINDERKQKINFAGPYYIAGQDLLVKSDSTITGPDQLAGKTVCSVSGSTPAKRIQENYPDARLQQFDSYSKCLPLLDGGQVDAVTTDDIILAGYAAQDQYAGKFKVVGSTFSDEPYGIGLKKDDTTGCEKVNEILKAAAADGSYKAAWDTTLGKSGTPAPELDTTKLTHCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCT8</accession>
    <name>F4FCT8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732251.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12340"/>
    <dbReference type="EnsemblBacteria" id="AEB43582">
        <property type="protein sequence ID" value="AEB43582"/>
        <property type="gene ID" value="VAB18032_12340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12340"/>
    <dbReference type="eggNOG" id="COG5552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170430_1_0_11"/>
    <dbReference type="OMA" id="MCSDITR"/>
    <dbReference type="OrthoDB" id="1811614at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7357" checksum="DAD037A69A3FD150" modified="2011-06-28" version="1">MCRSIKTLREPYTPEVTDADVEAAALQYVRKISGFRAPAAHNAAAFDAAVAAVAAATRNLLDDLVVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD16</accession>
    <name>F4FD16_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18730"/>
    <dbReference type="EnsemblBacteria" id="AEB44848">
        <property type="protein sequence ID" value="AEB44848"/>
        <property type="gene ID" value="VAB18032_18730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18730"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010779_3_0_11"/>
    <dbReference type="OMA" id="GPAAYWD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="SSF110221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307643" evidence="1">
        <location>
            <begin position="24"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="AbfB" evidence="2">
        <location>
            <begin position="355"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="487" mass="53307" checksum="B0C33DD967D0BDA7" modified="2011-06-28" version="1">MSALLAAACLLLLPAAQAPHAGAAAAGPRAEAAALDPFTGYLMAHFTGESANGEQIYLAHSSDGLTWRDLNNGGPVLLSTLGTRGVRDPALVRSPAGDRYWIVATDLRIASGTSWNDAANRGSTSLVVWESRDLVNWSTPWLINVAGAIPGAGNAWAPEAIYNQATGDYVIYWATNSPRNGVTKHRIWYVRTTDFRSFTAPQLYIERPTGGQGIIDTQIIEVPNSVGGYRYYRASADGHIAIEASNSILGTWTSLGNLSHLGISNGTGGGNVVEGPMWMQFNGRNEWALYLDQYATGRGYLPITSTNLGSVTNFRTRSDYHMGASRKRHGSILNLTAAEQSRVLARWPSNAPVHRIQAYTHQDRYVRHANYDVRIDANVNPAQDAQFRVVPGLANNSGYVSFESVNYPGYYLRHYGFDFVLAANDGSSVFAADATFRQVAGLGNGGWSSFQSYNYPDRYIRHYDYQLRLDPITDTQGRNDATFRLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD44</accession>
    <name>F4FD44_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ordered locus">VAB18032_24880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24880"/>
    <dbReference type="EnsemblBacteria" id="AEB46074">
        <property type="protein sequence ID" value="AEB46074"/>
        <property type="gene ID" value="VAB18032_24880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24880"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_4_0_11"/>
    <dbReference type="OMA" id="LFGCPGW"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="249"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="350" mass="36452" checksum="4662891F733D9600" modified="2011-06-28" version="1">MALSSHVEYESTTRTAVIAGLGAYVPDQVVKNEEIAARLGVTTDWIRDRTGIEQRFVLNPEGATSDLAVEAARRALDSCGNPDIDFLILATCTPDHLFPSTAPSVASRLGFKGIAAFDLNAACSGFVYALSVSTGMLATGAYRTGLVIGADAISSILNHDDEITGPIFGDGGGAVVVRAGHLGETGSVSVQQLGSDGDLLDIMKTPGGGSRQRAAGVPVDIDSSYFTMSGRAVYKHAINRMSTVSRSVLERLGWTPDDVDWLIAHQANRRILTATAEEIGIAPERAVINVDRVANTSAASIPLAMVDAVESGALTAGDKVLLAAFGGGATWAAAGLTWPELTLAPTQTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD78</accession>
    <name>F4FD78_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Atpase associated with various cellular activities aaa_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734760.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25050"/>
    <dbReference type="EnsemblBacteria" id="AEB46108">
        <property type="protein sequence ID" value="AEB46108"/>
        <property type="gene ID" value="VAB18032_25050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25050"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="OMA" id="RAGQAMI"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="49"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="241"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="331" mass="35646" checksum="EF3B1DD39364AA27" modified="2011-06-28" version="1">MNSQEPLNHQEVQGFAALAARLAENVNAVVLGKPQVVRLALTALFAQGHVLLEDVPGVGKTTLARAIAATVKGQWRRIQFTPDLLPSDVSGVTIFNQATRGFEFHPGPVFANIVIADEINRASPKTQSALLEVMEERTVTVDGVRHPVPQPFLVVATQNPVEMDGTYRLPEAQLDRFLVKLSVGYPDESVEVEVLRGATVRSPEALAAITDTTTIGEMVRMARRVHIAEPLYTYAVRLAAATRTHPQVRVGVSPRGVIALTRAACAYALIDGRGWIMPEDLKTLAEPVFAHRLLLTPDAQVRGVTAGDVLRQAVASVPVPLPSGQPAPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDH9</accession>
    <name>F4FDH9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736025.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01530"/>
    <dbReference type="EnsemblBacteria" id="AEB47390">
        <property type="protein sequence ID" value="AEB47390"/>
        <property type="gene ID" value="VAB18032_01530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01530"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OMA" id="CHPNITN"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="4">
        <location>
            <begin position="369"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="570" mass="60199" checksum="8C46EBB8379281D6" modified="2011-06-28" version="1">MGAEVRRGAQLLGERYRLIEQLGTGGMSVVWRGYDEVLGRQVAVKVLASRLASDRAFRHRIRSEAQAAARLCHPNITNVYDYGESQQVGLTVPYVVMELIDGAPLTARLSGVGVLPWREAVTIAAEVASALATAHARGVVHRDVTPGNVMLTATGVKVVDFGISALVGESEKSADGTLLGTPAYLAPERLDNGQVSPATDVYAVGLLLYRMLTGRLPWQAETTTQMLRAHMYREPEPMPAVPELPAGVAELVHRCLAKRPVDRPGTAELALTLAEAVGKIPAVPVSLADQRTDPMLLASAGTTILPWSVATDALPLTGLRTARRRDRRRRVEAGVAAVALMAVTAAVWGVTSRSPASGGIDQPTQARMGGEDRIPCQVSYALRKDSGKDFTAELSLTNTGDRELRDWTVRFAFPGGQQVTGASPVPARQQGHAVAVQAAPEHPALKPGATEKLRLTGTYTGTNPLPVEFRLGDEQCGVQVSGIAGSAPTPKPVKAAGGKAGSGGSDKAKTKPEKAKPGKKAEPGKKDTPAKKKGPDKKEQQAKGTPAKGKPEKTKAAKRGKPKTPPGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDJ1</accession>
    <name>F4FDJ1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731027.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06150"/>
    <dbReference type="EnsemblBacteria" id="AEB42354">
        <property type="protein sequence ID" value="AEB42354"/>
        <property type="gene ID" value="VAB18032_06150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06150"/>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067307_1_0_11"/>
    <dbReference type="OMA" id="MLVNKRE"/>
    <dbReference type="OrthoDB" id="1683794at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="26780" checksum="E1F93B444B6F6587" modified="2011-06-28" version="1">MTTSTVLAAAGAVSGGEAVTFWILAPLALAGAIGMIAARNAVHSALWLVLTMLSLGVFYVLQAGPFIGMVQIIVYTGAIMMLFLFVLMLVGRDASDSLIEVLRGQRIAAIGLGVGFAALLGSGAYRATQGTEAVGLEQANAGGNVQSIARLLFTDYIFAFELTAALLITATIGGMILAHVERRKEDRRDQVATMKARFAPGNYPGPKPGPGVFATSSSVATPARLPDGRLSDRSTPDILPVRELTAEETTLKGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDQ7</accession>
    <name>F4FDQ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drug resistance transporter, emrb/qaca subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_06480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731093.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06480"/>
    <dbReference type="EnsemblBacteria" id="AEB42420">
        <property type="protein sequence ID" value="AEB42420"/>
        <property type="gene ID" value="VAB18032_06480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06480"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_11"/>
    <dbReference type="OMA" id="GWNFLVQ"/>
    <dbReference type="OrthoDB" id="1558246at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="19"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="558" mass="58132" checksum="B37E2E8F899753DE" modified="2011-06-28" version="1">MTTEGRSEPVLNKGQLRLLMFGLMTGMLLAALDQTIVGTALPTIVGELGGISHYSWVVTAYLLASTASTPLYGKMADLYGRRPVFLFSIGTFLLGSLLAGLSQDMTQLIVTRGVQGIGAGGLITLAFTIISDVVPPRERGRYQGVFGAVFGISSVAGPLVGGYFAETNWRWIFYVNVPLAILAILVCSRVLRLVPFTRRKHAIDWLGATLLVAGVSCLLLALSWGGETYPWGSALIIGLFVAGAVLGLLFVLQEARVTEPILPLRLFRSATFALANGAGFVIGLVMFGSIIFIPLYLQIVKGASPTRSGLLMLPMMAGVIVTSVLTGRAMSRLGRYKWFPVAGAALLLVGMLLFTRLRVETSLWVAFGFMVVIGVGLGLCMQSLVLAVQNAVSMRDLGAGTSSATFFRSLGGSFGVAILGAVLSWRLTAELADRLPGAIAQLTPEEQAAAGATGGAGVSINDPAAILALPAPVRAAVQAAFVESLHLVFLTTGLIAIVALLVTLALPNEQLRGAGPQGATGGTDGLGGEGPAPGGKPLDKGSKSEAAADMEAKSQTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE70</accession>
    <name>F4FE70_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Malate synthase</fullName>
            <ecNumber evidence="2 7">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733594.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19185"/>
    <dbReference type="EnsemblBacteria" id="AEB44939">
        <property type="protein sequence ID" value="AEB44939"/>
        <property type="gene ID" value="VAB18032_19185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19185"/>
    <dbReference type="eggNOG" id="COG2225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_11"/>
    <dbReference type="OrthoDB" id="322024at2"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="536" mass="59479" checksum="66EB2479D1B05A18" modified="2011-06-28" version="1">MRYEVIGPMAERFDEVLTPEALEFLVTLDSEFAARRVALLDTRRARRDRFATGQLPDFLPETIGVRADPTWRVAPPAPGLEDRRVEITGPPERKMTINALNSGAKVWLADFEDATAPTWDNVIGGQLNLMDALDRRIDFTDPRGKRYALGEELATIVVRPRGWHLVEKGIVVDGRPISASLVDFGLYLFHCARRQLAAGAGPYFYLPKLEDHREARLWNDIFVFAQHYLKLPQGTIRATTLIETITAAFEMEEILYELREHSAGLNAGRWDYIFSIIKNFGQWPDFVLPDRAAVTMTVPFMRAYTELLVRTCHRRGAHAIGGMAAFVPSRDPEVNENALAKVRADKQREAGDGFDGSWVAHPGLVPTCREVFDAVLGERPHQLDRQRDEVSVTAADLLSVDKTPGQVTESGLRSNIAVALHYIDAWLGGAGAVALWNLMEDAATAEIARCQVWQWLHHGTPLAEGGSVTSDRVRALLAEELSALSEGRGDAERERAAQAARIVEETALGEDLPAFFTTGAYARHLGPRRRSLAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEB8</accession>
    <name>F4FEB8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_25430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734836.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25430"/>
    <dbReference type="EnsemblBacteria" id="AEB46184">
        <property type="protein sequence ID" value="AEB46184"/>
        <property type="gene ID" value="VAB18032_25430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25430"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OMA" id="YIVFQRQ"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="317" mass="34843" checksum="C854A2F9C93C81F6" modified="2011-06-28" version="1">MSTVTHTPAGSDQAPPPDRTPGPRTAVGGSRAGAKIFNGFSHLFLAVWAIMVVYPLLWVVMSALKTDSEVIRKPLSLFPETLQWGNFTRAWTEGHIGDFFLNTVLVLTGSVFLTMLLGSMAAYVLARYDFPGNRLIYYMFLSGLTLPVYLAAVPLFKGVYNMGVTLPFLGPNKHLMLILVYVAWSLAFTVFFMHSFFRTLPNAIAEAALVDGASHSRMFFSVMLPMAKPGLISIGIFNVLGQWNQWYLPTLLMQSVAGEPKNQVISQGLIELSVNQGYKSDWSGLFAGVTMAMLPVLIVYIVFQRQVQSGLTAGVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEH2</accession>
    <name>F4FEH2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736049.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01650"/>
    <dbReference type="EnsemblBacteria" id="AEB47414">
        <property type="protein sequence ID" value="AEB47414"/>
        <property type="gene ID" value="VAB18032_01650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01650"/>
    <dbReference type="HOGENOM" id="CLU_2304863_0_0_11"/>
    <dbReference type="OrthoDB" id="2078592at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="100" mass="10786" checksum="3855EE706F9963C0" modified="2011-06-28" version="1">MTARLDRRLLTSGMGVTVAQLVTLWADHTPARLPVPVICPGCGHPYSEKAPLCPTAAVVRPLLRRRRHEIPGAIDALTTNQLADLTGNRLSTALPAEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEM6</accession>
    <name>F4FEM6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47468">
        <property type="protein sequence ID" value="AEB47468"/>
        <property type="gene ID" value="VAB18032_01920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01920"/>
    <dbReference type="eggNOG" id="ENOG5032DUT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874204_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="318" mass="32756" checksum="C36C2EF5E7D2277A" modified="2011-06-28" version="1">MVTRLRPGRSGRSCNDEIICDDRVERAVDLPVRTPPPAAAVFAALREAGAAFAAPRAGAAFAAPRAGACRVAARVVVPVLAVLPAAVFAAAAVLRGAAFLAPAAVVRAVDVAVRADVVVRAGAVLRAAVALPAGAVFAAGAVLRGAAFLAPAVAVRAVAVVLRAVLALRAAAVVLRAVLALRAVLAVRAVPALRAVPVDAVRAGPVRLAGAAFARPVAVRADADCFVAVVFVLLARPAGPLLPRAAPPERSVLASLFTSSGLRRAEMPETPYRRNWPRMSSTRIREISDSEIRGVFGVWLLACRLVLVAVPPRPALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEN2</accession>
    <name>F4FEN2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01950"/>
    <dbReference type="EnsemblBacteria" id="AEB47474">
        <property type="protein sequence ID" value="AEB47474"/>
        <property type="gene ID" value="VAB18032_01950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01950"/>
    <dbReference type="eggNOG" id="COG3154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070584_1_0_11"/>
    <dbReference type="OMA" id="AWNWAPQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="148"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="27246" checksum="421A37F320BA3ADC" modified="2011-06-28" version="1">MHGSKDFWIGALRAEGPAFAAAVADAPPETPVLSCPGWTVTDLALHLTGIYQWVRDVAGSGRATAPEQRRSQRPELLPGLTAAQQWQQAYDDLMVLFDTLDPEAPAWNWAPQPKKAGFWPRRMAHETALHRWDAQLAIAAGEPIEAKLAADGVSEVLDTWLPAGRRAASGQWRGVVRLSATDAAQEWYLRLRGEGVALLDTGTILDHDEHHARVHVSGTASDLLLALWGRVSFDTLSVAGDPTLLDGVRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FES1</accession>
    <name>F4FES1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kojibiose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_06705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731138.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06705"/>
    <dbReference type="EnsemblBacteria" id="AEB42465">
        <property type="protein sequence ID" value="AEB42465"/>
        <property type="gene ID" value="VAB18032_06705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06705"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_2_2_11"/>
    <dbReference type="OMA" id="EAYCIPF"/>
    <dbReference type="OrthoDB" id="179460at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="7">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="5">
        <location>
            <begin position="328"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="6">
        <location>
            <begin position="701"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="362"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="593"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="792" mass="88696" checksum="5389AE5CE3D48016" modified="2011-06-28" version="1">MIRERAYPVEPWHVRETQLDVDVLAQSESVFALSNGHVGLRGNLDEGEPHGLPGTYLNSFYELRPLPYAEAGFGFPESGQTIVNVTNGKLIRLLVDDEPLDVRYGELLAHERVLDLRAGTLHRTLHWRSPAGREVRVHSTRLVSFRQRSVAAIRYEVEVADDRPLRLIIQSELVANEALPPQSRDPRVAAVLESPLQAEEELTTSDGGLLLHRTKVSGLRVAAAMGHEVDSASRTTIESEGYEDWVRTTVGCVLEPGQRLSVVKYLTYGWSSRRSLPALRDQVGAALAAAKLDGWGGLVREQREYLDEFWDAADVEIDGDPEVQQAVRFGLFHVLQAGARAERRPIAAKGLTGPGYDGHAFWDTEMFVLPVLTYTHPAAVRDALYWRFSTLEQAHERARTLNLAGAAFPWRTIEGPESSGYWPAGTAAFHVAAGIADALRRYVLISGDQQLEREIGLTLLVETARLWRSLGHHDRNGQFHIDGVTGPDEYTAVKNDNIYTNLMAQRNLRAAAEVAMRYRDEAFHLGVTDEEAAAWRDAAAAMHIPYDDEIDVHQQVEGFTRLQEWDFAHTPQDKYPLLLHYPYFDLYRKQVVKQADLVLAMHWRGDAFTDEEKLRNFLYYERRTVRDSSLSACTQSVLSAEVGYLELAHSYLREAALMDLHDLNENTRDGVHMASLAGAWIALVAGFGGLRDHDGVPSFAPRLPSRIGRLAFSLQCKGIRLRVTVRPHETTYVLHHHTDPDATMEVRHHGESVQVTAAEPVTLPIPPPPENLPPVEQPPGRAPLLRLPEHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFA2</accession>
    <name>F4FFA2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19525"/>
    <dbReference type="EnsemblBacteria" id="AEB45007">
        <property type="protein sequence ID" value="AEB45007"/>
        <property type="gene ID" value="VAB18032_19525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19525"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_2_11"/>
    <dbReference type="OMA" id="YCGMIRP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="41287" checksum="ECB7B4BFCC50B38C" modified="2011-06-28" version="1">MVQEEIRRRNASTLLRHVHLDGPLCRADLAARMGLNRSTIRALTTELARVGLVEEESPSDTGRAGRPSLLVRPASDRIYVLAFDVAVDRLVAARVGLGGVILDRREAVRPRAGPDLPQVVEVLARFGRQLHRAAPPSATCVGVGASYCGMIRPGDGMVRFGPDLGWVDQAFGAELGRRLGLGLPVLVGNEAHLGAQAEHLRGAGVGLQNLIYLHGDVGVGGGIIVGGRLLGGDGGYGCEVGHMVVNPYDGRACGCGSYGCLEAEVGERALLDAAGRPAELFGRDAIRAVTDDADRGDPAAREALRHVGDWLGIGVANLINLFNPGMVVFGGMLCDLYPGAADQVRARIARNVLPVAREHVKLRIAALGDDATLTGAAELAFTPLLTNPLTTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFD9</accession>
    <name>F4FFD9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_25715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734893.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25715"/>
    <dbReference type="EnsemblBacteria" id="AEB46241">
        <property type="protein sequence ID" value="AEB46241"/>
        <property type="gene ID" value="VAB18032_25715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25715"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_0_11"/>
    <dbReference type="OMA" id="IEHSHQP"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="653" mass="73188" checksum="7F5B59B34DAABDFD" modified="2011-06-28" version="1">MCGLLAFFSARGDAAAHRDSIAGALECLHHRGPDETGVEVVGDATGRYADGVFAHKRLAIIDVALSHEPLPYADGRYLLTFNGEIYNYIELREELIREHGARFATNGDGEVIVAGYHYWGEQVLTRLRGMFAFVIWDRQARRAFGARDYYGIKPLHYLETADGLYLASEKKALLPFAHSAHIGDAGVDTANLSHYLTLQYVPEPGTLHKQISRIGSGEYLTWTPGGRIDVRRWYRPVFRPAPVADEQKLYHEIRETLRESVRMHMRSDVPVGSFLSSGIDSTAVVALAREFNPNILTFTVGYDVPGYSEIDVAQESARHLDVTTIPTKIGPEDMIEALPKIVWHLDDPVADPALVPLYFVAKKAAEHVTVVLSGEGADEFFGGYTIYREPLSLSGVNGLPGGVQKGLRAVSKAIPQGVKGKSFLERGTTPIEQRYYGNARMFTEEEKQHLLRRYDPSVRYTDVTAPIYAECTELDDVTKMQYVDLYTWLRGDILVKADRISMAHSLEVRVPFLDREVFEVAAKIPVDLKLPPRSDATKYAMRQALQGVVPPAIVNRKKLGFPTPTRVWLRGEMYEWARHVLTTSGAGDLLDLSYALRLLEEHKREEADHSRKVWTVLIFCIWHAIFVAKTLDPGIQRNQSALLTKPVVGSMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFG0</accession>
    <name>F4FFG0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734914.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25820"/>
    <dbReference type="EnsemblBacteria" id="AEB46262">
        <property type="protein sequence ID" value="AEB46262"/>
        <property type="gene ID" value="VAB18032_25820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25820"/>
    <dbReference type="eggNOG" id="ENOG5032YIY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175454_0_0_11"/>
    <dbReference type="OMA" id="ALDQCWD"/>
    <dbReference type="OrthoDB" id="2024964at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020311">
        <property type="entry name" value="Uncharacterised_Rv0898c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10944">
        <property type="entry name" value="DUF2630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="82" mass="9444" checksum="50B53EFC1207661A" modified="2011-06-28" version="1">MDDKTILSRISELVDEEHRLRADAQATEAGTDDEARTRLRELEASLDQCWDLLRRRRAARQAHGDPEAQGARPVSEVERYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFS7</accession>
    <name>F4FFS7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736187.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02350"/>
    <dbReference type="EnsemblBacteria" id="AEB47554">
        <property type="protein sequence ID" value="AEB47554"/>
        <property type="gene ID" value="VAB18032_02350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02350"/>
    <dbReference type="eggNOG" id="ENOG5032K8N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1600828_0_0_11"/>
    <dbReference type="OMA" id="WPMSVKT"/>
    <dbReference type="OrthoDB" id="2070294at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="159" mass="16515" checksum="55052AE545FE6974" modified="2011-06-28" version="1">MRGGLDETLARMRRREEALRLRSTEPADGESGSADGTPPSGAGGRNDGTGWAPPREAGGHVLDDVAEALRAAVAVHPGTAVTARIDHDGQAYDLRVAWTGQEVTVTGQPVAAPPSWPLSANTVAGWPARQESLTGDPAARLAELIRRDPSLLTSEGPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG76</accession>
    <name>F4FG76_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13540"/>
    <dbReference type="EnsemblBacteria" id="AEB43820">
        <property type="protein sequence ID" value="AEB43820"/>
        <property type="gene ID" value="VAB18032_13540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13540"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_1_1_11"/>
    <dbReference type="OMA" id="NSCLMHI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="27776" checksum="9EA800E095F16BA3" modified="2011-06-28" version="1">MRIALFVTCLADTVFPEAAKATVRLLERLGHEVVFPTEQTCCGQMHVNTGYQREALPLIRRHVRTFDPYDVIVAPSGSCVGSVRHQHPLVARRAGDDRLAGRAEDVAARTYELSELLVDVLGVTDVGAYYPHRVTYHPTCHSLRMLRVGDRPLRLLRAVRGLDLVELPDAEQCCGFGGTFAMKNADTSTAMLADKMRHVLSTGADVCTASDSSCLMHLGGGLSRLRTGVRTVHLAEILASTERSATAGERVAVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGG6</accession>
    <name>F4FGG6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733759.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20010"/>
    <dbReference type="EnsemblBacteria" id="AEB45104">
        <property type="protein sequence ID" value="AEB45104"/>
        <property type="gene ID" value="VAB18032_20010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20010"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_8_11"/>
    <dbReference type="OMA" id="ITVERIM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="201"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="389" mass="41389" checksum="E80BBC54E487D83D" modified="2011-06-28" version="1">MTSGTVQSITPAAGAGSPAAGQVRRARAVVVTRTVAYVFTVVMLAFGLLPIVTAVTEGRSWWVVTVGAGGFAVVATAFIRLVTHAMRHPWSNRRRDDALLVTGIVLLLPVLVDRNWQVIGFLALAAVAVTFRPRYGLLLAVGVLVLITVERIMLDTPGVVFLTVQDVLTGAALAGIIVLVAFIEELFAARAEVARLAVDAERVRFARDLHDTLGHNLSAIALKSELALRLLDRDSARARSELNDVYGIARDSLRDVRTVVKGYRRDSLQRELEGVQSVLVAAGVRCEVATPVEALPAPVEEVLAWAVREAATNLLRHSSASRCRISMHRSDDQVRLDVANDGAASPAPTDDIGGSGLTGLAERLAPLGGTLTAGHRAGGEFVLTVLVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGL6</accession>
    <name>F4FGL6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_26265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26265"/>
    <dbReference type="EnsemblBacteria" id="AEB46351">
        <property type="protein sequence ID" value="AEB46351"/>
        <property type="gene ID" value="VAB18032_26265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26265"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_11"/>
    <dbReference type="OMA" id="NMGWFLI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="298" mass="31118" checksum="C3DDB1A027D7960F" modified="2011-06-28" version="1">MGAIYALVALGYTLVYGVLRLINFAHSEVFIAGAFAAIWGWAALGLDRDSVASGFGSIILYLLVGALIAAVASAGTATVVERVAYRPLRKRNAPPLAFLITAIGASIAIAEAFGIYTRRLPVGAPTIVKPDLVLFEVAGTEVTVVQVLVIVSALAMMVALDLFINRSRIGRGIRAVAQDQNTAALMGINKDRIILVVFIIGGVMAGVAGMLYDIRIGTLTYSVGFLLGLKAFTAAVLGGIGNLRGALVGGLLLGLVENYASALFGANWKDLVAFVVLVVLLMFRPTGLLGESLGRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGN1</accession>
    <name>F4FGN1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735017.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26340"/>
    <dbReference type="EnsemblBacteria" id="AEB46366">
        <property type="protein sequence ID" value="AEB46366"/>
        <property type="gene ID" value="VAB18032_26340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26340"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="OMA" id="GYGTMQL"/>
    <dbReference type="OrthoDB" id="1367386at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="26"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="31431" checksum="B04BF77F682EF855" modified="2011-06-28" version="1">MASNADTRPAKASGTYRIGGDLTVDRLGYGAMQITGPGVWGDPKDPAEAVRVLRRAYELGVTFIDTADSYGPFVSELLIKEALHPYADDLLIATKAGLSRSGPGDWRPLGRPEYLRQQCELSLRHLGLESIGLYQLHRIDAKVPLADQLGELVLLKEEGKIRHIGLSEVTVEQIEAARQIAPIASVQNLYNLVNRKAEDVVTYCENNDIAFIPWYPIATGELARPGGPLDAISTEHGATPAQLALAWLLRRSPVMLPIPGTSSVAHLEENVAAAQVTLTDTEYETLSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGR2</accession>
    <name>F4FGR2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02440"/>
    <dbReference type="EnsemblBacteria" id="AEB47572">
        <property type="protein sequence ID" value="AEB47572"/>
        <property type="gene ID" value="VAB18032_02440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02440"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_11"/>
    <dbReference type="OMA" id="RPPRFTW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="27048" checksum="41E91C2B53163741" modified="2011-06-28" version="1">MADAELTVAVSGQVATVVIRNPGRRNAMTLAMWRQLPVLLDHLEAEPAVRALVLTGADGTFCAGADLGDLDEQLSTGDAGIAVAAEERLAAFAKPTVAAVRGACVGGGCQLAVACDLRITADDARFGVPPARLGLVYPAPTTRRLARLVGPAAAKHLLFTSELIDAERAQRIGLVDEVLPGDRLAARIDQLTGMIVERSQLSVVAAKEIIDGRADDARVDWWYGQVRASGEAREGITAFHERRPPRFTWSPPPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGU0</accession>
    <name>F4FGU0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_02580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02580"/>
    <dbReference type="EnsemblBacteria" id="AEB47600">
        <property type="protein sequence ID" value="AEB47600"/>
        <property type="gene ID" value="VAB18032_02580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02580"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026207_2_1_11"/>
    <dbReference type="OMA" id="YWTAAQQ"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="9">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="119"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="42798" checksum="AE2784F4E378AD1F" modified="2011-06-28" version="1">MSERVSWVAGAEGSGFGIQHLPYGVFRVGDGEPRIGVRIADVVLDLAAAEAAGLVLAGGALREPTLNTFLALGRPQWTAVRQRITELLTDPAHRAAVEPLLVSLEQVRMELPIEVADYVDFYSSEQHASNVGQIFRPGQPALLPNWKHLPIGYHGRAGTVVVSGTPVVRPQGQRPSNDGPVFGPSVRLDIEAEVGFVVGVPSPLGARVAVADFAEHVFGVVLVNDWSARDIQAWEYQPLGPFLGKSFATSIAAWVTPLDALRSAYVAAPEQDPSVLDYLRDEPHVGLDLRLTVHWNGETVSEPPFAGMYWTPAQQLAHLTVNGAALRTGDLYASGTVSGDRRDQVGSFLELTWGGAEPVTVGGAERTFLLDGDTVTITATAPGPDGSTITLAEVTGTIVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGV8</accession>
    <name>F4FGV8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid-binding act domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736250.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02670"/>
    <dbReference type="EnsemblBacteria" id="AEB47618">
        <property type="protein sequence ID" value="AEB47618"/>
        <property type="gene ID" value="VAB18032_02670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02670"/>
    <dbReference type="eggNOG" id="COG2716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095322_1_1_11"/>
    <dbReference type="OMA" id="SCTMLGG"/>
    <dbReference type="OrthoDB" id="1859752at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="170" mass="17526" checksum="C448C9F519C0EFA6" modified="2011-06-28" version="1">MNELAITVIGRDRPGIVADVAEVLARLGANLTDSTMTRLRGHFAMTLICVGPSAAEVEDALGPLTADGQLLATVRQVRPDGETVPTGERYVMSVHGADRMGIVAAMTRAVTVAGGNVTDLSTRLVGSLYVVVAEVDLPADVTGTLPGQLAEVAAGLGVEVTLRPADPDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH20</accession>
    <name>F4FH20_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731307.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07570"/>
    <dbReference type="EnsemblBacteria" id="AEB42634">
        <property type="protein sequence ID" value="AEB42634"/>
        <property type="gene ID" value="VAB18032_07570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07570"/>
    <dbReference type="eggNOG" id="ENOG5030M0S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917693_0_0_11"/>
    <dbReference type="OMA" id="YKVSELC"/>
    <dbReference type="OrthoDB" id="2133891at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="31073" checksum="A12EEB1FBDAE3150" modified="2011-06-28" version="1">MASTPTDKTTGTATPPQPAPSVAKVLAALHRLGEATAAAIATEAGLGYSTTTPKLRSLETAGLAEPTRSDTGRSLWRLTDTGRAQVEEADDHSQPEGQDAPNAAADAPQGTHGDDTQNTGQDHDQRQAVADPTDPPVTASESESPAAGDVETAPDEATLPETTDDSRPRAEPEVPAAADHTDPPAGAPTADEPADTPADGLTDDTTGDPTAEGTSSASAGQVAGGPPGTRRASGTLRGAILDILEANPGKQYKVSELCKLIDRANEGTDAKKASAGAVHNAAVKLVGTGRAVMAAEKPATFALTDPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH29</accession>
    <name>F4FH29_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA containing CoxE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731316.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07615"/>
    <dbReference type="EnsemblBacteria" id="AEB42643">
        <property type="protein sequence ID" value="AEB42643"/>
        <property type="gene ID" value="VAB18032_07615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07615"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465925_0_0_11"/>
    <dbReference type="OMA" id="HAAHSVW"/>
    <dbReference type="OrthoDB" id="1571905at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="543" mass="59671" checksum="7BB359678B354AC2" modified="2011-06-28" version="1">MSQTHLRPGTPPTRSGVNDWQAWSQAWTQHVPLLTGRTDLTVLVAPGAAGDAPECFYPDLHRIEVDATYIADRPDITDPTKARHKRLVPTGYGLLVHGAAHAAHSRWTTPPGTPPILADVAAMLEESRAEGRQRTRRRGDRRWLRHVVKTLLDPDDAAVDDPWHAGQLAALLLARVDARIVTSKDVRPVRAAVTGLLGRKRLRHLRDIWREAHTCDDTDADTMITLARRWCHILGIDPDHQHATPVPDAGQFPGRLAAALVDYLAAASGLTPTEYTASQLAHRHSPPSEWARRDPTEQERHAARDLANRLQQARTRHPEPGRRPSTIPPGRLRTRHAITADAQTAAGQLPTAAPWQQRTHLPPEKPRLHLAILVDLSGSMGRYTEPMSSAAWIFAHAARRAHAVTTTIGFGDRTTILVPPRTSPTQVLHMRTDVATATFPEAVKVADQLLDLRHGRTLRMLAVVSDGYLDDIPAGQRLVTTLHRAGCAVLWLHPADPPTPGQPTEPDQRWGHTFTHTTTLTVTDPVHAVTAIADAAVTALEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH82</accession>
    <name>F4FH82_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13740"/>
    <dbReference type="EnsemblBacteria" id="AEB43860">
        <property type="protein sequence ID" value="AEB43860"/>
        <property type="gene ID" value="VAB18032_13740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13740"/>
    <dbReference type="eggNOG" id="COG3980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023406_0_0_11"/>
    <dbReference type="OMA" id="DHRQPDP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="31902" checksum="8006A52198CEBFA4" modified="2011-06-28" version="1">MFGTVAGVGWAADQLAARGIPLRPGPETPEELVETVRRHEVDVLVLDSYELDPAAAGAVRAAGVVTLAIVDGDTRGQDADLYLDQNFDTDLVVPAGRLLAGSAYALLRGEVLAARPTAARPAVPVDRPTVLAFFGGTDAAGAAPLLTEMLLSTGRPMALTVVAGRPELADRLARLAPAPGQTLTVLPPTGRLPALIAAADLVVSAAGTSTWELCCLGAPSALVCVVDNQRESYHRVVSAGLAAGLGDLPTLVVDPSARAAAARTLDSLLGSAERRAALSQRAWSAVDGRGRARVVDAVLDTLDSSVERLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHD9</accession>
    <name>F4FHD9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SagB-type dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733766.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20045"/>
    <dbReference type="EnsemblBacteria" id="AEB45111">
        <property type="protein sequence ID" value="AEB45111"/>
        <property type="gene ID" value="VAB18032_20045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20045"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044684_0_0_11"/>
    <dbReference type="OMA" id="WFHRRST"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="284"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="520" mass="56377" checksum="6F989A8B00771342" modified="2011-06-28" version="1">MTLTQSTRPYERLLRLDPSSRLTSGGGQLALWSRFGRVAVGERDRPMVAVLQALATTEVTPTDLERLALATAGATATDDEIAVLARLHWLLDRIGNALEQQIGPAGEPGWLRVTALTGDLRFTHRPYTGNAPVALSRLALLRRRDGRMVVESGLAPFRVGVLHEQALALVGALAEPRTVADLAARLGLDETAIRHLVGFLAAAQLTDAVDPAADQWDPHELYFHSRSRCGRTDESFGATFPFVDVRPPLPPVKPAPAGPVVVLPRPDFDALRATDPPLVLVQEARRSVRGFGVEPMTLAQLGEFLYRVGRVRSVYGPDHDNRMPYEGVDRPYPTGGASGDLEIYVTAHRVAGLPRAAYHYDAWEHRLVQVCDDPTLIQGLLAGAAQATGGTPTPDALITFTSRFGRLTWKYDAMGYAATLKHVGVAYQTAYLVATAMGLAPCGLGSGDAHLSARVFGLDWQVESSVGEFMLGSLPRWADGTDPHQGRTNWRGANDPDWARRAGRLLSAARHDRVAPEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHJ1</accession>
    <name>F4FHJ1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20315"/>
    <dbReference type="EnsemblBacteria" id="AEB45163">
        <property type="protein sequence ID" value="AEB45163"/>
        <property type="gene ID" value="VAB18032_20315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20315"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_1_3_11"/>
    <dbReference type="OMA" id="WRVDLIP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="32708" checksum="0704DFF2B97EA3EA" modified="2011-06-28" version="1">MAQQTPIMLVDAPSLYFRAYFGIPESAAKTADGQPVNAVRGFLDMLAQLVRTRRPGRMVCAMDHDWRPDWRVALLPSYKAHRVAPEGGEIVPDTLSPQVPMLLDVLEALGITVVGAAGYEADDVLGTLSVTQPGPVEVVSGDRDLFQLIDDARAVRLLYIGRGVAKLDDCDDAAVRARYGVPADRYAEFAALRGDPSDGLPGVAGVGEKTAARLIDRYGDIAGILAALDDPASGFAPGLRAKLAAARDYLAVAPKVVRVALDVPLPPLPTELPTAPADPDRLLDLAQRWNLAGSTRRLVDALATGADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHM3</accession>
    <name>F4FHM3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="5">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">trpA</name>
        <name evidence="7" type="ordered locus">VAB18032_26576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735043.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26576"/>
    <dbReference type="EnsemblBacteria" id="AEB46392">
        <property type="protein sequence ID" value="AEB46392"/>
        <property type="gene ID" value="VAB18032_26576"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26576"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_0_11"/>
    <dbReference type="OMA" id="IGCMPAG"/>
    <dbReference type="OrthoDB" id="912786at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="28076" checksum="375C81B06E3702D3" modified="2011-06-28" version="1">MSEQQSRIGVVFDKARAEGRAVLIGCMPAGFPTVEGSITAMKAMVAAGVDVIELEIPYSDPVMDGPVIQRASDIALAGGVRTRDALRIIEEVTATGAPVVTMTYWNPIEQYGVDAFARDLASAGGTGLITPDLIPEEAGEWLAASDAHGLDRTFLVAPSSTDERLAMTVEHCRGFVYATALMGVTGARTQTSEAAPVLVSRVRKVTDLPVGVGLGVGTGAQAATVAGYADGVIVGSALIRCLLDTPDEPTALTALTTLTTALATGVRHPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHN8</accession>
    <name>F4FHN8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26671"/>
    <dbReference type="EnsemblBacteria" id="AEB46407">
        <property type="protein sequence ID" value="AEB46407"/>
        <property type="gene ID" value="VAB18032_26671"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26671"/>
    <dbReference type="eggNOG" id="COG2364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083843_0_0_11"/>
    <dbReference type="OMA" id="APWDVLH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="22723" checksum="C3BD99AEE1DAC61A" modified="2011-06-28" version="1">MLIGNLRHRPVRRLVQLFGGLLLYGASMALMVRSELGLNPWDVFHQGVSRLTGLSMGTVVIAVGLLVLLAWIPLRQRPGIGTLANAVVVGLAVDLTLALLPPVEPLAAQIALLTAGIVGNGMATALYLGARLGPGPRDGLMTGFTARRPGRSLRLVRTVMEVVVLAVGALLGGKLGVGTIAYALAIGPLAQFFLPRFDVPEPHPGTTTPRIETAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHS4</accession>
    <name>F4FHS4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ordered locus">VAB18032_26851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735094.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26851"/>
    <dbReference type="EnsemblBacteria" id="AEB46443">
        <property type="protein sequence ID" value="AEB46443"/>
        <property type="gene ID" value="VAB18032_26851"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26851"/>
    <dbReference type="eggNOG" id="COG3442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064047_2_0_11"/>
    <dbReference type="OMA" id="GTYMHGP"/>
    <dbReference type="OrthoDB" id="1527083at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="240" mass="25318" checksum="21A410B76CB25C98" modified="2011-06-28" version="1">MSTETLRIVWIYPDLLSTYGDRGNALILARRARQRGFPVEVLEVRSDQPLPTTADIYLIGGGEDGPQALGAQRLLADGGLHRAVAQGSVVFGVCAGYQLLGTSFFAKGTQYRGLELLDLSSDRGASRAVGELAGDIDARLGLPPLTGFENHGGRTQLGPGVSPLARVTAGVGNDGATEGAWRGKLLGTYSHGPALARNPALADLLLRWATGAQQLPPLDDTWADRLRAERRTAVAAAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHX0</accession>
    <name>F4FHX0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">VAB18032_02895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736295.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02895"/>
    <dbReference type="EnsemblBacteria" id="AEB47663">
        <property type="protein sequence ID" value="AEB47663"/>
        <property type="gene ID" value="VAB18032_02895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02895"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_1_11"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="OrthoDB" id="1767807at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="168" mass="19226" checksum="FE16F8A48FC7F019" modified="2011-06-28" version="1">MDFDVTVEIPKGHRNKYEVDHVTGRIRLDRTLFTSTQYPADYGFIEGTLGEDGDPLDALVLVPEPTFPGCLIRCRTIGMFRMTDEKGGDDKVLCVPYEDPRQEHLRDIHHLGEFDRLEIQHFFEVYKDLEPGKSVEGATWVGRTEAEAEIQASYRRAREAAERGESTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI47</accession>
    <name>F4FI47_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_30239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
            <plasmid evidence="3 4">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713133.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB48011">
        <property type="protein sequence ID" value="AEB48011"/>
        <property type="gene ID" value="VAB18032_30239"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30239"/>
    <dbReference type="HOGENOM" id="CLU_645491_0_0_11"/>
    <dbReference type="OrthoDB" id="891684at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB48011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="425" mass="47102" checksum="114A308A8DF25CD1" modified="2011-06-28" version="1">MSTGHRRAVTRRNTRPYVVDESTIRQRCTNPDAAEYTLYVRSLIDDYLGVGGQAQVIRIARMRRLDFPGLSRQKLSEQLSRYRLGPTWEMTELIIACLPDTCDTDSIRALAAGWYQCARGNLPDGYKGPVSRPPGKPGMRNVPESEPSVQVLQRKLARLQERLKDETARYLNNLRASENGRNHELRRANQLEAQFHQTRQELFQARAVAAEVATIREEYARQCVTLELIAAPGLRSKPIIDLPKPSAGRDRIRFGLLVATIDPQAPAVRRALARYLCVYAEFAGASPTELASRADIAATLMMDILAGRLVPTTDHRTRLSAVLDCDPETLRHLTTAASSATALDECFWSIAGTVDALVTPDALHSDNGVVGSDPDNRFSHPHTDPTAAPPGSVPDRLRQLATVHREGLISDGEYAEQRARILAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI71</accession>
    <name>F4FI71_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Resolvase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_30359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AB-18-032</strain>
            <plasmid evidence="4 5">pVMKU</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713157.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30359"/>
    <dbReference type="EnsemblBacteria" id="AEB48035">
        <property type="protein sequence ID" value="AEB48035"/>
        <property type="gene ID" value="VAB18032_30359"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30359"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_8_0_11"/>
    <dbReference type="OMA" id="MALKMYD"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="3">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB48035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="24590" checksum="8DC996191AC424F4" modified="2011-06-28" version="1">MDGVTVTPAPTEGDLLLPTPLAGVLVGYGRVSTREQNLARQQAALTAAGCAKCFFDKASGKNADRPELTKVFEYIRPGDALTVVSLDRLGRSLEDLIGIVGRLKRHGVGFQSLHEKLDTTTPGGMFVFHVFAALAEFIRTIIVANTNEGLAAARAAGQRLGRPPAMTPEKVAYALQLLSEPDRTMTSIAKLLGVSRSTLYTALPELQAAKRAGGGPDDVLAQRQPDSRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1C8</accession>
    <name>F4F1C8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732631.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14260"/>
    <dbReference type="EnsemblBacteria" id="AEB43964">
        <property type="protein sequence ID" value="AEB43964"/>
        <property type="gene ID" value="VAB18032_14260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14260"/>
    <dbReference type="eggNOG" id="COG3380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036034_0_0_11"/>
    <dbReference type="OMA" id="CIFDPRG"/>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="319" mass="33958" checksum="7C6302D2D13824CD" modified="2011-06-28" version="1">MTTERTGVVVVGAGIAGVACAVQLQRAGVPVQLRERAQVAGGRMASKRFDGRPADLGAAYFTVSDPDFAEVVAQWQAAGLVREWTDTFVAYGAQGRHEVRGPMRWAAPGGLRSLVEHLSQDLPVLVNRLVLDVAPGPSVDGQRCQAAVLAMPGPQAALVLDPALTAATEALRNQRWSPSLAAMLRFPHRRWPDFRGAFVNDHPVLRLVCDDGDRRGDREPVLVAHTTAHFAAGHLAQPTAAAPAVEAAVRDLLALPEPAVHVHLHRWTYAQPTAGSAAGFHLDDEGIGLAGDAYGAPPRVQTAWRSGHDLGRALASRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Q2</accession>
    <name>F4F1Q2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735128.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27021"/>
    <dbReference type="EnsemblBacteria" id="AEB46477">
        <property type="protein sequence ID" value="AEB46477"/>
        <property type="gene ID" value="VAB18032_27021"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27021"/>
    <dbReference type="HOGENOM" id="CLU_1218640_0_0_11"/>
    <dbReference type="OrthoDB" id="2130063at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="26054" checksum="28AE1C832E23F58D" modified="2011-06-28" version="1">MSVPYLRRVALVALFVLLLVSLVGRTVFMLWEPPFDGTIRYDDIRELGSAYWPMNLYLGGPAYAVSWVAAAVFIVRLGRGRAGLLNLVGAFLVGLGGVVFALTITAEVLPFAYAADPAVLPEAQGRALFDVLNDRLDWVIPAIIGSQLAIVVGMLLALVGALIARTMPRPLTIAALVYAVLFVALPLAQFGRAVVIVDYLLQVALVAAIGWYGLRAVDREARDSATPAVDDRSTAAPHTDPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1U4</accession>
    <name>F4F1U4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase caa3-type, assembly factor ctag-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_27231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27231"/>
    <dbReference type="EnsemblBacteria" id="AEB46519">
        <property type="protein sequence ID" value="AEB46519"/>
        <property type="gene ID" value="VAB18032_27231"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27231"/>
    <dbReference type="eggNOG" id="COG3336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054944_1_0_11"/>
    <dbReference type="OMA" id="CVFFWPL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="35696" checksum="78322D324E685C42" modified="2011-06-28" version="1">MLHVDPIFLAAPAAPQLTAGLPGPGGASVLAAEGALPPFSVTTVVTEARLDNWLAVVLVLAAGLYLYGVNRLRVRGDRWPVARTVFFLGPGLGGIASVTLTGLGAYDTTLLSVHMVQHMVLSMVSPIFLALGAPVTLALRTLPPSPRKRLLAVVHSRIARIYSFPLVAFAIFVVNPFALYFTDLYRYTLEHGWAHELVHAHFIMTGCVFFWPLLGLDPLPGRWPHPARALLMLLSVPFHTVLGLTIMQSSTLFGGDWYPSLGLSWADPREDQVLAGGILWAGGEFVSVTMLAVLVVQWMRHAEREARRVDRELDRQEARQRAAEATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1V2</accession>
    <name>F4F1V2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46527">
        <property type="protein sequence ID" value="AEB46527"/>
        <property type="gene ID" value="VAB18032_27271"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27271"/>
    <dbReference type="HOGENOM" id="CLU_3105119_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="51" mass="5411" checksum="3D08F78CA60C37CE" modified="2011-06-28" version="1">MRWSTAGEPVSVAAPSAASTVLPEGASYETVVDTRAVTVYTDLHDQRASRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F213</accession>
    <name>F4F213_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo-1,3(4)-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_03380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736392.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03380"/>
    <dbReference type="EnsemblBacteria" id="AEB47760">
        <property type="protein sequence ID" value="AEB47760"/>
        <property type="gene ID" value="VAB18032_03380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03380"/>
    <dbReference type="eggNOG" id="COG5498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005482_1_0_11"/>
    <dbReference type="OMA" id="DTYWTGK"/>
    <dbReference type="OrthoDB" id="386120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="PTHR31983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307598" evidence="2">
        <location>
            <begin position="38"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro81C" evidence="3">
        <location>
            <begin position="394"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="972" mass="103296" checksum="0710906E65139883" modified="2011-06-28" version="1">MRPPVPHRTHHRLLAAGAAAALVLGGLAVIATSAAQAAPVGAGSYTTTPVGPLPSGCGNLTTNPRQYVTAAAPAGPVPTNDWWSSLLWKRFNCAFSEPLHAHPVAYQPVTDGLGFSATSTATITGTATGVGEFKYPYVEDIRVGLAGLGAPNVLVDDWTDWTVTPYWSDGSRTLRATIGHGLPFTYFRSTGGDAVINATGGSPTIWSNSGATIGFTVRGHDYVAYAPSGATWTVSGARISSNLAGRGYFSVALLPATADGTTRAQLATTYGRYAHAHVTGTRVAYSYQQSSSQVETRYTFTTTPREGTETRTVVSLYPHQWKALTGATPISQTYPSARGRMKVLTGVAEFRTSMRFHGVLPEVPAVATGAGTDLTTLRQHLAATRANPMDQRGGDTYWTGKGLGRAARIAEIADQVGDTETRTAALNAIRATLTDWLTASPGETERLFYYDQRWGTLIGYPASYGSDQELNDHHFHYGYYIAAAATLAKFDPAWARQDQYGGMIDLLIRDANNYDRTDSRFPYLRDFDIYAGHDWAAGHGAFASGNNQESSSEGMNFANALIQWGQATGNTAVRDAGIFIYTTQAAAIHEYWFDVTGENFPAAFGHNNVGMVWGDGGAYATWFSAEPEMIQGINLLPITGGHLYLGYHPDYNAQKYAELVRNNGGEPTIWQDMHWQFLALGDADAALAKLRANPGYTPEEGESRAHTFHWVRNLAALGRVDTEITANHPLAAVFNRNGARTYVASNISNTQLTVRFSDGTQLSVAPGRTATSGAHTWSGGSGGGGTPPPTTTPTPTPTPTPTPTPTPTPTPTPTGPVSSPVRYLLSGGGLGAAGSAGSTTVTSAGGGNYDGTPRNPVVFTATGLNLNHNGGQTAFDLLLDAGQAVGNGVQLRISYDLTGNGSWERIETYRYFATDPVPGWEHYTQAAGLHSSTGSLGNLRNGTVRVEVWSAIGNNPSTLGIGNQSVIRLPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F242</accession>
    <name>F4F242_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731404.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08065"/>
    <dbReference type="EnsemblBacteria" id="AEB42731">
        <property type="protein sequence ID" value="AEB42731"/>
        <property type="gene ID" value="VAB18032_08065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08065"/>
    <dbReference type="eggNOG" id="COG2818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083758_0_0_11"/>
    <dbReference type="OMA" id="YVAYHDT"/>
    <dbReference type="OrthoDB" id="1835478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="21135" checksum="A34BC6E8CA503C6D" modified="2011-06-28" version="1">MTDLVIGDDGLPRCPWGAGTADYVVYHDEEWGRPVRGDDALYERMTLEAFQSGLSWLTILRKRQAFRRAFDDFRISAVAGYGEADVARLLADTGIVRNRAKIEAAIANARAALELPEGLSELLWSFAPPNRPRPASFAEVPALTDASTAMAKALKRRGFRFVGPTTAYALMQATGMVDDHVAGCHVVPPGAAVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F264</accession>
    <name>F4F264_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_08175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731425.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08175"/>
    <dbReference type="EnsemblBacteria" id="AEB42753">
        <property type="protein sequence ID" value="AEB42753"/>
        <property type="gene ID" value="VAB18032_08175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08175"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_1_0_11"/>
    <dbReference type="OMA" id="GNTDCYQ"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="63"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="347" mass="38488" checksum="AA5C01BFDBB31879" modified="2011-06-28" version="1">MRWENLTAPPVEGVPGRAAPATPPLPLALPGAVVRTFDTPGFAGMTFYEVHARSILNKVPGTSRVPFEWTVNPYRGCSHACLYCFARKTHTYLDFDAGADFDRQVIVKVNAGELLRRELAAPRWRGAHVAMGTNVDCYQRAEGRYRLMPSIIEALRDFANPFSILTKGTLIVRDLPLLRQAAQATRVGVSFSVGFVDERLWRSVEPGTPSPQRRLDAVRQFTDAGFEVGVLMAPILPGLSDDDESIESTVAAIAAAGAASVTPLPLHLRPGAREWYAQWLAREHPHLVPRYRELYRSGAYAPQPYQRELTARVRVAARRHGLYRPDRSEHRQVPAAPAPAPEQLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2A4</accession>
    <name>F4F2A4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08375"/>
    <dbReference type="EnsemblBacteria" id="AEB42793">
        <property type="protein sequence ID" value="AEB42793"/>
        <property type="gene ID" value="VAB18032_08375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08375"/>
    <dbReference type="HOGENOM" id="CLU_2037086_0_0_11"/>
    <dbReference type="OMA" id="WSICLAV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046151">
        <property type="entry name" value="DUF6153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19650">
        <property type="entry name" value="DUF6153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="11875" checksum="35DA6E3CD1EF4D90" modified="2011-06-28" version="1">MLACTLFGLATMHSLGHDPMIGAAGHGSYAETAAACADGHCTPLAAPASEAPGHGGGGGWAVCLAITAGFALTVVLAALLLRGTRGVRPRGRTPTPPAGGRAPPVFVPIGLTTAVVSVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2J6</accession>
    <name>F4F2J6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase s1 and s6 chymotrypsin/hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_14780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14780"/>
    <dbReference type="EnsemblBacteria" id="AEB44068">
        <property type="protein sequence ID" value="AEB44068"/>
        <property type="gene ID" value="VAB18032_14780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14780"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030648_2_0_11"/>
    <dbReference type="OMA" id="IYASSWR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307349" evidence="7">
        <location>
            <begin position="27"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="8">
        <location>
            <begin position="83"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="344" mass="34532" checksum="04A6ABD424BF77FC" modified="2011-06-28" version="1">MLRRAVTVAAAGTLVAGVLAGTPAQAAPASATPDSAAALAERLGARAAGAYADAAGKMVVAVTDSLAARQVASAGATPKLVKRGAAELNRATAELDRSAAIPGTAWWVDPATNQVVVSVDSTVTGAKLERVKAAAARTNGAVRIEAEAGVLSTRISGGEAIYAQGGGRCSLGFNVRAGSTYYFITAGHCTNIAANWYSNSSQTSLLGSRTGSVFPGSDYGIVRYSNQSVVQPGNVSLYNGTFRDITASGNAYVGQSAQRSGSTTGVRSGSVTALNATVNYAEGQVRGLIRTNICAQPGDSGGSLFSGTIALGLTSGGSGNCSIGGTTYFQPVGPVLSRYGVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2S4</accession>
    <name>F4F2S4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733993.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21195"/>
    <dbReference type="EnsemblBacteria" id="AEB45339">
        <property type="protein sequence ID" value="AEB45339"/>
        <property type="gene ID" value="VAB18032_21195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21195"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_11"/>
    <dbReference type="OMA" id="PRWCFLK"/>
    <dbReference type="OrthoDB" id="1825548at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="126"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="382" mass="41884" checksum="CC55889643654DCC" modified="2011-06-28" version="1">MTTISRVETFLVAPRWLFVRVETTDGIVGWGEATCEGRSETVRTAVEQLSELLIGQDALRIEDHWQVMTKGSFYRGGPILASAVAGLDQALWDIAGKRYGAPVHQLLGGPVRDRIRVYGWVGGDEPSEVRDQIAARVEAGLTAVKMNASGRMSPLATVAELDEVVQRVAAAREVLGEHRDVAVDFHGRFTLANARRVAPLLEPYRPFFLEEPVVPENSHLIGEFVRSTTTPVSTGERLYNRQEFLPVLQAGIAVAQPDLSHAGGITEVRKIAALAETFDVQLAPHCPLGPIALAACLQVGFATPNYLIQEQSIGIHYNLGAEVLDYCVDQQPLTFVDGYVQRLTAPGLGIEIDEQAVRAADKRGHAWRSPMFRHVDGSYAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2U0</accession>
    <name>F4F2U0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">VAB18032_27391</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735201.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27391"/>
    <dbReference type="EnsemblBacteria" id="AEB46551">
        <property type="protein sequence ID" value="AEB46551"/>
        <property type="gene ID" value="VAB18032_27391"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27391"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_2_11"/>
    <dbReference type="OMA" id="HMVGDRM"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="9"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="342"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB46551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="463" mass="48754" checksum="B2504854015A998A" modified="2011-06-28" version="1">MSEPNDATFDIVILGGGSGGYATALRAAQLGLSVALVEKGKLGGTCLHNGCIPTKALLHAAEIADQTRESEQFGVKAELVGIDMAAVNSYKDGVISRLYKGLQGLVTGNKAITFVAGAGKLVAPNVVEVDGKRYTGRNIVLASGSYAKSLPGLEVDGERVITSDHALVLDRVPGSAIVLGGGVIGVEFASVWKSFGVDVTIIEALPRLVAAEDEESSKALERAFRKRKINFKVGKPFEKVETTDSGVKVTIAGGETVEAELLLVAVGRGPNTANLGYEEQGVKMDRGYVLTDERLRTSVPNVYAVGDIVPGLQLAHRGFQQGIFVAEQIAGQNPAVIDEAGIPRVTYCDPELASVGLTEAKAKEQYGADKIKTYNYNLGGNGKSQILKTTGFVKLVRVEDGPVVGVHMVGARVGELIGEAQLIYNWEAYPGEVAQLVHAHPTQNEALGEAHLALAGKPLHAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3B4</accession>
    <name>F4F3B4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731509.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08600"/>
    <dbReference type="EnsemblBacteria" id="AEB42838">
        <property type="protein sequence ID" value="AEB42838"/>
        <property type="gene ID" value="VAB18032_08600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08600"/>
    <dbReference type="eggNOG" id="ENOG5032ZIA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145468_1_0_11"/>
    <dbReference type="OMA" id="FGAWVVE"/>
    <dbReference type="OrthoDB" id="1889547at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12302" checksum="603EA2060B3BAB6E" modified="2011-06-28" version="1">MEALRLILLYVHLIGFALLLGGAIAQYISGKLRINAAMLWGAVIQLLSGTGLAAPLRDGDEPDPAKLVVKFLIALAIFVMVFFSRKRDEVNRGHFLAIVGLTLVNAAVAVFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3H4</accession>
    <name>F4F3H4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_14850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732749.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14850"/>
    <dbReference type="EnsemblBacteria" id="AEB44082">
        <property type="protein sequence ID" value="AEB44082"/>
        <property type="gene ID" value="VAB18032_14850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14850"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_0_1_11"/>
    <dbReference type="OMA" id="PMGWTAQ"/>
    <dbReference type="OrthoDB" id="2075502at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="16438" checksum="DE002DCE94B34DF2" modified="2011-06-28" version="1">MTELSRGVRLGVDVGQVRIGVSRSDPHGVLATPLVTVAREQKPRPDAVPKDLVEIAALVVEHEAVEVVVGLPVNLAGRHGPAAEHVKAYARQLAEVIAPVPVTLTDERMSTVVASRRLAERGVRGKKQRAVVDQAAAVEILQSWLDTQRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3U4</accession>
    <name>F4F3U4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21475"/>
    <dbReference type="EnsemblBacteria" id="AEB45395">
        <property type="protein sequence ID" value="AEB45395"/>
        <property type="gene ID" value="VAB18032_21475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21475"/>
    <dbReference type="eggNOG" id="COG1540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058821_2_1_11"/>
    <dbReference type="OMA" id="HDEMIET"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="170" mass="17147" checksum="95091155A75362A6" modified="2011-06-28" version="1">MYVSALAGTGAAVGGTAAAPGVGTAVALALSAGEALSSLELSALFALSIAEVHGVPIDEIERRRTIVMGIMLGGSGSATITKVAERTGQHWGRQVVAKVPAETLRQINKILGRHFITKYGAKQGIVVLGRVAPFGIGAVIGGGANAAMATLAVKAARRAFGPPPTSWPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F414</accession>
    <name>F4F414_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fad linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735310.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27936"/>
    <dbReference type="EnsemblBacteria" id="AEB46660">
        <property type="protein sequence ID" value="AEB46660"/>
        <property type="gene ID" value="VAB18032_27936"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27936"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003896_4_2_11"/>
    <dbReference type="OMA" id="HWGKVFT"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="411" mass="44437" checksum="CDCF8E47B07D306B" modified="2011-06-28" version="1">MPTHRNWAGNIQYSARAYHRPTTVAELATLVAGSDRIRAVGSGHSFNPLGDTTGDLVTLAGLPADVRLDEERRTVDVPAAMRYGDLASWLHERGYGLANLASLPHISVAGAIATGTHGSGERNGNLATAVAGLELVTATGELRTVHRDSDDFAAMVVSLGALGIVTRVTLDVLPTFDLRQYVHLDLPRAALDEALGSAYSVSVFTDWRSTRGTQVWRKQLADAPAPPAGWLGTTAADRPWHPVPGMPTANCTEQLGVPGPWHERLPHFRLGFTPSSGDELQSEYHLPRADAADALAALDEVAPLIAPVLQISELRTIAADDLWLSPQYHRDSLAIHFTWIADTARVLPVVAEVEQALAPFAPRPHWGKVFTTAPEAIAATYPRWSDFATLLHHLDPTAKFHTPALNPLFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F429</accession>
    <name>F4F429_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735325.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28011"/>
    <dbReference type="EnsemblBacteria" id="AEB46675">
        <property type="protein sequence ID" value="AEB46675"/>
        <property type="gene ID" value="VAB18032_28011"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28011"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079903_0_1_11"/>
    <dbReference type="OMA" id="ERGWTGW"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="28942" checksum="E72CC8A0A18350DD" modified="2011-06-28" version="1">MLTIGQLAAYAGVTVRAVRHYHQVGLLPEPDRDASGYRRYSARAVVSLVKIRTLANAGVPLARIGELLDADPSAFADAVRAIDERLRDQIERLETSRRQIAQLVGGDRLTLPPEVTAYLDRLRELGVSERVVEGERDGWILVAARWPERIAEFMPGKLAQLDDPQVVRLYRVLSEIFDDEPGETDDPRLAEVADIMVGLAEQAYRAGEILRDEASDELPQDLVDVLAVESDPRVQRLRDLLRERGWAGWNRMEPLQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4R0</accession>
    <name>F4F4R0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_15450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15450"/>
    <dbReference type="EnsemblBacteria" id="AEB44202">
        <property type="protein sequence ID" value="AEB44202"/>
        <property type="gene ID" value="VAB18032_15450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15450"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_1_11"/>
    <dbReference type="OMA" id="WVPPWER"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="362" mass="37782" checksum="609E4AE6630666EB" modified="2011-06-28" version="1">MSHEERRDSLADQAAAWIPPWQRPAPPAETATTVPAQARPTDDAVDDTGESGPQSPTEPPQLDADDTPPPAGDGQASDASVTLPAGEPVADEPAADASPTLAVGEPVADEQPTDASSTHSVGEPGADEQGTDASSTHSVGAPGADGQAAGERAGTAVGDAGAGRRQRSGRARPAPEPTPLLDDTELRGALEAILLVVDEPVSELTLAQVLEQPPERIGPMLDDIAAGYTAAGHGFDLRRAAGGWRLYTRPEYASYVERFILDGQSVRLTQAALETLAVVAYKQPVTRSRISAIRGVNCDGVIRTLVSRGLVEECGTESDSGAYLYRTTTMFLEKLGLNSLDDLPPLAPFLPDDVEELADASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4R3</accession>
    <name>F4F4R3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="12" type="ordered locus">VAB18032_15465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732870.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15465"/>
    <dbReference type="EnsemblBacteria" id="AEB44205">
        <property type="protein sequence ID" value="AEB44205"/>
        <property type="gene ID" value="VAB18032_15465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15465"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_11"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="11">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="11">
        <location>
            <begin position="199"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="78"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB44205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="467" mass="50402" checksum="4B12C3AA44A05030" modified="2011-06-28" version="1">MSNDDGWVELREPDLDTEEPTGPQPVVAVVGRPNVGKSTLVNRIIGRRQAVVEDVPGVTRDRIPYDAQWSGRSFTVVDTGGWEPDAKDRAAAIAAQAETAVATADVVVFVVDATVGSTDVDEAAVKMLRRSAKPVILVANKADNANIELEATSLWSLGLGEPHPISALHGRGSGDLLDAIMAALPEAPKIVENRPRGPRRVALVGRPNVGKSSLLNRFSGEERAVVDSVAGTTVDPVDSLVTIGGETWHLVDTAGLRKRVGKASGTEYYASLRTAAAIEAAEVAVVLLDSSEPISEQDQRILSMVTEAGRAMVIAFNKWDLVDADRRYYLDKEIDRELRRIPWAIRLNLSAMTGRAVDKLAAALHRALDSWETRIPTAQLNAWLTALVQATPHPVRGGRAPRILFATQAGVAPPRFVLFTTGPLDAGYQRFVERKLREEFGFEGSPIEISVRPRKKLGPGGRGKAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F523</accession>
    <name>F4F523_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_28171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735355.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28171"/>
    <dbReference type="EnsemblBacteria" id="AEB46705">
        <property type="protein sequence ID" value="AEB46705"/>
        <property type="gene ID" value="VAB18032_28171"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28171"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_5_1_11"/>
    <dbReference type="OMA" id="QYWVDHA"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="71"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="208"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="378"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="606" mass="64915" checksum="04F6A6A6A0BEBA0D" modified="2011-06-28" version="1">MSSEPSLSSPPDTPPQPLHPAESTTRTAEELAGAAERAAATQLAPAAPVRLGSVVQLGAVVQLGSVVRLGEVIPAPERVEPDPDADHLLTADAVIRVSADPAALAVGEQLAALLRPATGYPLPVTDVVGQPPAGGIALQLTDEADLGAEGYRLDVTRDGVRLRARTAAGLHHGVQTLRQLLPAAIESRTPVAERWVLPGGSILDRPRYPHRGAMLDVARHFFGVADVLRVIDHLARYKLNRLHLHLTDDQGWRIAIDSWPRLAAVGGATEVGGGPGGHYTQADYRRIVAYAAARHITVIPEIDLPGHTNAALVAHPELAPPGTTPSPYAGTEIGFSYVDPTSERTYDFVADVLGELAALTPGPWLHIGGDEAFKVPAEVYTRFVERVQRIVTGLGKTVIGWHQIAPAAHTDGRILQWWGTRPDDPTTADAVRRGAKLILSPANHAYLDMKYAPDTPIGHDWAAHIDVHQAYDWDPATHLTDVPADAVLGVEAPLWTESVTTRTEIEFMLFPRLPAIAELAWSPQSPQPHPSAQSDRAAQSDRAAQSDRAAHDWSDFRQRLAGHAPRWTAAGIAFHRSPDLPWPAQPSVPAPRPAPPAESAPHTAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F532</accession>
    <name>F4F532_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735364.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28216"/>
    <dbReference type="EnsemblBacteria" id="AEB46714">
        <property type="protein sequence ID" value="AEB46714"/>
        <property type="gene ID" value="VAB18032_28216"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28216"/>
    <dbReference type="eggNOG" id="ENOG5031VYU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168932_0_0_11"/>
    <dbReference type="OMA" id="TTWPVQT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="85" mass="9203" checksum="3036FED52A25AB04" modified="2011-06-28" version="1">MQRTQRRVAGRLARANPTTVFLITLLLVLVAFFTPGPLGGLFTLLLAAAVAALLVTTWPVQTPPTRLIRLLMLTLLVTVGLVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F580</accession>
    <name>F4F580_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735412.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28456"/>
    <dbReference type="EnsemblBacteria" id="AEB46762">
        <property type="protein sequence ID" value="AEB46762"/>
        <property type="gene ID" value="VAB18032_28456"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28456"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_11"/>
    <dbReference type="OMA" id="TRHGKTE"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="22543" checksum="5086E0E09B80E98C" modified="2011-06-28" version="1">MTRLLIWRHGNTDWNAASRVQGQTDIPLNDLGREQAREAAPLLAALRPDAIVASDLSRAADTAAALAALTGLPVRSDARLRERHFGRWQGLLLAEVAAQFPDEYARWRAGDPAPGADVEPLDELGKRMGAALHEIADEMAGGTIVVATHGGAARQGCGQLLGWDQSVLRAVGSLRNCHWTELHHHPEQGWHLRAHNVGRITTPPTEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5I7</accession>
    <name>F4F5I7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09505"/>
    <dbReference type="EnsemblBacteria" id="AEB43019">
        <property type="protein sequence ID" value="AEB43019"/>
        <property type="gene ID" value="VAB18032_09505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09505"/>
    <dbReference type="eggNOG" id="ENOG5032RR4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095649_1_0_11"/>
    <dbReference type="OMA" id="SEPHSWD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="98" mass="10599" checksum="726ABB100E9A8459" modified="2011-06-28" version="1">MVGPLAAFAEPHTYDLCEPHARSLTAPRGWEVVRHEGEFEPPPPTTDDLVALAEAVREAARPAPRPPQDDQNPNAQASTPPSSATSRRGHLRVIPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5J8</accession>
    <name>F4F5J8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731701.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09560"/>
    <dbReference type="EnsemblBacteria" id="AEB43030">
        <property type="protein sequence ID" value="AEB43030"/>
        <property type="gene ID" value="VAB18032_09560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09560"/>
    <dbReference type="eggNOG" id="COG1748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032114_1_0_11"/>
    <dbReference type="OMA" id="KHHFDEI"/>
    <dbReference type="OrthoDB" id="1006830at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="143"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="400" mass="43239" checksum="864958B75FD75210" modified="2011-06-28" version="1">MRVLLVGAGGVGAAVVAIAARRAFFEAMVVADYDPARAARAVDGRDARFVAATLDAGSAEAVAAACREHRITHVLNAVDPRFVMPIFEGAYAAGADYLDMAMSLSKPHPDRPYRETGVKLGDEQFAVAQRWADAGRLALCGIGVEPGLSDVFARYAADELFADIDEIGVRDGANLTVDGYDFAPSFSIWTTIEECLNPPVIWEDGRGWFTTEPFSEPEVFHFPAGIGPVECVNVEHEEVLLIPRWVPAKRVTFKYGLGDEFIEVLKTLHKLGLSATSPVQVGGVSVSPRDVVAACLPDPATLGDRMRGRTCAGTWVRGTGVDGRPREVYLYHVVDNEWSMREYGHQAVVWQTAINPVVALELLAGGAWSGVGVLGPEALPPKPFLDLLTDYGSPWGMEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5L0</accession>
    <name>F4F5L0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_09620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731713.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09620"/>
    <dbReference type="EnsemblBacteria" id="AEB43042">
        <property type="protein sequence ID" value="AEB43042"/>
        <property type="gene ID" value="VAB18032_09620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09620"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_11"/>
    <dbReference type="OMA" id="SYFEWFA"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="17"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="479" mass="50188" checksum="85A776C756EF21AE" modified="2011-06-28" version="1">MELTPFFVAGRPSHGTDEVTVHHPYDGRPVGRTSLATADQVEAAVAAAAEVAASAAALPAHARAAALDHVSRRLAERAEEIAALITAENGKPVKWARAEVGRAVSTFRWAAEEARRYSGELQRLDTDPAATGRIALVRRVPKGPVLGITPFNFPLNLVAHKVAPALAVGAPIIVKPAPATPLSALLLGEILAETELPAGMFSVLPLPNDRAAELVTDPRLPVVSFTGSGPVGASIRRSVPDKHVTLELGGNAAALICEDWSADEDLTFAAQRIATFSNYQAGQSCIAVQRVYVHEWLYDGFLPRLVAAVRELRAGDPTDPLTDVGPLVSVDAARRVEAWVDEAVAAGATIETGGQRDGATYPPTVLSGVPANAKVCTEEVFGPVLVVDRVENDAAGFAAVNDSAYGLQAGVFTHRLDVAFAAARTLEVGGVIVGDVPSYRADQMPYGGVKGSGVGREGLRSAMDDYTDTRVTVLTGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Z0</accession>
    <name>F4F5Z0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734202.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22245"/>
    <dbReference type="EnsemblBacteria" id="AEB45549">
        <property type="protein sequence ID" value="AEB45549"/>
        <property type="gene ID" value="VAB18032_22245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22245"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053496_0_0_11"/>
    <dbReference type="OMA" id="HRDPLNV"/>
    <dbReference type="OrthoDB" id="1555988at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="374" mass="42081" checksum="400F4C6763B4990D" modified="2011-06-28" version="1">MTTQVTLDTTAMLAEADHPVDPDAHYQQGLHRLADALRREARLHPQGAAAVHAGLVAALRTRTAVDRLHAQVPQVGAVPVRRPIFVTGLLRSGTTLVQNLLTEHPALRAPALWELMLPVSEPGADARTLADRAQGYVDEYYRVAPLLRSMHFLDANRPDECHRLTGNAFASMVYGMRYRVPSYDRWLDETGMVQAYRDHRRQLQAILWRRPGRQVVLKCPFHLWHLRDLVQVYPDARIVVLHRDPAVTVASTCLLCETVRGARTATIDRHEIGRQWSTAVGTGLRRYARDRGTLPPTVQLIEADYPALLRDPIAVLRDICDQLGIGLAAPAEAAMRRYLANHPQYSTGAYRYRAEDYGLDPARLAREFAAFHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6E1</accession>
    <name>F4F6E1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731758.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09845"/>
    <dbReference type="EnsemblBacteria" id="AEB43087">
        <property type="protein sequence ID" value="AEB43087"/>
        <property type="gene ID" value="VAB18032_09845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09845"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_11_8_11"/>
    <dbReference type="OMA" id="GCCALVE"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="16423" checksum="CC4697BC9A967981" modified="2011-06-28" version="1">MVSIDHEAWDSADAARLREAQRVELDARYGNDNHEPGEPPSAASVSVFLVARDADGTAIGCGGLRLLDPGSAEIKRMYITPSARGTGVAVAILRALEHQAREAGVRTLLLETGTAQPEAMRFYEREGYHRIENFGPYRGAPLSVCYARDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6N6</accession>
    <name>F4F6N6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavin-containing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_16290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16290"/>
    <dbReference type="EnsemblBacteria" id="AEB44364">
        <property type="protein sequence ID" value="AEB44364"/>
        <property type="gene ID" value="VAB18032_16290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16290"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_8_3_11"/>
    <dbReference type="OMA" id="FMEWEHH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="440" mass="47996" checksum="3FC58EEB0CD36471" modified="2011-06-28" version="1">MAVIGAGAAGLATVKALLDAGCAVVAYEKGDRPGGLWVRDNSSGLSPAYASLHLNTSKRRTEFADFPMPADWPDYPSASRVASYLADYAQSFGLIPHIRFGSTVTRVERDRLWAVTTEFGDTERYDAVVVANGHNWDPRYPDPAYPGTFHGTQMHAHDYRTPEVFLDRRVLIVGMGNSAMDIAVDASHVARGPVLLSARRGVHIVPKYLFGRPADATGGALAALPWRLRQRIAETLLRLAVGTPQTYGLPAPAGGLFQNHPTISDTILHRLTHGEVTPRPGIERLDGERVMFTDGSADPVDVIVWATGYRVSIPFLSPQWLGPDPEQLPLYQRVFHLDDPSLAFVGLMQSTGAALPVVEVQAKLVAAYLSGGYALPGIDEQRHAVQRALRAAIERWGANARPHMRIDFDRYVANLPREIAAGRNRLARGGRTFTAEESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Q7</accession>
    <name>F4F6Q7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transporter inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_16395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16395"/>
    <dbReference type="EnsemblBacteria" id="AEB44385">
        <property type="protein sequence ID" value="AEB44385"/>
        <property type="gene ID" value="VAB18032_16395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16395"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_5_2_11"/>
    <dbReference type="OMA" id="QADWMTL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="286" mass="29013" checksum="463F16FE363D53E8" modified="2011-06-28" version="1">MGGMTTVLTPVTAPVARARPALVLAWVGLGLLALAAAWPALLATAAPDTVDPASALAPISPHHPFGTDQLGRDVYSRVVYGTRMSLLIGLGATTLAVTAGALLGVLAAAAGRAVDELFMRITDILLAFPGLLLALLVIAVLGPGAVNTTIALACAAVPGYVRLARGQALVVRRSGYVSAAVVMGRSRVGIFFGHVLPNALPPVLAFAAVDVGTALMASASLSFLGLGAQPPAPEWGSMLAEGRDYLDSTWGLTVFPGLVVTAAVIACYVVGADLRARFEGRGTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F795</accession>
    <name>F4F795_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731824.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10175"/>
    <dbReference type="EnsemblBacteria" id="AEB43153">
        <property type="protein sequence ID" value="AEB43153"/>
        <property type="gene ID" value="VAB18032_10175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10175"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_996688_0_0_11"/>
    <dbReference type="OMA" id="EMTAGQW"/>
    <dbReference type="OrthoDB" id="2023468at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="261" mass="27809" checksum="63C649FD5448B935" modified="2011-06-28" version="1">MTATIDPAVGQDVAAGQPRPPMSRLTVVELRKLVNTRAGRWLLIAIGVVAAGIIALQLAYAPDDEQTFANFFVPSLFPVGVLLPVLGILSITTEWSQRTALTTFALVPRRERVIIAKLTAVVLAALASVLVSLAVAAVATLIAEATGGAGTWRLDGMLIVHAVVLQVSTALIGAGFGLLLLHTPLAIVAYLVLPIAWSILGALVQPLYRAGEWLDTNRTMEPLFTPEMTSGQWQRLAVSLLVWLVVPLAAGLVRTMRQEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7G3</accession>
    <name>F4F7G3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LuxR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16480"/>
    <dbReference type="EnsemblBacteria" id="AEB44402">
        <property type="protein sequence ID" value="AEB44402"/>
        <property type="gene ID" value="VAB18032_16480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16480"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_2_2_11"/>
    <dbReference type="OMA" id="CAWHIER"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="783"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="848" mass="88255" checksum="DF062CD633BA5E0D" modified="2011-06-28" version="1">MELVGEPGIGKTQALTELTRLARVAGIPIAAGRCTEVTPDSPLTLAAAVTGATGSPGELADALRQAADPAGLLVAVDDFHWAGEDSVRLVRALTQTALDVGLLVVIALRPTQTHTGLLAVLADGRDVGVVERVEVGPLTLPESARLLGCSIKDPQVRRLHERAEGNPRYLLALAAPRGAAATALLGEKASLGPDATRVLEAAAVLGGSVDVAGVAEVAGLPRERACAATSVLVRRDLLRPSDRPREYVFRHPVLHTLYYDDIDICWRAAAHRRARTLLLSRGAPHSVVAPHVERAPQGSDEDLTVLAGAAQEAMAGTPAQAVRWLRVALDLAPAGAHARNELASALVGALLASGQPTASSVLLHQILRSDPPLSWEARAHALVPGALAECLLGRAREGGSLIAAALAEAPEDPPAVLVRLAVVQGVLASLEGVALTPGVADVALRVARVHGDRLGEMGVLSVRAFGAGGGAASAADLSAAAAIADAAADPDLAADPECLVMLASAESYSGRYRDARRHAARGVTVIRRSGGRHLLPLLYNTLSNSCRRLGELDAAQEAAAEAARIAEQMGAWRLHGLALALRSLSLAWLLPQGDREPVDLAEQAAAILPPGSSTWSATAGLALAQAALAGGDPRRAVTVILDFGGGPGLDDIPDVLRPWSYELLAAASGRADLPLAEWASRAAAVVDRMGVPYLRPYAVSARAHLLRSRNDLAGATALFREAAALFHTAGLAFSQAVALAEAARCQPGAGRADLALAREVARRCGAGRALAEYRTRPSVTEVTHPMLSVLTRREQEIASMAGTGRKTKDISNSLAISPRTVDVHLTRIYRKLNIATRAELARLMASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7N3</accession>
    <name>F4F7N3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA ATPase forming ring-shaped complexes</fullName>
            <shortName evidence="2">ARC</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arc</name>
        <name evidence="5" type="ordered locus">VAB18032_22850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer. Assembles into a hexameric ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734322.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22850"/>
    <dbReference type="EnsemblBacteria" id="AEB45670">
        <property type="protein sequence ID" value="AEB45670"/>
        <property type="gene ID" value="VAB18032_22850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22850"/>
    <dbReference type="eggNOG" id="COG1222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036054_0_0_11"/>
    <dbReference type="OMA" id="CVDEFKE"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02112">
        <property type="entry name" value="ARC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022482">
        <property type="entry name" value="Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03689">
        <property type="entry name" value="pup_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="270"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="281"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="593" mass="65763" checksum="9C3E9AB03DB56E71" modified="2011-06-28" version="1">MARSDDADSRAARWEKEAHDLSTQVAFLQEELALVRRKLTESPRHVRQLEERLSATQAQLARLTENNERLVSTLKEARAQIVTLKEEIDRLAQPPSGYGVFLARHDDGTVDVFTGGRKLRVAVSPSLDVGELQRGQEVLLNDALNIVDAFGYERVGEVVMLKEILAGPEGAPGDRALVVSHSDEERIVHLAETLIGSAIRAGDSLMIEPRSAYAYERIPKSEVEELVLEEVPDVDYSDIGGLHSQIEQIRDAVELPFLHADLFREHQLRPPKGILLYGPPGCGKTLIAKAVANSLAKKIAERRGEEKHTSFFLNIKGPELLNKYVGETERHIRLIFQRAREKAGEGTPVIVFFDEMDSVFRTRGSGVSSDVENTIVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAKDIFSKYILSGLPLHADDLAEHGGDAQATVAAMIDAVVLRMYSETEENRFLEVTYANGDKEVLYFKDFNSGAMIQNIVDRGKKMAIKEFLTSGRKGLRLQHLLDACVDEFRENEDLPNTTNPDDWARISGKKGERIVYIRTLVSGGKGTEAGRSIETASNTGQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7S7</accession>
    <name>F4F7S7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_23070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734366.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23070"/>
    <dbReference type="EnsemblBacteria" id="AEB45714">
        <property type="protein sequence ID" value="AEB45714"/>
        <property type="gene ID" value="VAB18032_23070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23070"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008270_1_0_11"/>
    <dbReference type="OMA" id="YPPHALI"/>
    <dbReference type="OrthoDB" id="175945at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="365"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="887" mass="94760" checksum="7EDA4BCA5B6D7353" modified="2011-06-28" version="1">MADRRNQLVARVRELLADALGASRNRSAAAQTAVATARERAVRVRRAALGVPQRVGAERDRRLAEIDAQHTSRLAALARQAAEAATREAPGAGSAPWTQWRRSPAGRGEPPGATRIGTVLLPEAEPVPALVALLDGGHVALDGDAEGCAAVVSALLLRSLGRAAPGDVRVVGYDPDHLGGGLAGFAPLGTAGLLTFVGPGGLGRLLDDLVEQIRRINETVLAGEHATLRELAAATGRRPEPWRVAVLLGGEELSRHERGQLDRVVRAGAACGVHLIVRGVPLPEDPTVTRVRVTGAEARIGTLPVRLDPPPPATLVTETCRQIATVVSAGPAPTPFTDLLPAPEQMWQEDSATGLTAPIGEGPHGRPVLVTLGDYPPHALIGGPSGTGKTNLIFAWIGALAARYSPAELEFYLLDFKEGVSFARFAQGRRDPSWLPHMRLVGINVNTDREFGLALLRFLAEELRRRADAAKKHEVTKLAELRAVDPTGHWPRIVAVVDEFQMLLAGRDAVAREAADLLEDLARRGRSQGIHLVLASQDVRGIEALWGRPALVAQFTLRIALPKALRILAESNDAAQSLPKFHAVVNAESGLPDGNEVARIPSASDWETWSELQHRLWRMRPAEAAPARLFDGDAIPRLADAPDFRALTAPEVGTPRNPVALLGEIIDVQARSAALRLPRAPGRNLAVLGTRVDEACAVLDAAARSLARQHRPGTARFSIACLDQDADPATRALYEDLADDAAWYDEESVAELLAETADGLGAPGSSSAPHYLLLFAVDAAAGALAARTGRATGAAHLRRILHDGPERRTHVLAWWRGVARMRADLGGPTARVDQIGAWVALDTHGGELGSLYPGTGPDWYPRPWRGLFFDRAVHRTGQTIIPYGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7X9</accession>
    <name>F4F7X9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lao/ao transport system atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29416"/>
    <dbReference type="EnsemblBacteria" id="AEB46954">
        <property type="protein sequence ID" value="AEB46954"/>
        <property type="gene ID" value="VAB18032_29416"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29416"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043725_1_0_11"/>
    <dbReference type="OMA" id="DWRPPIV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="32223" checksum="81582B2EB7029F7C" modified="2011-06-28" version="1">MLVDRARAGDHRAVARLITLVESGDETLPAIAAALAPYAGQAQVVGLTGSPGVGKSTTTNELVRALRARGRRVGVLAIDPSSPFTGGAILGDRVRMQDHATDPGVYIRSMSSRGHLGGLSAATPQAVRVLEGAGCDVVLVETVGVGQAEVEVASLADTTLVLLAPGMGDAIQAVKAGILEIADVFVVNKADRDGADATVRDIQGMIALGERGPGEWRPQVVRAVAVRGEGVDDIAAAIDKHRGWLVEHDELRRRREARAAAEIEAIALGVLRARIGSLRDGTQLPALAAEVAAGATDPYAAANTLLTQLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8C0</accession>
    <name>F4F8C0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16805"/>
    <dbReference type="EnsemblBacteria" id="AEB44465">
        <property type="protein sequence ID" value="AEB44465"/>
        <property type="gene ID" value="VAB18032_16805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16805"/>
    <dbReference type="HOGENOM" id="CLU_3190364_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="46" mass="5483" checksum="455BBA47193CB0E3" modified="2011-06-28" version="1">MTVKALIFDFDALLMDTETTLLESWRGEWRRHGLKRFALSRQRVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8J0</accession>
    <name>F4F8J0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_34 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733190.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17155"/>
    <dbReference type="EnsemblBacteria" id="AEB44535">
        <property type="protein sequence ID" value="AEB44535"/>
        <property type="gene ID" value="VAB18032_17155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17155"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142189_0_2_11"/>
    <dbReference type="OMA" id="KARLGIM"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="12960" checksum="5B18BF42019A292E" modified="2011-06-28" version="1">MTAASGAPDPYAPSAHPVNGLDDVVHQRVRLGILTIAHEARRVEFGYLRTQLELTGGNLSKHLSVLEEAGLIEIEKGYEGRRGRTWITLTAAGSTALADEIGRLKLLIARVETTDTAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8N7</accession>
    <name>F4F8N7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734432.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23410"/>
    <dbReference type="EnsemblBacteria" id="AEB45780">
        <property type="protein sequence ID" value="AEB45780"/>
        <property type="gene ID" value="VAB18032_23410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23410"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1834324_0_0_11"/>
    <dbReference type="OMA" id="EHADRLW"/>
    <dbReference type="OrthoDB" id="1718517at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="14832" checksum="04F7CE2DEDF9BD9B" modified="2011-06-28" version="1">MPSSWLNEVAAATAEGGHIHTDDEALSTTLASPLAPHSTGLTPSQLLAAAYASCLHHAAVEAAGGITDEAHTVQVRAEAKLGRDDDGRYRADVHASISSVGLSREQLAELVEHADRLWPFSRDDGGRHRLTVTPAENGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8R3</accession>
    <name>F4F8R3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaA</name>
        <name evidence="9" type="ordered locus">VAB18032_23540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734458.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23540"/>
    <dbReference type="EnsemblBacteria" id="AEB45806">
        <property type="protein sequence ID" value="AEB45806"/>
        <property type="gene ID" value="VAB18032_23540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23540"/>
    <dbReference type="eggNOG" id="COG3004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015803_0_0_11"/>
    <dbReference type="OMA" id="MGLMLRC"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0050">Antiport</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="442" mass="47028" checksum="95A1BDB55267D82D" modified="2011-06-28" version="1">MTDHNPRPPHRGVRRLFSRTSWPEARFLADVLRTETVGGVLLLVGAVIALIWANSPWGDAYTELGRWVPWPGGSTLHLDLDLATWAADGLLAVFFFVVGLELKREFVAGELRDPRRAALPVVAAVGGMALPALIYLAVNFTAGGEGLRGWAIPTATDIAFALAVLAVIGAYLPQGLRAFLLTLAVVDDLLAITIIAIFYTDDFNLLPLLGAVAPIALFALLVQRRRTWWWALIPLALIAWTLVHSSGVHATVAGVLLGFTVPVLAGRSRDGRPVPGLAERLEHTWRPVSAGFAVPVFAFFAAGVSLRGADLGAVVSDPIVIGIVLGLVVGKTVGILGSTFLLARFTRARLDEDITWSDLLGVSLLAGIGFTVSLLIGELAFGAGSEAGANVKAAVLTGSLIAALLASVVLVRRNRVYRMIALKEQVDLDQDGVPDVYQRPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F964</accession>
    <name>F4F964_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_04830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730766.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04830"/>
    <dbReference type="EnsemblBacteria" id="AEB42092">
        <property type="protein sequence ID" value="AEB42092"/>
        <property type="gene ID" value="VAB18032_04830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04830"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OMA" id="PGNLMLD"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="468" mass="49136" checksum="6836FCC00CDA6A45" modified="2011-06-28" version="1">MLSPGVQLGNRYRLDERIASGGMGDVWRGTDQVLGRTVAVKSLLPALLDEPGFAERFRGEARTMATINHPGVVDVYDFGSDQQIAFLVMEYIEGDPLSATLSRVGRLTPARTMALVAQAADALHAAHVKGIVHRDVKPGNLLVRPNGTLVLTDFGIARSELVGQLTAAGSVLGTASYISPEQATGQVATPASDVYALGVVAYQCLAGRRPFEGDNPLDIAMRHVRETPRPLPSDIPPQVCALVERAMAKDPKDRWASAAVLAGVARQLKAALSRQARPGGSAPISAAPASPAPVGRNPATPPPGRAQVPQPPRPPAAPHSPAAPRPPAAPHAPAAGHRPVAARQPVAQPRPTTVAPAATGYPRGAAPIPQAYAPQAGQSRPAPRRSRSGMWFLAILLGTLVVVCSGVVSYRLKDSINNSMPVEVSVHTVTSGVLGPDGRDDPALTAYRRLDQPRPGDETTTSEGRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9B9</accession>
    <name>F4F9B9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731984.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10975"/>
    <dbReference type="EnsemblBacteria" id="AEB43313">
        <property type="protein sequence ID" value="AEB43313"/>
        <property type="gene ID" value="VAB18032_10975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10975"/>
    <dbReference type="eggNOG" id="ENOG5031IGV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117155_0_0_11"/>
    <dbReference type="OMA" id="SYERGNR"/>
    <dbReference type="OrthoDB" id="1918333at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045629">
        <property type="entry name" value="DUF6232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19744">
        <property type="entry name" value="DUF6232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="159" mass="17888" checksum="72940E65D4566E5D" modified="2011-06-28" version="1">MALYYQDDTVQVSSESIRAGGHVIPISEVTYVWHQKGRTTLAVRGRVLGRGVLVLLLSLPPLVGLVCVLSLVWSAPDRGWVPALVVLVACLVIALALVPFLEIPLGWLDRSYERGNRVQELWVQYRGQEVMMLRTPDALRFGQIYRAVQRAVEQQGDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9H0</accession>
    <name>F4F9H0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17220"/>
    <dbReference type="EnsemblBacteria" id="AEB44548">
        <property type="protein sequence ID" value="AEB44548"/>
        <property type="gene ID" value="VAB18032_17220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17220"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127198_0_0_11"/>
    <dbReference type="OMA" id="VLWRKPP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="27203" checksum="8D7C7D5F0A8B3586" modified="2011-06-28" version="1">MAGVEEVAVVVAHNERVTLRVGDVFLKVDSDQARIDVEVEAMRLAPVPTPEVLWRKPPVLAIAAVPGQALGRLGEPSPASPAAWAAAGAAIRTLHDAPPPPWVGKKLVGLDAELERECAWLVDNGVLPADLVDRNREIAQAAMRPWTPVFMHGDLQITHIFTNGDEVTGVIDWSEAAPGDALFDLAILTLGHEERLGDLLAGYGTDVDRDVIRAWWSLRSLLASRWLIEHGFDPSLPGCEFDVLRAQMSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9H5</accession>
    <name>F4F9H5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733208.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17255"/>
    <dbReference type="EnsemblBacteria" id="AEB44553">
        <property type="protein sequence ID" value="AEB44553"/>
        <property type="gene ID" value="VAB18032_17255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17255"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_9_11"/>
    <dbReference type="OMA" id="CGAACWG"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="14538" checksum="08E0864D411A52BF" modified="2011-06-28" version="1">MNVRERKKLTARLMTSLLRGDLPAVRALLRAGADPNAADRDSTTPLYLAAVQNERAAVRILLAAGADPNIESGRGDEGTPLTAAAAWGHDDVVRELLAQGADPNLREDHGSGLSPLEWAVRNGNSETQALLGAAGATPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9J1</accession>
    <name>F4F9J1_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733224.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44569">
        <property type="protein sequence ID" value="AEB44569"/>
        <property type="gene ID" value="VAB18032_17335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17335"/>
    <dbReference type="HOGENOM" id="CLU_2959582_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="59" mass="6624" checksum="1407B7A120E511BE" modified="2011-06-28" version="1">MASTGAHDRFWIDVDRWLRGPDPRTLLMTARMDARDPSVLDELSSADGSLAFFVDLNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9K0</accession>
    <name>F4F9K0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase NNMT/PNMT/TEMT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17380"/>
    <dbReference type="EnsemblBacteria" id="AEB44578">
        <property type="protein sequence ID" value="AEB44578"/>
        <property type="gene ID" value="VAB18032_17380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17380"/>
    <dbReference type="eggNOG" id="ENOG50306AZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100163_0_0_11"/>
    <dbReference type="OMA" id="MFFVAES"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000940">
        <property type="entry name" value="NNMT_TEMT_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867">
        <property type="entry name" value="PTHR10867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01234">
        <property type="entry name" value="NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51681">
        <property type="entry name" value="SAM_MT_NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="28897" checksum="1AF1855F843484F9" modified="2011-06-28" version="1">MALTPEAGGRGDSASSVPMQSPGPVNTEVEWDRFDPQAYVRHNYADLRSDDRELLRRTRDFFAAAKLTDARCVDVGSGANLYPALTLLPFARAIDLCELSTSNVRWLRTQVDGYDELWDPYWQVCVEHPAYAALSDPRQRLAQVGQVCRTSVFDLPQHTWDAGTMFFVACSISADRAEAEHAVARFLRALRPGAPFAVAVMLGSVGYRVGLRSFPAVALHRAEVVAGIAAGAYDVTVHEERPRPPLRDGYQSMLLTTGRTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9P5</accession>
    <name>F4F9P5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridine nucleotide-disulfide oxidoreductase dimerization region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733278.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17605"/>
    <dbReference type="EnsemblBacteria" id="AEB44623">
        <property type="protein sequence ID" value="AEB44623"/>
        <property type="gene ID" value="VAB18032_17605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17605"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_3_11"/>
    <dbReference type="OMA" id="WGAHAAT"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="358"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="473" mass="49503" checksum="2E304A0D85536B52" modified="2011-06-28" version="1">MTELAYDVVVIGAGPVGENVADRVVQGGLTAAIVERELVGGECSYWACMPTKALLRSGSALRAARQVPGAREAVTGDLDAAAVLARRDSIVANWRDDGQVSWLESAGIALHRGHGRLSAAKVVEVTDADGATTTLTARHAVVVATGSGSRMPDIPGLRAAAPWSSREAAAATSIPRRLAIIGGGVVATEMATAYAALGSSVTVLARDGVLPSVERFAAEQVTQSLREAGVSLHVDAEAVSVHRDDAGTVHVDTSQGERVEADEVLVAIGRTPNTQDIGLDTVGLTPGDWLTVDDTMRVVDGGDWLYAAGDINRRALLTHQGKYQARAVGDVIVARAKGEKVDDGRWGRHVATADERAVPQVVFTDPEIAAVGLTAAAAEAAGLRTRVVDYNLGAVAGATLHADDYQGQARMVVDEDRKVIVGVTFVGPDVAELIHAATVAIVGEVPLDRLWHAVPAYPTVSEVWLRLLEAYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9S4</accession>
    <name>F4F9S4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734502.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23760"/>
    <dbReference type="EnsemblBacteria" id="AEB45850">
        <property type="protein sequence ID" value="AEB45850"/>
        <property type="gene ID" value="VAB18032_23760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23760"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129810_0_0_11"/>
    <dbReference type="OMA" id="RMVFHLG"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016672">
        <property type="entry name" value="Polyketide_Synth_CurC_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016602">
        <property type="entry name" value="CurC_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="14352" checksum="AA3CBDB87E0A3DB7" modified="2011-06-28" version="1">MRDLALVAARDVPADRRRGGELRVLLGPRTVGSTSGFMGVATMAPGERIAEHYHPYSEEFLYVARGAITVDLDDEPVGLTAGEALFVARNVRHRLRNTGDVPAEVVFHLGPLAPRPELGHVDTELVEQRDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9W1</accession>
    <name>F4F9W1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_23945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734539.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23945"/>
    <dbReference type="EnsemblBacteria" id="AEB45887">
        <property type="protein sequence ID" value="AEB45887"/>
        <property type="gene ID" value="VAB18032_23945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23945"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="YVFACHE"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="286" mass="30719" checksum="6949862940D12E91" modified="2011-06-28" version="1">MTTANPVLSPAKRRPVSWGNPLTYALALAVAAVSITPVIYVVIGGFRTTPQIVANPAGMPDPWVFDNYIRVLTQGNFWRQAFNSAVVSLGTTLGVVALGVSAAFVLARYTFRGREVLYTFFTLGLLFPAGAAILPLYLMLRDLGLINSYYAVILPQVAFSLPLTIVILRPFLSAIPRELEDAAAIDGTGRLGFLWRIMLPLSRPALVTVGILAFVTSWNAFLLPLLVLGDASLHTLPLGVQQFSSQYSSDTAGILAFTSLAMLPALLFFTFAEKQIVGGLQGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAC9</accession>
    <name>F4FAC9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730864.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05320"/>
    <dbReference type="EnsemblBacteria" id="AEB42190">
        <property type="protein sequence ID" value="AEB42190"/>
        <property type="gene ID" value="VAB18032_05320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05320"/>
    <dbReference type="eggNOG" id="ENOG5031YRZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299283_0_0_11"/>
    <dbReference type="OrthoDB" id="2054758at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309193" evidence="2">
        <location>
            <begin position="28"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="20311" checksum="D8DE759A6D1B5C32" modified="2011-06-28" version="1">MTGQAALLRTSIVALTAALVASGCTSADTGPESASNAAPGAPAPAEPTPDAEPTPAATPAAVDASKGGSTDGGATGGGSTGGGSTGGGSTGGGSTGGGQSGTKAGNGPTITYFRVAQKPSCPAGTNVNPIPGTPVVLEWKVANVDSVALSVDGGGIYADNYPPTGSETLTFPCEGAGGDTQRHTYQLTVRNSHGKQTKTLAVTATVNDVPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAF0</accession>
    <name>F4FAF0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732048.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11295"/>
    <dbReference type="EnsemblBacteria" id="AEB43377">
        <property type="protein sequence ID" value="AEB43377"/>
        <property type="gene ID" value="VAB18032_11295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11295"/>
    <dbReference type="eggNOG" id="ENOG502Z7SZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053604_0_0_11"/>
    <dbReference type="OMA" id="GCFGLHE"/>
    <dbReference type="OrthoDB" id="1396351at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="33927" checksum="005684BD747D0B97" modified="2011-06-28" version="1">MTAACAPAGSDRLPAAVWLPRAWAHEERADALTAGHRRRRAARQRHAIDDFLYEYYGTRPSVLRRWHPGVGIRLEPGPDGPAPNGQWRWYVTDSDGLVGFDAAAFLADRAESVRFISRLLSAIATRPAFTGCFGLHEWAMVYRQREHRHPLPLRLGQDGTDAVVEAHQIRCSHFDAFRFFTPEAVGLNRLRPTRASQVDLDQPGCLHAAMDCHKWATKLGPAVPGELALDCFELARDIRLLDMQASPYDLSSYGEPAVAIETPEGKAEYVARQREFAERAGRLRARLIEVCATLLETVEQPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAF6</accession>
    <name>F4FAF6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_11325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732054.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11325"/>
    <dbReference type="EnsemblBacteria" id="AEB43383">
        <property type="protein sequence ID" value="AEB43383"/>
        <property type="gene ID" value="VAB18032_11325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11325"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085366_0_0_11"/>
    <dbReference type="OMA" id="AQFKAVI"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="219" mass="21865" checksum="4E34D9C3BE30BB47" modified="2011-06-28" version="1">MNKAELIEALAVRLGDRKTATAALDAVLAEVQAAVTKGEKVAITGFGAFEKRVRGARTARNPRTGEAVKVKKTSVPTFRPGAGFKEMVASGKVPKATAAAKKVAAATAKTTGAKAAGAKAAGAKATGAKATGAKKTATATKTTAAKKTTATKTTAAAKKTTAAKTTAAKKTTAAKKTTTKKATPAKKTATKSTTAASKTTAAKKAPAKKAPAKKAATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAG9</accession>
    <name>F4FAG9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732067.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11400"/>
    <dbReference type="EnsemblBacteria" id="AEB43396">
        <property type="protein sequence ID" value="AEB43396"/>
        <property type="gene ID" value="VAB18032_11400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11400"/>
    <dbReference type="eggNOG" id="ENOG5032SM3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116291_0_0_11"/>
    <dbReference type="OMA" id="WANEFSD"/>
    <dbReference type="OrthoDB" id="1884713at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="207" mass="21123" checksum="3CED161C90B7402F" modified="2011-06-28" version="1">MSRISESPGETRRAKDAAPAADRTNRTAALVATAVALPVALLVGTLAFVNLAPDSSTATPDPSPSAARPQSTAPVEMAAPALAERPATVCRALLSQLPASIRDLPQRPVSAGPEQNAAYGDPALTVACGGTEPEVAPTDHIYLVNAVCWHGVEEADATVLTTLDRETAVTVRVPHFYGEALQWAAPIASTVVASVPSAGPVPSGCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAL8</accession>
    <name>F4FAL8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_17655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733288.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17655"/>
    <dbReference type="EnsemblBacteria" id="AEB44633">
        <property type="protein sequence ID" value="AEB44633"/>
        <property type="gene ID" value="VAB18032_17655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17655"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_2_1_11"/>
    <dbReference type="OMA" id="MRPCGDF"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="368" mass="37826" checksum="3BDBC6AAF3295D41" modified="2011-06-28" version="1">MSATRAPAPPHRQRAVDLVRTGRSVPTLLRHLAVAVAAALVVLLVSYQLDSYRNFQLATVAAYLCATAGLTILTGLCGQLSLGHGALMATGAYTVALCQSAFFDRGVTSGAVLLLSLVAAVAVTVTVGLVVGVAAARLRGPYLAGLTLAVAVVVPALTVTFDGLFNGEQGLPVPVAPAPAGLGLYFPHERWQLWMAAGATLLCLVVLANLVRSRYGRLFRAVRDDEVAARLAGIHVARTQVIAFVVSAAGAGLGGALLAVLAQSVSPGAFGLNLSLFLLMAVVIGGLGRLAGAVWGAFLLVVLPDLTHSLTNLFTLSPATAQRLEGNLPLAIFGATLIVVMIAAPGGVQGQLSRLTRALRARRPAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB11</accession>
    <name>F4FB11_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734626.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45974">
        <property type="protein sequence ID" value="AEB45974"/>
        <property type="gene ID" value="VAB18032_24380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24380"/>
    <dbReference type="eggNOG" id="ENOG50322C6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1958636_0_0_11"/>
    <dbReference type="OMA" id="WAAYPAY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="128" mass="13759" checksum="11879239B7B60671" modified="2011-06-28" version="1">MSARGYPDVLRYPVMPTPVRITVLVFGLLSLLFALATVHRLLTEGGSLGAAVFFAAMTAACLLVTTALATRRTWAPFPAYALAGLLAAASLGLFGAITCVGVALLAWVLWALNTRASRDWFGRRHRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBC3</accession>
    <name>F4FBC3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_05465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05465"/>
    <dbReference type="EnsemblBacteria" id="AEB42219">
        <property type="protein sequence ID" value="AEB42219"/>
        <property type="gene ID" value="VAB18032_05465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05465"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_11"/>
    <dbReference type="OMA" id="INYPKGG"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="500" mass="53792" checksum="7A79F59A3D6B9057" modified="2011-06-28" version="1">MGARSSTARTVAGRTDRVVVVGAGLGGLACALHLAGSGRQVTLLEREPVPGGRAGRLSVDGYEFDTGPTVLTMPDLIAEALGAVGEELTDWLDLVPLDPAYRAYYPDGSTLDVITDTARMAAEISRVCGPREADGYLRFVDFARNLWRLERADFIERNFDAPTDLLTGNLLKLMATGAFRRLQTKIDQFFRDPRTRRIFSFQAMYAGLAPHDALAIYAVIAYLDSVAGVFFPRGGIHAVSRALAGAAEKHGVRIRYGTTVTRVETANGRATGVVTADGEFVPADAVVLNPDLPVAYQDLLPPARQRRLAYSPSCVVLHVGSTQGYGRIAHHNIHFGRAWKGTFDEVIRRGELMTDPSLLVTNPSRTDPAVAPAGRHTYYVLAPVPNLDRAPFDWRGDLTAHYTDELILTLEQRGYVGFGAGVEVLQAITPADWAEQGMAAGTPFAAAHSLFQTGPFRPANLHRSLSNVVFVGSGTQPGVGVPMVLISGKLAASRITGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBI1</accession>
    <name>F4FBI1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732112.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11645"/>
    <dbReference type="EnsemblBacteria" id="AEB43443">
        <property type="protein sequence ID" value="AEB43443"/>
        <property type="gene ID" value="VAB18032_11645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11645"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_2_1_11"/>
    <dbReference type="OMA" id="WPSQLDD"/>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="391" mass="41607" checksum="ADD85B0DB612CC63" modified="2011-06-28" version="1">MSRYDETTLARVALTWLAEPGTRSVYALVTELGPVAALELLLDGAAPYEDLRDSVAARSRAGDARAIAAEALDRGERLGARVVVPGDDEWPGTVEELRKLRLSDARRRVDRETAPPLCFWVRGPWPLAEALDRSVAVVGARAATPYGLHVARQLGYGLADRDWTVVSGGAFGIDAAAHRGALSAGGRTVAVLACGVDRPYPVGNTALFDRIADSGLLVSEWPPAAEPLRPRFLIRNRVIAAGTKGTVLVEAAARSGATQTTRRALALNRPAMVVPGPVTSAMSVGTHEILREEPGARLVTGLAHVLEEVGRIGELAPVPRGPDRPTDVIDDDARAIVEAMPRRGTIGVDDLAARAGLAVRTVLRKMSLLEELALVVRRDDGYALVPPRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBM4</accession>
    <name>F4FBM4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732155.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11860"/>
    <dbReference type="EnsemblBacteria" id="AEB43486">
        <property type="protein sequence ID" value="AEB43486"/>
        <property type="gene ID" value="VAB18032_11860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11860"/>
    <dbReference type="eggNOG" id="ENOG5030DIG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="LNSARWR"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="66" mass="7030" checksum="EB2F3187E59B0300" modified="2011-06-28" version="1">MDLTGAQWRKSTKSGNNGGSCVEVADNLPGVVLVRDTKDREGGTLRLTPSSWQSFVDLARQIGPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBR6</accession>
    <name>F4FBR6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733371.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18070"/>
    <dbReference type="EnsemblBacteria" id="AEB44716">
        <property type="protein sequence ID" value="AEB44716"/>
        <property type="gene ID" value="VAB18032_18070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18070"/>
    <dbReference type="eggNOG" id="COG2867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1651183_0_0_11"/>
    <dbReference type="OMA" id="FKFRLTM"/>
    <dbReference type="OrthoDB" id="1691158at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="17669" checksum="BB4AD4642FBD2CF9" modified="2011-06-28" version="1">MAGHTDNSIIIDAPMDLVWRMTNDVATWPELFSEYAKAEILRRDGDTVRFRLTMHPDEQGNEWCWVSERTPDAGRRTVRAQRVEPGWFKYMSLFWEYREVAGGVEMRWVQDFEMRPDAPADDAQMTNRLNRNTAVQMERIRTLVESAARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC40</accession>
    <name>F4FC40_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CopC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734690.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24700"/>
    <dbReference type="EnsemblBacteria" id="AEB46038">
        <property type="protein sequence ID" value="AEB46038"/>
        <property type="gene ID" value="VAB18032_24700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24700"/>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348461_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313780" description="CopC domain-containing protein" evidence="5">
        <location>
            <begin position="31"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="6">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="21194" checksum="481731328CCA799E" modified="2011-06-28" version="1">MTARPGRLRAALLTVFVAAALAATPGVGLAAGDLTATDPPDGAALDAPPSAVTLTFSRRPDVDESHVSVRNDAGQDRTAGALAGDDGNSLRMPVALKPGGDYTIAFHVVFADGSDLTGIKRFSVGTGAPPAPLSAEVAQRTRESVQQRHSGHGPDWIRSSMLMLNGLVLVGVVVLLVVRRPRKTTTGARWVLREPEDESDTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCD4</accession>
    <name>F4FCD4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplB</name>
        <name evidence="7" type="ordered locus">VAB18032_01145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735951.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01145"/>
    <dbReference type="EnsemblBacteria" id="AEB47313">
        <property type="protein sequence ID" value="AEB47313"/>
        <property type="gene ID" value="VAB18032_01145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01145"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_11"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="279" mass="30536" checksum="3D7EED6CD41C4E6E" modified="2011-06-28" version="1">MAIRKYKPTTPGRRGSSVADFAEITRSTPEKSLLAPLPKKGGRNAHGRITARHQGGGHKRQYRIIDFKRVDKDGVPAKVAHIEYDPNRTARIALLHYADGEKRYIIAPKDLKQGDRVESGPGADIKPGNNLPLRNIPVGTTIHNVELRPGGGAKLARSAGVGIQLLGREGVYATLRMPSGEIRRVDVRCRASIGEIGNADQSNINWGKAGRMRWKGKRPTVRGVAMNPVDHPHGGGEGKTSGGRHPVNPQGKPEGRTRRKGQPSDRLIVRRRYATRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCH8</accession>
    <name>F4FCH8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ResB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_05895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730978.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05895"/>
    <dbReference type="EnsemblBacteria" id="AEB42305">
        <property type="protein sequence ID" value="AEB42305"/>
        <property type="gene ID" value="VAB18032_05895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05895"/>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023092_0_0_11"/>
    <dbReference type="OMA" id="RWFWRQL"/>
    <dbReference type="OrthoDB" id="1518243at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="36"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="546" mass="59532" checksum="6FFDA6031D469474" modified="2011-06-28" version="1">MTAVDDRPGAPAEAPRRRTNPLLALARNSWRQLTSMRTALVLLFLLAVAAIPGSVLPQRGVNPEDVRDFFTEHPDLAPWLDRIGAFEAFSSVWFSAIYLLLFTSLIGCITPRLVDHVRALRARPPAVPKRLGRLPQHTVVPAPDGGVAAVAEALRRRRWRVVVRGDEVSAEKGYLKETGNLIFHTSMVLVLLGVALGSWYGWQGNRLLVAGADHVFCNTRQQYAEVKLGPRVGDDLPRFCLQLDEFDARFLPTGQPSFYNAKVTVDEDGDPPRTAEFSVNSPLRLDGANVYLLGHGYAPVIRYTDRFGRSQTSAVPFLSNGDLGLTSEGLAAFPDANVDPATGERKPDLQMAFDGLYLPTAPQEPPFTRSEHPTEENPLLGLVAYRGNLGLDGGIPGSVYQLDQRQVRNGRLTEIGAKELRLGESWTLDDGTTVEFLGSEPYIVLSVRYDPGTTLLLISSVGLVLGLMGSLFVRRRRVFVRLLSADAADPADGSPTRGSSLIEVGGLPRTEHPGFADEFAQLVAAMRGERPADEVDGVPDAREGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCN4</accession>
    <name>F4FCN4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12070"/>
    <dbReference type="EnsemblBacteria" id="AEB43528">
        <property type="protein sequence ID" value="AEB43528"/>
        <property type="gene ID" value="VAB18032_12070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12070"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477289_0_0_11"/>
    <dbReference type="OMA" id="HLRFCAL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="571" mass="61046" checksum="063709BCA2EB4692" modified="2011-06-28" version="1">MSGWATGRRSRPRMSTPADGRADRGPADLLADARDRPDGEARIAELERVAALAEATGDAGSAMDAWAELVEAHLRGGQRWRLFEPVRRCLDTARRPQRPGGGRRPVGPDDETLRRYQRYAVEALLGTSRIGLDQARTVLDGLDDPARHDGEALVAQLRCRIADHVGDEPTARHWLRRWQTAGPDPAAGCPDCLPVRQAELLAGWGDWAEALAAVEPLLDGTVGCTAQPEAALAGALLPWLRAGAAQRAAQAHVRAYRRHRVAPDGFDHLATHLRFCALGGHLDRGLEILVEQVPRLDQPHDDLAVMEFAAAGALVCALAAEQRGDRTVRRPAYHGRPAATVTVAALGAELLAVATELAGSFDARNGTGHQSGRMAAWLAERPSAPPVPLPADEPIDDEPIDGEPVDGGDLAGDDEPAGERWSDGGTAGERRSMAEEELGALSVAMITTVLDRRGDRYALDSAGTVLGRWGDAVIQFRRAGERGDVLHARVVADRRLPTARRAEAYAFCNGWNRDRLLPKAYVHDPGDGELVLAGEVVTDLAYGVAPAQVTVLVDAAVRTGVAYAEAVAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCS4</accession>
    <name>F4FCS4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12270"/>
    <dbReference type="EnsemblBacteria" id="AEB43568">
        <property type="protein sequence ID" value="AEB43568"/>
        <property type="gene ID" value="VAB18032_12270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12270"/>
    <dbReference type="HOGENOM" id="CLU_2412363_0_0_11"/>
    <dbReference type="OrthoDB" id="2101864at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="92" mass="10044" checksum="917C42DBBB1B2C52" modified="2011-06-28" version="1">MHGLWVSHLLDIRATSEYCTAKPLASTATSADWLPLRHVCRYADGTSTDLVPGYVNPIIFLCLFIAVVSTALALRSARRSRAAEPTTLESPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD73</accession>
    <name>F4FD73_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46103">
        <property type="protein sequence ID" value="AEB46103"/>
        <property type="gene ID" value="VAB18032_25025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25025"/>
    <dbReference type="HOGENOM" id="CLU_962928_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="32534" checksum="7289628DD51ED3C2" modified="2011-06-28" version="1">MAVGSIAAMIKVSQATLYNYLNGTTLPPVDTLDDLLSVLQATPTERKELQELRDDLAVRRNLRRGPGQPVIEVAHGDEVEIANIEGTHEVSPEDYNLAGPFEIIELDEHIDVDELRNTSRVLFRRTIRATAPGLRRFLYAFECPPDSGLRRVVVDPRGTVRVPRVIRVGEGSYVFHLEFADALAVDEAHSFEFAITTVENRNREPRGIYGKRQFVTTRVVRLSVGFSPKAHPHRVRWFAAPFPIGHFPDGYSFPEGNVLPQGEDGRYSNTFDQDALAPERIVGLVWDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDC5</accession>
    <name>F4FDC5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47336">
        <property type="protein sequence ID" value="AEB47336"/>
        <property type="gene ID" value="VAB18032_01260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01260"/>
    <dbReference type="HOGENOM" id="CLU_3159099_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="48" mass="5188" checksum="C61AECBFBB2E1C27" modified="2011-06-28" version="1">MSAHRLGRLLGSLLLVSGLVVAVGVASEFEVRTHGIEWMMPLLGTQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDQ3</accession>
    <name>F4FDQ3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731089.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06460"/>
    <dbReference type="EnsemblBacteria" id="AEB42416">
        <property type="protein sequence ID" value="AEB42416"/>
        <property type="gene ID" value="VAB18032_06460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06460"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_0_1_11"/>
    <dbReference type="OMA" id="YVYYQHE"/>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="369" mass="39189" checksum="BEE36667D25B6170" modified="2011-06-28" version="1">MSDPALLTSAAGLVPDVARIAVLRANALGDFIFVLPALDALRSAYPQAEIVLLGAPWHAQLWRDRPGPVDRVLVVPPAPGIRAAGPGEAEASMVDFLAAARTERFDLALQLHGGGANSNPLVAALGARVSAGLRAEDAPPLDRWLRYVYYQPEVIRYLEAVALVGAPATTITPTLTVTDADRAEARSVLGAAERPRVVLHPGATDTRRRWPAERFAEVARTLHADGYEVLVTGTPTEQNVVDQVVAAARVPLRPQVGTLSLGGLAGCYADCELVVSNDTGPLHLAAAVGTPTVGIFWVGNLITTATPLRARHRPITSWTVHCPVCGVDCTPGIYPHRPGDGECPHRDSFVTDVPVAEVLEAARELLFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDQ9</accession>
    <name>F4FDQ9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731095.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06490"/>
    <dbReference type="EnsemblBacteria" id="AEB42422">
        <property type="protein sequence ID" value="AEB42422"/>
        <property type="gene ID" value="VAB18032_06490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06490"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="OMA" id="FLTAHRC"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="336" mass="34953" checksum="841D3767BEAE1251" modified="2011-06-28" version="1">MKAIVYERTGDPSVLQLVDRPLPEPGAGEVLVRIVFSGVNPTDWKARRQWPLPAGWQTPGQDGAGIIEAVGAGVAQDLIGERVWIWEAAWQRPWGTAAEYTVVPVRQVVRLGDGSFELGASLGIPFLTAHRCLTAGEYLPDGLRPGALSDHAVLVQGGAGAVGNAAIQLAAWADACVIATVSSAEKAQLAAAAGASFVINYREQDVVAEVRKVAPDGVHGIVEVAAARNAATDVQLLHPGGVVCVYADDGGDEVTLPIRPLMTPNARWQFVLVYTLPKAAKAQAVMDVAAAAAQGGIRVGEEAGLPLHRYPLSAAAAAHQAVEDAVVGKVLISAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDR0</accession>
    <name>F4FDR0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06495"/>
    <dbReference type="EnsemblBacteria" id="AEB42423">
        <property type="protein sequence ID" value="AEB42423"/>
        <property type="gene ID" value="VAB18032_06495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06495"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_1_11"/>
    <dbReference type="OMA" id="MGVWDQV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="23431" checksum="8AD441108D583CFE" modified="2011-06-28" version="1">MMVEAVVFDLDGVIVDSEPVWEEVRRAYVAAHGGTWQADTQRRLMGMSTGEWARYLSGELGVRRSAEQVAAEVVEEMAQRYAQRVPVIDGADQVVRRLAARWPLGLASSSPTRLIAAALAATDLTDEFQATLSTEQTERGKPAPDVYLAVARQLGVDPTRCVAVEDSSNGVRSAATAGMTVVAVPHGSYPLDPDAQQLAATVLNSIDELTPQVVDRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDR1</accession>
    <name>F4FDR1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731097.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06500"/>
    <dbReference type="EnsemblBacteria" id="AEB42424">
        <property type="protein sequence ID" value="AEB42424"/>
        <property type="gene ID" value="VAB18032_06500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06500"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061724_0_0_11"/>
    <dbReference type="OMA" id="GYWRGYF"/>
    <dbReference type="OrthoDB" id="1438002at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="30623" checksum="CAA3B590C248C0D4" modified="2011-06-28" version="1">MWTCFEPVHAVTYFHPRARAAYEAVGLRGYWRGYFAGRAAPLGPVGPAPVVAAFYTFAPHMVTRALPSIWQLADPDQALRARLTGAVQALAELTYELPERHLAETAELLEVAAEGLGAAPGRVLGAANAALPRGDYPLARLWQAATTLREHRGDGHVAALVAADLDPVETLAWRVANGMPAQSLQGRGWSDHEWAQAQSRLAARGWLTPADPSTTPTTLSSATPTAEGRVAFQAVETATDTAAARPWHSLTPDTLTRLHTLLLPIAQAAHLVIPSTNPIGLPTPQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDS5</accession>
    <name>F4FDS5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732275.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12460"/>
    <dbReference type="EnsemblBacteria" id="AEB43606">
        <property type="protein sequence ID" value="AEB43606"/>
        <property type="gene ID" value="VAB18032_12460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12460"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_4_11"/>
    <dbReference type="OMA" id="YRDKVGF"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="135" mass="14633" checksum="F68A6B77EA32A1AC" modified="2011-06-28" version="1">MNWTLEVVVVPVSDLDRAKAFYAERLGFTVDHDTVVNDDIRLVQLTPPGSGCSIVIGKGAVPQMPPGSLKGLQLVVPDLHKARTQLLERGVEVSEIQVMGENPRPVPDPLDNVGFIHFADPDGNAWAVQQISSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDV9</accession>
    <name>F4FDV9_MICM1</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_12630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12630"/>
    <dbReference type="EnsemblBacteria" id="AEB43640">
        <property type="protein sequence ID" value="AEB43640"/>
        <property type="gene ID" value="VAB18032_12630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12630"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017999_1_1_11"/>
    <dbReference type="OMA" id="VGHWYEH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="710" mass="76473" checksum="1BBBDEBC57029461" modified="2011-06-28" version="1">MATSAVRLATVARTLLKRLLVGRPFRSDRLKHTLLPKRIALPVFASDALSSVAYAPDEILLMLSIAGASAFVFSPWVALGVVVVMLTVVASYRQNVHAYPSGGGDYEVATVNLGPRAGVGVASALLVDYVLTVAVSVSSGVANLGSVIPFVATHKVLIAVSAVILLTAVNLRGLKEAGSAFAIPTYGFMIVIVGMILTGLVRIVVLGEDLRAPSADLVIAAEWHDTTGWAMAFLLLRSFSSGCAALTGVEAISNGVPAFKAPKSRNAATTLLMLGLVSVTMLVGIIWLARLTGLQFVEDPSQQIVAGPEGYVQKTVTAQLGETIFGSGSVLLFLVVGVTATILFVAANTAFTGFPVLGSILAQDRYLPRQLHTRGDRLAFSNGILFLAAFAIVLIVGFQAEVTKLIQLYIVGVFVSFTLSQAGMIRHWNRRLRTERDPQVRRRMLRSRAINTFGMAMTGAVLVIVLITKFLLGAWIAIVAMGVIYLLMLAIRRHYDRVAVELAPDDGRPVLPARNHAIVLVSKLHQPTLRAVAYAQATRPDTLTAVTVNVDDVDTRQLQTEWERRDVPIPLTVIDSPYREITRPILNYVAGVRRDSPRDVVTVFIPEYVVGRWWENLLHNQSALRLKGRLLFEPGVMVTSVPWQLASTAGKDLDRMDATLGRGPVRGPRAVPRSILPPSIAPVDPTPMNPVPVDPAPSGPGQQSSNGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDX0</accession>
    <name>F4FDX0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12685"/>
    <dbReference type="EnsemblBacteria" id="AEB43651">
        <property type="protein sequence ID" value="AEB43651"/>
        <property type="gene ID" value="VAB18032_12685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12685"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_0_1_11"/>
    <dbReference type="OMA" id="RHVTIDC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13679" checksum="C018D67ECA1F038B" modified="2011-06-28" version="1">MRWIDFDCADPFAMATFWSEATGMRHDPDNKPGEPECALLSGAEIAEGGLLFQRVPEGKTAKNRVHLDLQPTDRTRDEEVDRLLGLGAVLIDDQRRPDGTGWAVLADPEGNEFCVERSAAEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDZ7</accession>
    <name>F4FDZ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733521.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18820"/>
    <dbReference type="EnsemblBacteria" id="AEB44866">
        <property type="protein sequence ID" value="AEB44866"/>
        <property type="gene ID" value="VAB18032_18820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18820"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="PERMNFY"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="32724" checksum="8CF31CC767BA8A50" modified="2011-06-28" version="1">MTTDPIVQAVELTKVYETRRALDDLALRVQPGSRFVVLGHNGAGKSTLLEIIATLRVPTSGSVRVGGFDTVRQPREAGRLIGLAPQSNALDPLATPTEVLDFQAVALGLGRRQRTRRTRDLLDLFGLGEHRASRVATLSGGTCRKLDLAVALVAEPTLVILDEPTTGLDPLARIDFWAELTRLNSDGTTLLISTQDLHEADVLATDIAVLREGRVVAQGTPAALKQRVGTRTLTLDLSTDAASAALVSSSRVGFLPDDHGNRVRLGISDDPAALRDALTEISGVAGEITGLHLSEPSLDDVFVALAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE05</accession>
    <name>F4FE05_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, atpase, winged helix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733529.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18860"/>
    <dbReference type="EnsemblBacteria" id="AEB44874">
        <property type="protein sequence ID" value="AEB44874"/>
        <property type="gene ID" value="VAB18032_18860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18860"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_5_0_11"/>
    <dbReference type="OMA" id="PAWAWVE"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1040" mass="109856" checksum="6AA4A80E0680E27D" modified="2011-06-28" version="1">MQFRVLGPPEVVRDGQVVPLGGPKQRALLVLFLLRPNRFVAADWLVDALWDGRPPPSADITLRTYVAGLRRAVEPHRSPREAARILRSRSKGYELRVDPDSIDATRFRQLVDRAAERLSAGEPAAAERDYHDALRLWRGEPMTGAAELAAVRPEAARLAELRLIAEEGRFTAAVAAGRHATVLAELRQFVAAHPVRETARAQLMLALYRAGRQTEALATYDEGRRILVDEYGIDPGAHLRELHTLILEQAVSPGASASPVPAQVGTGSRLVPVGSGDPAGALVGRGAELARLVAALAGATREHGRSAIVVGEPGIGKTSLAATVGAVARADGVAVVWGHCPDLGQAPPFWLWRQVVRGLVAMPQVGASGTVRGLDGFAAGPAHDATGEVSPDPAARFQAYEAVAELVRAAAEPAGLLIVLDDLHAADPDSLLLLRFLTTALPGTRALVLATLRPYEHDAALVATVAELARGPGFGRLRLTGLTSDAVADLVRRRTGAPPAGPALARLVTRTGGNPFFITELLRARADPAGTDLPPSIRDTVRLRLGGLPAATRDCLALLAAAGDDLDATTMAEVLELPADAVAEALSAAYTAELVTEAEPGGVRFRHPLFAEVAYAELPPPRRATLHARLAGVYERSGVVGPAELARHYGQAAGLGHEAEHLRWSLAAADDATRRFAYEDALGHLNRAAHRLARAVGSATAARTELDVQLHRAALLQMTVGVGADAVDQVCARARELLALVGPDTDVRPALWALGELAANQADYAGCTDLAERLCQAGTGTGTDELTVAAGEYLLGVIGYFTGRLDKADQRLTAAIDRLGAVDSRLLGRQVGRLPVLAAHNFRALVRSLRGDPVAARRDIRDAELLAERLDDPYGRANAALFAAWTGLQERDVPMVRAAAARCQEIGAANGMPHFVATGGFFREWADARGGAPERLAAMRVAVEGIYRPGLRATRTVTFTAMAEAYLAAGDRDTAAALAQDGLAVVDRLGETVFAAELHRIRGIARDDPAALAAGARLAEEQGAELLLARFPPQLGGQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE35</accession>
    <name>F4FE35_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_19010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19010"/>
    <dbReference type="EnsemblBacteria" id="AEB44904">
        <property type="protein sequence ID" value="AEB44904"/>
        <property type="gene ID" value="VAB18032_19010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19010"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_4_11"/>
    <dbReference type="OMA" id="HANDEMV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="945"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1023" mass="107897" checksum="FC741983F5630F0B" modified="2011-06-28" version="1">MGTAEATYAQHAVWFTEQAGTAGTAYHMALGVRFGAELDTQSLVAACTSVIERHPILSARITGDDDGTPRLAPADTRPSVGFGDLTDARIAEEIARPFDLQAGPLARFTLLTGVGGEYLLLVTAHHVAFDGTSKDVLARDLAAAYAAARAQEPTDLPARADDYSGLAAAEQQRIAADLPAARDYWAGHWSGPGDLVLPGLRRLPTAAEPGVAVAADLPAELVDGVDRLARTLAVTRFEVLFAALHALLARYGNLGVPVGVALSTRTPEQADLVGLFVNELPVAADTATATFRDHAQALRARLREVYRHRAVPLAHAVPGLRPAPALTPVSVGYRRRAAEPVFPGVPSQVEWTLFSGAARNALHVQIVDAPTGITVSLHHSPTAIDTDAVRRIGGHLHTLLAAVIADPDRPVARLPLLPADELDQVTRAGTDTTRSCPAATVPDLFAARVAADPDAPALVDGDLTLSYRRLDEASRRLAGALRQRGVGPASLVAMPLERSWQAVATMLAVLRCGAAYLPIDPAHPAARQEAVLTDAAPTLVVTATGTASDRPTLALTDVALLDGPLPTEPDERPGVDDLAYVLYTSGSTGRPKGVAIRHGSLANMLFGVRDLLGSGPTHRWLHLTSLSFDISTVEVFLPLVTGGQVVVASTVSALDGPAVLALVRSAGVTHAQATPSGWRVLLEAGLGAPGDPTPPLVAVAGGEALPVTLARELRARTTRLINGYGPTEATVYATMADIPADPVDVTIGTALPNVRAYILDTAGLPTPVGLPGELHLAGAGVALGYLGRDDLTAQRFVPDPYSPVGERMYRTGDRCRWRPDGHIEFLGRTDHQVKIRGHRIELGEIDARLLDHPGVAEAVTVLRQDTDEPRLVAYLVPRPGGVPESADLRHHLASSLPQAALPSDYVILDRLPLNANGKVDRAALPAPTARPTAVAAGPVGAAGPVDDDPLVAQLRLIWQEVLRIPDIGVHEDLFDLGGHSLTITRISGRIQQRLGVDVPLDAFFDTPTIAEIADIVRQVRKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE82</accession>
    <name>F4FE82_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734800.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25250"/>
    <dbReference type="EnsemblBacteria" id="AEB46148">
        <property type="protein sequence ID" value="AEB46148"/>
        <property type="gene ID" value="VAB18032_25250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25250"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_11"/>
    <dbReference type="OMA" id="HSCGNRI"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="189" mass="19643" checksum="BD09AFDCA1138A48" modified="2011-06-28" version="1">MTAAQRADARRNYARLLAVAVEEVAAHGADASLEQIARVAGVGSGTVRRHFPSRHALLAAVFRERVEALATHAADRTERADPRAALLEWLQAVIASATTISGLAEALNRDRVAGPDDTHVYCACAQLTAAGEPLVRRASADGALAPGVTIDDLLTLITGIALATTHHPDPAAAAARLLDLAITGISPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FET6</accession>
    <name>F4FET6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding region atpase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731153.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06780"/>
    <dbReference type="EnsemblBacteria" id="AEB42480">
        <property type="protein sequence ID" value="AEB42480"/>
        <property type="gene ID" value="VAB18032_06780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06780"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072253_0_0_11"/>
    <dbReference type="OMA" id="TWDWWAR"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="205"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="348" mass="37097" checksum="B2A3B9ABB20D99A1" modified="2011-06-28" version="1">MRTGPAAAESGYFHEALCYASDDELLAVAVPFLLDGVTAGEPTFVALGERTGGLVRSALPADSGVEFLTGAEVYARPTAAIRMYRKLLADLTAGGADQIRIIGEVPPPSLGSTWDWWARYEAAINRAYDDWPLWSMCAYDTRITPPDVLADVAATHPHIATARQRHLPSPDYLAPESFLRQNRPAPPDPIQAYPPLLQLTDPTAAQARSAVHQAGPGQLSAEDLDDFVIAVSETVTNGLRHGSPPVRLRLWTAPDRIVATVSDTGKGPDDPYAGLLPPADGRPGGLGLWITYQSCNHVTYHRDADGFTLRLTAGQPPGLTAVAQSEPPGGERRPGGSGDQQLSSGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FET9</accession>
    <name>F4FET9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06795"/>
    <dbReference type="EnsemblBacteria" id="AEB42483">
        <property type="protein sequence ID" value="AEB42483"/>
        <property type="gene ID" value="VAB18032_06795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06795"/>
    <dbReference type="eggNOG" id="COG5660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081592_0_0_11"/>
    <dbReference type="OMA" id="GCEQWRE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="32380" checksum="961F6834DDCACFB9" modified="2011-06-28" version="1">MAADQAPGRPAGNHADLTSDYRYMGCEQWREILSAQLDGEATPDEERAADGHLETCTACEGWYSRAATVTRRARTQVVSALPDLTEAILSAAPPPRRRARTPIAALRRQRWFAAFAGRITAVTALRAALGLLGAVQLVLGLAQVGRAEVTQHVHANGQHLWHESAAWNVAVGAGFLFVALRRTRPSGLLPMLSAFVATLVLLSINDLVASQVAVERLVSHGFLVVGYLITVLLARSVRQPGDPNDRQRPERSRWRLRLDETDEPATLRLLPPYSAQAHHPTQAQAHHGPQQASRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEY7</accession>
    <name>F4FEY7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732367.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12925"/>
    <dbReference type="EnsemblBacteria" id="AEB43699">
        <property type="protein sequence ID" value="AEB43699"/>
        <property type="gene ID" value="VAB18032_12925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12925"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_2_3_11"/>
    <dbReference type="OMA" id="ACPPWML"/>
    <dbReference type="OrthoDB" id="534010at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309304" evidence="1">
        <location>
            <begin position="26"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="429" mass="46533" checksum="069ADFFF5F5F8360" modified="2011-06-28" version="1">MNLTKRRARLAAATLAAVTAVGGLAACGNDDDNTSAEGGKPAKLVVDTFGEMGYDELVKQYEQQTGIKVELRKTAQLREYRPKLVRYLATGKGAADVTALEEGILNEFKANPRNWADLAPLIDDHSKEYLPWKWELGKAPDGRLIGLPTDVGSLAVCYRKDLFQAAGLPTERDQVSALWPDWNGFHQTGQKYKQATGKGFIDSITAVSNGVLFQQGSDLFYDKENNVIAKDSPAVKAAWDTATSMVDISAKAETWSPAWNAGFKQGTFAATFCPSWMLGIVEENSGEGNKGKWDVAAVPGGGGNWGGSWLAVPEQSQHQKEAAKLAEFLTNATSQVAAFKATGPLPTNLEALKNEEFLNYTNEYFSGAPTGKIFGESVAKIEPVHLGPKHQAVKENAFEPAMRAFENGRASKDQAWEQFTKDAETQGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF11</accession>
    <name>F4FF11_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13045"/>
    <dbReference type="EnsemblBacteria" id="AEB43723">
        <property type="protein sequence ID" value="AEB43723"/>
        <property type="gene ID" value="VAB18032_13045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13045"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="OMA" id="RIFIIDG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="199"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="32516" checksum="DAB7E680436CD31E" modified="2011-06-28" version="1">MLHFELGLAYEVFGSKPDVVPGPWYDVRVCGTATVRVGRFLLEPDCGLDRLADAGTVIVPALADVDEEPPADLVEAVRAAHASGARVVSLCTGVFVLAAAGLLDGLCATTHWAHTVQLATRYPLVKVDPDVLYVDNGSVLTSAGKAAAMDLCLHLVRRDHGSAIANVVARRLVVPPHRAGGQAQFVTTPVPAHDDHPLATLLPWVMRRLDQPLTVEDLARQANMSSRHLARHFHAVTGTTPLQWLLTQRIRRAQELLETTDDSIDTIASTAGMGTATTLRRHFQRTVGVPPDTYRRTFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF45</accession>
    <name>F4FF45_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Htaa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733605.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19240"/>
    <dbReference type="EnsemblBacteria" id="AEB44950">
        <property type="protein sequence ID" value="AEB44950"/>
        <property type="gene ID" value="VAB18032_19240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19240"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044067_0_0_11"/>
    <dbReference type="OMA" id="GFKASFR"/>
    <dbReference type="OrthoDB" id="1213925at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007331">
        <property type="entry name" value="Htaa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027273">
        <property type="entry name" value="Neocarzinostatin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04213">
        <property type="entry name" value="HtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49319">
        <property type="entry name" value="SSF49319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309307" evidence="1">
        <location>
            <begin position="37"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="HtaA" evidence="2">
        <location>
            <begin position="43"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="504" mass="50069" checksum="2A2D7B6360094303" modified="2011-06-28" version="1">MSVPRPGGVRRRSYRWVTAAVLGAAASLAVVVPATAAPADVTGGSLDWGFKSSFRAYVSTGNGNPPIAVTDGATRNADGTFKFPATGGTYDSATGATTVNYGGTVVFSYPAHFFTITLANPTVVLDGTGGSLLADVDLQTSGGGFEPVRIEQAAIATLATASPSVSGGTVSWSNLTTTLTETGASAFSGFFTAGTVLDPASFTLTTAAGGGGAPAAPSVTVSPSAALDPEGATVTVTGTGFDPEANGGVGFYLAFGPKGENYWTNSRPYKPVKWVHKNASSSAAQVRLPADGSFSTTLDLVPTYTDGNGNTVDCTAIQCYVMTFAAHASSDRSQDTFTPITFGGTGGPSGAEQEITAEVLQSGPLTLTASGNSVALPAVHPGAFADSSLNAVTVSDLRGTNAGWNVVGQVEEFTSALGGTIAAENLGWTPHASVLADTLVGAAGVVNPGAPATPGDGLGSARTLCAAPAGTSAGSFQCGADLRLGVPPAAVPGGYTATLTLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF73</accession>
    <name>F4FF73_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, badm/rrf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733633.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19380"/>
    <dbReference type="EnsemblBacteria" id="AEB44978">
        <property type="protein sequence ID" value="AEB44978"/>
        <property type="gene ID" value="VAB18032_19380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19380"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_1_11"/>
    <dbReference type="OMA" id="FDIAYNA"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="15882" checksum="87510D53618E0C27" modified="2011-06-28" version="1">MYVSARSDYAVRAMLAMAQQHPALVKAAALAASQDIPYSFLQGILLDLRRAGLLHSARGSDGGYALTRAPEEITVGDVLRATGGPLTTVRGAPAEVATYHGVAVGLGEVWQSVHRAIERVVDRSSLADLLVPVDRPADAHAGRVCTRSGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFH2</accession>
    <name>F4FFH2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_25880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734925.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25880"/>
    <dbReference type="EnsemblBacteria" id="AEB46274">
        <property type="protein sequence ID" value="AEB46274"/>
        <property type="gene ID" value="VAB18032_25880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25880"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OMA" id="AQADKMR"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="328"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="360"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="534" mass="57282" checksum="BEFC75E540676C18" modified="2011-06-28" version="1">MITATGLELRAGARILLSDTTLRVQPGDRIGLVGRNGAGKTTTLKVLAGEGQPYAGQVDRRSPVGYLPQDPRTGDLEVTGRDRVLSARGLDALMAGMKDLEAKLADGGDEKLVRRYGALEDQFAALGGYAAEAEAARICANLGLPDRALAQTIGTLSGGQRRRIELARILFRDAGDDGGGILLLDEPTNHLDADSITWLRGFLANHKGGLVVISHDGDLLESVVNKVWFLDATRSVVDVYNLGWKAYLEARETDERRRRRERANAEKKAGALMAQADKMRAKATKTVAAQNMARRAERLMSGLEEVRVSDKVAKVRFPAPAPCGKTPLTATGLSKSYGSLEIFTDVNVAVDRGSRVAILGLNGAGKTTLLRMLGGLLEPDTGEVHPGHGLRLGYYAQEHETLDVQRTVLENMRAAAIEQTDTELRKILGAFLFSGEDVDKPAGVLSGGEKTRLALATLVCSGANVLLLDEPTNNLDPVSREQVLDAIARYPGAIVLVTHDPGAVLALKPDRAILLPDGDEDAWSDDLLELVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFK5</accession>
    <name>F4FFK5_MICM1</name>
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        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01990"/>
    <dbReference type="EnsemblBacteria" id="AEB47482">
        <property type="protein sequence ID" value="AEB47482"/>
        <property type="gene ID" value="VAB18032_01990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01990"/>
    <dbReference type="HOGENOM" id="CLU_3031193_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="6064" checksum="0AF5406BA3828B78" modified="2011-06-28" version="1">MLVAVPDISETFTPLSLVTGRHINRSTDRSGQPEPNEIIYSWSIPHRPAAATLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG09</accession>
    <name>F4FG09_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">VAB18032_13195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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    </dbReference>
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        <property type="gene ID" value="VAB18032_13195"/>
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    <dbReference type="OrthoDB" id="1975371at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13637" checksum="27B5DD7891E0C604" modified="2011-06-28" version="1">MSTQAASTRPMNRPAQDVQHRQAMQDMPTRQMPAYDGHREPAQAPGTETKQSFLTTEFWIYAAAVAAVVIAAFWRGTTANGLNLNNPGQAWFFITLLTLGYLGSRGLAKAGSPKRSGEERKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG31</accession>
    <name>F4FG31_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43775">
        <property type="protein sequence ID" value="AEB43775"/>
        <property type="gene ID" value="VAB18032_13315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13315"/>
    <dbReference type="HOGENOM" id="CLU_3223542_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="44" mass="4712" checksum="6234664488918CC4" modified="2011-06-28" version="1">MTSYDTRSDRPAVSYKRGVNLLQVIGSMVGLCLVLVVMPVVGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG34</accession>
    <name>F4FG34_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_13330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732445.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13330"/>
    <dbReference type="EnsemblBacteria" id="AEB43778">
        <property type="protein sequence ID" value="AEB43778"/>
        <property type="gene ID" value="VAB18032_13330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13330"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049732_0_0_11"/>
    <dbReference type="OMA" id="QVDAGMW"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307882" evidence="2">
        <location>
            <begin position="41"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="4">
        <location>
            <begin position="51"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="260"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="387" mass="40598" checksum="B273BC4338FDBB4A" modified="2011-06-28" version="1">MYASIGGSRRPSAPRKSRLTVRLAALASTVALSATGLAVAATPSSAAVCNGYVGITFDDGPNSSTSALLSVLRANGVRATMFNVGQNVQSNPSAARAQVDAGMWVANHSWNHAHMTSMNQSQMQSDLSQTNSAIQAATGVRPQLFRPPYGETNSTLQSVASSLGLRQVIWDVDSQDWNGASVSQIVSNASRLQAGQVILMHDGIQNTRNAIPQIMANLSSRNLCPGMISPSTGRAVAPDGTPPPTTPPPTSPPPTTPPPSGSASQIVGSQSGRCIDVPNASQNNGTRVQLYDCHGQTNQAWTYTSDKQLRVYGNMCLDAAGSGNGAAVQIYTCHSQSNQQWNVNSNGTISNVQSGRCLDAWSTANGAQVQLYDCHGGTNQRFSLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGF3</accession>
    <name>F4FGF3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_19945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M15D family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19945"/>
    <dbReference type="EnsemblBacteria" id="AEB45091">
        <property type="protein sequence ID" value="AEB45091"/>
        <property type="gene ID" value="VAB18032_19945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19945"/>
    <dbReference type="eggNOG" id="COG2173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060744_0_1_11"/>
    <dbReference type="OMA" id="EWWHFTY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="30934" checksum="B147E9A71341C6AC" modified="2011-06-28" version="1">MPRAAPRPRAADQKMAGWSKGLVGLTVGLVTVAGCGRPQPNPPPSTAPPPSLPDFVVLSDVDPRILTDIRYAGPHNFVGRPVTGYPEPLCLLTTQAAEALRRVQDAALATGHTLKVYDCYRPQSAADEFVAWARRPDEEQMKAEFYPRVAKSDLFDQGYLGAPTAHSRGSTVDLTLVDLPARQQAGYLPGQPLVACTAAQPQRFGDNSVDMGTGFDCFDPLAHTDSARVSPTARENRRLLHRLMTDGGFVGYDREWWHFRYRDEPWPDTYFDRPVARSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGI4</accession>
    <name>F4FGI4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol-dependent maleylpyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734970.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26105"/>
    <dbReference type="EnsemblBacteria" id="AEB46319">
        <property type="protein sequence ID" value="AEB46319"/>
        <property type="gene ID" value="VAB18032_26105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26105"/>
    <dbReference type="eggNOG" id="ENOG5031RF6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077935_0_0_11"/>
    <dbReference type="OMA" id="PFRRWVE"/>
    <dbReference type="OrthoDB" id="1548598at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="25735" checksum="B422B35D666097A3" modified="2011-06-28" version="1">MTTDPLLLTGDVDDATTRLIRTAARFDAADLAQPSLLPGWTRGHVLAHLSRNADALVNALTSARTGELIPMYASAESRTADIEAGAPRPPDEQLDDLRRSADRYAEAVAAMPAPAWAATVQTRRGPLPASLLVWRRLREVEIHHVDLAADYRPRDWSPTFGHRLLHEVATDLAARDDAPALVLRFDGTSHELVIGDRAQAPVVSGPAVEIAAWLTGRSPGATLTVTPDGQLPHPPEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGK3</accession>
    <name>F4FGK3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734989.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26200"/>
    <dbReference type="EnsemblBacteria" id="AEB46338">
        <property type="protein sequence ID" value="AEB46338"/>
        <property type="gene ID" value="VAB18032_26200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26200"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049749_0_1_11"/>
    <dbReference type="OMA" id="VWCPEGL"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="69"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="268" mass="29771" checksum="73A8C4FFF7B5D296" modified="2011-06-28" version="1">MDDDNRVTRRRVDDTEARRANRHWWDADADAYQAEHGHFLGEVDFVWCPEGLREADARLLGEVAGRRVLEVGCGAASCARWLATEGARPVAVDLSAGMLRHAVQAAERTGVRVPLAQADALALPFRDASFDLACTAFGAVPFVADSAALMREVHRVLRPGGRWVFSVTHPMRWIFLDDPGEGGLTAVHSYFDTRPYVEQDEQGAASYVEQHRTLGDRVRELVGAGFRLLDLVEPEWPEGHEGIWGQWSPLRGRLFPGTAIFVSEKPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGT1</accession>
    <name>F4FGT1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02535"/>
    <dbReference type="EnsemblBacteria" id="AEB47591">
        <property type="protein sequence ID" value="AEB47591"/>
        <property type="gene ID" value="VAB18032_02535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02535"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_14_1_11"/>
    <dbReference type="OMA" id="SVFMIGE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="432" mass="43875" checksum="37DC9BB854CA9617" modified="2011-06-28" version="1">MTDTRTPTVERPATFGDVFAVAEFRVIFGSFGIFMIGETVKMLALSVLVYERTGSGLLAALAYVTGFLPHALGGVFLLALADRMPARALIVGYDLLRLAVVVVLATGALSPPLMLGLVAVVALFGPVSSAARTALLPEVLHGDSYVLGRSLLSVAAGGTQVAGFAVGGLLLGLVGPYGALWLTALTCGLSALLVRLGLTRRPARVRTSPATDAVSTGAVGPATGAVGTAAGRGRGGAVRETLRVNRELLADRRIRGLLLAQWLPGSLLVGAEGVAVPYAAELGPGASAGVLLMAGAGGMLVGDLLVGRFVAPARRERWTPWLALLLGVPMLAFLAGPGLLPAAALFAVATAGFAYQLGLARRFLDAVPELRRGQAFGLVSTGMMAMQGLAAAGAGGLSEWLAPGVVMAVAGAASIAATLALWPVLKPAAHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH09</accession>
    <name>F4FH09_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_07515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07515"/>
    <dbReference type="EnsemblBacteria" id="AEB42623">
        <property type="protein sequence ID" value="AEB42623"/>
        <property type="gene ID" value="VAB18032_07515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07515"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013918_1_0_11"/>
    <dbReference type="OMA" id="AIGWAHA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="389"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="3">
        <location>
            <begin position="636"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="794" mass="85582" checksum="E8B2B23CD97CA4E9" modified="2011-06-28" version="1">MWAAQRPWLAAVAAGLLAAWIAARNLVEIWRHHHHAHDARLVTIAPPPEVDPHSAAALWANLAGVLTPSRRRRLLHGTPHVVWQYTWSGRQLLISIWVPGTVPPGAVEAAVRAAWPGSATTTDDNPPPPIPLDAHPAAGGHLLPVYAEWLPLTSDHDTDPLRPLMSAGAQLKPGEYACVQVLARPATPRRAARARRAAGRLRAGKTAVPALNPAAPVLWLLEAFLPGSGNTGRPTPVARRDPTVERDVRAILDKTAHPLWQTGIRYAVATTSRRPGADPRGRLRGIADTLASAFAIHTGRNRLTHRARMPAPVAVLAARRLGPGFLTSAPELAALAALPRDLAVPGLDRARAASMPAPVAVPGGGRGVKMLGDAEIGGHAVGLAVPDARYHLHVIGSTGSGKTTLLVNMALDDIKAGRGTVVIDPHGDLVLDILDRLPATVADRVVLFDPDQDNPPTLNPLEGDDPDLVVDNLVSIFGTIFAKAWGPRMDDVMRVACLTLLRHNNVTLQHIPPLLNSPQFRSAMTVDLDDPAGLSGFWQWYDSLNDSLRSQVIGPVLARLRAFLLRDFVKRTMRYPKSSFDMGRVLDGGVLLVRIPKGVLGEDTSRLLGSLILAQVWQATTARAATAPEKRRDASLIIDEAQNFLTLANSLDTMLAEARKYRLSLVLAHQDLAQFPRDLLAAASANARNKVYFTCAPEDAKVLSRHTLPELGEHDLAHLDAYTAAARLVVNGRQTPAFTMKTRPPRPVVGEATAIRQAAAAAVPAQDTSAVDELVERLSRKPDQRRSRPKSDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH98</accession>
    <name>F4FH98_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732543.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13820"/>
    <dbReference type="EnsemblBacteria" id="AEB43876">
        <property type="protein sequence ID" value="AEB43876"/>
        <property type="gene ID" value="VAB18032_13820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13820"/>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979389_0_0_11"/>
    <dbReference type="OMA" id="GWHSFPG"/>
    <dbReference type="OrthoDB" id="1441395at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="129"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="29456" checksum="D408780A854ED735" modified="2011-06-28" version="1">MKHTLKRQLRKLATERPYQLLATSAAALVLATGAGALVARTDDNLVDAPTAAAVAELRDDSAASRSLARVATAPSSAAPSSAAPSSAAPSSAAPSSAAASPSARAATADPDVASKKAAPKPPAEKVLSYDYQAQINGYYCGPAAVRNALSAAGIERGQETLAAQLGTTFAGTNSAYDTTRALNAAVKGEPYKTTMIPGGSATPAQMDQLQADVVAAISDGRGVVVNVAGSVVDTAGGWHSFPGGHYVAVVGYEDEGRMVKIADSADASYYSYWLSTIDLANWAATRGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHD2</accession>
    <name>F4FHD2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Degt/dnrj/eryc1/strs aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13990"/>
    <dbReference type="EnsemblBacteria" id="AEB43910">
        <property type="protein sequence ID" value="AEB43910"/>
        <property type="gene ID" value="VAB18032_13990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13990"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_2_1_11"/>
    <dbReference type="OMA" id="RFWATQA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="378" mass="39878" checksum="3B2AA7FCA9F0675E" modified="2011-06-28" version="1">MHLSPPDIGPLEESYVIAALRSGWVAPAGPDLDAFESEVAARVGTRSAVAVSSGTAALHLALLAVGVSPGDAVLVPTLTFVATANAVRYTGARPVFVDCDPHTGNVDVSLVVELLNRLRTRGERVGAVVPVDMFGSCVDYGELLPACAASGVPVVEDAAEALGAMHRGRAAGSFGRVGALSFNGNKIMTTSGGGMLVSDDLPLLARARHLANQAREATVHYEHRETGYNYRLSNLLAALGRAQLIRLDEMIGRRRQLRDRYAKLFAPVPGVELLGANDPASNCWLTVIRVRPELSGWKVAELAAHLADRNIETRPVWKPMHRQPAYAGSECLLTGASDDLFAEGLTLPSGSALAERQVGAVFGAIDEFLTSRAGASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHJ9</accession>
    <name>F4FHJ9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733826.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20355"/>
    <dbReference type="EnsemblBacteria" id="AEB45171">
        <property type="protein sequence ID" value="AEB45171"/>
        <property type="gene ID" value="VAB18032_20355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20355"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_13_1_11"/>
    <dbReference type="OMA" id="VCGFEHG"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="22075" checksum="3E2856FAB7F1DD48" modified="2011-06-28" version="1">MGQITLIRHGATTWSTARRHTSYTDLGLTPDGERQARSLRPALAAERFVAVLSSPRLRAVRTADLAGLTITDTDEDLAEWNYGEYEGQTTAEIHEDQPGWSVWTDGCPGGESPSEVGERVDRLLSRLHPLLDKGHVALVGHAHSLRVLGARWVGLPPSAGGLLRLDTATLSLLGTEHGRRVILRWNHPPAPPVDAVDATTARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHK9</accession>
    <name>F4FHK9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733836.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20405"/>
    <dbReference type="EnsemblBacteria" id="AEB45181">
        <property type="protein sequence ID" value="AEB45181"/>
        <property type="gene ID" value="VAB18032_20405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20405"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036703_0_0_11"/>
    <dbReference type="OMA" id="DVAHCPY"/>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="359"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="526" mass="56202" checksum="FB10777D074186E2" modified="2011-06-28" version="1">MDDRYDVVVVGGGAAGLAGALTLARARRSVLVVDAGEPRNAPAAGVHNYPGREGMPPAQLAAISRDEVAGYGGQLVTGRVTGVDRDGDEFTVTVDGGRTVRARRLLVTTGLVDELPPLPGLAKRWGRDVLHCPYCHGWEAADRRIAVLATGPLAAHQARLWRQWSADVLLLLHHEPAPDAEEAERLAALGVAVVPGPVAELTVDADQVTGVRLASGEHVECDVLVAGPKMTARSELLGSLGLAAEPVEMFGHVLGEQVPAGPSGATSVPGVWVAGNVADLSAKVIRAAGAGITAAAAINADLMEEDTRQAVARHRRVREEAFTEAGWEQRYQERPAVWSGRPNPQLVAEAAELTPGRALDVGCGEGADTVWLAERGWRVTGVDISKTALQRAAQHAREVGEQVAQRIEWVHTDLLRGELDEGAYDLVSAQFMHLPPQPRRELYARLAAAVAPGGRLLIVGHHPQDLRSTAHRMHYPEMMFTAEQVAADLDPQQFEVLVAQTRSRGAVDPQGRDIVVHDAVLVARRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHL0</accession>
    <name>F4FHL0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="10" type="ordered locus">VAB18032_20410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20410"/>
    <dbReference type="EnsemblBacteria" id="AEB45182">
        <property type="protein sequence ID" value="AEB45182"/>
        <property type="gene ID" value="VAB18032_20410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20410"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_0_1_11"/>
    <dbReference type="OMA" id="IPQSMKW"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="246"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="538" mass="56078" checksum="C3FC69EA0575F7DB" modified="2011-06-28" version="1">MTVPDSPVTTVDPVAAATPPSRLSPVRLPVALAMAVAAGLALLLAFPPYGWWPLAPVGVALLAAATHRRRLSAGAGLGFVTGVALFAPLLAWTNLHTGYLPWVLLSLLQAAYLALLGVATAWVSPLVDRFPPVWPVVTGVLWVGQEALRDRTPFGGFPWGRLAFGQDGSPLLRLAALGGAPLVTFAVAVTGGLLVAGLWWLARARRQPTAAPRWWVPAAGAGAAVLVLFSTALLVPLGGSARGGSVTVAIVQGNVPRLGLDFNAQRQAVLDNHVDATIELAAQVAAGAREQPDLVVWPENSSDIDPLRNPAAGARISAAADAVGVPILVGAVLSGPEQGQVRNAGLLWRPGTGPDLEQLYIKRHPVPFAEYVPMRDIARMVSKQVDRVRADFVAGTEAGVVRTPAVVLGDVICFEVAYDGLVRDTVTGGAQLLVVQTNNATFDVAEARQQLAMVRLRAVEHGRPALMASTVGVSGFVAPDGRVSDATGFNTRAVVVRQLTLTEGRTLATRIGMLPEVLLAGLAVAALAGAAVLRRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHT3</accession>
    <name>F4FHT3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
            <shortName evidence="3">Pol IV</shortName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dinB</name>
        <name evidence="6" type="ordered locus">VAB18032_26896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735103.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26896"/>
    <dbReference type="EnsemblBacteria" id="AEB46452">
        <property type="protein sequence ID" value="AEB46452"/>
        <property type="gene ID" value="VAB18032_26896"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26896"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_2_11"/>
    <dbReference type="OMA" id="CKPDGLL"/>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="26"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="3">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="45355" checksum="F85730093DDCC93E" modified="2011-06-28" version="1">MGRSQSLPRGGDPRFGPDADDTGCPILHVDMDAFYASVEVRHRPELRGRAVVVGGVGPRGVVSSASYEARQYGVRSAMPTMRARALCPHAIFLPPDFTRYTAASRAVMQIFRDVTPLVEPLSLDEAFLDVAGARRLFGSPATIGRRIRERVAAEQGLTCSVGVGPSKFVAKLGSTRAKPDGLLVVPAAQVLDFLHPLPVSALWGVGERSAEALLRLGLRTVGDLAQAPIGMLRTALGQAAAAHLHELAWGRDPRRVSPEQVEKSIGAEVTFDVDVDDPEHLRRTFLALAEKVGARLRDAEQVGRTVSIKVRMSDFRTISRSRTLEVPTDVAREIFDIAWSLFAALPSGEQIRLVGVRAEGLHRADATPRQLTLGEPERGWREAEVAADAAAARFGRSVIGPASLLSGRDTRRKENPTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHZ4</accession>
    <name>F4FHZ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736319.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03015"/>
    <dbReference type="EnsemblBacteria" id="AEB47687">
        <property type="protein sequence ID" value="AEB47687"/>
        <property type="gene ID" value="VAB18032_03015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03015"/>
    <dbReference type="eggNOG" id="ENOG5032YI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183720_1_0_11"/>
    <dbReference type="OMA" id="WEYVTVP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="51" mass="5817" checksum="84E0C998A5ED16F7" modified="2011-06-28" version="1">MQKWEYATVPLLVHATKQILDNWGEDGWELVSVVPGPNPEQLVAYLKRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI34</accession>
    <name>F4FI34_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
            <plasmid evidence="1 2">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30174"/>
    <dbReference type="EnsemblBacteria" id="AEB47998">
        <property type="protein sequence ID" value="AEB47998"/>
        <property type="gene ID" value="VAB18032_30174"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30174"/>
    <dbReference type="eggNOG" id="ENOG50323XT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2738930_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="71" mass="7530" checksum="920A6F23436FE22D" modified="2011-06-28" version="1">MWTGSPEPLRDLVDQAARAREGEDAQAIAMACWAVLVLIPRGLLHLASWVLAHPLRSLAAAAVAAVFVATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI64</accession>
    <name>F4FI64_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_30324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
            <plasmid evidence="3 4">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30324"/>
    <dbReference type="EnsemblBacteria" id="AEB48028">
        <property type="protein sequence ID" value="AEB48028"/>
        <property type="gene ID" value="VAB18032_30324"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30324"/>
    <dbReference type="eggNOG" id="ENOG5032TCD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796797_0_0_11"/>
    <dbReference type="OMA" id="PALMRFI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB48028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="348" mass="33093" checksum="4D5CD174AE1C9B29" modified="2011-06-28" version="1">MGALLVGAIRLAIERNGREAGSIAKGLAALVVITGVGVPAVQVLTVVGDAYSNWILTEAANKDLGARLLQLSPAAGASTLSPIMLIGVSLFIFMAAMVQLMMLLAQSAGLVLLAGLLPLVAAAGISGSGQAVRNRYLTWLIALILYKPAAATIYAAVFWLGQGKTLTDLLTGLVMFCMAIVALPALLRLIAPAVSVLSSGGGASGAGVAAVSAAGQIASGAVRLSNSSGGKGSGGGSGSRTGNSTDRPVGASPPVPSQRPSDGVAAGTSTSASPGAAGGAAAGSGAAAGTSADTNSAAPGTAARTGAAAAAGPVGLAVAGGLAGTQASQAPVRKVGGTASGAMDGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F155</accession>
    <name>F4F155_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42709">
        <property type="protein sequence ID" value="AEB42709"/>
        <property type="gene ID" value="VAB18032_07955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07955"/>
    <dbReference type="HOGENOM" id="CLU_2557352_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312596" evidence="2">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="82" mass="7937" checksum="4C342D08D9BA3CCA" modified="2011-06-28" version="1">MVGRILAFDLGHAALAVAAPFAAVAMLVMLGPLPRRASAARAAHRSPPGAAPPTAPAPLLLALVAAVTALAGLVGAVTVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F173</accession>
    <name>F4F173_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ordered locus">VAB18032_08045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731400.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08045"/>
    <dbReference type="EnsemblBacteria" id="AEB42727">
        <property type="protein sequence ID" value="AEB42727"/>
        <property type="gene ID" value="VAB18032_08045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08045"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_1_2_11"/>
    <dbReference type="OMA" id="CGVDPVG"/>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="125" mass="14111" checksum="F235FBFD01269AD9" modified="2011-06-28" version="1">MTGYLGSYATLGLLLLVSVLFLVVAFSANRVLRPARPADPPGKRASYECGVDPVGGDWAQMQIRYYVYAYLYVLFAVEAVFLFPWALIFDRPDFGLVTVVEMAIFVAVLALGLLYAWRRRILHWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1P8</accession>
    <name>F4F1P8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735124.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27001"/>
    <dbReference type="EnsemblBacteria" id="AEB46473">
        <property type="protein sequence ID" value="AEB46473"/>
        <property type="gene ID" value="VAB18032_27001"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27001"/>
    <dbReference type="eggNOG" id="ENOG5032HFW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1516220_0_0_11"/>
    <dbReference type="OMA" id="DWCISGE"/>
    <dbReference type="OrthoDB" id="1874915at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312605" evidence="1">
        <location>
            <begin position="29"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="159" mass="16733" checksum="3D9CFDFD8D524C9A" modified="2011-06-28" version="1">MRVYQRSAALVVLTTVSLTLVGCGLIGGDKEPAEQPGRAPADEALAKSRERVQAYLDAMTAKDVAAGRSQLCTVLHESFDAAATGPNGDFADHFTVTQTEIVDIRPGPVGQEVSTVVTVTVGKREASRSLLFTVTRDGLDWCISGERPGGHSPSPTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1W3</accession>
    <name>F4F1W3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27326"/>
    <dbReference type="EnsemblBacteria" id="AEB46538">
        <property type="protein sequence ID" value="AEB46538"/>
        <property type="gene ID" value="VAB18032_27326"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27326"/>
    <dbReference type="HOGENOM" id="CLU_3391929_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="32" mass="2795" checksum="A7EF8FE4F1866DE5" modified="2011-06-28" version="1">MDPGPATGGAAGTPDVGGPETGDGIGGVATDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F205</accession>
    <name>F4F205_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uridine phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">deoD</name>
        <name evidence="6" type="ordered locus">VAB18032_03340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736384.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03340"/>
    <dbReference type="EnsemblBacteria" id="AEB47752">
        <property type="protein sequence ID" value="AEB47752"/>
        <property type="gene ID" value="VAB18032_03340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03340"/>
    <dbReference type="eggNOG" id="COG0813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_2_0_11"/>
    <dbReference type="OMA" id="PQCLLCG"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01627">
        <property type="entry name" value="Pur_nucleosid_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="235" mass="25507" checksum="28DD6EF68B2BFFD2" modified="2011-06-28" version="1">MSTHIGAKPGEIAERVLMPGDPLRAKWIAETYLEGANCYSTVRGMLGFTGRWNGVEVSVQGSGMGMPSASIYAHELVNEYGVKSLIRVGSCGALSEDLQLRDVIAAIGSSTDSNMNRVRFDGLIDYAPVADFGLLRTSVEVAERRGIAMRVGPILAADAFYTDRPDLYDRLADYGVLAVEMESAALYTIAARFKARSLTLLTVSDHIKTGEKTTSQEREQTFSQMVEIALDTIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2A7</accession>
    <name>F4F2A7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_08390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731467.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08390"/>
    <dbReference type="EnsemblBacteria" id="AEB42796">
        <property type="protein sequence ID" value="AEB42796"/>
        <property type="gene ID" value="VAB18032_08390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08390"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_11"/>
    <dbReference type="OMA" id="IWREAGW"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="104"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="334" mass="37041" checksum="19D91059B89160CC" modified="2011-06-28" version="1">MTVREVTAEAGSDQTRPGGAAPRRRRLPLRTRLRRDWQLLAMVAPGFVILLIFSYLPILGNVIAFQDYNPYVGSNPLDAFVQSNWIGFGQFQLLFADPAFWHAFRNTLAITAFQLVFFFPLPILLAIVLHSLLSSRLRGFIQTVVYLPHFFSWVLVVSFFVAMFGGAGLLAQTMREAGMEPWNVMTNPDTFIILVTAEAVWKDVGWGTIVFLAALSTIDQNLYEAAAADGAGRWRRLWHITLPGLRPVIVLLLILRLGDALSVGFEQFLLQRDAVGRQASEVLDTFVYHFSIATGNYGYGAAAGLFKAAVGLCLILAANKVAHMLGERGIYSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2H1</accession>
    <name>F4F2H1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_14655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
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            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2M7</accession>
    <name>F4F2M7_MICM1</name>
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            <fullName evidence="3">Hydroxyacylglutathione hydrolase</fullName>
        </submittedName>
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        <name type="synonym">Verrucosispora maris</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
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                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
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            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
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    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="188"/>
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            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="22072" checksum="AD4B6DFDCD60207B" modified="2011-06-28" version="1">MTARIDHAVTSGTFSLDGQTFDVDNNVWVVGDDTECVVIDAPHDVDAICKVVAGRRVTAIVATHAHDDHVRVAPQLSRATGAPVLLHPADRVLWDMVHPDEPPGGELHDGQRIQVGGSTLTVLHTPGHSPGACCLHDAAQEVVFTGDTLFAGGPGATGRSYSDFGTIIDSIRDRLLTLPPQTVVRPGHGDSSTIGAEAPQLPQWLARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2N9</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rtcB</name>
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    </gene>
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        <lineage>
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            <taxon>Micromonosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
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            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
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            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
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        <text evidence="4">Monomer.</text>
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        <text evidence="4">Belongs to the RtcB family.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:RNA ligase activity"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
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        <location>
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        </location>
        <ligand>
            <name>GMP</name>
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        </ligand>
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        <ligand>
            <name>Mn(2+)</name>
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        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <begin position="322"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>GMP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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        <location>
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            <end position="374"/>
        </location>
        <ligand>
            <name>GMP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
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            <position position="378"/>
        </location>
        <ligand>
            <name>GMP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="472" mass="49910" checksum="47A140F61EBB03EC" modified="2011-06-28" version="1">MELVEESPYRFRIDRRDPMRVPGVIFASRALLPDPVADRSLEQVANVATLPGIVGASYAMPDLHWGYGFPIGGVAATDVAVGGVVSPGGVGFDISCGVRLLAADLDRDELRPRLEAVMDALSAATPRGMGSGAVWQLTGRDELDAVLRGGSRYAVQRGFGIERDLLRCEDYGAVHDADPAQVSDRAIERGAHQVGSLGSGNHFLEVQAVDQVYDVPVAEAFGLRPDQVCVMIHCGSRGLGHQICTDHVRAMEQVMGSHGIQVPDRQLACAPVASAAGRAYLGAMAAAANYARANRQLLAHATSRIFERETGRRLDLVYDVSHNLAKIEEHAVDGAVRRLCVHRKGATRALPPGHPDLPEELRDVGQPVLIPGSMGTGSYVLTGVANSPAFASTCHGAGRVRSRKQAVAAGTGGDPRAELEARDIVVRGASRRGLAEEMPAAYKDVSAVVEAAEGAGLCRKVARLVPLGVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2R9</accession>
    <name>F4F2R9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733988.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21170"/>
    <dbReference type="EnsemblBacteria" id="AEB45334">
        <property type="protein sequence ID" value="AEB45334"/>
        <property type="gene ID" value="VAB18032_21170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21170"/>
    <dbReference type="HOGENOM" id="CLU_2703807_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="73" mass="8568" checksum="10871C40DA3B1901" modified="2011-06-28" version="1">MEFLLAFALTGLVATSGWIAWAGVRGWSRFRDRRHELRLARARSAAELRQAELRQAELANETYQDFVRRHPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2U7</accession>
    <name>F4F2U7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735208.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27426"/>
    <dbReference type="EnsemblBacteria" id="AEB46558">
        <property type="protein sequence ID" value="AEB46558"/>
        <property type="gene ID" value="VAB18032_27426"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27426"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016537_0_0_11"/>
    <dbReference type="OMA" id="YPLWLHF"/>
    <dbReference type="OrthoDB" id="796556at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="605" mass="65844" checksum="F31A3498D8541A5B" modified="2011-06-28" version="1">MPTSPSVASAPTSPVRVTRDRRADLIVTLVALALAVWVTSGLWRDPNGRAITVNSSDQALFEWLLAFGGHAVSHGDNPLYTYLINVPDGVNLAVNTSITVYAVVFAPLTYLIGPPATFLVILTLNLAATAVAWYWLLSRHLVRSPLAAAVGGLFIGFSPGMVSHANAHLNWTAGWLVPLLVWRLFALRRPGHWLRDGVILGVLVAISFSIAAEGLFFTALALGLFVAVWALHPANRAQARAVLPSFLRGLAVTAVVAGVLLAYPLWLHFAGPQRFHGTGFDPVIHSEDIAAYAAFPRRSLAGEAGLRTTLAPNPTEENSFFGWPLLVLTLCCFVLLWRRADPHRRATLWALGVLAVVFTVLSFGPVAKVDGRRTDLPMPFDLLGQLPVVNAALPARLALVVTPVIGVLLAYAIDQLRQRPPRRAAAVAWTLGFVAALLPLFPTPLLTIEREPIPRFITSGAWREYVSPGGTLTPAPLALDVYPDGQRWQAYALANRQGEFAIPSGFFLGPGGPDGRGRIGPVPRPFSALLDQAARTGLPPIVTEGTREEVRADLEHWRIETVVLPDEVHGAKWPVDEEALRRTLTMLLGEPERVEDVWLWRVRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Y6</accession>
    <name>F4F2Y6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27621"/>
    <dbReference type="EnsemblBacteria" id="AEB46597">
        <property type="protein sequence ID" value="AEB46597"/>
        <property type="gene ID" value="VAB18032_27621"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27621"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_1_2_11"/>
    <dbReference type="OMA" id="EVAYDIY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="30596" checksum="FAC4C046665EBA6C" modified="2011-06-28" version="1">MPTVADVVAELERRYPPSWAEEWDRVGLVLGEPDAQVRRVLCVVDVVPETVAEALAAGVDMIVAHHPLLLRGVSSVAPTTYKGRIIHQLIKADIALYVAHTNADVAAPGVSDALAGRLGLTDLRPLQPARPGTPAAGEGRGVGRIGRLPRPMSLAELTRHAATVLPVTAVGVRAAGAPDRIVRTLAVCGGSGDSFLADASAAGVDAYLTADLRHHPAGEHLATGGPALLDATHWATERPWLDDLAALLRGTSGVEALVSDLDTSPWTVHAAPPSTGRPAVAEPVADDKEPDREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F320</accession>
    <name>F4F320_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736431.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03585"/>
    <dbReference type="EnsemblBacteria" id="AEB47799">
        <property type="protein sequence ID" value="AEB47799"/>
        <property type="gene ID" value="VAB18032_03585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03585"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051827_1_0_11"/>
    <dbReference type="OMA" id="WNPFAPG"/>
    <dbReference type="OrthoDB" id="1105091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312642" evidence="2">
        <location>
            <begin position="33"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="347" mass="36595" checksum="11698A39EC39E35D" modified="2011-06-28" version="1">MIRTPLRALTRMLAVLAVVLAVVPISSTGAMAEPTSPAVTWAVQPADRNGPDGRRFIERTLDPGQVVTEHLAVRNFSDSAVVFSLKAADGYLTDKGRFNMLPSNEKSVDGGTWITVQETVTVEANGTKVVPFTITVPEDATPGDHPAGIAATVTSTGGTVAVESRVGFRVMLRASGTVTASVAISDLSTTYTPSWNPFSAGTLKVGYTAKNDGNVALTGTGKVSVDELFGLVKQEDPTQVTETLPGGVQVVDTQVDGVWGLGRLKTTVSVTPAVQGGDPTGAEIRPGTATVTTWIVPWPQLALLLLLGLLVLAYRVITQRRRRRLAQLLASAREEGRAEGRRTTPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3J9</accession>
    <name>F4F3J9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14975"/>
    <dbReference type="EnsemblBacteria" id="AEB44107">
        <property type="protein sequence ID" value="AEB44107"/>
        <property type="gene ID" value="VAB18032_14975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14975"/>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118048_0_0_11"/>
    <dbReference type="OMA" id="QGRWKAV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16837">
        <property type="entry name" value="BldD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038099">
        <property type="entry name" value="BldD-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037664">
        <property type="entry name" value="BldD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13784" checksum="5F9EE21BC300DE10" modified="2011-06-28" version="1">MVGSYERGDRAVTVSRLAELAEFYRVPVSELLPDGSGVRHEPTSKIVLDLERLYDEASEDLAYVARYARAIQQQRGDYNGRVLSIRADDLRALAIVYDASPSGLIERLTEHGVLVADPRAFFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3X1</accession>
    <name>F4F3X1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein dependent transport system inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_21610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21610"/>
    <dbReference type="EnsemblBacteria" id="AEB45422">
        <property type="protein sequence ID" value="AEB45422"/>
        <property type="gene ID" value="VAB18032_21610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21610"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="315" mass="33650" checksum="E3FB85F7B0587173" modified="2011-06-28" version="1">MLSRQAAGSPPAAPPGTTGRTPRPDDRRSRRLFLIGMLAPMTVLLLAFTVYPFVSVLVNSLRHNNLTRPDEQGFAGLTNFANTIGEPGLLRALLLTVGMVLVAVVAEFALGTLAAALLWRPLRGSRLYLALLVLPFGATPVAAYLSWRLMLNPDGGQINAALAAVGLPTPGWTSEPMLAVVALVVVDIWQWAPFITLVMLAGLKSLPDETFEAAALDGASALQRLVRIALPMLKPLVAFVVTIRAIDAVRTFDSIWIITGGGPGAATETLVVRIYRTAFNDLHIGEASALGLLLLVVLFIVGKRFAAPALQRLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F422</accession>
    <name>F4F422_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735318.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27976"/>
    <dbReference type="EnsemblBacteria" id="AEB46668">
        <property type="protein sequence ID" value="AEB46668"/>
        <property type="gene ID" value="VAB18032_27976"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27976"/>
    <dbReference type="eggNOG" id="ENOG50325N4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2452875_0_0_11"/>
    <dbReference type="OMA" id="TYGDADT"/>
    <dbReference type="OrthoDB" id="2027733at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="89" mass="9159" checksum="ED5CD9665FD75B91" modified="2011-06-28" version="1">MAAPTVTASLNATSYAPGAQMLLTVTYGDPDTKTLTVTVVVTDAQGNSSAPAKVTAVIDPLTVTVTDDSKRTWTRVSDNGTVAVYRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F458</accession>
    <name>F4F458_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cdp-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736503.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03945"/>
    <dbReference type="EnsemblBacteria" id="AEB47871">
        <property type="protein sequence ID" value="AEB47871"/>
        <property type="gene ID" value="VAB18032_03945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03945"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154461_0_0_11"/>
    <dbReference type="OMA" id="WMVNLVT"/>
    <dbReference type="OrthoDB" id="1380643at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="24150" checksum="3E9F593B8079ADA5" modified="2011-06-28" version="1">MSTLAEPSHPTVADFHRVNRGGGLFSESVSQWIGAVFALVAQRLGLRPTALTITNLVLGLATSATVVALAGPVAAGDVPAWLVGLLALVGWQVAYALDCADGQLARVTGQGSAAGARVDVLCDVAAQIALVAALSATAVAQRPSTPVWLVAAFAGSWMVNLVTSVMQSGPNAASMVTSTSLPVRLVKLVRDYGAVIFAAALVLAVAPALVFWVIAAFTIVNGGFLLASIAFSARASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F496</accession>
    <name>F4F496_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736541.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04135"/>
    <dbReference type="EnsemblBacteria" id="AEB47909">
        <property type="protein sequence ID" value="AEB47909"/>
        <property type="gene ID" value="VAB18032_04135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04135"/>
    <dbReference type="eggNOG" id="COG1834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057463_0_0_11"/>
    <dbReference type="OMA" id="KCCIAEL"/>
    <dbReference type="OrthoDB" id="592329at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="261" mass="28233" checksum="3237600D45F83C48" modified="2011-06-28" version="1">MCSPEYFAVEYAINPWMDVTRPVDPELAVKQWDRLRETLVGLGHEVHLLAPEPGLPDMVYAANGAFSVDGTVYGARFKHHQRTAEAAAHRAFYESQGWRFIAPNETNEGEGDFAYLPEAHGGLILAGYGFRTELAAHAEAQEALGRPVISLRLVDPRFYHLDVALASIDDGNIVYYPGAFSAAGQKVLAQLFPDAVLAEAEDVLAFGLNLVSDGANVVLNSEATRLAGRLKAAGYTPVPVELAELKKGGGSVKCCIAELRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4A0</accession>
    <name>F4F4A0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6457 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736545.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04155"/>
    <dbReference type="EnsemblBacteria" id="AEB47913">
        <property type="protein sequence ID" value="AEB47913"/>
        <property type="gene ID" value="VAB18032_04155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04155"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154370_3_0_11"/>
    <dbReference type="OMA" id="MARMRDW"/>
    <dbReference type="OrthoDB" id="2000847at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045598">
        <property type="entry name" value="DUF6457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20058">
        <property type="entry name" value="DUF6457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6457" evidence="1">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="82" mass="8445" checksum="26DBBEC14DF55136" modified="2011-06-28" version="1">MTVMDDWLTAACAELGVDPADVPVQPVLDLARDVAHQVLRPGAPVTAYLLGLAVGRGADPAVAAARLTELAGTWPVELGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4B8</accession>
    <name>F4F4B8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin biosynthesis MoaE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736563.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04245"/>
    <dbReference type="EnsemblBacteria" id="AEB47931">
        <property type="protein sequence ID" value="AEB47931"/>
        <property type="gene ID" value="VAB18032_04245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04245"/>
    <dbReference type="eggNOG" id="COG0314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089568_1_1_11"/>
    <dbReference type="OMA" id="WPLQRVS"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="14649" checksum="8AA07F8705D46F1D" modified="2011-06-28" version="1">MVILIGAVTEQPLDLAAHEAAVADHRAGAVVSFAGVVRDHDHGRAVASLEYEGHPSAERVLREVAAEIAADPEVYAVAVSHRIGPLAIGDAALVAAVSTAHRAAAFAACARLVDEVKARLPIWKRQVFTDGTEEWVNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4F4</accession>
    <name>F4F4F4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731583.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08970"/>
    <dbReference type="EnsemblBacteria" id="AEB42912">
        <property type="protein sequence ID" value="AEB42912"/>
        <property type="gene ID" value="VAB18032_08970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08970"/>
    <dbReference type="eggNOG" id="ENOG503133J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_983335_0_0_11"/>
    <dbReference type="OMA" id="VRTGWAM"/>
    <dbReference type="OrthoDB" id="1434834at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="30621" checksum="ABABF3AAD3DCACC1" modified="2011-06-28" version="1">MRTAAETEVRRPSAVRAMTVLLAVTAAATVVVEVLNWWYAPEQGFGLAVRTGWAMLRSIGFLLLIGHVRRGRTVARPLGLILAVTTVIAVGRLIVPRHGVPPLPGLLGFALLTALCVAVVWLLYRSPAIAGHLVRHRPRLVIERSGIFWRETPPRRPEANAWLLTSRVAAFTYSPLMLVPALVAVAEILDGRPFALPAVLFWLAAGIATSYLVLFCTAFLMRGKRWAGILLVVITVIVLAVDLPLCWWLLGVDGLIRDGTPLVAAAILALYGVRRASTAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4F5</accession>
    <name>F4F4F5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731584.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08975"/>
    <dbReference type="EnsemblBacteria" id="AEB42913">
        <property type="protein sequence ID" value="AEB42913"/>
        <property type="gene ID" value="VAB18032_08975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08975"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_2_0_11"/>
    <dbReference type="OMA" id="TKGQPDP"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="28771" checksum="70F402B76348ADD7" modified="2011-06-28" version="1">MTLRKLLYSVYERRLTAKLAGRPVPRHVGVMCDGNRRWAREMGFVDPNDGHRMGAERIKELLRWCDAAGVGHVTLWLLSTDNLSRPAAELDPLLQIIEDLTTELAEAGNPWRLRMVGALDVLPAHHAAALKAAEERTRDRSGGAQVNIAVGYGGRREIADAVRSLLLEHAANGGTLEELAGSLDVDDISEHLYTRGLPDPDLIIRTSGEQRLSGFMLWQSAHSEFYFCELNWPDFRRVDFLRALRSYATRQRRFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4H5</accession>
    <name>F4F4H5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ispH</name>
        <name evidence="6" type="ordered locus">VAB18032_09075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09075"/>
    <dbReference type="EnsemblBacteria" id="AEB42933">
        <property type="protein sequence ID" value="AEB42933"/>
        <property type="gene ID" value="VAB18032_09075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09075"/>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027486_1_0_11"/>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="317" mass="34555" checksum="43675BDCC51ED9C7" modified="2011-06-28" version="1">MLLAKPRGYCAGVDRAVQTVEEALKLYGAPIYVRKQIVHNKHVVRTLEAKGAIFVEENEEVPEGATVIFSAHGVAPEVYEQAKERSLKAIDATCPLVTKVHQEAKRFAAEDYDILLIGHEGHEEVIGTAGEAPEHIQLVDGPEDADRITVRDPNKVVWLSQTTLSVDETMETVARLKKRLPMLQSPPSDDICYATSNRQHVVKEIAAECDVVIVVGSRNSSNSVRLVEVALDAGARAGHLVDFAHEIDDAWLVGAQTVGLTSGASVPDELVQEVLTHLAERGYTDVEEVVTANERLTFSLPQELKRDMKAAAAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Z9</accession>
    <name>F4F4Z9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21940"/>
    <dbReference type="EnsemblBacteria" id="AEB45488">
        <property type="protein sequence ID" value="AEB45488"/>
        <property type="gene ID" value="VAB18032_21940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21940"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093776_0_1_11"/>
    <dbReference type="OMA" id="IEWERGR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="188" mass="19880" checksum="2B823A052D669B9A" modified="2011-06-28" version="1">MARIATEVFAPALLAAVMPIVVGTASAPSIREGLPWALTGALFCAVIPNSLIWWGVRRGRLTDHHIRVREQRRTPLVYGLLSVIAGIALMVSFDAPRRLLAMVVVMLAIGVAVTVVNLFWKLSIHAAVAAGSAAVLVIEFGPTLLVSVPVVALVGWSRVRLGEHTTGQVLAGTIVGLLVAVPTFGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F519</accession>
    <name>F4F519_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28151"/>
    <dbReference type="EnsemblBacteria" id="AEB46701">
        <property type="protein sequence ID" value="AEB46701"/>
        <property type="gene ID" value="VAB18032_28151"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28151"/>
    <dbReference type="eggNOG" id="COG0232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028163_0_1_11"/>
    <dbReference type="OMA" id="AYDEDAH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="399" mass="43075" checksum="8B0AA646CA19C51C" modified="2011-06-28" version="1">MTEPVKDAGGGRSPYERDRARVLHSAAFRRLAAKTQVHTAGTDDFLRTRLTHSLEVAQIAREMGARLGCDPDVVDTAGLAHDLGHPPFGHNGEAALDTVAAACGGFEGNAQTLRVLTRLEAKVYDADGTSVGLNLTRACLDAVSKYPWPRRPGRRKFGVYADDRPVFDWLRQGAPPGERRCLEAQVMDWADDVAYSVHDVEDGIHGGYLTLGLLLADADERAALCADVAATYSGEPPDYLGQVLMEVLADPLLAPLAGYDGSHRAQAALKATTSVLTGRFVADAVAATTARFGPGPHRRYAADLVVPRSLRARCALLKGIALRYVMRRPGAQGRYQRQQEIITDLVRVLTDQAPEALDPVFAPLWHAAPDDAGRLRVVVDQVASLTDPAALAWHARLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5C4</accession>
    <name>F4F5C4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">VAB18032_04450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736603.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04450"/>
    <dbReference type="EnsemblBacteria" id="AEB47972">
        <property type="protein sequence ID" value="AEB47972"/>
        <property type="gene ID" value="VAB18032_04450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04450"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036138_3_1_11"/>
    <dbReference type="OMA" id="NFIYYPV"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="267"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB47972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="325" mass="35894" checksum="9B8A6C57C196FF67" modified="2011-06-28" version="1">MFSLDWIYYAISWILLAWHSAWDAIGVPETAVLGTNWSWILAIIFLVVTVRVILFPIFVKQIKSQRAMQALQPQVKALQEKHKGDRETLQKEMMELYRKEKANPLMGCLPMFLQIPVFLGLFHVLRRLNPDPAKANKDIYGWTVEQFNSASDATLFTAPIASKFGSTAAELAQLGANGTTVKVMAGILVLVMMGTTYLTSRQMILKTGWAEDPQQRMIQRLMLYGIPLSLLISGAIFPIGVIIYWVTNNLFTLGQQQWVLRKFPPPVTATSKPGTGAQPAKTSGLFGRSKPAPAPTKPATPKVAGPKPGAKPANPKKGRPAKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5J4</accession>
    <name>F4F5J4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_09540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09540"/>
    <dbReference type="EnsemblBacteria" id="AEB43026">
        <property type="protein sequence ID" value="AEB43026"/>
        <property type="gene ID" value="VAB18032_09540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09540"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="ARFMGDH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="385" mass="41752" checksum="D43FD2A9E7D1EEBC" modified="2011-06-28" version="1">MTMARETPAGDLRLANLTKTFGAFTAVDDLSLTIGQGSFFALLGASGCGKTTTLRMIAGLEEPTSGQVLLGDRDIAGLRPYKRPVNTVFQSYALFPHLDIFENVAFGLRRRGIRSVDSQVREMLSLVQLDGYERRRPTQLSGGQQQRVALARALINHPQVLLLDEPLGALDLKLRRQMQIELKRIQTEVGITFVHVTHDQEEAMTMADTVAVMNAGRIEQLGAPADIYEFPATAFVANFLGQSNLIAGEVSGSNGDDTLVTARGARFSVPSARARTDQGPVYLGVRPEKLHLAGAAVQVPAGSQHLEGTISDASYVGVSTQYLLRTSWGTELSVFVANSGTQQRFAVGERAVAYWDPRHAFLLGRRADEDDRTTPVLDQPVGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5L5</accession>
    <name>F4F5L5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mscs mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44228">
        <property type="protein sequence ID" value="AEB44228"/>
        <property type="gene ID" value="VAB18032_15580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15580"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2830070_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="66" mass="7934" checksum="A1BD774D97BB0819" modified="2011-06-28" version="1">MIRPCDDRMLNLLTTWFTEHSLQNWIRHETRVIGETRLHVDQTADPDDLRAEARRLVKASPLWDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5P4</accession>
    <name>F4F5P4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44257">
        <property type="protein sequence ID" value="AEB44257"/>
        <property type="gene ID" value="VAB18032_15725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15725"/>
    <dbReference type="HOGENOM" id="CLU_703873_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="392" mass="42641" checksum="5B795A0A3E0D4011" modified="2011-06-28" version="1">MADRVAARLVTVAGARLTKRGTFDVQVCDRPPYRVSQFMDAYVKRMADNGPSRSAGDNAVLQDLVRSLKGGSEIPGDLAAIDVALKDDRGYGLVDLLAAQEFLIQVSGADDRSVTGFLFSSWENLEDCIRANMDRLLPAAHPDGVLEACQHLIWTQALLQNSPLQMLEYRESVGRLYSRPVLELGDGSLFVPRNVPGLARVVLLQRILEGTWPEQLQARDASLSRALEQRRQLVRPIAGFEADLQRTLASTGLPFVAGVLQSVLGRPSDLLGVPVRAEIDAVVVVVHSLTIWVLEAKDLAIPFAPGRIRSEVNKYQRAGGHVDKLLAKVADVAADPAEVAARLGVADVAGAFAVRGLFVTREPTPAAFTDDRTHDFVTLDRLPDFLWNQPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F622</accession>
    <name>F4F622_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22405"/>
    <dbReference type="EnsemblBacteria" id="AEB45581">
        <property type="protein sequence ID" value="AEB45581"/>
        <property type="gene ID" value="VAB18032_22405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22405"/>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_0_0_11"/>
    <dbReference type="OMA" id="SHSARIW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="266" mass="28977" checksum="FF92A54763468036" modified="2011-06-28" version="1">MTDASPLSAAIRSDIPHSARLWNYLLGGKDNFAADREAAQQVLAYMPELVQSARFNREFLGRAVRHLVAEAGVRQFLDIGTGLPTANNTHEVAQSVAPETRVVYVDNDPMVLVHARALLTSDPQGATDYIDADVRQPDHILTEARRTLDFTRPVAVMLLGILNFVVDDAEATRIVRRLVEALPVGGYLVISHPTREVNPEAVDRAMDSWRAGGGAAMAVRTPAEIAAFVDGLEILEPGLVTCSQWRPDGNDTTPVSEYAVVARKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F640</accession>
    <name>F4F640_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="5" type="ordered locus">VAB18032_28606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 4">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735441.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28606"/>
    <dbReference type="MEROPS" id="S14.009"/>
    <dbReference type="EnsemblBacteria" id="AEB46792">
        <property type="protein sequence ID" value="AEB46792"/>
        <property type="gene ID" value="VAB18032_28606"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28606"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_11"/>
    <dbReference type="OMA" id="GFKRQDP"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="24296" checksum="C547AA05A77BFFD3" modified="2011-06-28" version="1">MTDLSLPPQFAAVHNRYVLPSFVERTSYGVKESNPYNKLFEDRIIFLGVQVDDASANDVMAQLLTLEGTDPDRDIIMYINSPGGSFTAMTAIYDTMQYVRPDIQTVCLGQAASAAAVLLAAGTPGKRMALPNSRIIIHQPATEGGYGQGSDIEIQAREILRMRTQLEEMLSRHCNRPIEKVRKDIDRDKIMTAEESREYGLVDTILSSRKKGLLAANAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F674</accession>
    <name>F4F674_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name evidence="3" type="ordered locus">VAB18032_28776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735475.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28776"/>
    <dbReference type="EnsemblBacteria" id="AEB46826">
        <property type="protein sequence ID" value="AEB46826"/>
        <property type="gene ID" value="VAB18032_28776"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28776"/>
    <dbReference type="eggNOG" id="COG3483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063240_0_0_11"/>
    <dbReference type="OMA" id="WRWRNDH"/>
    <dbReference type="OrthoDB" id="1660023at2"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="299" mass="33691" checksum="20BEB9BAB74B77F1" modified="2011-06-28" version="1">MEQTELRPGTRTAVRPVTGKQRAARAARNGGEPTLEFAERVPYDAYVQASTLHTLQQPLSDDPGEMSFLMVSQIMELYFGLTCHELRETSRLLRTDRVWEALAPLRRAALHLEALNAAWHGLRWMTPADFNRFRNLLGEGSGFQSAMYRHLEFLLGLRDAALIRPFRRQTEVYADLNATLATPSVWDEVVALLARHGHDIPADLLDRDIRDEHQPHAAVEAAWVRIYGDSGPDNHLRMLGEALTEVAEQFGDWRHHHVKAVQRTMGAKVGSGGSAGLAWLQRSMARVVFPELWSARTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F678</accession>
    <name>F4F678_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hnh endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28796"/>
    <dbReference type="EnsemblBacteria" id="AEB46830">
        <property type="protein sequence ID" value="AEB46830"/>
        <property type="gene ID" value="VAB18032_28796"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28796"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099824_2_0_11"/>
    <dbReference type="OMA" id="WRIIGTG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="170" mass="18570" checksum="FC6E148C57D726E7" modified="2011-06-28" version="1">MGSGALVLNATYEPLCVVSVRRAAILVLSAKAVCVADGEGVLHSARSALPVPSVVRLTRFVRVPYRTHVGLSRRAIFARDGWRCAYCRGPAETIDHVFPRSRGGPHAWENVVAACARCNHTKGDKTPAELGWRLHSLPAAPKGIAWRVLGHRAPDPRWADWLDLREPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F684</accession>
    <name>F4F684_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735485.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28826"/>
    <dbReference type="EnsemblBacteria" id="AEB46836">
        <property type="protein sequence ID" value="AEB46836"/>
        <property type="gene ID" value="VAB18032_28826"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28826"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_2_0_11"/>
    <dbReference type="OMA" id="CPLRWSD"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="148" mass="16731" checksum="007528D2BD94355B" modified="2011-06-28" version="1">MADRFVYHCTLRWSDLDAYGHVNNARFLTLYEEARVALMFVGARAQGIDSFADGVVIRRHEVDYLRPVDYALGRATADAAPTVRIEMWVGRIRAASFTVSYEMYDGELLVSRAQSVLVPFDLARQVPRRLTDREHSFLLGYAPDGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F689</accession>
    <name>F4F689_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uroporphyrin-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">VAB18032_28851</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735490.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28851"/>
    <dbReference type="EnsemblBacteria" id="AEB46841">
        <property type="protein sequence ID" value="AEB46841"/>
        <property type="gene ID" value="VAB18032_28851"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28851"/>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_1_0_11"/>
    <dbReference type="OMA" id="GRFMAQE"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012409">
        <property type="entry name" value="Sirohaem_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036426">
        <property type="entry name" value="Sirohaem_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="14">
        <location>
            <begin position="175"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036426-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB46841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="413" mass="42627" checksum="1C0FDA8B0792DAB6" modified="2011-06-28" version="1">MTSPYPLGLRLAGRRVVVVGGGAVATRRVPALLDAGADVLLVAPEISPALQAHADADRLRWIPRRFHPDDLDDAWLVHVAIDDPDAAAAVSAAAAQRRIFCVRADDREAATAWTPAVTRHGPVTVAVLGGGDPRRAMTVRDAIRTLLHERKGTLLTPAVEQGTPVNTPTGAPGRVALVGAGPGDPELVTVRGWRLLTEADVVVADRLVPGLLLDELRTGVELVDASKIPYGPARTQEEINRILVDRALAGAFVVRLKGGDPYVFGRGGEELLACAAAGVPVTVVPGVTSSIAAPAAAGIPVTHRAVAHEFTVVSGHVAPDSAASLVRWDALAALRGTLVILMGLKNLPAITATLLRHGRPADTPAAVVQEATTGAQRTLRSTLGEVAGDVAAAGVRPPAVVVVGDVVGVLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6C3</accession>
    <name>F4F6C3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731740.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09755"/>
    <dbReference type="EnsemblBacteria" id="AEB43069">
        <property type="protein sequence ID" value="AEB43069"/>
        <property type="gene ID" value="VAB18032_09755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09755"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688510_0_0_11"/>
    <dbReference type="OMA" id="WQAEIGN"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="214"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="43773" checksum="70AE2DFE3937A737" modified="2011-06-28" version="1">MEPVEITEAGLTLRPWRPTDADDLHRAGQDPEIQRWIDFPRPYRPQDAQRFIAGRTRQWAEGTAAAFAVCDAATGRLLGAADLQRIDRSRQLSEIGYWTAPWARGQGVAVRAVRALARWSFAELDLRRLLWTSRAGNHAARLVALRSGFRIEGRLRAADPAPGSYEWVGSLLPGEVPAPGEVGPAGPGSLEARRAAVFGRAQPTLFASTSRRELRLRPLEDRDLDALVITCQDPETLRWTTVPEAYDRSAAVSFLAHCEDCWAGGTATCFVIADEQDRYAGSIDLRLSSGDPLLATVGFMTAPHARGRGYQTAALAALTTWGFATLGLARIEWWAKVGNVASRRVAEKVGFAMEGTARAALNHRGTRADAWVGALLAEDLVPLSSAARTSAGTSNRPAAGQVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6G3</accession>
    <name>F4F6G3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731780.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43109">
        <property type="protein sequence ID" value="AEB43109"/>
        <property type="gene ID" value="VAB18032_09955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09955"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_6_11"/>
    <dbReference type="OMA" id="SQHPGCG"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="147" mass="15867" checksum="FD0D4F201B0B1B12" modified="2011-06-28" version="1">MTEETLAELGAALGDLHRVLRRTASQRTGRAALPDAQVEVLRLVQRQPGISVREAAERLGTAPNTVSTLVGELTSAGLLSRERDPGDRRTVRLELTDAARDRTAAYGQHRSELLAAALAQLEAADRERLLAATPALSRLADQVALQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6H4</accession>
    <name>F4F6H4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731791.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10010"/>
    <dbReference type="EnsemblBacteria" id="AEB43120">
        <property type="protein sequence ID" value="AEB43120"/>
        <property type="gene ID" value="VAB18032_10010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10010"/>
    <dbReference type="eggNOG" id="COG0510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077925_1_0_11"/>
    <dbReference type="OMA" id="ARSWARY"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="29832" checksum="A7FEBB83D97D549C" modified="2011-06-28" version="1">MPRRQHWHDLPAGVRRGVERHTGKVSHAESLPDGATCEFAVTLHSSAGRVFCKGGPADGPGAWLYRKEARINPWLPDAAPRLRWTVERDGWLLLGFEYASGLYPSLEPGSPDLDAVADLLAALARELTPCPPVDVQPFTERWRGLVNPELVDGDTLLHTDMTPRNFLFGDRLRLVDWSAPCRGAAWIDTAFMLVRLIRAGHGPAAAERWAARIPAFADADAEAVTAFTDALVRLWDRMQRTAPASHRGPLLDAARQWHAHRLSRRPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6R5</accession>
    <name>F4F6R5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734242.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22450"/>
    <dbReference type="EnsemblBacteria" id="AEB45590">
        <property type="protein sequence ID" value="AEB45590"/>
        <property type="gene ID" value="VAB18032_22450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22450"/>
    <dbReference type="HOGENOM" id="CLU_160040_1_2_11"/>
    <dbReference type="OMA" id="RSIRRWH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="89" mass="8805" checksum="A809791A50DC1D68" modified="2011-06-28" version="1">MTIPGIAAAVAVGLTVGALGRLVVPGRPGVPLWLTMTIGAAAALLGAISAWLVGARELNLLALIVQAGLATIGVVIVLATASKEHSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6T9</accession>
    <name>F4F6T9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734266.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22570"/>
    <dbReference type="EnsemblBacteria" id="AEB45614">
        <property type="protein sequence ID" value="AEB45614"/>
        <property type="gene ID" value="VAB18032_22570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22570"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="PEVMFFD"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="243" mass="26270" checksum="0AB341C43C4AD106" modified="2011-06-28" version="1">MSDSVSLSLRDVHLAFGRHQVLRGVDLDVARGATACVIGPSGSGKSTLLRTVNRLLEPDRGDVLLDGRSVLRDDPDALRQRVGMVFQQFNLFPHMSVLRNITLALRRIRKLGEDEAAAVAREHLDRVGLAAKADARPAHLSGGQQQRVAIARALAMQPQVMLFDEATSALDPELVKGVLALMADLSAQGMTMVVVTHEMGFAREVADTVAFMDAGVVLEAGPPAAIFEAAQHPRLRRFLSQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6U7</accession>
    <name>F4F6U7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding region atpase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22610"/>
    <dbReference type="EnsemblBacteria" id="AEB45622">
        <property type="protein sequence ID" value="AEB45622"/>
        <property type="gene ID" value="VAB18032_22610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22610"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133205_0_0_11"/>
    <dbReference type="OMA" id="THRSDGM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="34"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="168" mass="17138" checksum="EF0B7254AAB29D57" modified="2011-06-28" version="1">MSNLDRPDASGPDGASSGGDEVDSLLSLSFTGQTVTALRHLLAARIAAAGLRGDAAEDLVLAVHELVTNAVLHGGGRGRLELLRYPDRLVCEVSDHGPGGLGLTVQRPATDTPGGRGLWLAHQLTGALTLTHRSDGMTATVTAPLISGPTDPTRAEGTATGDGGLPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6V0</accession>
    <name>F4F6V0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amylo-alpha-16-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734277.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22625"/>
    <dbReference type="EnsemblBacteria" id="AEB45625">
        <property type="protein sequence ID" value="AEB45625"/>
        <property type="gene ID" value="VAB18032_22625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22625"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019216_1_0_11"/>
    <dbReference type="OMA" id="WPWDNAI"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="1">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="680" mass="77057" checksum="C211181F71276AD3" modified="2011-06-28" version="1">MKRMVRILDGNIFALSEDNGDMTFDPPSPSGFFVFDTRFLSTWRLTLDGEQLHPLAIHEPSYYEIRLFLVPGNPTHYVDAKVSIIRDRWISDSSFTERLTVLNHTCEPAEYVLRIDIDSDFAPIYNVVWPRATRLRGYREVSEDRLRLGYRRERFHRATEVSTTEPAAVDNQGMTYRIQVDRQGRWSTTLTVRSLVLRPDGADVREQLGHTHGQVGTQLRHDLSRWLADAPRLHCDWQPLTTTYRRGLTDLAGLRFAPLAMPHETMLTAGLPWSATIVGRDAILTCYQTLPFVPRTAATTLRLLALDQGTVLDDFRDEEPGKILNEFRYGELAAFEERPQSPYFGGADVTPLFVVLLDEYERWTGDGQLVRDLEEAARAALHWIDEYGDIRGDGYLWYRRRNENSGAMNHCWKDSPEAICYRDGRLPGLPRATCELQGYAYDARRRGARLAREFWGDPAYADRLERQAEELKQRFNRDFWIEQGEYFALALGPDGDHVDALASNMGHLLWSGIVDESRAPAVARHLLGPQMFSGWGVRTLGTGQARYNPLGYHLGTVWPFDNALIAAGLRRYGFVAEAGIIAEGVIDAAQHFGGRMPESFAGYERALTRYPVPYPAANSPQASATGSTFLLLRTLLGLEPYGEHLVVHPAIPQRFGRIELLDIPGRWGRMDAIGNARITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6X4</accession>
    <name>F4F6X4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="7" type="ordered locus">VAB18032_22745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734301.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22745"/>
    <dbReference type="EnsemblBacteria" id="AEB45649">
        <property type="protein sequence ID" value="AEB45649"/>
        <property type="gene ID" value="VAB18032_22745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22745"/>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_6_0_11"/>
    <dbReference type="OMA" id="EMSFLDH"/>
    <dbReference type="OrthoDB" id="1848013at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="316" mass="34777" checksum="91AD502BDDAACA5D" modified="2011-06-28" version="1">MAFALRKRGPSQFERAADGSMTLVEHFRELRTRLFRASLAIVVGLIVGYLLAQPAFDLLAQPYCRLPGMTVDGECQQFLMLAPADGFILKLKLALWIGLIVGAPVWLFQLWAFIAPGLHRHERKWAYVFVTIAAPLFAAGAVLAYFVVDKGLAFLMEAGVTGTDQQLEVTRYISFVTTMILLFGVAFEFPLTLLMLNFTGVVSAKRLLSWWRVVVFICFAFAAVATPDPGPFGMTLLALCLSLLYFIAVGVAFLNDRRKGRGKEVYAGIGDDEASPLEVDREQVAAGQPVEAVSPIEAPEPVAAPKPIERRYDDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F744</accession>
    <name>F4F744_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735557.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29186"/>
    <dbReference type="EnsemblBacteria" id="AEB46908">
        <property type="protein sequence ID" value="AEB46908"/>
        <property type="gene ID" value="VAB18032_29186"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29186"/>
    <dbReference type="eggNOG" id="ENOG5033485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122754_0_0_11"/>
    <dbReference type="OMA" id="AFVVYWW"/>
    <dbReference type="OrthoDB" id="1918339at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="17332" checksum="074746F22D1D0590" modified="2011-06-28" version="1">MSESSAGPGTLGAMKRLWTPAWIARHVAMVVLVTAFLALGWWQVSRAAAGNAISWGYAVEWPIFAGFVVFVWWREVRHALRGAEAGPSAAVGEAPDAGDPTVVERAEAVEAAGVRPRPGIGRPVRVTRTVGGHGEEDAELAAYNRYLSWLNANPGAKPGDYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7N5</accession>
    <name>F4F7N5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734324.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22860"/>
    <dbReference type="EnsemblBacteria" id="AEB45672">
        <property type="protein sequence ID" value="AEB45672"/>
        <property type="gene ID" value="VAB18032_22860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22860"/>
    <dbReference type="eggNOG" id="ENOG5032S40">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122808_0_0_11"/>
    <dbReference type="OMA" id="VDSIDVY"/>
    <dbReference type="OrthoDB" id="1478484at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="20411" checksum="391CCF08630E4B15" modified="2011-06-28" version="1">MSRPGFGGGDLPAVFPDWSPYTDLESAARAYLRDPDVALEALGGVLRGASVLGFTLERFVNEVNGVWQEVVVCDGSRLVLWHGEDVPPGEGPPGSMTSSLRVVPVSSVTEVGCRRRLFRHDNGEIRVDSIDVYLLLTSLDETPPSEETAGGPRHDALRFGKTLDDGGAGQIARLEEFARLVASVVGRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Z5</accession>
    <name>F4F7Z5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ordered locus">VAB18032_29496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735618.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29496"/>
    <dbReference type="EnsemblBacteria" id="AEB46970">
        <property type="protein sequence ID" value="AEB46970"/>
        <property type="gene ID" value="VAB18032_29496"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29496"/>
    <dbReference type="eggNOG" id="COG1637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069350_0_0_11"/>
    <dbReference type="OMA" id="RCSVDYA"/>
    <dbReference type="OrthoDB" id="1002946at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="219" mass="24304" checksum="595CC28E5BB4C4CB" modified="2011-06-28" version="1">MRLVIAKCSVDYVGRLSAHLPPATRLLMVKADGSVSIHADDRAYKPLNWMSPPCRLEEAPGVWRVVNKAGEELRITLEEVFQDTSYELGVDPGLRKDGVEAHLQELLAANPETLGEGFTLIRREYMTAIGPVDLLCRDANGGTVAVEVKRRGEIDGVEQLTRYLELLNRDPLLAPVAGVFAAQEIKPQARVLATDRGIRCVAVNYDRLRGIERDELTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F809</accession>
    <name>F4F809_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735632.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29566"/>
    <dbReference type="EnsemblBacteria" id="AEB46984">
        <property type="protein sequence ID" value="AEB46984"/>
        <property type="gene ID" value="VAB18032_29566"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29566"/>
    <dbReference type="eggNOG" id="ENOG50331I5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122300_1_0_11"/>
    <dbReference type="OMA" id="FDCSLRW"/>
    <dbReference type="OrthoDB" id="2048416at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019675">
        <property type="entry name" value="DUF2550"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10739">
        <property type="entry name" value="DUF2550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="16845" checksum="B74523A56281D8DB" modified="2011-06-28" version="1">MEIVEGIGIGFAVIVGAILFLFIRRAVVTRSGGIIRLSVRTSTMLDGRGWSPGFGRFVGDELRWYRMVSFAVRPKRVLSRDGLSVERRRLPEGQERLAMPADWVILRCTSRHAPVEIAMARSTLTGFLSWLEAAPPGAVSPRLAPQQDWPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8F9</accession>
    <name>F4F8F9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733159.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44504">
        <property type="protein sequence ID" value="AEB44504"/>
        <property type="gene ID" value="VAB18032_17000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17000"/>
    <dbReference type="eggNOG" id="ENOG5033HI0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980227_0_0_11"/>
    <dbReference type="OMA" id="ECEVWAG"/>
    <dbReference type="OrthoDB" id="1818899at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="16680" checksum="A720F61D9DDB8074" modified="2011-06-28" version="1">MILAVRSGRGSEDAVSWVANVMLSVGLEDRLNAEAFSDWLDNRCRCREPGMGPGGCGSLRLITGVDHQWGGHKNPECQVFAGALNHADLTAVVEHFGSVAWRNPNAVQLFVMDQEEFFFRVWMIREGALRQYAPSSPNEEDDEFWPPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8S8</accession>
    <name>F4F8S8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lvivd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734473.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23615"/>
    <dbReference type="EnsemblBacteria" id="AEB45821">
        <property type="protein sequence ID" value="AEB45821"/>
        <property type="gene ID" value="VAB18032_23615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23615"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023239_0_0_11"/>
    <dbReference type="OMA" id="QTQPDYF"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309166" evidence="1">
        <location>
            <begin position="31"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="485" mass="52552" checksum="A294FF3D2EFEF481" modified="2011-06-28" version="1">MVIPTPARARWLRVASAAATGLLLASIAAAAPGNAQPVTQAAATSTSAAAPPLGVDEIAHSPNLRLIANLPKQSPFNTTNALGTDIAFQGRYAFVGNYDGFVIYDVSRPSQPKIVSQVLCPGAQNDISIYGDLLFLSTDSSRSDDSCNSVSQPASVKESWEGIKIFDVRNKKQPRYIKSVETACGSHTHTLVPAKNTKSVYLYVSSYSPQDAFPDCQPPHDSISIVKVPLKKPTDAAVVATPNLFPDGGYEGRTGASATTGCHDITAYPQKDLAAGACMGDGVLLDISKREAPRVLHRVRDTTNFAFWHSATFNNRGTKVVFTDELGGGGGATCNEAVGPERGANAIYDLTGRGDKRKLEFRSYYKIPRTNGDTENCVAHNGSLIPVLGKDIMVQAWYQGGISVWDFTDSRRPTEIGFWERGPLSDSQLVVGGSWSAYYYNGHIYSSDIQKGLDVLDLDDWRTWTAKLVQFRELNVQTQPSYLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8W9</accession>
    <name>F4F8W9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cuta1 divalent ion tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735697.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29891"/>
    <dbReference type="EnsemblBacteria" id="AEB47049">
        <property type="protein sequence ID" value="AEB47049"/>
        <property type="gene ID" value="VAB18032_29891"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29891"/>
    <dbReference type="eggNOG" id="COG1324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098807_3_1_11"/>
    <dbReference type="OMA" id="VYTTFPD"/>
    <dbReference type="OrthoDB" id="1801957at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="106" mass="11591" checksum="EE6787E0A6FA3323" modified="2011-06-28" version="1">MDQISVVTTVVDARSVADLLAAAAVAGRQAACAQVGGQVESTYWWRGGVETSTEWSVQFKTAPDRVSALVEQIRASHPYEVPEILVSQVYCGHPEYAAWVFEHTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8X6</accession>
    <name>F4F8X6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_29926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735704.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29926"/>
    <dbReference type="EnsemblBacteria" id="AEB47056">
        <property type="protein sequence ID" value="AEB47056"/>
        <property type="gene ID" value="VAB18032_29926"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29926"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="OMA" id="AKWIIDE"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="188"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="289"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="517" mass="55564" checksum="E6FB6F5A1024B1C1" modified="2011-06-28" version="1">MNALQQGKSRLRAVPLRVKLVAAVLALVAAALLVISSLTTFFLRSYLVGEVDSELATATRNIEQVAALEQPEAQIPTDYLLATTDPRTGAADWVFFDKRRFTTADLPRFPNDAAGFDHLAGEPRTARAQGSEVRWRVLYTQLPNGQRVAVAQHLIDVDRAVTRLVWIDVLVGGAVLILLASIGAAIVRTSLKPLVEIERTAAAIAGGDLSRRVPDPEHGQPCPTSELGRLSRALNAMLSQIEMAFTARAASESAARSAEAAARDAAEAARASEARARRSEERMRQFVADASHELRTPLTTIRGFAELYRQGAGRAPEQTADLLRRIEDEAARMGLLVEDLLLLARLDRERPLSLAPVELPVLAADSVAAARAMAPDRRIELDIAPGSGPLVVRGDDARLRQVIGNLMTNALRHTPPEASVTLRLRSEPGNLAVIEVADTGPGLTPDQAERVFERFYRADASRTRRVGGITGTGLGLAIVAALVTVHQGTVEVTDTPGGGATFRVRLPLAPDIDGEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Y0</accession>
    <name>F4F8Y0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735708.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29946"/>
    <dbReference type="EnsemblBacteria" id="AEB47060">
        <property type="protein sequence ID" value="AEB47060"/>
        <property type="gene ID" value="VAB18032_29946"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29946"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078243_0_0_11"/>
    <dbReference type="OMA" id="HPFPGCF"/>
    <dbReference type="OrthoDB" id="1818216at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="22625" checksum="C54126FE4FB8BAE7" modified="2011-06-28" version="1">MIIEARFNGPPGTGNGGWSAGVFATAYGGQRPVEVTLRRPPPLDTPLTLTDDQVHDPDGEVIAQLRPAEELDDVVPPVDPATARAASAAYPGLTDHPFPGCYVCGPQRLDGLRIFPGRLPDGRTAAPFQAPAQVSVATVWAALDCPGGWAVIEAGRPYVLGRIAAHVEALPRPGDECVVTGAVVEAMGRKALVRTSLYGPDGALLGHARATWIGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Z5</accession>
    <name>F4F8Z5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47075">
        <property type="protein sequence ID" value="AEB47075"/>
        <property type="gene ID" value="VAB18032_30021"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30021"/>
    <dbReference type="eggNOG" id="ENOG502ZSU9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159758_0_0_11"/>
    <dbReference type="OMA" id="LLPIGWF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="144" mass="15041" checksum="60CB15860145A493" modified="2011-06-28" version="1">MGRTVPRDGTGIVTRVTIDSNPTPVTLRWAVRLLRVEAVAVGLVAAWLIVADLTASTTDLTSALLVTAFAIGAAVALWALGSALVRHRAGARAPAIVLQLMLLPIGWFMIQGGLGWLGVPLIALGLGVTWLLVSPPTTRALGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F965</accession>
    <name>F4F965_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_04835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730767.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04835"/>
    <dbReference type="EnsemblBacteria" id="AEB42093">
        <property type="protein sequence ID" value="AEB42093"/>
        <property type="gene ID" value="VAB18032_04835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04835"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_2_11"/>
    <dbReference type="OMA" id="RKSSSWV"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="12"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="358"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="492"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB42093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="609" mass="64752" checksum="9A8ED1D42D3F5139" modified="2011-06-28" version="1">MTAQARLLGGRYQVGELLGYGGMAEVHRGRDLRLGRDVAIKMLRTDLARDATFQMRFRREAQNAASLNHPAIVAVYDTGEEQAPTGETLPFIVMEFVNGRTLKEVLGAEGRLQPRRALEICADICAALDFSHRHGIIHRDIKPGNVMLTQTGQVKVMDFGIARALASGATTMTQTSAVIGTAQYLSPEQARGEAVDARSDVYAAGCVLFELLCGHPPFVGDSPVSVAYQHVREAPPTPSDLNPEVNPAVDAIVLKALSKNPLNRYQSAGEMRADLLRAAAGRPVMATPVLREDETVPMSAASGSGYPSGGATQTRQIPARVGDPRQRRASSWLIAMFAALGVLAVIALVAALLLNDKTPEDVPVPTLSGMTQQEAFARLEADGFQPERGDDVFTSDCRKGRVTNQTPPAGERIAPNSTVTVQLCGGKPEATVPEGLVGSKVESATLRIEERKLRVKTVPKDSAEAAGLVLEVDPKEGEKVAENTVITLTVSKGNVVRVPNVENLTEADAKRELENAGFEWNVEIGPEVPADRAGRVTDQNPNAGSQRTKGTKVTIFVSVPEPEDDDPPTSAPPTGDPTTPPPDDDGGGGSGGGDGELLPIFPPFRLPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Q9</accession>
    <name>F4F9Q9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_23685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734487.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23685"/>
    <dbReference type="EnsemblBacteria" id="AEB45835">
        <property type="protein sequence ID" value="AEB45835"/>
        <property type="gene ID" value="VAB18032_23685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23685"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_3_11"/>
    <dbReference type="OMA" id="AHELMAC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="12614" checksum="9CD20D85D27F0896" modified="2011-06-28" version="1">MREREERFHVETTVSGDVVCVRVVGVIDIATVGAFRAALWAAPARSELRVDLSEVRLLSAAGVRALIAARLWVRAQGGQLVLVDPPPVVDRVLRATGLRRVIPIAEAAPDRILAAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9S5</accession>
    <name>F4F9S5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734503.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23765"/>
    <dbReference type="EnsemblBacteria" id="AEB45851">
        <property type="protein sequence ID" value="AEB45851"/>
        <property type="gene ID" value="VAB18032_23765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23765"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160408_0_0_11"/>
    <dbReference type="OrthoDB" id="1318387at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="26906" checksum="D49B584ECA63E15C" modified="2011-06-28" version="1">MTVTDGRSLTDEITAILVTNCGLDPDAAAREPAASLEELGMDSLALLELTAVVADRWRVRIPEQAARLSIPAVADLISRRADPPGHTENSIVIAAPLDLVWSVTNDVAGWPDLFTEYARAEILDTDGDTVRFRLTMHPDENGVAWSWVSERTPDRATRQVRARRVETGPFEYMRIHWTYTEEPDGVRMTWVQDFAMKPTAPVDNAGMTERINTNSQVQLAVIKERIERLAGVQPAAVATGGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9U2</accession>
    <name>F4F9U2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734520.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23850"/>
    <dbReference type="EnsemblBacteria" id="AEB45868">
        <property type="protein sequence ID" value="AEB45868"/>
        <property type="gene ID" value="VAB18032_23850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23850"/>
    <dbReference type="eggNOG" id="ENOG5033510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2157302_0_0_11"/>
    <dbReference type="OMA" id="KWIIAFF"/>
    <dbReference type="OrthoDB" id="1944880at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="111" mass="11613" checksum="427ABC7FB5EBC213" modified="2011-06-28" version="1">MNDLFTWAALGSLTGASAATLLTTNVIGGLIGPSADKARKWIALGIALALSYLTAAFATDAGPEKWIIAFFNGLVIFSAALGINQLPPGNRQATPIQLAQGNEPRFVRSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9X3</accession>
    <name>F4F9X3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734551.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24005"/>
    <dbReference type="EnsemblBacteria" id="AEB45899">
        <property type="protein sequence ID" value="AEB45899"/>
        <property type="gene ID" value="VAB18032_24005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24005"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OMA" id="SHMGYAS"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="35987" checksum="8A770A80348FAD8A" modified="2011-06-28" version="1">MALTTAPDPTRRGTGSVRPPATRRGTGRIRHGEGLAGYVFLSPWLIGLMGITALPMLLSLYLSFTNYDILTPWSEVEWVGLANYERMFTADPSWWHSVRVTLRFALIAVPLKLAAALGVALLLNRAWRGVGLFRGLFYLPSLLGGSVALAIVWVNMFNRDGAFNSFLALFGIEGKPWVNDPDWALETLMVLAIWQFGAPMVIFLAGLKQVPTELYEAASVDGAGRFRQFVSVTLPMLSPVIFFNLVLETINGFQGFTAAFVLSNGTGGPIDSTLMYTLNLYIAGFTDLEMGYASAMAWVFLIAIALITAVFFSTGRFWVHYSDGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA52</accession>
    <name>F4FA52_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="7" type="ordered locus">VAB18032_00395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735808.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00395"/>
    <dbReference type="EnsemblBacteria" id="AEB47163">
        <property type="protein sequence ID" value="AEB47163"/>
        <property type="gene ID" value="VAB18032_00395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00395"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_11"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="276"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="361" mass="38649" checksum="E9DC2EF3054DD97A" modified="2011-06-28" version="1">MSLTIGIVGLPNVGKSTLFNALTKNDVLAANYPFATIEPNVGVVGLPDERLHKLAEIFGSQKVIPAPVSFVDIAGLVRGASKGQGRGNAFLANIRDASAICQVVRAFSDPNVVHVDGKVSPADDIETINTELILADLQTLEKALPRLEKEAKLRKDRAAAVAAAKQAVEVLDGGTTLYAGATAAGIELEHLRELHLLTTKPFLYVFNVDEAELNNAEFLDELRALVAPADAVFMDAKIESELVDLPEEEARELLESIGQSEPGLNQLVRVGFRTLGLQTYLTAGPKEARAWTVPIGATAPEAAGVIHSDFQRGFIKAEVVSYHDLVEAGSMAAAKAAGKVRIEGKEYVMQDGDVVEFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB85</accession>
    <name>F4FB85_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_00730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47230">
        <property type="protein sequence ID" value="AEB47230"/>
        <property type="gene ID" value="VAB18032_00730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00730"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_1_1_11"/>
    <dbReference type="OMA" id="PYDYVEH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="15566" checksum="F8406382E5912F0F" modified="2011-06-28" version="1">MVLLTKHRITHRTHPYDVAADSPNYGALVAAAIGVPPGRVFKTLIAEVDGALTVAIVPVTGELDLKALAAAVGGKRATLAERGAAERATGYVRGGISPLGQRKRLPTVLDDSALEHDTVYVSAGRRGLQVELAPADLVALTDARTAPLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBF3</accession>
    <name>F4FBF3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05615"/>
    <dbReference type="EnsemblBacteria" id="AEB42249">
        <property type="protein sequence ID" value="AEB42249"/>
        <property type="gene ID" value="VAB18032_05615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05615"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408781_0_0_11"/>
    <dbReference type="OMA" id="TWSPKAD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="672" mass="70931" checksum="01B9AA0711C287D8" modified="2011-06-28" version="1">MVAPVSAAGTTLQSAQTVRPPAVSSDEYPMYPNSPNLDYTIGMAGTFRFLTYGTDTVAFAWRLGDDGPSGTVPAVDRLGYASITPVRAGLQTLYVRDMTADGAQLTETAYAFKVDDGPRLVDRGEDGATMVVGESRTVRLRPGRPDVVSYTYSLRDRVHKTYNTGTVAARPDGTADLTWTATHHEIDNLLVHSVSADGTVSASRYVSYSVDGAAPTVSRIPGVGWVEPTTFTARTRMANPVEYVVTVNSDENSRQILTPAADGSATFQLMPSVRGTHYINIFARDAAGVQTNSAIILWSVSNRPVVTSTDFPSNGVGRVWPGTFTFTAGMPGTTEFRYRINGAPSIAVPAGPDGTATVSWTPPTDGAHEVLLWSVTATGSTSDVTEHRFQLKRRLIALDHVTPGSVTTGEVHLLELTGYGMHKQDLIEVIPSDGKPVPAQVHHLTGGGAMMLVHADLTGVATGPATVRLTPHDELGSSVTWAGRFQIVAPPAPKATKLPAITGTVAVGSTVKASTGTWTPSATSYKYQWAANGTAIKGATSASLKITAALLGKKLTVTVTAIRTGHPNGKATSKATAAVAKGKAPKATKKPKISGTPKVGRKVKALVGTWSPKADSYKYEWRLNGKLIKGATGKTLKLTSKMRGKKLTVTVIARKAGHANGQATSAKVTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBL9</accession>
    <name>F4FBL9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732150.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11835"/>
    <dbReference type="EnsemblBacteria" id="AEB43481">
        <property type="protein sequence ID" value="AEB43481"/>
        <property type="gene ID" value="VAB18032_11835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11835"/>
    <dbReference type="eggNOG" id="COG3945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114921_2_0_11"/>
    <dbReference type="OMA" id="WYYNLTA"/>
    <dbReference type="OrthoDB" id="1693553at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="135" mass="14946" checksum="99A3BEB1970E413E" modified="2011-06-28" version="1">MSDWNDKIIAEFRANGGQVGGHFAGQPLLLLHTVGAKSGLPRVNPVMYQQVDGGYAVFASKAGAPTSPDWYHNLLAHPRVQAEIGTETVELVARVATDDERDRIWSAQKAAYPFFADYERKTTRRIPVVVLEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBR2</accession>
    <name>F4FBR2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_18050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733367.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18050"/>
    <dbReference type="EnsemblBacteria" id="AEB44712">
        <property type="protein sequence ID" value="AEB44712"/>
        <property type="gene ID" value="VAB18032_18050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18050"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_11"/>
    <dbReference type="OMA" id="WQIWGDA"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="2"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="121"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="460" mass="49602" checksum="8078AFA34C7C3126" modified="2011-06-28" version="1">MRFRSVLVANRGEIAVRIVRACRELGIRTVAVYSSADRDAVRDRLGDEQVHIGPAAARRSYLNAAAIIEAALQRGAEAVHPGYGFLSEDPDFAAVCAANGLTFVGPPPDVIGQFGDKAAARAAMADAGLPVLPGTGAAVEEAEARATADDLGYPVIIKAVVGGGGRGMEIVTAPEAFVAAYRRTRDSARLLFGDDRVCVERFLAAAHHVEVQILCDDHGNAVHLGLRDCSVQRRRQKLVEESPSPVVSAELAERIAAAALRGARAVGYRGAGTFEFLLDADRRDFYFIEANCRIQVEHPVTEMVTGVDLVREQLLIAAGHPLSIRQEEVRPQGVAVECRINAEDPDRNFTPSPGPLAEFVPPGGPFVRVDTHAYPGMTITPHYDPLIAKVICWGPDREVALNRMDRALAELRVAGPGVRTTTDFLRELIAHPLFRKGVHTTSLVDRVVAERQPQLTGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBW3</accession>
    <name>F4FBW3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44763">
        <property type="protein sequence ID" value="AEB44763"/>
        <property type="gene ID" value="VAB18032_18305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18305"/>
    <dbReference type="eggNOG" id="ENOG502Z859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1208741_0_0_11"/>
    <dbReference type="OMA" id="WGRPVEK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="21799" checksum="6A33CA6ECF26144C" modified="2011-06-28" version="1">MRLGSPVLSVERMQLRRLAMFAEWADESALERFLADDALGRRLAAGWHVRLQYLRRYGEVAALAGLPVQAGRWDPEEPMVAVTLARLKLLELPRFLKWGRPVERLVASHPGATFATAAMRPPHTFSTFTIWRSVREMTDMVHGRSAVPQADTHAVAMVEQHRRDFHHESAFMRFRPLSEHGTWEGRRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC17</accession>
    <name>F4FC17_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46015">
        <property type="protein sequence ID" value="AEB46015"/>
        <property type="gene ID" value="VAB18032_24585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24585"/>
    <dbReference type="eggNOG" id="ENOG50330BK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120348_0_0_11"/>
    <dbReference type="OMA" id="WHHRTER"/>
    <dbReference type="OrthoDB" id="2098345at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="187" mass="19425" checksum="25228D90B9C3B332" modified="2011-06-28" version="1">MFEMEVRGMTVDKLLRRWPAALGVLVAVGTVLGVEHGGQIAPVVAASGFVYLAAVAIGRPGAAWAAFGVTFVLVGLSLRAGFDAVLWICVAAAVLAVLGALRAGVRPVWSLPLQSAAMLVLGAAALLAVRADHLAAGVIVSVALFAHAAWDVWHHRTERVVTRSFAEFCGVLDVLVGVGLLVVTLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC30</accession>
    <name>F4FC30_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD linked oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734680.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24650"/>
    <dbReference type="EnsemblBacteria" id="AEB46028">
        <property type="protein sequence ID" value="AEB46028"/>
        <property type="gene ID" value="VAB18032_24650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24650"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_11"/>
    <dbReference type="OMA" id="PGAGVMI"/>
    <dbReference type="OrthoDB" id="330793at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="450" mass="48035" checksum="D07DB29E8E48895A" modified="2011-06-28" version="1">MTTAKSPRLDGCLLTAGDPGYDAARTVWNAMIDRRPRMIVRAASVSDVVIAVRLARELDLEIGVRCGGHNVAGFAVPANGLMVDLTLLNRVRVDPVRRRARVQGGALLGALDQATQPYGLATTAGNVSHTGVGGLTLGGGMGWLARQHGLACDNVVSYTIVTADGQVVTASRTEHPDLYWGLRGGGGNFGIVTEFEFRLHHTGTQTLVAEFDFRAEDAVAVLEGWRDLNAVAPRQATFTAEVSSTTSGPVATIGFVWVGDPAAGHRLLPAMRALGRPIAERVTMPSYLALQQRDDTVAGPAYRRYSRAHYLQQFPSTAIEAFLLRGASDLHAGTLLPGVGLQAHGGAIADVADTDAAFSHRSTLFEFGADARWTDPSEDDNRMVAARAAAATLDPYAGGVYVNSLAADEGRRGVRRAYPAAKLARLTTVKTRWDPQNVFHLNHNIRPGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC48</accession>
    <name>F4FC48_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-(ACP) synthase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734698.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24740"/>
    <dbReference type="EnsemblBacteria" id="AEB46046">
        <property type="protein sequence ID" value="AEB46046"/>
        <property type="gene ID" value="VAB18032_24740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24740"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075552_0_0_11"/>
    <dbReference type="OMA" id="TITHHAC"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="220"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="309" mass="33118" checksum="7A3C1B3CED38031A" modified="2011-06-28" version="1">MTSILAVASYLPPRSVAVADHLAELGIEVDAGLYQQYYGFGRIRRDPPGNLAEQLVAAGRRLDRLATDAPRVRYLVHAPTIAHTAPYPHTPLWQARAELGLHQALPFTLSQHACASALLAIDTCGRLLAADGDPDALALLLTGEKTFTGVAQFIADSAVLGEGVAAVLIGPGGDRDRVLSYATRTLGEFHEAPELSPRLQEEFQGRYTEVLAEVILAATRQAGLTTADITLVLPHNVNRISWWRVLTRAGLPKSRLFLDNQAELGHCFGADPFLGYQAALASGRLRPGDHYVLTAAGLGATLAATVVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD06</accession>
    <name>F4FD06_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18680"/>
    <dbReference type="EnsemblBacteria" id="AEB44838">
        <property type="protein sequence ID" value="AEB44838"/>
        <property type="gene ID" value="VAB18032_18680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18680"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056500_0_1_11"/>
    <dbReference type="OMA" id="WFGRERP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="138"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="29994" checksum="DB3AD067D70826D3" modified="2011-06-28" version="1">MLAFSMSLPATRVAVQQLDPWFVAFGRCVGAAVLAWGYLWITAAPWPSPRQWRRLSLVALGVVVGFPLFTSLALTSQTASHGAIVITVLPAMTAVFAVLRAGERPPPLFWIASTGGLLAVLAFLVANGAVVGAPAVADLFLLAAVVLAGLGYAEGGALARELGGARTICWALVLSLPVTVPIVAAVALAAPPHAGAGGWSAFGYLTVVSMFLGFFAWYAGLARGGIAQVGQLQLAQPVLTLAWSALLLGERVTPASIVAALVVLACVALIQRTRTTRQAIVVVPAAARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDC1</accession>
    <name>F4FDC1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_01240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735969.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01240"/>
    <dbReference type="EnsemblBacteria" id="AEB47332">
        <property type="protein sequence ID" value="AEB47332"/>
        <property type="gene ID" value="VAB18032_01240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01240"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_4_1_11"/>
    <dbReference type="OMA" id="AEIVFNG"/>
    <dbReference type="OrthoDB" id="1924578at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="13954" checksum="93F3E0A1A920DF42" modified="2011-06-28" version="1">MELPTQTFRVTRADLIRYAGASGDFNTIHWSDRLATKVGLPGVIAHGMFTMALVGRAVTTWAGAPDAVVDYGVRFTRPVVVPDDDFGTEIVVTAVVREVTEDGLTRLDITATCQGDKVLSMARATVRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDF0</accession>
    <name>F4FDF0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735997.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01385"/>
    <dbReference type="EnsemblBacteria" id="AEB47361">
        <property type="protein sequence ID" value="AEB47361"/>
        <property type="gene ID" value="VAB18032_01385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01385"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_6_0_11"/>
    <dbReference type="OMA" id="GLYTAWM"/>
    <dbReference type="OrthoDB" id="1249292at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="478" mass="48871" checksum="E0D0B9163A95B49D" modified="2011-06-28" version="1">MTAPPSGSGAPALPRKVHAGYALGSLATGAFGTVPGLLLLPYLTDTLGVAAGVAALLVLLPKAWDVLVNPVAGRISDRTRSRWGARRPYLLVGGLALAVLFGSIFAAPFGAGSAAGAYVAVAFLATATAFAFFQVPYVAMPAELTSDYAERTRMMTWRIAVLALAILVSGAVAPLVRDAAGGGLSGHRWMGLFVAALIALGAVGAFLGTRSAPQQVVTESEPSLRAQLAVAGRNRPFRALLLCFVVQSAGVATILAGVQYFADQILRDPKTGPTLLFLCFVGPALVVMPLWSRVGARLGKLAGLVIASLILAGGGLALVAAPLLPAAVIYLLVALIGVGYAGQQVFALAMLPDCIAYDTARTGRRQAGVFTGLWTAGETFGLALGPGIYGLVLALTGYVSSTTGTSAAQSDTARLGVLLGFTILPALLIALASLLLRPYNLTEALLTTLPTPTPLSADHGVVVGTKAANHHEEGTTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDH8</accession>
    <name>F4FDH8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trka-n domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736024.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01525"/>
    <dbReference type="EnsemblBacteria" id="AEB47389">
        <property type="protein sequence ID" value="AEB47389"/>
        <property type="gene ID" value="VAB18032_01525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01525"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_3_1_11"/>
    <dbReference type="OMA" id="PEYEAGC"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="223" mass="24095" checksum="C221A739FC3D1E13" modified="2011-06-28" version="1">MSASKPDTDGIAVIGLGRFGSRLAESLSALGHEVLAIDRDSRRVQKWSALLDQVAQADSTDGQALRQLGVADLNRVVVAIGASLESSVLTVLALVELGVPQIWARATSTQHSKILSAVGAQHVIFPEKETGERMAHLIASRMLDFMEFGDAFAIAKMHVPAPMAGHRVSEQQLLDRYGIRIIGVKRPAEQRYRYVSDSLLLGPDDIVIVEGTIDQVQAFASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDJ8</accession>
    <name>F4FDJ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, iclr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_06185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731034.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06185"/>
    <dbReference type="EnsemblBacteria" id="AEB42361">
        <property type="protein sequence ID" value="AEB42361"/>
        <property type="gene ID" value="VAB18032_06185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06185"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_5_2_11"/>
    <dbReference type="OMA" id="APRVDLW"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="28463" checksum="2C500EF80082EF35" modified="2011-06-28" version="1">MRDPLAEPSDLIRSVSRALRVLESVGRAPRGLTVKQIARRCELTVATTYHLVRTLAYEGYVIRREDGTYIVGLEVADRYRELVAAFRGSPAVGETLRRVALETGWSHYLGRFVGGQVAITAVAEGHRSPYLEDLVPGFDEGAHATALGKALLATLTAEQRHRYLREYGMRPFTSTTLSTPEAFEADLAAGERRGMQLELGQFRQGVACAAVLISPDKDMERRTVLACALPASEMMTSARVVRTKLLTAARAIADSLATDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDP5</accession>
    <name>F4FDP5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06420"/>
    <dbReference type="EnsemblBacteria" id="AEB42408">
        <property type="protein sequence ID" value="AEB42408"/>
        <property type="gene ID" value="VAB18032_06420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06420"/>
    <dbReference type="eggNOG" id="ENOG502ZPCI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1834322_0_0_11"/>
    <dbReference type="OMA" id="GEWRICE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313825" evidence="1">
        <location>
            <begin position="30"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="15248" checksum="6C982F7894BE777F" modified="2011-06-28" version="1">MVPPKKSKRVLFIVLGVVLALCCSGGAVGAFLIYRVAMDATGPVRSTVNTFAGALVERDYPTAYQQLCTRVRDRVSEADFTRQQETQPDLTGHKIVGLNLSNQNGHVSGSATVRYTASEGGTTNRVYPLIKEEGNWRVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE07</accession>
    <name>F4FE07_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LVIVD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18870"/>
    <dbReference type="EnsemblBacteria" id="AEB44876">
        <property type="protein sequence ID" value="AEB44876"/>
        <property type="gene ID" value="VAB18032_18870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18870"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023239_0_0_11"/>
    <dbReference type="OMA" id="AYWHSAS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313831" evidence="1">
        <location>
            <begin position="35"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="552" mass="58057" checksum="1B432815F8FF563E" modified="2011-06-28" version="1">MSQPTARGKRRAILGLAATGALLLSTVAAAPASAAANVIPGVDEIVSSANLTQIANVPKFGGFAAESSYNSDLAFQGDHVFAGNYNGFTVYDVSTPASPQVVSQVVCPGGQGDPSVFGNLLFFAVDSPRSDDSCSSGSGSVANAAHWEGVRIFDVSDKANPQYIKSVRTDCGSHTLTLAPSKDGKDVYVYVQSYSPSASAAYCRPPHDKISIIKVPVANPTSASVVATPVLFPDGGNTNTSGCHDITVYPELDLAAGACMGDGILMDISDRENPVVLSKVRDTNFAFWHSATFNNAGTKVLFTDELGGGSGAICTSNYRTNQGANAIYDIVGSGANRQLVFKSYFKIPRENSTRENCVAHNGSLIPAMGRDIMVQAWYQGGISVIDFTDSANPFEIAYWERGPLSDTRNILGGSWSAYWNNGYIYSNDIQKGLDVLKLDDPRTNNARAIAFEELNVQTQPSYPSCTTVLRGRQNGSLTIKSGITCFDGVTQNGAIKVNPGAGLIVFDSKLNGSIQATGASVVSIVESSVNGSVNAPGATIRDTKVNGSVRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE32</accession>
    <name>F4FE32_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733556.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18995"/>
    <dbReference type="EnsemblBacteria" id="AEB44901">
        <property type="protein sequence ID" value="AEB44901"/>
        <property type="gene ID" value="VAB18032_18995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18995"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310990_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="28"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="540"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="945" mass="102839" checksum="A8A765544D395CB2" modified="2011-06-28" version="1">MPFTDVVIPVEWASEPLAPAEFTGSGATTAPLTWAQQVLWRSISRFGSNHRFLNLRRTVGVSARAATDVPTALRAVGALVGRHAALRTRLPLVDGEPRQEAAADGVLPVLLCPGVGDGAEAARAAADRLADVAFDHAAEWPLRVALVTVDDRVRQVVLVFSHTTVDAHAAEVVMRDLRLLLLRGRLPTPPGPQSTDVARLQHGPDRRRSDRAAAYWLREYRRLPPEPWEQTGPGLDPPARRGVLVSSAIDTAARMVAARHRVSASAVLLAAYHAVAARHSGRTLVGLYPMAHNRFRTEYANAVANLGQVGFCVVDLTGRPDFTEVLSRVWIASLNGLRHAYYHSASLRGTFEEQGIDFDSLFGPHYYFNDVRMSVGGGPTPPVATPADLRAAMAASTFSWTEGLEQTAWHMLAHVVDEPGGVGITLTADTRHIAMDAVQTHLREMEELVVAAAHTDVPWPWSPPVTGAPSATDAPAEAGVVTVVADGEEIVSAPFAGGRAANAPLTWGQRAMWRSLDEFDSPAGYRALRLPRQLPVPARAELTVARAVTAIGALVSRHESLRTRFRRRDDELHQEAAAAGELPVLVHPVEQPEADPYGRKAAAGLTARLGTPRFDHVAEWPLRAALVTVDGRVRQVVVVFSHATVDFHASDLVLRDLRALLAGARLTAPGLQSLALAGRERDVEQRRSQRAVAYWVRQFAGLPPSLSEAVGPAPEPRYRRGSLVSPAVHHAVRLIAARNRTSTANAILAATAARLTGDSGQRACGIVVMANNRYQPGHAQAIGTLNQIGLCRLDLSGRPGFTELLSRTGRAALDAYRHAYYDPAVWERTFTDLGHDHPTFLAPYCYLNDARLLREVDPPPTGPDEATLRALVPEGHFRWLAELEQFPWRCRLQVLDADDAVELVVTADTRYFPAQRVEPFLRGIESLLVEAAHRDMPWPWSVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE94</accession>
    <name>F4FE94_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734812.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25310"/>
    <dbReference type="EnsemblBacteria" id="AEB46160">
        <property type="protein sequence ID" value="AEB46160"/>
        <property type="gene ID" value="VAB18032_25310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25310"/>
    <dbReference type="eggNOG" id="ENOG5031TCK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="GALWRKS"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="6871" checksum="678981D98A1D6E2B" modified="2011-06-28" version="1">MADTTTVRWRKSSRSGNQGACVEVADALPGGGVGVRDSKDPNSPVLTFSPTSWTTFTTSLRTPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEC2</accession>
    <name>F4FEC2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, rpir family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734840.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25450"/>
    <dbReference type="EnsemblBacteria" id="AEB46188">
        <property type="protein sequence ID" value="AEB46188"/>
        <property type="gene ID" value="VAB18032_25450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25450"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_0_1_11"/>
    <dbReference type="OMA" id="QEDTEIY"/>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="155"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="319" mass="33257" checksum="28B3E7CF39841DCC" modified="2011-06-28" version="1">MVDHEADTSAGTAVADADGVDRRGVGVASDGVLARVRAGVDELTGALRRVAEHVLSDPEAAARATIVELAERSGTSPATVTRFCRAMGFEGYADLRLGIAAETGRARSAGWSVDIGREIQPSDPLERVLEQIIVADTRAMHDTAALLDLGEVERAAVAIAGASRVNIFGASGSALVGEEMQFSLHRIGVAAWAWNDVHSGLAAAALLRPGDVALGISHSGQTREAIEMLAEGGSRGATTVALTGFRRSPLAELADIVLLTASQATTFRPDALSARHPQLVVLDLLYIAVAQRTHDRAHAAFRRTAQAVDGHKAARGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FED2</accession>
    <name>F4FED2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734850.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25500"/>
    <dbReference type="EnsemblBacteria" id="AEB46198">
        <property type="protein sequence ID" value="AEB46198"/>
        <property type="gene ID" value="VAB18032_25500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25500"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_4_2_11"/>
    <dbReference type="OMA" id="QVAWDAD"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="135" mass="13884" checksum="B4E2C588A6A4C9E6" modified="2011-06-28" version="1">MAVTLVNPSGLPEIDVYRQVSVATGSRIVHVAGQVAWDAEGRTVGEGDLAAQVEQCYLNVATALAGVGASFADVVKLTVHVVDWTPEQMPVLLDGIARAAAKLGDTPAAPASLFGVAALDVPEHLVEVEATAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEH0</accession>
    <name>F4FEH0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736047.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01640"/>
    <dbReference type="EnsemblBacteria" id="AEB47412">
        <property type="protein sequence ID" value="AEB47412"/>
        <property type="gene ID" value="VAB18032_01640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01640"/>
    <dbReference type="HOGENOM" id="CLU_2921497_0_0_11"/>
    <dbReference type="OrthoDB" id="2206990at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="6768" checksum="04E9B0E71D3B8433" modified="2011-06-28" version="1">MKTTTQPATRVLDLVLIGDGDDIAALTDIARRTGSLVFRSAPTATDDGRQRVFLRLHLHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FES5</accession>
    <name>F4FES5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06725"/>
    <dbReference type="EnsemblBacteria" id="AEB42469">
        <property type="protein sequence ID" value="AEB42469"/>
        <property type="gene ID" value="VAB18032_06725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06725"/>
    <dbReference type="eggNOG" id="ENOG50329W0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064711_0_0_11"/>
    <dbReference type="OMA" id="VFAHRGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="275" mass="31128" checksum="4EA37102CFF61D23" modified="2011-06-28" version="1">MLMMQIALSAVLPDVSRAAVIWLSLLGIVVLAVSGLLLRPRRLRFDAGARIREAALPIPPEQREEDRWAEEVMVAADRAEATARRRRDEWLVAQDEAEQAWEAYQTAEADVRRLAEAASMPLPHTPRTPAEYADRERWLHRAVLDAYWRRELSVEQLSDVFAHRGWDPRLHPVQQELVLRRAIRDHLFARQRVAREREQEAWHAAEVAAAAARNLRAETTTALLTADQQDSLLPLLPLTPLPDATPPPTTTEHANPEQTREIPPTPIARPAAPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEU1</accession>
    <name>F4FEU1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_06805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; L-ascorbate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731158.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06805"/>
    <dbReference type="EnsemblBacteria" id="AEB42485">
        <property type="protein sequence ID" value="AEB42485"/>
        <property type="gene ID" value="VAB18032_06805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06805"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003896_4_3_11"/>
    <dbReference type="OMA" id="FGSAYRW"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="UniPathway" id="UPA00132"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="45726" checksum="892F1A8CF08CA628" modified="2011-06-28" version="1">MSRPFVNWSGSLSFTPAERVEPADEDEVREVILRARESGRTVRPVGSGHSSSPLVRTDGILLSLDEMVGVVDQADERATVRGGTRLKALGEGLYEAGLAMDNLGDVDYQSIAGATATGTHGTGLGFGNLSTQVTEVRLVTGTGETLDISAKSNPDLLPAARLSLGALGVVTQLTLDVQSRYELHRRAWCAPVDWTLDHLAELQHTNRNMDFYWYPRSDLTQVRTMNRADEAPDDHRWATRQMLEAGPEGQFRDVDVGPTHQTIPQNRELRFEEIEYMLPSEAFPACFAEVRRRILARHRRYVGWRVLVRTIAADDIWLSNAYGRPTTTIACLQNTTLPYEDYFRDMESVFRHYGGRPHWGKKHWMTAPDLRPLLPRWDDFQAVRRRLDPDGVFLTPDLARLLEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEW2</accession>
    <name>F4FEW2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731179.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06910"/>
    <dbReference type="EnsemblBacteria" id="AEB42506">
        <property type="protein sequence ID" value="AEB42506"/>
        <property type="gene ID" value="VAB18032_06910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06910"/>
    <dbReference type="eggNOG" id="ENOG5032T5A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003934_0_0_11"/>
    <dbReference type="OMA" id="IMQENEY"/>
    <dbReference type="OrthoDB" id="1956573at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="29019" checksum="F80280A4D9F6E378" modified="2011-06-28" version="1">MDGQQLREALRDEMASVSSPPPLDTQTMLGSARRARNRRRTVRACVGSAAAVVAVGFFGTFAVPGAGGWSPAMIGAPSSEDDTASPWPTGPDGLPQQDRTARAGTRYDRGAELLDQLRAVVPAGYTVPESPEVPSHQAQYEQSIDEVDVWSYSSEVTLAKGEWTGRVMVEVHTAGNQLSTEPCKLARQFWGMQGDCEVVTVAAAQVGVVVNPGDDDRFDQWAAYRHPDGVVVFVAQATNHDSTLQSRPELPFSVPQLASLATNKRFHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF13</accession>
    <name>F4FF13_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13055"/>
    <dbReference type="EnsemblBacteria" id="AEB43725">
        <property type="protein sequence ID" value="AEB43725"/>
        <property type="gene ID" value="VAB18032_13055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13055"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042273_0_0_11"/>
    <dbReference type="OMA" id="WITIGAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="432" mass="44286" checksum="97013D7A4A018881" modified="2011-06-28" version="1">MGTPAFVRSSPYWPVVRHRILRRLLPGFALSYLGEGMALLAVSWLAIQLAPRANAGVWVAAAVAAYTLPGALGTVLFARALSGRSGAQLAAWDAVLRAVMLGAIPVVHLAGALDIRWFTLLLGCSALLRSWGSAGRFTLIAELLPVEHRLAGNALIGLFSEASTLIGPALAALLIAAAGPVLVIAVAAGTYAVLAVSYLIAVPRAARAPIEQRQASSLAGFAAIWRDRPLLGLSTLTFGFFFLYGPVQVALPIHVAESLGNSAGTLAAFWTAFGAGALIGGFAAGYLRRWRLWPTIIAIVVGWGAALLPLGLGAPTGVALVAIAIGGLIWAPYPAATMALLQRSTDGAGRAPVLAAYAAIATLSVPLGTITAGPLITGVGAEFTILAAAVLTVAFGVIAAAIAIWRAVKGRTVGPVSSDVSQGEQTLIKAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFI8</accession>
    <name>F4FFI8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734941.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25960"/>
    <dbReference type="EnsemblBacteria" id="AEB46290">
        <property type="protein sequence ID" value="AEB46290"/>
        <property type="gene ID" value="VAB18032_25960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25960"/>
    <dbReference type="eggNOG" id="ENOG5033IPK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150079_0_0_11"/>
    <dbReference type="OMA" id="GPYEWSR"/>
    <dbReference type="OrthoDB" id="1759285at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="111" mass="11710" checksum="7BCD271899242473" modified="2011-06-28" version="1">MADGSDTTLTAEQTPSGSAPNGLVAGIRSFAAGHGGAKAVIEYVGKRGARIVLVGSDGAWGDQFAEDTVVAREACAQAGVAVENAWERELMDQMRPSNDLWRSMARRTMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFJ3</accession>
    <name>F4FFJ3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ordered locus">VAB18032_25985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734946.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25985"/>
    <dbReference type="EnsemblBacteria" id="AEB46295">
        <property type="protein sequence ID" value="AEB46295"/>
        <property type="gene ID" value="VAB18032_25985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25985"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_1_11"/>
    <dbReference type="OMA" id="VEICVYE"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="208"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="504" mass="56430" checksum="D93757CBF2EFBDC5" modified="2011-06-28" version="1">MNPLRDPQDRRLPRIPEPCALVIFGVTGDLAQKKLIPAVYDLANRGLLPPGFVVVGFARRDWADGDFATLAREAAKAHSRTPWREEVWSRLEHNIKFVGGSFDDDAAFDRLTECLNGLRDSHGIHGNVAFYFSIPPAAFPVVLKQLARTGMADNDKCGGWRRVVVEKPFGHDLPSAKALNDLVDDVFTRRDVFRIDHYLGKETVQNILALRFANSLFEPLWNSQYVDSVQITMAEDVGIGSRAGFYDSVGTARDVLQNHLLQLLALVAMEEPTSFDADEIRAEKLKVLKAITLPKDVSQGTVRGQYLPGWVGGQRAKGYLEEDGVPPTSTTETYVAVRLGIQNRRWAEVPFYIRAGKRLPRRVTEVAVMFKRAPHLPFNSTDMEMLGNNQLVIRVQPDEGVVLKFGSKVPGTTMEVRDIAMDFQYGEAFTESSPEAYERLVLDVLIGDRTLFPDAAEVEQSWAVVDPLEHAWEGTKPEPYRAGEWGPRAADTMLAREGRAWRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFV8</accession>
    <name>F4FFV8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731211.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07070"/>
    <dbReference type="EnsemblBacteria" id="AEB42538">
        <property type="protein sequence ID" value="AEB42538"/>
        <property type="gene ID" value="VAB18032_07070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07070"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127592_3_0_11"/>
    <dbReference type="OMA" id="CHDDQGS"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="12665" checksum="64B8B8688F306BB9" modified="2011-06-28" version="1">MAGEPSFIEFAVPVPERTRDFYEALFGWKFTMLTHGSYIEMPGAPAGLEAGSHPDTDPPHIIVYFAVDDLAAAVERVKELGGEVGPLRPPSPDYGAFAECRDNQGVAFGLRELPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG75</accession>
    <name>F4FG75_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13535"/>
    <dbReference type="EnsemblBacteria" id="AEB43819">
        <property type="protein sequence ID" value="AEB43819"/>
        <property type="gene ID" value="VAB18032_13535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13535"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107471_1_0_11"/>
    <dbReference type="OMA" id="WTEYLHI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="95"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="174" mass="18118" checksum="61F0D72C7E7B9A4E" modified="2011-06-28" version="1">MLALAEEAAHLDARLPVLLTGMGKINAASAVAATLARTPLPAAVINLGTAGALHPGWAGTHEVGSVLQHDLDTDFLRRLTGQSVGAPLALGDGPVLATGDQFIADDDARAALATRAHLVDMEGYAVASTAQRFGVPVRLIKQVSDEAGDGAARTWQESVDQCARLLADWVRDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGB6</accession>
    <name>F4FGB6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733709.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19760"/>
    <dbReference type="EnsemblBacteria" id="AEB45054">
        <property type="protein sequence ID" value="AEB45054"/>
        <property type="gene ID" value="VAB18032_19760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19760"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044949_0_0_11"/>
    <dbReference type="OMA" id="AELTFAY"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="343"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="409" mass="44213" checksum="7EAD0EA77FF7E9CC" modified="2011-06-28" version="1">MADISGTTHRASRLELEQRVARELRDRLPLVAAQTVSAITAEVPSYSGTLTGQMRDKIENAVQIALGTFLQLLERPQTSAASTPLVPALEAAYALGSGEARSGRSVDALLAAYRIGARVSWREMAAASVALGLPAATVAEFAELMFAYIDELSAASVAGHADELASAGRAQRRNLERLTQQLLAGEPEEVLLRSAERAGWQVPETLTVALLPQAKLRGALALLDEHTLESSEELPAGEPGEETAVLLVPDMHGDRRRQLARVLHGRRAVLGPARPWAHVSSSYRRVVRVVGLGIAQPPDGEPLDTDRHLAELLLSADMEALTDLRARVLQPLADLPSATAERLAETLRSWLLHQGRRDDIAADLFVHPQTVRYRMGQLRQLYGERLTDPRSVLDLTVALALPTGIATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGF4</accession>
    <name>F4FGF4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733747.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19950"/>
    <dbReference type="EnsemblBacteria" id="AEB45092">
        <property type="protein sequence ID" value="AEB45092"/>
        <property type="gene ID" value="VAB18032_19950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19950"/>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037618_3_0_11"/>
    <dbReference type="OMA" id="RPFPNNW"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="30096" checksum="B4A9F28D534E36A1" modified="2011-06-28" version="1">MALIRCDFFAETLGLSTSMTVILPQRTESQIGLTGADVPGDPPVLYLLHGLSDDDTIWLRRTAIERYVAPLGLAVVMPQVGRSFYADEEHGNRYWTFLREELPQLCHGFFRLSARREDTFVAGLSMGGYGAVKWALREPDRFAAVASLSGALDLAFRAEHPTRPIDPRVWHTAFGDRPVRGTDDDLLTLLDSAAAAPPLYVACGTEDFLYEDNVRFVERARSVGLPLTVDFSPGEHDWAYWDAKIADVLAWLPLADRGGQPTEERATGRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGK2</accession>
    <name>F4FGK2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsA</name>
        <name evidence="3" type="ordered locus">VAB18032_26195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734988.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26195"/>
    <dbReference type="EnsemblBacteria" id="AEB46337">
        <property type="protein sequence ID" value="AEB46337"/>
        <property type="gene ID" value="VAB18032_26195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26195"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_4_1_11"/>
    <dbReference type="OMA" id="WQQFART"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="126"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="297"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="495" mass="54851" checksum="45DF0571AAF66FB2" modified="2011-06-28" version="1">MTSSIEAPSSATKVTVDDLGSEEAFLAAIDETIKYFNDGDIVEGTVVKVDRDEVLLDIGYKTEGVIPSRELSIKHDVDPAEVVSVGDHIEALVLQKEDKEGRLILSKKRAQYERAWGTIEKIKDEDGVVRGSVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYVGRELEAKIIELDKNRNNVVLSRRAWLEQTQSEVRTEFLNKLQKGQVRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGQEVEVEVLDVDLDRERVSLSLKATQEDPWRQFARTHAIQQIVPGKVTKLVPFGAFVRVDDGIEGLVHISELAERHVEIPEQVVQVGSEVMVKVIDIDLERRRISLSLKQANEGFVEGEEHFDPTLYGMAATYDAEGNYIYPEGFDPETGEWLEGYDKQREAWENQYAEARQRWEAHQKQVQTSRAAEAEAAANPQPAATGTTTTTSAAPSRQAEEPAGTLATDEALAALREKLAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGN7</accession>
    <name>F4FGN7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26370"/>
    <dbReference type="EnsemblBacteria" id="AEB46372">
        <property type="protein sequence ID" value="AEB46372"/>
        <property type="gene ID" value="VAB18032_26370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26370"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054560_0_0_11"/>
    <dbReference type="OMA" id="GNDMTWE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="28"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="367" mass="40371" checksum="65C7CFA16F1055E3" modified="2011-06-28" version="1">MSITAPAAAQPLESHCGNETGGKSVQGFISHEELRRSLQQIEHTSNGKVQVDVAGYSNQGREIWTARVGEGDTVVLVQSQIHGNEMHGTAAVLDALRTLGNNSKRSEEIRKAVTIVAIPKLNPDGSEADVRQNQRTWSDVVADFPQLADARTAWNYNTRVGGFDVNRDFNPNLDYVPQAAHFPGNSASTGWYITPEAQTARDVYRALEQEFGTVDIFADLHNQAACYTGEGMDDYTTLSISGRFINNPAQHGNWPKFNYDASRRVNVAVYDALQSGNSPQSKVTLYPQNTNLPGTALGSFALRGSATILFETRGQTQSWGQKQHGMLTKQVEDGLFGIFNAITDGTLNTIDPERYELIPERRNVPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGR0</accession>
    <name>F4FGR0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736203.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02430"/>
    <dbReference type="EnsemblBacteria" id="AEB47570">
        <property type="protein sequence ID" value="AEB47570"/>
        <property type="gene ID" value="VAB18032_02430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02430"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026366_0_0_11"/>
    <dbReference type="OMA" id="HGFHAFF"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="508" mass="55288" checksum="A21CB4FE461EE656" modified="2011-06-28" version="1">MALSQVVGRLLGVRRHEVTSGGSGLPRVPQPVSALVVGGGIAGMSAAVVLAERGVEVTVLEAAPTLGGRLGAWPQTLDDGSRQVNEHGFHAFFRQYYNWRNILRRIDPKLRFLRPVPSYPVLSAQWPTEEFGRLPPAPPANLLTLLARSPSVRLRDLRGMDRDAALPLLTYHPTRTYAEFDERTADDLLTSLRLPDRARAMLFEVFSHSFFNHEAQMSAAEMIAQFHFYLLGNPEGLAFDCPEDDYATTIWAPLTRHVERHGGRVLTGVVATGLHQEQAGWRVTATEGAYRAGHVVLALDPPALAALVAASPGLADAAPQLVAAMPAFGRPGPPYAVARYWCDGDVAAQRAVFSGVTRQSTLDSVTLYHRLEHGSRRWAEQTGGCVLELHAYACEPDVPATELAARMWAELTTLWPEVSRLRVRELHARVEAKAPAFAPGGHARRPGVRTDADRLYLAGDGIHTDFPSALMERASATGILAANHILRSAGAATEPLWSVRPRGLLARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH69</accession>
    <name>F4FH69_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase GroES domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732514.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13675"/>
    <dbReference type="EnsemblBacteria" id="AEB43847">
        <property type="protein sequence ID" value="AEB43847"/>
        <property type="gene ID" value="VAB18032_13675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13675"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_11"/>
    <dbReference type="OMA" id="GPWGCGT"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="2"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="348" mass="36055" checksum="8BC4B8E4A9CDC917" modified="2011-06-28" version="1">MRALRLPAWKSDPELVEVDEPTPGPGEVVVKIGGAGACHSDLHLMHDFEAGSLPWNPPFTLGHENAGWVHALGAGVTGLEIGQPVAVYGPWGCGVCARCRVGAENYCENPAAAPIPGGGGGLGLDGGMAEYELVPAARLVVPLPEGLDPVLAAPLTDAGLTPYHAIRRSWAKLPPGSTAVVIGVGGLGHIGVQILKATTATRIIAVDTRDEALQLAEECGADQTLRSGERTVEEIRSATGGRGADVVLDFVGADATMKMGAAAARTVGDLTIVGIGGGSLPVSFFSVPYEVSIQTTYWGSRPELIEVLDLGARGLLRPKTTTFSLDDAMSAYRKMQDGTLEGRAVIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH76</accession>
    <name>F4FH76_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732521.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13710"/>
    <dbReference type="EnsemblBacteria" id="AEB43854">
        <property type="protein sequence ID" value="AEB43854"/>
        <property type="gene ID" value="VAB18032_13710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13710"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609394_0_0_11"/>
    <dbReference type="OMA" id="CQESWHP"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309338" evidence="1">
        <location>
            <begin position="33"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="43839" checksum="71B0C8EA53EEB251" modified="2011-06-28" version="1">MSGLRRTAAAMALAVAAATLSTAVTTAAPAAAALPTAAVALGDSFISGEGAGAYQPVVDSTGVARSFPGWTAANSNAFFCHRSANASLHKASLPGIQDRFNLACSGGQPHDIAAASSARTSGRQVAAQLDQLRAVARTHDIDLVLIGLGSNNSSFTFGGVAEKCANRFIADAWTGWWEFWAYLNGPVEQKPCTDADLATAAQISAATAETTAAVRQILTTLREVDADGQHRVVLQDYTNPLPLDLASPYHSEDSRDDTRDKFRALGAERYAAGCPIHRASLAPGHRFSQGLGTIVRSTRDTLAAEYPGADLVYLNVQRAFDGARLCETSNSPTGTLATPIRLMDNPPNGTFVTSLSGKDKIAIQRIANTCVTYFQTCQESWHPNAAGHQVLGQCLAGAATTTARSVACVRASNGTISVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHA2</accession>
    <name>F4FHA2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_13840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13840"/>
    <dbReference type="EnsemblBacteria" id="AEB43880">
        <property type="protein sequence ID" value="AEB43880"/>
        <property type="gene ID" value="VAB18032_13840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13840"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="VHIVYRV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="51"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="29478" checksum="E891F18F5AC69B32" modified="2011-06-28" version="1">MVDHLAMSNDVTVTLPRIQDRIPTVVVDDAHVVYRVHKGAAGSHSPVAALRRLVTRTSTPNVREVHAVRGVTFTAYRGEAIGLIGTNGSGKSTLLRAIAGLLPVERGAVYTEGQPSLLGVNAALLNDLSGERNVTLGCLAMGMSPAEVQRQLPEIIEFSGINQRGDFASLPMRTYSSGMSARLRFSIAAAKQHDVLLIDEALATGDKRFRKRSEARVRQLRENAGTVFLVSHQLSSVRDTCERTIWLESGVIKMDGPTDEVLKAYEAFTSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHP0</accession>
    <name>F4FHP0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ordered locus">VAB18032_26681</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735060.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26681"/>
    <dbReference type="EnsemblBacteria" id="AEB46409">
        <property type="protein sequence ID" value="AEB46409"/>
        <property type="gene ID" value="VAB18032_26681"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26681"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_11"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="OrthoDB" id="1522718at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="26271" checksum="42824B83A5E48641" modified="2011-06-28" version="1">MTVAVRVIPCLDVDAGRVVKGVNFLDLRDAGDPVELAAAYDRAGADELTFLDVTASSSDRGTMLDVVRRTAESVFIPLTVGGGVRAVADVDTLLRAGADKVGVNTAAIARPELIAEIADRFGRQVLVLSLDVRRAPAGTTPSGFEVTTHGGRRGTGLDAVQWAQRVAELGAGEILLNSMDADGTKAGFDLELIGAVRRVVDVPVVASGGAGEVAHFPPAIGAGADAVLAASVFHFGELTVGEVKDALRTAGHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHQ2</accession>
    <name>F4FHQ2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_26741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735072.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26741"/>
    <dbReference type="EnsemblBacteria" id="AEB46421">
        <property type="protein sequence ID" value="AEB46421"/>
        <property type="gene ID" value="VAB18032_26741"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26741"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_11"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="97"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="33820" checksum="8DCF20021101DBCC" modified="2011-06-28" version="1">MTGTFAAGGDHRSLPVPDGLDGMRLDQAVARLFGLSRTAAAALVDAGEALVDGAVRPNSHKVRAGAWLEVTLPAPAAAPVVVPQAVPGLRVVYADDDIVVVDKPVGVAAHPSPGWTGPTVIGGLAAIGHTIATSGAAERQGVVHRLDVGTTGVMVVAKSEQAYSALKRAFKYREVEKRYHAVVQGHLDPLRGTIDAPIDRHPHHDYRWAVVSDGKPSITHYDTLEAFPSASLVDVRLETGRTHQIRVHFSTLRHPCVGDLTYGADPTLSARLKLDRQWLHARELSFEHPRTGDEVRFVSDYPDDLGRALEILRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI02</accession>
    <name>F4FI02_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03055"/>
    <dbReference type="EnsemblBacteria" id="AEB47695">
        <property type="protein sequence ID" value="AEB47695"/>
        <property type="gene ID" value="VAB18032_03055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03055"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_4_0_11"/>
    <dbReference type="OMA" id="PVRFACP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="70"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="317" mass="33995" checksum="43A42AB95F93E2C5" modified="2011-06-28" version="1">MSAVRRSFSVLMDAQTTLIAMRKRTLFRLATATVATGAAALAYASLVERNMFTLRRFDVPVLPAGTEPLRVLHLSDLHMTPNQVRKQHWVASLAALDPDLVVVTGDNMAHPEAVPGVLRALQPLLDYPGAFVFGSNDYTGPVWKNPFSYFLPDREYTEGVELPSEELRDVLIGAGWADLNNRRSTVKAGGRAIDMAGVDDPHVERDDYTAVAGPVSASADLSIALTHSPEPALLDEMAADGFALLLAGHTHGGQVCVPGVGALVTNCGLPRSMAKGLHRWPGSDAWLHVSAGLGTHPTAPVRFACRPEASLLTLIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI32</accession>
    <name>F4FI32_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_30164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
            <plasmid evidence="3 4">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713118.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30164"/>
    <dbReference type="EnsemblBacteria" id="AEB47996">
        <property type="protein sequence ID" value="AEB47996"/>
        <property type="gene ID" value="VAB18032_30164"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30164"/>
    <dbReference type="eggNOG" id="ENOG5032GQH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637674_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="430" mass="44323" checksum="E84B6C7F98427F6B" modified="2011-06-28" version="1">MIFFDILVWLAVAKFAVLLLEDAAYAVRGKQSPRRQARARHQAAQQKTSDSGTSTDGPAGGRRRSGGTTLGAADGYLAGLIEDATERARARRRRAAARKRGAQAVDGVVVDVDDQGRWYADCDVCGWHSRPYRIEANALGAGRAHTRTEHPDQYTGQPEPTEATKTAEATEAAEGDSAESPAPAPADIDVAEESGRPALRVIPGGAQDTPPTRPAGPAGDPKPADAAPVTTPAAVLPSLARYGWRCPHCGARKEGFVSFGAAEAAAGAHTCPTTPTDPAPGTGHQDSGTAAGDDQHHPTGVPMAPDGSTTSTNDSKELHVNLEATGPDEIRAAFTQAAESAGENAETLGGIAGVLTEAADRYESLEMAASTVGHLRDAAEQFASAQAALNTAQEELQAALADFNAKDGQVADTVTETGGNVASKEVLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI59</accession>
    <name>F4FI59_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_30299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
            <plasmid evidence="3 4">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30299"/>
    <dbReference type="EnsemblBacteria" id="AEB48023">
        <property type="protein sequence ID" value="AEB48023"/>
        <property type="gene ID" value="VAB18032_30299"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30299"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037105_0_0_11"/>
    <dbReference type="OMA" id="PEVWMAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313975" evidence="1">
        <location>
            <begin position="39"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="243"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB48023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="378" mass="39920" checksum="4E9065CA017167BC" modified="2011-06-28" version="1">MTRKPIALAVAVVAVVVLLCGGTVVLPVLMFGQEQAEAAACEVPLLPDAAAPDVGRWSGAQVANAVVIVTAGRQRQVPARGYVIALATAMQESTLRNLANANVPESLALPHEGVGRDHDSVGLFQQRPGWGTVRERMTPSYAADRFYEALARVDGWERMRLTDAAQAVQRSAYPEEYQKWEDDAELLAAAVLGVPDIRDIGGGAPTAPCGVGEFGPVPVGPGGWVQPLHAFVGSPFGPRNGRLHAGVDMSKTDVRGDPIRAASGGVVERVTCDWYTTCDRDGHTRARGCGWFVDIRHPGNIVTRYCHMIQRPEVAIGDSVAAGAVIGFVGNSGGSSGPHLHFEVHVNVPAGPYNVTPSNAVDPVPFMRARGAPLGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F116</accession>
    <name>F4F116_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trypco1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731343.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07750"/>
    <dbReference type="EnsemblBacteria" id="AEB42670">
        <property type="protein sequence ID" value="AEB42670"/>
        <property type="gene ID" value="VAB18032_07750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07750"/>
    <dbReference type="HOGENOM" id="CLU_137386_3_2_11"/>
    <dbReference type="OMA" id="MAYYLEV"/>
    <dbReference type="OrthoDB" id="2018524at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045794">
        <property type="entry name" value="Trypco1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19493">
        <property type="entry name" value="Trypco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12270" checksum="8578C64281BB8D00" modified="2011-06-28" version="1">MAYYLEVPLTDGGTILFDITSRVEGVVPAGKQEVVERMGESLERVLDRLQPVTEALVGRLTRLRDSPDRVAVEFGVSLSGKTGVVIAEASTQAHFTVTVEWNRGRGQQPTAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F165</accession>
    <name>F4F165_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_08005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731392.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08005"/>
    <dbReference type="EnsemblBacteria" id="AEB42719">
        <property type="protein sequence ID" value="AEB42719"/>
        <property type="gene ID" value="VAB18032_08005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08005"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="TERMTAY"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="22681" checksum="EFC1008D307A6ED7" modified="2011-06-28" version="1">MSEQARVLIVDDHPVVRRGLRTMLEGESWVAEVLEAASCAEAIAAVAHEQVTVVAMDIALPDGDGVQAVGQILRHRPETAVVMLTMADEDELVARALRVGARGYLLKDTDPDLVVDALRTVAGGGVVLGPGITAAALGRAQPATVSLPPPFDRLTPRERDILAHLAAGEDNAQIARRFGLSTKTIRNQVSAILGKLGVADRVQAALLARDVGIGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1N3</accession>
    <name>F4F1N3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fha domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733916.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20810"/>
    <dbReference type="EnsemblBacteria" id="AEB45262">
        <property type="protein sequence ID" value="AEB45262"/>
        <property type="gene ID" value="VAB18032_20810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20810"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108862_0_0_11"/>
    <dbReference type="OMA" id="IGKFRLT"/>
    <dbReference type="OrthoDB" id="1632705at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="16140" checksum="4D8CDBCA7C05119C" modified="2011-06-28" version="1">MTRPGDEFPPLDVTSTLNLGSLEEALEGPDTDVVPSRMSGSLPPGMALLVVRRGPNAGARFLLDHDVTTSGRHPDSDIFLDDVTVSRRHAEFHRDGGTFTVRDVGSLNGTYVNRERVEAATLTNGDEVQIGKFRVVFIAGPRPEGEAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1T2</accession>
    <name>F4F1T2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ste24 endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_27171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735157.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27171"/>
    <dbReference type="EnsemblBacteria" id="AEB46507">
        <property type="protein sequence ID" value="AEB46507"/>
        <property type="gene ID" value="VAB18032_27171"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27171"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_1_1_11"/>
    <dbReference type="OMA" id="LPFKIYK"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="11">
        <location>
            <begin position="75"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="212"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB46507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="418" mass="44263" checksum="75EFD2E56D911BD7" modified="2011-06-28" version="1">MSPRGWAVLTLAGLGLAVLVAALVLIPWNRPPAPRADQLAALRDLPADQVERARQFRSALRPGSWAALGAGLLVALALGLTPLGSRLIELAGRPFGDHWTAQAILGGLAVVLVADLVTLPFAAWRHSVLTRWGLATNGWAGWAVDLLKSYAVSAVIGAVALLGFYTVVRLAPRWWWAFGAAGAATLVVLLSFVLPVLVEPVFNRFSPMEPGPLRTQLMDLAARDGVPVRDVLVADASRRTRAVNAYVSGFGPTRRVVVYDNLLREATDAEVTAVVAHELGHAKDRDVPVGTLTGALGAAAAVVALYLIGSWPPLLRLAGVGSVAEPRAFGLLLALVTVAGLVFAPAQALMSRRVEARADAHALALTGDPAAFESMQRRLSSVNLSDPDPPRWEYLYSASHPSTVERIAAARAYARKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1U6</accession>
    <name>F4F1U6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ordered locus">VAB18032_27241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735171.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27241"/>
    <dbReference type="EnsemblBacteria" id="AEB46521">
        <property type="protein sequence ID" value="AEB46521"/>
        <property type="gene ID" value="VAB18032_27241"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27241"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_4_1_11"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="81"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="115"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="35868" checksum="A639D123D0EB62A6" modified="2011-06-28" version="1">MGERTWPHLLTALLRGEELSAADTAWAMGEIMSGAAAPVQIAGFAVALRAKGETPAELGGLVEAMLSRAVPVGLPEQVRASALDVVGTGGDLAHTVNISTMTALVVAGAGVRVVKHGNRAASSSCGTADLLEFLGVPLDLGPEQVARCVAEAGIGFCFAARFHPGMRHAGPVRRELGVPTAFNFLGPLTNPARPRAGAVGCFDATMAPVMAAVFAARGDSVLVMRGEDGLDEFSTAAPTRFWVAQGGTVREALVDATDLGVPRATLADLRGGDAAYNAQVAHRLLAGESGPVRDAVLVNAAAALATQGPLDGDLTTALRAGLDRAAESIDSGAAARTLDHWIKVAQSIQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Z7</accession>
    <name>F4F1Z7_MICM1</name>
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        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_03300</name>
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        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47744.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
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    <dbReference type="STRING" id="263358.VAB18032_03300"/>
    <dbReference type="EnsemblBacteria" id="AEB47744">
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    <dbReference type="eggNOG" id="COG0506">
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    <dbReference type="HOGENOM" id="CLU_061158_0_1_11"/>
    <dbReference type="OMA" id="KWGLRFG"/>
    <dbReference type="OrthoDB" id="1746057at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
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    <dbReference type="Proteomes" id="UP000008308">
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    <dbReference type="GO" id="GO:0000166">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:proline dehydrogenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proline catabolic process to glutamate"/>
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    </dbReference>
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        <property type="entry name" value="Proline_DH_dom"/>
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    </dbReference>
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        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="44"/>
            <end position="300"/>
        </location>
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            <position position="98"/>
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        <ligand>
            <name>substrate</name>
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        <location>
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        <ligand>
            <name>FAD</name>
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        </ligand>
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        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
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        </ligand>
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        <location>
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        </ligand>
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        <ligand>
            <name>substrate</name>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="309" mass="33433" checksum="247D941AE4D0F20B" modified="2011-06-28" version="1">MLRQVILKTAASRRARRAIEATPLTRAVVDRFVAGENVPSAVRASEGLNDAGCLATLDYLGEDTTDRAHAEHVTGQYVALLDGLADAGLTGMAEVSIKLSALGQALPREGEAVALDNASRICAAAARAGTTVTVDMEDHTTTDSTLGIVAQLRRDFPETGAVIQAYLRRSEGDCRDLATAGSRVRLCKGAYREPASVAYQARAEVTQAYLRCAEILLAGPGYPMLATHDPELIVAGTRLAAGRPGGVTGYEFQMLYGIRPTEQRRLAEAGHQVRVYVPFGEEWYGYLMRRLAERPANLMFFFRALTSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F217</accession>
    <name>F4F217_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03400"/>
    <dbReference type="EnsemblBacteria" id="AEB47764">
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        <property type="gene ID" value="VAB18032_03400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03400"/>
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    </dbReference>
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    <dbReference type="OMA" id="KWPFLTE"/>
    <dbReference type="OrthoDB" id="1593423at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="380" mass="40772" checksum="8059809A1B40D4C9" modified="2011-06-28" version="1">MKHRAVGAVLFGGGVLLLALAAGLVFVVKPAMTKLPYDLDPSTSVAEAKGATFLQITNGAVDIDQADLKSTILVTPERDKTAALSGDLAGDTVVWRVGQTVDRTDTKELVSAYGAELALDRVSGAAVEWNDQFLDDSGTPEKVSFAGQVYKFPFNAEQSNYEVFDRDLRQTRMAEFKGTEEIEGLETYRYEQVITDEKLPLPAERIALLLGALVPGATAGDIVYSNTRTVWVDPVTGSYIKVREQQKKVLTPNTGAPVTLLDADFVYNDETVTASADRAKSSRGQLAILGVWAPLALVVLGLALIVAALLFSRRPAPAAVGTHRAGADPAPTRVDQPAVRDDDRAAGPLTDEIPPASTNWRSEEPTVPLQRGTQGEAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F294</accession>
    <name>F4F294_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731454.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08325"/>
    <dbReference type="EnsemblBacteria" id="AEB42783">
        <property type="protein sequence ID" value="AEB42783"/>
        <property type="gene ID" value="VAB18032_08325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08325"/>
    <dbReference type="eggNOG" id="COG1832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_0_0_11"/>
    <dbReference type="OMA" id="IEHARFH"/>
    <dbReference type="OrthoDB" id="1910664at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="160" mass="17904" checksum="5A54CDB9184623E8" modified="2011-06-28" version="1">MFEIGRYQDVSTIQRALHTTRTIAVVGLSANQLRASNFVGYYLKRHGYRMIPVNPRETEILGERSYPSLADVPVPVDIVNVFRAPGALPQIAREAVAIKAKTLWTQFGVINEEGARIAEEGGLTVILDRCLKVEHARYVGRMHWLGFNTQRVTSVRGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2B0</accession>
    <name>F4F2B0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von willebrand factor type a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08405"/>
    <dbReference type="EnsemblBacteria" id="AEB42799">
        <property type="protein sequence ID" value="AEB42799"/>
        <property type="gene ID" value="VAB18032_08405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08405"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647068_0_0_11"/>
    <dbReference type="OMA" id="GWTPIGP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="410" mass="43243" checksum="BFD954DE10E0E3FB" modified="2011-06-28" version="1">MPASADDTAEPVTEPPRVQLVLDVSGSMRATDIDGRSRISVAQQAFGEVVDALPDETQLGIRVLGATYRGEDKQQGCLDTQQIVPVGPVNRERAKAAVATLRPTGFTPVGLALREAAKDLGGGTTARRIVLITDGEDTCAPPDPCQVARELAAQGTTLVVDTLGLAPDEKVRRQLLCIAAATGGTYTAATSAEDLTGRLKQLVDRARDTYATTPAKVAGADVCQGAPLLAPGVYTDRETFSEHRWYRVPVRPDQELRASVSVAMDRPVNPDYGVLLRATASDGRELVRGVDAGSGRTDVVSAGLRWSAGADDDEQSRAEDATPTPTAAATAVTTVCLVVSNMFSPRAGTEKEPGMPVELTVDVVAASPTPDGPDLGRGWVLLLLLTLAGLLTGLVTGLLTRWWVATWREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2U5</accession>
    <name>F4F2U5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_27416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735206.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27416"/>
    <dbReference type="EnsemblBacteria" id="AEB46556">
        <property type="protein sequence ID" value="AEB46556"/>
        <property type="gene ID" value="VAB18032_27416"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27416"/>
    <dbReference type="eggNOG" id="COG1090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047373_0_2_11"/>
    <dbReference type="OMA" id="YMPWIHI"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="299" mass="31935" checksum="0DEC6F69005BFBED" modified="2011-06-28" version="1">MRILMAGASGFLGTQLVDLLVADGHQVTRLVRRPPRTPDERQWSPSAAQLDPALVAEADAVVNLAGAGVGDRRWNDRYKQLIRSSRVDTTSTLAITIAGLPAADRPEVLLNASAIGWYGNTGDRVVEEDAPAGEGFLADVARVWEAATRPAEDAGVRVVRLRTGLPLHRDGGLLKPMLLPFKLGIAGRLGSGRQWIPWISMVDWLNATTYLLARADLAGPVNVVGPAPVTNAEFTRELARQLHRPAVIPIPGLALKVALGGFAQEALTSTRVLPGVLARASFTFRHPDLPSALAAALQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2V5</accession>
    <name>F4F2V5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_27466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735216.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27466"/>
    <dbReference type="EnsemblBacteria" id="AEB46566">
        <property type="protein sequence ID" value="AEB46566"/>
        <property type="gene ID" value="VAB18032_27466"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27466"/>
    <dbReference type="eggNOG" id="ENOG5033F8I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472298_0_0_11"/>
    <dbReference type="OMA" id="WAMLLRT"/>
    <dbReference type="OrthoDB" id="2025555at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="44"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="184" mass="19225" checksum="EAC16E4E7AE4993B" modified="2011-06-28" version="1">MTVRGFDRPPTRLEAAKAYAEQVWGTGSAKRVATFDNGIPYVRAGAVARFLTWFVDTVVCLFGVGVCVVALALLHDGGQGLSIDAVAVLAIASYFVVPMLYGLCYGNGRALGAVLTGTQLVRAKDGGRIGLKGCWAMVVRTVFMPIVFGIVVLSAATGLGVAGSLARTSIDRAATRHLHAAGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2W2</accession>
    <name>F4F2W2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase class-I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27501"/>
    <dbReference type="EnsemblBacteria" id="AEB46573">
        <property type="protein sequence ID" value="AEB46573"/>
        <property type="gene ID" value="VAB18032_27501"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27501"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_3_2_11"/>
    <dbReference type="OMA" id="TSMLHWH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="250" mass="26925" checksum="90D341CDF0A854BC" modified="2011-06-28" version="1">MIENDPTDDARRLGEWLTEAGLELSVVRPHAGDELPADLAGYAALVVLGGDQQAYPTTDGTPSAAWFPDVEALLRKAVRHRLPTLGICLGAQLLATAHAGAVERSPAGPEVGPAVVGRRDAAENDPLFRYVPLIPDVLQWHADEITELPVGATLLAASTRYPHQAFRLGDRAWGLQFHIECDTAMIADWATDSALLAELGYDRDLVVAACDAVMVDVEEVWQPFAVRFAALALGELDDDGPRRTLPLLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F338</accession>
    <name>F4F338_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_03675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736449.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03675"/>
    <dbReference type="EnsemblBacteria" id="AEB47817">
        <property type="protein sequence ID" value="AEB47817"/>
        <property type="gene ID" value="VAB18032_03675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03675"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="QSGNLIP"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24509" checksum="65757B0C3047F12D" modified="2011-06-28" version="1">MTAMLSLSDVTLIHGDGEDTVTALDKVNLEVEAGELVAIVGPSGAGKSSLLAVCGALISPTSGTIRLNDLDLSAQSPRRLTAIRRERIGFVFQSGNLIPSLTSLDQVRLPLTFGKVANPRDPRELLAEVGMSHKADRRPHQLSGGERQRVGIARALVTRPQVLLVDEPTAALDRQRSQDVVALLAREAHEHGVATVMVTHDHEVLHHCDRVLEMIDGRLLPAESNAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F356</accession>
    <name>F4F356_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein GntR, HTH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03765"/>
    <dbReference type="EnsemblBacteria" id="AEB47835">
        <property type="protein sequence ID" value="AEB47835"/>
        <property type="gene ID" value="VAB18032_03765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03765"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078241_0_0_11"/>
    <dbReference type="OMA" id="RPGQRMP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="24132" checksum="0BF646E6E5BC8533" modified="2011-06-28" version="1">MSRQGSGAFVRAQTQRAVELRPHIEAAFERPYVTIDFAGFSGETLRDALAEALDKVRVGRLAPETIAVRVLISDMAAPMALPSRAETQADDPAVRERAERITRRAADGIIDQVTELGDLGLVRSATVEVRMHRASPLFKLYILNGEEVFYGFYPVTERTVSIKGEPMAIYDLMGKDVPLFHYAVTDDDTSHGTQFVEASRQWFDSVWSTIAYRYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F359</accession>
    <name>F4F359_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03780"/>
    <dbReference type="EnsemblBacteria" id="AEB47838">
        <property type="protein sequence ID" value="AEB47838"/>
        <property type="gene ID" value="VAB18032_03780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03780"/>
    <dbReference type="eggNOG" id="ENOG50321TY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2132461_0_0_11"/>
    <dbReference type="OMA" id="GWEFYAS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12487" checksum="62E32A207708C8B3" modified="2011-06-28" version="1">MNTPRKTRRAVMADILLLADPTEIRTHTDGVALAVSFDRIAELRSWLHLAGLNTPDTLTAEHTGTTDDGRPWQVMYAYPTLHGWEIYAHAKEYTTGGDLDPTTIDRLAALAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3C9</accession>
    <name>F4F3C9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08675"/>
    <dbReference type="EnsemblBacteria" id="AEB42853">
        <property type="protein sequence ID" value="AEB42853"/>
        <property type="gene ID" value="VAB18032_08675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08675"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354448_0_0_11"/>
    <dbReference type="OMA" id="SRANWPL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="775" mass="80232" checksum="A478C4B6E9039C6A" modified="2011-06-28" version="1">MALVRVYCGLASADPADRPASAGSTLTSAVVDDAGRLLHVCEVDDDPAGYARLVTLLVDRSGGPSGAAIAADTDDHTVTSLLSAAGRPLAIADDDSVDDFAERFADDDSVEEMQSPPAVRRAVGLARALQAGALSAVTLPAPRDLAGYKQILAAHAALTSGRHSAAVALREVLRELYPAALRAFPDPAESIPLAVLDALPEPSMLTDAGRGRDAAVTADAVAAQLTADGLGDPDAIDEAVTALRVAISETPRRSTVNRALTSAAAETIRQTVASVRACDAGCEALVGALQARTPGPAQATGRRAAARRGEPVGELPTVNSAAGLRAVRPTGPEPAAGRRSRPEPVSGTTAPPAPRPTNPPPVAPAPVAPPPVAPAPIAPAAVAGPPVSAPPSRPDSAGSRIDGPTNRPISTPPPPPGITPIAPAPRGSIPPAEAGEPFRPTLTTAAINSARAERQRTIIPPRPKTNGAPPTPTGGFSATDLSVPVPTPRPGQEPAAPGSRANWPLVNNPENPADSSARNPVAGAYDDHNRGVGPATGPEVPAELTTERRVTPPWLADDLPPEPPVLRLVEPPPLADRALRNGPESHLENPPLRLVDRAHDEQRGHAAERLDPPLLPRRPAPPVEHRPSPISDEGDGDLLIFAQAKSAWFVGHGEDAALDWSSTADTGWQAAEQAARPAVGAETNAGLPKRVPQANLVPGSPLREERPLRIVRDAASLAENTTGYFRGWRRGQEIGGFAVGGRPGREAAGGWDFSRDTGDRDDDREYEYRSAGYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3E3</accession>
    <name>F4F3E3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731538.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08745"/>
    <dbReference type="EnsemblBacteria" id="AEB42867">
        <property type="protein sequence ID" value="AEB42867"/>
        <property type="gene ID" value="VAB18032_08745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08745"/>
    <dbReference type="eggNOG" id="ENOG50331SS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080168_4_1_11"/>
    <dbReference type="OMA" id="HRYPVAD"/>
    <dbReference type="OrthoDB" id="1857091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="PTHR12704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="224" mass="23655" checksum="A2A9DE69446E3C9F" modified="2011-06-28" version="1">MTGVPLAEELLLLAYDDETGKATMPRISLDLGMAAAALIELSLAGRIAYDDGALTVVDPTPTGEPVIDDVLARIAADTPHSPSSWVQRLRHGLRDRILGDLCEHGVVRDVDETELGFIHVHRYPVLDRSVEADTRQRLTAALTGAPPDERTAALATLVAVLRMESALGLSGEAAEETHHRLEKIASGAGFTGEVSIEGSVVRPSVGLVVAALGRAVQAALGPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3I8</accession>
    <name>F4F3I8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14920"/>
    <dbReference type="EnsemblBacteria" id="AEB44096">
        <property type="protein sequence ID" value="AEB44096"/>
        <property type="gene ID" value="VAB18032_14920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14920"/>
    <dbReference type="eggNOG" id="COG5017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085408_0_0_11"/>
    <dbReference type="OMA" id="VCHGGPA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="89"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="24600" checksum="9D7907815F1832CD" modified="2011-06-28" version="1">MSGEATRTDAQFGASADAAAAHIPAPRDGNRVGRAQLLVAVGTDKHPFDRLVGWLREWYGEVADEVVLTVQHGHTRVEGLPDAVPFLGHAELQTAMAGADLVVCHGGPATILEARRHGHLPIVVPRDPSLGEHVDNHQQLFARRLGAAGLVALCETRQELRDALTAGLAEPGRFTVTVDADAAEAQRTAVRRVGMIVEELVAEAAQRRHRPWWRPWRGPGPNGRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3J4</accession>
    <name>F4F3J4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732769.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14950"/>
    <dbReference type="EnsemblBacteria" id="AEB44102">
        <property type="protein sequence ID" value="AEB44102"/>
        <property type="gene ID" value="VAB18032_14950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14950"/>
    <dbReference type="eggNOG" id="COG4329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118115_0_0_11"/>
    <dbReference type="OMA" id="ILQWHHM"/>
    <dbReference type="OrthoDB" id="1634831at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018719">
        <property type="entry name" value="DUF2243_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10002">
        <property type="entry name" value="DUF2243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="180" mass="20026" checksum="52C863A4FA266571" modified="2011-06-28" version="1">MTERTIDGADIRLPATILGVGLGGFVDGIVLHQVLQWHHLLSNTGADNIGIREYPVDTVAGLQMNTLWDGLFHVVTWVAVLTGLAMLYARVTRSRGRLWRSPMLWGWALLGWGLFNLVEGIIDHHILAIHHVRAGEHQLWWDLGFLALGVVLIAVGWLVQRRATAVDLCADDTTSASRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3J8</accession>
    <name>F4F3J8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ordered locus">VAB18032_14970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732773.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14970"/>
    <dbReference type="EnsemblBacteria" id="AEB44106">
        <property type="protein sequence ID" value="AEB44106"/>
        <property type="gene ID" value="VAB18032_14970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14970"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_2_3_11"/>
    <dbReference type="OMA" id="DRMPVVD"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="13"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="144" mass="16219" checksum="50DC2504CDBA2E0D" modified="2011-06-28" version="1">MAEGPKQQMPARRKARKRALDVLFEADLRDRPPVEVLAGYIERIEKPRPDHLGYAVGLVEGVAGHLDRIDELISSYAEGWTLDRMPVVDRNLARIAVYELLYVDEIDDAVAISEAVELARQMSTDDSPRFLNGLLGRIAEYATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3T3</accession>
    <name>F4F3T3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_21420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21420"/>
    <dbReference type="EnsemblBacteria" id="AEB45384">
        <property type="protein sequence ID" value="AEB45384"/>
        <property type="gene ID" value="VAB18032_21420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21420"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_61_1_11"/>
    <dbReference type="OMA" id="FVGLQTW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="3"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="399" mass="39991" checksum="53802267B5412303" modified="2011-06-28" version="1">MGALIGLSGGTFLYTTAEALPIGLLLPMAADLAVTPPQVGLLVTAYGAVVMIASVPLTALVRTVPRRRLLSTLLAGFVLSTAITVVADDLTLLLAARMATAATHALFWAVVVPAAAELFPPRLRGRVVAVVFAGGTVALALGVPAGTWLGERAGWRASFLAVAALGAAVLATVASLLPSTRPDQGHAARGATPDARRFWLLVAVAVLATAGAIAAYTYVALFVTEVAGFSATSVGAILLVRGIASVLGILAVAAVVDRGPWSVLAATVALQSGALLGLYAFGHRPGVAVALIAVAGLAFAAFTAALGGLVLQVAPGRSDLAAATVSAAVNVGITAGALIGGLALPNHGVRSTVLIGALLGVAAAMLAVGERRLRPVARTEHRRYDEKPSGSAAQSERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3U7</accession>
    <name>F4F3U7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734051.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45398">
        <property type="protein sequence ID" value="AEB45398"/>
        <property type="gene ID" value="VAB18032_21490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21490"/>
    <dbReference type="HOGENOM" id="CLU_2014289_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="123" mass="13705" checksum="4641F087D1D75F7F" modified="2011-06-28" version="1">MNAFDLSPAQIRNRLILRARQAALAATGRQFPWSRGRGQATRTRPPVVPRVTVTAGQVVQLGETDYRYATGALRLRILRVRLDISQWYDGEWVWLEGVEIGPDGKPGAFRPVLARVAALRPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3X2</accession>
    <name>F4F3X2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 1 extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21615"/>
    <dbReference type="EnsemblBacteria" id="AEB45423">
        <property type="protein sequence ID" value="AEB45423"/>
        <property type="gene ID" value="VAB18032_21615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21615"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_2_11"/>
    <dbReference type="OMA" id="AKEGWAN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307653" evidence="1">
        <location>
            <begin position="32"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="458" mass="49133" checksum="1EC8C16096ADD83F" modified="2011-06-28" version="1">MRHEASFRLSRRGLLTSALGVGGALALGACASREGDTGTPSATTGTPTLGASGMQWDRFKGETLNLLLCEHWWTSAVSKRFPEFEALTGMKIKANTLSEDSYYQQALVALSSGATTYDALMVGNLQAGQYMNAGWLEPLDSYFGGSGLVNADWFDTNDFFAPARKASSLNGELMALPLSAEAGVVIYRKDLAAQAGVTAFPTQESLVDASAKLSAAMERPFAGRGRRGLDIVWTWTNFFLTQGGEFYNGNTPTVDSPEAVAATELYVQQLLTKYGPKGASNMSWLEATGSVNEGRAALYTDASGLLSVVLDKNSSKHTDQIAVSRWPDSATAKAAPNYWYWMAGIPKASRKKEQAALFYAWAMSKETATSVSAESGSPSARESVWSNDDFLSFYPGDMSTEIVANLQAVQPDRVPYARPTFPSEADALSLELIKVLVDGKDPKRAMADAAAAMARAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F462</accession>
    <name>F4F462_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Undecaprenyl-phosphate galactose phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_03965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03965"/>
    <dbReference type="EnsemblBacteria" id="AEB47875">
        <property type="protein sequence ID" value="AEB47875"/>
        <property type="gene ID" value="VAB18032_03965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03965"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_3_2_11"/>
    <dbReference type="OMA" id="WHRPYTA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="9">
        <location>
            <begin position="311"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="503" mass="55528" checksum="9DD0C7CF44817F15" modified="2011-06-28" version="1">MRHVDSFEIQPPNPPSHNGVPRSAWARARRRVSRWHRPYTAILLLLDFAAAAFASFTAIRTFDQATAGFHEAQNDPTWFHTVAFLLLPLGWLTILWFNGAYDRRCLGLGPDEFKRVIRAGVAVCAAVSFLAFATKTDLSRFTVGTALLLALLLILLGRILTRFVLHVMRRNTQQAAHRMVLVGTLPECLEVYTAVTRNPAAGLVPVAIHITDGYAAAKGVQTPVPVYAGRDVLALVREVGGDTIAVCGSASAEPGELRRLAWQLEGSGVDLVVAPQLTDIAGPRVHIRPIEGLPLLHVEEPTLSGPALLAKNMMDRVAAGLGLLALIPVFIVIAIAIRISDPGPVFFRQPRVGHEGRTFRVWKFRTMYVDAEDRLASLVDQNETDGMLFKMKQDPRVFPVGRFLRASSLDELPQLINVLMGEMSLVGPRPLPADDGDFLGDVRRRLLVRPGMTGLWQVSGRSDLSWDEAVRLDLYYVDNWSLAYDLSILWRTVGVVLARKGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4A1</accession>
    <name>F4F4A1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736546.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04160"/>
    <dbReference type="EnsemblBacteria" id="AEB47914">
        <property type="protein sequence ID" value="AEB47914"/>
        <property type="gene ID" value="VAB18032_04160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04160"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055597_1_2_11"/>
    <dbReference type="OMA" id="PPWFDCD"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="21768" checksum="FD7CEB1A092A61B2" modified="2011-06-28" version="1">MSAYAAVVLAGGAARRLGGLDKPALPVGGVPMRERVLTAVADASPRILVGPGPAPPGVRLTRESPPGGGPVAATAAGLALLDADVPAVALLAADLPLLTRSAVGELLRHLDTAPAASSSAEPAASSSEPPADGVCFVDADGRRQSLCGVWRPAALRAALDRLTVRRGGLAGAALRELLADLAVRELTWPGEGPAPWFDCDTERDLRQAEEWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4J4</accession>
    <name>F4F4J4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731623.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09170"/>
    <dbReference type="EnsemblBacteria" id="AEB42952">
        <property type="protein sequence ID" value="AEB42952"/>
        <property type="gene ID" value="VAB18032_09170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09170"/>
    <dbReference type="eggNOG" id="ENOG5031I44">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275454_0_0_11"/>
    <dbReference type="OMA" id="VTGCQAL"/>
    <dbReference type="OrthoDB" id="1560333at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307414" evidence="1">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="23414" checksum="135010D1628F097A" modified="2011-06-28" version="1">MPAPSATLRALTASAVMLLTVTGCQALDDAGRAMGRTDIVNDLAARMDRALELTYSAEYQLGGGQTALIAQDPARSAYEWPGGKLTVTAEATARCDTEGKRTVCTLHAPPAADSNPSTVVYAAAEREGLVTPPMVMGLLTAAGLDPGAVITQSGTTVAGLLATCVEVQQAVENFSACVTGEGALGSFTGRVDGEPVELALSRFQEQVDGATFELPQGAGIVDRRRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4L0</accession>
    <name>F4F4L0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15200"/>
    <dbReference type="EnsemblBacteria" id="AEB44152">
        <property type="protein sequence ID" value="AEB44152"/>
        <property type="gene ID" value="VAB18032_15200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15200"/>
    <dbReference type="eggNOG" id="ENOG50347RZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089617_0_0_11"/>
    <dbReference type="OMA" id="HEPHRSH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="222" mass="26082" checksum="D819D3EB6C6A8E0E" modified="2011-06-28" version="1">MPQPLLVPAKGDAFDFNLHVVYLWTATNMTFDGLRLRAEALLPWAMGIVRERAVDLAREHEPHRSHDLERALNDLLMHQRWPQEAHLPQFTVRLRVSPDERVREWLRPYWEQRIALECEHELEKIRTRQADDLTRRWAAVLQNLQDEPVTAYAARLTGAEFAEVFQRYVTERRDIVPKLVELLREAVKGHGDLGLGPSEYTQAWDIALRTYERQQGLTRQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F538</accession>
    <name>F4F538_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28246"/>
    <dbReference type="EnsemblBacteria" id="AEB46720">
        <property type="protein sequence ID" value="AEB46720"/>
        <property type="gene ID" value="VAB18032_28246"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28246"/>
    <dbReference type="eggNOG" id="ENOG5032U4U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104647_0_0_11"/>
    <dbReference type="OMA" id="HGAQHIP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="21811" checksum="16E375BC17A683C2" modified="2011-06-28" version="1">MALRQVFTDLFVVAWVYGTIRCALWLHDLVQRLAVPGQKLEGAGGGLADNLAEAGGKVGRVPLVGDELTAPFERAADAARSLAEAGRDQQELVDQLALALSVGMMIVPLGLVLFGWLPLRVRWMRRAGSAATLAAAPAGQDLLALRALANQPLRRLTRINPDVAQAWRDGDEHTITALATLELRHLGLRTPTPTPPSPATRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F597</accession>
    <name>F4F597_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsF</name>
        <name evidence="9" type="ordered locus">VAB18032_04315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736576.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04315"/>
    <dbReference type="EnsemblBacteria" id="AEB47945">
        <property type="protein sequence ID" value="AEB47945"/>
        <property type="gene ID" value="VAB18032_04315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04315"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_5_3_11"/>
    <dbReference type="OMA" id="ITEASPM"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020815">
        <property type="entry name" value="Ribosomal_S6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01048">
        <property type="entry name" value="RIBOSOMAL_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="96" mass="11026" checksum="D87D63A361745E12" modified="2011-06-28" version="1">MRHYEIMVILDPSLEERTVAPSLDTYLNVIRTAGGSVEKTDVWGRRRLAYEINKKAEGIYAVVDLQATPEAVAELDRQLRLNESVLRTKVIRPEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F598</accession>
    <name>F4F598_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endonuclease IV</fullName>
            <ecNumber evidence="9">3.1.21.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_04320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736577.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04320"/>
    <dbReference type="EnsemblBacteria" id="AEB47946">
        <property type="protein sequence ID" value="AEB47946"/>
        <property type="gene ID" value="VAB18032_04320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04320"/>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_0_2_11"/>
    <dbReference type="OMA" id="HPGSHLK"/>
    <dbReference type="OrthoDB" id="1088517at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="14"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="263" mass="27731" checksum="5535EA2BB9AA68F3" modified="2011-06-28" version="1">MRIGAHVDPTDPLAEAAAREADAVQFFLADPQGWKAPQPRADAEQLRTADVDIYVHAPYVVNVATGNNRIRIPSRKLLLAHAKAAAAIGAKGLIVHGGHVNAGDDPQTGFDNWRKALTYAQEAGGFGLPVLIENTAGGENACARRLDALARLWDAVGDHEVGFCLDTCHAHAGGEELLGLVDRVKAITGRIDLVHANNSKDAFGSGRDRHDNLRGGTIDPELLVTVIRAAGAPAIVETPGGTTGQGDDIAFLRAQLEAETAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5L2</accession>
    <name>F4F5L2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09630"/>
    <dbReference type="EnsemblBacteria" id="AEB43044">
        <property type="protein sequence ID" value="AEB43044"/>
        <property type="gene ID" value="VAB18032_09630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09630"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144751_0_0_11"/>
    <dbReference type="OMA" id="REWNNET"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="15101" checksum="8BAE54E2A3180D90" modified="2011-06-28" version="1">MALTDSVNRDANRALRARFDEVYGQYQQLRSGLDELQTRLAELRVTQRSDDGQVTATVGAQGELIAVDLNPSIYRDHDAKALSAKITATVRRAAAAATTATQDLVSTYLPTRSGAADFLRTGDFGTLLGRADTVLRRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5S3</accession>
    <name>F4F5S3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732950.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15880"/>
    <dbReference type="EnsemblBacteria" id="AEB44286">
        <property type="protein sequence ID" value="AEB44286"/>
        <property type="gene ID" value="VAB18032_15880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15880"/>
    <dbReference type="eggNOG" id="ENOG5031XN0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1146185_0_0_11"/>
    <dbReference type="OMA" id="LRHSDAW"/>
    <dbReference type="OrthoDB" id="1610961at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="27071" checksum="4026517B08D87C7E" modified="2011-06-28" version="1">MFLTDPALRRIAADTHDVLPEPLWRHDTATLNPIGDLARLLHTTARDFTDSTTALDAALLRVDALASRGRRGLAARADIHIAGYQQTLTDALAARERHLVLGAMLVTAYRAWRSHRPVLGSSDERHLLLYRGDPSRGVATLRLKDPGTWLVVPDAEAASAFTIPYPDRVVGEVTETEQGWAPTAYTDPQHRQIQSGMTYPLPVCDDLASACRSLLRWWHLRHSDAWRSRTPAQLTPAELAHLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F623</accession>
    <name>F4F623_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734234.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45582">
        <property type="protein sequence ID" value="AEB45582"/>
        <property type="gene ID" value="VAB18032_22410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22410"/>
    <dbReference type="HOGENOM" id="CLU_1331470_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="206" mass="22173" checksum="05027478DEF81672" modified="2011-06-28" version="1">MGIFRRRRQLPQQPPPDLPYPPPPPTLAPGDLAAARQVVRAFLAGLGDDDRMCTAGTAVVQAGGGVADLDQLMRNVRLIHQTGDLGIDRPWRWLAVVTAEARQLGDLALVADIAHFVHLWDTRLRSRITSGELTMALQTPPQDAVREIYAIVVAALAEVDPDHVVADGTGGITLAALRTGIAHRILDADPPYPAEVSAEARRITPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F643</accession>
    <name>F4F643_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46795">
        <property type="protein sequence ID" value="AEB46795"/>
        <property type="gene ID" value="VAB18032_28621"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28621"/>
    <dbReference type="HOGENOM" id="CLU_3067416_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="53" mass="6098" checksum="414FC3133A18CAF8" modified="2011-06-28" version="1">MPPMLLDGIPLSQMFFALVMWLVGQVVLYIVIRMAVRHAIEDADRRRASEQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F650</accession>
    <name>F4F650_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK domain protein ATP-grasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28656"/>
    <dbReference type="EnsemblBacteria" id="AEB46802">
        <property type="protein sequence ID" value="AEB46802"/>
        <property type="gene ID" value="VAB18032_28656"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28656"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055286_0_1_11"/>
    <dbReference type="OMA" id="CPMTFQE"/>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="134"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="37982" checksum="4460AECC4DF8A311" modified="2011-06-28" version="1">MTTSPSDRGILIFTQDFDPTVDPVVRTLTARGADIVRVDLSYFPQTLTFTTSDFDGERRRLLHRGREVDLDRLSGVWYRRPTAFRFHEQMSEAEQQFARNEALHGIGGILRSTDCLWVNRPDVDAVAELKPYQLQLAKQVGMRVPRTLLTNDPDEVRALVSAADKPVVYKALTGGVIHYPGAFPSGLYTTVVGDEVLTNADRVQHTICMFQEYIEKAYEVRLTVVGNTWFPVVIDSQALPTTSVDWRGENHLPYGPYKPLPDEVVAKTQRLLDHLGLVYAAIDFIVTPDGEYVFLEVNPGGQFMWLQHDLGLPMDETIADLLLAGGPFRRGEVTQVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6H3</accession>
    <name>F4F6H3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10005"/>
    <dbReference type="EnsemblBacteria" id="AEB43119">
        <property type="protein sequence ID" value="AEB43119"/>
        <property type="gene ID" value="VAB18032_10005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10005"/>
    <dbReference type="eggNOG" id="COG4278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107607_3_0_11"/>
    <dbReference type="OMA" id="AGCHDSP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="16748" checksum="2FC28B779A176FA3" modified="2011-06-28" version="1">MLTIDRVGTGRELVSDELFAVLTARIARDHSELAADVPARIMDQALAFLAACAITTEPLGPSDLVDIGWHTFILHTRDYADFCQRIAGRFIHHQPDPPAEETGPSAPEPLGVPISRAVAAIRAAGLAVDQELWVGAADCQSKCNQCHAGCHDSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6I4</accession>
    <name>F4F6I4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732974.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16010"/>
    <dbReference type="EnsemblBacteria" id="AEB44312">
        <property type="protein sequence ID" value="AEB44312"/>
        <property type="gene ID" value="VAB18032_16010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16010"/>
    <dbReference type="eggNOG" id="ENOG5030V5M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137628_0_0_11"/>
    <dbReference type="OrthoDB" id="1649290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="26629" checksum="78282DBBAD964D76" modified="2011-06-28" version="1">MTTHTLTPRPGFERYTIQVGWNPHHTYFATVADFTNNPTTNAEGEPINLQLGLIETILDPSEVLRAVEPYAVIPADLTATLHADRAAHPPRRSLNTPPPPGLPSPAKSGNPAAHPPAGPGLGRTARRRPTASAWFPPIAITGSRLLRAELQAVQRDAGCEFDYAASIPEGRRYATRRPLIIIGTDLVARVRRPLTCRGLVVIASVNPPDTRVWEPTGRVGATYFIVLPTARDWLAHHLLRNLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6L2</accession>
    <name>F4F6L2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N6_Mtase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16170"/>
    <dbReference type="REBASE" id="34490">
        <property type="entry name" value="M.VmaORF16170P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44340">
        <property type="protein sequence ID" value="AEB44340"/>
        <property type="gene ID" value="VAB18032_16170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16170"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022127_0_0_11"/>
    <dbReference type="OMA" id="NERSWGH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="696" mass="74884" checksum="18341B5F8F72D1AD" modified="2011-06-28" version="1">MTRKSTLAPSETTLTASGIARLAKVGRAAVSNWRRRYADFPTPVGGSPASPFFDAREVEDWLRRHGRLHQASTDEWAWRHVESYQPAAQISDVLGIAGALLLVRADQAPATGTGLPTPRQLVAQLRTLDPDLSRMVDALLPKQWTAQLSTLLGTVDQLAAEQGAESAFEYLHNRYVSSAHSMSGLAGTPDTVAEVMLALAESGANTFDFTSGTGSILRIAADKALTRGTATRCYAQEISPQYALITLLRLWLLHLRARRSMDNAEPPVVRVGDSLLADALPDLRADVVVANFPFGIHDWGHDRLAYDPRWTYGLPPRTEPELAWVQHALAHLAPSGTAVVLLPPAAASRPAGRRVRAELIRRGALRAVVALPAGLMPPTAIGLHIWVLTQPDPDQPPPGDILVVDTTTTDRPLTETVRAAWSAYRSHEYAELPGVHRTVPVIDILDDQVDLTPQRHLPHANDPATDPAQIIAKIGEFDHLLDHLRRGLPAVQPAPDGPLRGAPQADVADLIRSGSITVHRAPTRSRSTGVTVTGIVLTAADVISGGPATGTATRTAGDDPGPEVRHGDILVPVIGRRISAWVATPEQVSAELGPGIQLIRIDTTRFDPWFIAGVISRSDNRRIAGRASSTGNGAIRIDVRRLSIPVVALEQQHAYGHAFRQLIEFRTTLERASATGVTLAREISDALTSGTLGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6P6</accession>
    <name>F4F6P6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733034.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16340"/>
    <dbReference type="EnsemblBacteria" id="AEB44374">
        <property type="protein sequence ID" value="AEB44374"/>
        <property type="gene ID" value="VAB18032_16340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16340"/>
    <dbReference type="eggNOG" id="COG4521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_3_1_11"/>
    <dbReference type="OMA" id="FIWDPVL"/>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010068">
        <property type="entry name" value="Peri-bd_TauA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF38">
        <property type="entry name" value="PTHR30024:SF38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307452" evidence="1">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="115"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="35464" checksum="DD117748EF3E29EA" modified="2011-06-28" version="1">MRKTLGLLAAVSLLLSACGDGAASGGDPGRKTIRIAYQAFPSGDLIVKNQRLLENALPDYQITWTKFDSGASINTAFVAGSVDIAAIGSSPVARGLSAPLNIPYQVAFVLDVAGDNEALVARNGAGVTDITGLRGKKVGTPFASTAHYSLLAALDRAGVKESELTIVDLEPQDIQAAWTRGDLDAAYSWLPSLDELRKTGTVLITSRELATAGKPTLDLGVVATDFVEAHPAAVDAWRKAQSQALNLIHDDPAAAAKSVGAELNLSPEEAQRQLSQGVFLKPEDLASPEWLGTSAAKGKLADNLVSAAQFLKDQQKIDAVPDLATVQAAIYTVGLPDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6R3</accession>
    <name>F4F6R3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_22440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734240.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22440"/>
    <dbReference type="EnsemblBacteria" id="AEB45588">
        <property type="protein sequence ID" value="AEB45588"/>
        <property type="gene ID" value="VAB18032_22440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22440"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="OMA" id="LMMSARG"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="25194" checksum="91BCCF0115174AE9" modified="2011-06-28" version="1">MTAVLVIEDDDRIRLALLLALEDEGYEAHGAATAEEGLRAQRRSPADYVLVDLMLPGIDGFECIRQLRRDDDVPIVVVSARDDTHDIVAALEAGADDYVVKPVAIKELTARLRALRRRARTVTPVEEPVPVLVFGELEVSPEAGEVRRAGAPVAVTRTEFRLLCELAEHAGRVLSRQQLLSRVWGYDSGDERLVDVHVGRLRQKIEADPANPKHLVTLRGLGYKLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Z4</accession>
    <name>F4F6Z4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46858">
        <property type="protein sequence ID" value="AEB46858"/>
        <property type="gene ID" value="VAB18032_28936"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28936"/>
    <dbReference type="eggNOG" id="ENOG5033VW7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1049487_0_0_11"/>
    <dbReference type="OMA" id="ERNGPND"/>
    <dbReference type="OrthoDB" id="1984042at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="265" mass="29354" checksum="9A7051388CA8B138" modified="2011-06-28" version="1">MVLRRFLYLNNTSVDSYLGVLEGGLSDERTRRTGERGIRGGDAGLSFSPVSGKISGQRERSEEDERVVRDTPELRFDRLMTALEAEPERWNYERVLESDGLFERSAIGTLISVDCEVEVPQMSLLLAQPEQLGEMLDMIEIFGPMASAFGANTSGMPDPEKIKAARGFTKMKADMIVVGDIDEGAPRLAGKLERQHVRDIPDGEATVVGKVARRWKQGEHYSLMALPGAALMSRAQRRKAQPVDPDDENVLHGPALTLDILAIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Z9</accession>
    <name>F4F6Z9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28961"/>
    <dbReference type="EnsemblBacteria" id="AEB46863">
        <property type="protein sequence ID" value="AEB46863"/>
        <property type="gene ID" value="VAB18032_28961"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28961"/>
    <dbReference type="eggNOG" id="ENOG502ZKC5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198022_0_0_11"/>
    <dbReference type="OMA" id="PDANTHG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7479" checksum="63278DF83E91C9FB" modified="2011-06-28" version="1">MSRRFPIPRPADDSRFTFGLALDVAQVLAAHGYPLMAEPYDGCGADLLALQQALFSLIYGTDASEVHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F743</accession>
    <name>F4F743_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29181"/>
    <dbReference type="EnsemblBacteria" id="AEB46907">
        <property type="protein sequence ID" value="AEB46907"/>
        <property type="gene ID" value="VAB18032_29181"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29181"/>
    <dbReference type="eggNOG" id="ENOG5032Y7X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2426172_0_0_11"/>
    <dbReference type="OMA" id="ELETEYM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046156">
        <property type="entry name" value="DUF6158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19655">
        <property type="entry name" value="DUF6158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="91" mass="10348" checksum="B222FC3D1385EDAC" modified="2011-06-28" version="1">MSPEQRIPEWGDDRVAAPILDADLPGIDPAELAEEDLIREMESLHRTRLDTLRHATDSALATHLRRTAELETEYLARHPGREVDPSRLRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7M1</accession>
    <name>F4F7M1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16780"/>
    <dbReference type="EnsemblBacteria" id="AEB44460">
        <property type="protein sequence ID" value="AEB44460"/>
        <property type="gene ID" value="VAB18032_16780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16780"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1785325_0_0_11"/>
    <dbReference type="OMA" id="YCIASST"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_7" evidence="1">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="18240" checksum="8B52C85FC28B287F" modified="2011-06-28" version="1">MFDAIVIDSWAENDVADVPPTGDLTAGLTVLGRRYATLVSQPEMTDLLRIVIAELPRFPELAKAHFSQGKLPYFETIRIYLVAEHDAGAADIADPEMAATQFLGMISNYLFWPSLLLPDWTVSPARTTAVVEEAVRTMVARYGTDGHHRDREVFTASTADDTQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7P6</accession>
    <name>F4F7P6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45683">
        <property type="protein sequence ID" value="AEB45683"/>
        <property type="gene ID" value="VAB18032_22915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22915"/>
    <dbReference type="HOGENOM" id="CLU_1460720_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309147" evidence="1">
        <location>
            <begin position="30"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="19425" checksum="AE13D356B3DE9D98" modified="2011-06-28" version="1">MALTAVAGVVLPVLLLAGCASDGAPDATASSDAIRAVPEDLCDRVDYALATSAFDGGPMPIPPADDDRGPNFRCHKGFFEGDEFRGGFVFLKVQSFGGAGEARTGFERSVTVTSAEPFEGGSEIVADAVRYQQLRDDVRIEILDANVIMEVRLAVVSAVSDEQAAAMRPTAVRLAVHALDLIRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7S2</accession>
    <name>F4F7S2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23045"/>
    <dbReference type="EnsemblBacteria" id="AEB45709">
        <property type="protein sequence ID" value="AEB45709"/>
        <property type="gene ID" value="VAB18032_23045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23045"/>
    <dbReference type="HOGENOM" id="CLU_3049165_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="54" mass="5699" checksum="8E84D2FC3F98E8B4" modified="2011-06-28" version="1">MTEPEEIRDDDRADPIVAPPTANPARVQVPAEGPDGRIDKGHPETPGLPSAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7U3</accession>
    <name>F4F7U3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2231 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23150"/>
    <dbReference type="EnsemblBacteria" id="AEB45730">
        <property type="protein sequence ID" value="AEB45730"/>
        <property type="gene ID" value="VAB18032_23150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23150"/>
    <dbReference type="eggNOG" id="COG4244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107155_1_0_11"/>
    <dbReference type="OMA" id="QPLLLMF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019251">
        <property type="entry name" value="DUF2231_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09990">
        <property type="entry name" value="DUF2231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2231" evidence="2">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="184" mass="19310" checksum="50C3215A5BC6F7E5" modified="2011-06-28" version="1">MQSRLRVQGHPIQPMLVTFPYGLFVCATIFDFAQVVGGPALFGEVGYWTVVAALVAAGLTTMAGMVDLWDVPPDRTRRTAISFNLVNAGMAGLFLLSCLVRADAPNRGATAVLLVVELLALAVGGLGVALGARLMRHYEPGRAEPTSFDALRGTGTPRSAVAPRGAAVLGGVDARTVEIVRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7U9</accession>
    <name>F4F7U9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_23180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734388.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23180"/>
    <dbReference type="EnsemblBacteria" id="AEB45736">
        <property type="protein sequence ID" value="AEB45736"/>
        <property type="gene ID" value="VAB18032_23180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23180"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_5_11"/>
    <dbReference type="OMA" id="FRDRTWG"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="292" mass="32097" checksum="D887010D217D7F11" modified="2011-06-28" version="1">MFGQTTTTTPPSTDRGLEDLDAAALAYAARIAGMPPERRHEARDDLVRFALPFAGRLARRYRGRGEPLEDLEQVARLGLVNAVDRYDPERGSFTAYAAITIVGEIKRHFRDRTWGVHVPRRLRDLILEVGQATAALTSELSRAPTVAELSKRLDTPEEEILAALESAAGYSPASLNAPVGGESSAEFGDLVGESDIALESVDDRVTVSGLLHRLPWRERRILAMRFYGNQTQAEIAARFGISQMHVSRLLSRALTWLRQAMLADAPPPWQNGVAESESTTANQTRPASARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F823</accession>
    <name>F4F823_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_29636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735646.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29636"/>
    <dbReference type="EnsemblBacteria" id="AEB46998">
        <property type="protein sequence ID" value="AEB46998"/>
        <property type="gene ID" value="VAB18032_29636"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29636"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_6_11"/>
    <dbReference type="OMA" id="HNGVDWK"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312770" description="Peptidoglycan glycosyltransferase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="70"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="362"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="703" mass="75525" checksum="5A1F2C8D13E34592" modified="2011-06-28" version="1">MTRALLPKVFTVLLAGALAGLALAVAALPAALVYGIGLSALSAPYADLPNTLRTPPTAQRSNLYANDGTTLITSFYQEDRVDVPLDEVAPVMRQAIIAAEDARFHEHSGVDLRGILRAFTVNRRDGTTRQGASTLTMQYVRNVLSNDPRLSEAQRAAATEVSTARKIQEIRYALALERELTKDQILTRYLNIAYFGAGAYGIAAASKRYFSVSPAELTLAQAALLAGLVRSPHTDDPIHGDADSATARRGYVLDRLVESGQVPPDVAQRAQAEPLNLRPSETPNDCTAVPEGHNDWGFFCDWFTRWWNDQRAFGSTVDERQRTLRRGGFTIVSTLDPAVQRSTTEQVRRVYSAQARYAMPTAVVQPGSGRVLALSVNRTYSVAANPSGQKNHPNTVNQLVAGGGTIVGYQGGSTFKLFTLLAALEAGLPLNTVFDAPDRILTRYQISGETSCGGYWCPENASAAMSGEHDMWTAFGQSVNTYFAWLTEQVGADRVVEMAERLGIVLRAQDDAQLARHGARDWGPFTLGVAATTPLDLAGAYATVAAEGIWCAPTPITLITDATGRRVGAGQPDCRQVLDVDVSRAAVDAARCPVGDQSMYHTCDGGTATRLRGQLNRPVGGKTGSSERYATETVVAFTPQLAVAAMAANPDDPQDAVGHAVQRAMVDSVGEILAFALRDQPVRDFVPPSDTTAWRVTGERTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F897</accession>
    <name>F4F897_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10700"/>
    <dbReference type="EnsemblBacteria" id="AEB43258">
        <property type="protein sequence ID" value="AEB43258"/>
        <property type="gene ID" value="VAB18032_10700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10700"/>
    <dbReference type="HOGENOM" id="CLU_2002933_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="12957" checksum="5750A5F6CB875C84" modified="2011-06-28" version="1">MWGSRRAVGWVTVYVLAGAVLLAIGVIFLVDEGLERASWWAGLGAFVITVVSAAIAVTRTRQQTPVDPKPAPPAEPDAPLRTDESDVPLPQTGTIEQHNTGGINIANTGTIGEVDVRADGGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8B4</accession>
    <name>F4F8B4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10785"/>
    <dbReference type="EnsemblBacteria" id="AEB43275">
        <property type="protein sequence ID" value="AEB43275"/>
        <property type="gene ID" value="VAB18032_10785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10785"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_3_11"/>
    <dbReference type="OMA" id="VYASFWQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="59"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="27841" checksum="C4F3D8748EB0E995" modified="2011-06-28" version="1">MRKALLGLTGLAGFLVVWQLIPTLGLINSQYLPYVTDVFARLAEESVDLAFWRRLGSTMKSWAIGLTVATFAAVVLGTVVGLVPFLRRATHTMIEFLRPIPSVALIPLAVLMFGIQMQAALVIIIYASFWQVFVQVIYGVADVDAVARDTARSFGLTRREQLTHLVLPTALPYLMTGVRLAAAVALILAITAEMVIGNPGLGRMIELSRSAGDSVGLYAFVVVTGLLGLAVNLVFRFVERRTLSWHESIRGEQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8J5</accession>
    <name>F4F8J5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="2">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733195.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17180"/>
    <dbReference type="EnsemblBacteria" id="AEB44540">
        <property type="protein sequence ID" value="AEB44540"/>
        <property type="gene ID" value="VAB18032_17180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17180"/>
    <dbReference type="eggNOG" id="COG3867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011259_2_1_11"/>
    <dbReference type="OMA" id="GVNTVRQ"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="PTHR34983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005129465" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="367" mass="40109" checksum="1F3EFC9657978754" modified="2011-06-28" version="1">MKPSLRAVLAVVVLAAPLALTAPAQAANTLTMRGADVSSLQRSLDLGARYYNASGAQADPYDILSAKGVNYLRLRIWNNPISGYNNKAKVLQQARTIKAKGFKLLIDFHYSDTWADPGKQYPPAAWANHSLSQLQNDVYTYTHDVCTALKAQGTTPDAVQIGNEINVGMLWPAGQVVNNNFAPLASLLKQGYHATKACNSGTQVWIHTANADSTANARWFYDGIRAQGVTWDVTALSYYCMWHGSLANLYNVIADVKSRYGKPVVLAETAYQFTTANADHQGNAIPGTVLCDNIPATWAGQAQQFSWVQNTVRNAGGVGVFYWEPTWYAIRGNGWDPADINGTGNGWDNMAIFNWTGHVNPHVVWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8W3</accession>
    <name>F4F8W3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29861"/>
    <dbReference type="EnsemblBacteria" id="AEB47043">
        <property type="protein sequence ID" value="AEB47043"/>
        <property type="gene ID" value="VAB18032_29861"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29861"/>
    <dbReference type="eggNOG" id="COG1834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057463_0_0_11"/>
    <dbReference type="OMA" id="GTGFRTT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="30006" checksum="DB9215B70EF4F8E1" modified="2011-06-28" version="1">MDATRQHFLMCRPTYFAVDYAINPWMDPTAPVDTDLAVRQWERLRQVYRDLGHTVEEVTPVPGLPDMVFAANGGTVIDGKAMAVQFRDPQRADEAPAYRAWFEQAGFEMYDPKHVNEGEGDILLAGDHLLAGTGFRTAHASHAQLQEVFGYPVITMQLVDPRFYHLDTALTVLDERTVAYLPEAFSPGSQAVLRRLFPDAVHATMADAEVLGLNAVSDGRHVVLPEQATDLAAKLRERGYQTIGVDLSELRKAGGGPKCCTLRLRQGKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Y4</accession>
    <name>F4F8Y4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735712.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29966"/>
    <dbReference type="EnsemblBacteria" id="AEB47064">
        <property type="protein sequence ID" value="AEB47064"/>
        <property type="gene ID" value="VAB18032_29966"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29966"/>
    <dbReference type="eggNOG" id="ENOG5032Z20">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186972_1_0_11"/>
    <dbReference type="OMA" id="IDRLATW"/>
    <dbReference type="OrthoDB" id="2052863at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046086">
        <property type="entry name" value="DUF6104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19599">
        <property type="entry name" value="DUF6104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="59" mass="7164" checksum="7992EE65BCA4ED73" modified="2011-06-28" version="1">MYFTDRGIEELVERRGEEQVSLEWLGERLRDFVDLNPEFETPIERFATWLARLDDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F988</accession>
    <name>F4F988_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731953.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10820"/>
    <dbReference type="EnsemblBacteria" id="AEB43282">
        <property type="protein sequence ID" value="AEB43282"/>
        <property type="gene ID" value="VAB18032_10820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10820"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OMA" id="GMVRTWA"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="309" mass="31979" checksum="33B3C28034CC4857" modified="2011-06-28" version="1">MSPLDGKVAIVTGSGRGLGLAYAKELARRGASVVVNDVDAGVTADAVAAIQASGGRAVAVTAPVGPTETAKQLVTAAVEEFGRLDILVTNAGVLRDTVLWKMSDDDFDTVINVHLRGTFTTVREAVLHMRQAGEGGRIICIGSPTGQRGTFGQTNYAAAKAGIVGMVRTWALELKRAGITANTVVPVAATAMTATVPYFAAAVQAEANGEPMPAFFRHDLGFGTADDVAGLIAFLGSDAAAGVTGQVIGVGGDRLQIWTHPEAALTAYHEGGWSYEALVQAWPTEFAAALQSVGERFPELPEEFQPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9E5</accession>
    <name>F4F9E5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="11">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="11">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">gatB</name>
        <name evidence="13" type="ordered locus">VAB18032_11105</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732010.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11105"/>
    <dbReference type="EnsemblBacteria" id="AEB43339">
        <property type="protein sequence ID" value="AEB43339"/>
        <property type="gene ID" value="VAB18032_11105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11105"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_11"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="12">
        <location>
            <begin position="348"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB43339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="497" mass="53481" checksum="5BEF315A31D09F90" modified="2011-06-28" version="1">MTTTLPAYDEVVARFEPVIGLETHVELGTNTKMWCGCPTDFGGEPNTRVCPVCLGLPGSLPVANKAAIEATIRIGLALNCSIAQWCRFARKNYFYPDMPKNFQISQYDEPLCFDGYLDVEVNGELVRIGIERVHLEEDTGKTLHVGGATGRIHGATESLVDYNRAGIPLVEIVTKPIPGTGALAPEVARAYVTELRDVIRSLGVSDVRMEEGSLRCDVNTSLNRPGEEWGTRTETKNVNSLRSVERAVRSEMLRQASVLEAGGRITQETRHFHEDTGDTTPGRSKETATDYRYFPEPDLVPIAPDPAWVAELKAALPELPRLHRRRLQEAWGLSDADMQSVLNAGAVELIEQTVAAGASPAAARKWWLGELSRRANETGVELADIGATPAQVAELQSLVDAGKLNDKLARTVLEGVVAGEGSPTEIMTARGLEVVSDTGALTAAVDEAIAANPDIADKIRSGKVAAAGALVGAVMKTTRGQADAKTVRELILSRLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9L0</accession>
    <name>F4F9L0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter ATP-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733243.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17430"/>
    <dbReference type="EnsemblBacteria" id="AEB44588">
        <property type="protein sequence ID" value="AEB44588"/>
        <property type="gene ID" value="VAB18032_17430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17430"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="KQAMPGA"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="358" mass="38418" checksum="64A290DED86A4A90" modified="2011-06-28" version="1">MGTVAAHGLCKSFGKVQALNGVSLDVPDGAFFVVLGPSGAGKTTTLRAIAGLEKLDAGSVHLDGADATGDAPAERDLAMVFQSYALYPRHTVYENIASPLRARRSSSSEIAAAVEQMSRLLHIERLLQRRPAQLSGGEMQRVALARALVRSPRAFLMDEPLTNLDLKLRVEMRTELTRIHRSLGATFIYVTNDQVEALSMADQVAVLKEGTVQQVGTPTEVYERPANQWVAGFVGSPPISLLACHAEGDRLVGAQGWTLPRPRWSTAQDGQPLLLGLRAEDLSVEQRGDASLPGELYGLEPLGDRTVVDVQVGTTIVKVKARPTVTGTPGERLQVTVDLDRAHLFDADTGLSVSEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9P2</accession>
    <name>F4F9P2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733275.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17590"/>
    <dbReference type="EnsemblBacteria" id="AEB44620">
        <property type="protein sequence ID" value="AEB44620"/>
        <property type="gene ID" value="VAB18032_17590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17590"/>
    <dbReference type="eggNOG" id="ENOG502Z7KB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701917_0_0_11"/>
    <dbReference type="OMA" id="HLAMEGF"/>
    <dbReference type="OrthoDB" id="471493at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="397" mass="44123" checksum="583A6663F446D5BC" modified="2011-06-28" version="1">MTTVIEGIDLTGLTPGPAQTWGAIRLVPLLRRDPVTDLRLHARLHDPDALSIVQTAPRTAYISFIPHAFVATWTTDSTPAAAYGTQLRDSADTDVPEGIRLVFRRRMARREDRQRLRFLPLHLAMEGYLALQFGGPPIAWQEWTRQAVTRGLSPRVEAGYTGAAIAGLDDALRVFEIHPDQCGMVLYVADALTAAFVVPHPDDYRALHPTLLQDFYGDLLFHYAHLYPAAPDFTVRLDDTAITSVADLRAQLARMDAEWQDFHALLAGGLLAAGRLTVTPAHRMGRFTLARFLPAFDPDADNHIGEVITDETGRLAYLKTFRLSAAQTRRGHLLSQLAAHDWNLDSTATALRTDRDGLVQRLDRAGFGHLLRPDVIDACRRRARQSRGALTAGDRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA41</accession>
    <name>F4FA41_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735797.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00340"/>
    <dbReference type="EnsemblBacteria" id="AEB47152">
        <property type="protein sequence ID" value="AEB47152"/>
        <property type="gene ID" value="VAB18032_00340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00340"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_11"/>
    <dbReference type="OMA" id="IRVGHAS"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="234"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="478" mass="51081" checksum="1AA07750AFD56DE1" modified="2011-06-28" version="1">MSEFDAASAAVQAALDAGARYADARVMHRRYESMSARNGEIEALTQDESVGLGVRALVGASWGFHAVPELSDRAARDAGHRAARTAAASGLVPGPRVDLVAGTPATASWSSPCTVDPLGVSLATKGDLLVAATTTMADHGADLAEGLYQVWDTTKWFVSSEGHRIDQHIRECGGGISATSIGDDETQRRSWPSYRGQYGTTGWELVDSLDLTAHAARIAEESRELLTAPLCPAGETDLILGGEQLALQIHESVGHAIELDRILGWEAAFAGTSWLDLTQLGSLQYGSELMNITIDPTIPGALGSFGYDDEGSPAVRRDAVRAGRWVGVLAGRDSAAVAGLDYGGSVRADGWARLPMVRMTNVGLEPGPHTLDEIIAATDEGVLMDINRSWSIDDKRLNFQFGCEIGWEIRNGRRGRMLRNPTYTGIGPRFWRSMDMLSSEIVPWGTPNCGKGQPGQIGHTGHPAAPARFRNVRVGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAB4</accession>
    <name>F4FAB4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730849.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05245"/>
    <dbReference type="EnsemblBacteria" id="AEB42175">
        <property type="protein sequence ID" value="AEB42175"/>
        <property type="gene ID" value="VAB18032_05245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05245"/>
    <dbReference type="eggNOG" id="ENOG50315GV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086035_1_1_11"/>
    <dbReference type="OMA" id="GEFFWVA"/>
    <dbReference type="OrthoDB" id="2059359at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="210" mass="21697" checksum="76A15C8907FF9AC1" modified="2011-06-28" version="1">MTGFLGAALSFPTVLFSFLLVVVVGYWLLVLTGVLDLGDDLDVDGGAGTFLAGLGLGGVPSAIIFSLLVAVAWFVSLAGTALLDGLGFGSGTRVLVSIGVLLAAAFCAWLVTRLVAIPLGRLFPAESDATRHAFVGRLCVVRTGTVTADFGQAEVTAPDGSSAVVQVRQPGEEKMPAGSSALIYDYDTEGEFFWVMPAGPAFDPLRHSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAR7</accession>
    <name>F4FAR7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733337.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17900"/>
    <dbReference type="EnsemblBacteria" id="AEB44682">
        <property type="protein sequence ID" value="AEB44682"/>
        <property type="gene ID" value="VAB18032_17900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17900"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005857_0_0_11"/>
    <dbReference type="OMA" id="RHEFANG"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1118" mass="122688" checksum="C0BAB26CE328E8B2" modified="2011-06-28" version="1">MWSPGDVLLGAYEVREVIDTGGMGLVYRVWHRQWGMELAVKTPRQELVTSPDDMRRFEAEAQAWVGLGVHPQVVSCAYVRRIDGIPRVFAEWVDGGSLAQAVGDRSLYRGGHRRAVRRILDVAIQCAWGLGYAHRRGLVHQDVKPANVMLDRNDTAKITDFGLATVRPPRPGPEALTTVNGMTLEYCSPEQARGERLGPATDVWSWAVSVFEMFAGRPPTLFGYAAAGALARFVDTGAADPTIPALPPSVADLLRRCFAEDAAERPSGFDVIADELAAIYLDTVFTPYPRQPPDEAPLLADALSNRALSLSDLGHADDVDHLWEEALRIDPHHPHATYNRGLRRWRSGQQTDRELIMQLDAARLSQKDDRIVDHLLALVHIERADKDAAVRLLRDLPDGPDVAAARTAADAVPHRPVPAGPSPVYLDQQHPFALSADGRLAAVTFRDRQLRVWSLQTGRIRHELTGHTGAVTSVSLSADGRVLVSADDTGQVRVWDTTSGGCTRRVDVPPTVAGSVAVSPDGTVVVAVGQDRVVRLLGDPIHVVGRATVAPADSSMSRHGTTVAVTPDNHRVVVFDEWSWHLQVLDVDTGELLWSVGGLRWHGTVSANARFALSATDDGRMWLLDLTAFQITDLGSAALWNNGFSWLAVSDDGRTAVNAFERVVQVWRLDQVRCVFTTPIESRDPMHVALDAHGRVALVELGRGAAERTTSVVHVPEPGPAAPWSYARPQPADRLVGDALVAEENLDLADDLLDTGRLTEARRHLDIVRRMPAYRRHPRLRALWRRVGAFSERTAFTGVWPTRRFEQESRGHWAVTRNLRHAFLESFHQGVRVLDLRTGEVSDSRDGRDTSVEKVTACADDRHVLVTRDDQAETLWDLRTARRVGVVVRDDSGDPTLEVPNPTFEFVRRDGISVLANRVTGQRVYGWSAYPDERVALCGDVVLRVEDDGRTRVLDADLNTVRRTLLPAGGLVQVRRVHPGDAVEVTAEGPLVASADGRVIAATRHEFANGGEVALCVAGRPDTVLKAADAAVVSMALTADGDLLLVASRRQIRLWHLPTGALVTEVECSRDVMAVEMASDGSGFLAVLGYFHVQLWELDWDHRMRTGITGPGHHAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAW3</accession>
    <name>F4FAW3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24140"/>
    <dbReference type="EnsemblBacteria" id="AEB45926">
        <property type="protein sequence ID" value="AEB45926"/>
        <property type="gene ID" value="VAB18032_24140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24140"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031076_0_3_11"/>
    <dbReference type="OMA" id="HDPRILW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="Royal_jelly/protein_yellow"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PTHR10009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="368" mass="40516" checksum="D3CC4B7C679A3C60" modified="2011-06-28" version="1">MRTGLPTDEPVGTLEVVHRFRGPMPTGVTVSHRGRIFVNFPRWGDEVPATVVELRHNREVPYPDLRWNSPAGNDDASAFVSVQSVVVDPVDRLWVLDTGSPMFQPTVPGGPKLVRIDLGTNTVAQVITFPPDVALPTSYLNDVRFDLRRGTAGIAYITDSADGAPNAIIVVDLASGTSWRRLNDHPSTKAESLVNFRPVVEGRPFLVRPPEGPPQPVGVGADGIAISADGARLYYCALASRRWFSVATDALVDRSADEDEVAATVRDEGDKGGGADGLESDDAGRLYLTNYEHNAILRRRPDGEYETVVHDPRLLWPDTLSVAKDRHLYVIANQVHRQPPFNRGRDLRRKPYALFRTRIDAGPVLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAY3</accession>
    <name>F4FAY3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_24240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734598.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24240"/>
    <dbReference type="EnsemblBacteria" id="AEB45946">
        <property type="protein sequence ID" value="AEB45946"/>
        <property type="gene ID" value="VAB18032_24240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24240"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_1_11"/>
    <dbReference type="OMA" id="RYLLEMD"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="128"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="21099" checksum="1A1B23BF053F2E57" modified="2011-06-28" version="1">MPSEVALDDREFVTRAQAGDLEAYELLVARHTASAYRTAVLLGAGTEAEDVIQEAFVKGYRKLSHYRGDSSFRSWLLAIVANETRNLHRSRERRTGLVLRAAQVAPGSEAGEDGAIGAVLAEERRSTLVRALRQLPERDREVIVCRYFLDLSEDETVAMLGWARGTVKSRTSRALAKLRGLLDVEELSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAY4</accession>
    <name>F4FAY4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734599.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24245"/>
    <dbReference type="EnsemblBacteria" id="AEB45947">
        <property type="protein sequence ID" value="AEB45947"/>
        <property type="gene ID" value="VAB18032_24245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24245"/>
    <dbReference type="eggNOG" id="ENOG5032X2Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092084_0_0_11"/>
    <dbReference type="OMA" id="GPTLLWT"/>
    <dbReference type="OrthoDB" id="1915094at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="28648" checksum="923ED2F5BDC9FD7A" modified="2011-06-28" version="1">MADLERELRELSAWLDTPDPPDVTAQVRARLTAQHTATSAPRFRIGTPRLWAAVPRLWAVGRRRRWRYAVVAALVALLVAVLPPGRAALADAVTGLLRFAGITISTSPDPVLPTASPSPLPAQHPAELTQAQQAVRFPIRLPATLEPPERVLVADPDDTGAHRVVTVLWRSGAVRLDAFDGKLNPVFFKQAGGAGAEWTFVDGRQAVWIDAPHPVSYVDRSGVVREESARLAAATLIWEQDGVTYRLEGEFTLAEAVEVAQSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBE2</accession>
    <name>F4FBE2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730911.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05560"/>
    <dbReference type="EnsemblBacteria" id="AEB42238">
        <property type="protein sequence ID" value="AEB42238"/>
        <property type="gene ID" value="VAB18032_05560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05560"/>
    <dbReference type="eggNOG" id="COG1261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078491_1_0_11"/>
    <dbReference type="OMA" id="PEAEANW"/>
    <dbReference type="OrthoDB" id="1887172at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="22173" checksum="E25256E58F788E3F" modified="2011-06-28" version="1">MSVATRNGPSPVDAPVAPPKVVRQRRVRPGLLGLAVLLIALGGLGSAFAVTSVRATGSYLAVARTVEVGSVVSASDLVSVQVAGGQGLDPVPAGRLADVVGMRAAVSLAPGTLLTMAQLTDQPLLGPGQQQIALGLRTAQVPAPKLRPGDQVLLVSTPRDDSSSGSSSGVTRFTATVTDAVSTDGRDEVVVYLALAVRDVPAVVAMAAQDRIAVVLTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBT2</accession>
    <name>F4FBT2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733387.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18150"/>
    <dbReference type="EnsemblBacteria" id="AEB44732">
        <property type="protein sequence ID" value="AEB44732"/>
        <property type="gene ID" value="VAB18032_18150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18150"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_0_1_11"/>
    <dbReference type="OMA" id="WFHGRLI"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="29178" checksum="E1640E5673199272" modified="2011-06-28" version="1">MLHYRLLGPLEVDVDGTNRTPTAPKVRQVLALLLLSPDRVVSIESFIEEVWDAGPPASAVTTTQTYMYQLRKILHGVRREPVLLTRAPGYLLRMQNAQTDLDAFDRFAAQGRALFAANELERAAERLRQALALWRGPVAMPDVTRGPLLRAHLAALEERRIRVLHERIQVDLTLGRYADLVVELRRLAAERPLDEWLHCRLMAALHGLGRRGEALSAYQRARNVLQEQLGLDPSAELRRMQRLVLAGLPLDTASAPSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC39</accession>
    <name>F4FC39_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24695"/>
    <dbReference type="EnsemblBacteria" id="AEB46037">
        <property type="protein sequence ID" value="AEB46037"/>
        <property type="gene ID" value="VAB18032_24695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24695"/>
    <dbReference type="HOGENOM" id="CLU_2978024_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="58" mass="5906" checksum="E56542C928F12F7B" modified="2011-06-28" version="1">MKGITDLELSAEKPATMIAANGNYALVAGKGNIARLRTSPQSTMLSAESAAALMAPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC58</accession>
    <name>F4FC58_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734708.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24790"/>
    <dbReference type="EnsemblBacteria" id="AEB46056">
        <property type="protein sequence ID" value="AEB46056"/>
        <property type="gene ID" value="VAB18032_24790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24790"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_4_11"/>
    <dbReference type="OMA" id="CWEALLW"/>
    <dbReference type="OrthoDB" id="1361074at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="74"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="307" mass="33410" checksum="F281104EC1C6D9F8" modified="2011-06-28" version="1">MTLDPYTAAFLRRMRATHPDLGATVTDPDQARRIQDRARYPRGPQMAQVTNLTADGVPVRIYRPAGPTGPLPVVVYLHGGGWVLCGLDTHDGVCRQLADRAKMLVVSVDYRLAPEHPFPAAPDDAYTATCWVQRRVAQWGGDPDRLAVAGDSAGGALAAATCLRARDLDFPRIAYQLLVYPVTDCLAPRTRDDTHSLLTAEHMRWYVARYLRHPSDGEHPYASPLRAPDLGGLPPALVLLAEHDPLRDEGEAYAVRLAEHGVPVETHLVEGLFHGLFGLGDLVPVGRRAETLAVAGLRAALRGDAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC93</accession>
    <name>F4FC93_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_00940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735916.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00940"/>
    <dbReference type="EnsemblBacteria" id="AEB47272">
        <property type="protein sequence ID" value="AEB47272"/>
        <property type="gene ID" value="VAB18032_00940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00940"/>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_0_1_11"/>
    <dbReference type="OMA" id="DNRHTHG"/>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="6">
        <location>
            <begin position="13"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="26067" checksum="8CF5619CCD3AD5B0" modified="2011-06-28" version="1">MTPTTVLTVAGSDSGGGAGIQADLKVFAALGAYGTSVITAVTAQNTRGVDAVLPLPPQTVTDQLDSVLSDFSVRAVKTGMLGTPAVAGAIADAAAAGRLPQLVVDPVLVATSGHRLGVVAAVERLLPYARVATPNSAEAAALTGAAVTDLAEMTTAARALASGGPEWVIVTGGDVDTGGEALDVLHGPDGTTVLRAPRVPTRHSHGTGCSFSAATAVRLAMGDSVPVAVATAKEYVTRALTGARAWELGAGRGPLDHFGWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCP6</accession>
    <name>F4FCP6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type iii domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_12130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732209.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12130"/>
    <dbReference type="EnsemblBacteria" id="AEB43540">
        <property type="protein sequence ID" value="AEB43540"/>
        <property type="gene ID" value="VAB18032_12130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12130"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001857_0_0_11"/>
    <dbReference type="OMA" id="HDHAWGI"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="926"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1119"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1213" mass="128457" checksum="0A29C6B8ECB7143F" modified="2011-06-28" version="1">MAVFRRLRSTWLDRATRSDQSSSPTVPSARTGPAAVTDVTAVPEAAGTPAPASLDPAAAPRCFGPVPNHAYSPLPVLDSTGAVVTGTGIRKFVDPLPGLGALGRTPLGAELPVAVPDTISHPGCDYYEIGLTEYTQRLHQDLPATRLRGYRQLNLGTDSDGHNTVAPPSRAWHLGPVVLARRGRPVRIKFINQLPAGPAGELFLPVDPTVPAAGEGPLGGPAPYPQNRAVLHLAGAHTGWISAGNPYQWITPAGEITPYPTGVGLTPVPDMPPPGPGATTLYYPNEQSARLLWFHDNTVGLSRLTIYSGQIALFLLTDEAEDRLVADGVLPDEQLPLVFEDKTFVPDDAQLAAQDPTWDRHRWGARGSLWHPHVYQPRQNPYQPDGRNPTGRWDYGPWSRTVPAAGSDAAAVPNPRHDPVTEPDEPPEMPGVPHPSAVPGTYGDTVLVNGAAYPYLEVEPRVYRWRILNACTDRWLNLQLYRAGSDEPMWTPEGQLADADAGEVPMVDAVRAPGRPAGWPTDGRPGGVPDPDAGGPELIRIGNECGLLPAPVVIPNRPVGFRYDRRDPAVLNVDGHALLLAPGERADVLVDFATVAPGSTLILYNDCPAPFPAFDPRYDHHTGAPDRTAEGGAPPSVAGYGPNTRTLLQIRVAGTPATPYDLNRLRERLPTAYAASQHPPIVPDPAYDPCYGTVTAGATRIPVHATRVDFTPAGAAAPAALPLTVKAVRQVFEPEHGRLTGRLGVAHPHAGPRTETVLPLGPTDPATEVLHVSDPAVPVGAPGDGTQLWRVRGTGRQSHPVRFDGLDVQVVGRVGRDGAIRPPYPGELGWKQIVRVDPGEDVILALRPEAPPLPFKIGDSVRLLDPTRPVGEPVGSTPVSPLDGRPASVVNQLVNLGWEYRWCSGAGGHRDQGMSRPLVVRVSPRAPSGLTATAAPGSATALPAINLTWTGNGSRPPATSHLLQRATDATFTSGLTELTVAATATRYTDATVTPGVTYHYRIRAENAVGCSAWSNSIPASVQLTAPTKLSAAIPPAAPLRVALRWANRSFATGIDVQRATNPTFTSGPGTTAIGVGDHHLDPAVAPDTTYYYRVRTTYLGAASPWSTVATVTTPPAPGVPTSVSVATSTPGPDTATVMLSWAASTPASQGAGFTVERALDVAFTRDLATFTVTGRGFTNTGLARGVTYHYRIRSFNVVGTSPFTPPLPITTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCS6</accession>
    <name>F4FCS6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_12280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12280"/>
    <dbReference type="EnsemblBacteria" id="AEB43570">
        <property type="protein sequence ID" value="AEB43570"/>
        <property type="gene ID" value="VAB18032_12280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12280"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_11"/>
    <dbReference type="OMA" id="FHERHAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="196"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="30077" checksum="F2BB2826F2DEC467" modified="2011-06-28" version="1">MRRMTDVRQSSAGVPVIGADPSALQVMAPRVTVGRSFGEFHERHATPVVMLSATVARQLGIHRTGVAVFVADQAHTVVGIFDDVVRRPEAMAAAIVPYSAAERLNQSGGSQPAKRDVLVETSPGAAQLIGRQAPLALRPEAPAELRAIAPPDPRTLRQEIEGSTTRTTLLISGVALLMGTISIGNAATSGVAQRTGEIGLRRAVGARRRHIFGQLVLETTVLGWLGGGVGALLGVLTISIVSVVNGWTPAVEIRSAVFACTASTIAGLLAGLVPAARAARIPPVQALQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCY4</accession>
    <name>F4FCY4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733471.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18570"/>
    <dbReference type="EnsemblBacteria" id="AEB44816">
        <property type="protein sequence ID" value="AEB44816"/>
        <property type="gene ID" value="VAB18032_18570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18570"/>
    <dbReference type="eggNOG" id="ENOG502Z8PQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041274_0_0_11"/>
    <dbReference type="OMA" id="QVDIWVA"/>
    <dbReference type="OrthoDB" id="827116at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="499" mass="53246" checksum="6B8971768E26D82E" modified="2011-06-28" version="1">MSTTAESIKTPTYGNWRRPRKAGLGSLGLVGTVGLFGGLVMVLISSMVSLNTALVVGLPFALMLAPLAIRTADGRNVYNMAAVRIGWLRRKSLGRHLYASGPLSARPGGRFRPPGLLSRVTMLEGRDPYDRPFGVLYHRHRNQYTVVLACEPDGGSLVDPDQVDTWVALWGEWLSRLAHEPGLRGAAVVVETAPDPGTRLATEVLGRISPDAPPAARAVMEEVVASYPAASSEMNTFLTLTYSAPGGARRDHDTMVADLALRLPGVLGGLVAAGGGSAEPLSAERIAEVVRVAYDPAVAAEVLDVRAQHGHTGLEWADAGPAATVETVSHYQHDSGVSRSWLLTLAPRGTVRSGVLRSLLDPALGIRRKRVALVYRPIDPATSAKIVESDRRSAQFMANSTRGLVRARAISEIEAAEQTAAEEASGAGLVEFSMLVTLTVDSVAEIRDAEVTMRNLLGATRIAMRPADRMQAAAFSCALPVGILPWEQTMVPHELKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCZ6</accession>
    <name>F4FCZ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733483.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18630"/>
    <dbReference type="EnsemblBacteria" id="AEB44828">
        <property type="protein sequence ID" value="AEB44828"/>
        <property type="gene ID" value="VAB18032_18630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18630"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OMA" id="MSLHNWP"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="33203" checksum="ECD001279AE6E687" modified="2011-06-28" version="1">MSVTAPSRPPGAATRRRTRPRGRQALLGWLYATPTAVFVALLFAVPLLLVIRMSLSKWSLLRGDQGINAPDNFVKAVDHRFFTESVVFTLKYTALATALLLALGLGLALLVQESSRWNNLLRASFLIPSALGLASASLLFYVLYSPYASPLAPVMDRLGLTFLGSPTAALISTTFLIVWRYAGFYMVLMLVGLQGIPADVYEAARTDGASRWQTFRKVTLPLLRPTLALTTVLCVTGSLLAFEQFYILTKGGPDNSTITVVQLIYMVAFQGQNDLGVAAAISVIVLLALILINALQMRAFRSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDA5</accession>
    <name>F4FDA5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25185"/>
    <dbReference type="EnsemblBacteria" id="AEB46135">
        <property type="protein sequence ID" value="AEB46135"/>
        <property type="gene ID" value="VAB18032_25185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25185"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_1_11"/>
    <dbReference type="OMA" id="PFWANTQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313818" evidence="1">
        <location>
            <begin position="35"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="428" mass="46583" checksum="9D5E0D541179909B" modified="2011-06-28" version="1">MSDPDQGERRRRPRVRVAAAAAALTLVAPMAACASGDDTGVPVINLYYPPEQNLQQVVDRCNTEAAGRYRIVNRVLPREADEQRVQLVRRLAAADDGMDVLGLDVTWTQEFASAKWILEWTGSDRAEVEEGTLEGPLETARYEDKLYGAPKNTNVQLLWYRKDLVPEPPTSWDEMISTAQQLKEQGKPHQVLTMGAQYEGLVVLYNTLVASAGGNLLNEDGTEAVVDEGAVRALEVLRAFATSGVASPSFSNATEDPVRLEFQSGSGAFQVNWPFVYPAMQEANPQLAEQVGWARVPGVDGDTPSRVTIGGVNLAVSRYSTHPEESFEAAKCLRNAENQKFSAINDGVPPTIESVYDDPEMDEAYPMKETILEQLRDPAVRPLTPAYQSISTVSSAILSPPAAIDPQTTAKELRAAIADALESKGVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDD8</accession>
    <name>F4FDD8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proton-translocating NADH-quinone oxidoreductase, chain l</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_01325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735985.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01325"/>
    <dbReference type="EnsemblBacteria" id="AEB47349">
        <property type="protein sequence ID" value="AEB47349"/>
        <property type="gene ID" value="VAB18032_01325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01325"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_3_11"/>
    <dbReference type="OMA" id="MGICSYF"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="149"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="649" mass="66293" checksum="5039AE020F8950A7" modified="2011-06-28" version="1">MSTTTLLGALLPVVPLVAGLVGLLLPPAARGATTDRDTSRRAAIALGVAGAAGALVLAVALLVTLDAPTESSTTWIRFGELTVTLGVRLDGAAALVAVAVAAVALAVQVYSVGYLTRGPHDDTDVDHRYPPYAAQISLFTAAMLLVVVSGDLIMLLVGWEVMGICSYLLIAHDRWLPQAPAAAQKAFLVTRVGDVGFLLGIALLGVSAGSFRIADVLAHDHGTGTLTAAGLLLLAGVAGKSAQFPLHTWLPDAMAGPTPISALIHAATMVAAGVYALTRLWPLFEATPTVLAVLGVMASVTLLLGAFAATAQDDIKRVLAWSTVSQLGYMTGALAVGSPPAALFHLLTHAAFKALLFLAAGVVIHAVGTAAMSRMGGLRHSMPVTFWCTLIGLGALAGVPPLSGFWSKEGVLAAAEGAALHGDGAAPAWVGWLVWLAGLVGVAVTAWYATRLLLRTFFGTTRTPLTHPHDPPALLRWPVLALAVPAALLGLAGFPGWFATQLQRTTPSDAEGVSDLMPPDGLIHLTPTVLLPLALLLLGAGLAGAGWRRDTAADPAAALGPLRPVFARAFRLDDVQHTLVVRPTTALARAARVADERVVDGAVTGTGRGAGALGGGLATLHRSALPRAVVAVLAGALLIALAATLIGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDH3</accession>
    <name>F4FDH3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_01500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736019.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01500"/>
    <dbReference type="EnsemblBacteria" id="AEB47384">
        <property type="protein sequence ID" value="AEB47384"/>
        <property type="gene ID" value="VAB18032_01500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01500"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="YVMGHGQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="27470" checksum="FD517674EB521D44" modified="2011-06-28" version="1">MEPILAVQDLSVRIAGLHILQGVSFTVAPTGVTVLLGRNGVGKTTTLRALVGLTPRNGEVRGTVRMQSATLLGQPTHRLVRGGLGYVPEDRCVFAGLTVAENLRLAERRGSTPAYDRVFALFPELQRRSRQRAGSLSGGQQQMLAIGRVLINDNRLLLVDEPTKGLAPKVVTEVAEVLARVAESVPVLLVEQNLAVVRRLARDAVVLAAGQVAWTGDAQRLLAETELTRSLLGVGSVEGHHAAPGSHHAAPGAGRKDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDU0</accession>
    <name>F4FDU0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732290.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12535"/>
    <dbReference type="EnsemblBacteria" id="AEB43621">
        <property type="protein sequence ID" value="AEB43621"/>
        <property type="gene ID" value="VAB18032_12535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12535"/>
    <dbReference type="eggNOG" id="ENOG5033AAH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120892_2_0_11"/>
    <dbReference type="OMA" id="PSYEEQH"/>
    <dbReference type="OrthoDB" id="1978329at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="118" mass="13412" checksum="70325C5109CC5931" modified="2011-06-28" version="1">MKRQAYRPILITDASRSQDDQLTTRQRRYVMMMCVRAACVVVGAILVGAKAPLLWLWLPLVALGMLIVPWLAVLLANDRPPKDEHRFANRFRRGQPTEAPARSLTAEERPHKVIDAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDX8</accession>
    <name>F4FDX8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732327.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12725"/>
    <dbReference type="EnsemblBacteria" id="AEB43659">
        <property type="protein sequence ID" value="AEB43659"/>
        <property type="gene ID" value="VAB18032_12725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12725"/>
    <dbReference type="eggNOG" id="ENOG50318WM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077385_0_0_11"/>
    <dbReference type="OMA" id="LEMRASW"/>
    <dbReference type="OrthoDB" id="1265024at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021555">
        <property type="entry name" value="DUF3000"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11452">
        <property type="entry name" value="DUF3000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="19926" checksum="439923C37542DEEA" modified="2011-06-28" version="1">MAPPIALPDTFARAVAGLRSATPRPEIGLEEIGAPQRLAPYAFALSASVLRDGDEVTTGRLILLHDPVGHEAWQGTLRLVTYVTAELESDLAADPLLPGVAWTWLTDALDAQEAGYRAIGGTVTQTMSNRFGDLAGPPATADIEIRASWTPTDGDLTSHLYAWCTLLASTAGLPPPGVTALTDRRAAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE24</accession>
    <name>F4FE24_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733548.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18955"/>
    <dbReference type="EnsemblBacteria" id="AEB44893">
        <property type="protein sequence ID" value="AEB44893"/>
        <property type="gene ID" value="VAB18032_18955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18955"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873980_0_0_11"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="8"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="33994" checksum="B482BC9C8333F402" modified="2011-06-28" version="1">MPSMFVADFHTHYACPAYPALPPHQAAPELVRRWHGLARRIADLDGLLAEAGRRGVDLRVLSAPPALVTPHGERTHPDDLRRLNDHLAEAVATAPQRLRGLATVDAFAGDAAAAEAVRAVRELGLSGLVVDCATDGQLLGAAAARPTLTVAAELGVPVFAHPISPAAMTLAFAGLGRFGTSLARGTINAAALLSLLVDGVLAELPGLHVVFPMLGVAGLSLAAATDEGQHITAAAPASQRAHVYLDTMGFVPAAIRFATDLLGADHVLVGGDWPIGARETSRERVETALTQAGLDEAERRLVAGANALRLVDARCVPARNSSSVITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE87</accession>
    <name>F4FE87_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734805.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25275"/>
    <dbReference type="EnsemblBacteria" id="AEB46153">
        <property type="protein sequence ID" value="AEB46153"/>
        <property type="gene ID" value="VAB18032_25275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25275"/>
    <dbReference type="eggNOG" id="ENOG503261Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2670085_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="75" mass="8492" checksum="7AB12FF76376E5FF" modified="2011-06-28" version="1">MTGTDESDRDVDRFQSARNTVLQHRDGRICFHCQGDGCGQHTWAIEELGRHPGGRKLLRQLGFPIDDSTEEGQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FED4</accession>
    <name>F4FED4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Purine catabolism PurC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_25510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734852.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25510"/>
    <dbReference type="EnsemblBacteria" id="AEB46200">
        <property type="protein sequence ID" value="AEB46200"/>
        <property type="gene ID" value="VAB18032_25510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25510"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017436_2_1_11"/>
    <dbReference type="OMA" id="QTLYHRI"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="3">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="5">
        <location>
            <begin position="320"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="4">
        <location>
            <begin position="527"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="592" mass="63243" checksum="303BED1067A61543" modified="2011-06-28" version="1">MFPTVRQVLALDPVRRGAPRLVAGEAGLDRPVRWVHVAEVPDIATLLGGGELVLTTGIGLPADDAGLRAFIADLAGVGVSGLVVELGRRYLTGVPKVMAAAAGRHGLPLVELRRATPFVRITEAVHALIVDAQLTELRATEEIHQRFTELSVEGAEPDEVIRQAAELSGCPVVLENLSRQVLAYDPARENAALLLDGWEQHSRRIRPAGRTAYDPDSGWLVTMVGARGEDWGRLLLRWPGGVDLSPGGTDPSGPGDGESNDADDVVGGLAVPPTRLTILVERAASTLALGRLIRRDAEGWERQIHRTLLTALLDRTRPVDEVALRARALGLTLDRRHLVGVVVRHRGEDPADNGPAADPGGDPGLAGAEPGATRLRDLAETVGQALREAKLTGLTSAVDDQAVGVLLALADAAGEERALTAFAAALRRTRPDSRPPDPASRRPGGLIIAAGSGVGSLREAGRSLIEARQVAEAARRDRRDLPIFRLPHVGLAGLLHLLRDEPRLQTFVERELGALLAYDARHPREQLLGTLRAYLEQGRNKSAAASAAHLSRPAFYERLARIGRILDVDLDSVDACLSLHVALLALDAIRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEF0</accession>
    <name>F4FEF0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734868.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25590"/>
    <dbReference type="EnsemblBacteria" id="AEB46216">
        <property type="protein sequence ID" value="AEB46216"/>
        <property type="gene ID" value="VAB18032_25590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25590"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_1_11"/>
    <dbReference type="OMA" id="AMTQQMK"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="369" mass="40019" checksum="1E80C3AB9A81E4CA" modified="2011-06-28" version="1">MEFVFPVLLIGIALISVITLAKALRIVPQQRQDVVERLGRYKRTLNPGLNLLVPFIDSVRTKVDMREQVVSFPPQPVITSDNLVVSIDTVLYFKVVDSVRATYEISNFLQAIEQLTVTTLRNVIGSLDLERALTSREEINRHLSGVLDETTGRWGIKVTRVEIKAIEPPPSIRDSMEKQMRAERDRRAAILNAEGHKQSQILTAEGEKQAAVLRADGDRQARILQAEGQAKAIRTVFDAIHTANPSQKVLAYQYLQALPQIANGTANKVWIVPAELTKALEGMGGALGGLSQMVGDAPSPKASDDASAVEREAAEAAQAAAAAAQEIHNEVRVAEAQATGGKAPQGLPAPEPVSPTSLLNDPADQRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEF9</accession>
    <name>F4FEF9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736036.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01585"/>
    <dbReference type="EnsemblBacteria" id="AEB47401">
        <property type="protein sequence ID" value="AEB47401"/>
        <property type="gene ID" value="VAB18032_01585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01585"/>
    <dbReference type="eggNOG" id="ENOG503425T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336228_0_0_11"/>
    <dbReference type="OMA" id="TEWISLL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="205" mass="22470" checksum="3DB3A4C26C4AA0C0" modified="2011-06-28" version="1">MEEDLQHLIAQARKSALVDDSDVDQVLARYQKEELTEREAARLLKGLYQGVPLKLAELPGRQVGTEWISLLAGMQEESTQWQNIARSQYRQGFFLLPASVVAVLAATFAGHYWLKFPEKELTALAAAALAALATHSFFVFRVHQQARIAAERLSEKRAAILFVQAALARATPDQAPNILAAAGAMFLGHHAPETIPLQSTDRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEG9</accession>
    <name>F4FEG9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47411.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB47411">
        <property type="protein sequence ID" value="AEB47411"/>
        <property type="gene ID" value="VAB18032_01635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01635"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="IVAHAWI"/>
    <dbReference type="OrthoDB" id="374938at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="41"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="32164" checksum="3EB74F384A8F9091" modified="2011-06-28" version="1">MDLTDTLELPAHAHPGPPDSVPVDAGLSIFDPVFLGIDEFGQPVYLPMIYRNILIGGEPGSGKSSLLNTIVGHAALCADVRLCLLDGKQVELGLWEDACDVFVGPDIDHAIRTLRRVQTVMDNRYTFLKARRRRKIGPHDVFGQILVACDEIAYFSATAGDEKTQKLFAALLRDIVARGRAVGIIVAAATQRPSSDIIPTSLRDLFAWRFAGRCTTDVSSDIVLGHGWAARGFSSNTVDPNNHGAGYLIAEGGIPTLVKAAYLTDADIIRVADYATWTRRRTNSLTTDHTNPARAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEJ9</accession>
    <name>F4FEJ9_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Glutaredoxin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736076.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01785"/>
    <dbReference type="EnsemblBacteria" id="AEB47441">
        <property type="protein sequence ID" value="AEB47441"/>
        <property type="gene ID" value="VAB18032_01785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01785"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125054_2_1_11"/>
    <dbReference type="OMA" id="YWEQIPV"/>
    <dbReference type="OrthoDB" id="2001991at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="83" mass="9630" checksum="C6940CF1AA886F77" modified="2011-06-28" version="1">MREPRLTLITRPGCHLCEDAKAALDRVVAVTGDRWTERDVSGDIELEREYGDRLPVVLLDGKEHGYWRVEEERLLRDLTTPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFD0</accession>
    <name>F4FFD0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Atpase associated with various cellular activities aaa_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734884.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25670"/>
    <dbReference type="EnsemblBacteria" id="AEB46232">
        <property type="protein sequence ID" value="AEB46232"/>
        <property type="gene ID" value="VAB18032_25670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25670"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="OMA" id="DRFMFAI"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="63"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="266"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="369" mass="40068" checksum="D57856C9907D0A80" modified="2011-06-28" version="1">MAQPTTPDAPTPNGTQPQTPGAPTTPAQDAGLLERALFEIKRVIVGQDRMVERMFVALLARGHCLLEGVPGVAKTLAVETLAKVVGGSFARVQFTPDLVPADIMGTRIYRQSSEKFDVELGPVFVNFLLADEINRAPAKVQSALLEVMSERQVSIGGESHRVPNPFLVMATQNPIEQEGVYPLPEAQRDRFLMKIVVGYPTDAEEREIVYRMGVAPPEPTAVFDTDDLIALQNKADQVFVHNALVDYAVRLVLATRTPAEHGMPDVAQLIQYGASPRASLGLVRATRALALLRGRDYALPQDVQDIAPDILRHRLVLSYDALADDVPADHVVHRVMSTIPMPSVAPRQQATPTPPAAVAPTSGWPGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFK2</accession>
    <name>F4FFK2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic binding protein/LacI transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736113.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01975"/>
    <dbReference type="EnsemblBacteria" id="AEB47479">
        <property type="protein sequence ID" value="AEB47479"/>
        <property type="gene ID" value="VAB18032_01975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01975"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="HERVERY"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="335" mass="35459" checksum="65C7912E1801475E" modified="2011-06-28" version="1">MTGAQRPTLEAVARRAGVSRATVSRVVNGSTTVAEPIREAVRQAVAELGYVPNLAARSLVTQRTDSIALVMPEEATRVFSDDQVFPGIIRGAAQELEAADKQLVLMLAGSPAGHERVERYTTGRHVDGVLFASLHGADPLPAKLAALGIPVVCSGRPLDGANVPYVDVDQVAGVTKAVRHLIDTGRRRIATIAGPQDMVAGIERLAGYRDTVAAAGLPQMVAVGDFTRESGAAAMRELLTAHPDLDAVFAASDLMAHAALRTLREAGRRVPEDVAVIGFDDIETAAYTEPPLTTVRQPIVELGRQGTRLLLRLAAGEEVEPALILPTELILRDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFN8</accession>
    <name>F4FFN8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02155"/>
    <dbReference type="EnsemblBacteria" id="AEB47515">
        <property type="protein sequence ID" value="AEB47515"/>
        <property type="gene ID" value="VAB18032_02155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02155"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_2_2_11"/>
    <dbReference type="OMA" id="VLFHNNA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="86"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="29313" checksum="6DC6AD1249F4FC31" modified="2011-06-28" version="1">MLGIITLVVTAVLGSAYLLGRSLVPDPPRHDSAVTATGADHPEYADQSAEADPGHPSASPSNPPSPSDGTDPNFGPMGTRLSTGTNEVALTFDDGPNPDYTPQILAILREYHVTATFCVVGQNAQAYPWLVQQIVDEGHTLCNHSWNHDVSLGGRSPDRIRDDLLRTNAAIHAAAPDAPVTWYRQPGGAWTYPVISVSRDLGMTPLHWTLDPSDWRAPGATRIASVVLSEARPGSIVLLHDAGGDRQGTVDALYRILPDLTARFDLQALPKHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFY5</accession>
    <name>F4FFY5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07205"/>
    <dbReference type="EnsemblBacteria" id="AEB42565">
        <property type="protein sequence ID" value="AEB42565"/>
        <property type="gene ID" value="VAB18032_07205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07205"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_0_0_11"/>
    <dbReference type="OMA" id="HEPVAWI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="421" mass="46946" checksum="562F6CC508C39DFC" modified="2011-06-28" version="1">MSQMPVTRTTPTADIAHPATYALGVPHAEFERRRREEPVGWVPEPALWRHSSAGRMQQQGPGFWAVTTHDAVMEVSRQPQVFSSALRGAFLHDPRTPADLDFMRQLLVNMDAPQHVRIRRIVSSVFTPRAVRALADTVTRHAQDLVEAVRQRDNFDAVTDLAAELPLLVLADLLGLPHGDRHLLYRWSNNLVGFDDPEYGGGDVEVYRQTFAEAFQYALAVAVRRRAAPRDDLISLLATAEVDGRRLTDREFCQFWLLLVVAGNETTRHLISNSLHLLLHDEQLRGRWLGSPLPTATAVDEFLRVVTPIMQFRRTATQDTTLAGTRIAEGDKVVMFYVSANRDAAVFADPHRVDLERAPNPHLSFGVGPHFCLGAHLARMEMAALLDAIAPHLPRLAATGPVVRLESNFVNGIKSMPVGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG70</accession>
    <name>F4FG70_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732481.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13510"/>
    <dbReference type="EnsemblBacteria" id="AEB43814">
        <property type="protein sequence ID" value="AEB43814"/>
        <property type="gene ID" value="VAB18032_13510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13510"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_13_11"/>
    <dbReference type="OMA" id="SCVAKQV"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="148" mass="16486" checksum="308443335597D2EA" modified="2011-06-28" version="1">MTSRASAEQLRDLARLRRVRDRIDREYAQPLDVEALARGVNMSAGHLSRQFRLAYGESPYAYLMTRRIERAMALLRRGDLSVTDVCFAVGCGSLGTFSTRFTELVGVPPSTYRRQALTAAAELPACVSKQVTRPIRIREASVGRPQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGF0</accession>
    <name>F4FGF0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual specificity protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733743.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19930"/>
    <dbReference type="EnsemblBacteria" id="AEB45088">
        <property type="protein sequence ID" value="AEB45088"/>
        <property type="gene ID" value="VAB18032_19930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19930"/>
    <dbReference type="eggNOG" id="COG2453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126482_0_0_11"/>
    <dbReference type="OMA" id="RWPDFRL"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="62"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="15001" checksum="8382914EA2E2A9D4" modified="2011-06-28" version="1">MGDWEDDVGVVELPGGVRVRGRRVADPASPADFGLLLAPGPTPAWEHRRVRWPDFWVPTDRADALDALREALRRGYAGQRVEVACRGGTGRTGTALAALAILDGLPAEQAVDWVRAAYRPGAVETPWQRRWLRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGI2</accession>
    <name>F4FGI2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UvrABC system protein A</fullName>
            <shortName evidence="14">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 18" type="primary">uvrA</name>
        <name evidence="18" type="ordered locus">VAB18032_26095</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734968.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26095"/>
    <dbReference type="EnsemblBacteria" id="AEB46317">
        <property type="protein sequence ID" value="AEB46317"/>
        <property type="gene ID" value="VAB18032_26095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26095"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_11"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="614"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="960"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="646"/>
            <end position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AEB46317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="994" mass="108606" checksum="4152134F2F1C4845" modified="2011-06-28" version="1">MADRLIIRGAREHNLRDVSLDLPRDALIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSSYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITEVYDYLRLLFARVGEPHCPVCGERISKQSPQQIVDRVLAMAEGTRFMVLAPVVRGRKGEYVDLFAELQAKGYARARVDGVVHQLTDPPKLKKQEKHTIEVVIDRLSVKPSAKQRLTDSVEAALGLSGGLVLLDFVDVPEGDPERERRYSEHLACPNDHPLAIEDLEPRVFSFNAPYGACPECTGLGTKKEVDPELLIPDPERTLREGAIQPWATGHNLEYFLRLLEALGEAQHFDIDTPWRALPSRAQKTILHGSDDQVHVRYRNKYGRERSYYTGFEGVVQWIERRHSDTESEWSREKYEGYMRDVPCAACGGARLKPEVLAVTLAGRSIAEVCNLSVGECADLLAGIELTDRQKLIAERVLKEINARLRFLLDVGLDYLSLDRPAGTLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNHRLIETLVRLRGLGNTLIVVEHDEDTIRTADWIVDIGPGAGEHGGQIVHSGSVPALLANPDSITGAYLSGRREIPTPKGRRPQTPGRELVVHGAREHNLRNLTVSFPLGQLIAVTGVSGSGKSTLVNDILYAVLANQINGARLVPGRHTRVSGLEHVDKVVGVDQSPIGRTPRSNPATYTGVWDHVRKLFAETTEAKVRGYGPGRFSFNVKGGRCEACSGDGTIKIEMNFLPDVYVPCEVCKGARYNRETLEVHYKGKTVSDVLEMPIEEAAEFFSAIPAIHRHLKTLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGRTVYVLDEPTTGLHFEDIRKLLMVLEGLVDKGNTVITIEHNLDVIKSADWLIDMGPEGGHRGGTVLATGTPEEVAEVAESHTGQFLRTVLKLDGTAKGAAAATARAAKANGNKTTGTKTAATKTTATKARAGRKSVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGL4</accession>
    <name>F4FGL4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_26255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735000.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26255"/>
    <dbReference type="EnsemblBacteria" id="AEB46349">
        <property type="protein sequence ID" value="AEB46349"/>
        <property type="gene ID" value="VAB18032_26255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26255"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="EHDMRFI"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="29"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="31335" checksum="A655624AFADFF03A" modified="2011-06-28" version="1">MGETVQKPTVPEQAGAPAVESTAKREPLLEVDHVTLRFGGVVALNDVNFTLYKGEILGLIGPNGAGKTTCFNAMTGIYQPSEGEIRFRGERITGKKKHHITKMGMARTFQNIRLFPEMTALENIQVGADAHHKTSVLSALFRLPRHRREERDGLQKAERLLEFVGIPHRMHDAARNLSYGEQRRLEIARALATDPVLLCLDEPAAGFNPAEKEELLQLIRKIRDQGITVLLIEHDMRLVMGVTDRIVVLEFGKKIADGLPAEVREDHRVIAAYLGVPDDDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGU5</accession>
    <name>F4FGU5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ordered locus">VAB18032_02605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736238.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02605"/>
    <dbReference type="EnsemblBacteria" id="AEB47605">
        <property type="protein sequence ID" value="AEB47605"/>
        <property type="gene ID" value="VAB18032_02605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02605"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_1_1_11"/>
    <dbReference type="OMA" id="ERQHSVY"/>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="24227" checksum="53DB97C595500218" modified="2011-06-28" version="1">MTAQLNPRGDVAVLVPAAGAGVRLGPGRPKALRLLAGEPLLVHAVRRLAAAASVHTIVVAAPIAEVAAVRELLAPIAPVTVVPGGAERQESVAAALAAVPVGPDIVLVHDAARALTPPALVESVAAAVRSGHDAVIPVLPVVDTIKEVDADELVLGTVDRRALRAVQTPQGFRRSVLAAAHAAAGDALTDDAGLVEKQGVPVFCVPGSDHALKITRPFDLALAEHLLATGLRTRTLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH44</accession>
    <name>F4FH44_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07690"/>
    <dbReference type="EnsemblBacteria" id="AEB42658">
        <property type="protein sequence ID" value="AEB42658"/>
        <property type="gene ID" value="VAB18032_07690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07690"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_11"/>
    <dbReference type="OMA" id="ITTWHIS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="59"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="761" mass="84351" checksum="44C64668BF18ED6E" modified="2011-06-28" version="1">MISEQNVDSSDGSQGSDRGTAAPVWHVPIDSRAYFTGRNDLLNLLYQEATSSGRAILTHGLTGQGGVGKSRLAAEYAHRHRKDYDLIWWVRSSAQSAMNEDLARLGEELGVWAPSSSRWREAGAKVREWLEATDSKWLLVFDDVEEPEALQRALPSKGRGHVLITARNPSKVPANVRPVSVDVLPVESAVHFLLTRTGATDDDGAEKVARELGGLALALEQASAYIAATGVGFGEYLRRIGRYRRRSKGNNFRLGRLRKPSAEDRVMDVLEASCMLSMDTVTEAEPWSRSILEYLSFLDSSPIELRLLRELEPSLKISVRPLRTLSRYALIEFAADESAVIHPSVQQIMRSRMDAVRQNVVRQRLIQWLEVAFPEQADDRRSWRICGALAPHVASVLDNTARYEELSAQLLLHRLGKYLYSRGDSRSSLLYLQRAASAILRSATSPADVSDVILNDLAVVWADEGDWARAVEVGVEIFQRRLARVPEAAVDGPLVAFASNVAAALADSGRLIDADEIYRWLHSNSIKVAPSMELELFSALVAARHNWASVRGELGDVAAAESGYREVLNDKIIEYGSAHPETVVSLLGLAQILRKRGDFQGALALAENAFNCAERVLGEYHPLTLSALDLLAALSDDNDELPASFVFAERAYGRRRDAVGVDHPSTIEALYNLASITRRSGDPRHATELFERLVRVLEETLGPKHPKTVGVVRELTLLRDKSGSLVSRTRSFVDDMRSHVDDETSSVTRRRLFLQQVEVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH48</accession>
    <name>F4FH48_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_07710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07710"/>
    <dbReference type="REBASE" id="34479">
        <property type="entry name" value="M.VmaORF7710P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42662">
        <property type="protein sequence ID" value="AEB42662"/>
        <property type="gene ID" value="VAB18032_07710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07710"/>
    <dbReference type="eggNOG" id="COG0270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006958_3_0_11"/>
    <dbReference type="OMA" id="FIEWRII"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="392" mass="43125" checksum="6FD781BC3642EF3E" modified="2011-06-28" version="1">MTQLALIRSDAGTAKPTAAEFFAGIGLVRLGLEDAGFKVIWSNDIEPDKKEMYVRHFNDPEGTHTYKRGDIADVRGPQMVDELSLAWASFPCTDLSLAGARRGLAGSESGTFWHFVRVLREMGDRKPPVVALENVVGLATSHGGEDLAAAIRALNDLDYSVDVLTLDARRFVPQSRPRLFLVGALEPPADEPVPNSELRPDWLQAPFGDPGLRTHRALLPAPPPPKTTGLTELADKLPPDSELWWDDQRQAAFVSSLSPIQAERLETLRKGRKISRRTAYRRTRAGKPTWEIRPDDISGCLRTARGGSSKQAVVEAGQGKVRVRWMTPREYAKLMGAADYRLDGLRTNQALFGFGDAVCVPVVAWLGREYLMPLVRGELRSAESPRLAVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHL5</accession>
    <name>F4FHL5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26430"/>
    <dbReference type="EnsemblBacteria" id="AEB46384">
        <property type="protein sequence ID" value="AEB46384"/>
        <property type="gene ID" value="VAB18032_26430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26430"/>
    <dbReference type="eggNOG" id="ENOG502ZEXS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1072883_0_0_11"/>
    <dbReference type="OMA" id="WFIFIAA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="30995" checksum="3065D869DB5B83C7" modified="2011-06-28" version="1">MNVSTFDEYAALVRHLSTQQRASEQGVAADEQRRRDLGATVEYLDRRLLAQGQRLDQLGRTIGVTSPPPGPSGTAPTSGPPGSMPTSGPPGPPGVPTSGPPAPSGHAGAGGSGPGTGWDGGAAAAPGRSGVGAYPQVSVGEAERALPVAVSATAAGVPGQRAGEVDAATELEMARRWADEADRYAQQTEVLAQQPALLPTWSPMARAFAVYLAFAAVSVLIMLVMVLASGVGVVGGWTLFSWMCAGLPAASLIGGWLVLGRWGRPAVGAMTAPRYPVIGFLLCFLAVPLAYCGYLILIRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHT5</accession>
    <name>F4FHT5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26906"/>
    <dbReference type="EnsemblBacteria" id="AEB46454">
        <property type="protein sequence ID" value="AEB46454"/>
        <property type="gene ID" value="VAB18032_26906"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26906"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061533_2_0_11"/>
    <dbReference type="OMA" id="CHGVLEY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="25168" checksum="1BC4F7AF654BEF01" modified="2011-06-28" version="1">MEQTPGAAGPPLTPRTAVVWSVLRAELDRRPSAELTVLDVGGGTGGFAVPLAQAGHRVTVVDASPDALAALSRRAAEAGVADRVRAVQGDGDALAGLVEPDSVDLVLCHAVLEVVDEPASVVAALATALRPGGAASVLVAGRSAAVLGRAMNGHLDVAATLATDPTGTAGPRDTLRRRFDAESAAALLTAAGLTVEEIHGVRVLADLLPAAVADGQQGALVELERALAARSPWRDLAVQLHLFARRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHW4</accession>
    <name>F4FHW4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736289.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02865"/>
    <dbReference type="EnsemblBacteria" id="AEB47657">
        <property type="protein sequence ID" value="AEB47657"/>
        <property type="gene ID" value="VAB18032_02865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02865"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_0_11"/>
    <dbReference type="OMA" id="TMDWMAV"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="191" mass="20961" checksum="D043AA0BEF5E1791" modified="2011-06-28" version="1">MADGSWYDADIDHVIISEAQIREKTAELAKQVSADYAHVTDGLLLVCVLKGAVMFMADFARALGRQGPPAELDFMAISSYGQGTTSSGVVRILKDLDRDIAGRHVVVVEDIVDSGLTLSWLLRYLESRSAASVEVVALFRKPDAVKVTVPVKYVGFDIPTEFVVGYGLDFGERYRELPYVGVLKPEVYARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHZ7</accession>
    <name>F4FHZ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anion-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736322.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03030"/>
    <dbReference type="EnsemblBacteria" id="AEB47690">
        <property type="protein sequence ID" value="AEB47690"/>
        <property type="gene ID" value="VAB18032_03030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03030"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058953_0_0_11"/>
    <dbReference type="OMA" id="EMPVQET"/>
    <dbReference type="OrthoDB" id="1148570at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="325" mass="34236" checksum="B746426E4D3D4D64" modified="2011-06-28" version="1">MGATQRPADRAGTDWPARLHVVTGKGGTGKTSVAAALALGLAAGGRRTLLVEVEGRQGIAQLFGTQPLPYAERHLVDARDGGEVYALAVDAEEALLEYLDMFYKLGAAGRALRKLGAIDFATTIAPGLRDVLLTGKVKEATTRTADGRRVYDAVVLDAPPTGRIGRFLNVTAETARLAKVGPIKTQSEGVAALLRSPMTAVHVVTLLEEMPVQETIDAIGELTSLGFGVGKVIINAARPPLPTGQLVTEAELEHGLRAAGLPVEQRLVAGLHDEARDQVIRRELEDSLRADLVELGIPLVELPLLPGGMDRAGLDVLAAALLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F134</accession>
    <name>F4F134_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731361.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42688">
        <property type="protein sequence ID" value="AEB42688"/>
        <property type="gene ID" value="VAB18032_07850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07850"/>
    <dbReference type="eggNOG" id="ENOG502ZGFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2784594_0_0_11"/>
    <dbReference type="OMA" id="AREWVWS"/>
    <dbReference type="OrthoDB" id="2030026at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="76" mass="8885" checksum="04A9711282B856D3" modified="2011-06-28" version="1">MPLLRVHLDSDRITARRVMHLHQEGKIHHESREAAREQVWRQGRTPAGDPIFVGITNGRRNVQLLYDVEVYSDTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F149</accession>
    <name>F4F149_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_07925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731376.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07925"/>
    <dbReference type="EnsemblBacteria" id="AEB42703">
        <property type="protein sequence ID" value="AEB42703"/>
        <property type="gene ID" value="VAB18032_07925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07925"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_11"/>
    <dbReference type="OMA" id="EINARHE"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="175"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="386" mass="41754" checksum="3B1E82CFDBB6DC30" modified="2011-06-28" version="1">MKRLTLRARLTLVYGGLFLLAGIVLLGVTYVLVEQRTSQSLQTDFSDLRTVTTPRALPTEQDFERVRLLVQNVQREAKRDALESLLTQGGLALVVVSAAAVAIGWLIAGRALQPLHQITGTARRIAGADSAGRGLHERIALTGPRDEVRELADTFDQMLERLDRSFDGQRRFVANASHELRTPLTLNRALVELAVSRPDAPAEVRRLGEALLSVNERHERLIDGLLTLADSENELTERAGVDLAEIAAYVLDQAGTASPGIPVRRSLDPARTVGDPVLLERLTFNLVENALRHNVPVDGWVEVRTGVVAGRPTLVVINTGPAVPGYDVETMFQPFRRLSRERVAGGRGFGLGLSIVRAVARAHGGTAEAEPRSGGGLTVTVTLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F161</accession>
    <name>F4F161_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731388.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07985"/>
    <dbReference type="EnsemblBacteria" id="AEB42715">
        <property type="protein sequence ID" value="AEB42715"/>
        <property type="gene ID" value="VAB18032_07985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07985"/>
    <dbReference type="eggNOG" id="COG4103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670730_0_0_11"/>
    <dbReference type="OrthoDB" id="1476426at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="410" mass="43901" checksum="E03421068FDF38EB" modified="2011-06-28" version="1">MLAAADSLWPTDLRGMAMDLRGVGLGRLKGVADAAGRMVVDSTSVARQRVADVAGDAQDKVKQSAEQVMAKVVEVKDGLSARTSRDRADVGDLSALTADGKLLYCRVLVSLALVDGLLDPREIANLYLFASMIGLDDEARSQLRSDITGAQRDTASRAGIPDATVELARELRDLLDEDQREPVFTVLVRDLVRISRADRHAADAERERIVLVAELVFTESAGQVVEATERFVVTEEDFASGRITTSQLEAATKDIAVKAAAFGAPIAAISLAGSVSGLSGAGITSGLAALGFGGLLGLSAMATGIGTVVILGVVVHQGARYVLATNEREREKRREHLIQQVIKNHQQAMAELTDDIAGLARRMDAYLTQTTRNEERLATLRAELAAFQSALVNLQTSQELFEQREPLRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F163</accession>
    <name>F4F163_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731390.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07995"/>
    <dbReference type="EnsemblBacteria" id="AEB42717">
        <property type="protein sequence ID" value="AEB42717"/>
        <property type="gene ID" value="VAB18032_07995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07995"/>
    <dbReference type="eggNOG" id="ENOG5030HNI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1711141_0_0_11"/>
    <dbReference type="OMA" id="ANDTFCH"/>
    <dbReference type="OrthoDB" id="2194592at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="155" mass="16863" checksum="272490E34EF7B602" modified="2011-06-28" version="1">MSLVTGETDGGILLIANDDTFAHTYPDLRRLLEEQAEGDPLRGAVEFFDFTGRRLVPGFDRQWCLTDLQPSSEPADPAAVQRRLQAVLDHLERFLKSDSESGGGSRVDGAATVRELPALDGTLADAIEKMPWHEPGKGTAGNFLHNAMHAAGWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F176</accession>
    <name>F4F176_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732579.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14000"/>
    <dbReference type="EnsemblBacteria" id="AEB43912">
        <property type="protein sequence ID" value="AEB43912"/>
        <property type="gene ID" value="VAB18032_14000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14000"/>
    <dbReference type="eggNOG" id="ENOG50337CU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125454_0_0_11"/>
    <dbReference type="OMA" id="GWYVDRA"/>
    <dbReference type="OrthoDB" id="1678516at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="161" mass="17759" checksum="043FFAE4B6C469A3" modified="2011-06-28" version="1">MPGRTVGVVRAENGPDWREQRRRAVAAHAAADERRRASEQVAAAELVAWFVTEARRRGIPPERLTARSYDGRGRYRTRLRGWYVDRARSRAIDVDGRFHLLTVPGSLRARLFGADPQPSPPPLVVGAGGRDGESMPLRTMLSRRLTDDGPDTTTVAAPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1H0</accession>
    <name>F4F1H0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733853.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20495"/>
    <dbReference type="EnsemblBacteria" id="AEB45199">
        <property type="protein sequence ID" value="AEB45199"/>
        <property type="gene ID" value="VAB18032_20495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20495"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_4_2_11"/>
    <dbReference type="OMA" id="ERTQIQL"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="16569" checksum="E07238B097CECF8D" modified="2011-06-28" version="1">MTIPSPGRPSDLMFLLSWASHALRAEHAVGLAELGITPRDHCVLARARAGGLTQRQLGELCGVDKTTMVVTLDHLEAAGLARRVPSPTDRRARLVEVTTQGEQVLDQAQEIAAGLEQDVLAALPDSEREVFLSAVQRLVGGRLSRVNACGPAGSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1J5</accession>
    <name>F4F1J5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20620"/>
    <dbReference type="EnsemblBacteria" id="AEB45224">
        <property type="protein sequence ID" value="AEB45224"/>
        <property type="gene ID" value="VAB18032_20620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20620"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_0_11"/>
    <dbReference type="OMA" id="AFQKGFH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="206" mass="22030" checksum="ECC81A45F81F3D53" modified="2011-06-28" version="1">MKHSAQRTAVLVIDMQNDFCSPAGAMAALGADVQVNTAVAGRLPSFLDRARHAGCLVVWVRQAAHEQLVSPARRARAEAMGRSPLSVCAAGSWGAELAEGLRPEPGDCHLEKTRYSAFVGTPLHNLLRAHGRDHVVVVGTAANVCVDSTIRDAYMADLATTMPTDLVGWTRADLAEAAIRNLGFYFCETTTSAELLSDWSVVDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F235</accession>
    <name>F4F235_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase S8/S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_03490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AEB47782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AEB47782">
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        <property type="gene ID" value="VAB18032_03490"/>
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    <dbReference type="eggNOG" id="COG1404">
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    </dbReference>
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    <dbReference type="OMA" id="GPVQPME"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
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        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUBTILISIN"/>
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    </dbReference>
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        <property type="entry name" value="SUBTILASE_SER"/>
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    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003313504" evidence="12">
        <location>
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            <end position="418"/>
        </location>
    </feature>
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        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="13">
        <location>
            <begin position="53"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
            <begin position="386"/>
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        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB47782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="418" mass="43784" checksum="ED751386A5823D2E" modified="2011-06-28" version="1">MGALLTTTLTLPAPAHAAPEICQNPSDPGEVNTETPWHQRWLAPQRVWPFSTGAGVRVAVIDSGTDSSHPQLTGRVDSGFDALRNAPGGDVDCVSHGTAVASIIVAARQEGVGFHGLAPDATIVPIRVSERNANESTDTAGATVGGAVFAQAIMRAVEDGADVINMSVTLYRPDPDVQRAIRYAVDNDVVLVAAAGNRHQDGARPDPVPYPASYDGVIGVGAVDQNGARIRQSQIGPYVDIVAPGGAVVAATRLTGHAAYDGTSFATPMVSATAALIRAAEPNLSAKEVTRRILATADPARGDAARGYGSGVVNPYRAVTERLTSAKPVAQPPLPEVPLDAAAQAREQRWALFGRLALWIGLGLATVAVGVAVLAALLPRGRRTRWRPTRPAASPDDRPEIDEPEEVFFRVPTSTSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AEB44009">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
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        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="31091" checksum="49996376AEEF49C7" modified="2011-06-28" version="1">MTFTLYPDTRLTLARDSLAGLSVGDALGSQFFVPGRQPADLAAGLLPPAPWQWTDDTEMACSVLAALAQTGSIDRDALAVAFAERCEPYRGYGPGAVRILRLIRTGTPWPVAAAAAFDGQGSCGNGAAMRVAPLGAYFADSTSRAAAQAQASAEVTHAHPEGIAGAVAVAVAASLAARARLDGDRPDPARLLAGVAAALDPATEVHRGVRRAVDLLGRPLAEVVAALGNGSRVTAQDTVAFTLWVAASYLEDYPAAVRACVEAGGDVDTTAAIVGGTVAGYTGVGTSGGVPTGWLAAREPLPEWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2K8</accession>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="VAB18032_20865"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2091142at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="67" mass="7108" checksum="63A0F20586D069DD" modified="2011-06-28" version="1">MTNPQQQELRRNALGATSQDSKGPGPTGHPRNRGTSRADAGRPVPRGQVSPYGPTGQPVAQDESDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2M5</accession>
    <name>F4F2M5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733944.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20950"/>
    <dbReference type="EnsemblBacteria" id="AEB45290">
        <property type="protein sequence ID" value="AEB45290"/>
        <property type="gene ID" value="VAB18032_20950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20950"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093167_0_0_11"/>
    <dbReference type="OMA" id="AYNDHDS"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307619" evidence="2">
        <location>
            <begin position="42"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="232" mass="24558" checksum="99CF1C8E8B08366A" modified="2011-06-28" version="1">MKFDFTRWLPAIATNPNRKTTLSVVGVTALAGLAFGPTAVAAPLTTGPHEGAVAAIDKATGRETTGTTVESALTTGGRTDKPSAGKPSRGELIPHGVQGAQSRVPLDGAQRENAKTIIEVAKKTGVGERGAVIGIATALQESKLYNLGHLGAYNDHDSQGLFQQRPSSGWGTEAQITDPEYSSNAFFQALKNVNGWRDMPLTAAAQTVQVSAYPFHYAQWEEQAADIVSQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2S9</accession>
    <name>F4F2S9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27336"/>
    <dbReference type="EnsemblBacteria" id="AEB46540">
        <property type="protein sequence ID" value="AEB46540"/>
        <property type="gene ID" value="VAB18032_27336"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27336"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030487_0_0_11"/>
    <dbReference type="OMA" id="CYDQGRL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="441" mass="48135" checksum="828FDF5E5E507EF5" modified="2011-06-28" version="1">MAVDEEPEPPADPEQVLASYRWRLDPEDLREVVDDPEELRTVRQRLTDKLASALDNRSRARLLSLRAVASRVLGDLDDALDDGRMALTYAEATGELRRVALAQARLAHVLRWRGDFTEADRLFAEANSAELPDRLRAALHEHAARSCYDQGRLMEACHHFERALDLRGEGDAELLARVRIGLDAVAARAAERGFGPYPRGWDEVLDRDRSPVPARDGGQGLWGYADAAGDMVVPARYTEAQPFSDGLAWVRGPESDRWSLIGPTGEVVVGPTYLAAQPFSDGLAWVVRDDSGWLAVNTTGEVVVPPGFGDVRPFRKGVAAVRREGWGAVDAAGQIVLPTRYHGFHTRLADGRYVDGFTDEGLAVVDLAGRKGVVDRTGQVIVAPAHPALLIHPVAFLATNGVGRWGALDRRGAPLIDPVFAHPNDVITQIESLLTDTTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Z2</accession>
    <name>F4F2Z2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27651"/>
    <dbReference type="EnsemblBacteria" id="AEB46603">
        <property type="protein sequence ID" value="AEB46603"/>
        <property type="gene ID" value="VAB18032_27651"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27651"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_21_8_11"/>
    <dbReference type="OMA" id="TQYIQMG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="581"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="867"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1040" mass="110926" checksum="2930E0069A976043" modified="2011-06-28" version="1">MRVLVVHGAWLPGRGLAVWGEDSTLPPRAARRPGRVPRERPHPFAAAHTTLAAALAEVAEPTDLGTALLRLPTRAGSPVDSPELVRTAVVDPVRGPVTLAGWRVPILAYAPDAALSLLRTLDGLTAVPGATLRHLAELATFAADLATRGRVLPGLAAGRGSEVGARAVWRPLLTGTDAAWARALALALPPVARAVAEADLPATAVPTGAGLEAEGAAGAGVLVGDALDALTDAAVRAALPQTTLARGVRRDGAVAAWLGALTGPQREFTAEPAALDVLRDELEAWQRDAAGGTVRASFRLVEPPDDEIETPLTVVPADPDAIVATEGTWRVEFGLRAADESGLHVDAGQVWWGTTGPALDSPQETLLAELGRASRLWPELDSALRTATPEAMELDAEGAHRFLREGAPLLHAAGFTVLLPSWWQRPSARLGARLRAASRTAPGTVAAAGERVGLDAIVDYRWEIALGDQPLTAEELARLAELKTPLVRLRGHWVELDPKRLAAGLRLLRSTGELTVADLLRLGLTDAEQPDALPVLEVSADGALGDLLAGSVERRLAPLTEPPSFAGTLRPYQRRGLAWLTFLQSLGLGGVLADDMGLGKTVQLLALFAADPPQAGPTLLVCPMSLVGNWQREAARFTPELRVHVHHGAQRARGAEFGDAVQAADLVLTTYPTAARDAADLAGVDWHRVVLDEAQAVKNAATRQAEAVRALPARHRIAVTGTPVENRLADLWSIMQFANPGLLGPAATFRKRFAEPIERHGDTDTAERLRRITGPFVLRRLKTDSSIISDLPEKLEMEVVCNLTAEQAALYQVVVDDMMARIEASEGIERRGLVLATMTRLKQVCNHPAQLLRDGSALAGRSGKLARLEEILDEVLAAGEKALLFTQYAEFGGMLRGHLSARFGREVLFLHGGLGKADRDEMVTRFQSDDGPALFVLSLKAGGTGLTLTAANHVVHVDRWWNPAVEDQATDRAFRIGQRRRVQVRKFVCAGTVEEKVAALIADKRSLAASVVGTGEQWVTELSTTQLRELFSLEAGAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F360</accession>
    <name>F4F360_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_03785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736471.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03785"/>
    <dbReference type="EnsemblBacteria" id="AEB47839">
        <property type="protein sequence ID" value="AEB47839"/>
        <property type="gene ID" value="VAB18032_03785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03785"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096819_0_0_11"/>
    <dbReference type="OMA" id="EQQCADA"/>
    <dbReference type="OrthoDB" id="1642919at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="72"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="221" mass="23920" checksum="CBD36D7FA6CCBFDE" modified="2011-06-28" version="1">MTARTFTHPSVLAGITAGAAWADPTMNPADIDWTARRATAAIPFPLVDGRPVNPYAPTGIRYGRNELGHWGEQQCADAIVTATTDDMRWLLLIERGDGHGWALPGGYVDPGEDPTAAAFRELAEETGLTADPTDPWVRTLPARYVPDPRASDEAWMVTTPVRIDLGQGWHTPPPVTGRDDARRAAWIAAADYASLTAHLADTYGGQVFAAHRDLIADILTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F375</accession>
    <name>F4F375_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, central region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736486.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03860"/>
    <dbReference type="EnsemblBacteria" id="AEB47854">
        <property type="protein sequence ID" value="AEB47854"/>
        <property type="gene ID" value="VAB18032_03860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03860"/>
    <dbReference type="eggNOG" id="COG3958">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_1_11"/>
    <dbReference type="OMA" id="KVDVCYN"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="298" mass="31420" checksum="ADE711BF67D28C36" modified="2011-06-28" version="1">MRDCFVDTTTALLAEKPRTALVLADISASLFASAAERHPDRVLNVGIREQLMVGVAGGLALTGLRPIVHSYAPFLVERAYEQIKLDLDHQAASAVLVSVGGSFDRAESGRTHFSPADVALFDTLADWTVHVPGHPGEVSGLLRATVAADTSAYLRLSTLHNDRPYADAGDLVVVRDAGPGAALLVAVGPMLDAALAAVADLPVTVAYTHRPRPFDVAGLRALAGTEVILVEPYLAGTSARVVSAALADRPHRLLALGVGREELRRYGSAEDHLRWHGLDPAGLRRSLTGFLTPAAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3E0</accession>
    <name>F4F3E0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_08730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731535.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08730"/>
    <dbReference type="EnsemblBacteria" id="AEB42864">
        <property type="protein sequence ID" value="AEB42864"/>
        <property type="gene ID" value="VAB18032_08730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08730"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_11"/>
    <dbReference type="OMA" id="RKAFEKW"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="29"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="476" mass="51323" checksum="B77E051EE180BEA9" modified="2011-06-28" version="1">MFEYAPAPESRSVVDIKPSYGLFIDGAFVDPADGGSFKSINPASEEVLSEVAEGGPQDVDRAVRAARKVYEKVWGPMPGRDRAKYLYRIARIIQERSRELAVLESLDNGKPIKESRDVDLPLVAAHFFYYAGWADKLNHAGFGANPQPLGVAAQVIPWNFPLLMLAWKIAPALAAGNTVVLKPAETTPLTALLFAEICQQADLPPGVVNIVTGAGETGRALVEHDGVDKVAFTGSTDVGRAIARAVAGSRKKLTLELGGKAANIVFDDAPVDQAVEGIVNGIFFNQGHVCCAGSRLLIQESVADQVLESLKRRMAQLRVGDPLDKNTDIGAINSAAQLARIRELTEAGAAEGAQQWSPPCELPERGFWFAPTIFTGVTQAHRIAREEIFGPVLSVLTFRTPAEAVEKANNTPYGLSAGIWTEKGSRILWTADRLRAGVVWANTFNKFDPTSPFGGYKESGYGREGGRHGLEAYLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3K6</accession>
    <name>F4F3K6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ordered locus">VAB18032_15010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732781.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15010"/>
    <dbReference type="EnsemblBacteria" id="AEB44114">
        <property type="protein sequence ID" value="AEB44114"/>
        <property type="gene ID" value="VAB18032_15010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15010"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_3_11"/>
    <dbReference type="OMA" id="VAVKMCL"/>
    <dbReference type="OrthoDB" id="478143at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="308"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="424" mass="44951" checksum="E97B4704F5136714" modified="2011-06-28" version="1">MTPQELLAADAAHVWHPYATLPPAVPPYLVEAAEGVRLRLADGRELVDGMSSWWAAIHGYRHPVLDAAVTDQLGRMSHVMFGGLTHAPAVELARTLVELAPDGLEHVFLADSGSVSVEVAIKMCLQYQRATGRPQRRRLGTWRGGYHGDTFHPMSICDPEGGMHHLWGDVLPRQVFAPVPPGGFDTPPDPAYEAALVDAVQRHADELAAVIVEPVVQGAGGMRFHHPHYLRVLREVTRAHGVLLIFDEIATGFGRTGTMFAAEHAGVVPDVMCVGKALTGGYLTLAAALCTPEVAAGIRTGGVLAHGPTFMGNPLACAVANASLGLLRAGDWAGQVARLQRHLRAGLEPLRGLPGVADVRVLGGIGVVQLDHEVDMAAATAAAVGQGVWLRPFRDLIYTMPPYVTDDADLARIAAAIGAAARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3L0</accession>
    <name>F4F3L0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="11">RNAP omega subunit</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">rpoZ</name>
        <name evidence="12" type="ordered locus">VAB18032_15030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007075826.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15030"/>
    <dbReference type="EnsemblBacteria" id="AEB44118">
        <property type="protein sequence ID" value="AEB44118"/>
        <property type="gene ID" value="VAB18032_15030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15030"/>
    <dbReference type="eggNOG" id="COG1758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125406_1_1_11"/>
    <dbReference type="OMA" id="QHADSKY"/>
    <dbReference type="OrthoDB" id="1864134at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB44118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="87" mass="9445" checksum="5BB1F8892E143D9E" modified="2011-06-28" version="1">MGSIANPEGITNPPIDELLEKTTSKYALVIFAAKRARQVNAYYSQLGEGLLEYVGPLVETTPQEKPLSIAMREINAGLLTAEPTDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3L5</accession>
    <name>F4F3L5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732788.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15055"/>
    <dbReference type="EnsemblBacteria" id="AEB44123">
        <property type="protein sequence ID" value="AEB44123"/>
        <property type="gene ID" value="VAB18032_15055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15055"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_2_0_11"/>
    <dbReference type="OMA" id="THPDPYP"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="422" mass="45761" checksum="FE79DB7F06824561" modified="2011-06-28" version="1">MDPAETFATLMSPEGRLDPYPAYERLRAHGPVVQTGPGVYAVTGYPEVDELLRDPRMRVSDDKWRDMMLPQWRDSPALSTIARSMLETNPPDHSRMRRLAAGAFTPRRIAAMRDVVAAQADELIEAMASAGRGGRPVDFMADFAYPLPVAVICALLGVPAADRPLFRRWAADLTGVLEPEITWDELVVADAGATELVGYFTELVAARRRRPADDLTTALVQAHDAGDRLTGDELLANLVVLLVAGFETTTNLLGNGLAVLLAHRGAADVLRRHPEHAPAYVDELLRYDSPVQLTSRTSSETLRAGGVELPAGSWVLLLLGAANRDARRYPDPARFDPWRALLSPLSFGAGPHYCLGAGLARLEGQVAFTRLLRRLPALALSGTPRRRSRLTLRGYETLPVTVGELAPVADHGAPVGATPDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3V4</accession>
    <name>F4F3V4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-6 DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734058.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21525"/>
    <dbReference type="REBASE" id="34484">
        <property type="entry name" value="M.VmaORF21510P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45405">
        <property type="protein sequence ID" value="AEB45405"/>
        <property type="gene ID" value="VAB18032_21525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21525"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022127_0_0_11"/>
    <dbReference type="OMA" id="PFNERDW"/>
    <dbReference type="OrthoDB" id="791672at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="2">
        <location>
            <begin position="144"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="653" mass="68876" checksum="73010C344B3FF646" modified="2011-06-28" version="1">MQVKPTITAAEIARLAGVGRAAVSNWRKRHADFPAPVGGTAASPEFDLIQVEQWLCVQGKLAEQATADRLWRRIAPTSESPAAALAAVGTLLLARQRGQRPRRPVDPHLKPLLPDLEALADELGPQGAFDELWQRFSAPGPGRSFATPDDLADLMVGLAGVDGCTVLDPAAGSGAVLRAAVRAGCTTAYGQELDEGLARLAELWLALREVPGDMNVGDSLRADAYAGHTYDTVVCHPPFGATNWGDEELSHDPRWIVGTTPRTEPELAWVQHALAHLRAGGHAVLLMPPTVASRRAGRRIRAELLRRGALRAVIALPPGAAAPHGVPLHLWVLRRPAPDTPPPARTLLVDAAGVDLTTNGPRILAAWQAFDTDPEAEEPGFARAVPVIELLDEEVDLTPARRQPAVAGEATGEQVVRTRERLAALVGDLPALMPQVTPAQKGPDGEFLTVGELIRSGALQLIGPIRATPASEASSGAAPADGGSSGTASTAAGEAADGPRVLTVHDVLDGKPPSGHDDGRLGQQICLAVGDVVVPMVARQLTARVMAAEGALLGRNLYLLRPNPAALDSWFLAGQLRTSTNEKQASSLSGTLRFDIRRAQVRRMSLEDQRVQGAAFRRLDAFESAIRQAATLGAELVQLTADGLASGSLQEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Z0</accession>
    <name>F4F3Z0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735286.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46636">
        <property type="protein sequence ID" value="AEB46636"/>
        <property type="gene ID" value="VAB18032_27816"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27816"/>
    <dbReference type="eggNOG" id="ENOG503426S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2191333_0_0_11"/>
    <dbReference type="OMA" id="HPGDGWD"/>
    <dbReference type="OrthoDB" id="1762781at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="109" mass="11412" checksum="07BF0CEB6F455137" modified="2011-06-28" version="1">MASNTSKTARASVRAGQAGQGGALSVLGEFKYLIPLNGGKHAYVRNLTNGKTVHLRTDSEAFVEEIRVLAAAGHAAKIRAEINSLNAAHPGDGWDAAEKRLVEAGVFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F486</accession>
    <name>F4F486_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Prephenate dehydratase</fullName>
            <shortName evidence="10">PDT</shortName>
            <ecNumber evidence="3 10">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pheA</name>
        <name evidence="13" type="ordered locus">VAB18032_04085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3 10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736531.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04085"/>
    <dbReference type="EnsemblBacteria" id="AEB47899">
        <property type="protein sequence ID" value="AEB47899"/>
        <property type="gene ID" value="VAB18032_04085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04085"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_0_0_11"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="318" mass="33147" checksum="87343CA694F31D5F" modified="2011-06-28" version="1">MPGTPPTRFAFLGPEGTFAEQALRTLPAAERGTRTPARSVGEALDAVRAGDADAALVPLENSIGGAVGVTLDELAEGEPLVITREVILPVEFVLGARAGTQLSAVRTVAAHPQASTQCRGWLRTYLPDATVIDVLSNGSAAAGAATGEYDAAICAPVGATRHRLAVLADKIADHPDAVTRFALVARPGPPPPPTGDDVTTLAVYIAHDRVGALLSVLMELAVRGVNLSRIESRPTGKALGEYVFFLDCTGHVADVRLGEALQGLRRVCADVRFLGSYPRHRWSGAEGEQPVPAPAGLSDADYADAAAWLARLRAGELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4T3</accession>
    <name>F4F4T3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732889.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44225">
        <property type="protein sequence ID" value="AEB44225"/>
        <property type="gene ID" value="VAB18032_15565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15565"/>
    <dbReference type="eggNOG" id="ENOG502Z7VW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078139_0_0_11"/>
    <dbReference type="OMA" id="IPRSRWL"/>
    <dbReference type="OrthoDB" id="1826062at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="26962" checksum="DE3AF21624CAADFF" modified="2011-06-28" version="1">MTLTPAGSLWATLVMAFVLGALHLLAPYIRRRLPVPTHAAASLGGGIAAAYVFLYLLPRLAEGNQAVAHVLEEKVDATPARGFVLFLVALIGFFTFYVLERATHRSGGHKQEPTRVVFAFQLGFFALYSGLITYTLATKLRAGLGPAVLFTVAMGLHVLATDGVLAQHFPVSLTTRWRLVLVAGAGAGWLTAVVAQPTGLLMNLLTAFLGGGILLNVFVDELTPERHSSLTWFTAGLAAYSGLLAIATFTGTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4U1</accession>
    <name>F4F4U1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45430">
        <property type="protein sequence ID" value="AEB45430"/>
        <property type="gene ID" value="VAB18032_21650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21650"/>
    <dbReference type="HOGENOM" id="CLU_3349987_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="37" mass="4061" checksum="A4BE0F14948FCF15" modified="2011-06-28" version="1">MFRADRPGQLQKDEAPATGRACEVGRQPTRTDLGFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4U4</accession>
    <name>F4F4U4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45433">
        <property type="protein sequence ID" value="AEB45433"/>
        <property type="gene ID" value="VAB18032_21665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21665"/>
    <dbReference type="eggNOG" id="ENOG5033WEA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1460719_0_0_11"/>
    <dbReference type="OMA" id="WWLAYLD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="20632" checksum="A8630855C8E17172" modified="2011-06-28" version="1">MQVSKDGRNWRIGTAADVEWIAGHTTAGISITTAIPPIFDAYATTHQADDVTVAAYEHALVEGLITQTPDQPWWLAYLDTGAHDIVFPRAPRVSLYWNWSYVLVEAGPEQALTWRTGHMRHGRGSLPDLFFPADRSWLVSALWDDTWTCVGGPEPLINALHRDPLANARRVRPNEDALPPGLTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F542</accession>
    <name>F4F542_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735374.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28266"/>
    <dbReference type="EnsemblBacteria" id="AEB46724">
        <property type="protein sequence ID" value="AEB46724"/>
        <property type="gene ID" value="VAB18032_28266"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28266"/>
    <dbReference type="eggNOG" id="COG3689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079638_0_0_11"/>
    <dbReference type="OMA" id="MALNCCA"/>
    <dbReference type="OrthoDB" id="1936285at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="241" mass="26188" checksum="3B618B6F86D5DC98" modified="2011-06-28" version="1">MNRQAQAVVLLLLGGAVLRASLSDLYLRYVKEGLRPFLIAAGLLLVVAAIMTLWYELRPVRTRSDEPADDHDDHTHHEPRVGWLLILPVLGLLLVAPPALGSYAASQSGTALNAPRQSDYPPLPDADPAPVSVLDYAARALFDRGASIGDRRVLLTGFLATGEDGRPILARMVLSCCAADGRPVKLGLTGDVPAGLPDDTWVEVIGRYSDRIGRDPVNDAEIPYLQVESWRPIPTPKQQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F590</accession>
    <name>F4F590_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmA</name>
        <name evidence="6" type="ordered locus">VAB18032_28506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735421.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28506"/>
    <dbReference type="EnsemblBacteria" id="AEB46772">
        <property type="protein sequence ID" value="AEB46772"/>
        <property type="gene ID" value="VAB18032_28506"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28506"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_11"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="84" mass="8790" checksum="537FC30FD914DC72" modified="2011-06-28" version="1">MAHKKGASSSRNGRDSAAQRLGVKRFGGQVVSAGEIIVRQRGTKFHPGDLVGRGGDDTLFALAAGAVQFGSKRGRKTVSIVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5B6</accession>
    <name>F4F5B6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736595.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04410"/>
    <dbReference type="EnsemblBacteria" id="AEB47964">
        <property type="protein sequence ID" value="AEB47964"/>
        <property type="gene ID" value="VAB18032_04410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04410"/>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067049_1_1_11"/>
    <dbReference type="OMA" id="CVFWELD"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="221" mass="23790" checksum="9CD225A892DF1388" modified="2011-06-28" version="1">MSRRLVSLTLDTLEDLPRPCRQCVYWELDPVSADRACAAGDPGLEKEAWVSQTLLEWGSCGKLIYVDGMPAGFVMYAPPAYVPRSMAFPTSPVSADAALLMTANVVPAFAGGGLGRMLVQGVARDLTKRGIKAIEAFGDAKFGDAADPAGACVAPADFFLSVGFKTVRPHPRYPRLRLELRTALSWKSDVEYALEKLLGSMSPESLLRPVRPTPATRSTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5N4</accession>
    <name>F4F5N4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylisocitrate lyase</fullName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_15675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732911.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15675"/>
    <dbReference type="EnsemblBacteria" id="AEB44247">
        <property type="protein sequence ID" value="AEB44247"/>
        <property type="gene ID" value="VAB18032_15675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15675"/>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_2_11"/>
    <dbReference type="OMA" id="QTELWNK"/>
    <dbReference type="OrthoDB" id="1485205at2"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="32087" checksum="4315C5FA0A8CE46D" modified="2011-06-28" version="1">MTYLYARTSTTAKRKALRAGLASGLLLRLPGAFNPLTARLVQQTGFEGVYVSGGALSAAAGLPDIGLTTLSEVAGWAADIAASTDLPALVDADTGFGEPLNAARTIQRLEDAGLAGCHLEDQVNPKRCGHLDGKALIAPQDMVRRLRAAVAARRDPDFLIVARTDARGVEGLTGAIERAKAYVDAGADAIFPEALADEAEFAAFRAAVEVPLLANMTEFGKGPTLDVDQLRNLGYNLVIYPVTTLRLAMGAVEAGLRRLAADGTATGLLDTMMTRSRLYEVIDYDEYSRFDADIASFTLPPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5P6</accession>
    <name>F4F5P6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732923.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15745"/>
    <dbReference type="EnsemblBacteria" id="AEB44259">
        <property type="protein sequence ID" value="AEB44259"/>
        <property type="gene ID" value="VAB18032_15745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15745"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287543_0_0_11"/>
    <dbReference type="OMA" id="VMCRTER"/>
    <dbReference type="OrthoDB" id="20073at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="814"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1031" mass="114998" checksum="11F91BBEC26ED4BE" modified="2011-06-28" version="1">MNRYDAGPVMAGLKDFQRATVAHVIDRYFGTDPTRRFLIADETGLGKSVVARGVIAQTLQRLQDDDSVDRVDVVYVCSNQDIARQNIARLRVTPNETVTLSSRLTLLAKHATELNAAPTTAGKPINLVAFTPGTSFDQGWRTGTAEERALLFLILEQASSWNGWQTRAALRALQAGVASPGRFEEQCNRLWAQLDGKLDRIITGEFLRRARRRGLLHEFDALLDGIGRRPALPDALRETARTLTGALRTTLATAGVEVLEPDLIILDEFQRFRELLDPNGGEGADLARHLFDYRAARVLLLSATPYKPFTLAEEATAGEDHYRDFQQVLRFLSDDESWHADVTKAFEEYRDALVRGEPCGDLRDRLRGLLLRVMCRTERPALVQEGMLREHLTVADNLDARDVHSYVAMRKIAGVVGAPMTVEYWKSAPYFLNFLDGYQLGDKVRAALDGQPHPEVSALLASTQLLDAEAINRREPVDLGNARLRQLAADTIDQGWWRLLWLPPSMPYHALGEPFTTAARDGITKRLLFSSWNATPTAVAGLLSYEAERRLGAVGEGHRHLDYRMEHGRPAAMSVLALFWPHPGLADLCDPLALARQRPDETAPLDVVEREVRERLLAHASGEAEAIEASPTEPWELVFRWPGVDPRPDDAAAALGTSAEEDGTATGLDRHVERARELARDARYPATDHLDGLLGSVAEIGMHGPGNIAWRALSRLIHPDDAVTPAGHWRAAAVLANGLRSLFNRPESAQLLDSLSMGPVYWRAVLRYCAAGDLQAVLDEHLHTLRSGAADTRLDDEEICRLADEARQAIASRPSTYEAFNPHHPDERIKLPGRFALRYGGRGEEQSQVNRKETVRRAFNSPFWPFVVATTSAGQEGIDFHQWCSAVVHWNTPANPVDFEQREGRVHRFGGHAVRRNVAAAHRAEALRSPEPDVWKALYDAARAHSGELGDFAPYWVFPGPAKIERHVLPYPLSRDQAKLDRLKSDLVMYRLAFGQPRQEDLLNLLRRRETGAAAVPDILDLRPSPEWKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Z5</accession>
    <name>F4F5Z5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734207.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22270"/>
    <dbReference type="EnsemblBacteria" id="AEB45554">
        <property type="protein sequence ID" value="AEB45554"/>
        <property type="gene ID" value="VAB18032_22270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22270"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070584_1_0_11"/>
    <dbReference type="OMA" id="RQAHETT"/>
    <dbReference type="OrthoDB" id="1713977at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="149"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="28521" checksum="219B1E2285B081BA" modified="2011-06-28" version="1">MEPTALPLAARDYLDPLAAEMAAFEAIARKADLSVPMPAQVSRYWQLRDLVAHLGGIHRWAVENIRTGKRARQVPKPDDDADLADWYRAGADLLLDELARTDPDAPCWNFSTVPRAAGFWFRRQFHETLIHGRDADLALGELRPVPQLLAADGVDEVLRVMLAVGHRWDGKPVTTLTGPVNVELSDTGHRWVLTPSGNRVPAVSGPRAAAVDEPVAVVRGPAEQVLLLLWQRLPFPDGTHLVSGDTDLVQRLLKSQITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F604</accession>
    <name>F4F604_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22315"/>
    <dbReference type="EnsemblBacteria" id="AEB45563">
        <property type="protein sequence ID" value="AEB45563"/>
        <property type="gene ID" value="VAB18032_22315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22315"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_1_0_11"/>
    <dbReference type="OMA" id="CSAHSAY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010195">
        <property type="entry name" value="Uncharacterised_peroxidase-rel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01926">
        <property type="entry name" value="peroxid_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="177" mass="19114" checksum="6A6C06BF535350E5" modified="2011-06-28" version="1">MQESEFPGIRGPLRFRPETGRPLLDLVEVLLRGPHSLTAGERELIAAYVSGRNECTYCCSAHSAYAAAQLDEGMPLVDQVHADPDRAPISAKLRALLRIAAAVQVSGRDVTADLVQAARTEGATDLEIHDTVLIAAAFCMFNRYVDGLGTLPAADPGWYAQASERIATHGYLPVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F647</accession>
    <name>F4F647_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S8/S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_28641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735448.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28641"/>
    <dbReference type="EnsemblBacteria" id="AEB46799">
        <property type="protein sequence ID" value="AEB46799"/>
        <property type="gene ID" value="VAB18032_28641"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28641"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_7_11"/>
    <dbReference type="OMA" id="ATSWSNY"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309111" evidence="5">
        <location>
            <begin position="38"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="7">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="164"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="41060" checksum="52FC6667E0330A8C" modified="2011-06-28" version="1">MPLPRLYRRGPAATRRPLAALLTAAVLVALTGGPAAAAPATGEIRYADAPAALAGSYVVVLRDDAIGSRATADRLATRYGGHVDQVFTDALRGFEVRLTERAARRMAADPAVAYVEQNRTVTLTVPGVQFNPPSWGLDRIDQRHLPLDGRYAYPNTAPNVNAYVIDTGVRGSHGDFGGRVGTGVDLVDALPAADCNGHGTHLAGTVGGALHGVAKRVRLHPVRVLNCAGSGSVAQVIAGVDWVRANAVRPAVALMALGGTASAALDAAVTNSINAGVSYVVVAGSSNGDACSGSPARVPAALTVAGTTQTDARMPSGNYGSCLDLYAPGANITSTWHTTDTATTTLSGGSMAAAHVAGCVALALQTNPSWTPAQVAAYLIGRATVGVVSGVPSTTANRLLYCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6A9</accession>
    <name>F4F6A9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09685"/>
    <dbReference type="EnsemblBacteria" id="AEB43055">
        <property type="protein sequence ID" value="AEB43055"/>
        <property type="gene ID" value="VAB18032_09685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09685"/>
    <dbReference type="eggNOG" id="ENOG503146G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3085994_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="52" mass="5942" checksum="E560F432010325BF" modified="2011-06-28" version="1">MVRGFGPWLAVLALVLLLSALRLRTLAALVSVGWLIWCVWTWIRPGRRSNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6K2</accession>
    <name>F4F6K2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16120"/>
    <dbReference type="EnsemblBacteria" id="AEB44330">
        <property type="protein sequence ID" value="AEB44330"/>
        <property type="gene ID" value="VAB18032_16120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16120"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056518_0_0_11"/>
    <dbReference type="OMA" id="SEHEYAM"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="42"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="31985" checksum="BFE62F8403D89BC9" modified="2011-06-28" version="1">MRTDEAVRVATLAGARVGMPVDDAQVLRVGENGVVLLSGVGVLVRVVPRAGAVQRVRLEIAVAEWLASQGVPVARPVRSEPIVVDQHVVSLWEYLPGGHSADLVTLARCLRLLHGVPRPVGLLTRVSPFSRLREQLASAVGLDERDRAFLREFRDGLAVQWDHATFALGEAVLHGDAHMENLLVTTAGRCAFIDLESVCVGPPEWDLTLSALYYECGWFSEHEYAMFADSYGYDVRCSPAWPVLRQIRMLRMTLWLAQSADNDTPRRQQLRHRLDSLRDGSAPAGWTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6X2</accession>
    <name>F4F6X2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component transcriptional regulator, LuxR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734299.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22735"/>
    <dbReference type="EnsemblBacteria" id="AEB45647">
        <property type="protein sequence ID" value="AEB45647"/>
        <property type="gene ID" value="VAB18032_22735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22735"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="IARDSHW"/>
    <dbReference type="OrthoDB" id="1762314at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="20482" checksum="4C42F587A74B95E4" modified="2011-06-28" version="1">MIRTLLALDGALVRGALSLVLTAEADISVVAEVDRGDGLARLIRARRPDVAVIDLDLVGTANVAGWCPLLVLVDQRRARRLHRVLVPGRPLGILGRDVAPHRVLDGLRRLARGESVIDVDLVMAALTRGSPLTSRETQILDLTAAGAPVAEVARALGLAPGTVRNHLGRITRKVGARTRVEAVRVAHEAGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F729</accession>
    <name>F4F729_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735542.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29111"/>
    <dbReference type="EnsemblBacteria" id="AEB46893">
        <property type="protein sequence ID" value="AEB46893"/>
        <property type="gene ID" value="VAB18032_29111"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29111"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_4_11"/>
    <dbReference type="OMA" id="QRAYPVR"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="27207" checksum="37A96D6A3C811CEE" modified="2011-06-28" version="1">MPELVYPPVIAAAKTMFRVLDLRLTVQGSHHVPRTGGAVMASNHVSYLDFIFCGLGALESRRLVRFMAKESVFRHRVSGPLMRGMRHIPVDRGAGAESYAAALAALRAGEVVGVFPEATISRSFTVKELKSGATRMACEAAVPVLPVALWGTQRLWTKGRPRTLTRRHTPITILVGEPLHPAAYPDANAMSAELKTRLQDLVDRAQREYSDQPADDADRWWLPAHLGGTAPTPEEAAALDTADRRPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F779</accession>
    <name>F4F779_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10095"/>
    <dbReference type="EnsemblBacteria" id="AEB43137">
        <property type="protein sequence ID" value="AEB43137"/>
        <property type="gene ID" value="VAB18032_10095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10095"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1170267_0_0_11"/>
    <dbReference type="OrthoDB" id="1825883at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="25538" checksum="18947CA0B9ECFAA5" modified="2011-06-28" version="1">MHRACPPGRWIRRERGDGELILISAEVPCAWVVAEFLRLLRNGVLAYNRNKNQESQLRLRAGIDRGDVLVDDADIPRGGDAIVSAVRLQGCEAANEAAVAVPAAPVVAVISDEVYRATVRFRELGLEPELFRDVRVAVPQKDFVATGWLHLPGHVPPIVTAGYPEDDLPGPEPTRAKGPAGTTSSARVSDRASDHEEHRPPSGGKYQYNQHGSTGVITQGDGTHIDARGMNVYGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F782</accession>
    <name>F4F782_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRP/FNR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10110"/>
    <dbReference type="EnsemblBacteria" id="AEB43140">
        <property type="protein sequence ID" value="AEB43140"/>
        <property type="gene ID" value="VAB18032_10110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10110"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_0_11"/>
    <dbReference type="OMA" id="PLEICNI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="23424" checksum="813244E01FA3758E" modified="2011-06-28" version="1">MTRAGTQRSYSAGTVLLHQGDPSRHVLLIEKGWVKVTSTSRRGWEALLALRGPGDILGELSAVDGQPRLSTVTTLTGIEATILSAERFHACLAQWPEIALSLLRQVTASLREADGRRVEYGSSNGDDRLVVLLVELLDKHGVETSDGVLLDLPLTQQDLAAAVGASREVVARTLRVLRERRIAITQRRRIVIVRPDLLRSLAGSVSMSTQHLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7B8</accession>
    <name>F4F7B8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10290"/>
    <dbReference type="EnsemblBacteria" id="AEB43176">
        <property type="protein sequence ID" value="AEB43176"/>
        <property type="gene ID" value="VAB18032_10290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10290"/>
    <dbReference type="eggNOG" id="ENOG5033BK4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138477_0_0_11"/>
    <dbReference type="OMA" id="EHTTCAG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="12391" checksum="CA5F19282D3AFABA" modified="2011-06-28" version="1">MQPVPKEGATDRADAEHTTCAGAGMPLTARVLFAVVNAQGVLVRGLGAATANRLGTGMYQVVFDQDVTGASCVGTVGLSGSIGLAPTGQITVAGRTGIPNAVFVTTHDSAGVSADRPFHLAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7G0</accession>
    <name>F4F7G0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16465"/>
    <dbReference type="EnsemblBacteria" id="AEB44399">
        <property type="protein sequence ID" value="AEB44399"/>
        <property type="gene ID" value="VAB18032_16465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16465"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405387_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="592" mass="64420" checksum="FC06602FD6AEC428" modified="2011-06-28" version="1">MTLAHERADGRSLVSRHPDRPDLPLSLADAAGNRVDYSYDDGGRLLRAYSRAFDRDIETRTYHPDGSLASATDGRGATTGYHYDGRGRLVAIDPPEPLGQIRFAYDDDSRVVRVTHGNGQRVGFTYDASGRLVEVRDDDTGQVLGDFAHDSAGNLTHRSGPGWSESIQWRDGRRIGSVRREGREMEQVGYRHTASGALAAQLDLNGTTTYGYDAAGRLAVLDDPFGGRTSFEYDGAGRRTATVFAGGGSQRTEYDALGRPVRLVVADGRGDPVHTVSYDYGGGALLAARTVDGVTTEYAYDGLGRVVRAGDEEFGYDLANNLIRLGGTTFDVNDAGQHVRFGETVLGYDRSGNFVDEVNPTVRFTYSPTNQTRTGSVDGRQVVDIRYDGLDNREPRRIHETTLDGRSVTHVLHRTSLGIVRVTDDVPTAFVREPSGRLIGLRTADGTRYQAVTDHQGSVLALLATDGTLAATYTYSAFGAVTATSGVAAVNPFRYLGAYQLLRGAHFLECRIYNGAWGRFTQPDPRHQARAPYTFADNDPVNLGNPARTNFWATLSRPPREAVAAFHGTPPPPTTFLGTGIPFITRRGDDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7L8</accession>
    <name>F4F7L8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aha1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733114.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16765"/>
    <dbReference type="EnsemblBacteria" id="AEB44457">
        <property type="protein sequence ID" value="AEB44457"/>
        <property type="gene ID" value="VAB18032_16765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16765"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_0_0_11"/>
    <dbReference type="OMA" id="CDAPHLL"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="23388" checksum="87C25DB4101925F1" modified="2011-06-28" version="1">MIDIINQVNATHREIGNQAVAAGAGRSLLLRRVYDAPIEDVWSACTEPERLSRWLGPIEGDLRVGGTFQLKDNAGGEILRCEEPRLLKVTWVLGEGMSTEVEVRLAPGDDGRTVFELEHASPAEIVDELVRTYGPGGTIGIGGGWDLALLGLDLFLHGVNVDPATWEDTPEAKEFAIRSCQAWAPAIQAAWGTSDDDIAAAIAFAVQHYAPDTRGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7T3</accession>
    <name>F4F7T3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734372.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23100"/>
    <dbReference type="EnsemblBacteria" id="AEB45720">
        <property type="protein sequence ID" value="AEB45720"/>
        <property type="gene ID" value="VAB18032_23100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23100"/>
    <dbReference type="eggNOG" id="COG5502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112438_0_0_11"/>
    <dbReference type="OMA" id="EGWDPTG"/>
    <dbReference type="OrthoDB" id="1639031at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="142" mass="16462" checksum="12B10251E4F7A22B" modified="2011-06-28" version="1">MAEQFQSAIESSVDKTNLILKDIEQAYGWPKAQRNQSYAALRTVLHLLRDRMPVQESVEFSAQLPMLVRGIYFDGWQPENVPIKLNRDDFLYEVRQGFPYDAEGGPQRVVQVVLETLRRHITQGEWDDVRATMPDDLVQIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F841</accession>
    <name>F4F841_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04535"/>
    <dbReference type="EnsemblBacteria" id="AEB42033">
        <property type="protein sequence ID" value="AEB42033"/>
        <property type="gene ID" value="VAB18032_04535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04535"/>
    <dbReference type="HOGENOM" id="CLU_2738926_0_0_11"/>
    <dbReference type="OrthoDB" id="2176897at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="71" mass="7573" checksum="C6160500760AE472" modified="2011-06-28" version="1">MAGWPTYCARCGGPAIALIEAGHPGTGHYRAEVTCTRHHPAAIRWASHVGPARTTPIGDQPALFDLPEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F860</accession>
    <name>F4F860_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10515"/>
    <dbReference type="EnsemblBacteria" id="AEB43221">
        <property type="protein sequence ID" value="AEB43221"/>
        <property type="gene ID" value="VAB18032_10515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10515"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="YALELCP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="250" mass="26682" checksum="26FEF05B4897207A" modified="2011-06-28" version="1">MASTAPSLDVRGVRYAYPDGHVALHGVDLTVARGERVALLGPNGAGKTTLVLHLNGILSATEGSVSVGGLPVTGDRARLAEIRRRVGIVFQDPDDQLFLPTVAEDVAFGPANLGLRGAELAARVDEALAAVGMSEHRDRAPHHLSFGQRRRVAVATVLAMHPEILVLDEPSSNLDPAARRELATILRALPVTLLMVTHDLPYAFELCDRSVILDGGRIVADGPTADLLGDTDLLARHRLELPYPFSPARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F881</accession>
    <name>F4F881_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Erfk/ybis/ycfs/ynhg family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_10620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10620"/>
    <dbReference type="EnsemblBacteria" id="AEB43242">
        <property type="protein sequence ID" value="AEB43242"/>
        <property type="gene ID" value="VAB18032_10620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10620"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039404_3_1_11"/>
    <dbReference type="OMA" id="KFKETRM"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="203"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="357" mass="38610" checksum="A2E144FC10A423B1" modified="2011-06-28" version="1">MSPADGAKDRPVSAEIGAKLPDGGKVTQVTLTTDNGKKVKGKLRTDGSSWVPSAPLKWSTTYTATVTATQPDGSVSEGTSTFTTMTKPASVINSGLYLFDDRTYGVAMPVVAEFHPGIAKKDRAKVQKRMFVQTDPPQPGAWHWVGNGTQAYYRAPEFWKPGTKISVRIALAGIPLSNGRYGNVDRTATAKIGSAFEMKVTNSDKQMRVYENGKLIKTLPVSLGKTKTPSSSGTLVVMEKKEATVFDTMDDPDPENRYVTDIQFAQRLTWGGEYIHAAPWSEHVQGRQNVSHGCVNVSMANARWLFERTKIGDPITITGTERKLAAGNGWTAWDLSWAEFVKGSALPVPDGGAGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8H2</accession>
    <name>F4F8H2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733172.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17065"/>
    <dbReference type="EnsemblBacteria" id="AEB44517">
        <property type="protein sequence ID" value="AEB44517"/>
        <property type="gene ID" value="VAB18032_17065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17065"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137417_0_0_11"/>
    <dbReference type="OMA" id="KWIMAVD"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="14857" checksum="F942EEC21888BCE3" modified="2011-06-28" version="1">MTQTDVSNLSLELTDDPETQNAVFLAAFNSGRGDLFDLLYRSDAISNLSGQPLTGAARTEAITKLLATGPKLHSVVRDSVVAGDTSLIIVGFELEVTAADGTRQRITGRCTDVLVREPDGKWIMAVDRPVAEHTETLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8I2</accession>
    <name>F4F8I2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733182.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17115"/>
    <dbReference type="EnsemblBacteria" id="AEB44527">
        <property type="protein sequence ID" value="AEB44527"/>
        <property type="gene ID" value="VAB18032_17115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17115"/>
    <dbReference type="eggNOG" id="COG1694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144839_1_0_11"/>
    <dbReference type="OMA" id="ENGRDAH"/>
    <dbReference type="OrthoDB" id="1978527at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11533">
        <property type="entry name" value="NTP-PPase_Af0060_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044548">
        <property type="entry name" value="AF0060_NTP-PPase_MazG-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="109" mass="11488" checksum="48731818088B848A" modified="2011-06-28" version="1">MTDLFDLAAVVTARLDAVNGRSREEIGLRILKVTEEAGEVAAAWIGAIGQNPRKGVTHTTDDVAAELADVALTALVAITSLDRDPRDVVTACVNKAAARLDTYSTTPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F907</accession>
    <name>F4F907_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735734.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00015"/>
    <dbReference type="EnsemblBacteria" id="AEB47087">
        <property type="protein sequence ID" value="AEB47087"/>
        <property type="gene ID" value="VAB18032_00015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00015"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155928_0_0_11"/>
    <dbReference type="OMA" id="MSCGEPH"/>
    <dbReference type="OrthoDB" id="2036019at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="95" mass="10982" checksum="760BFBD499936E00" modified="2011-06-28" version="1">MSCGDPHETDCREVLAEVYLYLDLECAQERRTLIRHHLDECGPCLREYGIEQEVKALVARCCGNESAPDELRERLRVRISELVIFESTESRELAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9B8</accession>
    <name>F4F9B8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731983.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10970"/>
    <dbReference type="EnsemblBacteria" id="AEB43312">
        <property type="protein sequence ID" value="AEB43312"/>
        <property type="gene ID" value="VAB18032_10970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10970"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076820_0_0_11"/>
    <dbReference type="OMA" id="VGATNQK"/>
    <dbReference type="OrthoDB" id="1824113at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="223" mass="23143" checksum="B44D733A45B3E868" modified="2011-06-28" version="1">MVIPLPRPTAVVGLTRSALDSAASFAAIPARAFAVLDGVEALLTRINGVVDRIEQTLDRTDQVLADAEVAVREVAVISAAATVAVDNAGTVAAAAADVVARAEKVSGQAAETVGAAAEATATAAELLAAYEPALRRAAPMATHFIEQLSHEEVAAAVRLVDELPKLRQHLTADVMPILATLDRVGPDLHDLLDVTRDLKLAVAGIPGLAMLRRRGEKLNDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9C5</accession>
    <name>F4F9C5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_11005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731990.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11005"/>
    <dbReference type="EnsemblBacteria" id="AEB43319">
        <property type="protein sequence ID" value="AEB43319"/>
        <property type="gene ID" value="VAB18032_11005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11005"/>
    <dbReference type="eggNOG" id="ENOG5033DSM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150487_0_1_11"/>
    <dbReference type="OMA" id="ATITLCW"/>
    <dbReference type="OrthoDB" id="2046887at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="100" mass="10306" checksum="9D93DBEB76EEACE9" modified="2011-06-28" version="1">MTAVRDPGLQPERTRLAWRRTMLAVTVVTILAVRLGLTGGRVGALLTALAILGWGATITLCWRRAVGSGVPDTSVRTLSAVGLCVAGLALIGVVLVVCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9G4</accession>
    <name>F4F9G4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvH</name>
        <name evidence="10" type="ordered locus">VAB18032_11200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732029.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11200"/>
    <dbReference type="EnsemblBacteria" id="AEB43358">
        <property type="protein sequence ID" value="AEB43358"/>
        <property type="gene ID" value="VAB18032_11200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11200"/>
    <dbReference type="eggNOG" id="COG0440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_1_3_11"/>
    <dbReference type="OMA" id="EPYGIKE"/>
    <dbReference type="OrthoDB" id="1500398at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="171" mass="18334" checksum="2276E4A401E08DD1" modified="2011-06-28" version="1">MTMHTLSVLVENKPGVLARVSGLFSRRGFNIDSLAVGETENPDVSRITIVVNADSSPLEQVTKQLNKLVNVLKIVELDPSTSVARELLLVKVRADRNARGQVLETVSLFRARVVDVAADTLTIEATGTPDKLDALLRDLEPFGIKEMVQSGLVAIGRGPRAITAGPALRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9P0</accession>
    <name>F4F9P0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733273.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17580"/>
    <dbReference type="EnsemblBacteria" id="AEB44618">
        <property type="protein sequence ID" value="AEB44618"/>
        <property type="gene ID" value="VAB18032_17580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17580"/>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101336_0_0_11"/>
    <dbReference type="OMA" id="DVFNDGC"/>
    <dbReference type="OrthoDB" id="1639765at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="44"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="197" mass="21414" checksum="FEF4A08EF63F80A3" modified="2011-06-28" version="1">MENSVAVRHRSMDEIMAGLHLVRQSPRAAGTLALAVRRPAVDAREVLSEAELDASVGLLGDSWGQRPSKRTPDRSPHPDMQLNVINSRFIELIAGADRDAWALAGDQLYVDLDLSVEALPAGTRLAIGDRAVIEVTDQPHNGCAKFAARFGRDAHKVVWTEEGQRLRLRGLNARVVVGATIRVGDAIRQLPPGQLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9P7</accession>
    <name>F4F9P7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arsenical pump membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_23625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734475.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23625"/>
    <dbReference type="EnsemblBacteria" id="AEB45823">
        <property type="protein sequence ID" value="AEB45823"/>
        <property type="gene ID" value="VAB18032_23625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23625"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043931_0_0_11"/>
    <dbReference type="OMA" id="AMTTVWL"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="403" mass="41847" checksum="706F4327C5D7C0B6" modified="2011-06-28" version="1">MTAIGDAPTPPGRRPHPLDVIAVGLALAGAACVATGLLPRADAAATLARILPLLIFLGTVVVLAELTAAAGVFDVLATRMARAARGRWPALFALCVGFAALTTIVLNLDTTAVLLTPVMLALAVTLRTAVAPLAVTTVWLANTASLLLPVSNLTNLLASERIGLDPLAYLGVMWLPQLAAIAVTTVLLWWFWWRRDQPPGGRFPPPPTHRPTDAVLYRTALVACLIFVAAILLGAPVGLASAVATGLLLLGFAIRSPGTLRPALLPWRLLVFVTGLFLVIQTIGVHGLNDLVAWLAGDEGGTSGVLRAGGTGALLANLVNNLPAYLAGEAVLPTGDRQRLLALLVGTNVGPLALPWASLATLLWLERCRAARVRVPLARFLLTSTVLAVLGTLAAVGALLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9V5</accession>
    <name>F4F9V5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734533.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23915"/>
    <dbReference type="EnsemblBacteria" id="AEB45881">
        <property type="protein sequence ID" value="AEB45881"/>
        <property type="gene ID" value="VAB18032_23915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23915"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079038_0_0_11"/>
    <dbReference type="OMA" id="PPRRYDM"/>
    <dbReference type="OrthoDB" id="1110576at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="307" mass="32944" checksum="940A08AC7E3567E5" modified="2011-06-28" version="1">MTTEWTVVAAAEQFTLDARNAGELTFTVSNPGLAPDTVVFDVAPGEGSQRAWFTVTEPQRTVPPQGSVSFLVRLAVPPGTPPRRYDMTGFAYSANTAPEESSRSSGRVTYEVRAVAPPKRTPWPWIAAAAALVLLVSATVVFLVTRGEDPPPSPPRVVTIEAETLVPTAQVGSPSNSAASVLAQGNCCQVAWSQDAQLFFLGRAINDRVTVRVELPAEATWQFSAVLTTAPDYANTVFLIDGRQVGDPFIGFTPKVQITDWLDVARVHLSAGPHDITLVAIGKTQSTDSYFAGIDTLRFTELPPPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA06</accession>
    <name>F4FA06_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00165"/>
    <dbReference type="EnsemblBacteria" id="AEB47117">
        <property type="protein sequence ID" value="AEB47117"/>
        <property type="gene ID" value="VAB18032_00165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00165"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054560_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313712" evidence="1">
        <location>
            <begin position="21"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="39"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="366" mass="40206" checksum="04D50CBB2F8A1E74" modified="2011-06-28" version="1">MALIAALLLAPMVAPGVANANGPFVPPGQETLNRSSILSAAEVSAEMHALAARSKGALRIEEIGRSGRGRPLEIAFIGTGETRVWIQGRIHGNEPYGAEASLDFLKTLVSGGKKTQEVLKNISFAIIPIYNPDGFEEYRRQDSVHRIDLNRDWGVDRQIFDQINSVRASRGEAPLPERNFTNYTQYRAVESQQFWYAWADFKPHHMIDLHHQGTYYVGDDTDEMTTFSVGISLDPGMLTQSQWDTVRRMGVAAADAANKSGVVETTLYPYINIPEGVVSAAMLNGPGPRGEYANWRSNAMFFESRGGIGQKSGGYLIKQNVNGLWGIINAMSDGSLANVDADRYNELPARGATITTCIKFPNQCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA17</accession>
    <name>F4FA17_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_00220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00220"/>
    <dbReference type="EnsemblBacteria" id="AEB47128">
        <property type="protein sequence ID" value="AEB47128"/>
        <property type="gene ID" value="VAB18032_00220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00220"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004900_0_0_11"/>
    <dbReference type="OMA" id="HPYRWWG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="12">
        <location>
            <begin position="78"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="13">
        <location>
            <begin position="390"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="786"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB47128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1190" mass="126222" checksum="DC5E31C2D17565A8" modified="2011-06-28" version="1">MQAYRLVRRPVGPTEGDGPTDGRSPAQALPVADPPSTAPAPASPPASEGSPGEQIGPARVTGPQGDPAVTGLRGGLGWVADAGQAEVVAHTDGPMLVLGGPGTGKTSTLVEAVASRVAEGVDPERILVLTFSRRGAADLRHRIEARIAADGQRVLREPLVRTFPAYAFGLLRRAAAERGEPSPRLLTGPEQDLIIRELLDVVGEESGDDPVGWPEDLRPALRTRAFAAQLRDLLMRAAERGVGPVELARLGEKLGRADWPAAARFLREYVAVLALRDVANRGSVAYDPAELVRAATGMLRDDPELLAVERRRLAYVYVDELADTDPAQRDLLETVAGGGLTLVAFADPDSSTYAFRGADPTGVTTFPHRFRTASGAPAAQVLLTTSYRCGERLLAASARLARRLRGPAAHRRMRPVPGTPPGSMEIHTFRSATSEAAWLAHALREAHLLGGLPWARMAVLVRSTGRQLPTLRRALHAAGVPTVVHGEDLPLHLQPAVAPLLLLLRCALEPDRLDEEAAVALLHSPLGGADPLAERRLRQGLRALALAAGDRRPSGELIVEALRDPAELAGVERRWAEPAQTVAGLLAVARETAARPGATAEDVLWAVWRASGLAELWSAALTRGPSVAGEGDLARRRRAEAADRDLDAVMVLFDAAARFTDRLPGARTEVFLDHVLGQELPADTLAPTADRGDAVRLLTAHAAKGLEWDLVAVAGVQEGVWPDLRLRGSLLGSERLVDVLAGRADGAGTVATLVGQTSALLDEERRLFHVAVTRARRRLLVSAVASASVGGDDHDEQPSRFLYELGPGDTPTDEAPTASGDPEPLPAGIETSGTEPPGSETSTSEAGGSRTLPVSRPPRALTLPALVAELRTALVDPAAPLARRQAAAAELARLGAAGVSGAHPDDWWGLRPLSDDRPLVDEGEPVRVTPSGMESALRCSLRWLLERHGGSTPASAAQGVGNLVHAAAMLAEDARADRSALLEYVAARFDAIELAARWMVGPERARAEAMVDKLLRWLAANPRRLLAIEHEFAVRLDDPHRPVDLVGRVDRLEVDEDGRLVVIDLKTGKSTTVTEREVVEHPQLGAYQAAVEAGAFAEFGDESGGAALVQLGTGARDAREQSQPPATDGPEAGWATALVRRTADTMAASTFAAVANSKCRVCPVRTSCPVSGQGRQVVEPPTIRRPEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAE6</accession>
    <name>F4FAE6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase S1 and S6, chymotrypsin/Hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732044.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11275"/>
    <dbReference type="MEROPS" id="S01.494"/>
    <dbReference type="EnsemblBacteria" id="AEB43373">
        <property type="protein sequence ID" value="AEB43373"/>
        <property type="gene ID" value="VAB18032_11275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11275"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_3_5_11"/>
    <dbReference type="OMA" id="RTYPAND"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="27818" checksum="8FD739B9EFA86DFD" modified="2011-06-28" version="1">MAVQTGLGEPRGPWFVSPEFDPYGGDGTGQAAGTRDGAAWGWRRRLMAGLAVLALSTGSGAVAGGWVASRGIPEPAAASAAPVPAELVTAAEKTVPGVVSVLVGGATGSGFAVDSEQHIITNDHILAKGRGGPVTVELPDGRRFGAEVVGREPGSDLAVLKVPASAGLASLPLAKPGSTRVGEPVLAVGSPLGLSGTVTAGIVSALDRQVRLGDNRHRAVQTDASINPGNSGGPLVNARGEVVGVNTAIATIDGNGSIGIGFAIPIEQVQQTADTIIGKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAF1</accession>
    <name>F4FAF1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11300"/>
    <dbReference type="EnsemblBacteria" id="AEB43378">
        <property type="protein sequence ID" value="AEB43378"/>
        <property type="gene ID" value="VAB18032_11300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11300"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631478_0_0_11"/>
    <dbReference type="OMA" id="DCATATW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="353" mass="37107" checksum="838F1E7D1642B434" modified="2011-06-28" version="1">MVAPASTPQPGYRIEVRNAGNAPVDTTVRQELPQGVSATAISDGGRQVRPGGSTATEVTWRVKLPPRSTTTLDTTLTSTAAQQPVTAPACAFAVDGRQPYDCATATWTAPGATAAAPSTQTSGWRGQVPALLAGAAVLLALAVVGFVTWRRRRPPVAAALASDGPGRIYPRPAAPRPTTRRRTPPVWLIVPVAATVLAATLGTAAWTATRRVAAIDTDSQPTNGAWKGSGVSGGLGVPLREDAFEFTVYRMTCDPGQGARQCQATVGVRNLAPEHHSWHGKLQRAYLANGNWVTTDEQATRRANQGRDVFAEPMAAGSRLVLPLVFTVNGDEAPQRLELRSGVFSAGVRVDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAP0</accession>
    <name>F4FAP0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733310.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17765"/>
    <dbReference type="EnsemblBacteria" id="AEB44655">
        <property type="protein sequence ID" value="AEB44655"/>
        <property type="gene ID" value="VAB18032_17765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17765"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OMA" id="DWMGQWT"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="343"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="227"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="545" mass="59220" checksum="406ED33259F4E3CB" modified="2011-06-28" version="1">MSDSFVVCSNLSFSWPDDTPVFQDLSFTIGAGRTGLVAPNGAGKSTLLRLLAGEYRPTAGSVSTQGVLGYLPQTLPLVGDRTVAEVLEIAPLIGALHAIESGDADEEHFTTIGNDWDIEERTRAQLDRLGLGDLAFDRRLDTLSGGQVVSLGLAAQLLKRPDVLLLDEPTNNLDIEARHKLAEVLEQWTGCLLLVSHDRALLDRMDRIAELDRGDLRFYGGNFTAYEAAVRAAQEVAEKNVRNAEQELKREKRELQEARERAARRAGNASRNLKNAGLPKIFAGTLKRNAQESAGRADELHSARVSEAKARLDEAGQALRNEQKLSLELPGTQVPAGRTLLAAERMQVRYGGRPVFADDGVDLTIRGPERIALLGANGAGKSTLLRLVTGTLEPEGGQIRRADGRIAYLSQRLDLLDPERTVAENLAVFAPQAPEARRMHLLARFLFRGARAQLPVGVLSGGERLRATLACVLGAEPAPQLLLLDEPTNNLDLVSVGQLESALNAYRGALLVVSHDERFLAEIKVSRWLRLAEGRLLETGPPPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAR1</accession>
    <name>F4FAR1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter atpase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17870"/>
    <dbReference type="EnsemblBacteria" id="AEB44676">
        <property type="protein sequence ID" value="AEB44676"/>
        <property type="gene ID" value="VAB18032_17870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17870"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="KGFENHW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="31212" checksum="E39DA79DBF148DC0" modified="2011-06-28" version="1">MTPHSTRTAAPTGRSSSTGRGGAPVSLRDVDIRFGDFDAVRGATLDIAAGEFVCLLGPSGCGKSTLLNAVAGFVTPAGGEVTCGNAPVTGPDVSRGVVFQSAEALFPWLSVRQNVSFGPRMRRMPKAQRAAVEDRYLAMVGLSHSADKFPSQLSGGMRQRAQLARVLANEPSVVLMDEPFGALDAQTRLVMQVELDRIWRDTGATILFVTHDIGEAILLSDRIVTMTAGPAAAIKNVYPCDLPRPRDLTDPASAALFRQLREDIGEEVARTLRAQGLDDGHDGRSTGDQKGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAW8</accession>
    <name>F4FAW8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short-chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734583.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24165"/>
    <dbReference type="EnsemblBacteria" id="AEB45931">
        <property type="protein sequence ID" value="AEB45931"/>
        <property type="gene ID" value="VAB18032_24165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24165"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_11"/>
    <dbReference type="OMA" id="SVCCNRW"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="33733" checksum="9C4D3A549ED72344" modified="2011-06-28" version="1">MTAHTRVSIPFTARATATEVLDGVDLTGRRMIVTGGASGIGTETVRALAGAGAEVTVATRNPATADELVAEFAGSGPGTVRAAGLDLADLASVDAFVAAWEGPLHALVANAGVMAIPTRQLTPQGWELQLGTNYLGHFALARGLHDNLRVAGSARVVVVSSGAHLREAFDFDDPQFERQPYDRWAAYGRSKTAEVLLAVGIARRWATDGITANALNPGFITTNLQRHMDDETLRAFGAMDEAGNRIEQPYFKTPAQGAATSVLLAASPLVEGVTGRYFDDNQEADVVAGGPEATGGVAAHAVDPAAADRLWAYASQALASLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB47</accession>
    <name>F4FB47_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735837.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00540"/>
    <dbReference type="EnsemblBacteria" id="AEB47192">
        <property type="protein sequence ID" value="AEB47192"/>
        <property type="gene ID" value="VAB18032_00540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00540"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049717_1_0_11"/>
    <dbReference type="OMA" id="IGHQWAY"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="319" mass="34305" checksum="8EB398805497CFAF" modified="2011-06-28" version="1">MATSAHLIVGAGLVGSTTARQLAEQGEQVRIVSRSGRGPDHPRIERFAADAVDADRLSELADGATAIYNCLNPAYHRWLTDWPPMADALLTAAERSGAPLVVTGCLYGYGEVTGAMTEQTPLAATHPKLKVRADMWRAALAAQRAGRIRAVTEVRGSDYLQAQSIFSFLLGKPLLAGRRAFVPGPLDVPHTWTSINDMAAMLITAATDQRAWNRAWHVPSAAPLTIRELATRFTEVVGAPAPKLTTIPGPVFRAAGLLSAMLREFQTTAYQFDRPFVMDSTAATETFGLRHQPLDESLRETAALLGGLPAATTRRPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBE3</accession>
    <name>F4FBE3_MICM1</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05565"/>
    <dbReference type="EnsemblBacteria" id="AEB42239">
        <property type="protein sequence ID" value="AEB42239"/>
        <property type="gene ID" value="VAB18032_05565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05565"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071262_0_0_11"/>
    <dbReference type="OMA" id="DEIVWDM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307593" evidence="2">
        <location>
            <begin position="48"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="33922" checksum="3D61B68D0412A197" modified="2011-06-28" version="1">MLTRAANHLDRASVDPRLLRRTAVRRLLLGTALALLLVTGPAVPAGAADPGAECPPAQPNCNVWDDDPGTPGGGGNGGDNGGDNGGGGGGSSVCRWKGQTVPCYREGMGWFNSQDGCYYRLSEPQLEAPPGWQWYTLTCDAVSLGSVRNELLEGPPPGFGAPPDPEELARRAFASITLLAPRAAVAPRKDIGPGLVGLPVWMWASRGATYFGPQSASASDRGLTVTIQAEVDEIVWDMGNGHRVVCDGPGTAYDRRGQHAGKRSPDCGYHNGYSKAGTYRVQATTHWSVTWTSSSGATGSIGGVTRTTGPVQIQINELQVVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBH8</accession>
    <name>F4FBH8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M23B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11630"/>
    <dbReference type="EnsemblBacteria" id="AEB43440">
        <property type="protein sequence ID" value="AEB43440"/>
        <property type="gene ID" value="VAB18032_11630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11630"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077601_4_1_11"/>
    <dbReference type="OMA" id="TTCLHWG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="56"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="205" mass="21228" checksum="5CF4043B1EE53B59" modified="2011-06-28" version="1">MSLAADHQGLVVSASALVPPSRVVAADSVGRYRWPVDGQPRPVRRFDPPPRPWLAGHRGVDLLAPAGATIRAAGDGTISYAGMVAGRPVISVAHADGLRTTYEPVEPAVTVGTSVHAGTVLGVLLPGHAGCPQAACLHWGLRRGDDYLDPLALLGLGRTRLLPLADAPLSAGRAGWAVARRAGRTRRASCTPGRTVSASPARPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBL1</accession>
    <name>F4FBL1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_11795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732142.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11795"/>
    <dbReference type="EnsemblBacteria" id="AEB43473">
        <property type="protein sequence ID" value="AEB43473"/>
        <property type="gene ID" value="VAB18032_11795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11795"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_11"/>
    <dbReference type="OMA" id="HMAHHDG"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="308"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="451"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="711" mass="77521" checksum="A31FAA9622ADE565" modified="2011-06-28" version="1">MSAVGAPGGRAVDPAGAHNYATEWAQAVRRLGFVPMSAADTERLLLSYTLRLAEALLHADEVAPVAAEVGQALVEAHLTEPDMIEWSVRSLADRLPDQVLGGSTGLDDRIAVAQGALAAGFARALRDRTFAQQERIARSAWQARDDVERALRDSEARFRAVFRGAAIGIGIADVDGQIIDVNQPFADMLGYSIEEMRQLNVTALFHHDDAPGMWELYGELIEGKHESARVEKRYYRKDGTSVWTDLAVSLIRHDDGRPRFTIAVAEDITQRYELQRRLRFQALHDPLTELPNRTLFFETLSRLLSASGRVGVCFLDLDGFKAINDSLGHDVGDRLLMTIARRLAGCVAEYGYLVARMGGDEFVILVDGDAGVDNMIAVAELALTAVSAPVFIDDHQLMVSASVGIVASDLVGTSAAELMKAADTTLYWAKAEGRGRWAVYDPERSARDIARSTLLAGLPVALDRDEFVLHYQPIVSLLDGRMLAVEALVRWQHPELGLIGPDRFIGLAEETGLIVRLGEWVLRQACRDARRWHVDFPEARLVVSVNLAARQADAPVIVDTVADALSSSGLPAELLQLELTESAVMGSGGEPLRTLYRLAELGVRLAVDDFGTGYSNLAYLRRLPITCLKLAAPFVEGIRGDEPDAADHRDERIVDALVRLAHALELWVTAEAVETEPQAERLRALRCDSAQGRLFGPPAPAAAISTRLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBU2</accession>
    <name>F4FBU2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733397.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18200"/>
    <dbReference type="EnsemblBacteria" id="AEB44742">
        <property type="protein sequence ID" value="AEB44742"/>
        <property type="gene ID" value="VAB18032_18200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18200"/>
    <dbReference type="eggNOG" id="COG3618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044590_2_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="152"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="279" mass="29732" checksum="94D3FB5133BE8A89" modified="2011-06-28" version="1">MDLADAHLHLFANGYPGRYGRSPAGAEELAAYQDIRRVHGIDRALVVGYEGEEHFAGNNDYLASLVGSHPWIAPVAYVSPDGPADGQLARWWAAGFVGVSAYLADTEQADRFAAWLTTAVPQLTAARALLSLNATPAATARLGTALAGLDACPVLFSHLGLPGSRPTPPTPQQAAETLAPLLDLARLPQVGVKVSGLYAVSEPAHAWPHSAARPFVDLLLERFGSRRLYWGSDFPPSLDHVSFSQTLEPVGLAQLSRTEQADIFGANLRRALDGVQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBY1</accession>
    <name>F4FBY1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733436.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18395"/>
    <dbReference type="EnsemblBacteria" id="AEB44781">
        <property type="protein sequence ID" value="AEB44781"/>
        <property type="gene ID" value="VAB18032_18395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18395"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OMA" id="RIVWAIC"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="473" mass="47207" checksum="19AF35972788A242" modified="2011-06-28" version="1">MVENFSGASTARLGARQWLAIGALGASFLVVAADSTIVYAAIPSIQRALDLSTATVQWLMSAFLISFGGVLLLSSRLAELFGRRRLFTIGLALMTAASMLSAVAWAGEVLIGARVLQGIGAALIATTALPLLAIALGPGPARVRALGLWTLIGAFGGTTGLLLGGLLTDTVGWRWVFLVNVPVGIVAALLAPILPADRCGGSGHPLEVAGGVSLVGALTLIGWTVVAAFAPGSSTGPALLRLAAAAVLLLLFLVIEARTGRRLVRPGLLRSRTRLGGLVVLFAAGTLIDAVLLLVTLYGQGALGLSATRFGALMVALTLSSVVGSYVGQVVVVRHGLRLVALTGMSVAGAGLLALAMVNGPLDTVDFLSVLPVVGVGAGAAFVAAQIAVTLGASDADSAAASGLSDASFSLGGALGLAAVSAVLVANQTELPVPMGAALPMAFTVTAGLAAIGLVAALLLMGQQRTPVPSQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC28</accession>
    <name>F4FC28_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734678.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24640"/>
    <dbReference type="EnsemblBacteria" id="AEB46026">
        <property type="protein sequence ID" value="AEB46026"/>
        <property type="gene ID" value="VAB18032_24640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24640"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_35_0_11"/>
    <dbReference type="OMA" id="HLDWERM"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="291" mass="32934" checksum="6095FEEC1D30B14B" modified="2011-06-28" version="1">MQGSQKVRHRQADVDGVTVFYREAGRPGRPTVLLLHGFPSSSHTFRQVMPIIGDAAHVIAPDLPGFGMSSSPTVGDYDYTFDNLSRTVERLLDQLGVERFFVYLHDFGAPVGYHLATRAPARIRGLIVQSGNAHDDGLGEQWDSARAYWAEPTDERRAALPDWLNFAGTRDQYLAGLPEHVRILHAPESWHLDWERMSRPGNIDAQFALFTDYANHVARFAEIAEYHRAHQPPALVLWGRHDPYFDVVEVLAYHRALDRMDAHLYDGGHLLLETHAIECADLMRTFVLDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC41</accession>
    <name>F4FC41_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734691.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24705"/>
    <dbReference type="EnsemblBacteria" id="AEB46039">
        <property type="protein sequence ID" value="AEB46039"/>
        <property type="gene ID" value="VAB18032_24705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24705"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083329_0_0_11"/>
    <dbReference type="OMA" id="PHESAYV"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="30896" checksum="242E46DC1FDDB288" modified="2011-06-28" version="1">MRVRERTGLLDVPGAQLYHEVRGEGPGLVIVPTGNGDATPMRPLATSLADQGFTVVTYDRRGFSRSPIDLPFDVDRRPDDDADDIGRLIEHLDLAGAHVFGGSSGAIVALGTLQRVPEQVGTVVAHEPPLATALPDAEEWLAFYTDLYDRYRREGAAAAQRHFRATMGMTASTRPPPEVELPGPQLAELLDRLRRNQDFWFEYEIRTYPSVVCDLKVLRANASRLVLAGGTDSRSTWPYRPGLALAEQLDASITHFPGGHVGYVTHPFAFADRLAEVLAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCB7</accession>
    <name>F4FCB7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">secY</name>
        <name evidence="13" type="ordered locus">VAB18032_01060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735937.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01060"/>
    <dbReference type="EnsemblBacteria" id="AEB47296">
        <property type="protein sequence ID" value="AEB47296"/>
        <property type="gene ID" value="VAB18032_01060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01060"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_0_11"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="441" mass="48889" checksum="9BEC597CEC100F5A" modified="2011-06-28" version="1">MLSAFLSAFRTPDLRKKLLFTVGIIAIYRLGATLPSPGVSYGNVQKCLDTIEGSTGVLNLLDLFSGGALLQLSVFALGIMPYITASIILQLLTVVIPRLEQLRKEGQAGQAKITQYTRYLTLGLGVLQASAFVALARSGQLFNNQCDEFPIIPQGTGIPDWLTLSILVMTMTAGTGVVMWLGELITDRGVGNGMSVLIFTSIAARLPSEGWRIKESQGWFKFFLVIALVLVVITAVTFIEQAQRRIPVQYAKRMIGRRMYGGTSTYIPLKVNQAGVIPVIFGSSLLYLPQLALQFFDQNDPGKTQAWIQNNLVDPTSPIYISVYFLLIIFFTYFYVSITFNPTEVADNMKKYGGFVPGIRPGKPTADYLDFILSRITLPGALYLAIISILPNFFFIWLDRQQYLNFPFGGTAVLIMVGVALETSKQIESQLMQRNYEGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCI2</accession>
    <name>F4FCI2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiA</name>
        <name evidence="5" type="ordered locus">VAB18032_05915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05915"/>
    <dbReference type="EnsemblBacteria" id="AEB42309">
        <property type="protein sequence ID" value="AEB42309"/>
        <property type="gene ID" value="VAB18032_05915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05915"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_5_1_11"/>
    <dbReference type="OMA" id="MVVYPYG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="27549" checksum="15A3828E76BCE68B" modified="2011-06-28" version="1">MRWGDLALITVAMVGARTFAMAANRILDRRIDARNPRTVNRELVTGAVSLRTAWTGAGVALAFFLAAAALLNPLCLVLAPLAVVPLIVYPYGKRFTNWPHAILGIAQMVGPIGAWLAVTGTFAGSGPAWVLGAAVGLWIGGFDLIYACQDAEVDRKIGVHSVPARYGLRFALHASTVAHVVTFALLLWFGALVGLGWLWWIGLALTALAFGYQHLVVKPDDLSKVNRAFFTANGFVSIALFVFALLDLVTRLDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDA9</accession>
    <name>F4FDA9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734791.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25205"/>
    <dbReference type="EnsemblBacteria" id="AEB46139">
        <property type="protein sequence ID" value="AEB46139"/>
        <property type="gene ID" value="VAB18032_25205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25205"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_5_5_11"/>
    <dbReference type="OMA" id="SEFCVDT"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="19868" checksum="F37D7DCC51CE9ABE" modified="2011-06-28" version="1">MSTLENRPHTALLVIDVQKGVVAGATRRDEVVANIAVLVDRARRESVPVIWVQHSDNGLARGSDDWHIVPELERADTEPLVEKSYADSFEATDLETVLSGLGVGRLVVTGAQTDVCIRSTLHGALVRGYDATLVSDAHTTEDLTAWGAPPPEQVIAHTNLYWAHHSAPGRTAGTVATADVTFTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDC2</accession>
    <name>F4FDC2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein VAB18032_01245</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735970.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01245"/>
    <dbReference type="EnsemblBacteria" id="AEB47333">
        <property type="protein sequence ID" value="AEB47333"/>
        <property type="gene ID" value="VAB18032_01245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01245"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116276_0_0_11"/>
    <dbReference type="OMA" id="MITTRAE"/>
    <dbReference type="OrthoDB" id="1380653at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="148" mass="16095" checksum="E0DE7B5C9A0D1117" modified="2011-06-28" version="1">MSLDQSFVGRTYPPTAPYQVGREKIREFARAIGATDAAYHDPEAARALGHPDVVAPPTFPIVLTMAANQQMIEDPDLAIDYTRVVHGDQRFAYTRPVVAGDELVCVNAIEEITGRAGHVFVTSRTEVTTTAGEPVVTAWMKLVVRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDE3</accession>
    <name>F4FDE3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_01350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735990.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47354">
        <property type="protein sequence ID" value="AEB47354"/>
        <property type="gene ID" value="VAB18032_01350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01350"/>
    <dbReference type="eggNOG" id="COG0435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_1_3_11"/>
    <dbReference type="OMA" id="PWANRAI"/>
    <dbReference type="OrthoDB" id="780709at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="165"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="348" mass="39170" checksum="A87D0E279AA69B95" modified="2011-06-28" version="1">MTADNGVGQRQTGGKYVEPGGEFNRDQNYITTRITADGRDGYPVEPGRYRLVVSRACPWANRLIIVRRLLGLEDVLSMGVTGPTHDARSWTFDLDPGGRDPVLGIERIQEAYFARYPDYPRGITVPAIVDVPTGQVVTNDYAQMSLDLSTEWTAYQRPGAPDLYPEHLRAEIDEVNAVVFRDVNNGVYKCGFAGSQEAYDKAYHRLFDRLDWLSDRLAGQRYLVGDTITEADVRLFTTLVRFDPVYHGHFKCNRQKLSEMPVLWAYARDLFTTPGFGDTVDFDHVKRHYYEVHRDINPTGVVPLGPDLSNWLTPHDREALGGRPFGNGTPPPPPSPTEQVNPAHTPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDW1</accession>
    <name>F4FDW1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="8">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="8">DXP synthase</shortName>
            <shortName evidence="8">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dxs</name>
        <name evidence="10" type="ordered locus">VAB18032_12640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732310.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12640"/>
    <dbReference type="EnsemblBacteria" id="AEB43642">
        <property type="protein sequence ID" value="AEB43642"/>
        <property type="gene ID" value="VAB18032_12640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12640"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_11"/>
    <dbReference type="OMA" id="FAPQGMF"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="9">
        <location>
            <begin position="325"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="8">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="8">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="650" mass="68950" checksum="412E84439D73DE75" modified="2011-06-28" version="1">MSAEEDTANHGRLLARVHGPQDVRRMSGTELDNLAAEIRDFLVAKVSRTGGHIGPNLGVVELTLALHRVFDSPRDRLLFDTGHQAYVHKIITGRQDGFDQLRQRGGLSGYPSRAESEHDIIENSHASTALSYADGLAKAYALRGEARSVVAVVGDGALTGGMCWEALNNIAAAGNPLVIVVNDNGRSYAPTIGGLADHLSTLRLNPGYEKVLDAVKDALGSTPLVGKPMYEVLHAVKRGIKDAVAPQAMFEDLGIKYVGPVDGHDVAAVETALRAAKNFGGPVIVHAVTRKGYGYRPAEEDEADCFHGPGAFDIATGKATAAPTVKWTNVFADELVKIADERPDVVGITAAMAEPTGIAKLARKYPERTYDVGIAEQHAATSAAGLALGGLHPVVAVYATFLNRAFDQVLLDVAMHKLPVTFVLDRAGITGPDGPSHYGIWDMSVFGVVPGLRMAAPRDAATLREELREAVAVDDGPTVVRYPTGAVAADLPAVRRVGTVDVLTESERADVLLVAVGSFGQLGMEVATRLAEQGYGVTVVDPRWVRPVPAELVELAAGHRLVVTVEDGVRIGGVGDALAQAMRDADVQVPLRDLGVPADWHPHGSRAQILADLGLTAQDVARDVTGWISRLDTQTVEPLPVPTNNTPTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE31</accession>
    <name>F4FE31_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733555.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18990"/>
    <dbReference type="EnsemblBacteria" id="AEB44900">
        <property type="protein sequence ID" value="AEB44900"/>
        <property type="gene ID" value="VAB18032_18990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18990"/>
    <dbReference type="eggNOG" id="ENOG502ZECI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097136_0_0_11"/>
    <dbReference type="OMA" id="WHIGWWW"/>
    <dbReference type="OrthoDB" id="1920669at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="20676" checksum="C0602F6B4E05A8F1" modified="2011-06-28" version="1">MSSSRRDLLRWQFDLTWSLFDYHLQRLTPAQFRWEPVAHCWTVRRDAAGRWVPDWADTEPDPVPVPTVAWLTWHIGWWWSVALDHLQGRPPRERTEIHWPGDGTPTIEWLDELRTQWHDVLNRLTDADLDQVAPFPWPYDPEHTVAHLLAWVNAELMKNAAEIGQLRLLHQADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEG6</accession>
    <name>F4FEG6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01620"/>
    <dbReference type="EnsemblBacteria" id="AEB47408">
        <property type="protein sequence ID" value="AEB47408"/>
        <property type="gene ID" value="VAB18032_01620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01620"/>
    <dbReference type="eggNOG" id="COG3423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059166_0_0_11"/>
    <dbReference type="OMA" id="CEVRLHD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="240" mass="27248" checksum="DF8F90DD13936C69" modified="2011-06-28" version="1">MLKKGLTPATLADKLGVDPKTVERWVTQSRNPYPRYRHSIAELLDESEAYLWPDALPTQRAMQVSQSEVVHIYPRRGAVPTDLWQQLLEKATRQVGVLVYGGLFLPEFNHRWVPTLREKALAGAQVELLFGDPEGKHVAERGDDEGIGVAMSTKILNALAFYKDLRDLDTVGIYYHDTILYNSIYRFDDEMLVNTHLYGTPAAYAPVLHLRRLGGGDLFDSYVASFNRVLGKKRAVWPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEK8</accession>
    <name>F4FEK8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01830"/>
    <dbReference type="EnsemblBacteria" id="AEB47450">
        <property type="protein sequence ID" value="AEB47450"/>
        <property type="gene ID" value="VAB18032_01830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01830"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="CSTMGVT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="28661" checksum="B628D052CCF1CA70" modified="2011-06-28" version="1">MSVGAGRDRDGSASAPAIEAVDVSRTYQLDGVSVPALRGVSLTVAAGDYVALIGPSGSGKSTLMHLLGGLDRPTGGRLVIGGREVGALSAPELARLRNETIGFVFQAFHLLPRTTAVDNVALPLVYRGVGARQRRERAAAMLGRVGLGHRLDHRPNQLSGGEQQRVAIARALVTDPTVLLADEPTGNLDSTTGAAVLELLERLNAESGVALVMVTHDAEVAARARRRITMRDGVVVADSAQDADSAQDPLTGGVGFDEPGAVGLGTARAGGLGAAGAGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF98</accession>
    <name>F4FF98_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19505"/>
    <dbReference type="EnsemblBacteria" id="AEB45003">
        <property type="protein sequence ID" value="AEB45003"/>
        <property type="gene ID" value="VAB18032_19505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19505"/>
    <dbReference type="HOGENOM" id="CLU_3067414_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="53" mass="5591" checksum="F7DBBED32458D61C" modified="2011-06-28" version="1">MVIDVAPGARRRAGGVRVVRGDRHRVAFDATKASSGIDEMPLRSSARPALTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFA5</accession>
    <name>F4FFA5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Ribulokinase</fullName>
            <ecNumber evidence="3 4">2.7.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araB</name>
        <name evidence="7" type="ordered locus">VAB18032_19540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17601"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17173"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the ribulokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.16" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733665.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19540"/>
    <dbReference type="EnsemblBacteria" id="AEB45010">
        <property type="protein sequence ID" value="AEB45010"/>
        <property type="gene ID" value="VAB18032_19540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19540"/>
    <dbReference type="eggNOG" id="COG1069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_9_1_11"/>
    <dbReference type="OMA" id="GHKAMWH"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008741">
        <property type="term" value="F:ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07781">
        <property type="entry name" value="FGGY_RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00520">
        <property type="entry name" value="Ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005929">
        <property type="entry name" value="Ribulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01234">
        <property type="entry name" value="L-ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="5">
        <location>
            <begin position="11"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="6">
        <location>
            <begin position="294"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="561" mass="59395" checksum="7E7DDB33A832057C" modified="2011-06-28" version="1">MSGVGEVGDRYVVGVDYGTLSGRALVVRVRDGAELGTAVHEYRNAVIESALPDGGPSLPPDWALQDPQDYRDVLRHAVPAAVAAAGVDPRDVVGIGIDFTACTILPTLADGTPLCEVPELRQRPHAWVKLWKHHAAQPHADRINALAHERGEPWIGRYGGKISAEWQFAKGLQLLEEDPEVYRRADRFIEAADWIVWQLCGIETRNVCTAGYKGIMQDGKYPSTDYLTALNPDFGDFVTKLDGPLMPLADKAGELTAAAAAWTGLPQGIAVAVGNVDAHVTAASAQALAPGRLVAIMGTSTCHVVNGAQPAEVAGMCGVVEGGISAGAWGYEAGQSGVGDIFGWFVKHAAPAEVASHERLTELAAAQPVGAHGLVALDWWNGNRSLLVNHDLSGMIVGLTLATRPEDVYRALLEATAYGTRMIIEAFVEAGVPVNDLVIAGGLTSNTLLMQIYADVTNRPLSIIGSAQGPALGSAIHAAVAAGEYSSIHEASQAMGRISEAVYRPDPDRVRAYDALYAEYRTLHDHFGRGTNDVMLRLRAIRNAAAGSAASTNETASEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG26</accession>
    <name>F4FG26_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43770">
        <property type="protein sequence ID" value="AEB43770"/>
        <property type="gene ID" value="VAB18032_13290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13290"/>
    <dbReference type="HOGENOM" id="CLU_2048728_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="12448" checksum="8F3AB845EA0107C4" modified="2011-06-28" version="1">MVVPGASDLHGATHQALAEALAKHGRALLNEASRLEAAANPGLAAPMITPGMIHDAETLQRIGYAQSGKAADRRNWMLGSLAATFVGGFFTNNLTEPWGAIGFVVCGALALAFFNKGSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG37</accession>
    <name>F4FG37_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732448.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13345"/>
    <dbReference type="EnsemblBacteria" id="AEB43781">
        <property type="protein sequence ID" value="AEB43781"/>
        <property type="gene ID" value="VAB18032_13345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13345"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080966_0_0_11"/>
    <dbReference type="OMA" id="MQDTEWS"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="41"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="28218" checksum="4C8DE394394A41DC" modified="2011-06-28" version="1">MKASFSGEVATYYARHRRGYPPEVLDALVEAFDLGPDDTAVDLGCGTGQLSLPLAARVGTVIGVDPEPDMLALARHAALNAARPNTMWLLGDDSDLPTLGRLLGDRTIGALTVAVAIHFMDRDALFRTVRPLLRPGGGIAVITNGAPLWMQDTEWSGALRECLQRLLGHPVTATCQTDEPGRLHHQNALVRAGYRYAESLVQYDAVLTIDDMIGGVFSAMSAERLPSAQGRARFTDELRDALGGRDRVTERVRVWVQFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGG1</accession>
    <name>F4FGG1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_19985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733754.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19985"/>
    <dbReference type="EnsemblBacteria" id="AEB45099">
        <property type="protein sequence ID" value="AEB45099"/>
        <property type="gene ID" value="VAB18032_19985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19985"/>
    <dbReference type="eggNOG" id="COG2212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125825_3_1_11"/>
    <dbReference type="OMA" id="MCGLAVW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="87" mass="8859" checksum="9F83D580D86D469C" modified="2011-06-28" version="1">MTIVAVTVTALLAVAGALTLTRIIRGPSILDRAVATDVLLAIIVAAIATEAAYSKDATALPVLVVLAVLGFVGSVSVARFAARRNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGH0</accession>
    <name>F4FGH0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein VAB18032_26035</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734956.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26035"/>
    <dbReference type="EnsemblBacteria" id="AEB46305">
        <property type="protein sequence ID" value="AEB46305"/>
        <property type="gene ID" value="VAB18032_26035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26035"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059558_0_0_11"/>
    <dbReference type="OMA" id="TVMSFGF"/>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="32933" checksum="B04803A77E8C925E" modified="2011-06-28" version="1">MGEAHTNGHHVGGTGAAETDTTLVVVTGLSGGGRSTVARALENVGFYVVDNLPQALLLDMAELAVKAGGAARRTAMVLDVRSRAFSTDLAEAIRELKERGYAPRVVFVDADDEVLIRRFESVRRSHPLQGDGRLADGIAVERGLLEEARDQADVIIDTSHLNVNQLRRRIEELFGGEDARKLRVTVISFGFKYGLPPDADFVLDARFLPNPYWVPELREHTGREEAVSAYVLGQEGADTFVSAYADLVGATTAGFEREGKRYLTVAVGCTGGKHRSVAIAEELAARLRRAGLAANAQHRDLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGP9</accession>
    <name>F4FGP9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736192.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02375"/>
    <dbReference type="EnsemblBacteria" id="AEB47559">
        <property type="protein sequence ID" value="AEB47559"/>
        <property type="gene ID" value="VAB18032_02375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02375"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064468_0_0_11"/>
    <dbReference type="OMA" id="SFVGAEW"/>
    <dbReference type="OrthoDB" id="1508782at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="36807" checksum="93D18F0B16DD5EF8" modified="2011-06-28" version="1">MSLFRTELRRLAKRRFTRWMTAGGLLILALVVVGLFVTNEKIGTEQWAEARRAADSSHAEQVRWAEQERANCERAKAAGENVDYYPADCASIAPPAREDIQDEWYLPSTFVFKASVPDMLVTLAGILAMVGFVVGASFIGAEWNTGGMMNLLLWRPKRLSVLLTKLGALLTGMLAVALSASVAWFGILWLIASWRGTTDGMTSGVWQSFLLTGLRGVVLVLVAATVGFALASLGRHTAMALGGAVAVMVVGQAGLAILLDLAQVRFGEAWLLPTYVYAWMTKTLTLEDWRSCNASYTGECNPATLDITWQHSSILFTVAVVIFLGGALWTLRRRDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGS8</accession>
    <name>F4FGS8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02520"/>
    <dbReference type="EnsemblBacteria" id="AEB47588">
        <property type="protein sequence ID" value="AEB47588"/>
        <property type="gene ID" value="VAB18032_02520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02520"/>
    <dbReference type="eggNOG" id="ENOG502ZQMM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1905535_0_0_11"/>
    <dbReference type="OMA" id="AETTHNQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="14664" checksum="5FC18B8A7F84C3EB" modified="2011-06-28" version="1">MHMPQIEVDDATDRYLTFAAGITGMTKGQLVARLVEQAQAAAAPEPATPDGDEPASVRVYADYAGHRTYGMFVPGPGRIEITSGPLAGRSFRTPSQAAREIVQHYNPAVSPHRNGWSFFFVAATGAPLQSLRHRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGW6</accession>
    <name>F4FGW6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_02710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736258.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02710"/>
    <dbReference type="EnsemblBacteria" id="AEB47626">
        <property type="protein sequence ID" value="AEB47626"/>
        <property type="gene ID" value="VAB18032_02710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02710"/>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_3_0_11"/>
    <dbReference type="OMA" id="HCVQWLI"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="12">
        <location>
            <begin position="27"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="13">
        <location>
            <begin position="465"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB47626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="564" mass="58578" checksum="2450DFC377589649" modified="2011-06-28" version="1">MELPTVGLPALPRLLSAPAPGWVETTDVIVVGSGVAGLTAALHLREAGLHVTVVTKVNIDEGSTRWAQGGIAAVLDPADTPAMHASDTEIAGVGLCDPAAVGVLVEEGPTRLRELIRIGAAFDRNPDGSLMLTREGGHRADRIVHAGGDATGAEVQRALHEAVRRDPWIRLVEHALVLDLLRAPGDGPDGLGRACGITLHVLGEGSEDGVGAILSRAVVLATGGMGQVFAATTNPAVSTGDGVALAMRAGAAVTDVEFVQFHPTALIVPEQARTPGDGHAQQPLVSEALRGEGAHLVDADGKRFMLGQHELAELAPRDVVAKGIHRVLLATGADHVYLDARHLGGDFLARRFPTIVASCLAIGVDPGVDLIPVAPAAHYASGGVRTDLHGRTSIPGLYACGEVACTGVHGANRLASNSLLEGLVFSRRIADHIAAGLPEQARPAETGAWRGGDGWVLPAAATPVLQRAMTRGAGVLRSSATLAGTAAELVELGAGRGTPRTADWEATNLLTVATMLVAAAYARQETRGCHWREDHPSADARWHGHLVGAIGTQNRLAMRWEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH06</accession>
    <name>F4FH06_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07490"/>
    <dbReference type="EnsemblBacteria" id="AEB42620">
        <property type="protein sequence ID" value="AEB42620"/>
        <property type="gene ID" value="VAB18032_07490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07490"/>
    <dbReference type="eggNOG" id="COG3685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618306_0_0_11"/>
    <dbReference type="OMA" id="AKTCEAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="164" mass="18473" checksum="60BCFE97A3B3814F" modified="2011-06-28" version="1">MKTANEIFFYELAAMQDLEHQARSILGLLIGTRIQDSTLKRIIEDMAHASERHSDRIDACLRHLGTAPLQTRSAPIRGVQDDFQVFLRTPHNDAVRDLYALNAAQRITKLAIAGYEHLTDWATTIAAVTCTQCLLKNLIEKTETSQQLRKLNQTLSEQLLATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH31</accession>
    <name>F4FH31_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07625"/>
    <dbReference type="EnsemblBacteria" id="AEB42645">
        <property type="protein sequence ID" value="AEB42645"/>
        <property type="gene ID" value="VAB18032_07625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07625"/>
    <dbReference type="eggNOG" id="ENOG5033K3U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1914662_0_0_11"/>
    <dbReference type="OMA" id="HIPCHAT"/>
    <dbReference type="OrthoDB" id="2076252at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="122" mass="13449" checksum="130D0CF636663B2E" modified="2011-06-28" version="1">MNSTPHPGNEPDPDSPVRLNVGDPDLRKTRLLARECATCIFKPGNPMHLAPGRLKQMVTTARGDAGYIICHSTLPYAGSPVPPAVCRGFADRYRTWQLQVMQRLWGFVEVEPPTPNTAEAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH66</accession>
    <name>F4FH66_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-hydroxamate transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_13660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13660"/>
    <dbReference type="EnsemblBacteria" id="AEB43844">
        <property type="protein sequence ID" value="AEB43844"/>
        <property type="gene ID" value="VAB18032_13660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13660"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_7_2_11"/>
    <dbReference type="OMA" id="MFPYQIP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="702" mass="70748" checksum="C0553626CDFCE4EB" modified="2011-06-28" version="1">MTELSAPPRSEPALGPAPAGRLSGTRVVGAFIAATALALVVAVVHLTQGTSAVGALDLLRLLTGGDDETVRVLVASRMPRLLAGLAIGVALGFAGAALQSIARNPLASPDTLAVNAGAHLAIVSVAAFGIALPALPAGGLAFCGGLAAAGLVMAMSSGGQAGTTRLILAGSATALALSSVTMLLLLLFEQATIGLFAWGNGSLVQSDLNALTQLAPVIGLAIVALMLLGHRLDILALGDDTATVLGLDVRRTRLIVTVLAVLLSAAAVTLTGPVGFVGLCAPVIVRLLGPLVPGVHRHRVLLPLSGIAGMIIVLGSDVLLRAAMGAQAGVDIPTGVVTTLLGAAILIWLARRHRDAGPTRRPPGGHAAVRSAGFHRTVVIVVATVAGVAVVVGMLAGDTWVLLGDLVNWVNGNTGPAYTFVLDQRWPRVAAALLAGAALAVAGTTVQAVCRNPLAEPGILGITAGAGLGAVSLITFVPLASVWAVSGVAGLGAMLAFALVYGVAWRGGLSSDRLVLIGFGAWQGGMALITFLIVAHDPWNTGKALTWMSGSTYGRTATQVLPVAIALLVLTPAVLAARRELDLMALDDDTPRVLGVRLERTRLVALGAAALLTSTAVSAVGVIGFVGLVAPHAARALVGGRHARVLPVAALLGAALVSVADTLGRTVIAPAQIPAGLVTALIGTPYFVWLLWRSRASAPQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHB9</accession>
    <name>F4FHB9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732564.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13925"/>
    <dbReference type="EnsemblBacteria" id="AEB43897">
        <property type="protein sequence ID" value="AEB43897"/>
        <property type="gene ID" value="VAB18032_13925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13925"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_1_11"/>
    <dbReference type="OMA" id="VMYEGWR"/>
    <dbReference type="OrthoDB" id="1964641at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="21856" checksum="75A9EEAFF6EBE349" modified="2011-06-28" version="1">MASEPSPTPRRRGRPTVLDPEAVGTAALKLWAERGYGATGWDDISAATGISARTLMRHFPSKAALAWVGVPAATRRLTETFRTLPLDIPLSDALRAAVVASVSDDALVLSAGGYWMRVVAEEPELAEASARAYAPWTEALAREIARRRPGAPSAIYHAVATAYREAAQAALYDWARSPDGSPALAVDALLRRLDIRITTPEEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHE7</accession>
    <name>F4FHE7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733774.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20085"/>
    <dbReference type="EnsemblBacteria" id="AEB45119">
        <property type="protein sequence ID" value="AEB45119"/>
        <property type="gene ID" value="VAB18032_20085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20085"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_49_1_11"/>
    <dbReference type="OMA" id="NCYEEFG"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="31322" checksum="4D87EB0DA2AFFE35" modified="2011-06-28" version="1">MQRSTTVARLGSGAVEYRLERRGDTVVVVLHGGHLRAGLVWDETVFADADITVLAPSRPGYGRTPLSTGTTRAGFADVTAELCRHLGIDKVAAVLGISAGGPTAMTVAARHPDLVERLILQCPQGPRWPGRRDRLLANLIFSPVAERLTWSGLRWLLRRAPDAGLRMLLGGLSTVPPRQLLADVRPEHRATLIALFSAMRSGTGFRQDLRPYVDVTAEIGQPTLVIASRHDGAVSFDDAEHLASAIRRAVLVESRSDSHFLELGVDWPAISEAIRVFLATEPRDLAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHS8</accession>
    <name>F4FHS8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">leuS</name>
        <name evidence="15" type="ordered locus">VAB18032_26871</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735098.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26871"/>
    <dbReference type="EnsemblBacteria" id="AEB46447">
        <property type="protein sequence ID" value="AEB46447"/>
        <property type="gene ID" value="VAB18032_26871"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26871"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_11"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="72"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="300"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="807"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="727"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB46447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="952" mass="106087" checksum="854346D4816E4C2A" modified="2011-06-28" version="1">MSERQRASEAATPTSDTPPFRYTATLADEIERRWQDVWERDGTFHAPNPSGPLADPGHPRSGAEKLYVLDMFPYPSGAGLHVGHPLGYIGTDCFARYQRMAGRNVLHAMGFDAFGLPAEQYAVQTGTHPRTTTEANIERYREQLRRLGLAHDQRRSVATIDTDFYRWTQWIFLQIFNSWYDRDAGRARPISELTAEFAGGTRRTPDGRPWGELSAAEQRAIIDDHRLAYVSQAPVNWCPGLGTVLANEEVTADGRSERGNFPVFKRNLKQWMMRITAYGDRLLDDLDKLDWPEPIKLMQRNWIGRSTGAHIDFPTATAPIRVFTTRPDTVFGATYMVLAPEHELVDALVPGAWPEGTRDAWTGGHASPRAAVEAYRKAAAAKTDVERQADTKEKTGVFTGAYATNPVTGGQIPIFIADYVLAGYGTGAIMAVPAQDERDWDFAEVFELPIVRTVAPPEGFDGKAYTGDGPAINSAAPDRGLDLNGLGVADAKARIIAWLEETGNGQGATTYRLRDWLFSRQRYWGEPFPIVYDADGTAIALPEEMLPVELPEVDDFSPRTFDPSDADSDPETPLSRRRDWVEVELDLGDGPKRYTRETNVMPQWAGSCWYELRYLDPTNEGRFVDADNERYWMGPRSEGDCGGVDLYVGGAEHAVLHLLYARFWHKVLYDLGHVSSFEPFRKLFNQGYIQAYAYTDARGAYVPAEEVVERDGGFYLGDVQVNREYGKMGKSLKNVVTPDEMCAAYGADTFRVYEMSMGPLEVSRPWETRAVVGSYRFLQRVWRAIVDEQTGASRVVDTPADEATRRLLHKVIDGVRGDMEAIRFNTAIAKLIELTNGVTRLPATPREVAEPLVLMLAPVAPHIAEELWRRLGHDTSLTYADFPVADPALLVAESVTYPVQVNGKVRGRIEVPADATEESVREQALEAVAAVLAGKDPRKVIVIPGRMVSVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHY5</accession>
    <name>F4FHY5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_02970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736310.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02970"/>
    <dbReference type="EnsemblBacteria" id="AEB47678">
        <property type="protein sequence ID" value="AEB47678"/>
        <property type="gene ID" value="VAB18032_02970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02970"/>
    <dbReference type="eggNOG" id="COG4770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_3_11"/>
    <dbReference type="OMA" id="HLMGSKR"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
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        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="115"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="588"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="675" mass="70748" checksum="9B4B9AE4ABFF3B12" modified="2011-06-28" version="1">MIHKLLVANRGEIARRIFATCRTLGIETVAVHSDADADAPFVAEADQAVRLPGNSSAETYLRIDLILGAARRCGADAVHPGYGFLAENADFATAVAEAGLTWVGPPAKAIAAMGDKLAAKTLLAEAGVPMLPSWTEADQVTDFPVLVKASAGGGGRGMRIVRDPAGLAEAVAGARREAASAFGDGTVFIERYVERGRHVEVQIVGDRHGTVLALGERDCSIQRRHQKIVEEAPALLDAEVRARLHRAAVAAGQAVDYVGAGTVEFLFTEEGEFFFLEMNTRLQVEHPVTEAVTGLDLVRLQLLVAEGAPLPLSATPPAQGHAIEVRLCAENPAQGYRPAAGTLHRFAVPGVAAEFTPHQGLRLDSGVVDGSVVSVHYDSMLAKVIAWAPTRAEAARALAGALARAELHGVTTNRDLLVRVLRSPEFGATQVDTGFLDRHPEVLAPLLPPAELPLVALAAALASAAARRAAAPVLAGLPSGWRNVPAVPQVTRFTSGDGGEIEARYRLDRAGRLAHWSTSPVAADSTPATSTESDEASAETREAVTLVEAGPERVVLEVAGVRRAYRVHRVGSEVFVDGPDFAARLVESPRFPLPGAALAAGSLLAPLPGAVTRVHVEVGQQVAAGDLLLTLEAMKLEHPVFAPTDGVVTELPVPPGGRVDTGAVLAVVNPLEETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI06</accession>
    <name>F4FI06_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03075"/>
    <dbReference type="EnsemblBacteria" id="AEB47699">
        <property type="protein sequence ID" value="AEB47699"/>
        <property type="gene ID" value="VAB18032_03075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03075"/>
    <dbReference type="HOGENOM" id="CLU_3190366_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="46" mass="5877" checksum="8FCDA602AD4372EA" modified="2011-06-28" version="1">MKILWSLIYFLVFVPVGIFFRLFRDPLRRKWQPELSTYWIFDERPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI09</accession>
    <name>F4FI09_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736334.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03090"/>
    <dbReference type="EnsemblBacteria" id="AEB47702">
        <property type="protein sequence ID" value="AEB47702"/>
        <property type="gene ID" value="VAB18032_03090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03090"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056943_0_1_11"/>
    <dbReference type="OMA" id="RSCQRHV"/>
    <dbReference type="OrthoDB" id="1036370at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="269"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="354" mass="38819" checksum="A95489FC3397FA45" modified="2011-06-28" version="1">MTASLSFLSHPRGPLSSIESRAYEFAVLGNRIDADRPPPEVGISRSDWAHACESLLRRRLLSRADDGGLTAVHPEIALSILNAPLSDEIRQREEAMATNGRVIQSISMRLAQLAENGRQRDGVRVVRGEQALRDEIDAAILRCTTEIHSLRPGGLRSQDHFSASATSASSIFERGLRCQFLYHHTARSNLGLVARAKAVAEHGGGIRTTAASFERLVIFDRKLAFIPVDAPTAAGRGAAVISDELVVEYLYRTFVHLWANAVPLELPEDQMDEVSLDTRMAILRLMSAGLKDEAIANRLGMALRTCRRHISSILKGLNVSSRFQAGIKIAQLGILTDEVIDSEQSGRTDISPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI37</accession>
    <name>F4FI37_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30189"/>
    <dbReference type="EnsemblBacteria" id="AEB48001">
        <property type="protein sequence ID" value="AEB48001"/>
        <property type="gene ID" value="VAB18032_30189"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30189"/>
    <dbReference type="eggNOG" id="ENOG5032HUS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1593860_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="17713" checksum="28EADBC41975EFF6" modified="2011-06-28" version="1">MLDTAAVLDRYRAGLRDVPDVELERRAATVAALPGRLAAELRHLIDAEREYRQAVRRPISPPSGPVLNRARVAAAAAGVVSTGAVGAVFAGRALAEHADQVPQALVYSPAVAVGLVAVVAGGSRLARWFDDRRHPLAEDIAEADLNPLGRHLLAQVRAARQVRGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI56</accession>
    <name>F4FI56_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Relaxase/mobilization nuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30284"/>
    <dbReference type="EnsemblBacteria" id="AEB48020">
        <property type="protein sequence ID" value="AEB48020"/>
        <property type="gene ID" value="VAB18032_30284"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30284"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029419_1_0_11"/>
    <dbReference type="OMA" id="PTQAEMH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="502" mass="53604" checksum="198986A5C07E5FB0" modified="2011-06-28" version="1">MIPKVTYGSRVRGLLEYLWGPGKAEEHVNPHLVAGYDDVALLAPERYERDGGRWGLDDLAARLDAPQIAAGERGVKQYVWQCSLSLPAQEGQLDDDTWGRIAGRFVQEMGFTGDADRPGCRWIAMRHGLSAKGNDHVHLVITLATEDGAPVWLRQDKRRSQQVADLLEDEFGLGKWTPGRAGVTRRPELTRPEVDRARRSGLAPDRELLRRQVRAALAGAGSEAEWVARMKGAGLLVAARTAAKDVDQVAGYAVALRPAGGNKPRWFAGRSLDGDLSLPRIRARWSDEGRATAGQWADAHSVESPRLRGEDRIAVWRSSAAALEAISGRLRGLPPGSPQWPAVARASVELLAGVAAATEPSGQGPITRAADSLARAAAPRRSTRTSAASTVAVELGRVAHALLIAGRARDGGEAAVLLAVVVQAARLVVALAELRAAERQAHAAGAAAAAAAHLMPLLQQDGRHVNQVPTQTQTGAADRPTLPSPAPARTSVRRESDGELQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F162</accession>
    <name>F4F162_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731389.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07990"/>
    <dbReference type="EnsemblBacteria" id="AEB42716">
        <property type="protein sequence ID" value="AEB42716"/>
        <property type="gene ID" value="VAB18032_07990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07990"/>
    <dbReference type="eggNOG" id="COG3858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789725_0_0_11"/>
    <dbReference type="OrthoDB" id="349522at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004991">
        <property type="entry name" value="Aerolysin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03318">
        <property type="entry name" value="ETX_MTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307575" evidence="1">
        <location>
            <begin position="30"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="36765" checksum="0C0FAFC640BB30C5" modified="2011-06-28" version="1">MRVRKSAAVLSTVVTGWVMVLVAAQPASAAPNCNVPIPPPACGYEPPEDPPPPSGFVPVLAFDGARQTVSRDGVHVWGWTADNDAPTTALNVNISIDGTQVRSMVANQHRPDVAAAYPNYGAAHGFEVVLPASAAGHNVCVTAISVGGGANKSVCRQMDDIVEFMAYGINYDIARAQLVGTSLQQLDKVTNRNDTTLQQSTEISGSKTVTETEGWSDTAGVKVSVSTSIKAGFPIFADGKVTVSAEGSFSYTQNGSTSRSRTVSWRQPVLVPARSIVEATVTVTHANIRVPYSLSGEFIYRSGARAAGTVGGMFAGGNSENVQVNLKQYNLDGSPAVAPAKQPQATMLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F178</accession>
    <name>F4F178_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyguanosinetriphosphate triphosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14010"/>
    <dbReference type="EnsemblBacteria" id="AEB43914">
        <property type="protein sequence ID" value="AEB43914"/>
        <property type="gene ID" value="VAB18032_14010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14010"/>
    <dbReference type="eggNOG" id="COG0232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028163_0_1_11"/>
    <dbReference type="OMA" id="AMLKYPW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="59"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="499" mass="54780" checksum="520D22CC325C5C88" modified="2011-06-28" version="1">MEPRARRLFGGSARALGDLATSPFRTDRDRIVGSPFFARLGGVTQVVSPGGSGLLVHNRLTHSLKVAQVARAIAERLTADGWQRDLAEKLGGCDPDVVEAAALAHDLGHPPFGHLGERVLDRLARHRLGLPDGFEGNAQSYRIVTSTEIRGAATTGLDLTAAVRAAMLKYPWTRLDHPDPHPRLLDPPPRGASPPPDDPDSGSAKFGAYRTEVDDLRQARAPFVGRIADWQQTVEASVMDIADDIAYAIHDVEDFYRVGVLQQGAVAAELMAWQREGGHLRAITDAALATSARRPGAAIERLRRQLHRKDGWVADDDAFASAVEHVREELVDGLLAMPFDGSIEAEQYVARFSARWTTRLVDAITITEKPSLRSGHVLLAPPQWHEVQVLKFVHHRFVLARPDLALHQRGQARLLGTLVEALLEWLLDPEEESRLPRRLHDLVELAEAELHPRTPDRIGKARGRAIVDFVAQLTDGQAVAMLDSLSGRSGALWTDAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1C3</accession>
    <name>F4F1C3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732626.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14235"/>
    <dbReference type="EnsemblBacteria" id="AEB43959">
        <property type="protein sequence ID" value="AEB43959"/>
        <property type="gene ID" value="VAB18032_14235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14235"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_5_1_11"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="OrthoDB" id="833478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="45"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="204"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="35371" checksum="A20718C38E505D33" modified="2011-06-28" version="1">MPAITVDNVLVLPRLPRLDESTTTIRPVRRLTTAPSGFEGEGFPVRRAFAGVPTSELDPFLHLDQMGEVEYAPGEPKGTSWHPHRGFETVTYIIDGIFEHQDTHGGGGTITNGDTQWMTAGSGLLHIEAPPEHLVVSGGLFHGTQLWVNLPKVAKMSPPKYQDIRGNQAALLTTPDGGALIRVIAGEIAGHQGPGSTYTPITVTHVTVEPGAQVDLPWRPDFNALVYVLGGRGTIGANGRGVRTGQLAVHGPGDALRLRANARQDSRTPTLDLYIMGGQPIREPVAQYGPFVMNSRDELIQAFEDYQAGRLGVIPAERLAHTDGQGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1G2</accession>
    <name>F4F1G2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine exporter protein (Lyse/ygga)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45191">
        <property type="protein sequence ID" value="AEB45191"/>
        <property type="gene ID" value="VAB18032_20455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20455"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079569_3_2_11"/>
    <dbReference type="OMA" id="YMFCAAF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="19958" checksum="C84C988AE64B4306" modified="2011-06-28" version="1">MVYLVSRSVTQGRRAGLISLLGVAAGFAVYLAAAVAGIATVFVLVPALYTAVKVAGAGYLLWLAWQAVRPGGHSPFTPTPLPADPNRRLFTMGLVTNLLNPKIAILYVSLLPQFIDPSRGAVAVQSLLLGSTQIAVALTVNGLIVLTAGSIAGFLGRRPLWLRAQRLVMGTVLAALAVRIAADRSHAAVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1N1</accession>
    <name>F4F1N1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733914.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20800"/>
    <dbReference type="EnsemblBacteria" id="AEB45260">
        <property type="protein sequence ID" value="AEB45260"/>
        <property type="gene ID" value="VAB18032_20800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20800"/>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_2_1_11"/>
    <dbReference type="OMA" id="LFKNFAD"/>
    <dbReference type="OrthoDB" id="1594801at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="154" mass="17010" checksum="D6D9FC64AF4303A9" modified="2011-06-28" version="1">MRELSVVGVRVELPSNQPIVLLREVEGDRYLPIWIGAVEATAIAYEQQGVKPARPLTHDLLRDVLAALKAPLRAVEITELKENVFFADLLIGDGVRVSARPSDSIALALRVGAPIRCAEQVLSEAGIVIPDEQEDEVEKFREFLEQVRPEDFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Q7</accession>
    <name>F4F1Q7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="10">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="10">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp</name>
        <name evidence="12" type="ordered locus">VAB18032_27046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735133.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27046"/>
    <dbReference type="EnsemblBacteria" id="AEB46482">
        <property type="protein sequence ID" value="AEB46482"/>
        <property type="gene ID" value="VAB18032_27046"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27046"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_0_11"/>
    <dbReference type="OMA" id="TNRDNPF"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="2"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="10">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB46482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="36548" checksum="28E4BC8BD4432DAF" modified="2011-06-28" version="1">MRIGVLTGGGDCPGLNAVIRAVVRKGVASYGHEFVGFRDGWKGPLEGLSRPLGIAEVRGILPRGGTILGSSRTNPFKIENGVERIKENLAAQGVDALIAIGGEDTLGVATKLHELGVHVIGVPKTIDNDLGATDYTFGFDTAVNIAMEAIDRLHTTAESHHRTLVVEVMGRHAGWIALHAGLAGGANVILLPERAFDVEQVAGYVEKRFQHQYAPIVVVAEGAQPLEGQMVLQNQELDAFGHVRLGGIGQWLAEQLEAKTGKEARTVVLGHIQRGGTPTAFDRVLATRLGLQAIDAAHEGDWGKMVAMQSTDIVRVPLADATRELKTVPLERYAEAEVFFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Y1</accession>
    <name>F4F1Y1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_03220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736360.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03220"/>
    <dbReference type="EnsemblBacteria" id="AEB47728">
        <property type="protein sequence ID" value="AEB47728"/>
        <property type="gene ID" value="VAB18032_03220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03220"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_11"/>
    <dbReference type="OMA" id="GLQLGYM"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="334" mass="36905" checksum="D2EB9B05F6B54CCC" modified="2011-06-28" version="1">MFRFIIRRLLQLIPTLFGLSILLFIWLRRLPGGPETAILGERGTPEMRAAIRRNLGLDEPILIQYGRFVKRMIRLDLGTSISTKREVTTEFLQRFPGTIELTITAMVIAIGIGIPLGYLAARKRGRFLDYASVGGSLIGICIPVFFLAYVLKAIFSENLGWFPSSGRQDPILGATRITNFFVLDGLMTREWDAAADALWHLVLPGMALASIPLAIIVRITRASVLEVLGEDFVRTAEAKGLTENVVRRRHVLRNAMLPVATSIGLLTGGLLSGAVLTETVFAFSGIGAFLAESISNRDYPVLMGFIMIIAVVYVMVNLIVDLSYSLIDPRVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F225</accession>
    <name>F4F225_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736404.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03440"/>
    <dbReference type="EnsemblBacteria" id="AEB47772">
        <property type="protein sequence ID" value="AEB47772"/>
        <property type="gene ID" value="VAB18032_03440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03440"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082597_0_0_11"/>
    <dbReference type="OMA" id="GWYGPWT"/>
    <dbReference type="OrthoDB" id="1340956at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="54"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="27352" checksum="59EB0AB45850726F" modified="2011-06-28" version="1">MASTKLAPAATSGLAAMLPERLLGAAIRRAYPRVEPELARLAEFVPSGGTAVDVGAWYGPWTARLLRRAERVVAVEPTAALAGQLRSAFPTVEVVEAAVSDHEGSATLYLPAGGAIVGTSSLEDPTQGEPVPVRRITLDSLGLTDVRFVKLDIEGHELPALRGAAETVKRDRPVLLIEVEERIQPVEPLLDLLTGWGYRGYVLPEREWVPLADFDLGGHQREAIVRVGQSFARRVVWPRPRYVNSVLFRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F270</accession>
    <name>F4F270_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731430.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08205"/>
    <dbReference type="EnsemblBacteria" id="AEB42759">
        <property type="protein sequence ID" value="AEB42759"/>
        <property type="gene ID" value="VAB18032_08205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08205"/>
    <dbReference type="eggNOG" id="COG3428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082134_0_0_11"/>
    <dbReference type="OMA" id="TDMKYEQ"/>
    <dbReference type="OrthoDB" id="1750498at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="193"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="32787" checksum="DE2A48B7E6E1D478" modified="2011-06-28" version="1">MGSPSGPPFDPDDPDRARREQDTEPIPRIDPDDGPGRGPGSRPDPYSSDGPFFSDDAGYGPGPDYVDDDRSGRAWVRDPEAGYQPPQISEDELAGLRADASGMTPRRVLPLEDEPSSLVARYLFPTERYRGEWKRHWVHLATPIVVGVAATFVLGYLSGFLAGQDVGALTTVAVLLWFAVMGWVAWKVADWWYDRFILTNKRVMVVNGIITRKVAMMPLTRVTDMKYEQSPAGRALNYGTFVLESAGQEQALREVKNLPNPNELYLRVVEEMYEPQAVEARLGKEQDEAKADDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2J1</accession>
    <name>F4F2J1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732730.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14755"/>
    <dbReference type="EnsemblBacteria" id="AEB44063">
        <property type="protein sequence ID" value="AEB44063"/>
        <property type="gene ID" value="VAB18032_14755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14755"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_0_11"/>
    <dbReference type="OMA" id="GAWGTNC"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="239" mass="24527" checksum="C7DF749C08188163" modified="2011-06-28" version="1">MLVAGFPADAFGTNCYVVATGPGEQCVVVDPGIGVIDRLDALLAEHRLHPAAVLLTHGHLDHTFSVAPVCGARGITAYVHPGDRELLADPAKALSMDLTQLFGGRLPYAEPEDVAELSDGATLTLAGLEITVDHAPGHTGGSVLFRLPGAGSPWEADQVCLSGDVLFAGSIGRTDLPGGSMPTMLTSLRDKILPLADDTVVLPGHGPATTIGRERATNPYLAEVAGMGGGRPAASTRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2L4</accession>
    <name>F4F2L4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polysulphide reductase nrfd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_20895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20895"/>
    <dbReference type="EnsemblBacteria" id="AEB45279">
        <property type="protein sequence ID" value="AEB45279"/>
        <property type="gene ID" value="VAB18032_20895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20895"/>
    <dbReference type="eggNOG" id="COG3301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045348_0_0_11"/>
    <dbReference type="OMA" id="RFYNMLR"/>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="34684" checksum="993E9D515EC914E2" modified="2011-06-28" version="1">MNSQQPPVGERFRRSRQRRDAGLTVPPAEFSSYYGRPILKPPVWTWEIAAYLFTGGVAAGSSLLAAGGQLTGRPAMRRAGRVAALAAVTASAGLLVKDLGRPERFHHMLRVAKPTSPMSVGTWILAAYGPAAGLAAVAEAAPLLPRRGPLGLARRVLPPVGRVAGLAAAATAPALGTYTGVLLADTAVPSWHEAYPYLPVVFAGSALASGAGVGLIAVPPAQAGPARRMAVAGAALELYGAHQVESRLGLLSEPYRTGRAGQLLRAGRALTAVGVAGAVLGGRSRVVAALSGAALLAASVATRFGVFRAGVASARDPRYTVLPQRERLARRRAADIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2T4</accession>
    <name>F4F2T4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">VAB18032_27361</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735195.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27361"/>
    <dbReference type="EnsemblBacteria" id="AEB46545">
        <property type="protein sequence ID" value="AEB46545"/>
        <property type="gene ID" value="VAB18032_27361"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27361"/>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002982_0_2_11"/>
    <dbReference type="OMA" id="AWMVRCA"/>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="579"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB46545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="647" mass="65247" checksum="C2A73D0078F33A56" modified="2011-06-28" version="1">MSLDGWNRVLVLGGIRSGKSEFAESLVADAATVRYVATAAGDDDAEWAARLAAHRARRPAGWSTEETASDPRRLADVISAARPDETLLVDDLGGWVTVLLDPAHQPADDTVTIDELITAVRGCAARLVLVSPEVGLSLVPTTPLGRAFTDALGVVNRAVADVCDVVLLVVAGQPCQLKPATAPALSTATEVTATEVTATGAAVPATGATVPTQAGPVMAAVPTPVSPPVTTPLPPAGSAYAAPTPTIVEPVAAGGPAIEPGLELPMPDEYAGPQAVERLATLDVPGRGFGVLAQVVSFAAGTQGTSTPQPWRSVRVLLLHGDHQGGAAAGTLPGESGRRADQARAGQGVLARLAAEGAAGLQVIEAPTAAPIEHEPALTAEQVESALSYGWQLAEEAADAGVQLLVLAACGAGTEAAAAAVLAATAGAEAPAVLARVINESGEFDDASWMIRCAAIRDALHRTRGVARDAKEVLAQLGGGDIAVATGVLLGATARRTPVLLDGPVGVAAALVSRDLAGQARHWCLLADDGDQPAVRLAADVLGLTPLAQLKLDLGEGANALTVLPVLRSALTLAAALPSRPDRTAGAGPDDTSRNDTGPDDSGSPQADEAPEPDAESEPDFREPEPDGPGPTSTQPAPADHSGSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Y9</accession>
    <name>F4F2Y9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional DNA primase/polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735250.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27636"/>
    <dbReference type="EnsemblBacteria" id="AEB46600">
        <property type="protein sequence ID" value="AEB46600"/>
        <property type="gene ID" value="VAB18032_27636"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27636"/>
    <dbReference type="eggNOG" id="ENOG5033DHD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092810_3_0_11"/>
    <dbReference type="OMA" id="RGAVQWA"/>
    <dbReference type="OrthoDB" id="1601056at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="223" mass="24618" checksum="E38B60A9D64E9C64" modified="2011-06-28" version="1">MWENVGPRVAHLSPLERVRLRRVAVRYAMHGWEVTPGACLARSRFVCGRAGCPTVGCHPALEDWEHAASADPARVANWWRSRPHGVLLPTGRSFDVLEVAADLGRRVLDAVRAHPAGLGVRGPVLVTPTGRWMFLVRPGDPLRPELEHCLQVVRHGPGSWIAAPPTRLPEGPVRWMVAPEQARWQLPDSYLVQNTLIDALRATGITLVPALVPGHLPLPRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F313</accession>
    <name>F4F313_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736424.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03540"/>
    <dbReference type="EnsemblBacteria" id="AEB47792">
        <property type="protein sequence ID" value="AEB47792"/>
        <property type="gene ID" value="VAB18032_03540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03540"/>
    <dbReference type="HOGENOM" id="CLU_1721579_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="15528" checksum="BAFBB994182C2027" modified="2011-06-28" version="1">MSTTPSGAFPPPGRRPIVVTLAVVLMVPSIVTWLIAGIAFFRAMLAAEGTGPGRVLVVGIGAGVLAIALLMVLLAALGILMAWTGDSAQGLAVPAGFTFGLFVVVIVVLLVQGKLTFEPTMVTPLVVGGLAGVALALVKSPPARAWFASRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3A8</accession>
    <name>F4F3A8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731503.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08570"/>
    <dbReference type="EnsemblBacteria" id="AEB42832">
        <property type="protein sequence ID" value="AEB42832"/>
        <property type="gene ID" value="VAB18032_08570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08570"/>
    <dbReference type="eggNOG" id="ENOG502ZHN2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1912603_0_0_11"/>
    <dbReference type="OMA" id="EWEPVVC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="143" mass="15131" checksum="43D8938FFC587AF5" modified="2011-06-28" version="1">MGALVTLDLPSDSPLSELPWIITFGPLGDDEWEPVVCGPYERPHALALAEALVADDELMAVVEPLIPAVSVDQIRGEIAAAQLAAADETVQVERADLYGDYEDTIDEEELAAEDDHATGPLPVPDVAELRAGFARIAAQLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3H3</accession>
    <name>F4F3H3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">alaS</name>
        <name evidence="13" type="ordered locus">VAB18032_14845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732748.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14845"/>
    <dbReference type="EnsemblBacteria" id="AEB44081">
        <property type="protein sequence ID" value="AEB44081"/>
        <property type="gene ID" value="VAB18032_14845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14845"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_11"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="1"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="741"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="682"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB44081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="892" mass="96708" checksum="C581F0138B5BBA73" modified="2011-06-28" version="1">MKTAEIKRRYLAHFEANGHAVVPSAPLPAISDPNLLFVNAGMVQFVPYFLGQQSPPFPRAVSVQKCIRTPDIDEVGKTSRHGTFFQMNGNFSFGDYFKDGAIPFAWDLATKSVEAGGFGLDPERIWATVYLDDDEAYDIWLHTGVPAERIVRRGKKDNFWSMGIPGPAGPCSELYYDRGPEYGLEGGPEVDEDRYLEFWNLVFMQYEIADVRSKEEFRIVGELPKKNIDTGMGLERMASILQGVDNLYEIDEVRPILERAAELTGKRYGAQSGQAANQSHPDDVRLRVVADHVRTALMLIGDGVTPSNEGRGYVLRRIMRRAIRAVRLLGWQERALPELLPVARDCMAPSYPELATDFDRISAYAYAEEDAFLATLRAGTTILDTAITETKSAGKPALSGDKAFQLHDTYGFPIDLTLEIAAEQGLDVDQEGFRRLMADQRARAKADAQARKTGHTDLSAYRSVLDAGGPVTFTGYTETARESTVRAVLGTDGPRAAAVEGDMVELVLDTTPFYAEGGGQQPDLGMITVGGGQVEVLDVQQPVPGLIVHRARVIRGEVRAGETGYAEIDTSRRRAISRSHTATHLVHQTMRNFLGESATQAGSLNAPGRLRFDFNTATGVAPSVLRDVEQQVNEVLLADLEVHAFVTSLDEARRIGAMALFGEKYGDQVRVVEVGDYARELCGGTHVSRSGQLGLVKILSESSIGSGVRRVEALVGMDAFNFLAREHLLVSRLAELYRVPSEQVADRVEQTVTQLRDAEKELEKLRAQLVLGGAAAFAAQAKDVRGVAYVGIEAPEGAAGNDVRTLAQEIRGRIDAARPGVVAVASRSNGKASLVVSVNPAARSRGLAANDLVKAAFSGRGGGSPDLAQGGGLPESEVPTLLLTVEKAIAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3V3</accession>
    <name>F4F3V3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_21520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734057.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21520"/>
    <dbReference type="EnsemblBacteria" id="AEB45404">
        <property type="protein sequence ID" value="AEB45404"/>
        <property type="gene ID" value="VAB18032_21520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21520"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OMA" id="VRCMPPE"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="366" mass="39095" checksum="606E64A1847D83DD" modified="2011-06-28" version="1">MALGNVGGYTLVEPLGCGGMGDVYFAISPIAQRVALKVIKKHLIAAPTIRERFASEVESLKLVFGSRVARLEDADATGDPAWLAVEYVPGATLREYVDARGPLPLPLAAMAGAMLAEGLAKVHQAGLLHRDLKPQNIILGPDGPKLIDFGLAVLIDRSDYLTAPGAMVGTPAYMSPEQVRGERKLTPAVDIYGLAAVLVFALTGHALYPPTNSWNLLLRITEPSDLPDLSGVPAELVPLLGAMLAFDPSARPALADVQARLLAVATATSGRTVHDLRQEVAARTYDSATELLVPPDLQDPKQDPEDPPVVASERADDRAVEERSTVAVPEPAPTKVDPERVGSGPPVDVTWLVEKLRRQYARRTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F412</accession>
    <name>F4F412_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735308.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27926"/>
    <dbReference type="EnsemblBacteria" id="AEB46658">
        <property type="protein sequence ID" value="AEB46658"/>
        <property type="gene ID" value="VAB18032_27926"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27926"/>
    <dbReference type="eggNOG" id="ENOG50322X6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026521_0_0_11"/>
    <dbReference type="OMA" id="IFRAWHA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="27680" checksum="736F5286DA9C2944" modified="2011-06-28" version="1">MTTARPAPRPITRSGDGEVGLRRTRAAALRAVTAYRGLSWTPLLLVGAGLGLFAFVGDELPGIAGMVVLTLTSTGFAWGGAALLAGYLTTSGAVAPISRAVAPISASVVLVTATVVYYGLIVAHGRRWRLGTLEDGSSSALNGLASVGRATAFWLTASVVAGVLLGGLGALVRRGTRIAASVAAGAALGLLAGQGLEFLMIFRAWHALDAFFLGRVLSATASVLLAMIGTTVLLAYRRAPTSWPIFAATSLLASLVAALLWHQIGSITTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4J2</accession>
    <name>F4F4J2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate pyrophosphohydrolase</fullName>
            <ecNumber evidence="3">3.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731621.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09160"/>
    <dbReference type="EnsemblBacteria" id="AEB42950">
        <property type="protein sequence ID" value="AEB42950"/>
        <property type="gene ID" value="VAB18032_09160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09160"/>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_3_0_11"/>
    <dbReference type="OMA" id="HWLRTKA"/>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312684" evidence="1">
        <location>
            <begin position="23"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="136"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="34223" checksum="8BC275CF5779C62C" modified="2011-06-28" version="1">MPRIVLLVTSPRLPAGLLTAAAWDVVRTAVVLAGAESELATAIRSAGGQVRVPDGPAVPALLDAAVAHDTVVWLAGPAGDEALARELGLRLAREPGLAEMELMYGSWDPPGARLLDAVAVLDRLLSPGGDPWKRAQTHQSLAGFLLEECYEAYDAIVASDTDSLREELGDVLLQVVLHARLAEELPEGERWTIDDVAGGLVDKMIRRNPHVFAGAEAGSLEEITANWERIKQAEKARKSVLDGIALSQPALALATQILDRATRANLTAPLPTPESQPTPEQTLGATLLSTVAEAHQAGLNPESALRHTTLTYAKTLPTPTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4L3</accession>
    <name>F4F4L3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732820.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15215"/>
    <dbReference type="EnsemblBacteria" id="AEB44155">
        <property type="protein sequence ID" value="AEB44155"/>
        <property type="gene ID" value="VAB18032_15215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15215"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_11"/>
    <dbReference type="OMA" id="QVRHYTY"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="341" mass="37628" checksum="83A833CC9163F66F" modified="2011-06-28" version="1">MAKVLVTGSAGFIGGYLVAELLDRGHEVVGVDNFSKYGPVSHSYDTHPRFRFVEGDARDTDLLTELLDGCDHLVAGAAMIGGISYFHAYAYDLLATNERIMAATCDAALRAHRDGTLRKVTYLSSSMVYESTEHWPSREGDERRIPPPLSSYGFQKLAVEYYARAAWEQYQLPFTIVRPFNCVGVGEGRALGQAEVLSGNVKLAMSHVVPDLVQKIVKGQDPLHILGEGDQVRHYTYGGDLARGIATAIEHPAAHNEDFNLSTARSTTVLELAELIWHKIKGAEVPFRYVSDEPFRYDVRKRVPDTTKAAEVLGFTATTSLDTMLDEVIPWVTDAVHAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4T7</accession>
    <name>F4F4T7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45426">
        <property type="protein sequence ID" value="AEB45426"/>
        <property type="gene ID" value="VAB18032_21630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21630"/>
    <dbReference type="eggNOG" id="COG2388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132888_0_0_11"/>
    <dbReference type="OMA" id="QRVFFHT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="11133" checksum="F3E4C96309D89E3F" modified="2011-06-28" version="1">MVVVTDVPEAKRYEARLDGESEVAGIAEYIRTAELVAFVHTEVSPKYEGRGVGAALARAALNEARAANLRVLATCPFIAGWIDRHPEYQDLLYQARSRVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4T9</accession>
    <name>F4F4T9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21640"/>
    <dbReference type="EnsemblBacteria" id="AEB45428">
        <property type="protein sequence ID" value="AEB45428"/>
        <property type="gene ID" value="VAB18032_21640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21640"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773004_0_0_11"/>
    <dbReference type="OMA" id="HEHIRIA"/>
    <dbReference type="OrthoDB" id="1028228at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="371" mass="38701" checksum="90F88FE10409BB86" modified="2011-06-28" version="1">MRFVVSVPDEVSAYAVAEKLAERGHLLVAVREVPTDPLEDRFAGWWRAHSLAVDPPYEGLLEVSPAEKKAVAAIARKYGGQVNSACGQFPDKAIERFSREGLAYELDRAEADRIRAELVGGQTAAAPSLPAPPGLRCGGFRRPAADLRAAVEVVPFEGRTFDGVGDLIAAIANDAFPQGSVVPATPGAVPLLAALAGADGVSDFYRAMTLMVLFQMSTAGRRRLAYQADAPEDGGAETPAETATRAAVAAVLPGLAVGRSELVEFLLAGLSAATREAGAGMPAGLERIAGRYAGTARSPVVDLIRAVADGAEEPIRTATAAVVAALPEVVDGVQSTKATVEGRALDTLDTVLQWELDNARLPKLGTVFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F587</accession>
    <name>F4F587_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735418.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28491"/>
    <dbReference type="EnsemblBacteria" id="AEB46769">
        <property type="protein sequence ID" value="AEB46769"/>
        <property type="gene ID" value="VAB18032_28491"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28491"/>
    <dbReference type="eggNOG" id="COG5637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128067_0_0_11"/>
    <dbReference type="OMA" id="WAWTRVA"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="23731" checksum="090C1B360DA717A4" modified="2011-06-28" version="1">MTTSNGARWALLGAATVTAIGVGRAVARRRHRHQPVKQDGWYVVRRGVTIDRPVEAVIGFWTDQERLDRALAEWATLERIDDEHWRCVALDDSGAGVEWRAEITVTGPGRLSWQVTDGPEQQGTVKLVTAPQGRGTEIRAELRYRSGPLRRALGLAGDHEPDLRLRDTLRRVKSLIECGQIIETRRDPSGRGRMQERATDKVRERLSAGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5J6</accession>
    <name>F4F5J6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_09550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731699.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09550"/>
    <dbReference type="EnsemblBacteria" id="AEB43028">
        <property type="protein sequence ID" value="AEB43028"/>
        <property type="gene ID" value="VAB18032_09550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09550"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_3_0_11"/>
    <dbReference type="OMA" id="FPMFVWG"/>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="30579" checksum="17E775513DCEEDB3" modified="2011-06-28" version="1">MSRVSRWFAQHWVMGVALLVLGYLFLPIAVVAALSFNRPSSRLSYDFNEFTLDNWRNPCATSDMCDAVLRSAQIGFLATVAATALGTLMAFALVRHRFRGRSGLNVLIFLPMATPELVMGTSLLALFVAGGVPLGFWTIVIAHVMFCLSFVVVTVKARLAGMDRRLEEAAMDLYASEWQTFRRITLPLVLPGIVAAALLAFSLSFDDFIITNFNSGTTVTFPMYVWGAAQRGIPPQVNVIGTAMFAIALLLVLATMLRGRRVRRSAITAAVPAPRAASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5L8</accession>
    <name>F4F5L8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44231">
        <property type="protein sequence ID" value="AEB44231"/>
        <property type="gene ID" value="VAB18032_15595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15595"/>
    <dbReference type="eggNOG" id="ENOG50333HP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168323_1_0_11"/>
    <dbReference type="OMA" id="TEDDFMI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="96" mass="10749" checksum="31751AE266141EEE" modified="2011-06-28" version="1">MDGSLGAVTEDDFMIRLSRDEALVFSDWLHRMMGTADFDELVDRDQAVWSPLYRISGTLETSLAEVFRPDYPVRLQEARNRLLDALGGVGRATGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5X4</accession>
    <name>F4F5X4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_22165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22165"/>
    <dbReference type="EnsemblBacteria" id="AEB45533">
        <property type="protein sequence ID" value="AEB45533"/>
        <property type="gene ID" value="VAB18032_22165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22165"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070456_1_2_11"/>
    <dbReference type="OMA" id="ASAYREW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="246" mass="27329" checksum="4E343153F80406A9" modified="2011-06-28" version="1">MDKWVSIATPNPAAPTRLFCFPYAGGGASAYREWHRWLPQVEVAAVQLPGRENRLGERPVAAMDRLLDLLVEALDPLLRQRPFAFFGHSMGARIAYALTRRLEQDGAPLPSWLFASGSPAPWLRIPEAAWAEPDDRLLAWLADLGGTPPEVLDSPDLMQLALPVIRADLTLGATWQYPYTTPSSVPVHAFAATDDDYATPERARAWERETTGPCRVSVFPGGHFFLHEHTAQILRLIDEDLLSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F4F635</accession>
    <name>F4F635_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">valS</name>
        <name evidence="14" type="ordered locus">VAB18032_28581</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735436.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28581"/>
    <dbReference type="EnsemblBacteria" id="AEB46787">
        <property type="protein sequence ID" value="AEB46787"/>
        <property type="gene ID" value="VAB18032_28581"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28581"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_11"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="28"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="609"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="13">
        <location>
            <begin position="806"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="811"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="527"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB46787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="872" mass="96517" checksum="4DDF353CD6A8E17D" modified="2011-06-28" version="1">MTENLDTRRPDAPTIAGQYQPGEVEQRRYEQWVADGRFRASADSDKPPFTIVIPPPNVTGSLHMGHALDHTVQDALVRRKRMQGFEALWLPGMDHAGIATQNVVERQLAAQGLSRHDLGREKFVERVWQWKAESGGAILGQMRRLGDSVDWDRERFTMDEGLSRAVLTMFKKLYDDGLIYRANRIINWCPRCLTALSDIEVEHSDDDGELVSIRYSDDVVVATTRAETMLGDTAVAVHPDDERYRHLIGTEVELPLTGRRIPIVGDAHVDPAFGTGMVKVTPAHDPNDFEIGQRHDLPALTIMDERGVITAPGPFEGLDRFEARPAIVAALRAEGRIVAEKRPYVHAVGHCSRCRTTVEPRLSLQWFVNTSPLAKAAGDAVRDGRVAIEPADLAKRYFAWVDNMHDWCISRQLWWGHRIPVWYGPNGEVVCVGPDEQPPTGEGWHQDEDVLDTWFSSGLWPFSTLGWPEQTPELAKFYPTSVLVTGYDILFFWVARMMMFGLYAMDGKQPFDVIALHGMVRDEHGKKMSKSFGNVVDPLDWIDRYGADATRFTLARGANPGGDVPVSEDWCQGSRNFCNKLWNATRFALLNGAHTAGALPGAAELSTVDRWILSRLAQVTAEVDEQFEAYEFAKVCDLLYHFAWDDVCDWYVELSKPVLAAGGAAADTSRRVLGHVLDQLLRLLHPVIPFVTEELWTALTGGETVMTAAWPVADRARIDTGAEAEIATLQRVVTEVRRFRSDQGLRPTQRVAARLDGLAGAGVAAHEPLIRSLARLDAAGDDFQASATLAMPGEVSVALDTRGSIDVAAERARLTKDRAAAEKEAGQARAKLDNPAFVGKAPEPVVAKIRDRLAAAEADLTRIDAALEALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F690</accession>
    <name>F4F690_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="11">NN:DBI PRT</shortName>
            <ecNumber evidence="5 11">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobT</name>
        <name evidence="13" type="ordered locus">VAB18032_28856</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5 11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28856"/>
    <dbReference type="EnsemblBacteria" id="AEB46842">
        <property type="protein sequence ID" value="AEB46842"/>
        <property type="gene ID" value="VAB18032_28856"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28856"/>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002982_0_0_11"/>
    <dbReference type="OMA" id="AIWYAGW"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB46842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="375" mass="37517" checksum="8B6C7EC90AE58F6C" modified="2011-06-28" version="1">MMLETTIAAIGPLDEAAMSTARQLQTRLTKPAGSLGLLEELSVRLAGLAGTCPPPLPSPAAVAIFAGDHGVHAQRVTPWPQEVTVQMVGNFLAGGAVVNAFARQAGATVTVVDVGVATPLPTSDDHPPTGDAPVAAPGGVRGHGRVDVPRLVDANVRRGTRDMTVTAALTRDEARSAVEVGIRIAGELIDGGAALLVTGDMGIANTTPAAALIAAFTGVDAAEATGRGTGVDDPTYQHKIEVVRAALLRHTPDPTDPLGVLAAVGGLEHAALTGLLLGAAARRVPVLLDGVIAVSAALAAAALAPDAVGAMIAGHRSAEPGATVALRQLGLTPLIDLGLRLGEGTGALLALPVVTGAVRVLHEVATFDSAGVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6E5</accession>
    <name>F4F6E5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, arac family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731762.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09865"/>
    <dbReference type="EnsemblBacteria" id="AEB43091">
        <property type="protein sequence ID" value="AEB43091"/>
        <property type="gene ID" value="VAB18032_09865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09865"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="OMA" id="GIDCCLH"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="35659" checksum="7844705FC17F068C" modified="2011-06-28" version="1">MTPHRIAVLAVDQVVGLDLGTPSQVFRTARNADDQHLYTVDTCTPGGRPVRSTAGFQVLPDHGLELLADADTVIVPGVNGDATRRRDVIEPEVIEALRAAYDRGVRVMSICTGAFVLAAAGLLDERRATTHWAYTDRFRELYPKVDLDPEVLFVADGPVLTSAGVAAGIDLCLHVVRTDHGSQVANQSARRCVMPPWRDGGQAQYIERPVPQAPDTSTAGARQWARQRLHESVSLRDLAEQARMSVRTFTRRFRAETGLSPAQWLLRERTDHARLLLESTDLSIDQVARRSGFGTAAALRQQLHQRVGVAPSAYRRTFKGRAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F713</accession>
    <name>F4F713_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA polymerase, sigma-24 subunit, ECF subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_29031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735526.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29031"/>
    <dbReference type="EnsemblBacteria" id="AEB46877">
        <property type="protein sequence ID" value="AEB46877"/>
        <property type="gene ID" value="VAB18032_29031"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29031"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_1_11"/>
    <dbReference type="OMA" id="VQWPEQG"/>
    <dbReference type="OrthoDB" id="1469807at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="407" mass="44803" checksum="F734CBFC33BD9F51" modified="2011-06-28" version="1">MQDLLRGLVPQVLSVLVRRYGDFDACEDAVQEALLAAVVQWPEQGMPDFPLAWLITVASRRLTDLRRSEAARQKREVNSAALTPRDEFVAAGPGDDLPHGDDTLILLLLCCHPALSRPAQMALTLRAVGGLTTAQIASAFMVPDATMSQRISRAKRQIKAAGATFQMPTGADLHERLRVVRHVLYLIFNEGYTATSGPDLRRPDLTREAIRLTREIHRLLPDDGEVAGLLALMLLTDARSPARTGPDGALIALADQDRSRWNQDQIAEGVHLVTGTLSNAPIGPYQLQAAIAALHDEAERAEDTDWPQILVLYDLLEQVWPNPVVRLNKAVALAMAHGPRRGLELLATLDSDERLAGSHRLLAVRAHLLELAGDRRAALEAYEAAARRATNLPERRYLEARATRLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F714</accession>
    <name>F4F714_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter multidrug efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_29036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
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    <sequence length="484" mass="49594" checksum="68A1C3611D63B34B" modified="2011-06-28" version="1">MANPLTSAAPAHAEQPDTRRWLALILLCTANFMVILDSQIVIMALPPISEALHLTPEAAQWVINANLLTFGGLLLLGGRLADLLGRRRIFILGTVLFLLVSVASGLAPNAEVLIAARALHGVSAALMAPTALSILSTTFAEGAPRNKALSLWAGIAGIGAVTALLIGGALASIGWQWIFFVNVPVALIMLVISPLLLRESRDAGIPRTYDVAGALTSTTGLVLLVYAVVVAPVQGWLSPVTLGLIAASGVLFALFVVIERRSSAPLVPLNIFRKPNLTGGNLAMVTMGMLAFGFSVTISQYSQIVLGLSPLEFGLRQAIMPAMAFIGAYVGQRFVTRLGFRPVAAVCLVLLGAGSLIMALTATGSMSYGATFLALVPFGVGLGLGTTAASAAALSGVAYSESGLASGFNTAAQQVGGGLGVAVVLTVIASYAPAVASPTAGFQAAFAACVVFAIVGLVITLTMMRSKRATDAALAAPTPALNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F805</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="AEB46980.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="21134" checksum="95B5AC3E6BB2D656" modified="2011-06-28" version="1">MALDTAELLLHPVRMRIVQAFLGGRTLTTTDLRAELADVAPATLYRQVATLTGHGVLRSVGERRIRGAIERSYQLDEAAAAVDADTIRGMTPEQHRRAFLTFIAGLLADFDSYLDSGGGDLARDLAGYRQNAFYATDAELVEFITRMRELFAEYAALGPGPGRTRRLFTTVLLPADPVTAQDDGDAPSEATSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F847</accession>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
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    </feature>
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            <end position="348"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="388"/>
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    </feature>
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        <location>
            <begin position="330"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="427" mass="44891" checksum="E9E33647763D6137" modified="2011-06-28" version="1">MTAGHGESFLRKFGKFFTGNLLRTLAQGVLFVLLAREMPIDTYGLFVGVTALIAVVSPFASAGAPSLIIQNYADSPADWPRHLCRGLFLSTVFGGAATVLVSAAGLAIWGAQIGLVDLLCLAFADLVAWRLIEAVAASFHVRGRIMLAALIPALLHVCRLAGAAVLALSDEPVTLRGWATTSVVISVVVCLPVLLAGLSGAAVASLGVGGALRQARTGMLFAVGLSAQSVYNDSDKVMLSRLGTPESAAIYAAAYRVVDLAYTPARTMGAVAYPGFFEAGRNGPREALRMARRLVPRFLAFSVPVSLLLVAFAWMMPLVFGPDFEAAIPALQGLSALLVLKSLHYLAADALSGARMQGRRTICQIGIGVLNALLNLWLIPVYGWQGAVVSSLVCDALLAVLLWGCLAAAVRRDRAGAPPSPHSMERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F868</accession>
    <name>F4F868_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_10555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10555"/>
    <dbReference type="EnsemblBacteria" id="AEB43229">
        <property type="protein sequence ID" value="AEB43229"/>
        <property type="gene ID" value="VAB18032_10555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10555"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034641_2_0_11"/>
    <dbReference type="OMA" id="YFTYPPF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="44257" checksum="7BCBDABA55DFA686" modified="2011-06-28" version="1">MLVVAAALPALYLPGRVHNFFDLKIYMSAMDWWSAGNPLYDYVQPDRVQGELYFTYPPFAALLLLPFGHLTLGVTVAIFTGLTLLGVLVTTKWLLDPVIRRHRLPYLFTLAVGALFVLGVESTRETITFGQINMLLVVLILADLLFAVPRDSRWAGVGIGLAAALKLFPGIFVVYLLATRRWRAAAVAAATAAGATLLAAAVAPGDSWRFWTHELWATDRVGRTDYTGNQSLFGLLSRLSAPEDPSRLIWLPLVAAIVGYGLWRAVRASQAGDALTGLTLTGLVAALISPITWTHHIYWFIPAVVILIDATLSTDPRTAEGARRRRRLAAVAVGTSAIIVYGVVSFYDWGIAPTPTDTPWEFVGRNAYVLLCLLLLAVLPIRTRTGTKPTKSPHPTTHPKTPIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8F1</accession>
    <name>F4F8F1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase, zinc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733151.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16960"/>
    <dbReference type="EnsemblBacteria" id="AEB44496">
        <property type="protein sequence ID" value="AEB44496"/>
        <property type="gene ID" value="VAB18032_16960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16960"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="OMA" id="VWYLLHK"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="33348" checksum="90EEB73C91FE9CD9" modified="2011-06-28" version="1">MRVVHAMRFGGPEVLVPGEMPDPVAGPGRVVVEVAVAGMTFVETQIRRGADRWHERPRLPYVPGGLVAGLVSAVGAQVDPAWLGRRVVASTGETGGFAERAVAMVGDLFPVPDGLGLPEATALYSDGSTAQGLAEHATPGPGDWVLVEAAAGGVGSMLVQLARAAGAQVVGAARGSRKLDLVRDLGADAVVDYSEPGWTTRVREATGGAGPDVVFDGVGGEIGRAAFDVTARGGRFSVHGAASGEVTVIDPVKARHKGVTVIGIEQLFGFAPHLRRWAARMMSQAAEGVVRPIIGQTFPLERAAEAHAAVENRTAVGKTLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8I1</accession>
    <name>F4F8I1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44526">
        <property type="protein sequence ID" value="AEB44526"/>
        <property type="gene ID" value="VAB18032_17110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17110"/>
    <dbReference type="HOGENOM" id="CLU_1501860_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="20543" checksum="1816BB3C8DF9474E" modified="2011-06-28" version="1">MITDDDVEIEPAQPRRRLRDLGRPLVVLMAPVLVRLANRDTRFVWTLGEVRGHARDWPPSGGDAEMANLFRFQAWFGLSVVPLAGYVAASLLRSGSAGDSVLEAVMVGAATVGMFTLGMVLVSGLKWGLSQYFTPDLDRRLGPPRRRDPRPRTRRPGFVVRLCLPSNLDWVLALVFASCMAPNAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8J1</accession>
    <name>F4F8J1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733191.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17160"/>
    <dbReference type="EnsemblBacteria" id="AEB44536">
        <property type="protein sequence ID" value="AEB44536"/>
        <property type="gene ID" value="VAB18032_17160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17160"/>
    <dbReference type="eggNOG" id="ENOG50344BX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160711_0_0_11"/>
    <dbReference type="OMA" id="TRAYVIA"/>
    <dbReference type="OrthoDB" id="1961799at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="239" mass="26130" checksum="90B3C1D46B71E877" modified="2011-06-28" version="1">MTADSVPTSGDPRQLLSEVRALARRVRLDQRVTWVALLVLAAVTFVAIPIDWYSLRADCGSASAWVTDVNDGSWCHVRRDGAMFYWPPALLLAYTAIAVYAVRVARSRGLGVRVLPYVITGVALTVLFTVLWLLARLYLAGPAPTQPLPSWVMLLDRLVAPAGAIGVALLVLAWLERHVALLVFTLGYLAVVLVPINIFWHPDWGYAGILGEFLPPQIVNGAVLLLGAVGFAVARRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8K6</accession>
    <name>F4F8K6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23255"/>
    <dbReference type="EnsemblBacteria" id="AEB45749">
        <property type="protein sequence ID" value="AEB45749"/>
        <property type="gene ID" value="VAB18032_23255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23255"/>
    <dbReference type="eggNOG" id="ENOG5032RUB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131973_0_0_11"/>
    <dbReference type="OMA" id="RHFWIAN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="142" mass="15386" checksum="23D70716C838F8CE" modified="2011-06-28" version="1">MTHEEKRAWIMLVVSVIAYAGYVAVVLGRHDGGSLTAVPYVGALLWTVGGAMVASIVAEIGMGMASPRASRVKDDRDREIGRLGDHVGHAFVVIGAVSALLMAMAEWDWFWIANVIYLCFVLSAVIGSLAKVIVYRRGVPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8P1</accession>
    <name>F4F8P1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin b12-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23430"/>
    <dbReference type="EnsemblBacteria" id="AEB45784">
        <property type="protein sequence ID" value="AEB45784"/>
        <property type="gene ID" value="VAB18032_23430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23430"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069063_0_0_11"/>
    <dbReference type="OMA" id="WRVDFLG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="96"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="352" mass="37474" checksum="BD43EAE89A7FF6FC" modified="2011-06-28" version="1">MTMATTGISPAALYPRYLHCLAEADEPAAVEVARELLDAGVPADRVLLDLVAPAQAEVGERWARNEWSVAQEHAATHVSERVVAAIAAYANPRGDRGRIVVACMDGEWHALPARLVAEVLRLRGWQVTFLGASVPAAHLVSYLHRHDAYAVALACALPMRLPQAHRMIEACQRSDVPVVVGGRGFGADGRWARRLGVAWAPDGPTAADLLGDERVLRAVAPADLAHLADDEYAGLVGRRGELIDSALADLAQRMPGFGDYTPAQFDSTVSDLGYILDFLAAALYVDDGSLFTEFVEWLVTILASRGVPAAAVGATLRHYAGVLHDFPRAGAYLRAGGASLPAAGRRPLPSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8U4</accession>
    <name>F4F8U4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29766"/>
    <dbReference type="EnsemblBacteria" id="AEB47024">
        <property type="protein sequence ID" value="AEB47024"/>
        <property type="gene ID" value="VAB18032_29766"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29766"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083278_0_1_11"/>
    <dbReference type="OMA" id="FAGRSTH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="20103" checksum="C9B51EEB37167463" modified="2011-06-28" version="1">MLVAMARPAPQTHDEILAAAARRFGVTGYRGTSLQDIASEVGCSKAAVLYHFANKEAILTELMAPAIEALRTLDERIVAQSDPEGAQRAAAEGFVDLAVRFRAEIALLRGEFPNLLQQPGFTHIQQISERLLDALAARSERPSARVAAFVLVAGIAETCGEFADVPDDELRDALLALLRRALEPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F913</accession>
    <name>F4F913_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730715.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04575"/>
    <dbReference type="EnsemblBacteria" id="AEB42041">
        <property type="protein sequence ID" value="AEB42041"/>
        <property type="gene ID" value="VAB18032_04575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04575"/>
    <dbReference type="eggNOG" id="ENOG50332KG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143968_0_0_11"/>
    <dbReference type="OMA" id="MAVPQRI"/>
    <dbReference type="OrthoDB" id="1687192at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="14303" checksum="D58C81BBDA3BE41D" modified="2011-06-28" version="1">MALRGGTRFSVPFAAVFPHGAVFVPDSIAEAQDFNEATRQRTPSKDKVTGQRVWQCRVMDMDPELGARSREVSIKILADVQPVPPVGPFQPVEFEGLTVTPYVGSNGRLAFSYRATALVAPKTLAETRGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9A6</accession>
    <name>F4F9A6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43300">
        <property type="protein sequence ID" value="AEB43300"/>
        <property type="gene ID" value="VAB18032_10910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10910"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097583_0_0_11"/>
    <dbReference type="OMA" id="TWLGQWP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="219" mass="23949" checksum="955F597183A7F22D" modified="2011-06-28" version="1">MRDRRLQLHLATWLGRWPAPAGLHVVGSWRRSQPAWDGRLRPAIAVTAGASTVLSVPTDRVAAVRDLARRPDTLLPTLPAAVGEPGWAVHDDVFRWTMAPAPLPEVGEWVAPTILGLPSWLRLFDRPVLVVRDDQGRYLAGVGIKRHDHFGHELAVGTVPSARGRGLARRLVAQAARRVLDEGAVPTYLHDRANAASARVAEAAGFPDRGWRSYGVYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9C9</accession>
    <name>F4F9C9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Electron transfer flavoprotein alpha/beta-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_11025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731994.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11025"/>
    <dbReference type="EnsemblBacteria" id="AEB43323">
        <property type="protein sequence ID" value="AEB43323"/>
        <property type="gene ID" value="VAB18032_11025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11025"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_0_11"/>
    <dbReference type="OMA" id="YNGGMVP"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="4">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="27209" checksum="061898669E2ABD94" modified="2011-06-28" version="1">MNIVVLVKQVPDSGADRNLRSDDNTVDRGSANNVINEMDEYAIEEALKIKEAHGGEVTILTMGPDRATESIRKALSMGPDKAVHVVDDALHGSCAVATSKVLAAALGQLNADLVLCGSESTDGRVQVMPHMLAERLGVAALTGARKLTVDGSTLTVERQTEEGYEVVTATTPAIVSVWDTINEPRYPSFKGIMAAKKKPVQTLSLADLGVAADEVGFAGATSAVVEHSKRPPRSGGAKVTDEGSGGVQLVEFLATEKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9D4</accession>
    <name>F4F9D4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase c60 sortase a and b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731999.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11050"/>
    <dbReference type="EnsemblBacteria" id="AEB43328">
        <property type="protein sequence ID" value="AEB43328"/>
        <property type="gene ID" value="VAB18032_11050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11050"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062592_3_1_11"/>
    <dbReference type="OMA" id="MTHRLIT"/>
    <dbReference type="OrthoDB" id="1771853at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312821" evidence="3">
        <location>
            <begin position="38"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="23190" checksum="23E2BE3DFB684635" modified="2011-06-28" version="1">MSKVNRGALAAVAAGATALAVAAVLAVVSRPDGSVGADQAAALAEPSPSAGASSLGASSAGSTPVPVAPGALPGDTGTVPPVRLRIPAIDVTARVDPVGVDRRTGEFDVPPSVDQVGWYRYGPGLAAETGSVVIAGHVDSAEQGRGAFYRLRDLAPGDTLTATGDDGIERTYRVVAREEYDKTKIPLARYFARDGRPRLTLITCGGPFDAEARRYRDNIVVTAVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9G5</accession>
    <name>F4F9G5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ordered locus">VAB18032_11205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732030.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11205"/>
    <dbReference type="EnsemblBacteria" id="AEB43359">
        <property type="protein sequence ID" value="AEB43359"/>
        <property type="gene ID" value="VAB18032_11205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11205"/>
    <dbReference type="eggNOG" id="COG0059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_0_1_11"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="OrthoDB" id="188901at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="184"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AEB43359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="36070" checksum="DE59A74CD771BC78" modified="2011-06-28" version="1">MSVEVYYDDDADLGLIQAKKVAVIGYGSQGHAHALSLRDSGVDVVIGLPEGSKSRPKAEEQGLRVLTPADAAAEADVIMILAPDTAQRHIYAESIAPNLSAGKALFFGHGFNIRYGLIKPPADVDVAMVAPKGPGHLVRRQYVDGKGVPCLVAVEQDASGTALALALSYAKGIGGTRAGAIKTTFTEETETDLFGEQAVLCGGAAALVQTGFEVLTEAGYAPEVAYFECLHELKLIVDLMYEGGIARMRYSVSDTAEYGDLSRGPRVIDSRVKDEMRKILGEIQNGEFAREWVAEDEAGRPNFSKWQAEGAAHPIEETGAKLRGMMSWVDRPITETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9U4</accession>
    <name>F4F9U4_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">VAB18032_23860</name>
    </gene>
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        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB45870">
        <property type="protein sequence ID" value="AEB45870"/>
        <property type="gene ID" value="VAB18032_23860"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG5033DN8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1223580_0_0_11"/>
    <dbReference type="OMA" id="VWPLELR"/>
    <dbReference type="OrthoDB" id="1997168at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="23826" checksum="EA7486E5971DAB28" modified="2011-06-28" version="1">MSGPGPIEGATADLAAWLAGAAGAAVPVGPPGPDTDPGGLTLWPLELRPVRQTRGSGAAEPYRFTVRYLLAVGGPDALAALDRVLVAATTTGTRTLTLEAGDPTLWTAFGTPPRPALLIDVPVQITPAQQPAAPVLHPLRLRQLDMLTFDGRVVGPAEQPLAAMRVEVVGQAYATRTDPAGRFRIVGVPHDPEQPGPVRLRLTGRGQVLTAEVDPTEPDIVIVCAPPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA20</accession>
    <name>F4FA20_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00235"/>
    <dbReference type="EnsemblBacteria" id="AEB47131">
        <property type="protein sequence ID" value="AEB47131"/>
        <property type="gene ID" value="VAB18032_00235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00235"/>
    <dbReference type="HOGENOM" id="CLU_3105120_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="51" mass="6086" checksum="1F3A3D9C8B186C0A" modified="2011-06-28" version="1">MINNNNERIRIRRQMQRRIRDVVAERRRERLLETAPEPADEPATDSQLTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAB8</accession>
    <name>F4FAB8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_05265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730853.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05265"/>
    <dbReference type="EnsemblBacteria" id="AEB42179">
        <property type="protein sequence ID" value="AEB42179"/>
        <property type="gene ID" value="VAB18032_05265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05265"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_11"/>
    <dbReference type="OMA" id="WRAAWMG"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="254"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="43656" checksum="27B246919FA44FB2" modified="2011-06-28" version="1">MVEFSLDLNEEQRDLRDWVHGFAAEVVRPAAAEWDAREETPWPLIQEAAKVGLYGFEFLATCWADPTGLSLPIASEELFWGDAGIGLSIFGTGLAVAAIYGTGTPDQLVEWVPQCFGDVDSPAVAAFCSSEPEAGSDVGAMRTRASYDEATDEWVLRGQKAYATNGGIAGVHVVVASVDPELGSRGQAAFVVPPGTPGLSATRKLRKLGLRASHTADVFLDDVRVPGRCLLGGKEALDERLARARAGKRASGQAAMRTFELSRPTVGAQALGVARAAYEYALDYAKDRVQFGRPIITNQAVAFTLADMKMEIDAARLLVWRASWMGRNNRPFTAGEGSMSKLKAGEVAVSVTEKAVQLLGGAGFLRDHPVERWYRDAKIYTIFEGTSEIQRLVISRAISGMQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAH7</accession>
    <name>F4FAH7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">coaD</name>
        <name evidence="8" type="ordered locus">VAB18032_11450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11450"/>
    <dbReference type="EnsemblBacteria" id="AEB43404">
        <property type="protein sequence ID" value="AEB43404"/>
        <property type="gene ID" value="VAB18032_11450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11450"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_11"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="5"/>
            <end position="6"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="118"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="158" mass="17354" checksum="3051660AB875640F" modified="2011-06-28" version="1">MCPGSFDPVTNGHLDIVGRASRLFDEVIVGVLINQSKTGLFTVEERIAMLREVTASYDNVRVESFRGLLVDFCRAQQASVLIKGIRAVSDFDYELQMAQMNIGLAGVETLFMPTNPLYSFLSSSLVKDVAKWGGDVTPHVPDIVREALKTRLTPPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAR5</accession>
    <name>F4FAR5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733335.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17890"/>
    <dbReference type="EnsemblBacteria" id="AEB44680">
        <property type="protein sequence ID" value="AEB44680"/>
        <property type="gene ID" value="VAB18032_17890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17890"/>
    <dbReference type="eggNOG" id="COG3371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094600_1_0_11"/>
    <dbReference type="OMA" id="NNDIWGH"/>
    <dbReference type="OrthoDB" id="1962568at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="20546" checksum="C7623DE37255BE0A" modified="2011-06-28" version="1">MVLWAGAAAAVLFVLVFLVDGGSRPHYASARHPVSALALGSRGWIQTANFVVCGSAITAGAVAVIVEGPRVLLGVVLSIFGLGLVASGVFRMDPMLGYPPGAPAGIPEQHSTAHRVHDIAGAVVFLSLPLAAAISAFTLSATSWRVTSGCVAVALFLGLGQFGRAWERVSPRIGLIQRAVIIPGWGWLAALFTALALGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAT1</accession>
    <name>F4FAT1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17970"/>
    <dbReference type="EnsemblBacteria" id="AEB44696">
        <property type="protein sequence ID" value="AEB44696"/>
        <property type="gene ID" value="VAB18032_17970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17970"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047971_1_0_11"/>
    <dbReference type="OMA" id="RYNIAMI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="458" mass="51131" checksum="F2DF7E5F8A6DB572" modified="2011-06-28" version="1">MELHRLAVAGREPEIARDVGDRVARLWLRTSRFADVEALANATLTLGPDADALYNLGWAQTVIGQPRHALKSYEQALHLYREADDRGNEAAALNSIGLVHDVLGDREQALTYYQHALPIRREVGDRAGEATTLNNIGAVYDELGDRQQALTYYQQALPIRREVGDRAGEATTLNNIGHTYHGLGDRQQALTYYQHALPIRREVGDRAGEATTLNNIGNVYDELGDRQQALTYYQQALSIQRDVGDRAGEARTLNNIGLVHDELGDRQQALTYYQQALPIRQQVGDRVGEATTLNNIGAVYDVLGDREQALTYYQQALPIRQQVGDRVGEATTLNNIGLVYKELGDRQQALTYYQQALPIRREVGDRVGEAVTRYNIAMIHRDEGNLDKAIGELELVVELDRQVGHPDFASDTAMLEQLRQDRTARARINPLVSETAEHRVTTWIGKLKAKFNNSGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAV4</accession>
    <name>F4FAV4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide/dipeptide abc transporter, atpase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734569.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24095"/>
    <dbReference type="EnsemblBacteria" id="AEB45917">
        <property type="protein sequence ID" value="AEB45917"/>
        <property type="gene ID" value="VAB18032_24095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24095"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="AFIMQNP"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="8"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="346" mass="36375" checksum="7BAF10C0E8C2B8E7" modified="2011-06-28" version="1">MTTTDPLLAVAGLTVRFRLPDAVVHAVTDLHLDIRPGELVAVVGESGCGKSVLAHALLGLLPRNATVTGRALLRTDSAGSRTDSARLRGGDGAAQSAPVDLLDCPPRQLARQVRGRVVGLVPQSPATSLTPVRTGRRLLEETLRAHGHTRADAPAAADRLAVDVGLDPADLDRYPHELSGGMAQRLATALALAPDPPLLLADEPTTGLDRPLVDHTLDLLRRRCDAGAAVLLITHDLAAAQRVADTVAVMYASRIVEHAPTEALFEAPGHPYSAALLDALPQRAFRPVPGHPPMLTDLPAGCAFAARCDRATPTCRVQPAFTGTRSGQVACHHPLERAELCAEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAW6</accession>
    <name>F4FAW6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24155"/>
    <dbReference type="EnsemblBacteria" id="AEB45929">
        <property type="protein sequence ID" value="AEB45929"/>
        <property type="gene ID" value="VAB18032_24155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24155"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508819_0_0_11"/>
    <dbReference type="OMA" id="CGTINVT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313731" evidence="1">
        <location>
            <begin position="18"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="516" mass="54013" checksum="B7C84FA2339C51E2" modified="2011-06-28" version="1">MLAAAGTAIAAPSPAQAATVDPNATYVFVNRHSGKAMDVWNWSTADQAPINQFTRNDAAVQQWRFVDVGSGYYQIRSVHSGKVLELPNANDGVQLVQNTAAGGNTRQHFRLADSDGGHVRFVNRHSNKALDLWGWSTADGAMISQYQDVNGANQQWRMITVGGGSGSGCGSGTFQAEAVLNGGTWTARNGGTTVYTGGDMREAVQAAINSLSAGRTSKQRVVVRGSGSISAGSRISLPSYTTIDVCGTINVTGSGSGDQAPIYSRGTTQVEVQNLNVTGAPLYGIFMRNVSNVILGQIDMRLSSGLGIRIDNRGDTSQWSRNIRIDNVYVSGARAHAVETYGVDGLTIGTVTARNVGESGLLLNETINATVTTVDAENAGTGTGYAAFRIANRAGRINSGYPINIRVGTVRARGGGRGIFCVSESGGLAVNRVDVANTGNNAILIENCYGVDIAAGGGTISGGGEVRLAARSEFPGNRDITLRNFTLVNSRILESPCTANLVISNVALNNASINRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB13</accession>
    <name>F4FB13_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24390"/>
    <dbReference type="EnsemblBacteria" id="AEB45976">
        <property type="protein sequence ID" value="AEB45976"/>
        <property type="gene ID" value="VAB18032_24390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24390"/>
    <dbReference type="eggNOG" id="COG4260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037108_0_0_11"/>
    <dbReference type="OMA" id="AEVYFVN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band_7_1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="GYF_2" evidence="2">
        <location>
            <begin position="320"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="383" mass="40894" checksum="F1D59A3EE44CFF60" modified="2011-06-28" version="1">MDRLRGEFVDIIEWLDDSRDTIVWRFPRFQNEIKMGAKLVVRESQTAVFVNEGQVADVYLPGTHTLETRNMPILSTLKGWKYGFNSPFKAEVYFVNTRQFTEMKWGTQNPVILRDPEFGVVRVRAFGAYAARVVDAQRLLKELVGTDPQFRTEEVQEYLRQLIVGRLGGALARAGVPLLDLAAHQDAIGRQLAGALTEELAEVGIAIPKFVIENVSVPPEVERALDKRTEMGAVGDLDRFTRYQAATALEAAANNPGGEAGAGVGMGMGMALGQQMARAMSGESSAPPAAAPQAAAPYAAPTAAAPGGAEPPPLPGQAQWFVGVGGERQGPFDIGALAARAGAGGFGPDTLVWRAGMAQWQPAGQVPELASVLASVPPPLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBD1</accession>
    <name>F4FBD1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05505"/>
    <dbReference type="EnsemblBacteria" id="AEB42227">
        <property type="protein sequence ID" value="AEB42227"/>
        <property type="gene ID" value="VAB18032_05505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05505"/>
    <dbReference type="eggNOG" id="ENOG5033UCK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071051_0_0_11"/>
    <dbReference type="OMA" id="RGWGRVY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="250" mass="26670" checksum="1AB345D6AB961B00" modified="2011-06-28" version="1">MGPYRDPDSAERRTAARAARALVAGGDETEDADRLFAELGFQARHGIDSATGRECSSYLATGSDRRTWGAVLVDRSATARTVIEVPHPGFDINTEKIGLALHRRLPGSVLLVAGAHRQAAAGAADVAHNNRSLFHSLAVAFAEAGLDEIQLHGFADRNLPSSDVVVSTGAAPTNRLARRIADSLSELGLRTCRSWVRRCGQLEGRTNQQGRAAAEAGTVFVHLELNWSIRSDSTIGDRVVAALAERLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBE5</accession>
    <name>F4FBE5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase A24A prepilin type IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_05575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05575"/>
    <dbReference type="EnsemblBacteria" id="AEB42241">
        <property type="protein sequence ID" value="AEB42241"/>
        <property type="gene ID" value="VAB18032_05575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05575"/>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057101_2_0_11"/>
    <dbReference type="OMA" id="GCDACGT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="5">
        <location>
            <begin position="118"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="26939" checksum="874A99CBF1F5C5C3" modified="2011-06-28" version="1">MSQPATTESARPDDIPPTPARRRPMAVLALTPLLRYAVARHAVPTGTDRRSGCDACGTPIGLDRPWPALGPTARCGTCRARIGAPPFTVELVTVVALAMLLLAGPPAGELVAAAWWLIFAVPLVFVDLAVHRLPDRLTLPAAAGTWLLLGLTALVDAGPAPWLRATAAALGLAGFFATTTLLFGARGFGIGDAKLALGAGALLGWYGWATPVLGLLLAVMLSGLVALGLLVTRRARWSSHLPFGPYLVLGTLGALLLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBI5</accession>
    <name>F4FBI5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsB</name>
        <name evidence="7" type="ordered locus">VAB18032_11665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732116.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11665"/>
    <dbReference type="EnsemblBacteria" id="AEB43447">
        <property type="protein sequence ID" value="AEB43447"/>
        <property type="gene ID" value="VAB18032_11665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11665"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_2_2_11"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="32074" checksum="E8052A48D2421931" modified="2011-06-28" version="1">MAVVTMRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLRQTLDYIEKAYEFVRNTVAEGGSILFVGTKKQAQEAIAEQATRVGQPYVNHRWLGGMLTNFQTVYKRLQRMKELEALGDLSGTAAGYTKKETLQLSREKIKLTKTLGGLRDMQKLPAAVWIVDTKKEHIAVDEARKLGIPVIAVLDTNCDPDEVDFPIPGNDDAIRSAELLTRVVAAAVADGLIARSGRRRGGDEKPEAGVATDEPLAEWERELLEEPKKADEEPAAEQAPAEQAPAEQPAAVSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBR7</accession>
    <name>F4FBR7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733372.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18075"/>
    <dbReference type="EnsemblBacteria" id="AEB44717">
        <property type="protein sequence ID" value="AEB44717"/>
        <property type="gene ID" value="VAB18032_18075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18075"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_11"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031021">
        <property type="entry name" value="Endura_MppQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04461">
        <property type="entry name" value="endura_MppQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="50"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="383" mass="40153" checksum="11663D3E327BB5F9" modified="2011-06-28" version="1">MTGGGYWRAGVVQSVPPTGTTDLGPGYLDPALLPVRLLAQAYAQALDEFGPAALTYGENRGPAPLREAIAARVGTGPEHVLVTAGTSQGLHLVAGLFGRPDDVVLAEPLSYDYGLRILTDRRLRIEVIESDMDGPVPGALTAAVRRVRRAGRRVGFAYLIPTHRNPTGVTVPDERRRALVTEAADVGVPIVEDDAYAGLRYDGPPEPPSLHALAGRRGVVRLGTFAKTLAPGLRLGWLEADPRLVDRCAATGWADSGGGFNHLAALAVAGLLSGGDYDRHVAWLREELRARRDALVDALGVVPPYGGFFVWLPAPAGDGQALRERAAAARVSVADGRRFGAAGAGAVRVAFSFQPPPVLSAAGHRLAAARAASARLDATTTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBS6</accession>
    <name>F4FBS6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_18120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733381.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18120"/>
    <dbReference type="EnsemblBacteria" id="AEB44726">
        <property type="protein sequence ID" value="AEB44726"/>
        <property type="gene ID" value="VAB18032_18120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18120"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="DVWVPPD"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="25044" checksum="FF0929058E561C15" modified="2011-06-28" version="1">MIRVMLADDQTLVRAGLRALLQSEPDIEFVGEAADGEQTLRVAAQVRPDVLLMDIRMPRMDGIEATRRIAARPELSDIRIVILTTFEHDQYIFRSLRAGASGFLVKDIEPAALLQAVRVVAAGEALLAPSVTRRLIAEYAARSHEPPASPGLDQLTAREREVLMLIARGLTNQELAERMSCSVATAKTHVSRVMMKLGARDRVQVVVLAYEWGLVQPGWRDAGPVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBV0</accession>
    <name>F4FBV0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoin dehydrogenase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733405.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18240"/>
    <dbReference type="EnsemblBacteria" id="AEB44750">
        <property type="protein sequence ID" value="AEB44750"/>
        <property type="gene ID" value="VAB18032_18240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18240"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_0_11"/>
    <dbReference type="OMA" id="FEAYDMA"/>
    <dbReference type="OrthoDB" id="1248201at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="32696" checksum="89BED9FAB9943D9E" modified="2011-06-28" version="1">MGLPDDYRAMARIRRFEERLTALKDAGEIPGSIHLCNGQEAIPVGAARTLRDGDYVTATYRGHGWALARGVDMTGLFAEMMGRDSAVNGGRAASPYLSDPGRWFVGENSIVGAGVPIATGAALTAQRTGSGAVSVVSIGDGAMNQGNVHEALNMAAVLDLPLVLVVENNVYSEMSRIEDMVRVRQLAERAAGYGIPGRVVDGNDPDAVADAVGEAVTRAREGSGPSIVEAMTERLVGHYSGDVQHYRPAGEVAAAREREPLARIRAAADADLAARLDVIDAEVAAEVEAAIAAARAVPYPDPATVKEYVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBZ6</accession>
    <name>F4FBZ6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol diphosphatase</fullName>
            <ecNumber evidence="6">3.6.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CDP-diacylglycerol phosphatidylhydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">CDP-diglyceride hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">VAB18032_24480</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="3.6.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Cdh family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.26" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734646.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24480"/>
    <dbReference type="EnsemblBacteria" id="AEB45994">
        <property type="protein sequence ID" value="AEB45994"/>
        <property type="gene ID" value="VAB18032_24480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24480"/>
    <dbReference type="eggNOG" id="COG2134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078490_0_0_11"/>
    <dbReference type="OMA" id="NDPARWR"/>
    <dbReference type="OrthoDB" id="1854066at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="UniPathway" id="UPA00609">
        <property type="reaction ID" value="UER00664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008715">
        <property type="term" value="F:CDP-diacylglycerol diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046342">
        <property type="term" value="P:CDP-diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003763">
        <property type="entry name" value="CDP-diacylglyc_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02611">
        <property type="entry name" value="CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB45994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="31466" checksum="AD54006B3EBB17EB" modified="2011-06-28" version="1">MGDNRATGNIHRRQFVRLSGAVGATGLWGLAGGGAALADGGPAPGPPAPDPGGPGGSACPTPSQLCGYPSDTGGRYDLWDRVQVCEGTKPGPPFPQCLATTPTYVILNGGSGSNHDFLLVPSCRISGIECPFIATSSAPNYWLDAWNNAQPGQPGHVVYPHIGLGVNSADPTIRQQDQLHIHLAGIHSGIQTQLNNHDSAITNDPARWRTQIVPVWGLTSTGAPAPRSYRVLHVANLNTNLFTLLRDSVVRPTGASMAAQILAVTPRLVGNGGFYVLNSEPGLPVPPGQPGGTGTVDFLLAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBZ8</accession>
    <name>F4FBZ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_24490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24490"/>
    <dbReference type="EnsemblBacteria" id="AEB45996">
        <property type="protein sequence ID" value="AEB45996"/>
        <property type="gene ID" value="VAB18032_24490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24490"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_0_11"/>
    <dbReference type="OMA" id="CMDFELG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="208"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="318" mass="34181" checksum="4D84C4FEDC2DEAB6" modified="2011-06-28" version="1">MLSDVIAVMRTGQPRSARVAWHAPWTQQFASMPGSAGFQVILQGRCWLVQAGSEPVALSTGDVVFRPHGRGHVLVDSPATPATGPACDPDAQPTLHRHDSDTDRPATAPATIILCGGYQFDTARTHPLLPDLPELIHLPAHLGRHPQLHATVQLLGDELAHPRLGTDAIVPALLDTLLLHILRAWLDGQPVRASDTGWAAALNDGPIAAALNAMHRDPARPWTVAALAAEAGLSRTPFARRFTALLGQPPLTYLTWWRMTTAARLLQESDAALNVIATKVGYTSEFAFGNAFKRHHAVAPGRYRRSGGGLVPARTAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC42</accession>
    <name>F4FC42_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine--scyllo-inositol transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734692.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24710"/>
    <dbReference type="EnsemblBacteria" id="AEB46040">
        <property type="protein sequence ID" value="AEB46040"/>
        <property type="gene ID" value="VAB18032_24710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24710"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_2_4_11"/>
    <dbReference type="OMA" id="HTDFGNS"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="380" mass="41309" checksum="EFE1CBDF3EC368E9" modified="2011-06-28" version="1">MINIFQPSLGEAELAAVAEVFATNWIGKGARVDGFETAFAQHIGVPRPLVTSFNSCTAATFTAVELAGIGPGDEVIIPTVCFVGVANAVAAAGARPVFCDVATRTLNPSVADLDAVRTERTRAVIVLHYGGHPGDIVAIADWCRDNGILLIEDAAIAIASRVDGRACGTFGDMAAWSFDHGKIVVTVDGGMLYVRDPELAERAPTLAYLGLEQSSGYDSALRQRTRWWDFEVSSFSGRSVTNDVLAAIGAVQLRRLPEFIARRREIAAHYDEALANVGGVACPPPLPAGHETSYYMYWIQFDGDIRDEIARDLYEEGIYTSFRYPPLHRVKAYGSDARLPCAEEAAERTLLLPIHQALTDAEVERVAETVRRRVQVRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCE6</accession>
    <name>F4FCE6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_05735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730946.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05735"/>
    <dbReference type="EnsemblBacteria" id="AEB42273">
        <property type="protein sequence ID" value="AEB42273"/>
        <property type="gene ID" value="VAB18032_05735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05735"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="VVVTHML"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="73"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="29136" checksum="85CC375C24D45A8A" modified="2011-06-28" version="1">MNADEWLRVFAAELHQRRVADDAARHVVAEAATHLREGGGDPWLVFGPPQAYAATIVESIGTAPRPRPGPVRLDARGITKRYGRHTVLRDVALTVRAGQIAAVVGANGCGKSTFLRICAGLVSPDAGAVTVSGRLGFCPQQGGTADFLLPDEHFVLVGAGQGVARGPARRAGRAAARQLGWEAQDDVLARHLSGGTRQKLNLTMSTLAAPDVLLLDEPYQGFDQGSYVNLWDQLIRLRDEGRAIVVVTHLLNQLDRVDVVLDLTTGNPGDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCW3</accession>
    <name>F4FCW3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18465"/>
    <dbReference type="EnsemblBacteria" id="AEB44795">
        <property type="protein sequence ID" value="AEB44795"/>
        <property type="gene ID" value="VAB18032_18465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18465"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_11"/>
    <dbReference type="OMA" id="IFRRMKM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="433" mass="48954" checksum="81F22129C6C9DB0B" modified="2011-06-28" version="1">MLRTLWQLAQDRLGMMRTAASYGDVVRLGPSFKRLYFFNHPDHAKYVLADNSQNYHKGVGLAQARRALGDGLLTSEGELWRKQRRVIQPAFQAKRIAAQAGVVVEEAAGLVQRLRAHRDGAPVDIVKEMTGLTLGVLGRTLLDSDLSEHRSVGHSFEVMQDQAMFEMVTMGSVPTWLPLPHQLRFRRARRDLQRVVDALVAQRRARGEEGDDALSRLIVSTRQEADPRVGRLRMRDELVTLLLAGHETTASTLGWTFHLLDRHPEVLERVRAEAVEVLGDRQPVYEDLARLRFTAQVINEAMRLYPPVWMLSRIAQQPDVIGGYHVPGGSDVLICPYTLHRHPEFWDDPDRFDPDRFDPARPNDRPRYAYVPFGAGPRFCVGNHLGLMEATFVTAMVVRELRLTGDPAYQVVPEPMLSLRIKGGLPMRVTVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCZ7</accession>
    <name>F4FCZ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733484.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18635"/>
    <dbReference type="EnsemblBacteria" id="AEB44829">
        <property type="protein sequence ID" value="AEB44829"/>
        <property type="gene ID" value="VAB18032_18635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18635"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="LQRYYMR"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="32923" checksum="F52D313621B70767" modified="2011-06-28" version="1">MTVASTTESAVTDGPAPPTPSRHEGRKKTEGMTIAGIALRTPYWVFTGAVALIFLAPLVWTAVASVSPQPGTNQVDGWGFGNYRTLAAYQAGIWRYLANSAFVSLLTVTLTLLISFLGGYAFARFRFPGKNLLFLITLAILMVPYATLLIPLYVLLNQVGLQNSLVGVALVLTMFQLPFSTFLMRISFEAVPRELDEAAMVDGCSSFGALWRVLLPAVKPGLITVGLFGFLAAWNDFMAPLILINDSERMTLPLAVSNLRGQVQGVVDYGATEAGVVVLALPCIVLFLLLQRHYVRGFMSGALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD04</accession>
    <name>F4FD04_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_18670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733491.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18670"/>
    <dbReference type="EnsemblBacteria" id="AEB44836">
        <property type="protein sequence ID" value="AEB44836"/>
        <property type="gene ID" value="VAB18032_18670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18670"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="OMA" id="ICGPQNI"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="341" mass="36101" checksum="ADEC138D5A26C30E" modified="2011-06-28" version="1">MTESEVPAKRPPTLTDVAKLAGVSVATASKAINGRGEVRATTRVRVLEAAELLSFAPNALARGLLSGRTGTVGLLTSDLEGRFSIPILMGAEDAFGAGQVSVFLCDARGDAIREKHHVQALLSRRVDGLIVVGSRTDPRPPLAGNIAVPVVYVYAPSADPKDISITADNVGGGRLAIEHLISCGRRNIAHITGEAGFQAARDRVEGATAALTAAGLRMVGDRPYFGSWEESWGRAATHMIVEQHPEVDAIFCGSDQIGRGVLDALRDLGREVPGTISVIGFDNWEAISADSRPRLTSVDMNLKHLGAVAGKRLFEAIDGTVPRSEELPCRVVMRESTMPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD42</accession>
    <name>F4FD42_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734724.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24870"/>
    <dbReference type="EnsemblBacteria" id="AEB46072">
        <property type="protein sequence ID" value="AEB46072"/>
        <property type="gene ID" value="VAB18032_24870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24870"/>
    <dbReference type="eggNOG" id="ENOG502ZBF7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080184_0_0_11"/>
    <dbReference type="OMA" id="KIIENFW"/>
    <dbReference type="OrthoDB" id="1861154at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="136"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="31772" checksum="CB3BCF09DFA4020D" modified="2011-06-28" version="1">MTSSLSLRPITGWSGNKDYFTFREYDKFDPEAVIDVLDGKVAGVMFRGMVAPEVAANISQRFWDSPHRKVRGVEAPGYYIGAYTWNKPTGQYLDEAEEANPILRDLLDVPNDPMKEFYAGLGSSLAKRGAVVRPAEHEGRSAAIALFRSWHGRGAFALEPHDDDSQCSDPQMADFERNRVFGNPIAALNICLENEGGGGRLVYWNIQPDLESKRRLGVEYTGSPYPHECLVDVESKWIDVHAGDVYVFNGAHVHAVEPNTTERQTRTTLAAMMAYADPQNVVTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDB8</accession>
    <name>F4FDB8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rplK</name>
        <name evidence="11" type="ordered locus">VAB18032_01225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735966.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01225"/>
    <dbReference type="EnsemblBacteria" id="AEB47329">
        <property type="protein sequence ID" value="AEB47329"/>
        <property type="gene ID" value="VAB18032_01225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01225"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_1_11"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB47329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="143" mass="15281" checksum="414AA01B27FFAD7F" modified="2011-06-28" version="1">MPPKKKLVKTFTLQLPAGQATPAPPVGPALGQHGVNIMEFCKSYNAQTESQRGDIVPAEISVYEDRSFTFVLKTPPAARLLIKAAGVQKGSGVPHKEKVGSVSRAQVREIAEKKMADLNANDLDQAEKIIAGTARSMGLNVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDD6</accession>
    <name>F4FDD6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoN</name>
        <name evidence="8" type="ordered locus">VAB18032_01315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01315"/>
    <dbReference type="EnsemblBacteria" id="AEB47347">
        <property type="protein sequence ID" value="AEB47347"/>
        <property type="gene ID" value="VAB18032_01315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01315"/>
    <dbReference type="eggNOG" id="COG1007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="494" mass="49256" checksum="05A2FCE583B84FCE" modified="2011-06-28" version="1">MQSVDSVALLPAYLAAGTAVLALLVDLVLARRTATIVAAATGALATLVAAVAVGAGAERRTFCVGADCSYVFGGRAALVAGLVALLALGVLALSGPLLRDGVTPVGEFCFLLACSMTGGVVLGAAGDLITLIVAVEALTLPLYILVGLRRGSLASAEAAVTFFVVSVVATTLTLLGAALLYAVTGSLHLERLGAILADRSDLLDLPLTTVAVTLVLAGLAFKVAAVPFHAWAPATYDGAPLPVAAYLSTASKLGGVVALLAVVQHALPLSVAGPVLALVAALTMTVGNLVALRQRRTVRLLAWSSVAQAGYILAPLGALALADVDARSTAYAAALAYAVFFVLLELAAFAGVVALRPAGADGGRLDDLRGAARRHPWVGAGLAFALIGLAGLPPGLAGLFAKVTVVRSLLGGDAAWLALLVALNAVIGLAYYLRFAALLYTPTDSAPAGSAPAGDAPVGAIRPARVVVAALAVATAIAVIVGFAPQLVLDLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDG1</accession>
    <name>F4FDG1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736008.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01440"/>
    <dbReference type="EnsemblBacteria" id="AEB47372">
        <property type="protein sequence ID" value="AEB47372"/>
        <property type="gene ID" value="VAB18032_01440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01440"/>
    <dbReference type="eggNOG" id="ENOG5032YJA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168842_1_0_11"/>
    <dbReference type="OMA" id="KIGVQHA"/>
    <dbReference type="OrthoDB" id="1975208at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="75" mass="8124" checksum="B19F83D20CA36EF1" modified="2011-06-28" version="1">MEVKIGVQYAPRELVLESAQSPAEIERIVTDAVARGEGTLSLTDEKGRRIIVPVSKVAYVEIAEASPRAVGFTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDL3</accession>
    <name>F4FDL3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acsA</name>
        <name evidence="9" type="ordered locus">VAB18032_06260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731049.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06260"/>
    <dbReference type="EnsemblBacteria" id="AEB42376">
        <property type="protein sequence ID" value="AEB42376"/>
        <property type="gene ID" value="VAB18032_06260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06260"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_11"/>
    <dbReference type="OMA" id="AIKASWP"/>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="89"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="540"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="386"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="410"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="664" mass="72132" checksum="704E2C62977003EC" modified="2011-06-28" version="1">MSEALANLLNETRQFPPPAELAADANVTAEAYAEAEADRLAFWERQAGRLAWARQWDQVLDWSNPPFAKWFVGGQLNVAYNCLDRHVEAGRGDKVAIHWEGEPGDTRTITYADLHRMTCQAANALTDLGVVAGDRVAIYMPMVPEAAVAMLACARIGATHSVVFGGFSAESLTNRIQDASAKVVITADGGYRRGKPSALKPTVDEAVANCPSVEHVLVVRRTGESVDWSQRDHWWHETVEQASTEHTAEAFDAEHPLFILYTSGTTARPKGILHTTGGYLTQTSYTSHAVFDLKPETDVYWCTADIGWVTGHSYIVYGPLSNGATQVMYEGTPDTPHKGRFWEIVDRYGVTILYTAPTLIRTMMKWGDDIPAEYSLSTLRLLGSVGEPINPEAWMWYRQHVGRGELPIVDTWWQTETGSIMISPLPGVTAAKPGSAMTPLPGISADVVDDQGQSVPNGGGGYLVLREPWPSMLRTIWGDDNRFIETYWSRFGAGASGTGGDEWIYFAGDGAKKDDDGHVWLLGRVDDVMLVSGHNISTTEVESALVSHPSVAEAAVVGATDPTAGQAIVAFAIPRGSTDISGEAGEQLIADLRNHVAKTLGPIAKPRQIMLVPELPKTRSGKIMRRLLRDVAENRSLGDVTTLQDSSVMELIASGMGGGKSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDM7</accession>
    <name>F4FDM7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06330"/>
    <dbReference type="EnsemblBacteria" id="AEB42390">
        <property type="protein sequence ID" value="AEB42390"/>
        <property type="gene ID" value="VAB18032_06330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06330"/>
    <dbReference type="eggNOG" id="COG1205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_11"/>
    <dbReference type="OMA" id="CIQSPKC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="85"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="321"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="815" mass="86491" checksum="D0AC7D6AC7447FDE" modified="2011-06-28" version="1">MTSAASVSAGRDREPGPAPIPAAAPGDLLRQLRRRHATDPVTHVERVPSRAGTPAPWPGWAPEELRTAYARRGVSAPWRHQAEAAELAHDRRHVVVATGTASGKSLAYQLPALATLLADARATVLYLAPTKALAADQLRAVAELEIEGVRPACYDGDTPRAEREWIRRHSRFVLTNPDMLHHGILPGHAQWSGFLRRLRYVVIDECHVYRGVFGSHVSHVLRRLRRQCARYGNTAGPTFVLASATSGDPAATAGRLVGLPVTAVTEDTSPRAGVTFALWEPPLLPAEASASSPTTAAPAPRRAPDAPRPTAPPGPDAEPGDLTQVRRSALRETADLLADSVAAGVRTLAFVRSRRGAEVVATSARRSLDEAVPGLGDRVAAYRGGYLREERRALERALLHGDLLGLASTNALELGVDLVGLDAVLICGYPGTRASLWQQAGRAGRSGQEALAVLVARDDPLDTYLVHHPEALFGTPVEATVLDPANPYVLGPQLACAAAEAPLTAADLELFGDSAKETVEALVEAGALRQRPTGWYWRHRERPEVDLRGEGGAPVCVVEAATGRLLGTVDGGSSHFLLHPGAVYLHQGVSYVVDSLDLEDGCALVHPEEPDWSTHARDVTSLSVVSVRSYVDAGPVGLFLGEVDVTSQVVSYQRRRIATGEVIDTRPLDLPTRELRTVAVWFTLSPESLAEAGVDPADVPGALHAAEHAAIGLLPLLATCDRWDIGGLSTAVHPDTEAPTVFVYDGHPGGAGFAERAYGTAAAWLKATRDAIDECGCEAGCPSCVQSPKCGNGNNPLSKPGAVRVLDVVLNNLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDP3</accession>
    <name>F4FDP3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06410"/>
    <dbReference type="EnsemblBacteria" id="AEB42406">
        <property type="protein sequence ID" value="AEB42406"/>
        <property type="gene ID" value="VAB18032_06410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06410"/>
    <dbReference type="eggNOG" id="ENOG50302MI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1358049_0_0_11"/>
    <dbReference type="OMA" id="RRMQVLP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="24334" checksum="8B3CE5200E3E8072" modified="2011-06-28" version="1">MDALDRLAEPGLDLLRRVDTLLAAGAPEGHRVWPLLRRMQVLPGEALRHFLDLRSGPLAAAGQAVRRHVHGYDRACAALTDPQLWSGPAAAAYGETRAVLLRHLDEGPESLVGRLEATAGYAEALADWVEGSRLAVARALAEVIGSAEAVTVVTATSVTRVVSHSGPSSPGAVAAAEIAARLLAVLCVAYDGAETLVRQWGPSMAESVLRPPAAQARPGFHDGPRTIRASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDQ2</accession>
    <name>F4FDQ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_06455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731088.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06455"/>
    <dbReference type="EnsemblBacteria" id="AEB42415">
        <property type="protein sequence ID" value="AEB42415"/>
        <property type="gene ID" value="VAB18032_06455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06455"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1554643_0_0_11"/>
    <dbReference type="OMA" id="WDPMGEL"/>
    <dbReference type="OrthoDB" id="1704944at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="172" mass="18589" checksum="502E435E4FA5C07B" modified="2011-06-28" version="1">MTGPGRGWRAGQQGWDPLGELQSLRTELRRLVGGRPGPPEVELGETADGWEVIVRLPGVAPEEVAVELDDRELCVRARTEAEVNADHGISGGFETRGFDYRVQLPARVDPDAIDAVMDHGLLRVRLPRPNRPSPRTIPVGRGGPYSGASSGIDPAADRELHHPDVALGEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDW4</accession>
    <name>F4FDW4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12655"/>
    <dbReference type="EnsemblBacteria" id="AEB43645">
        <property type="protein sequence ID" value="AEB43645"/>
        <property type="gene ID" value="VAB18032_12655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12655"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016537_0_0_11"/>
    <dbReference type="OMA" id="FEWMLAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="603" mass="64067" checksum="7C57FBB919BE9843" modified="2011-06-28" version="1">MGRTGVDRPDGLMPVGTAERPVQATTRRRLRVPRTPDAAVVAGYLAVAAWLTSRQWGRPDRLFHQAGDQILFEWMLARAARAVTGVENPLWSDALNVPGGVNLMANTSVLGLGVPLTPVTLLFGSQTAFVVAVVGCLAGTATAWYVLLRRRLVRSRVAAAIGGLICGFAPGMVAQAGAHLHMAAQFLVPVILALVFRAEPAGRVWRYGLLLGLAVTYQVFLGEELLLFVALAAGVFALGYALADRAAARRLAPGLAARIGIGAVVAAVLLAYPLWFQFFGPGHYRGMPFYAHAYQLDVASFPALARQTVLGDGRSSALLAPNPTEENSFFGPGLLVLAVLATAWLWRRPLVRALAGCGVVFALLSLGTPVRLDAEVTELAGPYRLISGLPLLDHVVPARFALVCVPVLGMLVALAADRVARQWAATRSAVRLLWAGALAAALLPLTPTPIRTVSVWPVPAFVADGTWRAYVPAGRTLVAVPPVTNHGRSPAMLWSARTGLAFTAPGGFFIGPKAADDPTARWGAPDRPTSALLRRVADTGELPSITDADRRQAVADLRHWRAAVVVQGELRHGDAVRRTVEALLGPSRPIDGALVWDVRPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE52</accession>
    <name>F4FE52_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_19095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733576.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19095"/>
    <dbReference type="EnsemblBacteria" id="AEB44921">
        <property type="protein sequence ID" value="AEB44921"/>
        <property type="gene ID" value="VAB18032_19095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19095"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="HDLGVMS"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="34297" checksum="8B645FD25E7B5D80" modified="2011-06-28" version="1">MAPLLDVDSLAVTLPGPRGPLPILHDVSLTVDEGELVGIAGESGCGKSLTAQTLLGLLPPGATVRGSARFAGTDLLGLDQRGWQRVRGAGIAMVFQDPTAALHPMLTIGRQLTEHMRVHLRMDRRAANRRAVELLDQVRIPDPERALRSYPHQFSGGMRQRAAIAIALAARPRLLIADEPTTALDVTVQAGILALLDRLRAETGLAVAFITHDLGVLSALTTRGYVFYAGRVVETGPTGELLTAPTHPYTAALLGARPHGTQAVGTLRPIPGSPPAPGQAPPGCPFQPRCGYAEPACGTSPPPLTPAGEHRSVACVVRPHLEVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE55</accession>
    <name>F4FE55_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733579.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19110"/>
    <dbReference type="EnsemblBacteria" id="AEB44924">
        <property type="protein sequence ID" value="AEB44924"/>
        <property type="gene ID" value="VAB18032_19110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19110"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018914_3_0_11"/>
    <dbReference type="OMA" id="GHHLQHA"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="550" mass="59160" checksum="23B6E69C6F00DA1F" modified="2011-06-28" version="1">MTVIRVADDYLAALADLDPQAAEAAGRTPDSQLADLSPEAFDARAALARQTASAAASATADGPAQRALAGALAERLTSEVALYDAGFTTRLLAPLATPVHLARQVFDNLPRQTADDWAAVAEHLHRLPDTLDQYAATLRRSAQRGHLVARRQVLVVAAQCQSWTADDFYGRLVAGSPGGPLADRLTEGARRATAATDAFATFLRTELAPGASEVDGVGRELYEVTSRAFLGATVDLDELYAYGWAELARTDAELHAAAADCGHPDPASARVALDADPAGRVSVGPALEQWLRKRTALLTDQLDGVHFDIPAVTRHVECRISPAASGVMYYTPPDANLTRPGGIWWSVPPGESSVPVWRHVGTLCHEGLPGHHLQHAVTLTTAELHPWQRHLCQVHGYAEGWAHYAERLADELGLFAGPGERLGMLDGQMWRAARVVIDLGLHLDLPIPAGTGFTDADRWTPAVAVDLLTRVAGLDAATARFEVDRYLGWPAQALAFKVGARLWQQTRRDAERRAGAAFDRKRFHHTALVLGPMGLDPLRARLAEALPPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEF5</accession>
    <name>F4FEF5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734873.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25615"/>
    <dbReference type="EnsemblBacteria" id="AEB46221">
        <property type="protein sequence ID" value="AEB46221"/>
        <property type="gene ID" value="VAB18032_25615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25615"/>
    <dbReference type="eggNOG" id="ENOG5032EQ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086002_1_0_11"/>
    <dbReference type="OMA" id="HVEVVWH"/>
    <dbReference type="OrthoDB" id="1407012at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="27388" checksum="AA8DC41513D22E4C" modified="2011-06-28" version="1">MSTPAAGAAILAPRRSSRFVAWVRAWRAGLVPFDEVADEVAGDEEHHVADAPGTWTDVPLREALPTLAKLSPDEIRLVLPAPGDPRGLPGPGDFAGAALLAGEAVVAGAMGLIPEVRVHTSGSGDTFETVLWRVYPLPANAPAASLTLPGAAEAEAELAAALADTTAALTRLDVAQWRPELAGALEALRRPDGTTDLPPGFDPRARRLFARAAVLDRVLALAGHAAPGGAVNNYEAQQRDAALRPLTTACRQALVAACNAPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEI4</accession>
    <name>F4FEI4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736061.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01710"/>
    <dbReference type="EnsemblBacteria" id="AEB47426">
        <property type="protein sequence ID" value="AEB47426"/>
        <property type="gene ID" value="VAB18032_01710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01710"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103702_2_0_11"/>
    <dbReference type="OMA" id="EHYARLM"/>
    <dbReference type="OrthoDB" id="1859598at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="123" mass="14066" checksum="E73A54439A6B43CC" modified="2011-06-28" version="1">MDLLTEYRRATLFFESGDPTGAARLLEPIIEAEPDNAAVRQLLARAYFQSAQLGRAEEHLRELVDRNPSDHYAHHVLGRTLERLNRHTDALRHLRIAAAMHNANNDYTTALRRVETRLGARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEM1</accession>
    <name>F4FEM1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736097.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01895"/>
    <dbReference type="EnsemblBacteria" id="AEB47463">
        <property type="protein sequence ID" value="AEB47463"/>
        <property type="gene ID" value="VAB18032_01895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01895"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_1_0_11"/>
    <dbReference type="OMA" id="WKHGIET"/>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="122"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="23332" checksum="2651414823F534F2" modified="2011-06-28" version="1">MRDEFRAELQAVSQLLVEMAEGVRAALRQATRALLTADRQAAETVIEQDARIDALYRQVEERVCDVLARQAPVASDLRAMITALHVAADLERMGDLADHVAKTALRRHPSPAVPAELRPVFTDMAGIADRMAEKIAAVLAHPDADLAAELDRDDDAMDELHKGLFGVLLGADWPYGVETAIDATLLGRFYERFADHAVNSAEHVVYLITGEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEQ0</accession>
    <name>F4FEQ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06600"/>
    <dbReference type="EnsemblBacteria" id="AEB42444">
        <property type="protein sequence ID" value="AEB42444"/>
        <property type="gene ID" value="VAB18032_06600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06600"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_1_11"/>
    <dbReference type="OMA" id="DRRQKMV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="15509" checksum="59DE4B42B4E07703" modified="2011-06-28" version="1">MPPAQLAHQLRDAITRLNRRVRQARPVGDLTVTQLSALTSIRLGGALTPRELADVERVQPPTMTKIVAKLEERGLVQRTPHPTDGRQVILAVTAGGQAVLDQFERVRDEWLARRLTELSDADRETLQHAAEILQQISRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF46</accession>
    <name>F4FF46_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733606.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19245"/>
    <dbReference type="EnsemblBacteria" id="AEB44951">
        <property type="protein sequence ID" value="AEB44951"/>
        <property type="gene ID" value="VAB18032_19245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19245"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051827_1_0_11"/>
    <dbReference type="OMA" id="WIEIPRE"/>
    <dbReference type="OrthoDB" id="1105091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307864" evidence="2">
        <location>
            <begin position="31"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="35345" checksum="9B38AC353DDA9E43" modified="2011-06-28" version="1">MTRCPFPHLVAATAVLTVLATVLTVGPAAALTAAPAPTPTPSATGFTWAVQPSGPSGPTGRSYFVHDAEPGQRIDDRVAITNLSERAMTFAVYGADAFTTTDGGFALQPASRPATDVGAWTTFAERTYRVPAGEQVIVPFQLTVPANATPGDHAGGVVASVAQVQSAGDGGQVNLDRRVAARMYLRVAGPVRPGLQVEAMRIGYDNPLNPFGTGPVVVSYRLRNTGNTRLTGTAQVRLTAPFGIRLARTEPVDVPELLPGAAITITEQINGVVPAGRLTAAVVVDPATPDQILPTVRRTAGTWAVPWVWAAVLLTGLGWLLVIRLRSARRRPPTVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF85</accession>
    <name>F4FF85_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733645.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19440"/>
    <dbReference type="MEROPS" id="S12.A11"/>
    <dbReference type="EnsemblBacteria" id="AEB44990">
        <property type="protein sequence ID" value="AEB44990"/>
        <property type="gene ID" value="VAB18032_19440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19440"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035614_3_0_11"/>
    <dbReference type="OMA" id="EFPGTNA"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="382" mass="40981" checksum="52E50D97B41A3B02" modified="2011-06-28" version="1">MTDTQIHGDVADGFGRVADVFRDNFTHRQEVGAAVAVYRRGRKVVDLHGGSADPRSGRPWTARTPAVVFSCTKGIMTICAYLLVQQGRLDLDAPVTRYWPEFGQNGKAEIPVRWLLTHQSGLSALDKPFTREEVLAWDPVIQAIEAQAPLWKPGTAHSYHPITFGWLIGEVIRRITGELPGVWFARALAEPLGLRTWIGLPAAERDAVAWMLGPIGDPGPEIDPVSERAITMGGAFPFPADENNEVSFNDPAIQAAQVPGAGAVSTAESLARLYAACVSEVDGPRLLTAASVDDAIAVRAAGQQVYGHPDAGHQWGTGFLVHSLPRPMLGPRSFGHDGAGGHLAFGDDAHQVGFAYVVNQMGGFDDERANLLSAAVRDCLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFG1</accession>
    <name>F4FFG1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_25825</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734915.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25825"/>
    <dbReference type="EnsemblBacteria" id="AEB46263">
        <property type="protein sequence ID" value="AEB46263"/>
        <property type="gene ID" value="VAB18032_25825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25825"/>
    <dbReference type="eggNOG" id="COG1718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060067_0_0_11"/>
    <dbReference type="OMA" id="REMRAMT"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO" evidence="12">
        <location>
            <begin position="48"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB46263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="34593" checksum="2A23E5CD418A6476" modified="2011-06-28" version="1">MRDHDFSARERHTRGKRRFDDDEPQFLKRGRARGPVPADPSDEPDPDTGAVWSSWDDAVHGPQPHPAWLVTDLAAKDTELGVLKTGKEADVHLVRRAVPDSDRSCVLAAKRYRDPRHRLFHRDAGYLEGRRVRRSREMRAMTGRTAFGRQMIAGQWAAAEFAALARLWEIGERYGTVAVPYPVQLRDTELMLEFLGDPDTGQAAPRLAELRPAGAELRGLWEQLVEALMVLARAGYAHGDLSPYNLLVHAGRLVLIDLPQVVDVVANPQGRDFLARDVRVVSTWFAARGLPASLAEPAALTGLLAREAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFG8</accession>
    <name>F4FFG8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uracil-DNA glycosylase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25860"/>
    <dbReference type="EnsemblBacteria" id="AEB46270">
        <property type="protein sequence ID" value="AEB46270"/>
        <property type="gene ID" value="VAB18032_25860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25860"/>
    <dbReference type="eggNOG" id="COG3663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042829_3_0_11"/>
    <dbReference type="OMA" id="FWPVLHL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000700">
        <property type="term" value="F:mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="2">
        <location>
            <begin position="45"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="22721" checksum="26E49619A6E380A9" modified="2011-06-28" version="1">MTVEPPAEQHRKARRGTGSGAALTPRPHPRPSREDLAAAVDRTLPDVIGTGLDVLFVGINPGLWSAATGWHFARPGNRFWPALHRSGFTPRLLHPSEQDSLPELGLGITNIVARASARADELTAAELVAGARELTGKVARYRPRWVAVVGVTAYRVGFARPKATFGRQPEPLAAAQLWVLPNPSGLNAHYTPETLAAAFAALREATGRQPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFQ6</accession>
    <name>F4FFQ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase s8 and s53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_02245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736167.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02245"/>
    <dbReference type="EnsemblBacteria" id="AEB47533">
        <property type="protein sequence ID" value="AEB47533"/>
        <property type="gene ID" value="VAB18032_02245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02245"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353324_0_0_11"/>
    <dbReference type="OMA" id="PVHHEAY"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="506"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="802" mass="82177" checksum="A6D05108983872AB" modified="2011-06-28" version="1">MRADYSSGSASSPGAVVATVLIGCWAVGVTVVSQTGGWAVDQVLLLTALDRLVLLWPLVSLLTVVAIGTAALPLAMVPRSATIRSTGRVWLAGTLTLGVLGLLRAIPPVHHEAYLAVLAVTATLLALVARWASGRVAGADRWPAPAQPRALRPSVATWLALAAGLALLVPWVWLGALGGLLETVVAGLAAAAVGALAAALLDARFWGHFTGGQPPRPARLVLLGGLVAGVVLLLVGAGTGQSGAQLPLLVALPPVGFALAALHALTRRHPRTAGRTWTAWLVGLTVFGPLAFTDPEEISLLLASTRDVPFWVAVATGAGLVVALVLAIAYGLLLARPAARPPRPALAGLTALVLLVAVGAIGVGVGQPGLHGERLFVLLHEQADLADLPAGTGKAGRDARAEQVYRRLVATAERTQAELRRDLRRLRLEHRPYYLVNAIEVDGGPVVRAWLSSRPEVARVLVSQRLRPLPAPAAPAVGDAPAPDGPPWNITMIGADRVWSALGVTGAGVTVGSSDSGVDGRHPTLVGNFRGGDDSWFDPWNGTRTPTDRSGHGTHTVGSAVGRGGIGVAPGANWVGCVNLDRNLGNPASYLDCLQFMLAPFPPGGDPFTDGRPSRAPEILTNSWGCPPIEGCDPGALRPATDALEAAGILVVAAAGNSGPLCDSVQDPPAPYPDVLTVGAVDQRRQVAAFSSRGPAPGGVAKPDLMAPGADVLSAMPGGGYATLDGTSMATPQVAGVVALMWSADPDLIGDLDRTRQLLRDTATVVPTGTDSAERTDACGGTRNVIGAGLVDAYAAVRAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFR8</accession>
    <name>F4FFR8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_02305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736178.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02305"/>
    <dbReference type="EnsemblBacteria" id="AEB47545">
        <property type="protein sequence ID" value="AEB47545"/>
        <property type="gene ID" value="VAB18032_02305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02305"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_2_0_11"/>
    <dbReference type="OMA" id="YFMAHAP"/>
    <dbReference type="OrthoDB" id="2025630at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="149" mass="15877" checksum="C9C0938B6103DA94" modified="2011-06-28" version="1">MRIDRFGGPALSLFRMVVGLLFLCHGLASLFGVFGGNRGTGEPVPLGQWPGWWAALIQALCGALVLVGLFTRPAALLASGSMAYAYFVVHQPEALLPLRNHGELSVMFCWSFLLIAILGPGSWALDNLLGQRGGRELALDAEARSSVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG03</accession>
    <name>F4FG03_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07295"/>
    <dbReference type="EnsemblBacteria" id="AEB42583">
        <property type="protein sequence ID" value="AEB42583"/>
        <property type="gene ID" value="VAB18032_07295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07295"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_296100_0_0_11"/>
    <dbReference type="OMA" id="CLANMGR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1078" mass="117018" checksum="4C38190442A01253" modified="2011-06-28" version="1">MPPFSVDEFVDPPAAGLQELIRSRRQPSVLLTARRQAIGFTGRVDELAALREWQDDPIVHGVWAWHAPGGQGKTRLAQRLGRLSVVAGWRVAVAAHRDAAPADVDASPLGSPWRWLPAARRPLLVIVDYAERWPLHDLRRLLADCRARAPKVRVLLLARSVDWWPTLSAELPRLGYTGGGDGGPRPLLALADDGPGRRDLFEAACRRFAEIYQPDMPERGWPGRWQPPSILSDDRVYGTTLGIHMTALATVDAYTRQAVPPGSAGDVTRYLLNRERAYWARLHGDAPDTVTAAARTVLLACLVGPQSRDDGLRLLTRTGLADDMVGQRLLDAHDRCYPPPNTATVLEPMYPDRLAEDFIALSLPASPTGEPVTASGHTDSWAATTLLTARRPPEGTLTYTSGPLTAYTAEQKPPAHTARILIFLAAAAGRHPHVHGWLHTLLATDPALPIHAGGIALSAVARYTNAALAEAIYALLPERSLDLDPAAAVLAQHLLDHTDGSDEQHARHTGNLSIRLSNTGRHQQALAPAEEAVTIYRRLAKANPDAYLPDLATSLNNLGAFLSGLGRREQALAPAEEAVTIRRRLAKAKPDAYLPDLAASLNNLGNRLSELGRREQALAPAEEAVTIRRRLAKANPDAYLPDLAMSLNNLGMILSGLGRREQALAPAEEAVTIYRRLAKANPDAYLPDLAASLNNLGMILSGLGRREQALAPAEEAVTIYRRLAKANPDAYLPDLAASLNNLGNRLSGLGRREQALAPAEEAVTIYRRLAEANPDAYLPDLATSLNNLGAFLSGLGRREQALAPAEEAVTIRRRLAKANPDAYLPDLAMSLNNLGMILSGLGRREQALAPAEEAVTIRRRLAKANPDAYLPDLAASLNNLGAFLSGLGRREQALAPAEEAVTIRRRLAKANPDAYLPDLAASLNNLGNRLSELGRREQALAPAEEAVTIRRRLAKANPDAYLPDLATSLWAYGWVCVNVKANYAEALESVTEAISLYEPLTRQLPQMFAGQLFSAYRTLADVLDGLGRTEEAAEMRRQLDELANRGRAPSKRAARDAPTTQTNSRRHGPSDRSPYDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGC3</accession>
    <name>F4FGC3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733716.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19795"/>
    <dbReference type="EnsemblBacteria" id="AEB45061">
        <property type="protein sequence ID" value="AEB45061"/>
        <property type="gene ID" value="VAB18032_19795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19795"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_11"/>
    <dbReference type="OMA" id="PLRIGTF"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="298" mass="31383" checksum="C400EF2C99E9DF62" modified="2011-06-28" version="1">MLDVRRLRLLRDLARLGTIAAVAEAHTYSPSAVSQQLAALQRETGVVLLERVGRGVRLTATATALVRHTEVILAGLEAAEATLAAARGGLLGTVRIGAYPSAVRPLLLPALVELAREHPGLDLLVTELDPVAVPAALRERRLDVALVHDYDIVPVQTDPALDSTPLLDETVFLALPATHPVPVDPMRVVRDADWIIGSPGTLCHAVTLHACDLAGFRPNVRHHADDFTAVLALVAAGQGVGLVPQLAVEGPPAGTRLVPLPIRRRTRIAYRQGAADHPAVLASIAALRGAAADLPEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGG4</accession>
    <name>F4FGG4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA alkylation repair enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45102">
        <property type="protein sequence ID" value="AEB45102"/>
        <property type="gene ID" value="VAB18032_20000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20000"/>
    <dbReference type="eggNOG" id="COG4912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079880_0_0_11"/>
    <dbReference type="OMA" id="NWDLVDT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="25376" checksum="952EA097A4C97AA0" modified="2011-06-28" version="1">MSRYLRMVPGGYGEGDRAIGVTVPEQRRVAGRYWRQLSLDDVATLLGGDVHEERLTAIFVLVRKFAKGDEVQREAIYRLVLANTERINNWDLVDSCAPYLVGPWLIDKDRAVLDRWAGSELVWERRMAIMATFAFIRAGDFGWTLRLAERLLGDPHDLVHKAVGWMLREVGNRDRAAAEEFLSRWHRDMPRVMLRYAIEKFEPERRQQYLSGVLTPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGW1</accession>
    <name>F4FGW1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Atpase aaa-2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_02685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736253.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02685"/>
    <dbReference type="EnsemblBacteria" id="AEB47621">
        <property type="protein sequence ID" value="AEB47621"/>
        <property type="gene ID" value="VAB18032_02685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02685"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_11"/>
    <dbReference type="OMA" id="ERMKAVM"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="846" mass="93873" checksum="D63EE31F10715FC2" modified="2011-06-28" version="1">MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEGVRQQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYQGKEPAAAGTAPGEAAPSTSLVLDQFGRNLTQAAREGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLSQKIIKGEVPETLKDKQLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDEIHTLVGAGAAEGAIDAASILKPMLARGELQTIGATTLDEYRKHLEKDAALERRFQPIQVGEPSLAHTIEILKGLRDRYEAHHRVSITDAALVAAATLADRYISDRFLPDKAIDLIDEAGARMRIRRMTAPPDLRDFDERIAQVRRDKESAIDAQDFERAAQLRDKEKQLLGQKAQREKEWKAGDLDVVSEVDDEQIAEVLGNWTGIPVYKLTEEETSRLLRMEDELHKRVIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALAEFLFGSEDALIQLDMSEFHDRYTVSRLVGAPPGYVGYDEGGQLTEKVRRRPFSVVLFDEIEKAHPDVFNTLLQILEDGRLTDGQGRIVDFKNTVIILTTNLGTRDVAKAVSLGFQASEDSESNYDRMKQKVNDELKQHFRPEFLNRIDDTIVFHQLRQQEILSIVDIMIARIETQLRNKDMGLELTDNAKKYLAAKGFDPVLGARPLRRTIQRDIEDNLSERILFNELIPGQIVVVDCEGDPNDIDKSKLVFKGSERPVDVPDAVPADLGGTATTGADETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGX6</accession>
    <name>F4FGX6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731263.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42590">
        <property type="protein sequence ID" value="AEB42590"/>
        <property type="gene ID" value="VAB18032_07330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07330"/>
    <dbReference type="eggNOG" id="ENOG5032VYS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107606_0_0_11"/>
    <dbReference type="OMA" id="YSSCWAT"/>
    <dbReference type="OrthoDB" id="1850905at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="201" mass="22444" checksum="C209F5C995C4481E" modified="2011-06-28" version="1">MTSPSMPEVRKVGRRAAEILDRMRAHPAYHRLHSSSMRYSSCWATFTGYPAISRWSLERDAGPLLEEALRVLALKAAVFELSDGDERAAELLVPAPVDEMIHAVLAQFTLMTRMQSDLAVVFPHATELEEFTYTRGCVTDAYYAAAGWGEQPLRYWLDSAEVTRRLDLLNAHYQAAGLGRDGRSHDFDFDQPEPVAVGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH10</accession>
    <name>F4FH10_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731297.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07520"/>
    <dbReference type="EnsemblBacteria" id="AEB42624">
        <property type="protein sequence ID" value="AEB42624"/>
        <property type="gene ID" value="VAB18032_07520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07520"/>
    <dbReference type="eggNOG" id="ENOG50336WS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058041_0_0_11"/>
    <dbReference type="OMA" id="RLTAWWS"/>
    <dbReference type="OrthoDB" id="1643101at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025855">
        <property type="entry name" value="Replic_Relax"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13814">
        <property type="entry name" value="Replic_Relax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="291" mass="32603" checksum="6BDB6985F8FA3FA3" modified="2011-06-28" version="1">MYSRVPRASSKPDALAVFGRIVPRDHALLALLAEHYLLSTDQITNAFFDSRRTAQRRLTILHRLDVLHRFGRSNHNGRYGSLLYTLGPVGLQLHPTTYHDPNGTGGKPPRSSLERAKRIAASGQVNHLLGVNQFFTDLIATARRSTDARLSRWWSEQHATTVYAQAGIRPDGHGVWTIGDTSTGFFLEHDNDTENLARVVAKLRGYERLTTFGPRYPVLFWVPSRRREASLLGVLAGLRTTSPIATAIHGPDPAGRVWTLVSDPTHRRYLHELPCDHGPDTVTNPQRFENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH37</accession>
    <name>F4FH37_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_07655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731324.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07655"/>
    <dbReference type="EnsemblBacteria" id="AEB42651">
        <property type="protein sequence ID" value="AEB42651"/>
        <property type="gene ID" value="VAB18032_07655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07655"/>
    <dbReference type="eggNOG" id="COG3947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433339_0_0_11"/>
    <dbReference type="OMA" id="IHARRND"/>
    <dbReference type="OrthoDB" id="229486at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="3">
        <location>
            <begin position="512"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="649" mass="68924" checksum="EBD9DF757144797F" modified="2011-06-28" version="1">MRWPRRLASALMVVVLLVGPPLLLVRLVGWPAIGGPRVAIWGWVRDPLTEQNLVLMVVVLAWALWAFVAYTVTVRTAVRLWAGVRWLRRLPLPTPWQATATGVAGAAALTIATPSTLTSGPDHPATEVGAGYIHDRDGVDQAASSDGVVVVGGWLPRAVADQVGVAVGLLWLRRRLAYRPRRASEDADDLAPLPATVAAIQAATTVRPDSPPPQPSAVVGVLPPGFPAAGVGLSGPGALAAARGLLVTVLLAALRQDSARLVITRRAAQVLLGPEAAFLRPGSGLWIADTVTHATTMVTAASQAAPSSPGGRSVLILDGPPPDTLVTEVATVVVLADWPQATTWHVAADGYTQALDAMASGPRVCVLDPVAAADLLTVTGHLNPIVRDARPQPVPQARIPRQPGPRHDGGEVGRRLRARVLGEPVLLCDGTPLLLRRTAARQALVFLAVHVDGVDSHVMAEALWPGLPAHRLTGRLYTTLSELRTAVRAATDLPLIDRTGDRYRLHPDHVDVDLWHLRAAAAHAASTLTDPATAWRAVIDAYTGDLAAGHSWPWLDAYRETARRLVLDAYTALADTEPDPRRALAHLQDGIRVDPYNADLHQRAVNILAGLGEHTAAADLAERYKRGLIAAGLNPDHVLQVALLHGRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHE2</accession>
    <name>F4FHE2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cyclic nucleotide-regulated ABC bacteriocin/lantibiotic exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_20060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733769.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20060"/>
    <dbReference type="EnsemblBacteria" id="AEB45114">
        <property type="protein sequence ID" value="AEB45114"/>
        <property type="gene ID" value="VAB18032_20060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20060"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="VRRQCGV"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="170"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="480"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="514"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="717" mass="75890" checksum="93798FD94CFFAE37" modified="2011-06-28" version="1">MTTVDPTMDTLTAERTDTAVSRAAADLAAVDEAWRRLAAAAAERPERPDDDAARTLAAHYDLPSPTPGTGLVTALRAAGLHWTEVRLDGHWYRRGAAPLIVFPVSGPAVALLPTRGGYRTAHGRRVTAADAGAYDRTAWQVYPPLSAGPPVTTRHLLRFAARGAGPDLRFLLTAGLLAALIGGVLPFLSAWIITGVAGGSVGGQLLWSLAALIASFVVANALLLSARNAALVRLQGRLQLRLEPAVWSHLLSRDLRALEEMGTSDLVQRANSVTEMRKALSDSVAAGVLGSAFGLVSLAALIFVDPVVGGCVLVATLLLMAAASYAAIRQQRHELANREAFAAVAGFLHTALLAIEKIQVAAREERIFAGWAQRYARQRSTDAATLRWQARVAACSAALQPTLLATLGIVVALRQDVALGTFVAASIAVGQFAASVGMLQGGVISAFSLVAAYRRLVPVLTAAPDVTPGAADPGRLRGRVQLHEVTFTYPGTGRPVLDRVSITAEPGEFIAVVGPSGAGKSTLIRLLLGLVPPSSGAVRYDGRDLSELDVRTVRAQLGVVLQQARAVRGSIRDNVAAGTEDLTDEAVWQALRLAGLADEVRDMPMGLHTMVSEDNKAFSGGQIQRLMVARALAKQPPVLVLDEATSALDNITQRKVTDRIADLDVTRIVVAHRLSTIRAADRIYVLDNGRIVAEGTFDHLVATAPLFARLVARQEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHK0</accession>
    <name>F4FHK0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CsbD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733827.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20360"/>
    <dbReference type="EnsemblBacteria" id="AEB45172">
        <property type="protein sequence ID" value="AEB45172"/>
        <property type="gene ID" value="VAB18032_20360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20360"/>
    <dbReference type="eggNOG" id="COG3237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135567_1_2_11"/>
    <dbReference type="OMA" id="IGDMADN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="6820" checksum="F57D29AC0C7EC559" modified="2011-06-28" version="1">MSFIDKAKNKVEEMSGTAKERIGDMADNERMRAEGAGEQAEARARRAGEDMKNKAKNAFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHM2</accession>
    <name>F4FHM2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="4" type="ordered locus">VAB18032_26571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735042.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26571"/>
    <dbReference type="EnsemblBacteria" id="AEB46391">
        <property type="protein sequence ID" value="AEB46391"/>
        <property type="gene ID" value="VAB18032_26571"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26571"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_2_2_11"/>
    <dbReference type="OMA" id="DIAVWMV"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="414" mass="43320" checksum="B04F7B0B7F8C6244" modified="2011-06-28" version="1">MSLASPTYLAAIPSPSTAVWHLGPIPLRAYALCIIAGIVVACWVTDRRLRQRGVAPGAVLDIALWAVPAGIIGARIYHVITSPAAYFGTGGDPIKVFYIHEGGLGIWGAVAGGAVGAWLAARQLGIPFAVVADALAPGLPLAQAVGRLGNWFNNELYGSRTDLPWGLEIHRMDGGQALRDEAGRPILEEGLYHPTFAYEALWNVGVAALVFFLDRKLRLGRGRAFALYVMGYTAGRFWIEMMRTDEANTILGVRLNVWTAALVFLGALAYFLLVRGPRQYLIPIGASVATSTAASDVSQVDLSARQAGEQPVAPEGYRVVSEEQFRHWQETGEAPPEPTGTDDPATGTTTDASGTSTTTGASGTGTASTGDAATGESVTAAGRSDDAATAEERPGDAATDGGAAASARPAERDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHT8</accession>
    <name>F4FHT8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_26921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26921"/>
    <dbReference type="EnsemblBacteria" id="AEB46457">
        <property type="protein sequence ID" value="AEB46457"/>
        <property type="gene ID" value="VAB18032_26921"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26921"/>
    <dbReference type="eggNOG" id="COG4544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074514_2_1_11"/>
    <dbReference type="OMA" id="LVPYGRW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="236" mass="24235" checksum="99BE22E859D58D24" modified="2011-06-28" version="1">MVVGSAALAALVRPASAPDPAGGHRMLPVRPELSGLLPGRGLRRGSTIAVGVGQPRHSGTTSLLLALLAEASRAGSWCAVVGMPTFGPGAAAEAGIALDRLALVPQPGPEWPTVVAALIDGVDVVVTAVPAAVSASVAGRLAARARQRGSVLVPYGRWDGADVTLQVVRGVWEGLGSGRGRLRRREVTISARGRGAAARPKELTVWLPGAELTRVIPRSSAPRDNHAAIMHLRSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHW8</accession>
    <name>F4FHW8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736293.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02885"/>
    <dbReference type="EnsemblBacteria" id="AEB47661">
        <property type="protein sequence ID" value="AEB47661"/>
        <property type="gene ID" value="VAB18032_02885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02885"/>
    <dbReference type="eggNOG" id="COG5282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059556_0_0_11"/>
    <dbReference type="OMA" id="QFTAVPW"/>
    <dbReference type="OrthoDB" id="1070352at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="38825" checksum="1BD1E431743331D0" modified="2011-06-28" version="1">MAQFVDWDLAVATAGALGKTGPRVSYDEATEVVAELRRLTDEAAGHVADYTGLTSQVAHPPVRVVDRRDWAATNVAGLREVITPLVGRLASDKQPGVLTEAVGSRVTGVQAGTVLAYLSGRVLGQYEVFSADPGQLLLVAPNIVEVERKLQADPRDFRLWVCLHEVTHRTQFTAVPWMRGYFLGEVQAFVDAAQGSEHLLDRLRRGVGTLADVVRNPQGRSSVLDIVQTPGQRAVLDRLTALMTLLEGHAEFVMDGVGPQVIPSVERIRAGFNRRREAGNPVEKTVRRLIGMDVKMRQYAEGRKFVHAVVERVGMAGFNRIFESPLTLPRLSELSEPDAWVARVHGPVGPKPPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F117</accession>
    <name>F4F117_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731344.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07755"/>
    <dbReference type="EnsemblBacteria" id="AEB42671">
        <property type="protein sequence ID" value="AEB42671"/>
        <property type="gene ID" value="VAB18032_07755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07755"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2439964_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="90" mass="9646" checksum="0A990D5255CD0EB9" modified="2011-06-28" version="1">MTDNEADDQIACSAPGLMETSKGGNTWLFSGAVPGQPFSAEQLTHRLNALGIRIRAARNTTLIDLASEVPAVVLSQLLGLHVRTTTDWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1D5</accession>
    <name>F4F1D5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732638.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14295"/>
    <dbReference type="EnsemblBacteria" id="AEB43971">
        <property type="protein sequence ID" value="AEB43971"/>
        <property type="gene ID" value="VAB18032_14295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14295"/>
    <dbReference type="eggNOG" id="COG1503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133101_0_0_11"/>
    <dbReference type="OMA" id="MQRGSDR"/>
    <dbReference type="OrthoDB" id="1789188at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="138" mass="14794" checksum="A1C4B81435BA62F6" modified="2011-06-28" version="1">MDRGNSKHAPRVDEQMSQEVNGLVQGPGTGGSRVDESRVPEPAGEDQPEATTAPGGDLRSGTPQGMTSEDVEARSRLGRFITMTALPGDRAALLANARENEAPDDVIAALERLPDGTRYQTVSEVWAALGHKNETTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F237</accession>
    <name>F4F237_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736416.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03500"/>
    <dbReference type="EnsemblBacteria" id="AEB47784">
        <property type="protein sequence ID" value="AEB47784"/>
        <property type="gene ID" value="VAB18032_03500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03500"/>
    <dbReference type="eggNOG" id="COG4842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151185_2_0_11"/>
    <dbReference type="OMA" id="APLYDQW"/>
    <dbReference type="OrthoDB" id="1999616at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="109" mass="11655" checksum="BFBB139CCF45F99C" modified="2011-06-28" version="1">MSMRTDTGLMLKTEGDVDAVADRLTSNLNGLMDQLAPLYDQWKGAGAGSFQQVRERFDQDMARLNVALRAIAEAVGSAGKDYDVSDEEIRADMDSAGATAGQITAALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2E0</accession>
    <name>F4F2E0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative muramoyl-pentapeptide carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14500"/>
    <dbReference type="MEROPS" id="M15.001"/>
    <dbReference type="EnsemblBacteria" id="AEB44012">
        <property type="protein sequence ID" value="AEB44012"/>
        <property type="gene ID" value="VAB18032_14500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14500"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119635_0_0_11"/>
    <dbReference type="OMA" id="YWSAPTC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013230">
        <property type="entry name" value="Peptidase_M15A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08291">
        <property type="entry name" value="Peptidase_M15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309022" evidence="2">
        <location>
            <begin position="38"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_3" evidence="4">
        <location>
            <begin position="122"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="26251" checksum="E0435924DAB36A15" modified="2011-06-28" version="1">MERRTVRHRLVSALTACALAALASLAAVTATGAPAQADACYTWGRTLSSGMTGEDVRQLQIRVSGYPGYGAVLTLDGAYGPATRSAVIRFQQAYGLAADGVAGAQTFNQIYALQDPDCTPVSFSYAEWNRCNSDWSGGAVSASTARFNALVSMWKLQAMRRAMGNAPLYLSSGFRSYSCNSAVGGASNSRHLYGDGIDLVGSHSFCALAQQARNHGFTNILGPGYPGHNDHTHLGNTPSRSWSAPSCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2N0</accession>
    <name>F4F2N0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733949.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20975"/>
    <dbReference type="EnsemblBacteria" id="AEB45295">
        <property type="protein sequence ID" value="AEB45295"/>
        <property type="gene ID" value="VAB18032_20975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20975"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_2_11"/>
    <dbReference type="OMA" id="AWDTVEN"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="23992" checksum="D4BD25ADBF8B91D4" modified="2011-06-28" version="1">MTHPSSVGRTAAPSAAERAYRHLKQAILEQVHPGGSLVSEGEIAEATGVSRTPVREALLRLETEGLVRLYPKRGALILPVSAREITDVIEARRLVEVHAAEQVWPRRAEIRADLAARLAEMRAAHTAGDLTALMAADRAFHATVVDAAGNEILAELYQRLRDRQLRMGETTFRLSPRWADMALTDHAAQLAALDADDPGPWLATVATHIDNAARALRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Y3</accession>
    <name>F4F2Y3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_27606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735244.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46594">
        <property type="protein sequence ID" value="AEB46594"/>
        <property type="gene ID" value="VAB18032_27606"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27606"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_7_0_11"/>
    <dbReference type="OMA" id="FGPVNWA"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="253" mass="25667" checksum="72D6283ED3DC8A8C" modified="2011-06-28" version="1">MDLANAALLLAAGMAAGTVNAVAGGGSLITFPALLAVGLPPVPANVTNSVSVFPGYGAAVAGSWMDLPRGRLLVTLVPTTIVGALVGAGLLLVTPARAFEVVVPFLVLGATALLAFQDPLRRLVGHPRDVPTRRRGLTIQVVVALASVYGGYFGAAVGVMLVAALALVLDATLARVSAIKNLLSAIIGLTTVAVFALAGPVNWAGVALLAPATLVGGYAGARLVRRLPSKLLKAIIVVFGTTIGLYLLWRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F305</accession>
    <name>F4F305_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735266.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27716"/>
    <dbReference type="EnsemblBacteria" id="AEB46616">
        <property type="protein sequence ID" value="AEB46616"/>
        <property type="gene ID" value="VAB18032_27716"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27716"/>
    <dbReference type="eggNOG" id="ENOG5031Y1M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117223_1_0_11"/>
    <dbReference type="OMA" id="VGKDWSG"/>
    <dbReference type="OrthoDB" id="1912696at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021412">
        <property type="entry name" value="DUF3052"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11253">
        <property type="entry name" value="DUF3052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="145" mass="15390" checksum="B3B722D24EDEF3E5" modified="2011-06-28" version="1">MSATAGQAADGVRSLADRFGIEPGMVVMEMGYDDDVDADLRDALTDRCGDLVDEDTDEVVDAVLVWYRDGDGDLFELLVDALGPLADNGVVWLLTPKAGRDGHVEPSEIAESAPTAGLQQTSTVNAGKDWSGARLVLRRGAKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F335</accession>
    <name>F4F335_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736446.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03660"/>
    <dbReference type="EnsemblBacteria" id="AEB47814">
        <property type="protein sequence ID" value="AEB47814"/>
        <property type="gene ID" value="VAB18032_03660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03660"/>
    <dbReference type="eggNOG" id="COG3546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057467_1_1_11"/>
    <dbReference type="OMA" id="IAHQKSF"/>
    <dbReference type="OrthoDB" id="1420351at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01051">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039377">
        <property type="entry name" value="Mn_catalase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="31573" checksum="77FB28CBD553D4F9" modified="2011-06-28" version="1">MFSHIKNLQFEAKPDGPDAAFARRLQEVLGGKWGEMTVANQYLYQGWNCRLPGKYKDLLLDVGTEEMGHVEMIATMITRLLEHAPLSLAEAAEGNPMVGAIYGGSNPAHFIHGGGGAMPVDSVGVPWNGNYVTASGNLMADFQLNVTAEAQGRLQVSRLFNMTDDPGVKQMLRFLLARDTMHQNMWMAAIEQLKEDGLEGMPVPDAFPDSPDFTEEFSYTYLDFSPDGDAGQGRWASGPAPDGKGEFRYDHSPRAHAPEPVLPPGDPRLYGTDPGMVQGVMNKVKSKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3A2</accession>
    <name>F4F3A2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galK</name>
        <name evidence="15" type="ordered locus">VAB18032_08540</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731497.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08540"/>
    <dbReference type="EnsemblBacteria" id="AEB42826">
        <property type="protein sequence ID" value="AEB42826"/>
        <property type="gene ID" value="VAB18032_08540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08540"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_11"/>
    <dbReference type="OMA" id="PVCYNLR"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="14">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="119"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="288"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="128"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB42826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="389" mass="40697" checksum="27A3EBBFB7F69C90" modified="2011-06-28" version="1">MTGAARTVADRAAAGFHQVYAEPPAGRWAAPGRVNLIGEHTDYNDGFVLPFALPLRTVAAAAPQPGETWTVWSELTGETVDFGAAEVTAAGRVTGWAGYVAGIVWALREAGYPVPGARLAIASDVPLGAGLSSSAALEAAVLAALADLGGLDLPAEAQPRLAQRAENRYVGAPTGIMDQSAAIRCRAGHALFLDCRTEQVEHIPFDLAAAGLAILVIDSNAPHRHVDGEYAARRNSCEKAAALLDVPALRDVPTDNLDDALARLPDDETRRRVRHVVTENQRVYDTVDLLRARQIQQIGPLLVASHTSMRDDFAITVPEIDTAVEAALAAGALGARMTGGGFGGCVLALVEANHSDTVANAVTDAYARRGFTAPTHTTVTPAAGATRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3C7</accession>
    <name>F4F3C7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731522.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08665"/>
    <dbReference type="EnsemblBacteria" id="AEB42851">
        <property type="protein sequence ID" value="AEB42851"/>
        <property type="gene ID" value="VAB18032_08665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08665"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_1_0_11"/>
    <dbReference type="OMA" id="EHQYIAA"/>
    <dbReference type="OrthoDB" id="1635544at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13313" checksum="627EA88D172D6E3A" modified="2011-06-28" version="1">MDRDEPTGALVRPYAVTRGRTRPRLDIALEALVETTVRGRAVATGNGGQGREHQYIAALCDGRVQSLAEIAARMQLPLGVARVLIADMATDGLVAVHEPTILDDSDDAVGTELLERVLSGLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3L4</accession>
    <name>F4F3L4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732787.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15050"/>
    <dbReference type="EnsemblBacteria" id="AEB44122">
        <property type="protein sequence ID" value="AEB44122"/>
        <property type="gene ID" value="VAB18032_15050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15050"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1037418_0_0_11"/>
    <dbReference type="OMA" id="LICDTTR"/>
    <dbReference type="OrthoDB" id="1784761at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="35852" checksum="F040B2AD533F2B4C" modified="2011-06-28" version="1">MTVRQSIVFNGDLGSGKSTVSVEIAKRLGLRRVSVGDLYRQMAQERQMTALQLNLHAELDQAVDGYVDQLQRDIAASGESLVMDSRLAWHFFTDALKVHMITEPGEAARRVLLRPSGPAESYTSLEEAKAKLRERSESERGRFLVRYGVDKARLRNYDLVCDTTRAPADEVIERIVDVYEGRLAPEVLRTAPPLLLLDPARVYPTEDVAGLRGLWDSTDVGAVAEAGETGLEPLELGYTGEYFFVINGHRRLSAALRNGFRLVPGRLVAEVDEPVVGTTSAVDFFAAQARPSLIHDWEAAHDIRLPLPEHALLAGDAVLAGEPGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3L9</accession>
    <name>F4F3L9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum_form domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732792.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15075"/>
    <dbReference type="EnsemblBacteria" id="AEB44127">
        <property type="protein sequence ID" value="AEB44127"/>
        <property type="gene ID" value="VAB18032_15075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15075"/>
    <dbReference type="eggNOG" id="ENOG5030VN0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080960_0_0_11"/>
    <dbReference type="OMA" id="GVQCFLW"/>
    <dbReference type="OrthoDB" id="1953080at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026004">
        <property type="entry name" value="Septum_form"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13845">
        <property type="entry name" value="Septum_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313564" description="Septum_form domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Septum_form" evidence="2">
        <location>
            <begin position="49"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="31661" checksum="3D9A9B9F1119FD9B" modified="2011-06-28" version="1">MRRWLTGIALGTVVTLALAGCTKPAGIDGDLSDDWAPMAAAEVFTPDSGTCHTQVLDVGYVGAYDPVACDQPHRVETLHVGALTSDDGATPPAVGSAPMRTAFSECNRQVRTALGADWRSARVWLSVVFPSPAAWGGGARWFRCDVTELRGLDNPDPVLRKASLAGALSGTSPLRHGCFNAKTSGDKVTEMVAVKCTARHRAEFVGVWTAPKGSYKAFLDNADRAHRACRSLIAKFAKLPDDNNVQYRAGTIFYHPAEDDWRNGNRGVQCFLWSSERVLTRSMKGAGSRALPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3S8</accession>
    <name>F4F3S8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_21395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734032.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21395"/>
    <dbReference type="EnsemblBacteria" id="AEB45379">
        <property type="protein sequence ID" value="AEB45379"/>
        <property type="gene ID" value="VAB18032_21395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21395"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_10_2_11"/>
    <dbReference type="OMA" id="QRRFHVM"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026335">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04269">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="399" mass="43882" checksum="529B95026BAFFD11" modified="2011-06-28" version="1">MPESDDGHRTAGDSAVRRAPPVAFRQFVLKLHSRCDLACDHCYVYTMADQRWRDLPRIMSPRVLDATARRIGEHARAHRLDTVSVILHGGEPLLAGPARIESAVSAIRQGVAPVPTRLTVQTNGIRLDEAYLRLFDRLDVRISLSLDGDRAAHDRHRRGPDGRGSHDRVDAAIRRLTTGYPHLFNGLLCTVDLRNDPVTTYRSLLAHRPPTMDFLLPHGTWSTPPPGRVPKPRPTPYADWLITVFEQWYHAAGPPVRIRLFDEIIQVLLGGHSRLAGVGTSPAAVAVVQTDGAIEMDDTLAAAHSGAARTGLHVLRDRFDDALDLPAVRAQQAGSASLCATCQACDRRRVCGGGLRTHRWRADTGFDNPSVYCPDLYALIGHIGRTIRRDLAVLSGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3S9</accession>
    <name>F4F3S9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734033.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21400"/>
    <dbReference type="EnsemblBacteria" id="AEB45380">
        <property type="protein sequence ID" value="AEB45380"/>
        <property type="gene ID" value="VAB18032_21400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21400"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018916_0_0_11"/>
    <dbReference type="OMA" id="HETHHTK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="437" mass="46769" checksum="050C9C9699CF5394" modified="2011-06-28" version="1">MIPGEHRLPRVVLDELAAGRGGADGVAWLRAAQHSKSMLLVRAIIALLRERGHPDRAAIEAAYRLLAGLRPEQRATALGHPPVAAWAFGTAALLDGDGTAQAYPGLLAAVAATAAVRAGLEADLDVPLAVGAAGRLDLPGLGTATLPDAATHARVRASRGHAWAYGAGERVEIGAGSTDRRWRPVPRLDLAHHGLRLSLLLDTRSWQHVPGIGTGHRISGGLTDAWRSRLDEAWRLLVEHHRPVAEELSGALRALVPVPSPGAGSRSGTFHHAFGAVAMSLPPDAPSAAVVLAHEIQHAKLAALNDMFALLEPGPPELFYTPWRTDPRPLEGLLHGVYAHLGVAGFWRRQARVTVDGAARYRAEVEFARWSRAADDTVRVLAAQRRLTPVGRHLVDGMAAVLADWAAEPVSPPAAQRAHRLLAEHRERWGRRRAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Y0</accession>
    <name>F4F3Y0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27766"/>
    <dbReference type="EnsemblBacteria" id="AEB46626">
        <property type="protein sequence ID" value="AEB46626"/>
        <property type="gene ID" value="VAB18032_27766"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27766"/>
    <dbReference type="eggNOG" id="ENOG5031HUI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1276861_0_0_11"/>
    <dbReference type="OMA" id="QTYDLYP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309070" evidence="2">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="206" mass="21902" checksum="4616E6185F23C123" modified="2011-06-28" version="1">MALGGLAAMLLSLTVAEPAKAAPKSPPAGVDITGHGLAEPLRLRAEQHPEHVKAIVDQVSAKVLVRQPGSPKKANLGPKYTVVVLAGDVPKQTYDLYPKAVGGPRVYRPAKQPDSRKTTAAWFLGRVTMSETLRTAGVPLERTYEAVSGGIGGGERIIPEDTLNPAQDINEAFGELRRLLLLNVAVVVVITLGLAGIALLIRRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Y1</accession>
    <name>F4F3Y1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735277.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27771"/>
    <dbReference type="EnsemblBacteria" id="AEB46627">
        <property type="protein sequence ID" value="AEB46627"/>
        <property type="gene ID" value="VAB18032_27771"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27771"/>
    <dbReference type="eggNOG" id="ENOG5031WTQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2037088_0_0_11"/>
    <dbReference type="OMA" id="WAGAHRH"/>
    <dbReference type="OrthoDB" id="2056361at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="13216" checksum="258A9EB412E46178" modified="2011-06-28" version="1">MAQGDAEYGCAQDEPSRPGAHEQPATAKHHHRRPTGLSQPADAHAGWTPERGDEEPAVARPGPTEPAVPRQRAAEPPVEPDEPDASGCRSEQPGWAGAHRHGPVRPARRATRRERPPRRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F415</accession>
    <name>F4F415_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735311.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46661">
        <property type="protein sequence ID" value="AEB46661"/>
        <property type="gene ID" value="VAB18032_27941"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27941"/>
    <dbReference type="eggNOG" id="ENOG503216J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136748_0_0_11"/>
    <dbReference type="OMA" id="RGDVYPS"/>
    <dbReference type="OrthoDB" id="2076047at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="13446" checksum="08DA529F6ACB752E" modified="2011-06-28" version="1">MSSYRDPAPRGDVYPSEEEIDPGGSGVEPASGPAGAYASDVASQPGPQPNPTPGPAPTPVPTPGPPPRQAGGGRSIVSRHLDGSVQVVTDVDGDGVADVVQFDLDGDGIPDVTYLDSDRDGRLDTVVRSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F424</accession>
    <name>F4F424_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ECF subfamily RNA polymerase sigma-24 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_27986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27986"/>
    <dbReference type="EnsemblBacteria" id="AEB46670">
        <property type="protein sequence ID" value="AEB46670"/>
        <property type="gene ID" value="VAB18032_27986"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27986"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_1_11"/>
    <dbReference type="OMA" id="NWLITVA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="93"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="418" mass="45642" checksum="8AECAFFF8EA4EB6B" modified="2011-06-28" version="1">MLVRRYGDFSAAEDAVQEAIVAAVETWPRDGVPEHPAAWLHTVAARRYVDHVRSEVARARRERTVLDTTGRDALVGPPSDADVPRDDLLELFLLCCHPALSTSAQVALTLRAVGGLTTAEIAAAFLVPEKTMNQRIFRAKQRLREVGARFELPPEAEQSARLAAVRQVLYLIFNEGYSASSGPQLHRSDLTRRALWLTRRLHDRLPDDGETTGLLALMMLTEARSAARVGPDGELVPLTEQDRRRWDRRAIAEGSALVERALTTSTPGPYQIQSAIAAVHAEASTTEETDWPQVLALYELLERLAPNPVATLSRAVAVGMVHGPAAGLALLAQLESGILAGHHRLHAVRAHLLELAGDRASAATAWRQAAELAAGSDPERRHLLRRAAAASDSGRIEGDHQGSGMFTARQRWVLRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4H8</accession>
    <name>F4F4H8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tripeptidyl-peptidase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_09090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731607.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09090"/>
    <dbReference type="MEROPS" id="S08.026"/>
    <dbReference type="EnsemblBacteria" id="AEB42936">
        <property type="protein sequence ID" value="AEB42936"/>
        <property type="gene ID" value="VAB18032_09090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09090"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282117_0_0_11"/>
    <dbReference type="OMA" id="WVTATDP"/>
    <dbReference type="OrthoDB" id="66120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312683" evidence="7">
        <location>
            <begin position="37"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="189"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="PPC" evidence="9">
        <location>
            <begin position="940"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1088" mass="112574" checksum="051C1CC763063EB4" modified="2011-06-28" version="1">MSRPRNLSRRTSAALFASVMAAGAVSVVGGTATASAAPAGTDPAQVTPAEALGEHDAKLLAEAEAKKAPTVTMIVATDKGKAKDVADDLKDLGAAVTERYDTIGYVLAKVPTSKAVKAATLPGVAAVDLDEKIQLPDPKPEVVQGGKKGDKQGSTLSGPGANTPADNPYMPTGETGAVKFVKSNKKWDGRGVTIGIMDSGVDLEHPALQQTTTGERKIVDWVTATDPLEDASWRPMLNQVTGPSFTLAGRTWTAPAGTYRFNLFSESITNNSEPAGDVNRDGDRTDQWGVLYDPVTNNIWVDTDQDGDFTDEALMRPYKEKFDVGYFGTDDPATPVKERMSFVVEYRKNVDTTPAGGPGLVDYVNIGIIESAHGTHVAGITAANSMMGNSAFNGAAPGAKIVSSRACSWGGGCTYAALTTGMADLVINRGVDVINMSIGGLPALNDGNNARATLYNNLITTYGVQMFISAGNSGPGVNTIGDPSASSNVVSVAASVSKDTWLANYGSVVKKKNALFNFSSRGPREDGGAKPNIAAPGSAISTTPVWQAGGPVAEAGYALPPGYSMFNGTSMASPQAAGAAALLLSAAKANHLGVTPEALRRAIYTSAKPIADTPTYGQGYGMFDVPGAWKLLRKGVQTRSYTADAPVCTPLSGQLATPNQGTGIYNRCDSANGGHKINQSKSYQVKLTRTSGPAGNIKHSIGLRGNNGTFSAPKDVTLPLNQTVTITVTAKPKTAGAHSTIVTVDDKATNTIDFEFSAVVVASNDVAKPNFAYSAQGSVDRNHTTSYFVTVPPGAGALQVNLSGIATASQTRFIAINPYGVPVESTSSLACFTNHVSTVVCNPFERDYANPMPGIWEIEVESRRTSPSLNNPFQIQARVQGVAVEPAVVELPSVTTGTPTPVTWSLKNTFGPVTVTGQGGSLSSTHTERPTIVELAVQEFTVEVPAGATSFTARIGNVSNASADLDLFVYRGGALVAYNADGDSEEFVTLNNPAAGTYTVVVEAYSVDGAGGSTAYDYRDSYSSPALGTLTASSSSLTLAHGATGTLTGTVTAQSAPPAGRTLSGELAVVTSEGAVVGRGAVNIGAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Q6</accession>
    <name>F4F4Q6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 4">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_15430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732863.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15430"/>
    <dbReference type="EnsemblBacteria" id="AEB44198">
        <property type="protein sequence ID" value="AEB44198"/>
        <property type="gene ID" value="VAB18032_15430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15430"/>
    <dbReference type="eggNOG" id="COG0686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_11"/>
    <dbReference type="OMA" id="HPYYHLY"/>
    <dbReference type="OrthoDB" id="673280at2"/>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="9">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB44198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="371" mass="39443" checksum="9CDD270698DDE672" modified="2011-06-28" version="1">MKVGIPREVKNHEYRVAITPAGVNEFTRNGHQIFVEAGAGVGSSITDEEFAAAGAKILDTADEVWETAELVLKVKEPVAEEYHRMREGQVLFTYLHLAASPDCTQALLDRKVTGIAYETVELPDRSLPLLAPMSEVAGRLAPQVGAFYLMRTGGGRGVLPGGVSGVYAAKTVVIGAGVSGMNAAAIALGLQSEVLLLDMNVGRLRQADAIYRGHLQTVTSNAYEIERAVLDADLVIGAVLVPGAKAPKLISNELVSRMKPGSVLVDIAIDQGGCFEDSRPTTHADPVYKVHDSIFYCVANMPGAVPNTSTYALTNVTLPYALELANHGWREASRRDPALALGLNTHDGQVVYGPVAEAHDLPTTPLAEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4V0</accession>
    <name>F4F4V0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_21695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21695"/>
    <dbReference type="EnsemblBacteria" id="AEB45439">
        <property type="protein sequence ID" value="AEB45439"/>
        <property type="gene ID" value="VAB18032_21695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21695"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="REFVEYM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="263" mass="28066" checksum="C03A7E87581DD0F1" modified="2011-06-28" version="1">MSAAETAATVHPWAIHAEALRVRAGRHLAVNGLDLALSTGVHGLLGPNGAGKTTLIRALATVLAPAGGQLTLLGRSVGGRSDLRSVRRALGYLPQHFGFYPRFTVREFVGYMAWLKEMHKADIPAAVQRAVDRVGLTAKADARMKTLSGGMLRRAGIAQAIVNDPQLLLLDEPTVGLDPEQRLDFRELLRDLGTDSCVLVSTHLVEDVVAACTDVVVVNEGRLVWQGTPDALAAQGAKGDAGDSPAERGYSALLRRQRMEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4W0</accession>
    <name>F4F4W0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor kinase, two-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_21745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21745"/>
    <dbReference type="EnsemblBacteria" id="AEB45449">
        <property type="protein sequence ID" value="AEB45449"/>
        <property type="gene ID" value="VAB18032_21745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21745"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021898_1_0_11"/>
    <dbReference type="OMA" id="LQNTAWI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="522"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="725" mass="75200" checksum="06517107EB14EA34" modified="2011-06-28" version="1">MTDPAGSGPDPAGGPAVEDAMAMADPDRGRPVVAWLVLALTGGLTLGAAVAGTVAAPPWRSDLLWWLVDLTVGTGFGLVAWLTLLRRSHPAAGLAALVGVGAAASAAAAGWAASAHRWPYLWAPEIPPAGAGFVPAWSALIVVLPWLLPVRPVGRSVRIVVGAAVAAQVFLSTVRYGWVPDELVGSVRDTLALALGPGLPAVLAVLGFAAAAGVLARRRALLPWQRHGLGWLAVGTLLHALALLGSTLDPVLPRGVPVAPLLMLAAQAFLPASVLVLVLRQRLWGLAHTVRQTLVWALTTGLLIGGYALGVVTLGSLLPATSVLPEVLTTAALAAVFHPVRQWVQRRVDRLVHGGGGQPLIRQVADRLRDVDGGMQMLDAVADGIADSLGLATVTITVTGNPGGWLPAQWLSGACPSPPSTGPGPAVPATGPTPSTSATGPGRAHGSTTSGTVPPLTIRLVAGDRLVGVLRAWPRTGERVAGRAASVLADLAPVLAALAELAVAQQALQRSRLQLARGRDEERRKLRRDLHDDLGPVLSGVSLGLAAGRNMLRPHRHLPAVAAADDLLERLVAEVDRQTVAVRDNARDLLPPLLDDGALRPALERLRQRYADAGLLLRVRSPEVNLPEPVATAVYGIVAEAVRNVHRHADVDSCTVEVTNGPEGLEVSVVDEGRGIAPGAAVGVGTRSMQERAEGISADLSIGPLHARPVRPGTRVRLLLPGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5M1</accession>
    <name>F4F5M1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15610"/>
    <dbReference type="EnsemblBacteria" id="AEB44234">
        <property type="protein sequence ID" value="AEB44234"/>
        <property type="gene ID" value="VAB18032_15610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15610"/>
    <dbReference type="eggNOG" id="COG3727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3141983_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="49" mass="5745" checksum="284E4B382A5BD94E" modified="2011-06-28" version="1">MDRDKRTRQALEDAGWLLIVVWEHEDVNLAVHRIVKSVRTRRGFTALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5M4</accession>
    <name>F4F5M4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44237">
        <property type="protein sequence ID" value="AEB44237"/>
        <property type="gene ID" value="VAB18032_15625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15625"/>
    <dbReference type="HOGENOM" id="CLU_3278339_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="41" mass="4457" checksum="FFA3A1825EAE2672" modified="2011-06-28" version="1">MHGQSTAEVPEIIGRNRYRASRALSSSTASRSPPAVTLWNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5R8</accession>
    <name>F4F5R8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732945.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15855"/>
    <dbReference type="EnsemblBacteria" id="AEB44281">
        <property type="protein sequence ID" value="AEB44281"/>
        <property type="gene ID" value="VAB18032_15855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15855"/>
    <dbReference type="eggNOG" id="ENOG50343I2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1767284_0_0_11"/>
    <dbReference type="OMA" id="MTEGRAT"/>
    <dbReference type="OrthoDB" id="2064609at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="147" mass="16142" checksum="851EB18678456A44" modified="2011-06-28" version="1">MTGPRQAQWFHFGPWVFSIDAAQALIAAAPRDTQPLDVPTWARAYGLIRLDDPHQRAVSLIGPTSTALDRAHASTTDLTTPLIVAQLDISGYPPAPLLIDGTHRLYRAWREHLPHLPAYLLTVEETRQVQDNVLLGPGRAAITGPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Y0</accession>
    <name>F4F5Y0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22195"/>
    <dbReference type="EnsemblBacteria" id="AEB45539">
        <property type="protein sequence ID" value="AEB45539"/>
        <property type="gene ID" value="VAB18032_22195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22195"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_13_11"/>
    <dbReference type="OMA" id="AAYRHDC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="609"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="937" mass="100483" checksum="A30857BC778D1FDC" modified="2011-06-28" version="1">MVAAAWAKVRSVLTGDPELPPGPWRGLLGTDTGEATPTGEPPTAVCLEHPADLLRGVDASRTGEYLDGVLRAIAADLDAPHEKHSLLTGKDVWRQLHVFHGELRELPDRRAHELIGEQARRTPHAVAAVRGELRWTYAELDQRANAVANRLLAAGARPGDVVAVLSDRTLPWVAAILGILKAGLVYLPVDPAYPHSRIAGILRRSGTKLLLAEVPTEPIADVPVLPLEAAGPTIDPQVSVPADAPAYIYFTSGSTGEPKGAVCAHAGMLNHLSAKIDDLGLTEQDAVCQNAPQCFDISLWQVLAPLLVGGRTVLVPPQVILDVEAFVSTLDRERITVLQVVPSYLEVLLGHLDLSPHQRPTPRIVCVTGEAISRSLVARWFGCFPDVPLVNAYGATEVSDDTTHEIMRALPATELVPVGRPVQNVSVYILDSQLALVPFGAPGQIAFAGICVGPGYINDPDKTAAAFVPDPFRPDQRMYLTGDYGRWLPNGHLEFLGRRDEQVKISGMRVEVGEVENTLLRVPGVRSACLVVVPIGTSKRLAAFFTADEPVPDLKRRLADLLPAHMVPSTVHQLDALPLTENGKVDKAALVAAALRAGAQATVSQEREQATNPLERRLAAAWAEVLNRPLDDIYRTDNFFALGGDSLSAVRLVVKLKHLITLTTLTSNPVLADLAEAASRTGQAQLLQALATPQEPVATVVTVPDAAGTALNFQPLAAGLAATNCALLATELPGHDLARPEEPLADVAQVATRLADEIAARVDTPLILWGQGSGAAVAVQCARLLHDRGRPAAQLVLAAATADPHQLAADLAEVQAMGEGEIRRHMAAQATYTELDELKSEREALIERAYRHDTLGAARFLQHARDGWPALTVPTWVVVGDDDMRLATEPRPELAWRHFAPTAEQVVLPGAGRHFLRTHADEVVTLLRSIVTTRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Y6</accession>
    <name>F4F5Y6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734198.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22225"/>
    <dbReference type="EnsemblBacteria" id="AEB45545">
        <property type="protein sequence ID" value="AEB45545"/>
        <property type="gene ID" value="VAB18032_22225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22225"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015707_0_0_11"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="799" mass="84814" checksum="9B0FFFEFACF0D3AF" modified="2011-06-28" version="1">MTAYLTLDDLAATARSKLPVEVWDFVEGGAGRERTLAANRDAFARIRLRPRVLTGVTEVDPRVNVLGGVWAVPVGIAPLAYHTLVHPDGELATARAAGACGVPLVVSTMAGRAFDEIRAETTAPLWLQLYPLRDPAATAHLVRTAERAGFDALVLTVDAPRLGRRLRDLRNGFRLPDGVVPVNLPASWRTGAARPAGHAESHFATGLTWDAVARLCASTTLPVIVKGVLTAEDARLAVAAGVAGVVVSNHGGRQLDGAPASLDALPEVARAVDGAAVVLLDGGVRTGADVLGALALGATAVLVGRPVLHGLAVDGEQGVGEVLRILTEEFVESMFLTGLATVAAIGPATVTAPVTAPATGPPERTGGALPTGLHLTDLHASLRHPVLRTMTFLNEIVARYPDAVSFAPGRPFEDGYDLAELSGHLGAYLEHRQAGGQTGNALTRELFQYGPTAGTIRDIVARTVAQDEGIHVAPEAYVITVGAQEGLLITVRAFCAGPDDVLLVPDPCYTGVTGVASLLGVRVEAVPETTDGPDLAYLDRLLARLHAEKRRARLLYLVPDAANPSGTTMSRHAREQLLRVLRPYGTVVLEDTPYRLLGPADRPPTLKALDRHGQVVHVGSFAKSAFPGARVGYVIADQTVYRPDGTGLLADELSKIKSMVTVNTSPVSQALIGGLLLRAGHRLGEATAPAARRYSAMMRLLRAELDRRFPQPVRDRLGISWNDPDSGFFLSLTVPFVAGDEQLDDCARRYGVLWTPMSYFHVHPDAGQHAVRLSVSYLTEQEIVDGVGRLARFITETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F661</accession>
    <name>F4F661_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735462.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28711"/>
    <dbReference type="EnsemblBacteria" id="AEB46813">
        <property type="protein sequence ID" value="AEB46813"/>
        <property type="gene ID" value="VAB18032_28711"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28711"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129852_1_0_11"/>
    <dbReference type="OMA" id="LSVQYPF"/>
    <dbReference type="OrthoDB" id="1967752at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033437">
        <property type="entry name" value="DUF5130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17174">
        <property type="entry name" value="DUF5130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="137" mass="14914" checksum="F8D8F0F6A6B772D1" modified="2011-06-28" version="1">MTVGEMQPETGTEPRPDVLDGPFSTRQLLRIDEALRLADRTTGLVFSVFVGGLDEPIREHAERLHRQLANPDRSVLIAVSPNQRQLEIVTGRYARKRVPDTYAKIAALSMVASFGGGDLAGGIIQGLDQLSRYAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F667</accession>
    <name>F4F667_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-oxalocrotonate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735468.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28741"/>
    <dbReference type="EnsemblBacteria" id="AEB46819">
        <property type="protein sequence ID" value="AEB46819"/>
        <property type="gene ID" value="VAB18032_28741"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28741"/>
    <dbReference type="eggNOG" id="COG3971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060136_4_0_11"/>
    <dbReference type="OMA" id="YVHPRVE"/>
    <dbReference type="OrthoDB" id="1314120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="26878" checksum="6CFDF07178CDCA52" modified="2011-06-28" version="1">MSGLDPAGIAEQLDKAATTATAIPQLAAEVGLDVDAAYGVQTALVQRRLDRGERLVGLKMGLTSKAKMAQVGVDEVIWGRLTDAMWVPDGGSVDVSTYIHPRVEPEVAFLLDRLPEPGEPLGAFTDAVRAVAPAIELIDSRYANFTFSLPDVIADNTSAAAFVVGPWSPVPDGLDNLGVLLEIDGRVTQVGSTAAILGDPRRALDEGVRLAGRHGVRLREGWVFLAGAATAAVPLRPGAQVRAVVEKLGTATLKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6B7</accession>
    <name>F4F6B7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_09725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731734.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09725"/>
    <dbReference type="EnsemblBacteria" id="AEB43063">
        <property type="protein sequence ID" value="AEB43063"/>
        <property type="gene ID" value="VAB18032_09725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09725"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="OMA" id="NIHGEGF"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="25128" checksum="49049FD9C1F137C8" modified="2011-06-28" version="1">MRARVLVVDDDPALAEMLGIVLRSEGFMPSFVADGERALAAFRDNRPDIVLLDLMLPGMSGIDVARAIRAESGVPIVMLTAKSDTVDVVLGLESGADDYVVKPFKPKELVARMRARLRRGEDAAPELLTIGPPGNQIAIDVPAHTVSRNGEEVKLTPLEFDLLVALARKPRQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRAKIEPDPERPEIILTVRGVGYKAGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6C0</accession>
    <name>F4F6C0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731737.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09740"/>
    <dbReference type="EnsemblBacteria" id="AEB43066">
        <property type="protein sequence ID" value="AEB43066"/>
        <property type="gene ID" value="VAB18032_09740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09740"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_3_0_11"/>
    <dbReference type="OMA" id="PATRWCP"/>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="232" mass="24289" checksum="6AC9F48524B75BCD" modified="2011-06-28" version="1">MLRGLWADLADLALPIECAGCRQRRPGLRHGVCPHCVTALHALRPVQVRPVPAPVGLPPCHALGSYGGPLRETLLAYKEHGRHGLARPLGALLAEVVADAVGSARPLVLVPVPDTPAAARARFGDHLGRLARHCARRLDAAGWPVRVDRPVRALPRPDSVTLDSAGRAATALAAFRVRPDAGPVPPGATVVLLDDIVTTGSTLAAISQLLAVQGMSPSVAAVLAATEKRHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6D2</accession>
    <name>F4F6D2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsE</name>
        <name evidence="8" type="ordered locus">VAB18032_09800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731749.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09800"/>
    <dbReference type="EnsemblBacteria" id="AEB43078">
        <property type="protein sequence ID" value="AEB43078"/>
        <property type="gene ID" value="VAB18032_09800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09800"/>
    <dbReference type="eggNOG" id="COG2884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="LPMYQRA"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="25317" checksum="8864B547996B68F9" modified="2011-06-28" version="1">MIQLEQVTKTYPKASRPSLDNVSVSIDKGEFVFFIGPSGSGKSTIIKMLLHEVTPNKGRVVVNGKDVTSMRSWKRPHFRRSIGCVFQDFRLLPNRTAYENVAFALEVIGKTKAVARRVVPEVLELVGLGGKEHRYPHELSGGEQQRVAVARAFVNRPLILLADEPTGNLDPDTSIEIMRLLDRINRTGTTVVMVTHDSNIVNQMRRRVIEIESGRIVRDQARGVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6L4</accession>
    <name>F4F6L4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733002.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16180"/>
    <dbReference type="EnsemblBacteria" id="AEB44342">
        <property type="protein sequence ID" value="AEB44342"/>
        <property type="gene ID" value="VAB18032_16180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16180"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="435" mass="46951" checksum="A1D433E5FDDF52A6" modified="2011-06-28" version="1">MLGGVVPGTSLKDRYRLARSPLAHKGMSEVWPAHDALLDRPVIVKFVAVTELDLVRRFRREALLTARLDHPGVPAVYDLGEHAGHPYLVLQQINGIALSDLVAEHGPLPIGWVAAIGAQISSVLLAAQRLGLVHRDIKPSNAMLEPSGAVKVLDFGLAVTPDDDRYSRITQSGQALGTFGYMAPEQILGQRIDHRADLYGLGATLFDLLTGTAPFDGLTTMTTVRQQMGATPPRPATLRPETPSVLDDLVHALLASAPDSRPDSAADVYRVLAPLAENLPPIPGVLDDSVTAVQAYAAIVGRIPPQPGPTIAPAAAPSALDLGQAVRQAEQMQAAGEFRAAARQWRRLAEHRARQHGDEDPQVFDLRLRAARTHVALGEHPRALRLLTALLQDRERVDGPEHPAVRELREEISRLSTEPASAPALPQQFVPDADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F717</accession>
    <name>F4F717_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29051"/>
    <dbReference type="EnsemblBacteria" id="AEB46881">
        <property type="protein sequence ID" value="AEB46881"/>
        <property type="gene ID" value="VAB18032_29051"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29051"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_2_0_11"/>
    <dbReference type="OMA" id="YERQSHA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="244"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="42809" checksum="CDA45A3EAF2F3D3E" modified="2011-06-28" version="1">MDVSQKPTRDELRRRAADLVPVLRANALASERNRGLTDETVQAMTEAGIFRLRIPERFGGYACDTRTLVDVGIELGRGDGSAAFNTAAWWIMSWNVGMFPDEVQEEVFTSPDVRVCGTLAPTAMAVPKDGGIVVSGQWNFNSGAAHSQWKLLSAILPDGEGGAEPVLAIAPMSAFEVEDDWEVSGLRGTGSVTLRTQDLFIPTAKYIKISALMQQQYASVLNRDLPIYRGPMVGAVSAATTGKIVGLAQAAREAFFERVPGRPITNTGYASQIEAPVTHLQVADADLKIDEAEYHARRLAEMVDGKGLRAEPWSLKERAYARMAVGRVCQLGMDAVNIYAMASGASSIYSTIPIQRIQRDMQTINLHALNLPSTNLELYGRILCGQEPNTFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F726</accession>
    <name>F4F726_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735539.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29096"/>
    <dbReference type="EnsemblBacteria" id="AEB46890">
        <property type="protein sequence ID" value="AEB46890"/>
        <property type="gene ID" value="VAB18032_29096"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29096"/>
    <dbReference type="eggNOG" id="ENOG5033W0I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058028_0_0_11"/>
    <dbReference type="OMA" id="IRWTQTR"/>
    <dbReference type="OrthoDB" id="1828338at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="42624" checksum="D084F15B624F21B4" modified="2011-06-28" version="1">MSADPEAIRLTPAVIPVTGGYDGRAATTAVKVGVGQAAAAVARVSDRGARIVAVTIALVWHLAIALPAVLGARTQLAVPQVVLGAWLLVAAVGLLAGVRLLRDTPLPTPPLVGLLLAVDVAVFATVGRAQLFSPANWVWGTLAWFFLVVLWGRPVRWLLALLAAHAATALTAVVLYAATGAADLARAAMALYGTSSLPVAVFAGALMLGLLLRDRAASAAASNVMLAEREAAERARGERRDRLAVVSDAATEVLTELAQGRADPSDPDVQRRCVRAAARLRRLIAESDDVPHPLLHELRAAADLAERDGLSIDLVTIGTPPPLSVQVRRRLVEPLTATLADERDWARLTIVANPDEVVVSLVVPDRAGPDATGGQPEQGDGQVEYLYERDGEIRWTQTRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F749</accession>
    <name>F4F749_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, rpir family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29211"/>
    <dbReference type="EnsemblBacteria" id="AEB46913">
        <property type="protein sequence ID" value="AEB46913"/>
        <property type="gene ID" value="VAB18032_29211"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29211"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_0_1_11"/>
    <dbReference type="OMA" id="QDLEHAP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="124"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="30242" checksum="71AA0DAB817FA569" modified="2011-06-28" version="1">MIVHIGGLLPSLSPAEQRVARLVVADPAEAARRTITDLATAAETSEATVIRFCRSVGVDGYPQLRIRLAAEAARRIEPSDGRIAGGDIPPGADLARIIATIGFNDARAVEQTAEQLDPAVCEQVVEAIVGAGRIVIFGVGASGFVALDLQQKLHRIGRAAFCFPDVHTALTSAALLARGDVAVGVSHTGATSDVIEVLAQAGSRAATTVALTNFPRSPLATLADHVLTTAARETTYRSGAMASRIAQLTVVDCLYVGVAARNRPRARKALEAGAEAVRSRRVESGRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F758</accession>
    <name>F4F758_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 1 extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735570.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29256"/>
    <dbReference type="EnsemblBacteria" id="AEB46922">
        <property type="protein sequence ID" value="AEB46922"/>
        <property type="gene ID" value="VAB18032_29256"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29256"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027068_0_0_11"/>
    <dbReference type="OMA" id="KPWCAGI"/>
    <dbReference type="OrthoDB" id="480174at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312741" evidence="1">
        <location>
            <begin position="33"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="450" mass="48658" checksum="F64337D0AFE1CBEA" modified="2011-06-28" version="1">MAVFARPRQALAIAGVLGLTLGVTACGTGSSDNSGGNNNADSAECAPYEKYQGHSGKKVNIYSSIRDIEADRLDQSWKEFEDCTGIDISHEGSGDFEAQLPVRADGGNAPDIAFIPQPGLLQRFAERGQIKAASADTKAMAEQNYPADWLKYSTVGGTFYGAPLGSNVKSFVWYSPKMFQEKGWTVPTTWEEMIKLSDTIADSGTKPWCAGIESGDATGWPATDWIEDVMLRTQTPEVYDQWTTHEIPFNDPRVVEAVDRAGTILKNEKYVNGGFGGVRSIATTAFQEGGIPITAGKCALHRQASFYANQWPENTKVAEDGDVFAFYFPAIDPSRGKPVLGGGEFVVAFADRPEVQAVQTYLASGEHANSRAKIGDWVSANNKLDLANVSNPIDKLSVEILQDDSSVFRFDGSDLMPAAVGAGTFWKGMVDWINGKDTASVLQGIESSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F763</accession>
    <name>F4F763_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_29281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735575.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29281"/>
    <dbReference type="EnsemblBacteria" id="AEB46927">
        <property type="protein sequence ID" value="AEB46927"/>
        <property type="gene ID" value="VAB18032_29281"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29281"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_11"/>
    <dbReference type="OMA" id="NSPNWFA"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="474" mass="49504" checksum="943DD41D4408BB4D" modified="2011-06-28" version="1">MTSTTGRAPRVWGGNAAHRFYSVVVFVLLASLDNVAIGLVPPLYGAIAESFAVPQRLLGLVTAVSFLVSAVAAVGWAYFGDRTNRKPLLMIGTLIWAVGTGGSGLAGSYPTFLAAQLLAAVGLGAVGSVGFSVVTDLISPRRRGLVMSFWGLSQGAGTLAGTLVGGLLGAADWRRPFLLLTVVGLVATVAYLLTYDIRRGQSEPELADALAGGADYDYRISRRDLPVILHRRTNRWLILQGLTAQAAFGSLVWLPVLFAERAQDQGYSMATAIVVGSVFATLFQLGGVLSIVGGLVGDALQRRTPSGRAMVAAVGVLAAVPFYLVLFFVPIRIDVPDGAGTGTVVRAVLASVVTEPTVGLSLLTALLALALTSANSPNWFALIADANPPEHRGTVYSLGNLVNGVGRAAGNGLVGVAFHALRAAFPPPLNYAVGLAAFQLFFIPTGIMYWLAARTSPKDIADVADLLHARAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F768</accession>
    <name>F4F768_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellulose-binding family II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_10040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731797.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10040"/>
    <dbReference type="EnsemblBacteria" id="AEB43126">
        <property type="protein sequence ID" value="AEB43126"/>
        <property type="gene ID" value="VAB18032_10040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10040"/>
    <dbReference type="eggNOG" id="COG3934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_838910_0_0_11"/>
    <dbReference type="OMA" id="QNWTAID"/>
    <dbReference type="OrthoDB" id="989347at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001956">
        <property type="entry name" value="CBM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036966">
        <property type="entry name" value="CBM3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00942">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01067">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51172">
        <property type="entry name" value="CBM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313640" evidence="4">
        <location>
            <begin position="27"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CBM3" evidence="6">
        <location>
            <begin position="126"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="32773" checksum="EEAC3140BCC373E1" modified="2011-06-28" version="1">MRARRFTLVAVLAATLGLSGTAIAYAADDPVILTTPGAPVVVTNEPHLLTLSWAPSTWIGEPGATPIRHEVRAWLGPNTYRSLGTTTGTELTLTDLAPGTEYRLTVWASTNGGYSLDSPQIPVRTAYGKARVSYHNMDWSPTDNQIQHALQIVNTGTTPLDLTEVRVRYHVTFEGGNTSLVTNCDWAAIGCANVQRHVQFFPLPQPPPPPTRTPTPTPTPTRTVLPPHGTSIPGWIELTFASGTLAPGASTGPIQLRHHRQNWTAIDERDDPSWQQSTGGWTENSRITLDVNGTREYGDTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7F1</accession>
    <name>F4F7F1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">abyC</name>
        <name evidence="4" type="ordered locus">VAB18032_16420</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733050.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16420"/>
    <dbReference type="EnsemblBacteria" id="AEB44390">
        <property type="protein sequence ID" value="AEB44390"/>
        <property type="gene ID" value="VAB18032_16420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16420"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_27_0_11"/>
    <dbReference type="OMA" id="CHQFAPQ"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEK75505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="230" mass="24781" checksum="012774D5E4F15804" modified="2011-06-28" version="1">MTERDTRNAPRGRLDKRQAIIAAALRVFAREGYGQASLDTIAAEAGVAKPTIYNHLGGKENLFRHVLAEIAARSNAKTLAALQTFPTDPQELRDHLNTVGLRLAECFVDEQSSALRRLLHAEIARFPDLFDVVLDSGPNQATEALAGRLARLANAGYLTIEDPIRAARQFVALLTDELPAMTALGTRPINPDDLERAVTAGVDTFLRAFATPTDAPADPPAREAVGPLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7K7</accession>
    <name>F4F7K7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733105.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16710"/>
    <dbReference type="EnsemblBacteria" id="AEB44446">
        <property type="protein sequence ID" value="AEB44446"/>
        <property type="gene ID" value="VAB18032_16710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16710"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043007_1_0_11"/>
    <dbReference type="OMA" id="VFQNNRV"/>
    <dbReference type="OrthoDB" id="746749at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312756" evidence="1">
        <location>
            <begin position="31"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="22450" checksum="D3547C267E0A6517" modified="2011-06-28" version="1">MNTMRTRSRFLTGLTLTAALLAGTAIPAVAAPIVLSSGHVDVIDVDYAGGALTVSLLDDTVSPSVERNPADVVLRVPNTAKVTVPSGSAWSFLGVGGQAWVLPQASSSGLLWAGWNTAEVPHGVFQNNRVTFKLTNVTGPAGFSVYTVSGGTPTVLFDSGNGLPDSLNVNYNTHAHVNWGFDAAGTYAVTFEVTGKLASNGTAISSGAKTWTFEVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7R3</accession>
    <name>F4F7R3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bicupin, oxalate decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_23000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734352.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23000"/>
    <dbReference type="EnsemblBacteria" id="AEB45700">
        <property type="protein sequence ID" value="AEB45700"/>
        <property type="gene ID" value="VAB18032_23000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23000"/>
    <dbReference type="eggNOG" id="COG2140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030515_2_0_11"/>
    <dbReference type="OMA" id="HPNNDEW"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="228"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="381" mass="42797" checksum="291EB5D8D89A8A58" modified="2011-06-28" version="1">MRKSDEFGMHSNGNGSLVGTLPRNPAIDDTHPDLVTPPSTDDGLLPNMVFPFSLAHTRRESGGWTREVTDRLLPIAHDLAIIDMKLDPGAYRELHWHIQSEWSIILKGSGRIGAVDQEGRNFLEDVKEGDLWYFPAGIPHYIQAFEEGMEFLLVFDDGCYSEDATFQLTDFLAHVPRSVIAKNFGWTEEQMRNLPEREKYMFHGQVPPPLAEQRVFSPTGDVPRTFKHAFLAQTPERFEGGSVRIADSTNFAAATTTTVAMVELEPGAMRELHWHPNGAEMQYVISGQGRMGVFSGGSTARTFNLQRGDVGYVPISLGHYIENLGDEPFVYLELFRTAKFEDMSLAQWLANVPPQVVADTLNMQRQVIEVLPKVKNAVQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F852</accession>
    <name>F4F852_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731884.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10475"/>
    <dbReference type="EnsemblBacteria" id="AEB43213">
        <property type="protein sequence ID" value="AEB43213"/>
        <property type="gene ID" value="VAB18032_10475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10475"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_971968_0_0_11"/>
    <dbReference type="OMA" id="YARRIGW"/>
    <dbReference type="OrthoDB" id="1619221at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="277" mass="30785" checksum="FEA8BF9F3F46DC95" modified="2011-06-28" version="1">MDAVKLRRAIARTRLAPVAAFPKRLVTVARHDAKVLRTSARWLLASREHHNYTYELTKLSRSHLAWFVSVVCDLPVAHVRGYLDEIESDDALRQHIASTIGSAARRGLADKQVRYARRIGWYAIVRARRPAHIVETGVDKGLGSCVLAAALLRNAAEGHPGRVSSIDINPEAGYLARVAPWSEVIDLVIGDSVESISALDQPVDLFLHDSDHSRAYEKREFEAVEPKLAPGAMLLTDNVTHTNVLARHAERTGRKFLAYRETPANHWYPGDGIGVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8U9</accession>
    <name>F4F8U9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735677.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29791"/>
    <dbReference type="EnsemblBacteria" id="AEB47029">
        <property type="protein sequence ID" value="AEB47029"/>
        <property type="gene ID" value="VAB18032_29791"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29791"/>
    <dbReference type="eggNOG" id="ENOG5033GN1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140382_0_0_11"/>
    <dbReference type="OMA" id="DWHFIGM"/>
    <dbReference type="OrthoDB" id="2063146at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="128" mass="13084" checksum="DD12D45125AE23E0" modified="2011-06-28" version="1">MNAAGSPVDGVVAVAAIVLSLLVAVWALIATLRHRAPDRIQLIGLGVLELALLALAVLAGVALAGGDQPGEPGAFFGYLVTLVCLPPLAGVLARMEPTRWGSAIVCAICLVTPVVVVRLQQTWEVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F922</accession>
    <name>F4F922_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_04620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730724.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04620"/>
    <dbReference type="EnsemblBacteria" id="AEB42050">
        <property type="protein sequence ID" value="AEB42050"/>
        <property type="gene ID" value="VAB18032_04620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04620"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_0_1_11"/>
    <dbReference type="OMA" id="HHIEVHG"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cation_ATPase_N" evidence="10">
        <location>
            <begin position="620"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1464"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB42050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1485" mass="153091" checksum="CB4C0691A46EF1FB" modified="2011-06-28" version="1">MTSLGGLVRRLRPPVDVPLVNDVARDAGAAVTRLARTIGLSSRRVWSRPGRHHIEVHGVCQDGGDVLARQVETALQRMPGVQWARVNAPSGRVVVAVDTPGPKVRELIATIARTERTCPHEPDPDIPPPQPPEEGPRTARTLGALASDALGLTISAATRILPITPIPAEVAGLLGAVDLHPRLHALAGLGIRSDPRADLLFPLAEAVVQGLAGGWTGIVLDGAQRIVQWGEGLAQLRAWEKAEPRLTGEPERAVARTPDGERPCPKPDSTVDRYKTRMLGGGVAAFAAAAPVIGPKRAAALGLSALPKAPGSGREGYGAQLGWILAKRGVIAMDRSVLRELDRIDTLVLDTRVLGTDRGVLADLAPLPGADTSQVAARAFALFDPDAPGELRRLDGWQLGPLDRLDVRDPGDTDDSRRLRERGGNLLGLAQGDTLAAVLRVDPEPAPGVDSLPAVARQAGLRIIVAGGDAQRHAFADALLPGEDQLAASIRVLQREGAMVMLVSGDRAALAAADCGLGVADPEALPPWGAHLLIGTDLRIAALIIEAAGVARRMTVQNMRVGLAGTGLGALSALTADRAVLPVRTLAAVNGAAALAFGHGVWRATRLSEHAETPAPAITAWHLMPVPTVLQQLGSSPDGLTDTEAERRQASGPGEAGGRGGLLRAFADELVNPLTPILVTGAALSASFGSLVDAALVGGVVGGSALVGAVHQRNTEKALSQLLSRSAVTARVRRSGTERMVPADDLVPGDVIVLESGDAVPADCRVLDSVGLEADESSLTGESLPVSKNDQPVVAAAVAERRSMLYEGTTIAAGQGTAVVVATGADTEAGRSLALARQAPPASGVEARLGNLTRAAIPLAAGSAVAVVGAGLLRGVPLGQTAATAANLAVASVPEGLPFLVSAAQLAAARRLAGHGALVRNPRTIEALGRVDVLCFDKTGTLTEGHLLLAGVGDADGYASTEQLDDRLRQTLAAALRATPTADDPEELSMQTDRAVLRGARAAGVHEQDAAPGWRAAGGLPFEPSRGYHASVGETQGRMLLSVKGAPEKVLPRCAARRTGGHDEPLDDAGRADLHRQLGERAGAGHRVLAIAERFVDDPDITDDDVADLTFTGFLTIADGVRDSAAPAVHRIRQAGVHTIMITGDHPATAEAIAATISHGEAQRVVTATELDELDDDALADRLAATDVVARCTPTHKVRIIQALQKRGRTVAMTGDGANDAPAIRLADVGIALGQRGTPAARAAADLVVTDDRLETIIATLVEGRAMWSSVRHALSILVGGNLGEIAFSVLTAAATGQAALNGRQLLLVNLLTDMAPAMAIAVRPPAADHADGMLREGPDRSLGQTMTKEIGLRAAATTLGATAGWTLARYTGRRRRAGTVALVSLVGTQLGQTVLAGGTSPTVLASTAVSFGVLAAVVQTPGVSQFFGCTPLGPVGWTIATGSALGATLANGAMTRLVARLPPLDRPNADHTGHGDHQSPEPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA80</accession>
    <name>F4FA80_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaK</name>
        <name evidence="10" type="ordered locus">VAB18032_05075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730815.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05075"/>
    <dbReference type="EnsemblBacteria" id="AEB42141">
        <property type="protein sequence ID" value="AEB42141"/>
        <property type="gene ID" value="VAB18032_05075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05075"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_11"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="581"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="627" mass="66659" checksum="8C20A5D9EFCCD6E5" modified="2011-06-28" version="1">MARAVGIDLGTTNSCVSVLEGGEPTVIANAEGSRTTPSIVAFARNGEVLVGEVAKRQAVTNPDRTIRSVKREIGTNWSVDIDGKKYTPQEISARTLMKLKRDAEAYLGEQITDAVITVPAYFNDGQRQATKEAGEIAGFNVLRIVNEPTAAALAYGLDKGSKEQTVLVFDLGGGTFDVSLLELAEGVIEVKSTSGDNLLGGDDWDQRIMDHLVKTFRGEHGIDLSQDKMAMQRLKEAAEKAKIELSAATTTNINLPYITAGAAGPLHLDVTLSRAEFQRMTQDLLDRCKVPFEQAVKDAGIKVSDVDHVILVGGSTRMPAVTDLVKQLTGRDPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGIFTKLIERNTTIPTKRSEVFTTADDNQPSVLIQVFQGERDIAAYNKKLGTFELTGLPPAPRGVPQIEVTFDIDANGIVNVHAKDLGTGKEQKMTITGGSSLPKDDIERMRRDAEEHAEEDKRRRDEAEARNVAEALQWQTEKFLAENGDKLPAENREKLNEALGELRGALGGSDIDKIKSAHERLAQVSQEAGSLLYAQQGEQAEAGGAAGGAGAGAGGAAGAAGAGQAGGRPGADDVVDAEIVDEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBC1</accession>
    <name>F4FBC1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein MerR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730890.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05455"/>
    <dbReference type="EnsemblBacteria" id="AEB42217">
        <property type="protein sequence ID" value="AEB42217"/>
        <property type="gene ID" value="VAB18032_05455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05455"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045945_3_2_11"/>
    <dbReference type="OMA" id="GDVRQEC"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="191"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="316" mass="32848" checksum="9352C27311A66290" modified="2011-06-28" version="1">MADEALSAGAVARRLGVAVTTLRTWHQRYGLGPSQHVPGHHRRYTPADLARLEIMRRLTAEGVNPAEAARWARQAPDPVSARTPRPVRSTPARAGGGATIPVRRAGPVARGLARAAMRLDAEVISETIARSIATDGVVDTWDRLLRPVLVGIGERHAATAALIEVEHLVSRCVSAAFAAVVAGCPAPAGQPPRILLSCADEEQHSLPLEALAAALAEVGVNHRMLGARVPVNALLDAIDRTGPAAVVIWSHTRVTGDPAQLSALLGAPRRPLLVIAAGPGWPADSLPAGVVHPGGLAEAVSLAVAVRDSLDRSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBG1</accession>
    <name>F4FBG1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05655"/>
    <dbReference type="EnsemblBacteria" id="AEB42257">
        <property type="protein sequence ID" value="AEB42257"/>
        <property type="gene ID" value="VAB18032_05655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05655"/>
    <dbReference type="eggNOG" id="ENOG5034B08">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331466_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="206" mass="20597" checksum="277087FA6383BFB6" modified="2011-06-28" version="1">MFLSLAAQVVGAESSVIGWVAAALPALGFLAMVKIALGRADPAPLHRTVPSAPSSRSGRVGSRPVSGTGARVPDSAGTVRGPAAAVHAGPTAVRDIAPAATATAGRSTVPDSRNSHAGVRDGGPEIAALVPVARTAAGALAAQGTPLSRQALARQLRADGHQLSNATTSALVRVLRAETTPADQLQQVPRDRTSPGFCRATGADST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBH3</accession>
    <name>F4FBH3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730942.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05715"/>
    <dbReference type="EnsemblBacteria" id="AEB42269">
        <property type="protein sequence ID" value="AEB42269"/>
        <property type="gene ID" value="VAB18032_05715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05715"/>
    <dbReference type="eggNOG" id="COG5500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111152_0_2_11"/>
    <dbReference type="OMA" id="AMQRINV"/>
    <dbReference type="OrthoDB" id="2075110at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="161" mass="16986" checksum="029F8CCFB5C0CB20" modified="2011-06-28" version="1">MPESIRIVVLAGATFSTGLVAGLFFAYACSVMPGLGATDDRTLIGAMQSINRKILNGWFLSVFLGGPLLVMVAVLGHLGVDGAVLGWLVVALICHSITFAVTMRSNVPLNDQLDAARSVDGTTDLAAIRRRFEGPWVRWNLVRAVSSGAAFACVIGALLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBP1</accession>
    <name>F4FBP1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nusA</name>
        <name evidence="10" type="ordered locus">VAB18032_11945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732172.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11945"/>
    <dbReference type="EnsemblBacteria" id="AEB43503">
        <property type="protein sequence ID" value="AEB43503"/>
        <property type="gene ID" value="VAB18032_11945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11945"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_11"/>
    <dbReference type="OMA" id="MDIDMSA"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="347" mass="37434" checksum="AFE2F5E99166F867" modified="2011-06-28" version="1">MNIDLAALRALEREREIPFDTILAAIETALLTAYRHTEGAQSHARVEIDRKSGAALVYAQEMDPEGGVVREWDDTPHDFGRIAAMTAKQVILQRLREATDEVHFGEYVGRDGDLVTGVVQAHEARAEKGIVTVDLGKLEGVLPQSEQVPGERYTHGERIRCVVVHVAKGMRGPQITLSRTHPNLVKKLFALEVPEIADGTVEISAIAREAGHRTKIAVRSTTPGVNAKGACIGPMGQRVRAVMSELHGEKIDIIDWSDDPATFVGNALSPAKALRVEVVDLANRAARVTVPDFQLSLAIGREGQNARLAARLTGWRIDIRSDAEQAGAAGRPGVDQVREPGGAVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBW7</accession>
    <name>F4FBW7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose transporter permease RbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18325"/>
    <dbReference type="EnsemblBacteria" id="AEB44767">
        <property type="protein sequence ID" value="AEB44767"/>
        <property type="gene ID" value="VAB18032_18325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18325"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_0_2_11"/>
    <dbReference type="OMA" id="LPVSIWI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="33735" checksum="545DF87EA0C92DC8" modified="2011-06-28" version="1">MTAQTVSRRLAPLRRGNAGGILPILAVLVVLLALVAARQPDFLSPPSLMSFLGRSAPIILLAAGQYFVIVSGEFDLSVGSLVTAQVVVAARLIDSDPSRTWPVVLVLLAGGALVGLVNGLITTRLRVPSFVTTLGMFLILVGAVYLWSDGAPKGGLTDQFRQLGRRAVEDVPVLGRLPYALLVLLVLAVAAVLLMRSDFGRTLVAVGDNPRTAQLSGVRVWRTRTIAFVLSGLAAAVAAILIGGYGGVSFQAGAGLEFGAITAVVLGGVALGGGRGSVVGAMLGALTLELLFALMNFYGVSGALRPSVQGAIILLAVAVSARRFSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC98</accession>
    <name>F4FC98_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="13" type="ordered locus">VAB18032_00965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735921.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00965"/>
    <dbReference type="EnsemblBacteria" id="AEB47277">
        <property type="protein sequence ID" value="AEB47277"/>
        <property type="gene ID" value="VAB18032_00965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00965"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_4_11"/>
    <dbReference type="OMA" id="ITAFQFR"/>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="thiE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="9">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="9">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
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        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="20771" checksum="CF1A1F916FA1284C" modified="2011-06-28" version="1">MPSLGRLHLITDTRPGRDALAVLAAALPVAHTELVVQVRVEDTTTDREAYELTRQVLVLCRPYGVTCLVNDRLHVALAAGASGGHVGADDLPVATARRVLGPDAVLGATAREPVSAAEAVAAGASYLGVGPCHATTTKDGLPPAIGVAGVRAVVEAVTVPVIAIGGVTAEDVPVLRSAGVYGVAVVGALSGAADPAHAAAEFVDALAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCE5</accession>
    <name>F4FCE5_MICM1</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="263358.VAB18032_05730"/>
    <dbReference type="EnsemblBacteria" id="AEB42272">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="24998" checksum="D534F56BA591249A" modified="2011-06-28" version="1">MLTVAEMTLRELARRRGVLLLLLLMPFVFWLIRRDSYVGQSIRALLLGISWAVSTAALFATSAARELEPRLRLAGYRPHHLYVGRMLGLWLLGLAVSVPFFLLTVVDANNLRYAGIAMAMLCCVAVAAPFGMLIGALLPRELEGTLLLLTVVAMQMLLDPASPGSKLTPFWSSREIATWAVDHADGGYLTRGLLHAVLVTALLIVTVAGVFGVRLRRRRHLHHVPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCF4</accession>
    <name>F4FCF4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="12" type="ordered locus">VAB18032_05775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05775"/>
    <dbReference type="EnsemblBacteria" id="AEB42281">
        <property type="protein sequence ID" value="AEB42281"/>
        <property type="gene ID" value="VAB18032_05775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05775"/>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095787_1_0_11"/>
    <dbReference type="OMA" id="FKNFIMK"/>
    <dbReference type="OrthoDB" id="1863650at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB42281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="157" mass="16925" checksum="1935219A0BC03E5B" modified="2011-06-28" version="1">MLKGFKDFIMRGNVVDLAVGVVIGAAFTGVVTQLTKSFLDPLIRVFVVLVTGSNKGLEGTAPTIQGIPFDWVAFVNALITFLLTAAALYFLVVFPMNKLAERRKRGEEPPPAAPSEEVKLLTEIRDALVAAGRTTPTQQRSALDDVLGSREEPPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCG1</accession>
    <name>F4FCG1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05810"/>
    <dbReference type="EnsemblBacteria" id="AEB42288">
        <property type="protein sequence ID" value="AEB42288"/>
        <property type="gene ID" value="VAB18032_05810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05810"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066586_0_0_11"/>
    <dbReference type="OMA" id="VCGDAWA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039248">
        <property type="entry name" value="Ptase_RsbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35801">
        <property type="entry name" value="PTHR35801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="134"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="339" mass="35466" checksum="883DBF1E972303C1" modified="2011-06-28" version="1">MVPLTAEPVTDRGIWFRVETGSPGSALRRAAERLGEQLGLPDGRVADLAIVAAELTSNLIKHAEDGVLLLRPVRRELDAGVELVAIDSGPGMIDLVDSARDGHSTTGTLGIGLGAIVRQASWFDAYSQPGRGTVIAVQVFADAAAERPWVGGVIRPLTGETISGDGYAWRTIGERRQVLVTDGLGHGPLAAAATDAALAAFRAAPAAAPAEVVSHLHRALSHTRGAALAVAEPDPAAGLLRYAGLGNISGVVATGDGRRRGLVSLPGIAGHQRPTIRQYDYPFDADSLLIMHSDGVVDRWRLADYPGLTGRSPLVVAATLLRDAGIRRDDAGVLVARPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCQ4</accession>
    <name>F4FCQ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative monovalent cation/H+ antiporter subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_12170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732217.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12170"/>
    <dbReference type="EnsemblBacteria" id="AEB43548">
        <property type="protein sequence ID" value="AEB43548"/>
        <property type="gene ID" value="VAB18032_12170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12170"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_2_0_11"/>
    <dbReference type="OMA" id="NHSTFKG"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="848"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="891"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="10">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="9">
        <location>
            <begin position="125"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="12">
        <location>
            <begin position="594"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="11">
        <location>
            <begin position="789"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB43548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="946" mass="99296" checksum="835684FDF4F2BC28" modified="2011-06-28" version="1">MLVLLTLHLTAAIVAPLLVRRWGPRACYPLALAPAAAFGWALVRTPDVAHGGAVVETYPWISQLGLDLALRMTTLSWLMTLLVGGVGAVVLVYSARYLPADAVGTAQYAAVMVGFAGAMLGLVLADDLLLLYVCWELTTVLSYLLIGHSAERRSARWAAGQALILTTLGGLAMLVGFIMLGHHAGTYRWSEIAARPLPEGTYLVVAVLLILLGALSKSALLPFTSWLPVAMAAPTPVSAYLHAAAMVKAGVYLLGLLAPVLAGAAPWRPVVLVAGLATMVIGGWAALRQHDLKLLLAYGTVSQLGLLAVTIGVGTADAALAGVAMLAAHALFKATLFLVVGVIDHGAGTRDLRKLSGLGRAAPVLAGVAVLAAASMAGVPPLLGFVAKEAVFAAFTDRPVVLAVLVVGTVLTVAYSLRFLWGAFGSRPGIAPTRLGRIPPTMLLPPAGLALVGLAAGLAAGPVDHLLRPYAESFGPVHAHLAIWSGLNLALGLSVLVLAGGAVVFWLRRPLAPALARVRAPVTGQQGYEWVTHRFDRVAVDVTSVTQRGSLPQYLGLILLVLAAVPGGVLLYIQPWQYPIALWLTPAQPVVLVVISVAALLAVGARRRMTAMLLVGMTGYGTAMFFVLYGAPDLALTQFLVETVTIAVFVLVLRRLPKRFSVRPLWSSRWLRRGIGAIVGLTVAGLAVAAATARHARSISEDFPQLAVEQGHGRNVVNVTLVDIRAWDTLGELSVLVVAATGVASLVFQRSRTGPRPRRLDVDRGEVLAGRPVWLRGGATLHERNRSLVLEVVTRLIFHTAVLFSFYLLFSGHNAPGGGFSGGLVASLALTMRYLAGGRYELAEAAPVNAGTVLGAGLAVAVGGALASMFAGGEALESAKIDFWLPLVGDFYLVTSLFFDVGVYLVVIGLALDVLRSLGAEVDRNIESSGGRPGVLAVERGRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCR1</accession>
    <name>F4FCR1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_12205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732224.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12205"/>
    <dbReference type="EnsemblBacteria" id="AEB43555">
        <property type="protein sequence ID" value="AEB43555"/>
        <property type="gene ID" value="VAB18032_12205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12205"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="OMA" id="KPAVHHW"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="284"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="37804" checksum="A2E3B184E7E436D0" modified="2011-06-28" version="1">MSTGFALITSVILLALNGFFVAAEFALVASKRYRLEQAAVGGGRAAKAALDGVRELSLMLAGAQLGITLCTLGLGALAEPAIERLVGPLLHAVGLPSGASHVIALIFALSLVTFLHLVVGEMAPKSWAITHPERSALLLALPFRAFARVARPVLSALNAVANAMLRLAKVNPQDQLAQVHGPDELRMLLEQSREHGLLGAAQHELLTSMLELQGTTVAQVMEPFDRMVTVRRDDPVERIEQVSRDSGRSRLAVLDAAGDVCGLVHVREAVRAAAVRPDATAADLMNDAITLPDSATVTEAVAVMRARQSQLAMVRNGAGPTRPVGFVALEDLLEEVIGEFDDETDPIPRAVRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCX6</accession>
    <name>F4FCX6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18530"/>
    <dbReference type="EnsemblBacteria" id="AEB44808">
        <property type="protein sequence ID" value="AEB44808"/>
        <property type="gene ID" value="VAB18032_18530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18530"/>
    <dbReference type="eggNOG" id="ENOG503247M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962927_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="29142" checksum="D0353C4B56741E90" modified="2011-06-28" version="1">MGALDDAEREAFEAHLADCWHCLDEAAEIGPSISGLAGLADVDWSLPTDAAPSDFSAEAGSVPSGSGPAASTDAPEPTVPAQVRSPGVAELQQSDAPDNPGPADGTAGPTEVPMPRQRGGAASPAPVRPSGSRPTGRRTSGTRPATTAGSWYRRRGLWAAAAAVVLALAGGVVAINEWTTRADPVLTGTGEAPGYGASLSVVITAGDQGSSTIRITATGLRQGTRYRLFAVTRDGATHVVRDWTATSGPQEVAGETSLPVDELSFITVGLTDGSAIVTAPIAGSPASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCY5</accession>
    <name>F4FCY5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18575"/>
    <dbReference type="EnsemblBacteria" id="AEB44817">
        <property type="protein sequence ID" value="AEB44817"/>
        <property type="gene ID" value="VAB18032_18575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18575"/>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019823_1_0_11"/>
    <dbReference type="OMA" id="AWHATES"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="591" mass="62732" checksum="1DA73532FBC1F4D1" modified="2011-06-28" version="1">MSSGALFRLGAGWPRGASGARTAMSDLVVPAAADQDREPDEGGRVSARSLRRQRRRQAQQDAAEQRYLRRLARANREDSVPHRGSYALGGGRVAAVDPPTMWRATTVQACGLWPFASGSGAPMTGIPLGQHIHTGATVCGDPLNWFTRARYISNPSLFMLGMPGLGKSTLINRMLIGLSAQGVVPLVLGDLKPDYADTVRALGGQVISIARGVGGLNILDPGAMGAAAAKIGGQAGNALAAETHGRVLNMVAALLTIVRGGPISDHEQSVLSACLRHLRERTPQGRTFRLPQLLAVLEEGPPRVRQVTLDRGQESRYRDAVDPLHRSLLGILDGPLGDTFAAETSTRIDPDATAVCIDISRIGEADGQLTAAAMLAAWSDGLGTVAASHALADAGLAPRRWFFTVLDELWRPLRAASGIVDRIDALTRLNRSLGLADAKITHTLKDAEALGSEADKAKARGFVERAGMVACAGLPRAEMEELGRVVGLSRREIDLVSSWSSPPGWAQDGGNEEPPGRGRFLIKVGGRPGIPIRVAITDTERHLHDTNTRWIANGDADRLLAERAAAVRAVTGGDLIAGDPDGWRHDGPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD27</accession>
    <name>F4FD27_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_18785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733514.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18785"/>
    <dbReference type="EnsemblBacteria" id="AEB44859">
        <property type="protein sequence ID" value="AEB44859"/>
        <property type="gene ID" value="VAB18032_18785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18785"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_4_1_11"/>
    <dbReference type="OMA" id="IINMPSF"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="25770" checksum="38065638BF4D0A5D" modified="2011-06-28" version="1">MTTAIMPHRPGARALLVLVGCEARMVVRDTAGLVVPLGLPLLILLTSAGSAGNQVVADGRTALEVYVLPLVVTMVVAMIGIINMPSFLAYYRRSGILRRLAVTPLSPALVLAAQAIVSVAQTLVGITVAAGVAVLLFDARPPADVAVALGVLALTMAAMYAIGMLVAAVAPTPNSAVALGLVAFFLLGALGGMFGGRQALPDPLADLGGWLPFGAAVDAISSAWTGAAVDATALLGLGATVLLGTLVAALLFRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD47</accession>
    <name>F4FD47_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24895"/>
    <dbReference type="EnsemblBacteria" id="AEB46077">
        <property type="protein sequence ID" value="AEB46077"/>
        <property type="gene ID" value="VAB18032_24895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24895"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070456_2_1_11"/>
    <dbReference type="OMA" id="GQHFFIR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="49"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="29465" checksum="868AFAB2A5037294" modified="2011-06-28" version="1">MERIVDHAHFDPAGAMPDRHPSPAPDDVVWVLPGGTGDAPHHTSLLVLPHSGGNAHAYAPWRDLLPEGVRLLVGQYPGRGARFSEPLPETMADLVDPVLASLPADTDDLVVLGHSMGSLVAYEVARALTEAGRPPRALVVSACRAPFLVNPSPVHPENLDDEALVAAIKERGGTENGILDEPELRELVLPSIRADFAIDDAYHSPPAAPLACPVVVFGGSTDPVVPADALGRWAEITDGPVTTHVLPGGHFYFNDQLEDFLTLVTGVLDGCAVRPEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD54</accession>
    <name>F4FD54_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferredoxin-dependent glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734736.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24930"/>
    <dbReference type="EnsemblBacteria" id="AEB46084">
        <property type="protein sequence ID" value="AEB46084"/>
        <property type="gene ID" value="VAB18032_24930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24930"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592672_0_0_11"/>
    <dbReference type="OMA" id="IWIKLGP"/>
    <dbReference type="OrthoDB" id="840288at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="3">
        <location>
            <begin position="211"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="439" mass="46400" checksum="DECE46E0F26E50C3" modified="2011-06-28" version="1">MSAEGATQRGGVYAPGLPEGLIRQRAREGVAAVFPPVDTYGRQLHGAGDEESPGPASVSDDLDQARLVPPVFMPRRLEKLIDLGREPLHDDVDLDTVIGGFRSPLPVYVSAFGSTRVASGDAGIAASRQAGRLGIPMVIGENMVPVGGYRRAEAAQSPILARLRAYAQECPPGVGGVVVQQSTEDADSEVWNLVYSDTSVRELRDSGRLGFELKTGQGAKPGLGGMTAVDAEEAARLAGQFAVRDVLGPDRWLRCATPGTFTEEILRQQVRFMRNNFPRARVWVKFHPGRDVAQAATTAWQAGSDAVTVDGAQGGTGWAPRAFLDQVGLPLGECLRRIGHPQGCLLATGRIWEGGRAVRALALGATAVGLGRAALLAVDEDPENGLIRLVEALALEARLLVSAVGKYRADALTAEDLWWPTAAPTAAWPARTAPIGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD99</accession>
    <name>F4FD99_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25155"/>
    <dbReference type="EnsemblBacteria" id="AEB46129">
        <property type="protein sequence ID" value="AEB46129"/>
        <property type="gene ID" value="VAB18032_25155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25155"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_9_2_11"/>
    <dbReference type="OMA" id="RKFPASM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="159"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="32738" checksum="5B4714A722F0E4D5" modified="2011-06-28" version="1">MNTRTPSIGRGILYICVAAIAWGTGGAVAAILYATSGLGPIAVSFWRFAGGVLLLLTVHLLVRGRTPASGEVNWRQVVVTGVGLAVYQTAYFAAVGYAGLAIATVVTLGAGPILIATGSHLLVGERLGRSGTVLVAMALAGLVLLVGGGTDGAGSAPMPGLLCALLSAAGYAGVTLLGRKVGRDGTSGSPQITTLGGFAVGMVCLFPLALVEGLLPTSGETGQVLGLLAYLGLVPTALAYRLFFAGLATVRATTTSVVALVEPVTAAVIAVLLLHERLTVPAVAGSAILLGAVVALTIGERRAVRLGHVADSGLSLPGQRNSEERAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDG3</accession>
    <name>F4FDG3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dead/deah box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_01450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736010.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01450"/>
    <dbReference type="EnsemblBacteria" id="AEB47374">
        <property type="protein sequence ID" value="AEB47374"/>
        <property type="gene ID" value="VAB18032_01450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01450"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_27_2_11"/>
    <dbReference type="OMA" id="EHKDGQR"/>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="56"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="259"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="563" mass="60688" checksum="BDAE674EC69DEACF" modified="2011-06-28" version="1">MSELTQDLTEGQELAPTAPVRPEAPTFAELGARAETVEALAAAGITRAFAIQEYALPIALRGADLIGQAPTGTGKTLGFGVPLLERVFAPGEGSGDGLPQALVVVPTRELGIQVAKDIAAAGRTRGVRVLPIYGGVAYEPQVEALRKGVEILVGTPGRLLDLAKQKHLRLNGIRALVLDEADRMLDLGFLDDVERILAMLPEDRQTMLFSATMPDPIVTLSRRFLRHPITIHAGHTAETGPSPQTEQLVYRTHSMNKVEIVARILQAESRGLTMIFTRTKRAADRVAEDLDFRGFAVAAVHGDLGQGARERALRAFRAGKIDTLVATDVAARGIDVTGVTHVINYDCPEDQDTYTHRIGRTGRAGASGVAVTFVDWDDMPRWRIIDKTLGLDMPEPQETYHTSPHLYTDLHIPTDVTGTLPTAERTRAGLSAEVEEDLGGGRSRRSEPRGGRRRERGRGEGRERGEGRDRGAGRTRQDGDADPVTTESADPTGEGSSRTPRRRRRRRAGEVVTGTDAATSAADTTTETSAGTESATGEAPRPRRRRRRRGVASTAGTAAEATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDG5</accession>
    <name>F4FDG5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47376">
        <property type="protein sequence ID" value="AEB47376"/>
        <property type="gene ID" value="VAB18032_01460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01460"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123344_0_0_11"/>
    <dbReference type="OMA" id="EKHHIRD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="129" mass="14300" checksum="DEFA2E219C64DF7E" modified="2011-06-28" version="1">MAFARFVRRAIDDAREERGWTVTDLAAHTGVGRSTVFRWLAGDWQDYPELAKVRGFCAALDLPVAAAFRALGLPDTGSGPVRLGSEGPVEADVRVILQRLADPTVPAEEKHHIRDLLRYLARRPIRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDM8</accession>
    <name>F4FDM8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731064.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06335"/>
    <dbReference type="EnsemblBacteria" id="AEB42391">
        <property type="protein sequence ID" value="AEB42391"/>
        <property type="gene ID" value="VAB18032_06335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06335"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_3_11"/>
    <dbReference type="OMA" id="PIKLMGI"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12138" checksum="66DDD43D5C019CDE" modified="2011-06-28" version="1">MELSLATRTVGEHTVLEVGGEVDVYTAPRLRERLLELIDSGARHVVVDLGRVDFLDSTGLGVLVGALKRLRTADGTFSLVCDKEPLLKIFRITALDQVFPLHPTVEAATGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDP0</accession>
    <name>F4FDP0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA polymerase III, delta prime subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_06395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731076.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06395"/>
    <dbReference type="EnsemblBacteria" id="AEB42403">
        <property type="protein sequence ID" value="AEB42403"/>
        <property type="gene ID" value="VAB18032_06395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06395"/>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_4_1_11"/>
    <dbReference type="OMA" id="GFCDGCH"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="45"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="41606" checksum="F77455F2538535F1" modified="2011-06-28" version="1">MPDAFADLVGQDEAVDTLRRAAAAAAAVLRTPQEAVSGADPGAGMTHAWIFTGPPGSGRSVAARAFAAALQCEHGTGCGQCPGCHTTLAGTHADVRLVVPDGLSIGVNEMRALVLRAASTPSGGRWQVVIIEDADRLTEAAGNALLKAVEEPPPRTVFLLCTPSTHPDDISVTIRSRCRVVPLVQPAADAVAEVLVRRDGIAPDVARWAAAATQGHVGRARRLAGDPQARARREAVLAVPRRLTSVGAAFDAASALIEAAEAEAEAAVVEIDAAERAALETALGAGGTGRGAASAARGSAGQLKDLERRQKSRATRAQRDALDRALVDLAAFYRDALTMAMGAPVPPVHTDTAELADAGARSWQAEGALRRLEAVLACRTAIEANVKPRIAVEAMMLALWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDS1</accession>
    <name>F4FDS1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iron (Metal) dependent repressor, dtxr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_12440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732271.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12440"/>
    <dbReference type="EnsemblBacteria" id="AEB43602">
        <property type="protein sequence ID" value="AEB43602"/>
        <property type="gene ID" value="VAB18032_12440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12440"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_0_0_11"/>
    <dbReference type="OMA" id="DAQLMYT"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="25320" checksum="BF1CF5ADBB503D28" modified="2011-06-28" version="1">MKSHDLVDTTEMYLRTILELEEEGVPPLRARIAERLRQSGPTVSQTVARMERDGLLTVEGDRHLSLTPLGRSTAVSVMRKHRLAELLLVNVIGMPYEEAHEEACRWEHVMSDAVEKRVYDLLNRPTRSPYGNPIPGLEDLGSPGETEPEPVEGERNLAFPGLTGKVIVRRICESVQTDAEVLRQLHAAGVDPGAMVTVAQERDGVSIDRSGESIRLPREVASRVFVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDS3</accession>
    <name>F4FDS3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_12450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732273.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12450"/>
    <dbReference type="EnsemblBacteria" id="AEB43604">
        <property type="protein sequence ID" value="AEB43604"/>
        <property type="gene ID" value="VAB18032_12450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12450"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_0_11"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="5">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="42240" checksum="2F878DF5A494AEDD" modified="2011-06-28" version="1">MSEDTVVVWDESLLAYDLGDHPLDPVRVELTIALARELGVLQRPGVRLIRPWPADDALLTRVHDQRYLDAVRMAPREPFFSGFGLGTSDNPVFDRMHESSALIAGATVAAAEAVWWGQARRAVNVAGGLHHAMSDRAAGFCIYNDPAVAIARLLDLGAERIAYVDVDVHHGDGVQQIFWDDPRVLTVSLHETPLALFPGTGFPDETGGPGAEGSAVNIALPPAVSDAGWQRAFHAIVPSVLRAFRPQVLFTQCGADAHRSDPLADLHLSVDGQRATYLALRALADELCEGRWVATGGGGYALVEVVPRAWTHLLATATGAPLDPATLTPPAWRALAAARRPGSDVPLRMTDGIDPGYEPWQPTGEPNPVDRAIAATRKAVFPLLGLDPHDPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDV7</accession>
    <name>F4FDV7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_12620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732306.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12620"/>
    <dbReference type="EnsemblBacteria" id="AEB43638">
        <property type="protein sequence ID" value="AEB43638"/>
        <property type="gene ID" value="VAB18032_12620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12620"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_0_11"/>
    <dbReference type="OMA" id="QRCNVVI"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="139"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="25132" checksum="E6E7C28563483B9F" modified="2011-06-28" version="1">MIMRIAIAGAGNVGRSIAQELIENGHQVMLIERQPRMLRPERVPDARWVLADACELTSLEEADLAGCDVVVAATGDDKANLVVSLLAKTEFAVPRVVARINRAENEWLFTEQWGVDVAVSKPRVMAALVEEAVTVGDLVRLMTFRQGEANLVEITLPPTAPYVGQPLRAVPLPRDAALVAILRGKRVLVPSPDDPIEAGDELIFVCTTEVEDAVRAVVLGPDSVERTRESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDZ4</accession>
    <name>F4FDZ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732343.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12805"/>
    <dbReference type="EnsemblBacteria" id="AEB43675">
        <property type="protein sequence ID" value="AEB43675"/>
        <property type="gene ID" value="VAB18032_12805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12805"/>
    <dbReference type="eggNOG" id="COG4312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066898_1_1_11"/>
    <dbReference type="OMA" id="TWGPTSR"/>
    <dbReference type="OrthoDB" id="1567592at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="241" mass="27694" checksum="C0CACCDCD54011E4" modified="2011-06-28" version="1">MENIDSSPLPPIVDRETWLRERDALLPREKAHTREGDAIAAARRRLPMTEIQPVELIGERGLTSLPDIFEGRDQLVVYKHMWHLGKPLEGQCEGCTLSIWDFQNAVYLEECGITFAVFCEGPYEEIAPFREFMGYTHPWYSTYGVDEPAFADNGAIACYLRQHDRVFLTYETTSRGVEAIMGSLKLLDMTVYGRQEEWEDSPEGWPQRPPYSFWRRDGRPTAQWTRPQVTPVTPAGASHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE38</accession>
    <name>F4FE38_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733562.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19025"/>
    <dbReference type="EnsemblBacteria" id="AEB44907">
        <property type="protein sequence ID" value="AEB44907"/>
        <property type="gene ID" value="VAB18032_19025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19025"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039832_0_0_11"/>
    <dbReference type="OMA" id="YYAVGMK"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="439" mass="45387" checksum="F26BD9DA81B163DA" modified="2011-06-28" version="1">MAGRVNGPYPVVVIGAGPVGLAAAAHLHERRLPFTVLEAGPSAGAAVAEWGHVQLFSPWRYNVDHAARRLLEAAGWVGPDPDLLPTGAELVEAYLRPLATLPQIVPHVRYDAPVAAIGRAGVDRVRTAGREQAPFVVRLETGEDVLAAAVVDASGTWRTPNVLGANGLPAHGETDPQTRTFVDPALPDVLGVDRDRYAGRHIVVVGAGHSAANTLLALAELAAQEPGTTVTWATRGGSIGRAIGGGDADALPGRGALGTGVKLLVDSGRVRLVPGFAVHAVAAVDGRIQLTAADGRTVTADRIIAATGFRPDHRIAAELRLDLDPVLGCTRALAPLIDPNDHSCGTVRPHGVDELTQPEPGYFAVGMKSYGRAPTFLMATGYEQVRSIAAALTGDWVAARDVQLDLPETGVCSATPSVDLPRAELGLVTASAGGNCCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE62</accession>
    <name>F4FE62_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide chain release factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733586.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19145"/>
    <dbReference type="EnsemblBacteria" id="AEB44931">
        <property type="protein sequence ID" value="AEB44931"/>
        <property type="gene ID" value="VAB18032_19145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19145"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_4_0_11"/>
    <dbReference type="OMA" id="HKRKNWF"/>
    <dbReference type="OrthoDB" id="1381946at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017509">
        <property type="entry name" value="Release_fac_PrfH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03072">
        <property type="entry name" value="release_prfH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="2">
        <location>
            <begin position="109"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="202" mass="22323" checksum="6CC90A69616EAA27" modified="2011-06-28" version="1">MTVRLLLSAGRGPQECAWALAHLLRRLEAEAARQRLRVHRVDTVAGDRPGTYRSVLVEVGGAGVEAFAASWTGTLCWQAPSPYRAGVGRKNWYVTAQPCPADPDATCFEESDVEVVACRTGGPGGQHRNKVSTAVRATHRPTGLVVVVDTERQFSLNRRIALRLLRQRLANRDETAVRDATTARWQLHDRLVRGDPVRGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE76</accession>
    <name>F4FE76_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase, family 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734794.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25220"/>
    <dbReference type="EnsemblBacteria" id="AEB46142">
        <property type="protein sequence ID" value="AEB46142"/>
        <property type="gene ID" value="VAB18032_25220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25220"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005386_0_1_11"/>
    <dbReference type="OMA" id="NCRLPQT"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="899" mass="101196" checksum="C6A528C9EE60D667" modified="2011-06-28" version="1">MVAVVKYPSGIEDVKVITDGSPSAPDAERLRLAQADAGEQDWRAWGPYLSERAWGTVREDYSEHGTAWDYFPHDHARSRAYRWSEDGMAGVCDDRQTFCFALALWNGRDPIIKERMFGLGGDGGNHGEDVKEYWWYEDSTPTHSWMRWRYHYPQAAFPYDELVAVNALRGRDDTEYELVDTGIFDDDRYWAVTVDYAKATPTDLCIVVTVANRGEQADRLHVLPHLWFRNTWGWGLPGTDDRVPRLVGQGSRLLGDHWVLGQIVLEGDGEPTPLLCDNDSNAERLWGLPSRTPYPKDGINDHVVTGADTVNPELTGTKGALHYVLDVPAGAQRQIRLRLTRTAPPPGDGDPPPADLGDGFDAVVWARRAEANRFFAGIIPAKASADEASIARQAIAGLMWGKQFYHFDVKRWLEGDPGSTPPAGRRHGRNSAWWHMTSFDVISMPDPWEYPWYAAWDLAFHCVTIARVDPGFAKEQLLLLLREWYLHPNGQIPAYEWAFGDVNPPVHAWAALKVFEIDGSRDHDFLARMMHKLLMNFTWWVNRKDTGGNNVFEGGFLGLDNVGPFDRSAALPVAGTLEQSDGTGWMAMYALNLLDIAIVLAEHDRTWVDTATKFFEHFAYIAAAAYDQGLWDDEDAFFYDVLRLADGMKVPLKVRSVVGLLPLAAVTRLPARTLHRLPELGARLRWFLTNRPEYASVIGARRIGPDGRQQRLLSMCGPEQIVRLLARMLDTDEFLSEYGLRTLSRAHLDKPFTVTLGGQEFSVGYEPAESTSGLFGGNSNWRGPIWMPTNFLLISALRDHAAFFGDDLQVEYPTRSGVKRTLDEIADDLSARLIALFTRDGWGRRPIYGAAQLFQTHPDWRDLIAFPEYFHGDNGAGLGAWHQTGWTALVADLILTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEC1</accession>
    <name>F4FEC1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734839.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25445"/>
    <dbReference type="EnsemblBacteria" id="AEB46187">
        <property type="protein sequence ID" value="AEB46187"/>
        <property type="gene ID" value="VAB18032_25445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25445"/>
    <dbReference type="eggNOG" id="COG4821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089975_0_0_11"/>
    <dbReference type="OMA" id="IFVEPLM"/>
    <dbReference type="OrthoDB" id="1605411at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="25778" checksum="1BDB140C66FB8BC6" modified="2011-06-28" version="1">MISAQGYADAVRPVLDHIVDAGAEPLGRAADLIADSLRAGGVLQAFGAGHSEAFAAELVARAGGLVPANRISLHDLVLHGDAPRDVLTDPKLERDPAVAHQLYEIAAPQPQDVFVVASQSGINGSVVELALLATGRGHPLIAVTSVEHTGRVAPRHPSGRRLVELADVVLDNGAPYGDALLPLEGGGAVCAVSSVTSALLAQLLTAEVVRRFHQVGEVPPIYLSANVPGGDAHNLALESRYAGRLRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEE5</accession>
    <name>F4FEE5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734863.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25565"/>
    <dbReference type="EnsemblBacteria" id="AEB46211">
        <property type="protein sequence ID" value="AEB46211"/>
        <property type="gene ID" value="VAB18032_25565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25565"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063235_1_0_11"/>
    <dbReference type="OMA" id="VSYHLQI"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="246"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="34623" checksum="17C6944A43D7B0B0" modified="2011-06-28" version="1">MITLRLGAADLTRIRFGSRPHPVGTAILASQALRDPVVAARMPGLAARAQAASASTAALRHLLPARGLLPDFLTPLHGIESVAAGIESIMATPRRRITAELTEAYAKLPPSLWRRRFVAADPQILELLTRAVDRYFDAVLAPSWSQLTAAHRGHVEHRSRTYARSGVDGLLNELHPSIRWRPPILEIDSWWSAELTGTGEGILLIPGPLAGLRPRVLVRPGQPVLLVYPVDPPPESPPTRHDPLAQLLGGTRAAVLRQLGEPGRHTTTTVSRLVGISVSSASEHTAALRGAGLVDSERVGGAKVHRLTPLGIHLLAGDVSSTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEJ0</accession>
    <name>F4FEJ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, fmdb family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736067.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01740"/>
    <dbReference type="EnsemblBacteria" id="AEB47432">
        <property type="protein sequence ID" value="AEB47432"/>
        <property type="gene ID" value="VAB18032_01740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01740"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_4_2_11"/>
    <dbReference type="OMA" id="RYEYRCR"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="72" mass="7034" checksum="5928BEC22BB441B6" modified="2011-06-28" version="1">MPRYEFRCRACGDTFEVNRPMAQAGEPASCPAGHTDTVKLLSTIAVTGRGAGAAGAAPAPSGGGCCGGSCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEJ7</accession>
    <name>F4FEJ7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rex</name>
        <name evidence="9" type="ordered locus">VAB18032_01775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736074.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01775"/>
    <dbReference type="EnsemblBacteria" id="AEB47439">
        <property type="protein sequence ID" value="AEB47439"/>
        <property type="gene ID" value="VAB18032_01775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01775"/>
    <dbReference type="eggNOG" id="COG2344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061534_0_0_11"/>
    <dbReference type="OMA" id="HEQRKAG"/>
    <dbReference type="OrthoDB" id="1872374at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="95"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="106"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="26472" checksum="3C74D064D5C79757" modified="2011-06-28" version="1">MSQHRHPGTPGRAGGVPALPDLPEATVARLPEYLRALHNLAETGNETVSSEGLANAAGVNSAKLRKDLSHLGSYGTRGVGYDVALLIEQIEYVLGLTQRRAVALVGVGNLGHALAGYDGFASRGFRIAALLDADPARVGEEIHGMVVRHVDELPQVAAEESIAIGVIATPASAAQRVADQLVAVGVTSILNFAPCVLSVPDGVDVRKVDLAIELQILSFHEHRKASLTGLPRTGGSALTALPGGLAVTEGQEAIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEQ7</accession>
    <name>F4FEQ7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdxH</name>
        <name evidence="10" type="ordered locus">VAB18032_06635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06635"/>
    <dbReference type="EnsemblBacteria" id="AEB42451">
        <property type="protein sequence ID" value="AEB42451"/>
        <property type="gene ID" value="VAB18032_06635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06635"/>
    <dbReference type="eggNOG" id="COG0259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_2_11"/>
    <dbReference type="OMA" id="PEPNAMV"/>
    <dbReference type="OrthoDB" id="1542844at2"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="8">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="9">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="5"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 6">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="56"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="23254" checksum="4941F56D09A214F8" modified="2011-06-28" version="1">MRHEYDAGSGLLEADLAGDWCTQFDRWFAEAVAAGLPEPNAMVVGTADATGRPSARTVLLKGYDQQGFVFFTNYRSRKGAEVAVNAYASLVFPWFPMQRQVIVTGSVERIDRATTEEYFASRPRGSQLGAWASTQSSVLPDRAALDDSYRAAAQRFAEVAPIPAPEHWGGLRVRPDSVEFWQGRASRLHDRLRFRRTDSDWVVERLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEV6</accession>
    <name>F4FEV6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum ABC transporter, periplasmic molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06880"/>
    <dbReference type="EnsemblBacteria" id="AEB42500">
        <property type="protein sequence ID" value="AEB42500"/>
        <property type="gene ID" value="VAB18032_06880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06880"/>
    <dbReference type="eggNOG" id="COG0725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065520_0_1_11"/>
    <dbReference type="OMA" id="VCAPQVP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="29268" checksum="9C6FF43F29ECBA6F" modified="2011-06-28" version="1">MTALVDWLARRPTLRLAGSVNVVSTAKTCTRLRTTLAAAGVLAVLLVTGCADDRAEPPVAGDGIGGELTVFAAASLTESFTRIGQDFQAANGVRVTFSFAGSSTLAAQINQGAPADVFAAAAPAPMATVVDAGNAAEEPVTFVRNQLVIAVPKGNPDGVTSLRDLTGPDRKVALCAEQVPCGAAARAALDAAGVALTPVTLEQDVKAALAKVRLGEVDAALVYRTDARAAAADIDGVEFPESVEAINDYPIVVLTEATNPAAARAFVEYVRADPGRAVLTSAGFQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEW5</accession>
    <name>F4FEW5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_12815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732345.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12815"/>
    <dbReference type="EnsemblBacteria" id="AEB43677">
        <property type="protein sequence ID" value="AEB43677"/>
        <property type="gene ID" value="VAB18032_12815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12815"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043648_0_0_11"/>
    <dbReference type="OMA" id="ITMPPEP"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="9">
        <location>
            <begin position="201"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="34455" checksum="84073600D04AA6DD" modified="2011-06-28" version="1">MSESPDEPAVWLQRAFDEHRRELHVHCYRLAGNVTDADDLVQETFLRAWRARDRFEGRASARTWLYRIATNVFLDSRKAAGHRTVPYGDPLEWSTELGPYPDALLADDPQTGLAARETVELAVIAALRYLPPRQRAAFVLRDVYGWTPQEIAAALDTAVAAVNSLLQRARHTLRRHAPSDPKDWRRPQLTSEDEEILRRYANAKDPETVRALLAEDVRITMPPEPPVVGIDAAAEFLGRPLDWRTFPTSANGRPALINYLRRPGSPRYEALVVDVLRIENGKIVESNAFIGARHVAAFGMPATLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEX9</accession>
    <name>F4FEX9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732359.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12885"/>
    <dbReference type="EnsemblBacteria" id="AEB43691">
        <property type="protein sequence ID" value="AEB43691"/>
        <property type="gene ID" value="VAB18032_12885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12885"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068637_2_0_11"/>
    <dbReference type="OMA" id="LSFEYQR"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="30670" checksum="BF83DD31CB5CDDC7" modified="2011-06-28" version="1">MGRRRDTERVTEQVDTGLAELTPDPDRPGSWTLMLDGAPQSHVDLNDPTHLEFEYVRRLAAAFDLIAPAGAPLRVLHLGGGALTLPRYVAATRPGSAQRVVEVDAALVDLVRRALPWRADARLKVRVDDARAALTGTRDDSYDVVVADVFAGARTPARLTSVQYAAEVARVLRPGGWYLANLADGPPLRYARGQVATVRTVLPRGCLVADAAVLRGRRYGNLVLVAGRQEPPVAELTRRAAGDWFPGRVLAGADLDHFVGGAAVVHDEQATDSTPPPSGIFSVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF87</accession>
    <name>F4FF87_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19450"/>
    <dbReference type="EnsemblBacteria" id="AEB44992">
        <property type="protein sequence ID" value="AEB44992"/>
        <property type="gene ID" value="VAB18032_19450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19450"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_2_11"/>
    <dbReference type="OMA" id="RTEAFNE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="32"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="345" mass="36591" checksum="2B46C2CBA79FEAF4" modified="2011-06-28" version="1">MGVATMLAASATFAAGCGNDATGGSGSELLVGVDYPRSDTDFWNSYITYVPQFASELGVDLKTTNSQNDIANLISNTQTFMSQGVKGVVMAPQDTAAIAPTLAQLDDKKIPVVTIDTRPDTGNVFMVVRADNRAYGTKACQFLGTKLGGKGKVVMLQGGLDSINGRDRTEAFNECMQRDFPGITVFGEATDWKADVAASKLQTRFASDPDIKGIYMQSSFALSGTLQILKQRGLQVPPTDPRHVFVVSNDGIPEELKNIGAGLIDATVSQPADLYAKYGLEYVKAAIEGKTFQPGPTEHGSTIIQVRDGLLEDQLPAPLVTLDGAPIGGEPTTKFDDAALWGNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFC5</accession>
    <name>F4FFC5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="9">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_25645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:18179"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:10242"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734879.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25645"/>
    <dbReference type="EnsemblBacteria" id="AEB46227">
        <property type="protein sequence ID" value="AEB46227"/>
        <property type="gene ID" value="VAB18032_25645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25645"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_10_1_11"/>
    <dbReference type="OMA" id="GILDMIH"/>
    <dbReference type="OrthoDB" id="762291at2"/>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050343">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB46227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="26719" checksum="2AC526CF78A0B3DB" modified="2011-06-28" version="1">MSGLLAGKRLLVSGVITDASIAFSVAKLAQENGAQVVLTGFGRLSLVERIAKRLPETAPVIELDVTNPEHLAGLADSVREHVDGLDGVVHSIGFAPQSCLGGGFLDASWEDVATALHVSTYSYKSLATAALPLMSPGGAVVGLTFDATQAWPVYDWMGVAKAGLESASRYLALHLGKQGIRSNLVAAGPLRTMAAKSIPGFEQFEDAWSERAPLGWNLTDQEPAARACLALLSDWFPATTGEIVHVDGGYHAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFJ8</accession>
    <name>F4FFJ8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tpiA</name>
        <name evidence="5" type="ordered locus">VAB18032_26010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734951.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26010"/>
    <dbReference type="EnsemblBacteria" id="AEB46300">
        <property type="protein sequence ID" value="AEB46300"/>
        <property type="gene ID" value="VAB18032_26010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26010"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_11"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="263" mass="27786" checksum="CC7420E693892473" modified="2011-06-28" version="1">MASAPRRPLMAGNWKMNLNHLEANLLVQKLAASLTEKQLTEVETVVLPPFTDLRTVQTVVEGDKLLIGYGAQDLSAHASGAYTGEVAGSMLAKLGCTYVVVGHSERREYHREDDALVGAKVQAALANGLTPILCVGEGLDVREQGGQVAHCTEQLDAALKGLSAEQVTKVVVAYEPVWAIGTGKTATPEDAQEVCGALRTRLAETFDQATADQVRVLYGGSVKSSNVASIMAQPDVDGALVGGASLDAEEFAKICRFPEHITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFU9</accession>
    <name>F4FFU9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiazolinyl imide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731202.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07025"/>
    <dbReference type="EnsemblBacteria" id="AEB42529">
        <property type="protein sequence ID" value="AEB42529"/>
        <property type="gene ID" value="VAB18032_07025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07025"/>
    <dbReference type="eggNOG" id="COG4693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065125_0_0_11"/>
    <dbReference type="OMA" id="CATHYAL"/>
    <dbReference type="OrthoDB" id="1434450at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010091">
        <property type="entry name" value="Thiazolinyl_imide_reductase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017494">
        <property type="entry name" value="Thiaz_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01761">
        <property type="entry name" value="thiaz-red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="377" mass="41276" checksum="20EE27E8A991F0FC" modified="2011-06-28" version="1">MRQRPRVVVCGARFGQVYLEAFRNPELPFELAGVIAAGSERSRACARRYDAPLYTDPEQLPDDIDMACVVIRGGLLGGRGSELARALMARGIHVLQEHPLHHDELAENLRTARRHGVVYHLNPFYTHVAPVRRFVAAAQELLRRQRPLYIDAAAGFQLAYSLLDILGQSLGGVRPFAFGDLSATTPTVAAATSLDIPFRSLDGVLAGVPTTLRIQNQMDPADPDNYAHLMHRISIGTEAGNLTLVNTHGPVVWSARPDFPREVADPNADPHYATMPDDAQAPSAVVLGPATVPSYRHIFRSLWPAGIAHALTELHQAVEERQDPLRRGQYHLSLCKLWQDLTLRLGPPELLSSTPPEPLTDDDLKAIAAAGDEAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFY9</accession>
    <name>F4FFY9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731242.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07225"/>
    <dbReference type="EnsemblBacteria" id="AEB42569">
        <property type="protein sequence ID" value="AEB42569"/>
        <property type="gene ID" value="VAB18032_07225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07225"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_5_0_11"/>
    <dbReference type="OMA" id="KGKNFYH"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="346" mass="37613" checksum="A0C8954EA58A6CFE" modified="2011-06-28" version="1">MRLGMPLNYRAGIVDIADELVDFEQAGLDLVLVAELYTFDAVSQLGFIAGRTRRLGIASGVMQLYTRTPTLIATTAAGLDHVSSGRFTLGLGTSGPQVIEGFHGVPFDAPLARTREVIEVCRRVWRREKLVHQGTHYRIPLPEGQGTGLGRPLKLINKPVRERIPITLAAIGPRNVELAAELAEGWQPAFFHPERSAAVWGESLARGAQRRDPSLGPLDVSVNALLAIGDDVTGLRRLARQELALYLGGMGAVGANFYNTLAQRYGFGEAARTVQELYLAGRRDAAAEAVPEELVAGTCLIGPASWVAERLAAYREAGVTTLNVTPLARAHRDRLRLVERLRDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG22</accession>
    <name>F4FG22_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation and cell division protein ssga</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007457244.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13260"/>
    <dbReference type="EnsemblBacteria" id="AEB43766">
        <property type="protein sequence ID" value="AEB43766"/>
        <property type="gene ID" value="VAB18032_13260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13260"/>
    <dbReference type="eggNOG" id="ENOG5032RFA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126599_0_1_11"/>
    <dbReference type="OMA" id="NDEPVEW"/>
    <dbReference type="OrthoDB" id="1627707at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="143" mass="15587" checksum="539F0DCA1A28D163" modified="2011-06-28" version="1">MSVIRPTTVEVETSLRLVAPDATALPVRASLRYDPADPYAVHVLFHAESAGGEAVSWSFARELLVTGLDEPAGIGDVRVWPWATPRGDFVALALSSPDGNALFEVPRSVLVRFLRRTYVVVPRGREAEHLDVDTAVNRLLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGE4</accession>
    <name>F4FGE4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19900"/>
    <dbReference type="EnsemblBacteria" id="AEB45082">
        <property type="protein sequence ID" value="AEB45082"/>
        <property type="gene ID" value="VAB18032_19900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19900"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_1_11"/>
    <dbReference type="OMA" id="VLPGWFQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="33098" checksum="4A80F88464A07471" modified="2011-06-28" version="1">MTMVSAEEGPAAGPTVLRMLLGAQLRRLRESRGVTRESAGWEIRSSESKISRMELGRVGFKERDVADLLTLYGVTAEQERAALLKLARDANNPGWWHRYGDVLPSWFQSYLGLEAAAALIRSYEVQFVPGLLQTREYARAVVLLGHGRASPDEIERRVDLRMHRQELLRRPRPPRLWAVVDEAALRRPIGGPTVMRGQLQALLEATRTPNVRLQVIPFAAGGHAAAGGAFTILRFGDQDLPDIVYIEQLTSALYLDKREDLDFYAVAMERLCVEAEPPERTPEILKRMIAEFDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGH4</accession>
    <name>F4FGH4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_26055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26055"/>
    <dbReference type="EnsemblBacteria" id="AEB46309">
        <property type="protein sequence ID" value="AEB46309"/>
        <property type="gene ID" value="VAB18032_26055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26055"/>
    <dbReference type="eggNOG" id="ENOG502Z7XA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224321_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="25467" checksum="5FDE7281A5D82969" modified="2011-06-28" version="1">MDDTTLVSRFLRDGFVKLAGAVAPRVAADCARLLWRETGCDPDDPATWRQPVHWVEGMAQGPFAAAPNSPFLHHAYDLLVGAGRWEPRYSLGTFPLRFPHEEEPNDAGWHIEGSYLPEGESWYFTNVRSRGRALLMLFLFSEVGEEDAPTRIRVGSHLDVPRVLESTGRTGRAGWNLRPTWWRHPATGHSPSPPGPRATSFCAIRSWCTRRNRTTGHGRASWPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGJ1</accession>
    <name>F4FGJ1_MICM1</name>
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        <submittedName>
            <fullName evidence="9">MMPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_26140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AEB46326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26140"/>
    <dbReference type="EnsemblBacteria" id="AEB46326">
        <property type="protein sequence ID" value="AEB46326"/>
        <property type="gene ID" value="VAB18032_26140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26140"/>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005108_4_1_11"/>
    <dbReference type="OMA" id="IGDRIWW"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307891" evidence="7">
        <location>
            <begin position="43"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="547"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="695" mass="71608" checksum="DECC13931AEEF560" modified="2011-06-28" version="1">MSLFTRVARSRRTAWLTVAVAVLVGVAVFGLPIPSNPAPVSATGLSEQWQSTQVERLQRELPASGVQPAVVVVSRDDGAPLSEADRAAITADTSSLSRLAAGGQVAPPQLSPDNTVALVAVPLDATGGQEAVAERVAQVRAELAGFPGDLTVQVTGPPAFTADLTKVFEGADVTLLAFTAAVVAVLLLITYRSPVLWLVPLVIVAATEQITLRALETIIPAVGINFAGGAVTGIASVLVFGAATNYALLLIARYREELRREEDRFAAMRAALRRTAEPILASGGTVMLGVLTLLLSQQETNRALAVACATGILLAMASALLVLPAALVLLGRRLFWPFVPTVGSVGREGRIWGRLGAAVIRRPVPVAVLATLLLAGLALGGLGIRTGLSETEQFRVKPEAVAGAQTLAGAFPAGTTQPLAVMTNPGAVQAVTAAAAEVPGVASARPGPAGADVAQVDVVLDAEPGTAAANRTLEQLRDTVGAVDNSAPPATAGVDQPSGAVVGGTVAGRYDSAAADAKDLRLILPLILLLVGAVLVLLLRGLLAPVLLVATVVASYFASLGGAWLIFEHVFDFPAMDTGVPLLAFVFLVALGVDYNIFLVTRAREDARSTGTRKGMLSALRVTGGVITSAGILLAAVFAVLGVLPLITLTQIGIIVCLGVLLDTLLVRTVVVPALAFLLGERFWWPGRITPEQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGJ6</accession>
    <name>F4FGJ6_MICM1</name>
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        <submittedName>
            <fullName evidence="7">Integral membrane protein terc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_26165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734982.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26165"/>
    <dbReference type="EnsemblBacteria" id="AEB46331">
        <property type="protein sequence ID" value="AEB46331"/>
        <property type="gene ID" value="VAB18032_26165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26165"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_0_1_11"/>
    <dbReference type="OMA" id="ADHAREY"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="36586" checksum="6D6409FFDCE41046" modified="2011-06-28" version="1">MDVSGLVWAITLVALTAVLLVDLFIIGRRPHEPSVRESSLWVAFYVGLALLFGVGLWLTAGGSVAGQFYTGWLTEYSLSVDNLFVFMIIMARFAVPRQYQQKVLLVGIVLALIMRGGFIALGAALISQFSWVFYIFGAFLIYTAINLARQGESAEDEFQENVLIRWSRRALPISRGYDAARLTTREQGRRMFTPMLIVMIAIGTTDLLFALDSIPAIFGITHEPYLVFTANVFALMGLRQLYFLLGGLLSRLIYLSYGLAVVLGFIGVKLILEALAENSLFFLNGGQPVGWAPHIPIWLSLLAIVGILAVATVASLVKSSRDRRRDLTGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGT0</accession>
    <name>F4FGT0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02530"/>
    <dbReference type="EnsemblBacteria" id="AEB47590">
        <property type="protein sequence ID" value="AEB47590"/>
        <property type="gene ID" value="VAB18032_02530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02530"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594226_0_0_11"/>
    <dbReference type="OMA" id="TGVWNPF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="498" mass="52448" checksum="8FC96F2BE8B91480" modified="2011-06-28" version="1">MVRAVRGAGGYRVPVAKGSGLGVRGWLLLGLTTVVALAATGVWNPFPGMWDWVNRRSPISEPDLVWQQRIGGTPRSVTIAGETVVVEQRTRVEARSLATGSQLWERKADWSAVAGGGAEAVVAVGRLLVKGYEVLDPTTGVTRRRDNDAVAVWTYRNLLLDARCVEATDCTLSAWEPRGVAPLWTAFLPGVSSGLLADNPNLLDSRRLSSPRIHGEVAGPETVPALLGFPVDGRVHVVDTATGRVLQDVEPGRDERLAVIGGRLLRIVARSQDGNCYFTISGRDAATGQETWQRSGLNLRTADSAGCVQREDPYGARNVLVGVAPDGREAILDGYDGRLLLATENSERVLAVDDRYAVVRTAGRDGISGRELSSGQVRWNRPSGEKAGAALTPYAAVVADEKPNRLVALDPRTGRELVALRTSANALAVGPAGMVIGEGREIGYIRFGAASGDPARNGDPGRNGDGSVPGPAGSPGAPGPQGTCGPKNELCDAPDSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGX5</accession>
    <name>F4FGX5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731262.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07325"/>
    <dbReference type="EnsemblBacteria" id="AEB42589">
        <property type="protein sequence ID" value="AEB42589"/>
        <property type="gene ID" value="VAB18032_07325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07325"/>
    <dbReference type="eggNOG" id="ENOG502ZTYW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1756790_0_0_11"/>
    <dbReference type="OMA" id="EACTEVI"/>
    <dbReference type="OrthoDB" id="2018298at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="148" mass="15892" checksum="26DEDFD7CD3CADF6" modified="2011-06-28" version="1">MSGPLPHWCEQTCVVCPAQQLGPGQFDVVERPGPEFAYRQNLGWRATADGVAVCVHPFRVGLPAGRYASAGEPVPDQAPRPAPTPAALELPADVVDLEGWLVAMLRDAPSEQIFTAVARAERLAAQRFGAKQTVAALRRVLSVELANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH11</accession>
    <name>F4FH11_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731298.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42625">
        <property type="protein sequence ID" value="AEB42625"/>
        <property type="gene ID" value="VAB18032_07525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07525"/>
    <dbReference type="eggNOG" id="ENOG5032RN5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1494616_0_0_11"/>
    <dbReference type="OMA" id="TWLSIRV"/>
    <dbReference type="OrthoDB" id="1719611at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="20367" checksum="C622EE55DE6555B7" modified="2011-06-28" version="1">MARTWLSIRVELVSGRGIDLWPRPGRVFAASRSHTFAQLADAIDLAFARWDLAHMHMFTLADQTPVTPLELWDGEAPEGSTDSGRTKLSRLGGGDQFAYLFDFGDDWAHLCTVAESRIDPLEALGGMPAEPMPYFGWGDLPDQYGRRWDGDDGESQPPKPPRRPLADLPPLLPWWGPRQRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHV2</accession>
    <name>F4FHV2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736277.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02805"/>
    <dbReference type="EnsemblBacteria" id="AEB47645">
        <property type="protein sequence ID" value="AEB47645"/>
        <property type="gene ID" value="VAB18032_02805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02805"/>
    <dbReference type="eggNOG" id="ENOG503498K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151322_1_0_11"/>
    <dbReference type="OMA" id="PKGINTE"/>
    <dbReference type="OrthoDB" id="1918051at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="105" mass="10820" checksum="738E65A4F93D8ECE" modified="2011-06-28" version="1">MIAIELMESASSNAAHLLTALASSIPLAAEEPKGINTEGVVTFFASKIAPILLAVLGVIFIGRASRGEISKVLTSSAIAIVGLAFIAGAATLFFIGDFLINLIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHW9</accession>
    <name>F4FHW9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02890"/>
    <dbReference type="MEROPS" id="S13.004"/>
    <dbReference type="EnsemblBacteria" id="AEB47662">
        <property type="protein sequence ID" value="AEB47662"/>
        <property type="gene ID" value="VAB18032_02890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02890"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017692_0_1_11"/>
    <dbReference type="OMA" id="HSDNTLA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="553" mass="55172" checksum="8FDD618EE0AFFB7F" modified="2011-06-28" version="1">MPEAQVLRPQPAVPTGPPAGESPQDAERTQPLTVGVGAGTTRASSPPPPAVGSGPGVPSGVPPEQPRPTSRRRLPVLLAAVLVLVLAVVGLVVVRPGPVERWLADGPAAPSAEPPEPSPVAVLAGTDIGAPMPATDGLRAVLDPLIADTALGGRVHVSVTDALTGQQLFERGGGTGTVPASVTKLLTAVTVLTARGPGYRIPTTAVAGAQPGEVVLVGGGDPTLAAGPKGFYPGAASLEDLAEQVRTALGGTAPTRVVVDSSLYSGPRLEPGWDDDIPTGGYGAQMTALMLDGARKDPKAGQGWAERVNQPDLTAGRAFARLLGVPESEVRSGTAPAGSTETTEATDAPGVTGAPVGATGPGAQLGVVQSPPLIRLVDIMISDSDNIIGEALARQVALARGRPASFTGAASAMTEVLSELGLPTEGLALADGSGLSRRNLISPTLLTETLALAASPDRPELGGIFGGLPVGGWSGTLRDRYGSVPGTAAGAGTVRAKTGTLTGVHAIAGVVTTAEGRPLTFAVLTDRVPADGMEPARGALDRIAAALATCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHX3</accession>
    <name>F4FHX3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase s8 and s53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">VAB18032_02910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02910"/>
    <dbReference type="EnsemblBacteria" id="AEB47666">
        <property type="protein sequence ID" value="AEB47666"/>
        <property type="gene ID" value="VAB18032_02910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02910"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_13_3_11"/>
    <dbReference type="OMA" id="NRMIRTA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313967" evidence="13">
        <location>
            <begin position="37"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="14">
        <location>
            <begin position="82"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB47666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="433" mass="44734" checksum="6DF86ECCA22796AE" modified="2011-06-28" version="1">MRHGRPPGPRRLTGRALLATAATAVSAVVAAVPAAAVPANPTVTVPVAYAPGDVTDRADQIRDEQWQLDKLGARIAWRTSTGRGVTVAVIDSGVDGSHPDLAGRVLPGIDLVSPDGAAEPDPVGHGTTVAGLIAGRNDDRQGVVGLAPDARILPVRVLDEENRYDDALIVAQGVRWAVDNGAQVINLSLGGSGDSPALAAAIDYAFARDVVVVACTGNLATSPDAKVWYPAREPGVIAVSGLERSSNNLWSGAITGRATVLTAPASGLVGARSPAGYWRVQGTSFAAPLVAATAALVRARYPQMSAGDVVNRLLVTAKDIGPTGRDDRFGYGLVDPIAALTADVPLVQHNPLDDNEAPGISGFGPAPGSVPTPDPDADHLGFTAPQQETRWRARAAGAQDSSGTDRLWIGSAILVALVTGALLMVRRFRQSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHX6</accession>
    <name>F4FHX6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02925"/>
    <dbReference type="EnsemblBacteria" id="AEB47669">
        <property type="protein sequence ID" value="AEB47669"/>
        <property type="gene ID" value="VAB18032_02925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02925"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_3_1_11"/>
    <dbReference type="OMA" id="WERPWDR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="241" mass="25833" checksum="690AF453BE50619A" modified="2011-06-28" version="1">MIGGGAMSQPPETARRAPAWLQPLLARLGTARIEDFTQLRTPEHGGRESAVLVLLGEGETGPDVLILQRAATLRNHAGQPAFPGGAADPEDADAAATALREANEEVGLDVSSVTLLTELPRLWIPVSDFVVTPVLAWWHAPHPVHAREPAEVAHVARLPVAELVDPENRMQVRHPSGWIGPAFSVRGMLVWGFTAGVLSGLLDMGGWSRPWFLDRVIDLPPTEAMPAPSAGTDDVDESAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHY1</accession>
    <name>F4FHY1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, crp/fnr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736306.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02950"/>
    <dbReference type="EnsemblBacteria" id="AEB47674">
        <property type="protein sequence ID" value="AEB47674"/>
        <property type="gene ID" value="VAB18032_02950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02950"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_4_11"/>
    <dbReference type="OMA" id="VLCRDFG"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="225" mass="24760" checksum="DFAE17A72BF20816" modified="2011-06-28" version="1">MDEVLARSGIFQGVDPEAAEALAKEMETIEVRKGEVVFNEGEPGDSLYILLSGKIKVGRRAADGRQNLIAVMGPSDMVGELSLFDPGPRTATATAVTDSRLARLRKQALRPWLNNRPEIAEQLLRVLARRLRRTNDALADLIFTDVPGRVAKNLLQMAGRFGTRDGGVLRVTHDLTQEEIAQLVGASRETVNKALADFASRGWLRLDGKSIIILDPERLARRARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1K9</accession>
    <name>F4F1K9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733892.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20690"/>
    <dbReference type="EnsemblBacteria" id="AEB45238">
        <property type="protein sequence ID" value="AEB45238"/>
        <property type="gene ID" value="VAB18032_20690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20690"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_11"/>
    <dbReference type="OMA" id="CGGGEIQ"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="30648" checksum="7A886A6F3EA2242A" modified="2011-06-28" version="1">MAPPRPYTVNAGGFTTRYWESTPPGQPRGTVVLIHDGAFGGDAIGSWSTVMPLLAQHYRVLAPDLLGYGDTDKVVYLDRPPYAFRTAHLAAFCAALDIDAAHFAGQSFGGSLLLRALATPTPELPALSAVSICGTGGPWRTSKGVTELGRFDGTEDDMRRLVALMTDDYPGFDDTIALRYANTRKPGHVTACLAPRLRHPTLTKPDVRDDWPTPLRDSPVPVLVVEATRDDLLEPDWGHHFDNLAPHIHVHRMDARHAPNLDQPDAVADLLLTFFDQGSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F204</accession>
    <name>F4F204_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47751">
        <property type="protein sequence ID" value="AEB47751"/>
        <property type="gene ID" value="VAB18032_03335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03335"/>
    <dbReference type="HOGENOM" id="CLU_3259461_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="42" mass="4341" checksum="7E3061EC817A3130" modified="2011-06-28" version="1">MSALSLFALDLGGLIKLLLSLVLLVTKPLDGVGEEGVCLCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F239</accession>
    <name>F4F239_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736418.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03510"/>
    <dbReference type="EnsemblBacteria" id="AEB47786">
        <property type="protein sequence ID" value="AEB47786"/>
        <property type="gene ID" value="VAB18032_03510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03510"/>
    <dbReference type="eggNOG" id="ENOG5031UFY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119788_0_0_11"/>
    <dbReference type="OMA" id="LHWADEF"/>
    <dbReference type="OrthoDB" id="547727at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025850">
        <property type="entry name" value="SUKH-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14433">
        <property type="entry name" value="SUKH-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="26779" checksum="B1C878274A8C21C7" modified="2011-06-28" version="1">MISRDEALEIARQWAGAGRPGPAPEVFLHEFDLGYVAWRAEPTPAATDGPPAPPPATGYPRAVIDRETGEVSQWPSLPEQTIAERYASRRAAEGRFPPDVRHVLESAGWFPGRDVTSAVDHWMVRFADDLAGLDCPPAARAALVEFGGLTLPQFGRTGRAGAGFTSYLHPTRGGVVTEGARGFAEEYGIPVYPIGNNEDGPSELVMDAQGRVFLLHWADEFLVGPDLDSAVVNLIRGGEMTEASDLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F271</accession>
    <name>F4F271_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_08210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08210"/>
    <dbReference type="EnsemblBacteria" id="AEB42760">
        <property type="protein sequence ID" value="AEB42760"/>
        <property type="gene ID" value="VAB18032_08210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08210"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OMA" id="YARWSGI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="270" mass="29424" checksum="CB92790DF2361E69" modified="2011-06-28" version="1">MASSDPLEDEFRDFVTARSSALLRTAYLLTGDWGTAEDLLQTALTKTYLAWKRLGGIEAIEPYARRVMVNTSTSWWRRRWHGERPTEVLPERPGVDEIEQQLDRDVLWRHLRALPARQRAVLVLRFYEDLSESQTAALLNISTGTVKSQTSRALATLRRRIGADEAFALPGAASSSVDPPRRAGTATRTGQPLPTRQTRPDTSVPATPAPATPTGVPEAAGQPDPAMAAHRQDRSEVAPDMAAQRTAVEGSAQAPAAVAKPDSALAGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F276</accession>
    <name>F4F276_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731436.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08235"/>
    <dbReference type="EnsemblBacteria" id="AEB42765">
        <property type="protein sequence ID" value="AEB42765"/>
        <property type="gene ID" value="VAB18032_08235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08235"/>
    <dbReference type="eggNOG" id="COG3662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059206_1_0_11"/>
    <dbReference type="OMA" id="PYAHELY"/>
    <dbReference type="OrthoDB" id="1395053at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="16"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="31471" checksum="0557AC2E1491D623" modified="2011-06-28" version="1">MESADAGLFGPGSVSWKLHAEPILFVAGLRSLYLQALHPRAMAGVAQNSNYRQDAWGRLIRTANYVGTALYGTTAEAEEAGRRLRRLHARMTAVDPATGERFRIDEPDLLRWVHVTEVESFLDTGRRAGVPLDAAEVDAYYTEQRRVAALVGLDPQTVPGTAAEVAEYYRQVRPELRMTREAAETALFLTAPPLPWKLSLPARIGLNLSPARWAYLGIAGTALALLPAWARRLYGGLGLPTTALSADVTVRTLRLALTALPRDWREGPMRRAAEERYANLASTAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2H9</accession>
    <name>F4F2H9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, cdar</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14695"/>
    <dbReference type="EnsemblBacteria" id="AEB44051">
        <property type="protein sequence ID" value="AEB44051"/>
        <property type="gene ID" value="VAB18032_14695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14695"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017436_0_0_11"/>
    <dbReference type="OMA" id="MSPARTK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="79"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="636" mass="66997" checksum="F70E4B3EBB0F3FD5" modified="2011-06-28" version="1">MSSPLEFLELLAREAAAVEFEGPLVAARSAGLPADQIAELEQAKTVALRVRALLERRRRRESELLSLYDTVSDLAGLRDLDDVLRAIVHRARHLLGADVAYMTLNDAERGDTYMRVTDGSVSARFQQLRLPMGAGLGGLVAQSGAPYVTANYPQDERFHHTREIDAGVGEEGLVAILGVPLRLGSTSIGVLYAANRSARPFVREEVALLLSLAAHAAVAIDTARLLAETRAALAELSSANTTIRAHSSSVERAAAAHDRMTALVLRGGGVEDVAAAVTEVLGGTLLALDAEGRLLARVGALDEPDRADLVEAVAASRTEGRSVRRGEVWYAAVVAGAENLGALVLHPEGELADADQRILERAALVTALLLLFRRTVAEAEGRVRGELLDDLIARPLRDTEALRSRARRLGVDLDAPHVLVAVDDDAIAATGSARQRVLSWATTYASTRGGLAAARDGRVVLMLPGQDAGGSARAVSRDLSRITGRPVTAGASGPVAGPTSLAVAFREADRCLAALGALGRAGQGASTAELGFVGLLLGTVSGDGDADVSQFLATTIGPVVDYDARRGTALVRTLEAYFGVGGSLARAAELLHVHVNTVTQRLERVGQLLGADWQKPEQALQVQLALRLHRLRTPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Q1</accession>
    <name>F4F2Q1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733970.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21080"/>
    <dbReference type="EnsemblBacteria" id="AEB45316">
        <property type="protein sequence ID" value="AEB45316"/>
        <property type="gene ID" value="VAB18032_21080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21080"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056958_0_0_11"/>
    <dbReference type="OrthoDB" id="1687733at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="30375" checksum="F84A0B4CE50BFAE4" modified="2011-06-28" version="1">MTQPDDVTQALPTQQMPPAPPAHPRTPSVSTEEPTVSLHGGEPTVSLGGGEPTVSLDQTVRRMAPNLGATDGDLTVSLAPAGMTTYAPTATGAYAVTHPGQATAAQVAFDTVRTTGAQPGGGAFAAPITDPGGELRFGPGVPAGPPPAPAWPTPVPAPRPRSAWRRLVSVLSTLLTLALIAAVGLWIWQRLDPLEIGEVSIVVPRPAGARCDVTVDVVATVHTNGRAGTIEYQWLRSGSAPGALLRERVGPGQRTVELTLRWSFSGVGSTTETATVNIVSPSSAQAVTEVAYACPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2W0</accession>
    <name>F4F2W0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27491"/>
    <dbReference type="EnsemblBacteria" id="AEB46571">
        <property type="protein sequence ID" value="AEB46571"/>
        <property type="gene ID" value="VAB18032_27491"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27491"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017262_1_0_11"/>
    <dbReference type="OMA" id="GWNRQLD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="550" mass="56968" checksum="A97F78252B5CD6BB" modified="2011-06-28" version="1">MVALAAACAGALGVAYLILPAMGSDLAAQVARADFFAAHGPTPVDLRWYGGVQQFGYSLLAQPVMALLGVRLTGVVALVAAATALAALLVRTRVPRPLLGSLVGVVTIAGNLLSGRITYGLGVAFGLAALLALTWRPTLSPAATTVRHVRSGSRWPLVLAGVGALLASATSPVAGLFVGLAGVALLLSRRYADGLTLAVTAALPLGVTALLFSDGGWMNISRTDTIRATVTALLVAALVGYRPVRVGALLAAGGVVAAALVHTPVGLNATRLATMFALPLLAAAAHRPAWLGSARRTGPPVAQPPPVPPVRPPSVGAMPRRVGAVALAVLLAVVCWWQPPVVPADLRSIGDPTSAPGYFAPLRAELERRGLTGRLEVPPTRNYWEAARLGEVPLARGWLRQADIDRNPLFFTTVPGATGTGVPLTVDSYRAWLDDNAVQYVAVPDAPLSWVGRAEAELVDGGLPYLTEVWSDRHWRLYAVTDPTPLVGAPGELLHADGASVAFRTTGAATVPVRVRHSRWLTASGDATVAADGDWTAVTVPRAGTYTLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3A5</accession>
    <name>F4F3A5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ordered locus">VAB18032_08555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731500.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08555"/>
    <dbReference type="EnsemblBacteria" id="AEB42829">
        <property type="protein sequence ID" value="AEB42829"/>
        <property type="gene ID" value="VAB18032_08555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08555"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_1_11"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="341" mass="37364" checksum="E6631955FCAFB95F" modified="2011-06-28" version="1">MSDVPARPRVFSGIQPTADSFHLGNYLGAVRHWVALQESHDAVYCVVDLHAITAGHDPKVLHQRSRVAAAQLLAVGLDPERCTLFVQSQVPEHAQLAWVLGCLTGFGEASRMTQFKDKSQKQGNERASVGLFTYPILQAADILLYQANAVPVGEDQRQHLELSRDLAQRFNTHFGPTFTVPVPHIVKATAKITDLQDPTAKMSKSSSSPAGIVDLLEDPARSAKKIRSAVTDTGREIVFDEETKPGISNLLTIYSALSGREIDDLVAAYDGKGYGDLKKDLAEVVREFVTPIQARTRSYLEDPAQLDKLLAAGAEKARRLAVPTLLKVYERVGFFPPVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3E2</accession>
    <name>F4F3E2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UMP pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_08740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731537.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08740"/>
    <dbReference type="EnsemblBacteria" id="AEB42866">
        <property type="protein sequence ID" value="AEB42866"/>
        <property type="gene ID" value="VAB18032_08740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08740"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_3_11"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB42866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="210" mass="22627" checksum="522F59596D6A6046" modified="2011-06-28" version="1">MDVIVIDHPLAQSRLTAMRDERTDSSSFRAALHELTTMLVYEAARSFPIERYPVQTPVTATEGTRLANPPLLVPVLRAGLGMADAALGLLPESSMGFVGLARDEETFEPRAYMESLPRDLAGLPVLVLDPMLATGGSLEHCCRLLAERGCTDITVLCVLAAPEGIERLKRSNLPLRLVTAAIDQGLNGSKFIVPGLGDAGDRQFGGMPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3N3</accession>
    <name>F4F3N3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">hisG</name>
        <name evidence="14" type="ordered locus">VAB18032_15145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732806.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15145"/>
    <dbReference type="EnsemblBacteria" id="AEB44141">
        <property type="protein sequence ID" value="AEB44141"/>
        <property type="gene ID" value="VAB18032_15145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15145"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_1_11"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="OrthoDB" id="1419568at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="49"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="206"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB44141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="30474" checksum="9349B2A2BFC4CBFC" modified="2011-06-28" version="1">MLRVAVPNKGALASSAAEMLREAGYRQRSDPKDLVCRDEANDIEFFYLRPKDIATYVGSGDLDVGITGRDLLIDSGAPAEEVVDLNFGRATFRFAARPDDVDDVQELGGHRIATAYPGLVERHLAELGVKAEVIRLDGAVENAIRLGVADVVADVVETGATLRQAGLVVFGEPLLRSSAVLVRRAGATAHPQAEQLLRRLHGVLVARRYVMLAYDVPAGLLDRASSLTPGIESPTVSPLHREGWVAVQAMVLRDDVHRIMDELYELGARAILVTNIHACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F478</accession>
    <name>F4F478_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736523.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04045"/>
    <dbReference type="EnsemblBacteria" id="AEB47891">
        <property type="protein sequence ID" value="AEB47891"/>
        <property type="gene ID" value="VAB18032_04045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04045"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_0_11"/>
    <dbReference type="OMA" id="ETKHPTR"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="263" mass="28571" checksum="4B7B80BD6D926039" modified="2011-06-28" version="1">MGAPLVFAHRGASHDLPEHTLAAYLRALDEGADGLECDVRLTRDGHLVCVHDRRLERTSNGRGPVSTRTLAELESLDFGSWHPGCVPPDGDEVLDESHTRLLTLERLLEAVLAAGRPVRLLVETKHPSRHGGDVERRLVALLRRHGLAEPRPDAPVQVTVMSFSPLAVRRIRALAPALPTVLLLEVLPRWLRLGRLPFGAGIAGPGIGLVRARPMLVPALRAAGNQVYVWTVNEPNDLDLVLAAGVDGVITDRPAHTLARLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F499</accession>
    <name>F4F499_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736544.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04150"/>
    <dbReference type="EnsemblBacteria" id="AEB47912">
        <property type="protein sequence ID" value="AEB47912"/>
        <property type="gene ID" value="VAB18032_04150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04150"/>
    <dbReference type="eggNOG" id="ENOG503357V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048561_0_0_11"/>
    <dbReference type="OMA" id="DTVWASI"/>
    <dbReference type="OrthoDB" id="1396602at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="359" mass="38465" checksum="37FAA1D6D098C6F6" modified="2011-06-28" version="1">MTADHPSAPPGTPAHHESILLDEPSTADLRAKVTHAWREFARALADRLAALPPGAHVELTLDPTASGIDDAVYSVSVDVTEDGGLTARAVGNATLPQGYRLDRSAVADMVALGWSPPGVLEGSGDQFGLHCAVTESSRLAALISRTLRDIYGAPHPAFLVYLIVDAEGEPLAGAPLGTARSEFGTGREIETDLAQALADTADSGADTEVLELAERVRTVVSTMLKSDSDRVQVDSDGDINIRAGSAMVFVRVRDNPPLVDVFSPVLTEVEPTERLYVKLSELTNRMPIGRLYCADDTVWASIPVFGRNFQPTHLMLAVQVMTGLADELDDRLHGEFGGKRFFGEGDKPGRGEHRTGMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4E4</accession>
    <name>F4F4E4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08920"/>
    <dbReference type="EnsemblBacteria" id="AEB42902">
        <property type="protein sequence ID" value="AEB42902"/>
        <property type="gene ID" value="VAB18032_08920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08920"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_4_0_11"/>
    <dbReference type="OMA" id="MQLYAIA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="183" mass="20208" checksum="81547982A043A1B6" modified="2011-06-28" version="1">MSAAPLEPHVGLWTEDDYFAMGETHHRIELLDGSLIVSPAPSRRHQRVARRLANSIEATAEVNDLSVYDAINVRLGVDRVVIPDLVVTDADDEGTVLDASEVVLVGEIVSPGNAAADRVLKMQLYAIAQIPWYLLVEQDGDTHSLRLYRLDGGHYVEDQVAKAGETLTLAEPFRWQIDPATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4L1</accession>
    <name>F4F4L1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_15205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15205"/>
    <dbReference type="EnsemblBacteria" id="AEB44153">
        <property type="protein sequence ID" value="AEB44153"/>
        <property type="gene ID" value="VAB18032_15205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15205"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_11"/>
    <dbReference type="OMA" id="MLINEGQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="293"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="381" mass="41542" checksum="C80ADA1A36980039" modified="2011-06-28" version="1">MGLPLGIAFAARGLSVVLYDINADAVATVNSATLPFAEAGAAGPLAEAVAAGRLRATTDPAAVGTSEHLVVVVGTPVDEHLNPDLGAVPRALERCAEHLRDGQLVVLRSTVYPGVTALTEKLLVGRGVQADVAFCPERIAEGHAMTELFTLPQIVAARTPQSLTRAEKLFRHLTDRIVTLTPEEAELAKLFTNTWRYIKFATANQFWMMANDFGLDFARIRHAVAYEYPRAADLPMPGFAAGPCLFKDTMQLAAFNRNNFVLGHSAMLINEGLPLYLVSRLEDRFDLASSTVGILGMAFKGGSDDPRESLAYKLRKILALKTRETLCTDPYVIDERFVDLDEVLRRADLLVIAAPHEQYARLDTDKPVIDMWGLTGQGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4X1</accession>
    <name>F4F4X1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase ECF sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_21800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21800"/>
    <dbReference type="EnsemblBacteria" id="AEB45460">
        <property type="protein sequence ID" value="AEB45460"/>
        <property type="gene ID" value="VAB18032_21800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21800"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331469_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="138"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="206" mass="23824" checksum="3093800AEB4595C0" modified="2011-06-28" version="1">MPRQIGTDSNQGRDVGSVESRPKLTRAQVEQIEQLYLHEAEDLYRYAHSRSWIRAGDAHDLVQTTFHEAIRAWEKVEPLGVDERRRWLRQVLRNKAVDVWRKQNRVDLAVDVSELPPTSDDETAEHVALTIALANCWRAIEQMPPRRRMVAFLVWGQAWDVKRAAEHLGLAASTVRVHLREARLQLRASVGHLVPFIEDEKDWESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4X9</accession>
    <name>F4F4X9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734121.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21840"/>
    <dbReference type="EnsemblBacteria" id="AEB45468">
        <property type="protein sequence ID" value="AEB45468"/>
        <property type="gene ID" value="VAB18032_21840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21840"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044347_0_0_11"/>
    <dbReference type="OMA" id="FRLDLHR"/>
    <dbReference type="OrthoDB" id="624301at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="465" mass="50899" checksum="0C874431818F246D" modified="2011-06-28" version="1">MRSPTANADSRLSLWRRVREYAVPPSMIEAATARRHVGDWAGACAAARVDVDLDLRAVARIHGRELATRLRTDLRHLAPDLLRWHMPRIAPDGLLRPGVTISLTRYGPAEHDGAEAVHLVARTPPAWADAGQRISLALWAAGFPDRTDSSHPHPRPDRRFRLDLHRHLWDARRTDELRARSGLLPSASHNTVRPDPPWDALRERGYAVDRWAAEATLLLRQEGRTNGSVVVRLGPRRRLVVDVAAASTDVHPPAARLGRAARAGGVPGVPVLPDAATWTPPDVELLRHGLIEVDRLHPLVAAALAPGHRPRVTPTSPGPEAAPRLVACRGVWHRIGLVDGVLTPLDHDPAEIRREELLAALTGTPLACLQAIDEAHRSPQCLPDIRARLDHGDTAGALAAVEALLGPDALLRHGELRKELENAASRRITYGLFRAGLIGSGPATCSRDWQPKRARRSHPRHAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5M5</accession>
    <name>F4F5M5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LPXTG-motif cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732902.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15630"/>
    <dbReference type="EnsemblBacteria" id="AEB44238">
        <property type="protein sequence ID" value="AEB44238"/>
        <property type="gene ID" value="VAB18032_15630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15630"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052460_0_0_11"/>
    <dbReference type="OMA" id="CPDGGYP"/>
    <dbReference type="OrthoDB" id="1375732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313604" evidence="1">
        <location>
            <begin position="30"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="347" mass="35095" checksum="6DFE19A789AEA3B1" modified="2011-06-28" version="1">MVVRLSRHRLLALFCGVLAALTLATPAVAAPTQVGAVRPDAAAGWLARQLVDGERFETVFDGVAYPDQGLTLDAVFAFAAAGAADDFGAQALAWVTRPGVRDGYIGDGVTEAYAGATAKLALAVAVRGGDPTDVGGVDLIARLRSLQSPSGRFTDLSAWGDFSNAFSQSFAILALDRTTQGVPTAAAGWLAGTRCPDGGYPLLAAQPVCVSDVDATAVVVQALRAAGRSADAAAGLRWLVSVQRVDGGFASAGGVANANSTGLAAQALRDGGRPVAWLRARLFLAGLQVGCAAPVADRGAVDFDGGVFDPATATRATAQAVLGLTGTGYARLTTATASPGAPILRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5M6</accession>
    <name>F4F5M6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15635"/>
    <dbReference type="EnsemblBacteria" id="AEB44239">
        <property type="protein sequence ID" value="AEB44239"/>
        <property type="gene ID" value="VAB18032_15635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15635"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121780_0_0_11"/>
    <dbReference type="OMA" id="WGLAFVC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312713" evidence="1">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="148" mass="14594" checksum="B2E7CE7EAF704CC9" modified="2011-06-28" version="1">MLATAVVALGLIAVEPSPRAAQATTCTGTSGVTVVVDYGSLGGGVQVACALGDPATGLAALQGAGFTVTGTQRWGLGFVCRINGQPTAATEPCINTPPASAYWSYWHASGSGAAWTYSTLGATSYNPAPGTVEGWSFGAGVAPSITAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5M9</accession>
    <name>F4F5M9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_15650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15650"/>
    <dbReference type="EnsemblBacteria" id="AEB44242">
        <property type="protein sequence ID" value="AEB44242"/>
        <property type="gene ID" value="VAB18032_15650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15650"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033425_0_0_11"/>
    <dbReference type="OMA" id="AWWLWAL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="414" mass="43096" checksum="A1F094797FDC5797" modified="2011-06-28" version="1">MTDRAVVDSGPPARVSAWSGVRSVRAGRLPRSLHPGAWWCWALGLATAASHTTNPLPLAMIVAAAALVVVRRRGNAPWALAFRMYLVLGAVIVAMRVLFRLVFGGGQGDHVLLHLPEIPLPAWAAGIRLFGPVAAEQLLGGFYDGLRLATMLICLGAANALANPKRLLKAVPGALYAVSTAVVVALSVAPQLVESVLRVRRARRLRGAAGHGLRALRGIALPVLADALDRSLALAAAMDSRGYGRTAAVPAGQRALTGALVLAGLVGVCVGTYGLLDATVPGYLGLPMLLAGLATAVAGMLLAGRQVRRSRYRPDRWRLAELAVAGCGLATAAVMTMAGTVDPERLYPPVSPLTWPELTPLLVLAVLVAVAPAWLAPPAPTANPAPRPLPVPPAATGRTDHTSPRDTAQPEAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Z8</accession>
    <name>F4F5Z8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">McnC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_22285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734210.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22285"/>
    <dbReference type="EnsemblBacteria" id="AEB45557">
        <property type="protein sequence ID" value="AEB45557"/>
        <property type="gene ID" value="VAB18032_22285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22285"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_4_11"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="801"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="882" mass="95242" checksum="3F21B7DEDF3CAA54" modified="2011-06-28" version="1">MTMESDTEALRRRLDHLPPDRRRALERVLRARAEPPRSTAPLAPRPDPDAPAPLSYAQERLWYLEQLYQRRDIFAFPTASRLHGPLDLAALRSACADLAARHDSLRTIVTTIDGRPAQQILPVGTVDFALVDLTGTDPATCAERASADALAGFDLATQPPLRIRLYRLADDDHVLVVNQHVAVADMPSRAILLRDLWNRYEAAAYGTAPPLPTLPIQYADFAVWQRDRLDGQRLDRLLDYWQQHLRDAPHKLAIPTDRPRPARHEGAGRFYYDTAPDGLGERVHEAARAWRTTPSVLLLACYRLLLWQYSSQEDIVIGVPKSERAHPETEHLIGYFVNVLPLRSQVRDTDTARQVIAREHAHALAAYARQELPYERVVRDVNPVREAGVPPLYQVSYSYLADDGTGLPLAPTGLRGEPFPLRSEGTEYDLGVNVLHGAQLGAQWPYNDDIFDESTIVTLAGQFWALVAAVVDAVDTPVTALPVVHEAPTAPTTAAGDGARRTPIDSPLSTVPAAAAALGPIGRLLSTVPPGSALADVDAALAEATGAELIRVPDDGSDLTALVDRLRPGLLSATVPLLARLPAGWRAPQGCALLAVGDLHRAAAARLAERADVVWYGCLRTAGGLATVGRLSVGPHRVDAGRPLAPLRAWTAHPSGRPLPQGAFGTLHLGTTDAAEAGEPTRWYARIRADGRVELVGPADERTVLRGVPLHPGEITDLLVECPGVRDATTLTTADGTLHAYLVLDGTTDASQVRQRLAQRLPGFAVPGLTVLPALPYTADGYVDRAALPAPTADGRTGGRAPSGPVEQVVVDAWRDLLGRAPTQVDDNFFDLGGHSLMLQQLSARLSEAFGGTVPLIELLEHPTVAQQAQLVTELGLAEEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F608</accession>
    <name>F4F608_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22335"/>
    <dbReference type="EnsemblBacteria" id="AEB45567">
        <property type="protein sequence ID" value="AEB45567"/>
        <property type="gene ID" value="VAB18032_22335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22335"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_13_11"/>
    <dbReference type="OMA" id="PGCYVFM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="13532" checksum="91BA61C4FD3F076D" modified="2011-06-28" version="1">MDRHYTEALDLAAVAAVAGISKYHFHRLFTITYGLSPAAYLSQRRIERAQDLLRATNLTVTEVCYAVGFASLGSFSSRFRELVGESPSEFQRRWAQAGTPHIPGCFVFMWGLAERRDDAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F687</accession>
    <name>F4F687_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28841"/>
    <dbReference type="EnsemblBacteria" id="AEB46839">
        <property type="protein sequence ID" value="AEB46839"/>
        <property type="gene ID" value="VAB18032_28841"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28841"/>
    <dbReference type="eggNOG" id="COG1877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010399_3_0_11"/>
    <dbReference type="OMA" id="GGFHLCA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="261"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="496"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="868" mass="94354" checksum="1101F8104BEF82F8" modified="2011-06-28" version="1">MSAPSSEIIMPTAGTMDRELASAIGRIARVPQLLIACDYDGTLAPIVEDPSKAVPLPESVAAVRALAALPQTTVAVVSGRALRDLAALSRLPSEVHLVGSHGSEFDIGFVERLSPELIEVRKRLRDALREIAAAHPGVRLERKPASVAVHTRGVEPQVAAAAIEAVRNGPATWPDVTVTQGKEVIELSVVATHKGTAVDQLRTQLSASAVLFIGDDVTDENAFGNLSGPDVGIKIGPGETKAGYRVAEPIEAARVLGLLLETRRHWLFGERAVPIERHSMLANGRTVALLTPDAKVTWLCNPKPDSAAIFADLVGGSPAGHFSVAPERGGIPLGQRYRSGTMTVETRWSGLTVTDWLDKPDPRTTPDGPAIISGDSTLIRVLTGTGRARLEFAPRPEFAQVAVQLQPLADGLLVLGSNEPIALYSPGVQWEVGNDGGYESAKAVVDLSALGGQVVLELRFGTHSLEHHRLPIHERQAAAERPWKDWVASLRLPTTARDLVARSALTLRGLCHEATGSILAAATTSLPEELGGVRNWDYRYCWLRDAAMTARALVDLGSIAEAEAFLRWVDGCVERTGGHPERLHPLYTVDGYELGAEAVIDTLPGYAGSRPVRVGNLANHQLQLDVFGPIADLIAATADVRGSVRAEEWRVLENMVEAVRRRWHEPDHGIWEARLPPRHHIFSKVMCWMTVDRALHVVRQHGGEDRPEWVELRDRIGANVLEYGWHEEAAAYSVAYGDEDMDASSLWIGLSGLLAGDDPRFLSTVLKIEADLRSGPVVYRYHWDDGLPGREGGFHICTAWLIEAYLRTGRRTDAEELFLQMIDTAGPTGLLPEQYDPLAERGLGNHPQAYSHLGVIRCALLLDNMLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6D1</accession>
    <name>F4F6D1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">prfB</name>
        <name evidence="7" type="ordered locus">VAB18032_09795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731748.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09795"/>
    <dbReference type="EnsemblBacteria" id="AEB43077">
        <property type="protein sequence ID" value="AEB43077"/>
        <property type="gene ID" value="VAB18032_09795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09795"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_6_0_11"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="69"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="373" mass="41178" checksum="E935CBF43A004E22" modified="2011-06-28" version="1">MTAADYADQLKDLDATLRNIEAVLDLDRLRADKARLEQEASAPDLWDDQARAQQVTSQLSYVNGEIEKLGSLRSRIDDANVLLELAEAEADSGVLSEVESEITGLAKAIQEMEVRTLLSGEYDSREALVAIRAGAGGVDAADFAEMLLRMYLRWAERHGYPTEVYETSYAEEAGLKSATFTVKVPYAYGTLSVESGTHRLVRISPFDNQGRRQTSFAGVEVLPVVEQTDSIDIPENEMRIDVYRSSGPGGQSVNTTDSAVRITHIPTGIVVTCQNEKSQLQNKASALRVLQARLLERKRQEEQAKMAGLKTDAAGSWGDQMRSYVLHPYQMVKDLRTEQETGNPSAVFDGDLDSFIEAGIRWRKQQQLAGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6K1</accession>
    <name>F4F6K1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732989.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16115"/>
    <dbReference type="EnsemblBacteria" id="AEB44329">
        <property type="protein sequence ID" value="AEB44329"/>
        <property type="gene ID" value="VAB18032_16115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16115"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050853_0_0_11"/>
    <dbReference type="OMA" id="LRHTESW"/>
    <dbReference type="OrthoDB" id="1489314at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="309" mass="34065" checksum="B558F1DC0FD5648A" modified="2011-06-28" version="1">MGLEALRHSLTAAIDVDHDEWPDIVAAYGRCYYQQPHDQVMTQLGRDLAVLQHQIAVDQGERRPLLLKAAGQLSVIIALGLVASGQAIAARRWWHTARRVADESADPDAQIMVRAWDVVNGSYDGRPAVQVVAVSDEVLPLLDGRASAATCGLLAGLAQALSLAGRHAEAVATVQQLARMAEQLPATVVDDVESLWGWPEHRLRHTESWVYTHAADYRRAGEAQDRALALYPASQIRLRTQVELHRAAALIRTGHVPDGLRLAADLLDRLPTSQHNELVRSVARQVVVAVPDSERRQSSYRELLERVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6P5</accession>
    <name>F4F6P5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_16335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733033.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16335"/>
    <dbReference type="EnsemblBacteria" id="AEB44373">
        <property type="protein sequence ID" value="AEB44373"/>
        <property type="gene ID" value="VAB18032_16335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16335"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="LMPWRSA"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="27187" checksum="28C874A743D2DA72" modified="2011-06-28" version="1">MPSAESGHTAAITVTDVEHRYGEVVALGPIDLTVPPGEFLVLVGASGCGKSTLLRLIAGFEQPTTGTVLTDGVPPIPGRSAGLVFQQPRLFPWKTVGGNIELALRYAGQPTDGVDALLNRVGLHDVAKRRTWQISGGQQQRVAIARALAADRPLLLLDEPFAALDALTRERLQEDLRSVSTAPGRTSIFVTHSVDEAVFLGSRVVVLSPRPGRIVLDLPIHLPRTGITPDDLRGLPDYAALRAEIGHAVRSEGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Q3</accession>
    <name>F4F6Q3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H-depedent FMN-reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NAD(P)H-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">abyZ</name>
        <name evidence="2" type="ordered locus">VAB18032_16375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733041.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16375"/>
    <dbReference type="EnsemblBacteria" id="AEB44381">
        <property type="protein sequence ID" value="AEB44381"/>
        <property type="gene ID" value="VAB18032_16375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16375"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_3_0_11"/>
    <dbReference type="OMA" id="DVEVCHW"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008752">
        <property type="term" value="F:FMN reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020048">
        <property type="entry name" value="NADPH-dep_FMN_reduc_SsuE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03567">
        <property type="entry name" value="FMN_reduc_SsuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEK75514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="19704" checksum="D1A0B248EAF34BA3" modified="2011-06-28" version="1">MPTVLSVSGSPSATSRTAGLLRHLDRQLVADGHEVIPLDVRTLPAHVLVGADPRHPAITGVAALVAEADGLVIGTPIYKAAYSGLLKCLFDLLPQYALAGKTVLPLATGGSRAHVLAIDYALRPVLTAMGAGHVLPGWFTLDTDLVVGDDGTLVVAPAAADALCEVVDRFAAALHRAVTSAPPDGTGRPGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Z7</accession>
    <name>F4F6Z7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735510.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46861">
        <property type="protein sequence ID" value="AEB46861"/>
        <property type="gene ID" value="VAB18032_28951"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28951"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_4_2_11"/>
    <dbReference type="OMA" id="VISTADW"/>
    <dbReference type="OrthoDB" id="2041259at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="80" mass="8609" checksum="9A4376C3605586A4" modified="2011-06-28" version="1">MAEPLAAKNDRPRFRSVADTAAILGMSEVTLYRAIHAGQFPAIKVRGRFVIPARAIDDMEASALTYGLVDASNHTLRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F706</accession>
    <name>F4F706_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaB domain-containing protein helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_28996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735519.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28996"/>
    <dbReference type="EnsemblBacteria" id="AEB46870">
        <property type="protein sequence ID" value="AEB46870"/>
        <property type="gene ID" value="VAB18032_28996"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28996"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020866_3_0_11"/>
    <dbReference type="OMA" id="VFLKGHA"/>
    <dbReference type="OrthoDB" id="1439550at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025048">
        <property type="entry name" value="DUF3987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13148">
        <property type="entry name" value="DUF3987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="651" mass="68520" checksum="5EE364D0F5B4048D" modified="2011-06-28" version="1">MTRPPAHDHAAEQAVIGAALLNPSVVADLAPTLAPADFHRPAHGRLWETLCAMHATGEPLDPIALAAHLAATGDLAKVGGASYLHTLIAAVPITANAGHYARIVTDHARRRQVADLGTYFAEKADQGADVTDVIATGRAMLDHAATGTQWAPLIPLGDRRHLPEFPAYVLPGWVAEQIYAVAEFTQTPVDLAGCIALAALSTAAGGRAEVEVRGSWREPTNLFTVVVLPPGSRKSAVFAAMTGPLLAAEKTLVERVKPAIVEAELAARVAGKTAEKAAIAAANADTSGRDTLLAEATAAAMNADAVTVPVLPQLIADDVTSEEAASLLAEQGGRLAVLSPEGGIFATIAGRYSGTPNLEVFLKGHAGDMLRVNRRSRAPEHVEHPALTLGLAVQPDVLRDIADMPGFRGKGLLARILFSLPENTVGRRKIGADPVPEPIATAYTANLGALVATLAEWTDPAVLPLTSEANERVLDIERAVEPRLAPGGAWGHVVDWGSKYTGAVVRIAGLIHLAEHLRDGWGKPVTAETVERAALLGEYFAAHALAAFDDMGTDKSTRYARLVLAWIERTGSTTFTKKELYRAVRSQIPTAADLDPVLSLLEVHGYLRQLDPPARTGAGRPPSPAFLVHPDVNQATGTVHALPATTGRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F710</accession>
    <name>F4F710_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735523.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29016"/>
    <dbReference type="EnsemblBacteria" id="AEB46874">
        <property type="protein sequence ID" value="AEB46874"/>
        <property type="gene ID" value="VAB18032_29016"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29016"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_11"/>
    <dbReference type="OMA" id="YCSGTWV"/>
    <dbReference type="OrthoDB" id="1546902at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="31647" checksum="EC3C52E0E3A76DFE" modified="2011-06-28" version="1">MSEFEVQVGAGIHPPAKVLIIGAAGYVGTHTARAFVQSGYQVTGLQRPGGTKVSARYPTVPGDLTDPASLTRAAQGFDLVVNLGPPLDEERDLAAIDALLASGVPLIHTSGSDVSGEGYRAEDTLPTPHPFVGWRDTVERRAVEGGGIVVRPGLIYGNGGGVVGDMWIPLRDRVGAGVYIGEPGVRWAAVHVEDLAWLYVAMAAKAAPGTYWHGVAESIEVDAIADVIGGGKTISWPLDEEPPAEIAVLAGLFRLDQEVSAVKTRHLLGWSPAYPSIVTALRHELRREPMTDWRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F715</accession>
    <name>F4F715_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29041"/>
    <dbReference type="EnsemblBacteria" id="AEB46879">
        <property type="protein sequence ID" value="AEB46879"/>
        <property type="gene ID" value="VAB18032_29041"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29041"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_2_11"/>
    <dbReference type="OMA" id="TFIMNGH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="44434" checksum="C8C04A090F77FA86" modified="2011-06-28" version="1">MDRNGEDIHAETEEIRKQGPVAQVELPGGVLAWSVTSHDLVKRVLSDDRFAKDPRQHWPAFINGEIPPDWPMITWVVMDNMTTRDDPDHERLRRVISQGFSARRVEAARPLIEGIAKRLLDNLEQVPAGTVVDLKKAYCYPLPASVVCDLFGVPEEARADALKGGEVNVSTNISGEEAEANVEQWHKAMEDLVAEKHARPGDDLTSLLIARRSVDDEILTDEEMVGTLHLMLGAGSETLMNLLSHAILNLLTHPDQLELVRSGQVGWDAVIEETLRVQSPVAQLPFRFATEDIQLGDVLIETGDPVMIGFAGVGRDPAVHGETRAEFDITRADKTHLSFGHGVHFCLGAPLARLEAAIALPAVFERFPDMRLAVAPEELKPQGTFIMNGHAALPVYLKAPVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7A5</accession>
    <name>F4F7A5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trka domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731834.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10225"/>
    <dbReference type="EnsemblBacteria" id="AEB43163">
        <property type="protein sequence ID" value="AEB43163"/>
        <property type="gene ID" value="VAB18032_10225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10225"/>
    <dbReference type="eggNOG" id="COG2910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_3_1_11"/>
    <dbReference type="OMA" id="DWTFLSP"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="22660" checksum="538913CD2660835B" modified="2011-06-28" version="1">MSDIVVFGAGGTAGSRIVTEAFNRGHRVVAAVRRPEATTYLPAGVRVVTGDATSERSVRELAPAADALVVAIGGGDRTLWPDAARALIAGLRQMPAAPRIIHVGGGATLLSPSGRRLLDEPDFPAQYRDSALGQAEALDVYRSDADGVSWTYVSPPPLEFHPGERTGRYRIGTDHPVTDTSGRCALSYEDLAVAVIDEIENSQFPNSRFTVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7G6</accession>
    <name>F4F7G6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">orfP</name>
        <name evidence="7" type="ordered locus">VAB18032_16505</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733065.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16505"/>
    <dbReference type="EnsemblBacteria" id="AEB44405">
        <property type="protein sequence ID" value="AEB44405"/>
        <property type="gene ID" value="VAB18032_16505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16505"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811143_0_0_11"/>
    <dbReference type="OMA" id="LNPGHTE"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEK75490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="360" mass="39172" checksum="2FDE972AFF77ED50" modified="2011-06-28" version="1">MTELDRAFDAVPAPIYTHHERHGETVHRSAPESIRRELAALQVRAGDRVLEIGTGSGYSGALLAHLCCPDGQVTSIDISDELVRRAAAIHAERGVTSVDCHVGDGLAGYPAAAPFHRAVSWCAPPRLPRAWTQQVVNGGRIVACLPITALPSTTLIATITVAAGKPRIEALAGGGYAQSTPVAVDDALTVPGRWVDYCDRQPDPSWIGICWRSADDAQHTGARSALGQLLHPGYTDTYRQMEPHWRSWYTWTSALGDPQLSLVSLRNEIRGLGHTTPSSAAVILTDGRVIADRPDSPSLRSLRTWLQRWEHVGRPAPESFARTLVPHDCPDLAGWDLQVGHGSVTTDRQPPRRVDEPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7I6</accession>
    <name>F4F7I6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_16605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16605"/>
    <dbReference type="EnsemblBacteria" id="AEB44425">
        <property type="protein sequence ID" value="AEB44425"/>
        <property type="gene ID" value="VAB18032_16605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16605"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289828_0_0_11"/>
    <dbReference type="OMA" id="PVDAWWV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309142" description="FtsX domain-containing protein" evidence="7">
        <location>
            <begin position="16"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="925"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1023"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="952"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1057" mass="107320" checksum="D2738EEFCB7ECDE6" modified="2011-06-28" version="1">MTRAMLRLVRRRARAQWPLLAALVGVVTVGATLLGTCTLLSTRTTERALEVAMARAAPAAVDVTVYTGTVEGPDAQSVDADTRAVLAATLAPFPVTTTARASTVLRALPAALAPGTTVAAQAYLSGLDDLPTRAELVTGRWPRERGDAVVLESTAQLIGLTPGRRVRLGAELAHDPVPAIDVTVVGVVRPLPGRGWDRDPLAAAGSATGYHDGRFQQPVNAYGPFLVDLADLLTTGATIGRMEVTAHPDLSHAHRRDLQTVADAVRGADRRLAGTLGDRVRLARVASDLPLTLRAAGDQRHATAALVLAIAVLGGVLTATALVLAGRLTAGIRADETALRTALGTSRRQLAATATLDGGFVAAVAVVLAIPASSALHAGLTHLPPLDDADLTTTPTVTAAQVLAIVAGALVLAAVLTVLAIRPGPAPGDRRTRRELLARSGADLILAALAATAWWQLYAQPTTASPRADTVRILAPALLLTTGAALALRVVLPALRGTDRLAYRTRGLALTLAAAEAARRPQAVAAGLLVALACAAATFGLAFDTTWHQSQRDQAALAVGTDLAVSLDATPVPGDGANLAAATAGTVSPVLDRGTAVGQWLGTAGDAPRLVAVDTTRADALLRGRLDHDRTWTDVGAALAPPTPVTGLPVAAGAPLVLSGTATGPIPLTVTPRLLLQDATGLRTPCTGPPVPLDGREHRLPACATADGLHLVAVSLPVTAGPDATVGSPIGIAVTLTVPPTASADGSPWTATSAPPIPTKLRDPTVVLSATATGTALQMAATVDLGDADAARTLVATAFPDPGPVPVAVGTRFATAVGADIGSQLSITVGTTPVPIVVTEVVPAVPSAPGAAAVLADLDTLSRARAVTGDLTFPVDAWWVGHPTDPGAAERATALHLGTVTTRDAETARLTSGPLHAALPAALRLVVPASALLLLAGIVAHVTCDLQVRAVEVARLRGLGMTRRGIRAVLLGQHAVILLPLLAAGTAVGALATRLVAPLLVRSDTGAAPIPAAQPHWPWPAEAALLAVLLAGCLLTVAAVVSVQVRRADAAHLRVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7J7</accession>
    <name>F4F7J7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ordered locus">VAB18032_16660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013287204.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16660"/>
    <dbReference type="EnsemblBacteria" id="AEB44436">
        <property type="protein sequence ID" value="AEB44436"/>
        <property type="gene ID" value="VAB18032_16660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16660"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_1_1_11"/>
    <dbReference type="OMA" id="GTGFYYT"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="6643" checksum="B0D8E9C9CCA7F206" modified="2011-06-28" version="1">MARQTDVRPIVRLRSTAGTGYTYVTRKNRRNDPDRLVLRKYDPVVRRHVEFREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7M0</accession>
    <name>F4F7M0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733116.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16775"/>
    <dbReference type="EnsemblBacteria" id="AEB44459">
        <property type="protein sequence ID" value="AEB44459"/>
        <property type="gene ID" value="VAB18032_16775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16775"/>
    <dbReference type="eggNOG" id="ENOG5033RJG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096814_0_0_11"/>
    <dbReference type="OMA" id="RKQAFFG"/>
    <dbReference type="OrthoDB" id="1318943at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="254" mass="27425" checksum="342EAB8B9CC3B64A" modified="2011-06-28" version="1">MGDLLINLLASVIAGTAVWLTGFLLRRRKLNRARAFFGLTAGASCLLVVSRHASSPREFSVHRRDVAALVELATIARECGAHADRVGENQPTGEIGRLTEFCVGGPGASPRSATHVRAILRGVTYEVFDEDKRRMSFTVGGTDYVYSPETSYVLLARFWGPTGGRPVFFIGGLTAGSNLAGARYLTRHHSDLARTFGADRPFALVLRIIEPAAYGTDFTELIADVTDIAFQPPAHSDGERTPQPPEMPATHASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7W3</accession>
    <name>F4F7W3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29336"/>
    <dbReference type="EnsemblBacteria" id="AEB46938">
        <property type="protein sequence ID" value="AEB46938"/>
        <property type="gene ID" value="VAB18032_29336"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29336"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_3_0_11"/>
    <dbReference type="OMA" id="QWYDNEA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="14231" checksum="25A3DC3BFB7A7300" modified="2011-06-28" version="1">MPPMRTDLPGHRHEWLDDDAGPVVRPYTLTGGRVRSCADGFDLVAYVLASPNPDLGAYPELHPEHRLLVELAGRGTPVVELAADLDLAVGVVRVLLGDLLTRGLVAVQQPPRATYLPDNDILKAVVDGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7W9</accession>
    <name>F4F7W9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_29366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29366"/>
    <dbReference type="EnsemblBacteria" id="AEB46944">
        <property type="protein sequence ID" value="AEB46944"/>
        <property type="gene ID" value="VAB18032_29366"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29366"/>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015488_3_1_11"/>
    <dbReference type="OMA" id="RYDRRIH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM2" evidence="10">
        <location>
            <begin position="57"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="615" mass="65169" checksum="36C0F2105D7B64EF" modified="2011-06-28" version="1">MQGALGPRAGPYADPVSPKEISGMNLWRKLSGPRRAVALAGASALVAGGLVTLPVSAAYAATQCDVAYTTNDWPGGFTANITIRNIGDPINGWTLGFTFPDGNQRVQNGWSARWSQSGRNVTAQNESYNGNLSTGGTASIGFNGAWSGSNPRPTSFTINGVACNGGNPPPTSPPPTSPPPTSPPPTSPPPTSPPPGTKVDNPYLNAKGYVNPEWKARAESVPGGNRVSNISTAVWIDRIAAIEGTEDSQSNGPMGVRDHLDEAVRQGADYIQFVIYNLPGRDCAALASNGELGPNELPKYKAEYIDPIAAIMRDTKYRNLRIINVIEVDSLPNLVTNTSNNPGGTVMCDTVKANGAYVNGVGYALATLGSIPNVYNYVDAGHHGWLGWDSNFTPSAQVLKQAATASGSTVNHVHGFITNTANYSALIEPYAKVDATVNGQTVRQAKWIDWNWYNDEQSFAQAFRQELIRQGFPSNIGMLIDTSRNGWGGPNRPTAAGPTTSVDAFIDGGRVDRRIHKGNWCNQAGAGMGERPKAAPATGIDAYVWAKPPGESDGSSREIPNNDGKGFDRMCDPTYTGNDRNGNSRSGALPDAPISGAWFSAQFAELMANAYPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7X4</accession>
    <name>F4F7X4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735597.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29391"/>
    <dbReference type="EnsemblBacteria" id="AEB46949">
        <property type="protein sequence ID" value="AEB46949"/>
        <property type="gene ID" value="VAB18032_29391"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29391"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025328_0_0_11"/>
    <dbReference type="OMA" id="DMATPNT"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312768" evidence="2">
        <location>
            <begin position="32"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="158"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="373"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="649" mass="68864" checksum="F9D9C6D3C17359CA" modified="2011-06-28" version="1">MHRSHRHRHNWSRLAAVVAGLVASAGLVACSGEDGPERTVDAFLKGWRTGELNTIGFVDPTGAKVPAATVAQEIRELSGELVDAPLTLTRQGDPTVVQSTATATVRLEWTLPDETSWAYDRPVRLTQGRDDHWQVIWEPQIVQEKLTRGDRLGLQRVRAPRATVLDAAGEPIVAPRDVVRVGLQPSEVTDVKAMTRELDAAFRAIRPAITPPVDLSDLPKRLDEAKPDAFVEVVTLRDEAYRQIRSRIYDLPGTKFQSDKLDLAPTREFARAVLGTVDPAHAEDLAKHPDRYAPGDLVGHGGLQGRWDDHLRGAPGFTVIIKRPKQDGTLEPTGTEVFQREPQPGKPVKTTLDVATQKAADQALRGERRRSALVAVRISDGAVLAAANGPGAAGENLAFTAQVPPGSTFKMVSALGLVERDAVTPDTDVDCPKTLVVDGRSFKNSNNFELGEVPFRTNFAKSCNTAFAALAPQLGADGLAATGRSLGLEGQWQVGLDAFTGKVSAGGGATEQAAAAIGQGTTVVSPLAMAAATAAVAKGAFTAPKLVLDPAPEPAGEPGPELKPEAVTAVREMMRAVITDGTGTALKDVPGEPVHGKTGTAEYDNNPKNTHAWFVGWQGDIAFAVFVEKGGSGSGTAAPIAERFLRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F822</accession>
    <name>F4F822_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735645.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29631"/>
    <dbReference type="EnsemblBacteria" id="AEB46997">
        <property type="protein sequence ID" value="AEB46997"/>
        <property type="gene ID" value="VAB18032_29631"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29631"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_11_11"/>
    <dbReference type="OMA" id="YWLYFVT"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="485" mass="52658" checksum="442DD26F711F2067" modified="2011-06-28" version="1">MRCLVTGATGYIGGRLAPRLLAQGYDVRCLARRAGRLRDVPWAGQVEIAEADLSRPETLPAAFDGVDVAYYLVHSLGQAGFEATDRQAATNFATAARTAGVRRIVYLGGPEPAADDPATSAHLRSRSEVGRILQASGVPTVVLRAAVIIGSGSASFEMLRYLTERLPVMVTPRWVANRIQPIAVRDVLHYLVGCASLPAEVNRGFDIAGPDVLTFGEMMQRYARVAGLPRRLLLPVRPLTPTLSSYWVGLVTPVPNALARPLVASLIHEAVAHEHDIAAYLPDPPGGLTGFDEAVELALAKVRDAQVETCWSTAAGPNAPAEPLPSDPDWSGGTAYTDVRERPVAASPEALWQVIEGVGGEHGWYSFPLAWSVRGWLDKLVGGVGLRRGRRHPHQLRVGEALDFWRVEEIVPGELLRLRAEMRLPGRAWLELRVQRGDDGGVRYRQRAVFLPHGLVGHAYWAAVAPFHALVFGGMARNITGRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F867</accession>
    <name>F4F867_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10550"/>
    <dbReference type="EnsemblBacteria" id="AEB43228">
        <property type="protein sequence ID" value="AEB43228"/>
        <property type="gene ID" value="VAB18032_10550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10550"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_986291_0_0_11"/>
    <dbReference type="OMA" id="FDARFEP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="299" mass="31596" checksum="91612F670BCB900D" modified="2011-06-28" version="1">MRFVWTLAGMLLLAVGITALVGAAALGLLTGHADPGGTYAARFETVQTTGHAVVVTDLDELVRQEVPLAGVGEARMRLDARTHDGPAFVGLAPADEVRRWLAGAPYAVVERMALARGPLPVRLTPVTPSADERPTVPAGPGAQTFWTRAGNGTLEWTPDELAGQRLSLVLMRTDGRADLTLELRAELRPGWLAPATWGSLTAGMLLVIVAALLLLRPVRPREVIIVVEPDQVPILAGRLGISSLSGLGTPPPNRFAERQLVAVGSTLPATRAIAPVPRPQTLADLPAPHHPLRPPAPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F871</accession>
    <name>F4F871_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptide ABC transporter periplasmic component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10570"/>
    <dbReference type="EnsemblBacteria" id="AEB43232">
        <property type="protein sequence ID" value="AEB43232"/>
        <property type="gene ID" value="VAB18032_10570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10570"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_4_11"/>
    <dbReference type="OMA" id="GIKHEWS"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307500" evidence="1">
        <location>
            <begin position="33"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="83"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="538" mass="59017" checksum="F5E86377A1714232" modified="2011-06-28" version="1">MKGRWRLAVALGVVATLGVSGCGLNEDNNSSSSNSSSDTVLRIGTTTDVSNFNPLQSLSKTDSWILNAMYPHLLRIDENAKKSPELAKEYRYEDDGKTAVFVLRDDFKWSDGKPVVADDVKFSAEKIMEYKLGNVAAKLTWVESIEAPDATTVKFKLSQPYAPFAEGVGFWMAIVPKHIFEPAGDLSKFANDSNWVGAGPFVLDSVTKGQRYVMKRNEHYPLAPGGKAAVSQVEYRVYPDVNTMMLALRNGDIDLMGTPVPVSAAKTFEGDDKIKLQKVGALGFAHLTYNMKNKYLADQQVRQALSMAVDTKAIISAVLQGDGQQMAGPISPIFSEYDNTELQPYPFDPEGAKAKLSAAGYKDANNDGFFDELSFGVACDQSNANITRVVQLFRESAAKAGIKLENECVERNTFLTRTKNGEYDIDASQWGVFDNPMDQLRSTYLSSNPGGINYNLLESAEMDALINDAAGTTDAEEFKTKIKNIDKVVHEQAYLTPLYVENFQFAYNASKFTGFVASPSDLLGMVTAYSLAQVTPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8F5</accession>
    <name>F4F8F5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44500">
        <property type="protein sequence ID" value="AEB44500"/>
        <property type="gene ID" value="VAB18032_16980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16980"/>
    <dbReference type="HOGENOM" id="CLU_3391018_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="32" mass="3365" checksum="ECAE82B735B39CC8" modified="2011-06-28" version="1">MLDTDGMPSADRTAHRIHDGRSTAAATRAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8L8</accession>
    <name>F4F8L8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_23315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734413.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23315"/>
    <dbReference type="EnsemblBacteria" id="AEB45761">
        <property type="protein sequence ID" value="AEB45761"/>
        <property type="gene ID" value="VAB18032_23315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23315"/>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_4_0_11"/>
    <dbReference type="OrthoDB" id="1508841at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="20846" checksum="0AE650BD3A545DCD" modified="2011-06-28" version="1">MSDDQEAAGAVNFIFEAGVLKRAARTGWWFAGVKHPESIAEHSFRTALIGMMLAAMEGADPARVSMLCVLHDTQETRITDIPHIAKRYLTAVPNTTVTADQVAGCPPPVADLINAAVAEYEAGETLEAIVARDADKLECLVQAVEYRHQGIDTVQRWIDSSRAALKTATAHRLADAALAGQPIAWLTPPPLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8S9</accession>
    <name>F4F8S9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734474.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23620"/>
    <dbReference type="EnsemblBacteria" id="AEB45822">
        <property type="protein sequence ID" value="AEB45822"/>
        <property type="gene ID" value="VAB18032_23620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23620"/>
    <dbReference type="eggNOG" id="ENOG50328HT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179056_2_2_11"/>
    <dbReference type="OMA" id="KKEMTIQ"/>
    <dbReference type="OrthoDB" id="2065458at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018691">
        <property type="entry name" value="DUF2188"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09954">
        <property type="entry name" value="DUF2188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="73" mass="7932" checksum="377B89CBEE5B9741" modified="2011-06-28" version="1">MTRTEYHVVPDGGGWKVEQGGTTVGTYDTKHRAVEAGREAAHGSEPSQLVVHTADGRIETEYTYQDDPYPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8W2</accession>
    <name>F4F8W2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thrombospondin type 3 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47042">
        <property type="protein sequence ID" value="AEB47042"/>
        <property type="gene ID" value="VAB18032_29856"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29856"/>
    <dbReference type="eggNOG" id="ENOG5031QXP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079037_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="339" mass="34768" checksum="AC902ECFD2183F1E" modified="2011-06-28" version="1">MRFPSLSRRAEPATTLDEDAERGATVATDTRPTDRNDGAYRSSSAAPTTERPTNPATAERPTNPAAARPADTAATRAANPAAADRSGTAERASDRAATGGVAGAAPVDSTDRPATERAAARAATARSGVDGSRRARATTPVPPTGRTSPTSTTTRNDTAATPTSTTTPTEATARNGATATGVIAGSGVTDRTRADDLERAPERDPLDGERDGSVERTGGRESADEAQVVAGRRPRPSLLATLGLIVGVAGLLFVLTGTLAGYGIGIGALGAVFAVLGLIATRRRHVAGKPDALLGIAFGLGAVVLGVLAMTGQYDWPNTDGDTVTRLREWLDSQFVDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F902</accession>
    <name>F4F902_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_30056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30056"/>
    <dbReference type="EnsemblBacteria" id="AEB47082">
        <property type="protein sequence ID" value="AEB47082"/>
        <property type="gene ID" value="VAB18032_30056"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30056"/>
    <dbReference type="eggNOG" id="COG5305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024191_0_0_11"/>
    <dbReference type="OMA" id="ERWQFNL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="81"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB47082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="523" mass="55367" checksum="8D7B4DDD4F3A7DB5" modified="2011-06-28" version="1">MGDLSGRSIPTAGTGVRLTGWRLRSLPVWLVPAALTMFVTLVGLDAAQPWRDELATWSAASRGVAGLFRLAGTIDAATGPYYLFMHYWLLVAGDTVAALRLPSALAMTAAAGLTAVLGQRLWNTRVGTLSGLLFAVLPATARYGQEARPYALATALALLSTLLLVDALRRPGRGRWVAYAVATAALGLTHLIALTLVVAHAVVVFTYRPRTAAPTGAGHSPTDHAPADHPPAHYAPAGRGRAGRLGPLGPFLLALVPTAVLVTPLALRAREQRERQLDWVDTARLGDLAALPGGLAQTAAVGGLLVALAVLGAGRLGRRASLPVACLLLPVLLLFAAGLVVPLWVPRYLIFVVPFGCLLAGAALASARFRVALVVVSLAGLLGLPDHVALRRTHEWPRTATVDYRGAAQIIAAGQRAGDAVVYHPRDSWLFLDLGVRYHLHEQTPRDALLAEGQQHRGDLWAAECDRPADCLTDVHRVWLVVAGRGDGPLDTVPGAKGDALRAAYSVERIWPRPGLTVALLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F972</accession>
    <name>F4F972_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_04870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730774.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04870"/>
    <dbReference type="EnsemblBacteria" id="AEB42100">
        <property type="protein sequence ID" value="AEB42100"/>
        <property type="gene ID" value="VAB18032_04870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04870"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_0_1_11"/>
    <dbReference type="OMA" id="EMHRHKE"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="732" mass="79154" checksum="9C930D5CDD93DB39" modified="2011-06-28" version="1">MGSVQIVTTILAAAITAVAVWLAVRAVMQMTAVIRLGQPDPSRFGDKASRTRTMLAETAGHTRMLRWSVVGAAHWFVMVGFIVLSLLVLEAYFEVVSPTGGLPLIGGWALYGLVTEWIGILGIVGIVVLIAIRLANRPTKAGRRSRFTGSTMWQGYFVEAVVLAVLIMGFLIRGFKVATDHFEYPTWATPLSHAVGSALPDWESGVSVAALIKIAISMTWLIVISLNVTMGVAWHRFLAFPNIFFKRKPGAAGSGLGPLRPMMSDGKPLDFEEADPEKDQFGVAQVEQFTWKGLLDFSTCTECGRCQSQCPAWNTGKPLSPKLLVLSLRDHAYAKAPYLLAGGGKDLTGEEKATAAQLAHVDVLALAEAEKPLIGDAEAGGVIDPDVLWSCTTCGACVEQCPVDIEHVDHIVDMRRYQVLIESSFPSEAGVMLRNLENKGNPWGAPQNTREDWTKGLDFEVPRVGEVDDFEYLFWVGCAGAFEDRAKKTTRAVATLLNEAGVSFAILGEGETCSGDPARRIGNEFVFQMLAQQNVETLNEAFSGREKAKRKIVATCPHCFNTLGNEYGQLGGEFEVVHHTQLLAHLVATGKLTPVQPVDGGVTYHDPCYLGRHNRVFTPPREVLGSALGAGEITEMPRNSERSFCCGAGGARMWMEERIGKRINVDRVEEAMSTGAKTIAVGCPFCSTMLTDGVNGKGAGEQVEVVDVASVLLRSVRPEQARGAEEGEPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F992</accession>
    <name>F4F992_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10840"/>
    <dbReference type="EnsemblBacteria" id="AEB43286">
        <property type="protein sequence ID" value="AEB43286"/>
        <property type="gene ID" value="VAB18032_10840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10840"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_7_0_11"/>
    <dbReference type="OMA" id="PRMLRPI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="265" mass="28582" checksum="51834C0FED4F3163" modified="2011-06-28" version="1">MDAQPGRSVTSKVLALLDAFTPATPALTLTELARRAGLPLPTAHRRAAELVAWGALERGDDGRYRIGLRLWEVGSLAPRGLGLRELALPIMEDLYEVTHENVQLAVRQGLELVFIERIAGRHAVPVLTRVGGRFALHATGVGLVLLAYAPAEVQEQVLAAPLERYTELTITDPRRLRRCLAEVRRVGYAVSDRQVTMDALSVAAPIRGSDGVVAAISLVVAHDRADPLALAPLVQAAGRVLSRALGTSYRRPPGRVPSPTRSETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9E1</accession>
    <name>F4F9E1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_11085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732006.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11085"/>
    <dbReference type="EnsemblBacteria" id="AEB43335">
        <property type="protein sequence ID" value="AEB43335"/>
        <property type="gene ID" value="VAB18032_11085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11085"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_48_11"/>
    <dbReference type="OMA" id="CDAVQGW"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="280"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="520"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="792" mass="85197" checksum="6CD9E89B4DDCF3B5" modified="2011-06-28" version="1">MEPPDPRNLVPPGRAAQFTAFVAGVLAVAVLVSAGALASLATTLDALPVAFWTMAVLAVACDARPFVAPGQRQTSAVYPSSCFTFAILLGWGLGPAVAVQAVAVLVSGVRMGHAPWRTAFNAAQYACSLGAAYAVSRLGPGAAFDGGPLSWADVAAIGGAGVAWFLVNYGLVTAAVRLRFGERWWPNAWRGLPFELLSTGSLLLLAPILMTAARASAALVPLVLVPLFAVYRMARLTVEQRQLAALDPLTGLPNRKALLAEVNEQVHRHAERAARGEPDAHLALLLIDLDRFKNVNDALGHAVGDRLLVEVSARLTGVVEPPDLVARLGGDEFAIVMTGLTEVGQARAFADQVVRVLAEPVPLDGLPLDVGGSIGIALYPDHGEDFATLMRHADVAMYDAKHRNDTVAVYTAESDHNSAERLGLLADLRRVLEGGPTGQPHAAEATPPVRGGDGASMTVAAPVDGRTGQSWWSRRRRRLPTGVHDDELINQIVTAADPILRRSIQPTPPAPHDGEVWARPTDPDDSAESAPDAGEIMLYYQPQVEIATGEVVGVEALLRWRHPRRGMVDPEELIRVAEQSAVMRLLTRRVVDDVVEQLAKWSAAGVSLRAALNVSVRDLHTGEIAEQIADRLTRYGVAPERLQLEITEGALMADPRRVLATITQLHRIGVGIALDDFGTGYSSLQHLRRLPLSEVKVDRSFVLGMVDDSDDAAIVRSTIELAKALGLRVVAEGVEDERTWRMLHAAGCDAAQGWFYARPMPAEELVAWLARYRPVRPLATSDEAELPRRHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9W6</accession>
    <name>F4F9W6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734544.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23970"/>
    <dbReference type="EnsemblBacteria" id="AEB45892">
        <property type="protein sequence ID" value="AEB45892"/>
        <property type="gene ID" value="VAB18032_23970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23970"/>
    <dbReference type="eggNOG" id="ENOG50330QX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125494_1_0_11"/>
    <dbReference type="OMA" id="IAELTFD"/>
    <dbReference type="OrthoDB" id="1666209at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="15865" checksum="E964000B0E821E88" modified="2011-06-28" version="1">MEPWPPVDDDRLTVELGAALWNAGGVPEEYLTAARAAFAWRTVDAELTLAELTFDSAYEPVGQTRSGASVRTLSFRGGPIVLEIEVSAAGVVGQLCPAEGGRVSARTADGTYDETSVDAVGLFSLGVPPPGPVQLLAEAGGFTVATDWVCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Y4</accession>
    <name>F4F9Y4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00055"/>
    <dbReference type="EnsemblBacteria" id="AEB47095">
        <property type="protein sequence ID" value="AEB47095"/>
        <property type="gene ID" value="VAB18032_00055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00055"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065119_1_0_11"/>
    <dbReference type="OMA" id="RTTVHHS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="33390" checksum="A32DB00AB181E314" modified="2011-06-28" version="1">MIVAYGIANLLQSVAAARTTMQHTFDPGLLLRLAGHRAYLVGLVCQVGGFVLAFLARRDLPLFLVQASVAAGLGVTALLGVIVLKWRLPMAEVVLLLLLFAGITALVLSAQPAPSKPLGTAGVIALLVALGAIAVLGIFAVRLQGAPGSVALGSLAGLGFSAAAVAARPLASASTWDAFLTDPLLYLLIGHSIVGQLLLGLAMQRGSTTAAVAAMDAAGAVPAAIVGLLLLNDKIWPGREWLAGTGFLITLAAVIGLTRYAEPQHHHAVAQETTRAVLDGGVGGRQLPLVAPRPAEGRLCDSESTGPTRAASTQAASTGLRRPITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA50</accession>
    <name>F4FA50_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735806.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00385"/>
    <dbReference type="EnsemblBacteria" id="AEB47161">
        <property type="protein sequence ID" value="AEB47161"/>
        <property type="gene ID" value="VAB18032_00385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00385"/>
    <dbReference type="eggNOG" id="COG3945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115857_1_0_11"/>
    <dbReference type="OMA" id="IMESHFR"/>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="17397" checksum="6A05C0E3055989C9" modified="2011-06-28" version="1">MGEGEKTRLVAWSNELRRVHDRLREALTLTRDAVADGVPAESATRDLLLFCHGFCAALAAHHEGEDRDLFPAIAEQHPELRDTLYYLRQDHSMIAHLLTGLQTAVARAAPPAELDRHLEGLAAIMESHFRYEERQLLTVLDTLALTADPETVLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAG8</accession>
    <name>F4FAG8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ordered locus">VAB18032_11395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732066.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11395"/>
    <dbReference type="EnsemblBacteria" id="AEB43395">
        <property type="protein sequence ID" value="AEB43395"/>
        <property type="gene ID" value="VAB18032_11395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11395"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_0_1_11"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="152"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB43395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="368" mass="39183" checksum="22417D3035CEDECE" modified="2011-06-28" version="1">MTTPGKTRVAIVFGGRSPEHGISCVSAGSVLGALDPDEFEVVPVGITRAGQWVLTSGDPTELAINSRRLPEITAESGADIVLRADPTGSGLLVLDPTEGPRALANVDVVFPVLHGAYGEDGTIQGMLEMAGIPYVGAKVFASAAAMDKEFTKKICAAEGIPIGPYAVLRSGMTLSEEDKQRLGLPVFVKPSRAGSSFGVSKVSDWADLEAAIAIAREIDSKVLVEGAIIGREIECGVLEGEAGGTPEASVLAEVRVVGDYDFYDFEAKYIDAESACEYDVPADLPERVARQVRDYAVRAFTALDCAGLARADFFVTPELDIYLNEINTMPGFTPTSMFPRMWAASGLEYPKLVDRLIRTALTRGTGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAQ5</accession>
    <name>F4FAQ5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate enzyme-like TPP binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_17840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733325.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17840"/>
    <dbReference type="EnsemblBacteria" id="AEB44670">
        <property type="protein sequence ID" value="AEB44670"/>
        <property type="gene ID" value="VAB18032_17840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17840"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_4_11"/>
    <dbReference type="OMA" id="MGERACT"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="192"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="386"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="543" mass="55957" checksum="50B56F2BD49E372F" modified="2011-06-28" version="1">MKVYQLLADTLVAQGVDTVFGLLGDANMFLVSDLVARHGVRFVAARNENAAVMMADGYARATGRCPVATVTQGPGLAVAGAALTIARQARTPLVLVAGDTPPGDPGHVQSFPQQPFALATAGEMVPVVAAANVARDVATAFRLARSAPGPVVLNVPIDLQNDDVADDVPAPVAVAATRRPGPPAAHPDDVAMLAALLQQAERPVVLAGRGAEAAAAAVRELADRSGAVLATTLMAGGLFADHPYCLGVAGGLARPLARRVLGEADLVVAFGAGLNRWTADHGRLFGQATVVCVDIDPAALGDRWPVDVPVVGDAETVASAVSAVSAVLPVIPRPQWRSAELAREVAAADAFAGLQPLQAADRIDPRAFIRVCARRLPPQRTTVVGVGHFGGWPNLLLDSPATDRALIAPWEFGSIGVGLPFAVGAAVGRPDRPVVAFEGDGSLFTGLGELDTLARTGAAVLLIVLDDSAYGAEVRKLRPRGVDPALARFPDRDLAAVARALGVPAWTVTDEASADAAFDAVLPVTGPALLHVRVHPDAVQEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAT7</accession>
    <name>F4FAT7_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18000"/>
    <dbReference type="EnsemblBacteria" id="AEB44702">
        <property type="protein sequence ID" value="AEB44702"/>
        <property type="gene ID" value="VAB18032_18000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18000"/>
    <dbReference type="eggNOG" id="COG4403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104584_2_0_11"/>
    <dbReference type="OMA" id="PVPWPCE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="196" mass="22187" checksum="4E697DA168B8AC01" modified="2011-06-28" version="1">MPPCSDRSLPADVAAELVERMDRDQEARSGVPGRALDDAFWAWACQVDADNTAWLKQVIDRYGWPRRSDVGPEAATAAWLLAQHADHDPGFQRRCLALLDEAVRDGEARPRHLAYLTDRVLRAEGRPQRYGTQFWYGPDNAGPLQPQPIEDPEQVDERRHSVGLDTLAEYTERLRQRESGPQPSPESGERYPCRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB02</accession>
    <name>F4FB02_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endo-1,4-beta-xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_24335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24335"/>
    <dbReference type="EnsemblBacteria" id="AEB45965">
        <property type="protein sequence ID" value="AEB45965"/>
        <property type="gene ID" value="VAB18032_24335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24335"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321524_0_0_11"/>
    <dbReference type="OMA" id="YWSLTDR"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307769" evidence="6">
        <location>
            <begin position="33"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="7">
        <location>
            <begin position="409"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="GH43_C2" evidence="8">
        <location>
            <begin position="576"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="972" mass="105029" checksum="ABD2B7C33C99EDD5" modified="2011-06-28" version="1">MTALRPRRRGLALAAVGALVGAGAAVPGTAHAAEPWSPRPSYTSTDRGDGTYTVPLLRSDVPDISVERVPAAENDEGRDIYYMISTTMHLSPGAPIMKSYDLVNWEIVNYVFDRANIGDSFSLRNGQNSYGQGQWASSLRYHDGMFYVAFNTNNLGGAYIYRTDDIENGAWQRTALGRGLHDPSLFFDHDGTPYIFYGNGNISAVRLNAGLTAIVAEYPNVFTANDYAGQPFIGGLFEGAQFYYIDGHYYAVIITWPSGQGRQVVMLRSPELLGRHTAPGGVNTWQARGVLNSNGFAQGSLVPIARPGGATDWYGMFFRDTFPIGRIPALIPATWSDGWPTFGTAGVVPVEGAFDKPIRLSPAEELFERQKSIVVSDDFANDAPHKAYMDEQWTIPTPPAVDESLIGVELLDNAGFESDEVSPWAAQFGATLTRDTADPATGSAALKVSNRTLNGSGPHQYLAGKLQHGVTYTVSAKIKYTSGPSSIRFNLVADWGTGVQVMTFGTVPAGQWTTVTGQYTLPASANLSNVKFAVETPWANPQPATSSVEYLLDDVSIVGQRSTTEHPTEAEIRPNGSRLDMAWEWNHAPDNRYWSLTDREGWLRLTTGKVVTGNYVYTKLSNRAELAWFEEARNTLSQRTFGPRQSAETRMDISRMRDGDVAGLAAYNRGFSYVAVKRAGGVNTLGVVNRGQPFAVDLDQSTLENFLPGTTVALGDATEVHVKADLDFAAPTGQLWTTFHYSLDGLTWTQLGNRVGPQVLDGSLAHFMGHRVGLFNYATQQTGGQVDFDHFLLSDTLTAQNRPLDTTALDAAIAYAGTLDEAQYPADAWAAMRAALAAATSARAGEFGTQNQIDAPERALSYQLARLGVLRAATPELPVTVSAQTRCVAGKVYLAVQARNDHDGPVDVVVETTYGERSFPAVAPGANAYQQFTTRATAIPAGTATFRITGTVDGRDVTTVRTADHAATTCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB17</accession>
    <name>F4FB17_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24410"/>
    <dbReference type="EnsemblBacteria" id="AEB45980">
        <property type="protein sequence ID" value="AEB45980"/>
        <property type="gene ID" value="VAB18032_24410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24410"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1199385_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="24333" checksum="B08E7FE61F50A526" modified="2011-06-28" version="1">MVGRLVGSAVGANSGLVFEHRCELATYHALRGDAAAAQAVVAAIEDPPLDWPGAPALPAWRAWIVDPRNPATMAWLERSLVGLNRPVERLSRARLAWLLGGWHAHCGRRADAIRLLELASSEYAATGAAGLLARVAVDLASVAERAVATGAPPGGRSGQVPASATGSSAPAEAALTATERRVAAAVAEGLSNQEVAARLSVSIKTVEFHLRNAYRKLGVRKRTELVRHLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB72</accession>
    <name>F4FB72_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phage shock protein C, PspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_00665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00665"/>
    <dbReference type="EnsemblBacteria" id="AEB47217">
        <property type="protein sequence ID" value="AEB47217"/>
        <property type="gene ID" value="VAB18032_00665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00665"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348462_0_0_11"/>
    <dbReference type="OMA" id="TWESAPA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="20179" checksum="AA9D91363BD18BA2" modified="2011-06-28" version="1">MTSTPHAPYKQLRRPTTDRMVAGVASGVGRYLGVDPTLVRVVFAVGTVLTGGIAALAYPIMWFLMPAEPASAPAWPHPTGVPPQGPAGGPPPAGPAGPAPHPAWPYPAPGAPTPHHGPVPPATQYGPVPPATPVQVPPAAQHGTVPPVAQHGPVPPVAAAPPVSAATGTTSDAVQESSTPTVRIATAEGTAPTRPEAAAQPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBP6</accession>
    <name>F4FBP6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11970"/>
    <dbReference type="EnsemblBacteria" id="AEB43508">
        <property type="protein sequence ID" value="AEB43508"/>
        <property type="gene ID" value="VAB18032_11970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11970"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_0_1_11"/>
    <dbReference type="OMA" id="YTGIMTD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="2">
        <location>
            <begin position="75"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="3">
        <location>
            <begin position="318"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="40234" checksum="18D6C576701D7CE2" modified="2011-06-28" version="1">MTAPSGGATTEVGPADTPPGAARVGIGGAVPEQPGSSGSVPDRSAGTPAGSAGPTEADWAAAVAAVRRLPPDARVLLICHVNPDGDALGSMLGFGLGLRRLGVGRLQATFPGPPEVPEPLRGLPGMELLVPATEAEPEPDLVICFDAASTSRLGDLAGRLTGTGTALVLDHHASNPGFGDVNLVDPGAAATSVVAEELLARLGVPLDAGIAECLYVALSTDTGSFRFDATTASVHEMAARLLATGIRPGEISRRIFDNRPFGAVRLFGEVLGRARLEPAAAGGTGLVWTYATLDDLARYEQRPYVLEALIDPVRCTAEADVSCVVKQTGPAEWAVSLRSKGAVDVSRVAVALGGGGHRLAAGFTARGTVDEVIERIRTELDVPAVREGVDQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBS7</accession>
    <name>F4FBS7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733382.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18125"/>
    <dbReference type="EnsemblBacteria" id="AEB44727">
        <property type="protein sequence ID" value="AEB44727"/>
        <property type="gene ID" value="VAB18032_18125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18125"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_1_11"/>
    <dbReference type="OMA" id="HRTESNI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="43988" checksum="C4D1B250CDE632AF" modified="2011-06-28" version="1">MRSTDTTDTTDLPAFPMPSPFPGEPPIAFAQLREEKPVARVRLPTGDEAWLVTGHAENRIVLTDARFSRAAAAAPGAPRLQPIPPDPGSMLNMDPPEHTRLRRLVAPAFTPRRIEDLRPALRRDVDALLDDLLAAGPPADLVTGFARRLPVAVICELLGVPGSDRRRITEWVDLLLSLTTHPPQRIAAARREMKAYLAGLVESARDRPGNGLLSQVIEAYDEIGGTDDEEVVMLAATILTGGFLTTAGEIALSIVTLLRHPEQLAALRREPETLPRAVEELLRYNVLTTGGGLLRVATEDVVLGGVRIRAGEAVLPAISAANRDPRVYTEPDVLDFRRPDNPHITFGLGVHYCLGAKLARIELEEALAGVLRRLPPTLRLAGDMTALAVHPGHLVRGLPELPITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC02</accession>
    <name>F4FC02_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24510"/>
    <dbReference type="EnsemblBacteria" id="AEB46000">
        <property type="protein sequence ID" value="AEB46000"/>
        <property type="gene ID" value="VAB18032_24510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24510"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_1_0_11"/>
    <dbReference type="OMA" id="WVDQDLQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="199" mass="22369" checksum="9B9F6428568B44A5" modified="2011-06-28" version="1">MVREAEEFAERMAQRRSVRDFAPDPVPEKVIEAAIRAASTAPSGANVQPWRFVVLTDPARKRRLREAAEAEERAFYDHRASTEWLGAISGLGTDWQKPFLETAPAVIVVFEVHQGPHSPKPYYVKESVGIAVGVLITALHHAGLVTLTHTPSPMRFLNEVCERPREERPYVVMPVGYPAPDARVPDLARKPLDEVMIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC90</accession>
    <name>F4FC90_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_00925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735913.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00925"/>
    <dbReference type="EnsemblBacteria" id="AEB47269">
        <property type="protein sequence ID" value="AEB47269"/>
        <property type="gene ID" value="VAB18032_00925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00925"/>
    <dbReference type="eggNOG" id="COG5553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130991_0_0_11"/>
    <dbReference type="OMA" id="WHIRLAP"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="109" mass="11938" checksum="C60B545D707F1DA2" modified="2011-06-28" version="1">MTGNSPATPATDQDLVLGPVGQEIVLENDRVRVWHIRLEPGEQQPLHRHDHPYLVVAVQGAKNVIQTVDGVRIDADEPTGGVVYRDPGAVHMLTNVGDTTYLARLVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCA8</accession>
    <name>F4FCA8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="13" type="ordered locus">VAB18032_01015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735931.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01015"/>
    <dbReference type="EnsemblBacteria" id="AEB47287">
        <property type="protein sequence ID" value="AEB47287"/>
        <property type="gene ID" value="VAB18032_01015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01015"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_11"/>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="OrthoDB" id="662686at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="232"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="36983" checksum="077B574E659C07A2" modified="2011-06-28" version="1">MLISQRPTLSEESINETRSRFTIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIKIDGVLHEFTTIPGVKEDVVELVMNIKELCVSSEHDEPVSMYLRKQGPGDVTAGDIQPPAGVSVHNPDLKLATLNGKGRLDMELTVERGRGYVTAAQNKQAGAEIGRIPVDSIYSPVLKVTYRVEATRVEQRTDFDRLIIDVETKPSMGPRTALASAGSTLVELFGLARELDETAEGIDIGPSPQDAQLAADLALPIEELDLTVRSYNCLKREGINSVGELIGRTEADLLDIRNFGQKSIDEVKMKLAGMGLGLKDSAPNFDPAHVVDAFGEADYDTDDYRETEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCG2</accession>
    <name>F4FCG2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730962.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05815"/>
    <dbReference type="EnsemblBacteria" id="AEB42289">
        <property type="protein sequence ID" value="AEB42289"/>
        <property type="gene ID" value="VAB18032_05815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05815"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_76_11"/>
    <dbReference type="OMA" id="ETNRGVM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="224"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="441" mass="47956" checksum="75A76AD6377E021E" modified="2011-06-28" version="1">MALRVEQDIFVVRQRGREVAAAVGLERQDQVRIATALSEVARDLLRGVGGADVLFAITAAPDGRQHLRVDLVPVSPLPDRRYEPQSGAVARLVDTLSVVAAAGDTVVRMSRRIPVTAQALTPQRVEQLRAQLGQSVPGTAEEELATQNSQLIAALDEVRSQRDELARLNEELEQTNRGVLALYHQLTDELEETNRGVVALYAELDEKSVQLRSASESKSRFLANVSHELRAPVTAIIGLARLLTDAASDPLTLEQERQVGLIRSSASDLLSLVNELLDLAKAESGRLEPDWAEVDLRALFGQLRGTLRALHTVPDVRLVVEEPPSPATIRTDEMLLAQVLRNLLHNGLKFTTRGEVRLRAERSGDSWKLVVTDTGAGIPAEFHERVFEEFYQVPGPSRAGGTGLGLPYARRLATLLGGTLELSSEPGRGSSFTVSLPANGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCG5</accession>
    <name>F4FCG5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Two component transcriptional regulator, luxr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05830"/>
    <dbReference type="EnsemblBacteria" id="AEB42292">
        <property type="protein sequence ID" value="AEB42292"/>
        <property type="gene ID" value="VAB18032_05830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05830"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2332833_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="98" mass="10841" checksum="E8DFD6D7E568C4CB" modified="2011-06-28" version="1">MRGEQPGLAVVVLSQHVQPEYASALLDSADGRRVGYLLKDRVAEVTDFVDNLRTVLAGGAVIDPDVVRRLPHRPRDPLAALTAREREVLVLTRPPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCI7</accession>
    <name>F4FCI7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-5'-phosphate-dependent protein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730987.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05940"/>
    <dbReference type="EnsemblBacteria" id="AEB42314">
        <property type="protein sequence ID" value="AEB42314"/>
        <property type="gene ID" value="VAB18032_05940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05940"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046285_0_0_11"/>
    <dbReference type="OMA" id="ESIFEQM"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="39"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="363" mass="39514" checksum="EDF5A14D93971624" modified="2011-06-28" version="1">MTQLDRCDEASRRWVTEAIAAVEADANRSADTHLLPFPLPRRWGIDLYLKDESVHPTGSLKHRLARSLFLYGLCNGWIGPDTTIVEASSGSTAVSEAYFARMLDLPFIAVMPASTSPEKIAQIEFQGGRCHLVDDPAKVVIEARWLAEDSGGHYMDQFTYAERATDWRGNNNIAESIYAQLSLERHPVPAWIVVGAGTGGTSATIGRYARYRRLPTKLCVVDPENSAFYPAWQAADWSVRTGQGSRIEGIGRPTVEPSFLPSVVDRMMRVPDAASLAAMRSASAVLGRQVGGSTGTNLWGAFGLIAELLAAGRTGSVVTLICDAGDRYADTYYSDEWVSAQGLDLAPHLATIDRFLTDGSWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCV5</accession>
    <name>F4FCV5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18425"/>
    <dbReference type="EnsemblBacteria" id="AEB44787">
        <property type="protein sequence ID" value="AEB44787"/>
        <property type="gene ID" value="VAB18032_18425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18425"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008878_4_2_11"/>
    <dbReference type="OMA" id="AKICYVT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="3">
        <location>
            <begin position="441"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="541" mass="58434" checksum="D19BBEC63E48D9DD" modified="2011-06-28" version="1">MIGSGFGGAITAYHLAAGGARVVVLERGPWLTGEEFEHDFKFGSSSTRVFDFVVGDGMSVLSGNCVGGGSVVYFAAMPRAPRFVFDRQGRFGHRMWPSSISRDTLDPWYDRVAEALPVSQTSWDTVPFSGGLFGAACDHAGRTANPVPVALDQAKCTNCNWMMAGCRFDAKRSLLLNYLPAALAHGAQIRPLHEVQYLSRTDDGGYRVHYTVLDDVDYRVEVGSGTIDAKIVIIAAGAGATPVILQRSEPTLGAMPHAVGRYFSGNGERLNTAIFDEERIRDVLGLSRPDGVPYEAYQIGKGPCVANWDRLDGSLPEYERFSLEQLYFPPGFGTILAQVPDAVGPTWFGAEKKELLRTWQSWLTVFTMSEDDNEGEFGAVPPSGNAVRLSQQMLARGSLRYEPTENTLRGWALSDAEVRDILERDGLSRVMPWTNDVVGAYTVHPLASCRIGDNPATSALDDRHELRNHPGIFVTDGSAVPAGLTVNPAMTIAALAERAVPGIVAAARARGVDVQYGAPAPDGATSSRDAVLPLARSALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD30</accession>
    <name>F4FD30_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_18800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18800"/>
    <dbReference type="EnsemblBacteria" id="AEB44862">
        <property type="protein sequence ID" value="AEB44862"/>
        <property type="gene ID" value="VAB18032_18800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18800"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_8_11"/>
    <dbReference type="OMA" id="RERAPEC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="22714" checksum="A0A1973C043C7BFC" modified="2011-06-28" version="1">MVVVDDQTLVRQGIRGLLEVAQVDVVGEAADGRAALSVIAQTMPDVILLDLRMPRFDGIWTIEQLKAADIDIPVLVLTTFDDDALVLGALRAGARGYLLKDVTLEQLTRAIHTLADGGTLIAPSITDRMLRAIRSGPSPAGPDAPTVQSLTEREREVLRLVAHGYSNREIAGALFLAEGTVKNHVSMILTKLGARDRTNAVLRALHEGILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD32</accession>
    <name>F4FD32_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733519.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18810"/>
    <dbReference type="EnsemblBacteria" id="AEB44864">
        <property type="protein sequence ID" value="AEB44864"/>
        <property type="gene ID" value="VAB18032_18810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18810"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_8_11"/>
    <dbReference type="OMA" id="KPSIYHH"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="20206" checksum="32D7F73735841B16" modified="2011-06-28" version="1">MSPHTDTRAQIMDAFAEQLAATGYQGISLAQVGRTVGIQKPSIYHHFPGGKEDLYIAVAERYIRDVGGRLAAALVDHRDVEERLGTLAAVVAGQKGESITFEQRIYDALHLVSDETRDHVRACYVNLVLDPVTAFFTSARDQGVVAGEPAFLMNAFLHLARAADLTDDTDPTRIVALFLDGARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD95</accession>
    <name>F4FD95_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavoprotein wrba</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734777.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25135"/>
    <dbReference type="EnsemblBacteria" id="AEB46125">
        <property type="protein sequence ID" value="AEB46125"/>
        <property type="gene ID" value="VAB18032_25135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25135"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_2_11"/>
    <dbReference type="OMA" id="KFADGNP"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="205" mass="21618" checksum="5CDDA3F04F947BE6" modified="2011-06-28" version="1">MAAQVKVAVIYYSATGITYQMAQAASEAAGDAGAEVRLRKVRELAPDEAIRSNAGWSAHHLETQHIEEAQLDDLSWADVVILGAPTRYGMVAAQLKQFIDTTGPLWAKGALVNKVYSAFTSTATKHGGQESTLLSLFNVFYHWGGIVVTPGYTDPSQFVAGNPYGASHVSNNGETAPDDIALTATALTARRAVQIGAAVKKGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDG2</accession>
    <name>F4FDG2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01445"/>
    <dbReference type="EnsemblBacteria" id="AEB47373">
        <property type="protein sequence ID" value="AEB47373"/>
        <property type="gene ID" value="VAB18032_01445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01445"/>
    <dbReference type="eggNOG" id="COG3396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3085998_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="52" mass="5808" checksum="C026CF95AAB647EA" modified="2011-06-28" version="1">MAAEVGNYRRPADRLTALGVRPDDAMAPYVEPRQAYHELTVPHDWAEAVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDH5</accession>
    <name>F4FDH5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01510"/>
    <dbReference type="EnsemblBacteria" id="AEB47386">
        <property type="protein sequence ID" value="AEB47386"/>
        <property type="gene ID" value="VAB18032_01510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01510"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_1_5_11"/>
    <dbReference type="OMA" id="AYAKQTE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307648" evidence="3">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="34"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="40041" checksum="2663274A43E32A1F" modified="2011-06-28" version="1">MFLSAATMMAATMVATACGSPQDTANGGGDSAAPVKVGLVYSQSGALASYGKQYIEGFRAGLDFATGGTNKVGDRAIEITEVDDAGDPAKAVSAAKDLIGKGNKIIAGSTASGVALQVAPIAAQNKVLFISGPAATDAVTGVNKYTFRSGRQSYQDVVTARSFIGDPTGKKVVVFAQDGAFGDANEAAVKEIIGGAGATVSAVRAPASATEFTPFASQIKSAKPDLLFVAWAGTTAPAMWQTLDQQGVLSSTTVVTGLDIRASWPTFGAAGTKISFLSHYFDGASDTEAAKAAKAKIPGGTLDLFHPDGFAAAQMVVRAVQEGGDDVEKMITALEGWSFEGVKGTMTIRAEDHALLQPMYQASLTGSGDTFTATAQKALTGDEAAPPVQAMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDJ2</accession>
    <name>F4FDJ2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoK</name>
        <name evidence="6" type="ordered locus">VAB18032_06155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731028.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06155"/>
    <dbReference type="EnsemblBacteria" id="AEB42355">
        <property type="protein sequence ID" value="AEB42355"/>
        <property type="gene ID" value="VAB18032_06155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06155"/>
    <dbReference type="eggNOG" id="COG0713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144724_0_0_11"/>
    <dbReference type="OMA" id="NFVAFSY"/>
    <dbReference type="OrthoDB" id="2081663at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="105" mass="11442" checksum="8AB92C6CE42803A9" modified="2011-06-28" version="1">MSDFFSVEPNYYLVLAAVLFTIGAAGVLVRRNAIVLFMCVELMLNAANLALVTFSRMNGDLNGQIMAFFVMVVAAAEVVVGLAIIMAIFRTRRSASVDDANLLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDX1</accession>
    <name>F4FDX1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_12690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732320.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12690"/>
    <dbReference type="EnsemblBacteria" id="AEB43652">
        <property type="protein sequence ID" value="AEB43652"/>
        <property type="gene ID" value="VAB18032_12690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12690"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_6_4_11"/>
    <dbReference type="OMA" id="RGWTREF"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="55"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="242" mass="26185" checksum="548C1253667666AB" modified="2011-06-28" version="1">MESVGNALRALRYLGAQESVSVADLGRHLQVAPSTAHRLLSTLKEFDFARQDDSRRYRLGPAAHEVATRQAPWDVVAAVRPHMEDLAATTRETVNLIGLQGASIVFLDGVESTQTVRVGVRTGDRLPAYTTAGGKALLAQMRPKDIRALHPRILAALTSATITTTDQLIKELDAVRARGYASNLEECVDGVYAVGVAVVHPTRGAVAALTISAPAHRVDERRADLLAQQLLQANTRLTQGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDZ2</accession>
    <name>F4FDZ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43673">
        <property type="protein sequence ID" value="AEB43673"/>
        <property type="gene ID" value="VAB18032_12795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12795"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535211_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="509" mass="53359" checksum="AB232D9468FED122" modified="2011-06-28" version="1">MTQVPAEVRGLGPALLAVPLTDEATGLLALERFGDDLAGLTPARRHTQVALGGDPRFPTVARGLGEDRRDAVLVDGRLRDVTLPDFGYADRAFSVESNLSITESRCLTVTGDGRVGLPAVEAFCKIADRGGVIWEQGQSGRYGGIDLASGAASPAVELPSKPIAATPDGRYLAALTSQDPRQLVIADTRTGQSRPTVTVSGADRGAEFPGVFTSDGFAVLRRPVPGTRRISLVTPKGEVRDLLSPVGEVAFAPDGRRAIVVDTRSGKGRLSVLDLKSGAVTPVVGDGTEQPDRPAELPPVTGTVTATVSGDHALVVELEAGPDPRQRVPRPSRAWSVRLSTATATSHPNTPEASEVTVWRHEFPPTDAAALSALWFAPGKQTLTLSPDGTVTSAPPGTFPRETLGDGAVLHTLLAESGRERVDRLLVTDSSGGRVEIPTGAGPDQRVANVILTPDQQHLLISLRPLNSRTAPGDLDVVMIARRDGTGKPVVVYQGAWLVSLGIVPTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE16</accession>
    <name>F4FE16_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-n-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733540.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18915"/>
    <dbReference type="EnsemblBacteria" id="AEB44885">
        <property type="protein sequence ID" value="AEB44885"/>
        <property type="gene ID" value="VAB18032_18915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18915"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_11_1_11"/>
    <dbReference type="OMA" id="FNFNWWQ"/>
    <dbReference type="OrthoDB" id="386120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307836" evidence="5">
        <location>
            <begin position="35"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="6">
        <location>
            <begin position="336"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="611" mass="65440" checksum="38D1F3C28ADD2B26" modified="2011-06-28" version="1">MEFAPLRGRPVRRWLAWLAVPLMLVTFLAAPAKADNPFVQHVYTADPAPLVHDGRLYVYTGRDEDASTYFTMKEWRVFSTTDMSNWTDHGVPMSLSTFAWADANAWAGHVVARNGQFYWYVPVRQRSNGQMVIGVGVSSSPTGPFRDALGRPLVGNGEIDPHAFIDDNGQAYLYWGNPNLWYVRLNQDMISFSGSPTQIPLTTAGFGTRTGNSSRPTLYEEGPWVYKRNGVYYNVFAAECCSEFIGYSTAPGPTGPWTYRGTVMPRQGASFTNHPGIIDYAGNSYFFYHNGALPGGSGYTRSVAVERFSYNADGSIPVMNMTTAGAPQIGTLNPYVTQEAETINWGNGIETEASSEGGVNVGFIENGDWIRVRGVAFGAGASSFTARVASATSGGTIELRLDSATGPLVGSCAVAGTGGWQNWANTSCTVSGATGTRDLYLRFTGGSGYLFNLNNWRFTAGSGSGANLLTNGTMENGTTGWSVFGSGTLSSATTVVRSGSRSLLHSGRTGSWNGPSQDVTSALTNGRTYTTTLWVRSQSGTPSVRPTLAVTANGTTSYVQLTPAATVNANGWTQLTGTATVSWSGTLSNARFYVETASGTDSFYLDDVSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE29</accession>
    <name>F4FE29_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metalloprotease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44898">
        <property type="protein sequence ID" value="AEB44898"/>
        <property type="gene ID" value="VAB18032_18980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18980"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007507_0_0_11"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313834" evidence="3">
        <location>
            <begin position="22"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="5">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="473"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="923" mass="96831" checksum="4B36BC295A7DF285" modified="2011-06-28" version="1">MVLTTTLVASLTTLAANPASAAPEEAPARSNPLFLTGPNAGAAEDIAIRYLRGNAAAHGVNAADLSDLSILSSYTSRHNGVTHVNLAQRHQNLEVFGAVATVNIAKDGSVILVGETLVTDLAKGTSGTADLNAVDAVEAAADALDLAAPKSPKVLSRAGGAAQKTVVSESGISDEPIPAKLGWQPTEDGLRLAWQLVIDDSSDSHLWNATIDAETGELLDVDDWTTQHEAHEVADNLDALAPGRATTLNTAAFHTHEPVQDGSSYNVYAGPAESPNDGPRTVVTNPADRVASPYGWHDTDGAPGAEFTTTQGNNVHAYQDTDSNNAPDFGSSPDGGPSLTFDNPVDLNEHAQSYRDAATANLFYWNNIIHDVTYRYGFDEASGNFQMNNYGRGGVGGDYVRAEAADGNGTNNANFSTPAADGGAPRMQMFLWPGNQFGAQNQVVVDGVGSFDATWSRFSPAPSVAGLPGHRFVYAGTGCNTAAYPATLPGGNWIAVVDGGTAACTYLLRTQVAQSLGAKAVVVAHNATSAAPVLTGAMTTAPVAIPAVAVSQADGNAIKAAIAAGDVTGSVRKHPSHPGIRDGDFDAGIIIHEYGHGISNRLTGGPGVNCLSGNEQMGEGWSDYFAVTMLLDPALDTADGVRGMGPYALFQEDRSGAGIRPRPYSRNMDIQPFTYDSIKTGGWLNGTSLAAPHGIGHGWAAVLWDMTWDLIDRHGFNPNVYDAWNTGGNNLSLQLVMDGLKMQGCGPGLVAGRNGIIAADAALTGGENACTLWASFARRGLGYSAVQGTTNRDDNTEAFDTHPSCRGDFLNRTGMNTLDAGDAAPMQFQLASNRGLDILASNSPYSRLVDCDTLQTVNPSGPITPRPTPVKAVNPGNSKMSVNAKGRYNYVWKTDPAWAGTCREFVLTLDNGFQYRTYFKFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE69</accession>
    <name>F4FE69_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate lyase</fullName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Isocitrase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Isocitratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19180"/>
    <dbReference type="EnsemblBacteria" id="AEB44938">
        <property type="protein sequence ID" value="AEB44938"/>
        <property type="gene ID" value="VAB18032_19180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19180"/>
    <dbReference type="eggNOG" id="COG2224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_0_11"/>
    <dbReference type="OMA" id="LEKDWAE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="PTHR21631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="315"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="430" mass="47150" checksum="E8DD2CED5D8A00B0" modified="2011-06-28" version="1">MVKGHETMPTPVEQLQHEWDTNPRWRGVRRSYRAEDVVRLRGAIQEEHTLARHGANRLWRLLNSEDYIHALGALTGNQAVQMVRAGLKAIYLSGWQVAADANLAGHTYPDQSLYPANSVPAVVRRINNALLRAAQITTAEGDASGIDWLAPIVADAEAGFGGVLNAYELMNAMIAAGAAGVHWEDQLASEKKCGHLGGKVLIPTGQHVRTLEAARLAADVAGVPSVVIARTDAQAATLLTTDVDERDQPFVTGERTAEGFYRVRNGIEPCIARGLAYAPHADLLWMETSTPDLEVARRFAEAIKAEYPDQLLAYNCSPSFNWRKHLDDATIAKFQRELGHMGYKFQFITLAGFHALNYSMFDLARGYATDGMAAYVSLQEREFAAEPAGYTAVKHQREVGTGYFDLISTVLNPAAETTALRGSTEEEQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE99</accession>
    <name>F4FE99_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734817.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46165">
        <property type="protein sequence ID" value="AEB46165"/>
        <property type="gene ID" value="VAB18032_25335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25335"/>
    <dbReference type="eggNOG" id="ENOG5031S3V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1739738_0_0_11"/>
    <dbReference type="OMA" id="NGNWLLL"/>
    <dbReference type="OrthoDB" id="1789148at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="149" mass="16385" checksum="0B7960692C2BD291" modified="2011-06-28" version="1">MAIEYRLTLAGNIPLEQVAELVAPEGVEESTQPGDPRLLGADLTHTSGYSLSIYAGSNGYFDAEDDDGSQWEWEPDSYVNIVFHMPKDDSLRAATPNMVAAVARVLAGRPEDAALVLNGNWLLLTRVAGTLRKHRPAWWDNHLITINTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEN1</accession>
    <name>F4FEN1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">murB</name>
        <name evidence="19" type="ordered locus">VAB18032_01945</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB47473">
        <property type="protein sequence ID" value="AEB47473"/>
        <property type="gene ID" value="VAB18032_01945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01945"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_0_1_11"/>
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    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="28"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AEB47473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="360" mass="37909" checksum="95CC161E587C0A5E" modified="2011-06-28" version="1">MPDVYAQPTAAAQPVISGELSQYTTLRLGGPARRIVTATTAEEIVAHVRQAGEHALLLAGGSNVVIGDAGFPGTVILVRSRGLRVLTEDEQTVTIRVEAGEPWDDLVAATVRNGWSGLECLSGIPGSTGATPIQNVGAYGQEVAETIVGVQVYDRSTGTITQLDAADCGFAYRASIFKYSERWVVLAVDFRLARSALSGPVRYAELARALGVEVGDRVPLAHARATVLELRAGKGMVLDAADPDTRSVGSFFTNPVLDAAEYEELRQRAADIGEPPAWPGAGDLVKVSAAWLIDKAGFGKGYAGPEGVAISSKHTLALTNQTGTATTEALLTLAREIRDGVHARFAVTLHPEPVLITCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FER0</accession>
    <name>F4FER0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731127.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06650"/>
    <dbReference type="EnsemblBacteria" id="AEB42454">
        <property type="protein sequence ID" value="AEB42454"/>
        <property type="gene ID" value="VAB18032_06650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06650"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_3_11"/>
    <dbReference type="OMA" id="GWTDRDE"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="22836" checksum="23660042EB98F720" modified="2011-06-28" version="1">MEFADVVRRRRMVRNYDPDRPVPPEVVERLLDHAVRAPSAGFSQGWGFLVLEEPADRERFWAATTPEGGGTGRWLAGMRRAPLIVVPHANRSVYLDRYAEADKGWADRSTDRWPVPYWYIDTGFAALLMMLTAVDEGLGSCFFGIPPQRLEPYREAFGVPEEYHPIGAVTVGYRAPDHRSPSLRRGRRPVDEVVRRGRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FER9</accession>
    <name>F4FER9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_06695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731136.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06695"/>
    <dbReference type="EnsemblBacteria" id="AEB42463">
        <property type="protein sequence ID" value="AEB42463"/>
        <property type="gene ID" value="VAB18032_06695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06695"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="HHGHESL"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="433" mass="46925" checksum="685965CBAFAACBAA" modified="2011-06-28" version="1">MSTVALKDVTKVFRDGTVAVDSINLDVNDGEFMVLLGPSGCGKSTVLRMVAGLEEPTSGAVMLDGEVANDLPPRERGIAMVFQDFALYPHMSVGDNIAFPLKLAGVEPAPRGERVTDVASALGIGDVLARRPSQLSGGQRQRVAMGRAIVRRPKLFLMDEPLSNLDSGLRAELRAEISGLTRELGVTTIYVTHDQAEALTMADRVAIMRKGVLQDVGTPTQVYGRPATLYVAAFLGSPRMNLLEASVYVHLDRYVTLTLGEQALYLPWDDIRSRAVAHYHGERIVVGMRAEALTPVAPDAPGDVLQGRIRYLEHHGHESLAFLDIGATAIVVDEVGAAPDSDTPLGQRGLRRFGQVMQRFTGRAAEPQANRNSGSQASVLADPGRHHRRPAELAVRLAPYPAVSAGHPLAIKVRMDALHFFDERGDRIDVGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FET2</accession>
    <name>F4FET2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper ion binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731149.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06760"/>
    <dbReference type="EnsemblBacteria" id="AEB42476">
        <property type="protein sequence ID" value="AEB42476"/>
        <property type="gene ID" value="VAB18032_06760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06760"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_13_1_11"/>
    <dbReference type="OMA" id="HCVNAIT"/>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7035" checksum="39C148D4BCF40D48" modified="2011-06-28" version="1">MVTTTYQVQGMTCGHCVGAVSNQVGALPGVTDVTVDLPAGRVTVTSEQPLDENAVRAAVDEAGYELLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEX1</accession>
    <name>F4FEX1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_12845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732351.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12845"/>
    <dbReference type="EnsemblBacteria" id="AEB43683">
        <property type="protein sequence ID" value="AEB43683"/>
        <property type="gene ID" value="VAB18032_12845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12845"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033996_0_0_11"/>
    <dbReference type="OMA" id="PTHNSQA"/>
    <dbReference type="OrthoDB" id="623081at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0270">Exopolysaccharide synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Stealth_CR1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR2" evidence="5">
        <location>
            <begin position="276"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR3" evidence="7">
        <location>
            <begin position="426"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR4" evidence="8">
        <location>
            <begin position="502"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="599" mass="67406" checksum="B35C4F7CA1183E1E" modified="2011-06-28" version="1">MIALRVYRLLPPAVRRHLLRLLPEHQRLAMVRTLTRPRGGETVHPVGARVTVSDDGVRSEAEVVAAATPLQMWHRNLTAVTSSLESAGIEYHCVRNDDYLRSTVAVLDDKRDALRRLVRSAPELSGAQVRIVEVRPERHQPDRAPTEVIQVWFPVTDARAGVVLGAQFACEIELWTRVGDVVRAPRHNAVIDEAPARAEPVRVAAALLSHFVPEADDHTYGTRRDLAVRAPDRVGFPIDAVYTWVDGSDPEWRERKQAAMGTPGGPLHAIAANTSRYHNRDELRYSMRSLHSFAPWLRKIFVVTDSQLPSWLDPTHPMITVVSHAELFADIGGLSSFNSHAIESRLHRIEGLAEHFLYLNDDVFLGRPLLPTHFFHANGIAKFFLSPAQFGLGEARPSDPPVNAAGKNNRRHIQRQFGVTITQKMKHTPFALRRSIMHQIEAMLPADVLATARHRFRHHEDLSIPSSLHQYWAYLTAQAVPGHIEYEYADLGHPSTPARLAELLAHRNRDVFCLNDTDSDPRAFEEQERMLADFLPRYLPFPAPFELPDDEVAERRNLGASALWRDAQRPVPGTRQAPQVDAPTLPNSRRSSLGDFQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF51</accession>
    <name>F4FF51_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733611.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19270"/>
    <dbReference type="EnsemblBacteria" id="AEB44956">
        <property type="protein sequence ID" value="AEB44956"/>
        <property type="gene ID" value="VAB18032_19270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19270"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="OMA" id="MKAWLYS"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="34638" checksum="7C817AB88335B538" modified="2011-06-28" version="1">MRAIVQDRYGPPETLRLADVDVPVPAAGEVLVRVEAAALNAYDWHIVRGDPWMSRLAFGPAKPRARIRGRDFAGRVSAVGPDVHQVRPGDAVFGDLGDANGAFAEYVCVPEALVAPAPTNLTPQQAAALPLAGVTALMGLSDVGRVEPGQRVLVNGASGGVGTLAVQLAKALSATVTAVCSTRNVDLVRSLGADHVVDYTRDDFTRDGRRHDLVFDLVGNRSLTALRRAVTPTGTLVLSGGGVHRRGSLLGPVWLLTRGRLLAPVVGQRIAILTATPSRAHLDTLRAYVEAGRLAPVIDRTYPLHEVPQAIGYLEGEHARAKVVITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF89</accession>
    <name>F4FF89_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733649.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19460"/>
    <dbReference type="EnsemblBacteria" id="AEB44994">
        <property type="protein sequence ID" value="AEB44994"/>
        <property type="gene ID" value="VAB18032_19460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19460"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_11"/>
    <dbReference type="OMA" id="NTVVFQF"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="346" mass="35318" checksum="99D27496DB5ADD29" modified="2011-06-28" version="1">MSETLSTAASPAAAPPPPTRPPSRTLAIARLRDLALVPAIIAVAIVGFVVNPVFLSSDNIINVLQSMSEIAIVVLAQTIVLITGKMDLSLESTFGLAPGIAAWLVVDPALTRGLGLDVLPSAWAVPVVLAVGALVGAFNGLLIVRFGLNGFIVTLGMLIVLRGLLTGISGGKTFFALPESMTYLGSASWFAVPVSIWVSLLLFAVGIVVLGYTRAGRALYAIGGNVDAARAAGIRTDRVLWIALIVASMLAALAGLLISGRLASVPAAQGSGAIFQVFAAAVIGGVSLNGGKGTVFGAFTGVLLLFMIINVLTLAGVPAQWTNFLNGTVILVALVVSRITGGKAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFA7</accession>
    <name>F4FFA7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic binding protein/LacI transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_19550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19550"/>
    <dbReference type="EnsemblBacteria" id="AEB45012">
        <property type="protein sequence ID" value="AEB45012"/>
        <property type="gene ID" value="VAB18032_19550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19550"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_2_11"/>
    <dbReference type="OMA" id="EWRTANT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307867" evidence="2">
        <location>
            <begin position="26"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="45"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="35024" checksum="8FF11522E8A0F902" modified="2011-06-28" version="1">MSLAPRRAVAALAAVLLAGGMAACGNSDTGTDEGGSGDGKIVMGFSQVGAESGWRTANTNSIKEAAAEAGIELKFDDAQQKQENQIKAIRNYIQQKVDVIAFSPVVESGWDTVLKEAKDAGIPVILTDRAVDSADKSLYKTFLGSDFVKEGRLSGEWLVEQMKSATGDVNIVELQGTTGSAPANDRKKGFGEAIAADPKLKVIASQSGDFTRAGGKQVMEQFLKAHPKIDVLFAHNDDMGLGALEAITAAGKEPGKDIIIITIDAVKDGMQALADGKFNFIAECSPLLGPQLMELAKKVHAGEEVPPRIETEETTFTQEQAKEALPNRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFD5</accession>
    <name>F4FFD5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25695"/>
    <dbReference type="EnsemblBacteria" id="AEB46237">
        <property type="protein sequence ID" value="AEB46237"/>
        <property type="gene ID" value="VAB18032_25695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25695"/>
    <dbReference type="eggNOG" id="COG5496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119426_3_0_11"/>
    <dbReference type="OMA" id="VFATPAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025540">
        <property type="entry name" value="FlK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934">
        <property type="entry name" value="PTHR36934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014972">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="3">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR014972-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR014972-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="14441" checksum="DD19D3370B37BCB3" modified="2011-06-28" version="1">MAMQEQPDRVLTPGLAARVEMTVTDDDTAQAVGSGDVPVLGTPRVLALAEAATVAATARHLPAGTTTVGTRVELEHLAATPVGRTVTAQARLTAVDKRRLTFEVTVVEGEQTVAQGRVERVVLDRQRFIERAGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFL9</accession>
    <name>F4FFL9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02060"/>
    <dbReference type="EnsemblBacteria" id="AEB47496">
        <property type="protein sequence ID" value="AEB47496"/>
        <property type="gene ID" value="VAB18032_02060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02060"/>
    <dbReference type="eggNOG" id="COG3246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065536_2_0_11"/>
    <dbReference type="OMA" id="VPEYEIF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="270" mass="28812" checksum="6EE4BB7C307445CC" modified="2011-06-28" version="1">MITVAPTGAESAKTEVPALPVTLDELLLTAKECEALGASIIHVHIRDDDARPTLDLGRLRATVAALRESTDLIVQLSTGGAVTDPEADRLAVLDAAPDMASCTMGTVNFGDDVFLNRWEFIVDLHTRMQERGIVPEYEIFDLGHLTALRRLLDKYGLPHGGHVHVDFVMGVPGGMPGTTATLVAAQQMLRDLPEGTTFSATGIGRSSIPVMLASLSAGGHLRVGMEDTVTYAKGRPVESNMQLVARAVGFAQLAQRPPLNTTQARELLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGA3</accession>
    <name>F4FGA3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propeptide PepSY amd peptidase M4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733696.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19695"/>
    <dbReference type="EnsemblBacteria" id="AEB45041">
        <property type="protein sequence ID" value="AEB45041"/>
        <property type="gene ID" value="VAB18032_19695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19695"/>
    <dbReference type="eggNOG" id="COG3182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031962_3_1_11"/>
    <dbReference type="OMA" id="QHTVYVD"/>
    <dbReference type="OrthoDB" id="1656356at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="481" mass="50941" checksum="218EA9F2748A2E68" modified="2011-06-28" version="1">MSLTDVSGPPDSAPEPSTVEPPSGRPQRRSSPLAALLVRLHFYAGVLVAPFLVVAALTGLAYTVTPQLDRALHGDQLIVTTSGEQPRPLAEQITAARAAHPDGSLVAVSPGTADRTTAVVFALPELGDKQHTVYVDPYTGTVAGQLTTWFGSTPVTTWLDDLHRNLHLGAVGRHYSEIAASWLWVLALGGIILWWRRRATGRGRVRHLLVPDLSTGRGVRRTRGWHATLGVWLAVGLLVLSATGLTWSRFAGGNFSAGLTALDAARPTLSTSLTAAPVDGGGEHHHGGAPSPTAEPATFDRVLAVARDAGLDGPVEISPGEAGEAWVVAQTDNTWPVGWDRVAVDPDAGTVTARSDYADWPLLAKLSALGIQAHMGVLFGLVNQILLAALAIGLLCVIVWGYRMWWQRRPTRVDRRALVGAPPARGALRGLPWWALLPGVPLVAALGWALPWFGVTLLGFLAVDVALGLAARRRTGLTSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGA9</accession>
    <name>F4FGA9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protocatechuate 3,4-dioxygenase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733702.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19725"/>
    <dbReference type="EnsemblBacteria" id="AEB45047">
        <property type="protein sequence ID" value="AEB45047"/>
        <property type="gene ID" value="VAB18032_19725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19725"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_5_0_11"/>
    <dbReference type="OMA" id="YRWDIVL"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03464">
        <property type="entry name" value="3_4-PCD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024756">
        <property type="entry name" value="PCDO_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012785">
        <property type="entry name" value="Protocat_dOase_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12391">
        <property type="entry name" value="PCDO_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02422">
        <property type="entry name" value="protocat_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="245" mass="28011" checksum="57B94D87DABA4666" modified="2011-06-28" version="1">MSETTRKLLLPGYRRDDVEAHPPLLSPGYKSTVIRAPQQPLTYLPQRLTEITGPLLGEGRLGELDHDLTRQHDGEPQGQRIIVHGRVLDGDGRAVPHTLVEIWQANAAGRYRHAIDNWPAPLDPNFTGVGRTLTDEAGRYEFVTVQPGAYPWRNHDNAWRPAHIHFSLFGRAFTQRLVTQMYFPGDPLFSQDPIFNSVRDPQARERMVARYDHAATRPEWALAYRFDIVLRGREATPFEDEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGC0</accession>
    <name>F4FGC0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_19780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733713.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19780"/>
    <dbReference type="EnsemblBacteria" id="AEB45058">
        <property type="protein sequence ID" value="AEB45058"/>
        <property type="gene ID" value="VAB18032_19780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19780"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036302_1_1_11"/>
    <dbReference type="OMA" id="HMFVMGR"/>
    <dbReference type="OrthoDB" id="311112at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB45058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="460" mass="47708" checksum="D55A4837DBD9BE00" modified="2011-06-28" version="1">MPSRQDQLHSYQFTLQRVVAALVMRETDPAQSPFRRLAGAGLASVLVAVIGLGGFALYGLFTGGAVKWRDTGAVIVEKESGARFVYRDNRLHPVPNYTSALLVIGTEQPKTVLVSRRSIDGVPRGLPLGIADAPDSLPAANRLSAAPWTVCSTGPQAGRRDPRSVLLIGTGDPGGRPLRDEALILRDPGGRLHLVRQQRRHLIRDADRVLAALATTRARAVPVAAAVLNTVPAGLDLAPLRLPDLGEPSERVVDARVGDVLLVSNSGGGRQYAVVLRDGLAGVTELQAGLQLARTGQREPEQISLGRFAALPKLPDLAPEGPDAPPSTPPRLAAPGSPVLCALVGDDPTGVDLRLDATLPDLSAATPTVAAAAGRTVADHVLVEPGSGALVEATATPGAVGGALCVVTDLGRRYVLADAEVAAMLGYGQTRPVRLPAGLVSLVPAGASLDPQTARRAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGV2</accession>
    <name>F4FGV2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_02640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02640"/>
    <dbReference type="EnsemblBacteria" id="AEB47612">
        <property type="protein sequence ID" value="AEB47612"/>
        <property type="gene ID" value="VAB18032_02640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02640"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080174_0_0_11"/>
    <dbReference type="OMA" id="LLYDWPL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="25461" checksum="3DCDB83368F2F342" modified="2011-06-28" version="1">MAALLAVGIGHPPQGIATVAITVAASQFAVGWTNDLVDADRDALVGRADKPVAAGLVSRRLVAVAAAVAATTTVALALTTNPVAALCATIGLVSALLYDWPLKSTAVSVLPYAISFGALPAFVVLALPGAPAPPLWLVAAAALLGAGAHFANVLPDFADDARTGVRGLPHRLGPAGSRLAAVGLLVAATGTLVLGPPGPPSGVGLATVAAALMITASAWYAGRSAERAGVRPVAAFRAMMLVALIDVVLLVTSGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGW0</accession>
    <name>F4FGW0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02680"/>
    <dbReference type="EnsemblBacteria" id="AEB47620">
        <property type="protein sequence ID" value="AEB47620"/>
        <property type="gene ID" value="VAB18032_02680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02680"/>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099864_1_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307896" description="Peptidase_C39_2 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="53"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="22652" checksum="90E939D5EB74889F" modified="2011-06-28" version="1">MTMTTLIYKAALTVAGAVVAGGVVAGPTGAVAASPNPSQQAADRGHAKGERQLKVRYQAQPNYYYCGPAAVRNALTAMDKDVPQDELAREMGTTERGTDSAYDITKALNERVGKDVYRTVEIPGRAADGAETDRLRADIVRAVDEGRSVVANVAGTALDLDGGTHSFEGGHYVSVTGYRDGGAQAKIADSADPAKAEYWIGIEALADWVATRGYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGW4</accession>
    <name>F4FGW4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ordered locus">VAB18032_02700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736256.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02700"/>
    <dbReference type="EnsemblBacteria" id="AEB47624">
        <property type="protein sequence ID" value="AEB47624"/>
        <property type="gene ID" value="VAB18032_02700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02700"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066627_1_0_11"/>
    <dbReference type="OMA" id="HEPWLTL"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="27024" checksum="29D599A2849ED4D4" modified="2011-06-28" version="1">MLLCIDIGNTNTVLATFDGDQLVHSWRIKTDARSTADELGLMFRGLLAGDAVEITGVAACSTVPAALRSLRTMLTRYYGELPSVIVEPGVRTGVQLAIDNPKEVGSDRVVNTLAAYTLYGGPSIVVDFGTTTNFDVISGRGEFLGGAFAPGIEISFDALAARAAQLRKVEATKPRSVIGKNTVECLQAGLYFGFAGQVDRIVERMAEEMGELKAVIATGGLAPLVLNECRTITHHEPMITLMGLRMVYERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHR9</accession>
    <name>F4FHR9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_26826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735089.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26826"/>
    <dbReference type="EnsemblBacteria" id="AEB46438">
        <property type="protein sequence ID" value="AEB46438"/>
        <property type="gene ID" value="VAB18032_26826"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26826"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_5_11"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="218"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="412"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="738" mass="78728" checksum="A9A95741ECB71836" modified="2011-06-28" version="1">MPSRSEEPRRDATGSRRGSSRGASDRGVPPRATGERGGEPGIGGISDARAYTPRGRTIREGGGTPAAGRTEQRRTPRSSRSQDPFRPALQVLDGGRAAATRAGGRPGGPTRRDGGTGRTPVVRTVTARTPGGEAVEPPRRRVGGRDPRREERAAPRRPARKPPRPPRLADPVRRLRLGTALVMAMFVAIGIRLVVLQAVDTPAYADGGVADRLRTVQLPAPRGAIYDRDGAALAHSVEARYVYADPTRVEDIESTARTLSPLLGIPASELAEKMRPRKRYGVDSRFEYLARGVDIDRAREIMKLELSGIYTQRDERREVPGGDLAANLIGFTSIDMAGLEGLEARYDDLLHGEDGERTFEIGLGAPIPGGYSRTTPAKPGSSMVLTIDRDLQFMCQRILSEQAKAAQASTAAAVVIDVRTGEVLAQASEPTYNAARPQHSDPTDREDAATSFVVDPGSVHKAITFGAALQEGVITPDTSFPVSNAIRKGDTWFPDTHFANGRRMSVAGMMAYSSNVGTIQIADKLGPERLIDYQRRFGLGKPTGVGMPGEASGRLLPLSEWSDSSHGSVPIGHSVDATPLQMAAAYAAIANDGTYVQPHLVKETIDPQGNRTPAEPPATRPVLSPDNAKALRTIMEAVTTVENATGLAAAVPGYRVAGKTGTGWRLVDGKKQPGDVASFIGMAPAENPRYVIAVFVHSPSGGGGKVAAPAFRDMMTFTLRHFKVPPSSEAPPKFTVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHW0</accession>
    <name>F4FHW0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736285.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02845"/>
    <dbReference type="EnsemblBacteria" id="AEB47653">
        <property type="protein sequence ID" value="AEB47653"/>
        <property type="gene ID" value="VAB18032_02845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02845"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008270_1_0_11"/>
    <dbReference type="OMA" id="ELTPHWL"/>
    <dbReference type="OrthoDB" id="175945at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309349" evidence="2">
        <location>
            <begin position="29"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="359"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="851" mass="89109" checksum="4812958D363F3055" modified="2011-06-28" version="1">MNAVGGPKVRALRAAALHRRAAATVAAAATSLDDTRPAPADQRRQYALAERLRTAAAVLAPDWAGNALDGIESTTRAGEAPPPFVRVGTAAPLDDARFPALVPLLGTGHLTVDTDAQDPRVAGMLRGLMLRLVAATPAGTLLVRAVDPTGDVLAPFGALGDAGLLSPPARDVAGLRALLDEAERWVTPGSTGPRRHDRMLLLVLAGLPERTGNDELTRIESLAEQGPAAGLHLVVAGWPTVDHAPLPRATALAMRTGYALLGDAPGAAFAAAGSEGGLNSPVFVEPDPPAGLVEEVCRRLAAQVEAGTRLSLASLLPSTEDELWQADAIEGMSTTVGDAGGRAVSLGFTELTPHWLVSGRSRACRSTFLTTALLGLTARYGPDELSLYLADLGEGESFAEFLQTERDRSWVPQVRAAAMAADREYLLDLFDQLTAEVQRRAEASARAGGQRFAELRQHQRLPRIVCVVDNLPLLFAERDRLTVDAAARLDTLTRTGRLHGVHLVLAGEADLGLGVRTEGGQRDSLLGQFPVRVALPGGGAVLEPTNDSAAGLPAGSAVVNTAGGLGGPRGAIRGHERMIRFPDPQDEPEVVEGLRHRLWSARTEGAVPPVVFAGYARPQLGNDPRYRSALAGRSLAPAALLGRAVDVARTTAAVPFGPAAGRNLAVLGPRPDGSRLLSVAARSTAAHHPPGTARFVIAVPDVEARPVADALATELAARHPVETVDLAGLVAVLDDGAPAYLVVFGLDVAPAEDLPPARLRMLLREGPPAGQHLLGWWRTVPSFAALIAAEETVDKLTAVAVAGVPGAQLTPVFGRPVEWRPRPDRVVLWDGPDEQGVVLVPYDVPEGGQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHX7</accession>
    <name>F4FHX7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02930"/>
    <dbReference type="EnsemblBacteria" id="AEB47670">
        <property type="protein sequence ID" value="AEB47670"/>
        <property type="gene ID" value="VAB18032_02930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02930"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_1_11"/>
    <dbReference type="OMA" id="LWAYWCA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309351" evidence="5">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="74"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="22835" checksum="707258EC0099D02E" modified="2011-06-28" version="1">MIRRLALLTVPLLLAATAACTAESETPTPARQDPAASRPSPFADCAALTSAPDGSRDDGAPDGSADDRPAGDTGSGGSQLPELSLTCFTGGAPVALREVRGPAVINIWASWCPPCRKELPAFQRLSERAEGQLRVIGVNTQDSRSAAQSIGEDFGVRFPMLVDQGQAMQRALRRNAFPMTLFLTADGQIRHIDTSGALDDAQLTELVAQHLDITVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI61</accession>
    <name>F4FI61_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
            <plasmid evidence="1 2">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30309"/>
    <dbReference type="EnsemblBacteria" id="AEB48025">
        <property type="protein sequence ID" value="AEB48025"/>
        <property type="gene ID" value="VAB18032_30309"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30309"/>
    <dbReference type="eggNOG" id="ENOG5032SQM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116620_0_0_11"/>
    <dbReference type="OMA" id="ATEWASG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB48025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="183" mass="19781" checksum="EC5EBF240D561DF5" modified="2011-06-28" version="1">MKSPTVAARRTRPTAVPQLPLAVIPENHHRDGWPPVWWVGCHGGAGTSTLARLVGIGTDFGTAWPALTSAMPGAHVVLVCRASASGTWSATGAVEQWRRRAGVARMTWLLGVVAVAASPRRPPRIATERLRLLGGWAPQIWRVGWIDDLLAVDEPTDIGTPPDIEALRTAIWHTLHAKQKGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F121</accession>
    <name>F4F121_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731348.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42675">
        <property type="protein sequence ID" value="AEB42675"/>
        <property type="gene ID" value="VAB18032_07775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07775"/>
    <dbReference type="eggNOG" id="COG2732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121832_1_1_11"/>
    <dbReference type="OMA" id="YFGWNWN"/>
    <dbReference type="OrthoDB" id="2047621at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="106" mass="12186" checksum="441D46C48ADDC765" modified="2011-06-28" version="1">MVDADQVSYDFSDALLFPSYFGWNWNALSDCLRDLHWLPADGYLVIIDNAPQLLPDSSHDRHTLFRILAKAVHHWASPLGQPEGKVVPFKVLLLCDRDEEGRRERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F172</accession>
    <name>F4F172_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731399.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08040"/>
    <dbReference type="EnsemblBacteria" id="AEB42726">
        <property type="protein sequence ID" value="AEB42726"/>
        <property type="gene ID" value="VAB18032_08040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08040"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_11"/>
    <dbReference type="OMA" id="LNPFPKN"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="3">
        <location>
            <begin position="255"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="615" mass="65854" checksum="8FB76960806D4CB5" modified="2011-06-28" version="1">MTKQIRQLDRVVIRFAGDSGDGMQLTGDRFTSETAQLGNDISTLPNFPAEIRAPAGTLPGVSSFQVHFADYDILTPGDAPNVLVAMNPAALKANLTDLPRGADIIVNTDEFTKRNLAKVGYASSPLDDDTLDGYAVHPVALTSMTIGALAELDVSKKDAERAKNMFALGLLSWMYSRPYESTLRFLERKFAKRPELVAANVAAFKAGWNFGETTEDFAVRYEVKPAKMPAGTYRNITGNAALSLGIVAAGVRSGLPVFLGAYPITPASDILHELSKHKRLGVTTMQAEDEIAAIGAALGASYGGALGVTTTSGPGVALKSETISLAVALELPLLIVDVQRAGPSTGMPTKTEQADLNIALFGRHGEAPVAVIAPKSPSDCFYAALEAARIALTYRTPVILLSDNYVANGSEPWLLPDVESLPDLRVEFATAPNGEDGTTFLPYLRDPQTLARPWAIPGTPGLEHRIGGLEKADKTGDISYDPANHDFMVRTRAARIETIPVPDVEVEDPDGDARVLVLGWGSTYGPIGAACRGLRQRGLPVAQAHLRHLAPMPANLGAVLRSYDRVVIPEMNLGQLAHVIRARYLVDAIGYNQVRGLPFTAAELETMLEEVLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F195</accession>
    <name>F4F195_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14095"/>
    <dbReference type="EnsemblBacteria" id="AEB43931">
        <property type="protein sequence ID" value="AEB43931"/>
        <property type="gene ID" value="VAB18032_14095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14095"/>
    <dbReference type="eggNOG" id="ENOG5031NP4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111140_0_0_11"/>
    <dbReference type="OMA" id="RASCHDN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307579" evidence="2">
        <location>
            <begin position="41"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="19451" checksum="9E488A473DDC46E0" modified="2011-06-28" version="1">MTRTRPALSAATFAAPVLTLITVAPLLAMALVGAPTPARAAGPAAAHVVGQPVAAPQPPGPNVFIEVSPSTVEPGHLVGLRASCQDNSVGAIAVSDAFGRVAVQPQRGLLTGTAQVKDRVLPGNYRVKLECRGGESASTMLQVVRAVKPSRGPATGFGGGAGGTSGLLLPGGLALTVSGTILWVVAARRRQTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1G9</accession>
    <name>F4F1G9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_20490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733852.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20490"/>
    <dbReference type="EnsemblBacteria" id="AEB45198">
        <property type="protein sequence ID" value="AEB45198"/>
        <property type="gene ID" value="VAB18032_20490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20490"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037625_0_0_11"/>
    <dbReference type="OMA" id="DELYFIA"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="72"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB45198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="516" mass="54454" checksum="9734755AE29120A2" modified="2011-06-28" version="1">MGAVTRSTAPETDLGQPRRPGPPAPGPRSGGPWLVAAAVTILLLIMAPRYGYHRDELYFLLAGRHLDWGYVDQGPLVPALARLVDTIAPDSLLALRTPSALLAGAAVLMVAAIARQFGAGRGAQTLAAALGGASGITLASGHLLSTTTVDLVIWLAAALCTVRLLRTADSRWALAVGAVVGIGMLNKLLPALLAVGLLAGLAIAGPRRLLRDRTVLLAAGIFALLAAPTLLWQATHGFPQLGVAATISGGDSSYSGRLDAAILQFLIISPFVVPIWSIGLFVLVRRPAWRRYRSLGWAWLVVVGVVLLAGGKGYYPAPLLLVLTAAGAVVAAQWAQHGRARVRRVLLAAVVVLTAASNTVLLLPALPVDRLPGFVVAVNYDTGETIGWPAFTDSLAAVHRRLPADEQARAVILTGNYGEAGAVARYGPQRGLPAAYSGHNSMADFGRPPEDADVVIAVGWQQPQQLRTWFTEVTLAGRVDQRVAVDNDENGGPIWLCRGLRRPWADIWATEVRHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Q4</accession>
    <name>F4F1Q4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735130.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27031"/>
    <dbReference type="EnsemblBacteria" id="AEB46479">
        <property type="protein sequence ID" value="AEB46479"/>
        <property type="gene ID" value="VAB18032_27031"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27031"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_0_11"/>
    <dbReference type="OMA" id="SQWLAWP"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="197" mass="21722" checksum="53CFE2F43BB85424" modified="2011-06-28" version="1">MFAVRLTADAELRPLNPWHAEEFLANLDRARKNMTPWVSPAFVATDLDGARLVLQRYADRWARDDGGIWGIWSDGTLVGGVLLVSLNAGTGVCEAGCWLEPAAEGRGLVTHAVSRLIDWAVDERGLHRVEWRVLSGNVRSIAVARRLGMRRDGVLREVVAGPDGRSDLEIWSLLAPEWRAHRAGAPRGTDGGERLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1X4</accession>
    <name>F4F1X4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="5" type="ordered locus">VAB18032_03185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03185"/>
    <dbReference type="EnsemblBacteria" id="AEB47721">
        <property type="protein sequence ID" value="AEB47721"/>
        <property type="gene ID" value="VAB18032_03185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03185"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_11"/>
    <dbReference type="OMA" id="WPDKVID"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="58"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="590" mass="65372" checksum="3B66271DB24B5B16" modified="2011-06-28" version="1">MTQETFAMAHQASTTDIDPIARQRPSGMPYRRYEPYRQQFRIDLPDRTWPTRHVEAAPRWCAVDLRDGNQALIDPMSPERKRRMFQLLVQMGYKEIEVGFPSASQTDYDFVRQLIEQDLIPEDVTIQVLTQCREHLIERTFESLRGARRAIVHFYNSTSTLQRRVVFGLDRDGIADIATTGARLCQKYAEIHTPDTDIHYEYSPESYTGTELEYALEVCAKVIEVIDPTPDHKLIINLPATVEMAMPNVYADSIEWMHRHLPRRDSLVLSLHPHNDRGTGVAAAELGLLAGADRIEGCLFGNGERTGNVDLVTLGLNLFSQGIDPMIDFSDIDEVKRAVEYCNQLPVHERHPYAGDLVYTAFSGSHQDAINKGFAALNADAAAAGVPVDEFTWAVPYLPIDPKDLGRSYEAVIRVNSQSGKGGVAYIMKTEHQLDLPRRLQIEFSGVVQQVTDHDGGEVAPETMWQIFAAQYLLDHQSDPRVTLTEYAIGTADGKVEITAQVDVAGKPQALTAIGNGPIDAYVNALASTGVAVRVLDYHEHALSSGGDAQAAAYVECEVDGRTVWGVGMDANIVTASIKAVTSAVNRAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Z8</accession>
    <name>F4F1Z8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_03305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736377.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03305"/>
    <dbReference type="EnsemblBacteria" id="AEB47745">
        <property type="protein sequence ID" value="AEB47745"/>
        <property type="gene ID" value="VAB18032_03305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03305"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_11"/>
    <dbReference type="OMA" id="FAGIHFT"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="11">
        <location>
            <begin position="56"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="541" mass="58528" checksum="ADF372984F17FBB7" modified="2011-06-28" version="1">MDAVTTTPAPVNEPNLSYAPGSPERAGLTAKLGELAGQRFELDLTIDGRRRIGGGDRIDIVQPHRHRHVLGTLGNATHDDARAAVDAAKRAAGDWRALSFDERAAVFLKAADLLAGPWRQTLNAATMLGQSKTAFQAEIDSACELIDFWRFNVHFARQIRAEQPQSSPGVWNRVDHRPLEGFVYAITPFNFTAIAGNLPTAPALMGNTVVWKPSPTQQLAAWWTMRLLEAAGLPPGVINMVTGDGLAVSDVALADPDLAGIHFTGSTSTFQHLWRTVGERIGSYRSYPRIVGETGGKDFIVAHPSADVDVLRTAMIRGAFEFQGQKCSAASRAYVPRSLWPELREDLIAEVESLTMGDVTDLSHFMGAVIDGRAFARHAVAIERARATASCEILAGGGYDDSEGWFVRPTIIECTDPTDEVFTTEYFGPILAVHVYEDEAYEATLAQLESVSAYALTGSIIAQDRAAIAHAAQVLRFAAGNFYINDKPTGAVVGQQPFGGGRASGTNDKAGSAQNLLRWTSARTIKETFVPATDHRYPHMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F248</accession>
    <name>F4F248_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08095"/>
    <dbReference type="EnsemblBacteria" id="AEB42737">
        <property type="protein sequence ID" value="AEB42737"/>
        <property type="gene ID" value="VAB18032_08095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08095"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_2_0_11"/>
    <dbReference type="OMA" id="RGMRPDG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="202" mass="21119" checksum="B8805BF98C590C1A" modified="2011-06-28" version="1">MHFAESYVPEDLVLRTARSLANEVGLDAVTPGAGAALRLLAAAGNARAVVEIGTGTGVSGVWLLRGMRPDGVLTTIDVEVEHQRIARRIFTEAGFVAGRTRIITGRALDVLPRLADGAYDLVFVDAEATGFTACVDAALRLLRPGGVLVLNGALAGGRIGDPAARDAETVTVREAVKAIRESEHWIPALLPVGHGLLAAVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2A8</accession>
    <name>F4F2A8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 1 extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731468.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08395"/>
    <dbReference type="EnsemblBacteria" id="AEB42797">
        <property type="protein sequence ID" value="AEB42797"/>
        <property type="gene ID" value="VAB18032_08395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08395"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035417_0_0_11"/>
    <dbReference type="OMA" id="ILYHQQP"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312623" evidence="1">
        <location>
            <begin position="41"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="558" mass="60500" checksum="05E8B7F9C69CC883" modified="2011-06-28" version="1">MTRHNPGVPTSRRSFLSLFGLGAVAVAGGPLLSGCSEAPAGSGAAQNLGAFGHLLPAHKGLTGSIAPDIAGIRPVPDGYVKYPSSLVDLITEKPGTSGKEITAMTPAWGPAPPGIGQSAYLQAVNDELGVPVNFTIQDGNTYADKLNAMLGARDVPDLLCVPSWEVDKIPRFAEAISVLFEDLTDHLKGNAVEAYPMLATFPTEAWRHSVWNERLAAVPNPTDGPFAWVMFTRKDVLDARGLAIPTSLDDLLAIAKQVTDPARKVWAFNDVFPMIQMYHKVPGAKQGWRLRSDGTPEFKYETPEFRQALEVMAKVYQDGLVHPDIVASRGADAKQLFAKGGNIVFMQDGFGFWQGGQAEHQKANKALNIQPVPNFSATGGDPLVWGSDQPISYTFVKKGLGEERVKELLRVINWCSAPLGSQEAQLRDFGVEGRHHTRTPNGPVKTDLAFKEINNQYFFISGRNPTIGPFADTPNYVRDALAYSNATVGYLEKDPWAGVKLEMPAAFKANQVPTEDKFTDVLRGRRPLSDVDSILQEWKAAGGEAARQLLADSLPKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2E5</accession>
    <name>F4F2E5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis lauroyl acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_14525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14525"/>
    <dbReference type="EnsemblBacteria" id="AEB44017">
        <property type="protein sequence ID" value="AEB44017"/>
        <property type="gene ID" value="VAB18032_14525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14525"/>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049421_3_0_11"/>
    <dbReference type="OMA" id="GMRSYMR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="33004" checksum="6D93B69FA5E6C205" modified="2011-06-28" version="1">MAAGERHSPATGVPVNLTEIGFVAGWRLVRALPRPVAAAAFTAGADRAHRRRGAGATRLRANLRRVVGPDLSEAELDELVRAGLRSYARYWMEAFRLPSLSREQVLATFRLDGAELLAADVAAGRGAVVALPHAGNWDLAGAWVVANGWPLSTVAERLKPEAVYQRFVAFREGLGMEILPTTGGHRPPLDVLTDRLNDGAVVPLLADRDLSARGVEVDFFGGRTRMPAGPALLALRTGAPLYVASMWYEPDAACASLEGPLPVPGHQDGTLDKRVRSLTQLIADGLAAGIARHPQDWHMLQRMWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2G4</accession>
    <name>F4F2G4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14620"/>
    <dbReference type="EnsemblBacteria" id="AEB44036">
        <property type="protein sequence ID" value="AEB44036"/>
        <property type="gene ID" value="VAB18032_14620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14620"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="YEHGVVR"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="25393" checksum="6E4B5F297DC07022" modified="2011-06-28" version="1">MSTAAGHAEESGSDRPIRVLLADDHHLVRTGFRVILEIEDDIEVVGEAADGHRAVSMTRALRPDVVLMDVEMPDVDGLEATRRIRAEQDQAGPAVLILTTFDRDDYLFAALRAGASGFLLKNGTPEALIEAIRVVARGDGLLAPEITRRVIATFARPGGPSTGGTDPQAALRDLTPREREVLVLVAGGASNAEIATALHLGEATVKSHVSRVLAKLELRDRVQAVVFAYEQGVVRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F382</accession>
    <name>F4F382_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_03895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03895"/>
    <dbReference type="MEROPS" id="S54.A08"/>
    <dbReference type="EnsemblBacteria" id="AEB47861">
        <property type="protein sequence ID" value="AEB47861"/>
        <property type="gene ID" value="VAB18032_03895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03895"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_2_1_11"/>
    <dbReference type="OMA" id="PVCPRHP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="101"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="27994" checksum="8D6B4F6CD4CCB62F" modified="2011-06-28" version="1">MNEASVGFQCPECVSEGRRSVRPARTAFGGGAAGRHGYVTKALIAINVLIMLVSIASDRGGDAAAGGTGFGGLMGGSTPLTEWGAVLGRAMFLDGSIGGVAEGQWYRLVTAMFLHYGILHLLLNMWALWVLGQSLEAVLGPLRFAALYFIAGFGGNVAVYVFSPPNQMSAGASTAIFGLFAAIFVIMRRLGRDTSAILPILVINLIFTFTVPQISIAGHLGGLVFGGLMALVLAYAPRSHRTLVQAVGGTVIMVLLLGAALIRTVALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3J3</accession>
    <name>F4F3J3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase caa3-type, assembly factor ctag-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_14945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732768.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14945"/>
    <dbReference type="EnsemblBacteria" id="AEB44101">
        <property type="protein sequence ID" value="AEB44101"/>
        <property type="gene ID" value="VAB18032_14945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14945"/>
    <dbReference type="eggNOG" id="COG3336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054944_2_0_11"/>
    <dbReference type="OMA" id="HVFLAGY"/>
    <dbReference type="OrthoDB" id="1553593at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="28258" checksum="8E348C0D95DE3AF5" modified="2011-06-28" version="1">MSVAHTAQHATTVGPAVLVPLVAGWCYLAAVLRQREPDRPGWSHWRTAAFAAGCALLAVALLLPADGFAAHMWQHLLLGMLAPLGLVLGAPGTLLLRTVDRRVGRAALRALRHPVARTLAHPVTGLLLTAGGLWLLYLTPLYRATLASPVLHDLVNLHFLLSGLLFTWSIAGPEPYRHRASVPVRLVVLGAAVVAHASLAQLLYAGLLVDVPAPPQALRAGAAVMYYGGDAAEILLALALLASWRPQPRRAPAPAARQTLKGDPCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3V1</accession>
    <name>F4F3V1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734055.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21510"/>
    <dbReference type="REBASE" id="34485">
        <property type="entry name" value="VmaORF21510P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45402">
        <property type="protein sequence ID" value="AEB45402"/>
        <property type="gene ID" value="VAB18032_21510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21510"/>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003916_0_0_11"/>
    <dbReference type="OMA" id="SLWLDTM"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1678" mass="188143" checksum="FAAB20B9CC52F107" modified="2011-06-28" version="1">MSFESLTNRGEYLSAHYLAEILPTTLKAGLVKQWTEREKANQQTPRSGLRGLRRPYFDAKTELADDEFFDPERLRKLHQELLKALGFEPAPQTITVERAGHQHEITVAHAELGTAHGIVALDCGWAVDTEAAQDPDAAGRLLAPVTLPGNETVTTGAKLASWLFAAEQPPRYVLILSGGVVTLADRAAWGEGRYLAVSLDTAYARNDDREYDVVAALFGADSLRPPAEGGTEPLADLVAGSRQHAVGVSSELREGLKVSVELIANEVLDRIRAAGYQPGQVMVLDELAKELGREALRYLYRILFLLYAEARPELGVLPVNDPQYVEGYSLARIGDLVARRLPPSAEDGTHLYESLDLLFRMVNDGHRPRGGTEIEATASEGEGLRFEPMKSDLFLPEKTKLIGRLIPVPGSDEDDPDGPTIDTRLRNKVLYEVLRRLMLTKGGKRRRGGFISYAQLGINQLGAVYEGLMSYTGFVATEQLYEVAKNGDPKDGSWMIPASKADEYDDNVFVYRENAYTGIRSRVVYEAGQFVYRLAGRDRQTSASYYTPQSLTEVTVQLALKYRLDQDDTITLARELLDWTICEPALGSGAFLNEAINQVAAEYLRRRQKELDTTLDPEDYHLELQRVKAYIALHNSYGVDLNRTAVELAEVSLWLNVMHAGLQAPWFGLHLQRGNSLIGCGRKTYEAKQLADKSWLTTAPAEKPFRDGPIDPDTIHHFLLPADGWGAVAGEKEARELAPAETAKLKAWRTAMKRTPSAKGKNSQVKRLQALGRRVEFLWGLVQQRLAISEREIRRDIKVWGADDLPEVREAVAREDILADLTAPGTPYWRLKTLMDVWCALWFWPLDKVGLLDGSDPAYPTTPVQVEHVKDIPAYEDPAVYEAADLFGNVQPQQMKLPTKATGTRRTTVAEQLRKQVPLTNLDDWLTFAEALIGRTEVDENTERFFARDFTNLDEMSEFEQKLEGVIGVDSPWTLADRFPWLLTAEHIADQQGFFHWELTFAQGFAKGGFDLQVGNPPWVRPDWERDLVFAEIDPWFGIGSAAEGVRATRVKAVLLHEPQARYVVNEYVSNVGIATFLSSAATFPLLNGTRPDLYRPFMCLVWLNSTASGIAGLIHPDTHFGGVREGVLRSESYVRLRLHAHFQNRRLIFSEVDNNKQFGIHVYGKRSAVDFDHLSWIFDPATLLWSLSHDGTGPIPAIKHDGAWDVRPHKERIIRVTGEVLVKWHRLAGDSDLPLTQTKLLYPVSSREQEVIAALIEAKPRLHEVEPRIAVGLLETDAKRLGIIVEELCSPTSWQDVVLKGPQFSVATPFAKSPPIPKRGGKPVDLVALSSDEIPRSEYRLAEGRHLYEDRAAERWIDYRELDRLRAQPASVQEVRESLARQRGEVPAAVPEEAIEEALKDLSKRRSFDFFRVVWREMVPASTERSLFPALVPPGPKHIHAVRSMALKTNLETVMVAGFWASLPLDYTVRVAGRGHLDVADARGMPVPATNHPLTHALVLRTMRLNCLTSAYAPIWRELFSREWVDEDWALDWPSVAPLGRVSTEWDSCSPLRAERERRAALVELDALVAVYLGMDVEGLITIYQSRFPQLAAYESAMYFDSGGKKIASAFDAYGAGQTKDHYTALLKYLDDQQRNPVPEGYMAPFYKADRENEYRQAHAVFSRRLQDAIDAGWRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F498</accession>
    <name>F4F498_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04145"/>
    <dbReference type="EnsemblBacteria" id="AEB47911">
        <property type="protein sequence ID" value="AEB47911"/>
        <property type="gene ID" value="VAB18032_04145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04145"/>
    <dbReference type="eggNOG" id="COG4880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015706_3_0_11"/>
    <dbReference type="OMA" id="FQGAYVY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019198">
        <property type="entry name" value="Beta_propeller_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09826">
        <property type="entry name" value="Beta_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="644" mass="69245" checksum="61AAA17DDBBC1850" modified="2011-06-28" version="1">MRNRTTTGGVEADMMRASRVVAVGSTLVALTLLAGSTAGPNPVRPTGSVMVPVAALTSFDSCAEALTELRAAARDSVGPYGFEDGTLLSARAAVAAGAEGGSQPLGDAGPDHSKTNNHEADADEPDVVKTDGRRIVTVTSGMLRVIDPAGRRITGQLDLPGAEADAYWGSYRLLLHGDRALVLADGSPFVTMDRAWPTPPVESARLFLVDLAGAPTVLGSYRIEGSLLDGRLTGDTARVVVRTAPRIEFPLDAIGSDRARTRQNRAIIDRAGIESWLPEYEWTAGDERHTGRVDCDRLSRPKRMTGTSLLTVLSFDLAADQLGAGDPVSVAADATTVYGTARSLYLAGQQPQPGMGLLRWRPTVRDQVTEIYQFDTSEPGRPHYLAAGTVPGWLINQYALSEWDGHLRVATTVGDVWGEERRSESTVRVLRRDGGSLVPTGAVGGLGRGERIYSVRYLGHVAYVVTFRQTDPLYSLDLTDPTKPLVTGELKITGYSAYLHPLPDGRLLGVGQEADGQGRTEGVQVSLFDVRNPARPTRLDQWHLPSGWSAAEHDPHAFLYWPANGLVVLPVDTGLRLLRVSADRISEIGQVTHPTVTTHSDRAWRRPDVQRALMIGDVLWTVSEAGLRASDPATAQGLGWIPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4I5</accession>
    <name>F4F4I5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Creatininase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_09125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731614.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09125"/>
    <dbReference type="EnsemblBacteria" id="AEB42943">
        <property type="protein sequence ID" value="AEB42943"/>
        <property type="gene ID" value="VAB18032_09125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09125"/>
    <dbReference type="eggNOG" id="COG1402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_11"/>
    <dbReference type="OMA" id="VEWHGPH"/>
    <dbReference type="OrthoDB" id="984747at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="291" mass="30643" checksum="ED1B49E8267FB33F" modified="2011-06-28" version="1">MDELIERWKAEGGLLPITRVPGHALAAVAESADLAVLPVGAVEWHGPHLPLGTDLLLAEGFAGELATGTARAVLFPAAPYAACPGQTRPWPGTVALRPEIAVGYLSDVLTGIVEAGFPRLLVVNGHDANLSTVRAAMEWVSGRHLASLLLVNWFQLVGPDETGEIFGALPARGHGGAYESSAVLAFDPEAVHLSATPDLPPKPKLPTPYPYVLIESRPDPWQGWSGHVSLASEAAGQQIRHLAGARLREVIEAWLAAPLPSPPGTDQPGWSGRPTWSDRPDGSGRSDQAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4I8</accession>
    <name>F4F4I8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="9">PEPC</shortName>
            <shortName evidence="9">PEPCase</shortName>
            <ecNumber evidence="4 9">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ppc</name>
        <name evidence="11" type="ordered locus">VAB18032_09140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="4 9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09140"/>
    <dbReference type="EnsemblBacteria" id="AEB42946">
        <property type="protein sequence ID" value="AEB42946"/>
        <property type="gene ID" value="VAB18032_09140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09140"/>
    <dbReference type="eggNOG" id="COG2352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006557_2_0_11"/>
    <dbReference type="OMA" id="PWVFGWT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB42946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="929" mass="101716" checksum="E23DFDDB3E4CECA3" modified="2011-06-28" version="1">MVTDQHDHDGPDAALRADIRRLGTLLGQTLARQEGRPLLDLVEEIRAQVRTDAPAAARRLGGLDVTTGTKLARAFSTYFHLANITEQVHRARDLRRRRAVQGGWLDQAAKMISERGVPAEEIAAVARRLAIRPVFTAHPTEAARRSILSKLRAIADELDTETANAILYGASDEGPANRRLAELLDLMWQTDELRLDRPDPTDEARNAIYYLRDLYAEAAPQVLDDLAETLRTLGVETSPTARPLTFGTWIGGDRDGNPFVTPTVTREVLAIQHEHGLTATEAAMEELINEVSVSRRLRGVSLDLSASLAADLDALPEVAPRFRRVNAEEPYRLKARCVRAKLANTRARLRQGTPHVPGRDYRGSAELIADLELLRASLARNSGQLTAVGRLASTIRTVSAFGLHLATMDVREHAEKHHEVLAQLYAAVGEVDDYPSLSRLERTKLLADELTGRRPLSAADTPLSESARKTFDVFSTIREAQDRFGSEVIESYIISMTLGVDDVLAAVVLAREAGLVDVHSGRARIGIVPLLETPAELNAGGELLDELLSLPAYRALVAARGDVQEVMLGYSDSNKEAGITTSQWSIHRAQRALRDVAARHGVHLRLFHGRGGTVGRGGGPTHDAILAQPYGTLDGAIKVTEQGEVISDKYTLPALARENLELTVAAVLQATLLHTAPRQPAEMLERWDATMDVVSESAYRSYRSLVEDPDLPAYFWASTPTELLGALNIGSRPAKRPNTGAGLSGLRAIPWVFGWTQTRQIVPGWYGVGSGLAAAREAGLADVLAEMHRNWHFFRTFLSNVEMMLTKTDLGIARRYVETLVPKKLHPIFDKIEAEYELTRREVLAVTDSPDLLENSPVLQRTLAVRDTYLEPLHHLQVALLRQYRDSGAAGRAVVTAPGGRRAPNDGTALERALLTTVNGIAAGMRNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4J5</accession>
    <name>F4F4J5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">eno</name>
        <name evidence="13" type="ordered locus">VAB18032_09175</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731624.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09175"/>
    <dbReference type="EnsemblBacteria" id="AEB42953">
        <property type="protein sequence ID" value="AEB42953"/>
        <property type="gene ID" value="VAB18032_09175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09175"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_11"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="139"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB42953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="427" mass="45256" checksum="3290E5E4E7B85127" modified="2011-06-28" version="1">MATIEVIEAREILDSRGNPTVEVEVGLDDGTISRAAVPSGASTGAFEAIELRDGDKGRYLGKGVEKAVANIEDRIVDQLIGYEASEQRVIDQKMLDIDGTDNKAELGANAILGVSLAVAKAAAGSAELSLFRYLGGPNAHLLPVPMMNILNGGAHADSNVDIQEFMIAPIGAPSFREALRSGAEVYHALKSVLKKKDLSTGLGDEGGFAPNLPTNAAALDLIAEAVEKAGYRLGTDIVFALDVAATEFFSDGTYTFEGVAKTAEEMSEYYTKLADAYPIVSIEDPLAEDDWTGWQTLTAAVGDRIQIVGDDLFVTNPQRIARGIAEKAANAVLVKVNQIGSLTETLDAVDLAHRAGFKCMMSHRSGETEDTTIADLAVATGCGQIKTGAPARSDRVAKYNQLLRIEEELADAARYAGAGAFPRYRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4K6</accession>
    <name>F4F4K6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_09230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731635.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09230"/>
    <dbReference type="EnsemblBacteria" id="AEB42964">
        <property type="protein sequence ID" value="AEB42964"/>
        <property type="gene ID" value="VAB18032_09230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09230"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083279_0_0_11"/>
    <dbReference type="OMA" id="CVPPQNK"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="53"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB42964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="25555" checksum="590DDF002FDDF9B8" modified="2011-06-28" version="1">MVARAARATDLADLDAAVSDCFACPRLVQWREEVARTKRAAFRDQEYWGRPVPGFGDPAARIGILGLAPAAHGGNRTGRIFTGDRSGDVLFAALHRAGLANQPTSVAADDGLTLRHTRIFAAVRCAPPDNKPTPVERDTCAPWLHREVALIRPTLRVVVALGAFAWAAWWPVSRDVYGVAAPSPRPSFGHGAHWSGTAVPELLGCYHVSQQNTFTGRLTPGMLDDVFTEAKRLAGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4K8</accession>
    <name>F4F4K8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731637.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09240"/>
    <dbReference type="EnsemblBacteria" id="AEB42966">
        <property type="protein sequence ID" value="AEB42966"/>
        <property type="gene ID" value="VAB18032_09240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09240"/>
    <dbReference type="eggNOG" id="ENOG50339X8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1363783_0_0_11"/>
    <dbReference type="OMA" id="TRSERFN"/>
    <dbReference type="OrthoDB" id="2011443at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="21479" checksum="E7F00C96441A7121" modified="2011-06-28" version="1">MSSTSIDDLLSFSEDRPVQPEQRPAGWLRSVATFLGVAAASTVVLVAGLRAVGLRVSLLVLVAAVVTLLLVRRIVVLLAPPSRPTRSTSGAGGEEDGMYNWDARDALRTAVKRWEVPLEWSKSRPERFGEVVLPRLAELADERLRLKHGVTRESDPTRARVLLGDRLWMFLETPPRRTPSPRDLAVIVAELEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4L4</accession>
    <name>F4F4L4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC</name>
        <name evidence="3" type="ordered locus">VAB18032_15220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732821.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15220"/>
    <dbReference type="EnsemblBacteria" id="AEB44156">
        <property type="protein sequence ID" value="AEB44156"/>
        <property type="gene ID" value="VAB18032_15220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15220"/>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_0_11"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="OrthoDB" id="951261at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="2">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="333" mass="33809" checksum="7B0F671B21FC124B" modified="2011-06-28" version="1">MGIRVAVAGASGYAGGELLRLLAGHPEFDLVTATAHSQAGQRVDSVHPQLVGLDHTFAETVPETLAEADLLFLALPHGQSAALAAQLPTGVRVVDLGADHRLTDGDAWARYYGGPHAGAWTYGLPELPGQAERIAAATRVANTGCYAATITLALAPLIAAGVADPADVVVVAASGTSGAGRAAKTHLLASEVMGDLSPYKVGAHQHVPEIKQATGATGLSFTPVLAPMPRGILATVTARPTGSADPRAVLAQAYADSPFVHLLPEGRWPHTAATLGSNSCHLQATVDVDSGRLIVVAALDNLGKGAAGQAVQNANLMFGLPETTGLSPLGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F510</accession>
    <name>F4F510_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21995"/>
    <dbReference type="EnsemblBacteria" id="AEB45499">
        <property type="protein sequence ID" value="AEB45499"/>
        <property type="gene ID" value="VAB18032_21995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21995"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_4_3_11"/>
    <dbReference type="OMA" id="PRIVPCA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="125" mass="13560" checksum="E8503BD6671A494B" modified="2011-06-28" version="1">MLRIGELALRTGVSPRMLRYYDNQGLLPAERSTTGQRLFDVSAVEQVRSIRLLLDAGLPTRVIAELLGCIHEPGRLEPCAVPTLVEHLQAYDERIAALLSTRTALQGLIDSSSPTQGQLGAGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F533</accession>
    <name>F4F533_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_28221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735365.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28221"/>
    <dbReference type="EnsemblBacteria" id="AEB46715">
        <property type="protein sequence ID" value="AEB46715"/>
        <property type="gene ID" value="VAB18032_28221"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28221"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_11"/>
    <dbReference type="OMA" id="FHEAFDY"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312695" evidence="5">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="34863" checksum="57D760AD8A225485" modified="2011-06-28" version="1">MTFRTTPRVLATATAALLALTGVAACSTDTTSGGDPERVDVVAGFYPLQFLAERIGGDAVTVTNLARPGAEPHDLELNPRQVGQIIDAELIIFLDGFQPAVDTAIEQNGGDRAFDVAAVEPLLDATAGGHDHDHGDEHDHDDEHADEVSDGAKDPHVWLDPTRLATIGDKLAERLGAVDPDHADEYTQRAATLRTELEQLDTEFTEGLKTCQRREIVVSHTAFGYLTQRYQLEQIGITGLSPEDEPSPQRLAAVTEEAREHGATTIFFETLVSPKVAETIAREVGAQTAVLDPLEGLSTGNSGEDYLSVMRTNLQTLRTALSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F593</accession>
    <name>F4F593_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2344 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28521"/>
    <dbReference type="EnsemblBacteria" id="AEB46775">
        <property type="protein sequence ID" value="AEB46775"/>
        <property type="gene ID" value="VAB18032_28521"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28521"/>
    <dbReference type="eggNOG" id="COG5011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083579_0_0_11"/>
    <dbReference type="OMA" id="QPCAILR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="27536" checksum="18FF8D047ADFED2D" modified="2011-06-28" version="1">MKISKRPQPEGGQAPVVQRVRIRYAKRGPLRFTSHRDFARAFERALRRAGVPMAFSQGFTPHPKISYASAAPTGVASEAEYLEIGLREPVDPDALRLALDAALSPGLDVLDAVVATGSGLADRIEASRWRVELPQVDPEVLAKAVAAFSAAEEVQVERMTKQGRRTFDARAAVIAIDVGVASATPSEASAVPCAILELVVRQVTPSVRPDDVLSGLRVVAGLEPPVAPKVIRLAQGTLTAQGAIVDPLDADRDGATIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5C9</accession>
    <name>F4F5C9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_04475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04475"/>
    <dbReference type="EnsemblBacteria" id="AEB47977">
        <property type="protein sequence ID" value="AEB47977"/>
        <property type="gene ID" value="VAB18032_04475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04475"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_1_1_11"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="123"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="246"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="373" mass="39009" checksum="222D0EEDD081A255" modified="2011-06-28" version="1">MERDALAEAVAWTAKSLPNRPSVPVLAGVMLRVTDGTLQVSGFDYEVSSQVTVEVQGDADGAALVSGRLLAEITKALPGKPVDIAAVGAHLELVCGSARFTLPTMPVEDYPTLPEMPESAGTIDAAAFAAAVAQVAVAASRDETLPMMTGVRVELSGGTLSMLATDRYRLALREMEWNPDDPEISINALVPARTLNDTAKALGPVGGQVTMALSQGAAGEGMIGFSGGTRRTTSRLLDGANYPPVRSLFPASHNAEARVPVSTLIEVVKRVALVAERTTPVLLSFSADGLVVEAGGTEEARASEAMEATFTGEPLTIGFNPQYLIDGLANLGAQFAVLQFVDAFKPAVISPAGEDGELIGGYRYLIMPIRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5H7</accession>
    <name>F4F5H7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein arsr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731680.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09455"/>
    <dbReference type="EnsemblBacteria" id="AEB43009">
        <property type="protein sequence ID" value="AEB43009"/>
        <property type="gene ID" value="VAB18032_09455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09455"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063235_1_0_11"/>
    <dbReference type="OMA" id="PSFFCRR"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="253"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="35558" checksum="5C6775A5D07C327C" modified="2011-06-28" version="1">MLKIHFSGEDILRTRVAPAANPVWEAVLSLHLLPKRTGDPLLSGWRRDVLRDLYREENIDGLRLLLALNPPRGYFPDFLTPYESMDGFEAGMEAVRRTPVSLLHRDLTLVANTRSLPADAGALARGEPDALEQLTTAMGRYRELALGPYWTHVQAAVEADRARRARTLLDGGVKGLLTGLRPGVRWDSGILEIPGYPNSRELHLEGRGLLLVPSFFCADMPVALLDPELPPVLVYPVDRLGGLASDKPEKSTTALAALLGRTRAAVLAASDDGCSTGELARRLYISPAAVSQHTTVLRNAGLLASHRDRNTVLHTLTPLGRAILNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5V3</accession>
    <name>F4F5V3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734165.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22060"/>
    <dbReference type="EnsemblBacteria" id="AEB45512">
        <property type="protein sequence ID" value="AEB45512"/>
        <property type="gene ID" value="VAB18032_22060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22060"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_0_1_11"/>
    <dbReference type="OMA" id="ISERWNY"/>
    <dbReference type="OrthoDB" id="1919329at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="183" mass="20244" checksum="E75D4B66AD827131" modified="2011-06-28" version="1">MNHDEGPVEPTDALERLGAFAARDDWTATGWCRIERSLGLIGTRSAMLIVRELFYGGTRFDELARRTGLSEAVVAGRLKQLYADGIVDRRPYQEPGKRTRDEYLLTDRGRALFPIIVALVQWGELLGDDHRTGVELVHRGCEAPLSAHVRCAKGHDVPLGEAAARLKDEAYAAAARRQPHGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F610</accession>
    <name>F4F610_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_22345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734222.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22345"/>
    <dbReference type="EnsemblBacteria" id="AEB45569">
        <property type="protein sequence ID" value="AEB45569"/>
        <property type="gene ID" value="VAB18032_22345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22345"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OMA" id="WSNFLDP"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="277" mass="30146" checksum="A028B33306DFB525" modified="2011-06-28" version="1">MIGRWLGRFVVPAIFAAIFVAPLWFMLVGSLRPAGSPPPRTLELWPADPTTAAYTRLPELVPLARYLANSALVVALAVPLTVLVAALTGFGLRLLSGTARRRALLALLVVLLVPVTAVWATRFEVFRLFGAVDTYLPLLAPAALAVSPFLILLYAWSFGGIPDSQLQAARLEGAGWLTIWRRLAMPQVKPATLAVAVLAFTFHWSNFIDPLLYLTSGDRYTWPLGLRFLLLLNPTDWPLLMAGSVIATAPCVLVFLLAQRVLLADDPLAALRSKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4F696</accession>
    <name>F4F696_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28886"/>
    <dbReference type="EnsemblBacteria" id="AEB46848">
        <property type="protein sequence ID" value="AEB46848"/>
        <property type="gene ID" value="VAB18032_28886"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28886"/>
    <dbReference type="eggNOG" id="ENOG5031T1V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193475_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="62" mass="6427" checksum="82B74347DE4528D1" modified="2011-06-28" version="1">MARLGAAVSALGDIDVSAWPEDTLKEQLAELSAALVALDASLSRIAEGVRARGLRVEEPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6D0</accession>
    <name>F4F6D0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator PadR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09790"/>
    <dbReference type="EnsemblBacteria" id="AEB43076">
        <property type="protein sequence ID" value="AEB43076"/>
        <property type="gene ID" value="VAB18032_09790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09790"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_5_1_11"/>
    <dbReference type="OMA" id="ERIGDFW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="19002" checksum="17EBEAA54CA90534" modified="2011-06-28" version="1">MNGMAESGVNPTAAALLGLLHEGPMTGGQLMAAAERRLAPYWSMTRSQVYRELPVLAEKGLVRLGKPGPRMSQPYAITAAGKRTFSRWLAEDPGRDTIRNPIALRIAFGQLHSATQLKSLQAAANEYHTEALARVREQVKAARKEGDTYDASALEFAVAYHKAALSWLKNAPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6K3</accession>
    <name>F4F6K3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16125"/>
    <dbReference type="EnsemblBacteria" id="AEB44331">
        <property type="protein sequence ID" value="AEB44331"/>
        <property type="gene ID" value="VAB18032_16125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16125"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029927_0_1_11"/>
    <dbReference type="OMA" id="ARAFGKM"/>
    <dbReference type="OrthoDB" id="710201at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="34503" checksum="9C7F01287D7134E0" modified="2011-06-28" version="1">MQVPNRIEQPHVEALRRSITLFEDWDHRYGGGLARAAMAGQLEWACRAIRQASASPAVRRQWLSTAARLGDVVGWACFDAGEDAGTTRGYFVRSIQLATEAEDVQQRAHTVTSLSRRLTYSGKAKESLQIVGLARSGWRDLPPLGRAVIGIVEARAYASLRDAEECRRAVGLCDEHFDASPADGAYDPTWGYYADLGQILGDAGHAMCDLALTANDPALTDATITRLHAAYELHPGTVARSRALTMIRIACLQAHQGNVAAALPSARAGCTDAAGVYSSRLRDDVRVLAHMLENVDAEPDLKDDLVAVRAQLSGVAASQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6N3</accession>
    <name>F4F6N3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-N-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_16275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733021.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16275"/>
    <dbReference type="EnsemblBacteria" id="AEB44361">
        <property type="protein sequence ID" value="AEB44361"/>
        <property type="gene ID" value="VAB18032_16275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16275"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_2_0_11"/>
    <dbReference type="OMA" id="EPYICGN"/>
    <dbReference type="OrthoDB" id="620389at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="307"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="508" mass="55746" checksum="59D549DB8AE57F6F" modified="2011-06-28" version="1">MTTTTTAVIDLDLPGATIRRHVYGHFAEHLGRCIYGGFWVGEDSPVANVRGIRSDVVEALRAISIPNLRWPGGCFADDYHWRDGIGPRESRPRMVNSHWGDVVEDNAFGTHEFMDLCELLGADPYVSGNVGSGSVAEMSDWVEYLTRADDSPMAALRRANGREKPWRVPFWGLGNEAWGCGGNLRAEQFASLARQYATYCRNHGGNLLYRIAAGANEADLHWTETLMRSFDDLAADPAGSAGPFQAVSLHYYTMAGSWSDKGDATGFSTDEWYATMARARRMEELLTRHSTVMDRYDPHRKVGLVVDEWGTWWNVEKGTNPGFLYQQNTLRDALVASVHLDAFHRHAERVVMANIAQTVNVLQAMILTDPDTGALVLTPTYHVFAMNTGHHDAAALAVHLRDVETRAVDATELPLVSASASVKGDTALVSLSNLDAETDRTLVLDLRGRDVVGHTARVLTATALDAHNTPEQLDAVAPTDHAGVGPHPRGLEVDLPAHSYVTVALELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6S1</accession>
    <name>F4F6S1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734248.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22480"/>
    <dbReference type="EnsemblBacteria" id="AEB45596">
        <property type="protein sequence ID" value="AEB45596"/>
        <property type="gene ID" value="VAB18032_22480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22480"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="VRQADRY"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017780">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03410">
        <property type="entry name" value="urea_trans_UrtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="230" mass="24459" checksum="2FA4BBE6584B396A" modified="2011-06-28" version="1">MFSLRGVHAGYGRSRVLHGVDVQVPGDGVATVLGHNGAGKSTLLRVAAGLLRPTAGQVEWDGEDITRLAPHQRVARGIAYVPQGQQCFPHLTAAENLRLVADGRRDGAAATAEVLDLFPALQPLLRRRAGLLSGGQRQQLAIARALITRPRLLMLDEPTEGIQPSVVAEIQDRIVALIAQTGFSVLLVEQHLGFALRVADRYHVLESGRVTSAGEGGGDAELTVREALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6T0</accession>
    <name>F4F6T0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734257.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22525"/>
    <dbReference type="EnsemblBacteria" id="AEB45605">
        <property type="protein sequence ID" value="AEB45605"/>
        <property type="gene ID" value="VAB18032_22525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22525"/>
    <dbReference type="eggNOG" id="ENOG50346SA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2107987_0_0_11"/>
    <dbReference type="OMA" id="CPVRIEG"/>
    <dbReference type="OrthoDB" id="1686242at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="115" mass="12192" checksum="A9FA2AF80547907C" modified="2011-06-28" version="1">MSGLGEVVAERRIVVIDPEGVTSELVVRLGKPDPDPLSHHGDWGCPFQVEGLGEDSVQTAYGVDSLQALLLAAYRVRLLLAEHAEQTSARLDWLGQPDFGLRVDPGPAGPPASPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6U8</accession>
    <name>F4F6U8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, trar/dksa family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_22615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734275.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22615"/>
    <dbReference type="EnsemblBacteria" id="AEB45623">
        <property type="protein sequence ID" value="AEB45623"/>
        <property type="gene ID" value="VAB18032_22615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22615"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_3_4_11"/>
    <dbReference type="OMA" id="CAKPIPA"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="104" mass="11487" checksum="F810A5F1F6FE32DF" modified="2011-06-28" version="1">MSTDTFDQKWLTDLRTTLTHEFEAQTARLTELTADTGDPAEAHTNAALIAATRQSLAQITDALRRMSSGSYGDCEKCGTAIPRERLEILPQARFCVPCQQKQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F731</accession>
    <name>F4F731_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735544.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29121"/>
    <dbReference type="EnsemblBacteria" id="AEB46895">
        <property type="protein sequence ID" value="AEB46895"/>
        <property type="gene ID" value="VAB18032_29121"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29121"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151893_0_0_11"/>
    <dbReference type="OMA" id="HEGAHTT"/>
    <dbReference type="OrthoDB" id="1805706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="122" mass="13668" checksum="2204013626F39145" modified="2011-06-28" version="1">MAEATVRFFEDLDQQGYEPLLAKLSGTLRFDLHEGPQTMHWLVRIDRGQIRISREDMEADAVVGTSPGLFEDLVTGRENGLAALLRGDMTITGDARLIVQLDRIFPGPPHSVGPHRYRKGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F794</accession>
    <name>F4F794_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731823.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10170"/>
    <dbReference type="EnsemblBacteria" id="AEB43152">
        <property type="protein sequence ID" value="AEB43152"/>
        <property type="gene ID" value="VAB18032_10170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10170"/>
    <dbReference type="eggNOG" id="ENOG502ZBUP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092058_0_0_11"/>
    <dbReference type="OMA" id="FRRWIPD"/>
    <dbReference type="OrthoDB" id="2012009at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="233" mass="25070" checksum="F0329C7E5628834E" modified="2011-06-28" version="1">MTAYGEPTVVGDGVGELVVLWGGFPIVGAAAGGLLAAGAGWVTGLAWAPAQGLFRLVDGLPDGYAMGGGVGLGVLAGLVIAALGTADRVLVTVDGTRIRLRHGDTEQEVPRSRTRVAFVDGKDLVLLDGDAGELVRQRSDLPADRLAAALQEHGWPWADTDPHRDEYRRWVPDLPGLPTGADALLRARQEALERDRRDEARELRAELGRYGVVVRDDAKRQYWRLTRSGRPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7A9</accession>
    <name>F4F7A9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731838.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10245"/>
    <dbReference type="EnsemblBacteria" id="AEB43167">
        <property type="protein sequence ID" value="AEB43167"/>
        <property type="gene ID" value="VAB18032_10245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10245"/>
    <dbReference type="eggNOG" id="COG0748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114921_1_1_11"/>
    <dbReference type="OMA" id="GHEWRPG"/>
    <dbReference type="OrthoDB" id="1622823at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="145" mass="16370" checksum="CFA4F727741469EC" modified="2011-06-28" version="1">MSTSEQVLDSPSGWVAEHINRYVATDGDKGHEWRPGVFTLLLTTRGRRSGKLRRTALIYGRDGEAYVIVASQGGDPRHPAWYLNLEADPTAQVQVGADRFTARARTATPEEKARLWPMMTDIWPAYDDYQAKTERDIPVVVLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7B7</accession>
    <name>F4F7B7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731846.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10285"/>
    <dbReference type="EnsemblBacteria" id="AEB43175">
        <property type="protein sequence ID" value="AEB43175"/>
        <property type="gene ID" value="VAB18032_10285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10285"/>
    <dbReference type="eggNOG" id="COG3416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142193_0_0_11"/>
    <dbReference type="OMA" id="WAPAQDY"/>
    <dbReference type="OrthoDB" id="2054420at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="16872" checksum="20B68937FD7FD6FB" modified="2011-06-28" version="1">MGRRTFLAAAGWLATAVLATLIGVAAIQLVGESLTGTPGGVRSQQEVARALAEPPPVVPSANPTAAPSNPSGTPSNPSGTTSAPGTASPSVEAGSRRSFTSPGGSVVAECVPGGVYLVSWTPRQGYRVDDYDRGPDDDAEVTFVGPSGEHELSLRCQGGVPVLETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7C9</accession>
    <name>F4F7C9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 9">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_10345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731858.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10345"/>
    <dbReference type="EnsemblBacteria" id="AEB43187">
        <property type="protein sequence ID" value="AEB43187"/>
        <property type="gene ID" value="VAB18032_10345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10345"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025154_3_0_11"/>
    <dbReference type="OMA" id="VYFPGSP"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="11">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="137"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="428" mass="45781" checksum="2AA829B2A9F24923" modified="2011-06-28" version="1">MHTLRPALLTDHYELTMVSAALRDGTAHRHCVFEVFSRRLPAGRRYGVVAGTARLMELIREFRFDPAEIDFLRRTGVVDEPAAAWLADYRFTGDIDGYAEGELFFPGSPILTVSGTFAECVVLETVVLSVLNHDCAVAAAAARMVTAARGRALIEMGSRRAHEEAAVAAARAAYLAGFQFTSNLAAGQRYGIPTAGTAAHAFTLLHDDERTAFASQVATLGSQTTLLVDTYDISQGIRNAIEVAGPELRAVRIDSGDLAVIAQQSRELLDSLGATETKIIVSGDLDEYAIAALAAEPVDMYGAGTSVVTGSGAPTAGLVYKLVEVEGRPVVKRSEQKATIGGRKVAVRRHKPTGTATEEIIVPQGVPDRHPNDRLLQRSYLTGGEAVALPTLDESRDHLRQCLISIPWEGLKLSAGDPAIPVTVVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7E9</accession>
    <name>F4F7E9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Luciferase/monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">abyE</name>
        <name evidence="3" type="ordered locus">VAB18032_16410</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733048.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16410"/>
    <dbReference type="EnsemblBacteria" id="AEB44388">
        <property type="protein sequence ID" value="AEB44388"/>
        <property type="gene ID" value="VAB18032_16410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16410"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_9_0_11"/>
    <dbReference type="OMA" id="VICAETM"/>
    <dbReference type="OrthoDB" id="1003376at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEK75507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="335" mass="35589" checksum="9A5CF4363385D6BD" modified="2011-06-28" version="1">MTDTPPVSVLDVVPVWSGSTATRALRDSVQLAVEVERLGYTRYWVAEHHNTPCLATATPPVLVGALLAATSTLRVGSGGVLLPNHPPLVVAEQFGTLAALYPGRVDLGVGRAPGTDAATARALRRAPDGADQFPTELAELIDHFGPAPRPRQITAVAAAESEVPVWILGSSPGSARLAGSLGLPYAFAHQINPTLTATALQLYRKSFRPSAHLADPHAILSAVVVVGENDEHAERLIAPYLLGQIGHRTVGRLDPFPNAAQAQQHSYTDAERAFVAERITSQIVGGPETVRERVQRLHAETGANELMALTILPELEDRVRSYALLADAVRASIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7U8</accession>
    <name>F4F7U8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_23175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734387.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23175"/>
    <dbReference type="EnsemblBacteria" id="AEB45735">
        <property type="protein sequence ID" value="AEB45735"/>
        <property type="gene ID" value="VAB18032_23175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23175"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_11"/>
    <dbReference type="OMA" id="GIVMVWF"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB45735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="668" mass="74194" checksum="B252D9DB0E4C3531" modified="2011-06-28" version="1">MPKRVPTETGQDRGPAILAPARFGGYPGSLNKSLPGSKLLRFLATTDHKQIGLLYLMTSFGFFVVAGIEAMLIRAELARPGMQFLAPEQYNQLFTSHGAVMLLLFATPAAFGFGNYIVPIQIGAPDVSFPRLNALAYWLYLFGGLMVIGGFLTPQGSADFGWTAYTPLSTAQHSPGVGANMWVIGLVVSGLGTILGAVNLITTILTLRAPGMTMFRMPIFTWNMLFTSVLVILVFPLLAAALLALSADRLLDAHVYSPATAGPMLWQHLFWFFGHPEVYIIALPFFGIITEIIPVFSRKPLFGYTGLVLATAAITVLSMTVWAHHMFTTGQVLLPFFAILSYLIAVPTGVKFFNWIGTMWKGQITFETPMLFAIGFLVTFLLGGLTGVLLASPPADFHTHDSYFVVAHFHYVLFGTVVFALFGGFYFWWPKMTGRLLDERLGKLHFWTMFIGFHGTFLVQHWLGNEGMPRRYADYLPSDGFTTLNTISSIFSFVLGASTLFFIWNAWKSWRFGALVTVDDPWGFGNSLEWATTCPPPLRNFDRMPRIRSERPAFDAKYGELVSDLGRDLPQRTTKPPQGLRDELHREKHHRESPSAEGAHGAPEATAYHPAPQSGARPVEVPDPQNVRRPSFDDTDEPEDNPLGAERRSETDDDRWRHPRSGGDTPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F895</accession>
    <name>F4F895_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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    <dbReference type="EnsemblBacteria" id="AEB43256">
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_151362_2_0_11"/>
    <dbReference type="OMA" id="WPCGAAK"/>
    <dbReference type="Proteomes" id="UP000008308">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="12951" checksum="2BBE46DF403C66B3" modified="2011-06-28" version="1">MSGDGMPAVEAGRSGPDSLGHLPMRPLWLCRTCGQPWPCGRAKLNLLASYRDSSLSLFLYLAGLLHEAIDDLHRLDPRSTGDVRDLFERFLGWPARKAARRSVEADESASEKPEDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8B9</accession>
    <name>F4F8B9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
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        <property type="protein sequence ID" value="AEB43280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10810"/>
    <dbReference type="EnsemblBacteria" id="AEB43280">
        <property type="protein sequence ID" value="AEB43280"/>
        <property type="gene ID" value="VAB18032_10810"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="16493" checksum="2F5657BBD236EC6D" modified="2011-06-28" version="1">MTTTIAYDQLADLAGTDLGYTEYRTVTQDQVNLFADATDDHQWIHVDPERAKTGPFGAPIAHGFLTLSLAVPFWTELLEVKGVTTKVNYGLDKVRFPAPVTVGSRVRMRATIAEVTEVRGGYQIAVDQTIEIEGGTKPAVVARGLYRFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8R0</accession>
    <name>F4F8R0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_23525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734455.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23525"/>
    <dbReference type="EnsemblBacteria" id="AEB45803">
        <property type="protein sequence ID" value="AEB45803"/>
        <property type="gene ID" value="VAB18032_23525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23525"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_11_2_11"/>
    <dbReference type="OMA" id="WMAREGH"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="216"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="45479" checksum="CD64AE1E89AB1760" modified="2011-06-28" version="1">MRIGILSYHFPPEPAFIPGSLAEELAARGHEVRVLTGFPDYPGGHVYPGWRQRWRHETRSRNLTVRRVPRYSTGDGGVRPRMASWLSFAASAGLVGRRYLADVDVLYVHQPPATAFASATLLRLLGRIPVVLHVPDVWAEQAPDDTDDGRWAARVRAAMTRTYQAASAIAVSTPSLRDAVVAVGADEARVEVVLNWTDERIFRPAPAGSAARGLVRRDERCVVMHAGTIGARQGLETAVRAAAALQNTIDLVLVGSGAHERRVRGLAAELRADNIRFVDRRSPLDMPELYAAADYQLVMLRDLPALRSTVPDKLPAALSCAAPVVASAGGDTATLVERARAGLSCPPEDWASLADRFWLAAQIPPPARAEMGRRGREAYLREMSLPGGVDRIERLLREAAVGGSRGGADLSKPKLIRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F919</accession>
    <name>F4F919_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42047">
        <property type="protein sequence ID" value="AEB42047"/>
        <property type="gene ID" value="VAB18032_04605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04605"/>
    <dbReference type="HOGENOM" id="CLU_2235445_0_0_11"/>
    <dbReference type="OrthoDB" id="2176324at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="105" mass="11937" checksum="772FD5345BE762ED" modified="2011-06-28" version="1">MWSSRFKAIYDQRGGVELSGLWVARLNISTRTAQKIIQRHDITPDEVRAAVVCVEGLTYVWDEDPERGTRAIVQTFVRGRTTLVVLYDADDPLGDVYNLGSAYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9A8</accession>
    <name>F4F9A8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide oxidoreductase dcc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10920"/>
    <dbReference type="EnsemblBacteria" id="AEB43302">
        <property type="protein sequence ID" value="AEB43302"/>
        <property type="gene ID" value="VAB18032_10920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10920"/>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137436_0_0_11"/>
    <dbReference type="OMA" id="AWIVCLW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="164" mass="17268" checksum="A4EA0BFB0BC68E91" modified="2011-06-28" version="1">MSTHGPDRAGGMPDATTHGGGGIRYFTVLYDAHCPMCRAARGWLASRAQLVPLEFVPAGSAEARQRFPGLDHAATLRDITVVADTGAVYVGDGAWFACLWALAEYRATAERLAAPHLLPLARRVVAAASALRERVREAGPPSLDGPAGYGGPDDRPVCADDRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9B0</accession>
    <name>F4F9B0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10930"/>
    <dbReference type="EnsemblBacteria" id="AEB43304">
        <property type="protein sequence ID" value="AEB43304"/>
        <property type="gene ID" value="VAB18032_10930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10930"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_11"/>
    <dbReference type="OMA" id="EMGLPIW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="31"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="483" mass="49352" checksum="267C46785172F973" modified="2011-06-28" version="1">MRLDPGLRRLALGTLLAAYPGSTPPDWAVELVADGLAGHTLFGRNIDEPARVAASTAALRTARADVLVGIDEEGGDVTRLAHATGSPYPGNAALGAIDDEALTRDIHRAIGGELAALGITVNLAPTVDVNSTDDNPVIGTRSFGADPARVAAHSAAAVAGLQAAGVAACAKHFPGHGATVTDSHHELPTVDVPPEVLRRRDLPPFAAVIAAGTRAVMTAHIRVPALTGAAPATFSRAVLVDLLRQEYGFTGAVITDALEMKGAALAAGGIAPGAVRALAAGADLLCIGAKVDAGLVERVATEIVTAVGDGRLARDRVEQAAGRAAELAAWTRDTGPTTVAAADLGYAAARRAVRVEGSLAGLDHPLVVQVHARSTVVQGRVPWGLGPHLHGTELIEVVATEADPEELRRRAGNRPIVLVGRRLHQLPGGPELVAALAGTHPVAVVEMGWPARWRPTGTRAFVITYGASHANGLAAAEVLGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9M6</accession>
    <name>F4F9M6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase and related Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733259.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17510"/>
    <dbReference type="EnsemblBacteria" id="AEB44604">
        <property type="protein sequence ID" value="AEB44604"/>
        <property type="gene ID" value="VAB18032_17510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17510"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="OMA" id="PMAMGRE"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="31634" checksum="E3B480E7A1C4FD73" modified="2011-06-28" version="1">MSRAFGYRTFGGPEVQFYFDRPDPRPGDGEILIQVRAIGVARIDHMLRSGLVRALNGHLPFPQVMGMEAAGDVLAVGTGVTDITVGDAVFGFALSGAGTYAQTTLLPAANAARKPEALPYEWAATIPVSGTTALDGLDRLDLPEGSTLLINGIGGSTGQITAQLARARGLTVIGTGSDSKRAEAEALGVTFASYTVGDVVEQVRDVAPAGVDGLIDLVGGDSLRSVAALVTDARQLLSAADVAVSDLGGEYLPRRLDRASLETVAALMLNGTVDPRITRTFSFDQSAEALAAVETGHTAGKLVIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9N7</accession>
    <name>F4F9N7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733270.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17565"/>
    <dbReference type="MEROPS" id="S12.003"/>
    <dbReference type="EnsemblBacteria" id="AEB44615">
        <property type="protein sequence ID" value="AEB44615"/>
        <property type="gene ID" value="VAB18032_17565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17565"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_2_3_11"/>
    <dbReference type="OMA" id="GINISHY"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309180" evidence="1">
        <location>
            <begin position="29"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="417" mass="44175" checksum="9F8C3364522913FC" modified="2011-06-28" version="1">MFSTLRTRKIVAAGVMLAATIAVVPASAAAQPGPSAGRPDRVELRAALTAVPEAGVPGVLAEVRDGRHDWRAAAGQAYLTKPRPMQPQMRHRIGSITKTFVATTVLQLVDEGRLGLDDPVGRWLPDTVPGERGDQVTVRMLLNHTSGIGNYTNAMIDSYASINQMQVTTYAPADLVATGLAMPPTGAPGATFSYSNTNYVLAGLLIEAVTGNDAPAEVQRRILRPLKLTGTSFPGTDPTIRGPHSGAYFAPFGARDLSEFNMSWGWTAGEMISTTADLNTFFRALLDGDLLSPATLKQMLDGVPMLPGLPEAGTYGLGIYSLPTPCGEFLGHDGAVFGHLTYSLHSRDGTRQVSSGINISHYQVGLPDPHPFDIAWQTFLLTAMCPTSDVSSRSAEAVPQLPSVTRMPGNDAVVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Q5</accession>
    <name>F4F9Q5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734483.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23665"/>
    <dbReference type="EnsemblBacteria" id="AEB45831">
        <property type="protein sequence ID" value="AEB45831"/>
        <property type="gene ID" value="VAB18032_23665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23665"/>
    <dbReference type="eggNOG" id="ENOG5033THG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054507_0_0_11"/>
    <dbReference type="OMA" id="CAVWAGD"/>
    <dbReference type="OrthoDB" id="912211at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312832" evidence="2">
        <location>
            <begin position="42"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="422" mass="44502" checksum="1ADE621C3F9C8F36" modified="2011-06-28" version="1">MRRSPRSRRPSGNTRTKRLLAIGATLAVFGGVVAVTQISSAGDRRPHKQTRPVAAECVAPSPGATAPAARGATTTRTFQNGRWVTNHWGDGQQTIEECQETRSGGGAATGSLAVACPDVVSRLPQVPDRARAEVDRNLALLQTQITEADQRLAAEGNKGQGFINNAILGPLASKRRATLDRITIAIDRFGPRPRGLADLARCQARPVNNNNGGNPDNGNPNNGGGNNNGGNNGGNNGGNPNGLDVLANNCNNSRLQPHDGFQNGNRCISTAFGEVGAAANNPSLLITEFPQQINRNQGFAIRVSTRNLVRDRFLPAGQGGYYLESSLLNGEGLTRGHFHTACRMLNNTDEAPAPEPVPAFFVATEDGGGGRQPDSVVIQIPGLPESGTAQCAVWAGDGSHRIPMSERANQTPAFDAVRIQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA02</accession>
    <name>F4FA02_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ordered locus">VAB18032_00145</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735759.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00145"/>
    <dbReference type="EnsemblBacteria" id="AEB47113">
        <property type="protein sequence ID" value="AEB47113"/>
        <property type="gene ID" value="VAB18032_00145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00145"/>
    <dbReference type="eggNOG" id="ENOG5032RVG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044654_0_0_11"/>
    <dbReference type="OMA" id="CHVEDPD"/>
    <dbReference type="OrthoDB" id="1974660at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="13193" checksum="63B64F5A94A940D6" modified="2011-06-28" version="1">MSLALAPLDLNVEIEANLPCRKFDPDLWFSDSPTDLDVAKTLCGDCPLRVECLAGAVERAEPWGVWGGEIFERGAVVPRKRPRGRPRKEDLARDAALRVEAEARLAANGLATSRNAVRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA21</accession>
    <name>F4FA21_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735778.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00240"/>
    <dbReference type="EnsemblBacteria" id="AEB47132">
        <property type="protein sequence ID" value="AEB47132"/>
        <property type="gene ID" value="VAB18032_00240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00240"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_1_0_11"/>
    <dbReference type="OMA" id="SWTDAIN"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="170"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="357" mass="38422" checksum="2A01CBF4F116A09D" modified="2011-06-28" version="1">MENPLTPEVLADPVALTRALVDIESVSLNEKAIADCVEEVLRAVPHLSTYRHGNTVMARTDLGRGSRVVLAGHLDTVPLNNNFPSTMRGDLMYGCGTSDMKSGVAFALHLAVTLAEPRHDVTYFFYEAEEIESRYNGLTLVSAAHPEWLQADFALLLEPTHGVVEAGCQGTMRATVVTTGVRAHSARSWHGVNAVHAAGDVLRRLAEYQARRVTIDGCEYREGMNAVRIHGGVAGNVVPDRCEIEVNYRFAPDRTPAEAEAHLREVLAGYELAVTDCAPGALPGLDAAPAREFLATVGAAPIGKLGWTDVARFAALGIPALNFGPGDPNLAHHPDEHVEIGKIREGAAILHRWLANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAH2</accession>
    <name>F4FAH2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11415"/>
    <dbReference type="EnsemblBacteria" id="AEB43399">
        <property type="protein sequence ID" value="AEB43399"/>
        <property type="gene ID" value="VAB18032_11415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11415"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_11_8_11"/>
    <dbReference type="OMA" id="PVACGGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="180" mass="19446" checksum="6B99A534FCF69133" modified="2011-06-28" version="1">MVDHCRRLSAQVGGGDGSLRSYASLVHEIEIHVVPFDSPVAQRLITSALADLGARYGGDGDETPVDAREFTPPHGTFLVAHLDGQPVGCGGWRSHGTDGETAELKRMYTAPQARGRGVARTVLAAVERSAREQGRKRLILECGDRQPEAIAMYTSAGYERIPNFGYYADEPGCLSFGRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAJ7</accession>
    <name>F4FAJ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732094.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11550"/>
    <dbReference type="EnsemblBacteria" id="AEB43424">
        <property type="protein sequence ID" value="AEB43424"/>
        <property type="gene ID" value="VAB18032_11550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11550"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_11"/>
    <dbReference type="OMA" id="HQIEVNF"/>
    <dbReference type="OrthoDB" id="2021322at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="12653" checksum="95E78FD9725DB4C1" modified="2011-06-28" version="1">MEGLDMKLVTAVIKPHQLDAVKEALHALGVAGLTVSEVQGYGRQKGHTEVYRGAEYTVEFLPKIRVEVLTDEIDVEKIVDAVVGAARTGKIGDGKVWVTGVEEVVRVRTGERGLDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAN7</accession>
    <name>F4FAN7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_17750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733307.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17750"/>
    <dbReference type="EnsemblBacteria" id="AEB44652">
        <property type="protein sequence ID" value="AEB44652"/>
        <property type="gene ID" value="VAB18032_17750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17750"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_5_11"/>
    <dbReference type="OMA" id="RIPMIGG"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="390" mass="43866" checksum="F7F43D0A99C4FCED" modified="2011-06-28" version="1">MDFGLSDEERAIRDTARDFITREVMPLEQELLRRERAHQPGLEPSELRELQLKAKKFGFWGLATPQEYGGMDLPAVMQSLIWTEIGRTFVPFRFGGEADNILFYATEEQRQEFLLPTIAGDRNSCFAITEPGAGSDAANIRFRARRDGDDWILNGEKTFITGGNEADFAIVIAVTDPERGARNGGATAFLVDRSMGWRSEFIPTMGEGGPASLFFDDVRVPHRNILGEEGQGFALAMQWIGKGRYTIPSHAVGIAERALRMAIDHANTRETFGTKIGTNQAIQWMIADSETELEAARWLILRAAWTVDAGMDPRHASSMAKLYGAGMVNRVVDRVMQIHGGMGYTRELPIERWYRQVRLYRIFEGTDEMQRLIISRDLLRGYTKLGGHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBJ5</accession>
    <name>F4FBJ5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732126.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11715"/>
    <dbReference type="EnsemblBacteria" id="AEB43457">
        <property type="protein sequence ID" value="AEB43457"/>
        <property type="gene ID" value="VAB18032_11715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11715"/>
    <dbReference type="eggNOG" id="ENOG5031NC1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137804_0_0_11"/>
    <dbReference type="OMA" id="EAYANHY"/>
    <dbReference type="OrthoDB" id="2001311at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="161" mass="16779" checksum="ADBD1A415C638E5F" modified="2011-06-28" version="1">MTDTSAPTTAARKPLGSTVRLLSILVIIAGLVMLAAGATTWFVVQSQLADERITVSDDADNFAGKQIKGPFTAYAEAEVIEKHALEASGGKTYAELDREDPNRQVVMTGSFLRSSLFTSVVSFGVAALAMGIGVVLALIGYALLAVSRQLNAITPASSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBU1</accession>
    <name>F4FBU1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733396.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18195"/>
    <dbReference type="EnsemblBacteria" id="AEB44741">
        <property type="protein sequence ID" value="AEB44741"/>
        <property type="gene ID" value="VAB18032_18195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18195"/>
    <dbReference type="eggNOG" id="COG0647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_4_2_11"/>
    <dbReference type="OMA" id="PNPYFFE"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="27104" checksum="2E99E10BDDC34C85" modified="2011-06-28" version="1">MTAIRAVLLDLEGTLYANARVIDGASDAIAELRERGLGVRFLTNTDSKTAERIRTELAGYGLSVAADELFTPVVAAERLLTAAQARTFALLSRELTALMPTVAAVGPYTHVLVGDCRETLDYPALDEAFRAVRAGAELVALQRGRYFKRADGDHVDTGAVVAAIEYAAGVTARVLGKPSPDFFRLAATSLGVEATECLVVGDDATTDVAGGRAAGLGTVQVRTGKYADQRAEGLTGDADHEVDSVADLPALLRRLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBV2</accession>
    <name>F4FBV2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-(ACP) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733407.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18250"/>
    <dbReference type="EnsemblBacteria" id="AEB44752">
        <property type="protein sequence ID" value="AEB44752"/>
        <property type="gene ID" value="VAB18032_18250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18250"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309220" evidence="1">
        <location>
            <begin position="35"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="253" mass="24560" checksum="8ED632493C640545" modified="2011-06-28" version="1">MTGVAPAAGLLTGRRVVVVGGASGIGLATVRAAAAAGAAVAVLDADATGAADAAEQAQAAGATACAHPVDVTAEAQVSAALDAVAAELGGIDAVLHVAGVMRGQGTELADLPLELWQQVIAVNLTGPFLVAKHAVRHLGGGDGVLVLVGSKAGVLTGSGSVPYGASKGGLHGLALTLARHLGPQGIRVHTLCPGDIDTPLMRRSLDEARANGVNGAQVARIEAALGRPEDVASVLVLLASPASAGIAGTVYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC01</accession>
    <name>F4FC01_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734651.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24505"/>
    <dbReference type="EnsemblBacteria" id="AEB45999">
        <property type="protein sequence ID" value="AEB45999"/>
        <property type="gene ID" value="VAB18032_24505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24505"/>
    <dbReference type="eggNOG" id="COG2170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044848_0_0_11"/>
    <dbReference type="OMA" id="WAGRDTG"/>
    <dbReference type="OrthoDB" id="991285at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="383" mass="40889" checksum="BF7D04CD2F93C76D" modified="2011-06-28" version="1">MATEQRPGSTVPRIGVEEEFFVVDPDRGEVVPEAATVIDRARPALGARVGGEITKLHVEARTDPCRSLDELGAQLAEGRRAVQSAASSAGLRVIASASPVLGNAVPPPITEGPRQDRGNATFRGLHDELAICAVHVHVEEPDRDRAVLIGNHLRPHLPVLLALTANSPYWCERDTGYASWRSVTWGRWPVAGPPPFLTSAQQYDDHIAMLIEAGALVDHGTIFWDLRLSANHPTLEVRVTDVPVTAAESVALAALVRALVMVAGQAVDTGDEGPRPVPELLRLAYWRAARDGMGGHGVDVATGRLLPAAALADRLVRLVRPALDEAGDRQRVEDWLARLGTDGDGATRQRAAAAARGRLTDVVDEIIAQTAPGVLAEQEGTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC18</accession>
    <name>F4FC18_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734668.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24590"/>
    <dbReference type="EnsemblBacteria" id="AEB46016">
        <property type="protein sequence ID" value="AEB46016"/>
        <property type="gene ID" value="VAB18032_24590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24590"/>
    <dbReference type="eggNOG" id="ENOG502ZB9P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075044_0_0_11"/>
    <dbReference type="OMA" id="LPIAVWE"/>
    <dbReference type="OrthoDB" id="1684725at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025495">
        <property type="entry name" value="DUF4386"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14329">
        <property type="entry name" value="DUF4386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="235" mass="24552" checksum="B9CAA287B594CFE7" modified="2011-06-28" version="1">MDALRRTSLVAGGLYVLTFVSIPTVALYGPVRDSDFVLGATSETSVLVGSVLEVIVALACIGTAVVLYPVVKRQGQTRALGFVSVRILEAACIFIGVASLLTIVALRRQGVGAEAVVTGQMLVAFYDSVFLVSQSLIPAANALLLGTLLYQARLVPRVLPVLGLVGAPLLVVSDLCVLFGLWDRLSPVTAIGALPIAVWEFSLGVYLIVRGFRPSEITAGSAAAGTSVRDVEPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC64</accession>
    <name>F4FC64_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1205 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734714.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24820"/>
    <dbReference type="EnsemblBacteria" id="AEB46062">
        <property type="protein sequence ID" value="AEB46062"/>
        <property type="gene ID" value="VAB18032_24820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24820"/>
    <dbReference type="eggNOG" id="COG1819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_7_4_11"/>
    <dbReference type="OMA" id="EPSFRAC"/>
    <dbReference type="OrthoDB" id="1485440at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1205" evidence="2">
        <location>
            <begin position="214"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="444" mass="48282" checksum="07E74FE50FEF345E" modified="2011-06-28" version="1">MRVAFVVWPAPAHLYPVVPLAWALRSAGHEVYVASHPSIGDAVTGQGLPFAPLCAPDAMPHPLGPGGVWGRERADVGQITAALDLPVQDIGTWMTFSQFLLPTMWDFMPYKASPETPMPAMDGLVEFFRGWRPDLVIWDPCMPGAAVAARAVGARQARYTGPDHVGWSMDTFIRLAGDLGASRVDNPLVETVRPMAERYGVDVDRELLLGEWTINPMPSSINMPVDTRVLPVQWIPHVTQEAIPPWLYPVPERPRIAVSLGVSTRAYMAADWSHVGLLLDALGELDVEVVATLNDVQLAQVTRVPENVRLIDYFPLDQLMPTCSLLIHHGGLASMVTAAYSRVPQLVVDFLDLQIGVTTSEDGVVTGSRYPLAPVTGGFVTAHGAGEVLDLSKPGVDVIRDQVARVATEPAFREGAARLHEELMLSPTPGGIVPMLEQFAARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCG8</accession>
    <name>F4FCG8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligopeptidase b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730968.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05845"/>
    <dbReference type="MEROPS" id="S09.010"/>
    <dbReference type="EnsemblBacteria" id="AEB42295">
        <property type="protein sequence ID" value="AEB42295"/>
        <property type="gene ID" value="VAB18032_05845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05845"/>
    <dbReference type="eggNOG" id="COG1770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_0_2_11"/>
    <dbReference type="OMA" id="NMGAGHG"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="481"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="698" mass="77814" checksum="3CF2D5B347539DB4" modified="2011-06-28" version="1">MTTETPAPVAKRVPTERVHHDDIVVDEYAWLAAKDDPETIAYLDAENAWTEQRTAHLSGLRTELFEEIRRRTQESDLSVPTRKGGYWYYTRTVEGRQYGVHCRRAVRDGETTPPISADGAPLDGEEILLDGNLLAEGHDFFALGAFDVSPDGRFLAYSTDFSGDERFTLRIKDLVSGELLPDEIPGTFYGTAWSTDASVLFYVTVDEAWRPHRVWRHVIGTAAGDDVVVHAEDDERFWVGVELTRSERFILIDIASKLTSEVRVIPADNPTGEPAVIAPRRQGVEYSVEHHGHRFLILHNDGAEDFALAYASADTPGDWVPMIDHSPGTRLEAVDAFADHLVVTLRSNGLTGLRVLPLDGGDAHDIEFPEPLHTVGLDGNPEYRTDRLRLRYTSLIIPDSVYDYDLATQELTLLRRRPVLPGPDGQPYQPEDYEQQRDWALADDGTRVPISLVYRRGTPRDGSAPCVIYGYGSYEASMDPWFSVGRLSLLDRGVIFAVAHIRGGGELGRRWYDHGKMLAKKNTFTDFVACARHLAKTGWTAPDRLVARGGSAGGLLMGAVANLAPDAFTGIVAQVPFVDALNTILDPSLPLTVTEWEEWGNPLADPEVYAYMKSYTPYENVAPLDYPAILAMTSLNDTRVFYHEPAKWIARLRAVAPQGDYLLKTEMEAGHGGPSGRYDSWREEAFINAWILDRFGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCK9</accession>
    <name>F4FCK9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetate-CoA oxygenase subunit PaaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">paaB</name>
        <name evidence="1" type="ordered locus">VAB18032_06060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731009.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06060"/>
    <dbReference type="EnsemblBacteria" id="AEB42336">
        <property type="protein sequence ID" value="AEB42336"/>
        <property type="gene ID" value="VAB18032_06060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06060"/>
    <dbReference type="eggNOG" id="COG3460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141459_2_0_11"/>
    <dbReference type="OMA" id="PYRHPTF"/>
    <dbReference type="OrthoDB" id="2083684at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009359">
        <property type="entry name" value="PaaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038693">
        <property type="entry name" value="PaaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06243">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030200">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02157">
        <property type="entry name" value="PA_CoA_Oxy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="95" mass="10654" checksum="2541F2EEDEB43121" modified="2011-06-28" version="1">MSQHTTPLWEVFVRARRGLAHTHVGSLHAPDAEMALRNARDLYTRRQEGVSIWVVPASAITASSPDEKDAFFDPAADKIYRHPTFYEVPDGVAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCN9</accession>
    <name>F4FCN9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase/mu-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732202.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12095"/>
    <dbReference type="EnsemblBacteria" id="AEB43533">
        <property type="protein sequence ID" value="AEB43533"/>
        <property type="gene ID" value="VAB18032_12095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12095"/>
    <dbReference type="eggNOG" id="COG2423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_2_1_11"/>
    <dbReference type="OMA" id="HKNEIAP"/>
    <dbReference type="OrthoDB" id="1193876at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="309" mass="31627" checksum="E3DAED2B57EA3DEB" modified="2011-06-28" version="1">MTLLISDPQVAAALDAPATVDAMRRALLAAYDGRLVAPPRAAAPLGGGRMVLTAGHLTGRWYGYRSYDTFGHPGAEQVVVLHDGQTGAVRAVAVGEELGSRRTGGLGGVAVDALARPDAGTLGVIGAGGQAWTQVWAAAAVRPLREVTVFSRSAARRTAFADRVRAELGVPARAVDTARAAVRDRDVVVLATTSPTPVLDAADLAPGTHVNAVGFKQRDRAEFGTDLLDAAAVLVTDSPAQAGAYVPPMLAAEAPYASRLRDLGAVLAGAAPGRTDADQVSVFCSVGLAGTEVFLLDQVVRALAPAVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCX3</accession>
    <name>F4FCX3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ricin b lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18515"/>
    <dbReference type="EnsemblBacteria" id="AEB44805">
        <property type="protein sequence ID" value="AEB44805"/>
        <property type="gene ID" value="VAB18032_18515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18515"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516592_0_0_11"/>
    <dbReference type="OMA" id="KWEWIES"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307805" evidence="2">
        <location>
            <begin position="45"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="421"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="545" mass="57439" checksum="044D7AF98AD1CD89" modified="2011-06-28" version="1">MTTDLVRKTFSFGRMPRKLLAALLAALAVLSAVVATINWGVASARDDTVIGTKVTDRQFNAIVAAARSCPMLTPARIAGQLMAESGLDNRARDTASGGRGIAGLDDEDWKTWKPWPDARRSDISANVLALAHQMCDFSGQLRLAGITGDQWRVAVAAFHAGLPAVTRANGVPADAVEYVDLVSGYAGYYGQLKQFGGPGVPASTAPPASDTKGVPAPYVPLVVTAGTVCEQVTPAMVAAQVMALSGFDPHRLGPAGQRGIAQFLPEVWRSYGPSRGSAWDPETAIPAVGATMCALIDELSKLDGDPYLLALAAYRNGPTAVRQSGGSFDQPTETFLRAVKALTDLYVLDTRLARPAPSADPTTAPPSSQAPDPEASEPQPSSSAKPSSAPPKSRNTAPSEPDEAKPTTTAPKTTAPKPERPSGAKQIFHPRTGLCVSSGSTGDGTRLVLRSCQEDPSQWWVVRDDGTIRSRGLCMDIAWGDSADGTAIQVAICSGNPAQSWRINDKGGIISTLNGKSVDVEMGAKDKPLELWIYVGNAEQTWKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCX8</accession>
    <name>F4FCX8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18540"/>
    <dbReference type="EnsemblBacteria" id="AEB44810">
        <property type="protein sequence ID" value="AEB44810"/>
        <property type="gene ID" value="VAB18032_18540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18540"/>
    <dbReference type="HOGENOM" id="CLU_1626369_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="17730" checksum="146E91B9D7894C77" modified="2011-06-28" version="1">MVTPPSRHQEAARGLSSRRPTRSGPVPSSEVVAQAAALTSVRHVHTDDSWMDQPQLRQADALSSERDRAWGRVNQARGLAAKEYLDHRATPADHPAAPTESRERNWTAADHARWRRLALAAESGPGHTTAARLTSVRGVGARSRPVAPPVLGGSGRRYQARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD91</accession>
    <name>F4FD91_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/lc7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734773.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25115"/>
    <dbReference type="EnsemblBacteria" id="AEB46121">
        <property type="protein sequence ID" value="AEB46121"/>
        <property type="gene ID" value="VAB18032_25115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25115"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_0_1_11"/>
    <dbReference type="OMA" id="YEMTVLV"/>
    <dbReference type="OrthoDB" id="1635683at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="14750" checksum="96DFE5F83D176AF4" modified="2011-06-28" version="1">MTTLSQEARDLSWLVSGFAERVPGVAHAVVVSSDGLLVAISDHLPRDHADKLAAVTSGLMSITAGAAQMFDGDVVKQTVVEMGRGYFLVMQIRDGSILATLAAADADIGVVGYEMARLAKQAGEMLTPALRAELQQALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDN5</accession>
    <name>F4FDN5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF559 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06370"/>
    <dbReference type="EnsemblBacteria" id="AEB42398">
        <property type="protein sequence ID" value="AEB42398"/>
        <property type="gene ID" value="VAB18032_06370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06370"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052626_3_1_11"/>
    <dbReference type="OMA" id="WLTVHES"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="217"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="288" mass="32242" checksum="68B9E6E0529AE2E2" modified="2011-06-28" version="1">MLSLDQARRYLSPKAIRHRVDVGRWRQVHRAVYVTHNGPIVPAQLPWIGVLCAGPAAVLGGLSAARAWGLRRYDDKFVHILLPANHQTRSMPPGVRVHRTTLLPAADILDVGQPRRTMPARSLVDAAQWAPSDQEARAIIAAGFQQRLVGGDDVRQVLDRLPRARRRALIAQTATDAVGGAHSLPELDFLRLVRRAGLPEPTRQAVRHDATGRRRYLDALFEEWRVHVEIDGSQHLDPATAWADMRRQNDLWRSGDRVLRFPAWAIRHHPADVIAQLRAALLAAGWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDR3</accession>
    <name>F4FDR3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ordered locus">VAB18032_06510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731099.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06510"/>
    <dbReference type="EnsemblBacteria" id="AEB42426">
        <property type="protein sequence ID" value="AEB42426"/>
        <property type="gene ID" value="VAB18032_06510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06510"/>
    <dbReference type="eggNOG" id="COG1273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048975_1_1_11"/>
    <dbReference type="OMA" id="IRYRKVC"/>
    <dbReference type="OrthoDB" id="1724780at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="52"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="339" mass="36782" checksum="21A29BF69D2D097C" modified="2011-06-28" version="1">MRAIWKGAVSFGLVSIGVKLYSATEEKDIRFHQVHREDGGRIRYKRTCQVCGEEVSYDDIAKGYDIGGGEMVILTDEDFADLPLTTSHAIDVLEFVPAEQVDPILYNKAYFLEPEGTATKPYLLLRDALTDSERVAIVKVALRQREQLATLRVRDGVLLLNTMLWPDEIRKPDFGFLDEDLKIRPPELAMATSLIDSMAGDFHPDEFTDDYRAALQEVIDAKVEGREVVQPEEAEEAPAAAVDLMAALKASVERARAARGEAPAGGGAGEPTPITSARSAQQKKAAAKAPAKKAATRKAAPKKAEAAKKTEGTKKAAPKAAEKKAAKKAAPKKAARKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDX2</accession>
    <name>F4FDX2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Benzoylformate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_12695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12695"/>
    <dbReference type="EnsemblBacteria" id="AEB43653">
        <property type="protein sequence ID" value="AEB43653"/>
        <property type="gene ID" value="VAB18032_12695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12695"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_11"/>
    <dbReference type="OMA" id="CGVEVCF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050695">
        <property type="term" value="F:benzoylformate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="191"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="387"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="529" mass="55356" checksum="4A1B5D6DB55A08CE" modified="2011-06-28" version="1">MASVRDVTFELLRAHGLTTIFGNPGSNELPFLAGLPDDFRYLLGLHEGVVLAMADGYAQARRGPALVNLHAAAGTGNAMGQLTNSVYSHSPLVVTAGQQVRSTVGQEVMLANVDAAALPRPLVKWSSEPASAEDVPRTISQAIHTATLAPQGPVYVSVPYDDWRAESSVEARHLLSRTTVTAAALTTPQLTELAAMLDRAERPVLILGPDVDAVAANDHAVALAEALAAPAWIAPSASRCPFPTRHPAFRGVLPAGVKAISDLLAGHDLVLVVGAPVFRYHQYDPGRYLSEGTRLVHLTVDPGEAARAPMGDAIVCDLADTLARLTAAVTLGRRAALVPLPPIPAPRSGSASRLHPEEVFAVLRDTAPADTVWVTESTSTTGAFWAQADLREPGSYYFPASGGLGFGLPAAVGVQLADPDRQVVALVGDGSANYGITALWTAARYRIPVIFVILRNGTYGALRWFAQVLAAGEAPGLDIPDIDFTALAAGYGVTGVTVASRTALVEAVTDALAAGEPRLIQVDTDLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDX7</accession>
    <name>F4FDX7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732326.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12720"/>
    <dbReference type="EnsemblBacteria" id="AEB43658">
        <property type="protein sequence ID" value="AEB43658"/>
        <property type="gene ID" value="VAB18032_12720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12720"/>
    <dbReference type="eggNOG" id="COG0349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042387_3_0_11"/>
    <dbReference type="OMA" id="FMRVDTF"/>
    <dbReference type="OrthoDB" id="1462689at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="260"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="438" mass="47841" checksum="89F17BE8A2FA67C2" modified="2011-06-28" version="1">MTDEPPLRRRTAASRTGNDIETPPSARPEPSDAGTESTGGESVPLTAPREGTPEPVTVPEQLAEVVARFAAGSGPVALDAERASGYRYSQRAYLVQLRRSGAGTALIDPLPLPDLSALDAVIADTEWVLHAANQDLPCLAELGLRPRRLFDTELAARLAGFERVGLAALTEQLLGYSLEKHHSAADWSSRPLPESWLTYAALDVELLTDLRDALDAELTRQGKSQWAEEEFAALVQAGTRPPRVRAEPWRRTSGIHRVRGARAQARVRSLWYARDQIAARRDSAPGRVLPDSAIVAAAELDPKDEKTLLTLPGFGGRSVRRLARTWLAALDDARQLPDEDLPVTPTVEGPPPPHRWAERDPAAAARLARSREVVLRLAGEHNLPPENLISPDTVRRLAWQPPEEITEATVADALRTLHAREWQITLLLPALAQALLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE22</accession>
    <name>F4FE22_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_18945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18945"/>
    <dbReference type="EnsemblBacteria" id="AEB44891">
        <property type="protein sequence ID" value="AEB44891"/>
        <property type="gene ID" value="VAB18032_18945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18945"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="ADQCNRI"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="29123" checksum="508AD3A3896020D8" modified="2011-06-28" version="1">MVSTDDALLRIVDLGKSYRARERTVDALAQVDLTVDNGEFVAVVGPSGCGKTTLLKIIAGLLPATTGDVFLAGRRVTEPPADLGVVFQEYGRSLFAWKTVRQNVELPLRSRGVGRAERRELVAEALDAVGLGQAADAYPWQLSGGMQQRVAIARAVAYRPRLLLMDEPFSAVDAQTRGDLEDLLARLWRRYAMTVLFVTHDIDEAVYLGQRVVVLGASPAGVIAGFPIDLPAERDQLGTRSSARFGELRAQVYAQVRRTPHLEEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE56</accession>
    <name>F4FE56_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733580.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19115"/>
    <dbReference type="EnsemblBacteria" id="AEB44925">
        <property type="protein sequence ID" value="AEB44925"/>
        <property type="gene ID" value="VAB18032_19115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19115"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1893817_0_0_11"/>
    <dbReference type="OMA" id="IVHHHAE"/>
    <dbReference type="OrthoDB" id="1887557at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13769" checksum="A768BD8C16DE5E61" modified="2011-06-28" version="1">MSIDELSTTISDMYRSLGDRPAFDAHLHPDLTIWESDADDLLTGLAALDALRDTRAAAATGPAPVSVAPEQVRAESWGDTGLVRYVLRARFADDRPDTCFRVTDVLRRDDTGWRIVHHHAEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE74</accession>
    <name>F4FE74_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733598.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19205"/>
    <dbReference type="EnsemblBacteria" id="AEB44943">
        <property type="protein sequence ID" value="AEB44943"/>
        <property type="gene ID" value="VAB18032_19205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19205"/>
    <dbReference type="eggNOG" id="ENOG5030Z5E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1958413_0_0_11"/>
    <dbReference type="OMA" id="CHRVGAF"/>
    <dbReference type="OrthoDB" id="1690796at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="14226" checksum="98D05B5663F3345B" modified="2011-06-28" version="1">MSLTVSPDLLRAAESGPVTDEEFIACVRESLPYAWQTVSRVAAELATSDVEFSDNVIAPPGDAERGQLLRAMASDAIRAGLERHFGVKLAFQNCHRVAAFRTAAVDSDTYRRFVSARGQLLNQSPELRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FED9</accession>
    <name>F4FED9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, LysR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25535"/>
    <dbReference type="EnsemblBacteria" id="AEB46205">
        <property type="protein sequence ID" value="AEB46205"/>
        <property type="gene ID" value="VAB18032_25535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25535"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OMA" id="VLPVWAY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="307" mass="33705" checksum="D91D5363A4D3474B" modified="2011-06-28" version="1">MTGRELLEADALRCFAVFAEHRNFTAAAAALHISQPALHVKIRKLAAALDVDLYQRDGRRLTLTVAGERLAAYALDSRRRTDEFLRELHHESTPTLTIAAGRGALRWVVGEAIRQVGRQGRRVHVITADRDAALAALHAGQADLAVIAHDPPTRQVEAVQIAAYRQVLVLGERHPLAERRQVRLRDLDGLDLVVPPANRPHRRALDRALLDAGVRWQAAAEVDGWDLLVHLAGLGVGATVVNGCVGLPDGLRAVPIDGLPKIRYWATWRQPRAHLVRDFLSQFPPPDRTGRAGVSPPVEPDRAGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEE0</accession>
    <name>F4FEE0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25540"/>
    <dbReference type="EnsemblBacteria" id="AEB46206">
        <property type="protein sequence ID" value="AEB46206"/>
        <property type="gene ID" value="VAB18032_25540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25540"/>
    <dbReference type="eggNOG" id="ENOG5032U0I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131334_0_0_11"/>
    <dbReference type="OMA" id="SKCGPRV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="180" mass="19874" checksum="DBF6118B24ADAF5B" modified="2011-06-28" version="1">MNEDIPRLGIDIGRVIIDGSAHPSGDDTAFFSGDEATMLATPEVPGAVETIARLVPRFGGRVWLVSKCGPRVQARTLRWLAAHDFHRRSGVDPAQVRFCRARADKRQHCLDLALTHFVDDHPEVHAAIRGAVTHQYFFGPQRRPVPDYGHPTPTWADVERLVIDSLLTPACEAAPRRGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEH8</accession>
    <name>F4FEH8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736055.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01680"/>
    <dbReference type="EnsemblBacteria" id="AEB47420">
        <property type="protein sequence ID" value="AEB47420"/>
        <property type="gene ID" value="VAB18032_01680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01680"/>
    <dbReference type="eggNOG" id="ENOG50348J4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1933608_0_0_11"/>
    <dbReference type="OrthoDB" id="2060180at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="15670" checksum="2A77A1E3332720E5" modified="2011-06-28" version="1">MRINSRALDYFHPKPWDVIADQIGRYTAHHSPFMAEIVDSIRACGAAGRLAGFMSMHDLAVTPVPVPSQGPIEVVWVRPQPHSGAPEEREVLIEHYAPTGHDDRIWRPGTEAVALFWRFMIEKFGIEPNRADNRDGASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEJ6</accession>
    <name>F4FEJ6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 17" type="primary">hemA</name>
        <name evidence="17" type="ordered locus">VAB18032_01770</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736073.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01770"/>
    <dbReference type="EnsemblBacteria" id="AEB47438">
        <property type="protein sequence ID" value="AEB47438"/>
        <property type="gene ID" value="VAB18032_01770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01770"/>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_4_0_11"/>
    <dbReference type="OMA" id="FAFKCAA"/>
    <dbReference type="OrthoDB" id="1358620at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="173"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="322"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB47438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="442" mass="46157" checksum="F89E20AF8A633C99" modified="2011-06-28" version="1">MKLLVVGASYRTAPVATLERLAVAPESLTRILNRLVAQPYVSEAALVSTCNRVEVYAAVSGFHGGLGDICAVLAEQADCQPSALANNLYVHFDSAAVDHVFRVAAGLDSMVIGEAQILGQLRDAYHGATGADTTGRLLHELMQQALRVGKRAHSETGIDRAGQSVVTAALGLAARHLGDELAGRPALVVGAGAMGSLGVATLSRLGAGPLTVTNRSAERAVRLAESYGAAARPMAELADTLSTVDIVVAATAASEPVLTRDVVAGALAGRDPERGPLVLLDLAVPRDVGSGVAELPGVEVIDIDRMAELLADGPAAADAAAVERIVAGEVESFLTWLRGADVAPTVAALRGRAEDVVSAELRRLAQRRPDLSDDQRAEVARTVHRVVQRLLHQPTVRVRQLAAEPGGDQYAALLRELFDLEVPQTSQVDTVPDITPTSGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF39</accession>
    <name>F4FF39_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoglucanase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_13185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732419.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13185"/>
    <dbReference type="EnsemblBacteria" id="AEB43751">
        <property type="protein sequence ID" value="AEB43751"/>
        <property type="gene ID" value="VAB18032_13185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13185"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018488_0_0_11"/>
    <dbReference type="OMA" id="GTAPNGY"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307862" description="Endoglucanase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="6">
        <location>
            <begin position="356"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="459" mass="49064" checksum="940C7A58B77D4FAA" modified="2011-06-28" version="1">MRKLFAGVGAILLATVAAVFAFGPSAQAASGFTVSGGKLYDANGNEFIMRGVNHAHTWYTHQTSSFANIKALGANTVRVVLSSGDRWTRNSADDVRNVIELCKANRLICVLEVHDTTGYGEQSGAVSLDRAVDYWLSIASALNGQERFVIVNIGNEPYGNQNYSSWATDTSNAIRRLRNAGLTHTIMVDGPNWGQDWSFTMRDNAPTVFNADPARNIVFSIHMYGVFDTAAEISDYLGRFRSRQLPIVVGEFGHYHSDGDPDEDAILSYTQANGIGWLGWSWSGNGGGVEYLDMATNFNPNQLTSWGQRLFNGTNGIRQTSRQASVYDSLPPPTSPPPTTTPPPTSPPPTSPPPSSPPPSAGCTATYAISNQWQGGFQGDVRVTAGASAINGWTVRWTYANGQSVTQSWNATVSTSGSTVTARNVDYNGRLGAGASTSFGFIGGWAGTNSVPTVTCTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFP0</accession>
    <name>F4FFP0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nudix hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02165"/>
    <dbReference type="EnsemblBacteria" id="AEB47517">
        <property type="protein sequence ID" value="AEB47517"/>
        <property type="gene ID" value="VAB18032_02165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02165"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059078_0_0_11"/>
    <dbReference type="OMA" id="DTWFFVA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="PTHR12318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="263" mass="28381" checksum="09FD8E5EC9ACE7F1" modified="2011-06-28" version="1">MEHARRFWTSGDQPPVPRVAATVLLLRPAREGYEAYLIRRVAAMAFGGMYAFPGGGVDPSDSTTGVDWAGPTPASWGETLALAPAAAQAVVCAAAREVFEEAGVLLAGPDGSRVVGDVSDDSWERARVDLEQRRTGFAELLARRGLTLRSDLLLPWSRWVTPEFEPRRFDTYFFVALLPEGQRTRDVSGEADHTLWIRPADACARAGAGELSMLPPTLVTLGEVAACPDLDAVARAASARDAATPITPRLDLSDPDDPRFHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFU6</accession>
    <name>F4FFU6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_07010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07010"/>
    <dbReference type="EnsemblBacteria" id="AEB42526">
        <property type="protein sequence ID" value="AEB42526"/>
        <property type="gene ID" value="VAB18032_07010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07010"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_12_11"/>
    <dbReference type="OMA" id="LYQEFDG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1049"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2074"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1084"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="2162" mass="236660" checksum="4E885A57E4A11194" modified="2011-06-28" version="1">MDVAVDTDPTLTLDRMREDVAEALGCPPSLVGDDDDLLMLGLDSIALMRLASRWHSQGVPVTFSELIEWRTLAQWWALIEQRHAEARPAPLPPVEVDESAPFGLATMQHAYWIGRADGQPLGGVGAHFYNEFDGSGVDPQRLDAAVRAVLRRHGMLRAEFHADGTQQIRPESPWPGLTVHDLRDLPPQRCEEELAALRHRLSHRRLRVEEAETFDIQLSLLPGGATRVHVHVEMLVADAHSFRLILSDLAACYRDPDRQLPPVNLSYPAYLATVAARPDEARERAREYWRERLDTLPGPPQLPTAVDPATVAGHQVVRRYHWLTPQQQAELERRSAAAGVTLSMVFLAAFAEVLAAWSSSGRFVLNLPMYDRRPVHPEVGEVVGDFTNLILLELDTTGPAGFVDLVRRHQDRLRSDAANAAYSGVDVLRDLSRARSGQPVGAPVVFTSALSLGELFDAEVRNCFGRPGWTMSQTPQVWLDYQITEREDGLYLNWDVVDELFPDGFVDDMFAAYLGIVDWLLDPATDWSGRAPIALPERTRAARAAANDTAGPVDDRPLHHDVFTRAVREPDRPAVLSATGVLTYAELAGRAQALADELTTRGLAPGEAVAVTLPKGPDQIVAVLGVLRAGGVYVPIGVDQPQARRDLIRATADARFTVTTADAAPDATTHTVPTIAVPVRADAPTVDCEQDAYLLFTSGSTGTPKGVRVPHRAARNTLDDLVERFDIGPDDRVLAVSALDFDLSVFDMFALLGTGGAVVTVDEDTRRDPAAWLRLVHEHRVTIWQSVPALLDLLLTQAETAGDRSVPLRLAVLGGDRVGLDLAGRLARLAPDSRLYGLGGTTETAIHSTVQAAPVDPPPHWRSVPYGVPLRNQLMRVVDEHGRDRPDWVPGELWIGGRSVAAGYAGDPQRTADRFVEHDGQRWYRTGDLARYWPDGTVDFLGRTDFQVKIRGHRIELGEIEAALERDPDVSRAVAQVVDGSSLAAAVTVTRADADPQAIRQRAAEQLPPYMVPAVVVVLDAFPLSANGKIDRARLPELVATRPTVAGTPPRGEVEIAVAALWSELLGVPEVHREDNFFALGGDSLVATRLLARLRESGITGAELRHLFHARDLAEFAVRLRSRGAAAQRRELSADLVHRHDPFPPTDVQRAYWMGRTDDFALGGVGSHWYWEFDGGDVDLDRLNRAVNMLIARHEMLRAVFDDNGDQRILPEVPPFTITVHEGPEHLETLREQLSHRIPDPSRWPLIDIQAVRHPGGTRVAFSFDYIVLDALSIVIFFSELSTLYRDLDAELRPLGVSFRDYVLGATPPPEAIERAGAYWRGRLNDIAPAPALPLAVDPETLVAPRFVRRERSLTPQQWTAITHRAREHRLTPAAVLATAYAEVLSAYSGQDALTLNLTMFQRHDVHPDIGAILGDFTSLVLVGYRGAAQQPWRETAQLLQQDMWDGLEHNDVSALWVLRELARRRNSGTVSMPIVFTSALGVAADLVNMRFPFGELTWGISQTPQVWLDNQVMERDGGLTFNWDSVDELFPDGLLDAMFDAYHRLLCWLADGEWDRPLPDLLPPGQRAIRAAVNATEAPAPDHTLHGPFFDRAALDPGRLAVAHGETSISYGELATQALRIAGALLRSGVEPGDAVAVTVPRGPDQVAAVLGVLAAGASYVPVSVDQPAARRDRIYTKAQVTAVVGRPGAHHLPTVAADVDTPPLRGPVTVAADALAYTIFTSGSTGEPKGVEITHRAAVNTVTDINSRYDVGPDDRVLAVSALDFDLSVYDIFGLLTAGGALVVLAEEERREARRWAQLAHRWGVTVWNSVPALLDMLLVAAGDHPPAGLRLALLSGDWIGLDLPGRLAQVAPHARFVALGGATEAAIWSNACEVEAVPEHWRSIPYGRPLRNQRYRVTDPRGRDCPDWVPGELRIGGAGVALGYRNAPDLTARQFSVDDEGCRWYRTGDLGRYWPDGTLEFLGRVDFQVKVRGHRIELGEIEAAAEAHPQVGRAVAMVVGQAPSQHIGLAVVPATGEPDLAGWLAERLPAYMVPEYVVTVDQLPLTANGKVDRQRLGTLLRADPLDDAAEPPKGPTEESLAVLWSQLLDQPVADRRHSFFALGGDSLLATRLLEALRQRFGVDMTLRQLFAVPVLAQLAAAVDEQLRASADDDVEEGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFZ4</accession>
    <name>F4FFZ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_07250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731247.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07250"/>
    <dbReference type="EnsemblBacteria" id="AEB42574">
        <property type="protein sequence ID" value="AEB42574"/>
        <property type="gene ID" value="VAB18032_07250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07250"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_4_0_11"/>
    <dbReference type="OMA" id="VIAVIQY"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="33674" checksum="8F033C51EB0C1F45" modified="2011-06-28" version="1">MTQTETAVKASSRPAWRRVNWRDYVVYIGFVVVFLFFAITQGSNGFLTTSNLTNIIIQTAPITVMAIGLVFVLAAGEIDLSIGSVVALSALVGAVTLRETDNMLLGAAAGLAAGAAVGLVNGLFVTLVRLPSFLVTLATMGAVAGLAREVTGLQSVPVSNEAFLSLFGQGEVFGIPNLVLWSVAATVIGYLVLRQTRYGAHTLAIGDNVAAARVSGIKVIRVKIMVLMGSAMCAAIAGLLYAGRLQGARYTLGEADLMSVIAAVIVGGTSLFGGKGSIVGALLGSLLMGMLNNGLILAGLSVSQQMMARGAIILVAVSLSLRERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG36</accession>
    <name>F4FG36_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">20S proteasome subunit A/B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732447.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13340"/>
    <dbReference type="EnsemblBacteria" id="AEB43780">
        <property type="protein sequence ID" value="AEB43780"/>
        <property type="gene ID" value="VAB18032_13340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13340"/>
    <dbReference type="eggNOG" id="COG0638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198705_0_0_11"/>
    <dbReference type="OMA" id="PHGLIGH"/>
    <dbReference type="OrthoDB" id="1141739at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="24777" checksum="1D7F169F496B9945" modified="2011-06-28" version="1">MTVVLAVVCSDGVVIGADSQITESDRGLSFPAQKLHPLGTCAAWGGSGARGVLNDLRPLLEESATAILEAPEIGDELQERVLPVFKKHYQNYIPDVPGEDSGGGVSAYLLAAGYSQGGPWIVEINPNGLIGRYEDVGFHAIGSGAPMAQQAGALLSHFRMTTRTVEYGVVGVARVLEALERTSPSVGRPFSIACIREEGAHHLDEKEIAKALKDAQRWRDLEQEALDRLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG46</accession>
    <name>F4FG46_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732457.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13390"/>
    <dbReference type="EnsemblBacteria" id="AEB43790">
        <property type="protein sequence ID" value="AEB43790"/>
        <property type="gene ID" value="VAB18032_13390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13390"/>
    <dbReference type="HOGENOM" id="CLU_1371711_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="199" mass="22270" checksum="F36B02AC2EA0E523" modified="2011-06-28" version="1">MTYPDPGGANNEFYTDPPPPRTARELVTQLGIEEARAFLPEAQQQAFDTANPWTDIVRADERLAQRQEELAAFDGDVQRHITEQGYTVEQARVVYAQTADVRQPLQDAVNRAAQRASNAYNTYEANLVNFIESRRLTQIVAYQSGRYSMQDPRVAAAASLSSSGNNRHDRRDRRDRDGRGGGRAPLGQISGNQRHTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGU9</accession>
    <name>F4FGU9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chalcone and stilbene synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_02625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736241.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02625"/>
    <dbReference type="EnsemblBacteria" id="AEB47609">
        <property type="protein sequence ID" value="AEB47609"/>
        <property type="gene ID" value="VAB18032_02625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02625"/>
    <dbReference type="eggNOG" id="COG3424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034992_0_1_11"/>
    <dbReference type="OMA" id="PIWGLGC"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="4">
        <location>
            <begin position="220"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="37039" checksum="E26E677B8BB0A600" modified="2011-06-28" version="1">MSVPVIAGLGTASPPSADQDELWERFFSRHYSGSTRALAERIFANSGVDRRQAAVNPLIEDVSDWPTERRMRRYQVEALPLGKEAVGRALTSAGLAAGDIGLFVVCSCTGYATPGLDILLARDLGMAPSTQRMFVGHMGCYAALPGLGAASDFVTARGRPALLLCAELTSLHLQPSSARVDTQQIISHALFSDAAVAAVVVPGGRGYAVRSVTSVTDSSTADHMTWDVTDTGFRMGLSPKVPQVLSAHVRGLVDELLTSHGSQLSDVDGWAVHPGGPRILNVVERELALAPAALAASRQTLAEHGNCSSPTVLLILDRLLRYAPSPRRVVMLAFGPGLTLYAALLERHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGX0</accession>
    <name>F4FGX0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736262.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02730"/>
    <dbReference type="EnsemblBacteria" id="AEB47630">
        <property type="protein sequence ID" value="AEB47630"/>
        <property type="gene ID" value="VAB18032_02730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02730"/>
    <dbReference type="eggNOG" id="COG5495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055635_0_0_11"/>
    <dbReference type="OMA" id="GEPEWIA"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="163"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="318" mass="32028" checksum="BAC8A00103A3D9D2" modified="2011-06-28" version="1">MSAPLRTRPAARRRPATVPFATIPAVLTVGIVGAGRVGATLGAALAAVGHRVVATTGSSGASQARVALLLPTVSRRAAAEVARAATDLLLIAVPDDALAGVVAGLAAEGALRPGQVVAHTSGAHGLAVLAPAVAVGVRPLALHPAMTFTGTPDDLSRLSGISYGVTAPAELRPLAARLVADLGGVPEWIGEADRPLYHAALAHGANHLVTLVNEAADRLRDAGVAQPEKVLAPLLRAALENALRLGDDALTGPVARGDAGTVARHLTQLTATAPESVPAYLALARRTADRAMAAGRLRPVDAEPLLGVLDRDQSGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGY1</accession>
    <name>F4FGY1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_07365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731268.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07365"/>
    <dbReference type="EnsemblBacteria" id="AEB42595">
        <property type="protein sequence ID" value="AEB42595"/>
        <property type="gene ID" value="VAB18032_07365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07365"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="SEYAMSI"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="29"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="265" mass="28509" checksum="E43465C4D0E1DAFF" modified="2011-06-28" version="1">MRIVHRVEPDQPPSPRSGRDPDHAHGNGMVASGLRHAYGPLTVLDLDTFTIAPGDRHAVIGPNGAGKSTLLGVLAGTIRAQTGQLTYNGHTVTRHGAEWRARAGIGRTFQHPTLWPDLTCLDCVRIGGWHHRRNPDRTPMEVLHLVGLADHAHQRAGSLSHGHRRMLDLAVAIAGQPRILLLDEPAAGLTDTETGHLIDTIHRMPSWIAVVLVEHHMDVVAAVADWITVLHQGRRHTDGPADTVRADPGVAALYLGTGGGHAAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH12</accession>
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        </submittedName>
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        <name evidence="2" type="ordered locus">VAB18032_07530</name>
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    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07530"/>
    <dbReference type="EnsemblBacteria" id="AEB42626">
        <property type="protein sequence ID" value="AEB42626"/>
        <property type="gene ID" value="VAB18032_07530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07530"/>
    <dbReference type="HOGENOM" id="CLU_2774820_0_0_11"/>
    <dbReference type="OMA" id="CDHRRPH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7623" checksum="A666240C40189E72" modified="2011-06-28" version="1">MSHSAAHRVIDTVGPLLALAPVRRRRVDQITIVDGTLIPTCDHRRPHRARTTATARTCRSPSTLTPAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH19</accession>
    <name>F4FH19_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Lsr2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731306.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07565"/>
    <dbReference type="EnsemblBacteria" id="AEB42633">
        <property type="protein sequence ID" value="AEB42633"/>
        <property type="gene ID" value="VAB18032_07565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07565"/>
    <dbReference type="HOGENOM" id="CLU_139818_0_0_11"/>
    <dbReference type="OMA" id="QEIRTWW"/>
    <dbReference type="OrthoDB" id="370464at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="13007" checksum="B928663ACCC3819D" modified="2011-06-28" version="1">MATRTTAVLVDDLDGSTDDVGTYQFAFNGVTYEIDLSAGNFDRMAAAFGPFITAGRRLPKQPKTARRRQSGSAAGRTHTQEIRTWWWTTNWQERNLPQPRTGGIIPAAVRDAYHAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH26</accession>
    <name>F4FH26_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07600"/>
    <dbReference type="EnsemblBacteria" id="AEB42640">
        <property type="protein sequence ID" value="AEB42640"/>
        <property type="gene ID" value="VAB18032_07600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07600"/>
    <dbReference type="eggNOG" id="ENOG502ZFHV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701729_0_0_11"/>
    <dbReference type="OMA" id="AVDPYAC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025463">
        <property type="entry name" value="DUF4314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14192">
        <property type="entry name" value="DUF4314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4314" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="361" mass="39389" checksum="5B41A7A9623AAF30" modified="2011-06-28" version="1">MIYEPGQRVALVHTSDPYTLLRPGDTGTVRRHDQQHHTVDVTWDSGSTLSMCLDDGDRIEPLTTTASTGDPVDDAAGWAATLRRIRAAGTEAGRTAADWWAQNTIGARASGDTRLAARRILTGIDAGDPAVLDTLPQPTAAGDAVDTSGWQLFADATGDVSGWFGLRIPQRDEAMTVYRDAFDTAAVDRVTELCHLAASPTGRDVSHLHPDRIRIGDVGVFSGDWARTTGPDGDDRITVGFVGTLIDRWNGWAVFSCTREVAEAIVADHQRHRDQYRHRLRDEGVPEDDLDRRVDAALADLSFDGDVIVADQRATSDDPEAIDHITPDGDGRYVVMGRSWCWEAVDPYACDRIFGDLPDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHB0</accession>
    <name>F4FHB0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732555.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13880"/>
    <dbReference type="EnsemblBacteria" id="AEB43888">
        <property type="protein sequence ID" value="AEB43888"/>
        <property type="gene ID" value="VAB18032_13880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13880"/>
    <dbReference type="eggNOG" id="ENOG5032A6K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244590_0_0_11"/>
    <dbReference type="OMA" id="AFEVACM"/>
    <dbReference type="OrthoDB" id="1808474at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="224" mass="24770" checksum="C230ADD00E2DA17A" modified="2011-06-28" version="1">MVAEPILLDRPRSPSTLPPLDWTTLADAFEAACLLRCMPPPARPGPRHAGQRPSLPTAIEFNREEAARRTRQLLDRLGIPVQHELAVGGLRRRYELHRLHVARDARSDYTALMENGWHRGRRELLGGPAPGASTARRQWRTRLASAAWRAALLAGGRHVRRHILGVRITDRELAAVLVRGAALLDVPALLRAGTGCYLVSVAHGPDRDRILHHAGEEVAHRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHC3</accession>
    <name>F4FHC3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgC</name>
        <name evidence="12" type="ordered locus">VAB18032_13945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732568.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13945"/>
    <dbReference type="EnsemblBacteria" id="AEB43901">
        <property type="protein sequence ID" value="AEB43901"/>
        <property type="gene ID" value="VAB18032_13945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13945"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_1_11"/>
    <dbReference type="OMA" id="YRMDFSQ"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="410" mass="45672" checksum="BE61799CE6A40807" modified="2011-06-28" version="1">MAEKVLAIVLAGGEGKRLMPLTTDRAKPAVPFGGMYRMVDFVLSNLANAGYLKIVVLTQYKSHSLDRHITKTWRMSTLLGNYVTPVPAQQRRGPWWFSGSADAIYQSFNLIYDEQPDYVIVFGADHIYRMDPRQMVEEHIASGAAVTVAGIRQPLSTADQFGVIEVAEDGRRIRAFREKPTDAVGLPDAPDEIYASMGNYVFTTRALIDAVERDAEDRSSKHDMGGSIIPMLVERGEANVYDFRDNEVPGSTDRDRGYWRDVGTLDSFYDAHMDLINVHPVFNLYNFDWPIYTEQPPYPPAKFVHQWGERVGRAVASMVSPGAVISGSLVENSIVSPKVKVHSWAHVDGSVLMEGVEIGRHAVVRRAILDKNVHVPEGAEIGVDLERDRQRYTVSDNGIVVIGKGQKVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHH2</accession>
    <name>F4FHH2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733799.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20220"/>
    <dbReference type="EnsemblBacteria" id="AEB45144">
        <property type="protein sequence ID" value="AEB45144"/>
        <property type="gene ID" value="VAB18032_20220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20220"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039848_5_0_11"/>
    <dbReference type="OMA" id="PGDIGVH"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlcB" evidence="5">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="21796" checksum="F85FD07656B1E60F" modified="2011-06-28" version="1">MTDHYQRQVPGFGTVTFRPVDPDADAEVIHGWTSQERARFWGMRDADRDRVAEIYRYVDSLPTHHAWLTLRDGQPVALFQTYQPEHDPVGECYPVRPGDHGGHLLIGTPVRPEPGFTGTLLAEFIAFVFTDPTRLRLVMEPDARNDKAIARLKRAGFVEGPLIDLPHKRARLMFLDRAPDPADGPPAAVSAHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHL9</accession>
    <name>F4FHL9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate synthase (Ferredoxin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">VAB18032_26556</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26556"/>
    <dbReference type="MEROPS" id="C44.003"/>
    <dbReference type="EnsemblBacteria" id="AEB46388">
        <property type="protein sequence ID" value="AEB46388"/>
        <property type="gene ID" value="VAB18032_26556"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26556"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_11"/>
    <dbReference type="OMA" id="TVFRLQH"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="34"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1542"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1542"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB46388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1603" mass="172333" checksum="7C896AE68B6F0327" modified="2011-06-28" version="1">MAFAYPHRPQPAPQHPQVTSPAGLYDAAHEHDACGVAFVADLHGRRSHTVVANGLGALCRLDHRGARGAEPNTGDGAGIMIQVPDAFLRAVVDFPLPPAGEYATGLVFLPDDDAGEARARQVVEKYALVEGAELLGWRDVPVDPSDLGATALAAMPRVRQLFLAARRLTDTPAGPAGSPLRGLELERVAFCVRKQAERESAERGVPAYFPSLSGRTMVYKGMLTPDQLPAYYPDLTDERVDSAIALVHSRFSTNTFPSWPLAHPYRFIAHNGEINTIRGNRNWMQAREALLRTPELSGNIRRVFPICTPAASDSANFDEVLELLHLAGRSLPHAVLMMIPEAWENDPDMAADKRAFYRFHASLMEPWDGPASVAFTDGEIVGAVLDRNGLRPGRWWQTADGLVVLGSEAGVLDLDPATVVAKGRLQPGKMFLVDTTAGRIVHDDEIKTELAAAQPYADWLHAGLIELDDLPAREHQVYTHDSVRRRQLTFGYTEEELKILLAPMARTGAEPIGSMGTDTPIAPLSTRPRLLYDYFHQLFAQVTNPPLDAIREELVTSLAMTIGPEGNLLDPGPASCRQIVLPYPVIDNDELAKILSIDEDGDLPGFKAVRVSGLYRIRDGGAGIKARLTEICRHVSEAIEDGVRILVLSDRDSNADLAPIPSLLLTAAVHQHLVREQTRTQVALIVESGDCREVHHAAVLIGYGAAAVNPYLAFESVEDMISTGALAGVEPRAAIRNYVKALGKGVLKIMSKMGISTVSSYCGAQVFEAVGLDTRLIERYFRGTPSTISGVGLDGIHAEVAARHALAWPAPGLTASDRLPVGGEYQWRREGELHLFNPETVFLLQHATRSRQYDVFRSYTAKVDELAAKAGSLRGLFRLRTGELPPVPIEEVEPASEIVKRFATGAMSYGSISAESHETLAIAMNRLGGKSNTGEGGEDVDRLHDPLRRSSVKQIASGRFGVTSEYLVNADDLQIKMAQGAKPGEGGQLPGNKVWPWIARTRHATPGVGLISPPPHHDIYSIEDLAQLVHDLKCVNPAARVHVKLVSEVGVGTVAAGVAKLKADVILISGHDGGTGASPLNSLKHAGTPWELGLAEAQQTLLLNKLRDRVTVQVDGQLKTGRDVIVAALLGAEEFGFATAPLIVSGCIMMRVCHLDTCPVGIATQNPVLRERFTGKPEFVENFFLFLAEEIRGYLAELGLRSIDEAIGRTELLDVAPAIEHWKAGGLDLHRVLHLPQLPDQTARRGVRAQDHGLELALDNQLIALAEPALHGDGAPVRAEVTIRNEHRSVGAMLGGEVTRRYGGAGLPTDTIEFTLRGTAGQSFGAFLPRGVTLRLYGDANDYVGKGLSGGRLIVRPAPTSPFVAPDAAPGGRAEDQIIAGNTILYGATGGEVFLRGRVGERFAVRNSGAAAVVEGVGDHGCEYMTGGTVVVLGATGRNFAAGMSGGTAFVWNLDRRRVNTELVDLSAPSETERARLHELVQRHFAETDSAVAEQLLKRWPEAVEEFTAVVPRDYRRVMEIMQAAEAAGQDVDDAVMSALAAPAATQSQPAPTEASQPAPTEASQPAPTEASQPAPTEASQPTPGEVSLAPANRVVAQEVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHQ1</accession>
    <name>F4FHQ1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735071.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26736"/>
    <dbReference type="EnsemblBacteria" id="AEB46420">
        <property type="protein sequence ID" value="AEB46420"/>
        <property type="gene ID" value="VAB18032_26736"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26736"/>
    <dbReference type="eggNOG" id="ENOG503497V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059380_0_0_11"/>
    <dbReference type="OMA" id="RTGCACV"/>
    <dbReference type="OrthoDB" id="1941506at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="345" mass="36258" checksum="A9AE17132791C839" modified="2011-06-28" version="1">MRAGDLLRQLDQRLLPRLATVLTRLDQKTARASLLSWVAVLSCAAVLFTAVFATGGPPLPDRTVGEVTRVGIADGDSIPSYERTAAADLAGLARSASLAEGTYALVSLSEYVTPQSLAAVVGDVGVSFVFGRVPLPDRQTEIVRIPAQRLPDDVTAGMADLAARKAREAADYRSRAAALVGGDPQERELRQLYVSGARLAEREAAAYRTGCACVYAVVVRAEPAVLRGVAARPGVRVVDPAPEVRRLERTVFTPPLPEQRDVARPPIDRDLLPSPSPSAKSPVPSPEAPENRVPQTPEVTDSSPAPVPSRPAPTSAAPSAAPTSTDSLQDGDVDAQLEGGAELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHU6</accession>
    <name>F4FHU6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736271.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02775"/>
    <dbReference type="EnsemblBacteria" id="AEB47639">
        <property type="protein sequence ID" value="AEB47639"/>
        <property type="gene ID" value="VAB18032_02775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02775"/>
    <dbReference type="eggNOG" id="ENOG503334W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183126_0_0_11"/>
    <dbReference type="OMA" id="WHELTGH"/>
    <dbReference type="OrthoDB" id="1831235at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="11124" checksum="6AC92E3CC63E51B7" modified="2011-06-28" version="1">MTDTSSSSGGRSFEALDALSTEELREQAFAVARERRDVKFFWSVLRHLPNADEAAALDGAPNSVGPTVDEAVALWREMTGHGYEESAPLLRAAFIDYLLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHU7</accession>
    <name>F4FHU7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02780"/>
    <dbReference type="EnsemblBacteria" id="AEB47640">
        <property type="protein sequence ID" value="AEB47640"/>
        <property type="gene ID" value="VAB18032_02780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02780"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038566_0_0_11"/>
    <dbReference type="OMA" id="HVPGWAA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="407" mass="41422" checksum="C5B5D71C2BB73784" modified="2011-06-28" version="1">MMAYDEPGRSGQAESTPVGSTVGTDTVADDRQNGEPGGDRFGVYVLWETLLLLGFAALVYLLWLENPTALRGSGLRALIVDVVALGLLALAAGLTLRTAAVNLAIGPVAVAAGLNFAEQSDRGLLIAVGTPAAVAAVGGLVLGLVVVLLHVPGWAASLGAAAGVVVYIEQRAAPVLVQGDYDPRDIAGQLFVGFAALTVIGGLFGAIGPIRRLVGRFRPVADPARRRGVAAAVVTTGGYVCSTVLAMLAGALLASKDDAVIPGDGLDWTVLAVGAVLLAGTSAFGLRGGVFGTLLTVGAVGLFLAYAQARGWTVSRWVVGGAALAAGLAVTRLVERYGRPVVGPPRPVSPPAAGEPTGGAGGWAMSQPEPVGDWPPVLPAQSTGDPTDPWGPRRWETNSPIWQADDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHY6</accession>
    <name>F4FHY6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_02975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736311.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02975"/>
    <dbReference type="EnsemblBacteria" id="AEB47679">
        <property type="protein sequence ID" value="AEB47679"/>
        <property type="gene ID" value="VAB18032_02975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02975"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_11"/>
    <dbReference type="OMA" id="MMQKAAT"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="388" mass="41212" checksum="2F17A0A787C49D39" modified="2011-06-28" version="1">MTNFDLSPEQDQLREAVRALGRRYGHRYFVEKAKAGEHTTELWHEAGRLGYLGVNIPTEYGGGGGGITELAIVCEELAAAGCPLLLLVVSPAIAATVIHRHGTEEQRKRHLPGLADGSQKIVFAITEPDAGSNFHRLATVARRDGDDWLLSGRKCYISGVDEAQHVLVVARTEDAATGKLKPALFLVPTDAPGMTRAKLDMEIVSPENQFLLYLDDVRLPADALVGESLDAGLPALFAGLNPERITVAAMGAGTGRYAIERATEYTATRAVWGGRTIGTHQGVSHPLAHAAVQVELARLMIQKAAALYDAGRDLEAGVAGNMAKYASSEAAALAVDTAVQALGGAGMTTEYGVATLLGAVRASRIAPVSREMILNFVAQHILGQDKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI46</accession>
    <name>F4FI46_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30234"/>
    <dbReference type="EnsemblBacteria" id="AEB48010">
        <property type="protein sequence ID" value="AEB48010"/>
        <property type="gene ID" value="VAB18032_30234"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30234"/>
    <dbReference type="HOGENOM" id="CLU_3391930_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="32" mass="3531" checksum="52E6C91414BAA9EC" modified="2011-06-28" version="1">MVEISFRLRLPQAVVIKILVIVLVVSLGPWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1J0</accession>
    <name>F4F1J0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733873.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20595"/>
    <dbReference type="EnsemblBacteria" id="AEB45219">
        <property type="protein sequence ID" value="AEB45219"/>
        <property type="gene ID" value="VAB18032_20595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20595"/>
    <dbReference type="eggNOG" id="ENOG5033857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1199087_0_0_11"/>
    <dbReference type="OMA" id="AYAEGEW"/>
    <dbReference type="OrthoDB" id="1808650at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="232" mass="24625" checksum="579E095C09AA5F76" modified="2011-06-28" version="1">MGAADQGLSDDEVRGIREALAAGRKPKVMFTAAAGQIAGQLGQVVELTDPSVSDEFVVVRFGRDELPFSPADVAMAPRGAGRRPAESKVEAAPAEPVAAEPEFVLDQVPQPRREEPKVREESKVEAAEAKPARRAVKAAKPKGPAGLTVTLAYAEGEWTVAAQQGAKALAKPYVVKPAEALRMVALVDVPGVHEAVEQILAAERAEAERQAEKLRAELAEIEARLAELREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1L7</accession>
    <name>F4F1L7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein merr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733900.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45246">
        <property type="protein sequence ID" value="AEB45246"/>
        <property type="gene ID" value="VAB18032_20730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20730"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_7_4_11"/>
    <dbReference type="OMA" id="DYPAFTM"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="105" mass="11924" checksum="B9FC6235452D6DB7" modified="2011-06-28" version="1">MAQPDDVLDDDNYPAYTMGRAAEIVGASQDFLRRLDEAKLIIPFRSAGGHRRYSRYQLRLAARAREMVDHGTALEAACRIIILEDQLEEALQQNRNHQRRQSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1S9</accession>
    <name>F4F1S9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27156"/>
    <dbReference type="EnsemblBacteria" id="AEB46504">
        <property type="protein sequence ID" value="AEB46504"/>
        <property type="gene ID" value="VAB18032_27156"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27156"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137630_0_0_11"/>
    <dbReference type="OMA" id="GARICVN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="26901" checksum="59A41D4558EDE935" modified="2011-06-28" version="1">MTFTGGDPSLRRDLDVLVGHAQAQGMAVEVLTNAQHQPPTVRAALLRADLVGLSLDGGDAATHDGFRQRPGNYVRVLKLMDFLDEAGQPYVVRTVVSRANMSGILLLAPMLTSRRALVRWSLQQFSAVESGYQNRARYELPTEEFLCVCEDARRRLGSAAEKLSVLTDDGKVGLYLLVDPGGNVLARIEDPPAGRLPAIGNLLNDHLADLASRIVLDAPRHAARYEDWMHHDGPGHSQWTHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1W8</accession>
    <name>F4F1W8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclic nucleotide phosphodiesterase class-III family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736347.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03155"/>
    <dbReference type="EnsemblBacteria" id="AEB47715">
        <property type="protein sequence ID" value="AEB47715"/>
        <property type="gene ID" value="VAB18032_03155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03155"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070320_2_1_11"/>
    <dbReference type="OMA" id="TGIGHMD"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07402">
        <property type="entry name" value="MPP_GpdQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026575">
        <property type="entry name" value="GpdQ/CpdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="2"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="27561" checksum="5E4EF54EAC773D9E" modified="2011-06-28" version="1">MLIAHLSDPHLTTGVLGAEPAAGLHHALGRVLALNPRPDCVVITGDLADHGRPDEYAALREVIGRFPLPLYLTTGNHDDRESLLDAFGGTPWLGGSFSAYYQVEQPGLTLVVLDSLVPGSNGGRLGAEQLTWLDGVLAARPDVPAVLCLHHPPVEVGIPAADEIRLADGDAFAEVLLRHPQVVRVAAGHLHRPVTTMFAGTVLTVAPSTWRQATLTMSDDEQIGWVTEPTALLLHQVSDRGCVTHTVQVSHTAGMTCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2D0</accession>
    <name>F4F2D0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14450"/>
    <dbReference type="EnsemblBacteria" id="AEB44002">
        <property type="protein sequence ID" value="AEB44002"/>
        <property type="gene ID" value="VAB18032_14450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14450"/>
    <dbReference type="HOGENOM" id="CLU_187779_0_0_11"/>
    <dbReference type="OMA" id="GWFRLTL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="91" mass="9515" checksum="F1D457494DF2208B" modified="2011-06-28" version="1">MVSDTPADSVAPRRPDDQEIAMSGWFRLTLGLLGVVLGAACTVQGLGYVEGSVMAGQRIWAVIGPVLMLAGLVLLWLGARARNRRGSGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2H6</accession>
    <name>F4F2H6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, emrb/qaca subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_14680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14680"/>
    <dbReference type="EnsemblBacteria" id="AEB44048">
        <property type="protein sequence ID" value="AEB44048"/>
        <property type="gene ID" value="VAB18032_14680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14680"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OMA" id="WAINSYT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="503" mass="52303" checksum="351ED4E88CD6B300" modified="2011-06-28" version="1">MLVISLLVVVLDNTILNVALRRLADPVHGLGASHGELEWFINSYTLVFAGLLFTFGVLGDRAGRRRMMLIGLVLFGLASLLSAYAQNPAQLIAARALMGAGGAAIMPATLSIISNVFDPRERGRAIGIWAGAVGLAMAIGPILGGLLLEHFWWGSVFLINVPVVALGVVLVALLVPESRDPNPGRIDVLGVALSVVGLVTLTYGIIDGGEHGFGRPLVWAAIVGGLAVLAWFIAHERRSSHPSLDVRLFREPRFAVPVALIGLVFFAAMGVMFFSSFYLQLVRGYSPLQTGLIFLPFAVAQLFFAPRSAAMVRRYGPRAVAVVGLVLSAVALGAFALIDAVTPIWVVLVFFFIQGAGMANIMPPATESIMSALPREKAGVGSAVSNTIRQVAAALGVAVLGSVLAAGYRNGIDPALTELPPQAREAAGESISGAYAAAGQLGPTAPQLITAANDAFISAMHWSAALAALVTAAGILVALRWMPTRSGTGAPAAVGEPELAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2L2</accession>
    <name>F4F2L2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenocysteine-specific translation elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733931.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20885"/>
    <dbReference type="EnsemblBacteria" id="AEB45277">
        <property type="protein sequence ID" value="AEB45277"/>
        <property type="gene ID" value="VAB18032_20885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20885"/>
    <dbReference type="eggNOG" id="COG3276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023030_1_1_11"/>
    <dbReference type="OMA" id="WVDRAFT"/>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004535">
        <property type="entry name" value="Transl_elong_SelB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00475">
        <property type="entry name" value="selB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="585" mass="61402" checksum="C88A0F11F370BE7E" modified="2011-06-28" version="1">MLVVATAGHVDHGKSTLVRALTGMEPDRWAEERRRGMTIDLGFAWTTLPSGATVAFVDVPGHERFVPNMLAGVGPVPAAMVVVAADEGWMPQSAEHLAALDALGVAYGLLVVTRADLADPGPVLEHAGAHLAATSLRDVEAVAVSAVTGAGLPQLRAALDRLAARLPTASTDGPVRLWVDRSFTMRGSGTVVTGTLGAGELRVGTELVVAGSGEPVRVRGLHRLGQPCEQVGPVARVAVNLRGVARDRIARGDALLTPDGFASTDLVDVRLAGDPAADLPATLTLHVGSAAVPVRVRPLGVDTLRLRLARPLPLLIGDRALLRDPGRHHVAGGVTVLDVAPPPLRRRGAAAARAAVLAGMDGRPDLAGELRRRGLVRAADLRRAGVPVTGAPVCGGWLADPEHWRQLGRRLADAVADHARRHPLEPGAPVEVLRQRLDLPDRALVEALVRAPLRLAAGRVGTADADTLPEPVARALALLREELTTRPFRAPEADRLAAVGLGTREIGAAVRAGVLLRLTGNVLLPSGAPQQAVRVLATLPQPFTLSAARQALDTTRRVAVPLLELLDRQGATRRLPDDTRMVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2N1</accession>
    <name>F4F2N1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733950.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20980"/>
    <dbReference type="EnsemblBacteria" id="AEB45296">
        <property type="protein sequence ID" value="AEB45296"/>
        <property type="gene ID" value="VAB18032_20980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20980"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_11"/>
    <dbReference type="OMA" id="HCIHHDA"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="284" mass="30729" checksum="DEEF8B67AE8357CF" modified="2011-06-28" version="1">MSTPARFRHLTVDGRRVHHRVDGAGPPVLLLHGIGRTLRDFTEQHDLLADRYRVHSVDLPGHGGSLPMTEPYTLPALARFVGAYLDAAGVDEPVHLVGNSLGGAVAMGYAVTRPTRVASLTLVASAGFGREVTLALRLITLPGLGRLLLRPSRHTAGRAERALFHDPTLASPERIGHTLAVARRPYAARVVLETARGLGTVRGIRQPWRDELLGRLAGLGLPTLVVWGDDDRILPPAHLAAARTLLPHARTQVFAGCGHLPQVERAEEFSELVRDFWATAPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2P9</accession>
    <name>F4F2P9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733968.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21070"/>
    <dbReference type="EnsemblBacteria" id="AEB45314">
        <property type="protein sequence ID" value="AEB45314"/>
        <property type="gene ID" value="VAB18032_21070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21070"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_0_0_11"/>
    <dbReference type="OMA" id="EFWQLYV"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="430" mass="44056" checksum="985348DD44F38C32" modified="2011-06-28" version="1">MILTIAGGRRLATTLYAYAFLTDLVLLYPVYALLFADSGLSVGQISSLFVIWSVAGIALDVPSGAWADATSRRLLLCLAPLCTAAGFALWTFVPSYPAFALGFVLWGAGGALASGALEALVFDELDHLGLAQRYARTIGRARTAGTVGVLASIVLAGPVLGYGGYPAVGLASVAACLLAAAVATRFPEHRATATDTLIVAAPAAPAAPVAPTQHRDPADPADEPGWWQGLRGGLAEARRDRRVRAGVLLVAVVTATWGALEEYTPLLARDTGVALTTVPLLLLLLAVGQVLGGLLAPAGERLRVRGYALLLAGSAAALASGALLRHPAGFVLLAGAFCGFQLASVLADARLQARISGTRRATITSLAGMATELITIAVYIGFGVVATASGNGVAFALAALPYALIALLMLRGGRPTSRRSRPEALASSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F343</accession>
    <name>F4F343_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-xylanase</fullName>
            <ecNumber evidence="5">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_03700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03700"/>
    <dbReference type="EnsemblBacteria" id="AEB47822">
        <property type="protein sequence ID" value="AEB47822"/>
        <property type="gene ID" value="VAB18032_03700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03700"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016688_0_0_11"/>
    <dbReference type="OMA" id="STQANAY"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="PTHR40631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH10" evidence="8">
        <location>
            <begin position="7"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="7">
        <location>
            <begin position="347"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="784" mass="85236" checksum="127D19AD181DBA3C" modified="2011-06-28" version="1">MLPTLAHAAESTLGAAANQSGRYFGAAVAANKLNDGAYTTILNREFNSVTPENEMKIDATEPQQNNFTFGNADRIVNHALSRGWKVRGHTLAWHSQQPAWMERMEGQALRSAMLNHVTRVATYYRGKIDSWDVVNEAFEDGNSGARRNSNLQRTGGDWIEAAFRAARAADPGAKLCYNDYNTDNWTWAKTQAVYNMVRDFKQRGVPIDCVGFQSHFNAQSAYNSNYRTTLSSFAALGVDVQITELDIEGSGSTQANTYRAVVNDCLAVPRCNGITVWGIRDSDSWRSYGTPLLFDNNGNKKQAYTATLDALNSATPGPTPTPTTPGPTPTPTPPPSGSANEIVGNQSGRCIDVPNASQSNGTRVQLYDCNKQTNQAWTYTANRQLQVYGNMCLDAAGTGNGAAVQIYSCHTGTNQQWNVNSNGTISGVQSGRCLDVWSTSNGAQVQLYDCHTGANQQFRLVSLGGSNPPPTTPPPTTPPPGTSCDLPSSYRWSSTGALAQPRSGWVSLKDFTHAPYNGQHLVYATTHDTGTTWGSMNFGLFSNWNQMGSASQNQMPFAAVAPSLFYFAPRNIWVLAYQWGGPAFSYRTSTDPTNVNSWSSAQTLFTGSISNSSTGPIDQALIGDDQNMYLFFAGDNGRIYRASMPIGNFPGSFGSNYTTIMTDTTNNLFEGVQVYKLQGQQRYLMIVEAIGSQGRYFRSFTATSLGGTWTPQATSESNPFAGKANSNATWTNDISHGELIRSNADQTMTVDPCNLQLLYQGRSPNSGGDYGLLPYRPGVLTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F370</accession>
    <name>F4F370_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736481.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03835"/>
    <dbReference type="EnsemblBacteria" id="AEB47849">
        <property type="protein sequence ID" value="AEB47849"/>
        <property type="gene ID" value="VAB18032_03835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03835"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_13_0_11"/>
    <dbReference type="OMA" id="RIAPACI"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="66" mass="7702" checksum="6BB3DB63E9D223C6" modified="2011-06-28" version="1">MTARRTPTGNLLTLAEVLDELRVPRSTFFRWKATGRAPRTIKYPNGSLYVRRRDLDTWLNDHEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3A4</accession>
    <name>F4F3A4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cbs domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_08550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08550"/>
    <dbReference type="EnsemblBacteria" id="AEB42828">
        <property type="protein sequence ID" value="AEB42828"/>
        <property type="gene ID" value="VAB18032_08550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08550"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893750_0_0_11"/>
    <dbReference type="OMA" id="ERRHMAL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="66"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="31997" checksum="18EFE5EC42E2B26F" modified="2011-06-28" version="1">MVVRAVDGGLRLVTALLGTGPAAGRERISEAELRDLVAANTVLDPVGRRIIDEVLVAGASLVREVMMPRTEVVFLSAALTLAEAEPLVRAGMHTRYPVVDGTHDDVVGFVHLRDVLWHPDRDPDTTVGALVREVKRLPASKRVLAALTEMRREGHHLAVVIDEYGGTAGIVTCEDLIEELVGEIHDEYAEVPEPELAGLPAVVEGRLNLADFAERTAVVLPVGPYETVGGFVMAALGRLPRPGDEVPVPDPSGSGGGWLLRVLTLDGRRVARLAVTAGRLPEQRRTVGRSASRTGPASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3F1</accession>
    <name>F4F3F1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731546.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08785"/>
    <dbReference type="EnsemblBacteria" id="AEB42875">
        <property type="protein sequence ID" value="AEB42875"/>
        <property type="gene ID" value="VAB18032_08785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08785"/>
    <dbReference type="eggNOG" id="ENOG50339C4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087212_0_0_11"/>
    <dbReference type="OMA" id="FGWPEPY"/>
    <dbReference type="OrthoDB" id="1438002at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="245" mass="25433" checksum="F906DAAD57D4FDAD" modified="2011-06-28" version="1">MTPEQVAAASKPAVLALGDAYSRCPTTLRRARLLGISGWAFYITGRAGALGDVRAETVAAALGFIAPDAVADGWDAAARTVRPLEVAAASLVECCRWGEERLADLPHLDRLVDLVERVVAAADASAMPLFAAWRAMPPPATSAGARLAAGLRLLREHFTGAHLVAVRASGMSPLEAVLAGPEGESGAIACGWPPPYPPVGPLVRRRLWAEAVTNRLVAPAFVALGPTGGAELVELLAATRAHTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3M7</accession>
    <name>F4F3M7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ribH</name>
        <name evidence="8" type="ordered locus">VAB18032_15115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15115"/>
    <dbReference type="EnsemblBacteria" id="AEB44135">
        <property type="protein sequence ID" value="AEB44135"/>
        <property type="gene ID" value="VAB18032_15115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15115"/>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_1_2_11"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="15281" checksum="56DEAD90BC9C4B72" modified="2011-06-28" version="1">MTVGVVAARWHGELTDHMLDRAVAAAQACGAQAVVARVAGSVELPVVAQALARRCDVVVALGVVVRGATAHFDYVCRSVTDGLTRVALDEGKPVAHGVLTVDTLDQARDRAGLPGSAEDKGWSATVAALDAALAIRGVSTGGNQRVGFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3T8</accession>
    <name>F4F3T8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21445"/>
    <dbReference type="EnsemblBacteria" id="AEB45389">
        <property type="protein sequence ID" value="AEB45389"/>
        <property type="gene ID" value="VAB18032_21445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21445"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_20_11"/>
    <dbReference type="OMA" id="YGFSEAF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="52" mass="5510" checksum="2F52DB8A15213A0C" modified="2011-06-28" version="1">MTLAADMLADTTATVAAVARRIGYADAFGFSAAFKRVNGVSPSQHRKLARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3U6</accession>
    <name>F4F3U6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_21485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734050.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21485"/>
    <dbReference type="EnsemblBacteria" id="AEB45397">
        <property type="protein sequence ID" value="AEB45397"/>
        <property type="gene ID" value="VAB18032_21485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21485"/>
    <dbReference type="eggNOG" id="COG3583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112855_0_0_11"/>
    <dbReference type="OMA" id="KQERRCD"/>
    <dbReference type="OrthoDB" id="1800509at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307396" evidence="3">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="4">
        <location>
            <begin position="71"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="21562" checksum="ED442F54D28C5ECB" modified="2011-06-28" version="1">MFVLIGAVALVLLCCGGVTISALIAQPGESPKQQDLAAEAVPSARTDDPSSPTTAAAPTPSQQATPTQSPTPVAIKRTITVTKKVPYKTRTVNDSSLAKGTKKVRTPGVPGVKTLTYEVTVIDGEETAKELIKSEITKQPVTRVVRIGTKEAPRCDPNYAGACVPIASDVDCAGGSGNGPAYVEGPVRVIGDDIYDLDRDGDGIGCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Y3</accession>
    <name>F4F3Y3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_27781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735279.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27781"/>
    <dbReference type="EnsemblBacteria" id="AEB46629">
        <property type="protein sequence ID" value="AEB46629"/>
        <property type="gene ID" value="VAB18032_27781"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27781"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_1_2_11"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="3">
        <location>
            <begin position="5"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="34332" checksum="91EAD4947EEF5A70" modified="2011-06-28" version="1">MLAVLCPGQGSQKPGFLTPWLDLTGVEDRLRSWSTLAEVDLVHLGTKADADEIRDTARTQPLLVAAALLAAEQLPLTEVALTAGHSVGELGAAALAGTLSTEAAITLAGVRGREMAAACALEPTGMAAVLGGDPDEVVAVINGHGLHAANRNGSGQIVAAGAVAGLEKLAAEPPTRARIIRLQVAGAFHTPYMAPAETALASVADGITPDDPTRILLSNLDGAPVDDGREVLQRLVRQVTAPVRWDLCMATLAELGVTAVIELPPAGTLAGLVKRELKGNGAPEIVTLNTPDDLPAARDLIARHGTTARQEPGSRLDSNESRDETDRRESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4F404</accession>
    <name>F4F404_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA polymerase III subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_27886</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27886"/>
    <dbReference type="EnsemblBacteria" id="AEB46650">
        <property type="protein sequence ID" value="AEB46650"/>
        <property type="gene ID" value="VAB18032_27886"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27886"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066011_0_0_11"/>
    <dbReference type="OMA" id="HDFPDYR"/>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH merR-type" evidence="10">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="396" mass="41533" checksum="BD0A465DEC58A7D3" modified="2011-06-28" version="1">MDSDLRSIGELARASGLTVSALRFYDAAGVLVPAWVDPVTGYRRYTDDQVAPARLVAGLRRVGMPVAEIAQAVRAEPALVHRLLDTHLRRLEQGLADARREVSRLRSLLPADQPGITRLTLTGAALAAAVDAVRFAVGTDPTVPALTGVLFDVTDSGLELVATDRHRLAVATAEATVHGPAVRTLLPLDTVDALRHLLDASAGAGAGAGAGADRAVVELTVSGSSLVADVAGHELRATALPYDFPDYHALLPRSGAAGPTRRVPVDAEWLVTALRAGGPTVVREYAGRSWPVTVLGLGPPDRLRLLGPDDLPGPDDLRDPDDLPDPDRPGLAAGADRAGADGTELRVGVNGEYLLDALDAAGGRHLTLELDSPLTPLTIRRPDDEGAFSILMPIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F472</accession>
    <name>F4F472_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sss sodium solute transporter superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_04015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736517.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04015"/>
    <dbReference type="EnsemblBacteria" id="AEB47885">
        <property type="protein sequence ID" value="AEB47885"/>
        <property type="gene ID" value="VAB18032_04015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04015"/>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_8_3_11"/>
    <dbReference type="OMA" id="GTTWVQM"/>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="558" mass="58235" checksum="38B62BE76935CE90" modified="2011-06-28" version="1">MNSVVLAAEAGNTTARNLTIVLFLAFVAATLAITIWASRQTKTATDFYAGGRSFSGFQNGMAIGGDYMSAASFLGIAGIIALYGYDGFLYSIGFLVAWLVALLLVAELLRNSGRYTMADVLAFRMRQRPVRTAAAVSTITVSIFYLLAQMVGAGALVALLLGIRPGTTFLGMDADTAKVATIIMVGALMIIYVTVGGMKGTTYVQIVKAFLLMGGALLMTLLVLAKYKFNLSSLLGDAAASSGQGTAFLEPGLRYGVEVAGNATQTFYNKVDLLSLGIALVLGTAGLPHILIRFYTVPTAKAARKSVLWAIGIIGSFYLLTLALGFGAAALVGGDAIREQDRAGNTAAPQLAEALGIDFFGGELGGAALLAIIAAVAFATILAVVAGLTLASSSSLAHDFYANVVKRGSASERQEVNVARISALVIGAVSIALSIYAQNLNVAFLVALAFAVAASGNLPAILYSLFWKRFNTSGAVWAIYGGLLAAVVLVFFSPVVSGAPTAMFPDHDWQWFPLSNPGILSIPFGFLCGWIGTVISKESDEEKYAELEVRALTGAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4A8</accession>
    <name>F4F4A8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736553.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04195"/>
    <dbReference type="EnsemblBacteria" id="AEB47921">
        <property type="protein sequence ID" value="AEB47921"/>
        <property type="gene ID" value="VAB18032_04195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04195"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_5_0_11"/>
    <dbReference type="OMA" id="YWLAWPG"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="227"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="452" mass="47483" checksum="F0BDCEDD32CE46F0" modified="2011-06-28" version="1">MLAVLGFVATLALITGLIHLYLWKRLVKDTTRPGRWRRIGTVTAVVLALLVPATMMGTRAGMYWLAWPGYVWLALMFYLLVLLVVLEVPMLVTRLVLRRRTAVAAPEPVLVGPASTPGTATTTGTTTTVGATTTTGTTTTTTTAADGPATPGTPPTADEASEPPAAGAIGPDHDPGRRLLLARGAAIFAGLTAAGLVGSGVRTAMGPPRLDRVQIPLAKLPRSMDGLRIATVSDIHIGPLRGRLHTERIVAAINRLDADLVAVVGDLVDGTVAELGEAAAPLRDLRARHGSYFVTGNHEYYSGVEEWVAEVDRLGLRVLQNERLEIATRNGVLDLAGVNDVSAAGTGVAAPADYAAALADRDPSRPVVLLAHQPVAAFEAAKYDVDLQLSGHTHGGQIVPFNLLVRLEQPVVSGLGEVDGTKVYVTNGAGFWGPPVRVGAEPQITLVELRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4G3</accession>
    <name>F4F4G3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731592.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09015"/>
    <dbReference type="EnsemblBacteria" id="AEB42921">
        <property type="protein sequence ID" value="AEB42921"/>
        <property type="gene ID" value="VAB18032_09015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09015"/>
    <dbReference type="eggNOG" id="ENOG503277J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2248924_0_0_11"/>
    <dbReference type="OMA" id="HFAWIRR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="104" mass="11081" checksum="F88C5664AF3005BE" modified="2011-06-28" version="1">MDQLPTTSLVLVHPGPGWDHSQPLAAQRNAAGHFAWIRRQVDAGTAVVAGPIWRHDERLTGDLVGALVLALPPGKAADLTATDPAVIGGQLTMTTHPYHQVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4K3</accession>
    <name>F4F4K3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731632.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09215"/>
    <dbReference type="EnsemblBacteria" id="AEB42961">
        <property type="protein sequence ID" value="AEB42961"/>
        <property type="gene ID" value="VAB18032_09215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09215"/>
    <dbReference type="HOGENOM" id="CLU_203087_1_1_11"/>
    <dbReference type="OMA" id="EYVSARN"/>
    <dbReference type="OrthoDB" id="2050366at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012869">
        <property type="entry name" value="RHH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07878">
        <property type="entry name" value="RHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_5" evidence="1">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="67" mass="7734" checksum="7D190A486D6C0824" modified="2011-06-28" version="1">MVTTVNLPDGLHERLKQLAEQEHRSMNATIVVAVEEYVSARNHRARVRDLAREVAERDAELLRRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F501</accession>
    <name>F4F501_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21950"/>
    <dbReference type="EnsemblBacteria" id="AEB45490">
        <property type="protein sequence ID" value="AEB45490"/>
        <property type="gene ID" value="VAB18032_21950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21950"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026520_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="29288" checksum="CB1C23CDA8F389E0" modified="2011-06-28" version="1">MTKVMIIGDVGGCADQLSQAVASAQADPDAVMIQVGDLIDRGPDSPGVLTFVRQRLKDPRRWIQLVGNHESQYLGAEMFWPQRLPDEDAALLKSWWLRDRLRVAAAVRTVDGEELLVTHAGLTVDAWRRLGEPVTAATTVVMVPDGARHAPRRRAIRFRRRIPESRPVVVAPGRQGPGPRLPIRVGSRSPLMRCGRTGSQPLAPVPECCGADSGRACASPVSSPPRSAFTAPTVRYVTSTYLMSGSPVASLWLSATVSLPQQWSGAAKSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F502</accession>
    <name>F4F502_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734144.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21955"/>
    <dbReference type="EnsemblBacteria" id="AEB45491">
        <property type="protein sequence ID" value="AEB45491"/>
        <property type="gene ID" value="VAB18032_21955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21955"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946445_0_0_11"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="32083" checksum="B87EDC604CA4BA8C" modified="2011-06-28" version="1">MELVVDAGDVSLPATLDVPVDGPARGAIVVLHGSGEPRRSYFLYEHLARVFPAAGVAVLRFDRRPRERGDVPYAVQADDALAAVAQVRRHVGDVPVGLWAWSQGAWPASAVAARRPELISFLVLVAGSGVSPAAQMRYGTAQQLLLNGYASAELADLTRLRETLENVVRGHIDRTTAQAVIDGYADRPWFSLAHIPRDLDDHPGTWADMDHDPEPVIAQVRCPTLLFYGEADEWTPADDSIAVWRRAAATDDLTVHRLAGCTHLPTAGGAEALESISSDYHSTMLTWVQQRMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F528</accession>
    <name>F4F528_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28196"/>
    <dbReference type="EnsemblBacteria" id="AEB46710">
        <property type="protein sequence ID" value="AEB46710"/>
        <property type="gene ID" value="VAB18032_28196"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28196"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070742_0_0_11"/>
    <dbReference type="OMA" id="ERRTRMQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="36176" checksum="E4E103C8FA06CA67" modified="2011-06-28" version="1">MLRGMRTHPPEFSELAERQQQIVSRTQLLACGFDDMYLYRQTRRALWQRVLPATYALVTGTLTDEQRRISAALYAGGEAQLTGLAALTWYGFRQSPRSDDVQLIVPHHARRRSAGFAVVSRALALDDRARATPLYPVCSPARAVVDAARDLRQLRPVRAIVAEAVQRGYADLTSLDEEIRRARRSRTALIRKAFEEVAAGTRSAPEAELRECLAGSSVLSEIHWNPRLLGADGTSLPTPDGYLADAAVALEVDSQEYHFRPADWTRTLDRHNELSRHGILVLHFTPAQIRREPRRVRRTVEDAYDSRRGVGATARVCVGQPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F573</accession>
    <name>F4F573_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsT</name>
        <name evidence="9" type="ordered locus">VAB18032_28421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735405.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28421"/>
    <dbReference type="EnsemblBacteria" id="AEB46755">
        <property type="protein sequence ID" value="AEB46755"/>
        <property type="gene ID" value="VAB18032_28421"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28421"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_0_1_11"/>
    <dbReference type="OMA" id="GVIHKNA"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="88" mass="9713" checksum="33F68F08D12605AB" modified="2011-06-28" version="1">MANIKSQIKRNRQNEKRRLRNKSVKSSLKTAIRKFHEAAEAGDTEKATVLMQEASRKLDKAASKGVIHANQAANRKSAIAKRVASLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5D3</accession>
    <name>F4F5D3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736612.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47981">
        <property type="protein sequence ID" value="AEB47981"/>
        <property type="gene ID" value="VAB18032_04495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04495"/>
    <dbReference type="eggNOG" id="ENOG5031CHP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1407879_0_0_11"/>
    <dbReference type="OMA" id="DGCAWIA"/>
    <dbReference type="OrthoDB" id="1411491at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="20700" checksum="B726CE692DC12B28" modified="2011-06-28" version="1">MGLDNVAVQWPRTGRFYDPVAPAEFVDFGEIVDVPGISAPTAALAELIAKTGTVRATAYTEVVDLILGLDGVLYATEAAAEDEDPVIDPDGCAWIASGIERFVAAHRPHGEAVSFESVGVVLRSLLSDGRLAEQQLRWLDSRLEALRDDSGAAPQWTFTCAELSVVAAFYRRCADRGFAVYAESAAPRRAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5F0</accession>
    <name>F4F5F0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_09320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731653.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09320"/>
    <dbReference type="EnsemblBacteria" id="AEB42982">
        <property type="protein sequence ID" value="AEB42982"/>
        <property type="gene ID" value="VAB18032_09320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09320"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_1_11"/>
    <dbReference type="OMA" id="DWSGIYS"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017535">
        <property type="entry name" value="Asparagine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03104">
        <property type="entry name" value="trio_amidotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="594" mass="64860" checksum="092EF93F82278EF7" modified="2011-06-28" version="1">MCGLAGEFRTDATRADVIAVERMAATMCDRGPDGSGVWSNGPVALGHRRLKIIDLSAASGQPIVDSTTGLSAVFNGCIYNYRELRAELSAKGHTFFSTGDSEVVVKAYAEWGLDFVDHLIGMFAVAISERDSGRLVLARDRLGIKPLYLAESAGVLRFASTLPALLAGGGVDTTIDPVALAHFLSFHSIVPPPRTILRGVSKLPPATVRVYEPDGRSHERIYWNPPFLRRDEHADWSEKDWQDALLESLTTAVRRRMVADVPVGVLLSGGLDSSLVVALLAGEGQRGLSTFSIGFDAVGGREGDEFRYSDVVAKTFDTDHHQIRVAAQDLVPPLEAAVAAMSEPMVSHDCVAFYLLSQEVSRHVKVVQSGQGADEILGGYHWYPPLHRIDREQALDTYARAFFDRDAAGLAQVLNPDWLAEGDPAREFVAAHLAAPGAQTAVDAGLRIDTQIMLTDDPVKRVDNMTMAHGLEARVPFLDHEFVELAAACPPELKLAQGGKGVLKEIGRRVLPHEVIDRPKGYFPVPGLTHLEGKLLDRVRDALYAPEARRRDLFRPDYVNALLDAPNAELTPLNGNKLWQLGLLEMWLQSHGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5G8</accession>
    <name>F4F5G8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_09410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731671.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
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        <property type="protein sequence ID" value="AEB43000"/>
        <property type="gene ID" value="VAB18032_09410"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="647136at2"/>
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        <property type="reaction ID" value="UER00491"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
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        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="358"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="178"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="284"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="475" mass="51042" checksum="890C58BD4AF75F19" modified="2011-06-28" version="1">MTIPYPNTQPMPVIAAVTPPSGASRPRVTFLGTGYLGATYAICYAELGYEVLGYDVDPDKIAKLNAGEVPIHEPGLDELLRRNLAAGRLRFSTDIAETADFGDVHFICVGTPQRADGMGADLSYVEASVTSLAQHLTRKALIVGKSTVPVGTADWVEQLVSKHSPADLGVEVAWSPEFLQEGFAVDDVLRPNRIVVGVKSEWANGMLYAAHKGVFDLAATEDREVPLVVTDFATAELVKVAANAFLATKISFINAMAEVCEVAGGDVTQLARAIGYDPRIGNRFLQAGLGFGGACLPKDIRAFQARAQELGAGEALRFLHEVDLINLRRRTRVLHLAAELLNRRYGPAGPDLSGTRIAVLGATFKPNTDDVRDAPALAVAALLRKAGADVHVYDPQGIDNARRAVPELTYEPGMAEAVTDADLVCVLTEWADFRNADPTVLGELVAGRRVVDARNCLDSTLWTQAGWEYRGLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Q8</accession>
    <name>F4F5Q8_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB44271">
        <property type="protein sequence ID" value="AEB44271"/>
        <property type="gene ID" value="VAB18032_15805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15805"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_5_2_11"/>
    <dbReference type="OMA" id="YGCEITR"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="23727" checksum="E39DCFB7C77DC5DB" modified="2011-06-28" version="1">MRTTTIGDVKVLLPDLEPDDLDTTTDLAGGLSEALVEGASWRGSHLEDVSIRSSLITGVDLSESTWEAGSFYGCEITRTDFSGATLTGITIERCAVTGSRFTGTRLTDVRLKDVLFDGCRFDYATLQRVAAAGSVAFTDCTLSNGAWSSCRLPRIALRSCDLAGLELDSCQFDGTDLRGSRLHDLKTPLDNLRGVTLDEDQLPDLTRLAVAALDLTVRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5R6</accession>
    <name>F4F5R6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nlp/p60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732943.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15845"/>
    <dbReference type="EnsemblBacteria" id="AEB44279">
        <property type="protein sequence ID" value="AEB44279"/>
        <property type="gene ID" value="VAB18032_15845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15845"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055280_1_0_11"/>
    <dbReference type="OMA" id="GQLGTPY"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="206"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="35610" checksum="E51181C4F9D6D35B" modified="2011-06-28" version="1">MTKVIIGVVTIVIVACFGLPMLLLSAVFGGSSHGCGIVAAPALRPTGSQPDIGTWDTEQLDIAATIVDVGVAKGVPRWGWVVAVATAMQESGLRNLPHLGDGNDHDSIGVFQQRPSQGWGTVAQLSEPAYQAGKFFEKLLTVPGWESMPLTQAAQTVQVSAFPDAYTRWTDDALHLVDQLAYTLTDCATDTLAALPDGFALPANTPPAVTTAIFWAANQLGTPYHFGGSCTDPHSGNPDKQCDCSSLMQAAYRAAGIAIPRVTTDQAKTGKPVADTALLLPGDLILIPGSQGTMTNPRHVGMYLGDGLIIQAPTTGDVVKITRLDSWINQIAAIRRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5S2</accession>
    <name>F4F5S2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15875"/>
    <dbReference type="EnsemblBacteria" id="AEB44285">
        <property type="protein sequence ID" value="AEB44285"/>
        <property type="gene ID" value="VAB18032_15875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15875"/>
    <dbReference type="eggNOG" id="ENOG5031QDQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382748_0_0_11"/>
    <dbReference type="OMA" id="PHTDSCR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="198" mass="21764" checksum="59E1A06C3FBBBABD" modified="2011-06-28" version="1">MLMLHLDTIGRWVALATGRTLDQHAADPIPAAAHLPEAAATLRHLRTELLLAVDRLRTLLINEDDLTASASTVAGSVETVRELAREYRYARNWIDTLIGDEARAAYAQTHPGQTVRRRYVNPGDTVLVVLPHTDSCRRQNLAGHTTRIRVGTSDARLRPPGSVNPLRLSHADAGIYRDPTEDRLYVLQTGDETAGAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5T1</accession>
    <name>F4F5T1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15920"/>
    <dbReference type="EnsemblBacteria" id="AEB44294">
        <property type="protein sequence ID" value="AEB44294"/>
        <property type="gene ID" value="VAB18032_15920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15920"/>
    <dbReference type="HOGENOM" id="CLU_3334355_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="38" mass="4047" checksum="C4044CD7D79FD589" modified="2011-06-28" version="1">MGSIDLTAGIWAVHVIYGMPARWGPGEVHRFGMAGAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F602</accession>
    <name>F4F602_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_22305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22305"/>
    <dbReference type="EnsemblBacteria" id="AEB45561">
        <property type="protein sequence ID" value="AEB45561"/>
        <property type="gene ID" value="VAB18032_22305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22305"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_13_11"/>
    <dbReference type="OMA" id="HTVMEPE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="980"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2354"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2336"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2341"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1015"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="2692" mass="292550" checksum="4F317E25C411EC42" modified="2011-06-28" version="1">MLRRLTGSLAEPEQDLIRRRPDGTHPLPLSYLQEHLWFLDRLNPGTSTYNLGATFRLRGRLEIGALCASLRDLVARHEALRTTVVDQDGRPVQVVHDAGAAVTVVDLSGTPDDERDSTVARWAREAVDRPFDLDRETLFRATIAVLGPQDYLLALTMHHICVDGWSSQTLLAELTELYRAAVTGTEPALGVPQVHYPDFAVWQRSRGDELLTGQLDYWQRTLRDLPTLAMPTDFPRPVVPSDRSESVTTVLRGAVVPALRELSRRRGATLFMTLVAAFDAVLSRYTGQDDIVIGTTTTGRHRPQLPEMIGHFVNMVVLRTDLGGNPTFDELLDRVQQTVLGAWRNQDVPFEKVVAAVRPDREAGRNPLFQVGLQLLPGAAAGAALDLPEVRAALVDAGLDRHPFDLSLTVREDDEALHITADFRTDLFAVPRIERLVGHLCTVLEAVAANSGTVLGELPMLTPIERERVLEAWQGARRPYLREPVHLQIAAQAARTPRTVALRHGDEQLTYRGLIERADRLAGYLRGRGVGHEDIVGVALERGIDTVVAFLATMNAGAAFLPLDLAHPRNRLAYQLDDAGAKVVISHSRVRDRLPDSTGWEPVWLDLDAAAIDAAPASADPSPVTESSLVYVLYTSGSTGRPKGVLIEHRALSNFVSWMTGVFELGPGDQMLQYAAVNFDLAEGEIFSALTSGATLVLAPEQLRSDPGSLSGVIEAEGITYLGAPPAVLSLIPSADYPLLRKILVGGEALPGDLVNRWRAPGRRFVNGYGPTEVTIGCSYYVCEHREWRGQPPIGRAMPNRFVYVLDRFDKPSPVGVPGEITVGGVGLARGYLNAPELTAARFVPNPFRPGELMYRTGDLGMWSETGQLQFLGRIDTQVKLRGVRIELTEIEACLASHPEVRQAAVLLRTDLPGGPRLVAYLVPGSRVPGEAELRAHLTRELPAGVVPGSYVVLDELPLTTVGKIDQAALPAPQLTEGRVPRTETERVLCELFAEVLGVNTVTIDDSFFDLGGYSLLVVRLVNRVRERLGAELEIRTIFDTPTVAGMAHTLDGGSGADDRDLAAPTEQPQVEAPVEQPQVAAPAGQPQVADAGAVPAGEPGRPERVPLSYAQRRLWFLAQMEGPSATYNVPMALRLTGPLDPDALQVALDDVVGRHEVLRTVYPQFDGEPTQHVVADAHVPLIRPDVTPGQLPHLLADAAATVFDLAVDLPVRAWLLPTGPQEHVLMIVLHHIASDGLSLLPLLTDLGTAYAARRDGSAPTWPPLPMQYADYTLRQRAQLGEVTDPDSPLGRQLAYWKRTLAQLPAALQLPADRPRPPVASYRGDLLTFPIDAELHARLLDLTRRHRVSMFMLLQAAFAALLTRLGAGTDIPVGAPTAGRAEADLDALVGFFVNTLVLRTDTAGNPTFAELLTRVRDTDLAAFAHQDLPFELLAEALNPPRAAGHHPLFQVVLQVNSGGAGGLPPLGDVTVTAELVDLHVAKFDLVLGAEESYTEARPAGILGSFEYATDLFDRDTVARLGARLVHLLDAVSRDPAQPLDAIDLFLPGERERVLDEFNRTDRPVPDTVLPDLFEAQVRRSPEATAVIADTGAVSYATLDEAANRLAHHLLAHGVTPGGIVAVAIPRRVELIVALYAVHKAGAAYLPLETDHPAERLRYAVRHSRPTLVLTTGDTELPDLGVPVVVLDDPRTRTELATRPATPPARDLHPRHPAYVIYTSGSTGRPKAVVVSHHAIVNRLAWMLHHYPLDATDRVLQKTPAGFDVSVPEFFGPHQVGATLVLAAPGEQADPGRLAARIRDDAVTVVHFVPSMLRTFLAEPAAATCTGLRRVFVSGEELPTAVQRRFQQLFDAELHNLYGPTEAAVEVSAWQCRADEPGPVPIGRPVWNTRLYVLDDQLNPLPIGVTGELYLAGRQLADGYQHQPGLTAQRFLPDPYGPPGARMYRSGDLARWRADGALEFLGRVDDQMKIRGLRIEPQEVEEALTRHTGVASAAVAAHPAPDGGAQLVGHLVPDPTAEPLLHRLAALRATESLPWQTLPDGTAVVAPDRATTQFLYRELFEDGPVSPARLELPADACVFDVGAHVGMFSLALHRAHPDVVTYAFEPVPALHRMLAANTALYGLTAQTFAHGLGDTEGEVDFTYYPHLSIMSGRYADTAADARVVQGYEGVSADSPHWAELRDERLRPERVTVALRTLSAVIDETAVSRIDLLKVDVERSELDVLRGIRDEHWPLIRQVLVETDNARSDEVGDLLARHGFAVTRHTPELLAGTGLVSLHAVRPDHPSRSAPPAQVGCPRTEAEFVAEVRDEARHVLPAHLVPQRLVLLDRLPLSASGKLDRSRLPAPGRDGGRGRAPRTRDEEIACGIVAELLHRDQVTIDDNFFDLGGHSLLTVQLVNRIAAATGRQLGVRSVFVTPTVAGLLSDASEHGGLDVLLPLRTTGDRAPLFCVHPFTGLSWGYAGLARHLESDRPLYGLQSPLLTDPDSAEADVAALAERYLERIRAVAPQGPYHLLGWSFGGLVAHEIAVRLRERGEQVGVLALLDAYPVPQQGPAAQPPTPAEVLGVLTGDPELRRTDHGLSVLPDDEELARLVREANPALAQLRTAEIAGIARAAAGHVEAMRHHLPRRYDGDLLFVTATEDRPEQAPTADVWEPYVGGQVTRVDVAANHWSMTEPAPLARIGAALRQRLDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F633</accession>
    <name>F4F633_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735434.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28571"/>
    <dbReference type="EnsemblBacteria" id="AEB46785">
        <property type="protein sequence ID" value="AEB46785"/>
        <property type="gene ID" value="VAB18032_28571"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28571"/>
    <dbReference type="eggNOG" id="ENOG5033P21">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125367_2_0_11"/>
    <dbReference type="OMA" id="AIWANLG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025327">
        <property type="entry name" value="DUF4233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14017">
        <property type="entry name" value="DUF4233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="12636" checksum="3B302F1D0677926E" modified="2011-06-28" version="1">MSGPEGPQQRRSGLRDPQRAVRGLGAGTLALEALVLLLAIQPIRLVGGDLSAAAIGAVVALAVAAAMLAGLMGRPWAWNAGTVLQGLLLLSGLLHWSLLVLGVMFALVWAYAWHVRRVILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6L7</accession>
    <name>F4F6L7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated Cse1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16195"/>
    <dbReference type="EnsemblBacteria" id="AEB44345">
        <property type="protein sequence ID" value="AEB44345"/>
        <property type="gene ID" value="VAB18032_16195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16195"/>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034285_0_0_11"/>
    <dbReference type="OMA" id="MTAWRRS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013381">
        <property type="entry name" value="CRISPR-assoc_prot_Cse1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09481">
        <property type="entry name" value="CRISPR_Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02547">
        <property type="entry name" value="casA_cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="553" mass="60603" checksum="02373B9D32A6701D" modified="2011-06-28" version="1">MTSPPERQGFSLVDQAWIPVLDVAGRRREVSLLGLFKQANDLRMIACELPTQSFAILRLALAVLHRATDGPPGEAAWRALWRGRQLPTADIVEYLDAFRDRFDLLHPQQPFYQVADLRAAKENTYGLERLIADVPNGMPFLTTRAGRGMESISPAEAARWLVHCQAYDSSGIKTGAVGDPQAKNGKGYPIGAGSVGWLGGVHLEGADLWETLLLNLVPVAPAWREADDRDLPVWEREPHTAAEEPASTRGPYGLLSLYTWQSRRIRLFGDADGITGALIANGDRLDWQDRHLLEPMSVWGRSAPREREQKRTPIYLPRPHDHGRALWRGLQTLLPAPPPPGGEPPQRLAPMVVQWLARLTVTGVVGTDFQTRTRAVSITYGAKQSVVDEVFSDALTMNVLLLVADSALRATAVDAAGDAEAAVTVLRRLADNLARAAGSRDTDSGAADRAAERAYALLDRQFRDWLARLGPDSDPAAERGQWQRLVWRAISRLGAGLVEAAGPTAWVGRAGKDRAGRDVHYSSSQAEAWFRSGLAKALPMGVESPQQRQEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6M4</accession>
    <name>F4F6M4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733012.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44352">
        <property type="protein sequence ID" value="AEB44352"/>
        <property type="gene ID" value="VAB18032_16230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16230"/>
    <dbReference type="eggNOG" id="ENOG5033XDS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640835_0_0_11"/>
    <dbReference type="OMA" id="CIKEHID"/>
    <dbReference type="OrthoDB" id="2125346at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="428" mass="46799" checksum="24C0EEFCD0912E8F" modified="2011-06-28" version="1">MDLRRALDIVAQPWTYFGVSDAQLCADVQAYADDDLGVRDVPALDGEAAVRPLDVLLRLAVATKPQYQTDLYEAHRHWSLLRYLGLFDSDSDGYLCLSSAGRRIVGNQRRVTSEELGIGFAVHRAQEWMAARWPGATTAGVIDIDVALSSGVIRVGAVTSSVVQRGRRRPDYLLIAESPGSEDRYHYAVVECKGTKGWRYGLDQLASACVQLRGVAVESRQPPGLAVGTVLADDRVYCRALELSPGRRGHHESATYPVQLPESFGDAAEVHVEREAFERIVHVDMDEGAPLSAEDLVGAGMQASWASLADFAGNDYAFQRWAPPVFRANLDRDVRARPQRVERQTRGGLDVVGVRNLITLPGGELEVVFGLAAEVDEALADRDANRVIEAQRRAASQRAQERDVASREPGDDVTAVSDDGAVLMLIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6N0</accession>
    <name>F4F6N0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_16260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733018.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16260"/>
    <dbReference type="EnsemblBacteria" id="AEB44358">
        <property type="protein sequence ID" value="AEB44358"/>
        <property type="gene ID" value="VAB18032_16260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16260"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_11"/>
    <dbReference type="OMA" id="RIWYITL"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="358" mass="39588" checksum="A1277EFFE35FE336" modified="2011-06-28" version="1">MTDAPVGIPVTATGLEPAPEPASSSRARNRKARKNAAKDPKRKITWDLVWAQRALLAMAVPLLLYQILFKYVPVYGWAIAFQDFKPARGSSPWPGPRSLWNQQWVGLENFHNLFTGVMGERFIRVVINTIGQSLLTLTVGTLGAIVLALLLNEVKNLPFKRVLQNITYMPHFLSWVIVASMASVALSLPSSGGFINQGLMNLHIIDQPILFLTEPNYFWGIVAGTNLWKELGWNTIIYLAAITAIDPSLYESAEVDGAGRFRKMFSITLPSIRPTIVVLLIINSGWILSTNFELPYFLGNGLVSDRSETIDVFVLRYGYELGNYSLAIVAGIFKTIVAVILVGAANQAAKRLNQETLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F787</accession>
    <name>F4F787_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,5-didehydrogluconate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731816.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10135"/>
    <dbReference type="EnsemblBacteria" id="AEB43145">
        <property type="protein sequence ID" value="AEB43145"/>
        <property type="gene ID" value="VAB18032_10135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10135"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_11"/>
    <dbReference type="OMA" id="NWVPLPK"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="279" mass="30739" checksum="4792EC0E72768EE6" modified="2011-06-28" version="1">MANIIPTVTLNDGNTIPQLGFGVFQISPADSTEAVRRALDIGYRHIDTAQGYGNEAEVGQGVRTAGLAREEVYLTSKLNNNAHRPADARAAFQASLDALRTDYLDLFLIHWPVPTRYDGDFVSTWKVLEEFKADGRARSIGVSNFQVPHLERLAAETEVVPAVNQIEAHPYLSNDEVRAYGAKNGIVTEAWSPIAQGAVLDDPTITDIAAQLGRTPAQVVLRWHIQRGDVVFPKSVTPTRMAENFQIFDFALDEATMERITRLDRGEDGRTGPHPDTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7B4</accession>
    <name>F4F7B4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731843.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10270"/>
    <dbReference type="EnsemblBacteria" id="AEB43172">
        <property type="protein sequence ID" value="AEB43172"/>
        <property type="gene ID" value="VAB18032_10270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10270"/>
    <dbReference type="eggNOG" id="COG3212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1531900_0_0_11"/>
    <dbReference type="OMA" id="MRITKRA"/>
    <dbReference type="OrthoDB" id="2102526at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309138" description="PepSY domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="17953" checksum="EF04126F0A62A751" modified="2011-06-28" version="1">MKRNPLMLASVGGAAAVLAATGVFLGVTAADSDRTQQTTLTAATSAPTTAGVPDDDASSAAPAPPSDPTVTGTPVAPQSPATPTEGATSGSQDAVSAERAGELALAKAGGGRITEIDRDREDGRPVWEVEIVNGDVEHEIEIDRETGAVLKAEQEPVDDDDDDDRDDDDDDRDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7R2</accession>
    <name>F4F7R2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein LuxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22995"/>
    <dbReference type="EnsemblBacteria" id="AEB45699">
        <property type="protein sequence ID" value="AEB45699"/>
        <property type="gene ID" value="VAB18032_22995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22995"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410391_0_0_11"/>
    <dbReference type="OMA" id="RIWLVER"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="605"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="672" mass="71703" checksum="6028750EBCF8A913" modified="2011-06-28" version="1">MPEASVQRPKMSTGGSPATSDIERYVLRVVAIADAPCELWFLDRLLAHAGVPTWPTLDATLEDLLCRGTLVDSPAGLRLASPRLRDAVLAETPVSTQRGLRESAAEALADAGRPAQAARHLLRAMPTTAQRARALAARLATDPAVGPTLSADLLLAGGPPGTADRLLDWLVATADNLFLAGRLAEAMHLLRTELAVDRYGPCQRALLLGRLGAYYATRRPSLSMTYLERALDQHLDGAQRSWTLAMRASVAARFGYDDSGDLLAEAQQAHRAVPTADGEIRLALARAARATAAADLPSASRILQDVDADAPAARSQLVFLRVDRIANQLSLGRYTDARSALDAVTDEIDTLGGVARPLVTALDCVARLAVGEFAEAGARARLALDGPQADALTDEARATLLATVVEDLLRRGEVSMARALLTPEKPALAWPDGLQWFHLGAAAAADPEPERHAPLLRAILEMSNRSAAPLLLVPHHGPRLVRTALLLGDRQHAQILSSHLKRVAGTVNNRLWQGIAHHADGIITGDPAALATAVARLRTTAARPALADALFELGRSARVPREEAIDVLDECAALYARLGATGDHDRARQHRQQLGAGTRTRNAVRPDGPAALTPAEARVAELLAGGATKQQAAAELFISFHTVDTHLRAIYTKLGIRSRVQLARLWDARPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7S4</accession>
    <name>F4F7S4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734363.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23055"/>
    <dbReference type="EnsemblBacteria" id="AEB45711">
        <property type="protein sequence ID" value="AEB45711"/>
        <property type="gene ID" value="VAB18032_23055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23055"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098980_1_0_11"/>
    <dbReference type="OMA" id="RPDGWWK"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="125" mass="13075" checksum="A9E3F4CBA85F14A5" modified="2011-06-28" version="1">MNATPLLIVDAANVVGSRPDGWWRDRAGATARLRDTLVPLGGQGVPPELPPPVEVVLVVEGAAREVPGVDGVRVVSAAGSGDDAVVELVAGAGDRRRLVVTADRALRDRVTVLGAEVYGPRWLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7T1</accession>
    <name>F4F7T1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734370.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23090"/>
    <dbReference type="EnsemblBacteria" id="AEB45718">
        <property type="protein sequence ID" value="AEB45718"/>
        <property type="gene ID" value="VAB18032_23090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23090"/>
    <dbReference type="eggNOG" id="ENOG50333DJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151909_0_0_11"/>
    <dbReference type="OMA" id="ATPGQHD"/>
    <dbReference type="OrthoDB" id="2091457at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="8983" checksum="9F14B487CAB39F01" modified="2011-06-28" version="1">MPLNDDDIQSTSGGGLEGPADGGATPGQHDGGADGSAEGPADGGATPGQHDGGADGSAEGPADGGATPGQHDGGADGSAEGPADGGATPGQHDGGADGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F853</accession>
    <name>F4F853_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731885.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10480"/>
    <dbReference type="EnsemblBacteria" id="AEB43214">
        <property type="protein sequence ID" value="AEB43214"/>
        <property type="gene ID" value="VAB18032_10480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10480"/>
    <dbReference type="eggNOG" id="COG3217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_0_1_11"/>
    <dbReference type="OMA" id="GYPFLLI"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="116"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="29615" checksum="DC9519CC157FECF3" modified="2011-06-28" version="1">MRLSEINTYPVKGCRGLTHDESEVRPWGLDGDRRWMLVDADGVGVTQRDTTALVRVHAHPEAGGLRLSAAGHPDLLVPEPVGVPPVQVRTFRRRVLLVDALPAGPTADAWLGQVLDRPVRLVWLAEPARHIEPGRKKHDPGDRVSFADAYPVLLTSTASLAALGDWLTEAGADPVPMARFRPNLVVDGAPAWTEDGWEGRELRIGDVAFRAAGSSARCLVTTTDQETGVRGREPLRTLARHRNIDRQLLFGLNLVPLESGRISVGDPVLAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F894</accession>
    <name>F4F894_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10685"/>
    <dbReference type="EnsemblBacteria" id="AEB43255">
        <property type="protein sequence ID" value="AEB43255"/>
        <property type="gene ID" value="VAB18032_10685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10685"/>
    <dbReference type="HOGENOM" id="CLU_2014288_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="123" mass="12974" checksum="CF1FA3ABE8698A85" modified="2011-06-28" version="1">MRPDAPASARAGRSVDRTGDPSFAYRHRGCEGGWPAVCSLLLAGGGGLVGVPAGPPQAEASARREAAMTVYVSRYAATGELTSDAEDGLSASTRPDPDDPPLLTHVWRVVFERPARQNDADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8G7</accession>
    <name>F4F8G7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diaminobutyrate-pyruvate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17040"/>
    <dbReference type="EnsemblBacteria" id="AEB44512">
        <property type="protein sequence ID" value="AEB44512"/>
        <property type="gene ID" value="VAB18032_17040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17040"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="OMA" id="GSIQITH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="501" mass="54613" checksum="45534C154D33A754" modified="2011-06-28" version="1">MLTEFGLALKYVRARGNTLYYLADDGTEVGVFDAASGFGSLMFGHNNPEIVEHAKWLLDQQTPVHAQFSGYSFALNLAAELNAVIRRELQTDDKFFALFGNSGAEAVEISIKHAEMDRGARIAELKAEIDTHVEQARTAVADGARLSADAAALVGGADFDLLAAEVARRNAQTEARPPLFLALEGGFHGKLVSSVQLTHNAEFRGPFKALAAQARFIPRDRPELIAKVVEDERATLLDVTVQDGVVDLVERDFPVFAAFLIEPIMGEAGIFPLSAQLAGALREACDTIGVPLISDEIQSGMGRSGTFLAGTQIGLKPDYIILAKALGGGVAKLGVVLVNEHRYRKDIELIHTSTYGRDGFSSRLALKVLQMLEAEDGKAYQLAAERGAKAKAMMEAIKADYPDVVREVRGVGLMLGFELHDQSNSSSPEIREAVEHEALAFIIGGHLLRKHQIRIFSTASNLETMRFEPSIYLSDEEIARVDAGFRDICQILRDQDASRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8L7</accession>
    <name>F4F8L7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23310"/>
    <dbReference type="EnsemblBacteria" id="AEB45760">
        <property type="protein sequence ID" value="AEB45760"/>
        <property type="gene ID" value="VAB18032_23310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23310"/>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626371_0_0_11"/>
    <dbReference type="OMA" id="NICTLHA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="18076" checksum="22F6F79EAB88CD3C" modified="2011-06-28" version="1">MTSLHTWSPLWPNARSVVTSLANQGDPEPLRYFIAHAHPDDSCQRAALNYSAYWVGEIPYRQRDDSFMPSVRADWRGLHLLRHLVARLRPGHPFIDLNIHNAWALLAARRGLSADDPGTGHALVARAAVLLDSDDISMQSRQELTSIVYSLRADGITGTGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8N1</accession>
    <name>F4F8N1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734426.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23380"/>
    <dbReference type="EnsemblBacteria" id="AEB45774">
        <property type="protein sequence ID" value="AEB45774"/>
        <property type="gene ID" value="VAB18032_23380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23380"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_18_3_11"/>
    <dbReference type="OMA" id="WDAFWGQ"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="134" mass="14739" checksum="175444AB6AE1459F" modified="2011-06-28" version="1">MTPELDLIGMVSTDLARTVAFYRRLGIDIPADAEREPHVEVRLPNGLRLAWDDVATIRSFDPDWTPPVGGARTALAFRCADPAEVDRWYAELTAAGGHGHRPPWDAVWGQRYAVVHDPDGNAIDLFAPLPPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8U8</accession>
    <name>F4F8U8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735676.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29786"/>
    <dbReference type="EnsemblBacteria" id="AEB47028">
        <property type="protein sequence ID" value="AEB47028"/>
        <property type="gene ID" value="VAB18032_29786"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29786"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081768_0_0_11"/>
    <dbReference type="OMA" id="LWDIGPH"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="301" mass="31099" checksum="5C63882E16DF4EA5" modified="2011-06-28" version="1">MRFGLFGTGHWAAQTHGAALDAHPRAELVGVWGRNRDRAAALATRYGVPAYDEVDALIEACEAVAVALPPDVQAEIAVRAATAGRHLLLDKPLALTVADADRVVDAAADSGVASVVFFTARYQPEVAGFVAAAAAAGGWQTANVIRFASIFQPGSPYAQSPWRRERGALWDIGPHALAILLPVLGRVTRVAAGDGPGGLVHLLLTHDGGATSSVSLTLDAPPAAVAAEFTFYGDNGVETLPSGGASSATAFGVAIDQLLAEVDAGTRDHRCDVRFGREVVSVLAAAETARAQGTVIDLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F967</accession>
    <name>F4F967_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase component II</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730769.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04845"/>
    <dbReference type="MEROPS" id="C26.955"/>
    <dbReference type="EnsemblBacteria" id="AEB42095">
        <property type="protein sequence ID" value="AEB42095"/>
        <property type="gene ID" value="VAB18032_04845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04845"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_11"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="23256" checksum="43A9C90DE0A5A2F4" modified="2011-06-28" version="1">MRVLVIDNYDSFVFNLVQYLGQLGVECDVRRNDEIDLAEVGRLGEAGVLLSPGPGSPDRAGICLDVIREYAGKLPIFGVCLGHQAIGEAFGATVTRAPELLHGKTSQVHHDNSGVLAGLPDPFTATRYHSLAVLRETLPDELEVTGWTESGIVMAMRHRTLPIEGVQFHPESVLTEGGHLMLANWLATCGHPEALDRAPALAAEVDARRLAAFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9J4</accession>
    <name>F4F9J4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733227.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17350"/>
    <dbReference type="EnsemblBacteria" id="AEB44572">
        <property type="protein sequence ID" value="AEB44572"/>
        <property type="gene ID" value="VAB18032_17350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17350"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_2_2_11"/>
    <dbReference type="OMA" id="MLYRFGA"/>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="312" mass="31697" checksum="CD471F3AFFD3D1E5" modified="2011-06-28" version="1">MSLVSAFVPIWILTAVGYAACRWGLLGEAGASVLGRFVFHLAMPAALFLALSRMPLSGFAGRSLLAFGVSTAAVVGFGWVGASRLFGREPSERPIWGMVAGYVNSANLGIPIATQVLGSVSFLAEVVLLQVLVVAPVILIALDRHSDPAGRVRIRRIASLPVRNPVILASLLGVACSAADLQLPSAVDASLTLLSGAAAPTALVALGASLHHTVPSPAEVKPAEPVGVTELAVITALKLVAQPVIAYAAGLALHLSAPQLLAVVVCAGLPTAQNTFIFGQEYGVGEAVANRAVVVTTTLSLATLAAAAALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9V9</accession>
    <name>F4F9V9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">VAB18032_23935</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23935"/>
    <dbReference type="EnsemblBacteria" id="AEB45885">
        <property type="protein sequence ID" value="AEB45885"/>
        <property type="gene ID" value="VAB18032_23935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23935"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036138_3_0_11"/>
    <dbReference type="OMA" id="THINARF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB45885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="33187" checksum="F00DA98A4A056013" modified="2011-06-28" version="1">MSTLFSPLMAVIYAGISAILLFWHGAWQLVFDDAPLLGTNWSWVLGIVFLVLTVRAVLFPVFVKQIKAQRAMQALQPQIKALQEKHKDDRETLQKELVELYRAGQANPLMGCLPMLVQIPVFLGLFHVLRHLKPSMPEHMKTLYGWTVTQFDSASTATLFGAPIAANFRSGTQELALLGADGVTVRVVAAILIVIMIATTYLSSRQMILRTGWAEDPQQKMMQRLMLYGIPLSLLVSGLIFPIGVIIYWVTTNLFSLGQQTWVLRKYPPPPVNGVAAPTAATDAVASAPPKVGARPKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA58</accession>
    <name>F4FA58_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730793.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04965"/>
    <dbReference type="EnsemblBacteria" id="AEB42119">
        <property type="protein sequence ID" value="AEB42119"/>
        <property type="gene ID" value="VAB18032_04965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04965"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045535_1_1_11"/>
    <dbReference type="OMA" id="LNCGHPP"/>
    <dbReference type="OrthoDB" id="1021869at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="148"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="375" mass="38922" checksum="FD26361FCDBC58F2" modified="2011-06-28" version="1">MLSDVRTRLLQPGRSPLSPGSRAGLGAALVLLATVSAVELADGRAANYIALMVAAPFLAAALASWRVVLGAGTVASLLGAGFALAERTLSLSTAVAVAGIVLGTGIAAAVASVRERQAKQIAELSKLAAVAQQAVLRPLGPRVGALSVAGRYISSTARAEIGGDLYEAIETPYGVRMIIGDVRGKGLEAVRLASIVLGSYRHVAYERADLRAVVADLDRAVARNVGDEDFVTAALVEERGGTLTIVNCGHPAPLLLRGGAVIPLEPPAPAPPLGFMPVVRPRVERLEPGDRLLLFTDGLGEARRDGEFFPTADRAWRLLGHGTVADGLASLETALKEWVHGRLDDDIALVLMEYTGTASGVTAVVPSWEVGATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA60</accession>
    <name>F4FA60_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6458 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730795.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04975"/>
    <dbReference type="EnsemblBacteria" id="AEB42121">
        <property type="protein sequence ID" value="AEB42121"/>
        <property type="gene ID" value="VAB18032_04975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04975"/>
    <dbReference type="eggNOG" id="ENOG5033B4D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2451275_0_0_11"/>
    <dbReference type="OMA" id="RANVWWV"/>
    <dbReference type="OrthoDB" id="2031661at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045597">
        <property type="entry name" value="DUF6458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20059">
        <property type="entry name" value="DUF6458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6458" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="89" mass="9857" checksum="4FB7F660FEBBFD4C" modified="2011-06-28" version="1">MGIGSGIFLIAIGAILTFAIRANVWWVDLRAVGWVFILAGLGVLLTTLWFWQDRRKRARTLIVEENRLSHPTAMMPPPPDPPPPTAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA83</accession>
    <name>F4FA83_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730818.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05090"/>
    <dbReference type="EnsemblBacteria" id="AEB42144">
        <property type="protein sequence ID" value="AEB42144"/>
        <property type="gene ID" value="VAB18032_05090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05090"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_7_1_11"/>
    <dbReference type="OMA" id="GRRYSEH"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="145" mass="16214" checksum="7751B2474CC359C5" modified="2011-06-28" version="1">MDGFVGSDDPAYEAKVLMISVAARMAGMHPQTLRQYDRLGLVQAGRAAGGGRRYSVRDVVLLREVQRLSQDDGVNLAGIKRIIGLERLLEQAQQRVAQLEAELEAAYRRMAELESLARFPGRDLVPTNQTSTALVVWRPRRNPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA97</accession>
    <name>F4FA97_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730832.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05160"/>
    <dbReference type="EnsemblBacteria" id="AEB42158">
        <property type="protein sequence ID" value="AEB42158"/>
        <property type="gene ID" value="VAB18032_05160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05160"/>
    <dbReference type="eggNOG" id="ENOG50323PJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2756709_0_0_11"/>
    <dbReference type="OMA" id="DHLMPDE"/>
    <dbReference type="OrthoDB" id="2043784at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="70" mass="7825" checksum="A32AFA7FD704CADF" modified="2011-06-28" version="1">MGQPDEDFAPGDHLSPEERDLEAEPADAIEQAAVVDPTRADDEPHRGFEVDDWDAMEQARVVAADEDDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAA5</accession>
    <name>F4FAA5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="9" type="ordered locus">VAB18032_05200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05200"/>
    <dbReference type="EnsemblBacteria" id="AEB42166">
        <property type="protein sequence ID" value="AEB42166"/>
        <property type="gene ID" value="VAB18032_05200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05200"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_11"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="80"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="388" mass="39478" checksum="4897D4CB122CDE4A" modified="2011-06-28" version="1">MICAPGNPGIAGVAQQRSVDIVDPGAVAALAVEVAADLVVIGPEAPLVAGVADAVRAKGIPVFGPSAEAARLEGSKTFAKDVMTAAGVPTARAYTCTEAEGVGEALDEFGPPYVVKNDGLAAGKGVVVTDDRAVALEHAQECGRVVIEEYLDGPEVSLFVVTDGEAAVPLLPAQDFKRVGDGDTGPNTGGMGAYAPLPWAPAGLVDEVMRDVVYPTLTEMRRRGTPFSGLLYVGLAITAKGPRVIEFNARFGDPETQVVLALLETPLAGLLHAAATGTLADHPPLRWRAGAAVTVVVAAEGYPATPRTGDVITGADRPGIIHAGTRRAADGALLSAGGRVLCGTATGADLAAARDAAYQLVREVTLEGSHHRSDIAAVAIDGGVVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAK0</accession>
    <name>F4FAK0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732097.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11565"/>
    <dbReference type="EnsemblBacteria" id="AEB43427">
        <property type="protein sequence ID" value="AEB43427"/>
        <property type="gene ID" value="VAB18032_11565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11565"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_0_0_11"/>
    <dbReference type="OMA" id="TRWIDDR"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="161"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="359" mass="38411" checksum="9B4E6E0A42C9E5BC" modified="2011-06-28" version="1">MALHVRGVLLPDDEVRDLWLVGDRITFEPVPGAETIVDGGFVLPGLVDAHCHIGIARGATPITSLDQARALARIDRDAGVLAIRDAGSPFPYPELEDEPDLPRMVRAGRHIAPPRRYLRDIGVEVEAAQVVATVAEQAAAGSGWVKLVGDWIDRGVGDLAPAWDADTMAAAVAAAHAAGVRAAVHTFSESAVEIMVRAGVDSVEHGTGLSLDLIDLMARQGTALIPTMINIQTFGHIADQARPKFPGYADHMIALRDRFPEVVRSAYEAGVPIFVGTDAGGGIDHGLAAEEMLLLHEQAGMSTEDVLAAATWRAREWLGFPGLVDGGLADLVVYSDDPRRDLRVVREPARIVLRGRVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAK2</accession>
    <name>F4FAK2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11575"/>
    <dbReference type="EnsemblBacteria" id="AEB43429">
        <property type="protein sequence ID" value="AEB43429"/>
        <property type="gene ID" value="VAB18032_11575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11575"/>
    <dbReference type="eggNOG" id="COG2306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083275_0_0_11"/>
    <dbReference type="OMA" id="EDHFLDI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="24044" checksum="B8F87562D54FE798" modified="2011-06-28" version="1">MGRLVVHRNVRRGRIGWVRPARVVSDDERGLLLWVAEGSAVAGEVNAAGLGMRAVPFAQWLTPTFQLKQGRWNGPPLLKFLPAGAAHSVWWFRDAQGRFTGWYVNLEETGVRWDDGGLAGIDIIDQDLDVWVRPDRSWEWKDEGEFVERLAFPEHYWVTDEAAVRAEGKRVIALAEAGEFPFDGTWCDFTPPPEWETPQWLPAGWDRPPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAK7</accession>
    <name>F4FAK7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplS</name>
        <name evidence="8" type="ordered locus">VAB18032_11600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732104.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11600"/>
    <dbReference type="EnsemblBacteria" id="AEB43434">
        <property type="protein sequence ID" value="AEB43434"/>
        <property type="gene ID" value="VAB18032_11600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11600"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_1_11"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="118" mass="13522" checksum="EBF19241F8B65CF5" modified="2011-06-28" version="1">MNILDALDAQSKRTDLPDFRAGDTVKVHARVVEGNRSRVQIFQGVVIRRQGDGLRETFTVRKLSFGVGVERTYPINSPAIDRIEVVTRGDVRRAKLYYLRELRGKKAKIKELREKQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAK9</accession>
    <name>F4FAK9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_11610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732106.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11610"/>
    <dbReference type="EnsemblBacteria" id="AEB43436">
        <property type="protein sequence ID" value="AEB43436"/>
        <property type="gene ID" value="VAB18032_11610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11610"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_0_1_11"/>
    <dbReference type="OMA" id="ACDAYIK"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="23593" checksum="C95598FBFA9685DF" modified="2011-06-28" version="1">MIDEQTDKPRHSFWKELPILLGVAILVAVLVRAFVLQTFFIPSPSMENTLKIDDRVLVNKLVYNFRTPHRGEVIVFKAPVEWSGNPAGEDFIKRVIGVGGDRVVCCDAQDRLVINGVPLDEPYIFSFDGQRDKPADQEFDVVVPEGRLWVMGDHRSASGDSLEHYQQSGENVTAATIPEKDVVGRAFTVFWPFNRATLLTVPEGFEAIPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAW5</accession>
    <name>F4FAW5_MICM1</name>
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        <submittedName>
            <fullName evidence="5">Esterase, phb depolymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24150"/>
    <dbReference type="EnsemblBacteria" id="AEB45928">
        <property type="protein sequence ID" value="AEB45928"/>
        <property type="gene ID" value="VAB18032_24150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24150"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_1_0_11"/>
    <dbReference type="OMA" id="PHWCHGT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307765" evidence="3">
        <location>
            <begin position="32"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="4">
        <location>
            <begin position="336"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="446" mass="46842" checksum="DAE766ABC3D11625" modified="2011-06-28" version="1">MKKAIKLGWAALTAVALTALAALSIPSPASAATLTEVTNFGANPSNLRMYLYVPDRVAPRPGLLVAIHYCTGTGPALHSGTRFAALADQYGYIVIYPSVTRSSQCFDVSSPQALRRGGGSDPVGIMSMVDHVRSRYSVDPARIFATGVSSGAMMTNVMLGLYPDVFAAGAAFAGVPFACFATTNGSEWNSECANGQISRTPQQWGDLVRNAYPGYNGPRPRMQTWHGTNDDILRYPNFGEQVKQWTNVHGLSQTPTYTDSPQAGYTRTRYGGSGDHAPVEAISMQGVSHNLPVDAAQAIRFFGLNNPSSTPTPTPTPTPTPTPTPTPTPTPPPSPTLPPGPGCQVHYEVNAWNTGLTTSVTITNTGSTAINGWSLAFTLPAGQTITNGWNATYAPTSGAVTARNVSYNGTIAPKTSTTIGFQANHTGDAGKPGVFTLNGGSCYFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB06</accession>
    <name>F4FB06_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734621.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24355"/>
    <dbReference type="EnsemblBacteria" id="AEB45969">
        <property type="protein sequence ID" value="AEB45969"/>
        <property type="gene ID" value="VAB18032_24355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24355"/>
    <dbReference type="eggNOG" id="COG4907">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030943_0_0_11"/>
    <dbReference type="OMA" id="ARWHRSH"/>
    <dbReference type="OrthoDB" id="1293864at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="607" mass="65343" checksum="90A1658A04EFAF1A" modified="2011-06-28" version="1">MFVDLAVSAVALAGWFAVYGAIRFATRPANPTPAPATMELGDEPPALVNMLANRWTVTEDAAEATLLDLAARGFVELRQPGDDPMQTTLHLPASPPDESGLRPYERRVLARVRGLAAGGALPLTALTFRDQGQARAWNRRFRAEVVDHAREAGLSRRRFGPRVTALLSAAALVAAVFVWLAVTHYGLSHPAGDTRGLAAGFFTFAVLSALAAATPGERDTPRGAQVAARWLGVRDWLRGHEQFAELPPASVAIWDRYLGYGAALGTTHLTSALLDLGMGDRKLVWSSYGGTWHRVRVRYPHRSHHGRTLPGLLLRAVIIGGPAVFMLKLFGPVADPTPTSDYPGARAFSMVIFGLVVVAGLMLTRAVYTVVRAVVDPFTERTITGEVLWVQVWKSTAQGQNRPSRPWLYHLAVDDGSGDRTTAWGLPSQWAGDCHDGDTVTIRVRPWSRRVVAFAVVGHGRSRNLAEPVTHPSEVSAGPESPAYLITPEEIGQALGLAVHAPEAVDLPGPFTGVQFRAARDGQPVLTIQAVSGTVAQWIWRLNSRGQEVPGVGDGAYLLGERAVLRLGDRTLLVTLLGAARTRTASLPWLLTQAATRASADRPETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBB2</accession>
    <name>F4FBB2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730881.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42208">
        <property type="protein sequence ID" value="AEB42208"/>
        <property type="gene ID" value="VAB18032_05410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05410"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139738_0_0_11"/>
    <dbReference type="OMA" id="LAICDMR"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="128" mass="13988" checksum="BB2519556834F944" modified="2011-06-28" version="1">MTTLDRLAAEKYILLTTFRKDGRAVPTPVWAVRDGDALAVWTASDAGKVKRIRRSGEVTVAPCDVRGRPHGAAVPARATLYDPGATEHIRGLIKQKYRMIGRLTLLGSRLRRGQGGTVGIRLELTDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBK2</accession>
    <name>F4FBK2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_11750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732133.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11750"/>
    <dbReference type="EnsemblBacteria" id="AEB43464">
        <property type="protein sequence ID" value="AEB43464"/>
        <property type="gene ID" value="VAB18032_11750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11750"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_1_2_11"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="10"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB43464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="416" mass="44578" checksum="502E29200C8D7C47" modified="2011-06-28" version="1">MSFAFGVALFALGILVSVSLHEAGHMLTAKAFGMKVTRYFVGFGPTIFSFKRGETEYGLKGIPLGGFCKIVGMTPQDDDVEPGDEKRAMWRYPVWKRTIVMSAGSITHFGLAIFAAWLAAMTFGLPNPDFPRDEQQIRAEPAVIAIQDCVLPDTTYRECAAGDAASPAGAAGLRNGDRITSINGTPINNYGELLTTLRATTPGSTATIGYERDGQPGTTETTLATTKRPPIDNPDGPVTEVSALGVGLVLSTPGLVSYGPVEAVGATSTFIGDMAVATAKALQRLPEKIPALWTAITGGERDIDTPISVVGASVLGGEAVANNAWEIFIMLFISLNFFIGVFNLLPLLPLDGGHIAIAWFERARSWVYARLRRPDPGRVDYFKLMPFTYVVILIGGVFTLLTITADVVNPITLFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBP4</accession>
    <name>F4FBP4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732175.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11960"/>
    <dbReference type="EnsemblBacteria" id="AEB43506">
        <property type="protein sequence ID" value="AEB43506"/>
        <property type="gene ID" value="VAB18032_11960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11960"/>
    <dbReference type="eggNOG" id="COG1550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149981_1_0_11"/>
    <dbReference type="OMA" id="MYVGALE"/>
    <dbReference type="OrthoDB" id="1813824at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="97" mass="10583" checksum="E5BA3CD018F9ED67" modified="2011-06-28" version="1">MYTATAVFDLLLPGDSRSLKAKRSYVRPIVAALRRFEVSAAEVGALDLHGRAEIGVAVVAAEAAHAREVLDSCERMVAGRPEIELLSVRRRLHGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBT1</accession>
    <name>F4FBT1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733386.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18145"/>
    <dbReference type="EnsemblBacteria" id="AEB44731">
        <property type="protein sequence ID" value="AEB44731"/>
        <property type="gene ID" value="VAB18032_18145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18145"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_11"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="475" mass="48568" checksum="D576D2951C126136" modified="2011-06-28" version="1">MAGSAMADRRIMVPLSGVVLAQLLAMVDLNLTAAALPVIAADLGGTDRFAWVVTAAVLASTVTTPLYGKLSDVYGRRALLVAALAVLTLGSLLCGLAQSMNQLIAARAVQGAGAGGLMISAYAVYAELLDPRRLVRYQIVTATLVNIGTAFGPLAGGVLTDSFGWRWVFLATVPPSVLALLLVATLRLPPVAAGGRVDYAGMLWLGAALTTLVLLAGVAGTQWAFASPGVIALVVAAAVLLALWWRSAHRAADPVLPPALLRDRVVRSVAVQGWNTGAGMLVVVTFLPIVFVSLGASAADAGMYLLTLTFGTLVVSLAGTPLLARAARTQWFGVTGTVLLAAGTAWLAFTHPDLGPGGWAGWALATMAIGVGIGLGFQVYTLTLLRHAPRVHLGAALAMQSLSRQVGGSLVLAVLSAVFHSRLAAGGSTSTLDAAQTVFGLTALLLVVGVVAAVRLPVPSLTVAERSPVTTVETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC04</accession>
    <name>F4FC04_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46002">
        <property type="protein sequence ID" value="AEB46002"/>
        <property type="gene ID" value="VAB18032_24520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24520"/>
    <dbReference type="eggNOG" id="ENOG502ZWTF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1401080_0_0_11"/>
    <dbReference type="OMA" id="CGVHVYG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313776" evidence="1">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="19522" checksum="C95B0078D66C72A0" modified="2011-06-28" version="1">MWVAAILVAVSAGAAVVVRTAGSQAEPADLQGQILTRMRTILEQADPEQHNHAGHDLQQVANGEQTKPAVICGVHVYGYEPSEASKLADVQTVYGFHLCGVAEQKRTWDWAVKLAGPLIMDFSTDPPGIQVVEATEDVIFIDRLRQMFPPKYAEPAQKEALSPSEMVDLRRRYDAAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC08</accession>
    <name>F4FC08_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2, barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734658.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24540"/>
    <dbReference type="EnsemblBacteria" id="AEB46006">
        <property type="protein sequence ID" value="AEB46006"/>
        <property type="gene ID" value="VAB18032_24540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24540"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103066_3_0_11"/>
    <dbReference type="OMA" id="KNIPHSW"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="19120" checksum="9F8DB40FBBC7AD55" modified="2011-06-28" version="1">MDKQLPPKDDPIWTAARGFVARDDEGVLKLVNGGQEAARVKVTGDQTDGQLSLLAFDIAPGFGNRAHAHGAESEAFYVASGEFRFLNGNRTFEAGPGDFIYVPKNTRHGFKNLSSEIGKLLVFYSPAGAEQFFLKYGDDPDPAGNPPPAWTPEKFAEIAGALDAHHMIMLPDEDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCE0</accession>
    <name>F4FCE0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA</name>
        <name evidence="8" type="ordered locus">VAB18032_01175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735956.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01175"/>
    <dbReference type="EnsemblBacteria" id="AEB47319">
        <property type="protein sequence ID" value="AEB47319"/>
        <property type="gene ID" value="VAB18032_01175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01175"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_11"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="8"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="698" mass="76558" checksum="27291A718C27D1D5" modified="2011-06-28" version="1">MAAADALANVRNIGIMAHIDAGKTTTTERILFYTGITYKIGEVHEGGAVMDWMEQEQERGITITSAATKCEWKGHTIQIIDTPGHVDFTVEVERSLRVLDGAVAVYDGVAGVEPQTENVWRQADKYNVPRMCFVNKLDRTGADFFRCVQMMIDRLNATPLVLQIPIGAESDFIGVVDLVEMRALTWRGETQKGEDYAVEEIPAELADSAAEWREKLMETLADVDDAVMEKYLEGEEISVEEIKAAIRRATIAGKANPVLTGTAFKNKGIQPMLDAVVAYLPSPLDIPAIEGTATDGETPMQRKPSVSEPFSGLAFKIQTDKHLGKLTYVRIYSGTLESGSQVVNSTKDRKERIGKIYQMHANKREERSTAKAGDIIAVQGLKQTTTGDTLADPANPVILESMTFPEPVIEVAIEPKTKADQEKLSTAIQRLAEEDPTFRVKLDDQTGQTVISGMGELHLDILVDRMRREFNVEANIGKPQVAYRETIRRKVEKVEYTHKKQTGGSGQYARVIVSLEPLPLGNDAPTYEFANAVTGGRIPREFIPSVDAGAQDAMQYGILAGFPLVGVKLTLLDGQYHEVDSSEMAFKIAGSMVMKDAARKADPALLEPMMAVEVTTPEENMGDVIGDLNSRRGIIQAMEERSGARVVRALVPLSEMFGYVGDLRSKTQGRASYSMQFDSYAEVPASVAKEIIAKATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCH5</accession>
    <name>F4FCH5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730975.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05880"/>
    <dbReference type="EnsemblBacteria" id="AEB42302">
        <property type="protein sequence ID" value="AEB42302"/>
        <property type="gene ID" value="VAB18032_05880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05880"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_5_1_11"/>
    <dbReference type="OMA" id="DPRKRQC"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="215" mass="23724" checksum="B6E5E25E5DABDB9B" modified="2011-06-28" version="1">MSKTVVHVLRHGEVHNPDGILYGRLPGFRLSELGVQMAKAAAQGLADREVVHVVASPLERAQQTAEPIAAQFGLPVGVDERLIESANWFEGKRVSPGDGSFRDPRNWWVLRDPVTPSWGEAYRAIAERMFAALHAARVAAEGREAVLVSHQLPIWTLRRYVERKRLWHDPRRRQCGLASLTTFHFDGAKVVGIGYSEPAAHLVAMSPGARTAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCK8</accession>
    <name>F4FCK8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetate-CoA oxygenase subunit PaaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">paaA</name>
        <name evidence="1" type="ordered locus">VAB18032_06055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731008.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06055"/>
    <dbReference type="EnsemblBacteria" id="AEB42335">
        <property type="protein sequence ID" value="AEB42335"/>
        <property type="gene ID" value="VAB18032_06055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06055"/>
    <dbReference type="eggNOG" id="COG3396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879733_0_0_11"/>
    <dbReference type="OMA" id="MQPEANW"/>
    <dbReference type="OrthoDB" id="623539at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097266">
        <property type="term" value="F:phenylacetyl-CoA 1,2-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011881">
        <property type="entry name" value="PaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02156">
        <property type="entry name" value="PA_CoA_Oxy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="39312" checksum="2D7EE8062958EFBD" modified="2011-06-28" version="1">MYGNDFSGEDAPGGLLGEVEAAEAALRAAAERDRGTPGQDVDLAAYFAEVIDADQKIEPRDWMPEAYRRTLIRQIAQHAHSEIIGMQPEGNWISRAPSLKRKAILLAKVQDEAGHGLYLYAAAETLGISRDELVDLLLEGRQKYSSIFNYPTLTWADVGAIGWLVDGAAIVNQVPLCRCSYGPYARAMIRVCKEESFHQRQGYEILHTLAHGTPAQKAMAQDALDRWWYPSLAMFGPPDSDSTHSAQSMAWKIKRFSNDELRQRFVDMCVGQAEVLGLTIPDPDLRWNDERQAYDFTQPDYDELMRVITGDGPCNRQRMEHRRRAHAEGAWVREAAAAYAAKQVSKEKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCM1</accession>
    <name>F4FCM1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoD</name>
        <name evidence="8" type="ordered locus">VAB18032_06120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731021.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06120"/>
    <dbReference type="EnsemblBacteria" id="AEB42348">
        <property type="protein sequence ID" value="AEB42348"/>
        <property type="gene ID" value="VAB18032_06120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06120"/>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_11"/>
    <dbReference type="OMA" id="IMGTSME"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="156"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="441" mass="48900" checksum="61A23BB25E8AF285" modified="2011-06-28" version="1">MSASNYATERETTEGRVFNVTGGDWDDVVSGVDPINEGRIVVNMGPQHPSTHGVLRLVLELEGETVREARSVVGYLHTGIEKNLEYRNWVQGSTFVTRMDYLSPIFNETAYALAVEKLLGITDEVTERANTIRVLMMELNRISSHLVWVATTAMELGAINMMLYGFREREYILEIFELITGLRMNHAYVRPGGVAQDVPDEAIVKIRDFLKLLPKRLKEYEDLLSGQPIWLERTREVAVLDVTGCVALGVTGPVLRSAGLAWDLRKTMPYCGYETYEFDVPTHADGDVWGRYLVRMAEMRESLKLIEQAVDRLKPGPVMVADKKIAWPAQLAIGVDGMGNSLEHVAKIMGQSMESLIHHFKLVTEGFRVPPGQVYVAVESPRGELGVHAVSDGGTRPYRVHYREPSFVNLQALPAMAEGGLIADVIAGGASLDPVMGGCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCS7</accession>
    <name>F4FCS7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12285"/>
    <dbReference type="EnsemblBacteria" id="AEB43571">
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        <property type="gene ID" value="VAB18032_12285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12285"/>
    <dbReference type="HOGENOM" id="CLU_3031189_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="6456" checksum="C82D243F8F95C2C5" modified="2011-06-28" version="1">MKPAVRRRLVFRFNQDLGGPPQIKSGGNLLVERGAETETGYERRRTEDRAYDRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCW6</accession>
    <name>F4FCW6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733453.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18480"/>
    <dbReference type="EnsemblBacteria" id="AEB44798">
        <property type="protein sequence ID" value="AEB44798"/>
        <property type="gene ID" value="VAB18032_18480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18480"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129336_1_1_11"/>
    <dbReference type="OMA" id="IPGRANI"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="15002" checksum="0105AA8531879D18" modified="2011-06-28" version="1">MTTNSLGPQVSADDRAAVAALPERVVQAWAANDADTFAGLFTPDGTMILPGVTRKGRDDIRDFMAQGFAGPYKGTRVTGQPFDIRFLGPDVALLLTEGGVLAPGETEVAAERAIRASWLLVRTPNGWQLTAYQNSPRDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCW7</accession>
    <name>F4FCW7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CopC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733454.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18485"/>
    <dbReference type="EnsemblBacteria" id="AEB44799">
        <property type="protein sequence ID" value="AEB44799"/>
        <property type="gene ID" value="VAB18032_18485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18485"/>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348461_0_0_11"/>
    <dbReference type="OMA" id="YLVAYHA"/>
    <dbReference type="OrthoDB" id="1753926at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313804" description="CopC domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="6">
        <location>
            <begin position="36"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="21332" checksum="33D1C9431B0C6239" modified="2011-06-28" version="1">MSAGRRTLAIVTALASVGVALTVAAVVRQSDGTPARVLSVDPGDGAALTSAPDAVTLRLSTGADSVLSHVTVRDNTGNAVNDGRVRADGKTGLRQPVRLTDPGDYSIAYHITFSNGQDATGILRFSVGTGAPPQGIVDVPDPILDDADHAHGIDPLGATLLVIDGLVLVVVLALLLRRPARHRRPPARASTVSAASGHLDGSPDEPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD96</accession>
    <name>F4FD96_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25140"/>
    <dbReference type="EnsemblBacteria" id="AEB46126">
        <property type="protein sequence ID" value="AEB46126"/>
        <property type="gene ID" value="VAB18032_25140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25140"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_2_11"/>
    <dbReference type="OMA" id="IWPFWHR"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="166" mass="18007" checksum="B628E22A8F49D8CA" modified="2011-06-28" version="1">MLAAMEIRIATADDWSGIWPFLREIVAAGQTYTWPRDVGEDQARGMWLVPAPGRTVVAVEPDGTVLGSAKLTPNQLGPGAHVANASFMVAPWAAGRGIGRALGRHVLDLARADGYRAMQFNAVVASNTRAVALWRSLGFEVVGRIPEGFHHPDEGYVDLLVMYQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDD1</accession>
    <name>F4FDD1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735978.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01290"/>
    <dbReference type="EnsemblBacteria" id="AEB47342">
        <property type="protein sequence ID" value="AEB47342"/>
        <property type="gene ID" value="VAB18032_01290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01290"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_16_6_11"/>
    <dbReference type="OMA" id="CDQYKVS"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="73" mass="7892" checksum="634F61491770B7C9" modified="2011-06-28" version="1">MSEAAYLQVARDIREQVSSGQLKPGDKLPSFASLCDQYKVSNTVIRAAMLILKAEGLIDGRQGKGVYIANPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDF7</accession>
    <name>F4FDF7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01420"/>
    <dbReference type="EnsemblBacteria" id="AEB47368">
        <property type="protein sequence ID" value="AEB47368"/>
        <property type="gene ID" value="VAB18032_01420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01420"/>
    <dbReference type="eggNOG" id="COG5479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037318_1_0_11"/>
    <dbReference type="OMA" id="PKSWTHN"/>
    <dbReference type="OrthoDB" id="1478995at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3152" evidence="2">
        <location>
            <begin position="109"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="32161" checksum="D0902DCC44047AE9" modified="2011-06-28" version="1">MTGMVIPRSHRRQPGRHARRASRSGQGAGHRPKLAARLSVLVAVSAGVMLVAGGTGWLPGAADADEVQAVPPPVAAVVPPAEPQLSGPSSSAPPVVTPSPTAPVLQQPGRVPSGGRGRFDHDERTGPVLGKAGGLQRYRVAVEAGAGVDPAEFGLAVQVALTGPGSWVDSGRLRLRQVETSSRYDFTVYLATAATAGRMCAAGGVDIRVGGRPYTSCRAPGKVIINLERWRRSVPHFVEAKVPLSVYRTYVINHEVGHQLGNRHERCPGAGKPAPVMMQQTLFLKGCVANPWPYLDGRRYAGPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDK5</accession>
    <name>F4FDK5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_06220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06220"/>
    <dbReference type="EnsemblBacteria" id="AEB42368">
        <property type="protein sequence ID" value="AEB42368"/>
        <property type="gene ID" value="VAB18032_06220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06220"/>
    <dbReference type="eggNOG" id="ENOG50335W2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017429_0_0_11"/>
    <dbReference type="OMA" id="GIDIISH"/>
    <dbReference type="OrthoDB" id="552895at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03923">
        <property type="entry name" value="T7SS_EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="587" mass="61339" checksum="07C41AE9798D3F97" modified="2011-06-28" version="1">MSTGPGDRWRDHRPRAGQIVATQVALAAPVAALGRGLPAMLAAAALAGALLFLAWCRVRRRWLYEWLSIGLGYATRRRTVTPDGGPAALLDLVAPDTVRHPVELAGSSAVLLEDPGGVVALLELGDRADLLGDGGQQLPSPASLLPADPGDGPPVRVQLVLSATPVTGAGGGPAATSYRQLTQGRVAGWERAVLAVRVTRAEGWSEQAFRSTLASAVRRIVRRARPLTVRPLGEPAALRVFAELAHHDGQPVRESWQAVRSGGLLQTTFRLRRWPAPEAARHLVSRLLQLPATAVTVSLHADATATTGLTVRIGASTPAELSAAARALRALVTAAGGLVQRLDGAHLPGFADTLPLAPPVPSATGEGTGLELPYGSAGLVVGANRHGSPVTVRLFRPESTRVMIVGGVRAAQLVTMRAMALGCRVVVQTTRPQLWQPFVRGVGTPGEPIPLLPPGRQVETGPGTPLSPVLVVLDAPPPTGGPRPGAAWQTTLLVRDELTPADADALGRSDLAVLQPLSRTEAGIAGAALGLGDSADWLTRIRHDMVAVVNRRALRWAVLAGTALEAQVVGRPSRDSTPERVPPIARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE34</accession>
    <name>F4FE34_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19005"/>
    <dbReference type="EnsemblBacteria" id="AEB44903">
        <property type="protein sequence ID" value="AEB44903"/>
        <property type="gene ID" value="VAB18032_19005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19005"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="OMA" id="HEMIGHL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="399"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="489" mass="51718" checksum="D671AE12E78893EF" modified="2011-06-28" version="1">MPDLLDWRASLHPEQVAVEVHGVATLTFADWAAESSRLAAALRARGLRQGDRVGLLFGARDWTRFAVAYCGVLRAGGVAVPLSDRLAAGQLEYALTHCAATAVLHGDDTPAPPVPAGLPVWTCADLLTETAREHVDAPTARPGDLAQILYTSGTTGRPKGVAASHANLTVGAPQHPRRLALAHSRRFLHAFAIGTNAGQTMLLNALTAKAGALTLPRFTPLRFARLIEAPGTGTVFVVPSIAVELLDSGALRGRDTSGVQLIGSTAAPLAPAVAARLAEAFPAATIVNYYTSTEAAPAQTTMIYDPARRDAVGRPVGGQLMVADADGNPLPAGTTGDVWLRAPFTRAYYRDEAANRATFRDGWVRMGDVGRLDADGYLYLTDRHQDVIKTGAFKVSTLEVEAALHEHPLVAEAAVVGIPHPVLGSAVAAAVVLRPPAGPDDLTLPVVRGFLADRLADYQLPARLLVLDRLPHNEGGKVLKRQLTDLFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE63</accession>
    <name>F4FE63_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_19150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19150"/>
    <dbReference type="EnsemblBacteria" id="AEB44932">
        <property type="protein sequence ID" value="AEB44932"/>
        <property type="gene ID" value="VAB18032_19150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19150"/>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_3_0_11"/>
    <dbReference type="OMA" id="TRGECCR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017510">
        <property type="entry name" value="Release_fac_RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03073">
        <property type="entry name" value="release_rtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="392" mass="41984" checksum="7713E941AED4CD8A" modified="2011-06-28" version="1">MSELHLRQSMLPASGPATISVFASPTSWIESDAHTQCRQVAALDGMIHVAAMPDLHPGKGAPIGAAMTSRVLYPFLVGSDIGCGIAVFPIRLKRPVPEKLAARFPDLDRPLHPEHDADDPAWTVVSGEIPAGHVEGLGTVGRGNHFVELARIGAVLDPTHAGRLGLAAGDLVLVVHTGSRGLGEQILREHTERHGAGPAPDPQAYLARHDEAVRWGALNRRLLAARVAYALGAAPTEPVVDQCHNLVEVRDGSYLHRKGAAPGDGRDVLIAGTRGTPSYLVAAHAGPEANYSVAHGAGRKMSRADALCRGRAKHTVEELRRTPVGSLVVCGDRQLLFEEAPGAYKRIEQVIDDLVEHRLATPIATTVPLVTYKTADLAVGSRRDERRRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE91</accession>
    <name>F4FE91_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734809.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25295"/>
    <dbReference type="EnsemblBacteria" id="AEB46157">
        <property type="protein sequence ID" value="AEB46157"/>
        <property type="gene ID" value="VAB18032_25295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25295"/>
    <dbReference type="eggNOG" id="ENOG5031TCK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="AGHCVEV"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="6885" checksum="BE3981D98A1960A0" modified="2011-06-28" version="1">MADTTTVRWRKSSRSGNQGDCVEVADALPGGGVGVRDSKDPNGPVLTFSPTSWTTFTTSLRTPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEB0</accession>
    <name>F4FEB0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734828.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25390"/>
    <dbReference type="EnsemblBacteria" id="AEB46176">
        <property type="protein sequence ID" value="AEB46176"/>
        <property type="gene ID" value="VAB18032_25390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25390"/>
    <dbReference type="eggNOG" id="ENOG5030IIU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801546_0_0_11"/>
    <dbReference type="OrthoDB" id="2203755at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="346" mass="37084" checksum="4F3EBC9CC2F45F15" modified="2011-06-28" version="1">MNLTDLKRVLDERSRETAEQAVHRSRLHGVRAKVRARRRRRIAAWATAGVAVAAAVTFVLPGLRPDLTPTPAVSPSPTPTIEGFPEYANGARVVAARSAPLSARQVEVTVVPTTLDLVIFTRCDGVDENIAVERTVRVGSRVVADGTCHDGSLHPADWAGLGVTVGQPATVVLTITGAYQSGDAGEMGVPVPERGEVGLAIGARMPFDDYPLPPRPGVLTPLNQASWPAGCSETVCQNVIVIRSDPDDPTRPVRTELDWPTVTSIDMVSQTPGLLRVQVAGVQVAVGEWWDYQLTGAQMYGDADGQWKRDFDLDLRRGDRVRIEVVPAQVTGAWQVVLTPAVSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEK3</accession>
    <name>F4FEK3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01805"/>
    <dbReference type="EnsemblBacteria" id="AEB47445">
        <property type="protein sequence ID" value="AEB47445"/>
        <property type="gene ID" value="VAB18032_01805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01805"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042900_1_1_11"/>
    <dbReference type="OMA" id="PIPTDGY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="121"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="334" mass="36715" checksum="541EC00F355A160C" modified="2011-06-28" version="1">MSEPDMRRDETGPDNGQVARAQPDPARHNGRRPAAAGQPALPAEPHPPAVPDRPGDVWDQRIAGGLAFLRRRLAGDYEVDEFGFDPELTEAVFHPLLRRLYRDWFRTEVTGLENVPTEGAGLVVGNHSGTVALDALVLSTALHHEHPARRYLRLLGADLVFRMPVVSEIARKTGGTVACNPDAERLLRGGELVGVFPEGFKGVGKLYAERYKLQRFGRGGFVSAALRTGTPIIPVAIVGGEEIYPMLADIKPLARLLKLPYFPVTPTFPWLGPLGMVPLPSKWLIEFCPPIPTAHLVDSADDPLVVFNLADQVRETIQQTLHELLERRPDPFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEW4</accession>
    <name>F4FEW4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase, sigma-24 subunit, ecf subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_06920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06920"/>
    <dbReference type="EnsemblBacteria" id="AEB42508">
        <property type="protein sequence ID" value="AEB42508"/>
        <property type="gene ID" value="VAB18032_06920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06920"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_0_11"/>
    <dbReference type="OMA" id="REHRTKM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="407" mass="44650" checksum="F1A48A36843AC99B" modified="2011-06-28" version="1">MLHPGRVGDVAELVERIWRTDAAGMLGVLSRRLGDFDRAEEALSDALAEALARWPGEGVPERPAGWLVTTGWRKALDRLRRDAVGREKLARLAIEPPPEPGVDDRLATIFGCCHPALTESSRVALTLSAASGLSTAEIAAAFIVPVPTMAQRLTRAKRQLRERGVRFEAPQPHEYPDRLPAVLSVIYLVFNEGYLSSSRSAQRRELAREGVELARQLAGLLPGEPEAAGLAALLELHQARAAARFDSWGRIVLLDQQDRRRWDRPAIERAALRLRAAVRLGRTGPYQLQAGIAALHALAPSYADTDWTDVRALYDRLYAVDPSPVVLLNRAVATRFALGPAPALAEVEAVGDRLAGYHLWHAARADLLAALDRPAEALTAAERALELATNPAERELMSRRVGELRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEZ0</accession>
    <name>F4FEZ0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_12940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732370.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12940"/>
    <dbReference type="EnsemblBacteria" id="AEB43702">
        <property type="protein sequence ID" value="AEB43702"/>
        <property type="gene ID" value="VAB18032_12940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12940"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_11"/>
    <dbReference type="OMA" id="VEACDRK"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="435"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="477" mass="52387" checksum="151B1C0E2123DA8A" modified="2011-06-28" version="1">MSNPATPPAVGVLDERAPLTFPPGFLWGAATAAYQIEGAAAEGGRTPSIWDTFSHTEGRTVAGHTGDVACDHYHRVGDDVRLMAELGLKSYRFSVSWPRVQPGGSGPVNAEGLDFYQRLVDDLLANGIEPWLTLYHWDLPQELEDAGGWPARDTAARFAEYAQLMANALGDRVKYWTTLNEPWCSAFLGYGSGVHAPGRTDGAASVQAGHHLMLGHGLAVQALRATLPQAQLGVTVNLYPVTPASDAPGDVDAARRIDGLANRFFLDPMLRGQYPDDLVADLAKVTDFGHVRDGDLAVISTPMDLVGVNYYSRHVVAAPVPGEQPERYWRAPTNWPGSEDVRFVTRGVPVTDMDWEIDAPGLVETLRRVHEEYTDLPLYVTENGSAFVDAVIDGQVDDVERLAYFDAHLRAAHEAISAGVPLQGYFAWSLLDNFEWAWGYTKRFGMIYVDYDSQTRIPKSSARWYAEVIRRNGLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFW8</accession>
    <name>F4FFW8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731221.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07120"/>
    <dbReference type="EnsemblBacteria" id="AEB42548">
        <property type="protein sequence ID" value="AEB42548"/>
        <property type="gene ID" value="VAB18032_07120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07120"/>
    <dbReference type="eggNOG" id="COG1021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_11"/>
    <dbReference type="OMA" id="PMSPHDE"/>
    <dbReference type="OrthoDB" id="1015470at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="463"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="558" mass="59854" checksum="7BCA53FE0EE0ED2D" modified="2011-06-28" version="1">MAGSAGDRRTGGPVAVREGFTPWPAEFAARYREAGYWRGEVLGDLLRPWADWADEARDPGRTAVVTRHGRHTYGELDARADELAAGLFELGVRPGDGVVVQLPNTVEFLVTCVALFRLGALPVLALPAHRRAELTYLTQYVGAVALVTSDRTPGVDHRTVAQEVRDACPTLQHVLVVGDPGPFLAWSQVRAPARELPRPDPQDVAFFLLSGGTTGLPKLIPRTHDDYAFQLRATAEAMSFDHRHAYLAAVPVAHNAALGCPGVLGALRVGGRAVLAASPSPDEVFPLITQERVTLTTVMPAVLSLWVETADMFEVNLSDLVIEVGGAVLQPDLARAVRPALGATLTHWFGMAEGMLCFTRPGDGDEAAATTQGTPMCADDELLIVDEAGEPVAPGEVGELLARGPCVLRGYYAVPEHNRTVFTPDGFLRTGDLARFDAEGRLVISGRIKDVINRGGEKVMADEVEGHLLAHERVRAAAVVPFPDRRLGEKTCAVIVADDPAPSLVELRKLLRDRGLADYKLPDRLEVVEALPLTNVGKVDKRALAAAVLGDLTTAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFZ7</accession>
    <name>F4FFZ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic binding protein/laci transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_07265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731250.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07265"/>
    <dbReference type="EnsemblBacteria" id="AEB42577">
        <property type="protein sequence ID" value="AEB42577"/>
        <property type="gene ID" value="VAB18032_07265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07265"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_4_11"/>
    <dbReference type="OMA" id="AVWDQPA"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313012" evidence="2">
        <location>
            <begin position="26"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="85"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="38874" checksum="1BD09FA7DAF09A14" modified="2011-06-28" version="1">MKLSRRRGAALGALCALALMVGACSNETSGGNGGASSGPRTEPSLSFVGPGGETPTAADQLSLTPEERQKVKDGNYSAAFVWHEGSALTQAVESGVRKEFDELGIKVLASTSAEFDPARQANNVQTVLALKPDLIVTIAVDPTAAAAAFKPAVDAGVKLVVMTTPPKDFKAGEQIVGIVTVDLTAFGKANAELLGKALGGKGKVGYVYHDADFWFTNQRDKAFKDWLGYLYPDIEIVEETGFSDPARTEDIATAMLTRHADLNGVYVAWATAAEGVLAATRQQGRTDVKIVTNDLEANLAADLVKGGNVVGVIGNGSTRLGQNLGIVAAYGLLGKQAPELVVSAPMAATKENIAEAWRDDYGQEPPAEVLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG79</accession>
    <name>F4FG79_MICM1</name>
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        <submittedName>
            <fullName evidence="5">Cellulose-binding family ii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_13555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13555"/>
    <dbReference type="EnsemblBacteria" id="AEB43823">
        <property type="protein sequence ID" value="AEB43823"/>
        <property type="gene ID" value="VAB18032_13555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13555"/>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076862_0_0_11"/>
    <dbReference type="OMA" id="TPTFACP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307709" evidence="3">
        <location>
            <begin position="24"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="4">
        <location>
            <begin position="138"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="243" mass="25191" checksum="493FA95FED510E4D" modified="2011-06-28" version="1">MFGVVLATATLTLAAGLATPAVAQTAPVATPTPSPTPVCPPVLPINAMVTGTTANSVTITYSAFVVPPCGYDPPITFHLFGSHDDAIDWQDPIAQGTSGPERSGTVTIDGLTPGTEYWFRLSDAHGVRDRYVIGGPARTGLPAPCSATATVDSGWGSGFVATVTVRNTGADQLNGWRVRWSWPGGGSVQSIWNAVVETTSTEVTARHAEYNRVLAPGASTTFGLLAATSSVPAGFTLTCERWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG82</accession>
    <name>F4FG82_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_13570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13570"/>
    <dbReference type="EnsemblBacteria" id="AEB43826">
        <property type="protein sequence ID" value="AEB43826"/>
        <property type="gene ID" value="VAB18032_13570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13570"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133067_0_3_11"/>
    <dbReference type="OMA" id="ATTAMKY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="128" mass="13220" checksum="A1B1B72101EB2935" modified="2011-06-28" version="1">MIAAPDRQSDLRRLIRSGTECMVAYVFLLLAIAAEVTGTSLLKATEGFTRLWPTLGLAVSYLTAFALLAQAVKGIEVGVAYALWSGLGTAAIVAIGATVLGEPLTVTKVVGVGLIIAGVVLLNLRGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGB4</accession>
    <name>F4FGB4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733707.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19750"/>
    <dbReference type="EnsemblBacteria" id="AEB45052">
        <property type="protein sequence ID" value="AEB45052"/>
        <property type="gene ID" value="VAB18032_19750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19750"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_0_1_11"/>
    <dbReference type="OMA" id="HTHKIMS"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046278">
        <property type="term" value="P:3,4-dihydroxybenzoate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012794">
        <property type="entry name" value="PcaR_PcaU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02431">
        <property type="entry name" value="pcaR_pcaU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="72"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="28220" checksum="1C89D6C95A1BF535" modified="2011-06-28" version="1">MTDAARSGEFVQSLERGLAVIRAFDAEHPQLTLSEVARATGLTRAAARRFLLTLVELGYVHTDGRLFALRPRILDLGYAYLSSLSLPEVAQPHMEALVAQVHESCSVSVLDGDEVVYVARVPTKRIMTVGISVGTRFPAYATSMGRVLLAAQPADWLDDYLATAQLRPLTRRTITDPAKLRTTLNRIVGQGYAIVDQELEEGLRSLAAPIHGDDGAVVAAVNVSAHASRGTFDAIRRELLPPLLATARRIEEDLAAGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGT5</accession>
    <name>F4FGT5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02555"/>
    <dbReference type="EnsemblBacteria" id="AEB47595">
        <property type="protein sequence ID" value="AEB47595"/>
        <property type="gene ID" value="VAB18032_02555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02555"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079635_2_0_11"/>
    <dbReference type="OrthoDB" id="1974702at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="19420" checksum="C7BE67B269F89D1F" modified="2011-06-28" version="1">MLGPGGQPLASFGDRLLAYLIDTAIATAVLLVLFAPIFLIFMVGLLANLPETNPDGTLADPTPADVITEILLPMLLLQVALFAVMFAFYWLYHVEYLKRTGQTIGKKVMNLRVVPLDPTATLDRRMAGKRYLVEFVGGSLVPGGSYLDGLWQLWDKPWQQCLHDKFAGTVVVKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGV3</accession>
    <name>F4FGV3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47613">
        <property type="protein sequence ID" value="AEB47613"/>
        <property type="gene ID" value="VAB18032_02645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02645"/>
    <dbReference type="HOGENOM" id="CLU_2866574_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="6063" checksum="7689643CE9F87B52" modified="2011-06-28" version="1">MSGDEVGSGEGEPSGDGEPVGEGEPVGDGLAVGDGLVAARTVVSTTSRASGEVTVTVTGLCVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH88</accession>
    <name>F4FH88_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732533.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13770"/>
    <dbReference type="EnsemblBacteria" id="AEB43866">
        <property type="protein sequence ID" value="AEB43866"/>
        <property type="gene ID" value="VAB18032_13770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13770"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_11"/>
    <dbReference type="OMA" id="EHAAWWA"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="169" mass="19560" checksum="77E5245972BC65CD" modified="2011-06-28" version="1">MLRDATEEDVNLMLSWRNQEINRLASKTHHVISADEHARWWAAARTDPTRRVLIYLRDGLPCGVVNFFDLRFDPPRTGSWGFYLDADALAERGETLPAWIDVMRAAVDHAFDVLNLDRLDGEVLAHNTAVRQMNRRFRFVEGTGRIEIHDGREITVIPISLDRAARRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH90</accession>
    <name>F4FH90_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732535.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13780"/>
    <dbReference type="EnsemblBacteria" id="AEB43868">
        <property type="protein sequence ID" value="AEB43868"/>
        <property type="gene ID" value="VAB18032_13780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13780"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_13_11"/>
    <dbReference type="OMA" id="EARITHI"/>
    <dbReference type="OrthoDB" id="1015470at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="101"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="339"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="414" mass="44423" checksum="40BDE9418C95F813" modified="2011-06-28" version="1">MSVDTARPAAPLPAGLDNRVVVDGTALSWRGLPELRLPAPVALLAHRARYALAAARHHAVHGTELLITTASRADSVLRTELSEAGFTVTDTGGADLTPSRPRAGEAGRLWLLTSGTTGRPKRVGHTLESLTTVRGRQPDRTWLCPYAPGSYAWWQVVTLSLTQPGQHLVVVEPEQLDDWPALAATHGVDAASGTPTFWRRALHRDPAALARVPLRQLTLGGEPVDQAILDRLREVFPTTRISWIYASSEVGAAIVVHDGRAGFPVEWLDRPAPGRPTLGVRDGELVVTSPYHGVGLAGPIRTGDRVQVVDGRVLITGRLDSDEINVGGSKVSAGAVRDVLTAHPQVAWARVGARRAPLLGHLVVAEVVPTATVGPPDEAALVRWCADRLPEYAVPRRIRLLPEIPVKETLKSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHD6</accession>
    <name>F4FHD6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20030"/>
    <dbReference type="EnsemblBacteria" id="AEB45108">
        <property type="protein sequence ID" value="AEB45108"/>
        <property type="gene ID" value="VAB18032_20030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20030"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_8_11"/>
    <dbReference type="OMA" id="SIARHCS"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="189"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="388" mass="41070" checksum="1469094F1AF3EC94" modified="2011-06-28" version="1">MVDVGSAPHAASATTGVAVRTAQTLVFLLSIAYLSIPASRVITTQPVPNAGLALLALTGVALLQFRHTWHGLRGEPPVTWSWTLLLQAILSYAPAPLAGDAWLGVPSFLAASLLITLRSPLSYVAYLAVVLAEIPFALLVHEEPSDIAYATLGVALTGAVVFGFVKMATLVWEVHRLRATLAHRAVDVERLRFARDLHDVLGHQLCAIALKGELAAAVLHSRPESAEREINEVVGLAREAHRDIREVVAGYRSVSLAGEMTGVTSVLTSAGIECEVDTVPLDTLPSDAATPLAFALREGATNVLRHSIARHCSITLRPQDDGLVLRIVNDGVPPGPPHPAGNGLEGLRERLLELNGRLHAGPVGGGSFELVVFVPSLATKAAMVEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHL8</accession>
    <name>F4FHL8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase, NADH/nadph, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_26551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735038.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26551"/>
    <dbReference type="EnsemblBacteria" id="AEB46387">
        <property type="protein sequence ID" value="AEB46387"/>
        <property type="gene ID" value="VAB18032_26551"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26551"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_1_11"/>
    <dbReference type="OMA" id="DRANMPG"/>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="148"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="502" mass="53095" checksum="E456AF61082F67A7" modified="2011-06-28" version="1">MPDPNGFLRYPRRVPARRPVPVRISDWREVYPPAGEELIREQAARCMDCGIPFCHSDTAGCPLANRIPDWNDLVRTGNWDAAVESLHATNNFPEFTGRLCPAPCEAACVLGIAGGDPVTIKQVEVEIADAAVARGLTPRAVPPPTGRSVAVVGSGPAGLAAAQQLARAGHAVTVYERDDAIGGLLRYGIPDFKLEKRHIDTRLAQLTAEGVQFRTGVNVGVDITAEQLREQHDAVLLACGALQGRETDTPGRQLRGVHQAMAHLVAANRVVAAAGEGRPALATLADGTPIDAAGKHVVIIGGGDTAADCLGVAHRQGAAGVHQLDLYPQPPRARDEARDPWPTWPWILREYAAHEEGGERVFAVAVQEFVDDGTGAVRAVRIAEVTVEKRDGRRIVTAVPGTERELPADLVLLAIGFEGTEEQPLLAQFGVARNARGAIDSRADWQTGSDGVFVAGDMHRGASLIVWAIAEGRAAAAAIHTYLGGVGALPAPVHAGSRPLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHP6</accession>
    <name>F4FHP6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="6" type="ordered locus">VAB18032_26711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735066.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26711"/>
    <dbReference type="EnsemblBacteria" id="AEB46415">
        <property type="protein sequence ID" value="AEB46415"/>
        <property type="gene ID" value="VAB18032_26711"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26711"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_11"/>
    <dbReference type="OMA" id="IWLNANE"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="28"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="371" mass="39516" checksum="C956551AD27B7376" modified="2011-06-28" version="1">MTRLEDLPIRDDLRGRSPYGAPQLDVPVRLNTNENSYPVPDEVVEAIGKAVAAELRDLNRYPDRDALALRADLAAYLGHGLTAEGVWAANGSNEIQQQLLQAFGGPGRVALGFVPAYSMHPLLALGTGTRWVPAHRGVDFGLTVGEAVAQVREHRPDVVFLCSPNNPTGTALDPAVISAVLDVAPGMVVVDEAYAEFARPGTVSALAVLPGHPRLVVTRTMSKAFGFAGGRLGYLAADPAVVDAVQLVRLPYHLSALTQAAARAALAHRDALLGTVAAIMRQRDRIVTELRRRGLRVADSDANFVLYAVDGDQTLAWQAMLDHGVLVRDVGLPGWLRVTAGTPAETDAFLAAIDQIQRAGLPAPQPRPKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI19</accession>
    <name>F4FI19_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713105.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47983">
        <property type="protein sequence ID" value="AEB47983"/>
        <property type="gene ID" value="VAB18032_30099"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30099"/>
    <dbReference type="eggNOG" id="ENOG50322DW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2302659_0_0_11"/>
    <dbReference type="OMA" id="WGAITPA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="100" mass="9628" checksum="63FD5180F6A13035" modified="2011-06-28" version="1">MGSRRWVVIGAGWVVAAGLVLAAVVFGLQGVEVASWLAGAASFVVAVAALVLAPSGGPAATPMPPAAVTPPAAGPGSITVQGDLTGIASTGDNATNTQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1H1</accession>
    <name>F4F1H1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733854.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20500"/>
    <dbReference type="EnsemblBacteria" id="AEB45200">
        <property type="protein sequence ID" value="AEB45200"/>
        <property type="gene ID" value="VAB18032_20500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20500"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_35_0_11"/>
    <dbReference type="OMA" id="GKHDPFF"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="32430" checksum="1B267384ADC029AE" modified="2011-06-28" version="1">MVEVRHRYATVRGHRIFYREAGPHGAPTLLLLHGFPTSSRMFRQLIPRLADRFHVIAPDHLGFGHSDTPPADTFTYTFDALADLTEALLTDLGITRYAIYVQDYGAPVGWRLALRTPAAVTAVISQNGNAYDDGFVPQFWAPVWAYAKNPGPDTEPAVREALSLDAIRWQYLHGVDRPELVDPDTWTSDHRDISRPGNDLAQLALFRDYATNPPLYPRLHAYFRQSQVPLLAVWGAEDLIFGPDGARAFTRDLPAAEIRLVPGGGHFLLESHLDTAAAHIRDFLTRTVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1L9</accession>
    <name>F4F1L9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20740"/>
    <dbReference type="EnsemblBacteria" id="AEB45248">
        <property type="protein sequence ID" value="AEB45248"/>
        <property type="gene ID" value="VAB18032_20740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20740"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_2_0_11"/>
    <dbReference type="OMA" id="YAYGFIM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="25696" checksum="6ACCA97242DA169A" modified="2011-06-28" version="1">MELDPSTVAILLTAAAMAGWVDAVVGGGGLLLLPALLVAVPGMPPAMALGTNKLAAIAGTSTAALTFARRTKIDWAVAGPAAALAVVCAGVGAALAGAVPPSAYRPVVLVVLLVVALFVVLRPRLGVAAAPHRRTRARVVVAVLVAGVGIAAYDGLIGPGTGTFLVLAFTALVGADFLHGSAMAKVVNAGTNAGALAVFAVTGNVWWLLGAAMAVCNIVGAMAGARMALRRGAGFVRVVLLVVVLALVAKLGYDQWLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1N9</accession>
    <name>F4F1N9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_26956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735115.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26956"/>
    <dbReference type="EnsemblBacteria" id="AEB46464">
        <property type="protein sequence ID" value="AEB46464"/>
        <property type="gene ID" value="VAB18032_26956"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26956"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_11"/>
    <dbReference type="OMA" id="FTMRWVF"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="495" mass="52705" checksum="6F748F29E2298D56" modified="2011-06-28" version="1">MARIVVVGAGVGGLATAARLAVTGHQVTVLEQADTVGGKLGRHTRDTEAGSFHFDTGPSLITLPEVFHELFEATGAKLDEYLDLVPLDPIVRHVFDDGAAVLDSCADPAEFTARIGAALGDRAAADWQRLWRRAARVWRASEHDILRRRVDSPRDLARLAWRLGDLAAIRPGQSLRGLGRSHLSDPRLRMLLDRYATYTGADPRRAPAALVAVPYAELTFGGWYLRGGLGTLADALLSRCLDLGVVVRTGTTVTRIDATGGRVHGVRVADQRAPIPADVVVANVDALTVYRDLLPDARRLAGLTDRSLAGFVLLLGVRGESGLAHHNVFFPRDYDAEFDAVFGDPGRGVRARPAADPTIFVTVADDPAVRPDGHEAWFVLVNAARQGTAPGAVDWRRPGLAQAYADRILDVLAERGVDVRDRLVFRDIRTPADLATATGAPGGTIYGTAGGLLRPANRGPARGLWLVGGSSHPGGGLPMVTLSAQIVADAVGPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F236</accession>
    <name>F4F236_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736415.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03495"/>
    <dbReference type="EnsemblBacteria" id="AEB47783">
        <property type="protein sequence ID" value="AEB47783"/>
        <property type="gene ID" value="VAB18032_03495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03495"/>
    <dbReference type="eggNOG" id="COG4842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151185_3_0_11"/>
    <dbReference type="OMA" id="PLQQTWT"/>
    <dbReference type="OrthoDB" id="1930308at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="95" mass="10467" checksum="58529EB478B0B492" modified="2011-06-28" version="1">MEIRYNFAGLNAAADSCGSSVRNMTSELEGLKSGIAPLLATWDGDAREAYFQRQREWESAANDLRDLLGRIERALRESAGKMQAREAANRAKFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2B2</accession>
    <name>F4F2B2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08415"/>
    <dbReference type="EnsemblBacteria" id="AEB42801">
        <property type="protein sequence ID" value="AEB42801"/>
        <property type="gene ID" value="VAB18032_08415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08415"/>
    <dbReference type="HOGENOM" id="CLU_3013042_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="56" mass="4942" checksum="7CDD6EC2DC6D4E7F" modified="2011-06-28" version="1">MPDTGGAGGALLGGCGADHEPPGSAGGGGDQVPSCGAPSVDPAAGGGAHGSLGWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2L7</accession>
    <name>F4F2L7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formate dehydrogenase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20910"/>
    <dbReference type="EnsemblBacteria" id="AEB45282">
        <property type="protein sequence ID" value="AEB45282"/>
        <property type="gene ID" value="VAB18032_20910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20910"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061371_1_0_11"/>
    <dbReference type="OMA" id="AGSNEWK"/>
    <dbReference type="OrthoDB" id="1806297at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="189" mass="20613" checksum="621B47C69339594B" modified="2011-06-28" version="1">MGLRDVLLGWPVYRQLTGTDPLGRGAAAQSARSAGLTARTEDADRVARSVCPYCAVGCGQRVFVSDNRVTQIEGDPDSPISRGRLCPKGSASKSLVTSPLRQTTVRYRRPYATEWEDLDLDTALDMIADRILAARAETWEDVDAEGRPLNRTLGISSLGGATLDNEENYLIKKLFTAMGALQIENQARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F311</accession>
    <name>F4F311_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736422.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03530"/>
    <dbReference type="EnsemblBacteria" id="AEB47790">
        <property type="protein sequence ID" value="AEB47790"/>
        <property type="gene ID" value="VAB18032_03530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03530"/>
    <dbReference type="eggNOG" id="ENOG5034AYS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517673_0_0_11"/>
    <dbReference type="OMA" id="IEQMWEY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="576" mass="59225" checksum="845F7765EC5E5B11" modified="2011-06-28" version="1">MTDDYYGYRPISYPAYGGMRDDYAADRAAQATPYQPTDWDGVNIEQMWEYVRKESNERTVALAEMWRRAASLLESTRDNLKRHADALGAKWNSPASRVFMSKVGATLHSLDEWKNVASSNATGLDQLASKISTAQREMTQLWLEYKAEQQHQQDVYEKDKAKITFSDIFGDKHKSYEEVQKEFHQRAKNITKPLADMYIDVYISNISRGGKFKGPTEAALFDGKTVPGGPGRTGGPTRPGAVPPGARGPRPDRPEMPNRLEQPNQPEVGARPPQPSAPTLPDGVDLAGGTATVAPPGPAPTPPPVTTAPNAPGTPGPPLPPVVPPGQRPGGGGPGTPNPGGRPNAPRATLPGSGGAPGPGGGRGPAPNRPTLPGAGGGSGAPGSGRRGPAPNRPTLPGNTGAPGRPGAGALRPKPSAGPPPSSPRLPGSTAPSGQRGAASGRPAAPPPSLGGQRGATPGTPPKAGGPLGSRPATPPGGRASGPGAKGSAGRPDLSGRTGAARPAPATGPGPSLSGRRGAPAAPGARKGTQHDLEQETWEYGDGDDELWVTESSAVGVVEAPAEHRPREQGRTLGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F312</accession>
    <name>F4F312_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase S8/S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">VAB18032_03535</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736423.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03535"/>
    <dbReference type="MEROPS" id="S08.121"/>
    <dbReference type="EnsemblBacteria" id="AEB47791">
        <property type="protein sequence ID" value="AEB47791"/>
        <property type="gene ID" value="VAB18032_03535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03535"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_13_3_11"/>
    <dbReference type="OMA" id="FSTRRWY"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309038" evidence="13">
        <location>
            <begin position="32"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="14">
        <location>
            <begin position="55"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="378"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB47791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="417" mass="43504" checksum="6F0CDA8BF58FC9D0" modified="2011-06-28" version="1">MRVLTRPTAVLALSTVSALAVLTLPAAPALADSTRDDSWHVKALELPELHKITQGEGVVVAVVDTGVDAKHQDLKGNVLPGADLYDDDTKGGVDRVGHGTGMASLIAGHGHGPGGGNGVLGVAPKAKILPVTIKSERSPLIAPTALAAGINWAIDNGADIINVSLGSSFNEELDRAVARAYQRNVVVVAAVGNREDMIISNPARHPATIAVNGTDRKGVISKEAALPAEEVSIAAPGEDIVQAAPGDKYVTSLGSSSSAALVSGAMALIKAKYPDLNAYELFERLLETARDAGDPGRDLDYGWGVLDLRTALTGEPDGRASPRASGPPSAQLEPWQVNPREREDGILVFVWAAILVVLVGGGIATVWMLRNRSQRRQAELVDDDEPVPVGTAFGDGPPNDPGQPAEVTDDVWRRPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F317</accession>
    <name>F4F317_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736428.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03560"/>
    <dbReference type="EnsemblBacteria" id="AEB47796">
        <property type="protein sequence ID" value="AEB47796"/>
        <property type="gene ID" value="VAB18032_03560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03560"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008749_0_1_11"/>
    <dbReference type="OMA" id="IQVNEWR"/>
    <dbReference type="OrthoDB" id="464195at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="450"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="559" mass="59064" checksum="1480F9AA4619E6B2" modified="2011-06-28" version="1">MTRTLLVAPDQPGAYPSIGEALAVAGDDTVVSVSPGTYYEALFVNDRAVTVIAAQGAGTVTIDASSGAYPTVSCNSGRLELRDLVLKAGDAPVVVGDRATLTMSGCELSAGFGAAIQVAGRSEFTLTRCRVTGGRYGLVVEDSDGTVEGCEFADLSEDGIIVRIGAAPTIRTSTVTRCGNRGIYIYQYGRPTIEACDISQTGHAGVAVVHQSAPVLRRCRIRDTRGPAISFARGCQGTVEECTTENTAQPAIEVAEGAAPTIVEGTASRKAAYGADAARAATPQDTARVDKLLAELEQMVGLESVKEEVRALIDEIQVNEWRRSAGLPVGAVSHHLIFAGAPGTGKTTVARIYGDLLAALGALPGGAFREVSRRDLVGQYIGHTAEKTAAAFEQARGGVLFVDEAYTLSRSSGSGGDFGQEAIDTLVKLMEDHRDEVAVIAAGYTGEMLQFLDANPGLASRFAKTIEFGNYSPDQLVVIVERMAGGDEYLLADGVTDVLREHFGTIERDQNFGNAREARKLFEGVRKAQAQRLRQSGQRPSLDELRTVTVADVRTAIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3D6</accession>
    <name>F4F3D6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome bd ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_08710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731531.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08710"/>
    <dbReference type="EnsemblBacteria" id="AEB42860">
        <property type="protein sequence ID" value="AEB42860"/>
        <property type="gene ID" value="VAB18032_08710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08710"/>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_1_11"/>
    <dbReference type="OMA" id="IRAMFSM"/>
    <dbReference type="OrthoDB" id="271551at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB42860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="418" mass="45441" checksum="3FC2F7D3E076781D" modified="2011-06-28" version="1">MDALLLARLQFAATASVHFLFVAVTLGLVTLLVGLQTAWLITGNPRFERLTRFWGQLYVINYVLGIATGIVMEFQFGLNWSGLSRYVGNVFGAPLAIETLVAFFLESTFLGMWIFGWHRLRRGVHLALLYGVALTAYASAFWILVANSWLQNPVGYEVRDGVAHLTDFSALLTNPALWMAFGHVVSAALLTGGMLMAAVSAWHLTRGTGDFDLFRTSLRIGVVTATLAIGLVQSFGFAQFGAVGAIQPTKFNGTGPDAEALVADWTARFGPGDYLPPVLANAGLGFMILIGFGLGLLWLILPLLWRDWIIRLRFPLWLLMIALPLPFVAVILGWIAREVGRQPWVAYGLLRVDQAVSPIDPWLMATSLIGFTLLLGGLAVTNWVLLARHAAAGAADPALGRPPTQPPADDSRTEPAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3E5</accession>
    <name>F4F3E5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_08755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08755"/>
    <dbReference type="EnsemblBacteria" id="AEB42869">
        <property type="protein sequence ID" value="AEB42869"/>
        <property type="gene ID" value="VAB18032_08755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08755"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OMA" id="HFISPER"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009654">
        <property type="term" value="C:photosystem II oxygen evolving complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002683">
        <property type="entry name" value="PsbP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01789">
        <property type="entry name" value="PsbP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="SSF55724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="659" mass="69135" checksum="8AF7E184FC805B55" modified="2011-06-28" version="1">MGTVWRATDTLLRRDVAVKEVILPPGLAPSDRDAMYERTLREARAAAAIAHPAVVQVYDVVTEAGRPWIVMELLDARSLADMVIEDGPIAQRVVAKIGIALLGALEVAHAIGVLHRDVKPANVLICSDGRCVLTDFGVARMPTDVQLTTPGMVLGSPHFISPERAMGQEFGPPSDLFSLGVTLYTAVEGRPPFDRGDPIETMHAVVEDPPAPPQRSGPLTRVLMGLLEKDPARRLDVHTARAMLRELLAGPLSSNAAAVNSMTDPYSVMQVPQPAPISAPAAPAKAKPSGQIGGSAMLAPGESLTDRLAALRRGERPGQATPVSPAAMEETSADALARPGQHGAMSPPPVGRTYGTAADATQHIGGADATQRFGGADATQRIGGADATQRIGGADATQRVGPAAFGYGGGQPEATQHIGGDYGGQWPAAPSQPYGARPTPTGGSPLDKAKAAGSQLVDTVKGWPRKMQLAAAGGLALILLIGIVALSGGDDSSPTTPVADPSSSADAGPGIEMQEYSGRGVQVLVPKGWKKAAPSGAVYVDYTDPEDSGRRVRILNEPWRGDSARWAEVAANGLKSKSTSCAKPYNQISMEQKELAGKPSAEFEYTCGQGEAMRHGVWHGVAHDGRMYSFYLTANDSRFEESKPIYEEMVKSFQLTNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3N9</accession>
    <name>F4F3N9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">pheS</name>
        <name evidence="15" type="ordered locus">VAB18032_15175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732812.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15175"/>
    <dbReference type="EnsemblBacteria" id="AEB44147">
        <property type="protein sequence ID" value="AEB44147"/>
        <property type="gene ID" value="VAB18032_15175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15175"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_0_11"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="129"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB44147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="39390" checksum="956AAFCF06FA3B9F" modified="2011-06-28" version="1">MTYRNDPYDPKQVALLDPAALAEAVTEAEKAFAAAGDPDALAAVRPAHLGDRAPVSLARREIGALPPAAKADAGKRVNEARRSIEQAYAARSEVLDREQAQRVLVAERVDVTLPYDRRPRGSRHPVSVLMEQISDLFIGMGYEVAEGPEVELEWTNFDALNIPVDHPARGLMDTFHIAPEQSGLVLRTHTSPVQARTMLTRQPPIYVVVPGRVYRTDELDATHSPVFHQVEGLVVDKGITMAHLRGTLDHFARAMFGEGAKTRFRPHYFPFTEPSAEFDVWFPEHRKGPQWVEWGGCGMVNPRVLRACGIDPEVYSGFAFGMGIDRTVMFRHGVGDMRDMVEGDVRFTRAFGHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3S2</accession>
    <name>F4F3S2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21365"/>
    <dbReference type="EnsemblBacteria" id="AEB45373">
        <property type="protein sequence ID" value="AEB45373"/>
        <property type="gene ID" value="VAB18032_21365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21365"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140396_0_0_11"/>
    <dbReference type="OMA" id="GVSCIAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="17566" checksum="55B105E30FCAD9EA" modified="2011-06-28" version="1">MVGEHGPLRVGVAGHIHLTPGSVRPIADALRAELHRLSDRPVHGVTCLADGTDQIFARVVLATGGTYEVILPAADYRDTITAARRAEFDELLARASTVIHTGHQHSGTAAYLAANQELLSRVQCLVAVWDGSPGCHAAATDRTVDAARQRGIPTTVLWPAQARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4B0</accession>
    <name>F4F4B0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04205"/>
    <dbReference type="EnsemblBacteria" id="AEB47923">
        <property type="protein sequence ID" value="AEB47923"/>
        <property type="gene ID" value="VAB18032_04205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04205"/>
    <dbReference type="eggNOG" id="ENOG5030HTG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087581_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="261" mass="27202" checksum="6112D5B2A84A7122" modified="2011-06-28" version="1">MANYGPPGGGPQPWHEPRPGEVQGQVYGSGQTYEPGQAYDSGHVYGSGQMYGSGQGGYEAGQSYCAGQSYGAGQGYEAGQGYGGYPQGGRAFQDDAGVAAYAGQPTPPPERRRGRTPMIAALVSVLVLAAGGVAFYLLGQDESTPTAVAAPTQDPVPTADPTGDEEDPGAGVPTANSSTDPRFVEQGQCVRNDAPTGGKPKLLITDCGPSAYEVLQRFDGKTSGEKDAEAKCAKVDGYTNWYFYDSELDSLDFVLCLKQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4K1</accession>
    <name>F4F4K1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731630.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09205"/>
    <dbReference type="EnsemblBacteria" id="AEB42959">
        <property type="protein sequence ID" value="AEB42959"/>
        <property type="gene ID" value="VAB18032_09205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09205"/>
    <dbReference type="eggNOG" id="ENOG5031QZB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151362_0_0_11"/>
    <dbReference type="OMA" id="PWPCAEA"/>
    <dbReference type="OrthoDB" id="2020318at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12510" checksum="8DD43AE347ADB7BC" modified="2011-06-28" version="1">MITTQLVPGRGPHPVRPYASGVNAPHTPLRPMWCCRVDGQPWPCAEARLLLRAEFDRNAVGLTIYLAGLMYEAMRDLYHLNPHDGPEPTALFDRFVGWAGRGRNARQDGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4S9</accession>
    <name>F4F4S9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732885.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15545"/>
    <dbReference type="EnsemblBacteria" id="AEB44221">
        <property type="protein sequence ID" value="AEB44221"/>
        <property type="gene ID" value="VAB18032_15545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15545"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119508_0_0_11"/>
    <dbReference type="OMA" id="TIYNADM"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="189" mass="21283" checksum="CF770AD1748AA7F1" modified="2011-06-28" version="1">MTSGRPVLVVTDMQNGFVREQSAHIVPVVVDLVHRWQLAGGDTLFTRYLNYPGSPFERFFGWQRLQSSPDIDFVPELRPYVDQGVTLDKRIYSPFTSEGVALFRQRRWEEYYFCGIATESCVLKGAVDAFEHDFTPWLIADASASHAGTEAHEAGLLVARRFIGPRQVIRLADIPLALIDLSPQSPPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4V6</accession>
    <name>F4F4V6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734098.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21725"/>
    <dbReference type="EnsemblBacteria" id="AEB45445">
        <property type="protein sequence ID" value="AEB45445"/>
        <property type="gene ID" value="VAB18032_21725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21725"/>
    <dbReference type="eggNOG" id="ENOG502Z7I8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465252_0_0_11"/>
    <dbReference type="OMA" id="RDEMANM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="623" mass="66270" checksum="4A20C30B2C131A33" modified="2011-06-28" version="1">MSMQNGWARLEPTVRERTGEEGLQAGIADPLWLLTRQWQLGEFAATDAGTPVWARLRGTVTGLTRLRPGPPPTGPGATGLRYDVGTVPLEALVESEPAVVGTEGTRDLALRAGGYFLTLLAEEWEGTMLPAESQAGYVAGLLATHPVPTEGLPAGDRLLAARVPDGVALFAALDSGLRPPDGGRPTLPAQPPLTSAAARPVRAAALRFLAWYDGVTGRALPELPTWSPQRLEYQVSLAAPAVGGEPEFVLTTDEYASGSLDWYAFDHVPGGSLGAVASDPGGTGRPFLASGIPTPVTFRGMPAARWWEFENAAVDFGSVRAAGDSIATMLLVEYATVYSNDFFLFPVAMEVGSVCRVSSLVVHDTFGQRMLVPPTRSAVRGAEFAIYEHSAYDPLSGGTGPLSLRDSTFTLLPTLDDSHDSAPVEEVWLLRDESANQVWAVEATACGPDGRPVDRAERHAAGHVAGGTVTPSADPDLPLRYRLRTDTPGHWFPLDPSPQAAQMLDLGAVPPLDGTPAPLPWGRLLAELRQHRLHREEVTRAGTHLTRAWQYARWTDGRQHLWLGRRTRVGRGGGASGRYHDVLWPGPVTASGLPGAPEPGGPPAAPRPAGPGLPPNRPPAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4X4</accession>
    <name>F4F4X4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class v</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_21815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21815"/>
    <dbReference type="EnsemblBacteria" id="AEB45463">
        <property type="protein sequence ID" value="AEB45463"/>
        <property type="gene ID" value="VAB18032_21815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21815"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_11"/>
    <dbReference type="OMA" id="VASCFDY"/>
    <dbReference type="OrthoDB" id="1474443at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="72"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="389" mass="42153" checksum="9B70AC6889192B8C" modified="2011-06-28" version="1">MRVSQPEQSPRCLDAAAHAALRAEFPLLASCVYLNSNSTGVVPRGVETVLHDYWETLRTWRDDVWQDWHIGLDRYADSVATLLGAPPGSVLTDANLSTFLARVASCFDYRPPRNRVVITDLDYPTVPFIFRAYGRYGAQLDVVGTGGPHLDQDALEARIDERTLLVCVPHASFTSGATVDLSRLVTRAHQVGALVVVDAFQTVGVVPLDVTALGVDVVLGGSHKWLCGAGTAFLYVRPDLVPLLTPAATGWQAGDRALTFRPSPGWAPGIRRFAGGTPYPLTSLISQVGLDLLLDVGADAIRRHSLALTGRLLDRADAAGITVVSPTDSARRGGVVCLDVPDGEAVKQRLAARDVICSWRGYLRVGPHVYNTLDEIDLFMDALEEELHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F551</accession>
    <name>F4F551_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28311"/>
    <dbReference type="EnsemblBacteria" id="AEB46733">
        <property type="protein sequence ID" value="AEB46733"/>
        <property type="gene ID" value="VAB18032_28311"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28311"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076844_0_0_11"/>
    <dbReference type="OMA" id="RIEMNGV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="103"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="250" mass="26006" checksum="95913A470EFE8A81" modified="2011-06-28" version="1">MIAAAIALTVLAGCNNLSFRRLDFDTTEEARISTIRLLPGAGDVVIRADGEPDRIRIKRVVRYQGDEPGITYEIKGTELVLDTSCGRRCSVSYEVVAGEGVRVEGETGSGNIDLSWVGQVEVTVGSGDVRVVGAAGPVRVESGSGEIEVYDLTSTVVLRTGSGDITATRLRGEVDAQASSGNVTVELDAPASARAHASSGNVELRVPAGSYQIRSEAGSGSVDVSVPNDPTAALVLDVRTGSGDISLMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F565</accession>
    <name>F4F565_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_28381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28381"/>
    <dbReference type="EnsemblBacteria" id="AEB46747">
        <property type="protein sequence ID" value="AEB46747"/>
        <property type="gene ID" value="VAB18032_28381"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28381"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_1_0_11"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB46747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="409" mass="43031" checksum="9CF5F50A219E1DE5" modified="2011-06-28" version="1">MAMPGVLPAGEPVPTDGSLPASARASVGDQGFGVYVHVPFCASRCGYCDFNTYTAQELGGGASRDGYADTVLAELALAARVLGDRPPRRVETVFVGGGTPTLLPADDLARILDAIDRTWGLAADAEVTTEANPESVTPASLKELRAAGYTRISLGMQSVAPGVLAVLDRRHSAGRATAAALEARDAGFDHVNLDLIYGTPGEQPEDFAASLDQVVAAGADHVSAYALIVEDGTRLAARMRRGELPYPDDDVAADRYLAAEAALDAAGFSWYEVSNWARTPSGRCRHNLLYWTGGDWWGLGPGAHSHVGGVRWWNVKHPTAYAQRLAAGRSPGLAREVLTADEARMEEVMLRLRLADGLPLDVLDDAGRAAAARAVADGLLAAPAHAAGRGVLTLRGRLLADAVVRDLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F572</accession>
    <name>F4F572_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28416"/>
    <dbReference type="EnsemblBacteria" id="AEB46754">
        <property type="protein sequence ID" value="AEB46754"/>
        <property type="gene ID" value="VAB18032_28416"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28416"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077925_0_0_11"/>
    <dbReference type="OMA" id="WYAREAA"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="48"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="33814" checksum="E993BC14A7E47C2E" modified="2011-06-28" version="1">MSYHATAQRPGWAALPAAVRAALSARLGAPVVEARVATAGFTRGFAAVLRTADGGSAFVKAAAHAEQPHLVDWYAREAAILTRLPAGLPVPRLRWTLWEAGWYALCLDPVDGHTPRLPWDPAELDATLAGFVDIAAALAEPPADLAELGLPRLADLAREDILWWGEVAAGREPTPPLPAPVAGRLAELVALESKLPGYAAEATGLTHGDLRVDNILIGTDATAWFCDWTWLCHGPAWFDLAGLLITGYASGLDVDSRFATHPAAADAPADALDVTLAALAGYHLTAAASPPPTASAQLPAHQRWTGEQALAWLARRQAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5C7</accession>
    <name>F4F5C7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmH</name>
        <name evidence="6" type="ordered locus">VAB18032_04465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736606.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04465"/>
    <dbReference type="EnsemblBacteria" id="AEB47975">
        <property type="protein sequence ID" value="AEB47975"/>
        <property type="gene ID" value="VAB18032_04465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04465"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_1_11"/>
    <dbReference type="OrthoDB" id="2069770at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="45" mass="5312" checksum="96330D25B0BCCDFC" modified="2011-06-28" version="1">MSKRTYQPNNRRRAKTHGFRLRMRTRAGRAIISTRRAKGRARLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5E4</accession>
    <name>F4F5E4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_09290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731647.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09290"/>
    <dbReference type="EnsemblBacteria" id="AEB42976">
        <property type="protein sequence ID" value="AEB42976"/>
        <property type="gene ID" value="VAB18032_09290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09290"/>
    <dbReference type="eggNOG" id="COG3339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132031_0_0_11"/>
    <dbReference type="OMA" id="TERFLEW"/>
    <dbReference type="OrthoDB" id="2017850at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF1232" evidence="5">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="118" mass="12324" checksum="5CAB2F9E1D40CE26" modified="2011-06-28" version="1">MARTLKRGAAFVALGRALTAGARGGPSLGARIGALPRMIAATARGRYDGGLRLAMMTAATAYIVSPVDAVPELFLTVFGLIDDAVMVTWLAGAVLAETERFLEWEARTSTVVPGHVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5I6</accession>
    <name>F4F5I6_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09500"/>
    <dbReference type="EnsemblBacteria" id="AEB43018">
        <property type="protein sequence ID" value="AEB43018"/>
        <property type="gene ID" value="VAB18032_09500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09500"/>
    <dbReference type="eggNOG" id="COG3824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118049_2_0_11"/>
    <dbReference type="OMA" id="RTPMFGT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="13585" checksum="68CBBABE9B85F995" modified="2011-06-28" version="1">MPATVPLARTKAEIFDDLVLDTVETLERRFAKELAGVEFAVEDVPPELNVYDSDVLEDGEVPLARLLPGRPGRQEVPPRIVLYRRPLEFRAMDREDLADLVHDVIIEQVANLLGVDPDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5T7</accession>
    <name>F4F5T7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44300">
        <property type="protein sequence ID" value="AEB44300"/>
        <property type="gene ID" value="VAB18032_15950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15950"/>
    <dbReference type="HOGENOM" id="CLU_1969598_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="127" mass="13363" checksum="64A52E03608E5F53" modified="2011-06-28" version="1">MPALDPDAQAVSALLREAVKLVAAGHPAKAVIDARRAIEVADTVFGALNASNAAMKLITDIPPNDRTQEERFALLRHALFSLASPPAHGDPKAEQFTWSREAALVVISAVASLMAVRSDAGRTTGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F615</accession>
    <name>F4F615_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase BNR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22370"/>
    <dbReference type="EnsemblBacteria" id="AEB45574">
        <property type="protein sequence ID" value="AEB45574"/>
        <property type="gene ID" value="VAB18032_22370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22370"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004847_1_1_11"/>
    <dbReference type="OMA" id="RFNWQTP"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307438" evidence="1">
        <location>
            <begin position="25"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Sortilin-Vps10" evidence="2">
        <location>
            <begin position="170"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Sortilin-Vps10" evidence="2">
        <location>
            <begin position="554"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="777" mass="83470" checksum="4DE9BD92EB84CB9B" modified="2011-06-28" version="1">MVGLLATVALAASSSPPPAAPSLATNLPTGPMEVPDEWMTAQRLSDGSTSLSVTKYANARSQANQLAVRTKNSYRKLGDQKWDFFGPLNIGGRVVDIAIDPQVPDQLFIAAASGGVWKSSDAGNVFTPAWPDDWAQPIGALAMTSDGVLFAGSGEAQPGGGSITFGGDGIYRSTDRGESWKRVGLTDSHAIGRLAIDPTNEDRIFAAASGNLFVPGGERGVYLSENGGDSWRQVLAPPNPRTGATEVIIDPSNPDRVYAAMWDHLREPHQRTYGGPGSSLWRSDDGGETWQRMTNGLPTDADQGRWGLAVAPNNPQRLYAYVGTAIGPFRAFYRSDNGGDTWTQMPISTNQASQSTFSWWFGKIWVDPANADHLFLMGVNLMRSTNGAQSFSSVGGVHADQHVMRWDSKVPGRVYLGNDGGLYRSEENGARAWVKATDERYTQFYTVDVAETDPTLKVAGAQDNGCNRGYNGRLGPWNAIGCGDGLQTIIHPENPNIVFGCSQYGACYRSENAGGTPRQNIGTGQTTSQRRNWLTPLLFDPNDPNVMYYAGNIVNRSTDNGRTWTPISPDLTNGGPNDPSGYPWGTITTVAVAPSDSNTLYVGTDEGKVWWTRDLGATWNEVDQAKLPGTWVTRIAVNPKDANIAYATFSAFRSGSNRAHVLMTRDGGQTWINIGQGLPDAPVNSIVPTADGLLVVGTDVGVFLSAWNGGEWAALGKNLPQAPVMYLRYHEPSRQLTAATFGRGIYDVTVPRCPASSTKLPLKNPGVGVVGVLNSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F621</accession>
    <name>F4F621_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily mfs_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22400"/>
    <dbReference type="EnsemblBacteria" id="AEB45580">
        <property type="protein sequence ID" value="AEB45580"/>
        <property type="gene ID" value="VAB18032_22400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22400"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_15_5_11"/>
    <dbReference type="OMA" id="MLAMWAP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="403" mass="40239" checksum="0A432593BAD701D2" modified="2011-06-28" version="1">MVRRNAALFVTISVLSGFGGSAMALVAGIWILDLTGSSGLAALAGLCVYAPTLAGPWLGALVDRLPRRGLLIATNLTLAAVLPTLLAVHGPAQLWLLFTVCAVYGIAYVVIDAGESAILPAALSPAELGHVNGWRSSAQEGVKLVAPLAGAGLYAWRGGHLVALLAAVLPLLVAVGYAALRLSATEATTARRRGAARAGLAVLTGSASIRRTVGLAATAIGMQALTTAAGYEIVTVELGLPATFLGVLLSAQGAGSVAGGLVVGRLITRFSPTTVAVVGTALFAASCLGRCVPWWPAVLAASVVAGVGLPWTLVAAVTAVQTHSPDDLLGRASATANTIMFGPIALATPLGAAAVLLGARPPLVLAAAVCLTAAVAIGRRSRPGRPRSGRAGTRSPQPAPTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6F7</accession>
    <name>F4F6F7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09925"/>
    <dbReference type="EnsemblBacteria" id="AEB43103">
        <property type="protein sequence ID" value="AEB43103"/>
        <property type="gene ID" value="VAB18032_09925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09925"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_13_2_11"/>
    <dbReference type="OMA" id="NVYERWE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="85" mass="9405" checksum="414994809325DC6F" modified="2011-06-28" version="1">MDPAERDDYLATCAEIVRQARSAPGCVDFAISADLVEPGRINVYERWESDEQLLDFRGSGPEPEQQVALVGAEVHKFRISAVESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6X1</accession>
    <name>F4F6X1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45646">
        <property type="protein sequence ID" value="AEB45646"/>
        <property type="gene ID" value="VAB18032_22730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22730"/>
    <dbReference type="HOGENOM" id="CLU_3367963_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="35" mass="3684" checksum="151410ABED5D2EA6" modified="2011-06-28" version="1">MAVVACSSAVTWECTTTYMPRKGMPASFAAVSMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6X8</accession>
    <name>F4F6X8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734305.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22765"/>
    <dbReference type="EnsemblBacteria" id="AEB45653">
        <property type="protein sequence ID" value="AEB45653"/>
        <property type="gene ID" value="VAB18032_22765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22765"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_3_1_11"/>
    <dbReference type="OMA" id="MFERDKD"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="150"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="348" mass="38005" checksum="9EF6F077627304B4" modified="2011-06-28" version="1">MSRSRTERLVNLVICLLSTRRFLTAAQIAATVPGYEHDPDDAREHEAFQRKFERDKAELRELGVPLETGTASAFDTEPGYRIARREYALPEIPLKPDEAAAVGIAARLWQHAGLAAAASSGLAKLRAAGVDVDPHATLGLEPMVNVDPAFAPLTAAARDRREVRFDYRVPDRDAPDHRRLQPWGVVCWRGRWYVVGHDLDRDATRCFRLSRVVGQVRATGTPGAYQPPVGVDLISHVARWSGPTEHAGRATVLVAPGRAAGLRRVAVEATLGPEADRLVLPYTDVDLIAGHLVGYGPEVRVLDPPEVRDAVIQRLKEIAAHHDLPPAVPVRARSELASPAVANGRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F771</accession>
    <name>F4F771_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10055"/>
    <dbReference type="EnsemblBacteria" id="AEB43129">
        <property type="protein sequence ID" value="AEB43129"/>
        <property type="gene ID" value="VAB18032_10055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10055"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_11"/>
    <dbReference type="OMA" id="IAVYRHQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="21735" checksum="5946A7B08157E30D" modified="2011-06-28" version="1">MFRLLGHRDGGHRTVPARNTDSPPPRKRADAERNKQALLEAAAAAFVDAGVNAPVRDIAARAGVGVGTIYRHFPARADLIVAVYRHQVQACAEAAPTLLATGPTPHDALAAWVDLFVDFLITKHGLAEAMRSDAAAFEPLHAYFLEHLIPAVTLLLDAAVDAGQITPIEPFALLRGIGNLCIGADPRYDPRPLVAILIRGLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F797</accession>
    <name>F4F797_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10185"/>
    <dbReference type="EnsemblBacteria" id="AEB43155">
        <property type="protein sequence ID" value="AEB43155"/>
        <property type="gene ID" value="VAB18032_10185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10185"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OMA" id="GWGMFVR"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
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        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="65"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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    </feature>
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        <location>
            <begin position="205"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="413" mass="44399" checksum="0D1EE96543BFA684" modified="2011-06-28" version="1">MTSAAVLEHPGLLPGALDPTRPHARRTARDWLVDSLCFVAALGWVVVATLDAASPVPSYAERLPYPWMIPADAVIGVALAVALWFRRRWPVGLAVATLPLSAFSMTSVVSLLVIYFTVVVHRRTAVALAVTAGGLVANMFFALLRPDPDLAYWPTTTWGVAITLLVLAWGMFVRARRQLVLSLRERAERAEAEQQLRVAQAQQVERTRIAREMHDVLAHRISLLSLHAGALEFRPDAPAEEVARAAGVIRSSAHAALQDLREVIGVLRAEGSLATEPERPQPTIADLPTLVAESRAAGVRVDLHDEVSAADELPAATGRTAYRIVQEGLTNARKHARGAAVTVGLRGAPAEGLSVEIRNRWPVGEPDTDAIPGAGTGLIGIAERVHLAGGRLEHGRDGSGDFRLAAWLPWPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7A2</accession>
    <name>F4F7A2_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
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            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43160">
        <property type="protein sequence ID" value="AEB43160"/>
        <property type="gene ID" value="VAB18032_10210"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3085995_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="52" mass="5739" checksum="AD146EEB1B7C35BD" modified="2011-06-28" version="1">MRAIARFYQPVPADQRYGVRSAVACRGQPARPAVDWLGTLGRTEGRQARPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7C6</accession>
    <name>F4F7C6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_10330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731855.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10330"/>
    <dbReference type="EnsemblBacteria" id="AEB43184">
        <property type="protein sequence ID" value="AEB43184"/>
        <property type="gene ID" value="VAB18032_10330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10330"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_11"/>
    <dbReference type="OMA" id="FWGKMSF"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="11">
        <location>
            <begin position="8"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="585" mass="64772" checksum="9D3E859FFDFF796C" modified="2011-06-28" version="1">MTTVAPKPVVTRPWPVREPVKGSAIARMLRTTDAKQIGIMYMVTAFVFFMIGGLMALIMRAELARPGLQFLSPEQYNQLFTMHGTIMLLFFATPIVFAFGNYIVPIQIGAPDVSFPRLNSFAYWLYLFGGTMATAGFLTPGGAADFGWTAYTPLSTTEHAPGVGGNMWVMGLAISGLGTILGAVNLITTILTLRAPGMTMFRMPIFTWNMLVTSLLVILVFPLLAAALFALAADRLLGAQVYSPDTGGPMLWQHLFWFFGHPEVYIIALPFFGIISEIIPVFSRKPIFGYKGLVAATIAIAGLSMSVWAHHMFATGQVLLPFFSFLSYLIAVPTGMKFFNWIGTMWRGQISFESPMLWSIGFLVTFLFGGLTGVLLAAPPLDFHLHDSYFVVAHFHYVLFGTIVFAVFAGIYFWFPKMFGRMLDERLAKIHFWLTMIGFHTTFLVQHWLGNEGMPRRYADYQAIDGWTTLNMVSTIGAFITGISTLPFLYNCWKAYKAGPVVEVDDPWGHGNSLEWATSSPPPLRNFDRMPRIRSERPAFDAKFPELAAGQTIAGPPEGGSKPLTSESDGGASYTEDVASDIDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7F5</accession>
    <name>F4F7F5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AbyA5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">abyA5</name>
        <name evidence="1" type="ordered locus">VAB18032_16440</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2019" name="Angew. Chem. Int. Ed." volume="58" first="2305" last="2309">
            <title>An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis.</title>
            <authorList>
                <person name="Lees N.R."/>
                <person name="Han L.C."/>
                <person name="Byrne M.J."/>
                <person name="Davies J.A."/>
                <person name="Parnell A.E."/>
                <person name="Moreland P.E.J."/>
                <person name="Stach J.E.M."/>
                <person name="van der Kamp M.W."/>
                <person name="Willis C.L."/>
                <person name="Race P.R."/>
            </authorList>
            <dbReference type="PubMed" id="30664319"/>
            <dbReference type="DOI" id="10.1002/anie.201812105"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733054.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="PDB" id="4YWF">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A=1-355"/>
    </dbReference>
    <dbReference type="PDB" id="5NO5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B=1-355"/>
    </dbReference>
    <dbReference type="PDBsum" id="4YWF"/>
    <dbReference type="PDBsum" id="5NO5"/>
    <dbReference type="SMR" id="F4F7F5"/>
    <dbReference type="STRING" id="263358.VAB18032_16440"/>
    <dbReference type="ESTHER" id="verma-f4f7f5">
        <property type="family name" value="Duf_1100-S"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44394">
        <property type="protein sequence ID" value="AEB44394"/>
        <property type="gene ID" value="VAB18032_16440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16440"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771068_0_0_11"/>
    <dbReference type="OMA" id="IRCHIFG"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEK75501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="4YWF"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5NO5"/>
        </source>
    </evidence>
    <sequence length="355" mass="38584" checksum="3AA6524AA5569D9A" modified="2011-06-28" version="1">MSNDVAELKQYVLAHVSAQNASADGVLARIDDDGDGPRSWTTQWIRAGEEREQAGDLLAATTFYNLARFPFVDSPGRAEALRRCVAVFDRWRRTVPGIERLELRLPGGVVRAWAAGLSTTERRPVLLMTGGIVSIKEQWAPILPELARYGFAAVVTELPGVGENELRYDLDSAALFGVLLDAVAERADTSRAYALALSFSGHLALRAAPSEPRLRGIVTAGAPVAAFFTDKEWQAAVPRVTVDTLARLTQTTPATVFDHVRNWALTPQDLAGVRIPVAYVASGRDEIIPPADPALLRTHVRDFRTITHDDVHGSPAHFPHTRLWTLAQVLEMSGADPRHRAAVDGALAQVEGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7J0</accession>
    <name>F4F7J0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin synthesis protein P47K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16625"/>
    <dbReference type="EnsemblBacteria" id="AEB44429">
        <property type="protein sequence ID" value="AEB44429"/>
        <property type="gene ID" value="VAB18032_16625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16625"/>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1488417_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="1">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="19603" checksum="2122A2FF9245497A" modified="2011-06-28" version="1">MTVVVDSDHDQVGGGYIDRWYAAVPPVGGDLYVTSMELPSAPGDAGVGVHDVADADRAKNGGFLDDGRCDPVVVSGQWPQDPDERVELESRWHPVFGDRQQELVLIGVGLDGDGLRKALVGCLLTDTEVAAGEDAWRLLPDPFPGWTSVICTTTSRPTRCPHRSAWWGPRSVTQDVRPRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7U7</accession>
    <name>F4F7U7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding region atpase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734386.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23170"/>
    <dbReference type="EnsemblBacteria" id="AEB45734">
        <property type="protein sequence ID" value="AEB45734"/>
        <property type="gene ID" value="VAB18032_23170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23170"/>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087828_0_0_11"/>
    <dbReference type="OMA" id="REWLTTW"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="242" mass="25412" checksum="3AF8833FFBDFC47B" modified="2011-06-28" version="1">MTSRITCDVDDGTPVTVVRVAGGLDLTTTRQVYAVLERCLSTQPDALVVDLTGLTVHDQLAVAVFTAAARRAEGWPVVPMVICAPHPDPATSLAASTAARVVPVRHDCDEATRVADASAVARMRVRLEPVAAACRRARELVVDACARWDLPAAVEPASVVLSELVGNVVRHAGTPMQVTVTLRRPWLHLAVVDGSPAAAEPGRPGEHDEGGRGLLLVRELAARWGSAPAGDGKAVWATLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7W5</accession>
    <name>F4F7W5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding region ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735588.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29346"/>
    <dbReference type="EnsemblBacteria" id="AEB46940">
        <property type="protein sequence ID" value="AEB46940"/>
        <property type="gene ID" value="VAB18032_29346"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29346"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002554_2_2_11"/>
    <dbReference type="OMA" id="NTRDWPI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="4">
        <location>
            <begin position="53"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="519"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="931" mass="98061" checksum="FF157104D55CA791" modified="2011-06-28" version="1">MNTRDWPIRSKLTALVVVPVTALLALWIFATTLTFGPALDLLAARTLLYDLGRPGETVVAELQRERRLSVVQLASSRTNLPALREQRERTDAAVTQLRLRVSGEKFRDAAGELLEARLDRLLGKLEALPTGRAAIDRRDLDRIGAVNLYSDLVSAAFHTFEALANLPDHDLNREARALTDLGRSRELLGQTDALLAGALAAGGFAKGEHTLLVQSIGNQRFLLASAVADLPAPEQAAYQRLAEQDGFARLRAMQDELIAAGPSGRVTVDARAWQSGYDTVQQSLRDFELTQADGLADRSVPMAVSILARLAGAGLLGLIAVVASLVVALRIGRSLAQRLTLMRGRLKETAEQRLPDVVERLRRGEQVDVARETPVADQGTDEIGQVAQAFTEVQKVAIRAAQVEVTLRRGLNEVFLNIARRSQGLVHRQLALLDRLERDAEDPDHLAELFRVDHLATRLRRHAEDLVILAGATPGRGWREPVAMVDLIRGAISEVESYDRVDITDLQPAGTVGRAVGDIIHLLAELIENATAFSPPESRVQVSGAHVAHGYALSVSDHGLGMTAEAIEEANRKLARAPEFDPAETARLGLFVVARLAGRHGIRVRLRRSDGAGLTAVVLIPTELITAEPSALPPLDAMEGGDDASMEQRRLVRATRLTTVPRPRTRGGTSERPQSSRPSTKLGGPSQASTVGAAESDGLPRRIRRRPVGSTAEPTASSSITEAAEPTAEAAPGPTPAEPAGASAASAGSSAESAGSGVGPGGTEAESAAGSPGEAVSAGGDGASGRTVPTATDRGAVVDAPTIPLPALTRRSPGSGALDGPTLRQPLTIPAGSAGRLAEPTPRSPEEARRFMSALQSGTAQGRLAAARTQSADGRPAEVGSTGREGQGDPPAGRPSDETAAANRETSTDEAGPPPGGPVTVESLTVTERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F803</accession>
    <name>F4F803_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_29536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735626.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29536"/>
    <dbReference type="EnsemblBacteria" id="AEB46978">
        <property type="protein sequence ID" value="AEB46978"/>
        <property type="gene ID" value="VAB18032_29536"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29536"/>
    <dbReference type="eggNOG" id="COG2096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083486_0_0_11"/>
    <dbReference type="OMA" id="HQACTVV"/>
    <dbReference type="OrthoDB" id="1401910at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="20605" checksum="9DAB31AA6389A5CE" modified="2011-06-28" version="1">MAVHLTRIYTKAGDAGMTRLSNNEQVSKTDPRICAYADVDECNAAIGVALALGQLDDALRPVLGQIQNDLFDVGADLSTPVEPDPKYPPLRVTEGYVERLEGWCDEYNARLSNLDSFILPGGTAGAALLHVARTIARRAERSAWALVAHDPDRTSHLPAKYLNRLSDLLFILSRAANPDGDVLWVPGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F848</accession>
    <name>F4F848_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Group 1 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731880.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10455"/>
    <dbReference type="EnsemblBacteria" id="AEB43209">
        <property type="protein sequence ID" value="AEB43209"/>
        <property type="gene ID" value="VAB18032_10455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10455"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773428_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="178"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="354" mass="38244" checksum="5409D3EEB80E3B6B" modified="2011-06-28" version="1">MRVHFVLAQLEPLYGMERAAVLLMRALQEQGVEVSATVLSRSIPPGLDDLTVDTLGLGTRITRLLEAVPPLRRRLRNLPADVRIVASGLWASLPAGAALAGSGRRFVGWEHSLLPERLRFDRRVRTLARLARTNGLRPQLVVAVSDGVARTVRQLAPGQSVLTIPNVLPPKPFVPPREVADRERITLVTAGAFRPIKNHVGALEALALLPAHYHLTLAGDGAERELLHERASALGLAGRTTFLGRVPQVAGLLAEADVLLHPSRAETFGFSLLEAAEAGLPVAALPVPAVDEMIPTFVPGILARDTSPAALADAVVRLTGDQRPTVTDFEKAWHNRRAALDPAEVGRRWVEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F850</accession>
    <name>F4F850_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_10465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10465"/>
    <dbReference type="EnsemblBacteria" id="AEB43211">
        <property type="protein sequence ID" value="AEB43211"/>
        <property type="gene ID" value="VAB18032_10465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10465"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_0_1_11"/>
    <dbReference type="OMA" id="RPHALQH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="9">
        <location>
            <begin position="324"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="510" mass="55973" checksum="518F4B2E1C050C9F" modified="2011-06-28" version="1">MGFPATIAPGEEGSPRLGHRSESTETDDDGDPPHEGTAADAGSTPAENGDTARPGLDATAVLPYPGSRTSTRTRGLRAWMLTAPVDVAALLSPLLIDQQYWRGTLVMTALTVAIFAAGGLYQARRHVSILDEIPSLCGRLLAAAAIVVIIAALRHDSPEYLVEFIRGIAVAAVLVLAGRLLTREIATLARRQRWVEHNAIVIGSGPTAVELARLLRRYPRYGLRFVGHVDSPSATATSTTPLIGTLDQLEYLVRLTECDVLIIADPECPELVLMEILRHPKVATCDLWAAPRLWGSRSHGDHIGAIPIVKVGDTTLSGPHWALKRTSDVIFAATALLLLSPILLLSAGLAFLDGGRGIFFRQERIGRHGKPFDIIKFRTMRPLNEHESQTNWSIAHDRRVSPIGRFLRRTSLDELPQLWNILKGDMSVVGPRPERPYFVEKFSAEYPSYAMRHRVPVGLTGLAQVSGLRGDTPISDRARFDNYYIENWSLWLDAKVLLRTVAEVFRGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8H0</accession>
    <name>F4F8H0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733170.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17055"/>
    <dbReference type="EnsemblBacteria" id="AEB44515">
        <property type="protein sequence ID" value="AEB44515"/>
        <property type="gene ID" value="VAB18032_17055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17055"/>
    <dbReference type="eggNOG" id="COG1231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_9_1_11"/>
    <dbReference type="OMA" id="SDWAVGW"/>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309164" evidence="3">
        <location>
            <begin position="26"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="469" mass="51056" checksum="2AD615ADAA750D39" modified="2011-06-28" version="1">MSNTTLSGRPLTRRGVLTAVTAAAAAHTILRPSQASATRRRHAYDVIVVGAGFAGITAARDLRRKGLRVLILEARNRIGGRTWTSTFQGEQVEMGGVWVDPMQTHVWQEIEDQGIGLVADPAADRTLFPTATGFGYFSPEEAFGRQGELLTQFCEQAPQVFSDPTDPMAQADVLRLVDSYSIRDRLNAMGLSTLDEKWLSGATGGLGGGSDRGAYTQFLHWWALCNYNAEQYYGINTYRPAGGMTGLAQAILTEAAADLRLNSPVRSITDNGREVTVRTRAGMSYTASSVVVAVPVNVWNTIDFAPGLSLQRRRASSETFGVPGAQKLWLRLRTSLGNTYVHTPDGYPVDTLVPIKQFADSQLMVGFSNDRRLNVNNVAQVERAVRLVVPDARVLAVKGQNWGADPYARGGWSFRRPGQLTGLLDAIQRPQGRISFATSDIASGWSGYVEGAIESGLRAAEQVTHYAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8H7</accession>
    <name>F4F8H7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_17090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733177.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17090"/>
    <dbReference type="EnsemblBacteria" id="AEB44522">
        <property type="protein sequence ID" value="AEB44522"/>
        <property type="gene ID" value="VAB18032_17090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17090"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_35_8_11"/>
    <dbReference type="OMA" id="LGGCTQK"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="920"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2579"/>
            <end position="2654"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4296"/>
            <end position="4374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="877"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="955"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2614"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="4441" mass="458657" checksum="756C485CFDDA3441" modified="2011-06-28" version="1">[encoded data, 4441 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F959</accession>
    <name>F4F959_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04805"/>
    <dbReference type="EnsemblBacteria" id="AEB42087">
        <property type="protein sequence ID" value="AEB42087"/>
        <property type="gene ID" value="VAB18032_04805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04805"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047963_1_1_11"/>
    <dbReference type="OMA" id="FKSEVQP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="180"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="253" mass="26855" checksum="A400903AD9AF3A1B" modified="2011-06-28" version="1">MSVLQRFEKRLEGLVEGAFAKVFKGVVHPVEILNAMQREAEAHKAILAGGRTLVPNRYVIDLSPYDHSRLAPYAAALAQELAQSQAEFIGEQAWTVYGDVIVEIERGEGLDTGMFRVTAEVYTGGEVAPVSAPGYDAGPSGYPAYEQGGGYGPPPGHGGGRNVRLVSGDGRTYPLQMGSTVIGRGDQANLRLPDVGISRRHARLDFDGGQVVLTDLGSTNGTMVNGQRVSAVALNPGDMIQLGTTTLTFRVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9D1</accession>
    <name>F4F9D1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731996.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11035"/>
    <dbReference type="EnsemblBacteria" id="AEB43325">
        <property type="protein sequence ID" value="AEB43325"/>
        <property type="gene ID" value="VAB18032_11035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11035"/>
    <dbReference type="eggNOG" id="COG5343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082046_0_0_11"/>
    <dbReference type="OMA" id="YQEVWLI"/>
    <dbReference type="OrthoDB" id="1972141at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="25944" checksum="BDDD1A1D8DFD4074" modified="2011-06-28" version="1">MQHLEHDRLIFLALGEGKADNADRTHLDACSHCRAELAGLREVAGLGRSTQSLRDLPDPPEHLWQGITAEIRTAEQLPTLTTARPQPADQRDGPVAPRSRRPRRWVRYAVTAVAAAAVGIAGTAAVLREGTPPPPPVTASAQLAAYGSTPPQARGDARVLGTGELHLHVANLPPVSGYYEVWLINPQNMEMFSIGVLGGGSDVLLPLPPNVDLGQYSVVDVSAEQFDNNTAHSGDSLLRGSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9H9</accession>
    <name>F4F9H9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vanz family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17275"/>
    <dbReference type="EnsemblBacteria" id="AEB44557">
        <property type="protein sequence ID" value="AEB44557"/>
        <property type="gene ID" value="VAB18032_17275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17275"/>
    <dbReference type="eggNOG" id="COG4767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090667_0_0_11"/>
    <dbReference type="OMA" id="WWARRIV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="19374" checksum="240C44C984846A30" modified="2011-06-28" version="1">MIPGGYLRWLPVVATAAALTVAGLICTRHLVACYRKRGVPAGPAVRRAWATTVMSVWTLPWLVVVLTPLDAPRDVRLVPLRDLVEILADPPLTAFFQIVGNLLVFAAVGFGLGMAWQVRLTHVVIVAAGMSTAVEVSQYALALGRVSSIDDVLLNTTGAGLAVLAARRLPVPDRLLPVPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9S8</accession>
    <name>F4F9S8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide synthesis cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23780"/>
    <dbReference type="EnsemblBacteria" id="AEB45854">
        <property type="protein sequence ID" value="AEB45854"/>
        <property type="gene ID" value="VAB18032_23780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23780"/>
    <dbReference type="eggNOG" id="ENOG50332TT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2207266_0_0_11"/>
    <dbReference type="OMA" id="LYCLHDL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006765">
        <property type="entry name" value="Polyketide_synth_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038474">
        <property type="entry name" value="Polyketide_synth_cyclase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04673">
        <property type="entry name" value="Cyclase_polyket"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="98" mass="10936" checksum="43F0786799A7053C" modified="2011-06-28" version="1">MAQIFAESDATELPGLTGVRHRSLYCLHDLCVHLMETEDVGADALATARNHPLYRQVNERLSAHTSPYLPTWRSPRDAIANCFYRWDGADVPAPRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9X7</accession>
    <name>F4F9X7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_00020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00020"/>
    <dbReference type="EnsemblBacteria" id="AEB47088">
        <property type="protein sequence ID" value="AEB47088"/>
        <property type="gene ID" value="VAB18032_00020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00020"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_1_1_11"/>
    <dbReference type="OMA" id="NAKAWLF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="207" mass="23555" checksum="87B2658808FAF8FF" modified="2011-06-28" version="1">MRLTTEKTDERRARFERDAMPFVDQLYAAGLRMTRNPADAEDLVQETYLKAYAAFHQFEQGTNLKAWLYRILTNTYINTYRKRQRQPVQAPTDEITDWQLAEAESHTSSGLRSAETEALDRLPDSDVKEALQQLPEEFRLAVYLTDVEGFSYKEVADIMGTPIGTVMSRLHRGRRNLRKLLEGYAAERGFSAAPSARSSAAASGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9X8</accession>
    <name>F4F9X8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_00025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735736.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00025"/>
    <dbReference type="ESTHER" id="verma-f4f9x8">
        <property type="family name" value="NLS3-Tex30"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47089">
        <property type="protein sequence ID" value="AEB47089"/>
        <property type="gene ID" value="VAB18032_00025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00025"/>
    <dbReference type="eggNOG" id="COG3571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072792_3_0_11"/>
    <dbReference type="OMA" id="HSFKPRK"/>
    <dbReference type="OrthoDB" id="1090356at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="21110" checksum="AA6C5912EF58DBDE" modified="2011-06-28" version="1">MPQDEIIQTPRGPARVDIDTPTGPGSSLLVLGHGAGGGVDAPDLCALRDAAVSAGVIVARVTQPYRVAGRRAPAPAGHLDEAWGVVLAVLRDRWPGVPVLVGGRSSGARVACRTAITVGAVGVVALAFPLHPPARPERSRAGELASGVPTLVVNGDRDPFGVPEPAPGVHVVIRPGERHDLRLDPTGTAAVVLDWLRRHGWAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA81</accession>
    <name>F4FA81_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="8" type="ordered locus">VAB18032_05080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730816.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05080"/>
    <dbReference type="EnsemblBacteria" id="AEB42142">
        <property type="protein sequence ID" value="AEB42142"/>
        <property type="gene ID" value="VAB18032_05080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05080"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_4_0_11"/>
    <dbReference type="OMA" id="VVIRDNR"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="26767" checksum="713ACBB8EA5A50A9" modified="2011-06-28" version="1">MTEQPRAADPGDTGSAPGGSASEPAAGDAPRVVIRNNRKISQTSEPEGAAADAGSDVPAEGLVEDAEVVVDAIQVEAAALSEPATDGPPVVDSPASPVGESTAEKGSDGAAGGLGAELAALRSDLDERTRDLQRVTAEYANYRKRVERDRALVTEQATGSVLAALLPILDDLDRAREHGDLVGPFGSVAEQLIAALGKFGLTPFGEQGDPFDPTRHEAVAHQTSPDVTEPTCVQVMRRGYQMGERLLRPAMVAVADPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA90</accession>
    <name>F4FA90_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730825.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05125"/>
    <dbReference type="EnsemblBacteria" id="AEB42151">
        <property type="protein sequence ID" value="AEB42151"/>
        <property type="gene ID" value="VAB18032_05125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05125"/>
    <dbReference type="eggNOG" id="ENOG502ZAA0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255526_0_0_11"/>
    <dbReference type="OMA" id="YPSWWIP"/>
    <dbReference type="OrthoDB" id="2095814at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="22371" checksum="9B9939DA28A72177" modified="2011-06-28" version="1">MSYPEQVPVGRPGAVRLAVAVLAVMALGALGYALAGLIAFGGIGDRLRAAAAGSSQSGSEIDAMATLLRTSVLLSTVVSVLAGFLLAGLALGVAAGRSGARVGTWVVAGFGVSFGCCGLLVQLIQYVTPLNLRNDPSLTELFGLAADGYPSWWIPLTVTLSVAQVLGYLVVAVLLALPSVGPWFRRRSAPAATPPQPGGAPPYQPYPPPGAAPPPSYPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAS3</accession>
    <name>F4FAS3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17930"/>
    <dbReference type="EnsemblBacteria" id="AEB44688">
        <property type="protein sequence ID" value="AEB44688"/>
        <property type="gene ID" value="VAB18032_17930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17930"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311889_0_0_11"/>
    <dbReference type="OMA" id="RNCRLPV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="947" mass="102387" checksum="1470CF34F07E1433" modified="2011-06-28" version="1">MTAPAPANNAVSTSTAAPASAAVGAFAALREQLTDAAAAFAGGPDALADILTGIVDDVDRALGERLEIFPVCHHSPASALAMVRRLRQKQPRVIYLELCEDLQPVLTELRNCRLPVAVQAFASELDGFPAAWAPLSVIAPVTEASAEYQAIAYALETPGVELVLVDRSTDHVFQWSPRDESPASEESTVDGSDDQAALHGDAVGVEIGDLRPRFAELEAYLLHHGKVRHWSEWWDSYVERPLATADHDTYRQVMVLIGSLFRRLRPSSSERTDRDEDRERYMWTRIRQHLAATGADPADCLYVCGAFHAASRVEQFGLDSPAPDFDITDRTATRWQYGLIPSSHSAIEAQFGLAPGSVSIAAATWNKAVSASGVTPYRLGGQRGATGRKRRGKPEAVPVGPVTDRLSGFLAAPPTPDGLDEAELRRWCVDIVRLARRNGYLASTADAIAVFETSILLAGLRNRARPTPYDFADAAVTCIEKDVVPGRRDVRRLCEILLGGDRIGQVGYDALPPLARDVLHRLEPLGLDLEKRTVQRALLDLQGSPELAGCSDLLWMLRHLLPPGAVRPIMGERRLGHRSIQESWDLAVGRHQRALIELGYEGVTVEQVLEQRLRRAAHGPEATAVSALAAVEDAITLLNSPRLVEELGARAVELLAGERTVDDAPEVLRRIRRLLAHHQATATGLPAWCEAFVTTGYAHYCTLLPTAFVDGETGVRQVGAMLGFLFSLESLALSLGCDRSQLELAVGQSHPEAPPKVALLWAAHHQLGMLPLAQLRQRCRQLLSNPLVVPAFPQYLSGFVHALEPVPGLTPFVVETMSTAFARLPDPVLLPWLPNLITALRAHGPELVPLLVREAGRTFPGTLSALDSWVPPWSGTAPAAAPVIGQRPVGQVHGLLAEYREPVDAVAALLGVEGGWQSPDDGVTDSGVLVQAHPGSAEAIARVLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAT2</accession>
    <name>F4FAT2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17975"/>
    <dbReference type="EnsemblBacteria" id="AEB44697">
        <property type="protein sequence ID" value="AEB44697"/>
        <property type="gene ID" value="VAB18032_17975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17975"/>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368784_0_0_11"/>
    <dbReference type="OMA" id="WHKLRLY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="89"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_16" evidence="2">
        <location>
            <begin position="388"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="755" mass="82713" checksum="8FF5E0B5AD896E02" modified="2011-06-28" version="1">MTEMRTYELEIFDQTSDYSELRLSTGVGAPKTRGVDRAAIGRLIGLMERDYSQHAVVQRVFGAPQLRDLGTKLAEFLDGDERWLTAVLGRPPGTTLRITAAEGFRHLPWELLAADGSYLAVSGHAPLLPVRAIGTHAALTAPVEPANRPLRVLFMATSPEGVEPVLSFEAEEAAILDATRRTGTELVVEESGTLDGLRFLNLDYGAGYFDILHLSGHANISADGQPVFLVENEFGGLAYATADQIAQAVSGRWPRLVFVSGCLTGNSPGSGAFPSMSESLVRAGAPAVLGWALPVGDVSATEFAAELYRSLADGQPLDRAVVEARQHLYANKRANWHLLRVYADRSPLARMVTPLHTKGRARIQIRAADQEFLDPQTQLSRVASRATFVGRRRAIQRCLRTLKQPQGGDGAADALVLQGMGGLGKSSLASRLLERMPTHQRAVWYGRVDLTKFRELTDKVDFPTREQQVEANELLEDQRLSLAVRLRRLLHVDGPLGQTPCLFVFDDFEDGNLDERDGGHVLAPEMADILPALLKAIRDTGSPSRVIITSRYRFHPPAGTSIRFESLETLTDVEQVKKLTNLPNLRPGSPVDPDIRDRAIEAAAGNPRLLDWLDLIVAAPNLDIDSLITAIEAEADRFRRETILAKNLLDSQNPELQNMLAKVNVVELPVPADTVRALHDHPDATAHIARAVQLGLMEEGTDPETNQPRYYVSNVLRPLIRPLITDDEYTQACAAAARSLYKLWITDPATSGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB77</accession>
    <name>F4FB77_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMP dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735867.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00690"/>
    <dbReference type="EnsemblBacteria" id="AEB47222">
        <property type="protein sequence ID" value="AEB47222"/>
        <property type="gene ID" value="VAB18032_00690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00690"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064068_0_0_11"/>
    <dbReference type="OMA" id="AARRDYM"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="17"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="39506" checksum="0981BEE737AE6EB4" modified="2011-06-28" version="1">MRDVVEIGLGKTAQRGYHLDDIAIVPSRRTRDVDDVSTGWQLDAYQFGIPCVGHPSDATMSPASAVRLGQLGGLGVLNVEGLWTRYENPTKVLEELAGLGEDARATKRLQEVYAEPIRPDLITERVRELRSGGGTVAVRVSPQHTLALAPVILDAGVDLLVIQGTIVSAEHVSTTDEPLNLKEFIADLDLPVIVGGCTDYKTALHLMRTGAAGVIIGIGGDEWSTTESVLGIRVPMATAIADAAAARRDYLDETGGRYVHLIADGDIRTSGDIAKALGCGADAVMLGEPLSLCAEAPAGGAWWHSAASHPSLPRGAFEVAGEPLGSMERLLFGPADEPDGQLNLFGGLRRAMAKCGYRDLKEFQKVGLVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBF9</accession>
    <name>F4FBF9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05645"/>
    <dbReference type="EnsemblBacteria" id="AEB42255">
        <property type="protein sequence ID" value="AEB42255"/>
        <property type="gene ID" value="VAB18032_05645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05645"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029927_6_1_11"/>
    <dbReference type="OMA" id="VCELWRS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="423" mass="46985" checksum="182E573F3AA49610" modified="2011-06-28" version="1">MEQGYVSRIIAGRKVTSIDVLERIADGCAMSDEARMTLGLAPRERSYRADMADHRNIRHSDLPANRSWHEDVRAAAQLWEGDVNRRELLRQTVFSSAAYTLPALRWFTATSTQPVTQDGRRTVGQPDIDTIREMTATYRRLDNQHGGGHARANVTRYLHHEVTPLVTEGRYDPATGRKLLAAVAELTQLAGWQAYDMAEHGLAQRYLTHALDLARNADDAGLGAEILAAMSHQATYLGHTATAVDLARAARQTAHCAGITVLTAEALVMEAHAHAAARDEHACATALHQAEQALDRADRTGDPQWLGYFDEAYLSAKFGHCFNALGQHSQAERFAARSLHMDERYVRGKAFNLALLATIQARHGEPDRASIIGGQALTLTTQLKSARAVRYIRDLQTDLMPHRRRPAVRHFITRIDATLGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBH2</accession>
    <name>F4FBH2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730941.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05710"/>
    <dbReference type="EnsemblBacteria" id="AEB42268">
        <property type="protein sequence ID" value="AEB42268"/>
        <property type="gene ID" value="VAB18032_05710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05710"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_1_11"/>
    <dbReference type="OMA" id="GLRICEA"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="199"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="45526" checksum="8104390863A749A7" modified="2011-06-28" version="1">MPGRARANGEGSIFPYRNGFAAYVWVEKPDGKRGRKWVYGKTREEVHDKWIKLHGQAKAGPVATRSPTVGEYAGYWLREIVKPNLAPGSYVTYEVVVRLYLVPGLGRKRLDKLRVSDVQTWINEVGRTCQCCAQGKDERRKPVQRRCCALGRCCRDLPSPTSVTHLRTVLRTLLSQAITEGLITRNVVSLVKLPPVRKRKRKAWTSDEARRFLESARADDDPLYAAYVLVLVLGLRKGEMLGLTWADVDLDAGELTIDRQLQRVGAELLHRETKTAASDATLPLPDICTVALGRRAAQISARDAAGPAWQPSDLIFTTRYGRPVEPRNFNRFWDRRCDAAGVRRITVRDARRTCASLLADLDVHPRVAMQILRHAQFAITMEIYTVVSSTATRDALKRLGSALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBK6</accession>
    <name>F4FBK6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732137.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11770"/>
    <dbReference type="EnsemblBacteria" id="AEB43468">
        <property type="protein sequence ID" value="AEB43468"/>
        <property type="gene ID" value="VAB18032_11770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11770"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_0_11"/>
    <dbReference type="OMA" id="NQRRDQY"/>
    <dbReference type="OrthoDB" id="1033671at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="37574" checksum="566C1D0F6F944D5A" modified="2011-06-28" version="1">MSTLFTPLTLRAVTLPNRIALAPMCQYSAGPDGLPHDWHLVHLGTRAVGGAGLVMTEATAVLPEGRISPQDTGIWSDRHVDAWRPVTRFVAAHGAVPVVQLAHAGFKASTYRPWDPHRGGVPDAEGGWTPVGPTEQPFLPEYRTPTALDEAGIAAVVEAFAVAADRALAAGFAAVEVHAAHGYLLHEFLSPLTNHRTDAWGGDRAGRMRLTLEVARAVRAAVGEQVPVLARISATDWVEGGWTVDDSVALAVELARAGVDLVDCSSGGASPNATVPVGRGYQVPLAAQVRREAQVPTGAVGLIVEPEQAEAIIADGEADLVLLGRELLRNPYWPRQAAAKLGAETTWPEPYLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBT4</accession>
    <name>F4FBT4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
                <shortName evidence="15">ACCase subunit alpha</shortName>
                <shortName evidence="15">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
                <ecNumber evidence="15">2.1.3.15</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
                <shortName evidence="16">ACCase subunit beta</shortName>
                <shortName evidence="16">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">accA</name>
        <name evidence="16" type="synonym">accD</name>
        <name evidence="19" type="ordered locus">VAB18032_18160</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the AccA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the AccA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="15"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733389.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18160"/>
    <dbReference type="EnsemblBacteria" id="AEB44734">
        <property type="protein sequence ID" value="AEB44734"/>
        <property type="gene ID" value="VAB18032_18160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18160"/>
    <dbReference type="eggNOG" id="COG0777">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_2_0_11"/>
    <dbReference type="OMA" id="RVLMCAN"/>
    <dbReference type="OrthoDB" id="504557at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="17">
        <location>
            <begin position="13"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="18">
        <location>
            <begin position="265"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="16">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AEB44734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="542" mass="56815" checksum="E7EA9E539EEBEE6F" modified="2011-06-28" version="1">MTSAEVTAETARGFARCPACGLITYTRRLVRTGRVCPECGAHGRLSAPERLAQLLDEGSATALPADDPVRDPLAFTDARAYPDRLALARRATGLTEAVVCARGTIGGQPVTVAVMDFGFLGGSLGTVVGDRITRAAEAALAERTPLIIVTASGGARMQEGVFSLMQMAKVSQAVAALDDAGLLTVSIITEPTFGGVAASFATCTDVLIAEPGARMGFAGPRVIEQTVRERLPEGFQTAGFLLEHGMIDMVVPRGELRPVLCRLLAVTRPAVFAEVADVVIRDPATLPEVDAWDVVRAARDPARPTTLDYATALLDGFVELHGDRLAGDCPAIVGGVGVLRGRPVLLLGHQKGHDTRELVRRRFGMASPEGYRKSSRLLRLAAKLKLPVVTLVDTPGAYPGIAAEQRGQALAIAEIIKQLCSLPVPVVSVVTGEGGSGGALALAVADRVLCRESGFYSVISPEGCSAILWKDAAAAPQAARALRLGARHLLASSVVDGVVPEPSDPAAAMAAVGDAVAVTLAALDHTDRRELVANRRARFRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC36</accession>
    <name>F4FC36_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24680"/>
    <dbReference type="EnsemblBacteria" id="AEB46034">
        <property type="protein sequence ID" value="AEB46034"/>
        <property type="gene ID" value="VAB18032_24680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24680"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_13_2_11"/>
    <dbReference type="OMA" id="KRTMIWC"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="415" mass="44767" checksum="91354F75AFC54CFE" modified="2011-06-28" version="1">MREHDFRQLFVADAVSQLGIQVSLMALPLVAVLALQADQFEVGLLAACETAAFLFIGLPAGAWVDRWRRRGVLIAGDLVRALVLITVPLAWWGGWLTMPQLYAVALLIGVGTVFFDVAYQSYLPHLVRPDQVIEGNSRLEAVRSVNWVAGPAAGGLLVQWLTAPYALVVNCVTYLVSALFVVRIRRREPLPVPSPGASLRREIVEGLRFVIGHRLLRATASCTSLANFFGAMTTVMQVILLARVLELAPGAIGVFLSVVSAGAVLGAVAVRPIVARLGQGPTIWMAMAFSAPFGLLLPLAERGWLLWLAAAGSAVSWFGCVVYNITQLSFRQLLTPPRLLGRMNATMRFLVWGSMPVGSIVAGVLGQHLGVRPVLWIAAIGQMLVFLPTFLSPLRHMRVLPTAASDSPAKELSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCD9</accession>
    <name>F4FCD9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ordered locus">VAB18032_01170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735955.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01170"/>
    <dbReference type="EnsemblBacteria" id="AEB47318">
        <property type="protein sequence ID" value="AEB47318"/>
        <property type="gene ID" value="VAB18032_01170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01170"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_11"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="397" mass="44092" checksum="60948B390C7DB2E6" modified="2011-06-28" version="1">MAKAKFERTKPHVNIGTIGHIDHGKTTLTAAITKVLHDQYPDLNPYTPFDEIDKAPEEKARGITISIAHVEYQTEARHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYIVVALNKSDMVDDEELLELVELEVRELLSSQEYPGDDLPVVRVSALKALEGDPEWTGRLLELMNAVDTAIPQPERETEKPFLMPIEDVFTITGRGTVVTGRAERGILKPNEEVEIVGIREKSQKTVCTGIEMFRKLLDEARAGENVGLLLRGIKREDVERGMVVIKPGTTTPHTEFEATVYILSKEEGGRHTPFFQNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTTMTVKLIQPIAMEENLKFAIREGGRTVGAGRVTKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCW0</accession>
    <name>F4FCW0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyketide synthase modules and related protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733447.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18450"/>
    <dbReference type="EnsemblBacteria" id="AEB44792">
        <property type="protein sequence ID" value="AEB44792"/>
        <property type="gene ID" value="VAB18032_18450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18450"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_30_2_11"/>
    <dbReference type="OMA" id="AFWCARR"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="929"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1912" mass="202104" checksum="78EC6C96B4BAC1F1" modified="2011-06-28" version="1">MSRIAVVGLACRYPDAASPGELWENVITGRRAFRRLPDERMRLADYWDADRSVPDRFYARNAAVIEGYEFDRQKYRIAGSTYRSTDLTHWLALDTAARALGDAGFPMGAELPRERTGVVVGNTLTGEFSRANVMRLRWPYVRRTVGAALREQGWDDDQLADFLGTLEQRYKAPFPAIDEDTLAGGLSNTIAGRICNYFDLKGGGYTVDGACSSSLLSVLTACRSLVEGELDVAVAGGVDLSIDPFEIIGFAKTGALARGEMKVYDQGSNGFWPGEGCGMVVLMRHEDAVAQGRRIYASIAGWGMSSDGKGGITRPEEDGYRLALTRAYARAGFGIETVPMFEGHGTGTEVGDATELRALTEARRAAGASGTPAAISSIKAMIGHTKAAAGVAGLLKAVLAVHHQMLPPTVACEEPHEVLTSNEAKLRVLPTAEPWPADAPLRAGITAMGFGGINTHLVVSGEETARRSPDARTRTIAARAQNVELLVLDADTPAELAERVHALAGQVIRLSYAQLGDLAASIYTELGDRPYRAAVVARSPEDAERQLLRVHAALQAGESRLYAADGRAFLGHVRGAARVGFLFPGQGTGRGRPAEALRRRFTQADRIVTEAALPTGDVVATEVAQPRIVTGSVAGLSVLSALGIEADVAVGHSLGELTALHWAGAMDLSSVLRMAAARGRTMAEHGRPGGTMAGVPADPETARRLLSGEPVVIGGYNSQRQTVISGPIDAVERVLERAEVAGIPGKRLRVSHAFHSPLVAEAAEAFGGYLAEERFQPLQRQVVSTVTGTVLPADVDLSVLLRDQITEPVLFAQAIAMAAKEVDLFVEVGPGRILSDLGRTDTSVPTVALDTDDETLASVLRVVAAAYVVGAARVHPQLFDGRLVRPVKDVDEFSFFASPCETDSDVVLPDSPPPVAAPASVNGAAPTGEPASLVLRQLVAARAELPLDMVGEDSRLLDDLHLSSITVSQVVNQAAQQLGVPPSRLPTNVATATVREVAEAMEALIGTGLAEDLTQPASVPGVDTFIRAFAVDLVEAPTPVPGPAETNAGWQLFGGHTDPRAEQARQALAGGGVGGGVLVWLPADCTPEQLEPALQGARAALTAGAGDRFVLVQHGLGASGLARTLRLEDPRIRTTVVHLPATLDVADRVLAEVAATDTYHEVHYDVTGARRQQVLRALPIDAGRVEQPLDAGDVLLVTGGGKGITAECALALAADAGAKLAVLGRSDLAADAELAANLERFAAAGVQARYLRADVTDPVAVRAAVDEVERLLGPVTGVLHGAGRNEPAALTSLDMDAVHGALAPKVGGLAAVLDAVDADRLKLLVTFGSIIGRAGLRGEAHYATANDRLAEQTRRFGAAHPTCRSICLEWSVWSGVGMGEKLSVVESLARDGITPITPEQGVAVLRRLVTDPDTPAVVVISGRADSLDTLRFEEPELPLLRFVDRPQVRYHGVELVTDIELTAGSDLYLPDHLLDGNLLFPAVMGMEAMAQAAMTVTGRSEVPVIEQARFARPIVVPPHGSTTIRVAALVTADDTVRAVIRTADTGFAADHFEATLRFVEGPVPDGPPEQVADDLPPVPLDPARDLYGDTLFQGARFQRLRAFHRAAARDVDADVATVPETDWFSAYLPDTLVLGDPGVRDALMHGNQVCVPDATLLPVAIARLYPAGSRMGTGEPLRYCATERERDGDTYVYDIALRTGTGEVVERWEGLQLRAVRKKDGRGPWVAPLLGSYLERTLGDLIGTAIAVAVEPNAGDQPELAVGRALGHAADLRYTPDGHAEQVDGRYVAVSHGAELSLAVAARTPVGCDVRPVSPRPVDSGAPVLGRYEALVDQVVTGFGVDRDTAATQVEAALDCLRQVDLPEHLSVTLTPIQRDGWLVFAAGATRVATFATTVGPAATPVVFTVRTDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCY2</accession>
    <name>F4FCY2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733469.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18560"/>
    <dbReference type="EnsemblBacteria" id="AEB44814">
        <property type="protein sequence ID" value="AEB44814"/>
        <property type="gene ID" value="VAB18032_18560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18560"/>
    <dbReference type="eggNOG" id="ENOG5033D9Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079857_1_0_11"/>
    <dbReference type="OMA" id="FNGYAKQ"/>
    <dbReference type="OrthoDB" id="1959063at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="26756" checksum="21410BA24DEB0B49" modified="2011-06-28" version="1">MRLRYTSDDDADQEKPFWQHRRWQMSAGFLALALCTGTVAAIGGGRDASPSVAATPGPVIGSLGPDGSRPQGCRTDDSAQRIPTTAPDDISWRPLNGARVPRSASAGPRKTTGPLLWCFAHTPMGAVMAVHTISRQMSGPDWRTVSHQQLVPGLGRDYFDAMRASMDETGPVQTVNTLAGFLVLRYSPSTATVRVLIRQANVLYASVDYTVDWNGVDWRLRPLNSGGLHTRAAPVVSLVGFVLWDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD24</accession>
    <name>F4FD24_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18770"/>
    <dbReference type="EnsemblBacteria" id="AEB44856">
        <property type="protein sequence ID" value="AEB44856"/>
        <property type="gene ID" value="VAB18032_18770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18770"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598446_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="457" mass="50085" checksum="A0CBCC1C83086E24" modified="2011-06-28" version="1">MEIREIAPGGDESLARALLAVQHAAYAVEAAIIGDDRIPPLHETLDEVRAAPLRWLGAFQEHRLIGAIGWSQDDSVVDIDRLVVDPAAHRRGAGRALVGAVLASAGHRRVVVATGRDNRPARGLYEGLGFVRTGEVEVIPGLWITRYAHPPTAVQSAKDAVGASDRADRTGPLPAVSGWDEALAPRQRALLRRWLPGATLVRDHSWGLVATRVIEVSCAGSRFIVKAGGADDRHIERELHAHRTWLRPWTDRGRAPMLVHGSAEDQLLVTRYLPGELVLGTGHADQSDTYRQAGELLALLHAQSAVVDDDYERRENERSLAWLDRPHRIAAGTVARLRAEIADWPTPPATLVPTHGDWQPRNWLVHDGVVSIIDFGRAALRPALTDFARLAVQDFRRDPRLEAAFLDGYGADPREADAWYRTLVRAAIGTAAWAHQVGDESFEAQGHRMLAEVLAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD70</accession>
    <name>F4FD70_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8 and S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_25010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734752.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25010"/>
    <dbReference type="EnsemblBacteria" id="AEB46100">
        <property type="protein sequence ID" value="AEB46100"/>
        <property type="gene ID" value="VAB18032_25010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25010"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579928_0_0_11"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="194"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="471" mass="50772" checksum="BA6930D3476AF277" modified="2011-06-28" version="1">MTIKPRHPSASAPDEFPEHRSGKQLKIDAAHVRRQLQVMLVDARRGRTSEIIDQMRERQERAPRQFALPFDRYPVTDLAGRRTYVLVARGQLVVDFEASRPESDPQRVLRRLGYRPWQRGWSPERPTRVFEGRKTPQELAGDVGQLTKLGITAAPHLVVPLGHIIKGDDYPFATAALGDFPQTAAAGRPGAPAVRVAVIDTGITPEDRTDSWLDSIDRRSDNTELLDVLPVVNGRAGDGRLDWSAGHGSFAAGIVQRVAPRCEVRAYRFTRSDGLGTDKDAAEAMLRAVHEAAADGVRLIINASIGTPAVDGVPPLALQSAVRTIVDRFPEVLIVASAGNNGSKDPMYPAAFDGVVAVGALTADLQPAPFSSHGDWVDCSCVGVGVVATFVTGTLPPVPDPAVADYTFPANSWAVWSGTSFSAPQISGLVARACLNDPKLTPRDAWDALLAGRHTLPDYGRVLRVLPGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDE6</accession>
    <name>F4FDE6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase groes domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_01365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01365"/>
    <dbReference type="EnsemblBacteria" id="AEB47357">
        <property type="protein sequence ID" value="AEB47357"/>
        <property type="gene ID" value="VAB18032_01365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01365"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_1_0_11"/>
    <dbReference type="OMA" id="MCRNGRY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="3">
        <location>
            <begin position="142"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="345" mass="36537" checksum="1897B957D026B9AA" modified="2011-06-28" version="1">MTVIPGVPGSLRLLDDYPEPTTEEGSILVEAVAVGVCGTDLEIIEGKYGEAPPGTDHLVLGHESLGRVIEDPTGTLQAGDLVAGIVRHPDPVPCPNCAVDEWDMCRNDMFTEHGIKALPGFARQRWRVQPRFAVGLDPALGEVGVLLEPTSVVVKAWDHIFRIGQRAEWQPRTALITGAGPIGLLAALLASQRGLSVHVLDLATDGPKPALAGALGATYHAGSIDKLDFEPDVIVECTGAPAVVLEAMYKVAPTGIVCLAGVSSGGRTVDLDAGSLNRTLVLENNVVFGSVNANRRHWDEAAKALSRADRSWLASLITRRVPLSEYAAAYSPGPQDIKVVLDFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDL7</accession>
    <name>F4FDL7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731053.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06280"/>
    <dbReference type="EnsemblBacteria" id="AEB42380">
        <property type="protein sequence ID" value="AEB42380"/>
        <property type="gene ID" value="VAB18032_06280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06280"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042654_2_0_11"/>
    <dbReference type="OMA" id="DLDPWGG"/>
    <dbReference type="OrthoDB" id="1646147at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="365" mass="37612" checksum="036750C8BFD90C53" modified="2011-06-28" version="1">MPSRTSVPPHRRPPLVVTADGDLLDDLLRLAAAGDVEVEVAADPAAARTRWQPAPLVLVGADQAQPCLRARLPRRSRLVLVGRAEDLDPGWQVADLLGAEHVAVLPAAEPWLVDRFAECGTDGTAAARVVAVVGGRGGGGASILAAGLAVTAARGRLRTLLLDADPLGGGLDLVLGWEQLEGLRWPALSGADGRVDPPALVRALPSRGDLVVLSWDRGDPVAVPAEAMASTLDAARRGRDFVVVDLPRQFDDAAVTALQTADRVFVVVPAELRATAAAARVVAVAAPNCQDLSVIVRGPAPGRLRAAEVARALGLPLAGTLRPEPGLCRGLERGEAPAAGGRGPLAELCQRIVADLTGRTVAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE28</accession>
    <name>F4FE28_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metalloprotease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44897">
        <property type="protein sequence ID" value="AEB44897"/>
        <property type="gene ID" value="VAB18032_18975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18975"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007507_0_0_11"/>
    <dbReference type="OMA" id="ANTHEAW"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307838" evidence="3">
        <location>
            <begin position="20"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="5">
        <location>
            <begin position="65"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="481"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="923" mass="97495" checksum="60EA9FAA1936EACD" modified="2011-06-28" version="1">MLSTTLVVSLTSVSAPASAAPEEDAGTSNPIFLTGPNEGAPEAVAVNYLRANPVQHGVNAADLSDLAVASMYTSRHNGVTHVNLAQRHQNLEVFGATATVNLARDGSVVFVGDSLVADLAEKASGAASLDAVEAVEAAAEALDLADPKSPRVMSRAGGAAQRTVISGSGISEQPIPAKLGWQPTDDGLRLAWQLVIDDSSDPHLWNVAVDAQTGELLDSDDWTSHDHPKDLAATLGRPEQHAATTAADIEIPTVLPRNQVVDGSSYRVFEFPKNDANEGPRNLVTNPAEGTASPYGWHDTDGVPGPEYTITRGNNAHAYTDRDANNQVDPGSSPDGGPGLTFDFPADLDEHPQTYRDAAVVNQFYWCNIVHDLTYGYGFDEPSGNFQVNNYGRGGVGGDDVMCEAHDGSGQNNANFSTPAMDGGRPRMQMFLWPGNQFGLPNAVTVGSGAGAATYQAEYARFTPAPTRAGFAGDLALVNDGVGATGDGCTAYSMPAGAIAVLDRSSSCNYYTQVSNAEQAGAAAVVVVNNVAGAPVVMNGSMNPAVGIPAVMVSQADGNAIKAALPSAGRVHRNLDRPAMRDASFRAETIFHEYGHGVSLRLTGGPTVNCLTGNEQMGEGWSDFLAIVSLINPSIDNPEGPRGYGQYALFQDSRTGDGFRPRPYSRNMDIQPFTYDSIKTGGWLDGTSLAAPHGIGHGWAAVLWDMTWDLIDRHGFNPNVYDAWNTGGNNLALQLVMDGLKMQGCGPGFVTGRNAIIAADAALTGGENACSLWASFARRGLGYSAVQGTTGRDDNSEAFDTHPSCRGDFLNRTGMNTLDAGDAAPMQFQLASNRGLDILASNSPYSRLVDCDTLQTVNPSGPITPRPTPVKAVNPGNSKMSANANGRYNYVWKTDPAWAGTCREFVLTLDNGFQYRTYFKFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE30</accession>
    <name>F4FE30_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44899">
        <property type="protein sequence ID" value="AEB44899"/>
        <property type="gene ID" value="VAB18032_18985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18985"/>
    <dbReference type="eggNOG" id="COG3427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1767174_0_0_11"/>
    <dbReference type="OMA" id="QNGEETR"/>
    <dbReference type="OrthoDB" id="1929982at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="15931" checksum="406F12A29322744E" modified="2011-06-28" version="1">MDHVFTHLSDPHSYIGLSPLIVAVDDVRTSRDAEGRTVTDYVAVERFRFLRLLRWDNRIRVRMVTTRPGAQLVSDVVSPARVRLRAVVDLTAEETGTRVQERVTATAPALLRRFVTGQARQVAAYRAAELTRRMNDQAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEE9</accession>
    <name>F4FEE9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734867.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25585"/>
    <dbReference type="EnsemblBacteria" id="AEB46215">
        <property type="protein sequence ID" value="AEB46215"/>
        <property type="gene ID" value="VAB18032_25585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25585"/>
    <dbReference type="eggNOG" id="ENOG5031S54">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052996_0_0_11"/>
    <dbReference type="OMA" id="ATWAWSI"/>
    <dbReference type="OrthoDB" id="1464743at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="27327" checksum="1653C3B0718A3CE3" modified="2011-06-28" version="1">MEPLRRLWSAPEVPGRHDPQGPLGTRRTGGGFGVLPFIDEPAAPGPATNASWAWSLRRLARAAVWLLPAYAILYGLVAMASDGGVGNDPYPADGRALYLIGWVAAVWLGLLALLGLTGLLAATRSRHPAVAGLLVSIAGTVLMLPFAGLAEQTPVFGTTARTLVLVGATCYSLGWLLTGWAVARSGMFSIGDGTMLMIASPLLGLGGALIGSLQTFGAIFVLIAGIGIAYRSGRLMPREILNDAASASVATAGPPGPLGPGGAGPLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEF3</accession>
    <name>F4FEF3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_25605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25605"/>
    <dbReference type="EnsemblBacteria" id="AEB46219">
        <property type="protein sequence ID" value="AEB46219"/>
        <property type="gene ID" value="VAB18032_25605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25605"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_3_2_11"/>
    <dbReference type="OMA" id="LSFQNFF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="416" mass="44046" checksum="027EBF1624F57618" modified="2011-06-28" version="1">MRQAFQAGRESVRAARERQRERAAIRAEEARPDPLPWRPEPPVDGGGSTTSRDDSDVPKALRIAAAWSWRLIVIGVVGWALLRFMGAIRIVIVPLLVALLLTALLAPAVGWLLRLRVPRSLATAVVLISGLGAVVGTLTLVVNQFIVGLPDLSVRAAAGIGQIQDWLRDGPLGLSDGQLNGYVEAGQKWINENSQSLTSGAINTAGTVVEVFTGTLLVLFAMFFFLRDGDRIWRFLVGMLPVAARWRTDDAGRASWLTLVAYVRATVLVAFIDALGIGIALVLFDVPFAFPLAALVFLGAFIPIVGATLSGAVAVLVALVDSGWVTALAILGAVIVVQQVEGNVLQPWIMGRAVALHPLPVVLAVTAGVVLDGIVGALVAVPLIAVLNTAVRRLARRPPEPAPPIPDAVVVRSTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FER7</accession>
    <name>F4FER7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cdp-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731134.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06685"/>
    <dbReference type="EnsemblBacteria" id="AEB42461">
        <property type="protein sequence ID" value="AEB42461"/>
        <property type="gene ID" value="VAB18032_06685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06685"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025571_0_0_11"/>
    <dbReference type="OMA" id="FFRAAEY"/>
    <dbReference type="OrthoDB" id="786885at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045985">
        <property type="entry name" value="DUF5941"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19365">
        <property type="entry name" value="DUF5941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5941" evidence="3">
        <location>
            <begin position="342"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="664" mass="69319" checksum="491D81D7EB542AAA" modified="2011-06-28" version="1">MTLAIVLAAGSPAASLPAGDGTALVDRLAAQWRAAGVTDVRFAADLDELADLVGGSTGPVVVSGADLVAHTAVLRHLVTSPVGPTVALVLTDPPAGGRTTVREERGQVVDAGPAHRLDGEATGIFGGAVRVGRDDLPALVAAARAAATGRLADVAAGHGDGGPRVEPPGPAVDQLFTGLTAQGVLVFAQRVRLLVAHRVDDESGLSEARAAVAEVDEDRAELRLSVKEKDDFFTTYFVSTWSPYVTKAAARLGLSPTGVTMLSVAFAVAAAALFASGGRLALVTGGVLLYLGFVLDCVDGQLARYTRNFSAWGGWLDTMADRAKEYVVYAGLGWGATAAGVRYGWALAIAAMTLQTVRHMTDAWYGVLHDEAARRPKAVGTGGGGIGDRLNAASTKVQADTGSLSYWLKRTVVFPIGERWALIAVAAALFNQRIALLAVLAWGVLALAYTGALRTLRARWMWVPVLDTLDATLHRDDGPLAARFPVARRPGPLVLALLAVLPTILVLLATWRYGEAYPRWTVLLALVGLLLAAGGAGAAHNGPLDWLVPAALRAAEYLFAIAVGVIGQAPAWLIFGYVFVLTLHHYDLVARLEKRQPAPPLHAATLGWEGRSVLLAVAAIAGIASIGLATLGIYLLVLFVASVVLAWFVRPARVPAGAGRSTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEW9</accession>
    <name>F4FEW9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732349.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12835"/>
    <dbReference type="EnsemblBacteria" id="AEB43681">
        <property type="protein sequence ID" value="AEB43681"/>
        <property type="gene ID" value="VAB18032_12835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12835"/>
    <dbReference type="eggNOG" id="ENOG5031U0Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2753405_0_0_11"/>
    <dbReference type="OMA" id="CGCCGRW"/>
    <dbReference type="OrthoDB" id="2043768at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="70" mass="7933" checksum="80D869DF9EF74525" modified="2011-06-28" version="1">MSEWVCGCCGRWRVSVELIRGRHVYRLVHRYPRRFGGGDNVLGEVATVAELAALLRRWSPVDLADLHEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEX2</accession>
    <name>F4FEX2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_12850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732352.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12850"/>
    <dbReference type="EnsemblBacteria" id="AEB43684">
        <property type="protein sequence ID" value="AEB43684"/>
        <property type="gene ID" value="VAB18032_12850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12850"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311673_0_0_11"/>
    <dbReference type="OMA" id="CTISFWD"/>
    <dbReference type="OrthoDB" id="213863at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0270">Exopolysaccharide synthesis</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="7">
        <location>
            <begin position="14"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="5">
        <location>
            <begin position="206"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR1" evidence="8">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR2" evidence="6">
        <location>
            <begin position="666"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR3" evidence="9">
        <location>
            <begin position="817"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR4" evidence="10">
        <location>
            <begin position="892"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB43684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="948" mass="104244" checksum="4FA0FBCD1C7DB7F8" modified="2011-06-28" version="1">MKITFLLNTADALGGTERAILTQADYLARRHDVEVISVFRTSDTSFFAIDERVRRRYLVDLTGPTPRPHRATSVDDASYVALANSASRLIPKPWERQFNRLADLEVERALRSLDTDVLVSSSPALMSLATTLAPPGVVTVHQEHRPSQLRGGTGQPLFQMSPRLDALVVLTDRTRDWFVDTFGTSCPRLEVIPNSIPDGYRPRSDLRNPVVAIAGRMVPEKRIDHAIRAFGKVAAAHPDWTLRVYGDGPLLPEMRRLASDLGLHDNVQVLGATDRMTEEWSKASVALLSSRDGEALPLVLLEAFAAGVPAVSYDIQTGPAEIITHGVDGLLVSSGDEDQLAQALIRLVADDELRRSFGANALVAAERYRIGPIMQRWENLFAELVAEHAGTEQLRADRLATWLARAGGSGFAPAAPRPSHVATGPDLESLEQQVDEAVPGLVRSGGRLSVVADDLTPADAAYANFTAVVDVLERSGIPYWVARDPGVRHRVVVALEQQEATLSALAAAFAKAPYYVETLTTDAKVTGVTLAACLATEPRAADARGLRVFRPIVSTSRTLRYGPALGCDVEFWVPSAEGDALIATRRTLLGNSVPVAAMAPAVLTVRDRQHPTIEPFTQRLVSEVDFPVDVVYTWVDGSDPTWVADKNSLLASLGRAPVEAAGSTARFRDREELRYSLRSIDMYAPWVRNIYLVTAGQSPSWLDTDHPRITVVDHRDLFGSRGALPTFNSHAIESQLHHIDGLAEHFLYFNDDFFLGRPVGPTLFFRSNGLSQFFLSPTSIPMLEVSADDDFNFSAAKNNRRLIRQAFDATLTHGLLHAPYAMRRSVAYDLDKAFACEIDRTAASRLRDHADVSVASSLHHYYGYLTGRSVQGGIRVSYVNTGDPSEHPQLTQILITRGYDAFCLNDTHHGQLDEAEQNRIVAGFLESYFPVASQFERGSRRNRAHRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEZ5</accession>
    <name>F4FEZ5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732375.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12965"/>
    <dbReference type="EnsemblBacteria" id="AEB43707">
        <property type="protein sequence ID" value="AEB43707"/>
        <property type="gene ID" value="VAB18032_12965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12965"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050048_0_0_11"/>
    <dbReference type="OMA" id="GHLLWDG"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="189"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="37672" checksum="9F2821E0EE94437C" modified="2011-06-28" version="1">MTLWRIRATVDDRPGYLSVLTASLALRGVNILTVQVHTTEHGAVDDFLVDAPDTLDEADLVAAVERGRGRDCWVARSEARGLVDQPTRVLALATRLVRDPDATGEVLRALLGADEVTWRPASEAARCGIDGLTMLLADPNGGAYHLRRVAPSFTPAEYARAQALLELGATAAGRGADQITVVLPDGAELTVRPAVAEDLTAVAELHEACSARTRQRRYLGGAALPTPARLRRLLEPTRGLTLVAVTNDADPSTESVVAMANLLAEGDEAELALLVRDDWQRRGLGSMLLRRLVRQAESSGYAATVLHTQADNTPMLRTLRRLHRPTTIEQDGGLLTVTMPLVAEVPVESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF06</accession>
    <name>F4FF06_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732386.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13020"/>
    <dbReference type="EnsemblBacteria" id="AEB43718">
        <property type="protein sequence ID" value="AEB43718"/>
        <property type="gene ID" value="VAB18032_13020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13020"/>
    <dbReference type="eggNOG" id="COG1576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051661_1_0_11"/>
    <dbReference type="OMA" id="VIEEQQW"/>
    <dbReference type="OrthoDB" id="1805421at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="191" mass="20681" checksum="860BE5163F209E64" modified="2011-06-28" version="1">MDLLETYRRSVAEFADRVPLVAPGQWSAPTPCADWDVRTLVNHVVGEDRWSVALLAGRTIAEVGDRYDGDQLGADPVEAARDAAAQAELAATRPGVRDATVHLSAGDTPAEEYLRQLIAEHLVHGWDLAVAIGADPKLDAEAVAECARWFAGEVDAYRNNGLVRAEVDVPTEADEQDRLIAAFGRDPDWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF20</accession>
    <name>F4FF20_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732400.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13090"/>
    <dbReference type="EnsemblBacteria" id="AEB43732">
        <property type="protein sequence ID" value="AEB43732"/>
        <property type="gene ID" value="VAB18032_13090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13090"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051479_2_0_11"/>
    <dbReference type="OMA" id="SHNTQCW"/>
    <dbReference type="OrthoDB" id="1079953at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="35333" checksum="2B99EC4F51A2BBC8" modified="2011-06-28" version="1">MDIGYSVEQLRVAATDAVRAPSLHNVQPWRFRLRDGGIEILVDPARRLPATDPSGWGARVAAGAALFNLRLALAVAGHPATVRLRPYPAEPDVVARLMPDVPRRPTPTEQSLYAAIPRRFSNRAPFWPDPVPADARWRLSDAARAEHCWLELLIGVSAVNAFAEIANGANRVLERDPAYRAERQAWIRREHALDGVPTAAGGPRAEPQDLLPARGFGDRCRPPGRDFEPEPLVAVLGSTGNTAVDQVVAGQALQRVLLTATDCGLSVSMLSQPVEVPSAREQLRVSLGRFGAPQMVMRIGYGQPGWPTPRRDVDEVLDLPVHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF24</accession>
    <name>F4FF24_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13110"/>
    <dbReference type="EnsemblBacteria" id="AEB43736">
        <property type="protein sequence ID" value="AEB43736"/>
        <property type="gene ID" value="VAB18032_13110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13110"/>
    <dbReference type="HOGENOM" id="CLU_2605096_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="8953" checksum="3146E329A3CDE9DA" modified="2011-06-28" version="1">MVNGRRVAGVWWLIVTTFPYVPIVPYLGTAVGRVPFILGQTAAVRTDRWARRRGHSGPDPAVRRRTQPADLARVVCRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF60</accession>
    <name>F4FF60_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19315"/>
    <dbReference type="EnsemblBacteria" id="AEB44965">
        <property type="protein sequence ID" value="AEB44965"/>
        <property type="gene ID" value="VAB18032_19315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19315"/>
    <dbReference type="eggNOG" id="ENOG5032BPY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314944_0_0_11"/>
    <dbReference type="OMA" id="NRWAYLR"/>
    <dbReference type="OrthoDB" id="2031639at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="21780" checksum="01BB1C9B494954D1" modified="2011-06-28" version="1">MALTSVAATVYGVASASENDTPTPSAVAVDAPAAAAPVAGLRPPGAGKGRPTPQPTPSIDAVLSGKRRVTIVRVGAFEGGLSLLDGGRLAEVDDDRGRQVFVPTPLGSGEFLMKAYYGGGTGKPICWQAHNPQNTQPLYVRGATCRANDPAQRFVITAAEGGGPREYVISNRWAYLRDSVRSGLILEELGDAAPFSSFRFNDTGPAPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF66</accession>
    <name>F4FF66_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19345"/>
    <dbReference type="EnsemblBacteria" id="AEB44971">
        <property type="protein sequence ID" value="AEB44971"/>
        <property type="gene ID" value="VAB18032_19345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19345"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_4_0_11"/>
    <dbReference type="OMA" id="GYRVYAD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="16334" checksum="05E5A28F9733550C" modified="2011-06-28" version="1">MRIGELSARTGASERMLRYYEEQGLLKPERTASGYRVYADADVDRVARIRCMLSASLPSGVVGQALRFLLDGRAAIPDEPADRARLAETLESELDQLTEKIASLQHSRELLATFVADVRGDAVGPGRPGDPGARVVRRSVSKAGPATGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF79</accession>
    <name>F4FF79_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PfkB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_19410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19410"/>
    <dbReference type="EnsemblBacteria" id="AEB44984">
        <property type="protein sequence ID" value="AEB44984"/>
        <property type="gene ID" value="VAB18032_19410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19410"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_2_11"/>
    <dbReference type="OMA" id="NWRPTFW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="32967" checksum="F916FCCD69AE02AD" modified="2011-06-28" version="1">MTCDPQPVVTVLGEAVVDLVQGPDGRFTAHPGGSPLNVAVGLARLGVPATLLARFSTSRFGRILRAHADANGVDLRHAVDTDDPATLAIASLDDDGVATYDFYVDGTADWQWRDDELSPALTSRGILHTGSLAVFRSPGADRVADALRTARAERALISIDPNIRPGLLGTPAQARARVEELIRLAHLVKASEEDIAWLYPGRPVEDVLRHWRDLGAALTVVTLGAGGALALSGTRTFRQPAPAVEVVDTIGAGDAFTAGLLAALSRAASGWPNEEIAAALRYAVEVAAVTCTRAGADPPYRHELSNPDQPGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF93</accession>
    <name>F4FF93_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_19480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733653.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19480"/>
    <dbReference type="EnsemblBacteria" id="AEB44998">
        <property type="protein sequence ID" value="AEB44998"/>
        <property type="gene ID" value="VAB18032_19480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19480"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_11"/>
    <dbReference type="OMA" id="RSAACKV"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="9"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="341" mass="35918" checksum="74E39470F9BAB4FC" modified="2011-06-28" version="1">MNRSAYYVGDQTFVVKEADPVPPGPGQVRIEVAYTGICGTDLHIAHGAMDQRVQRPAVIGHEMSGRIAELGAGVEGHRVGDPVTVMPLDWCGDCPACRAGHTHICHRLNFVGIDSPGAMQQSWTVPARILVPLPEGLSLAHAALVEPTAVAVHDVRRSRLAAGEHAVVIGAGPVGLLIGTVARTTGAQVTVLELDPRRRQLAADLGLSAVDPATVDVAGYVHEVTGGAGAEVVYEVSGSAAGVRTATDLLAVRGRLVVVAIHPAPREVDLHRIFWRELEVIGVRVYERADYVEAVRLVHGGQVPVDRLISRIVPLTEVAQAFEALATGGDVKVLIDCGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFE0</accession>
    <name>F4FFE0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_25720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734894.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25720"/>
    <dbReference type="MEROPS" id="M24.033"/>
    <dbReference type="EnsemblBacteria" id="AEB46242">
        <property type="protein sequence ID" value="AEB46242"/>
        <property type="gene ID" value="VAB18032_25720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25720"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_0_11"/>
    <dbReference type="OMA" id="YRRWTLH"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="4">
        <location>
            <begin position="46"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="493" mass="54352" checksum="E20268A8E78ED7AF" modified="2011-06-28" version="1">MTEERTDGKPADGTESHDPDFPPAFLAFMRQGWRDTTLPVGPRPEVPNYAKRRAALSAAFPGETLVIPTGGEKIRANDTEYRFRPGSDFAYLTGDQDPDSVLVMRPNGSGHDAILYMRPRSSRENDEFFRSRHGELWVGRRHTLTEKSTELGLPTVDLTELDGALADLAPARTRVLRGFDPRVDAAVRAYDGAREEGQPARDRELAIAISEQKLVKDEWEIGQLQEAIDATVRGFEDVARVLPADRGVSERLLEGIFALRARHDGNDVGYGSIVGAGEHATILHWVHNHGVTRPGELLLMDMGVEGRNLYTADVTRVLPVNGRFTALQRQVYDIVYASQQAGIDAIKPGVAFKEVHLTCMRVLAEGLADLGLLPVSVDEAMDETSTVYRRWTLHGFGHMLGIDVHDCSNARKEAYRDGSLGEGYVLTVEPGLYFQPEDDLVPEELRGIGIRIEDDILVTSSGAVNLSAGLPRRSDEVETWLAAQREAGPRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFH3</accession>
    <name>F4FFH3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_25885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734926.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25885"/>
    <dbReference type="EnsemblBacteria" id="AEB46275">
        <property type="protein sequence ID" value="AEB46275"/>
        <property type="gene ID" value="VAB18032_25885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25885"/>
    <dbReference type="eggNOG" id="COG2321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059329_1_0_11"/>
    <dbReference type="OMA" id="QKRSQGY"/>
    <dbReference type="OrthoDB" id="1175086at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="301" mass="32240" checksum="CEE8260BFD0B019E" modified="2011-06-28" version="1">MELNENARIDTSQIDDRRGSGGGGGMGIPIPIGGGRGGIVGIVIAVLVALVGGGLGLNAMTGEEGDNAALEQRCEEAPDALEHLDCRNNLYVNSIQAYWRTALPEAFGEQYRPTRTVFFDRAVNTACGSADSGVGPFYCPADSLVYIDLSFYEVLSEQLGASGEFAQPYVLAHEYGHHVQNLLGTNEQVRRAQQRDPGAANELSVRLELQADCYAGAWAKNATGTADDRGQKIFTSITERDIAEAIDTAEAIGDDAISERANRPVNPDEFTHGSSADRKRWFNRGYESGDPATCDTFSGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFJ5</accession>
    <name>F4FFJ5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ordered locus">VAB18032_25995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734948.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25995"/>
    <dbReference type="EnsemblBacteria" id="AEB46297">
        <property type="protein sequence ID" value="AEB46297"/>
        <property type="gene ID" value="VAB18032_25995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25995"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_1_0_11"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="254" mass="26569" checksum="3022A15D4407DDAD" modified="2011-06-28" version="1">MSEASVAVHADADLLAQAVAARLVVKLLDAQAERGQAAVVLTGGRIAAAVYRAVGALPAKDAVDWSRVDFWWGDERFLPAGDPERNETQARAALLDALPVAPERIHPMPPSDAGLDPEEAAAQYAAELARAARPGTALLPHFDVLMLGVGEDGHVASVFPEHPVHYESRPVSAVRGSPKPPPVRITLTLPTINTAEEVWLVAGGADKAHAVGMALAGAGPVQIPAAGVQGTSRTLWLLDRAAAATVPARFRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFV6</accession>
    <name>F4FFV6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731209.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07060"/>
    <dbReference type="EnsemblBacteria" id="AEB42536">
        <property type="protein sequence ID" value="AEB42536"/>
        <property type="gene ID" value="VAB18032_07060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07060"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_0_2_11"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="399" mass="44167" checksum="145A09916E055960" modified="2011-06-28" version="1">MTAVRAPRVSFDVSDPRLLADPFPTYEQLRRTGAVLSNGPGQWVVPGYREVAALLKDQRLTKTLPEQYYRFTVGDPELSGFLSGQNLGQRNRLASRVLVSSFSPGLVRRLGERMTSLVDDLLEPVLATGRMDLVADLALPFPLMVICDLLGVPAADRSLLWPHAAQLVRAFSDVAFGNDRDIDEAVRSLRWLREYLGDLVENGPAGDNLLTRMATTESDGQRLRREEIVDNAITVFYAGFETSMGMITNGMVALLEHPDQLARLRAGTAGTATAIEEMLRYEAPIQVTMRSPLEPVEVADRVIRPGRVLYLLVGSANRDPEQFDEPDLFDVGRRPNQHLSFGAGVYHCLGAALARAEGVAVFGRLLGRTRAIELDGEPVRRPRFNFRTYDQVPLAVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFW2</accession>
    <name>F4FFW2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_07090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07090"/>
    <dbReference type="EnsemblBacteria" id="AEB42542">
        <property type="protein sequence ID" value="AEB42542"/>
        <property type="gene ID" value="VAB18032_07090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07090"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_11"/>
    <dbReference type="OMA" id="AWPHIQG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="2"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="422" mass="44253" checksum="03E04570ED4D9AEE" modified="2011-06-28" version="1">MLHRIGDLILENADRLALLDCLDNGKPLRVARAGDVPAAAAVFHYMAGWPGRLNGENASIYTGSPERHLALTVPEPVGVVAAIIPWNFPLYMAAAKVAPALAAGCTVVLKPAEQTPLSALALAQLAQEAGLPPGVLNVLTGDAATGAALAAHPGVDKVTFTGSTEVGRSIVRGAAVDFRRVTLELGGKSPNIVFGDADLRQAIDGAAHAIFYNQGETCVAGSRLYVQRQVFDEVVAGIRERAAAIRIGDGLDRDTEMGPLISAEHRTRVLSYLDSARADGARVTGGQVPDSPGFFCTPAVVTDADPQAPVVREEVFGPVLVAQPFDTVQEAVALANDSPYGLAAGVFTRDLGLAHQVGRRLRAGTVWINSWHVLDPALPFGGMRGSGWGREMGKAGVDAFLETKTLINDLGNRSWGPTPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFY1</accession>
    <name>F4FFY1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731234.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07185"/>
    <dbReference type="EnsemblBacteria" id="AEB42561">
        <property type="protein sequence ID" value="AEB42561"/>
        <property type="gene ID" value="VAB18032_07185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07185"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848953_0_0_11"/>
    <dbReference type="OMA" id="PYFYCHF"/>
    <dbReference type="OrthoDB" id="1229914at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="312" mass="34584" checksum="1482FEB85E6098EA" modified="2011-06-28" version="1">MTTLVPPTPVPSVLVGRPRYEGANIRTWIGFKHFMYLVEEAVLQWLRDQGHGARELFHQYGLGTEIVDCSVQLPAVLEVDDEVRAEVVAGTGKRLRVQMSVHRDGQDVVVLRGHVTVALIPETDAPTHRTAPDTLAAWEAAELGEATGLRSERTLPAGADLASTLAPAGSGAFLWSWRAPYFYCHFSDRVQHSGYVRALEEVVDRFLADRGISVGRMLRERAWIPVVSRARVRLAEPAHMEETVHTVFQVDDVLREMMFSGRMDCWVQRDDRLIQVASATILHGYAISRGPDAGQLARLDPEVCAILTGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG42</accession>
    <name>F4FG42_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13370"/>
    <dbReference type="EnsemblBacteria" id="AEB43786">
        <property type="protein sequence ID" value="AEB43786"/>
        <property type="gene ID" value="VAB18032_13370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13370"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778262_0_0_11"/>
    <dbReference type="OMA" id="TVLQRCC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="195"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="37545" checksum="BF8BAA72486EA6C1" modified="2011-06-28" version="1">MCSTRPGALGPVVGQWLIETLTPRAAELGVELVPVAIGDLNLPFLDEEGHPSSGDYRHEHTRRWSETVDAADAFIAITPEYNYGMPATLKNALDYLSREWAWKPIGFVSYGHTSAGTRAVQHAKQVVTTLRLVPLGATVAIRIGAAMQDGRLRPDAAHHAAGVGLLEELVRVAHALRPMRERAHVGSCAGPLPGSYARRLTADDVGQVTVLQRCCWVDEALANDTMDIPALHESPEQVREWLTSWHATGLWRDGRLLGMVRSRRVDTDWHVGRLAVAPDLRGQGLGRWLLRTAEAAADPDCRRIVLFTGARSQRNIDLYHSEGYRPVSLASPDGTTCLTKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG74</accession>
    <name>F4FG74_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732485.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13530"/>
    <dbReference type="EnsemblBacteria" id="AEB43818">
        <property type="protein sequence ID" value="AEB43818"/>
        <property type="gene ID" value="VAB18032_13530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13530"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518421_0_0_11"/>
    <dbReference type="OMA" id="WALELYQ"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="402"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="527" mass="56587" checksum="3EA9872D3D10A2F4" modified="2011-06-28" version="1">MDEVTLGALRLLEEAQAGGAAQVLTAAESALREPTGQIGDGPAAMHFARVVALTRLGDLRAAIDAADLMLAAADREGSAGWRSCALSLRATRRLRLGGQDLAEYDIEAVLRDLVSAETALLADEPNPVITGNAHTGIAIGYAQLRLYELAAPQFEAAYQATRHASYPDNGNRAMWLCNLAELNLIWALELYQVGRIAEAERHTTAAEEYAMRAVAEASGPKAEVWRLSALLYAACSRADRQDPAAAAVDIPRYTNLLRVHGLPEQHQEILLCRPFHAVALRRSGRPEEALRVIEEAVALLSPETDCLISAAVHRTHAVLLAATGSAGARPGLTYGDTLAELLWRQRHHWLHTAMTMQAYDALRWQHEQAERAAQTDPLTGVANRRGLDRFLRALAHPDAADHPVAVLAVDIDRFKHINDSLGHSTGDDVLRAVAQLLTTSVRQGDFVARLGGDEFVAILPGADATLARLVAQRTVEAVAGLTAWPAQVSVGVAYGPAYCLEQALSHADSAMYAAKRAGGNRASCLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG88</accession>
    <name>F4FG88_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_19620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733681.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19620"/>
    <dbReference type="EnsemblBacteria" id="AEB45026">
        <property type="protein sequence ID" value="AEB45026"/>
        <property type="gene ID" value="VAB18032_19620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19620"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016513_0_0_11"/>
    <dbReference type="OMA" id="GNVQCLD"/>
    <dbReference type="OrthoDB" id="433393at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="175"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="279"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="542" mass="58554" checksum="8300A8C78C951E7A" modified="2011-06-28" version="1">MTTHEVSNQVPPLIDHDTADDPALLEGLAREGAGWAVGEVRDLGRLAGSQPAIEHGRLANEYPPVLRTHDRYGHRIDEVEFHPSWHELMRTAVEHGLHAAPWADERVGAHVARAAKFYTWRPDAGHGCPISMTYAAVPALRHAPDLAADHEPLLTTRAYDFGLRPPLTKRGLLAGMSMTEKQGGSDVRANATTARPQPDGSYRLVGHKWFTSAPMCDLFLTLAQAPGGLTCFLVPRVLPDGTRNPMRLMRLKDKLGNRSNASAEVEYEQAAAWRIGDEGRGVRTIIDMVNLTRLDCVIGAAAGMRQGVITAVHHATHRRAFGRALIDQPLMRNVLADLAIESEAATILMMRLAGATDRAARGDATEAAFKRIALAIGKYWVCKRWPGHAAEALECLGGNGYVEESGMPRLFRESPLNSIWEGSGNVAALDVLRALAGQPEVLAAFRAELDAAAGADPRLDAAVRQVQAALADPADREVRARRLVEQLALVLQGALLVRHGHPAVADAFCASRLAADHGHAYGTLPPGVDFPTLLARATPKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGC6</accession>
    <name>F4FGC6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733719.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19810"/>
    <dbReference type="EnsemblBacteria" id="AEB45064">
        <property type="protein sequence ID" value="AEB45064"/>
        <property type="gene ID" value="VAB18032_19810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19810"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099730_0_0_11"/>
    <dbReference type="OMA" id="TVIHHVP"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="243" mass="25984" checksum="2122338EA5FED024" modified="2011-06-28" version="1">MARIAYNAADAAAFKANRHVTEDSLAAWQAAVIRHLDPQPGMRVLDLGSGTGSWARAFTTWLPDAEIVAVEPSAAMRDHSVFAPVLAGDAAHIPLPDGSVDAVWLSTVIHHIPDLPAAAHELRRVLRPGASVLIRSGFAGRPERISLFRYFPEAIAVLDTFPSIADVEAAFGAADFTLVAVEQIPELTATSLGEVVASLRREAHTLLQLIDDDAYAAGLRRLHQAAQVDSGPVIDALDLLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGG8</accession>
    <name>F4FGG8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">whiA</name>
        <name evidence="8" type="ordered locus">VAB18032_26025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734954.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26025"/>
    <dbReference type="EnsemblBacteria" id="AEB46303">
        <property type="protein sequence ID" value="AEB46303"/>
        <property type="gene ID" value="VAB18032_26025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26025"/>
    <dbReference type="eggNOG" id="COG1481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053282_0_0_11"/>
    <dbReference type="OMA" id="CDAEAAW"/>
    <dbReference type="OrthoDB" id="1634356at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="6">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="7">
        <location>
            <begin position="128"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="34843" checksum="77F98436CF7C9F15" modified="2011-06-28" version="1">MAMTAAVKDELSRVDVPKPCCRRAEMAALLRFAGGLHIVSGRVVVEAELDTGAVARRLRREIAEVYGYPSEIHVLASGGLRKGSHFIVRVVKDGEALARQTGLLDVRGRPVRGLPPHVVAANVCCAVSAWRGAFMAHGSLTEPGRSSALEITCPGPESALALVGAARRIGITAKNREVRGVDRVVVKDGDAIAALLTRIGAHASVLAWEERRVRREVRATANRLANFDDANLRRSARAAVAAAARVTRALEILADDAPEHLTSAGRLRLEHRQASLEELGALADPPLTKDAIAGRIRRLLALADKRARDLGIPDTEAAVTPDMLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGJ0</accession>
    <name>F4FGJ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734976.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26135"/>
    <dbReference type="EnsemblBacteria" id="AEB46325">
        <property type="protein sequence ID" value="AEB46325"/>
        <property type="gene ID" value="VAB18032_26135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26135"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_1_0_11"/>
    <dbReference type="OMA" id="RMNGEIN"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="172" mass="19557" checksum="AE7A0651655143D3" modified="2011-06-28" version="1">MYRRRDTRREMLVAEITAELRRYCVDAQHVGHAFAGQHGLNGTDLQALIAVMDAELSGEPITPGRLAEHLDLSSGSVTALIDRLERAGHLRRDRDTTDRRKVLLHYAEQGATVARDFFRPLGERTDGVMDEFQDEELEIVYRFITAMGQSLREHRDAIRDGRVTPPPRHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGK1</accession>
    <name>F4FGK1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="3">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">coaE</name>
        <name evidence="4" type="ordered locus">VAB18032_26190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CoaE family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the UPF0157 (GrpB) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734987.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26190"/>
    <dbReference type="EnsemblBacteria" id="AEB46336">
        <property type="protein sequence ID" value="AEB46336"/>
        <property type="gene ID" value="VAB18032_26190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26190"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067032_0_0_11"/>
    <dbReference type="OMA" id="IRVDGWP"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="42815" checksum="2FACAF4C582226E7" modified="2011-06-28" version="1">MLKVGLTGGIGSGKSAVARRLVERGAVLVDADQISREVVAPGTDGLTEVVAAFSARVLDADGALDRAALADLVFTDEAARRRLEAIVHRRVRARTAELIAAAAPDAVVVNDVPLLAEVGLAPTYHVVVVVQTALATRLQRLTRDRGMSRADAERRIAGQADDASRAAVADVLLSNDGTLAQLHAAVDALWDDRLVPYEENVRHRRAVRAQRVTLTEPDPTWPQQYARLAARIRHAIAPAELRIDHIGSTAVPELAAKDVIDIQLGVPSLAEADGPLAQRLADAGFPRMPGDWWDTPRPAGTGRWEKRLHGSADPARPVHLHLRVTGSLGWRYALLMRDHLRADPDRRAAYLMLKRELAASAPDSGTYATAKDPWFDEEHLRAEEWAARTGWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGN6</accession>
    <name>F4FGN6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_26365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26365"/>
    <dbReference type="EnsemblBacteria" id="AEB46371">
        <property type="protein sequence ID" value="AEB46371"/>
        <property type="gene ID" value="VAB18032_26365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26365"/>
    <dbReference type="HOGENOM" id="CLU_3376621_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="34" mass="3365" checksum="8927CEAD288CE312" modified="2011-06-28" version="1">MLDGAGAPAAAARNGGLVLLRGAMAISANAWPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGW2</accession>
    <name>F4FGW2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02690"/>
    <dbReference type="EnsemblBacteria" id="AEB47622">
        <property type="protein sequence ID" value="AEB47622"/>
        <property type="gene ID" value="VAB18032_02690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02690"/>
    <dbReference type="eggNOG" id="ENOG5032RKK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139818_0_0_11"/>
    <dbReference type="OMA" id="PIREWAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="116" mass="12471" checksum="B4309BCB3E88AF54" modified="2011-06-28" version="1">MAKQIIHKLVDDLDGGDADETVKFALDGVQYEIDLSSSNADKLRDAFAQYIAHGTKVGRGGVVVGGRAARGRGGATADREQNKAIRAWARKAGKDISDRGRIPQEIVDEYHAKAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH23</accession>
    <name>F4FH23_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731310.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07585"/>
    <dbReference type="EnsemblBacteria" id="AEB42637">
        <property type="protein sequence ID" value="AEB42637"/>
        <property type="gene ID" value="VAB18032_07585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07585"/>
    <dbReference type="eggNOG" id="ENOG5032XQ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803964_0_0_11"/>
    <dbReference type="OMA" id="YRIWINA"/>
    <dbReference type="OrthoDB" id="1712449at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="345" mass="37716" checksum="DAF9ED6A817DA2DC" modified="2011-06-28" version="1">MNFLPNDTLAGYARTAVDLRTRMVDYHRGPLAAQYLQAFFGGRLADHPSPSPAGMAKVLDAARAITANPWRSGEPYVIAPAMTAIIAAAAAALDLTGEVLPADVAPTDGGVLFLPEPIYHRSHSGEVSSLGAITWARTTSTGSGRSAWAIGGWADHHDPHDPSAIRRREQLAARPDLARQFGPYVLTDFTEIPIGQPVDPRPDLPVLDGDDRDWEPAPDGRFCIDETTTAMRACAAVAYAFWRIQAQPLATVAAAPLDRAARRRAVRASIRHDTRVVMLRRTSPLAEPADGEPKWHYRVRFVVRGHWRRLIDRAGNPYRIWINAHIKGPDGAPLLHGEKVAVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHG1</accession>
    <name>F4FHG1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group 1 glycosyl transferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20165"/>
    <dbReference type="EnsemblBacteria" id="AEB45133">
        <property type="protein sequence ID" value="AEB45133"/>
        <property type="gene ID" value="VAB18032_20165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20165"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_16_0_11"/>
    <dbReference type="OMA" id="YAETYGM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="159"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="341" mass="35948" checksum="E135A23A24BFC909" modified="2011-06-28" version="1">MHVILPGDIDDPATPSGGNGYDRRICAGLAAAGWSVREHPVPGAWPTPSPAEHARLAELLTALPDGALVLVDGLVASVVPDALAAQARRLRLVPLVHLPRDDDTEARALASATVIVATSTWTRDRLLHRYALPPSLVHVAAPGVDPAPRVTGSPAGAALLCVAAVAAHKGHDLLVEALAAVTDRDWTLTCVGPLHREPDFVDRLRTQITTHRLDDRIRLAGPLSGDLLAAAYAGADLLVHPSRGETYGMVVTEALARGIPVLATAVGGLPDALGHVAGERPGVLVPPEQPAALADALRRWLDDASLRARLRRIAARRRTTLDDWTSTTTRITTALEEAMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHJ0</accession>
    <name>F4FHJ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20310"/>
    <dbReference type="EnsemblBacteria" id="AEB45162">
        <property type="protein sequence ID" value="AEB45162"/>
        <property type="gene ID" value="VAB18032_20310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20310"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058777_0_0_11"/>
    <dbReference type="OMA" id="FQLADWT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="29256" checksum="FBD7CEE5538E1344" modified="2011-06-28" version="1">MTSDRAALRRFSLNQATTKHWPLPDVVAGCVAAGVPGIGLWREPVAEYGLARTATLVRDAGLAVTTLCRGGFFTADDWREENLRAIEEAATLGAPVLVLVCGGLPEGSRDIDGARARVADAIADLAPHAEAAGVRLAIEPLHPMFTADRCVIATLGQALDIAERFDPDVVGVVVDAYHVWWDDTVYAQIVRAGERIASFQVCDWITPLPEGVLLGRALPGDGCIELRRLREAVDRAGYTGPIEVEVFHADVWARPGEQVLAASIDGYLREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHM1</accession>
    <name>F4FHM1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase fad-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735041.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26566"/>
    <dbReference type="EnsemblBacteria" id="AEB46390">
        <property type="protein sequence ID" value="AEB46390"/>
        <property type="gene ID" value="VAB18032_26566"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26566"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_11"/>
    <dbReference type="OMA" id="EPQATRW"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="41517" checksum="76E135DFACEB8108" modified="2011-06-28" version="1">MRTAVVVGGGLGGLAVSGALARSGWQVTLLEQADRIRPEPTAVVLWPNGVRALRALDLGAGLDAVATALPDGGVRRPDGHWLVQPRPVPVERLPVVVHREDLHDALIAGLGDRVELRTGVTVRTVRAAPGARPAVGDGRHLYEADLVVAADGVDSVIRRQLAPGANVVSSGCAAWRAVIPWYRAPNLSESVSGEILGAGYRFVAASLGERGSSGASSRGGIYWMATAAGAARPEPPQTQLALLRRWYAGWPGPVEELLAATEPDDLVQQEIRELRPLPKAYGFPLGPGGVVLLGDAAHAMPPHLGQGACLAFEDAATLAALLRESTLPDAVLAYDRARRPRAAAVVRQTRRMSAVLQTRGRLALRARDVALNTITPRILGTAATVAAQWRPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F159</accession>
    <name>F4F159_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731386.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07975"/>
    <dbReference type="EnsemblBacteria" id="AEB42713">
        <property type="protein sequence ID" value="AEB42713"/>
        <property type="gene ID" value="VAB18032_07975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07975"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137403_0_0_11"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="201" mass="21570" checksum="EDD344A53556AB7E" modified="2011-06-28" version="1">MSFILDHLDEIEATVPGLAGRLDRERVAVAGHSLGGHTAAMLLGTGTTDPADGSPVRLPDARIKAGVIIGAPGLADEQVNQAMLERYPVMGHTDFSTMTTPALVVAGDRDFNPMFSDRLSYRWDAYTAAPAPKTLLMLHDAEHLFGGISGYDAAETSDENPARVAVLRAMIWAYLRSQLYPTDPAWDRAVAAFDSGSVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F164</accession>
    <name>F4F164_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08000"/>
    <dbReference type="EnsemblBacteria" id="AEB42718">
        <property type="protein sequence ID" value="AEB42718"/>
        <property type="gene ID" value="VAB18032_08000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08000"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021898_1_0_11"/>
    <dbReference type="OMA" id="FAGMSMQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="543"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="635" mass="67749" checksum="A554752F97007759" modified="2011-06-28" version="1">MAVALLVLVGQLLQRDPLLFGPSTLTAVFAAAFTALGALVLAGVPGHPVGRLMLAAGLVATVAVLALSWSSWLPLAWLGQWLWWPPYTLVILALLVFPDGKLPGPRWRVVAAGLIGAGGLTTGAFAVAALDDPRGLLLTGELAATGRAQLWVRVALLAIVVQVLLVVAVLVSLAGRWHRATGQTRQQLACLLVAGALFLLGGVLDALNLAGAWALMVVAIPGAMTLAVLRYRLYQLERVINRTLVWLVMSLLVIAGFVAIVALLRDLVVGPDTSNASLVATGLIAITFEPLRGRVQRGVNRLLYGDRDDPYAMLTRLGSLLERTGQPHAVPALLADTIARSLRVPYVSVEVDDADGGDLPDGGAAHGTPTTSVERFDMLIHGDRVGQLVVAHRRTGDRFTPMERRILTDVARQATAAVATARLIRQLRQAREGLVLAREEERRRLRRDLHDGLGPTFAGMSMQVRAASKLATGTPRLELILDRLADDLRTCTAEVRRLVDQLRPAALDQGLESALRAECRRFDGPQLGIDLTVDGDLRTLPAAVEVAAYRIVAEALSNVVRHAHASRCEVRVSRGDALLVEVADDGVGLAGPRPGGVGLDSFHHRAAELGGSCEITAGAQGGTLVRVRLPWVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F174</accession>
    <name>F4F174_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731401.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08050"/>
    <dbReference type="EnsemblBacteria" id="AEB42728">
        <property type="protein sequence ID" value="AEB42728"/>
        <property type="gene ID" value="VAB18032_08050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08050"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_0_0_11"/>
    <dbReference type="OMA" id="DPGHDFG"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="30494" checksum="C305F8C23A637A27" modified="2011-06-28" version="1">MSGVLRLGGRTFDPDELVVMAIVNRTPDSFFDRGATFAADSALRAVERAVDEGAEIVDIGGVKAGPGAEVDVAEEIRRTVDTIAAVRAAFPDVVISIDTWRAEVAVEAVAAGADLLNDTWSGADPALAQVAARTGAGLVCSHAGGLSPRTRPHRAAFADVVTDVVTTVTGLAERAVSLGVRRDGILIDPAHDFGKNTRHSLEITRRLGELTATGWPLLVALSNKDFVGETLDLPVDERLEGTLAATAVSAWLGARVFRAHQVRPTRRVLDMVASIRGNRPPAVSRRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1A9</accession>
    <name>F4F1A9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732612.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14165"/>
    <dbReference type="EnsemblBacteria" id="AEB43945">
        <property type="protein sequence ID" value="AEB43945"/>
        <property type="gene ID" value="VAB18032_14165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14165"/>
    <dbReference type="eggNOG" id="ENOG503315W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="RTEWRTS"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="66" mass="6982" checksum="BB9AF2793B61EAA7" modified="2011-06-28" version="1">MTALDLSRAKWRTSTRSVGNGNCVEVATLDGHVAVRDSKDRGGPVLTFPPSAWTAFVGGLHDADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1C1</accession>
    <name>F4F1C1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_14225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14225"/>
    <dbReference type="EnsemblBacteria" id="AEB43957">
        <property type="protein sequence ID" value="AEB43957"/>
        <property type="gene ID" value="VAB18032_14225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14225"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079569_3_1_11"/>
    <dbReference type="OMA" id="SIHFVIA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="207" mass="22003" checksum="14B3659687297492" modified="2011-06-28" version="1">MLIDPGLLAVFLVAVLVICVTPGPDMLYILATSVSQGIRAGLVASVGMSLGMLVHTVLVSLGLAALMAAVPVLFDVIKYVGAAYLVYIGVRAWLDSSSASEVQERAVVPLRTVLWRATMTNLLNPKIVLFYLAFLPQFVDADAGGAGVQLLVLGLLFVLVGLLVDSVIALAAGRLGEWLHRRHRVDTLLNRIAGTVFVALAARLVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1J6</accession>
    <name>F4F1J6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733879.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20625"/>
    <dbReference type="EnsemblBacteria" id="AEB45225">
        <property type="protein sequence ID" value="AEB45225"/>
        <property type="gene ID" value="VAB18032_20625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20625"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="MTRERMQ"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="28990" checksum="84405BD9CF146151" modified="2011-06-28" version="1">MSAIKVEGVSKVFAGAGGQSMLALSDVSLDIADGEFVVLLGPSGCGKTTLLRIIGQLESPTVGRVRLDHGDRPERADRPLGFVFQEATLMPWRTTGANVALPLEMAGMGRRERTEKVREMLTLVGLPEAENKLPHQLSGGMRQRVSIARALAHDPQVLLMDEPFGALDAQTRDMMNVELQRIWLENRKTVVFVTHSVSEAVFLADRIVMLGTKPGHIHSITEVTLPRPRTIDMTESAEFRHLTAELRRQIGEVQDTEARPAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1K2</accession>
    <name>F4F1K2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formyl-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733885.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20655"/>
    <dbReference type="EnsemblBacteria" id="AEB45231">
        <property type="protein sequence ID" value="AEB45231"/>
        <property type="gene ID" value="VAB18032_20655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20655"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_2_0_11"/>
    <dbReference type="OMA" id="HRPGFGT"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="399" mass="42913" checksum="1227A555E56B87D1" modified="2011-06-28" version="1">MHDGPLTGLRVIDASTILAGPLCCQILGDFGADVIKVEHPVAGDSMRGHGHAKDGIPLWWKEISRNKRTIGLKLSTPEGADLLRRLAATADVLVENFRPGTLERWGISPQQLQELNPGLVVVRISGFGQKGPYAHRPGFGTLAEAMSGFAHLTGEADGPPTLPAFGLADSICGIAASSATMVALWARTRNGGKGQVVDLSLLEPIMTAVGPGPTVYDQLGVIGHRHGNRSTNNAPRNTYRTKDGDWVAVSTSAQTIAERVLRLVGHPEVIDEPWFASGRERAAHADLLDDYVGGWIAERTRDEVMRAFEEAGAAVAPVYTARDIVTDEHVQAAEMVVKVPDADLGEVLMHNVMWRMSENPGRIRFTGRPLGADTDDLLVNELGCTPETVAELRAREIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1K4</accession>
    <name>F4F1K4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MmgE/PrpD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733887.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20665"/>
    <dbReference type="EnsemblBacteria" id="AEB45233">
        <property type="protein sequence ID" value="AEB45233"/>
        <property type="gene ID" value="VAB18032_20665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20665"/>
    <dbReference type="eggNOG" id="COG2079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026574_1_1_11"/>
    <dbReference type="OMA" id="AKFSMGT"/>
    <dbReference type="OrthoDB" id="688128at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="277"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="474" mass="49562" checksum="9FF69CBA1D294BF4" modified="2011-06-28" version="1">MAEQTLAQHLAAFAAGTGATALPDRLAASVRQRVLDILGLCVAAHRLPTSRAALDYVADQGGRGQAHVVGLPDAVPAAQAAFGNGVLAHSLDYDDTHLPSVLHPSAAVVPAALAAAQAAGADGTALTNAVAVGIETTVRLGMAGFDPVLNNSVFFEHGQHATSICGAMGGAVAAGMLLGLDENQLTDVLGVTASMAAGLIEANRTGGTVKRLHCGWAAHNAVTAADLVRRGFTGPPTVLEGRFGFYTAFLRGEADYEQITDGLGERWAVPDIFFKPYPANHFTHAAIDAGLALRAQGVPVDRITHIELRVPAAVIRTIGEPIATKRAPDTGYQAQFSGPYAIVAGLLGGGGLGLGLGDFTDELARDPQRRALMAHVDVVPDDECNKIFPYQFPAIVTVRTDDGRTWREEVLANRGGPQRPLSDAELAMKFRDNVAGRIAPETADQVVSTVLGLADVSDVNDLLRPLTHLRTDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1P6</accession>
    <name>F4F1P6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_26991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735122.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26991"/>
    <dbReference type="EnsemblBacteria" id="AEB46471">
        <property type="protein sequence ID" value="AEB46471"/>
        <property type="gene ID" value="VAB18032_26991"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26991"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_0_4_11"/>
    <dbReference type="OMA" id="NKGGGAC"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="35319" checksum="358EEF855EE57084" modified="2011-06-28" version="1">MPIDLRSDTVTRPTPGMREAMAAAEVGDDVYGEDPTVNALEAEVAALFGHEAALFCPTGSMANQIALQLSVPPGAELLCDADAHVITYEMGAAAAYGGITSRTWPAVGADVDPDVVAGMIRPDGYWAVPTAAIAVEQTHNRGGGGVIPLDTLRQLRRVADEAQVALHCDGARIWHAHVADGVPLASYGALFDTLSVCLSKGLGAPVGSLVVGAADKIERARMIRKRMGGGMRQAGVLAAAGRYALAHHIERLAEDHAKAARLAEAIAPFGVLAAPVRTNLVPLDLTKAPMDAHALAAAARAEGVLISVLGPRIARLVTHMDVTDTAVDQAATTLTHILRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F260</accession>
    <name>F4F260_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731421.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08155"/>
    <dbReference type="EnsemblBacteria" id="AEB42749">
        <property type="protein sequence ID" value="AEB42749"/>
        <property type="gene ID" value="VAB18032_08155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08155"/>
    <dbReference type="eggNOG" id="ENOG5033A46">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126534_0_0_11"/>
    <dbReference type="OMA" id="SCITAPI"/>
    <dbReference type="OrthoDB" id="2088585at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="172" mass="17520" checksum="BE721679A526A1E1" modified="2011-06-28" version="1">MTQPASGGWPDPSAGQPSSPPVDSTLPTSPPPVPSQPAGYDPYQPADPYGGMKFDLGTPAAPAPYPPAGYPPQPGYGYPQPGYGYPPPQPTNSLAIVALVLSLIGIGSCITAPIGAIMGHVAMRQIRERGEGGEGMAKAAIIVGWILTALLVLAIAVYVVLIIFAISSSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2E2</accession>
    <name>F4F2E2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732681.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14510"/>
    <dbReference type="EnsemblBacteria" id="AEB44014">
        <property type="protein sequence ID" value="AEB44014"/>
        <property type="gene ID" value="VAB18032_14510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14510"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_11"/>
    <dbReference type="OMA" id="WARSPRT"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="37946" checksum="39D00E606AC84667" modified="2011-06-28" version="1">MVQSTRTLGRSGIEVSALGMGCWAIGGPWAEGRTPLGWGAVDDAESVRAIRRALDLGVTLFDTADTYGAGHGERILGRALAGRRDVSIIATKWGYTFDEQTRQATGSDASPAYLHRAVRASLRRLGTDRIDLYQLHLADLPAARAQALIGTLEDLVTDGLIRTYGWSTDRTDRAAAFGDAPHAAAVQHSLSVLRDAPELLGVCEKYDLASVNRGPLGMGLLTGKYQPDSTLPHDDVRGMASGWLEWFRGGRPAPEWLRRVQAVRAALTADGRTLAQGALGWIWARSDRTIPIPGCRSVAQVEENAAALTLGPLTPDHFAEVERQLAALRTAALREADRPYWPSPMLPTARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2G8</accession>
    <name>F4F2G8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732707.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14640"/>
    <dbReference type="EnsemblBacteria" id="AEB44040">
        <property type="protein sequence ID" value="AEB44040"/>
        <property type="gene ID" value="VAB18032_14640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14640"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070045_0_0_11"/>
    <dbReference type="OMA" id="IMIVFEI"/>
    <dbReference type="OrthoDB" id="1560482at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="34381" checksum="12D8D63404462E42" modified="2011-06-28" version="1">MTTSLTDRYLAATLRSVPTARREEIADELRASIGDMVDGRTAEGVDAATAEREVLTELGNPAELAARYADRRLQLIGPTYYLAWQRLMIGLLSTIPAIIGVLMGVLEATVSDNAGGAIGKGIVAAFNVAVQIAFWVTLVFAVMERVGTPLNQPQWSVDQLPDEPVERDVSLTDVCASIVFLVLFIAALPWQHFQTVVGDGDRLPILDPALWSFWLPALLVVLVATIGLEVAKYRARRWTWPLVAVNAMLNLAYAVPVIWLLSNDKLFNPEFVARFAWLREGGIDTVARISIVVVVATTLWDVVDSALKARRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2K4</accession>
    <name>F4F2K4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733923.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20845"/>
    <dbReference type="EnsemblBacteria" id="AEB45269">
        <property type="protein sequence ID" value="AEB45269"/>
        <property type="gene ID" value="VAB18032_20845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20845"/>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="OMA" id="WLGGTHH"/>
    <dbReference type="OrthoDB" id="1337662at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="26367" checksum="B17A2C115DF73615" modified="2011-06-28" version="1">MVEPDQPSTARMIDFWLGGTHHYPVDVAAAHAFEQAYGPCAPVFRALRAFLGRAVRAIAATGVDSFLVFGAGVPTMGNVHEVAPEATVLYTDVDPVTIRLGQRLLAGSDRAGYGYGDATDIGTIDPALLHRFVPGWGRRPVGVVFLGLAAFLDDETLARTLDELYRASAVGSHLAIDFDTEELAGHPEALAMMGPAFRMRTPAAFAPLLGRWTPTSEGIVAVPHWRPDGAPEQVPDAFHGAVAVRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2M8</accession>
    <name>F4F2M8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mycothiol-dependent formaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733947.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20965"/>
    <dbReference type="EnsemblBacteria" id="AEB45293">
        <property type="protein sequence ID" value="AEB45293"/>
        <property type="gene ID" value="VAB18032_20965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20965"/>
    <dbReference type="eggNOG" id="COG1062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_11"/>
    <dbReference type="OMA" id="IHHYMGT"/>
    <dbReference type="OrthoDB" id="1859760at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017816">
        <property type="entry name" value="MycoS_dep_FDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03451">
        <property type="entry name" value="mycoS_dep_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="361" mass="37602" checksum="C5C5E7CDDBAAF9E4" modified="2011-06-28" version="1">MSQQVRGVISRSKGAPVEVTDIVVPDPGPGEAVVRVQSCGVCHTDLHYREGGINDDYPFLLGHEAAGIVEQVGAGVDAIAPGDFVVLNWRAVCGVCRACRRGRPWYCFATHNAAQKMTLTDGTELTPALGIGAFAEKTLVHAGQCTKVDPAARPAAVGLLGCGVMAGLGAAMNTGGVTRGDSVAVIGCGGVGDAAIAGAVLAGATTIVAVDTDSRKLDWARKFGATHTVNASEADPVAEIQAATGGFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPEMRVELPLLDVFGRGGALKSSWYGDCLPSRDFPMLTELYLQGRLDLDAFVTEEISLDGVEEAFARMHHGDVLRSVVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2X8</accession>
    <name>F4F2X8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27581"/>
    <dbReference type="EnsemblBacteria" id="AEB46589">
        <property type="protein sequence ID" value="AEB46589"/>
        <property type="gene ID" value="VAB18032_27581"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27581"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549734_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="292"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="387"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="496" mass="54653" checksum="0EC06D766F0380DF" modified="2011-06-28" version="1">MRLPPLPPDSDVESYSAIEAAPRIIPWLQALDAGSSDGMRIASLVSRLAPGAKPAHRIRIKSRILCEQVDPDDFPRLTAEHLEHLLLKYTYRPDDHQEVGYSKRTNVSAYLDLSGLPAGSPDERDLAGHLARYVAELISDGGLRPTVIAISKLASQGLLRTAAQRLSIPLIMVSPYGPNADAPIEGFFEPGDRAILLHDVALSGQHLVDCIVTLRSHGLTANDLVTLTRHRAADGSLPALMRENRINVHCASLLLPEKGRVLSGMPSVDNASPAVIPCVLCDVIQNKDGVPVRAMFDRDELPTEILRETQNFALIADVAPLMPGHALLVSKRHAISMSKCSPQELAELDLFRREAAEILAAAYSRDVVAFEHGLCNRSKMANCGIDHAHMHLVPLGFSLLPMLTQDFAPRQLRSLESLPEAAARRDEYLLLIEDADVVQLVFTETPTRQYFRRVVSAITGRDVWNWNDEVLLRENREARDWILGVHQVFNGSAGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F316</accession>
    <name>F4F316_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736427.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03555"/>
    <dbReference type="EnsemblBacteria" id="AEB47795">
        <property type="protein sequence ID" value="AEB47795"/>
        <property type="gene ID" value="VAB18032_03555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03555"/>
    <dbReference type="eggNOG" id="ENOG5031ZZ5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087941_0_0_11"/>
    <dbReference type="OMA" id="DEARPHF"/>
    <dbReference type="OrthoDB" id="1538944at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025968">
        <property type="entry name" value="YwqJ_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14431">
        <property type="entry name" value="YwqJ-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="127" mass="13984" checksum="C8FEF38589EAB93C" modified="2011-06-28" version="1">MTELRTLPLVAGALLVDGTIHTHTSVRGQTAPELHPIVRRFLHGLPVGQRERFTGWCAEPVLISDRLYAADADGPPVDTARARALLWGAKVRLTRVREEGDPRHGEVQPPCRSCAALLDWFGMEALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F329</accession>
    <name>F4F329_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_03630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03630"/>
    <dbReference type="EnsemblBacteria" id="AEB47808">
        <property type="protein sequence ID" value="AEB47808"/>
        <property type="gene ID" value="VAB18032_03630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03630"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821219_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="271"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="35171" checksum="CCE0EEA1241C6727" modified="2011-06-28" version="1">MLAGMANPDQKPTDPADADPRGGAARWGAPLVLAAAVGMLLVATPWWGVDGLDETSSPWFVDLERLVLGLANFAAVAAVALSRYRLGAACVVATVPWVLSPLLGAVAWAWWSAVLAVLGIAVLDGARRLSLAMAALAVTLAVVYCTSGMYWQVPIVGPVNLFSREPDRWLDETRLIYLAFYLGAVGVVVLLAAVLRRRRAARLRSIAVTPAAAAAPMPPAVESPEVTGPGVVEAESSVGPVGSEVAEVGPQATPVGPAAVGAGAQVLTGPWAERIATLTAREREVLLAVARGRSNAEVAADLGIGDETVKTHVSEVLRKLGCRDRVQAVIAVYESGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3L6</accession>
    <name>F4F3L6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ordered locus">VAB18032_15060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732789.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15060"/>
    <dbReference type="EnsemblBacteria" id="AEB44124">
        <property type="protein sequence ID" value="AEB44124"/>
        <property type="gene ID" value="VAB18032_15060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15060"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_1_2_11"/>
    <dbReference type="OMA" id="NMHGEPV"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="20140" checksum="EDB667D0A5CA1590" modified="2011-06-28" version="1">MTVQPIRLFGDPVLRTPADPVVDFDVELRKLIADLTDTMRDSAGAGLAAPQLGVGLRVFTFDVDDVVGHLVNPVLEFPDAEEQDGPEGCLSIPGMYFDTKRRQNVIAKGFNGYGDPLQIVGTGLMARCVQHETDHLDGVLFIDRLDPAGRKEAMKAIRQAEWYDDGAPPTVKVSPHAAGSPFGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3M4</accession>
    <name>F4F3M4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_15100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732797.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15100"/>
    <dbReference type="EnsemblBacteria" id="AEB44132">
        <property type="protein sequence ID" value="AEB44132"/>
        <property type="gene ID" value="VAB18032_15100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15100"/>
    <dbReference type="eggNOG" id="COG0307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_2_1_11"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="OrthoDB" id="1276859at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="21684" checksum="27DCBFE436055213" modified="2011-06-28" version="1">MFTGIVEELGEVVGVTPTAQDSVLVAVRGPLVTSDARHGDSIAVNGVCLTVVDVDGGVFTADVMGETLRRSALGTLRAGDPVNLERAAALGSRLGGHLVQGHVDGVGEVLAREPAPRWETVRFRLPVALSRYVVEKGSITIDGVSLTVAEVGDDWFSVGLIPTTLALTTLGTRAVGDPVNLEMDVLAKYVERLLGARPADAPVPGPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3N8</accession>
    <name>F4F3N8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA/rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732811.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15170"/>
    <dbReference type="EnsemblBacteria" id="AEB44146">
        <property type="protein sequence ID" value="AEB44146"/>
        <property type="gene ID" value="VAB18032_15170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15170"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_1_11"/>
    <dbReference type="OMA" id="FLAEGPQ"/>
    <dbReference type="OrthoDB" id="1697536at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="265" mass="27253" checksum="345ADCFCF0A02EB9" modified="2011-06-28" version="1">MPFTPRTPRVVAARRLQRRRDREATGRFLAEGPQAVREALARSRTVLELFGTPTALDRHADLAAAAAGADVPVSEVTDEALAALAETVAPQGLVAVCQHLDVPLATALSRGPRLVGVLAGIRDPGNAGTVLRTADAAGAAAVVFAGEAVDPYNGKCVRSSAGSLFHVDVVRERDPAAVVDAARAAGLVVLAATGYGEADLDDLADAGRLAVPTAWLFGSEAHGLPDELIAAADARVRVPLHGRAESLNLAAAAAVCLYASARAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3S6</accession>
    <name>F4F3S6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21385"/>
    <dbReference type="EnsemblBacteria" id="AEB45377">
        <property type="protein sequence ID" value="AEB45377"/>
        <property type="gene ID" value="VAB18032_21385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21385"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_11"/>
    <dbReference type="OMA" id="VHRFMAD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1284" mass="139435" checksum="233F5EE4D843B0A9" modified="2011-06-28" version="1">MTTTEQQGGPTAAVGAGEPVAHCTIVSFVSPTSGNSGRSSAVANIAWILASNGKRVLAVDWCTKTPRVYDYLRSFRIDALGSAGVLGAELAALTSPHPDAPAHRTSALSGPTAPEQGVLYRYAIPGTSFGFALVGVSLEVDGLPKVDPVRARLLLRQAGYDYVLIDTPVDLTMPGVSYAAMLSDVAVVSIPPRRPALQQAADLADQLQRQATGGIRILAAPTLRDVSQPWYGEARDSARKAFAKLLDESANAPNSSVEIVEVPEPTYDTYDDVLAVLADSPGEQSSLLSAYEQMASWISGGAVTRVAEVPDRIRRRYRRGVLLERAESADEIHVLYEPPERPYADWIAGQLQRADVHVHPHALRGGAAPTFEADATVLALLSPGVVKALGAGLTAAPGTDIEVFGVLTEGQPPNQLDPSRIIDLREVDAARAQPLLLSQLGLIAPTQPPGDLRSAPRYPAETERRLRSNLPTRNGSFVGRSDYLERLRDQLTDGGGPVTLSGGAGVGKSEIAREFAHRFAYDYDVVWWIPAQDRETVQTALGELAQEINVVDSVGAAEAAVAALSEPRSTIARWLLIYDNADDAEVLAGLLPRPGTGHILFTSRDDGSSNLPSPLEVAAFSGDESVTMLRRMLGISSADARSIAAAVDHLPLALRLATAWIRERTRILEREGVPNLVAVSRSVEELLSSLRQPGVEEPTERIPGSRTSTVARVLDNTLATLRDTEFGALAIRVAEIAAFLSPEGIGLPLLRSTPMLVQLAAAAETDPEELLLAAGEIDLVLAVGARFALFDIDWGRGAALRMHRAIQFLIRESIPEPQRRERHRQVLHGLAGYAPSDPEADDRRYLPIFEELQRHLVPSGALTADDARVRHWVVKQVRYLFYFGDSDAWQSAVRLAQQACDRWAAGGDFDQLTMRLFVQTANLHRVLGRPQEALRLDEQVLSEQRRRCGLRHFRTLIAGRGRGGDLRGLGRFEDALVEDQATLAGYHEVLGGDHPNTRMAINNLAISFQLTGDAREALRLAHQLFDRWMSLFGPDEPATWRAACLVGTLEREVGEYELSLTTLRGTLERVHELRSASQLDELQVNRSLAVTERRLGLTLAAKKRSIETFRGYRDRFGEDHPLTRSSLLSMAVDYYRAGDAGAAVEHAMRCLRGYERTLETGHPFTAVCSVNLGICHRGTGEYDHAIRDGERGMRTLRARLGDAHPWTLTAATAQAGHLAARGDLADAVRLQQETHLTSLRFLGRRHPCTGDAAANLAAIVARRDGTDDGGVAALTDTDIDVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F487</accession>
    <name>F4F487_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736532.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04090"/>
    <dbReference type="EnsemblBacteria" id="AEB47900">
        <property type="protein sequence ID" value="AEB47900"/>
        <property type="gene ID" value="VAB18032_04090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04090"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057502_2_1_11"/>
    <dbReference type="OMA" id="EAWFAHE"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="24971" checksum="CDFF6AFF5A83F7FB" modified="2011-06-28" version="1">MRSELFSAANLEQESAQPGMRLQNSKMLKIELNGEMLARVGSMVAYQGHVQFQALGSGGLGNFLKQKLTGEGVPLMKLTGQGDVFLADFAKDVHIIDLEPGDALSINGSSVLAFDPSLQYDIKMVGGAGMASTGLFNCVFTGHGRIAVTTRGTPVVLAVDAPTYVDPQAAVCWSAGLQTGYHRADQLGLGTLLGRTTGEAYTMSFAGQGFVVVQPSEEPPIMGSGQQDQGGVLGGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4C6</accession>
    <name>F4F4C6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04285"/>
    <dbReference type="EnsemblBacteria" id="AEB47939">
        <property type="protein sequence ID" value="AEB47939"/>
        <property type="gene ID" value="VAB18032_04285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04285"/>
    <dbReference type="eggNOG" id="COG3809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147819_1_0_11"/>
    <dbReference type="OMA" id="GVQIEQC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12420" checksum="74D01C7815244CEC" modified="2011-06-28" version="1">MRQYERSGVVIDQCGECRGIFLDRGELEKLFEAEANWNAKQTPPAPQPPQHVAQPGGYPPPAPAPHQPGYGAVPPPGYPAPAPAYGHGQQHYGYHGHYRRKKRKSFLDDMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4L7</accession>
    <name>F4F4L7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">argD</name>
        <name evidence="5" type="ordered locus">VAB18032_15235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15235"/>
    <dbReference type="EnsemblBacteria" id="AEB44159">
        <property type="protein sequence ID" value="AEB44159"/>
        <property type="gene ID" value="VAB18032_15235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15235"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_11"/>
    <dbReference type="OMA" id="PFMVPTY"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="421" mass="42608" checksum="0727A2332B27ECBE" modified="2011-06-28" version="1">MTALSDRWRQSMMDNYGTPPLALVSGSGAVVVDETGREYVDLLGGIAVNSLGHAHPAVVAAVSKQVATLGHVSNLFISEPPVALAELLLALAGRPGRVFFANSGAEANEAAFKLSRRTGRTHVVATVGGFHGRTMGALALTGQPAKADPFRPLPGEVTHVPYGDVAALEAAVTDATAMVILEPIQGENGVVVPLAGYLAAARRITARHGALLVLDEVQTGIGRTGHWFAHQAEGVEPDVVTLAKGLGGGLPIGATLAFGPAADLLAPGSHGTTFGGNPVSCAAALAVISTIAHEGLLDHVKRVGERIRRGIDALGHPLVAGVRGAGLLLGVTLTAPVAPAAAEALRTAGFLVNPVQPDVLRLAPPLILTAAQADAFLAALPIALTAAASVAPGATDQHPRGPIAVHTTPTDVDPTPTEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Y8</accession>
    <name>F4F4Y8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">kdpB</name>
        <name evidence="15" type="ordered locus">VAB18032_21885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734130.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21885"/>
    <dbReference type="EnsemblBacteria" id="AEB45477">
        <property type="protein sequence ID" value="AEB45477"/>
        <property type="gene ID" value="VAB18032_21885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21885"/>
    <dbReference type="eggNOG" id="COG2216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_11"/>
    <dbReference type="OMA" id="ILWLWFT"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="406"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB45477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="723" mass="75666" checksum="D97396C45217A902" modified="2011-06-28" version="1">MTVATPHACTPGSPATHGNRGGGLLDPRQLLRSLPDALGKLDPRSLWRNPVMLIVEIGAAFTTVLAVAQPSVFAWAITAWLWLTVVFANLAEAVAEGRGRAQAAALRTARADTVATRLLDWTAGTAPGSYRTESVPAPHLRQGDIVVVEAGETIPGDGDVVDGIASVDESAITGESAPVIRESGGDRSAVTGGTKVLSDRIIVRITQKPGESFIDRMIALVEGANRQKTPNEIALNILLAALTIIFLLAVVTLQPLAIFSKEFQAAAADSPAITDDGVTGIVLVALLVCLIPTTIGALLSAIGIAGMDRLVQRNVLAMSGRAVEAAGDVNTLLLDKTGTITLGNRQAAEFLPVEGVTAGQVADAAQLSSLADETPEGRSVVVLAKNAFGLRQREPGLMPHATFVPFTAQTRMSGVDLTPGDGGPARRIRKGAAAAVMQWVRQHGGHPTEQVGQVVDEISGMGGTPLVVAEHVDDQPARALGIIHLKDVVKAGMRERFDEMRRMGIRTVMITGDNPRTAQAIADEAGVDDFLAEATPEDKLALIRTEQAGGRLVAMTGDGTNDAPALAQADVGVAMNTGTSAAKEAGNMIDLDSDPTKLIEIVEIGKQLLITRGALTTISIANDIAKYFAIIPAMFAGLYPSLDVLNIMRLSGPESAILSAVIFNAIVIVALIPLALRGVRYRPAAASSLLRRNLLIYGLGGIIVPFLGIKLIDLLVQFVPGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F513</accession>
    <name>F4F513_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734155.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22010"/>
    <dbReference type="EnsemblBacteria" id="AEB45502">
        <property type="protein sequence ID" value="AEB45502"/>
        <property type="gene ID" value="VAB18032_22010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22010"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_739501_0_0_11"/>
    <dbReference type="OMA" id="AWEKNWG"/>
    <dbReference type="OrthoDB" id="884913at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="190"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="359" mass="40730" checksum="1D84EA1FD9990A49" modified="2011-06-28" version="1">MRTRFERVTGRRDLRDFCTLTDRLYAGEPCHVPTPRQQIRRWWRDGVPMYLLRDATGTVIGRTTLHTDAAFDAKLGRRCQLFGLTEFTEPAAGPLFDAITAHAAADRELLFGPVALLPNQAGGVITSGYADRGFVDSAWNPPHYPIAYEAYGFHRRFEADTWICPVPTPPQPKPSTYIKSDGVRLEVHRGDLRRLDEQLDLLRGMLNDSFAQLGYYTPISAEQLRRQTDGLAYLLDESLLLYLTRDGAAVAFVLCVPDISEFLAGVRGNLHPVNQLRLLASRRRYRREAVLIIKGVVPRYQGHGYQRLLSAHLHHNLYAAGYTTLRSTYVERDNPASAAQYRRLGGRPLHGYTFYAKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F549</accession>
    <name>F4F549_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_28301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735381.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28301"/>
    <dbReference type="EnsemblBacteria" id="AEB46731">
        <property type="protein sequence ID" value="AEB46731"/>
        <property type="gene ID" value="VAB18032_28301"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28301"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_2_11"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="270" mass="30265" checksum="51C13A8931798593" modified="2011-06-28" version="1">MIRSTRAGRREPVPPTPHPSGARPPALPPGAVPKHVAVVMDGNGRWAKERGLPRTKGHEAGEFSLFDTVEGAIEMGIPYLSAYAFSTENWRRSPDEVRFLMGFNRDVIRRRRDQLIDLGVRVVWSGRAGRLWKSVISELQTAEEMSRGNSTLTLQFCVNYGGQAEIADAAAAIARDAAAGKLDPAKVTEKTVARYLYHPEVPEVDLFLRPSGEQRTSNFMLWQSAYAELVFLDTLWPDFDRRHLWYACELYAQRDRRFGGALPNPVAPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5R2</accession>
    <name>F4F5R2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732939.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15825"/>
    <dbReference type="EnsemblBacteria" id="AEB44275">
        <property type="protein sequence ID" value="AEB44275"/>
        <property type="gene ID" value="VAB18032_15825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15825"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1524494_0_0_11"/>
    <dbReference type="OrthoDB" id="1759737at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="18656" checksum="0325E9F0D56CBE5C" modified="2011-06-28" version="1">MSRQELADAVNAYAYRRTGRRVAVDARYVGKLERGEHRWPYEHCRTALREVLGKSTDAELGFFIIHGHATDPEVDPALEMPSGMPAPGSEDSAVGVRRTVGDAGGGLVVPGGAATVRVSLTVAAEQVRVIRDQGPTGRVAVLAGPVEVLIEPSDTATVVTPDADPLGHDGRQAQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F611</accession>
    <name>F4F611_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734223.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22350"/>
    <dbReference type="EnsemblBacteria" id="AEB45570">
        <property type="protein sequence ID" value="AEB45570"/>
        <property type="gene ID" value="VAB18032_22350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22350"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_11"/>
    <dbReference type="OMA" id="FDVMPMP"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307684" evidence="1">
        <location>
            <begin position="28"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="426" mass="46444" checksum="5951228D60AD9158" modified="2011-06-28" version="1">MTSLWRRACATLLTVLLVGTGCSSGDKATDDDGITVVLFGDAEEIAGYRDLVAGFTTAHPDIPVTLSPVATQDELMARLTTSFAGGQPPDVFLLNYRRYGQFAAQGVIEPVQSYLDSSEEIRESDFSPRALDAFRFDGRELTCLPQNLSSLVVYYNVDLFTAAGIPAPTAGWTWDDFLAAAKALTRDGRYGVGVDPSLPRLAPFVWSNGGELVDDPDKPNRLTLTDNPSSRAAVDWFLDLQSRHGVVPPDAEEQSESSEARFLRGTLGMYLNSRVAVPTLRTITDFTWDVAPLPVAPGGRPASILHSDAYCMSAGLADHGPAWRFIEYAMGDAGQRTLAESGRTVPSRLEVANSPAFLDPTKAPRSSQVFLDAEPYLRATPRTGSWSRVEKEGNSLLAEVFYGRIDREDGLRQLEDRVRPLFSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F694</accession>
    <name>F4F694_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_28876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28876"/>
    <dbReference type="EnsemblBacteria" id="AEB46846">
        <property type="protein sequence ID" value="AEB46846"/>
        <property type="gene ID" value="VAB18032_28876"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28876"/>
    <dbReference type="eggNOG" id="COG3346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047737_0_0_11"/>
    <dbReference type="OMA" id="GYVVQWW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="29131" checksum="0B35F5DEBBED1633" modified="2011-06-28" version="1">MYRFLLTPRWLGILALTLVAATVMVLLGNWQLDRYRGRTAINEQIDAGLQMAAVPLREALAAPTGGPGTIGPPPAEERTYTRVTLTGRYDTDNIVLVRGRTVDSKVGFEVLTPLVLTDGTAVLVDRGWIPPAPGGALAQPEMPATPAGDVTVEGRIRASESGDAKVSRRDGQLESRRISLPQLAPQLPYPLHGGYVLLDEQTPAADPVFKAVPVGHANNWQNLGYVVQWWIFGAMTVVGFGWIARREARRLAGVTDDRPRDRAADPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6N9</accession>
    <name>F4F6N9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16305"/>
    <dbReference type="EnsemblBacteria" id="AEB44367">
        <property type="protein sequence ID" value="AEB44367"/>
        <property type="gene ID" value="VAB18032_16305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16305"/>
    <dbReference type="HOGENOM" id="CLU_2866570_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="6642" checksum="CFF9374629D99BCF" modified="2011-06-28" version="1">MAAKRSGELRQQPPLTFGAANAALAAGPITHAQRQIAETADTGVFVIVGPTNHQDNETAVTNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6S3</accession>
    <name>F4F6S3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_22490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22490"/>
    <dbReference type="EnsemblBacteria" id="AEB45598">
        <property type="protein sequence ID" value="AEB45598"/>
        <property type="gene ID" value="VAB18032_22490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22490"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_0_0_11"/>
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    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017778">
        <property type="entry name" value="ABC_transptr_urea_perm_UrtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
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        <property type="entry name" value="PTHR30482"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482:SF4">
        <property type="entry name" value="PTHR30482:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03408">
        <property type="entry name" value="urea_trans_UrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="386" mass="40843" checksum="F2283B67A07E780C" modified="2011-06-28" version="1">MTTVARDSRTVVDPAPPPAKPAAGPSRHRFRAVAGFAFGAALLFAVAPLVLSDFRLSLLAKYLCVAMVAVGIGLAWGRGGMLALGQGVFFGLGGYAMAMHLKLADAGPGNMPDFMLLYGQLDELPLWWRPFASPWFALPATVLLPMAVAFVLGSLVFRRRVRGAYFAILSQALAAAMVILLIGQQGTTGGTNGLTDIQGFFGYDLDDPVNQRMVYFIIAGTLLALLVLARHLMQCRYGELLVAVRDGEERVRFLGYDPAAVKLVAYVVAAGMAGLAGALFVPAVGIISPALIGIVPSIEFVIGVAVGGRATLLGPVLGAVAVAWARTALSERFPGGWTYLQGLLFVVVVAFLPGGLASLIGLARRGDGERWFGRLRRTRRTEGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F793</accession>
    <name>F4F793_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminopeptidase Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_10165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10165"/>
    <dbReference type="EnsemblBacteria" id="AEB43151">
        <property type="protein sequence ID" value="AEB43151"/>
        <property type="gene ID" value="VAB18032_10165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10165"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_0_2_11"/>
    <dbReference type="OMA" id="YRVNNCV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312743" evidence="5">
        <location>
            <begin position="23"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="6">
        <location>
            <begin position="133"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="7">
        <location>
            <begin position="254"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="534" mass="55390" checksum="2E567B355C7FE68D" modified="2011-06-28" version="1">MVAAIAASTLLGTMALAGPAQASPNNNTVDKLTKAVTVKGVLKHLDKFQDIANANNGTRASGTPGYDASADYVVGLLKKAGYQVSRQQFDFAFYEEFGSSFAQVAPTATTYVDGVDYTLMDYSGAGVAQGLVVPVDLALDPPRASTSGCEASDFAGVDVAGKIALLQRGTCAFGDKVVNAEAAGAIGAIVMNQGNGTPEANADRYDLFAGTLGAPVGIPTVSVSYNTGAQFATTPGLTLRIEADTTSEIRSTENVIAQSKHGRTDNVVMAGAHLDSDPAGPGFNDNATGSAALLEVALQMAKVKPYNAVRFAWWGAEEAGLIGSQYYVDSLSEQQVADIALYLNFDMIGSPNYVFGVYDGDDSAQEGSGPGPEGSAQIEKVFEKFFASRKLPTVASDFTGRSDYGAFIDVNIPAGGLFTGAEGVKTAEEAALFGGVAGVAYDPCYHLACDSRTPVADGADAAVYKSLGKKYKLHGNVNVFALDVNSDAVAASVITFAFDTSAVNGVPGKAPGKGKGKGKGHKHHHKHGHKHHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7G4</accession>
    <name>F4F7G4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">abyX</name>
        <name evidence="4" type="ordered locus">VAB18032_16485</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733063.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16485"/>
    <dbReference type="EnsemblBacteria" id="AEB44403">
        <property type="protein sequence ID" value="AEB44403"/>
        <property type="gene ID" value="VAB18032_16485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16485"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_1_11"/>
    <dbReference type="OMA" id="NELPVTW"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEK75493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="396" mass="43370" checksum="4262F72766BA848E" modified="2011-06-28" version="1">MTDVQLPAFPMTRTCPHQPPEGYAALRENGPLAQVRLVGDRTAWVVTDHDVARTLLVDPRLSSDRLRPDFPVLVPRMSAAKLVPLVGMDPPVHTQRRRMLIAAFTVHRTQQMRPEIEEIVSARLDAVLQEGPPVDLVPTLALPVPSTVICRLLGVPYADHDFFESQTQRMVLGSSTAQEAAGAAAALTEYVDTLIGEKQTKPGEGLLDELIASHLDTGQITRRDLAETVMFLLVAGHETTANMITMSIVGLLENPEQLDRLRSDWSLLPNAVEELLRYLSVADEIQRVVAEPIEVAGHVLRVGDAVYLPAAASNRDPAAFPDPDALDVSRRARHHLAFGYGIHQCLGQNLARAELEVTLRALFERLPTLALAEPLSSLPVKPGGSVQGVYRLPVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7I7</accession>
    <name>F4F7I7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_16610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733086.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16610"/>
    <dbReference type="EnsemblBacteria" id="AEB44426">
        <property type="protein sequence ID" value="AEB44426"/>
        <property type="gene ID" value="VAB18032_16610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16610"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="TERVLFM"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="240" mass="25408" checksum="83B4DE74E0808AB3" modified="2011-06-28" version="1">MSSEPLLRVRGVHRRFRTGPTVVHALRGVSFDVSAGCMVALVGRSGSGKTTLLNVIGGLDRPDAGTVHVDGADVTALDEDGLSRLRREKVSYVFQSFGLIPVLSAAENVAAPLRLARVAPAERERRVELLLELVGLADHARQRPAELSGGQQQRVAIARALAASPRLLIADEPTGQLDAETGLSVMALLRGVVESEGVTALVSTHDPVMMALADRVIRIHDGHLHDEAAGQPDEPVPDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7M4</accession>
    <name>F4F7M4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733120.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16795"/>
    <dbReference type="EnsemblBacteria" id="AEB44463">
        <property type="protein sequence ID" value="AEB44463"/>
        <property type="gene ID" value="VAB18032_16795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16795"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060397_1_1_11"/>
    <dbReference type="OMA" id="PVAELGC"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="219" mass="23759" checksum="CBAF00FF58E990E8" modified="2011-06-28" version="1">MDASTEELRDAHNVLSEWYAENLVGVLESMPVERAMLDLFAELTLTVGAEVADVGCGTGRLLPYLADRGLSPRGVDLSPGMVDVARREHPGFGYAVADLRELPFGDASLAGVVCWYSLIFLAPDARVRAFAELARVVRPGGYLVAAFKHGDGTGHRNSPGSRVGSLGIDFDRYWLSAREMEDRFTAAGFALVFQGETPPEDAEPRYGYMLVRKTGSTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7V9</accession>
    <name>F4F7V9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_29316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29316"/>
    <dbReference type="EnsemblBacteria" id="AEB46934">
        <property type="protein sequence ID" value="AEB46934"/>
        <property type="gene ID" value="VAB18032_29316"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29316"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_3_3_11"/>
    <dbReference type="OMA" id="AYGPDIR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="269"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="462" mass="49860" checksum="4B4F56F5FE660B4E" modified="2011-06-28" version="1">MRTLVVLDATVLTLAVLAGYAARFGEAAPRGTHVPYVLVAPGLVLAWLLSLKAMRCYDDRVIGYGADEYRRVSMASLRLAGAVAIAGYIADVGVSRGFLAISFAVGLVGLELARFAARKRLHRARSAGTGWSRRVLVVGDTAHVLELVHTLRREPYAGYQVVGACIPDALLAPVAQRLGDVPVVGSFRGIPEAAAAIGADTVAVTASGELTAARLRRLGWQLEGTGIDLVLAPALTDVAGPRIHTRPVAGLPLIHVEAPEFRGIRKLVKGLVDRSISLVALALLLPLLVVIALAIKLNSRGPVLFRQIRVGQGGREFGVFKFRTMVVNADALLAELAARNETDGLMFKMRDDPRVTRVGRLLRKWSLDELPQLVNVLLGQMSLVGPRPPLPSEVARYDGDVARRLLVKPGMTGLWQVSGRSDLSWEDGIRLDLYYVENWSLAADLTILWKTFGAVVNSRGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7X5</accession>
    <name>F4F7X5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginase/agmatinase/formiminoglutamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29396"/>
    <dbReference type="EnsemblBacteria" id="AEB46950">
        <property type="protein sequence ID" value="AEB46950"/>
        <property type="gene ID" value="VAB18032_29396"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29396"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516724_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="527" mass="54352" checksum="D414980347178F4E" modified="2011-06-28" version="1">MMRRIAVLDAPSNLGLRPPTLTSVPGCGKAPGALRDQGLLPRLRARDAGCLTSPRYDAGDWRPGDGVCHAREIADYSAALADRVGAIIDRGEFPLVLGGDCSILLGSALAMHRLGEEVGGRIGLIYVDGHSDFRHPGNASYVGAAAGESLALVTGRGQADLAAIEGRRPYFRDIDVVVLGIRAQDEYRLDLQAAGIVTRPVPALRAEGAARTAQWAHEQLADCAGYWVHVDVDVLDPAVMPAVDAPDAGGIAFAELEILLAGLVDTPHCLGVELTVFDPDYDRDGAYAAEIVNTVVAGLRPVTAPAPPLTRPGIGRTDRTAPAPRRTTERTPGRADRADLSAVPDQAARGDLSIRPDQAARGDLVEHADPNDRADPDDRGDLVALGDLDGRAHLADGADLADGGDLGDRAEQAVRAAGTVAVPDPRDTDFSAGPGSLRRPAAEEGSAGPGSLRRSAVDDQAGPGADGLRPVAAEPTDDPRGAGGLRLVPADSIGDLRAAGGLRPVVAEPPAALASPTDSDAPADGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F875</accession>
    <name>F4F875_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731907.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10590"/>
    <dbReference type="EnsemblBacteria" id="AEB43236">
        <property type="protein sequence ID" value="AEB43236"/>
        <property type="gene ID" value="VAB18032_10590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10590"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_0_11"/>
    <dbReference type="OMA" id="CITHHYS"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="31189" checksum="4EDAEC24667EE2B7" modified="2011-06-28" version="1">MKINGAELVVEAFGPEDGPAMIVHHGAPGLGSRSEPKRSFGPFSDRLRVIVFDARGSGESSDDEPFTHEQWVADVDAIREHFGYEKIVMAGGSYGGFIAMEYAIAHPDRVSALVLRDTAADTAHDHLAVERARNTDRSVIPEWVIDRIGTGRFESNEQLREYWRAILPLYDHQHDPAKDEARLAATRFHYRTHNAAFGQNMPRYDLKPKLPSITCPTLVTVGRHDWRTPVEASQVIADLVPHGELVVFENSGHSPQLEEPELFQQVVRDFLHRAGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8C8</accession>
    <name>F4F8C8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733130.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16845"/>
    <dbReference type="EnsemblBacteria" id="AEB44473">
        <property type="protein sequence ID" value="AEB44473"/>
        <property type="gene ID" value="VAB18032_16845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16845"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057862_1_0_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="32749" checksum="41221DDEBA642A87" modified="2011-06-28" version="1">MTELGDYLRSCRAKVSAEAAGLPSTGHRRVPGLRREELAMLAGVSVDYIVRLEQGRAKTASPEILQALAQALDLRPDEQEYLFRCAADAKGPAARANPAPPDAQRVSTATRVLLDSMTAVPALVLGRRMDIIGWNTLGAALFTDFSVLAPQHRNHIRLAFLDQRVRSLYRDWETVAKECVAYLRMDAGRYPQDPALARLVGELSMKDEDFRHWWSTHRVRAQRSGRKHFLHPTAGELSLDFQVLDVRGTTDQTLLVYTAEPNSRSAQALAFLSGWTRTTREEPAARLTSHHPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8D1</accession>
    <name>F4F8D1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44476">
        <property type="protein sequence ID" value="AEB44476"/>
        <property type="gene ID" value="VAB18032_16860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16860"/>
    <dbReference type="eggNOG" id="ENOG5032UGJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2235425_0_0_11"/>
    <dbReference type="OMA" id="IDAYRHW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="92" mass="10209" checksum="7AE83BE63B0A3353" modified="2011-06-28" version="1">MIEEATVDAYGDDEQLTGLFTMIEEHLAVPFTTTVLGVEVTVRKIDLTADTIVALCARGHHRQRIGLLDLPLPTPPPDGAGWIDAYRHWAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8G9</accession>
    <name>F4F8G9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase type 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733169.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17050"/>
    <dbReference type="EnsemblBacteria" id="AEB44514">
        <property type="protein sequence ID" value="AEB44514"/>
        <property type="gene ID" value="VAB18032_17050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17050"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_2_0_11"/>
    <dbReference type="OMA" id="DTWHTAG"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="232"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="384" mass="41220" checksum="6D19C1A38B1AC5D4" modified="2011-06-28" version="1">MSEVLDAVRNIVPRLRENGLESEERRWILDENTELLDKAGVFRLAVPKRFGGLDAPLPEQVAVLTEIARGCGSTAWAAVAWVSTAWMATLYPDQTQEEIFAGGSVRISGGFTPTAKAVPTDGGYLLNGSWRFNSGCRGAHWDLLAAILEEPDGTETEVFAMVPMSDLSIADDWHVSAAAATGSSTTTARDLFVPAHRVVTGEVALTTGAPGRTPTAPGRSYSLISYVVAESAAAYIGMAKAALELFLERLPGRGLAYTSWTDQRQHPLIQHRVALAANKITAAETLSASYVDMLQRRADAGEEPTWAEKAAVRGQAGTAIQLVKEAVQDLHTIAGASALSKFAPFQRFHRDLLGLTTHGLMSPDMSLEVHGRVLVGLDPDTPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8H1</accession>
    <name>F4F8H1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733171.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17060"/>
    <dbReference type="EnsemblBacteria" id="AEB44516">
        <property type="protein sequence ID" value="AEB44516"/>
        <property type="gene ID" value="VAB18032_17060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17060"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_11"/>
    <dbReference type="OMA" id="AGANRMG"/>
    <dbReference type="OrthoDB" id="543793at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="5">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="523" mass="55999" checksum="36A8ADA533D88AD7" modified="2011-06-28" version="1">MEFDYVVVGAGSAGCAVAARLSEDPTVTVALLEAGGPDDHPDIRVPLGALELIGSELDWDFGTLPQPHLGGREVRWPRGRVLGGSSATNFQMWVPGHAEDFTSWPPSWSWEQVRPWFRRAEHWAGPAEDRGALGTGGPLWISPQRDPDVSSLRFLQACAEVGLAPVDGALAGPDNRGYALTPVTQRDGARWSSADGYLRPALHRPNLTVLTGAQAHRVLIDDGHRATGVRLADRTVTARREVVLSAGTVGSPHLLLLSGIGDPDDLHAAGVRPQVELPAVGRGLHDHMILDLAVRADDATRFLQDGRERYQRDRMGPLTSNIGEAVALLRADGAAGAPDVELIWSPMAFDDTGTPIPGYTLGVVLLRPRSRGRLTLGSADPHTPPRIDPGYLTDDADLQTFVAGVRFAERILDSAALRTLHQGPVVPWPADGTVAEYVRQRAQTVFHPVGSCRFGDVVDADLRVHGVTGLRVADASVIPEAPRGHTHAHAVMIGERAADLIRASGVSHPAAQEVVDERPVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8J9</accession>
    <name>F4F8J9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733199.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17200"/>
    <dbReference type="EnsemblBacteria" id="AEB44544">
        <property type="protein sequence ID" value="AEB44544"/>
        <property type="gene ID" value="VAB18032_17200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17200"/>
    <dbReference type="eggNOG" id="ENOG5031JYX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1481380_0_0_11"/>
    <dbReference type="OMA" id="EFGCLEP"/>
    <dbReference type="OrthoDB" id="2054739at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312797" evidence="2">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="18647" checksum="A5180035B759BF24" modified="2011-06-28" version="1">MRAGKVTWLAAVVALAVLASGCAAPGTRDGDVPATPTDTSSPALSSSPPVLAEPTGRQPDAPANHADNNGWKRRHELSAADERAGRELAARIRPPLEALRAAGDFAPASTQGALLDLGIQADAITVAAMRPPIGQETPPPGAVYAVRFGNVGCVIGDVRPDRVMVEVTGAAAEFGCLEPFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8M0</accession>
    <name>F4F8M0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_23325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734415.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23325"/>
    <dbReference type="EnsemblBacteria" id="AEB45763">
        <property type="protein sequence ID" value="AEB45763"/>
        <property type="gene ID" value="VAB18032_23325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23325"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020726_2_0_11"/>
    <dbReference type="OMA" id="FTPMLFM"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF3459"/>
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        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="98"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="241"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="305"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="374"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB45763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="573" mass="64015" checksum="8CC7E0BD90FA3EA6" modified="2011-06-28" version="1">MSEFTVWAPEAKRVRLRLPDADHEMRAGRGGWWRVEVPDAGADYAYLLDDDNQALPDPRSLWQPFGVHGVSRAYDHSAFAWTDSAWTGRQLPGSILYELHVGTFTPEGTFDAAIDKLDHLVDLGVDMIELLPVNAFNGEHNWGYDGVCWFAPHEPYGGPDGLKRLVDAAHAKGLGVILDVVYNHFGPSGAYAPRFAPYLSDRTTPWGQAVNLDGPHSDGVRRFILDSVLMWLRDYHVDGLRLDAVHAMPDTRAVHLLEEIAVEVESLSVHLGRPLSLIAESDLNDPRLISPREAGGYGLQAQWNDDAHHALHTLLTGERQGYYGDFGTMECLAEVLTGAFFHTGTWSSFRNRQHGRPVDPRTPGHRFVAYLQNHDQIGNRAVGDRLSASLSPAMLRVGAVLLMASPFTPMMFMGEEWAASTPWQYFTSHPEPELATAVVLGRRQEFATHGWTAEAVPDPQDRQTFVRSRLDWAELDKPEHRAMYDFYRRLIALRKSRPELSDPHLFAVEVRHGDRFLVMRRGGCLVAANLADKPQRVTLPGVARRVLLATAEGVTVTRDRIDLPAETAAIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8S4</accession>
    <name>F4F8S4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_23595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23595"/>
    <dbReference type="EnsemblBacteria" id="AEB45817">
        <property type="protein sequence ID" value="AEB45817"/>
        <property type="gene ID" value="VAB18032_23595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23595"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_1_0_11"/>
    <dbReference type="OMA" id="VFPFEWG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="760"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="29"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="302"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="743"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="842" mass="85879" checksum="025550D809C00989" modified="2011-06-28" version="1">MTPFRRTGGGDPMLRLTLRSMRADLARMLMSTLAVVLGVAFIAGTLIFVDGMRAGAYDRAATFDRHTDVGVYPDPDADTDPDLIDTALVEKVRAVEGVRAAAAELVGTGGVVGADGRPVLGFGVLVAVPADPALQSYDVLAGRLPERAGEAVLDERTVADEGFALGTEVRVGGAGGAAKPYTLVGVVDVADTSRDIGGPFIGLFGPEALAATEQSGYHRILVAAEPGVADEALAARIAEVTGAGTTVHTRAEILDAAVDDAVRDVNQFNMVLLVFTAVAVLVAAFVIANTFTIVLAQRTRRTALLRLVGATRGQVFRATLLESAVLGLVASAVGVLIGIGMAAALSALMNSLDVPLNGELTVTATTVLGSLVVGTALTVGAALVPAWQGTRVAPVAALTDAALQVTRTAGRLRLIFGGLVLAAGVAALAAAGGTGQIALVALGGMLSFFGIVLFGPVLVPALVRMFGVAARRAFGITAALAVANAVRNPRRVAATATALVIGIGLVSSFVVGAHSTKAAIERSVDAQIGVDFVVTGIGGDLPAGVVDALAARPELGVVHEQRSRIVDEGRIRAADPALVERQLESVVAGQAGSFGAGRVLVHRELADERGWSPGDRVDLHGHSFEVAAVVVGPDVGNGPVSPGRVVELVAADFTRLFPDERGYLAEIEPAEGVSAAAAREAIESVLADYPTVNLMDQAAYKRMLTSTVDMLLAFVVALLGLAVVIALVGVANTLSLSVLERTRENAVLRAVGLTRGRMRAMLAVEAVLTALVGALLGVALGTAVTGSAMAMLASLSGGFILAVPWGQLGGILAVAVLAALAASVLPARRALRRPVVEALADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8S5</accession>
    <name>F4F8S5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_23600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734470.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23600"/>
    <dbReference type="EnsemblBacteria" id="AEB45818">
        <property type="protein sequence ID" value="AEB45818"/>
        <property type="gene ID" value="VAB18032_23600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23600"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="MGRFPHV"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="266" mass="28363" checksum="546930CF7CFAAC04" modified="2011-06-28" version="1">MSLAPPVHVTAGVAVTAHGLRKQYGTGEAAVVALDDVDVTFAAGRFTAIMGPSGSGKSTLMHCLAGLDRPTAGTVRIGDAELGRLDDRRLTLLRRDRVGFVFQRFNLLPALSTEENILLPLAIAGRRPEPGWFRQVVAAVGLADRLRHRPAELSGGQQQRVAVARALVTKPWVVFADEPTGNLDSRAGNEVLRLLREAVDTLGQTVVMVTHDPTAAAHADRVVFLADGRLVRDLAAPTAERVLDVLAHLDPGADRAGDAVPSHRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8T7</accession>
    <name>F4F8T7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma-24 subunit, ecf subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_29731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735665.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29731"/>
    <dbReference type="EnsemblBacteria" id="AEB47017">
        <property type="protein sequence ID" value="AEB47017"/>
        <property type="gene ID" value="VAB18032_29731"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29731"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_11"/>
    <dbReference type="OMA" id="VKSRIHE"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="133"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="187" mass="20629" checksum="3ADF0AB87F9FD38D" modified="2011-06-28" version="1">MPDDHDAVERTARAAAGGDRDALEALLAQVRPEVLRLCGRFLPNREDAEEACQDTLLALATGIGSFDGRSSFRTWLYRVAANRSRSTYHALRRRWMVETARALPPERADPARTSVIAGTRLDLLEGLDAIGTDLAEPVALRDVMGLSYREVAQLLGLPEGTVKSRIHEGRRRLRARLTDAGPRSNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8X3</accession>
    <name>F4F8X3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29911"/>
    <dbReference type="EnsemblBacteria" id="AEB47053">
        <property type="protein sequence ID" value="AEB47053"/>
        <property type="gene ID" value="VAB18032_29911"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29911"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042257_1_0_11"/>
    <dbReference type="OMA" id="PRHYGPW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="170"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="353" mass="38035" checksum="CE6170B1564A1E32" modified="2011-06-28" version="1">MVVPPWLSVPPPGYGGLEQVVASLVDALVDRGHEVTLMGAGGEHGTTGDFLATLDELQYDRLGESLPELAHLARVNHLLSAADFDLVHDHSTIGPLVAGRRDVPTLATVHGNPVGEYGTVLSDTDRGVGLVAISHAQRRLNPRLPWVGTVHNAMDIGDFPRKQRPSHGAVLWLARFSPDKGPELAIEACRAAGLPLVLAGKCNEPAERRYYHEVIVPMLGPDVTVVLDADREAVLRLLVEARCLIMPIQWEEPFGIVMLEAMATGTPVVALNRGAVPELVQPGVTGLICERPEELPAALAEAPHLDPADCVAHVARTFSIERMAAGYEEVYRRFLVAATPRSAMREPARITPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Y7</accession>
    <name>F4F8Y7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47067">
        <property type="protein sequence ID" value="AEB47067"/>
        <property type="gene ID" value="VAB18032_29981"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29981"/>
    <dbReference type="HOGENOM" id="CLU_186961_2_0_11"/>
    <dbReference type="OMA" id="MSDKYVD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="56" mass="5726" checksum="F22CE6DEA07C50C8" modified="2011-06-28" version="1">MAENYTDPSGNTQAFRAFAADTTDTPAESSSRTGLIIGVAVLAVLLIAVAGWIALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F978</accession>
    <name>F4F978_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730780.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04900"/>
    <dbReference type="EnsemblBacteria" id="AEB42106">
        <property type="protein sequence ID" value="AEB42106"/>
        <property type="gene ID" value="VAB18032_04900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04900"/>
    <dbReference type="eggNOG" id="COG2910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_3_0_11"/>
    <dbReference type="OMA" id="GDFDHEG"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="207" mass="21837" checksum="7F167D0010E2A05C" modified="2011-06-28" version="1">MNIVVFGAGGRAGRQVVAEARRRGHQVTAVVRDPARHNNLADVRIVAGDVTDAVSIAAVAAGHDAAISAAVDLSVSPHDFFTASSRALATGLAKAGVRRLVVVGLASIMPGASGAALMDEPGYPNEYRSFYLGHAAGLEELQTCDLDWAYMAPAGDFDHEGTRTGHYRLADHGDAASRISYADFAIALLDEIEAPRHHRVALSVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F994</accession>
    <name>F4F994_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10850"/>
    <dbReference type="EnsemblBacteria" id="AEB43288">
        <property type="protein sequence ID" value="AEB43288"/>
        <property type="gene ID" value="VAB18032_10850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10850"/>
    <dbReference type="eggNOG" id="ENOG502ZUHE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193835_0_0_11"/>
    <dbReference type="OMA" id="HGTCHCG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="72" mass="7907" checksum="B451392373471CA3" modified="2011-06-28" version="1">MSGPTGMLTGDRVYRIHWMPGTDILRGVCHCGAERVAEEPVELWEWLLAHPQGHRSPAPPAPELPTRTAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9B1</accession>
    <name>F4F9B1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rok family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731976.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10935"/>
    <dbReference type="EnsemblBacteria" id="AEB43305">
        <property type="protein sequence ID" value="AEB43305"/>
        <property type="gene ID" value="VAB18032_10935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10935"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="OMA" id="PRWHRGL"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="391" mass="39959" checksum="F46C10115CA9059B" modified="2011-06-28" version="1">MSATRLPGTPRLLRALNDRAALELLLEQGPLTRARIGELTGLSKVTASQLVERLEERGLVTRVGEQAGGRGPNAQLYAVRPGSAYVVGVDVGPERVVAACADITGTVAGRVEQSTKDTDDPVGVVHNAVVQAASSAGAQLSSVRRIVLGTPGLVDPGTGDITFAFNLPRWHRGLLAALRDDLDTPVVFENDVNLAAVAEAQSGAAQGMSDFVLVWIGAGVGLAIMLGGRLHHGSSGAAGEIGYLPVPGAPIPRDVSRRAKPAFQQVAGADAILALAREHGYPDGGAAEAVKAAIAAGTAGGPMLDEVARRLALGVASTCVVLDPPLVVLAGEVGQAGGAALAERVQHEVAAITLVRPRVVPTGLPEEPILRGALRTALDAVRDEVFGSTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9L9</accession>
    <name>F4F9L9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733252.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17475"/>
    <dbReference type="EnsemblBacteria" id="AEB44597">
        <property type="protein sequence ID" value="AEB44597"/>
        <property type="gene ID" value="VAB18032_17475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17475"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088572_1_0_11"/>
    <dbReference type="OMA" id="IEQFGEH"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041484">
        <property type="entry name" value="TetR_C_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17933">
        <property type="entry name" value="TetR_C_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C_25" evidence="2">
        <location>
            <begin position="98"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="230" mass="24591" checksum="CC98910356430E34" modified="2011-06-28" version="1">MASREVSSDKHGGEFATVGRIRDAAIARFARDGFRVGLRALAADAGVTAGLIVHHFGSKDGLRRACDSHVLAVMREQKAKVLTDGTGATLLAQLAEVEQYAPLVRYLLRSLQAGGELAATLIEAMVADAEAYLSAGESAGVIKPSRDGAARTRYLAYQATGSMVLWFTLHGADAAPEEFAHLFRRYMDDFALPALELFAEGLLTDRSMLDEYLMYVPDPPSPGDADTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9N4</accession>
    <name>F4F9N4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17550"/>
    <dbReference type="EnsemblBacteria" id="AEB44612">
        <property type="protein sequence ID" value="AEB44612"/>
        <property type="gene ID" value="VAB18032_17550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17550"/>
    <dbReference type="eggNOG" id="ENOG50346BK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141456_0_0_11"/>
    <dbReference type="OMA" id="SRIACMA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045770">
        <property type="entry name" value="DUF6223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19733">
        <property type="entry name" value="DUF6223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312828" evidence="2">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="137" mass="12596" checksum="F83410311EE1E188" modified="2011-06-28" version="1">MLTVTAAAVIGVVALAVLLGATGLGGPATADGPAAAIDGYDLTTGRLVGLVGALAALAGVVVGGLAVTRPRSRIGTGRLGATIALVAGLIGVVLGGYVVAAAEGGPGTGYGIVGGVVALVVGLASLGLGGLAMARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Q2</accession>
    <name>F4F9Q2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_23650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734480.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23650"/>
    <dbReference type="EnsemblBacteria" id="AEB45828">
        <property type="protein sequence ID" value="AEB45828"/>
        <property type="gene ID" value="VAB18032_23650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23650"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_21_1_11"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB45828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="566" mass="61176" checksum="13AF2FFC9EE8CFCB" modified="2011-06-28" version="1">MSSTPVLPDPSTEPPAFADLGLRSELLAALSALGYEEPTPIQREAIGPLLAGRDLLGQAATGTGKTAAFALPLLQRMPDERPTGDPVALVLVPTRELAVQVSEAFHRYGKDLGARVLPIYGGQPIGRQLRALDNGVDVVVATPGRALDHIARGTLRLGNLATVVLDEADEMLDMGFAEDIEAILEHTPEQRQTVLFSATMPSRIDGMARAHLTDPVRILIAREQPVAGEAPRVRQSAYLVARAHKPAALGRVLDVESPTAAIVFCRSREEVDRLTETMNGRGYRAEALHGGMSQEQRDRVMGRLRGGTADLLVATDVAARGLDVEQLSHVVNYDVPSAPESYVHRIGRVGRAGREGVAITLAEPREHRMLKTIERVTGQRITIDKIPTVADLRTRRLELTQAALRESLLEDDLDPFRVIVETLSDEFDLMEVALAAVKLAHEATLPGAEEAAEEIPQVAVRAPRETRPGADARGGDRRPARPRANGTTQVFIGLGRRAGVRPQDLVGAITGETGIRGRDIGSIEIADRFSLVEVPIAVADEVIAGLRGSTIKGRKATVRRDRDDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9V0</accession>
    <name>F4F9V0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhs element Vgr protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734528.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23890"/>
    <dbReference type="EnsemblBacteria" id="AEB45876">
        <property type="protein sequence ID" value="AEB45876"/>
        <property type="gene ID" value="VAB18032_23890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23890"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520553_0_0_11"/>
    <dbReference type="OMA" id="HTFTESE"/>
    <dbReference type="OrthoDB" id="1880900at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="2">
        <location>
            <begin position="351"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="531" mass="55082" checksum="20D32787F35F63AE" modified="2011-06-28" version="1">MTGVGPRALIVLLDGVALAEALTGQLRTVRVAARLNRPTQCEAVLAAGPGTAALSTPVRLGVSLEVRLDGQPETLFRGEVTAVEVEYAADGAATLRVRAYDPLHRLRKRQRLRVFESVTVAELAGDLCADLGLRVDAQCDGPRLERLAHHRASDLDLLLAVAGRAGLHLTVQDDVLRLVTLQGDGDPIPLELGHHVHGLRLSVNADTAAGESTALGWHPQRAEPIAQSAGTPRCGRRTPVEPDPADVGADGARTALDQPGRSDDEIAALAQARLDVRAAALVTAEGTAEGDAALRPGRRVRLTGVAEAVAGTYVLTEVVHTLDADGHLTRFSTVPPPAPPAGPPAPAVVTLGTVTDVADPDGLGRVRVELPAYGGADAGWLGVLCPGAGRGKGLVALPDPHDSVLVALPGGEPASGIVLGSLFGAVEPYDAGIDDGRARRWSLRTAGGQQVVIDDVARSLRLSTDAGSWLELTPDLATLHAATDLVLSAPGRAMVVRARSVDFLHAETVEDPDTAAEQARTLARAHHEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA33</accession>
    <name>F4FA33_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00300"/>
    <dbReference type="EnsemblBacteria" id="AEB47144">
        <property type="protein sequence ID" value="AEB47144"/>
        <property type="gene ID" value="VAB18032_00300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00300"/>
    <dbReference type="eggNOG" id="ENOG5031QBT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133066_0_0_11"/>
    <dbReference type="OMA" id="VEVFWLP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="15462" checksum="B2DE46D0B508E34C" modified="2011-06-28" version="1">MTSPAAMSVAPQEQLPQPPRSARVSRFLDVGLRVAGGVVVVVAGAVTAVLELLLAPLRIGGHLVGLAALVAVVVNVALSWFAIEAVGRRWAVALPAVPWVVIMVAAADRTNEGDVLLIGNWVGLILVVAGVMAFAVMAFRAIVAGPTASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA67</accession>
    <name>F4FA67_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase/ thiol specific antioxidant/ mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730802.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05010"/>
    <dbReference type="EnsemblBacteria" id="AEB42128">
        <property type="protein sequence ID" value="AEB42128"/>
        <property type="gene ID" value="VAB18032_05010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05010"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013730_1_0_11"/>
    <dbReference type="OMA" id="IAMAGVH"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="611" mass="64990" checksum="5E470A5FD727AF06" modified="2011-06-28" version="1">MSARVRAPELRGRGWLNTGGRELTLADLRGKIVIADFWTFCCINCLHVLDELRPLEEKYADVLVVIGVHSPKFEHEKDPVALADAVERYGVHHPVLDDPELDMWQQYAARAWPTLAVIDPEGYVVATMAGEGHAEGLARLIDDLVATHEAKGTLHRGDGPYVPPAEPQTTLRFPGKLVVGPDGTLLVSDSARHRVVELAADGETLLRAIGTGSRGRVDGTADTATFSEPQGLCLLPPHVAEVAGYDLVVADTVNHLLRGVRLGSGEVVTVAGTGRQWRSTVDDHAHDALSVDLSSPWDLAWYDDKVVIAMAGIHQLWWFDPIKRTAGMYAGTTVEALRDGPLAETWLAQPSGLAVSADGRRLWVADSESSAIRYVEDDVMGTAVGQGLFDFGHVDGPAAQALLQHPLGVCALPDGSVLIADTYNGAVRRYDPATDEVSTVATDLAEPSDLALTPDGAVLVVESAGHRITRLAPGALSAVGASTVDGPRHRTERKPTDLAAGEVTLDVIFTPAPGQKLDETYGPSTRVMVSASPPELLVEGAGTSTDLSRRLVLSDSVTEGVLQVTAQAATCDADVEHAACHLTRQDWGIPVRVATGSATRLPLVLRGLDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAB7</accession>
    <name>F4FAB7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amp-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730852.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05260"/>
    <dbReference type="EnsemblBacteria" id="AEB42178">
        <property type="protein sequence ID" value="AEB42178"/>
        <property type="gene ID" value="VAB18032_05260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05260"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="OMA" id="EVSWATI"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="434"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="521" mass="56495" checksum="BC2B8178C1601883" modified="2011-06-28" version="1">MELPFIVATLTRRGLLAPGRPIRVASQLNALRTWGWSLAGELRQAAARDPDRIAIIDDQGTELTYADLLERSLRLARALRAGLGVAAGDRIGVFGRNHPGLVETIVAATLLGADAVLINTGLSPAQLTTVAEEQRLRVLVHDDEFAERLLGLPADLHRVDERAREDLIRTALPGQLDPPDRDGRIIVLTSGTTGTPKGARRPTPTGFGPLVAIIDRIPLHVRDRVMIAAPVFHTWGYAALQVCLALRATIVLHRRFDPAATLDALVRHRCQALFAVPVMLQRLMEVPPPDPRPPLKIVAVSGSALPGGLPSAFMDRYGDVLYNLYGSTEASWASIAVPADLRQAPTTAGRPPHGTRLAILDDDGRPVPTGQVGRVFVGNEMLFEGYTSGADRERHDGLLDTGDLGRLDADGRLFVDGRADDMIVSGGENVFPAEVEHLLAQLPQVREAAVVGVPDPEYGQRLAAFLGLYPGETLDADAVREYVRHYLARFSVPRDVVFVKYLPRNATGKVLTGELRDYITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAC4</accession>
    <name>F4FAC4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730859.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05295"/>
    <dbReference type="EnsemblBacteria" id="AEB42185">
        <property type="protein sequence ID" value="AEB42185"/>
        <property type="gene ID" value="VAB18032_05295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05295"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787368_0_0_11"/>
    <dbReference type="OMA" id="GRDWAWM"/>
    <dbReference type="OrthoDB" id="1712291at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="36115" checksum="FB08043EAFC30AED" modified="2011-06-28" version="1">MTTAEAIRLVGAARDDEELFGVDAPERRYRELVAALHPDRLSLAGPGLQAEATAAFVEVTTRWRSRHVTELNGYRCGRPAHCGDLADLYDVGDDRLLKLPRAANDNDLMLQEERALRRLAEHGDPRWLPYVPRLVDSFAHRDAATGAERRINVIATAPRLHSLVEVRRAYPDGLDARDVAWMWRRLLVALGLAHRAGLVHGAVLPPHVLIEPDAHGVVLVDWCFSTDTGGVVPALVPDYQDWYPPEVTGRHPAGPGTDIAMAVRCMDWLMGRHAPAELRAFVNGCQQPQLAARPDDAWRLLGELDEVLERLYGPRTFRPFTLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAF3</accession>
    <name>F4FAF3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, iclr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_11310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732051.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11310"/>
    <dbReference type="EnsemblBacteria" id="AEB43380">
        <property type="protein sequence ID" value="AEB43380"/>
        <property type="gene ID" value="VAB18032_11310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11310"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_4_1_11"/>
    <dbReference type="OMA" id="EPDRLHR"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="63"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24256" checksum="1B3CAD4FBB4EE16F" modified="2011-06-28" version="1">MSGVGVLDKAVVILAACVDGASLAELVERTKLPRATAHRLAQALEIHRMLVRDTQGRWRPGPRLGELANAAPDVLLTAAEPLLAALRDATGESAQLYLRRADERICVAAAERASGLRDTVPVGSVLPMTAGSAAQILLAWEPPEAVMPLLPRSKFTGRTLAEVRRRGWAQSVAEREPGVASVSAPIRDRTGRVIAAISISGPIERLGRRPGERHAMAVVRAGQRLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAS4</accession>
    <name>F4FAS4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733344.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17935"/>
    <dbReference type="EnsemblBacteria" id="AEB44689">
        <property type="protein sequence ID" value="AEB44689"/>
        <property type="gene ID" value="VAB18032_17935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17935"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065561_0_0_11"/>
    <dbReference type="OMA" id="WNVSMVI"/>
    <dbReference type="OrthoDB" id="489714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="80"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="370" mass="40878" checksum="980EA2256913E48D" modified="2011-06-28" version="1">MSEMLRAPAEVKYADELDYLESVDTGPKPYSWRLSPRMIRLFVLGSERADGLDREIPQKWFGDRSFVERSIVTLASDRGLLLIGDPGTGKSWLAELLSAAICRNSTLVVQGTAGTTEDHIKYSWNVSMVIAKGQSRESMIPSPIMTAMEQGVIGRFEELTRSTSDVQDALISILSEKYVSIPELNDDNIVFAKPGFSIIATANSRDRGVNDLSSALKRRFNFVRIPVVTNKRSEAEIVRFRTEELLRRHHVELEVPPTLLDILLQSFADLRAAATSATSDDEKLESALSTAEQIGVLEDAILHSQFFGDRTLRAGTLAGSLVGSLARRSPEDLAILNKYLHAVVEPRAKQDGGEWNDFLDGGRQTIAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB05</accession>
    <name>F4FB05_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734620.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24350"/>
    <dbReference type="EnsemblBacteria" id="AEB45968">
        <property type="protein sequence ID" value="AEB45968"/>
        <property type="gene ID" value="VAB18032_24350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24350"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063235_0_1_11"/>
    <dbReference type="OMA" id="VTPRTGW"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="233"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="35271" checksum="DCF72A52F3545547" modified="2011-06-28" version="1">MSIWRVPVDLLARSRFAVSPMTDTVAALRALHSPRRPWQHAWRRPHLGAYQQMLTRRPTLRALLAAAFQPRWTADFLTLAPATAAPSFAEELAVVAGRGDAQVRDDLRVCRPGPLPDTLCADGLTEQVVFLLDWVWTHTVQPEWPDRRRRLLADIVARTARLSAEGWAGAVAGFDPEMRWLGDGWLRVNDYPAAPLPLDRAEQLVFVPAHCARGWVLWDQPTRFGMVYPASGILADTAPPVPDGLDRLIGANRAAILVRLATPLSTSQLASVTGLSLGSVGDHLRVLLDSGLVTKRRSGREVLYWRTPRGTILCGPATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB71</accession>
    <name>F4FB71_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nudix hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00660"/>
    <dbReference type="EnsemblBacteria" id="AEB47216">
        <property type="protein sequence ID" value="AEB47216"/>
        <property type="gene ID" value="VAB18032_00660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00660"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873278_0_0_11"/>
    <dbReference type="OMA" id="GEDPNHT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="147"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="292" mass="31266" checksum="53467CC10621573B" modified="2011-06-28" version="1">MLLVRASERSGTPGTWSLPGGAVDHGEDPQHTVVRETAAETGLSVSVASLQDVLADMRALPERGITIHTDRLVYQVSVRGGSLTDRVDRPTDLARWFTREEARQLPLRSFTARALGLPTSSADIVPDEPPEFPSFYAVPGPDGLHRAQRFAAYAVVTDPDGRVLLTRVSDGYPGAGCWHLPGGGTDYGEQPGAALIRELVEETGQTGRLIGLLGVASHRDAASLGPEGYPIDWHGVRAFYRVVVDKPAPPTVADVGGSTCEARWFAREELGALPTDRLTEVTAEAVQAARLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBB8</accession>
    <name>F4FBB8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730887.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42214">
        <property type="protein sequence ID" value="AEB42214"/>
        <property type="gene ID" value="VAB18032_05440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05440"/>
    <dbReference type="eggNOG" id="ENOG5031M1Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131923_0_0_11"/>
    <dbReference type="OMA" id="DKRWVAR"/>
    <dbReference type="OrthoDB" id="1654344at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="129" mass="13316" checksum="D866721A1AA637F5" modified="2011-06-28" version="1">MTDSPQQTFADATAILSSALDGDSDAVVGTFDAVVDRDGLTGAYDVAWCLAATMVGDPVPPGACALDFPGIDQAEYDARWVARFVSAYANSDLETARALFGAAAADGLLPECLLTLAGSTIATLRHRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBR3</accession>
    <name>F4FBR3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733368.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18055"/>
    <dbReference type="EnsemblBacteria" id="AEB44713">
        <property type="protein sequence ID" value="AEB44713"/>
        <property type="gene ID" value="VAB18032_18055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18055"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_1_11"/>
    <dbReference type="OMA" id="EVEWHDP"/>
    <dbReference type="OrthoDB" id="1938042at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="168" mass="17183" checksum="8C942E1A9D2BEBCD" modified="2011-06-28" version="1">MNDQEASLDQLRRTAAALLELSPHPPSGLRLRTGDLSVEVDWAQPAGPAGTPAIATSGVAPAAVAALSAVSDAVAAVRAPLLGTFYRASAPEAPPFVALGDRVEVGQQIGIVESMKLMNPVESDVAGEVLEVLVADGAPVEYDQVLLMVATDRAVDGCAQIFGGKDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC19</accession>
    <name>F4FC19_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734669.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24595"/>
    <dbReference type="EnsemblBacteria" id="AEB46017">
        <property type="protein sequence ID" value="AEB46017"/>
        <property type="gene ID" value="VAB18032_24595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24595"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873440_0_0_11"/>
    <dbReference type="OMA" id="KLFHWAV"/>
    <dbReference type="OrthoDB" id="1308935at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="32611" checksum="FBDE69E2451CFE42" modified="2011-06-28" version="1">MAHLDSREALPINATKTRPPVRATIIAVLGGILLAVVWSFELVDSVIGDTVANAALGHDAKTTPIAGTAAGLLFAFVSGLAGTFTACNIAMMASVGPLTQASTERTGMARHTVAALLRPVGWMTVGMVAVSAVYGAVGVMLGDRLPQLSTEVVGEMPVRLIQSSVVFGLIGLALAYLGLAALGILPDVFARRPVARVVTIGALIGGFLIGRPYPLFNKLFHWAVDTGNPLNGALAFVLQSLGNILIVAVLFAIIVLVTRGRFLQWASDPSRSAVVTGGLMLMLGVFTVVYWDLRVPAMFGVGWFPMMPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC82</accession>
    <name>F4FC82_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_00885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735906.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00885"/>
    <dbReference type="EnsemblBacteria" id="AEB47261">
        <property type="protein sequence ID" value="AEB47261"/>
        <property type="gene ID" value="VAB18032_00885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00885"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_1_1_11"/>
    <dbReference type="OMA" id="HDKHRIA"/>
    <dbReference type="OrthoDB" id="1635544at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="13063" checksum="2872DCE3DD7402BA" modified="2011-06-28" version="1">MDPRRDPRGALVRPYAVTRGRTEPLQDIALEAVLIASPTQIAESRFAGHDKHRIAMVCEGRPESLAEIAAYTRLPLGVARVLVADMVADGLLTLQTAAPATGFEERMEMLGRVLSGLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCA3</accession>
    <name>F4FCA3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735926.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00990"/>
    <dbReference type="EnsemblBacteria" id="AEB47282">
        <property type="protein sequence ID" value="AEB47282"/>
        <property type="gene ID" value="VAB18032_00990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00990"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OMA" id="GQQARFQ"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="321"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="263"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="559" mass="60846" checksum="975F20003F9A0414" modified="2011-06-28" version="1">MGYVDVAAVGYVLPDGRELFADVSFRVGEGAKVALVGPNGAGKTTLLRMVAGDLPVRTGTVARTGGLGVMRQFIGMIGDESTLADLALSLAPPPLREAGRRLAETEAAMRAAELRGKYSSAAGKAQLAYADALAAWGETGGYDAEVLFDTVATIVLDLPWDTARQRPVRTLSGGQQKRFALELLLRGTDEVLLLDEPDNFLDVPGKRWLEARLRESGKSVLYVSHDRELLAHTADRVVAVEGGGAWVHPGGFASWHEARVARHARLDEQRRRWDEEHQKLRELMLMYKQKAAYNDGLASRYQAAQTRLRKFEEAGPPPVPPKDQDIRMRLTGGRTGKRALVCEQLELDGLTYPFDLEVWYGDRVAVLGANGTGKSHFLRLLARGGTDPDPANPPVDGAAALAPVAHGGVARLGARVRPGHFSQTHDRPELMAKTLVEILWRGDEHRDGMDRHAAMAALSRYELAGQGDQRFGTLSGGQQARFLVLLLELSGATLLLLDEPTDNLDLASAEALEAGLAAFAGTVLAVTHDRWFTRTFDRFLLFRGDGEVVETDEPVWDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCA4</accession>
    <name>F4FCA4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase small</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00995"/>
    <dbReference type="EnsemblBacteria" id="AEB47283">
        <property type="protein sequence ID" value="AEB47283"/>
        <property type="gene ID" value="VAB18032_00995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00995"/>
    <dbReference type="eggNOG" id="COG2813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_7_0_11"/>
    <dbReference type="OMA" id="HMIDVNE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="32"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="21986" checksum="B352FF0A21E53B1F" modified="2011-06-28" version="1">MTGVTGDHYFTTAPSASAQPREVQFAVAGRDFTLASASGVFSATRLDPGTAVLLRKADLPPATTEGALLDLGCGFGPISCVLATVAPTATVWAVDVNERARELTAANADRLGLADRLRVAPPEDVPADLTFAQIWSNPPIRPGKDELHALLLRWLPRLTPDGVAWLVVGRHLGGDSLHRWLVEQGWQVQRHASQKGFRVLRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCA6</accession>
    <name>F4FCA6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ordered locus">VAB18032_01005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735929.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01005"/>
    <dbReference type="EnsemblBacteria" id="AEB47285">
        <property type="protein sequence ID" value="AEB47285"/>
        <property type="gene ID" value="VAB18032_01005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01005"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_2_11"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="152"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="30470" checksum="E005F9DFFAEED32E" modified="2011-06-28" version="1">MDERVRLRLDVAYDGTDFSGWAAQPDRRTVAGVLVQTLDLVLGAGTATGLTVAGRTDAGVHASGQVCHLDLPVEVWREHEGRLLRRLARLLPGDVRVRAMTEVPATFDARFSATFRRYEYRVTDAPWGAEPLRRHEVLAWPRPLDTDRLAAASAGLVGEHDFAAYCRRKENATTLREVTRLDWRRDPDGILVATVQADAFCQAMVRSLVGAMLVAGDGRRPVEWPAGLLTRRERSSEVTVAPAHGLTLVAVGYPDDPAEYARRAEATRRLRVPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCF8</accession>
    <name>F4FCF8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma-factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730958.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05795"/>
    <dbReference type="EnsemblBacteria" id="AEB42285">
        <property type="protein sequence ID" value="AEB42285"/>
        <property type="gene ID" value="VAB18032_05795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05795"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026775_0_0_11"/>
    <dbReference type="OMA" id="TQVAQHI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025751">
        <property type="entry name" value="RsbRD_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14361">
        <property type="entry name" value="RsbRD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="158"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="286" mass="30726" checksum="D9547043A1E6B1C6" modified="2011-06-28" version="1">MALSADESSRLAGLLTSHVDQVTQRWTEVVAGQLRGRLSQAELRQQVQELHRALVDALGKGLTDLAAEEATELRAVLAEMSRGQARQGFSAAETATGVFALKDALLSVMEADQSAGTLRDYVAFGTLVDQMGLFTFESYVRTRESLIADQAEQLLELSTPVVKLWEGVVAVPLVGTLDSARAQVVMERLLQTLVDTGSPYAIIDITGVPAVDTQVAQHILKTVVAARLMGADCIISGIRPQIAQTIVALGIEFGDIATKASLADALRHVLRLTGVETGRRQPRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCI6</accession>
    <name>F4FCI6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_05935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730986.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05935"/>
    <dbReference type="EnsemblBacteria" id="AEB42313">
        <property type="protein sequence ID" value="AEB42313"/>
        <property type="gene ID" value="VAB18032_05935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05935"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="OMA" id="EDCWFIA"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="16263" checksum="F565F078089FA9E6" modified="2011-06-28" version="1">MDAIDLALVDLLRGNARLSYAELARQVGLSAPAVHERVGKLEAGGVIRAYRAEVEPETIGLAVTALISVVEDSGADTDDVLEAIRAMPEIESCYFMAGVESFLLKARVSTIAELEQLIVRLNRTPGVASTRTSIALSTKWENRPQPVGPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCU5</accession>
    <name>F4FCU5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malic protein NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_12375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732258.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12375"/>
    <dbReference type="EnsemblBacteria" id="AEB43589">
        <property type="protein sequence ID" value="AEB43589"/>
        <property type="gene ID" value="VAB18032_12375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12375"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_11"/>
    <dbReference type="OMA" id="RTVNTEM"/>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="4">
        <location>
            <begin position="95"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="3">
        <location>
            <begin position="240"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="490" mass="50867" checksum="CF52786690237536" modified="2011-06-28" version="1">MAITRLPSAGFSITVRIAVPADASSIGRLTTSVGEAGAIVTALDVVDSDPNHVIVDLTCDTADAGHADQVVDALRALDGVDVRKVSDRTFLLHLGGKIEVSPKVALRTRDELSRAYTPGVARVCQAIADNPADARRLTIKRNTVAVVSDGSAVLGLGNLGPAASLPVMEGKAALFKRFGGVDAWPVVLDTQDTDEIVAIVKAIAPAYGGINLEDIAAPRCFEIEARLREALDIPVFHDDQHGTAICVLAALTNALRVVGKRLADVRVVVSGAGAAGTAIMKLLLRQGVGDVIAYDRQGALHRGQPDLNSAWQWLAENTNRDGYSGDLPGALEGADVFIGVSAPNLLTGDDIARMAKDSIVFALANPDPEVDPREARKHAAVVATGRSDQPNQINNVLAFPGVFRGMLDAHAEEFTEEMAIAAAQAIADVVGEEKLNATVIVPSVFDSRVAPAVAAAVRAAAQNPASTPPPAADPGPADLPEIAANASATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD45</accession>
    <name>F4FD45_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734727.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24885"/>
    <dbReference type="EnsemblBacteria" id="AEB46075">
        <property type="protein sequence ID" value="AEB46075"/>
        <property type="gene ID" value="VAB18032_24885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24885"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_4_11"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="78" mass="8749" checksum="D36F787569715721" modified="2011-06-28" version="1">MPNTLEKVSEIVLEQVPDVEVAIGPNLRISQDLGIDSLTFVDILVKIEKVFDVEFSDNELATVQSVQDILDLVEHKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD80</accession>
    <name>F4FD80_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25060"/>
    <dbReference type="EnsemblBacteria" id="AEB46110">
        <property type="protein sequence ID" value="AEB46110"/>
        <property type="gene ID" value="VAB18032_25060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25060"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012121_0_0_11"/>
    <dbReference type="OMA" id="WPEVLFD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="472"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="760" mass="78942" checksum="FD774CABB727AAD9" modified="2011-06-28" version="1">MGRGAPVVRLLRAVPVPAALVGMVVLAGVTLDRVYAGSLLTALVAGAALGSVLVSVAARRLPSWLVAPVSVLVMAGWTAWCLRLTADRAGLPGGFAQVAADAAGNGIPRLLTAMIPVEPTPDTVLVPLVGAWLAGLAGAEVALRAGRVLLGYLPPVLLHIGAVYVVGPNAEPAIGPTVALVVLAGLGLAASARRGDDPLDTLAPAVRSRVRARLAVASAAGTAVVVAAATLLGPAVAALVEVRPVDPRRYVEPPQVETLDENPLIRISGWALRPDQQLFQVRTEAGGGNRIRLAVLSDYDGVTWRVGATYRNAGRILPTVQPATYATVETVRQEITVDELSGRLLPAVATPREVTGARVAYDPGTGTLIRPDGLSPGLRYTVISARERPDANLLATANTPVGDEVARVLHVPDGAPDQLRRLAAQLAEENGAPYARAAAIEQWLAEHYRLVADAPSGHAYPNLAFFLFGPRNGGGQRGTSEQFAASFAVLGRLAGLPTRVVVGFAAPGDGPVRAGDAYAWPEVLFDGVGWVPFDPLPRPDDEPRPVEEDFRPQPEKPPPSEQPEPTVEPSASSAPPASAEGGDDQAGLSTPMLAAGATAGFLLLVVAALATLAGLRRALTRNRLHRGPADLRVAGAWRELTDALRLAGRPVPTDLSATEVADAARRALSAASPAAPSEVAGSPVAGAGPAGHQSVAAYRAVDDLARLVNQVGFAPGQVTDAQVDAAADAATRYTGALRAARSRWRRLLWSVHPGPLRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDI1</accession>
    <name>F4FDI1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_01540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01540"/>
    <dbReference type="EnsemblBacteria" id="AEB47392">
        <property type="protein sequence ID" value="AEB47392"/>
        <property type="gene ID" value="VAB18032_01540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01540"/>
    <dbReference type="eggNOG" id="COG3883">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073856_0_0_11"/>
    <dbReference type="OMA" id="QIWMPST"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312932" evidence="3">
        <location>
            <begin position="32"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="334" mass="35843" checksum="222C7CFAE5ACB97C" modified="2011-06-28" version="1">MPVRRRLHRPLITLLAAVALLLGVGAVPAYAEPNEGGSKKLRDTLEATAKAHIEAKRKLDSSKKRQKKMAKELSELEGRLSELSVMVGEVAAQSYRIGRLSAAAALLDSGTPEAFVQRAASLDMMAQRDGRRVRELTEAREQARQAKLAINAEVREQTKQLAVIAKKKKETEAALAAVSSGTSGGFSGGSATSAKPAPRNANGSWPSESCSVNDPTTSGCITPRTLHALQQTKAAGYKRYVSCYRSGGSGEHPKGRACDFSAATNGFENRTATGGDKAYGDSLAAWHVRNADRLGVLYVIWYRQIWHPGTGWRAYGGSGSPAADHTNHVHLSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDI5</accession>
    <name>F4FDI5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver modulated serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01560"/>
    <dbReference type="EnsemblBacteria" id="AEB47396">
        <property type="protein sequence ID" value="AEB47396"/>
        <property type="gene ID" value="VAB18032_01560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01560"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035411_0_0_11"/>
    <dbReference type="OMA" id="VELRIAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="378" mass="40687" checksum="DFDB300927ED7AB6" modified="2011-06-28" version="1">MLLVEDDEGDAFLVGELLAETNSGIDLLVATSLSEARRRMAGVDCVLLDLGLPDAQGLDGLRQVLEMSGSAAVCVLTGRSDEHLGIVAVAEGAQDYLVKGQVDGVLLTRALRYAVERKRADENARRLREVELRQAESARLERGLLPQPLMSTDKIAVHTFYRPGRHAALIGGDFFDVVQTRPDQVDLIVGDVCGHGVDEAALGVELRVAWRALILAGVPDDEVLPALEQVLMSERRLQEIFATVATVRLDLDANRGTVRLAGHPPPVLLAGGKVAPVPAPGGLLLGVRPRRPVAFDLEFDTEDWSLLMYTDGLIEGRVGEGDERLDVPGLTRLLQEPDSRHVALPALPAWLVGRAEQLNGGPFADDVAMLLVTRGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDM2</accession>
    <name>F4FDM2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06305"/>
    <dbReference type="EnsemblBacteria" id="AEB42385">
        <property type="protein sequence ID" value="AEB42385"/>
        <property type="gene ID" value="VAB18032_06305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06305"/>
    <dbReference type="eggNOG" id="ENOG5033A2X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116311_2_1_11"/>
    <dbReference type="OMA" id="GICALSM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="122" mass="12187" checksum="5D8DBB9A604658EB" modified="2011-06-28" version="1">MTGRRLAGRDRGSFTAEMAAGLPALLLFLLTGLTAVNAVGTKSACLDAAREAALAASRGEDGTRAGNRYAPPGASVTVVVEGELVRATVRAPVRVLGGDLPVITVVGGAVAVAEPGVPEPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE65</accession>
    <name>F4FE65_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminopeptidase S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_19160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19160"/>
    <dbReference type="MEROPS" id="M28.003"/>
    <dbReference type="EnsemblBacteria" id="AEB44934">
        <property type="protein sequence ID" value="AEB44934"/>
        <property type="gene ID" value="VAB18032_19160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19160"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_2_1_11"/>
    <dbReference type="OMA" id="DHASFKN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312958" evidence="2">
        <location>
            <begin position="29"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="3">
        <location>
            <begin position="325"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="499" mass="51123" checksum="9D5615A48F55010A" modified="2011-06-28" version="1">MRACTALVLTAVAVVAVPATAPATTAAATASVVSAMAVPDISLTNTKAHLQQFQTIATSNGGNRRATSAGYTASVTYVYNKLVAAGFTVTRQNCTSGCTSGAGPNVIADWPGGGDPNSIYMFGAHLDGVSAGPGINDNASGSATLLEIALTLAATNPSLTSRVRFAFWTDEEQGLNGSRFYANTLSSTERAKIKAYFNFDMVGSVNGGYFINRITSVPGQTLKAYYDSIGVPTEENTEGAGRSDDAPFNAIGVQTSGVAAGASRVKTAAQVTKWGGTQSAFDPCYHRACDTYPSNISDTVLNRAGDAAAYALWTLAAGTPATTVWSDTFETATGWTTNPAGTDTATSGSWERGVPQATNSSGAKQLTALSGTNDLVTGRLAGTSAGDHDIDGGTTSVRSPAITLPTTGPLTLKLSWYLAHGSNATSADFFRVSVVHNGGTTALFTQSASATNRNAAWTSGSWSLSSYAGQSIRILIEAADAGTASLVEAAVDDVVITQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE83</accession>
    <name>F4FE83_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25255"/>
    <dbReference type="EnsemblBacteria" id="AEB46149">
        <property type="protein sequence ID" value="AEB46149"/>
        <property type="gene ID" value="VAB18032_25255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25255"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899417_0_0_11"/>
    <dbReference type="OMA" id="WHALAKI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="35200" checksum="00C5648BFE955E88" modified="2011-06-28" version="1">MRFVTYNLLDLTLTADNLREANRQQRVIDTIRSLEPDVVAVQELKSPPASAARLAAELADRTGLTSTVATNGSARAIHAVAVGDHTVHTALLWRPGLTPLPHTFRTYSPAVHYDGGWRGIGYGSMVRLAFQIDGQPITFASYHAPAYGRHRRIDQAEAVLAALTRPHELALIGSDFNSIGAARTNGADYDPDPYTGRPWWPDLVHQCHEPTHPSQRHRADRRPAQVWEAGGLHDVAAATRSPWKATTGHWPTCPYGVRGIARRVDTIHATQPVLRAVRSLTVVDNPTTRAASDHLPVTVDLDPRKLAVNPGDSRQVGQRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEK1</accession>
    <name>F4FEK1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5667 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736078.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01795"/>
    <dbReference type="EnsemblBacteria" id="AEB47443">
        <property type="protein sequence ID" value="AEB47443"/>
        <property type="gene ID" value="VAB18032_01795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01795"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061725_0_0_11"/>
    <dbReference type="OMA" id="HDASEGH"/>
    <dbReference type="OrthoDB" id="1505856at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043725">
        <property type="entry name" value="DUF5667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18915">
        <property type="entry name" value="DUF5667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5667" evidence="2">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="29596" checksum="7EED9BB13F9969BB" modified="2011-06-28" version="1">MDNALFSRRRAERFAQLLDEANGGRRHHVRSRVDDRLTPLVGLGRQLTAGPPEPEVDPEFRAGLRAMLLATAEREGIAAPASTEKVGTGRGALLPAVTARRARARGAILVGIAAGAIAVSGISAASENAVPGDALYGMKRGTERAQLALASSEISRGQLFLDFARTRLAEASALHGSRSGYGAVLDDMDADTRQGVRLLTAAAVQRSDPAALDAVDAFLVPQRRALDALRDSGSRADRERTAQSLKLLASVTERGDALRTTIACGQPVGSASDSLGPLPGTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEM3</accession>
    <name>F4FEM3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_01905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01905"/>
    <dbReference type="EnsemblBacteria" id="AEB47465">
        <property type="protein sequence ID" value="AEB47465"/>
        <property type="gene ID" value="VAB18032_01905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01905"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_60_4_11"/>
    <dbReference type="OMA" id="TVCVWTL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="435" mass="45616" checksum="9958AB2ABB6A6FC0" modified="2011-06-28" version="1">MHAIRGWFRDTTGGLPRTFWYLWTGTLINRLGSFVLVFLAIYLTQERGFSATQAGIVLGLWGAGGAVGTTVGGTLTDRWGRRPTLLVAHLGGAVMMLALGFAHELWAVGLGALLLGLFAEAARPAFGAMMIDVVPERDRLRAFSLNYWAVNLGFACAAVLAGFAAQAGYLLLFAVNASTTLVTAVIIFVKVKETRTITVSTRVGAAGVGALRTILNDRVYLGFVALNLLGALVFLQHISMLPIAMADSGLSPATFGSVIALNGVLIVIGQLFVPRLIRGRSRSHVLALAAVVMGVGFGLTAFADVAWFYGLTVLIWTLGEMLNSPSNATLIAELSPSELRGRYQGVFSLSWQLAGAAAPILGGLVREQAGNATLWLGCAVIGLVMAVGHLLSGPARERRALALRTTGAPPVVTPRSTAPQPAAPKTAEPVATTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FER8</accession>
    <name>F4FER8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDP-glycerol:poly(Glycerophosphate) glycerophosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_06690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731135.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06690"/>
    <dbReference type="EnsemblBacteria" id="AEB42462">
        <property type="protein sequence ID" value="AEB42462"/>
        <property type="gene ID" value="VAB18032_06690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06690"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003394_0_0_11"/>
    <dbReference type="OMA" id="DRWDYSI"/>
    <dbReference type="OrthoDB" id="1408977at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="6">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="729" mass="82687" checksum="521A3174CB5664D0" modified="2011-06-28" version="1">MTLISFVVPAYRVQGYLRECLDSILAQPVTDIEVIGVDDCSPDASGDILDEYAARDGRVRAVRLDRNLGLGPARNAGLDRAVGEYVWFVDGDDWLVPDCLVEVAERLHTTRPDVLLVDHVRAHWDDTVTGSAMAEVFPEPTGPVTFRLRDRPETLELLHTAWNRLVRRQFLAEVGLRFAPGWYEDVSFSYPVLLAADRVGVLDTVCVNYRQRRAGAITKTQGERHFEVFEQWHRVFREADRFDAGQLRAALFERMMWHYLTVLGNEDRIPAELRPTFFARVTIDHARFRPPGGHRIPAGVEGLKHRLVAAGQWRTYSALRATSRTGEKARRAAGRVRRRVVPPAKATVRAARDVALYGYHRAELRRPLDENLAVYAAYWYRGYACNPAAIYEAARQAAPEIRGVWIVRRDRVHTLPEGIEYVVAGTPAYHRVLARAKWLINNVNFPDSVRKRPGSVHVQTHHGTPVKVMGLDQQRYPLGAEGMDFTGLLRRVDRWDYSITANSFSTQMWERAYPAAYTTLEVGYPRNDRLVTATTQEVLRLRAELGAGLGEQVVLYAPTHREHLPGYRPPFDPERVLDAIGPSGLLLMRSHYFHDRDRRAWPPAGRDRIIDVSAHPQVEELYLAADVLVTDYSSAMFDYAVLDRPIVIYAPDWDAYRLTRGVYFDLLAEPPGPVARTFPELLDVLRAGLSDSVAADHTRARFRERFCALEDGQAAQRVVRRVFLGDISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FET7</accession>
    <name>F4FET7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731154.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06785"/>
    <dbReference type="EnsemblBacteria" id="AEB42481">
        <property type="protein sequence ID" value="AEB42481"/>
        <property type="gene ID" value="VAB18032_06785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06785"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070586_1_0_11"/>
    <dbReference type="OMA" id="THGCLAY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="190"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="29830" checksum="9C5CA96F69E2BF14" modified="2011-06-28" version="1">MSGQALPYGHLCWAYDDPAGFTTRAEDFLRSGLAAGEQVWYVVAGSPGPVRDRWRDLDLFADALSSGAAEVLTLDAAYSGGQVIDPAGQVSAYQMAIRAALAAGYSGLRVAAACTELVRTPAQRAMFARYEQQINRMMRGEAFRAMCGYHRPTLGDRAVAELACLHPEHNVTDLLFRLYAPTAHPGHAVLVGELDPASHDLFRAALEHSELRPVDDELILDASGLRFLDHRTLVHLSEYAQQREARLVLRGCSAGTVRLAALLDLPGLSMEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEX5</accession>
    <name>F4FEX5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12865"/>
    <dbReference type="EnsemblBacteria" id="AEB43687">
        <property type="protein sequence ID" value="AEB43687"/>
        <property type="gene ID" value="VAB18032_12865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12865"/>
    <dbReference type="HOGENOM" id="CLU_3190363_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="46" mass="5184" checksum="5CFD7ED781D1AAE9" modified="2011-06-28" version="1">MHSTDGGVGLTWRQPGQPAYEPELPLRRKGLDDPESITLRYYPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF82</accession>
    <name>F4FF82_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733642.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19425"/>
    <dbReference type="EnsemblBacteria" id="AEB44987">
        <property type="protein sequence ID" value="AEB44987"/>
        <property type="gene ID" value="VAB18032_19425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19425"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_1_11"/>
    <dbReference type="OMA" id="VDFMANT"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312986" evidence="1">
        <location>
            <begin position="31"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="453" mass="48490" checksum="CAA74BD251D7EBBD" modified="2011-06-28" version="1">MPEFSTRFTRRRLALLVPLLTAGLTITACSAPGTEQTPSGDADAAVSTELGTDPITLEMYAETGFPLAKALADEFTKQHPNVTFNVREDQFTVIVENAPRVLASDNAPDIIRLPTMVDLVKDGLLKNLDPYFDAHGWDKFPASQLVQLRLTDGGAQRGSGSLYGMGLGYSVTGVFYNKKQAEQIGMTQPPATIAEFEDLLAKAKAANLQPIMQFNKNTAGINFPHQALQNQFGDPQQIADWIFQKPGATFDTPAALKATESIQKWAQAGYFPKDANAIDYTAMMGEFMKGNGVFMFNGDWESANLDKNMAGNVGFFLFPGETPDAKRVAMSAPNTFGVGAKAKNADAAAYFLNWAHTNDKAREISVNVGGSHPGGPSTSALPAVGEGTVLAETLKASQQLGADNGAVDFTANATGGIFASAITPEMQKLIAGQQNPQGYVKAVQAEYEKELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFA8</accession>
    <name>F4FFA8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19555"/>
    <dbReference type="EnsemblBacteria" id="AEB45013">
        <property type="protein sequence ID" value="AEB45013"/>
        <property type="gene ID" value="VAB18032_19555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19555"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OMA" id="GFGFCPE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="242"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="494" mass="54016" checksum="D7657E57EC9AC602" modified="2011-06-28" version="1">MRALHNVDFRLFPGEVHALMGENGAGKSTLIKVLTGVYGIDEGTITLGDEQVAFSGPMQASAAGVSTVYQEVNLCPNLSVAENIFIGREPRLFGAVRWGEVRRRARKLLTRLDLDIDVTAPVASYSLAVQQMVAIARAIDVQARVLILDEPTSSLDAGEVAQLFRVMRQLRDEGIAILFVTHFLDQVYGIADRITVLRNGTLVGEYPIAELPQLALVEKMIGKELDVLERLEEQPRRELAALEGGTPFVAVSELGRKGAIAPFSLTIHAGEVVGLAGLLGSGRTEAARLFFGADRADRGEVAVNGKPTSLRNPVQAIEYGIGFCSENRRAEGIIPDLSVRENMILAMQAARGWLRPIPRRRQDELVEQYIKALSIRPANPDVPVRNLSGGNQQKVLLARWLITEPRLLILDEPTRGIDIGAKAEIQKLVVQLSDGGMAVLFISAELEEVLRLSHKVAVMRDREMVAQLDNDDTVDAERVMQTIASGSTRKEASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFG6</accession>
    <name>F4FFG6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25850"/>
    <dbReference type="EnsemblBacteria" id="AEB46268">
        <property type="protein sequence ID" value="AEB46268"/>
        <property type="gene ID" value="VAB18032_25850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25850"/>
    <dbReference type="eggNOG" id="ENOG50335T8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121887_0_0_11"/>
    <dbReference type="OMA" id="YAMANPL"/>
    <dbReference type="OrthoDB" id="1822122at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="171" mass="17955" checksum="A5B9A0F688226AAF" modified="2011-06-28" version="1">MSAPPVDGTDPTGHRPATPDSRRPPSGSLAARQAELVAALVAGGPPPPGFAPAPLVAARAALLRKRAGEVARHWPLLAAGLAPHWPATFTEWAADRPTLGGLRDGWDLARALHARHALPALGAEELAVREAAYRYDGDAAPRRRRWPAVGRAGAAVAVQLAGRVRLLRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFN6</accession>
    <name>F4FFN6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736147.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02145"/>
    <dbReference type="EnsemblBacteria" id="AEB47513">
        <property type="protein sequence ID" value="AEB47513"/>
        <property type="gene ID" value="VAB18032_02145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02145"/>
    <dbReference type="eggNOG" id="ENOG50339V2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_840995_0_0_11"/>
    <dbReference type="OMA" id="FWLARHM"/>
    <dbReference type="OrthoDB" id="1808481at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="344" mass="35256" checksum="A1C0B02D02A3546B" modified="2011-06-28" version="1">MFPSSSPETGREPWADDPPPAGGAAPSTGPTVENDEARRSGGPRRLRRGGSARRSDEALDGDDEEETEPPVEVSRQLSLAIAGFAALLGLGLVLGAHTSGPDHRLPFTFVVLTVQMLFLLGWTMVTRPPALPVVLGVGALSALAADAVAVRSSEARLGPLLYIAIGAVLATVLGQLVRRVDRVRVTDSLRTTATIMFGTVAFATLIVLSRIPAGTQAIVVCLTAGAVTVAVARATDAFAAWPRLAPQVPRGAAGVVGGAMVGTLVGAVLGSYLVTPFTPTRAAILGLVAAGVAVLADLAVSYAEAGRLMAGEQPTVWAARHVQGPLGALAMVAPAAYLMCRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFZ8</accession>
    <name>F4FFZ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07270"/>
    <dbReference type="EnsemblBacteria" id="AEB42578">
        <property type="protein sequence ID" value="AEB42578"/>
        <property type="gene ID" value="VAB18032_07270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07270"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="OMA" id="HRHEILV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="401" mass="41945" checksum="C51CC4AE3CD266D3" modified="2011-06-28" version="1">MEVDVEARAPRRANRSTVLAHVLTRGPVTRTAIGQETDLSPATVSRIVEQLLDEGLLVETDGTPTATRGRRATRVAIAAGRGVVCGVDVGGSNVRMVVADLAATPLVSRTVPTPAQYDAPRLAQWLADLIRQTVGDHLDRLDCVAVGLPGAVREHDRAVSNAPNLPQVEDPEFLRLLEKRLATGVEVDNDSNYALLGELRFGAARNAQTAVMFTIGAGLGAGVAIDRRLFRGRSGMVGEFGHLPAGPLGTSLEQIISGPGILARARDLGLPFDNPADVFRSTDSRLVPVKQYVEQALLIILTAAVVAYEPEVIVLGGGISHALKPDLGWLGGRLREIVPVTAAAVQSAELGDLSGALGAVVAALHTAYGRLGLAEPDLAHVPQPDALAGCDLHALSANAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGD8</accession>
    <name>F4FGD8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_19870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733731.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19870"/>
    <dbReference type="EnsemblBacteria" id="AEB45076">
        <property type="protein sequence ID" value="AEB45076"/>
        <property type="gene ID" value="VAB18032_19870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19870"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="OMA" id="ACVGKPY"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="25161" checksum="5FC7F1EB420AAA13" modified="2011-06-28" version="1">MTVGSNGRFVLLVIDDDESVGGALVAELADHRVRAHHYPHAAEALLDAGALQPDAAVVASGLTTMSSTEVVRLLARRAGIPTVVGVGDDDGGVAAAALKAGATAGVRRPYRAAEVLPILRAIRPETSGALDPPIEIGGLRVDPATFEVSHHGRVVALPMKEFRLLYFFMSNAERTVTREQLLAAGWGGISDDTSNTLTVHIKRLRRRLALDGDQAPMIVTVRGLGYRFVPTATTPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGI9</accession>
    <name>F4FGI9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">X-Pro dipeptidyl-peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734975.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26130"/>
    <dbReference type="EnsemblBacteria" id="AEB46324">
        <property type="protein sequence ID" value="AEB46324"/>
        <property type="gene ID" value="VAB18032_26130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26130"/>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_5_2_11"/>
    <dbReference type="OMA" id="GRSWNIC"/>
    <dbReference type="OrthoDB" id="327988at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="306"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="570" mass="62506" checksum="7E52F7F0C764A902" modified="2011-06-28" version="1">MLDRVASRLAVAALRLPRARTRRITVRRDIALRVRDGVILRTDHYAPDLPDAPTMLIRTPYGRGGPMRLLCRLAAEQGFHVVIQSCRGTDGSGGTFDPFVHEREDGLDTLDWLRRQRWWCGAFGMFGASYQGFVQWALAADAGEELRAMVAVATASTTRDSTYAGESFALDTVLTWVELLQAQTVPWLARQWELKRGQPRLAAALSHLPLVEADRVATGVTVPFFQEWLRHHTPQADYWRSRVFDDRLHLVRAPVAMVSGWHDIFLPAQLRDYAALRALGARPRLIIGPWTHGSPGLFVAALREGLDWLGTHLTTAGTGRAAVPAAGADRSAAGEPADGPVRIHVGGVGGGWRDLPDWPPPAQATRWYLHPQSALRTAAPVPSPPDGFWYDPADPTPSLGGPLLVAQRSGPVDNRPVEARPDVLTWTSESLTGPLEVIGPVQADIHVRSDLEHFDVFVRLCDVDRRGRSWNICDGLVRIDPRRFPVDGSGAVAVTVPMWPVAHRFAAGHRLRLQLSGGAHPRYVRNPGTGEPLGTAITLRGGFREILHDPERPSAVVLPVVHSGSQLVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGY3</accession>
    <name>F4FGY3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731270.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07375"/>
    <dbReference type="EnsemblBacteria" id="AEB42597">
        <property type="protein sequence ID" value="AEB42597"/>
        <property type="gene ID" value="VAB18032_07375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07375"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062440_2_0_11"/>
    <dbReference type="OMA" id="PMISAWG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="28455" checksum="915B33D29CF96FED" modified="2011-06-28" version="1">MTTTAYQFRNAPAQLGPLQQVLDPITRHDLAKIPIRPGWQALDVGAGAGSITRHLADTVGPTGGVIAVDLDTGLLDPTSVIDVHRRDLRDGLDLPITPDSLDLIHARCVLEHLANRTDLLRQMIALLRPGGWLAVGEIVYSPTVIHRAPAADDRDLIHRVIHAILDILSDGGTDLDWGNHIHAHLLDAGMTHVHSHTRADTWTGGGPGCLLLADNAHQLHDRLLPVADLDEADLTRFGELMTDPTVSLRGYQFTSSLARKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHC0</accession>
    <name>F4FHC0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732565.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13930"/>
    <dbReference type="EnsemblBacteria" id="AEB43898">
        <property type="protein sequence ID" value="AEB43898"/>
        <property type="gene ID" value="VAB18032_13930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13930"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_5_1_11"/>
    <dbReference type="OMA" id="HMRGRAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="8902" checksum="DBCAB69108AD14E6" modified="2011-06-28" version="1">MKLNSKGQVTIPAELRVRYNLHEGDEVDVIEEGGALRIVRVEDAETRGRRLVRHMRGRGGAREVEGMSTDDLMDLLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHG6</accession>
    <name>F4FHG6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20190"/>
    <dbReference type="EnsemblBacteria" id="AEB45138">
        <property type="protein sequence ID" value="AEB45138"/>
        <property type="gene ID" value="VAB18032_20190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20190"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3013044_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="56" mass="6029" checksum="03BF03AD5879BA90" modified="2011-06-28" version="1">MQVETLADNVAMIRAATQAGFVREGTLRRAAWAHGDFADQVVLGLLGTEWDANARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI04</accession>
    <name>F4FI04_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03065"/>
    <dbReference type="EnsemblBacteria" id="AEB47697">
        <property type="protein sequence ID" value="AEB47697"/>
        <property type="gene ID" value="VAB18032_03065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03065"/>
    <dbReference type="eggNOG" id="ENOG502Z8IE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023241_0_0_11"/>
    <dbReference type="OMA" id="GPMFRVF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="668" mass="74543" checksum="266E26E50A202829" modified="2011-06-28" version="1">MPTPLDELRNEAVRWCAAEAGRFEGLVSSSADPLTTDSLVRRAALAAAPLALRSGAWLQWQSAPGNADDETVLRILTLYASDVGVGRPQDSRGSVYLSLLRQLHLSEHAAPVARMVHDPRVADHHFHLAATLLAMSRRPEDFRPELVGADLCLRTVGLLPALRLVRQVHPQLVDWTAIDPSAARADDERSGLQLCLAIVEHGFDDGELARVRTGFRWAFTVLKRWSASLFAELDNARDPAYEMAELLRHRAREGAVYHQVFAIAGRSLSDWLHDARTDPSELLTELAKSRLVKPGRSADSPLVNGLVSERGPMFRVFSPADLLVIRRWIDSLPSRQPEPEPPKAATEADAVSAKLLATVMAGPVDEGREPGDIREAYHLLQQRTDTPAIRRFALDYVRGWLARSRHRMASDPQRLPEVWGREGLRPWLVEQHDRQGRDFEASATTPMPTREELIDSTVQLAPLTLIDGAWLQGFTDYEHAASEQGYFLFETYWDELGNGVPRLNHPLIYRQVLAEMDIKVPPTASREFAMWDGFRDESFELPVYWLSIGRFPRTFMPEILGLNLAMELSGVGGTYRRARQALKKYGFSTKFVDIHNTIDNVATGHSAWAADAVDTYLASLPVSHGAGAVAEVWERVRTGFRSLNPPSGLLARRAFRRARKASRSLAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI10</accession>
    <name>F4FI10_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736335.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03095"/>
    <dbReference type="EnsemblBacteria" id="AEB47703">
        <property type="protein sequence ID" value="AEB47703"/>
        <property type="gene ID" value="VAB18032_03095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03095"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071562_0_0_11"/>
    <dbReference type="OMA" id="YDEFMYL"/>
    <dbReference type="OrthoDB" id="1421764at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="344" mass="38615" checksum="8E5DEEE883B03959" modified="2011-06-28" version="1">MKLQREILTPQMLQYDDFSSRGETEYVPYLMYFNRPNYRSDAINTDRLGFRISHSATEQASVGSSVPEGPVRLLVGGSVPLGYGSTSDAATMASRLWTEHAPSRPWLTYAGHCYNSTQELLLFLLYRHLLPPVEEIVIFSGFNTLVMSRLVEMHRADQGPFYFCGEFFEQMEEVKSRHRKSSRGFGRRNKPTVPAWPSPDEVRPELDDAIASAVDLVGRHLDSWQVLAAATGARVSFVLQPLATWLREETAPQEKLIFDELDRISKLGTWEALYGDVASVEAGQRYADALAPACEKRGVRFVNLNPVLRAAVTDQTWLYVDRAHLTDEGNDIVAALLAEQLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI67</accession>
    <name>F4FI67_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conjugative transfer gene complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_30339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AB-18-032</strain>
            <plasmid evidence="4 5">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713153.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30339"/>
    <dbReference type="EnsemblBacteria" id="AEB48031">
        <property type="protein sequence ID" value="AEB48031"/>
        <property type="gene ID" value="VAB18032_30339"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30339"/>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029028_2_0_11"/>
    <dbReference type="OMA" id="EVRMGYE"/>
    <dbReference type="OrthoDB" id="246216at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="3">
        <location>
            <begin position="416"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB48031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="593" mass="63189" checksum="744AC69FD8ECC292" modified="2011-06-28" version="1">MNRRPAGPRGGHDDAGLIAGGLAALVLVVAGTVWLPVVLTRPPGYTGGHPIQVALAVLRGDITWTTMCTLVAVAQLAVLLLLIGAAVAVRRWIGRRRTRVDSAARRMASRADLAHLGPKGVADSGRRLRPSLAAVDRPDPDQLGVLIGTTVAGGMPLRQSWEDMAVDIWGPRTGKTTSRAIPAIVAAPGPTLVTSVKGDIVDATREVRAARGSVWAFDPQHILGAEQSMWWNPLRAVATITDARRLAEHFAAAEREPGVSRDAFFDPSSEELVANLLLAAAVSGRDILAAYRWAVSPRDDEPALLLRDCGFDLPADAVSGVVNMPDKTRGGIYAGAQKMLMCLTEPAVTAWVTPPTRGGVLEFDPASFVVSTDVLYLLSQGGPGSPAPLVAALTDAVLRAGELRARASTGRRLDPPLLSILDEAANICRLRQLPSLYSYYGSHGLPIITILQSYPQGVDVWGREGMRKLWSAANVRTYGGGVADPDWLEELSKLIGEHDVTTRSTSSSGSGWGQRSVSHATRRQRILDVSDLHALPRGRMVVYASGAPPALARTAPWQDGPYAAAIRASIARWDPTGRTDWTLTPDAPPEPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1D3</accession>
    <name>F4F1D3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732636.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14285"/>
    <dbReference type="EnsemblBacteria" id="AEB43969">
        <property type="protein sequence ID" value="AEB43969"/>
        <property type="gene ID" value="VAB18032_14285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14285"/>
    <dbReference type="eggNOG" id="ENOG50329AT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184524_0_0_11"/>
    <dbReference type="OMA" id="RTGPDTM"/>
    <dbReference type="OrthoDB" id="2002197at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="85" mass="9284" checksum="BBE90F9485BC86B7" modified="2011-06-28" version="1">MTDDRTWRKEERLSLEELDRAVARNTLDGQADDVTANDAGEEAAFGHGPEPADRGRVVPGSDLEPTDPERGYRPSTTGRTGPDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1M9</accession>
    <name>F4F1M9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Group 1 truncated hemoglobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="4">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the truncated hemoglobin family. Group I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733912.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20790"/>
    <dbReference type="EnsemblBacteria" id="AEB45258">
        <property type="protein sequence ID" value="AEB45258"/>
        <property type="gene ID" value="VAB18032_20790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20790"/>
    <dbReference type="eggNOG" id="COG2346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103526_2_1_11"/>
    <dbReference type="OMA" id="HQTQFIS"/>
    <dbReference type="OrthoDB" id="1697277at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016339">
        <property type="entry name" value="Hemoglobin_trunc_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002030">
        <property type="entry name" value="Globin_Protozoa/Cyanobacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002030-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="14074" checksum="06CD39270A34C7FF" modified="2011-06-28" version="1">MTVTEEPTPVSHFERIGGAGSVKAAVELFYDRVLADPELAGYFTAVDMAGQRRHMAQMLTVVLGGPNEYRGRDLATAHQPLQVPVAHYQQVGGHLTAVLTQLNVPGDVITDVQAVLAQVQDQVVAGGRQADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Q8</accession>
    <name>F4F1Q8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase-related fmn-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27051"/>
    <dbReference type="EnsemblBacteria" id="AEB46483">
        <property type="protein sequence ID" value="AEB46483"/>
        <property type="gene ID" value="VAB18032_27051"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27051"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091428_1_1_11"/>
    <dbReference type="OMA" id="NVNVAYV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrid_ox_like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="18751" checksum="58C999144EA218FE" modified="2011-06-28" version="1">MTDEAMAVGAARERITELIRAAGSCTLTTISLDGRLVGRPMLLQRAAFDGELWFFGYARSATVRQLRVNPEVEVSFADPEDQVLVSLSGTARDDHDPTRAAQLWRPELATWFPDGPATPGLMLIAVHVTAARCWERTGRRQDLLGGAGSAPPGASVFAPGGASVAAGAPRDHATER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1R0</accession>
    <name>F4F1R0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/FNR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_27061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735136.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27061"/>
    <dbReference type="EnsemblBacteria" id="AEB46485">
        <property type="protein sequence ID" value="AEB46485"/>
        <property type="gene ID" value="VAB18032_27061"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27061"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_4_11"/>
    <dbReference type="OMA" id="WVKIRTY"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="230" mass="24963" checksum="2B862A32917E4DDB" modified="2011-06-28" version="1">MEMRLPEPGDALTGVEMFAGLEPEVRQRVIAAAVPRTYRKGQLLFVENDPGESLIVLRRGAVAVFRTAPTGERAVLSVIRPPDVLGEVSLLDASTRSASAEAIEDCTALALSRGAFMELVHSNPRILDAVMRSLGALIRRLTEQNADHVFLDLPGRVAKTLVRLAGESQAPMITIELNQSQLAEMAGGSRQSVNQAIGSFANRGWLRTEGRRIVVTDVPALRRRAGMSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Y0</accession>
    <name>F4F1Y0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_03215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736359.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03215"/>
    <dbReference type="EnsemblBacteria" id="AEB47727">
        <property type="protein sequence ID" value="AEB47727"/>
        <property type="gene ID" value="VAB18032_03215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03215"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_2_11"/>
    <dbReference type="OMA" id="IGFNYIF"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="112"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="322" mass="34009" checksum="5DEF9974D13E7407" modified="2011-06-28" version="1">MTIISGKKREKIDRLAELAAREDERGVSLWQDAFRRLRRNPAAIVGAVILAIFVLVAIFGPFFVPYGPKDTMGIREGVVKVGQGLIPGPSSEHWLGYDHQGRDVFSRMIIGARQTLLVGVVATLIGLALGALIGGVAGAAAGLGGRWGRMVDAVLMRFIDMLLALPSLLLAVSIAALLGPSLITVMIAVGMVSVPIFARLLRGSMIVQSNKEYVLASTSLGVSKSRIALAHVLPNSLAPVIVQATLTLATAIIEAAALSYLGLGNPDSSVPEWGVMLADAQPWLGIRPALAIYPAVAIIITALGFTLLGEAMREALDPKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F273</accession>
    <name>F4F273_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731433.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08220"/>
    <dbReference type="EnsemblBacteria" id="AEB42762">
        <property type="protein sequence ID" value="AEB42762"/>
        <property type="gene ID" value="VAB18032_08220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08220"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067347_1_0_11"/>
    <dbReference type="OMA" id="CTWGGAT"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="286" mass="30209" checksum="D63142A6DF214AF8" modified="2011-06-28" version="1">MLPRIDLHTHSTASDGTLSPPQLVRAAAEAGLDVVAITDHDTTAGWEPALQALPGGLRLVRGAELSCRWNGVEPSLPLHLLAYLFDPDAPELVAELARVRAARLQRGERIVALLWADGIDVSWPEILAGAGGGTVGRPHIAQALIRAGLVVTTTEAFGPDWLGERYRLPKEDIDVFQAVRLIRAAGGVPVFAHPRATRRGRIVPDELIAELAAAGLAGLEADHEDHSPAERAHVRGLAADLGLLVTGASDFHGTHKTVQLGAFTTAPEAYERIVAESSGVVEVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F284</accession>
    <name>F4F284_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_08275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731444.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08275"/>
    <dbReference type="EnsemblBacteria" id="AEB42773">
        <property type="protein sequence ID" value="AEB42773"/>
        <property type="gene ID" value="VAB18032_08275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08275"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_1_0_11"/>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="OrthoDB" id="1402673at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="317" mass="34134" checksum="B0042C4D6BD8E4B5" modified="2011-06-28" version="1">MSEHSANPSAAAATGRPRAVKAVIPAAGLATRFLPATKAVPKELLPVVDRPVLQYIVEEAAQAGIGDILLITGRGKTSMVDHFDRRPDLEERLAEKPDLLAAVKRTEELAAIYTCRQPEQLGLGHAVGYAESHVGDEPFAVLLGDEFVKPSEPLLPAMLELQARTGGVVLAFFEVDPAETKRYGIASVEPAEAELTDIGEVVKVTGMVEKPTPEEAPSNLAVLGRYVLPGKIFDAIRRTRPGSGGEIQLTDAMELLRTEGTPVHAIVYRGTRYDTGMPLGYLQTVVQIAAEREDLGSEFRKWLAEFVNSDASGGRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2B1</accession>
    <name>F4F2B1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731471.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08410"/>
    <dbReference type="EnsemblBacteria" id="AEB42800">
        <property type="protein sequence ID" value="AEB42800"/>
        <property type="gene ID" value="VAB18032_08410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08410"/>
    <dbReference type="eggNOG" id="ENOG5030IEV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813320_0_0_11"/>
    <dbReference type="OMA" id="YQQPADY"/>
    <dbReference type="OrthoDB" id="1862442at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="32188" checksum="3650B298594DBA4E" modified="2011-06-28" version="1">MSGTPHPTSGAPQPTSGTPHPASGAPQPTSGTPYPPAGPLPPSGPFPPGPGYPAGPYAPGGAYPPADPKQAGGGYPPPGGYPPPGGYPPPGGYPPGGAYPAGGYPPGSAAPMPTSGGSGSRTTLIVVITVVVLALLCCAGGVVALIAGMNRTADEIAEAIPTPPVTAPRTPDAPPPDGGIPPVFSEEEGETFNMRPGDTLVASDNSGTIEITVTRFRTVTESCRSFAPAPQKGRFLIAEVNARVTKGTASINPFYFQWRAADGSTVNGLVGAIYGCGDPLNAGNGLPAGTTRSGRVVFDVTDTNGVLEYLHQFEIAGSWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2G3</accession>
    <name>F4F2G3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_14615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14615"/>
    <dbReference type="EnsemblBacteria" id="AEB44035">
        <property type="protein sequence ID" value="AEB44035"/>
        <property type="gene ID" value="VAB18032_14615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14615"/>
    <dbReference type="eggNOG" id="COG4152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="TFCARMY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="32527" checksum="DAE26BF3B361F561" modified="2011-06-28" version="1">MDAVTTVLRLDGVDRSFGDRQVLKNVSFEVAAGRMTGFVGGNGAGKTTTMRIILGVLAADAGRVTWGGRPLDRQIRGRFGYMPEERGLYPKMSVREQVVYLGRLHGMTAEGARRATDTLLERIGLDERGDDLLETLSLGNQQRAQIAAALVHDPAVLVLDEPFSGLDPMAVDTILTVLRERAAAGVPVLFSSHQLDVVERLCDDLVIIADGTIRAAGSRELLRSSATTRRFELVVDTDAGWLRDQAGVSLVDLDGPRAVFDLAADTDEQPVLHAALARGPVRTFRPVTPSLAEIFREVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2R6</accession>
    <name>F4F2R6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733985.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21155"/>
    <dbReference type="EnsemblBacteria" id="AEB45331">
        <property type="protein sequence ID" value="AEB45331"/>
        <property type="gene ID" value="VAB18032_21155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21155"/>
    <dbReference type="eggNOG" id="COG1944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020532_0_0_11"/>
    <dbReference type="OMA" id="GVLFHNA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="408"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="717" mass="76087" checksum="785A44ECC2DC10A9" modified="2011-06-28" version="1">MSESPDAGKTLAMRPKLRHDVVFLDAPAGAYLRGPDTAFLIKGRTAFRWLTSLSPYLTGEHTLAQLTATLDDGQRGTVLTLVRALIARGFAKDAGERTELPQPLARRFAAQVEFVDHFADDPTGRFLRFHQARVALGGSGAPLLAAARGLLRNGCVTLDLYPEDDPGWYVEALRADLDELSADQIAAEVNVHAAALTVAGADAVVYCTGPEGLSRLADLARTCHRDGPLLVPVHWDEQRTVIGPTVATGQTPCWLCAQLRLTAAADPATSARFWRQLAVSVGAPAVLPEVTGRMVGNAAAFELFRVLTGALPADTATGVLLLDTTTLESTRERVLPHPACPVCRHVEVPTPPAPADSDDETTYQRAEVLVAPNAGVFTRFVDDPLEQAPLKTARLRLPGRSGPREVTAFDVHTVMGARLAAYRTAIRDHAGRYADPSGTLITSAAELRERGADPVSWTELDTAAGAPPDDPRRRWLPARVLGGADEVWVPAALALPTGGHDTEGWAEPTVAGAAVGATLDEVIDRGLADALAYHALISAMRGRSGPRLVGDEELIGDDDTAFVVKAAHRLGCRLTVVALPAAAPAHAVLAVTELPGTDRRYWALAGGFDPVTTRLAAVRDAVGHVQVRHFERTDADLGDPVLRDFEPATLLADLAPVGSTTDPADIPAETDRAAVLAALAQRSISALLVETTTRDIHAGGAFRSGVVLLRHHGRTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2R8</accession>
    <name>F4F2R8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_21165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733987.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21165"/>
    <dbReference type="EnsemblBacteria" id="AEB45333">
        <property type="protein sequence ID" value="AEB45333"/>
        <property type="gene ID" value="VAB18032_21165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21165"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088490_0_0_11"/>
    <dbReference type="OMA" id="GWGTWKT"/>
    <dbReference type="OrthoDB" id="1286457at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="28834" checksum="0564B9605070A4FB" modified="2011-06-28" version="1">MIASVRAAWFADRRRPAVWTVTATWTLLALAFGIGIPYLVHLTLAGDPEQADAAETLLAAVLPGQLVTTGIGLFPLFGGAIVVILGALVVGNEYRWGTLNLIFTQRPRRGQVLAGHAVVLCGLTLLVAVLTFGALAVVTGVLAVVEGRGADWPPVADLAGAVAAAWLICTAHASVGWFLAIVFRSTATAIAIGLVWTLVLENAISGLALVLSPLEVLQKLLLAPSSGALAGALGARSQFDGGTPGVLESSSAVLPATVLLGYTLLMFGLGSWLAARRDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2U1</accession>
    <name>F4F2U1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_27396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735202.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27396"/>
    <dbReference type="EnsemblBacteria" id="AEB46552">
        <property type="protein sequence ID" value="AEB46552"/>
        <property type="gene ID" value="VAB18032_27396"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27396"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_1_11"/>
    <dbReference type="OMA" id="MKVPSPG"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014276">
        <property type="entry name" value="2-oxoglutarate_DH_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02927">
        <property type="entry name" value="SucB_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="610" mass="63363" checksum="02E8017C397B233B" modified="2011-06-28" version="1">MPVSVTMPRLGESVTEGTVTRWLKQEGDTVEVDEPLLEVSTDKVDTEIPSPAAGVLTRIVVGEDETAEVGSELAVISGEGESAGGPSERQAPAEHQESPPAEQAAEAAAQPQAEAEQSAVQEPAEQPAPAAAPSGEGTPVQMPALGESVTEGTVTRWLKQVGETVEVDEPLLEVSTDKVDTEIPSPVAGTVLEIKVPEDETAEVGATLAVIGAAGAAPAEAKPEPKPQAEAKPEPEPEAKPQAEAKPEPQVSEPTPGTSYNEPAAEAETSPEPTKTEQAAVPPAPTAQPAAAPSANGEAAGYVTPLVRKLASEHGVDLASVNGTGVGGRIRKQDVLDAAEKARAAKAAPAPAAAQPAAQAQPAAKPQPSAKRGTTEKLPRIRAAIAKRMHQSLQETAQLTTVVEVDVTKVAKLRARAKDSFLQRHGVKLSFLPFFALAAIEALQTYPIVQARMDLDAGTITYPDAENLGIAVDTERGLLVPVIHNAGDLNLGGIAKRVADLAERTRTNKISPDEIAGATFTLTNTGSRGALFDTPIVPSPQSAMLGTGAVVKRPVVVNDPELGEVIAVRSMVYLAMSYDHRIIDGADAARFLTAVKERLEAGNFEAELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2V2</accession>
    <name>F4F2V2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735213.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27451"/>
    <dbReference type="EnsemblBacteria" id="AEB46563">
        <property type="protein sequence ID" value="AEB46563"/>
        <property type="gene ID" value="VAB18032_27451"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27451"/>
    <dbReference type="eggNOG" id="ENOG5031K3Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089257_0_0_11"/>
    <dbReference type="OMA" id="GDLMSNM"/>
    <dbReference type="OrthoDB" id="1522794at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="25475" checksum="4656EDA213C0840F" modified="2011-06-28" version="1">MAKPQEKVSFGQRLKQIGLVFRFTAKQDKWFAPLAAGAVLIPLALTVVAIVLWGWLWLPLGILFALLCLLIVLNLRSNRAMMNAAEGQPGAAAQIMESMRGDWRVSPAVSSTTQMDMVHLVIGRPGVILLAEGNPQRVRSLLSQEKRRLAKVIGNAPLYDYVIGQEEGELPIRKLRMTLMRLPRNLSGKDVNSLDKRLKALTARPQMPKGAVPKNLRPPRGAFRQMRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F369</accession>
    <name>F4F369_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736480.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03830"/>
    <dbReference type="EnsemblBacteria" id="AEB47848">
        <property type="protein sequence ID" value="AEB47848"/>
        <property type="gene ID" value="VAB18032_03830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03830"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020866_3_0_11"/>
    <dbReference type="OMA" id="GWREPVN"/>
    <dbReference type="OrthoDB" id="1439550at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025048">
        <property type="entry name" value="DUF3987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13148">
        <property type="entry name" value="DUF3987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="532" mass="56294" checksum="7CAFD51BFBECCE9C" modified="2011-06-28" version="1">MSAARLHLVTDHPHATGEPSAGGPLWDVPVPLTGPTTTPPPFPVDVFPRWLADMVTGVARFTATDPAMAGTLAVAVLSACAGGRLEVEPVAGWREPVNIFAAVIAGPGERKSPVHRAMTAPLFAAQSTLAEAIRPRIAEAAALRDIADRQAEQAKTAAAKASDPHKRDEAAAEAVAAAIAAEAITVPTLPKLIVDDATPEALIGLMAANGGRMAIISDEGGIFDTLAGRYSGAPNLDPYLKGHAGQPMSNERQTREGASVDKPALTVCVMAQPTVLRKFGGNADLAGRGLPARFLFALPRSLAGYRPVDTPPVPEQVTAGYRHRVHDLAATFAEWPDPDVVTLTDDAGRVRRAAAEQVEAELRPGGSLYDMREWGNKLSGATLRLAGLLHVAHHPNDAWLRPIDADRMADAVRLAEFFAAHYRAALTTIGTDSAVENARYVLGVLTGKHMATFTRRELHRRVSRRLPKSDDVSAVLAELVALGWVRTGPDGRYELHPRAVGDDGGSADTLTPAPDDNVSAAQDTREGVNGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Q4</accession>
    <name>F4F3Q4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734009.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21275"/>
    <dbReference type="EnsemblBacteria" id="AEB45355">
        <property type="protein sequence ID" value="AEB45355"/>
        <property type="gene ID" value="VAB18032_21275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21275"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261073_0_0_11"/>
    <dbReference type="OMA" id="YERTGAM"/>
    <dbReference type="OrthoDB" id="115556at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1306" mass="140618" checksum="868E0092B24AFDA8" modified="2011-06-28" version="1">MNGHEEIEEVPLDDWIAHLTVLVASPPDGEDLAELAGLLGQAYGERYVRDQDETSLLAAIVEFDRALTYAPHHEQAPFWHWGKGMSHLERTWLDDESTDDESTDHESAVGHLIEAYRGWPSEDTERDDVANTLLEAIWNRYLWRYAQSETPEATVEYGAEAMHALEVVLTSPTGEESTAYARMLLGVLLLNRYDNGSKDVPDLDQAIALLAESLARLSPDTTAHYFLACTELVAAYLEAAGLREDRTSVESAIQAADRAVEACPPGDAMRRHLLRHQAEAYAALWRLDADPANLTRAIDRWRAARAEDDDPLCQVALAELLYAAGDLDSLTEAVALWEQALPSVPRPRWVWVHLGATHLARWELAEVPGSLDAAARCLDHALTEGETPDELLSVHVMRVIVVRALLGHESARDPDRAPPGLHRVREILDEGGRALDDAPDSSPHDRALLAAVLLRCELSYVLQALVEPDSPRMHHLLAVGRMGGADQPADITLVLDLVEGILRQFDQVSRSDSTPDDGLPTFLRIVADERMTEADRTLLRSVLPNFLQARAARYFDDRPHRAAQAMAAALARGHSQTAAVIEAQMLAAVSEALGRGRLGDVEGMRTATRRAVALRRRLGPSRLNAAMLDPLVRLCEDLVDNIDGRGIRPQPPVPLPPGPPTHSATLSVLVGGVQVMAALRRADLPLLRQWADYLTDLAGRFPQHHVLRIGSLATAAKAQFPLAVLGQRQAAASAVAILEQATAEAGTNMAIWAELVHDLAYALRLAGDPDRARARRLGLDGLHGRARRVLLQAGTDYAMGTAREAAATATTVARWCLQDQADDDLVTALDAGRGLVLHAATASRNVAELLEEAGQAELATEWRQTGGLGRDQLTGAALASVLAAGEIPDDLRLRVLDALDLTTHGPLAQVRPGEISSALTALEADALVYLVPAAPPVPGLAVVVPSVGEVEILELCDLVAGDNAPVRRLLRAAFGADLAGAGRRAPRDAGPVGGPRPPSAGTAIDDLCRWAWRAAMSHLVAHLRPPDSAGPARVVLVPMGVLGLVPWHAAYRETTSGRRYAVHDLVVSYSPSARLLCTAAARPVQPIRSALVVGDPLGDLPFAGIEAQAIHRRFHPEGRYLGGPADDSGHLARPEAVLEWVRTVGAGSSLLHLACHGRVDPTRPADSHLVLADGLLPARDLLEVSRLAALDLGQVFLAACTTNLAGGLPDEAFSLATAFLAAGAQTVFGSLWSVPDVGTSLLMYQVHHFLYEQGCAPAEALHRAQLWMLDPDREPPEGMPAELATHCSRVDNAAPLAWAAFTHLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3W4</accession>
    <name>F4F3W4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734068.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21575"/>
    <dbReference type="EnsemblBacteria" id="AEB45415">
        <property type="protein sequence ID" value="AEB45415"/>
        <property type="gene ID" value="VAB18032_21575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21575"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083309_0_0_11"/>
    <dbReference type="OMA" id="ELFYPLD"/>
    <dbReference type="OrthoDB" id="705269at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="28535" checksum="3076FFFD4DC484AC" modified="2011-06-28" version="1">MTRGEPVGVLIRRWRERRGRSQLDLSSSTEVSTRHLSFVETGRATPSRAMIERLCDELDVPLRERNTLYLAAGFAPVHPESAYVDLGAARAAVAAVLAGHEPNPALAVNVRWELLAANNAMTVFLAGVPEFLRTPPVNVLRATLHPDGLSGRIRNLAQWRAHVLRRVRRQLDRTAAEGLADLLTELESYPAPTAAHADTGPGEDLVIPLRLSTEYGELALCYATTVFGAPRDVTLDEISIETFFPADAATAQLLRAMASATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Y9</accession>
    <name>F4F3Y9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735285.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27811"/>
    <dbReference type="EnsemblBacteria" id="AEB46635">
        <property type="protein sequence ID" value="AEB46635"/>
        <property type="gene ID" value="VAB18032_27811"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27811"/>
    <dbReference type="eggNOG" id="ENOG502ZWGX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114867_0_0_11"/>
    <dbReference type="OMA" id="ALCPHIE"/>
    <dbReference type="OrthoDB" id="1344131at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="17379" checksum="FDCA110693FE1F1F" modified="2011-06-28" version="1">MPTRGVVYVHSTPLAVCSHVEWAIARVLAAPVNLQWTAQPVDPSARRAECGWSGRAGTGAELAAALRQWPMIRFEVTEEPSPGADGERFMYVPGRGLFRATVGAAGDIQLGEDRLRSIMAAARGPEALAHALDKALGSAWDAELEPYRYAGDGAPVTLLTRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F413</accession>
    <name>F4F413_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_27931</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735309.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27931"/>
    <dbReference type="EnsemblBacteria" id="AEB46659">
        <property type="protein sequence ID" value="AEB46659"/>
        <property type="gene ID" value="VAB18032_27931"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27931"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037123_1_2_11"/>
    <dbReference type="OMA" id="LFAYRHS"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="315"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB46659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="379" mass="39721" checksum="B35492F53070E97F" modified="2011-06-28" version="1">MRASFGLGRIAGVPVGVNWSVLVIFALIWWGLSANLFPVSYPGRSVVAYVFAGLAAAVVFFLGLLAHEVSHAVVAKRNGLGVQGITLWLFGGVAELRGEARTPGAELRIAGVGPLVSLIIGAFFGVIAMVLGVAGVHGLLLGVMAWLAGINLLLALFNVLPAAPLDGGRLLRAAVWKATGDRTRASVVAARAGWVLGVVLIGLGLWRFLSGAGFGGLWLALIGWFLIGAASMEERQARMGSALRGIRVGEVMTPQPQTASGELTVADFVDNYLFAYRHTALPLTEDGRPVGLVTLDRVRGVPSEQRSSTTLEAVACRADDLVLASPDEQLTDLLPRLSECADGRALVVANGNLVGIVSPSDISRAVQRGHLRTQTTTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F475</accession>
    <name>F4F475_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LytR/CpsA family cell envelope-related function transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04030"/>
    <dbReference type="EnsemblBacteria" id="AEB47888">
        <property type="protein sequence ID" value="AEB47888"/>
        <property type="gene ID" value="VAB18032_04030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04030"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_0_2_11"/>
    <dbReference type="OMA" id="HIPASHD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="71"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="37469" checksum="E08FC66F0F2A4E2B" modified="2011-06-28" version="1">MAGAVLMMTSGVAIVGSKAVISQATGSITQRNLLGDAGKTLAEGGSDLKGPIDMLLLGVDARERWAADDVRADSIIVLHIPATHDQAYLISIPRDTEAQIPAWPKGNYAGGVDKINAAFQVGARNGGGWEGGAQVMAQTIKNMTGVSFDGAAIINFGGFKNVIDALGSVRICPKQDVKSTHMSYVDGKPMWNADAKKTGKPRTPVVHKKGCQEMEGWAALDFSRQRYGLANSDYDRQQNQQQLIKAMAKKASQNGTLTNPVKLNELIKAAGKAFILDTGGVSVEDFVFTMRGVTGNELIMLKTNGGTYNAKGNGNEALDEQTLDMFRAVRQDKLAEFVFYNPEVISNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4G4</accession>
    <name>F4F4G4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_09020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731593.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09020"/>
    <dbReference type="EnsemblBacteria" id="AEB42922">
        <property type="protein sequence ID" value="AEB42922"/>
        <property type="gene ID" value="VAB18032_09020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09020"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067823_2_0_11"/>
    <dbReference type="OMA" id="PSYHIGA"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="67"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="23595" checksum="6CD97D854F22CA44" modified="2011-06-28" version="1">MSLHPVNGDPHRFGTEAFYSSIGRAFVAMCAVVPVLFLIEGLDQWLGAGFDAAAGIIPQRIEGLDGVFFSPFLHHGFEHLYSNSIPLILLGTFVLAAGARRFLWSTLVIVLASGLGVWFTGSPNTIVVGASGVIFGYLGILLTRGIFERSWWNFAVFLLVGLLYGGQLALVLPTDERISWQGHLFGLLGGIVAAIIFRRRRPELDDPYGSTSPMTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4I7</accession>
    <name>F4F4I7_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Rok family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731616.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09135"/>
    <dbReference type="EnsemblBacteria" id="AEB42945">
        <property type="protein sequence ID" value="AEB42945"/>
        <property type="gene ID" value="VAB18032_09135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09135"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_11"/>
    <dbReference type="OMA" id="PMLEATF"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="299" mass="31047" checksum="FE47C72F0CE76209" modified="2011-06-28" version="1">MEQPANPRLLGIDFGGTKMAIGVGDVDGRLLVSERLPTNAEQGAQQALTRALDRARELADSTGGTIVAAGIASPGVVHDHSIELAPNVPGWEQLRLAEEVRAHLGVASVRVANDLNAAAYAELRLGALRGVDPGLVIGLGTGVAAAVTIGGEVIAGHHGAAGEIAYGLTDHSWPAGLEPMLEATFSGRALDELAQRLGLTGQAAALCAAAAQPGRFRDELRLRVDELARHLVTCCLLLDPHRIVLVGSVAGNEVVRELLIERLTHALPYRPEIVLSAFAQDAALLGSLAMAMEALPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4P2</accession>
    <name>F4F4P2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732849.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15360"/>
    <dbReference type="EnsemblBacteria" id="AEB44184">
        <property type="protein sequence ID" value="AEB44184"/>
        <property type="gene ID" value="VAB18032_15360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15360"/>
    <dbReference type="eggNOG" id="COG3937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109323_0_0_11"/>
    <dbReference type="OMA" id="GMANREN"/>
    <dbReference type="OrthoDB" id="1850732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="17777" checksum="1DBF40CC8DA65586" modified="2011-06-28" version="1">MQDAWRAYLELAMGLTEAPRKKAQDAVRRAMGSTGATAAQLQALADELRATGAANRESLTKLVRFEVERALGAVGLASADEVAELERRVRELERRLRTAGAAGGPATSGEASSVGTPATAAAAPPSKALAKQTVAKKAVAKKAVAKKTVAKKAVAKKATGGGSASARRADADGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F500</accession>
    <name>F4F500_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734142.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21945"/>
    <dbReference type="EnsemblBacteria" id="AEB45489">
        <property type="protein sequence ID" value="AEB45489"/>
        <property type="gene ID" value="VAB18032_21945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21945"/>
    <dbReference type="HOGENOM" id="CLU_127701_0_0_11"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="15197" checksum="B70320448FD9CEF6" modified="2011-06-28" version="1">MADCANGSFAARLRHLFDTRRKPGTGKPYTPDEVAKGTGLSTSYVNYLLNGERDNPTRSAIQQLANFFRVQPNYFFESVAPDVVSANVEVEADPDLETITVLARRMPAGPSRASLRAIVEQVAALEAQSKASGRRNQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F509</accession>
    <name>F4F509_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734151.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21990"/>
    <dbReference type="EnsemblBacteria" id="AEB45498">
        <property type="protein sequence ID" value="AEB45498"/>
        <property type="gene ID" value="VAB18032_21990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21990"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070540_0_0_11"/>
    <dbReference type="OMA" id="GYAHFTA"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="29350" checksum="28923D6DD56C1EF7" modified="2011-06-28" version="1">MAVSLTHLNGKPATAADLAPLAFAGYAHFTAMQVRDRAVRGLDLHLERLRRASEVLFGQHLSTSRVREYLRLAVDEGGPDASVACFVTSRPGEFMVDDTDPALDVLIKLTDPAQPPTGPMALDVVSHQRHLAGIKHVGEVAKTWYLRQARARGVDDAVFEDGTGRLSEATIWDLAFWDGETVIWPQADLLPGVTMQILTRQLAHLGVAQQTRDIRRADLTENLACVLMNSWTPAIAVSHLGDRQLADGTTFAHLLHEAYRNEPPTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5C6</accession>
    <name>F4F5C6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="8" type="ordered locus">VAB18032_04460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736605.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04460"/>
    <dbReference type="EnsemblBacteria" id="AEB47974">
        <property type="protein sequence ID" value="AEB47974"/>
        <property type="gene ID" value="VAB18032_04460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04460"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_4_1_11"/>
    <dbReference type="OMA" id="THHVVIR"/>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="137" mass="14584" checksum="77AB6AFA9E77B1A6" modified="2011-06-28" version="1">MLTAAQRLRRSSDFAAAVRSGRRAGRGTVVVHLTLPDTTGGTPDVAPEPVRGGTEENSAPVSRAGFVVSKAVGPAVVRNKVRRRLRHLVRERLSELPAGSTLVVRALPAAAEATYQRLGADLGDALRAARTSRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5F1</accession>
    <name>F4F5F1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ordered locus">VAB18032_09325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731654.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09325"/>
    <dbReference type="EnsemblBacteria" id="AEB42983">
        <property type="protein sequence ID" value="AEB42983"/>
        <property type="gene ID" value="VAB18032_09325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09325"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_3_11"/>
    <dbReference type="OMA" id="AGPFYYA"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="48"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="23983" checksum="3345E70AEC849688" modified="2011-06-28" version="1">MFLRRMKAEMISPDRALPGRPIAMPVADRHEVLGTPLKGPFPEGSQVAVFGMGCFWGAERLFWTLPGVFTTSAGYAGGYTPNPTYEEVCSGMTGHAEVVQVVYDSARISYEDLLKVFWENHDPTQGMRQGNDVGTQYRSTIYATTDDQLATAEASRDAFAPIVARAGKGEITTEIGRLGDYYLAEDYHQQYLAPTKNPNGYCNHGPNGMSCPVGVARTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5H1</accession>
    <name>F4F5H1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_09425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731674.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09425"/>
    <dbReference type="EnsemblBacteria" id="AEB43003">
        <property type="protein sequence ID" value="AEB43003"/>
        <property type="gene ID" value="VAB18032_09425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09425"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_0_11"/>
    <dbReference type="OMA" id="MDEMAFL"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="171" mass="18730" checksum="98774B74536FED1F" modified="2011-06-28" version="1">MTEHLSAMPGKPTSYSRVTLSRIMTAIDVNLYGTVHGGVLMKFVDDVAGAAAARHSGGTAVTAAIDEIVFSEAVRVGDLVHAYAQVNWTGQTSMEIGVRVMAERWDSAEQEPVRVATAYLVFVGVEVGGAPRPVRPVLPETAEDERRWREAEIRREHRLARRRAIQAHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5K6</accession>
    <name>F4F5K6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_09600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731709.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09600"/>
    <dbReference type="EnsemblBacteria" id="AEB43038">
        <property type="protein sequence ID" value="AEB43038"/>
        <property type="gene ID" value="VAB18032_09600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09600"/>
    <dbReference type="eggNOG" id="COG2173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060744_2_0_11"/>
    <dbReference type="OMA" id="YGDQLWA"/>
    <dbReference type="OrthoDB" id="880710at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="23115" checksum="01CE824431A3AD56" modified="2011-06-28" version="1">MILLCDPRVAAVPGVDDGDPLVDLRDVPELRLDGRAADPAGAYARLRQGVVERLLAAQRTLPDGLRLLVIEGYRPYEAQLNIFTAYRDELRRNHPDWSPQRVYEETTKFVSPVEVAPHSTGGAVDLTLCTADGIEVDMGTAVDATPEASGNACFTAATSIGAPARRHRRIMGAALACAGLVNYPTEWWHWSYGDRYWALMTGAPHTRYGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5N8</accession>
    <name>F4F5N8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44251">
        <property type="protein sequence ID" value="AEB44251"/>
        <property type="gene ID" value="VAB18032_15695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15695"/>
    <dbReference type="HOGENOM" id="CLU_3206673_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="45" mass="4703" checksum="F4AA27EF75852B89" modified="2011-06-28" version="1">MGALVAQMAKVIASALVKASMMPWGCGQTADCHELALTCRDGIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5R0</accession>
    <name>F4F5R0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15815"/>
    <dbReference type="EnsemblBacteria" id="AEB44273">
        <property type="protein sequence ID" value="AEB44273"/>
        <property type="gene ID" value="VAB18032_15815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15815"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597091_0_0_11"/>
    <dbReference type="OMA" id="FGYTERQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="458" mass="48877" checksum="D1611BDD2E4CA0FF" modified="2011-06-28" version="1">MLAVVVVRSGVIVAAQVDPEWWSSGRWNGRPIGEVLRRRDVTAVFRFLHARGVSYGRIAALVGVSPNRAAEIAKGVRQVTAYEVLERIAAGLNIPRLAMGLGRDEDADVSRAPGHRVAEGGADRSLASMAVNSLASLRLGMDEALASASVAPRQLELIEESASEHMRVYPSASPQVMLSLLAADCREVQVLSLRRQPAAVQARLSGVAAVLATMCADALMRLGEVTEARRWYGTAIHAADDSGQAQLRVLVRAQAAMLPYYFGDPTRAVALADAALAVTSIASSPGALAAAGRARALARIGAAEQARSGIDQARRLFDQAGDEDTNVAFRFPAKRLLFYLSGAYTWLGDTGEAYRVQDEALRLYGSAPAVPIDVALIALDRSMCLAQDRRATEAAVTARDAVADLPETQRTEIILNRATVVTAIPDKGQRGEAAMLTDYVRACRERARRLGTTAALGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F609</accession>
    <name>F4F609_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, CdaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_22340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22340"/>
    <dbReference type="EnsemblBacteria" id="AEB45568">
        <property type="protein sequence ID" value="AEB45568"/>
        <property type="gene ID" value="VAB18032_22340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22340"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017436_7_2_11"/>
    <dbReference type="OMA" id="VGYLWVQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="158"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="340"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="409" mass="44842" checksum="3053D99E381C254C" modified="2011-06-28" version="1">MRGELQRIVDAVAAHAGRPALIEDRRQRVVVYSEQNGLTDEVRRASILRRQSSPEVVAWVRDLGLADARGPVRTPARPDLGMLPRLCVPVRHHELLLGYVWFIDPDGTMTDVDLTATGLLKELSLALYRENLLGELAAQRETEAARTLLADSPETRDQAARALLEAGMIAADGPRTALVARLVAPAQRQPDELARIALEQALVAARRRAGIREALHLIRHDHGILLLPAEPVAGRPAPEIAARQLDEDLQHVTRALGSVERTVVGVGQTRARLADAAESYVEALHAARVGAQLPALGRVVFWSGLGSYRALARLGDQQLTVADVHPGLARLLATPGSQVLLTTLERYLDQAGNAHATAARLRLHRTTLYYRLQRIEELADTDLKDGDERLCLHLGLKLARLTGQHRPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F627</accession>
    <name>F4F627_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735428.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28541"/>
    <dbReference type="EnsemblBacteria" id="AEB46779">
        <property type="protein sequence ID" value="AEB46779"/>
        <property type="gene ID" value="VAB18032_28541"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28541"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_0_11"/>
    <dbReference type="OMA" id="MAWFFTG"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="233" mass="24978" checksum="41A5937364423DF6" modified="2011-06-28" version="1">MPLLYTIGKLTVAPTLRLAFRPTVEGLEHVPETGGAIFAGNHLSVADELFLGTVVPRHLAFWAKSEYFKGTTLKGRFSKFVLTGLGAIPVERAGGRAALSAFDAAIPALKGGDLVVVYPEGTRSPDGRLYRGRTGAVRLAIAAGVPIIPVGMIGTDKVQPIGARVPRPFTGKKITVKFGKPLDFTGRPDDRLSLRKMTDEMMAEIQKLTGQEYVPRYAPPRAQPKATGEPSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F662</accession>
    <name>F4F662_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735463.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28716"/>
    <dbReference type="EnsemblBacteria" id="AEB46814">
        <property type="protein sequence ID" value="AEB46814"/>
        <property type="gene ID" value="VAB18032_28716"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28716"/>
    <dbReference type="eggNOG" id="ENOG5033AEH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150001_0_0_11"/>
    <dbReference type="OMA" id="FTPVWFL"/>
    <dbReference type="OrthoDB" id="1936176at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="95" mass="9527" checksum="72167D338AA75CCC" modified="2011-06-28" version="1">MLVFVGIPAAVVLVIAGLVYAGSSRDGGGGAKRYRPGRPFNFTPVWFLGQPGELADSAGAVLAAGAQAPALTSRKQEQAGVETPAGGTGGASDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6J0</accession>
    <name>F4F6J0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07730</name>
        <name evidence="3" type="ordered locus">VAB18032_16060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07730"/>
    <dbReference type="EnsemblBacteria" id="AEB42666">
        <property type="protein sequence ID" value="AEB42666"/>
        <property type="gene ID" value="VAB18032_07730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44318">
        <property type="protein sequence ID" value="AEB44318"/>
        <property type="gene ID" value="VAB18032_16060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07730"/>
    <dbReference type="KEGG" id="vma:VAB18032_16060"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_11"/>
    <dbReference type="OMA" id="DRRTWTT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="117"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="32690" checksum="D7B89A2BC6126E71" modified="2011-06-28" version="1">MSELAADGIPVAVTCRVLNIARQPYYRWLARRVTDAELAQAYRADALFDAHRDDPEFGYRFLADEARDAGQPMVERTAWRICSGMGWWSAFSKRKRRGKGGKVGPPVHDDLVQRDFTADGPNRLWLADITEHRTGEGKLYLCAIKDVWSHRIVGYSIDSRMKSRLAVNALHNAVARRGDVAGCVLHTDRGSQFRSRKFVRALHQHHMIGSMGRVGAAGDNAAMESFFGLLQNNVLDRRTWTTRQQLRTAIVTWVERTYHRRRRQRSLSRLTPIEYETIMTPPASQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6S7</accession>
    <name>F4F6S7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734254.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22510"/>
    <dbReference type="EnsemblBacteria" id="AEB45602">
        <property type="protein sequence ID" value="AEB45602"/>
        <property type="gene ID" value="VAB18032_22510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22510"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_8_4_11"/>
    <dbReference type="OMA" id="KMIDRMV"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="149" mass="16341" checksum="6FF441CC74B08CFC" modified="2011-06-28" version="1">MSDHPGSAADLLPLLTRAERLLSRRVGGLLADEALSIEAWRVLCLLADGLGHPMSEVAAEASLPPGTLTKLVDQLVDRNLVFRRVDPIDRRRIRAYLTARGRREHERLSMLIQTNLAALSTVDDITLATHLTALITRLTPHPHPTPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6V2</accession>
    <name>F4F6V2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734279.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22635"/>
    <dbReference type="EnsemblBacteria" id="AEB45627">
        <property type="protein sequence ID" value="AEB45627"/>
        <property type="gene ID" value="VAB18032_22635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22635"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_1_0_11"/>
    <dbReference type="OMA" id="NIFWFLP"/>
    <dbReference type="OrthoDB" id="919913at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="389" mass="41681" checksum="167300669EFEDFBB" modified="2011-06-28" version="1">MLTFHWFLPTYGDSRDIVGGGHGVPVGRAGGSRPPTVAYLGQIARTAEQLGFVGALTPTGAWCEDAWLSTAMLTEVTERLKFLVAFRPGLLSPTLAAQMGATFQRLSGGRLLVNVVTGGEAHEQRAYGDFLDKDARYARTDEFLTVVRALWGGATVDHDGPYVRVERARLARLPDPVPPVYFGGSSAAAGPVAARHSDVYLTWGEPPAQVAAKLDWIRGLAAEAGRDVRFGIRLHVIARDTSEDAWAQARRLLDGIADADIRAAQEGLRRSESEGQRRMLDLHGGSRDGLEVSPNLWAGVGLVRGGAGTALVGSHTEVADRIAEYHALGIDEFVLSGQPHLEEAYWFGEGVLPVLGERGLWRHPARPAVSVPEPTGIPFATPPVPAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6V6</accession>
    <name>F4F6V6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_22655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734283.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22655"/>
    <dbReference type="EnsemblBacteria" id="AEB45631">
        <property type="protein sequence ID" value="AEB45631"/>
        <property type="gene ID" value="VAB18032_22655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22655"/>
    <dbReference type="eggNOG" id="COG2855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033541_6_0_11"/>
    <dbReference type="OMA" id="IIVKMIR"/>
    <dbReference type="OrthoDB" id="1856009at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="383" mass="39935" checksum="52086A0FF5384E5F" modified="2011-06-28" version="1">MATEATRGAAQTAPQAGLLAPPPRDRRFWAWTAAGLLVVVLLAALTRYLEQQVPEWAAGTALEDVAAAIEYPVYAIVLGLLGNLVVTLTGLHDRIAAAFRTEFFIKTGLVLLGASINLAVIASAAGPAIAQALLLISGVFLFTWWLAGRLGLDDKLRALLASAVSICGVSAAIAAAGAVRARREQLAYTASLVIVFALPSIFLLPWLADVLGLSPAVAGAWIGGNIDTTAAVTAAGALAGEDALQIASIVKVTQNALMGVVAVALTAYFALHVERRPGSARPGLGELWRRFPKFVLGFVAASVIATWYLKAVGADGKATIAIVNDLRTWFFILAFVSIGLEVRVAALRQAGWRPIAVFGAATVFNLVLALGLASLLFAGFTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6V8</accession>
    <name>F4F6V8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734285.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22665"/>
    <dbReference type="EnsemblBacteria" id="AEB45633">
        <property type="protein sequence ID" value="AEB45633"/>
        <property type="gene ID" value="VAB18032_22665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22665"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350184_0_0_11"/>
    <dbReference type="OMA" id="CIADREW"/>
    <dbReference type="OrthoDB" id="1790198at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="766" mass="81827" checksum="AF1C481092297F42" modified="2011-06-28" version="1">MTSGPQAHVDVVELRVHGVSGAGAEQILNRPHSYQVAGDGSGGFYRPHPDYPDAKGPAGVTLEAYRWSDLPSGTTVRTLSLMFLLPFMLCNVAIWMRPATQGTSGAGIKATCRLLALTLTMLYVLATMGVALDLIAVRCMSNPFCTANRPWLSWLSGRPTGLRLSVLALAPAAALGLVWRLGTRPGHNFDAFHRATNESKPHALSAVGQWDGAPLVGRLRSLHVAAGFATLSIGLLIARCFAGTSAPSVALTVVATAILGACVTMLCVQRWIDAPDSGRADRFCSFLRTAACVLTVMVLVVVAVDPTPWRSAVGLPGYSVMVGLVILAQTALLFTLGVAALATRGQLRDKVSVAGRARGGGIDPEESRRGFGCDGLGSGPLQGLGAPVIAATATGLALALTADLVFRVADLLNRRARADDERTVSAPLGFKWAIFVFLLAAVTVLVGAVVLNLASRSVRINSARATVARDFPHAPAAARHRLQQVEHTIARARFTERLETLAVIYAGVVGAGLPTILLGMLQLAPGHVVEQLTGIPEAATNFGIQVGSFLIAAVVLALLIGGIFAYRTAEFRRYVGVLWDLGTFWPRAAHPFAPPCYAERAVPELSRRITYLTEQGHGVLLTGHSHGAVLLAATVLQLPREVCGHLALLTYGSPLRRLYGRLFPAYVNEQVLLDVGRRVNWRWLNLWRDTDPIGGWVFSPHRPGRDPVLPGPPGTVDRRLRDPVDVVPPPGDSVPPQIIGHWPGEADPRFRAAVTDLADRLRNRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6W9</accession>
    <name>F4F6W9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease/ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_22720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734296.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22720"/>
    <dbReference type="EnsemblBacteria" id="AEB45644">
        <property type="protein sequence ID" value="AEB45644"/>
        <property type="gene ID" value="VAB18032_22720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22720"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="GMWRTQA"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="330"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="575" mass="58981" checksum="2F276045B0F6973C" modified="2011-06-28" version="1">MPTPTGPDRLLRRVVRDGGGWTVLLTMVALIGAAAELALPASLGFAVDAAVGGTASWWPAVACALVAILLTTDILGDVAAGYGAARATALLRRRLLRHLFACDVRTVRRYPVGDLVGRLVGQATDAGQAGTAVVFGVVALLPPVGSVVALTLIEPLLGLTLLGGLAVLAVLMRAFVTDASAAVTGYQRVLGAIAGRLLEALGGARTIAAAATVDQERDRVLSALPELRGYGLLGWRLLARASARTAAVGPLLQAAVVAVGGYALTAGWLTPGQLVAAMQYAALGAGLGAVLATLNRLVRARAAANRIAEPLAHPTRRYGDEPLPSGQGELRMRGVGVHGADGRPVLRDIDLLVPAGATLAVVGRSGVGKSTLAAVAGRLHDPDAGEVLLDGVPLHRLSPQALRRGIGQAFDRPVLVGETVHDAIGLALPDESAGPPAGAAPATAEVLAVARAAQVADVVARLPDGFRTRLTDAPLSGGEAQRLGLARAFPAQRLLILDDATSSLDTATEHRISRAVTEGVGGRTRLVVTHRAATAATADLVAWLDGGRVRAVGPHRRLWADPDYRAVFTPGGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7M2</accession>
    <name>F4F7M2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase sdr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733118.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16785"/>
    <dbReference type="EnsemblBacteria" id="AEB44461">
        <property type="protein sequence ID" value="AEB44461"/>
        <property type="gene ID" value="VAB18032_16785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16785"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OMA" id="AAWDERH"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="26760" checksum="84C694A64AF672E6" modified="2011-06-28" version="1">MSRFADQTVLVTGGTGGQGASHVRAFHAEGANVVIGGTNAERGAGLAAELGDRARFVRFDVSEEESWAAAVAETERAFGALTILVNNAGVQNPPALIESTDRATWARILDINLTGTFLGIKAAAPALRRAGGGTIINIASTMGIGGTAFYAPYVASKWAVRGLTRTAALELGRDNIRVNVIHPGVVATPFITEPAAGSDTAIADFYSPEPFAVPRLGEPADITALLLFLTSPDATFITGAEYVIDGGLLLGPALQKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7M9</accession>
    <name>F4F7M9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prcB</name>
        <name evidence="4" type="ordered locus">VAB18032_22830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734318.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22830"/>
    <dbReference type="MEROPS" id="T01.005"/>
    <dbReference type="EnsemblBacteria" id="AEB45666">
        <property type="protein sequence ID" value="AEB45666"/>
        <property type="gene ID" value="VAB18032_22830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22830"/>
    <dbReference type="eggNOG" id="COG0638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_2_0_11"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="OrthoDB" id="1129370at2"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005051103" description="Removed in mature form; by autocatalysis" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023311342" description="Proteasome subunit beta" evidence="3">
        <location>
            <begin position="41"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="266" mass="27731" checksum="661C5D72E36E765B" modified="2011-06-28" version="1">MFTNAGTSSFTSFLSKVAPEMLPGRRPLPPGMAADLAPHATTIVAISAAGGVVMAGDRRATMGNLIAQRDIEKVHPADAYSLVGIAGTAGIGIELMRLFQVELEHYEKIEGAMLSLDGKANRLASMIRGNLGAAMQGLAVIPLFAGFDLAAKDPARAGRIFSFDVTGGPYEETGYDAIGSGSLFARSALKKRFRAGLSIDDAVRLAVEALYDAADDDTATGGPDLTRRIYPVVMTATAEGTHRLTDAETSAIAESVVAGRMENPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7P1</accession>
    <name>F4F7P1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22890"/>
    <dbReference type="EnsemblBacteria" id="AEB45678">
        <property type="protein sequence ID" value="AEB45678"/>
        <property type="gene ID" value="VAB18032_22890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22890"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="PKYLFCD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="25681" checksum="4B70198C35434BF7" modified="2011-06-28" version="1">MWKVYGSGEAQVIALQGVSAEFERGRFTAIMGPSGSGKSTLMHCLAGLDTVTRGTVHVGDTTVTGLGDAGLTKLRRDKIGFIFQQFNLLPTLTAKENILLPLSIAGRKPDQAWYDIVIDTVGLRDRLDHRPAQLSGGQQQRVACARALVARPEVIFADEPTGNLDSRAGAEVLNFLRNSVREHGQTIVMVTHDPTAAAYADRVVFLADGQIVSELIEPTADTVLDTMKKLDTLTEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F826</accession>
    <name>F4F826_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="10" type="ordered locus">VAB18032_29651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29651"/>
    <dbReference type="EnsemblBacteria" id="AEB47001">
        <property type="protein sequence ID" value="AEB47001"/>
        <property type="gene ID" value="VAB18032_29651"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29651"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_4_0_11"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="8">
        <location>
            <begin position="110"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="31161" checksum="E7B17B025720508F" modified="2011-06-28" version="1">MAVAARELLAAGVTSARVEAELLAAYVLGVPRGRLAIADGFTDEQLDRYRALVDRRARREPLQHLTGNAAFRHLELAVGPGVFVPRPETELLAGWGIEQARRAARPRPLVVDLCSGSGAIALSVAQEVPDARVVAVERSSAALAWLRRNAADRAAAGDRAIEVVEADVTDPDLLAGLVGQVDVLLCNPPYVPQAVAVPPEVAGHDPAEAVFGGADGLTVIRPVIERAATLLRPGGQLGVEHDDTHGAAVPELLAEDGRYTAISAHRDLAGRARFATASRRADHPAAGPAGTWQTDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9F8</accession>
    <name>F4F9F8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein ArsR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732023.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11170"/>
    <dbReference type="EnsemblBacteria" id="AEB43352">
        <property type="protein sequence ID" value="AEB43352"/>
        <property type="gene ID" value="VAB18032_11170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11170"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_6_1_11"/>
    <dbReference type="OMA" id="PVPLYQA"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12037" checksum="D9D9CCEDC041EF6A" modified="2011-06-28" version="1">MSVPLYQAKAELFRTLGHPVRIRVLELLQDGPKPVRDLLAAIDVEASNLSQQLAVLRRAGMVTTYRDGALVMYALSTPDVADLLAAGRRILGAVLADRDGLLDELRAGGASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9H1</accession>
    <name>F4F9H1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44549">
        <property type="protein sequence ID" value="AEB44549"/>
        <property type="gene ID" value="VAB18032_17225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17225"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030169_1_3_11"/>
    <dbReference type="OMA" id="EPPGTRW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="35419" checksum="01D67F03E47846FC" modified="2011-06-28" version="1">MHDRLDHIRRAGQVGGLHAVAAVRGGHTVLEYYGAGEDFAWGDSLGVVEFGPETLHDIRSVTKSVTVLLYGMALGEGLVPPPAEPLLQRFPQYPDLAADPQRARLTVEHALTMSLGVEWREDLPYNSPANAEIAMELAPDRYRYILQRPILEPPGTRWTYCGGATALLGRLIADGTGQSLPQYAQAVLFAPLGIDSFEWMTGADAVASAASGLRLAPRDLARLGELVLAEGTWDGQRVVPADWIRTMLQPRLQTTWGAQYGYQWYIESIGGHRLLTGMGNGGQRLFVLPDLDLTAAITAGNYDDPHQWQTPLTVLEQVILPAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9L8</accession>
    <name>F4F9L8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bnr repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733251.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17470"/>
    <dbReference type="EnsemblBacteria" id="AEB44596">
        <property type="protein sequence ID" value="AEB44596"/>
        <property type="gene ID" value="VAB18032_17470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17470"/>
    <dbReference type="eggNOG" id="COG5184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_8_0_11"/>
    <dbReference type="OMA" id="WSWGTND"/>
    <dbReference type="OrthoDB" id="308036at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="411" mass="42488" checksum="24CB01F241437AC2" modified="2011-06-28" version="1">MKEHQEGRLRTRWRRAARTAVAAATAVVGITVLAVGLTAGAAAAGGSPADRGTSSASVAAAAVSQVATGDLHTCVIRTDGTLWCWGNNFNGQLGDGTTTSRTAPVRIGDATTWAQVDAGKSNTCAVRTDGTLWCWGANNNGQLGDGTTTSRTAPVRIGDATTWASVSTSNNHTCAVRTTGTLWCWGLNTHAQLGVGMTPLMSPTPLQVGTATTWARVATGYGHSCAVRTDGTLWCWGSSSDGQLGLGIMSYKTTPTQVGTATTWSAVTTGYVHTCAVRTDGTLWCWGENGYGQLGGGSGHQTTPLQIGTATTWARVEASIDSSCAARTDGSLWCWGRNTYGQVGDGTTTHRLAPTQVGTATTWTGSLAVSHHGCAVRTDGTLWCWGDNFLGQLGDGTTTGRTTPGQVVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9N3</accession>
    <name>F4F9N3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733266.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17545"/>
    <dbReference type="EnsemblBacteria" id="AEB44611">
        <property type="protein sequence ID" value="AEB44611"/>
        <property type="gene ID" value="VAB18032_17545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17545"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OMA" id="LEIAWLI"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="299"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="43004" checksum="289B9D547E2B4442" modified="2011-06-28" version="1">MEHRAGSRPLRVVAHDVVLALLVTVMQVQGTVAKVAVEGAPRPLTDFGNLGYALLVVSGLVLAVRRRWPVAVFVTAALASLVYYGLDFPDAPGWLGLFVALYTLAAYGDGRRSLVIAGVGVTVLAVGWLVAAADIEPQAAIGWVFFRIGASVMSAALGESVRSRRVIAADAQRRAELAERSREEAARARVDAERLRIAREVHDTVAHAIAIINVQSGVTAHVLDKRPEQAREALRAIELTSARALREMRTILGVLRDDHDSRVPQAGLEQVDELVAKAREAGLDVTVEASSPVASLPSAVDGAAYRILQEAFTNVIRHVGPTRVTVVLSAGVDVLEVRVTDEGRRTPPPGDGTDGRAEPGRGIVGMRERCQLLGGELDAEPTRRGGFEVRARLPLAPDGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9V4</accession>
    <name>F4F9V4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734532.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23910"/>
    <dbReference type="EnsemblBacteria" id="AEB45880">
        <property type="protein sequence ID" value="AEB45880"/>
        <property type="gene ID" value="VAB18032_23910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23910"/>
    <dbReference type="eggNOG" id="COG4385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102913_0_0_11"/>
    <dbReference type="OMA" id="RWVAMDH"/>
    <dbReference type="OrthoDB" id="1735705at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006521">
        <property type="entry name" value="Tail_protein_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09684">
        <property type="entry name" value="Tail_P2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="22473" checksum="E28F03A546223A14" modified="2011-06-28" version="1">MRRAGIERLLPAAYQRACVPGSVLWALLEVMEGLHAPDEAVLAEVDALFAPYRAPGEMVAYLARWVAMDHLVAAPRRDAPLPLPLSRLRDLVAHGAHLAAWRGTPDGLRTVLELATGVTGFVLDEPPDRPFHLVVRVPAAAADQVALIGRIVEAEKPAAVTAEVIVDSAPVVEPAPADRAVGRASVPSGPAVTEPAAVHPAVADPVDPAPEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA48</accession>
    <name>F4FA48_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">bPH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735804.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00375"/>
    <dbReference type="EnsemblBacteria" id="AEB47159">
        <property type="protein sequence ID" value="AEB47159"/>
        <property type="gene ID" value="VAB18032_00375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00375"/>
    <dbReference type="eggNOG" id="ENOG5031NQU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143522_0_0_11"/>
    <dbReference type="OMA" id="LIHAVFD"/>
    <dbReference type="OrthoDB" id="1682253at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012544">
        <property type="entry name" value="PHb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037063">
        <property type="entry name" value="PHb_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08000">
        <property type="entry name" value="bPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="13333" checksum="5E0F9D05295CC9CE" modified="2011-06-28" version="1">MANPTYDRKEQFQQIQSGLLDGEQIIAVYDAVGTGTGFIGLTDRRVIIQDRSFIGKRYAITSIPYSKITSVSVVSNKSWGGSFFSTGAIAIHVGTHTYEVEFRGDQKSHHVHNVILHYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA72</accession>
    <name>F4FA72_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, central region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730807.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05035"/>
    <dbReference type="EnsemblBacteria" id="AEB42133">
        <property type="protein sequence ID" value="AEB42133"/>
        <property type="gene ID" value="VAB18032_05035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05035"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_11"/>
    <dbReference type="OMA" id="YRGYRPV"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="35791" checksum="8C1A427A2B1A21E8" modified="2011-06-28" version="1">MATETLTLGKALNVGLRKALENDPKVVIMGEDVGKLGGVFRITDGLQKDFGDQRVIDTPLAESGIIGTAVGLAIRGYRPVCEIQFDGFVYPAYDQIVSQVAKMHYRSGGNLRIPMVIRIPFGGGIGAVEHHSESPEAYFAHTAGLKVVSCANPQDAYVMIQQAIASDDPIVFLEPKRRYWEKGQVDLDTPLTEAYPLHSARVVRPGTDATVLAYGPMVRTCLDAATAAAEDGRNLEVIDLRTLSPLDLAAVYESVRRTGRAVVVHEAPSNVGLGAEIAARITEECFYSLESPVLRVTGFDTPYPAARVEEEYLPDLDRVLDAVDRTFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA76</accession>
    <name>F4FA76_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730811.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05055"/>
    <dbReference type="EnsemblBacteria" id="AEB42137">
        <property type="protein sequence ID" value="AEB42137"/>
        <property type="gene ID" value="VAB18032_05055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05055"/>
    <dbReference type="eggNOG" id="COG3057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679507_0_0_11"/>
    <dbReference type="OMA" id="DHNIGIT"/>
    <dbReference type="OrthoDB" id="649993at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="406" mass="43503" checksum="5AEAB8744A51EDD5" modified="2011-06-28" version="1">MATPQTPYEAVLHAARDVTKLDTALDAEMLGAALLGSVYEVAETDRETAVREFVAGFLAATSRRRALAATTVRAVFAALVPDAKGADRVRPGAAAPAWSGHLGRVHLTGTWAYGDVYGDQTSYLATFAYDDTVGGPEHALIALVDHNIGIAKDVFVGGPASRILAQVRQLCAEDELTWFREEDPSRMRGEVSRHLAVTDHLGQLPGTTSLATDRALVGARLTILPAWQGAVPVPSDDPLPAAVRADEIRRFLASPEAKRAGFDDVDGAELASLHFCLGLLLDHAATFADADPLRWSPTVAGFFLLDWVHRRAVLDMDDAAMLPRVLRAWAAYAARRRGLPETAAAGTDTAIAEMVPEFVRLYATGERRSPATAAVAQLMADGVDPDDPAALDAWIDANRHRLSDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAJ4</accession>
    <name>F4FAJ4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="8" type="ordered locus">VAB18032_11535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732091.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11535"/>
    <dbReference type="EnsemblBacteria" id="AEB43421">
        <property type="protein sequence ID" value="AEB43421"/>
        <property type="gene ID" value="VAB18032_11535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11535"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_1_3_11"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="340"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="396" mass="41726" checksum="FD391D891F46D5E5" modified="2011-06-28" version="1">MKDYLLIVLALLGVLILGGIGLVVPRLRRRPAPPLPRTEVDTRTQEDLAGPPVEAPEAELSTGILVEPPPVVEAPTPTVEVPEPTAGRLVRLRSRLSRSQNAFGKGLLGLLSRDRLDEDVWEEIEDSLITADVGIDATREIVDRLRERTRVLGTRSAAELRALLAAELVNALDPELDRSLRTTPKEGVPAVLLVVGVNGAGKTTTCGKIARVLIADGRSVLLGAADTFRAAAADQLETWAGRVGAETVRGPEGADPASVAFDAVRRGIDTGVDTVLVDTAGRLQNKVGLMDELGKVKRVVEKHGPIDETLLILDATTGQNGLEQARVFTEVVNVTGVVLTKLDGTAKGGIVIAVQRKLGIPVKLVGLGEGPDDLAPFDPAQFVDALLGTEAPGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAP2</accession>
    <name>F4FAP2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733312.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17775"/>
    <dbReference type="EnsemblBacteria" id="AEB44657">
        <property type="protein sequence ID" value="AEB44657"/>
        <property type="gene ID" value="VAB18032_17775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17775"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_11"/>
    <dbReference type="OMA" id="PMNANIE"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="138" mass="14805" checksum="91D4F7A4591B3D88" modified="2011-06-28" version="1">MSGARVVAGKAVPRGRFPHVKVAGGFAFVSGTSSRRPDNTIAGATVDALGTTSLDIEVQTRAVIENMRDILREVGADLSDLVQVTTYLVSMNDFGGYNRVYAELFDETGPTRTTVAVHQLPHPHLLIEMQGIALLPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAP5</accession>
    <name>F4FAP5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetaldehyde dehydrogenase [acetylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:23288"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the acetaldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733315.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17790"/>
    <dbReference type="EnsemblBacteria" id="AEB44660">
        <property type="protein sequence ID" value="AEB44660"/>
        <property type="gene ID" value="VAB18032_17790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17790"/>
    <dbReference type="eggNOG" id="COG4569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062208_0_0_11"/>
    <dbReference type="OMA" id="MIKVIRH"/>
    <dbReference type="OrthoDB" id="1432332at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01657">
        <property type="entry name" value="Ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003361">
        <property type="entry name" value="Acetaldehyde_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015426">
        <property type="entry name" value="Acetylaldehyde_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09290">
        <property type="entry name" value="AcetDehyd-dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015689">
        <property type="entry name" value="Actaldh_dh_actl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03215">
        <property type="entry name" value="ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="159"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="31516" checksum="A4A1275719AA6F66" modified="2011-06-28" version="1">MSTGVAVIGSGNIGTDLMIKVLRLSESLRMVAMVGIDPDSDGLARARRLGVATTAAGVDGLVAMPEFADVGIVFDATSAGAHRHNDAVLRAHGRRVVDLTPAAIGPYVVPPVNLDAHLGERNVNMVTCGGQATVPIVAAVRRVTPVAYGEIVASISSRSAGPGTRANIDEFTETTARAIEVVGGAGRGKAVIVLNPAEPPLLMRDTVYCLCPDPDADRDAIAASVEAMVAAVQQYVPGYRLKQQVQFTEVDTYVPALGGHFVGIQVSVFLEVSGAGHYLPAYAGNLDIMTSAALRTAERMVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAQ2</accession>
    <name>F4FAQ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-amino-5-chlorophenol 1,6-dioxygenase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17825"/>
    <dbReference type="EnsemblBacteria" id="AEB44667">
        <property type="protein sequence ID" value="AEB44667"/>
        <property type="gene ID" value="VAB18032_17825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17825"/>
    <dbReference type="eggNOG" id="COG3384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946299_0_0_11"/>
    <dbReference type="OMA" id="VVFDVHW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="2">
        <location>
            <begin position="42"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="37006" checksum="B45D6204EF2540C9" modified="2011-06-28" version="1">MSRVFRVPVAPARSGGARRYDTTERPSAEPTPARAGIVAGVLSPHPPHLIYAENPPQNEPRSTGGWEVLRWAYERLRKRIREVHRPDVLIVHAPHWITMVGHHVNCVPNPRGVSVEPIFPHLFRYSYDFRTDVELGEAIADEATDLGLVTRKLHDPRVRVDYATIGALHLVNPAWDIPVVSLSANNNPYFYSEASLEEMEVLGEATRRAVERTGRRAVLLASNSLSHLHWHEEPELPEDMEREHPYNNHQYRWDMKLLEAIRRGPTAPLRELITEHIEATASETKAGSLTWMLAAMGWPQVPGDVMGYGTIIGTGNAVVEWTPEGGHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB09</accession>
    <name>F4FB09_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amylo-alpha-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24370"/>
    <dbReference type="EnsemblBacteria" id="AEB45972">
        <property type="protein sequence ID" value="AEB45972"/>
        <property type="gene ID" value="VAB18032_24370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24370"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019216_1_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="16"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="359"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="713" mass="78443" checksum="F487518F566E6DD2" modified="2011-06-28" version="1">MRNLRVRPDLLYVASGWSTLVTDVRGRITGVGAQGFFARNTRVLSTERITVDGREPVPFSTATVQGHAQLSYAELGDGEVLPSRAAYLAVERFVAAGLRTRLTLFSYAERRLDLRLRIRLDADFADTSEAESGRRIQSGAVEARWDPAGQELLLTYRCDGLDRAVAIRVQASGPIRYVDGGFDIDVMLSPGGVDLIDLAVEPIFDGQRLGAPAPSFAEPGDTAGSARRRLTAELARLTSTNFDVTAAWRCAREDLAGLPLGEPDGPTAPIAGLPIYQEIFGRDTMTASWQAMLAGPTMLADSLRLNARHFGRRVDDWRDEEPGKPLHEARQGPLSELNVNPFTHYHGDWSTAPDFLIFLGQYYAWTGDLDTVRELLPTADRALDWIDRYGDRDGDGFLEYHRRSRGGLKNQGWKDSDTAIVDEHGQVVPNPIATSEVQAYWYAALRHAAGTYAVAGHPVVAARLARRAAALRRRFHRVFWLPDRGCYAMALGPDKRPVRSVNSNDGHLLATGIVPPRIAPLVADRLLAPDMFSGWGVRTLSAAHPAYNPFSYHRGSVWPVEAGTIGLGLARYGCWEHLHRLAEGMFAASALFAEHRLPEVLSGLPRDDAHPHPGVYPSACSPQAWSASSVIALIQALLALRPAAPLRTVFVDPHLPAWLPDLVLEGVRVGGYTVDLTVRRRRGGRTSIRARGDRIAVVRRPTRQAIAARRQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB50</accession>
    <name>F4FB50_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735840.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47195">
        <property type="protein sequence ID" value="AEB47195"/>
        <property type="gene ID" value="VAB18032_00555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00555"/>
    <dbReference type="eggNOG" id="ENOG5031U83">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188863_0_0_11"/>
    <dbReference type="OMA" id="TGNYPYW"/>
    <dbReference type="OrthoDB" id="2073188at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="89" mass="9715" checksum="A6B2053036D08782" modified="2011-06-28" version="1">MTTPYPPPPPPPSRPAGRDRTTLWGVLGIVTGLLCCGILGIVFGWLSIRDARRYHQSPVLGYVAIGLGVLNIVLSLILQATGNYPYWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBD8</accession>
    <name>F4FBD8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_05540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730907.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05540"/>
    <dbReference type="EnsemblBacteria" id="AEB42234">
        <property type="protein sequence ID" value="AEB42234"/>
        <property type="gene ID" value="VAB18032_05540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05540"/>
    <dbReference type="eggNOG" id="COG4965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079642_1_0_11"/>
    <dbReference type="OMA" id="PPWDGLR"/>
    <dbReference type="OrthoDB" id="1835396at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="155"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="30835" checksum="F549AA557D9E2FCF" modified="2011-06-28" version="1">MNLHLFIAVVAGAAVGLGVFLVVRELVPATPALGPALRRLHPPAGVARPSPADRQLEWLTGLARWLRPPHRQLALLDRTPEQYTLSLLLSALIGLAAPALLSFALFAVGISLPLVVPVLGSLGLAALCALVAHRAVVTRAEAAREEFRQAVCTYLDLVALQLSAAHGPVQSLERAAAICDGWVFERISEALRMAQMQMHSPWDELRDLADRIGIPELGDVGAIMQSSGSEGAQVHETLRSRADSLRDQIRTDNLARAEGVTSRLDIPGALLVFVLLGFAIYPFLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBP0</accession>
    <name>F4FBP0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="7" type="ordered locus">VAB18032_11940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11940"/>
    <dbReference type="EnsemblBacteria" id="AEB43502">
        <property type="protein sequence ID" value="AEB43502"/>
        <property type="gene ID" value="VAB18032_11940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11940"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_3_0_11"/>
    <dbReference type="OMA" id="TEHRHYV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="6">
        <location>
            <begin position="81"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="18801" checksum="8BAEF07561F5A177" modified="2011-06-28" version="1">MIAPVVDSAGYDLEDLSVSRAGRRHVVRVIVDADGGINLDAVADVSRAVSAALDAAEESGGDIVAGEYQLEVSSPGVDRPLTLPRHWRRNVGRLVRVTVRGAGESGARPAGDRQVTGRVVAADDESVALEVDGERVQWPYADLGPGRVQVEFSRLDELPESEDVDDEDDVEDEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBS4</accession>
    <name>F4FBS4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome d ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_18110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733379.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18110"/>
    <dbReference type="EnsemblBacteria" id="AEB44724">
        <property type="protein sequence ID" value="AEB44724"/>
        <property type="gene ID" value="VAB18032_18110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18110"/>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_3_11"/>
    <dbReference type="OMA" id="RWWITND"/>
    <dbReference type="OrthoDB" id="271551at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB44724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="425" mass="46571" checksum="749EE99A8612BDD9" modified="2011-06-28" version="1">MDAVEISRLQFAVTGSVHYLFVTLSLGLVLFVVAFQTLWTIRKNPAYERMTKFWGRLYVINYGAGIIGGLVMEFQFGLNWSGLVHATGNVFGGLIAIETLVAFFIEATFLGMWIFGWGRIPRVLHLGLIWVVAATAYVSAYWILAANAFLQHPVGYEMRDGVAFLTDFSALLRNPNLVDALLHIVSAAVVTGALFVAGVSAWQFLRRTPDVAEFRRSLRFAVVALPLGVYPAIHFGFLQEVVIEQSQPAKLAAIYADPERSLRVQRELAAQFGPGDWIPPDWVSVPYQIMMQTTFGLALVSITLLVLLTRDWLVRLRVPLYVLVGLIPVPFVLVVCGWLVREVGRQPWAVYGLLSTTDAASPLSTGAAAASFAGFSVLLGGLVLLNVTLLWRFARRGIEDDALGMPLGAALGPSTSDDDTLLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBZ5</accession>
    <name>F4FBZ5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activator of hsp90 atpase 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24475"/>
    <dbReference type="EnsemblBacteria" id="AEB45993">
        <property type="protein sequence ID" value="AEB45993"/>
        <property type="gene ID" value="VAB18032_24475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24475"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1694240_0_0_11"/>
    <dbReference type="OMA" id="QTAVWGP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="16891" checksum="BB916F9F03258A0A" modified="2011-06-28" version="1">MTETPDLHLRLSRYLPASPEEVFDAYTDPEQQKIWFSILDEQPGIVEIETDLRVGGTQTAVWGPSRDQLFRETQTFLEIDRPHRLVTEAVGSSPDGATMTTHVEVTFAPDGDGTLVTVVQTGFPAAEMRDFFAHEVWVGALDRIEAFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC31</accession>
    <name>F4FC31_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator with aminotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734681.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24655"/>
    <dbReference type="EnsemblBacteria" id="AEB46029">
        <property type="protein sequence ID" value="AEB46029"/>
        <property type="gene ID" value="VAB18032_24655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24655"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_11"/>
    <dbReference type="OMA" id="HERRQVM"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="473" mass="50550" checksum="97063A251AC610C8" modified="2011-06-28" version="1">MGLSRTNSSTAADLLIDVDRSATEPLHRQIASSIRRSIRAGRLRLGTSLPPTRTVAADLGVSRGVVVEAYQQLAAEGYLTSRSGGYTRVAVDPAATPEDHRPGVPPAARIDFGYGRTDVSSFPRAAWLRSVRTVLTTTPSERFAYPDGRGVPELHAALADYLNRVRGTAARPENVVICSGYGQGVALLIQVLAARGARRLVVEDPSSDGDARPVAITAGLEVVGVPVGPDGIRVEELEHLDADAVVLTPSHQWPTGGVLSAAARTRVIGWAQRRRAVVIEDDYDAEYRYDRSPLGAMQGLAPDTVVYCGTASKTLAPGLRLGWLLAPAHLVDDLTAAKVLADRGSGVIDQLTFADFLTRGEFDRHLRRMRPIYRRRRDALVAALRTRLPELEAVGVAAGQHVVTWLPPDLDEATVVAAAARHGLVVQGISRYRLDPTGPGGLIFGYATLTERAIADGVQALAAAVSEARGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCH3</accession>
    <name>F4FCH3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730973.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05870"/>
    <dbReference type="EnsemblBacteria" id="AEB42300">
        <property type="protein sequence ID" value="AEB42300"/>
        <property type="gene ID" value="VAB18032_05870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05870"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_4_11"/>
    <dbReference type="OMA" id="ALMIRND"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="111" mass="11860" checksum="6479D3920E484BB6" modified="2011-06-28" version="1">MDRAELSITVHRTGDEAVLRLAGEIDMLTAAQLSTVVNEVLAEPPPRIVLDLGGVTFCDSQGLGTLVVLSRKASHAQSLLILTNVGEFLLRVLDITGLRSALMIRNDAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCY9</accession>
    <name>F4FCY9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, emrb/qaca subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18595"/>
    <dbReference type="EnsemblBacteria" id="AEB44821">
        <property type="protein sequence ID" value="AEB44821"/>
        <property type="gene ID" value="VAB18032_18595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18595"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_11"/>
    <dbReference type="OMA" id="FKIHTFS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="533" mass="56520" checksum="C4F0AAE5697DA7E8" modified="2011-06-28" version="1">MTQQSVAASQPVPTSDKLDAAVLKVAGVVVLGAIMSILDVTVVGVALPTFQSEFDASYARVAWTMTGYTLALATVIPLSGWAADRFGTKRLYMMALALFTIGSGLCATADTIGQLIAYRVLQGLGGGMLMPLGMTIMTRAAGPHRIGRLMAVLGIPMLLGPIGGPILGGWLIDVASWHWIFLINLPIGLVALAYAQKALPKDNPEPSESFDFLGMLMLSPGLALFLYGVSTLPETGTFADTGVWLPMLIGAALVVAFVIYSFRPRHPLLDLRLFRNRRLTVAAVTMFVFIIAFMGAGLLFPSYFLQVRGESTLAAGLLIAPQGIGAMLTMPIAGMLADKVPVGRTVPFALLLIIAGFATFTQIDANTSYVLICGSLFVMGLGMGGTMMPIMTSALRTLTGHEVARGSTLVNILQQIGGSIGAAVMSVILTNELNNSRPIPGVTDPNGNPITETGLAIAAQQQPELLQQFPVEPSLIERGLDFAADAFATTFWVAFGLVVLTLIPAAFLPRRRERSHLLDDQSGDQPKAPVVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD09</accession>
    <name>F4FD09_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_18695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733496.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18695"/>
    <dbReference type="EnsemblBacteria" id="AEB44841">
        <property type="protein sequence ID" value="AEB44841"/>
        <property type="gene ID" value="VAB18032_18695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18695"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="LFRYQPW"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="44"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="36485" checksum="EA46DAC8C21D63E3" modified="2011-06-28" version="1">MTGPDTVRSDPPAGQEALLSGQQDEASLGAAARLVAELPPAPAVWCSGLRKRYRRRTAVDGVSFTVDRGEVVGLLGPNGAGKTSVIKILLGLVRPDAGEVLLLGRPARDPRSRARVGYLPELFRYQPWLTAAEVLALHVRLAGADVPQRERQECLAAVGLTDRAGDRVGGFSKGMQQRLGLAVALVARPELVVLDEPTSALDPLGRADVRDLLLSLKARGVAVLLNSHLIGEVERVCDRVVILDRGRVAAAGTLAELLGRRELRLRLDGVTEPARDRLAAAGPLAQEGNLFTVTLPSEPEPTTVPQLVADLVGLGVRVHAVEPGRVSLEERLLAILRTAGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD31</accession>
    <name>F4FD31_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_18805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733518.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18805"/>
    <dbReference type="EnsemblBacteria" id="AEB44863">
        <property type="protein sequence ID" value="AEB44863"/>
        <property type="gene ID" value="VAB18032_18805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18805"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_11"/>
    <dbReference type="OMA" id="TVWAQTD"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="239"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="392" mass="41965" checksum="7631C773AB71E8CE" modified="2011-06-28" version="1">MTLTVPASTLDYFGIDSLIDDDTRQLQAAVREFVDRRIRPQIATWYDDGQLPARELAVELGELGVLGMHLQGYGCAGTSATAYGLACFELEAGDSGLRSLVSVQGSLAMYAIWRFGSEEQKQQWLPPMAAGAAIGCFGLTEADFGSDPSGMRTRARRDGSDWVLTGTKMWITNGSIADVAVVWARTDEGVRGFLVPAGTPGFTTAEITRKQSLRASVTSELVLDDVRLPADAMLPAAAGLSGPLSCLNEARFGIVFGALGAAHDCLQTTVEYARSRQIFDRPLAAYQATQLKLADMSLELGKGMLLAMHLGAAKDAGTLDHRQVSLGKLNSVREAIAIARECRTILGAAGITLDYPVIRHAANLESVLTYEGTSEVHQLIIGQVLTGHSAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD82</accession>
    <name>F4FD82_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PG_binding_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734764.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25070"/>
    <dbReference type="EnsemblBacteria" id="AEB46112">
        <property type="protein sequence ID" value="AEB46112"/>
        <property type="gene ID" value="VAB18032_25070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25070"/>
    <dbReference type="eggNOG" id="COG3342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068244_0_1_11"/>
    <dbReference type="OMA" id="CHPWAGG"/>
    <dbReference type="OrthoDB" id="1771686at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010430">
        <property type="entry name" value="DUF1028"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014927">
        <property type="entry name" value="PG-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06267">
        <property type="entry name" value="DUF1028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08823">
        <property type="entry name" value="PG_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_2" evidence="2">
        <location>
            <begin position="208"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="313" mass="32097" checksum="92042E51CA87BA30" modified="2011-06-28" version="1">MTFSLVARSADGHLHGVAVASRFLAAGALVPAAEAQVGAIATQAHVNLAYRPQGLALLRTGVTAAGVVAGLVAADPERDHRQVGVVAATGPGATYTGEHCRDWAGGQAGDGWAAQGNILTGPEVIDALRDTWLARTNLPFAQRLLAALRAGQQAGGDRRGQQSAGLVVVRRGGGYGGTGDLMIDLRVDDHPDPITELDRLLAVHTLMFSRPDPATLLDLTGAVAAEVAGLLTALGHPADPADPQDALVEWAGLENLEERLAPGRIDPVVLARLRAALPHVPAPRGTASTNRDPAVGAGGDFAASMGSEPESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDF9</accession>
    <name>F4FDF9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01430"/>
    <dbReference type="EnsemblBacteria" id="AEB47370">
        <property type="protein sequence ID" value="AEB47370"/>
        <property type="gene ID" value="VAB18032_01430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01430"/>
    <dbReference type="eggNOG" id="ENOG5032EM1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703874_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="392" mass="40694" checksum="D02A4113B47E47DB" modified="2011-06-28" version="1">MPNAAPYAARRSAPEPVPPAEPGNGRSPDRTSAVLPQRVPAEPDVPVVPEPPAVEPPAETPELARIATHLRRDDEPAPLRERPEGFDVDAIIDAVRGVDGVRGALLRRTPAGAHSLRLDLADGADPAEVSRQVARLLQERMGLAAAPQGVPGVPAAPVRRRSADNRGGDGEGRSTGEPRRPTNRPAGARAETVAARTEPATEQFRRRRPAPAPQRGRATVEETGPTGSPATLGSSYSGGQLTTTESAPSRPLDTGGRPGPRVVLDHVQVSTFGLDATVEVRLIAGEQSAAGYATGPAVDGYVLRLCAVAAAASIDELLRGAGGTAERGRCFVEHAAVVPFGNCEVATVVVLLVCDGWVEQLAGSALVAGDPRQAVVRATLAAVNRRLEALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDM0</accession>
    <name>F4FDM0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system F domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_06295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731056.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06295"/>
    <dbReference type="EnsemblBacteria" id="AEB42383">
        <property type="protein sequence ID" value="AEB42383"/>
        <property type="gene ID" value="VAB18032_06295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06295"/>
    <dbReference type="eggNOG" id="COG2064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064089_0_0_11"/>
    <dbReference type="OMA" id="IWIAIAT"/>
    <dbReference type="OrthoDB" id="2079512at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="118"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="26100" checksum="9F0B4A3C822DB98E" modified="2011-06-28" version="1">MSGTALAVGCLACAALLAAMAVSRRRPRRRLRRLTGHDPATVDRAPDSARTPTSRRLDRIRLAAALSGVAVAVLVEGWPGVVAALVTAVLLDRQLRRIELPAVRNRRLRAAADLPLAADLMAAALRAGAPVERSVIAVADALGGPLADQLRRVGRTLQLGGLPQEAWAHLAEVPGGQRIATAAVRSASSGAALAGALVRLADDLRADRVTTIEAAARRSGVLIVLPLGLCFLPAFILAGLVPVIVAVLGDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDM5</accession>
    <name>F4FDM5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731061.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06320"/>
    <dbReference type="EnsemblBacteria" id="AEB42388">
        <property type="protein sequence ID" value="AEB42388"/>
        <property type="gene ID" value="VAB18032_06320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06320"/>
    <dbReference type="eggNOG" id="COG4894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1412529_0_0_11"/>
    <dbReference type="OMA" id="QYEVHAV"/>
    <dbReference type="OrthoDB" id="1343711at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="21946" checksum="BFC3F9A02571718D" modified="2011-06-28" version="1">MQLDSLQSQHQFHVRQRIRLMVNQYEVHSVAPDGTEGGLLAFAQQKRLAFKEQVTIYTDDSKQHPLLGFKARQRLDLAATYDVTDHAGNPIGLFRKDFAQSLLRSTWHVEQAGLPAVTGQERSMPVALLRRFVDSLSWLPYHFDFVAGGQPVFSVIKKWGLRDRYVVQIQHPQIDRRLVIAMAIALDALQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDP8</accession>
    <name>F4FDP8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06435"/>
    <dbReference type="EnsemblBacteria" id="AEB42411">
        <property type="protein sequence ID" value="AEB42411"/>
        <property type="gene ID" value="VAB18032_06435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06435"/>
    <dbReference type="eggNOG" id="ENOG5033FCB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701962_0_0_11"/>
    <dbReference type="OMA" id="PARLHEY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="42839" checksum="DDB00274358F5E08" modified="2011-06-28" version="1">MLLLSVPGDWTGIWPEAGIAAQTPAFFLSVVAAGAAAWISGSSRRHRMEEQIAPMRVSARRQEAVRFLVTHVLLLVPYLSTAAVTYVISLVTISAPGQHLWLGYMLMGVLVMVLATTWGWLAGRHLSPVFSALLALLTWFLFLAYVSDRAEFIASSGPPWRTPDAAVMLMRAAAVVLLLAVVVATPRTFAVSPSKPRVQLLPGVALGLVIIAILGQKGIVDRAPPQRALCLPDRIVVCLWPEHEKFAPMIKGMVARAEGLPNGFVLPARLHEYGIQVVDTPYGRQQTGDIDISEGRASALAVGLASAITSTTFDGCDWDAMAEKNEYTPDALRRWLELHLTETDSPDYTTFGASGQLHAAWALAAQVYTERSSREQQTWVTTEITRLRHAYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDU8</accession>
    <name>F4FDU8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="4">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_12575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12575"/>
    <dbReference type="EnsemblBacteria" id="AEB43629">
        <property type="protein sequence ID" value="AEB43629"/>
        <property type="gene ID" value="VAB18032_12575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12575"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_1_11"/>
    <dbReference type="OMA" id="RVDGYWE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="28548" checksum="7ACED23755B7621B" modified="2011-06-28" version="1">MMDRSSAPELLEIAVDVARDAAATAYRMRAEGVSVTATKSTVTDVVTAADRAVERQISDALRRLRPDDAMLGEEYGAAGPGSDASTRVRWIVDPIDGTVNYLYGLAHSAVSIAAEVDGEVVAGVVRNIHTGEEWTATLGGGAWRDGRQLRCSTETDLGQTLVITGFGYDPARRAHQARVVAELIPHVRDIRRLGAAAIDLCLVAEGRADAYYEKGLAAWDQAAGALVAAEAGLRVGGLGGRVPGPDMVIAAPPAIFAPLHDRLVDLDADGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE46</accession>
    <name>F4FE46_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733570.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19065"/>
    <dbReference type="EnsemblBacteria" id="AEB44915">
        <property type="protein sequence ID" value="AEB44915"/>
        <property type="gene ID" value="VAB18032_19065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19065"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142180_1_0_11"/>
    <dbReference type="OMA" id="QEYRDLW"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="14781" checksum="6A91B5E6103DBF1F" modified="2011-06-28" version="1">MDREQVTGWISAYEQAWRTPGTQALATIFTEQASYRQGPYREPVIGLPAIARMWEAERDGTDEVFQMTSEVVAVEGDTAVARLEVRYGAPVDQEYRDLWIMRFAADGRCASFEEWPFWPAQSTATHPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEL6</accession>
    <name>F4FEL6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736092.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01870"/>
    <dbReference type="EnsemblBacteria" id="AEB47458">
        <property type="protein sequence ID" value="AEB47458"/>
        <property type="gene ID" value="VAB18032_01870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01870"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065571_0_0_11"/>
    <dbReference type="OMA" id="EVMVWTD"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="28173" checksum="7C01972718F81542" modified="2011-06-28" version="1">MLLSTSSVFPERTAAAFQLAAELGYDGIEVMVWTDAVSQDAGALRGLAEHYGVPVLSVHAPCLLVTQRVWSPDPWERLRRSAVLAETLQAPTVVVHPPFTWQRDYARTFADGLDKVTGEFGGLHIAVENMYPVRMAGRQFVPYAPGWDPTEVGYPSYTLDLSHCAASHTDALAMADRMGAGLAHVHLGDGTGEGRDEHLVPGRGGQPCAELLRSLAGRGFTGSVAVEVTTRGAKSRQVREADLRQSLAFAREHLSAASPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEZ6</accession>
    <name>F4FEZ6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoglucanase</fullName>
            <ecNumber evidence="7">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_12970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732376.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12970"/>
    <dbReference type="EnsemblBacteria" id="AEB43708">
        <property type="protein sequence ID" value="AEB43708"/>
        <property type="gene ID" value="VAB18032_12970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12970"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008926_0_0_11"/>
    <dbReference type="OMA" id="RWLDYWT"/>
    <dbReference type="OrthoDB" id="1226595at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001956">
        <property type="entry name" value="CBM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036966">
        <property type="entry name" value="CBM3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018221">
        <property type="entry name" value="Glyco_hydro_9_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00942">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01067">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51172">
        <property type="entry name" value="CBM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00592">
        <property type="entry name" value="GH9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3 5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM3" evidence="10">
        <location>
            <begin position="519"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="674"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="775"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="11">
        <location>
            <begin position="862"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="749"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="972" mass="104266" checksum="245C8D306307F91B" modified="2011-06-28" version="1">MHHTRRPRRARGDEPGHHQPWSRRLRTAGTALATGLALVLGVPAAGVAAPTSGDASTSAAAPAFNYAEALQKSLLFYEAQQSGKLPDWNRVSWRGDSGLRDGSDVGIDLTGGWYDAGDHVKFGFPMAFTTTMLAWGAVEYRSGYAASGQLTHLLNNLRFVNDYFVKAHPSPNVLYGQVGKGDDDHKWWGPAEVMPMARPAYKIDASCGGADLAGETAAAMAASSMVFRPTDAAYADKLLTHARQLYTFADTVRKNYHECITDATSFYRSWSGYTDELVWGAIWLYRATGDAAYLAKAESEYDKLGTEPQTTTRSYKWTVAWDNKQFGAYVLLANLTGKQKYIDDANRWLDFWTVGVNGERIRYSPGGMAVLDSWGALRYAANTAFAALVYSDKTTDATRKARYKDFAVRQINYALGDNPRNSSYMIGFGANSPKNPHHRTAHGSWWDSMTVPTETRHTLYGALVGGPSSPNDAYTDNRSDYVMNEVATDYNAGFTSALARLTQEYGGTPLANFPVAEQPDIDELTVETTVMQNETRATGLKVMIYNKSAFPARALTDAKFRYYFRPDGTGPVTVTPGYTQGCPAPSTARQAAGDLWYVEVDCTGHTIAPAGQSQHRMEVQFKVGVPEGGTWNTANDPSFQATAGPNRNVPLYAGGARVWGQEPTTAADTTPPTTPGTPVATAVTSRSVSLTWPASTDTESGIEDYSVSIRQVGSDAILLRTSATNSVTIDSLTPARTYVFSVQARDRAGNRSATSPSLTVTTPAVDEGDTTPPTAPGSLTVSGITANGAALTWTPSTDNVGVTGYRIYRTHLGAELVATVTGTTYQVTGLNPQTTYYFYVVGIDAAGNASPPSELVTVTTSAPLPTSPCRITYGTNDWGTGFTANITIANTGTTAINGWTLAFTFPHSGQRVGQSWSATFQQTGTSVTATNLSYNGTIAPGASTSIGFNGTHTGSNPRPTSFTLNGNTCTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF16</accession>
    <name>F4FF16_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732396.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13070"/>
    <dbReference type="EnsemblBacteria" id="AEB43728">
        <property type="protein sequence ID" value="AEB43728"/>
        <property type="gene ID" value="VAB18032_13070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13070"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_0_11"/>
    <dbReference type="OMA" id="WYMYLAD"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="430" mass="46012" checksum="AD6AEFA498B17E15" modified="2011-06-28" version="1">MTTHVSRRSLLGLAGAGVGAVLLGGCADDEPSGPTSPQQIDWWHIQNTDPMLPVWAEMARLYTTRHDKITIEVNPLENEVFKAELAKVTKAGSPPDLFQSWGGGLLREQAEAGLVKDITSEVSPWIGQLLPAALQPYTIDGRIYGIPFDIGMIGFWYNRDLFAEAGITSPPTTWAQLLTTVQKLKSAGIVPIALAGKDKWPGHYYWAYLAMRIGGLGALRQAAEDGNFNTPDFVAAGEHFRQLIDLQPFQPGFRRAEYGSSNGQAAAMGNGEAAMELMGQWAPSIQASSSTSKLGIGGQLGFFTFPTVEGGKGEATDAFGGGNGFAVGRNAPPATVDFLRSLLRSENQRWAAETGAVLPTNLAAVGRIKDPNNQVVAAHLAVASGFQLYLDQAFPPAVGEQINKSVADLIVGSKKPEQIVKDITRVAQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF29</accession>
    <name>F4FF29_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732409.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13135"/>
    <dbReference type="EnsemblBacteria" id="AEB43741">
        <property type="protein sequence ID" value="AEB43741"/>
        <property type="gene ID" value="VAB18032_13135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13135"/>
    <dbReference type="eggNOG" id="ENOG5032YSE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185993_0_0_11"/>
    <dbReference type="OMA" id="QGWSWQA"/>
    <dbReference type="OrthoDB" id="1850835at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="78" mass="8645" checksum="7B1DA2A86E1BF5A2" modified="2011-06-28" version="1">MSQATELAAAAGSTDPRVGLRAVRALRRLLERLEVVQVDNARRQGWSWQEIADALEVSRQAVHKKHAGRPAVESSWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFF2</accession>
    <name>F4FFF2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase A</fullName>
            <ecNumber evidence="6">4.2.1.3</ecNumber>
            <ecNumber evidence="7">4.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">(2R,3S)-2-methylisocitrate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Probable 2-methyl-cis-aconitate hydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ordered locus">VAB18032_25780</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="6"/>
    <dbReference type="EC" id="4.2.1.99" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25780"/>
    <dbReference type="EnsemblBacteria" id="AEB46254">
        <property type="protein sequence ID" value="AEB46254"/>
        <property type="gene ID" value="VAB18032_25780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25780"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013476_2_1_11"/>
    <dbReference type="OMA" id="NGGIMQY"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="19">
        <location>
            <begin position="65"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="20">
        <location>
            <begin position="746"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="395"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AEB46254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="946" mass="101023" checksum="810F05E7A9F9D38D" modified="2011-06-28" version="1">MASLDTFGAKTQLRVGDASYEIFKISQVEGHERLPYSLKILLENLLRTEDGANITAEHIRQLGAWDPNADPNVEIQFTPARVLMQDFTGVPCVVDLATMREAVRDLGGDPTKVNPLAPAELVIDHSVIADLFGREDAFERNVELEYARNKERYQFLRWGQTAFNEFKVVPPGTGIVHQVNIEYLARTIMERNGQAYPDTVVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLSGEMPAGTTATDLVLTITEMLRKHGVVGKFVEFYGPGVSAVPLANRATIGNMSPEYGSTVAIFPIDAETVRYLELTGRDASQVALVEAYAKEQGLWHDPAAEPDYSERLELDLSTIEPSLAGPKRPQDRVPLGSAKTLFRAALTDYVAADETGGDPGREPGVPQQETPFGTAGPADEASAESFPASDSPANGVNDPADAPRDLVTAAVGAGGRASNPIRVTGEDGNTYELDHGAVVIAAITSCTNTSNPQVMIGAALLARNAVDKGLNRKPWVKTTLAPGSKVVMDYYERAGLTPYLEKLGFHLVGYGCTTCIGNSGPLPEEVSAAVNEADLTVVSVLSGNRNFEGRINPDVKMNYLASPPLVVAYALAGTMDIDLANEPIGEDSEGNPVYLRDIWPSTAEIQDVIASAIGATGFSAAYADVFAGDERWQSLPTPTGDTFAWDGDSTYVRKPPYFEGMAQQPTPVTDIAGARVLAKLGDSVTTDHISPAGSIKADSPAGEYLAAHGVPRHEFNSYGSRRGNHEVMIRGTFANIRLRNQLVPGVEGGYTVNHLTGEQASIYDASMAYQAADVPLVILAGKEYGSGSSRDWAAKGTMLLGVKAVIAESYERIHRSNLIGMGVLPLQFPAGENADSLGLTGTETFTVTGVTALNDGSTPRTVKVTTDSGVEFDAVVRIDTPGEADYYRHGGILQYVLRRMIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFF4</accession>
    <name>F4FFF4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734908.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25790"/>
    <dbReference type="EnsemblBacteria" id="AEB46256">
        <property type="protein sequence ID" value="AEB46256"/>
        <property type="gene ID" value="VAB18032_25790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25790"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_3_0_11"/>
    <dbReference type="OMA" id="EGREATN"/>
    <dbReference type="OrthoDB" id="1811015at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="128" mass="13575" checksum="FB047C0C13C78198" modified="2011-06-28" version="1">MTVQGEPADHQWVDDHAGPVVRPYAVTGGRARPVTGTFDLISLVMATRTDVSPEIGLGPEHLAIVGLCQRMQSVAEIAAHLDLPVGTVRVLLGDLVARSLVQIREPHGTVGVPDNSIFEAVINGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFG5</accession>
    <name>F4FFG5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734919.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25845"/>
    <dbReference type="EnsemblBacteria" id="AEB46267">
        <property type="protein sequence ID" value="AEB46267"/>
        <property type="gene ID" value="VAB18032_25845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25845"/>
    <dbReference type="eggNOG" id="COG3220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064263_0_0_11"/>
    <dbReference type="OMA" id="EWDTDVP"/>
    <dbReference type="OrthoDB" id="1602134at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="28685" checksum="CACD8AAA6D0F81BD" modified="2011-06-28" version="1">MTGPHGVGIGWRPEIAGFVAELPGLRFVEVIAESVPTTGPPPDALVELRQRGVTVVPHGVRLSLGGAEPVEPARVAHLAAVAELLAAPLVSEHIAFVRAGGLEAGHLLPLPRTREAVDAVCANVARAQAELPVPIALEPIAALFDWPDDELDEAAFLSEILARTDALLLLDIANVHANAVNRGTDPLALLDRLPLERVAYLHVAGGAEQGGFYHDTHTDPVSPAVLDLLTELCARHRPPAVLLERDGRYPPAPELRAELDAVAAATGFPLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFK9</accession>
    <name>F4FFK9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_02010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02010"/>
    <dbReference type="EnsemblBacteria" id="AEB47486">
        <property type="protein sequence ID" value="AEB47486"/>
        <property type="gene ID" value="VAB18032_02010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02010"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="KHGAQGY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="22482" checksum="14C3EAB3ED05B14D" modified="2011-06-28" version="1">MTDPVRLLIVDDHPVVRDGLRGMFTGDPGFEVVGEAADGAEALALAARHRPDVVLMDLRMPGMDGVTAIGRLVRSGSTAKVLVLTTYDTDADVLPAIEAGATGYLLKDAPRDELVRAVRAAARGESVLSPAVAGRLMGRLRAPAEEPLSQRELEVLTLVARGSTNREAAAQLFISEATVKTHLLHVYAKLGVNDRAAAVAVAYDRGLLTPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFP4</accession>
    <name>F4FFP4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736155.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02185"/>
    <dbReference type="EnsemblBacteria" id="AEB47521">
        <property type="protein sequence ID" value="AEB47521"/>
        <property type="gene ID" value="VAB18032_02185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02185"/>
    <dbReference type="eggNOG" id="COG3557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120820_0_0_11"/>
    <dbReference type="OMA" id="AWWTGMF"/>
    <dbReference type="OrthoDB" id="1473648at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="56"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="168" mass="19123" checksum="6190C5F570AD71F7" modified="2011-06-28" version="1">MPSDVVRVIYRKYDGSAHRDYPARRLAEDDLGIWLGVPAGTSSVYHGRPSVEQIPFVLLVPHQAWWTGMFNPPPRTSEVYCDIATPARWEGEETVHLVDLDLDVVRRRETGLVELRDEDEFAEHRARFGYPDDLVVEAEAASRWLLTALGDGTEPFATSYRKWLALVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFW1</accession>
    <name>F4FFW1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopantetheine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07085"/>
    <dbReference type="EnsemblBacteria" id="AEB42541">
        <property type="protein sequence ID" value="AEB42541"/>
        <property type="gene ID" value="VAB18032_07085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07085"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2738927_0_0_11"/>
    <dbReference type="OMA" id="WKNIFGR"/>
    <dbReference type="OrthoDB" id="2101325at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="71" mass="7877" checksum="E7F0AB77B1C48C59" modified="2011-06-28" version="1">MLDIWKNIFGRQVGPDTDFFDDLEGDSMAAAAIVHWVNIVFGVQLPMIEVFDRPTPSELTGAVDELRAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG39</accession>
    <name>F4FG39_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732450.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13355"/>
    <dbReference type="EnsemblBacteria" id="AEB43783">
        <property type="protein sequence ID" value="AEB43783"/>
        <property type="gene ID" value="VAB18032_13355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13355"/>
    <dbReference type="eggNOG" id="ENOG50333WV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767094_0_0_11"/>
    <dbReference type="OMA" id="YLWYNGS"/>
    <dbReference type="OrthoDB" id="1243071at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313016" evidence="1">
        <location>
            <begin position="30"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="362" mass="38397" checksum="908AAF4CA14885DE" modified="2011-06-28" version="1">MRLRSFVSTALAAVLAAAGALMPMAPAAAATADRWGFAYVKDPTVPAWTVLDTTRQWGSWKTAFPTAWAQGAKLAPGLFQVRFPQVGAGPRGVPHVTPVNRSGHYCEVVRWGQSGADQIVEVQCHRPGGAREDTPFTVLWTTSSGVLPAGNSYAYVQWAGGALTQSYNSTGMANAAGAFGVGQYAVRLPGVGLPDLLAGNVQVTAVQPNALPRRCKVNSWGPVSTYVQVEVFCYDQAGAFTNTDFVLSYHRRRSVIGSFGPPNYIGYLGTAVGGPTNDNSMVGVGANTVVPVAPTGRFLATFPQLGVRETHAQVVAQGPGSNYCHLTQPWSYTTDAEVDVICFDNAGVITPHRFLATFTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG44</accession>
    <name>F4FG44_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732455.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13380"/>
    <dbReference type="EnsemblBacteria" id="AEB43788">
        <property type="protein sequence ID" value="AEB43788"/>
        <property type="gene ID" value="VAB18032_13380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13380"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_7_2_11"/>
    <dbReference type="OMA" id="MTAWTER"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="30554" checksum="312CB35C75A79CE1" modified="2011-06-28" version="1">MKVGVILPSLTIQRRDSLDLAAAARHAEDAGLDSVWHGDHLAVGMPTVDCTIALAVAATATARIRIGASVFIPAIRPLVWAAKQVASLQLVSGNRLLLGVGSGGGAAQWAAAGVAFRERGPRTDTALRLLPGLLAGESVTTPDGSVVTLSPGVEVPPLWVGNASTVAIDRAARLGDGWFPSLITPTALAQGRARLDGVAVAAGRPVPTVTIGATGALGDAPGTPSRAELAAGLAGAYRHTARDAEELPITGGPDEAAERLAEYAAHGANHVVIGLSGPDWRAQVDLLAEVRRRLPGPGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG71</accession>
    <name>F4FG71_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Excinuclease abc subunit a uvra1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732482.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13515"/>
    <dbReference type="EnsemblBacteria" id="AEB43815">
        <property type="protein sequence ID" value="AEB43815"/>
        <property type="gene ID" value="VAB18032_13515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13515"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_2_1_11"/>
    <dbReference type="OMA" id="VCFEGTV"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="488"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="522"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="794" mass="84184" checksum="D74068405FC0DBD4" modified="2011-06-28" version="1">MSRTTSAGAPSSHVADSHDLIRVHGARENNLKDVSIEIPKRRLTVFTGVSGSGKSSLVFGTIAAESQRLINETYSAFVQGFMPTLARPEVDVLDGLTTAIIVDQERLGANVRSTVGTVTDANAMLRILFSRLGQPHIGSPQAFSFNVASISGAGAVTIERGGATTKERRSFTVTGGMCPRCEGMGRISDFDLSALYDDSKSLNEGALTIPGYSVDGWYGRIFSGSGFLDPDKPIRKFTKRELNDLLYKEPTKIKVDNINVTYEGLIPRIQKSFLSKDREAMQPHIRAFVDRAITFGTCPDCGGTRLSELARSSKIDGRNIADLCAMQISDLAEWVRSLDAPSVAPLLTSLGHTLDSFVEIGLGYLSLDRPSGTLSGGEAQRTKMIRHLGSSLTDVTYVFDEPTVGLHPHDIARMNDLLLRLRDKGNTVLVVEHKPETIAIADHVVDLGPGAGTAGGSVCFEGTVEGLRGSGTLTGRHLDDRASLKESVRTATGALEVRGAATHNLRDVDVDIPLGVLVVVTGVAGSGKSSLIHGSVSGRDGVVAVDQTPIRGSRRSNPATYTGLLEPIRKAFAKANGVKPALFSANSEGACPTCNGAGVIYTDLAMMAGVATTCEDCEGKRFQPAVLEYHLGGRNISEVLAMSVTEAEAFFGTGEARVPAAHAILARLVDVGLGYLSLGQPLTTLSGGERQRLKLATHMAEKGGVYVLDEPTSGLHLADVEHLLGLLDRLVDAGKSVIVIEHHQAVMAHADWIIDLGPGAGHDGGRVVFEGTPADLVATRSTVTGEHLAGYVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGD4</accession>
    <name>F4FGD4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_19850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733727.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19850"/>
    <dbReference type="EnsemblBacteria" id="AEB45072">
        <property type="protein sequence ID" value="AEB45072"/>
        <property type="gene ID" value="VAB18032_19850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19850"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034528_0_0_11"/>
    <dbReference type="OMA" id="FPYPVYA"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309329" description="Phosphate-binding protein PstS" evidence="4">
        <location>
            <begin position="28"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="44"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="359" mass="36994" checksum="E08043855AF9B3F1" modified="2011-06-28" version="1">MNRNVLSRRVLAGVALAALALTGCASNDNSTEPGSNSGGDSAYANLSGELKASGASFPDAYYQEVIEAFKGEAGKVTVTYNATGSGTGKKQFGEGLVDFAGTDSLVKDTDGVAAGSFLYVPTVAAPITVSYNLQGVDKLQLSPETLAKIFQTDIKTWDDAAIKADNPGVTLPSTPIVVAHRSDGSGTTSNFTKYLDAAAAGTWKLGSGDTVNWPASTQGGEKNTGVAQIVQQTNGAVGYVDLSDAKATGLKFAAIKNKDGQFVEPTLEGTTAGLEGAEIAADLSYNPLNAAGATSYPITAPTFIIVKTSYGDAAKAELVKGFLKYLLNDGQDLAKEIDFAPLPASLKEKALAQVDKIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGS1</accession>
    <name>F4FGS1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736214.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02485"/>
    <dbReference type="EnsemblBacteria" id="AEB47581">
        <property type="protein sequence ID" value="AEB47581"/>
        <property type="gene ID" value="VAB18032_02485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02485"/>
    <dbReference type="eggNOG" id="COG5516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087298_1_0_11"/>
    <dbReference type="OMA" id="SRTCGNR"/>
    <dbReference type="OrthoDB" id="1770002at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="20056" checksum="1EE5BB98839CABBF" modified="2011-06-28" version="1">MPFAHDTESSLIATAALVNTAGQGDEGLPDVAALNDFFTVHSYSGRHEHTEAELRAVRALRPRLRRIWHADVDEIVSIVNGLLREHRALPQLITHDDEPYHLHAVPRDAPLATRMAVEAAMAIADVVRGGELRRLRTCEYPDCDNVLVDLSKNRSRRFCEAGCGNRAAVNAYRARKAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGV0</accession>
    <name>F4FGV0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_02630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02630"/>
    <dbReference type="EnsemblBacteria" id="AEB47610">
        <property type="protein sequence ID" value="AEB47610"/>
        <property type="gene ID" value="VAB18032_02630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02630"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_2_11"/>
    <dbReference type="OMA" id="DVCADWL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="109"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="4">
        <location>
            <begin position="229"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="373" mass="38287" checksum="F37D64BF34BE9E77" modified="2011-06-28" version="1">MAARAAEHDQAGSFPADDFADLRAAGLFGLMVPAELGGAGATFAEYAAVATELARGNGATALVFNMHASVTGALGAVTEELAEALGVPPEALAARDRLLRAAADGAWYAVAMSERGAGARLSQLSTVYEPVDGGWRIKGSKTFCSGAGHADGYLVAARSATDPSIVSQFLVPAGEGLTVEPTWDSLGMRATASHDLHLDVTVPADRLLGGVEGLALVVAQLMPHWLVASYAAVYVGVARAAIDAAAEHLNARNLAGLPAVRARLGRADAAVAAAQLTVAEAARRVDEAPGDAETNRWVWRAKLLAGTTAADVAASVLEAAGTSATRRGHPLERLYRDARCGSLHPATSDVCADWLGVAALGGDPDREGSAPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGV7</accession>
    <name>F4FGV7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="4" type="ordered locus">VAB18032_02665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02665"/>
    <dbReference type="EnsemblBacteria" id="AEB47617">
        <property type="protein sequence ID" value="AEB47617"/>
        <property type="gene ID" value="VAB18032_02665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02665"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_4_2_11"/>
    <dbReference type="OMA" id="KAREGCM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="20272" checksum="D2C8AE62809A68DF" modified="2011-06-28" version="1">MSGQVGGPDLDPQTPTGLGDWTPELLGPGQVLPVVSAPHPVLSRAGAQVDPTAEETVRLAADLVATMRVSPGCVGLAAPQVGVGAQVFAVDVTGHAKAVTVHGTFVLCNARVVEATRWKAGREGCMSVPDLTGDVKRASRLVVEGALPGSGEQVRLVTDGFEARALQHEIDHCAGLLFLDRVAGAHAIYQRKVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGY9</accession>
    <name>F4FGY9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42603">
        <property type="protein sequence ID" value="AEB42603"/>
        <property type="gene ID" value="VAB18032_07405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07405"/>
    <dbReference type="HOGENOM" id="CLU_2605095_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="8159" checksum="6AF321D8A47160F7" modified="2011-06-28" version="1">MAVTVAVFAGQQGGGVEQAGLLGLLVVVIGRLVTADPVLVTEIRTPAAPTLDLTHQGRPCAHAVPVDVAVPRPRRSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGZ3</accession>
    <name>F4FGZ3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42607">
        <property type="protein sequence ID" value="AEB42607"/>
        <property type="gene ID" value="VAB18032_07425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07425"/>
    <dbReference type="HOGENOM" id="CLU_3174543_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="47" mass="4935" checksum="C2B77D4A4826B133" modified="2011-06-28" version="1">MAHGPGPRWVIDPSLALPHTAALRVLGNGVVPEQAAAALRLLLHPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH46</accession>
    <name>F4FH46_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_07700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Vsr family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07700"/>
    <dbReference type="REBASE" id="34481">
        <property type="entry name" value="V.VmaORF7710P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42660">
        <property type="protein sequence ID" value="AEB42660"/>
        <property type="gene ID" value="VAB18032_07700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07700"/>
    <dbReference type="eggNOG" id="COG3727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111913_2_1_11"/>
    <dbReference type="OMA" id="HDCYLFK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="14700" checksum="7D3E8C3AE816CACE" modified="2011-06-28" version="1">MQGNRSRDTTPEVALRRALHARGLRYRVCAQPLPNLRRKIDVVFRTARVAVEVYGCFWHGCPQHHRQPTANNEYWREKITRNMDRDRRTCQALEDAGWLLIVVWEHEDVNLAAQRIVEAVRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH70</accession>
    <name>F4FH70_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732515.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13680"/>
    <dbReference type="EnsemblBacteria" id="AEB43848">
        <property type="protein sequence ID" value="AEB43848"/>
        <property type="gene ID" value="VAB18032_13680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13680"/>
    <dbReference type="eggNOG" id="COG1801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_0_1_11"/>
    <dbReference type="OMA" id="VLFNNCC"/>
    <dbReference type="OrthoDB" id="1068600at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="33789" checksum="89F8FEE2304A2BFA" modified="2011-06-28" version="1">MTVIKVGTSSWADRTLLRSGWYPREANTPAGRLSYYAGRFALVEVDTSYYAVPAPETTQGWVDATGDDFTFNVKAYRLFTGHPTPVATLPADLRPVGGPAQIRRRDLPPTAYDELWRRFRAALDPIAAADRLGAVLLQFPPWLARGDAARRRIAELADRCRPWRVAVELRHGSWFDGRAALETLAFLRDRGLTFCCVDMPQGHRESVPPILHATAELAMVRMHGHSTAWDSGDKEERFRYAYGDRELRIWSDLLTELAEQADELHVLFNNCCAGQAQRDAERLTELLAARRVPAGRSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH97</accession>
    <name>F4FH97_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732542.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43875">
        <property type="protein sequence ID" value="AEB43875"/>
        <property type="gene ID" value="VAB18032_13815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13815"/>
    <dbReference type="eggNOG" id="ENOG5031QCN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064711_1_0_11"/>
    <dbReference type="OMA" id="RERWLHH"/>
    <dbReference type="OrthoDB" id="2004116at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="27308" checksum="17092E5939AA8188" modified="2011-06-28" version="1">MEKTVLYQFLIDAPRAAAIWSVLLVLALGVLTALVARPEPVPPTDRTPDLPDHDDVADQRRYAGEVAVAAAGAAQNAGRRRAAWHRAQTELDRAWAAYDEAEAAARRLAAATAWPSPGTPRTPAEYAARERWLHHAAMAAYWRGDLTGRQLADALAHRAGWDPRRHPAEQEIFLARVVRDGRLAAYQAAAQQERDAWRAAELAADAARALSTEAYAAAQRLRPNPLPVPRRVVVGRPAATLRWRPARVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHL4</accession>
    <name>F4FHL4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26425"/>
    <dbReference type="EnsemblBacteria" id="AEB46383">
        <property type="protein sequence ID" value="AEB46383"/>
        <property type="gene ID" value="VAB18032_26425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26425"/>
    <dbReference type="eggNOG" id="ENOG50322A9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2479860_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046211">
        <property type="entry name" value="DUF6244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19757">
        <property type="entry name" value="DUF6244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="82" mass="8362" checksum="7B82FCDC9FD68959" modified="2011-06-28" version="1">MIVRLAAAAQKLDEAKAKTAAAAQDAAEARQLVAGALQGVAAGPLINMIDSYRQALAQAAQGGEPAKQHVQETIAKVRALGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHM5</accession>
    <name>F4FHM5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ordered locus">VAB18032_26586</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735045.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26586"/>
    <dbReference type="EnsemblBacteria" id="AEB46394">
        <property type="protein sequence ID" value="AEB46394"/>
        <property type="gene ID" value="VAB18032_26586"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26586"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_0_1_11"/>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="28277" checksum="7E9C9D0600A6EB70" modified="2011-06-28" version="1">MLDEILAGVREDVARRQEQVPLERIRELAAAAPPPLDAYAALRRPGVAVIAEVKRSSPSKGQLAEIADPAELAGEYAAGGARAISVLTEGRWFGGSLDDLASVRAAVNIPVLRKDFVVSSYQVHEARAHGADLVLLIVAALEQNVLVGLLERIESLGMTALVEVHDEEEADRALEAGAQVIGVNARDLRTLEVDRSVFERIAPGLPSSVVKIAESGVRGPHDLIRYASAGADAVLVGEGLVTKKSPREAVAELVNAGNHPATPRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHP3</accession>
    <name>F4FHP3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisH</name>
        <name evidence="11" type="ordered locus">VAB18032_26696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26696"/>
    <dbReference type="EnsemblBacteria" id="AEB46412">
        <property type="protein sequence ID" value="AEB46412"/>
        <property type="gene ID" value="VAB18032_26696"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26696"/>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_1_0_11"/>
    <dbReference type="OMA" id="WVYFVHS"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="13"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="22085" checksum="DE3F79033DBFBA00" modified="2011-06-28" version="1">MTDRDTPRPRVVVLDYGSGNLRSAERALAAAGADVTVTDDLVAAADADGLVVPGVGAFAACMAGIEALGAGPVIAGRVAAGRPVLGICVGMQILFESGDEHGVITKGLGLLPGNVTRLPAARLPHMGWNTVAPPVGSVLFAGLPADSRFYFVHSYAVCDPTALLAAGARVTTAHHDADFVAAVERGPLSAAQFHPEKSADTGATLLRNWLATVPTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI39</accession>
    <name>F4FI39_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_30199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
            <plasmid evidence="3 4">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30199"/>
    <dbReference type="EnsemblBacteria" id="AEB48003">
        <property type="protein sequence ID" value="AEB48003"/>
        <property type="gene ID" value="VAB18032_30199"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30199"/>
    <dbReference type="eggNOG" id="ENOG5031V7G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1467630_0_0_11"/>
    <dbReference type="OMA" id="AMYEQQV"/>
    <dbReference type="OrthoDB" id="370464at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB48003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="184" mass="19802" checksum="69FDEE54D4A1DAD6" modified="2011-06-28" version="1">MTPANGTDRSALVRAAQGKTAPTQRVPMGIRVVTGPGTSAASVPQPTKTVGRPVEKLLSVAAASESARTRQLAEKISGLLEELTGRVEAEEAQRREREAAEEQRRKLAEAEAALARQLAEVRQKLRTTGRDSAASPSRDRQSAEQRAAIRKWAVANGYDVKDRGRIPREVVQAWAAATGSEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI40</accession>
    <name>F4FI40_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECF subfamily RNA polymerase sigma-24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_30204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AB-18-032</strain>
            <plasmid evidence="8 9">pVMKU</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30204"/>
    <dbReference type="EnsemblBacteria" id="AEB48004">
        <property type="protein sequence ID" value="AEB48004"/>
        <property type="gene ID" value="VAB18032_30204"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30204"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_11"/>
    <dbReference type="OMA" id="DSARMMD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB48004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="180" mass="20257" checksum="CC1E93FDF69ABC78" modified="2011-06-28" version="1">MLVARAQAGDAEAFGEVYDRYVDQVFRFIYRRVLDRQVAEDLTSETFLRALRNLAAFRRPGGDFSAWVTTIARNLTINHLQSHQRRERPVAEVYEPVSTDVVASPETAAVERLTREALIVGIEKLSPMHRQCITLRYLRELSIEETAQALGKTPSAVKGLQHKALKALRGLLRGTVVMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F122</accession>
    <name>F4F122_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase sdr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731349.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07780"/>
    <dbReference type="EnsemblBacteria" id="AEB42676">
        <property type="protein sequence ID" value="AEB42676"/>
        <property type="gene ID" value="VAB18032_07780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07780"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_11"/>
    <dbReference type="OMA" id="IHNAGTA"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="301" mass="32064" checksum="48AD73EFC2CF3924" modified="2011-06-28" version="1">MTGWTADLIPDQRGRVAVVTGANSGLGLVTATELARHGAHVVLAVRNTTASEEAARRIGGDVEVRELDLASLSSVRAFAAKLAGDHPAIDLLVNNAGMVLLGPRRTSPDGFELHLATNMLGHFALTGLLLGNLAAAGEARVVSLSSITHKNAHLDFEDLMFERNYRAASAYGRSKLATTIFGIELDRRLRAAGAPIVSALAHPGLTRTNLTPRAWEHRGRFGRLIAWAGLPITQPVEQGALPQLRAATEPGVRGGQFFGPSRLWETRGRVTEARLSREAANPAAGRRLWAAAAELTGVSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F148</accession>
    <name>F4F148_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_07920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731375.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07920"/>
    <dbReference type="EnsemblBacteria" id="AEB42702">
        <property type="protein sequence ID" value="AEB42702"/>
        <property type="gene ID" value="VAB18032_07920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07920"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="OMA" id="RMGYKWN"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="122"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="122"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="23752" checksum="36876C8E34B85C4A" modified="2011-06-28" version="1">MLVVEDEDVLADAIAEWLRREAFAVDVAYDGDAALERLGVNTYEVVVLDRDLPVVHGDDVCRAIVDSGGETRVLMLTAAAAVRERVAGLALGADDYLVKPFALVELAARVHALTRRARPAAPPTLHRAGIVLDPGRREVYRDGRYVPLTRKEFAVLAELLRADGAVVSAEELLERAWDEHIDPFTNVVRVTVMKLRRKLGDPPVVETVPGVGYQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1B9</accession>
    <name>F4F1B9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_14215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14215"/>
    <dbReference type="EnsemblBacteria" id="AEB43955">
        <property type="protein sequence ID" value="AEB43955"/>
        <property type="gene ID" value="VAB18032_14215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14215"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_1_11"/>
    <dbReference type="OMA" id="CKQMEIT"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="41936" checksum="A9AFC802E41E26A9" modified="2011-06-28" version="1">MRHGDLADQRVGVFQAGGLSSLALGVWLREQGVASHHYVADLGQSDPDEIADLVASLRDAGLPASVVDLRPRMAEIGLDLLRYQARHDGGYWNTTGAARLVLVEQLTPVLRADGCTVLAHGCVGGGNDQRRFAAYAREFAPDLRVYAPWTDPDALERFAAGRGAMLNAVKDAGFFLDRGSDADRSTDACLAGASHESSALEDLATPVDAGSLTPRWSVYPSEAPAQAETVAVSFDAGRVTDVDGSGPDPVDVLRTARDLGARHGVWLRDVVERRIIGTRCRGVYEAPGLEILDTAWQRVLEVCLDPHARGLYQSLGPVLGAAVYEARYASPVAAAARAAIDELVRPATATVRLVLHRGTARVAGIDAPGVGHDQQTRFGTGGNRWREPIVGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1L2</accession>
    <name>F4F1L2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20705"/>
    <dbReference type="EnsemblBacteria" id="AEB45241">
        <property type="protein sequence ID" value="AEB45241"/>
        <property type="gene ID" value="VAB18032_20705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20705"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_0_11"/>
    <dbReference type="OMA" id="SHREICM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="234" mass="26040" checksum="4CE20B56194C5A5A" modified="2011-06-28" version="1">MGELVARQILEDIVEQGLSPGAALPTEAQMLQAYGVSRGTLREALRILEHNGLLRVRPGRGGGPIVGAVDPHTFGRTMALFMQMGRTRFGELVEARVIMEPLMARLAAERRDAARLRELAESMREHSTLEERDEASYLAVMQRFHGVVAGLSGNGVLDLFGRALKEIYTERVVAAERRPERWEDVRREHQAVAAAIADGDGAEAERLMRAHMLALADHLERDYAGLHDEVVGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1P3</accession>
    <name>F4F1P3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rv2175c_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735119.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26976"/>
    <dbReference type="EnsemblBacteria" id="AEB46468">
        <property type="protein sequence ID" value="AEB46468"/>
        <property type="gene ID" value="VAB18032_26976"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26976"/>
    <dbReference type="eggNOG" id="ENOG5032W34">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134416_1_0_11"/>
    <dbReference type="OMA" id="WLTLPDI"/>
    <dbReference type="OrthoDB" id="1752144at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041098">
        <property type="entry name" value="Rv2175c_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18367">
        <property type="entry name" value="Rv2175c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rv2175c_C" evidence="2">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="125" mass="13503" checksum="D68D32CEBE3201A0" modified="2011-06-28" version="1">MTDSVPTDNAAPGTTGPTDWLTLPDVAERLDLTISKVHQKIRDRELIAVRRDGVRRIPADLVANGTVLKHLPGVLNLLADAGYDDEAALRWLYEPDPTLPGGTPATALAGDQAREIKRRAQALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F206</accession>
    <name>F4F206_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736385.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03345"/>
    <dbReference type="EnsemblBacteria" id="AEB47753">
        <property type="protein sequence ID" value="AEB47753"/>
        <property type="gene ID" value="VAB18032_03345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03345"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_4_1_11"/>
    <dbReference type="OMA" id="VIREYHT"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="23158" checksum="1EC4CFD397B61F23" modified="2011-06-28" version="1">MTVDGRLARGERTRTAVLDAAVSLASENGLDGLSLGHLADSLGVSKSGIFAHWRSKQALQLATIDRAVAQWQELIITPALRAPRGVRRIWALHEARIDFYATRVLPGGCFFGTAEFEFNARPGAVHDRLATVLADWTAFLERLVREAVELGELPAEVDVALLAYEIDSFGIAAALRSRLFDPESTYRHARRSVLDRLRGLCPDPTLLPEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F279</accession>
    <name>F4F279_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42768">
        <property type="protein sequence ID" value="AEB42768"/>
        <property type="gene ID" value="VAB18032_08250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08250"/>
    <dbReference type="HOGENOM" id="CLU_142195_0_0_11"/>
    <dbReference type="OMA" id="YWQRPDP"/>
    <dbReference type="OrthoDB" id="2223852at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="11720" checksum="111083BF2F218D12" modified="2011-06-28" version="1">MTTSRPGPTSDEPWRRPETDDGAASGEPTPPRPTPGGGPVGYSGPPPTVAPPTGWRPPVHLQANPPRQLPPQDMIALDAQEQRAQRVTWGAGAVAGVVLVALVCLLCTRALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2M1</accession>
    <name>F4F2M1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733940.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20930"/>
    <dbReference type="EnsemblBacteria" id="AEB45286">
        <property type="protein sequence ID" value="AEB45286"/>
        <property type="gene ID" value="VAB18032_20930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20930"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_4_1_11"/>
    <dbReference type="OMA" id="AAYQMSQ"/>
    <dbReference type="OrthoDB" id="1135906at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="31803" checksum="ADB1E4BC3E7F0164" modified="2011-06-28" version="1">MSQDQHTQQDPTEQYGQQSGQPAQQQTPPGRTGEMNPKPDHGEETYSGSGKLDGKKAVITGGDSGIGRAVAIAFAREGADVLISYLSEEEDADAQDTVRLIEAAGRKGVAVRGDITDESTCQGLIDRALSDLGGIDILVNNAAYQMAQDKGIAGISTEQFDRVLKTNLYAMFWLCKAALPHLEEGSAIINTSSIQAFDPSPQLLDYATTKAGIANFTKSLAADLVDKGIRVNAVAPGPIWTPLIPATMPEKKVEQFGTDTPVGRPGQPAELAPAYVFFASQESSFITGEVLGVTGGRFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2S3</accession>
    <name>F4F2S3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21190"/>
    <dbReference type="EnsemblBacteria" id="AEB45338">
        <property type="protein sequence ID" value="AEB45338"/>
        <property type="gene ID" value="VAB18032_21190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21190"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_2_2_11"/>
    <dbReference type="OMA" id="HGPIPEV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="215" mass="21059" checksum="89C2169505EC7805" modified="2011-06-28" version="1">MVTMTDLLTAELTAQRLLAIIRGTDTAAAIATGTALLAEGVSIIEVALTTPGALDAIAAIRADAPAGTLVGAGTVLTPAAVADVAAAGAQFVVTPAVVDSIPEAVRRGLPVAAGALTPTEAYTAVRWGASVVKLFPASVGGTAYLKAVRDPFPDIPFVAVGGVGLAELPGYLAVGAIAVGVGGPLVGDAASGGDLDALRGRARAYRAAVREAGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2U2</accession>
    <name>F4F2U2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low temperature requirement a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735203.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27401"/>
    <dbReference type="EnsemblBacteria" id="AEB46553">
        <property type="protein sequence ID" value="AEB46553"/>
        <property type="gene ID" value="VAB18032_27401"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27401"/>
    <dbReference type="eggNOG" id="COG4292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045667_2_0_11"/>
    <dbReference type="OMA" id="NMLFQLR"/>
    <dbReference type="OrthoDB" id="886435at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="PTHR36840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="443" mass="48123" checksum="CD3E94DECCB26863" modified="2011-06-28" version="1">MSEKGWRGRLGPAVGVAPGARVDKFEIFFDLVFVFSFFNIARTTATEITGRSLFHALLVLSVLWWCWVVHTVVATRVRIGEGFVPVLMVAGMAALFSFALALPQAFQDSQGTHAGPVVVAISYVVIRAVHLALFLHIVRDNPTERRQLMRYAPELTLSTVLLLVSALLPGKLTDTGTAEVIRDGLWVSVILLQYGTGLLASTWGWEVTSAEHWTERYDLILIIALGESVISVGLGSNLIGQPPTWPGVTAAVLGIVFTAALWWVHYDVIGPAARIALHATLGRPRVLMARDAYAYLYLPMIAGIILFALGAEGIVHDIAEPGVPFSEPAHGPDVPLLFGGVIFYLAGNMLFQLRTLHTLSWLRLGTLGVLAACIPVAMVLPGLVTMGLLTAICVGLITAEVVLMSEGRRALRAAVYEERTAHEAHEAAYRARWHEDPPDTMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Z9</accession>
    <name>F4F2Z9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735260.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27686"/>
    <dbReference type="EnsemblBacteria" id="AEB46610">
        <property type="protein sequence ID" value="AEB46610"/>
        <property type="gene ID" value="VAB18032_27686"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27686"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_5_11"/>
    <dbReference type="OMA" id="AGWMREN"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="265" mass="29048" checksum="7C9CB72D0B7B313D" modified="2011-06-28" version="1">MSYAQINGVRFWYETHGAGRPLVLLHGGFGAVETFAAVRPALTRRRRVISVDLPGHGRTADVDRPLRYESMADDIAALIVELGLAPTDVLGFSLGGGVALRLAIQHRELVRRLVVVSAPCRRQGWFPEVLAGMPDPDEAAGDQLRGTPPYQLYQAVAPRPQDWSRLWVKTGELLRREYDWSPEVATLTTPTLLVFADADSVRPDHMVEFFGLLGGGHRDAGWDGTDRPDARLAVLPGLTHYDIVDSPALPAAVLPFLTHTLHTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3D0</accession>
    <name>F4F3D0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08680"/>
    <dbReference type="EnsemblBacteria" id="AEB42854">
        <property type="protein sequence ID" value="AEB42854"/>
        <property type="gene ID" value="VAB18032_08680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08680"/>
    <dbReference type="eggNOG" id="ENOG502ZBFQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965182_0_0_11"/>
    <dbReference type="OMA" id="GGHDTWD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="312" mass="34068" checksum="830538D77B1F1424" modified="2011-06-28" version="1">MARQSPQRPDADEPELDDTTGPTEPDATDESEAVADADPGASRALWEELRIDPVEIALPAGTGYTLRAYRPASELTPTDVAERDADDPFLARRQVVEAEDDEDGDVVILDEEIAREFAESDDEEKRSKDGDTDAKGDKDDTDEKAAEEAGDEEVPIFLSHRGRLLLFKTPEALVSFVRSGAPNDLSQLDSWNELSERVEPADIAPLDEDIYELDLVVENLRGGHDTWDPTLLIEAGEVARDLSYALRLPAVLDMLSAGSSLDDLDEALRASVNGGIGGFLGRRRLKKIGAQTASLGWRTIVGKISAVVDWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Q9</accession>
    <name>F4F3Q9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734014.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21300"/>
    <dbReference type="EnsemblBacteria" id="AEB45360">
        <property type="protein sequence ID" value="AEB45360"/>
        <property type="gene ID" value="VAB18032_21300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21300"/>
    <dbReference type="eggNOG" id="ENOG5034296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1474337_0_0_11"/>
    <dbReference type="OMA" id="WSHRRIL"/>
    <dbReference type="OrthoDB" id="1775986at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="184" mass="20363" checksum="614669C90D8B7A44" modified="2011-06-28" version="1">MLVGDGGYQRWAAFLEQWRAGSANDPQGLPTLVEQDYPAEVWLRLVTRLTDALAYRLQTWADALIDAMAATRDEFEMARALTQARRGLAAIRAVAAHPALPGKLARALRDQVDEQIRLVQRALEDGIDDARRAGLDDRLVQARLRTLRDNPLTVQDRSPAGTGWAAAPARPGRRIIVDPPVRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3U0</accession>
    <name>F4F3U0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine (Or cysteine) proteinase inhibitor, clade B (Ovalbumin), member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21455"/>
    <dbReference type="MEROPS" id="I04.073"/>
    <dbReference type="EnsemblBacteria" id="AEB45391">
        <property type="protein sequence ID" value="AEB45391"/>
        <property type="gene ID" value="VAB18032_21455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21455"/>
    <dbReference type="eggNOG" id="COG4826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023330_0_2_11"/>
    <dbReference type="OMA" id="KDVWRGL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000266">
        <property type="term" value="P:regulation of blood coagulation, intrinsic pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015555">
        <property type="entry name" value="AT-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="PTHR11461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF53">
        <property type="entry name" value="PTHR11461:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="SSF56574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERPIN" evidence="2">
        <location>
            <begin position="49"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="44188" checksum="2EF8BAAC6EA86ED1" modified="2011-06-28" version="1">MPLAAAALTATPGQLRRLDESSTSTDPIRVPPDPATLAAAATAVRGFSADLYRELASTRPGDNVVCAPYSVGLALAMTRAGAGSATAAEMDAVLHAPHPRPGALDSGLNTIEQTLATRYQDGDGTARPLLRTANALWTRLGLGLRPGFQDTLAGYYGAAPHPVDFAGAPEAARQEINTWVSDRTNAKIPELLPIGAVSPGTKLILTNTTYLKAAWRYQFLPALTATESFTRDDGSVVGVPMMRGPFAGMGYQVGDGWRAVDVPFAGDRLGMAIVMPTGDDLAAIEANLDGAWLSALLTGFGGATVQLRLPRWTFRLPAQLAVALSNLGMPTAFTPQADLSGMSTDSALYIDDVLHETFIAVDEKGTEAAAASAVIIPPPSIPQGPQFFVNRPFLYVIHDWYTGVPLFLGRVHDPLVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F480</accession>
    <name>F4F480_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding region atpase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04055"/>
    <dbReference type="EnsemblBacteria" id="AEB47893">
        <property type="protein sequence ID" value="AEB47893"/>
        <property type="gene ID" value="VAB18032_04055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04055"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_5_1_11"/>
    <dbReference type="OMA" id="ACKHGRP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="137" mass="14261" checksum="7AD29F9F83C5EC79" modified="2011-06-28" version="1">MVVPHHATGARVARHRLATELAEVVPPTVLADLVAVLAELVGNAVRHADPLPGGVVRVSWRLRATTEGTQVRLQVTDGGAACGPQIRPADLGAADGRGLHIVSGLADRWGVERDGLGQSVWADFDPVPQRPGLVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4H0</accession>
    <name>F4F4H0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731599.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42928">
        <property type="protein sequence ID" value="AEB42928"/>
        <property type="gene ID" value="VAB18032_09050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09050"/>
    <dbReference type="eggNOG" id="ENOG50333DA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076067_0_0_11"/>
    <dbReference type="OMA" id="DIRITYA"/>
    <dbReference type="OrthoDB" id="1597959at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307409" evidence="2">
        <location>
            <begin position="24"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="28681" checksum="37D7070536FA777E" modified="2011-06-28" version="1">MTVRRLSAGLMAAALLTPGVAACTGDSTAGPTGTPSATASATASGAAGDAEAKQALLDSTREISNGNFRFRMSGVGSTAEGQVHQPSQSAQMRVNIGEPTDDLAMTLDLIHAKPDSWVKLDLQGAAASSVPGRDKLSLGKYQHLDQTRIQGNRNLGFDFEKVDPAGSAVLTQAVTEVRRTGDGAYAGTIDLSKAAEAGSLDQSMITALGAQANSVPFTATTDAQGRLTELILQVPGTGETAAQEIRVTYSDYGNATAAQKPPADQVVEAPPELYNLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4N3</accession>
    <name>F4F4N3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732840.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15315"/>
    <dbReference type="EnsemblBacteria" id="AEB44175">
        <property type="protein sequence ID" value="AEB44175"/>
        <property type="gene ID" value="VAB18032_15315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15315"/>
    <dbReference type="eggNOG" id="ENOG5030TBU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2233418_0_0_11"/>
    <dbReference type="OMA" id="RWYARLI"/>
    <dbReference type="OrthoDB" id="2061230at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="102" mass="11266" checksum="4FF997DC30D76CFF" modified="2011-06-28" version="1">MRAGELLGRTAYDEQGRRLGRVVDLVVRGTPGGPLRLTDLVVTRHWYGRLSGRLIGPERHPSGPWAIRAAARLLGRSTVQVPVHRLRLDPPVPGLPEDPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F506</accession>
    <name>F4F506_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21975"/>
    <dbReference type="EnsemblBacteria" id="AEB45495">
        <property type="protein sequence ID" value="AEB45495"/>
        <property type="gene ID" value="VAB18032_21975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21975"/>
    <dbReference type="eggNOG" id="ENOG5033YYY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151275_0_0_11"/>
    <dbReference type="OMA" id="WFRWSDE"/>
    <dbReference type="OrthoDB" id="1827290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="107" mass="12573" checksum="A0497D33983D813F" modified="2011-06-28" version="1">MWTLHRRDDGGLLAELVVTGGDFPWLNAHVRPTEGFPEVRPLFAEELRLLDHIDQNGESWERAYDAVRNAVTLRYPQGREVPEFLLHIEGDEAWWRWSDEPFDKEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F588</accession>
    <name>F4F588_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735419.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28496"/>
    <dbReference type="EnsemblBacteria" id="AEB46770">
        <property type="protein sequence ID" value="AEB46770"/>
        <property type="gene ID" value="VAB18032_28496"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28496"/>
    <dbReference type="eggNOG" id="ENOG5031AT3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104624_2_0_11"/>
    <dbReference type="OMA" id="NDVWLHA"/>
    <dbReference type="OrthoDB" id="2066547at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025492">
        <property type="entry name" value="DUF4383"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14325">
        <property type="entry name" value="DUF4383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="158" mass="16597" checksum="E863531F19BB5FAA" modified="2011-06-28" version="1">MAHHARRGRPGRSRVQLAALAVAALFLVLGVAGFIPGITTGYGDMTFAGHHSGAKLLGLFQVSILHNLLHLGFGLIGLLLARRLAGARIFLTAGGAVYLALWLYGWATEDDSSANFIPVNSADDFLHLGLGFGMLALGLLLSNNVGTGGRLDDPLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F4F589</accession>
    <name>F4F589_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTPase Obg</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">obgE</name>
        <name evidence="7" type="synonym">obg</name>
        <name evidence="11" type="ordered locus">VAB18032_28501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735420.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28501"/>
    <dbReference type="EnsemblBacteria" id="AEB46771">
        <property type="protein sequence ID" value="AEB46771"/>
        <property type="gene ID" value="VAB18032_28501"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28501"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_1_11"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="G_OBG"/>
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    <dbReference type="InterPro" id="IPR006073">
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        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
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        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
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        <property type="entry name" value="GTP1-OBG_CS"/>
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        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
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        <property type="entry name" value="OCT_dom"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP1OBG"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OBG"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="160"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="348"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="494" mass="52369" checksum="AB4122F798FECA88" modified="2011-06-28" version="1">MTMFVDRVVLHLQAGDGGHGCVSIHREKFKPFGGPDGGNGGHGGSVSLVVDPQVHTLLDFHFRPHIKAQNGRGGAGSNRDGANGADLVLTVPDGTVVQTMDGTVLADMVGAGTTFEVARGGRGGRGNASLANARRKAPGFAELGEPGEHLDVVLELKSVADVGLVGFPSAGKSSLISVISAAKPKIADYPFTTLVPNLGVVRVDNHTFTVADVPGLIPGAATGKGLGLEFLRHIERCAVLVHVIDTATLEPGRDPLADIDTIEAELAEYGGLADRPRLVALNKIDVPDGRDLADIVRPDLEARGLRVYEVSAATREGLKELTYAMAELVEQSRAAAPPAEPTRIVLRPKAVDDAGFTIEAEPDGSYTVRGVRPERWVRQTNFDNDEAVGYLADRLARLGVEDQLARAGAQPGDLVRIGEREFDWQPTLYAGAEFTPGTRGRDIRLEEKSTRASAAERLAARKARRQRPADEVEAAPEATAAIEARAAIEADDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Q9</accession>
    <name>F4F5Q9_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Appr-1-p processing domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">VAB18032_15810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15810"/>
    <dbReference type="EnsemblBacteria" id="AEB44272">
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    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15810"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
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        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="277" mass="30189" checksum="394B3DB695A65A96" modified="2011-06-28" version="1">MDAIVNAANKAMRGGGGVDGAIHRGGGPAVLRDCIARFPEGLATGDAGWTTAGDLPARWVIHTVGPNYHAGERDRSLLESCYRRALEVADELGARSVAFPLINTGVRGWPHADAIAAAIETIAAAETGVDEVRLVAFDEAMHKRTRAAVWVRCPPPVDTDSVGSLFEREPIQYSLRGDFYLWYELRARFADTPLPHDCYDLRMLIMDTIEQIVGKHPASLESAPWHDPTGAIYVPEFDPGHGMSAGAVHVPWWVHTGLPILLDRYAARRESSAFTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5S1</accession>
    <name>F4F5S1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732948.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15870"/>
    <dbReference type="EnsemblBacteria" id="AEB44284">
        <property type="protein sequence ID" value="AEB44284"/>
        <property type="gene ID" value="VAB18032_15870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15870"/>
    <dbReference type="eggNOG" id="ENOG5031SD2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604015_0_0_11"/>
    <dbReference type="OMA" id="PGDRKVM"/>
    <dbReference type="OrthoDB" id="14766at28056"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="453" mass="46373" checksum="C38418045685110B" modified="2011-06-28" version="1">MEGLSLTPATQAVFDALTELGQGNVHELADKAGKARSTTDKAIKTLADAGLIAAVDTHADPAEGALTRWTLATSVEAADAVPDDATDLGGEHPVNPDETVPLNGIDPDNAADQPDIGDTEQADQTGNEADGDEAADEEPDDTADETDRDDADSDADDADSDADDADSDADDADSDADDADSDADDADSDADDADSDADDAGRTVAVVQPTRPGDRKVMAIKGVLADYGDDGATLALIVAESGIGHVTATRLLTAMEQADAARRLPGEPLRWIPGPTRASEVDPNPEPPRCPLCCQVIRGLANAPSATAAVLPLIRPDGTLHIVGPDGETHIVALSTRTAPRAAATTRSVARSGDGTVNADGNQPFGRGELERLTLDYLAASPGRQMTPQDIATALAAQLNRAVSNGAVRNNLTKAAAAGRILLVSDNPLTFVHPAPTDSGAAAEADPGSTEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5U8</accession>
    <name>F4F5U8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45507">
        <property type="protein sequence ID" value="AEB45507"/>
        <property type="gene ID" value="VAB18032_22035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22035"/>
    <dbReference type="HOGENOM" id="CLU_3334357_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025335">
        <property type="entry name" value="DUF4241"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14025">
        <property type="entry name" value="DUF4241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="38" mass="4116" checksum="082CB9DA88E24B13" modified="2011-06-28" version="1">MYVVGSSWGDGVYATYIGRTAEGDIASFVTDFRVVPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5X5</accession>
    <name>F4F5X5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SyrP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_22170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734187.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22170"/>
    <dbReference type="EnsemblBacteria" id="AEB45534">
        <property type="protein sequence ID" value="AEB45534"/>
        <property type="gene ID" value="VAB18032_22170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22170"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044153_0_0_11"/>
    <dbReference type="OMA" id="HMIANNT"/>
    <dbReference type="OrthoDB" id="1742732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="315" mass="34565" checksum="D0EA5DF56113C430" modified="2011-06-28" version="1">MTAVASGGRVVEPWPVRADADDWLYDNRVELRQRLTETGVVHLRGLGLDAPERFASAVEALVRPCPRREPFAPRPHLGGPVYGPPAWPSYRDMCPHNEQSHALVFPGTLLLAHPPGAATSGRTLLADGVEALSRLPSRVRDAFVTRGWMLVRNFRPYVGMGWRQAFGVETVAEVEAYCAGQSIGYEWLPDGTLRTRQARASTFVHPVTGATAWFNQIAFLSEWSLQPEEREVLVGAYGRTGLPFNTFFGDGEPVPAEDLAAVQEAIDASTFDLSWTPGDLVLVDNVRMGHGRSAHDGTWPLWEAQGDPIPAVDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Z2</accession>
    <name>F4F5Z2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_22255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734204.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22255"/>
    <dbReference type="EnsemblBacteria" id="AEB45551">
        <property type="protein sequence ID" value="AEB45551"/>
        <property type="gene ID" value="VAB18032_22255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22255"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_4_11"/>
    <dbReference type="OMA" id="TWVHRFW"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="8"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="193"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="386"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="552" mass="57679" checksum="589FE33A8771057F" modified="2011-06-28" version="1">MTDHAGTTAAARLVATLRAHGVDRVFCVPGESFLPVLDGLADAGIDLVTCRHEGGAAFMALADAKLTGTPGVVLVNRGPGATNAAIAVHSADLDATGLLLIVGDVPTVERGRRSFQELDHQGTFAGMSRGVFTVGHPHHVAEFTARALAAARGGVPGPAVLVVPEDVLTAPVPTIVSGAPVATEVAPAPADAIDRALALLSGSRRPVLVAGSQVDAPQGRRALKEAAHRHRLPVLVTNKRQDLFDNTDPLYAGHLHLATPAHQRDLVGRADLVLAVGTRLDAVSTQRYTLPDPGTALVHVYPDATVPGGAYRPRLAYACSPIAFLEQLAAAPPRAIVDDDWVRQLADHEAEQARWAPVTAGDGVVFGRVVAVLSDLTSGRGVVTIDAGNFTSWVHRYHRVVEEGRLLGIGSSAMGFGVPAGVAAALRHPEQPTVVFVGDGGFLMTGSELATAVQRHARVVIVVADNGSYGTIRQHQERRCPGRVVGTDLTNPDFALLAHAYGALGLTIGTDAEVEPVLSKALAHPGPVVVHVRTSLTHISAYQRLTAPGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F656</accession>
    <name>F4F656_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46808">
        <property type="protein sequence ID" value="AEB46808"/>
        <property type="gene ID" value="VAB18032_28686"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28686"/>
    <dbReference type="HOGENOM" id="CLU_3349990_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="37" mass="4318" checksum="CF4941FD185F39A3" modified="2011-06-28" version="1">MRARDAARPTDEDLAAAEAEIVIVRRNWTPRDELPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6F3</accession>
    <name>F4F6F3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731770.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09905"/>
    <dbReference type="EnsemblBacteria" id="AEB43099">
        <property type="protein sequence ID" value="AEB43099"/>
        <property type="gene ID" value="VAB18032_09905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09905"/>
    <dbReference type="eggNOG" id="ENOG502Z8CB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041026_0_0_11"/>
    <dbReference type="OMA" id="WTLLDHP"/>
    <dbReference type="OrthoDB" id="1271858at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="397" mass="41448" checksum="61AD1D8CC5C6C4BD" modified="2011-06-28" version="1">MTSSEQRLAKIRGGLPPRRHNARTIAALTGNPGCTRRAVLDGAGVDKPSLAERVGFPARFGQSRFAITRGNTFEAQVKADGGAELLRLVAERLGVPVPAVATWTDLGDGDELAGRVERSAALLTDAVTPHEPTEPDGAADPRQAASPGHAGSPGHAGSPDLVDQGAALFDHPLLGLEVAGRRVHLEPDLVAARLGGRFHVVEIKSFPVVDGQADAAKLAAAAVQSAVYVLALRELLATRGLDPDLVSHEVVLICPRDFTNQPVAHLLDVRKQLLVVRRQLDRMAQLDELLAGVPADFTADPAADPATLVASLSQVPARYAPDCLASCELAYFCRQEAGGQTAALGRPVREALGGIDRVAEVLALAAGEPVADPQRAEAAALLRTAARLRAEALSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6J6</accession>
    <name>F4F6J6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732984.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44324">
        <property type="protein sequence ID" value="AEB44324"/>
        <property type="gene ID" value="VAB18032_16090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16090"/>
    <dbReference type="eggNOG" id="ENOG5032ISH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2621063_0_0_11"/>
    <dbReference type="OMA" id="WGGGEFC"/>
    <dbReference type="OrthoDB" id="2155446at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="78" mass="8464" checksum="FBB0819375B780D0" modified="2011-06-28" version="1">MPHDPLQDMPAESRAELTAAVCAAIDIDQATAEDIIRSTEPFLDAMERAGGLVDSWGGGEFCYVLPRLLSFIRQTANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6W7</accession>
    <name>F4F6W7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22710"/>
    <dbReference type="EnsemblBacteria" id="AEB45642">
        <property type="protein sequence ID" value="AEB45642"/>
        <property type="gene ID" value="VAB18032_22710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22710"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014914_0_0_11"/>
    <dbReference type="OMA" id="GWRTMPY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="228"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="869" mass="94735" checksum="0EAED79E238B4236" modified="2011-06-28" version="1">MVTVDDRYDSYCAADRHFYDSLGNATAEPTFAAARRPLPDGWRTEPLDDWLIYAPDGGSLPQQGWKIHVSATLDNAERVLDAIWDYCVPRGLSFKFLRGPRTLLLRNSKYASRAASGKFVTVYPHDDAELELVCKELDELLAGESGPYILSDLRYGSGPVYVRYGGFAARYCHSADGQVVPAIEDDNGALVPDRRDPVFHVPSWVTLPDFLAPHLAARNATSTDEVPYRIEKVIHFSNGGGLYIGRDLRTDTQVVLKEARPYAGLDADGTDAVARLSREAAALRRLADLPQVPRVHDEFTLGEHRFLALEFIEGRALNKVLVDRYPLIDADATDTDRAAYTRWALDIHRQVEEVVRAIHERGLVYGDLHLFNVMVRPDDRIALVDFEVAAPIDGHRRPGLRNQGFAAPRDRSGPAVDHYALACLRLALFLPLTQLFRLAPAKTAHLADVIAARFPVPGALLDAAVEEITGESPAAAEHRADLTVDVGPSHRDRLARAILASATPERDDRLFPGDIEQFRSGGLNLAHGAAGVLYALHVSGAGRQPEHERWLVRQATSPASGTRCGFYDGLHGVAYALELLDRRQDALDVLDICLRQPWDGLDHSLAGGLSGIALNLAELAGRTGETTLRDAAWRAADRVIAQLADAPESDVSGGRHPYAGLLRGRTGPALMLIRLYELTGDPQLLEHAATALRQDLHRCVVRPDGALEVNEGWRTMPYLGQGSVGIGLVLDQYLRHRADERLAEASAGVRRAARSPFYAQSGLFAGRAGIVAYLAAYPDDPQLATELAAQVERLAWHALPYADGIAFPGEQLLRLSMDLGTGTAGVLLALAAARPDTAVTLPFLAPLTGATDTLADARGTDQPDKHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Y2</accession>
    <name>F4F6Y2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dtdp-4-dehydrorhamnose 3,5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734309.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22785"/>
    <dbReference type="EnsemblBacteria" id="AEB45657">
        <property type="protein sequence ID" value="AEB45657"/>
        <property type="gene ID" value="VAB18032_22785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22785"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_0_0_11"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="OrthoDB" id="1618609at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="22352" checksum="DBF0E86BFFB2B2CC" modified="2011-06-28" version="1">MKLRQLGIEGAWEITPQQHGDSRGLFLEWYRFDRLAEEVGHPLRLAQGNLSVSARHVVRGIHFADVPPGQAKYVTCVRGAVLDVVVDLRVGSPTFGEWESVRLDDVDRRAVYLAEGLGHGFCALTDDATLSYLCSTTYNPTAEHAVHPLDEELGIEWPTGTPLLSARDAAAPNLAQVRAAGLLPEYETCRRYAAELDAEAPDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F827</accession>
    <name>F4F827_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735650.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29656"/>
    <dbReference type="EnsemblBacteria" id="AEB47002">
        <property type="protein sequence ID" value="AEB47002"/>
        <property type="gene ID" value="VAB18032_29656"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29656"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540671_0_0_11"/>
    <dbReference type="OMA" id="YLSFHGY"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="385"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="516" mass="55508" checksum="F59D30694A2F2374" modified="2011-06-28" version="1">MGWLDRVDDQVDALKKARALQEVSRSTEAYAILEQVLRTTSAPHARADALVQRLSALINLGRTAEYTRAIEEASAAVRDLAEPYLHGHLNALAALAAHHQGALDRCVTHLVRSARALGAVDDPDRDTAWGWHDLAMAYSYLSFHGYALGAIERARQLGNAAGIPEETFAAPGIRLRNAVALDHTGDGDGCLRVLRDIATDLDRFIATGTADRLRPSSLAAYGYAGARRAALGDVVETVRGADPARLLGHGADSARARDMRQLGQVCLAIADGRPIEAVTRLGSVQVSAETLGAAEPARLRSIALGRAGDHAGAHRADRLAFRLAAQRHDRLRDVYIDGIAARIDHEEMRREAARFEGEALTDPLTGLPNRRRLERYIAAVVARGERVVIGVCDLDGFKAVNTRHGHHSGDLVLQRIAGVINRVMRRGDFVARYGGDEFVVVLPGAGMTEAAEVARRIDAAIRTEDWESLVPGTPVGVSIGFSEVAPGGPGQRDALGAAFEAADREMLRAKDRPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8D9</accession>
    <name>F4F8D9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733141.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16900"/>
    <dbReference type="EnsemblBacteria" id="AEB44484">
        <property type="protein sequence ID" value="AEB44484"/>
        <property type="gene ID" value="VAB18032_16900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16900"/>
    <dbReference type="eggNOG" id="ENOG5033HNC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121327_0_0_11"/>
    <dbReference type="OrthoDB" id="1702903at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12530" checksum="D9D3D5808F29B8B0" modified="2011-06-28" version="1">MEALVALSMGDSGVRSVGVGDYINLFFDVIDDDIPWQWRDWSCFTPEEVERLDAVHGLLQAACVVTPWNDTDDDFIASGWPGRIQPAARAALDVMQARGRFREDAEEENPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8F8</accession>
    <name>F4F8F8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44503">
        <property type="protein sequence ID" value="AEB44503"/>
        <property type="gene ID" value="VAB18032_16995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16995"/>
    <dbReference type="eggNOG" id="ENOG503440B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1546779_0_0_11"/>
    <dbReference type="OMA" id="EFREQFW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="183" mass="21215" checksum="BDD3A03CA50FEBD2" modified="2011-06-28" version="1">MATYPARHGLSYDCAGGLMTRRFGDRATFAVEVGRVGSHQLRVVDLWAAGKRLTTEDNWAFLPFFIRVMRSSAAQVRRRDVKPCPFPGRAPEEIFRLLHADETEFREQFWFMRWGETVDNVSMYGYLDDDLVIVFEFWRDDHPFAEDLSKVFIARIPPEEFVATVEEAAHLLDAELANVDPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Q2</accession>
    <name>F4F8Q2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-carnitine dehydratase/bile acid-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23485"/>
    <dbReference type="EnsemblBacteria" id="AEB45795">
        <property type="protein sequence ID" value="AEB45795"/>
        <property type="gene ID" value="VAB18032_23485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23485"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_5_0_11"/>
    <dbReference type="OMA" id="NYIGYAG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="391" mass="41477" checksum="D63A815DB622D4D9" modified="2011-06-28" version="1">MTEMTAELPTGPLTGVRVIELAGIGPGPFAAMMLADLGADVIRVDRVGDVDPSGFGTPHPDLLNRGRRSIAVDLRSTDGREVALALIGDADALIEGFRPGVTERLGLGPADCHAVNPRLVYGRMTGWGQDGPYAPYAGHDITYLALTGVLHGIGRAAEPPVPPLNLLGDFGGGGMMLALGVVAALYAVRGGAAGQVVDAAIVDGVAVLSTQIHALRRLGMWQDPRGVNLLDGGAPFYDSYECADGRYIAVGALEPKFYDELVRRTGFPLPPDEAPDRTDPANWPALRAAWARLFRTRPRDEWAALLAASDSCLAPVLDWQEAPEHPQLAARRTFVVHDGVRQPAPAPRFSGSPTAVRRPPPWPGEHTDEVLDEIGYPADRVAQLRAAGTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Y9</accession>
    <name>F4F8Y9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.101</ecNumber>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_29991</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="10"/>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29991"/>
    <dbReference type="ESTHER" id="verma-f4f8y9">
        <property type="family name" value="Chlorophyllase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47069">
        <property type="protein sequence ID" value="AEB47069"/>
        <property type="gene ID" value="VAB18032_29991"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29991"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050214_0_0_11"/>
    <dbReference type="OMA" id="PWPKAML"/>
    <dbReference type="BRENDA" id="3.1.1.14">
        <property type="organism ID" value="16319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="313" mass="31915" checksum="0DE8CA385247E410" modified="2011-06-28" version="1">MGCSADPESAPLAGTTATSATDTPTATAAPSASASAPAIPAGNAPADSFAVGVRQLKRNRDGDRPLPITVWYPAAGRAGGKPTESARAADGRFPVVMFSHGLGGQPKDYQALLTRWAAAGFVVAAPMFPHTSGSGQPNVLDVLNQPADVSYALSQVLALDARDGDVLRGRLATDRVAAAGHSAGGVTTIGLFTTGRDERLAAGIVFAGTALGVGTAFAGAAAPQLFVHGEADEVVEYAAGKAVYDKVPWPKAMLSLPNGDHGRALLGNSTSLRVVADTTTEFLRWTLYGDAGAKERIASAAARDDVATLDNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Z1</accession>
    <name>F4F8Z1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_30001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30001"/>
    <dbReference type="EnsemblBacteria" id="AEB47071">
        <property type="protein sequence ID" value="AEB47071"/>
        <property type="gene ID" value="VAB18032_30001"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30001"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_11"/>
    <dbReference type="OMA" id="HKYAAVV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="158"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="387" mass="39604" checksum="7BC6229C483B2772" modified="2011-06-28" version="1">MDPADPVFQLHRGGKMAVVSTVPLTSRDDLSLAYTPGVARVCEAIAAEPALAHDYTWASNTVAVVTDGTAVLGLGDIGPRAALPVMEGKAVLFKQFGGVDAVPVCLDTQDVDEIVAVVKALAPSFGGINLEDISAPRCFEVERRLDEALDIPVFHDDQHGTAIVVLAALRNAATLLDRKLGDLRVAVSGAGAAGVAVTKMLVAGGVDPDQVVVCDSKGIISAYRTGLTGTKAELAELTNADGRQGDIAEALRDADVLIGVSGGQIPEHAVAGMAPGGIVFALANPTPEVHPEVAARHVAVVATGRSDFPNQINNVLAFPGVFRGALSARATRITDAMKVAAADAIASVVAEALTPEAIVPSPLDPRVAPAVAEAVAEAARRDGVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F924</accession>
    <name>F4F924_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730726.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04630"/>
    <dbReference type="EnsemblBacteria" id="AEB42052">
        <property type="protein sequence ID" value="AEB42052"/>
        <property type="gene ID" value="VAB18032_04630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04630"/>
    <dbReference type="eggNOG" id="ENOG5031V3S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2844941_0_0_11"/>
    <dbReference type="OrthoDB" id="2219477at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="7369" checksum="6E6F4B108FA3D3E0" modified="2011-06-28" version="1">MLTFVATSILYVCGFIFLYGVIRLAVRHALEDVEMRRVQAQRAEEMAAARDRALLQKHGFLSNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F935</accession>
    <name>F4F935_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-D-S-L family lipolytic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04685"/>
    <dbReference type="EnsemblBacteria" id="AEB42063">
        <property type="protein sequence ID" value="AEB42063"/>
        <property type="gene ID" value="VAB18032_04685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04685"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069365_1_0_11"/>
    <dbReference type="OMA" id="FVGWADR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="28382" checksum="11B361253A5D2A8C" modified="2011-06-28" version="1">MVRWRSYVAVGDSFTEGLDDPYPDGSFRGWADLVATRLAAEAGPDFQYANLAIRGRTFPNVVAEQVPMALAMKPDLISFAAGGNDVLRRTFDPDALAARFDQVVGRLRADGADVVLFRFADVTPRLPGQRLIGPRLAVVNRAVGETAERHGAILVDLYADDTYLNSTLWSTDRLHLSAAGHRRVAGQVLAALGVGCDEQWLLVPPHPEPTPWLSARAADLRWAGQHLAPWIKRRITGRSSGDTLTAKRPLLGPLPPQPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F940</accession>
    <name>F4F940_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04710"/>
    <dbReference type="EnsemblBacteria" id="AEB42068">
        <property type="protein sequence ID" value="AEB42068"/>
        <property type="gene ID" value="VAB18032_04710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04710"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_3_2_11"/>
    <dbReference type="OMA" id="FHNTRGT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="312" mass="33131" checksum="A1AE1C3BEBF2797D" modified="2011-06-28" version="1">MHSEVAGMRELPGVVSIREVGPRDGLQNEEPIPTEAKVRLLDALSRTGVRRIEAVSFVHPKAIPQMADADEVWQRATKVDGVRYSALVPNTRGAQRALAAGFTEIEVVVSASDTHNRRNVNRSTAESLDDIAELIDMLHGAGAQAEVIIATSFGCPYEGDIDPTRVAAIVERVVADGADRVAFGDTTGMGTPRRVRDLLTAVRDRNADIPVLLHFHNTRGTALANLLTALEFGVTEFDASVGGLGGCPYAPGASGNLATEEAVHMLHDMGIDTGIDLDALIDAAKLAEDLTARRLPSGVLRAGPRTALTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9E9</accession>
    <name>F4F9E9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase nad-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732014.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11125"/>
    <dbReference type="EnsemblBacteria" id="AEB43343">
        <property type="protein sequence ID" value="AEB43343"/>
        <property type="gene ID" value="VAB18032_11125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11125"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_11"/>
    <dbReference type="OMA" id="WHHGTDK"/>
    <dbReference type="OrthoDB" id="1435073at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="2">
        <location>
            <begin position="102"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="32948" checksum="EB83182634C587B0" modified="2011-06-28" version="1">MKVWIPHETGHDLLGELPPEVVVETMSDPARLPSSTSGVRFWVPPFLAPAAATALLSELPDLAVVQLLSAGADTWVGRIPPGVVLCDARGVHDPSTAEWVVTAILSQLRGFPAMVRAQAQRRWVYDEVAPTDELAGKRILIVGAGSIGTAVRDRLAPFEVQFDLVARTARPEQGVHGVDALPTLLPQVDVVVLLVPLTEQTRGLVDKSFLAAMRDGALLVNAARGPVVVTEALVAEVAGGRLRAALDVTDPEPLPADHPLWELPNVLITPHVAGSVRGLLPRAYRLVGQQIRRFVAGEQPDNVVVDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9F0</accession>
    <name>F4F9F0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732015.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11130"/>
    <dbReference type="EnsemblBacteria" id="AEB43344">
        <property type="protein sequence ID" value="AEB43344"/>
        <property type="gene ID" value="VAB18032_11130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11130"/>
    <dbReference type="eggNOG" id="ENOG5033EBJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139572_0_0_11"/>
    <dbReference type="OMA" id="VAVWAWR"/>
    <dbReference type="OrthoDB" id="2011606at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="14339" checksum="1EA3F6DF4685746B" modified="2011-06-28" version="1">MSRTDTTRFRHHQAILVGAIIATIGALPLADARAYLLPVLLVPLAVAVWAWRAGTDANPHGLRLRALLGDRLIRWDQIVELGGDTRGRAVALLTDGRRLVLPAVRHVDLPRLVAAAERGEPVADRDDVPVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9F9</accession>
    <name>F4F9F9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_11175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11175"/>
    <dbReference type="EnsemblBacteria" id="AEB43353">
        <property type="protein sequence ID" value="AEB43353"/>
        <property type="gene ID" value="VAB18032_11175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11175"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_13_1_11"/>
    <dbReference type="OMA" id="VTNKFPI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="446"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="566" mass="57562" checksum="B4B1F3944FE4F970" modified="2011-06-28" version="1">MNGTDAATPATPRPALAAAWGRVRALLPGRADLQAVRRAPRRDLLAGLTVAIVALPLALAFGVTSGLGAEAGLITAVVAGAVAAVFGGSNLQVSGPTGAMTVVLVPIVAQFGANGVLLVGAMAGVILLVLAFARFGRFVRYLPVPVIEGFTAGIAVVIALQQVPAALGVTDAQGERVWAVAADAVARFVVHPHPAAIAVALGVAAVMLVGARWRPGVPFSLLAVAAATIIAELVPVDLIRIGALPQTLPAPSLDFLDLGAVGVLLPAAFAVAALAALESLLSATVADGMTVDQRHDPDRELFGQGLANLASPLFGGIPATAAIARTAVNVRAGAVSRLAALTHAVALAGIVLAAAPLVGRIPLAALAGVLLATTVRMVEAASLWALARATRGDALVLVLTFAVTVIWDLVTAVAVGVAVAIVVALRAVARSAKMEQVPLDADDHTAEEQALLAEHIVAYRLDGPLFFAAAHNFLLQLSDVADVRVVILRMARVTTIDATGAQVLGDAIRRLQGRGITVLLSGIDPGHDQVLDTLGVADQLRRDNLIFPDTPAAIAYARVLALPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9R7</accession>
    <name>F4F9R7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase s8 and s53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_23725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734495.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23725"/>
    <dbReference type="MEROPS" id="S08.091"/>
    <dbReference type="EnsemblBacteria" id="AEB45843">
        <property type="protein sequence ID" value="AEB45843"/>
        <property type="gene ID" value="VAB18032_23725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23725"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_17_3_11"/>
    <dbReference type="OMA" id="RIHAWKI"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307749" evidence="6">
        <location>
            <begin position="30"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="158"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="498" mass="50687" checksum="1D923E6FEF245DC3" modified="2011-06-28" version="1">MKKLGRKALAVAVAVALGAGVTSVVTAPATASVDGGEAHGGEATFLVLTPQGATVDRALARVAAADGTVIADYRQIGVLVVRSANRDFVADTAGAGVESVASTAGLGTVLDEGHTVELTTGELAAVGGDPSTEPLFAQQWNMPMIDLPRAHTVTAGSADVVVGVLDSGISSSHPDLAGQLARDKSASCLGGVADTTEAAWNPTTSDHGTHVAGTIAAARNGVGVTGVAPGVKVAAVKVVDNEGYIYPEAAVCGFMWAAEQGMQLTNNSYYLDPWELNCRNDARQRPVWQAVQRAIRYSQSKGVLTVASAGNANHDLAHRFVDSGSPNNGTPEVREVNGACLVLPAQAPGVVTVAAVGPTGQKSYYSSYGQGVVDVTAPGGDSRIRTQGLTPTTADAILSTTFNTVTRIDGWGWKQGTSMSGPHVTGVAALALSARPGMTPGQLAALLERTAVPQPCPAGGYDPIPLLPSATDYTATCQGGTRNGFHGAGLVNAYRAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9S6</accession>
    <name>F4F9S6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide synthesis cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734504.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23770"/>
    <dbReference type="EnsemblBacteria" id="AEB45852">
        <property type="protein sequence ID" value="AEB45852"/>
        <property type="gene ID" value="VAB18032_23770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23770"/>
    <dbReference type="eggNOG" id="ENOG50332TT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2207266_0_0_11"/>
    <dbReference type="OMA" id="WRSPKDA"/>
    <dbReference type="OrthoDB" id="1788762at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006765">
        <property type="entry name" value="Polyketide_synth_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038474">
        <property type="entry name" value="Polyketide_synth_cyclase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04673">
        <property type="entry name" value="Cyclase_polyket"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="111" mass="12803" checksum="9BABD5DB205DA094" modified="2011-06-28" version="1">MDRTLIVAKVVPTAENAVAEIFAESDTTELPHLVGVAHRSLYRLHDLYVHLLETDTPGDGAVEAARDHPEFRRISARLRPYITPYLPDWRSPRDAMARCFYRFDAEPRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9U5</accession>
    <name>F4F9U5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phage tail sheath family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_23865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734523.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23865"/>
    <dbReference type="EnsemblBacteria" id="AEB45871">
        <property type="protein sequence ID" value="AEB45871"/>
        <property type="gene ID" value="VAB18032_23865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23865"/>
    <dbReference type="eggNOG" id="COG3497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009303_0_0_11"/>
    <dbReference type="OMA" id="GPRPIEG"/>
    <dbReference type="OrthoDB" id="558210at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="3">
        <location>
            <begin position="202"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="4">
        <location>
            <begin position="300"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="416" mass="44422" checksum="BA83EC4F19866418" modified="2011-06-28" version="1">MPTYFSPGIYVEEVPGAARPIGPAGTSTAAFVGVAPDRTAHLGEALAVNNWTDFLRLYADGDDFESTPLARAVFGFLDNGGTRCWVVNVGEGGSVTGTGRKRAGLDLLEAVDEISIVATPGFHDPVSHEALLSLAERTRSMVAICDPPPDIDDISTLTRVATPGSTRPAKPADTADPDTPGSGGSGGGSGGGGPVSYRPRQSDYGALYYPWLRVRDPLSGDLVLTPPSGHVAGIWARTDALRGVHKAPANEPVRGAVDLGHLVTRAEHDVLNPKGVNVIRYFPGEGIRVWGARTLAAEASEWRYLNVRRLSISIEQAIANGTRWMVFEPNDFTLWRSIRRDIGAFLTRVWRDGALLGRTPEEAFFVKCDEETNPADVRDAGMVVAHIGIAVVKPAEFVVFKLSQWAGGTETETIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9W4</accession>
    <name>F4F9W4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23960"/>
    <dbReference type="EnsemblBacteria" id="AEB45890">
        <property type="protein sequence ID" value="AEB45890"/>
        <property type="gene ID" value="VAB18032_23960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23960"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="FAGNDMI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="31931" checksum="01880B40679FBDA5" modified="2011-06-28" version="1">MAQATVQRVQQVIHQLGYEASLGAQSLRSHRTNVLGILVAEFEPFSTELLKGASAGVTGTGYQLLAYSSGDVAGTAVGWERRSLARLSGTLIDGAVIVTPTVVETKQGFHVVAVDPHTGPSGLPTVDSDNFAGAVLATNYLLSLGHRRIGHISGRADLESSRLREAGFRQAMADAGVTVDERLVRVGGFRIESAAGTAAELLALPDRPTAVFAGNDLSAISTIDVARNMGLSVPDDLSVIGFDNVPESALVNPPLTTIMQPIQRMGAEALRLLVDLIAGVERDIHIRLPTELVVRASCRAVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA13</accession>
    <name>F4FA13_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase m16 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00200"/>
    <dbReference type="EnsemblBacteria" id="AEB47124">
        <property type="protein sequence ID" value="AEB47124"/>
        <property type="gene ID" value="VAB18032_00200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00200"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_1_11"/>
    <dbReference type="OMA" id="FNGSTHL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="156"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="412" mass="45180" checksum="AC592D4332EB5B33" modified="2011-06-28" version="1">MVLTPDRSAPVIGVAVVYDVGIRSEPEGRTGFAHLFEHLMFQGSENLEKLAHFRHVQGAGGTFNGSTHLDYTDYFETLPSNALERALFLEADRMRGPRLTEENLRNQVDVVKEEIRVNVLNRPYGGFPWLTLPPVMFDTFPNAHDGYGSFVDLESATVADAADFFRRYYASGNAVLAVSGDIDVAEATTLIERHFGDVPARPAPQRPDFAEPELTVERRTAYTDQLAPLPAVASGWRVPDPINDFAAYLPYVVLAEVLTDGDASRLVERLVQRDRTVTSVGGYLSFLGDPFDVRDPTALLLQAHLPPGGDVDKVLRTVDEELDRLATDGLADGELARTQARMATHLLRDTDAVLGRALRMAVLEQQRGEPGLLNDLPRLVGAVTDEQVRAAAATLRPERRASVEVIPGGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAA8</accession>
    <name>F4FAA8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730843.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05215"/>
    <dbReference type="EnsemblBacteria" id="AEB42169">
        <property type="protein sequence ID" value="AEB42169"/>
        <property type="gene ID" value="VAB18032_05215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05215"/>
    <dbReference type="eggNOG" id="ENOG50344NV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1615581_0_0_11"/>
    <dbReference type="OMA" id="ILNWIAI"/>
    <dbReference type="OrthoDB" id="1908972at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="170" mass="18384" checksum="707D4279AE875757" modified="2011-06-28" version="1">MSPSVALTILNWIAILILFLAVGALLREVRMLRALVVREVSYSSAGPDLVLGATVTDGADRVVLASDTGCPLCGAVTARLAELADAAGIRPVLLTYEDVEQWPEAVRQEFDVVSDRDEWQKIAHLSPPVLMAVRADGRVVDLTLPVDVGSAERQFDLVRKKILHREGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAF9</accession>
    <name>F4FAF9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="13" type="ordered locus">VAB18032_11340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11340"/>
    <dbReference type="EnsemblBacteria" id="AEB43386">
        <property type="protein sequence ID" value="AEB43386"/>
        <property type="gene ID" value="VAB18032_11340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11340"/>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009678_5_0_11"/>
    <dbReference type="OMA" id="NIKWARK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="10">
        <location>
            <begin position="54"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="9">
        <location>
            <begin position="169"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="12">
        <location>
            <begin position="377"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="11">
        <location>
            <begin position="550"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB43386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="734" mass="81411" checksum="50702CF82B103A90" modified="2011-06-28" version="1">MSTPRERPDHSVGTDPAASSAGLEEVLDPVSGAGLPEPADRETSFDRPLPEDRFLNRELSWLDFNARVLALAEDHRTPLLERAKFLAIFASNLDEFYMVRVAGLKRRLTAGLPVRGGDGLPLRTQLELVAAKAADLVARHAACFIDDVSPKLAAEGIRVLRWSDLGDSERDRLRSYFREQIFPVLTPLAVDPAHPFPYISGRSLNLAVSVRDPDGGAELFARVKVPNNVPRFVRVDRDQPGVRMLPVEDLIAVHLGQLFSGMQVVECHLFRVTRNAEVEVDEDRDEDLLQALERELARRRFGPPVRLEVAASISDHMLELLVRELDMDAQDVLRVRGLLDLSALWQLYGEADRPDLKDPPFVPATHPRLAEGEVPRSVFATLRDGDVLVHHPYHSFATSVQRFIEQAAADPHVLAIKQTLYRTSGDSPIVDALVEAAAAGKQVVVLVELKARFDEVANIGWARTLERAGCHVVYGLVGLKTHCKTALVVRQEGNQIRRYCHIGTGNYHPKTARLYEDFGVLTADPEIGADLTDLFNVLTGYSRQTAYRRLLVAPQGIRGGLIERIEREITQVRLGMPGLVQFKVNSLVDEAVTDALYRASQAGVHVDLIIRGMCTLRPGVPGLSDNIRVRSILGRFLEHSRIFRFGNNGDAEFWIGSADMMHRNLDRRVEALVQVSDPVARAELDHVLQAAMSPDVDAFELSADGSWTRRSGTPTTPLVHLQDLLLRRVGSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAG3</accession>
    <name>F4FAG3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Modification methylase, HemK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_11370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732061.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11370"/>
    <dbReference type="EnsemblBacteria" id="AEB43390">
        <property type="protein sequence ID" value="AEB43390"/>
        <property type="gene ID" value="VAB18032_11370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11370"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_4_2_11"/>
    <dbReference type="OMA" id="GWAEFCG"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022446">
        <property type="entry name" value="CHP03704_MeTrfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03704">
        <property type="entry name" value="PrmC_rel_meth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="4">
        <location>
            <begin position="98"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="28299" checksum="F4F28B1C7349D995" modified="2011-06-28" version="1">MIAVSSAVRAATVDRLRRAGCVWAEDEARLLVEAADDPRSLAVLVDRRVAGEPLEYLLGWAEFCGERITVVPGVFVPRARTAALVAAAEAVTGPAARVVELCCGSGALTRALARRLHAPRLLAAVDVDPAAVACARGNLAELAVPVYAGDLFDALPATWRGTLDLVVANAPYVPTAALDLLPAESRRYEALVALDGGPDGLAVLRRLAADATRWLAPGGHLVVEVGQSQVDLLATVLAEAGLLPSTFRDESLAATAMTARRPVGMAGQGSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAI8</accession>
    <name>F4FAI8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase domain-containing protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732085.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11505"/>
    <dbReference type="EnsemblBacteria" id="AEB43415">
        <property type="protein sequence ID" value="AEB43415"/>
        <property type="gene ID" value="VAB18032_11505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11505"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_9_4_11"/>
    <dbReference type="OMA" id="EYFQAAC"/>
    <dbReference type="OrthoDB" id="1669868at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="206" mass="22290" checksum="80253BD6F8108385" modified="2011-06-28" version="1">MARERATALLVDFDGVLRRWDPAVAAGVEREYGLSAGVLGEIATSWGLLQPVLTGRVSHTDWMSSVADALTPSVGDPDRARAAVEQWQRYRGEVDPQVLAFIREVRAAGIRVGLGTNATDQLDADLTALDLTDELDVVVNSSAIGIHKPAKEYFQAACVALETPPDRVLFVDDEDRAISGARVAGLSAYRWNGPEDLRYLRAALAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAM8</accession>
    <name>F4FAM8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent transcriptional regulator, malt-like, luxr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17705"/>
    <dbReference type="EnsemblBacteria" id="AEB44643">
        <property type="protein sequence ID" value="AEB44643"/>
        <property type="gene ID" value="VAB18032_17705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17705"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055636_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="225"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="31071" checksum="6236831942418077" modified="2011-06-28" version="1">MARAAGQHATAGVHLGLLAVLSAVRADHDACLGHVAELGDTAAPGSRPYALAQWALGVLDLVDGRYADAADRLATLARPGTGRGQVLVQVMATPHLVEAAAHDGRTARARAALAVFDHWAGSTASPLRRALSARCHALLAPRGSTEAEEHFDRALCLHPADAATFERARTELLYGRELRRNRRPRDARDHLHRARQTFVLLGADVWARQTTVELRAAGESVGTPDRQAVRLLTGQQLRIAQLVAAGATNREVATQMFLSTRTIDHHLRNIYHRLGIRSRTELARALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAN0</accession>
    <name>F4FAN0_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">VAB18032_17715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44645">
        <property type="protein sequence ID" value="AEB44645"/>
        <property type="gene ID" value="VAB18032_17715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17715"/>
    <dbReference type="eggNOG" id="ENOG5030VJM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2572936_0_0_11"/>
    <dbReference type="OMA" id="THWHREP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="81" mass="9443" checksum="CCAE3F415A639A51" modified="2011-06-28" version="1">MAIRSELRDILRWLLRRADLPPPPGTGQRHQAAEQAAAQRRLLDQAKRSRDTHWHREPIQTTPYAPTTRDQRTGDATRSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB45</accession>
    <name>F4FB45_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735835.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00530"/>
    <dbReference type="EnsemblBacteria" id="AEB47190">
        <property type="protein sequence ID" value="AEB47190"/>
        <property type="gene ID" value="VAB18032_00530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00530"/>
    <dbReference type="eggNOG" id="ENOG503353J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101812_0_0_11"/>
    <dbReference type="OMA" id="VHDQQTV"/>
    <dbReference type="OrthoDB" id="2077327at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="24083" checksum="76510C7CC77216F4" modified="2011-06-28" version="1">MQPGNPGQDPYGQQPPYGDPTSSPPANPYAPPPANPYAPPPANPYTPPADPYTPPADPYGPADNAPADPYGQQPSGPPPVSPAPYDPYAPPPAAQPPAYGQPPAYGQEPAYGQPAYGQPQVSGQPYGQPYADPYAAQQPYGGAPMYPQAGFGGPSGPQNTLGLLSMILGIASIPLSCCYLGIPLGAAALITGWLGKQKADQGLANNSGQALTGLICGGVGALFGVLQIVLLVVNVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB67</accession>
    <name>F4FB67_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00640"/>
    <dbReference type="EnsemblBacteria" id="AEB47212">
        <property type="protein sequence ID" value="AEB47212"/>
        <property type="gene ID" value="VAB18032_00640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00640"/>
    <dbReference type="HOGENOM" id="CLU_123834_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="13440" checksum="66A6DB8667705EBD" modified="2011-06-28" version="1">MRAHRTDLVSFAFGLLFLALAAWWLLAQVVGLVLPPVGWFLAGGLILIGLLGLVGALRSSKQANQPEQPGPGPAGSDTAGTGGHEATESPDARQDEAAGTGTDADRSTDDDRTLDLADDADLPRRRGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBB7</accession>
    <name>F4FBB7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730886.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05435"/>
    <dbReference type="EnsemblBacteria" id="AEB42213">
        <property type="protein sequence ID" value="AEB42213"/>
        <property type="gene ID" value="VAB18032_05435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05435"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038455_0_0_11"/>
    <dbReference type="OMA" id="NDMANVT"/>
    <dbReference type="OrthoDB" id="783523at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307776" evidence="2">
        <location>
            <begin position="27"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="217"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="447" mass="45897" checksum="766561C63535A075" modified="2011-06-28" version="1">MHMSRGTRGAVMAVCATLLLATSACGDDQPEEATAHQVRLYGTDGNMSNSYAEELGDRANLVDGMKGTTPLTPLPEDFKKRLLSVDPKLDGFLYAAESYDAVVISALAAEVAGTTDPTAIAKQIVGVTNTGTRCGTVAQCLRLIREGKDIEYRSVSITRAGFTDVGEPATASYATLHFDGQQLNDAKTEFVGAGDESAASNKRPPRGNASSSPDGPLVIGGLLPKTGDLAIAYPPLAAGAALAIKEINAAGGVLGEEVVWVDGDDGTNPAIAKATVARHVDGGVHVIIGAGGSGISAAVLEDVVKAGRILFSPSNTAANLTEVDDRGLYFRTAPPDGLQGRALADVILRDGPQKIAIVARKDSYGEGLQGIVRAELERAGFGGDKVKLLGYQPGEDANAAPIDFSAGAKEIKDFGADAVLIIGFGESAAVVRALADADVPLAALANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBE4</accession>
    <name>F4FBE4_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730913.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05570"/>
    <dbReference type="EnsemblBacteria" id="AEB42240">
        <property type="protein sequence ID" value="AEB42240"/>
        <property type="gene ID" value="VAB18032_05570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05570"/>
    <dbReference type="eggNOG" id="ENOG50336WP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1440133_0_0_11"/>
    <dbReference type="OMA" id="CLDATGW"/>
    <dbReference type="OrthoDB" id="1880928at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309214" evidence="1">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="188" mass="19953" checksum="0C8C371BF6E1DC61" modified="2011-06-28" version="1">MRARQLSRWTAGLVAVATVGTTTACGNPPTTAGTTATDRSRPVGNERIAEEKAAEQAALKAYAGYLTASRSASRRSDPQHPELTRFLADPLLTRVRVGLIKARANGAVSTGTLRSDPTVISVDLDGKPPTVEIQDCLDATGYRLVYVADKKVVPGTRGTRHLATAVATRYPDGRWLISGGSAHQDQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBJ2</accession>
    <name>F4FBJ2_MICM1</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732123.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11700"/>
    <dbReference type="EnsemblBacteria" id="AEB43454">
        <property type="protein sequence ID" value="AEB43454"/>
        <property type="gene ID" value="VAB18032_11700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11700"/>
    <dbReference type="eggNOG" id="ENOG502ZVDD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166791_1_0_11"/>
    <dbReference type="OMA" id="QHKPGHR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024341">
        <property type="entry name" value="DUF2631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10939">
        <property type="entry name" value="DUF2631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="73" mass="7733" checksum="9FA1A406153ABB56" modified="2011-06-28" version="1">MAGSEPVTSPDQHKPGHRKSGRIGAILTALALLAMLCGNHEGRVENLWLIGLAALLLLIVIGDAVLRRNGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBQ7</accession>
    <name>F4FBQ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733362.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18025"/>
    <dbReference type="EnsemblBacteria" id="AEB44707">
        <property type="protein sequence ID" value="AEB44707"/>
        <property type="gene ID" value="VAB18032_18025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18025"/>
    <dbReference type="HOGENOM" id="CLU_2621064_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="78" mass="8517" checksum="10077B73A5C3CB6F" modified="2011-06-28" version="1">MSGRLRRLIVAVAGTTWRGLVLYGSSMTGVPLDETGQWPGPWTQTTGRLPTASPPDRPLTAQEQMAWTQLENRIAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBQ9</accession>
    <name>F4FBQ9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18035"/>
    <dbReference type="EnsemblBacteria" id="AEB44709">
        <property type="protein sequence ID" value="AEB44709"/>
        <property type="gene ID" value="VAB18032_18035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18035"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160055_0_0_11"/>
    <dbReference type="OMA" id="LGQWLIR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="103" mass="12009" checksum="F3108178F0452A0D" modified="2011-06-28" version="1">MIGVFRVLLTMQVDPDRSTEFEQVWGEVARSIGQESANLAQELYREPGSVYHVVTDWTDEESFRRFETSESHRGHRARLDPFRCAVRMTTMRLVHRLPADRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBU3</accession>
    <name>F4FBU3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18205"/>
    <dbReference type="EnsemblBacteria" id="AEB44743">
        <property type="protein sequence ID" value="AEB44743"/>
        <property type="gene ID" value="VAB18032_18205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18205"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_11"/>
    <dbReference type="OMA" id="MKMHACG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="186"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="414" mass="43397" checksum="310248D3D7C04222" modified="2011-06-28" version="1">MELGHDGVEGLVRLRRQLHRHPELRFTEHQTAVTLAEKLQPFGRVRTGIAGTGLLLELEGALPGPTVLLRADMDAYPVQDAKTEPYASTNPGVCHACGHDVHMTVAYGVAARLAATPPARGSVAVLFQPAEEIPFGEASGAAAALLHEALSGRRFDAVLGLHCWPDLRVGTVGVDRHTAMAAKDAFRIEVLGRAAHAATPALGRDAILGLSGIVNLLHAAVARSRNADELVAFNIGTISGGASQSQVAAYAEATGTLRTLDEGTRERLKVVIERVARQQAAALDLGVRFTWANEMPPVRNAAELVALAHTELPDLVEVVDLAVPPLTTDDFALLGALGPSLYVKLGVTGERGGAPLHSGSFDVDERCLEYGVNALERLTRAVLDGRLTAPTIASVPTPAAAADDTDTDSAAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBW0</accession>
    <name>F4FBW0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733415.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18290"/>
    <dbReference type="EnsemblBacteria" id="AEB44760">
        <property type="protein sequence ID" value="AEB44760"/>
        <property type="gene ID" value="VAB18032_18290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18290"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="MKTRREY"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="275" mass="30167" checksum="440C3A8EF9F8A171" modified="2011-06-28" version="1">MSHLRRGRWLIALPMSLLALATIYPLLFTANVAMKTRRDYILDRFALTDALRWDNIITAWTSVGMGRYFINSLVVVTSSVILLLLLGSMAGFALSQLRFRGSSALFLGCLAGLFVPFQVIMVPLARIMADTALIDTYPGLVLVYVAQFLPFTVFLMTSYYRGVPPEIIDAARIDGNSIYGVYRRIMLPLGTPALLSVGILNALFCWNDVLMSLVMMPSAEHRTLMVGVTSLRGQYSDDIPTFASGVLIAAIPVLVVYLFLQRQIADGVAAGSTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBX7</accession>
    <name>F4FBX7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18375"/>
    <dbReference type="EnsemblBacteria" id="AEB44777">
        <property type="protein sequence ID" value="AEB44777"/>
        <property type="gene ID" value="VAB18032_18375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18375"/>
    <dbReference type="eggNOG" id="COG0208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035339_1_1_11"/>
    <dbReference type="OMA" id="KVGEYQR"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="39258" checksum="3B6F1F06CA297C5D" modified="2011-06-28" version="1">MTTVSETQTRQLLLDPGMDLTLRPMRYPQFFDRFKDAIRNTWTVEEVDLHADLADLAKLSPAEQHLVSRLVAFFATGDTIVANNLVLNLYQHINSPEGRLYLSRQLFEEAVHVQFYLNLLDTYVPDEKQRYEAFAAVENIPSIARKAEFCFKWIDSIFELRELKTRADRRAFLLNLICFAACIEGLFFYGAFAYVYFLRSRGVLHGLASGTNWVFRDESMHMAFAFDVVDTVRAEEPDLFDAEMEQQVRDMLAEAVDCEVQFAADLLEQGVSGMPLADMRQYLQHVADRRLAMLGIAPMYGSTNPFAFMELQDVQELSNFFERRVSAYQVGVTGTVAFDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC61</accession>
    <name>F4FC61_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24805"/>
    <dbReference type="EnsemblBacteria" id="AEB46059">
        <property type="protein sequence ID" value="AEB46059"/>
        <property type="gene ID" value="VAB18032_24805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24805"/>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056160_1_0_11"/>
    <dbReference type="OMA" id="NPFRDHG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="31058" checksum="004985F430888388" modified="2011-06-28" version="1">MTSTMSEQAYDLGGVGDTALWMAAYRARESRRPDRLYDDPYAELLAGDKGRSLLTHFHTPHANDDGNPYLAIRTRWFDDLLANLPPGSQAVGLGAGLDTRSYRMDWPEGVTLYEIDQPAVLAYKESRLAGSGAKRRVDCRTIPVNLSDDWVSALAAAGHDPSRPTTWFAEGVLFYLPEEGARQVLRDAAELSAPGSRVAADLVGTGIFKFPYTRQFLKRLEEANSPWQFGVDDLPAFLGSAGWSGVEVVEPGNPSANYGRWPEHASPTNISILPRIYLVSGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC77</accession>
    <name>F4FC77_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_00860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00860"/>
    <dbReference type="EnsemblBacteria" id="AEB47256">
        <property type="protein sequence ID" value="AEB47256"/>
        <property type="gene ID" value="VAB18032_00860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00860"/>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_4_11"/>
    <dbReference type="OMA" id="YGLVEPA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="18"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="6">
        <location>
            <begin position="330"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="4">
        <location>
            <begin position="431"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="491" mass="50927" checksum="C4DA8CDF7F81BA29" modified="2011-06-28" version="1">MSERQRTDRQPDAMSGERVVVVGNGMAGARLAAELHARGQDKVTVVGAEPHRAYNRIMLSTLLAGKIGEPDVELTEATGRGVDLRTGVAVRTIDRAAREVRTDDGDRIGYDHLVLATGARAVVPALPGLDPTSPPDRVVAFRTLADCRRILALAGGARRALVLGGGLLGLEAARGLAARGLDVAVVHRVPYLMERQLDAMAGEILAGTLAELGVTTHLAVTPTGLTADACGVRLSLSDGRTLDADLLVLACGVRPDTALAEAAGLTVDRGVLVDDRLRTSDPRISAIGDCAQHGTAPTGLVAPAWAQARVVAQLLTGQDPQARYHPRPVVTRLKAAGIDLAAMGDPTSGPGEELTFADPARGTYARLRIHDERLAAAILLGDNPSVGTVIQLFDRGQPVPADRRALLLGRAVGGAVAAPAASPALMPDTATVCQCNTVSKGALVTCWRGGARTFDEVVAGTRAGTGCGSCRDAVAGIVDWLSRADPVEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCD5</accession>
    <name>F4FCD5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rplW</name>
        <name evidence="6" type="ordered locus">VAB18032_01150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735952.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01150"/>
    <dbReference type="EnsemblBacteria" id="AEB47314">
        <property type="protein sequence ID" value="AEB47314"/>
        <property type="gene ID" value="VAB18032_01150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01150"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_2_11"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="100" mass="11303" checksum="3FFD97A198EFF3C1" modified="2011-06-28" version="1">MSTIADPRDIIVAPVVSEKSYSELNRNWYTFLVHPDANKTAIKIAIEQIFNVRVLTVNTLNREGKRKRTRTGFGKRKNTKRAMVKLAEGDRIEAFGGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCE4</accession>
    <name>F4FCE4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polymorphic membrane protein Chlamydia</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05725"/>
    <dbReference type="EnsemblBacteria" id="AEB42271">
        <property type="protein sequence ID" value="AEB42271"/>
        <property type="gene ID" value="VAB18032_05725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05725"/>
    <dbReference type="eggNOG" id="ENOG502Z8X0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031783_0_0_11"/>
    <dbReference type="OMA" id="RRILYMN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312896" evidence="2">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="39702" checksum="BB1CB0C0462659FD" modified="2011-06-28" version="1">MVVLGVTVTVLSACGPSVPSADPRSGQPPAVDAAPDASSAAAAEQGGQDVPQTASASPSRSASAVPSVAPTGGGRKPSGGAVAVPAAGRAVDTSRPTRTVGTGTPASCTSAAVVRAVAAGGIITFDCGPDPVTIKMTATAKVRNANGPQVVLDGGGKVTLSGQGQRRILYMNTCDALQGWTTSHCQNQDHPRLTVQNLTFADGDATGQRTDGGGGGAIFVRGGRVKVVNSRFVDNRCDRTGPDVGGAAIRVLDQHDDQPVYVVDSTFVGGSCANGGALSSIGVSWVVLNSTLRDNAAVGEGANPARSGTPGGGSGGAIYCDGNEFSVRIAGTTIEDNDAKEGGGAIFFVSNNRTGTLRIEDSTLRRNPSHGFETYPGIFYLGSGKPTFTRSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCT5</accession>
    <name>F4FCT5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_12325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732248.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12325"/>
    <dbReference type="EnsemblBacteria" id="AEB43579">
        <property type="protein sequence ID" value="AEB43579"/>
        <property type="gene ID" value="VAB18032_12325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12325"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="QVHKYYG"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="27046" checksum="AF4346B325CE71A4" modified="2011-06-28" version="1">MDDVATGEPLIVLDSVNKWFGPLHVLDDVSLSVGRGEVVVVIGPSGSGKSTLCRTINRLEPINSGTITFDGQKLPAEGKALAKLRSEVGMVFQSFNLFAHKTILENVTLGPVKVRKEKPAAARERGLALLDRVGIANQADKFPAQLSGGQQQRAAIARALAMQPKAMLFDEPTSALDPEMVGEVLDVMTSLARDGMTMVVVTHEMGFARHAANRVIFMADGKLVEDAAPAEFFANPRSERAKDFLSKILTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCX5</accession>
    <name>F4FCX5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_18525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18525"/>
    <dbReference type="EnsemblBacteria" id="AEB44807">
        <property type="protein sequence ID" value="AEB44807"/>
        <property type="gene ID" value="VAB18032_18525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18525"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_4_11"/>
    <dbReference type="OMA" id="MDEMGVE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="8">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="9">
        <location>
            <begin position="132"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB44807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="189" mass="20900" checksum="A9B22FD5C24B15EA" modified="2011-06-28" version="1">MSTVPNESIGPSSSDSATVETPATETLLGQIVEEYRRPLHRFLTRLLLGQQELAEDLVQETFLRAWRNADRLAADPSKIAPWLYTVARHVAIDAMRARQARPPEVSLPDLNRVPTTDDEMDRVVNVHAVRLALGKISPEHRAVLIEMYYRGASVAEAAMRLGIPEGTVKSRAYYAVRALHAAIGSTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD40</accession>
    <name>F4FD40_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24860"/>
    <dbReference type="EnsemblBacteria" id="AEB46070">
        <property type="protein sequence ID" value="AEB46070"/>
        <property type="gene ID" value="VAB18032_24860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24860"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082704_0_0_11"/>
    <dbReference type="OMA" id="RYHEPLS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="266" mass="28993" checksum="B1C5D529D787C66A" modified="2011-06-28" version="1">MNIPSRSLYRYVTESPAEKGVERAIAVMYDNLADPVTIDDMARAAMFSKFHFARMFHRATGVSPGRFLSALRLQHAKRLLLDTSLYVSDISLQVGYNSVGTFSTRFTQHVGLSPTTFRRQQGFTPVIGTTAARGGRGQVHGEIRSPGSPPGLIFVGLFADRMPAGWPVRCTLLDRPGRFALTDVPDGDWYLLAHFVGTTDLDEAASHAYTGADGLAVGVYGPLRVRGRAVHAELGLRPMTLLDPPVLMALLDARKAAREVLARRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD79</accession>
    <name>F4FD79_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734761.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25055"/>
    <dbReference type="EnsemblBacteria" id="AEB46109">
        <property type="protein sequence ID" value="AEB46109"/>
        <property type="gene ID" value="VAB18032_25055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25055"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026152_4_2_11"/>
    <dbReference type="OMA" id="RDVHWKS"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="185"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="40998" checksum="C6B41D0F3DC1FAFC" modified="2011-06-28" version="1">MGITARGIGLLVAGVLLLGTGFRFGYPELTVLGAAAGVAVAVAVLSAAWRPRLQVRRQADPDRVARGEPAAMTLTVRNMGRLRSASLLAADRCGDQVVPVPVLRLRPGADTTVRYEVPTARRGVVPVGPLRVTRRDPLGLVVVARSYGDSVPVWVHPTIHPLRAVPTGAGRSLDGRVDSVPHGSITFDSLREYVVGDELRRVHWRTSARVGELMVRENVDTSLPRIVVLLDNRLAAHPQRVRGVAESFESACEAAASVVTAAVREDLPVTLLFVAAPDDLAGASTAADGSGDGGPTGPLDRLAAVSLSDEGTLEAAAARLRRDRLGDTLVVLTGPGGRDDLGHVGALRGAYPSVVVGVFGAAEPTPPGTGGLLVVDAADGAGFAAEWDGVRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDC3</accession>
    <name>F4FDC3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ordered locus">VAB18032_01250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007073056.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01250"/>
    <dbReference type="EnsemblBacteria" id="AEB47334">
        <property type="protein sequence ID" value="AEB47334"/>
        <property type="gene ID" value="VAB18032_01250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01250"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_11"/>
    <dbReference type="OMA" id="RYTTMKN"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="6624" checksum="1C70DDF2466C1C5F" modified="2011-06-28" version="1">MAKATDVRPKITLACVECKERNYITRKNRRNDPDRIELKKFCPRDGRHTVHRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDL6</accession>
    <name>F4FDL6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VHL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06275"/>
    <dbReference type="EnsemblBacteria" id="AEB42379">
        <property type="protein sequence ID" value="AEB42379"/>
        <property type="gene ID" value="VAB18032_06275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06275"/>
    <dbReference type="eggNOG" id="COG3115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962475_0_0_11"/>
    <dbReference type="OMA" id="PADHERD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024053">
        <property type="entry name" value="VHL_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037140">
        <property type="entry name" value="VHL_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01847">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49468">
        <property type="entry name" value="SSF49468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="VHL" evidence="3">
        <location>
            <begin position="221"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="32232" checksum="CF33A825D3B880AA" modified="2011-06-28" version="1">MTQPQDHDHARRQPRLRIGPWLPDPDSDTMPPTRLASSATPAGPALSTPPDLSGHQPSASPSEPMVVPIDPTPHPTDRRSHRLILAGVGTAVLGLLLTALWPTTPPPPVAEPPTPPGRFGWPHAPDLPWPPPGTLTPSAPQASSSVGGVSSTRPIAPSQVSSPTRSPSSAAATRTSPAATRTTSPAAPSASPSRTVRPTPSPRPAEPRELTPLPPWRERDLRSVSGGQETSIEFVNHRSRSVIVYWLDHHGHRRQYAVLEPSESYQQHTYVGHPWVVTDRRGRSLACFEPTANPARAVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDP7</accession>
    <name>F4FDP7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731083.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06430"/>
    <dbReference type="EnsemblBacteria" id="AEB42410">
        <property type="protein sequence ID" value="AEB42410"/>
        <property type="gene ID" value="VAB18032_06430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06430"/>
    <dbReference type="eggNOG" id="ENOG502ZU0T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299146_0_0_11"/>
    <dbReference type="OrthoDB" id="1983712at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="22935" checksum="AF664FA080B52BA3" modified="2011-06-28" version="1">MAELQGFRPAIRFAAARNGLVALLLSVVLGLTTAWIGANAVYVPASTPTGETLMPLWKPLSMCAAVIPVLGLHSSLEDLDVVATSRLRRMENLYLATISGVGAMVFVGLAAVALPADQLLPMIRSLPTWFGLALLSGRVAGWRLAWVLPLTAGTMLIYLASGDRIEWWDITEPTGSWGAYGLSVVCLLVGLCAHWLTAWRRRSLLTLLRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDS8</accession>
    <name>F4FDS8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_12475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732278.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12475"/>
    <dbReference type="EnsemblBacteria" id="AEB43609">
        <property type="protein sequence ID" value="AEB43609"/>
        <property type="gene ID" value="VAB18032_12475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12475"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_11"/>
    <dbReference type="OMA" id="SMEMTIE"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="335" mass="37387" checksum="6FA7FC19A97C77F8" modified="2011-06-28" version="1">MGLQMMEHRTSVGIEAEPGIDTLTDLDATDERGVSTDLVRAYLNGIGRTKLLTAAQEVELAKRIEAGLFAEEKLTTCTPVSAQLQADLTLIAQEGQAAKNHLLEANLRLVVSIAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEQVNRMVRARRELSVSLGREPSVAEIARALDVPEFQVIELISYDREPVSLDQTVGEDGESALGDFVAAVDPSSMVDDADRGELRNEVSIVLATLSQREQAVIRLRFGLDDGRQRTLDEVGREFGLSRERIRQIEKVTLLKLRAPERAQRLEAYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE71</accession>
    <name>F4FE71_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Soluble pyridine nucleotide transhydrogenase</fullName>
            <ecNumber evidence="5">1.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733595.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19190"/>
    <dbReference type="EnsemblBacteria" id="AEB44940">
        <property type="protein sequence ID" value="AEB44940"/>
        <property type="gene ID" value="VAB18032_19190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19190"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_0_11"/>
    <dbReference type="OMA" id="SGHAAWH"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003957">
        <property type="term" value="F:NAD(P)+ transhydrogenase (B-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="344"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="467" mass="50298" checksum="389B20A52DA3A326" modified="2011-06-28" version="1">MYDYDVLVLGSGPSGQKAAIAAAKLGRRVGLVERRDMIGGVCINTGTVPSKTLREAVLYLTGLSQRDLYGSSYRVKEDITVSDLAARTQHVINRQTDVIRNQLARNRVTMITGTGRFADAHSVWVDGGSGHESKVTFDKAIIAAGTRPARPDSVDFDDRTIVDSDGVINLQAVPRSMVVVGAGVIGMEYASMFAALGTKVTVVERREKMLDFCDEEVVESLKYHLRDLSVTFRFGEEVAAVEKHQTAALCILKSGKKIAADTVMYSAGRQGQTDGLALEAAGLTADRRGRIEVDAHFRTAVEHIYAVGDVIGFPALASTSMEQGRLAAQHACGEPVRAMHELQPIGIYTIPEISFVGKTEDELTDSATPFEVGIARYRELARGQIVGDSYGMLKLLVSPDDGRLLGVHVFGTGATEIVHIGQAVMGCGGTVDYLVDTVFNYPTLAEAYKVAALDAANKIRNITRIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE86</accession>
    <name>F4FE86_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25270"/>
    <dbReference type="EnsemblBacteria" id="AEB46152">
        <property type="protein sequence ID" value="AEB46152"/>
        <property type="gene ID" value="VAB18032_25270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25270"/>
    <dbReference type="eggNOG" id="ENOG5031ZSZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080168_2_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="27324" checksum="70B0CA3618870B0C" modified="2011-06-28" version="1">MNSTPHGDDHAPHLREHPTPARPVRAVGSAAMPSTVRLADEFFYLAHDDQTGRSRLFESATAYGLAAALLAELYGEGRVTFEGRRLRVINTVPPKDWLQHLVLDRLVAEPRHTETRTWLAYFATAAHEQVATRMWQLGLLRQQQVGRLWRQRTVYVPADMNTAAWSWARLSFQLRNHQRLNAFDVALAGLAVHTQLDPILLDGTPVAVRAFLRQQVEQAPPPLRDLLADLGAVVGSAVLSHRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEM7</accession>
    <name>F4FEM7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01925"/>
    <dbReference type="EnsemblBacteria" id="AEB47469">
        <property type="protein sequence ID" value="AEB47469"/>
        <property type="gene ID" value="VAB18032_01925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01925"/>
    <dbReference type="eggNOG" id="ENOG5031R9K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111492_0_0_11"/>
    <dbReference type="OMA" id="IRKEYAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="187" mass="20304" checksum="5708519E01D7C20F" modified="2011-06-28" version="1">MEPMSDLGALIESVCAERELPCEPTGPGAYAVTLPGTHKLKTICNLIVGEHALRIEAFVMRQPDERREELWAWLLQRNARMYAVSFSIDAVGDIYLTGRVNPAGVDADELDRILGAVLSYADESFDTMLEIGFGSSIRREWEWRVKRGESTANLAAFAHLFEQSGQTPADNPAAAAGAAPEGGAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FES7</accession>
    <name>F4FES7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06735"/>
    <dbReference type="EnsemblBacteria" id="AEB42471">
        <property type="protein sequence ID" value="AEB42471"/>
        <property type="gene ID" value="VAB18032_06735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06735"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153642_0_0_11"/>
    <dbReference type="OMA" id="RNEYTIN"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="110" mass="12132" checksum="B79D7FA40369D35F" modified="2011-06-28" version="1">MGDMATTGERENARNWTFLTNHGHVLLAIARNPTARLRDVADEVGVTERAAQAIVADLEAEGYLQRTRVGRRNEYTLNPSGRFRHPAEADRQVGDLLALFTEEPVAGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF09</accession>
    <name>F4FF09_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732389.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13035"/>
    <dbReference type="EnsemblBacteria" id="AEB43721">
        <property type="protein sequence ID" value="AEB43721"/>
        <property type="gene ID" value="VAB18032_13035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13035"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_11"/>
    <dbReference type="OMA" id="MWWSTYE"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="43277" checksum="97DBED269EE844BC" modified="2011-06-28" version="1">MTAVCTALVVGGGIAGPVTAMALRRAGIEATVYEGHPSAADGAGVTLTLAPNGLAALRAVDAEQAVREVGLPMRRTVITDGRGGLIGTLPHVAVEPVTVGLWRDDLARALRERAEAQGVPIVHGKRLVDAESTTDGVLARFGDGSTATADLLIGADGIRSRVRTLIDPAAPDPQVLPLLNLGGAARYAVPDADPEAMYLVFGSRGFFGYWVEPDGRTAWFANVPDPRPTTWAEANQTPPDQWLHRLREVYADDVPAHQVLAHTDAADVVAIGSIESMPSVPHWYRDRMVLVGDAVHAPSPSSGQGASLAVESAVQLARCLRDHPDLPAALTAYERLRRPRVEKVVRRGRQTTSTKTAGPVAKRMMRIMMPLALRTFLNPERSLGAEQRYRIDWDAPVSAELAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFC3</accession>
    <name>F4FFC3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Had-superfamily hydrolase, subfamily iia</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734877.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25635"/>
    <dbReference type="EnsemblBacteria" id="AEB46225">
        <property type="protein sequence ID" value="AEB46225"/>
        <property type="gene ID" value="VAB18032_25635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25635"/>
    <dbReference type="eggNOG" id="COG0647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_1_1_11"/>
    <dbReference type="OMA" id="MDGVLIH"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="27901" checksum="228944BD999B5E10" modified="2011-06-28" version="1">MHDRKPVESWLTDMDGVLVHEGQPVPGAPEFIKRMRASGKPFLVLTNNSIYTPRDLRARLARMGLDVPEQAIWSSALATAQFLADQRPGGTAYVIGEAGLTTALHAVGYVLSDFAPDYVVLGETRTYSFEAITKAIRLINDGARFICTNPDATGPSVEGALPAAGSVAAMISKATGVEPYFVGKPNPMMMRSALNTIDAHSESTAMIGDRMDTDILCGLEAGLETILVLTGISTRTEAERYPYRPSRIVNSVADLIDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFF3</accession>
    <name>F4FFF3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734907.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25785"/>
    <dbReference type="EnsemblBacteria" id="AEB46255">
        <property type="protein sequence ID" value="AEB46255"/>
        <property type="gene ID" value="VAB18032_25785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25785"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="OMA" id="CFEGTEV"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="21771" checksum="7253AD6CF600481D" modified="2011-06-28" version="1">MDYGHSERPSGAVALPTAIKILVAGGFGVGKTTLVGAVSETRPLRTEEVLTESGVGIDDLSGVEAKRTTTVAMDFGRITISDDLVLYLFGTPGQDRFWFVWDELALGAIGAVVLADTRRLADCFPSIDYFEGRGTPFLVAVNCFEGARHYRLDEVQAALNLDPEVPVLLCDARQRESAKEVLITLVEHAMKLREARRSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFF6</accession>
    <name>F4FFF6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_25800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734910.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25800"/>
    <dbReference type="EnsemblBacteria" id="AEB46258">
        <property type="protein sequence ID" value="AEB46258"/>
        <property type="gene ID" value="VAB18032_25800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25800"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002554_2_2_11"/>
    <dbReference type="OMA" id="MERREHD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NIT" evidence="9">
        <location>
            <begin position="49"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="330"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="516"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="855" mass="92363" checksum="D7BD4BE82CADD534" modified="2011-06-28" version="1">MGSRSSNLRTKVVALLASLVALWGFTAWVTVREGVNLVGVQALDVRVFDPTEPLLLQLQLERRNSVVYLGRPEESQRAELEKLRQRTDELAGEFVESTDHWQVSLLGSKDLHERIDALNRGLSVLSETRTAVDQRNISRSEAMTAFTELIEAIFEVYDELGNLDDDEVAENTAQLIRLNRARELVSQEDAMLAGILAAGRITQTERAEFTRVVGARQFLAEQAVVRLPETDQRRYEQMMAGANFTRLANLENQVMLATGTSRPPFDSQKWNEASAAALVEIGDVVLAGGDEIVKRATPVAIGVIVRLVLAAGLGLLAVIASVVVSITTARALVQQLQRLRDAAIQLADERLPSVVERLGRGDQVDVAKEAPPLRFGDDEIGQVGKAFNVVQETAIRTAVEQAELRRAVREVFLSLARRTQALVHRQLTLLDAMERREHDAEELEDLFRVDHLATRMRRNAENLIVLSGSTPGRAWRRSVPMVDVIRGAVGEVEDYTRVTVLPIGGVSLAGRAVGDVIHLLAELIENGLSFSPPHTSVEVRGQLVANGFAIEIEDRGLGMTEEDLAAANHRIVDQSELNLADASRLGLYVVSRLTDRHGVRVRLKESAYGGTTAVVLIPSNLIIVDGSEPEALAGPDADTSTRSAEPVPGTAVQRSAAPVALAAPAQPPAPRPDRDVDDEHRGADRRAADSPAEVHLSATDTSEGGLPTRSRRRPGHSALDGPTIPISLPVTGSPGPGLPQRPLDTRDQPADVPAPAGGAPAATEPGEAGLVESVRTESGLPVRIRQASITPALRAEPEAAEEDEDVIREPEQVRRMMSSYQTGTRRGRTDAARLLGGGGRPGDADESDGADQQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFI7</accession>
    <name>F4FFI7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734940.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25955"/>
    <dbReference type="EnsemblBacteria" id="AEB46289">
        <property type="protein sequence ID" value="AEB46289"/>
        <property type="gene ID" value="VAB18032_25955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25955"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070819_0_0_11"/>
    <dbReference type="OMA" id="STWDYSW"/>
    <dbReference type="OrthoDB" id="878336at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="33105" checksum="F060186D75F62A25" modified="2011-06-28" version="1">MTDHHQPARGKPRVALVTCTEFAELEADDRLVIAPLAARDIAAEPVVWDDPAVDWAGYDLVVLRSPWDYMSRRDDFVAWAAGVPRLVNPADVVRWNTDKRYLDELRAAGVPTVPTGWVLPGESWQPPADGEYVIKPSISAGSQDTGRYDMADPEHRELAVAHVRRLGDAGRIAMIQPYLSAVDAAGETALLYFAGPQGLAFSHAIRKGPMLSGPDLGTEGLYKPEEISPRTATADQLAVAERTLAVVPGGTDRLLYARVDLIPGPDGTPVLVELELTEPSLFLGYAPGTPDRLAEAIHTHLTHAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFJ0</accession>
    <name>F4FFJ0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_25970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734943.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25970"/>
    <dbReference type="EnsemblBacteria" id="AEB46292">
        <property type="protein sequence ID" value="AEB46292"/>
        <property type="gene ID" value="VAB18032_25970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25970"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_11"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="OrthoDB" id="188169at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="712" mass="76834" checksum="63F8A41B9F1D29E3" modified="2011-06-28" version="1">MAAKRPEHPALDWSDLDRRAVDTVRVLAMDAVEKSGNGHPGTAMSLAPAAYLLFNRVMRHNPADPSWPGRDRFVLSAGHSSLTLYIQLFLAGYPLSLDDLKSLRQWGSLTPGHPEHGHTPGVETTTGPLGQGLGNAVGMAMAARRERGLFDPETEPGESVFDHHIWCIASDGDIEEGISHEASALAGHQQLGNLCVIYDDNEISIEDDTRIAMSEDVSARYAAYGWHVQTVDWRRGDADQGDYHENVEELYAALLAARAETGRPSFIALRTIIGWPAPNKQNTGKIHGSALGADEVAATKEILGFDPAGSFEVTEEVLAHTRGALRRGEAEQQEWTTAFGAWSEANPQRRALYDRLAARALPEGWTEALPEFPADAKGVATRAASGKVLGALAPVLPELWGGSADLAESNNTTMKGEPSFVPSQYATKEFPGHEYGRTLHFGIREHAMGAILNGIALHGGTRPYGGTFLVFSDYMRPSVRLAALMKLPVVYVWTHDSIGLGEDGPTHQPVEHLTALRAIPGLDVVRPADANETAWAWRQALEHTDRPTALALSRQPLPTLDRSQLAGADGVAKGGYVLAEASNGKPQVIIIGTGSEVQLCLTARERLEADGTPTRVVSMPCQEWFFEQDEAYRESVLPRGVKARVSVEAGIAMSWRGIVGDCGESVSLEHYGASAPHSVLFEQFGFTPDRIVAAAHAALTRVGDITGFTTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFV1</accession>
    <name>F4FFV1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07035"/>
    <dbReference type="EnsemblBacteria" id="AEB42531">
        <property type="protein sequence ID" value="AEB42531"/>
        <property type="gene ID" value="VAB18032_07035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07035"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_23_7_11"/>
    <dbReference type="OMA" id="GATPCSI"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="537" mass="56329" checksum="95CB755376B9BDA2" modified="2011-06-28" version="1">MTGPLAWLDRPDERRGIRFAEPDGSWRFWSYAELADLVRRYAAALRDTGVGAGDVVSIVETTGPRFVGLLFGSMLAGAAASPVAPPPPFGDRERWTEHLHGVLRASTPRLVVHDPALPLVAEVCAGAGVPAYDGEGLLAGGDNRWAAAPTSDGLALVQFTSGSSGRVRGVRVPRPALAATVAGIQGWLRMTPDDPTASWLPVHHDMGLVGCLLAPVATGSDLWLMSPGDFVRRPLRYLECFGRHGARLTAMPAFGLDHIIRRVPRRALTGMDFSAWRAVIVGAERIQPTLLTEFARFAAPHGLRREALLPAYGLAEATLSVTGVPLDTGWRTATVEQGEVVGCGRPLAGAQVTVVDDDGRIVEDGTVGEIVVRGPSVAAGYLPANSDGTASVTRLIDGEVHTGDAGFLVDGELFVLGRLGDGVKVRGRMLLAEDVEAAAVSACGAPVGRITALLGQVGDAPRVVLLLVRPEPDWLTAACAAAEVAAEGVPVEAVVVPAGAVARTSSGKPRRRLMWQDYLAGRLRSAEPVPAGPPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFZ5</accession>
    <name>F4FFZ5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731248.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07255"/>
    <dbReference type="EnsemblBacteria" id="AEB42575">
        <property type="protein sequence ID" value="AEB42575"/>
        <property type="gene ID" value="VAB18032_07255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07255"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_1_11"/>
    <dbReference type="OMA" id="GRTHRHF"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="34867" checksum="30245239B155E868" modified="2011-06-28" version="1">MARHPHTSSAPAGYVTGVDLGGTKVLAALADLTGHIVAEDVLATDPRGGTAVAAQIDTLLRGLARRGGVDWSQVRATAVGLPGAPDPETGTVGLSPNVSELGAFDVRTELTRRLGHPVVLDNDVNMAAAGERWLGSGRTHRHFVFVAVGTGIGMGIVLDGELVRGARGAAGEISYLPLGTDPFDPANQIRGALEEAVAGSALAARYRTATGEQVGVPVIFDRAAAGDQAARAAIDEEARLIALAAVAVTAVLDPEAVVLGGGIGARVELVEPVRRWVAALSADVPLIKTSQLGDRAGLLGAIAVARQQAGAHPGLPAHPDPAASPVTAELRRNTSFESAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG14</accession>
    <name>F4FG14_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732426.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13220"/>
    <dbReference type="EnsemblBacteria" id="AEB43758">
        <property type="protein sequence ID" value="AEB43758"/>
        <property type="gene ID" value="VAB18032_13220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13220"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_19_1_11"/>
    <dbReference type="OMA" id="LYWDRPK"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="173" mass="18450" checksum="386254A507D8AE80" modified="2011-06-28" version="1">MGIHRLNHAVLYVSDLDRSVAFYRNVLGFRLVPMTPKGFHGAAFLQAPGSTNDHDLGLFALGAQARPSTAGRTTVGLYHLAWEVDTLDELAETARRLTAADALVGASDHGTTKSLYGRDPDGLEFEVVWLVPADRLDDAALAARTRIGRLDLPAEIARYGGATRGGVGISVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG62</accession>
    <name>F4FG62_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43806">
        <property type="protein sequence ID" value="AEB43806"/>
        <property type="gene ID" value="VAB18032_13470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13470"/>
    <dbReference type="HOGENOM" id="CLU_1712500_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="15748" checksum="554F2C73F44B566D" modified="2011-06-28" version="1">MRAGIEQQVQPQQSLPGRAARAATTAFIFVALPAFVVFTATTLVAPSVTDDAGVGRVALWAGQVAVLIAIGAAVGALRTPADQPEPPTTWSIVRRLGWHLLSTGACTALVLVLHGLAVGQILTLALLLVGVLHLVPLIVARLLSRAAGRGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG95</accession>
    <name>F4FG95_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHB depolymerase family esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733688.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19655"/>
    <dbReference type="EnsemblBacteria" id="AEB45033">
        <property type="protein sequence ID" value="AEB45033"/>
        <property type="gene ID" value="VAB18032_19655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19655"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_1_0_11"/>
    <dbReference type="OMA" id="KDFNCWD"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313900" evidence="3">
        <location>
            <begin position="36"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="4">
        <location>
            <begin position="349"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="456" mass="48121" checksum="E8207B49719BB92D" modified="2011-06-28" version="1">MEVDVKRTVAALGSLAAASLLAVTGVLFAPSPASAASLVEVTNFGTNPGNMRMHIYVPDVRPANPAVVVAMHGCGGNGPGFYSGSEFGRLADQYGFVVIYPTATQQAGFGNCFDVWSAASKVRNGGSDPVSIMSMVSYAQRQYGGDPQRVYATGSSSGGMMTQALMALYPDVYKAGAAFMGVPFNCFANAADFPPTNSQCVNGRMDRTPQQWGDAVRQAYPGYTGARPRVQLWHGTNDNLIPFQLLQESVEQWTNVAGLSQNPTRTDTPQASWNRRQFADSTGTVRVEAYAIQGAGHSLPSTGMARAAIDFFGLTSTTPPPTTPPPTTPPPTTPPPTTPPPTTPPPTTPPPGATSCRVQWTADTWNNGLVANLTVTNTSPVAVNGWTVQWTWANSQQVTNAWNATITQSGNQVTARNVGYNATIGANQSITFGFQATHTGTNTPPDRFTLNGAACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGA0</accession>
    <name>F4FGA0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733693.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19680"/>
    <dbReference type="EnsemblBacteria" id="AEB45038">
        <property type="protein sequence ID" value="AEB45038"/>
        <property type="gene ID" value="VAB18032_19680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19680"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004617_2_2_11"/>
    <dbReference type="OMA" id="TPWNGDY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="58"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="708" mass="78427" checksum="0B16A698467BF5FB" modified="2011-06-28" version="1">MDWQSQALPIGNGRLGAMLFGQPDHERIQFNEQSLWGGVDDYDNALAGQPDDVFDPSMTGFGCYLAFGDLHLRFHAHQQPDVDYRRALDLESGIHTTRFGAPGRRVRREAFASRSADLLVLHYAAERADALDCDITLTSAQDATATADAGTIAFRGTLGNGLRYAAAVRVAATDGQVRADGHRLQVRSATRLTLLLDARTDYRLDAAARWRGADPEPAVRAALDATAGQPYASLRAAHRARSRAVADRVRVSWGASADEVVALPTDERLARYRAGGVDPELEQTMFVLGRYLLHSSSRPGGLPANLQGLWNDSNQPPWAADYHTNINVQMNYWCAETTDLDDSHRALVEFVRQVAVPSRVATRHAFGAHTRGWTARTSQSIFGGNAWQWNTVASAWYAQHLYEHWAFGQDVGYLRDTAYPMIKEICEFWTDRLVDDGTGRLVAPQGWSPEHGPREDGVPYDHQIIRDLFQNYLDCAAALDVDHDYQATVTDLRSRLAPDRIGRWGQLQEWRADRDDPDDRHRHTSHLFAVYPGRQITPAGSPALAAAALVSLTARCGRHDGGPVSDTTVTGDSRRSWTWPWRAAIFARLGQAPQAWTMLHGLLRHNTLDNLLCTHPPMQTDGNFGITAAIAEMLLQSHDGTIHLLPALPPHWTDGSFAGLRARGGYRVDCVWRAGRVTDFTITADRAPHCDPVVVRCDGRDVLVEPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGA6</accession>
    <name>F4FGA6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733699.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19710"/>
    <dbReference type="EnsemblBacteria" id="AEB45044">
        <property type="protein sequence ID" value="AEB45044"/>
        <property type="gene ID" value="VAB18032_19710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19710"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_11"/>
    <dbReference type="OMA" id="QICMTTG"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="18"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="486" mass="50105" checksum="C9D8880917FE7C06" modified="2011-06-28" version="1">MSLLDTGAWHGTLYSDGWVEAAGGTAAVRSPATGEEIGRVGVADATDVARAAARAAEAQRAWAATSYQERAAVLRRAGALWEQHAAEVGDWIVREAGSIPPKAGVETSTAAQECYEAAALASHPLGEIIPSAQPRLSLARRLPVGVVGVIAPFNFPLILAIRSVAPALALGNAVVLKPDLRTAVSGGLTLAAVFAEAGLPDGLLHVLPGGADTGAALVADPHVRVISFTGSTAAGRKVGEAAARHLKRAHLELGGNSALVVLDDADLDLAVSAGAWGSFLHQGQICMTTGRHLVHASLVERYVEALAEKADHLPVGDPTKEQVALGPIIDEAQRDKIHSLVTASVDAGARLAAGGRYDGLFYRPTVLADVTPATPAYAQEVFGPVAPVLSFTDLDEAAALAADTEYGLSLGILSRDVPKALALADRIPSGIVHINDQTVSDEAVAPFGGVRASGTGSRFGGAAANVEAFTETQWLTVQGDITRYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGD6</accession>
    <name>F4FGD6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_19860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733729.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19860"/>
    <dbReference type="EnsemblBacteria" id="AEB45074">
        <property type="protein sequence ID" value="AEB45074"/>
        <property type="gene ID" value="VAB18032_19860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19860"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_0_11"/>
    <dbReference type="OMA" id="GLEWINW"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="88"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="32032" checksum="E55A9B7825CFF8A2" modified="2011-06-28" version="1">MSVTAPPATRPAAGRPDLTRAALSGRRRFTNHLATAAIWGAVLLAVIPLALVTYTVIGKGAGVMSLSFLTEDIPNSYRREGGGMAPAIIGTLVITGAAALMAIPLGVFGAIYLNEYGKQKPLARVIRLMADVMTGVPSIVMGLFVYISWVLLVGQQTGFAGALALACLMLPVVIRSSEEMLRLVPEELRQASMALGARKWKTTLTVVLPAAISGITSGSLLAVARAAGETAPIIIVTGIVFTPNWNLFDGSNTALPAQIFRNASTSFPAAQDRAWGAALTLIVIVLSFTVIARFISSRFAIKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGE0</accession>
    <name>F4FGE0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733733.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19880"/>
    <dbReference type="EnsemblBacteria" id="AEB45078">
        <property type="protein sequence ID" value="AEB45078"/>
        <property type="gene ID" value="VAB18032_19880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19880"/>
    <dbReference type="eggNOG" id="COG5502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121888_1_0_11"/>
    <dbReference type="OrthoDB" id="1639031at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="128" mass="13319" checksum="383CDAC3D27FF954" modified="2011-06-28" version="1">MRFPLFVDAVSRRSGLSPDLSAGVARAVLRTLAERMTGEPTTDPTGYLPDELSDTAGDPFTTGPGDFLRQVGERAGVDEQTAGLGAAAVFATLREAVTVNEFRALVAGLPTAADGSIDPISGPDETWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGI7</accession>
    <name>F4FGI7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_26120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734973.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26120"/>
    <dbReference type="EnsemblBacteria" id="AEB46322">
        <property type="protein sequence ID" value="AEB46322"/>
        <property type="gene ID" value="VAB18032_26120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26120"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_0_3_11"/>
    <dbReference type="OMA" id="TEEIFVH"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="67" mass="7271" checksum="854CB5691835E7FF" modified="2011-06-28" version="1">MATGTVKWFNSEKGFGFIEQDGGGPDVFVHYSAIASSGYRELTEGQKVEFDVTQGQKGPQADNVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH75</accession>
    <name>F4FH75_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, badm/rrf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732520.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13705"/>
    <dbReference type="EnsemblBacteria" id="AEB43853">
        <property type="protein sequence ID" value="AEB43853"/>
        <property type="gene ID" value="VAB18032_13705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13705"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_2_0_11"/>
    <dbReference type="OMA" id="AQEAFYA"/>
    <dbReference type="OrthoDB" id="1765806at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="146" mass="15582" checksum="E1E5A6A6E40B7B3E" modified="2011-06-28" version="1">MKLNRSTDMAMRIAMLTAASGRRTTVDELAQRLALPRNHVAKVVQRLQHLGVLVTIRGRSGGVAFAADGATYTVGQVVRAFEGDGEVVDCEAPACPLRAACRLRIELRRAQEAFLAVLDRVSLADLVDSPTGPVLLALGAPPAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHA1</accession>
    <name>F4FHA1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">MEP cytidylyltransferase</fullName>
            <shortName evidence="3">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispD</name>
        <name evidence="5" type="ordered locus">VAB18032_13835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732546.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13835"/>
    <dbReference type="EnsemblBacteria" id="AEB43879">
        <property type="protein sequence ID" value="AEB43879"/>
        <property type="gene ID" value="VAB18032_13835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13835"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049603_0_0_11"/>
    <dbReference type="OMA" id="VNCVNPE"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012115">
        <property type="entry name" value="CDP-ribitol_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036586">
        <property type="entry name" value="CDP-ribitol_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="500" mass="53813" checksum="DF508125B5190E98" modified="2011-06-28" version="1">MTQDQTTDSGTTPQNAAPWRPSRTVAVVLAGGTGTRLGLGIPKQLLKIAGKPIIEHTLAVFEAAPEIDEIIVLMASGHVAEAQQIVTKAGFRKVTKVIEGGDTRNATTRIALDAVGEQDCNILFHDAVRPLLSGRIVRECVNALWTYSAVDVAIPSADTIIQVDENECITDIPVRSTLRRGQTPQAFRSSTIREAYRRAAGDPNFAATDDCGVVLRYLPEVPIKVIDGSDENIKVTHPVDVHLADKLFQLAAAKVPRLADQRTYSDEVAGRTIVVFGGSYGIGHDLTELARRYGAQVFPFSRSSTGTHVERPADVEAALKTAFEATGRIDYVVVTAGILEKGALAEMDQETIDRVLQVNFVGPVTVARQSLPYLQHTKGQLLLYTSSSYTRGRADYALYSATKAALVNLTQALSDEWAELGVRVNVINPERTATPMRTKAFGTEPEHTLLAAEIVAQASLDVLVSELTGQVIDVRRSPGETPTPVVPAQGSRSTSTTPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHA4</accession>
    <name>F4FHA4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13850"/>
    <dbReference type="EnsemblBacteria" id="AEB43882">
        <property type="protein sequence ID" value="AEB43882"/>
        <property type="gene ID" value="VAB18032_13850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13850"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_25_1_11"/>
    <dbReference type="OMA" id="YARMSIE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="22548" checksum="1FB06A3AA3889F91" modified="2011-06-28" version="1">MTTGKRRAPAGAAVLRGEITTAIRRALMQELAAVGYGRLSIEAVARRAGVSKTAIYRRWNSKLDLVLEVVTAAAGARLPALDTGSLRGDLALLFQVVAHALGHPLAAQIIPDLLAEAARNPTIDETLQQVLRARQQEVAGRLITRAVDRGELPATTDPDAAVDLIVGPLYWRLAIARTPVTDSYLETLVDSVLRALGGVDPLPRQRASPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHH9</accession>
    <name>F4FHH9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_20255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733806.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20255"/>
    <dbReference type="EnsemblBacteria" id="AEB45151">
        <property type="protein sequence ID" value="AEB45151"/>
        <property type="gene ID" value="VAB18032_20255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20255"/>
    <dbReference type="eggNOG" id="COG3486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020931_0_0_11"/>
    <dbReference type="OMA" id="FYIRESF"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB45151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="426" mass="47899" checksum="9479BF70122A4DE1" modified="2011-06-28" version="1">MRSYDVIGIGLGPYNLGLACLTAPIAEIDALFLEARDDVSWHPGMLLESSRLQTPFLADLVTLADPTSPFSFLAYLKEIGRLYPFYIRESFFPLRAEYDAYCRWAAAKLPNLRFGHQVSTVEYDPTSEQYVVTATVGGDTVTHRARHLVLGTGTPPYLPEACAGLDSDAVHNSRYLEHRDALRAKRSITIVGSGQSAAEIYHDLLSDIGTYGYQLNWVTRSPRFFPLEYTKLTLEMTSPDYVDYFHALPEQTRYDLEAEQKGLFKGISADLVNDIFDLLYATSVPGPVNTRLLTNTELTGVDHDRSTGRHTLRLRHVEQGREHTLDTEGLVLATGYRYQVPAFCDPIRDRLRFDAHGRLDVARNYSVDHTGRGIFLQNGGTHTHSITSPDLGMGPYRNSWIIRELVGREVYPIEKSITFQEFGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHQ6</accession>
    <name>F4FHQ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735076.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26761"/>
    <dbReference type="EnsemblBacteria" id="AEB46425">
        <property type="protein sequence ID" value="AEB46425"/>
        <property type="gene ID" value="VAB18032_26761"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26761"/>
    <dbReference type="eggNOG" id="ENOG5032YYX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082043_0_0_11"/>
    <dbReference type="OMA" id="RYHLAGC"/>
    <dbReference type="OrthoDB" id="1919338at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="184" mass="18735" checksum="4D36AB1329848A22" modified="2011-06-28" version="1">MIVISLALILVAVALLVLGLASGSSLLLVVSIGASLLAAVALVAGARQAAAARSTTQRDTAGGRSVTIPAQHVPPTTNDGASGWRQPPGPPAGAAPGTNAGTAEAYDDEPPAQEVTPEQAVLVSRLSDEVRVVDGRPRYHLDECAHLVGRDHEPLPVAEAVELGFTPCATCAPDTTLLSQSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F144</accession>
    <name>F4F144_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_07900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731371.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07900"/>
    <dbReference type="EnsemblBacteria" id="AEB42698">
        <property type="protein sequence ID" value="AEB42698"/>
        <property type="gene ID" value="VAB18032_07900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07900"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_11"/>
    <dbReference type="OMA" id="GSLYRIR"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="38"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="311"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="406" mass="41033" checksum="987C3225F50C26BF" modified="2011-06-28" version="1">MAVLSPERAPRLAPARMPPADVVRVGAVGLRTRPLRAFLSALGIAIGIAAMIAVVGISSSSRAELDRTLAALGTNLLTVSPGRTLFGGDAQLPPEAVAMIGRIGPVTQATATGQVAGNVYRTDRIPAAETGGIAVRAAQLGLLETVGAEVASGTWLNEATSRYPAVVLGAAAAERLGLPAAGPDVQVWLGGRWFTVVGVLAPVPLAPELDSSALIGWAVAGSHLDFDGHPTTVYTRTEADQVEAVRAVLGATANPEAPNEVDVSRPSDALAAAQATDETFTALLLGLGAVALLVGGVGVANTMVISVLERRAEIGLRRSLGATRGQIRTQFLAESLLLSALGGTGGVLLGILVTSGYALSQGWPTVVPAWATLGGVAATLVIGGFAGLYPAIRASRLAPTEALAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F196</accession>
    <name>F4F196_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C60 sortase A and B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732599.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14100"/>
    <dbReference type="EnsemblBacteria" id="AEB43932">
        <property type="protein sequence ID" value="AEB43932"/>
        <property type="gene ID" value="VAB18032_14100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14100"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062592_5_1_11"/>
    <dbReference type="OMA" id="NLAGWYE"/>
    <dbReference type="OrthoDB" id="1771853at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="29179" checksum="DBEA4B7167D8110C" modified="2011-06-28" version="1">MFVPPAGDPARRSTGPHPDLFVPQPPTPERPAPPTPERPAPTGHPARGSARPPRLTGYAGKSATTKPARRDTRSGRSPWSLPLAVVLVLLGVFATGAGLGRSVGDPLQWVTAAGGETSTRGVPAAPTAPRPVSLTVAAVDISAAVKPVGDAPDGTIDVPPLSRHEETGWYDRGPVPGEPGPAVIVGHVDTKTGPSVFYDLHKLRVGDTIEVKREDGSVAVFTVNSVERFPKDELPADRIYGHDGPPSLRLITCGGQWVGGPTGYADNVIAFATHTTTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1E3</accession>
    <name>F4F1E3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732646.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14335"/>
    <dbReference type="EnsemblBacteria" id="AEB43979">
        <property type="protein sequence ID" value="AEB43979"/>
        <property type="gene ID" value="VAB18032_14335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14335"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075562_0_0_11"/>
    <dbReference type="OMA" id="VHGSWTT"/>
    <dbReference type="OrthoDB" id="1024950at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="210"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="36003" checksum="E8EA6DBA516A9CB0" modified="2011-06-28" version="1">MNILLWHVHGSWTTSFVHGKHRYLVPATPDRGPYGLGRARTYTWPESATEVSPEQLRDAEVDVVILQRPEELDLATEWLGRRPGRDLPAIYVEHNTPKDGDVPHSRHPMADRDDLLIAHVTAFNELFWDTGATRTTVVDHGIVPPAVEYTGELDRLAVVINEPVRRWRVTGTDLLPRFAEIAPLDVFGMKVAGLADYLGLPADRLMSHDDVPQHRMHAELARRRAYLHLCRWTSLGLSLIEAMSIGMPVVALATTEAAMAVPPDAGALSTRVDTLLAAADRFVAQPQQARRAGLAARAAARERYGLDRFLADWDRLLEEEVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1W5</accession>
    <name>F4F1W5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736344.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03140"/>
    <dbReference type="EnsemblBacteria" id="AEB47712">
        <property type="protein sequence ID" value="AEB47712"/>
        <property type="gene ID" value="VAB18032_03140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03140"/>
    <dbReference type="HOGENOM" id="CLU_2621065_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="78" mass="8513" checksum="B3B21F7883935D23" modified="2011-06-28" version="1">MPKLFDSSLSHHLRYPLWVYAVPVVLFAALPAWILIDGDNLLAAVLVVLGNVQAILLGRILLARNLVAKGKLRAEDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2D2</accession>
    <name>F4F2D2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trans-aconitate 2-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732671.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14460"/>
    <dbReference type="EnsemblBacteria" id="AEB44004">
        <property type="protein sequence ID" value="AEB44004"/>
        <property type="gene ID" value="VAB18032_14460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14460"/>
    <dbReference type="eggNOG" id="COG4106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_5_2_11"/>
    <dbReference type="OMA" id="YLAFADH"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="29149" checksum="FAF2B2A98C0003E7" modified="2011-06-28" version="1">MWDPATYLRYRDERSRPFEDLLARVPAEQPRTVVDLGCGPGTLTATLAARWPDSRIVGLDSSPEMIARAATLDVPVTFEVADLRDWHPEPHTDVLVSNAALQWVPDHRELLTRWAAQLPAGAWMAIQVPGNFAAPSHRALREVAGLAAWRAELAPFQREAPVAEPADYAESLVAAGCAVDAWETTYVHLLEARPDADHPVLTWMEGTALRPVRATLDAAGWSAFRAALGVRLAEAYPVRQGQVYFPFRRIFVVARVDASAQENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2E8</accession>
    <name>F4F2E8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxS</name>
        <name evidence="6" type="ordered locus">VAB18032_14540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732687.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14540"/>
    <dbReference type="EnsemblBacteria" id="AEB44020">
        <property type="protein sequence ID" value="AEB44020"/>
        <property type="gene ID" value="VAB18032_14540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14540"/>
    <dbReference type="eggNOG" id="COG0214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_11"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="784095at2"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="32280" checksum="009B87F0FB1242E4" modified="2011-06-28" version="1">MSETTSPNTSGTTPVVGTARVKRGMAEMLKGGVIMDVVTAEQAKIAEDAGAVAVMALERVPADIRAQGGVSRMSDPDMIDGIINAVSIPVMAKARIGHFVEAQILQALGVDYVDESEVLTPADYANHIDKWAFTVPFVCGATNLGEALRRITEGAAMIRSKGEAGTGDVSNATTHMRKIRQEIRRLSSLPEDELYVAAKELQAPYELVKEVAETGKLPVVLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGNPAQRAAAIVKATTFHDDPDVLAKVSRGLGEAMVGINVDDIPVPHRLADRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2L0</accession>
    <name>F4F2L0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20875"/>
    <dbReference type="EnsemblBacteria" id="AEB45275">
        <property type="protein sequence ID" value="AEB45275"/>
        <property type="gene ID" value="VAB18032_20875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20875"/>
    <dbReference type="eggNOG" id="ENOG5031YPM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2936507_0_0_11"/>
    <dbReference type="OMA" id="WYLTRPR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="6280" checksum="93386FEF51B1DF1B" modified="2011-06-28" version="1">MKDRGIRKLFAVLAGLAVIYFGTTGRSPEEGSGLSGGLVVLALLASLLVWHLTKPGGDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Q8</accession>
    <name>F4F2Q8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733977.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21115"/>
    <dbReference type="EnsemblBacteria" id="AEB45323">
        <property type="protein sequence ID" value="AEB45323"/>
        <property type="gene ID" value="VAB18032_21115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21115"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727438_0_0_11"/>
    <dbReference type="OMA" id="RLGDAHW"/>
    <dbReference type="OrthoDB" id="949624at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="409" mass="45421" checksum="8AAA679DD512BA20" modified="2011-06-28" version="1">MTTVEAGQAATWARPRLRPGIVLGPGTWRDGKLVHHVKDPETGWFYRVGPREHFLMSRMDGTRSLDDLADEYATAYQRRLGPENWQQLFAMLHKRQLLDGATDPDALAALTASAAAGAAKTRRGPLSARLPLFDPQRLFDRVLPWLAPVFSWWFVVPALALALAVAGYVVWHLPELAGGVGGGRPLPAILVAVVVTWLIVFLHECAHGLTCRHFGGRVTEIGVMWRFPLLAPYCKVDDVVLFTPRRRVATAFAGVFVSMLALVPFAALRLWGPPGVLYDLAGTMLLFGTATAAINLVPFLRLDGYYMLSHALNLADLRVDSYRFYGRLLRQGPRAVAGYRIRDRVAFTLYGLTSVLLAGTVLTFLIRYWYTTLANWLTPTWAVVILTTEAVLLATLITHLTRRRPTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Z0</accession>
    <name>F4F2Z0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735251.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46601">
        <property type="protein sequence ID" value="AEB46601"/>
        <property type="gene ID" value="VAB18032_27641"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27641"/>
    <dbReference type="eggNOG" id="ENOG5031S3P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2510717_0_0_11"/>
    <dbReference type="OMA" id="PMAGAIC"/>
    <dbReference type="OrthoDB" id="2056398at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="85" mass="10000" checksum="5DE1B48DDEAC8AE1" modified="2011-06-28" version="1">MLSKEDQRRFEQITRNLRESDPAFFARLDNRARGRRGRWLLLLTILLWAALPAATVAFGRLTGAIFAVVLLTNAVLMWRFRQRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F344</accession>
    <name>F4F344_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_03705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03705"/>
    <dbReference type="EnsemblBacteria" id="AEB47823">
        <property type="protein sequence ID" value="AEB47823"/>
        <property type="gene ID" value="VAB18032_03705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03705"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052605_0_0_11"/>
    <dbReference type="OMA" id="FVAFAID"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029059">
        <property type="entry name" value="AB_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12695">
        <property type="entry name" value="Abhydrolase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313554" evidence="2">
        <location>
            <begin position="35"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="332"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="448" mass="46973" checksum="3FAD56B8657EF807" modified="2011-06-28" version="1">MPTLRGRLTKLAAAGIAAAVGLLTVTVAAGSASAADNPYERGPDPTRTSVATERGPFANTSVSVPTGYGFNGGRIYYPTDTSQGTFGAIAISPGYTALFSAELAWMGPWLASHGFVVIGIETNSRNDFDTARGTQLLAALDYLTQQSPVRDRVDASRLAVAGHSMGGGGALSAATRRPALKAAVGITPFSPSSNLANDRVPTMVISGQADTVVTPSYALDLYNSLPSTTESVYVEVAGGDHGFMVGRSNPVMIRTMLPFLKIFVDNDARYSQFLCPLMDNSGVVTYRSTCPLINTPTTPPPTSPPPTSPPPTSPPPTTPPPGSATQIVGVQSNRCIDVPNSSRNNGTRVQLYDCHGQTNQAWTYTANKQLQVYGNMCLDAAGTGNGAAVQIYSCHGGANQQWNVNSNGTISGVQSGRCLDVWSTSNGAQVQLYDCHGGTNQRFNLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3P5</accession>
    <name>F4F3P5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734000.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21230"/>
    <dbReference type="EnsemblBacteria" id="AEB45346">
        <property type="protein sequence ID" value="AEB45346"/>
        <property type="gene ID" value="VAB18032_21230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21230"/>
    <dbReference type="eggNOG" id="ENOG5033ZG0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1486027_0_0_11"/>
    <dbReference type="OMA" id="LDFVWIK"/>
    <dbReference type="OrthoDB" id="1967254at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045393">
        <property type="entry name" value="DUF6518"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20128">
        <property type="entry name" value="DUF6518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="22137" checksum="1938C7A796880F46" modified="2011-06-28" version="1">MRHHPDRRSIALTAVLGGLLLGILDFIWIKFVPFPFADLGNSSAVWAVAAFAFGFWVRTGWVRAAIGAAVALVVAVPGYYAAAALIQGDEWSILWAPTSLLWMSFGVLAGVVFGIGGVWAHERGWRQPVGIALPGAVLFAEALIDASRINHPNYGIDPLWDVLIKTTLGVLVVVVVARGTRARLLALATALPLALIGFAAFRLAGFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3T9</accession>
    <name>F4F3T9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734043.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21450"/>
    <dbReference type="EnsemblBacteria" id="AEB45390">
        <property type="protein sequence ID" value="AEB45390"/>
        <property type="gene ID" value="VAB18032_21450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21450"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_4_0_11"/>
    <dbReference type="OMA" id="IDICLHP"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="144" mass="15519" checksum="2B5979A46344691C" modified="2011-06-28" version="1">MRIGDIARQAGVSARALRYYEEQGLLTSERSPTGQRIYPASAVERVRLIQLLFTAGLPSRTILALMPHIDTGHGSPEAVELMAAERERISAAIAGLTAARDTLDRMIDIAHHPTSEHCPALREPPWTAYHADAATTAAAVPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3U3</accession>
    <name>F4F3U3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734047.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21470"/>
    <dbReference type="EnsemblBacteria" id="AEB45394">
        <property type="protein sequence ID" value="AEB45394"/>
        <property type="gene ID" value="VAB18032_21470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21470"/>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001338_1_0_11"/>
    <dbReference type="OMA" id="LDEFHTY"/>
    <dbReference type="OrthoDB" id="9107at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="88"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="915"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="2141" mass="236430" checksum="DC1317A109E3BAE3" modified="2011-06-28" version="1">MRPTIAADTLRRTLTQYLTTTFGLTEEGVRHGLEGFLSHPEQGIFRGPYLRIRTPFRSAEGDWRASLDWAPGAFTPYRHQAKAFARLSTRGKAAEPTLITTGTGSGKTESFLIPILDHCRRRRQQGQGGIKAILLYPMNALATDQTHRINEMLTDPALAGVTAGLYIGDVAEIEYLHVFTKRSEMRRTPPDILITNYKMLDLLLQRADDLPLWEGAEPAYVVLDEFHTYDGAQGTDVAMLLRRLSAALGLAEPGRPLGPICPVATSATLGEGGGRDGRTAIREVAEQVFGIAFDADSLVGEERYEPGEFMAGQDFNLPLPSPEQLAAVDGRDPARMMAEIAELVLGEDCLDNPKQLGKLLLRHPLTKAVLDSLGPAPRTFDEIIDVLPRKNATGWGSAMKSRPEITAKALARFVGLLSMARNPHDNRRPLLNIETHLWVRAVSRLLRGTSHQATFGWYGEAPRELDPYATERDAVIADNRHLRLPAVYCRHCGRSGWTALSPEKDPQELETDPDKIYRASVGRDKRRVRALIAATDDEIRQRAAGLLVLEHGRRVRPYDEQRDRALGDDEIAVLGDLTAVDAAEKDRCPSCQLDHGIRFLGAGLATLASVAITQLFTGGELTEAERKTLLFNDSVQDAAHRAGFVANRSYTFSLRSLLADQLTPGEAVGLDDLVTKMVAAAARPEILSTVVPPDLHGQPGVDGLLAGDETGSRQTWSLIGERLVFATVMEAGLRSRQGRTLELTRAVAVEVALDDPAAAVALCRDVQLTGAGQLGVAAPDDASYLAFLRGLLERLRTRGAVYHEWLVPYLRRGGTRWQVWGGRPAGMPAFPRGVSAPAFLLATSKSRSEFDAITARGNWYQDWTARCLGLDLGEAAGYLSRLLPALAAAGIVAAGDTEDGNTVYGLLPGHLRVTRLDDTAAVAAGVGCDTCHWQQTEHPDRVADWVGQPCRQYRCRGRLRPAPDDTTPDDYYRRLYLESPVFRVVTGEHTGMLTRAQRETVEQQFRDGERYTDPNVLSCTPTLEMGIDIGALSAVVLASLPHGPANYVQRAGRAGRRSGNALVLTLVGRTERDRYYLTQPRDMIAGQIVPPGCFLSAVEILRRQYLAHLIDLAARGRLSGVLPMPRRAHVLFGPSGWLAHLAEIGRREGQHLVENFLALFGDRILRAAADELREFAVDGIAHRVKEADERWELRLADLRRRLQEIAAARAKLVTSDPDHARELRMLKAEEAAVRRRLREISAAAAHGTLVEFGLLPNYALIDTRTDLEATLTWEEQVDGDRQFHTELREYARPARAALVEIAPGNSYYVRGYQHEISGLEVGPADRPAYEQWRICGQCGYVRTHLAQEDTSVCPRCADRGIADHGRLFQVLQPTRVYSRDKRDDARIRDDSDDRKRRFYATTAAVDIDPAKVDSSWRHTHETFGVDYTRHAMIRHFNLGAQRFDRAAETFAGEEVRINKFHTCTSCGGTTVDGAPVASQQLAAQASGATVIQGAEHHRPWCPYRRSPAAPDTHVDLILAHELETEALRILIPAATALVAERVVSFAAAIRLGIAAQYGGDPAHLQAVVATMPDGQSDGTRNFVVVFDTQPRGTGYLHRLAEPQEFRRVLELARQRITTCECRLQAKPVCHRCLLRYARNEQFTLMSRDEALGMLDKLLERWNVEEGTRTDEISLIGQVESELEMRFLTKLLALGATPHSGLRVEKRTDHDGARIADLRFVTDGGQNVTHWQMKLQNTVQGTRPDVHFKRLDAPSPEVAVYLDGFKYHASSQYNRLADDAEKRARLRAHGYLVFAATWDDVATWGNAESPGRWLPYGGISRQTARERYRKFLPGADPEEMETTIWTNPIEQLLRFLAEPDLRRWQRRAEAALAGLLPQARENSRCDSSGVADRLLAALRGEPLPPPAAQGKIMVLRARDSADCALTLLVDGRSQPLPTWSALTVLDDLPAAIVADGHKQRWSSWLTWANVIQFLAEGGGDAGQLVVSDLDSFEPASMAVAEGTGLSLTRRALPLDEETSTWLGAVNPLTPTQPVQDGSPWRDVLRYVDPDEGTLEGLVQQLAAWNLPLPVVGYELGDQGWQAELAWPERRVAVVLSGSPGDPEVEDRDRAYTEAGWRVRTAGQWSAEELAAQLAATSGGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4E5</accession>
    <name>F4F4E5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731574.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08925"/>
    <dbReference type="EnsemblBacteria" id="AEB42903">
        <property type="protein sequence ID" value="AEB42903"/>
        <property type="gene ID" value="VAB18032_08925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08925"/>
    <dbReference type="eggNOG" id="ENOG502ZBQ3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088222_0_0_11"/>
    <dbReference type="OMA" id="MIRNAYG"/>
    <dbReference type="OrthoDB" id="1544298at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="26140" checksum="1433ED173F86E379" modified="2011-06-28" version="1">MVSIEGMTEFWDRLVGAQPDPPPLLVLLTGVVALLVVSTRLPWRVARNAITIAHEGGHALAALLTGRKLRGIRLHSDTSGLTLSAGRPTGPGMVLTLLAGYIAPPLVGLGGAWLLAGNRITLLLWLAVILLLAMLVMIRNLFGVLSLLVTGGVVLAVSWYASPQVQAAFAWTSVWFLLLGGVRPVIELQRLRTRRGMPASDADQLAGITGLPAFFWVVLFGLVNLAVLVVGGLMLAGPLLAEAGITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4H1</accession>
    <name>F4F4H1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="4" type="ordered locus">VAB18032_09055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731600.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09055"/>
    <dbReference type="EnsemblBacteria" id="AEB42929">
        <property type="protein sequence ID" value="AEB42929"/>
        <property type="gene ID" value="VAB18032_09055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09055"/>
    <dbReference type="eggNOG" id="COG1722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145918_0_2_11"/>
    <dbReference type="OMA" id="AKVCQRW"/>
    <dbReference type="OrthoDB" id="2057189at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="70" mass="7788" checksum="A326947DFE67C05A" modified="2011-06-28" version="1">MSEQTKDVPLNYEQARAELASVVERLEAGGTSLEESLALWERGEELAVICQRWLDGARARIDATRQDPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4K5</accession>
    <name>F4F4K5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731634.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09225"/>
    <dbReference type="EnsemblBacteria" id="AEB42963">
        <property type="protein sequence ID" value="AEB42963"/>
        <property type="gene ID" value="VAB18032_09225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09225"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_7_2_11"/>
    <dbReference type="OMA" id="HIKAYVV"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24392" checksum="8BE73B0D26C24E62" modified="2011-06-28" version="1">MGEMVTYRGGGGTGEGYLAIPATGTASPAVIVIQDWWGLAPHIRSVVDRFAEAGFVALAPDFRHGEPAGKPSEPQQMLNGPQMDEAAREIAAAAEYLAGRHEVTGKIGCAGFCAGASLALWAGNFSERIVATTAFYPRLPWEGMRSEWTEYAGKDALVHCSEADGTSADPGVQTVRRAIENAGGTCHLHDYPGTAHAFFNEDRPEHFDQRAATSAWARSLELFRAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4U7</accession>
    <name>F4F4U7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734089.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21680"/>
    <dbReference type="EnsemblBacteria" id="AEB45436">
        <property type="protein sequence ID" value="AEB45436"/>
        <property type="gene ID" value="VAB18032_21680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21680"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350184_0_0_11"/>
    <dbReference type="OMA" id="TWGRRAY"/>
    <dbReference type="OrthoDB" id="1790198at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="754" mass="80817" checksum="4A15A97E9C1B25C6" modified="2011-06-28" version="1">MGALAHEVVELRVHGVSGTSAEALLDHPVVTRVAGDDHAGFYRPRPRFGISDRPECLRVEAYRWGALTAGSAVRTLSLLFLLPFMLINLAVWARPPTGGDGGIIGPVCRLIAATLTAAFVLSVVGATVDIVGWQCTPYESCLRGRGYLAWLAELPLGPRLALLALLPVAALRLLWWLGKRSARVFEAFPAARGQDHGEERIDRPGFWDDALVVRRLRVIHVAVGLGTLDVMLLGAKIQRYSHPIAYVLFIAAWGLLAACAVLLVRPARRSEDGSQRGPADLRGIRTLQIAATTLTVLAIAYTAVPQSSQLPQGQLPGYEGAVAALVAVQAALLAVLTAATLAQRRRAHHIASPWLSGLASPVLAAAAVAAAYGFSAALVYRVADFLDRGDIPNPVRPSKPGAPLLEPPVSYRWAALAGLVAVLVVAATIFWQLLATRRRRARMAEAIVRRDFPDVPPEALPRRDDVRTAVARAAIPEQLNPAVIVFLVLSLLGVTTTALDVAGLGPSDLSARFAHTGSAAATALALATDVGMYVIGLIGLGILVLGLLSYRSEGTRRTVAVIWDLGTFWPRTVHPFAPPCYAERAVPELAKRITALTTRGAVILSGHSHGSVLAAATLLQLPADVRSRVALLTHGSPLHRLYARLCPAFLGDPTLYELGSRIGWRWVNLWRDTDPIGGPIFSAHRPGEPPLPGPAGTVDRRLRDPHAVVAAPDDTVPPPIARHWPYHTDRTYEAAVRELADRLNPGQCHPGNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F559</accession>
    <name>F4F559_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735391.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28351"/>
    <dbReference type="EnsemblBacteria" id="AEB46741">
        <property type="protein sequence ID" value="AEB46741"/>
        <property type="gene ID" value="VAB18032_28351"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28351"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_8_1_11"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="119" mass="12393" checksum="DC9D8CE33A204C44" modified="2011-06-28" version="1">MSTDCLFCRIVAGEIPATVVRETPTTLAFRDIDPKAPVHVLVIPKEHYADVATLGQGDPALAGEVLATAAAVAEDEGLLGDGFRLMFNTGPYGGQEVFHAHAHVLGGAPLGPMLARSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F564</accession>
    <name>F4F564_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735396.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28376"/>
    <dbReference type="EnsemblBacteria" id="AEB46746">
        <property type="protein sequence ID" value="AEB46746"/>
        <property type="gene ID" value="VAB18032_28376"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28376"/>
    <dbReference type="eggNOG" id="COG3296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110679_0_0_11"/>
    <dbReference type="OMA" id="WALIAHF"/>
    <dbReference type="OrthoDB" id="2012653at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="19713" checksum="152FE3C51CA16BA4" modified="2011-06-28" version="1">MTEPPRPPSFGDDPTAPVSGSSGQGGYPPPGGYPPPGDQPPSAGYPPPGGYPPPGGYPPPGVGYPTGGYGAPGGGYGTNEDKTWALIAHFGGPLGVVVGGGLLGWVAPLIANMTRGQQSPVVRAHAVAALNFQLTWAVVGLLSWVLTAITCGILFFVPMLVWLVPLIFGIIGGVKANEGVLYRYPMSFSFIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F584</accession>
    <name>F4F584_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012014682.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28476"/>
    <dbReference type="EnsemblBacteria" id="AEB46766">
        <property type="protein sequence ID" value="AEB46766"/>
        <property type="gene ID" value="VAB18032_28476"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28476"/>
    <dbReference type="PATRIC" id="fig|369723.5.peg.3586"/>
    <dbReference type="eggNOG" id="ENOG50333C3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_1_1_11"/>
    <dbReference type="OMA" id="WDKPELD"/>
    <dbReference type="OrthoDB" id="1918103at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="72" mass="7816" checksum="652D1A760631CDF4" modified="2011-06-28" version="1">MTTHPKGDFDLSRAVWQRAEGDTSEAAVEVAFVDDLIGMRNSAEPDGPVLVFTQAEWDAFVAGAQDGEFDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5B5</accession>
    <name>F4F5B5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall hydrolase/autolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736594.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04405"/>
    <dbReference type="EnsemblBacteria" id="AEB47963">
        <property type="protein sequence ID" value="AEB47963"/>
        <property type="gene ID" value="VAB18032_04405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04405"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049583_0_0_11"/>
    <dbReference type="OMA" id="GVATYHY"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="242"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="388" mass="42005" checksum="63782389288AF8CB" modified="2011-06-28" version="1">MRPIRSGDRGPAVAEIRAVLTSLDLLSKATGPYDDEFDTATERAVRAFQQSRGLSVDGRVGAETWRALDAARWRLGARTLYHAVPVPLTGEDVRSLQERLLEMGYDTGRADAIYGIRTSRAVAQFQREVGLTPDGTCGPHTMGALRRLGRKVVGGRPQWLRESDAIRQSGPTLVGRTVVIDPGHGGTEPGVVVPDGPLRWTEADLMHDLASRLEGRLAASGVRVQLTRGPAPETCLPDIDRAHLANSLGADVFISLHTDGHANPAAEGVATYHYGTDNGVTSATGERLAGLVQREIVARTGLRDCRTHAKAWDLLRLTRMPAVRIEVGYLTSPTDRGRLIEPRFRDKLVEAIVAAVQRMYLPDERDVPTGSLDVSELRAAVAAGNVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5N2</accession>
    <name>F4F5N2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_15665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732909.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15665"/>
    <dbReference type="EnsemblBacteria" id="AEB44245">
        <property type="protein sequence ID" value="AEB44245"/>
        <property type="gene ID" value="VAB18032_15665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15665"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046383_0_0_11"/>
    <dbReference type="OMA" id="RRFDRHS"/>
    <dbReference type="OrthoDB" id="195775at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026281">
        <property type="entry name" value="HTH_RamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018653">
        <property type="entry name" value="ScfR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09856">
        <property type="entry name" value="ScfRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019251">
        <property type="entry name" value="Rv0465c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="476" mass="52687" checksum="8154CB1C66B94774" modified="2011-06-28" version="1">MTADKKLYAHAKLRRLRREHGLTQAELARRLDISTSYLNQIENSQRTLTAPILLRLAKVLGVDPEHFADTDAERLGADVRTALADEASGVSVDPVEVVELVRDYPTAARALVALHQRYQDAAGRVAALAGPTGNPPLLGEPHDAVRDFFYEHYNHFDPLDTAAEQLAGYLRLTPARATEVLGRHLREQHDVRVVVTAPTAESRRFDPDSRVLHLAANHTDGQRAFQMATQLAFLEHGNQISELAAGLTSPAAAALARIGLGNYYAGALLMPYTDFHSQAEHLRYDVELLAGHYGVSFETACHRLSTLQRPTRRGVPFSFLRVDRAGNISKRQSATDFHFSRFGGTCPLWIIYEAFAAPGRILTQVAEMPDGKRYFWIARTVTHGGRGHHSPRSTFAVALGCELRHAHRLVYSDGVALDDPRTATPIGLGCRICERRDCAQRARPPAAGHLLIDENRRTVIPYPVDRRQAEPPPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5S9</accession>
    <name>F4F5S9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732956.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15910"/>
    <dbReference type="EnsemblBacteria" id="AEB44292">
        <property type="protein sequence ID" value="AEB44292"/>
        <property type="gene ID" value="VAB18032_15910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15910"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852094_0_0_11"/>
    <dbReference type="OMA" id="HIANLYW"/>
    <dbReference type="OrthoDB" id="1900996at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="31556" checksum="5F38A17D9B5D9B78" modified="2011-06-28" version="1">MVTWLMDGLVGWLAETVTDLLGGLLAFLTSSIFVSPDITVLPQVRSIAGNSALVVNACFAVAVIAAGIAVMLGDGVETQYHVKQLVPRLVVGFILSAFAVPLTGVLISIANALTVAMAGESAPTTEAIGFVRARVASAMTDPGNALLITVIGLLIVVLMFLLVAGWLVRIGLLVILAGIAPVALACYATPWTQGAATLWWRALLGCLATPTVQAVAFSAGINLLVDPESNLPILLGLPASDTLNLLLVVVVLWTTVKIPSLMHRFVTHQGRPPNITALILRTVAVQRMARGLGRPAAALRGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F692</accession>
    <name>F4F692_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_28866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735493.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28866"/>
    <dbReference type="EnsemblBacteria" id="AEB46844">
        <property type="protein sequence ID" value="AEB46844"/>
        <property type="gene ID" value="VAB18032_28866"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28866"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_6_11"/>
    <dbReference type="OMA" id="AVQMPYI"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="75"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="363"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="710" mass="76341" checksum="A853B2BA42155265" modified="2011-06-28" version="1">MSNRPLAAAGRFVPLLRAGLIAGIVVAAVAYPVVALTGVGAKATAHAVESKTRLLATALPAETSYLYAPDGKTVLTMFFEEYRQYTKLSDISPHMQQAIVAAEDNRFYRHHGVDPKGVARAFVANAKSSGVSQGASTLTMQYVRMALRDSASTPKEVQEATAQTPIRKVKEMRMAVDLEKELSKEDILERYLNSAYFGHRAYGIYAASEIFFSKTPKELTPVEAATLAGLVKSPSQYDPASSDQKEATARRNYVLDNMARLGYLSPDSVAAAKTEPIRLRLTYPPNDCASVPEEWNSWGFLCDYLKNWWSAQPAFGDNRLDRLDKLRRGGYRIVLSMDPKIQAAAEENVGTKGNTGSPFANGIVVAEPGTGRVKAMAVNRTYSLQVNENPLSSNPEAGPNVRANYPNTVAPLMGGGDLPGYQAGSTFKMFPMLAALDAGMTLNTTFNAPHSYRSEIYDGWQPSNASGAMSGMQTMWSGFGKSVNTYFVWLEEQVGAERAVRLAEQLGLRWRTDVDREHASPSRANKWGAFTLGVSDATPLEMANAYAAVAADGRYCEAMPVSAIYNRDGTPATFKTPGGIEREVAKPRCRQVVSADAARAATDAARCPTGDTPAKGGCGGWSTADSVRGTVGRPVAGKTGTTDSTRSAWFVGYTPELAAASFISDPDNPFNAVGDGQSEIPIAAVANTLRDALKGKPVRDFIPPSDRIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F695</accession>
    <name>F4F695_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ligB</name>
        <name evidence="12" type="synonym">lig</name>
        <name evidence="17" type="ordered locus">VAB18032_28881</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735496.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28881"/>
    <dbReference type="EnsemblBacteria" id="AEB46847">
        <property type="protein sequence ID" value="AEB46847"/>
        <property type="gene ID" value="VAB18032_28881"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28881"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_1_11"/>
    <dbReference type="OMA" id="WLFEESY"/>
    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 12 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="16">
        <location>
            <begin position="320"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB46847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="538" mass="56037" checksum="6E3443C358FB2881" modified="2011-06-28" version="1">MRFLDLAATSAAVAATSGRRAKVELLAEALRRLDPVEIAAGAGWLAGELRQRQTGVGWAGLRDLPPPAAEPTLTVGAVDAAIDAIAAVHGSGSQARRRALVHSLYAAATADEQRLLTGLFLGELRHGAQAGLLADAIARAAGVPVAAVRRALLLAGDLREVAVAALAGGAAALAGFGLRVGRPLAPMLAQSASSVDEALAATGTPAVVDVKLDGIRIQVHRSGSDIAVFTRSLDDITARVPEVVAAVRALPARELVLDGEAIGLDETGRPLPFQQTSSAAARRGGSAGARSTGGPTAAAPVAPAVRAAAASTGTTVLTPYFFDLLHLDGTDLIDAPGRERWAVLRGTVDAGLLVGRMEVDEPQRAGEAFAAALDAGQEGVVVKAPDAPYEAGRRGAAWIKVKPRHTLDLVVLAVEWGSGRRTGWLSNLHLGARDPRTGEFVMLGKTFKGLTDDLLRWQTERFLGLAVERGDWVVRVRPEQVVEIAFDGVQTSSRYPGGVALRFARVVRYREDKSAAEADTIDTVRAIHAGRPPAAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6J5</accession>
    <name>F4F6J5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16085"/>
    <dbReference type="EnsemblBacteria" id="AEB44323">
        <property type="protein sequence ID" value="AEB44323"/>
        <property type="gene ID" value="VAB18032_16085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16085"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224320_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="25910" checksum="4308BBEEC87B2EEE" modified="2011-06-28" version="1">MEASGWREWPPRLPDQPIFYPVLNRWYATKIAREWNVPAGGVGYVTRFEVQREYMDRYEVHQVGGRDVLEYWIPAEELADFNAHLVGAITEEADYRGPVGDQEFTDAHHALGRALPAAWRTYLQGASWFRRGWMTGEAYVWLNTPREMLELHHAWHESTDLHPGIAIIGGDGSREQLVLDLRSDPAPVLLVDITSSGWDNAIRQADDVDELINRIEAGTFDFDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6N8</accession>
    <name>F4F6N8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily mfs_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_16300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733026.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16300"/>
    <dbReference type="EnsemblBacteria" id="AEB44366">
        <property type="protein sequence ID" value="AEB44366"/>
        <property type="gene ID" value="VAB18032_16300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16300"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_6_0_11"/>
    <dbReference type="OMA" id="LPMAEWF"/>
    <dbReference type="OrthoDB" id="1249292at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="239"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="447" mass="47099" checksum="08FC8E880364BF0B" modified="2011-06-28" version="1">MTALRGAAGEVRTRAGDLTAYATGSVGMGVWVTVPGLLLLYFLTNTLGVSPFLAGLTLLLPKIIDIIVHPMLGSRSDREARSSGHRLGMLRVGLLLPVAMVAMFSVPAGLSGASAALWVGGWFIAGNLLFACFQVPYLTTPSDLRVGYHERTRVFMFRMLFLTLGLLGAGVAAPALVESGRRGDYGWMALLLSGVMVISGLVALTGVRRLTAHAGFRMPDQKAAHSTIGDIAVAWRDPDFRALVLSYLFTGTTTHLFLAALPFYTRYVFENSGLTAVFMGAFLGPAVIAGPVWMQVSRRIGKQRGLLICQAVFVAGSLAPLLGYGTGPAVAVVGVLGIAFAGLQLFAFSMVPDAVAAAEQRGTVRAGAYTGVWTATEATGTAIGPYVYSAVLALGGFISTTEGQTVTQPESAHTALLIGFTVVPAVLMAAALTFQVRWKLDRTRHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Q6</accession>
    <name>F4F6Q6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">ATP-binding ABC peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">abyF4</name>
        <name evidence="7" type="ordered locus">VAB18032_16390</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733044.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16390"/>
    <dbReference type="EnsemblBacteria" id="AEB44384">
        <property type="protein sequence ID" value="AEB44384"/>
        <property type="gene ID" value="VAB18032_16390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16390"/>
    <dbReference type="eggNOG" id="COG4172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_2_11"/>
    <dbReference type="OMA" id="VTHRVHA"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="8"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="288"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="325"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEK75511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="539" mass="57485" checksum="A50CF2CF1F40DEEC" modified="2011-06-28" version="1">MDDEVVSVAGLHVTYRVGRAEVFAVRGVDFHLRAGECLAIVGESGSGKSTVARALVGLTGPGARLRSDRLVVSGQELSRLGDREWRRIRGAQVGLVLQDALTALDPLRTVGAEVAEAARNHGLVRRGEVARRVHRLLTDVQVPQPELRARQYPQQLSGGLRQRALIAAAMAADPPVLVADEPTTALDVTLQAKLLDLLAARKAAGTAVLLISHDLSVVARLADRVAVMRDGEFVETGCTTDVLRAPEHPYTRQLLAATPSAHARGARLAGPRSTPARTRTPRPSGVLARVREVSKTFRGPGGARLAAVSEVSFSLSAGEILGVVGESGSGKSTLAHLLLGLLEPDTGTIELFGQPWSGVPEARRQRGRVQWVQQDPLGSFDPRYRVGRLIAEAGVDRARVRELLDQVGLDPAMADRHPRTLSGGQRQRVAIARALARDPEVIVCDEPVSALDVSVQAQILDLFADIRADLGTALVLISHDLAVVHHVADRVLVMRAGTVVESGPVTEVFARPTHPYTAQLIAALPRPGDAYAAYPEGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F709</accession>
    <name>F4F709_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29011"/>
    <dbReference type="EnsemblBacteria" id="AEB46873">
        <property type="protein sequence ID" value="AEB46873"/>
        <property type="gene ID" value="VAB18032_29011"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29011"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_1_11"/>
    <dbReference type="OMA" id="WFVEKFH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="386" mass="43018" checksum="CB4623B5E6CA9EC0" modified="2011-06-28" version="1">MVPYRIEIPQEALDDLDRRLAATRWPAEMPGVGWERGVPADYLRELVEYWRTSYDWRATEAELNRLPQFTTEIDGANIHYVHVRSPEPDATPMIITHGWPGSFVEYLDVIGPLTDPRAHGGNPEDAFHLVIPTLPGFGLSGPLREPGWSMPRVAGAWAQLMARLGYDRYVAQGGDFGSWVTVMLAGMDHEHVLGGHLNFLPTPPSDDPADMAALTEVELGRLSKLGRFATEQAGYMHIQSTRPQTLGYGLTDSPVGQLAWIVEKFKDWTDSAKVPEDAVDRDRMLTNVMLYWLTSTGASSAHFYYENAALLPIATTPPPPPPPLPTPFGIAVFQHDPGQPIRRFAERGLPNIVQWSEYDRGGHFPAMEVPDLFVGDLRAFAATIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F711</accession>
    <name>F4F711_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735524.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29021"/>
    <dbReference type="EnsemblBacteria" id="AEB46875">
        <property type="protein sequence ID" value="AEB46875"/>
        <property type="gene ID" value="VAB18032_29021"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29021"/>
    <dbReference type="eggNOG" id="COG4312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066898_1_0_11"/>
    <dbReference type="OMA" id="ETGIWWR"/>
    <dbReference type="OrthoDB" id="1567592at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="27169" checksum="DA20BA2135EBCA1E" modified="2011-06-28" version="1">MGLPTVVDREEWLVARKALLATEAAANEARRAATAERQRLPMVRVDKKYVFEGPQGTVSLADMFEGRRQLIVYHMMFDPAWEEGCRFCSLLMDNVGHPAHLHARNTTFAIVSRAPLAKLLRHRERMGWPLPWYSSFDSDFNYDFHVTLDEAVAPVEYNYKDKATLLAEGMDFFTEGEQGAVSVFLRDGEDVFHTYSSYGWENDILHNTFNYLDLTPLGRQMEGPGSVTIRLHDRYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F722</accession>
    <name>F4F722_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug ABC transporter ATPase/permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_29076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735535.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29076"/>
    <dbReference type="EnsemblBacteria" id="AEB46886">
        <property type="protein sequence ID" value="AEB46886"/>
        <property type="gene ID" value="VAB18032_29076"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29076"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="QDFNRYE"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="361"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="395"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="616" mass="65835" checksum="574F40AA7FB6C3C2" modified="2011-06-28" version="1">MSWLARRAAERWEIVKLFRHAGAGLIAALAAVNLVLGVLPVVFVIATSIMLGKVPGAVEAGLDSPEWASLVQTFLIGAAAFVGQQLLAPVVALLRELAARRVDGALFRTLMEASLRSPGIGPLEDRDTLDDLRNAARELEFGFQSPGQAVPGLLALLARYTSLAGYAVVVGVVFSWLAAAGLVTVVLLFRHGQRGGLRRYAKVRFAAAGASRRLDYVRGLAVDSTAGKEIRVFGLIGWLREQLADAYAQLLGPVRAARRRVYLWPFVWFAVWGVLVTGALFAGLGASAADGITLTAFVLVVQSSLGALRLSEYYGEADSQTCIGIYGYRALQKFTARIDATAPVDAQPTAAPPAPEPVSEIRFQDVTFRYPGQDRPTLSGLNLTIPVGRCTALVGVNGAGKTTIVKLLARLYEPDSGAILVDGVDIRTYTVDQWRARLGIIFQDFARFEASAADNIAFGAVAAQSDRDGVRRAAAAVGLGELLAELPQGEDTPLARHLTGGVDLSGGQWQRVALARALFALHHGAPVVILDEPTASLDVRAEAQFFDEFADLTQGATTLLISHRFSSVRRADNIVVLADGDVVEQGTHEELMAAGGRYHQLFSLQADRFATAEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F778</accession>
    <name>F4F778_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10090"/>
    <dbReference type="EnsemblBacteria" id="AEB43136">
        <property type="protein sequence ID" value="AEB43136"/>
        <property type="gene ID" value="VAB18032_10090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10090"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392282_0_0_11"/>
    <dbReference type="OMA" id="RFREPRY"/>
    <dbReference type="OrthoDB" id="1987791at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="703" mass="77225" checksum="6EC2D8E92B6CE7D0" modified="2011-06-28" version="1">MPATLLPGEALDEAGAVDATPRAMAGSATGIAVHGDYTLINLSQPDGRKASVHRWVRDPAILEETARTYVEVTDFTQMAARLPEHRVILLGGKVGTGRRTTAEMLLWQVAGIDRVAGVEPVHADVTAAELAGTDNLLLRGYGTVLELPPNAKVTIGTLRAFERLARDHKAHLVILHDRTDPPGPELMPYGAAYLPPSTENVLRRHLLRMLAREQRCVGDCPNCHGGCRTAFVDRCLANGQVQAELAADPRPVQIVGLATALAGWSGVDSDLGAALGGLLSRRRAFVARLLKTANSPRQDEKEEDPQAAPRRQAFQIAYAAFDEHPLADVFDAAELLLTILRAVEVGTEHQTRVVFDGGVEQMLRAPDGEGQFTAAEVLEQPRRARLAHPELLTDVLDVVWHDFDGGRRPLLHWLEQLVISGRDAVRQRAAYLAGWLARYDFDEVWAVLIRNWAADERGTIRQAAAWALHIAATDKTLLARIRVRVRNWVRSGSPRLHDTAARAYGTLLGLAVAEESLAELRTLASRDDLNNSAAVARTLITLYDPPEPYQNAAAPAATWRTLVTWHGENLYRLRVHATRGFLLLARRNGVPPYDGWPLLLTSTAGFTPAGHELVALWQTTLTDPTTAHRAWLELRTWLRLADDDPDLAGRVQDLVCRILVGPVAVRGRFYLHSWRSQSSTAGRLLGMPWGVPTETTRQQGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7E2</accession>
    <name>F4F7E2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-formimino-L-glutamate deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731871.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10410"/>
    <dbReference type="EnsemblBacteria" id="AEB43200">
        <property type="protein sequence ID" value="AEB43200"/>
        <property type="gene ID" value="VAB18032_10410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10410"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_3_1_11"/>
    <dbReference type="OMA" id="MCPTTER"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02022">
        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="62"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="452" mass="47456" checksum="35949F5515B47284" modified="2011-06-28" version="1">MTSTRWLAEYAWLPERAAPTPEVLIETVNGRITAVTPLSPGGPPDAGVDVLADAVWLPGLTLPGLANAHSHAFHRALRGHTHGGRGDFWSWRDQMYAVTARLNPDSYLALARAVYAEMALAGITCVGEFHYLHHGAGGTPYDDPNAMSAALVEAAAHAGIRLTLLDTCYLTATVDGQPLTGSQLRFGDGDALRWADRVSAFTPDGRHARLGAAIHSVRAVPAEQLATVAGWAHRRDAPLHVHLSEQPAENDACRAVHGRTPTGLLADHGVLGPATTAVHATHPTSGDIGLLGESRSGVCLCPTTERDLADGIGPARRMAEAGIPLSLGSDSHAVIDPFEEARAVELDERLRTRKRGHFAPAELLHAASAAGHAALGWTDAGRIAVGGRADLVTVRLDSVRTAGVAPAGVWFAAGAADVTQVVVDGRVLVRDGHHLTVDVPQELADAIAEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7E3</accession>
    <name>F4F7E3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoate amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731872.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10415"/>
    <dbReference type="EnsemblBacteria" id="AEB43201">
        <property type="protein sequence ID" value="AEB43201"/>
        <property type="gene ID" value="VAB18032_10415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10415"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024588_6_0_11"/>
    <dbReference type="OMA" id="IWPHGRW"/>
    <dbReference type="OrthoDB" id="829830at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="406" mass="43230" checksum="619EA36B2ADFE70D" modified="2011-06-28" version="1">MLTHTVEEGPLLNRFRRLWDEIAPIGRDGRSGGYLRYALTEPELRLREWFRTQADERGMPVTEDGNGNLFAWWGDPDAGDAVLTGSHFDSVPHGGAYDGPLGIVSAWLAVDELRAAGVTPSRPLVVAAFVEEEGARFGVPCLGSRLLTGQIDVERAGALRDAAGVSFAEALGARPAGGVPALLGRFGAFVELHVEQGRALVEQDAPVAVATAIWPHGRWRFDVTGEGNHAGTTRMADRRDPMLTYAFTVLAANKEARLRDAHATVGRVAVEPNATNAIPSRVTGWLDARAAEPETLTGLVEAVRTKAVERARRDGTEITLTEESATPLVAFDNGLTDRLARLLDAPVLPTGAGHDAGVLAAHVPTAMLFVRNPTGVSHSPAESADDVDCAAGVIALARVLEELACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7V1</accession>
    <name>F4F7V1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine pyrophosphate central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734390.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23190"/>
    <dbReference type="EnsemblBacteria" id="AEB45738">
        <property type="protein sequence ID" value="AEB45738"/>
        <property type="gene ID" value="VAB18032_23190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23190"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639256_0_0_11"/>
    <dbReference type="OMA" id="ASMAIGH"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="429" mass="43945" checksum="D5CFF67C29C075CE" modified="2011-06-28" version="1">MPDPRLAQTAVPDPYPAETAIPDPHLAETVVARLAAWRVPRVFGIAGEPVAALVEALHSAGGEPEFVPVRHGESAASMAIGHARLTGGVGVCLSPAGPAAFGLLAGLDAARRATLPVLAIIDGVDGVSGGDGAGGVDQMLAGLCRQVWHLDDLRRVPALVDAAVRGALAGHGPACLLLPGTSGRPSALAEVSAESVAVDPGRPPAVPQVGAGMVFVESTRPLAAPDAGTVFVDSVPPSVVPEVDAEPDFTESGRPSAVAGVDIGLVVDELSARVPPEAAVTMDGAPGLSRHASRLPPGIAVLACDAHEVSGAALPYAVAVKLVDPQRPVLALLTDDGMRSHGLSELVTIARDWPHWPDPRLVVLVLNTRAGYPGRQVADDVPYAGWARLLGLRGVRVDRPELVGPAWDEALAADRPCLLDLIVTPHSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F806</accession>
    <name>F4F806_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735629.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29551"/>
    <dbReference type="EnsemblBacteria" id="AEB46981">
        <property type="protein sequence ID" value="AEB46981"/>
        <property type="gene ID" value="VAB18032_29551"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29551"/>
    <dbReference type="eggNOG" id="ENOG503311A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147945_1_0_11"/>
    <dbReference type="OMA" id="FWDVKNP"/>
    <dbReference type="OrthoDB" id="1964416at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12023" checksum="1509A1A328334F3B" modified="2011-06-28" version="1">MATIDLTPDSIRIRLTPAEKLWALRGDVTVPRSAVTAVTVQPDGLRAPRGIRAPGLGLPGARKVGTWRGRAGKEFVSVRANQPAVRITLTGQRYDALVIGADDATAVAEAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8A4</accession>
    <name>F4F8A4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Group 1 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731936.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10735"/>
    <dbReference type="EnsemblBacteria" id="AEB43265">
        <property type="protein sequence ID" value="AEB43265"/>
        <property type="gene ID" value="VAB18032_10735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10735"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_11"/>
    <dbReference type="OMA" id="DLIIAHT"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="381" mass="41593" checksum="A830F3203AC18366" modified="2011-06-28" version="1">MPDRNYDLTIASPFYEPYVSGLTQTARSIAEGMANRGWRVAVVTAQHEVDLPLRDAVGGVDVYRSPMLTRSSRTAIVPRYPMLVGQLARQSSVLHLNLPMPAAALLMPLASRVPVVSMLHSDPHLPPSWFGRAVAYASDAAARSAIRRSAAVVAASRDQAYASRFWPVIRDRTFTPIAPPCLDRRGGEPRYRETRGLHVGFLGRIVADKGIAYLVRAFHRIADPDARLLIAGNYHTVAGGSNLAAVQAEIDRDSRVRILGELRGREVNDFYASVDVFALPAVAGSFGTVLAEAMMSGIPSVTTDLPGNRYPVTATGFGRVVPPRDPRALEQAISELAAVPRDWRERKARAARARFSVATSLDAHEVLFSTLRGRTAARQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8B6</accession>
    <name>F4F8B6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731948.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10795"/>
    <dbReference type="EnsemblBacteria" id="AEB43277">
        <property type="protein sequence ID" value="AEB43277"/>
        <property type="gene ID" value="VAB18032_10795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10795"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="AGLYPWR"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="270" mass="29889" checksum="E89891A43A019F4C" modified="2011-06-28" version="1">MPDRSTLLRVEHLRKVYESATGNVEAIGDISFTMNAGELVCIVGPSGCGKTTLLKCLAGLLRPTSGVVEMDGAPVTGPSPAMAVVFQEYGRSLYPWLTVRGNVELPLRHKKLSRAQREKLVTDALVAVGLDHAARSHPWQLSGGMQQRVAIARAIAYQPEVMIMDEPFAAVDAQTRADLEDLVRELHTSRNMSILFVTHDIDESVYLGERVLVLSKSPTWVQEDLAIDLPPTRDQITTRALPRFTELRTHVYDQIQRAKRGKTVDAQPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8E4</accession>
    <name>F4F8E4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733144.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16925"/>
    <dbReference type="EnsemblBacteria" id="AEB44489">
        <property type="protein sequence ID" value="AEB44489"/>
        <property type="gene ID" value="VAB18032_16925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16925"/>
    <dbReference type="HOGENOM" id="CLU_1758064_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="148" mass="16083" checksum="F133A64A009D67BE" modified="2011-06-28" version="1">MRPIVIRPRIQIPVLVVLSAVWALLGVTYFTSGDVVAERDWFGIVLGSLLLASGMAGVWRALRLGVVVDAAGVRVRNFASRDQIIPWNSLQSIDCLQVDVRAGIPLYAPVLHFHSDVDAVPLPTLGSYSRHAVERTVDELRSLANGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8K2</accession>
    <name>F4F8K2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_23235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734397.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23235"/>
    <dbReference type="EnsemblBacteria" id="AEB45745">
        <property type="protein sequence ID" value="AEB45745"/>
        <property type="gene ID" value="VAB18032_23235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23235"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_43_2_11"/>
    <dbReference type="OMA" id="GYDLTEP"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="20183" checksum="5BC2C8988CF88B9F" modified="2011-06-28" version="1">MARLGLTPQRLAAEGAELADEVGFDQVTASALAQRCGVKVASLYAHIRSTQDLKVRIALFALNELADRATEAVAGRAGKDALVALGNVYRDYAREHPGRYAASQLRLDPATAAGSAGPRHSQLARAVLRGYRLGEPEQTHAVRLLGSVFHGFASLDLGGAFSHSVPDSEESWSWTLNALDTLLSSRSTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8M9</accession>
    <name>F4F8M9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23370"/>
    <dbReference type="EnsemblBacteria" id="AEB45772">
        <property type="protein sequence ID" value="AEB45772"/>
        <property type="gene ID" value="VAB18032_23370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23370"/>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047692_0_0_11"/>
    <dbReference type="OMA" id="CEQFLVP"/>
    <dbReference type="OrthoDB" id="912462at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="498" mass="54811" checksum="4DDA9C083BFAAFAC" modified="2011-06-28" version="1">MAIPDLRHPAPPGTPSTRPELPGTDLPAEPGGDLRAEPGSFRDPANRVFHAGQDVLRALDETAAAHWRALAGSDFFPPLMAAGKVCGTEEMPAATAPERWAAVLRHDRIPFVSHPYEWSFTMLRDAALLHLEILREALPAGFTTKDGSAYNLQWRGTEPVFIDVGSFAPLREGEPWAGYRQFCQTLLYPLLLNAHLGVDFRPWLRSQVDGIEPDQMGRLFRGVRRLLPGVLTHVHLHGSVQRRNAARTTTDVRAQLRDAGYSRELALATVRGMEKLVRRLDHQPPTSHWVDYQRTCGYSEADRSTKERFVTAALTSATQRRLVLDLGANDGRYARLAAAHADYVVAVEQDPAVVDRLYRALRGEGERRVLPLVMDLADPSPGGGWRGIERASFAARTGADTVLALALVHHLAIGRNVPLPEVLACLTALAAPGGRLVVEFVHPEDPMARRLLANKPDGLFPDYRRDAFEALLAARGTVEDRLELPSGSRTLYRVALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8P9</accession>
    <name>F4F8P9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734444.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23470"/>
    <dbReference type="EnsemblBacteria" id="AEB45792">
        <property type="protein sequence ID" value="AEB45792"/>
        <property type="gene ID" value="VAB18032_23470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23470"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_7_3_11"/>
    <dbReference type="OMA" id="VLDVPGW"/>
    <dbReference type="OrthoDB" id="1834577at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="240" mass="26573" checksum="D39190E09ECD36BF" modified="2011-06-28" version="1">MRWQPARLVSRRVETATAQTLVLEVPDWPGHLPGQHVDIRLTAPDGYQAARSYSLAGPADGDRIEVTVQRVPDGEVSPFLVDGYQVGDPVEVRGPLGGWFIWRPQQTEPVLLVAGGSGVVPLMAMIRARRAAGSRVPFRLIYSVRTPDDVFYAEELRQRVRDDAGLDVAYVYTREAPEQWPDRPHRIGLADVNTHGWPPELEPRVYVCGPTGFVETVADLLVGLGHPARLVRTERFGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9A3</accession>
    <name>F4F9A3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10895"/>
    <dbReference type="EnsemblBacteria" id="AEB43297">
        <property type="protein sequence ID" value="AEB43297"/>
        <property type="gene ID" value="VAB18032_10895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10895"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083296_0_0_11"/>
    <dbReference type="OMA" id="TEIGKCM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="86"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="24263" checksum="7FC88594BB9BA3CB" modified="2011-06-28" version="1">MTSTVRLDDLIQTIKQTHTDALDQLAGAVLVADHIGEVADHLIGHFVDQARRSGASWTEIGRSMGVSKQAAQKRFVAGTMDPQEGFQRFTPRARNVVAAAHNEAKAAGSAHTTPAHLVLGLLAEPEALAAKALAAAGVSAEAVREAATAALPPAADEAPDLIPYDAASKKALELTFREALRLGHNYIGTEHILLALLEQEDGDGVLTGLGVTKAATEANIVATLDKLRVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9J9</accession>
    <name>F4F9J9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KAP NTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733232.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17375"/>
    <dbReference type="EnsemblBacteria" id="AEB44577">
        <property type="protein sequence ID" value="AEB44577"/>
        <property type="gene ID" value="VAB18032_17375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17375"/>
    <dbReference type="eggNOG" id="COG4928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879820_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KAP NTPase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="316" mass="34402" checksum="6B5C821B456A40CB" modified="2011-06-28" version="1">MDFGGHDIGEVIGDLSRAGYELVVFVDDIDRCRPGTAAEVFEAINLFLSGVTTRQGLRARFVVALDPEIIAAHLDNVYAALGGSGVARYGDDPSPGWAFLRKLVQLPVVLPQIPEPAVGEFVDRITAPAPRPASVPPTAAPPVPAPRSKPAVELRGTRSAPVPPAAIPVETVPWRTIERHPEVSSLIARRLAAQPNRSLREAKRLLNVWQLYERLLASGEPVPPDQAIRRARHLVLVAEIVTRWPALQRPLHRYLDPTARGLDLLAKTAAADAAWAEAVERLGIDVDVHAHALAGLRQLLRDHCDAELLKLTRALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9K4</accession>
    <name>F4F9K4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733237.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17400"/>
    <dbReference type="EnsemblBacteria" id="AEB44582">
        <property type="protein sequence ID" value="AEB44582"/>
        <property type="gene ID" value="VAB18032_17400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17400"/>
    <dbReference type="eggNOG" id="ENOG5030GV3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896632_0_0_11"/>
    <dbReference type="OMA" id="LLHLWMP"/>
    <dbReference type="OrthoDB" id="1196806at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="318" mass="35050" checksum="094D327C50355BA7" modified="2011-06-28" version="1">MITFGEVHTNLLQHSTALVQEQSSEVLSLVEGEAVLTSRRPSLYAVSPDVRTGVDCWLPSARRRRLRGVGAVVTRAIITGGRIVQASSVIQVVAGERRQPWSHYLANPGVLETVGKLDSADLTSGFLHGNDADVLNLEAITGRVLDGVQMSDLLDRRPPLRAARTRLRWTAQVGQQPDREVSAIVTVDSPTLRTVELVLAPQDVPAAVAGLCEDLALHDWLLTTLSSLMEAVVTRSGNGQEHVERLRPVLEHLLHLWLPGARVDPRLRPIWDRLEQVPGFSRQWNSSVNWIRDQISVGNLALLRDLASRMSVDQPCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9K5</accession>
    <name>F4F9K5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTPase (NACHT family)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17405"/>
    <dbReference type="EnsemblBacteria" id="AEB44583">
        <property type="protein sequence ID" value="AEB44583"/>
        <property type="gene ID" value="VAB18032_17405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17405"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255435_0_0_11"/>
    <dbReference type="OMA" id="QSDQDSW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="252"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1383" mass="153811" checksum="A7D321D584F86186" modified="2011-06-28" version="1">MARRLEIEDVAMEAYGADVRPPLDRCLADVRRCDLYIGLFAWRYGFRPPGQESSITELEYREALAAGKPCLVFLLAEETPWPVDQVDRGADGERIVELRRELKERHLCAFFTSVDDLTAKVTAALADVRSGRSPARGPADPDTHLPEAVRSHYHKQLALRYQAVPVDAVSPRPTIGYLTVGLPKLFVEPRVHEEARPEMPLAWWRWAGTTSDGDTSGLPGVVNPEELERLWEEYAAKDALSLFDVVCDPGRRTIVLLGDPGSGKSAAAQYLALALAGACDEPRLAALNQYLPVLIELRSYAAHRGDGRCDGLLDYVGHRHQQGLTGIDQEVLESYLRQGGQALFLFDGLDEVFDPAQREEVAAQIATFANEYPGVLSVVTSRAAGYQRHTFANAGFDHFTLEDLDDEQITQFLDNWYRYVMPTPAVEAQRQRRQLLDMLRNSRAMHEIAGNPLLLMLMTIVGRSHPLPRNRRRLYAHVTDVLISEWDVTKQLRESHGDVPSLDLQAKRRLLRHLAFHMQFRESGPAGNYIDSDELGRVFRDHLVAFYGFENERALAMAYSMIEKLRHRSFILERYGLRLFGFVHRAFLEFFCAEEIVDRFENDPGAWDLDRLRALFREHWADPSWREVLRLVAGALPARIANELITLLATETTQPWPPLNLTAPPWNLVLAAQCVAETPQPAELTAAGNAVLCQIVLLVEHGISADDPNLTELTEQELLSSVRALGPNWPGRHTFLNWYRRRGVRTSWRSGSTFATRIAAALSTTEEHLEELLVRELQHGRERQAHLALVAGLAEAAGRLNATDGDRHRYRDILITQARAEVSTAVRQAAVRALITHFGADADLIHELRDLTDSPDPAIRALAVQSLGGRAELSDNIRHVLLRATEDNTTTVRRAAVAVLTARGTDLPDAPGTLQRLLATDSDPAVVQEALTALLALPEHAETARSRALQRMTGDSPDEVRRCLVTRLLPGRAGPEQTELLLKLAGSDSSARLRATAVQRLTLVPDPDGRCRARLIDQIEQDEDASVRAAAVTALIDRDSTDDACWTVVARAARADEDATVRLAAVRALAETHPDPRTEELLLASARRDPTASVRLAAVDLLTGRQLFGRATRDLLISRAFEERDALVRLRVTRSLARLADPPDPAVRECLAEQVSRDPDPNVLRAAADALARHGETDSLVETLCRRARRDSYVGIRLAAVRTLCRYGSPDVVTDTLLECVESDTDPTVFDAAVCCLTEQGSASMAVTLRLMRRLSDQDPAIRARIAAALGEHFGTDPEVQVLLVGLVRDDPALEVRRRAVEQLGATLAGRAGVPELLLRLAADNDWEIRRTALLALTRHHYRDTRTRELLIRLGRERDDDTVQRLAGQLLATLPDITPDDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9M0</accession>
    <name>F4F9M0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733253.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17480"/>
    <dbReference type="EnsemblBacteria" id="AEB44598">
        <property type="protein sequence ID" value="AEB44598"/>
        <property type="gene ID" value="VAB18032_17480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17480"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="KGLCKNY"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="32771" checksum="0B2373C96EBDC12A" modified="2011-06-28" version="1">MTTAIDIRHVDKSFGRVRALDGLDLRVATGTVHGFLGPNGAGKSTTIRILLGLLRADAGQVRLLGGDPWADAVTLHRRLAYVPGDVELWPNLTGGEAIDLFARLRGGTDPVRRDELCQRFDLDPSKKGRTYSKGNRQKVALVAALASDVELLLLDEPTAGLDPLMEAVFQECIREAKDAGRTVLLSSHILAQVEVLADQVSIIRQGAIVETGSLSDLRHLTRTTVDAITDRPIDALAGAAGVHGLRAENGHIRFEVDGDHLAAVVRQLGDLDVQGLTVRPPTLEQLLLRHYGDQFTRSGATEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9R0</accession>
    <name>F4F9R0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_23690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734488.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23690"/>
    <dbReference type="EnsemblBacteria" id="AEB45836">
        <property type="protein sequence ID" value="AEB45836"/>
        <property type="gene ID" value="VAB18032_23690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23690"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039404_3_1_11"/>
    <dbReference type="OMA" id="GDRRSHM"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309181" evidence="5">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="52"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="242"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="420" mass="44994" checksum="E2043BCED167B48F" modified="2011-06-28" version="1">MRFRRRLTLFAVTVAAAPLALGACTSDRRPGQQHAETRAKPEVTVTPAEGSRDVPISGEIGTDVKHGRVTAVRITDDKGATVEAEPREDGTGWVPSKPLAPKRTYTAEVTVTGDSGDTVTRKTTFTTQPKSSKPAISSVLYFAGNRTYGTAMPVTVAFDPPIPKEARADVQRRLFVKTDPPQPGTWSWVSDGSQVYYRAPDFWRPGTTISVRSALEGLPIGKEHVGDTDKRATSKIGRQVQLEIDNATKRMSVFQDGKLLRKLPVSLGKPSTPTSSGKMVIMEKHDFTTFDTRGSADPYVVDVEDAQRLTWRGEFIHGAPWSEGDQGYTNVSHGCTNLSAANADWLMGVTQVGDLVTVKGTEVPLDEGNGWTAWNVSWEQFAKGSALPVPAGLQPTPTQAPDPGAVAGGSPEPAPSASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA55</accession>
    <name>F4FA55_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730790.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04950"/>
    <dbReference type="EnsemblBacteria" id="AEB42116">
        <property type="protein sequence ID" value="AEB42116"/>
        <property type="gene ID" value="VAB18032_04950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04950"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_3_11"/>
    <dbReference type="OMA" id="SGWWRDP"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="180" mass="18769" checksum="4E988F895B979E64" modified="2011-06-28" version="1">MSAELSKRLVELFRWVDPGPDASHLVSDVSGWWRDPTVLAELGPALVAPFRAARPTVVVAPAVTGFLLGPLAATALGVGFVPAHKPGDGRLPAGPLTWAQSPSDFRGRRVDLAVQSRHLSAGDRVLVVDDWVATAAQVQALYDICASLGAEPVGTSAVVVDCPPSVATTLRIHALTTLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA59</accession>
    <name>F4FA59_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_04970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730794.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04970"/>
    <dbReference type="EnsemblBacteria" id="AEB42120">
        <property type="protein sequence ID" value="AEB42120"/>
        <property type="gene ID" value="VAB18032_04970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04970"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_12_1_11"/>
    <dbReference type="OMA" id="IEFARMM"/>
    <dbReference type="OrthoDB" id="357522at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVRC" evidence="6">
        <location>
            <begin position="433"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="618" mass="68153" checksum="FA58CF548F213608" modified="2011-06-28" version="1">MTHYKSNLRDLEFNLFEVFGADRAFGQEPYTDLDVDTARTFLAEMDRLAREDLAASYTDSDRNPPVFDPATHTAPLPESFKKSYQAFMDSEFWRLDLPAELDGSNAPRMLWWALAELVLGSNAPIWMYASGPSFAHVLRVEGTERQKKWAKLFVDKQWGSTMVLTEPDAGSDVGAGRARAIPQPDGSWHIEGVKRFITSGEHDLSDNIVHYVLARPVGVEGVGGPGTKGLSLFVVPKYHFDEETGELGERNGVYATNVEHKMGLKVSNTCELTFGEHGVPAKGWLMGDKHDGIRQMFMIIEYARMLVGTKAIATLSTGYLNALEYAKNRVQGADLLQSTDKTAPRVTITHHPDVRRSLLLQKSYAEGLRALVCYTASWQDKVAIAEAAGDEKATKLAKRVNDLLLPLVKGVGSERAYELLGHESLQTFGGSGFLQDYPLEQYVRDAKIDTLYEGTTAIQSLDLIFRKIVRDNGKALMAVAAEIQEFITSEGGNGQLKQERQALGKALTEIQTILGVLTGWLGEAQGGDTRALYKVGLASRRFLLAIGDLVVGWLLQKQAEVALKALAGEVSAADKAFYTGKVAAARFFSREVLPRIGADRRIIEGTDLEIMDLPEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAJ8</accession>
    <name>F4FAJ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PII uridylyl-transferase</fullName>
            <ecNumber evidence="10">2.7.7.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_11555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.59" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732095.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11555"/>
    <dbReference type="EnsemblBacteria" id="AEB43425">
        <property type="protein sequence ID" value="AEB43425"/>
        <property type="gene ID" value="VAB18032_11555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11555"/>
    <dbReference type="eggNOG" id="COG2844">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012833_2_0_11"/>
    <dbReference type="OMA" id="WIAKYVY"/>
    <dbReference type="OrthoDB" id="162558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="9">
        <location>
            <begin position="437"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="608"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="711"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="776" mass="81600" checksum="DFFD80BC5431D2A7" modified="2011-06-28" version="1">MTSLISRQASASSPTAAPKVNEVVGVPAGIGATARRARSDAYDAWLARLLPPRPGVALLAVGGLGRRQCAPYGDLDLVLVHSGVAGIDELAAELWYPIWDAGLRLDHSVRTVAEALSVAQDDVKVALGLLDARLVAGDPDLADTLIRSATDHWRRTAVRQLAPLRETTVARWQAHGELAFLLEGDLKEAAGGLRDVGILRAIAIAGITDALRPAVHAAHLRLLDTRDALHHQVGRRVDRLLAQEREGVAALLGLRQAAPGGPDTAHTAGPGGSAGDGDALLRRVAGDARTVSHALHDAFRAADRLRSGRRRGADGRPLRRPVARDVVEHDGELVLARTAIGARPDPNLSLRVAAAAAVTGLPIARATCEWLATYCPPLPTPWPAEARAALTTLLGAGAGLLPAWETCDRYGLIDGWLPEWTRLRSLPQHNPVHRFTLDRHLVQTAFEASRHTRDVDRPDLLLLAAFLHDIGKGLPGDHSTVGAPIAEAMAARIGLPAAEATLIGTLVRLHLLLPEVATRRDLADPVTISGVAEAVGDVTTLDLLHALARADAAATGPGAWSDWKGRLIAELVARVRTTLDTGAVPEPPAPDPALVAGPLPVVHLTGDRVAVAAADRRGLLATVAGCLALHRLEVLAADASTVDGRALVECRVQPRYGLPPEPVALSSDLRRAVGGDVSVTQRLRGRALAARGAGAEPRVVWHRDAATDAVLLELRAADAAGLLYRVTSALDAAGAQVRAARIATLGGDVVDVFYLVGGWPSDDERTRLEAAVLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAN9</accession>
    <name>F4FAN9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amp-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733309.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17760"/>
    <dbReference type="EnsemblBacteria" id="AEB44654">
        <property type="protein sequence ID" value="AEB44654"/>
        <property type="gene ID" value="VAB18032_17760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17760"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936723_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="168"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="31132" checksum="79E8DD6C7BB6F108" modified="2011-06-28" version="1">MTTLSPATVLAGSARRHADTVAVVDGRVRVTYAELWWEARCYGAGLRAAGVRAGDTVALLAPNVVDFPRVYYAALAAGAHAVPIGAPTSPQTVHLLRGARLLVCHTSQLAAGQWVSARAGVPLVTVGPTRGPSGVPRLEDLSDPAPGGAAADPDTDDDPAGRTATDPDDGDVVLSCLPLGGRFGQDVALTGTFAAGATLVLLSRFTGPAALELMLREEVTVFHGTSAMYAALLDAARGRQTLPRLRRCVSRTPLPPALGQPFTTAFATVVTVAEEKSRYGGGRRQRWRCRHRQGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAQ0</accession>
    <name>F4FAQ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microcompartments protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733320.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17815"/>
    <dbReference type="EnsemblBacteria" id="AEB44665">
        <property type="protein sequence ID" value="AEB44665"/>
        <property type="gene ID" value="VAB18032_17815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17815"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064903_5_3_11"/>
    <dbReference type="OrthoDB" id="2004499at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="96" mass="9994" checksum="033A8D8FD1C581E3" modified="2011-06-28" version="1">MRNMAAGFVEAEGYTAIFDAVDAMVKATEVEVTRVVRLGGGIVAVALRGDLATVEEAVDIGEETAKAKSRKVRSIVFASPCDAVSALAVDPRLVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAQ3</accession>
    <name>F4FAQ3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-oxoprolinase (ATP-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733323.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17830"/>
    <dbReference type="EnsemblBacteria" id="AEB44668">
        <property type="protein sequence ID" value="AEB44668"/>
        <property type="gene ID" value="VAB18032_17830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17830"/>
    <dbReference type="eggNOG" id="COG0146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020413_1_0_11"/>
    <dbReference type="OMA" id="GETYNCP"/>
    <dbReference type="OrthoDB" id="1018930at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_B" evidence="1">
        <location>
            <begin position="6"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="679" mass="73437" checksum="83853AF42FCA8BC0" modified="2011-06-28" version="1">MTKTLNPIDLEIVTEGLISIVREMRQTIFRTAHSPVIADAQDFSCALFDPQGQMVAQGRDMPGHVIAMPASVAEIFADFADEMRPGDLYIVNDPYRGGSHLNDVTLITPVFVDGELFLFPCVRMHWADIGGMTPGSVSGQATEILQEGLRIPPIKLIEQGRPNAAAYAILFANVRMADERRGDLESCIAACFTAERRLRELVGRYGAPLLLDSVAANMDRTEQRLRDRIRQLPDGVYRYEDYLDLYTDGRYDPALVRCVLTIDGDEIDADFRGSSTQVAAVVNSSRAMTVAGVFIAVKSALDPGGLVNHGAFRPLRVHTEPGTVVHVAYPAPANAHSEVRKRVISAVMATLSQVAPDLIAADQFGTTFQNLIGGVDQRTGRSYLYYDYPAGGNGGFLESDGPSAMNPVDLGDISTIQSVERLETEIPIVVDASELRLGSCGDGARRGGLGSRRETRLLASNGAYSVQTDRTTVPPYGLHRGGPGAPTVTFVRRADGERVDFDTPGKVAGFAMRSGDVLVMESAGGGGWGDPLEREPAAVADDVTQGYLDADDAQHRYGLRFDADGRVDAAATAAARQELRRRRTWLRVGTTDRQPYTGERGRRRLAYVGPGTGLADGALVEIHGPHPAPLRAWVRHDPDLTDDQLALDDDGLQILGAEPDERTFVRVLADRGTTGEGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAQ7</accession>
    <name>F4FAQ7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_17850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733327.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17850"/>
    <dbReference type="EnsemblBacteria" id="AEB44672">
        <property type="protein sequence ID" value="AEB44672"/>
        <property type="gene ID" value="VAB18032_17850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17850"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_3_3_11"/>
    <dbReference type="OMA" id="NTPNIGW"/>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="367"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB44672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="452" mass="48545" checksum="6B3815AF1826DAC0" modified="2011-06-28" version="1">MQLGSCFLDSLTVTSFFGNAEMRGVFNDRQLMQSWLDVEAALARGQASLGIIPQAAADAISATARLEKLDAAALAADAEDTVHPLVPLVRALTAACPGDAGRYVHLGATTQDVMDTGFVLRARAGLDIVGRQLDELVRLLRRLALRHRSTPMPARTHGQQALPTTFGLRLAAWQSELQRHRARLREMRARLLVTSMGGAAGTMAGYGPQAFALERAVAEELGLGVADTPWHATSDRFAECLMVLGLVASSGEKLAREVYFLGRTEVGEAYEPQRATQVGSSTMPHKRNPIRCEAVIAAASTLRAQVPLALQTMVAQDDRDMGVGMTLWKLLPECFILIGGVLERLVEVFGDLGVNPDRMRANLDITGGLVLSEAVMLRLAGPLGREQAHHLVMRVVRDSLEQGRPFAEVLRGDPEVAAALSGGDIAELLDPLSYVGHAAALVDRALLTSESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBF8</accession>
    <name>F4FBF8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05640"/>
    <dbReference type="EnsemblBacteria" id="AEB42254">
        <property type="protein sequence ID" value="AEB42254"/>
        <property type="gene ID" value="VAB18032_05640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05640"/>
    <dbReference type="HOGENOM" id="CLU_3049164_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="54" mass="5636" checksum="BAA31B3462ED34A6" modified="2011-06-28" version="1">MTSRHGRHAWSGGIVSDMFFDADNALVLAWAGTRRDSATSVGSALPTQGEEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC07</accession>
    <name>F4FC07_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_24535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734657.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24535"/>
    <dbReference type="EnsemblBacteria" id="AEB46005">
        <property type="protein sequence ID" value="AEB46005"/>
        <property type="gene ID" value="VAB18032_24535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24535"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_27_1_11"/>
    <dbReference type="OMA" id="HLGDYMN"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="46"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="244"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="463" mass="48476" checksum="BF24C83C5D21DF6C" modified="2011-06-28" version="1">MAARRPHQITSSPAPTFAELGVPDALNRVLAASGVDRPFPIQAATLPDALAGRDVLGRGRTGSGKTYAFVLAVLTRLAASRTPRRAGRPRALILVPTRELATQIDSVMAPLAQALSLRTMTIFGGVAARPQIAGLRAGVDVLVACPGRLADHVGTGAAHLDAVEITVLDEADHMADLGFLPTVRRLLEQTPRGGQRLLFSATLDAGVDVLVRRFLTDPAVHSVDSGLSPVTAMAHHVLHVEPSDRFEVLVELTAAPGRTVVFTRTKRGAKTLARRLVAAGVTAVELHGNLAQGARTRNLQAFADGQVHTLVATDIAARGIHVDDVALVVHADPPVEHKAYLHRSGRTARAGAAGTVVTLMTDGQVPEVRELTRKAGITATTTRLRPGDALLRELAPGERTLVPRPVMPAADVRHDAPPANGGRGRRGGKPATAAVASTRSAPARGGVAAFSARARPSARRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC96</accession>
    <name>F4FC96_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_00955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735919.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00955"/>
    <dbReference type="EnsemblBacteria" id="AEB47275">
        <property type="protein sequence ID" value="AEB47275"/>
        <property type="gene ID" value="VAB18032_00955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00955"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174611_2_2_11"/>
    <dbReference type="OMA" id="WEIEILT"/>
    <dbReference type="OrthoDB" id="2084255at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="66" mass="6795" checksum="A6E6ED7CE107757B" modified="2011-06-28" version="1">MELTVNGVERDVPDGATVADLVRQVTPQQRGVAVAVNGEVVPRTGWPATALRGGDRVEVLSAAQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCC4</accession>
    <name>F4FCC4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ordered locus">VAB18032_01095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007073023.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="SMR" id="F4FCC4"/>
    <dbReference type="STRING" id="263358.VAB18032_01095"/>
    <dbReference type="EnsemblBacteria" id="AEB47303">
        <property type="protein sequence ID" value="AEB47303"/>
        <property type="gene ID" value="VAB18032_01095"/>
    </dbReference>
    <dbReference type="GeneID" id="5705096"/>
    <dbReference type="GeneID" id="67457621"/>
    <dbReference type="KEGG" id="vma:VAB18032_01095"/>
    <dbReference type="PATRIC" id="fig|391037.6.peg.4343"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_11"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="6895" checksum="6E6F66A29B07382F" modified="2011-06-28" version="1">MAKKALILKAAAKPKFSVRAYTRCQRCGRPKAVYRKFGLCRVCIREMAHRGELPGVSKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCQ6</accession>
    <name>F4FCQ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH/ubiquinone/plastoquinone (Complex i)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_12180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732219.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12180"/>
    <dbReference type="EnsemblBacteria" id="AEB43550">
        <property type="protein sequence ID" value="AEB43550"/>
        <property type="gene ID" value="VAB18032_12180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12180"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_2_11"/>
    <dbReference type="OMA" id="YVAHHIT"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="130"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="500" mass="51788" checksum="5DDBC5DE4F16C155" modified="2011-06-28" version="1">MSALVPLPVLLPLLGAALTLLLANRPLPQRMVSVGCLSATLLVSVLLLMRAYQHGPLVVQIGAWPAPVGIVLVADQLAALMLVVSSAVTLCVLLYSIGQGQGETGESAPLAIFHPTYLVLTAGVTNAFLAGDLFNLYVGFEMLLAASFVLITLNGTRLRIRTGSTYVVVNVLASMIFLVSVGLVYAATGTLNLAHLAARLDALPDGVRLSLQLMLLLAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRTQTLLFPGGQAGTLLLVVAGLTMLVGILGAVAQSDMKRLFSFTLVSHIGYMIFGVGLSTVAGLVGAIFYVVHHITIQTTLFLVAGLVEQRTGSTDLRRLGGLARVAPLLGLLFFVSAMNLAGIPPFSGFLGKLGLLQAGAAVGGALPWTLVAVGTVTSLLTLYVASRAWSMAFWRVPCVTVNSSAPLPMLTVGATAALVVLGVALTVAAGPLFDVTTGAAVDLRERTPYIHAVLPGGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCV1</accession>
    <name>F4FCV1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732264.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12405"/>
    <dbReference type="EnsemblBacteria" id="AEB43595">
        <property type="protein sequence ID" value="AEB43595"/>
        <property type="gene ID" value="VAB18032_12405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12405"/>
    <dbReference type="eggNOG" id="ENOG5030BJM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_1_11"/>
    <dbReference type="OMA" id="WKAFLST"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="6841" checksum="9F1A5D4A3211E3C4" modified="2011-06-28" version="1">METPDRLVWRKSSYSDNNGGACVEVATRRGNVIVRDSKNAAGPVLRFDGQSWSAFLRTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCV4</accession>
    <name>F4FCV4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18420"/>
    <dbReference type="EnsemblBacteria" id="AEB44786">
        <property type="protein sequence ID" value="AEB44786"/>
        <property type="gene ID" value="VAB18032_18420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18420"/>
    <dbReference type="eggNOG" id="ENOG5032TRU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1458417_0_0_11"/>
    <dbReference type="OMA" id="NMAYDSA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046029">
        <property type="entry name" value="DUF5987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19449">
        <property type="entry name" value="DUF5987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="18658" checksum="CA8B937D6811B6D5" modified="2011-06-28" version="1">MVLEAYADTILPGEKRWPGDRAVAGVSSDGGAVAAGALLALRSPEGGLAPALDALADGLDEHAEEYAAETGIELDPEVPAFVSLDFPDRVRLVQRLTDPTHPEREAWISLAMFSVIAFDAAAHSHTVEALDAGHVGLKIIGFRQPDSDGLWRFDTYSYGRQLAQPHPDTTASGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCY8</accession>
    <name>F4FCY8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733475.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18590"/>
    <dbReference type="EnsemblBacteria" id="AEB44820">
        <property type="protein sequence ID" value="AEB44820"/>
        <property type="gene ID" value="VAB18032_18590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18590"/>
    <dbReference type="eggNOG" id="ENOG50340F3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1785839_0_0_11"/>
    <dbReference type="OMA" id="LAWQERT"/>
    <dbReference type="OrthoDB" id="1635062at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032584">
        <property type="entry name" value="DUF4913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16259">
        <property type="entry name" value="DUF4913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="137" mass="15583" checksum="DB45F51FBBF187E2" modified="2011-06-28" version="1">MTQVGPVVEETDEEGKPFFILYLDAAEYEEELRRLSYWVANLLLPVYGGEVSSSSPWCPRWWEHPEAIAYLHGLWLAWQERTGPQANGSDPATWHQSHLWPTMDALRSPNGPFAGCKPGSHRSKERPQVDGDAPHSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD90</accession>
    <name>F4FD90_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_25110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734772.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25110"/>
    <dbReference type="EnsemblBacteria" id="AEB46120">
        <property type="protein sequence ID" value="AEB46120"/>
        <property type="gene ID" value="VAB18032_25110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25110"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_13_0_11"/>
    <dbReference type="OMA" id="HRIRAMI"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="409" mass="41456" checksum="CDB06D30A89E3BD1" modified="2011-06-28" version="1">MDRNRRSLGRPFWTFWSAAALANLGDGIRVAAFPLLAATLTDNPLAVAAVAAAQFLPWLVSGLLAGALADRRGARSLLTVADTGRVVVLGTLAAAIALGWATIALVVAAAFLLGVGETIRDTAAQTAVPRLVPDAQLEKANGRLVAGEIVGNEFVGPPVGALLFVVGAAIPFAVNGATLALAVMLVLSLPLTLAHRRGSDDDAPVADGDGVLAGLRWLVRQPMLRTLVLVTAAVAAADTAWFAIFVLYARDALDLGAFGFGLLLATGAVGGLLGSFTADRLIARFRHRTVLTWSMAVTAGVPVLLAVVADRTVAVVVVVATSAAFAVLNVAALSVRQRLVPGGLLGRVVAAARLVTYSATALGALAGGALAARAGLGAPFVFSGAVAVAATAAWWLASRPATPGALGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDE2</accession>
    <name>F4FDE2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735989.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01345"/>
    <dbReference type="EnsemblBacteria" id="AEB47353">
        <property type="protein sequence ID" value="AEB47353"/>
        <property type="gene ID" value="VAB18032_01345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01345"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_4_0_11"/>
    <dbReference type="OMA" id="PFDVFLE"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="191" mass="21277" checksum="A5D318E16D9DF595" modified="2011-06-28" version="1">MTAALHDDQPPSGEWTTDDLDALPDDGRRRELLDGVLLVSPSPTAAHQTIAMRLGVALEAECPDEYEVTQGVEVRIDRTRSFVPDVLVITAPAAQRRPARYEPHEVVLAVEIVSPSTRSIDRVLKPALYAQAGIPYYWRIETDPAGLVVHTHRIDPVHEVYTETGRWTKFVDTGEPFSVNLSVAQLTPRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDJ0</accession>
    <name>F4FDJ0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoI</name>
        <name evidence="8" type="ordered locus">VAB18032_06145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731026.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06145"/>
    <dbReference type="EnsemblBacteria" id="AEB42353">
        <property type="protein sequence ID" value="AEB42353"/>
        <property type="gene ID" value="VAB18032_06145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06145"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_0_11"/>
    <dbReference type="OMA" id="VDTPHAI"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="23430" checksum="29D025CC1E4C0FAD" modified="2011-06-28" version="1">MGAITGTFKGFGVTFSHMFKKVVTTDYPFTPPTPAPRYHGRHILNRHPDGLEKCIGCELCAWACPADAIYVEGGDNTDEQRFSPGERYASVYQINYARCIFCGLCIEACPTRSLTMSNEYELARDNRQDLIFTKEQLLAPLLEGMEQPPHPMRLGESEKDYYVGSLTNPGTSAGAERSPMGPGRYQVDEHPGVTFPGAEQAAQRAAAEKGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDQ8</accession>
    <name>F4FDQ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nudix hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_06485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731094.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42421">
        <property type="protein sequence ID" value="AEB42421"/>
        <property type="gene ID" value="VAB18032_06485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06485"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_7_3_11"/>
    <dbReference type="OMA" id="HRWAIPA"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="18096" checksum="4AAC829105CC0377" modified="2011-06-28" version="1">MSISWADSYVGQLRALAGDRTLMFVGARAVVRDSSARVLLIRRSDNGQWALPAGAMELGESIADCAVREVREETGLRALRVSAFALYTGADRTHTNMYGHTYQVFTTAFRVEEWDGQLARITDETTDAGFFHRKAMPHPLSASVAETLADLDVFEQTNRLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDS6</accession>
    <name>F4FDS6_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Activator of hsp90 atpase 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12465"/>
    <dbReference type="EnsemblBacteria" id="AEB43607">
        <property type="protein sequence ID" value="AEB43607"/>
        <property type="gene ID" value="VAB18032_12465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12465"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_6_3_11"/>
    <dbReference type="OMA" id="FYGMESW"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="18267" checksum="BE668DA0181D8FC9" modified="2011-06-28" version="1">MIDDYLVVDTPGDREIVLSRMFDAPARLVFAAFTRPELLVRWYGARGWRLVECQVDLRVGGPWRFVSQGPAGQLMGQSGHYRQIEPPHRLVYTELFDDQSYPGETVVDQEFTELAGRTTVTTTLRFATPGGRDTALRYPMARGVTESYIRLAGLLATTPGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDV4</accession>
    <name>F4FDV4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732303.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12605"/>
    <dbReference type="EnsemblBacteria" id="AEB43635">
        <property type="protein sequence ID" value="AEB43635"/>
        <property type="gene ID" value="VAB18032_12605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12605"/>
    <dbReference type="eggNOG" id="ENOG5030NZ9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069776_1_2_11"/>
    <dbReference type="OMA" id="DIPDNKP"/>
    <dbReference type="OrthoDB" id="1206711at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="22967" checksum="E207DDD9E908329E" modified="2011-06-28" version="1">MIFSRKRATGRHASDERAVEAPDTVEAAPAEPARGPYDVSEAPAGVQRLDLGSLQIPAVPDVEVRVQADPQGVIQQVVLVHGQSALQLGVFAAPRSEGIWDEVREEIRQSLFNDGAAAQEVTGEYGTELRARVRTEDGLTDLRFVGIDGPRWMVRAVYQGEAATNPAAAGALARCMEGLVVDRGMEAKPVREPLPLRLPREAGEQAAAADAAPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDY2</accession>
    <name>F4FDY2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding domain 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_12745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732331.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="SMR" id="F4FDY2"/>
    <dbReference type="STRING" id="263358.VAB18032_12745"/>
    <dbReference type="EnsemblBacteria" id="AEB43663">
        <property type="protein sequence ID" value="AEB43663"/>
        <property type="gene ID" value="VAB18032_12745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12745"/>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063855_0_0_11"/>
    <dbReference type="OMA" id="WNWNGLF"/>
    <dbReference type="OrthoDB" id="1005693at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307832" evidence="2">
        <location>
            <begin position="32"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="259"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="362" mass="38166" checksum="DDFB9A9AA502AC16" modified="2011-06-28" version="1">MLKPARLAGLLATAAAATLLVSTALVNSASAHGSVVNPGARAYSCWERWGGDHMNPRMATEDPMCWQAWQANPQAMWNWNGQFREGVGGNHQAAIPDGQLCSGGRAEGGRYNALDTIGAWRTTQVSNSFRLKFFDQASHGADYIRVYATKQGFDALTKPLAWSDLELVGQIGNTPASQWQREVDGVSIEIPVNAPGRSGRHIIYTIWQASHFDQSYYHCSDVQFGGSTNPPPTTPPPTTPPPTTPPPTTPPPSTPPPSNPPPAGACSATYQVTNSWSGGFQGEVKVTAGSAAIRSWRVTWTYANGQQVSQAWNATLSSSGSTVTATNVSYNGSLGSGASTTFGFLASGSSASAPTLTCTATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEE6</accession>
    <name>F4FEE6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyhydroxybutyrate depolymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734864.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25570"/>
    <dbReference type="EnsemblBacteria" id="AEB46212">
        <property type="protein sequence ID" value="AEB46212"/>
        <property type="gene ID" value="VAB18032_25570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25570"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_4_0_11"/>
    <dbReference type="OMA" id="ATDTIWQ"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="26805" checksum="6F861BEDE9BAB7AA" modified="2011-06-28" version="1">MTLDHGGLSRSYRLHAPPGYAPARPVPLVIALHPYPGTGLEMSQLFGWDTVAEREGLLVAYPDGVHGGFNAMVCCGNADDVGFLAALTGHLVDTWHVDPDRVYLTGISNGGDLSFRAAVEAGGTFAAIGVVSGGFIGERTNADEYAPQQPVSVVTFIGERDRYALPFRTGIDRWRQRLGCTSVTPPPVAPAEDVTLSRARCADGSDLDVYLIGSMGHSWPGASGDRLSAPEVEVNATELIWTFFAAHPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEP9</accession>
    <name>F4FEP9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xanthine/uracil/vitamin C permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_06595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731116.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06595"/>
    <dbReference type="EnsemblBacteria" id="AEB42443">
        <property type="protein sequence ID" value="AEB42443"/>
        <property type="gene ID" value="VAB18032_06595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06595"/>
    <dbReference type="eggNOG" id="COG2252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_0_0_11"/>
    <dbReference type="OMA" id="YVDIIDC"/>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="491" mass="51111" checksum="6B37C3521AB988D6" modified="2011-06-28" version="1">MSVAPLDNTPPDPGRPVNRFDRYFEVTARGSTMTRELRGGLATFFTMAYIVVLNPLILGGAVDGDGKALAIPAIAAATALVAGLMTILMGVVGRFPLAVAAGLGVNALVAYEIAPQMTWADAMGLVVIEGVIIAVLVLTGLRTAVFRSVPTQMKTAIGVGIGLFLTIIGLVDAGFVRRIPDAANSTVPLGLGIGGKLASWPTLVFVLGLLLTLVLVVRRVKGAILIGIFASTALAMVVEALGNVGPSFVNGVPNPKGWSLNVPTLPSNPVDLPDLSLIGQFNVLGSWERAGWLVVLMFIFTLLVTDFFDTMGTMVAVGQEGSMLDEQGTPPRAKEILLVDSIGAAAGGAASVSSNTAYIESAAGVAEGARTGVANLVTGALFLLAMFLAPLVVVVPFEAASVALVVVGFLMMTAVRTIDWSDYEIAIPAFLTIVLMPFTYSISNGIGAGLITYVVIKLAKGKAREVHPLLYAVAALFVVYFLRGPIEALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FET1</accession>
    <name>F4FET1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06755"/>
    <dbReference type="EnsemblBacteria" id="AEB42475">
        <property type="protein sequence ID" value="AEB42475"/>
        <property type="gene ID" value="VAB18032_06755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06755"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130332_2_3_11"/>
    <dbReference type="OMA" id="YCIDVAN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="100" mass="10999" checksum="BB95ECD5A2961140" modified="2011-06-28" version="1">MLMTTPTPIRGYTASKDQLLARLRRVEGQVRGVEKMVDEDRYCIDVLTQISAIQAALDKVALGLLDGHARHCMHEGAAEGRADEMATEMMAAVGRLMKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEU3</accession>
    <name>F4FEU3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_06815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731160.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06815"/>
    <dbReference type="EnsemblBacteria" id="AEB42487">
        <property type="protein sequence ID" value="AEB42487"/>
        <property type="gene ID" value="VAB18032_06815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06815"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_2_1_11"/>
    <dbReference type="OMA" id="RRFLTYH"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="831"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="10">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB42487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="896" mass="95351" checksum="AB44CE491B064992" modified="2011-06-28" version="1">MRGELAVDPQSPLPDLLHRLDASEHGLTTDQARQRLAEYGRNELRRTRRRSWWRELGRQLIHPLALLLWVAAILAWVAGTAVLGAAILAVIAVNAVFASVQERQAERAVEALTRYLPQQARALRDGNWQEVPAGELVPGDVIAIGEGDRISADARLLDGGVEVDLSALTGESQPAYRSADATGPAESLTEAGNLVFSGTSCLSDEARGMIYATGMRTELGRIAALSQRVGREESPLERQVRRVAWLIAAVAIGAGVVFFPIGVLAAGMPISDAFTFAIGLLVANVPEGLLPTITLALAVGVRGLARLGAVVKRLSAVETLGSTTVICTDKTGTITENRMRVTAVRAADELLDPLPNPVPSPGPALSALAATAAACNNAELRPDADVGDPTETALLHFAAKIRQPAGSRRQSQFHFDPRLRLMSTVDAVGADLWLHTKGAPEEVLRRCTRIIGADGDDRPLTEQARAELAEAVTGQARQGRRVLALARRRLTGPPGDRDTTERELTFLGFVAMVDPPRAAVPDAVAKCHTAGIRIIMVTGDHGLTATAVARQVGITRGDPTVLTGADLDRMTPQALRDLLAEQREVIFARVSPEAKLHIAEALRADGQIVAMTGDGVNDAPALRRADIGVAMGRSGTDVTREAATMVLTDDNFATIVAAVGAGRRVYANVRKFILYILAHTTPEVVPFLIFALSAGAVPLPLTVLQILAIDLGTETLPALALGREPAEPGLMNRPPRRRTERVIDRQMLLRAWAFLGLVSAVLVMAGFFAVLLAGGWTPGAPTGPGTALHETYLQATTMTFLGIVACQIGTAFAARTERAPLRAVGVFSNRLLLWGIAFELAVAAVIVALPPLPEVFGTRPPPAPALALLLVFPVVVWGADELRRRLIRGRTHPAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF84</accession>
    <name>F4FF84_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_19435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733644.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19435"/>
    <dbReference type="EnsemblBacteria" id="AEB44989">
        <property type="protein sequence ID" value="AEB44989"/>
        <property type="gene ID" value="VAB18032_19435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19435"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OMA" id="WTWNQFL"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="275" mass="29972" checksum="BAD842D93FCE0CEB" modified="2011-06-28" version="1">MNLTSRSERVSGRIFLIALVVVTLLPFLSMLSAALQPRGTVPTGLAWPSDPQWSNFADAFTAANMGALLKSSMLIVAGVVPIGVLIATMAGFGLGHLRVPGGHIAFGLLLLGLTLPFEAVVTPLYYQMRDLGLLNTRWAIILPLIGLYMPFAVFWMRAHFTNVPAELSEAARVDGSNTWQLFWRIHVPLARPAIASLTILLFLWTWNQFLLAIVMVDDATKRTMAGALGAFQGQWGTDLVLLCAGSLLILTPTLIVFLIFQRQFIKALLQGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF86</accession>
    <name>F4FF86_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733646.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19445"/>
    <dbReference type="EnsemblBacteria" id="AEB44991">
        <property type="protein sequence ID" value="AEB44991"/>
        <property type="gene ID" value="VAB18032_19445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19445"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_1_1_11"/>
    <dbReference type="OMA" id="GPRVFFQ"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="16863" checksum="91BF48D8565D9ACC" modified="2011-06-28" version="1">MSRHIQVTFDAHDPTALSSFWRDVLGYVHPGPPGVDLPDGADPLAAWDDFLARLGVPPEQRNTRSAIEDPDGHGPRLFFQQVPEDKVTKNRVHLDVRVAPGLQGDERMAALEAECDRLVALGASRLRRVEPAPPFESGFIVMADPEGNEFCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFB6</accession>
    <name>F4FFB6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_19595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733676.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19595"/>
    <dbReference type="EnsemblBacteria" id="AEB45021">
        <property type="protein sequence ID" value="AEB45021"/>
        <property type="gene ID" value="VAB18032_19595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19595"/>
    <dbReference type="eggNOG" id="COG5305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_751873_0_0_11"/>
    <dbReference type="OMA" id="ICTAWAL"/>
    <dbReference type="OrthoDB" id="1664452at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="94"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB45021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="354" mass="37442" checksum="351F315197E3F838" modified="2011-06-28" version="1">MKDADTIVLPRLGLPEAAEDPWGEGRGEAPGEPVNGSRRMRLAAWLVPALLMGALGAVRADTPGPRMAELATRAGATSSWRDTWSMLRSGDSVLYHLLVRAWAEYFGTSELALRGLSVLAMVTAAALVGALAARMFAPGTGVLAGVIFALLPTSARYAQEAQPYALTLLAAVLATWLLQAAVGRPRLWRFVLYAAVAGLMGLCQVTALLLLVGHGWTVLAFRREVALRWLAAAVVSALPAVGLLWHATRQGVRLAQTSSPSLTELAATPGELFGVTALGAALLVLVLFSLPLRHPAAVFTAWAAVPPLALLLAAQATPLWRPEFVLFTLPAWATLGAAALARCASAGRRVCWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFF0</accession>
    <name>F4FFF0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734904.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25770"/>
    <dbReference type="EnsemblBacteria" id="AEB46252">
        <property type="protein sequence ID" value="AEB46252"/>
        <property type="gene ID" value="VAB18032_25770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25770"/>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099864_1_0_11"/>
    <dbReference type="OMA" id="ATYRMNI"/>
    <dbReference type="OrthoDB" id="1441395at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307872" description="Peptidase_C39_2 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="48"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="22776" checksum="51D07190F1833A73" modified="2011-06-28" version="1">MRTTMLRKTALTIAAAAATAGGIAGPAIAAQTTPGVAAARDHKTERQLDVRYEAQDTFYYCGPAATRNALSVQGKNIDQHDMAKRMGTTENGTDSINDITPVLNKETGKDVYRSVEIPGTKADDKQTDKLREDIKRTVDDGRAVVANIAGTTTDTTGTTHSFEGGHYISVTGYRDAGKQVKIADSANPATAEYWLTTDNLADWIATRGYTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFI5</accession>
    <name>F4FFI5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein ArsR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734938.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25945"/>
    <dbReference type="EnsemblBacteria" id="AEB46287">
        <property type="protein sequence ID" value="AEB46287"/>
        <property type="gene ID" value="VAB18032_25945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25945"/>
    <dbReference type="eggNOG" id="COG2345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078469_0_0_11"/>
    <dbReference type="OMA" id="LCQGHCP"/>
    <dbReference type="OrthoDB" id="1288973at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="263" mass="27128" checksum="DD3501A280C51642" modified="2011-06-28" version="1">MKKAAGFPEHPSAAGSVADRSTPPASTRPGADAAPSADLSTRSRVTQLLLERRAATAAQLGGALGLSPAAIRRHLDAMLADGDVIAREQTVRGHRGRGRPAKVFLLTDAARSRCGTHHYDNMATAALRWIARTGGPRAVEEFAAEQVAALEARCQAALADAGDEPMARAEALAAALTAEGYAASASTIASGGQLCQHHCPVAHVAAEFPALCEAETTVISRLVGTHVQRLATIAHGDGVCTTHIPGSPPAQSGMTVTTVRTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFQ7</accession>
    <name>F4FFQ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02250"/>
    <dbReference type="EnsemblBacteria" id="AEB47534">
        <property type="protein sequence ID" value="AEB47534"/>
        <property type="gene ID" value="VAB18032_02250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02250"/>
    <dbReference type="HOGENOM" id="CLU_3241125_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="43" mass="4279" checksum="1D2699DDDEDAA4CB" modified="2011-06-28" version="1">MALLVLLGVPALVVALCCGVIQVVTKSSVDDPLSVRGGISTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFS8</accession>
    <name>F4FFS8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosinetriphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736188.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02355"/>
    <dbReference type="EnsemblBacteria" id="AEB47555">
        <property type="protein sequence ID" value="AEB47555"/>
        <property type="gene ID" value="VAB18032_02355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02355"/>
    <dbReference type="eggNOG" id="COG1222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_11"/>
    <dbReference type="OMA" id="RAPDLCD"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="296"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="549"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="777" mass="80387" checksum="3026FB74820D23F6" modified="2011-06-28" version="1">MGEPELTLTASLRAAALDARRGIVRLHPEVLTALGLRPGDPVRLTGRRVTAGIVAPAEPTASSALLHADDLMLGNLGVRDGGQVRVSAAPTVAAARVLLAGPAEVVAVVSPEMLRLALLGKVVTTGDDVSLLPQDVLPDAATRSLVEVARRSLSTRVGYAWTSTLLRVVAAEPEVGALVTMDTTVGWEHGARTHGVAGSLAGRAASLAGAGGMGTPSPTDTSRFDTAARFGGFDAGQAGDVDADAASAGWSGGESTEHVASVDELPGLRSQAEELTELLDLGFHHREVLGRLSTTVALGVLVSGPAGSGKSALVRAVAAQVGARVHALWAPEIAALSNSSAAARLRATTAEVIADGPAVLLVTDVEALAPADTPGPVATVFRQCLAQIVQAGAAVVCTTSRPEALDPAMRAPDLLSLRIDVPLPDAALRREQLTVLTRPVPLADDVRLDEVAGRTPGFVAADLAALVREAGIRAALRQKSDENPTVRMADFTAALEVVRPTSMAASTLELARVTLDDVGDLVEVKQQLTESVLWPLTYPDTFARLGVQPPRGVLLYGPPGCGKTYLVTALAGSGRANVLSVKGAELLSKWVGESERAVRELFRRAQEAAPTLVFLDELDALAPVRGQATDGGTTDRVVAALLTELDGVEALRNVVVVGATNRPDLIDPALLRPGRLERLVYVPPPDAEARAAILRAAARNVPLAEDVDLGALGADLDGFSAADCAALVREAALAAMRESLTAATVTAAHVETARARVRPSLDPAQVAWLAAYAEQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFV4</accession>
    <name>F4FFV4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_07050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07050"/>
    <dbReference type="EnsemblBacteria" id="AEB42534">
        <property type="protein sequence ID" value="AEB42534"/>
        <property type="gene ID" value="VAB18032_07050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07050"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_5_1_11"/>
    <dbReference type="OMA" id="QHETEAC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="206"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="357" mass="38395" checksum="8665B1403558DA56" modified="2011-06-28" version="1">MTMDFALTDEQRAIRQAARDHLERHYPPLRVCALAEGPGGSEAGAWPELIRQGWLDDDLGMVELTLLAEESGRCLHPTPWWTTVALAAPYARAAREQLTVPATFADGGGTVRAARSPQGWTLTGQVAAVPQAGAVRCLVVRADTDQGPAVFACDTGSAGLVVAELSTLDTLRRMARVRCDGTPARLLVGPDRAAEAARTARLRGGVLLAAEAVGVAAGALDMAVAHARQREQFGRPIGSFQAVAHQLTEAYVDTESARSLAYRAAWLVQHETEACAQAVDEAVLVARSAAVRTCETAIQITGGMGVTWEYPLHRWLRRALWLEAYPGFGDDPHDRVAERLLRRADPDEITPTAPDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFV9</accession>
    <name>F4FFV9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA_dh_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07075"/>
    <dbReference type="EnsemblBacteria" id="AEB42539">
        <property type="protein sequence ID" value="AEB42539"/>
        <property type="gene ID" value="VAB18032_07075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07075"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045511_0_0_11"/>
    <dbReference type="OMA" id="LRAWAIN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="341" mass="36065" checksum="BBBD4B9EB0879FC5" modified="2011-06-28" version="1">MTVSIDESTSLRQAREIADEVFFPAALAVDAADRVPISHLDLLAEHGFYGLAAPPEFNRLDLPSFPAVCRVIETLASGCLTTTFLWAQHHNAVMAAANTGNAELRAAWLEPLATGQRRAGLAIGAAVRPGPAALSATPVDGGFLFSGAAPWVSGWGLVDTIYVAARVSDDTLVFALVDAATSDTLTVEPLRMSAVNASSTVTVTFDNHFVPADRVANQMPLEAWRQRDPATLRFNGSLALGVADRAIELADEPRLRSQLDAVRDRLDSADPETMPAARAAASELALRASANLAVAAGSRAVLLDQHAQRLVREATFLLVFGSRPGIRDALHTTLTTSPGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFY8</accession>
    <name>F4FFY8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07220"/>
    <dbReference type="EnsemblBacteria" id="AEB42568">
        <property type="protein sequence ID" value="AEB42568"/>
        <property type="gene ID" value="VAB18032_07220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07220"/>
    <dbReference type="eggNOG" id="ENOG5030N64">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109716_0_0_11"/>
    <dbReference type="OMA" id="TGIWHET"/>
    <dbReference type="OrthoDB" id="1681539at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="DUF4188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="187" mass="20626" checksum="1E7B5060EB23F4E1" modified="2011-06-28" version="1">MTAEIEGDFAVFMTGMRINNFFKVNRWLPTFWSMGGVLKAMFADQEATGALHAHAYWGNRGAVMIAYFRSIEHLERFANNRELAHSKALQDYFRRMKDNNVVGIWHESYVVRNGEYEAVYNHMPEATGLAAAGECVPVNRRGNSASARRATGARTAAEAAAGSGRDVEPVAPVVDEIFPAVAADRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFZ1</accession>
    <name>F4FFZ1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731244.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07235"/>
    <dbReference type="EnsemblBacteria" id="AEB42571">
        <property type="protein sequence ID" value="AEB42571"/>
        <property type="gene ID" value="VAB18032_07235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07235"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054755_0_0_11"/>
    <dbReference type="OMA" id="LGCVDLH"/>
    <dbReference type="OrthoDB" id="949624at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="428" mass="46932" checksum="5E817BB53BEA9C6D" modified="2011-06-28" version="1">MAVNTAESVVTVRPFVSTVDGSDVIIGDTDRKVYLAIPAEGLDILNALAEGRTIAETARIYERKHGEPVDVEDFVAVLADEGFVTRGGEPEAATEPAHQHAHRTVKRWSFDWIPPATARRLTGPAVILPGLAVILTAVALVITDPGLIPGPRVLLFEGGNFAILTVVSVTLAMIGLSLHELAHALAARSVGVSATLGISNLMYVLVAQTDISGIWMASKRARYKAFLAGFFVDAFFGSLLVAFLFATRRNLIDVPNWASLLASAALLTFLVRIGFQFFFYLRTDVYYVIATALNCRNLMSDTERFLSNGIKRLTFRRHKVISQAGIPRREMRKIRAYAAVWVFGRVFGLVALIFTILPMLWVYLEQFVLLALGEPTRFSSADFATVAVLAALLNGGGLAMWGRNLWRGWRRRRVEDARTLARQAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG10</accession>
    <name>F4FG10_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732422.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43754">
        <property type="protein sequence ID" value="AEB43754"/>
        <property type="gene ID" value="VAB18032_13200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13200"/>
    <dbReference type="eggNOG" id="ENOG5031MXI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1832871_0_0_11"/>
    <dbReference type="OMA" id="PERHPGK"/>
    <dbReference type="OrthoDB" id="2035449at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="133" mass="13814" checksum="FF42685C466D6B96" modified="2011-06-28" version="1">MREDDLRQDAARRAEERLTAGVYGEGALDEVTVPPTDVNSAIQRDDPDDPAKVPIDPNVLRDGGPTRGQGAITTTGGTAGPASVRRVARQPERHRGKVAPTTTGDATTGGLSTPRGGSTSDQSTPATHVGNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG32</accession>
    <name>F4FG32_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_13320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732443.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13320"/>
    <dbReference type="EnsemblBacteria" id="AEB43776">
        <property type="protein sequence ID" value="AEB43776"/>
        <property type="gene ID" value="VAB18032_13320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13320"/>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_4_0_11"/>
    <dbReference type="OMA" id="VEYREQG"/>
    <dbReference type="OrthoDB" id="1508841at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="20814" checksum="5569F62C46244D98" modified="2011-06-28" version="1">MNDDHDAAGAIRFIFEAGVLKRAARTGWWFAGIKHPESIAEHSFRTALIGMMLAAMEGADPARVSMLCVLHDTQETRITDIPHIAKRYLTAAPNTTVTADQVAACPPAVADLINAAVAEYEAGETPEAIVARDADKLECLIQAVEYRHQGIDNVQRWIDSSRAALKTTSAHRLADAALTGQPLAWLTPPPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG38</accession>
    <name>F4FG38_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13350"/>
    <dbReference type="EnsemblBacteria" id="AEB43782">
        <property type="protein sequence ID" value="AEB43782"/>
        <property type="gene ID" value="VAB18032_13350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13350"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124815_0_0_11"/>
    <dbReference type="OMA" id="YLIREWE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="170" mass="18474" checksum="A5B07DD259F80B06" modified="2011-06-28" version="1">MLDPAAVFDGTGPLEDPLTDEVLRSVQAQLGRRLPTAYVDLARRHNGGSFARTAHPAPSRTSWAEDHVGVDMLAAIGRTARFSLCGEFGSAFWVAEWGYPDIGVYIADCPSAGHDMIALDYRSVGEPAVVHVDQEWNYRITVLAPDFETFVAGLVDESELEAEARADPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGC4</accession>
    <name>F4FGC4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19800"/>
    <dbReference type="EnsemblBacteria" id="AEB45062">
        <property type="protein sequence ID" value="AEB45062"/>
        <property type="gene ID" value="VAB18032_19800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19800"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_21_1_11"/>
    <dbReference type="OMA" id="WIDQLYV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="157" mass="17280" checksum="275195C53C710C01" modified="2011-06-28" version="1">MSATLADIVIRPARDSDADAVAEVFLASRAAAMPYLPRLYDDEQTRAWITQVMLPTSTTWVAESTTTGEILGFAALDGSLLAHLYLRPDARRQGIGTALLTHAQQASPTGLSLRVFARNTAARAFYEHHGFRPIDSNDGSRNEENEPDITYHWPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGC7</accession>
    <name>F4FGC7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MerR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733720.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19815"/>
    <dbReference type="EnsemblBacteria" id="AEB45065">
        <property type="protein sequence ID" value="AEB45065"/>
        <property type="gene ID" value="VAB18032_19815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19815"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_0_11"/>
    <dbReference type="OMA" id="TQMPIAK"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="14191" checksum="5FDDC6CEEE2DCFF5" modified="2011-06-28" version="1">MRTYTPAEAARRSGFSIDTLRYYEREGILAPVARTPGGRRVYRDSDLATLDFLRCLRDAGMPIERLRRYGELCRDPDTVAERVELLREHAAAVQQQMDQLRSWQARVEEKLAWYEKQLEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGM4</accession>
    <name>F4FGM4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellulose-binding family II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_26305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735010.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26305"/>
    <dbReference type="EnsemblBacteria" id="AEB46359">
        <property type="protein sequence ID" value="AEB46359"/>
        <property type="gene ID" value="VAB18032_26305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26305"/>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002616_2_0_11"/>
    <dbReference type="OMA" id="TRRWTFD"/>
    <dbReference type="OrthoDB" id="149095at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10318">
        <property type="entry name" value="RGL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041624">
        <property type="entry name" value="RGI_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034641">
        <property type="entry name" value="RGL11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43118">
        <property type="entry name" value="PTHR43118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18370">
        <property type="entry name" value="RGI_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307718" evidence="2">
        <location>
            <begin position="32"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="759" mass="79924" checksum="47361BE24FB708D5" modified="2011-06-28" version="1">MPRTVRRVIVLATATATTLAAGVLTTLTASAAATGCRVDYRITNQWGGGFGADVTVTNLGDPLNGWTLTWAWPAGQQVTQAWNATVSQSGAQVSARNVDYNATIGTNASTGFGFNGSWTGTNPVPTSFALNGTTCTGATTPTTPPPPTTPPPTTPPPTTPPPTTPPPTTPPPTTPPPGSMQAENLDRGLVSVRSGSANLVSWRLLGTETTGVAFNLYRGGTRVNASPITGATNYLDSGAAAGAAYTVRAVVGGVEQADSAPAVQFPAGYLDVPLQVPPGGTTPSGEAYSYSANDASVGDLDGDGRYEFVLKWEPSNAKDNSQSGYTGNVYVDAYTLTGARLWRIDLGRNIRAGAHYTQFQVYDYDGDGRAEVAMKTADGTRSGTGQVIGNSSADHRNSSGYVLAGPEYLTMFDGRTGAALSTVNYDPPRGTVSSWGDSYGNRVDRFLAATAYLDGQRPSLIMARGYYTRAVIAAWDFRNGSLTKRWTFDSNASGNGAAAGQGNHNLSVADVDADGRQEIVYGAATIDDNGRLLHSTATGHGDAMHVGDLDPSRAGLEVFKVNEDGSKPSSYLADARTGQLIWSTPASGDNGRGVSGDIWAGSPGAESWSSAVSGLSNTRGQNVGRKPSSTNFLIWWDGDPVRELLDATRIDKYGPNGDTRLLTGADVASNNGTKATPALSADILGDWREEVIWRTSDSRALRIYSTPTPTNTRIHTLMHDLQYRVAVAWQNTAYNQPPHPSFFLGDGMAVPPAPRIYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH55</accession>
    <name>F4FH55_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_13605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732500.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13605"/>
    <dbReference type="EnsemblBacteria" id="AEB43833">
        <property type="protein sequence ID" value="AEB43833"/>
        <property type="gene ID" value="VAB18032_13605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13605"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028367_4_1_11"/>
    <dbReference type="OMA" id="VICTHPF"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="6">
        <location>
            <begin position="35"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="269"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="375" mass="40244" checksum="EAB17555AA69EE02" modified="2011-06-28" version="1">MVDDWTEVTLGRTGGASNAPDGRIVVVSADIGAGHDAAAAELERRLTDQGRQVDRLNFLSLLPGPLDVTVRESYRGMLRWLPWCYDALFSATGRSPASVQLLRAALRPVFRRMLARLPPDTRAVVTTFPFANQILGPMRVAGLVNAPLVTYVTDFAVHPTWIAPGVDLYCVVHELSRQQAIAGGSAPVRVVRPLVNARFAASAQLSTQAARRQFGLPEQGRLALIVAGSWGMGDVARTATEVLATGCVEPVVVCGRNQRLYRRLRRFPGHVLGWVDDMPTLMRAADVVVENAGGLTCQEALASGRPTITYRPIAGHGRANADLLSRSALTSYIDSAQRLRPALTELLAAAEGGDPGADARIDMAGVVADVLTPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHB4</accession>
    <name>F4FHB4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="12" type="ordered locus">VAB18032_13900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732559.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13900"/>
    <dbReference type="EnsemblBacteria" id="AEB43892">
        <property type="protein sequence ID" value="AEB43892"/>
        <property type="gene ID" value="VAB18032_13900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13900"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_11"/>
    <dbReference type="OMA" id="FGMKWMM"/>
    <dbReference type="OrthoDB" id="227746at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="229"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="700" mass="78471" checksum="90DF380C1EC461F6" modified="2011-06-28" version="1">MDQLISGETHDPHAVLGAHPANGRTVIRTLRRGATEPCLLVGEQRYPMTRVHEVGVFEATVPGEVLDYRIEWNGQPHDDPYRHPPTLGELDLHLISEGRHERLWEALGARVLDGGVAFTVWAPNARGVRVVGDFTGWAPDDGWPMRSLGSTGVWEIFVPGVQVGARYKYRILGADGHWRDKADPLAGYAEVPPATASVVHRSTYEWGDADWLARRAKQQPHQEPMSVYEVHLGSWRPGLGYRELAEQLAAYVTELGFTHVEFLPVMEHPFGGSWGYQVTGYYAPTSRFGDPDDFRYLVDRLHAAGIGVILDWVPAHFPKDEWALARFDGTPLYEHPDPRRGEHPDWGTYVFDFGRREVRNFLVANALYWLEEFHVDGLRVDAVASMLYLDYSRADGQWVPNQYGGRENLEAIAFMQETNATVYKHHPGVVMIAEESTAWPGVTRPTSDGGLGFGFKWNMGWMHDTLLYTSKDPIYRQHHHHQLTFSLAYAWSENYVLPISHDEVVHGKGSLLGKMPGDQWQRLANVRVLLAYMWAHPGKQLLFMGCELADDREWSEERGLDWYLLHDPARAGVQRLVGDLNRVYRDTPALWAQDTSPAGFRWLAGDDVANNTISFVRIAPDGATLVCVANFSALPLEDYRIGLPAAGAWAELLNTDAHHYGGSGVGNLGTVHAEPVPWHGQPASVALRVPPLGALWLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHD8</accession>
    <name>F4FHD8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type transporter, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733765.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20040"/>
    <dbReference type="EnsemblBacteria" id="AEB45110">
        <property type="protein sequence ID" value="AEB45110"/>
        <property type="gene ID" value="VAB18032_20040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20040"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="ILASHDM"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="307" mass="33489" checksum="F0CA36F1865D5B75" modified="2011-06-28" version="1">MIEVEDLTVAYGSVRAVRGVSFQVAPGEVVALLGRNGAGKTSTMQVLAGHRAATSGRVRVAGGDPYRDRATVRRHVGIMLQEAGFLGELTVAETVQAWRRFGRDPLPRDEVLDLVDLRAQARIRVGRLSGGQRRRLDLALAILHRPRVLFLDEPTTGLDPEARQNTWQVIEGLAQADTTVLLTTHYLQEAERLAGRVLMMEAGRLTVSGDLPTVLSAGTGTVSFAADRLPEDLPTDWPAEYAAGRVVIRTRRLDETAAEVFAWAATRGRVLPQVAVRPASLEDVYLGLTEDRQRGPVDAVPEKVGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHG3</accession>
    <name>F4FHG3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_20175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733790.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20175"/>
    <dbReference type="EnsemblBacteria" id="AEB45135">
        <property type="protein sequence ID" value="AEB45135"/>
        <property type="gene ID" value="VAB18032_20175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20175"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_4_0_11"/>
    <dbReference type="OMA" id="WAWAIAP"/>
    <dbReference type="OrthoDB" id="1808868at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="32301" checksum="F8137BD3E1C27BA4" modified="2011-06-28" version="1">MADEAGDVGSTAAPTGRSFWGWLRLALGLAVLVGLLCWLGTGPFLAGLRLIDAPALAAALALGALTTVCVAWRWSLVAGGLGVGMPLREAVAHCYRAVFLNATLPGGILGDVHRAVRHGRDVGDVGRGIRAVVWERVAGQVVLVAVAVVLLFAFPSPVRPYLPVATAVVVTALVAVVLAARLLPHSGASRFTRAMVTAVADVRAGLLGKRTWAGVLVASALAVAGHLATFLVAARTAGSTAPLTLLLPLTLLALLAMGVPANVAGFGPREGVAAWAFAAAGLTAAEGVATATVYGALVLVASLPGAAVLLARRVRVPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHP9</accession>
    <name>F4FHP9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735069.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26726"/>
    <dbReference type="EnsemblBacteria" id="AEB46418">
        <property type="protein sequence ID" value="AEB46418"/>
        <property type="gene ID" value="VAB18032_26726"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26726"/>
    <dbReference type="eggNOG" id="ENOG5033AGQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084738_0_0_11"/>
    <dbReference type="OMA" id="GRADYTH"/>
    <dbReference type="OrthoDB" id="1924423at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021213">
        <property type="entry name" value="DUF2567"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10821">
        <property type="entry name" value="DUF2567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="29584" checksum="E664E06F271D0AB4" modified="2011-06-28" version="1">MSPEIPAVEPPAAAWPTDPQARVDPPRRNLAVGGAVVLCLTLLGVPLGLLWAAISPATPVIKTADGAVYGQPQPEQPVAADGWFSLLGLAFGVLAGLAVWFVLRRRRGPVGLFAVVVGALAAAVVAWQVGRRVGLSTYERLLDTAPAGTAFTKPADLRAGGIELFLGVLPVPHGNLLLPAFGAAVTYTLLAGWSRWPSLRPEPEPDVALLYPAAGYPPGVPGPAPWPAVPGAGGGYPPAGPGVGPAGPFPGAVGPNGFGPESAAPGGVSSGQAGAWPAPPAAPEPPAPGAAEPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHQ8</accession>
    <name>F4FHQ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735078.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26771"/>
    <dbReference type="EnsemblBacteria" id="AEB46427">
        <property type="protein sequence ID" value="AEB46427"/>
        <property type="gene ID" value="VAB18032_26771"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26771"/>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136788_5_0_11"/>
    <dbReference type="OMA" id="QFARSWR"/>
    <dbReference type="OrthoDB" id="2069856at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="11392" checksum="1F87B1E0B913655D" modified="2011-06-28" version="1">MLSILLQVLYLITYLFLIILLARFVLSAVLQYGRRWQPGRGASAGLESVWSVTDPPLWALRRVIPPLRIGTVSIDLASLVLLVILFVLMRFVLEPAIFRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI01</accession>
    <name>F4FI01_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GatB/YqeY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736326.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03050"/>
    <dbReference type="EnsemblBacteria" id="AEB47694">
        <property type="protein sequence ID" value="AEB47694"/>
        <property type="gene ID" value="VAB18032_03050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03050"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_0_11"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="OrthoDB" id="1498741at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="15758" checksum="0D965C0ADF6FABCC" modified="2011-06-28" version="1">MSTLKDRLTADMRAALKARDELTTSTLRMALAAVGTAEVAGKAKRELSDDEVLAVLTKEAKKRREAATAFSDAGRTEQAAKETAEGEVLERYLPQQLSDAELTDLVAGALAAGGFTGKAQMGPAMKAAQAAVAGRAEGGRVAAEVRRQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI42</accession>
    <name>F4FI42_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
            <plasmid evidence="1 2">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713128.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30214"/>
    <dbReference type="EnsemblBacteria" id="AEB48006">
        <property type="protein sequence ID" value="AEB48006"/>
        <property type="gene ID" value="VAB18032_30214"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30214"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067299_0_0_11"/>
    <dbReference type="OMA" id="HPGRANE"/>
    <dbReference type="OrthoDB" id="1359757at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB48006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="28734" checksum="3A522DE76D90BB30" modified="2011-06-28" version="1">MRVLVASDPGSVGRDNEDWVHADERLVAVLDGATARTETGCIHGVTWYAHRLGSTVVDLARDCSTPLPQALAEAISRVAAEHQDTCDLDHPGTPSAGIGLARFRPGGLEYLVLGDVSLVIDQGGKLNVVTDDRVSRTAAAERAEADRHPIGSPGKTAALLAMKHAELAARNVPGGYWIAEADPKVVEHALTGSCQVSEQTRVAVLSDGAARAVTLGLLSWPNALELLRADGPAELIALVREAEAEDPQATRWRRNKCSDDATAVYVDGFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI52</accession>
    <name>F4FI52_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30264"/>
    <dbReference type="EnsemblBacteria" id="AEB48016">
        <property type="protein sequence ID" value="AEB48016"/>
        <property type="gene ID" value="VAB18032_30264"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30264"/>
    <dbReference type="HOGENOM" id="CLU_2095862_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="116" mass="10956" checksum="613874908CD234F9" modified="2011-06-28" version="1">MVAAPSRTAGTGAGPAVCGVTAGRGAAGVGSTGTPSRPAAYAANGSAISSGCPLSIAWTDWAATSRPAAVVKVRAAQSTRPVTTTSTSGHVSSPPGAMASTGPGRSGWRATAGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1E0</accession>
    <name>F4F1E0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichyl-phosphate beta-D-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732643.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14320"/>
    <dbReference type="EnsemblBacteria" id="AEB43976">
        <property type="protein sequence ID" value="AEB43976"/>
        <property type="gene ID" value="VAB18032_14320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14320"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_0_11"/>
    <dbReference type="OMA" id="FQVEMNY"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="28338" checksum="98F27C1A6E370343" modified="2011-06-28" version="1">MIEPVQLPSPWRDARLTVVVPTYNEAGNLPTLVERLLALPLPGLKVLVADDNSPDGTGDVADKLAIEHPERVEVVHRPGKEGLGRAYVDGISRALDGGAEYVAQMDADLSHPPEALPGMLGALLSTQAGVVIGSRYVPGGELDENWPLYRRALSGWANLYVHTLLRVRIRDLTAGFKIWRADALRDIGLERVQSNGYSFQVEMHYLATKLGHTILEVPIRFEERRDGISKMTTATKIESALMPFKLRTRHRHIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1T0</accession>
    <name>F4F1T0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27161"/>
    <dbReference type="EnsemblBacteria" id="AEB46505">
        <property type="protein sequence ID" value="AEB46505"/>
        <property type="gene ID" value="VAB18032_27161"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27161"/>
    <dbReference type="HOGENOM" id="CLU_1038064_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="268" mass="29930" checksum="4029BA677823DBCF" modified="2011-06-28" version="1">MGKSLLTAAPDYLVRLRAEKRTASAAALERLGRLPIERFESLGQMTDPKVLETFHEHVCGAHRIIRLSFFESLAEIEGLADLRDRAEAGVEIRVLLGAPKAMKDLRGASHEKRAKRAIRSWREATRNWPNTEVRVAKTTQDIECGSSASIDGSLLRLDVHEPLAERSLMGEMLLAHEAAGNLIRLFDNSFDVAWDRAIPTRRWPLVRRAAGAWRWTATAIVTVPVATALKDSAWRDLLIGVAATSLLAALDENRTRLQIWWGRLTRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1T5</accession>
    <name>F4F1T5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP diphosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_27186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735160.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27186"/>
    <dbReference type="EnsemblBacteria" id="AEB46510">
        <property type="protein sequence ID" value="AEB46510"/>
        <property type="gene ID" value="VAB18032_27186"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27186"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_0_0_11"/>
    <dbReference type="OMA" id="TEIGHNC"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="3">
        <location>
            <begin position="417"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="596" mass="66265" checksum="88D77C47BF5BBDA7" modified="2011-06-28" version="1">MDVDAGRGGALRGALPAQPGELPLARRLRSLLSWPTTDTEPVGQLVRTHRSIHSGADPAVLRRSYTIAENMHRGQFRKSGEPYITHPLAVAQICAELGMDTTTLVAALLHDTVEDTRYTLQALAEDFGHEVAHLVDGVTKFDKAFYGQAAEAETIRKMIIAAGKDVRVLIIKLADRLHNMRTLGVRSAASRERIARKTLEVLVPLCDRLGIQTLKRELDDVVLLHLEPDEHARIARHVHDRPGWDSYLNDVVAQAKVALRRSRVDAQVAPRPRHLYSIWKDTVAGGHTVPYDLPRITVVVDGPATDCYAALGAIHGLWRPVPGRFKDFIASPKNNLYRSLHTSVCGPRDRTVEVLIRTEEMHRSAEYGVAADFRFPRASGAPAARTEQLDWLRRVLDWEQDAADPAQFLQSLRCDLAEAQIQVVADGRQIVLPAGATPVDLAYELGTDRGERCLAARINGRLVPLSSELEEGDVVEIFTETDEECSLDAEVAPRGPRREWLGFVKSPHAQMQINRWFAEHSEPGISISDKVRLGRATIGLALRQHNRGLASDLPLLRLSEELGYPDLETLLVAVFDRVLEPDAVVRQLIDLVDHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1X7</accession>
    <name>F4F1X7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736356.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03200"/>
    <dbReference type="EnsemblBacteria" id="AEB47724">
        <property type="protein sequence ID" value="AEB47724"/>
        <property type="gene ID" value="VAB18032_03200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03200"/>
    <dbReference type="eggNOG" id="ENOG5033ERP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1767285_0_0_11"/>
    <dbReference type="OMA" id="DADEWYA"/>
    <dbReference type="OrthoDB" id="1954122at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="147" mass="14405" checksum="C2A20B8DB1AE72F3" modified="2011-06-28" version="1">MGEQAVTGAADDPTSERTPDADAAEAAATGGPGPTTAGMTADGAAASEVEVPGAGMIADAGGASGPQSRTTDIVPGPGGVMTDEVGVVTGELTLRTEFADGQVTLHVQYKDADEWYVVSGGKAPLDDAAGLDAVHSIAVGLLNRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F214</accession>
    <name>F4F214_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736393.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03385"/>
    <dbReference type="EnsemblBacteria" id="AEB47761">
        <property type="protein sequence ID" value="AEB47761"/>
        <property type="gene ID" value="VAB18032_03385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03385"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069822_0_0_11"/>
    <dbReference type="OMA" id="HEYCALT"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017078">
        <property type="entry name" value="UCP036978_PHPhdr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036978">
        <property type="entry name" value="UCP036978_PHPhdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="353" mass="38411" checksum="D1EB21D0D47660DF" modified="2011-06-28" version="1">MTRDPIADLRRIAFLLERANEATYRVRAFRSAASALAALPAAEVAQRARAGKLTELAGVGDVTARCVAESLAGEEPVYLRRLLATEGTDLDAEASRLRAALRGDCHTHSDWSDGGSPIEEMALAAVELGHEYLVLTDHSPRLKVARGLTADRLRRQLDHVAQLNEALPEGFRILTGIEVDILADGSLDQEEELLARLDVVVGSVHSGLNDDRAKMTRRMLTAVANPHLDILGHCTGRMVSSRPAGVTGPGDRGHRARTRPESDFDADAVFAACVENRTAVEINSRPERQDPPKRLIRRALEAGCLFAIDTDAHAPGQLDWQRFGCERAARCGVPADRVINTWTATDLTAWTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F230</accession>
    <name>F4F230_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736409.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03465"/>
    <dbReference type="EnsemblBacteria" id="AEB47777">
        <property type="protein sequence ID" value="AEB47777"/>
        <property type="gene ID" value="VAB18032_03465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03465"/>
    <dbReference type="eggNOG" id="ENOG5032D4H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1124162_0_0_11"/>
    <dbReference type="OrthoDB" id="1388338at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045642">
        <property type="entry name" value="DUF6406"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19944">
        <property type="entry name" value="DUF6406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="109"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="29804" checksum="18035AD84C97CE7D" modified="2011-06-28" version="1">MRSFTDVATIANNATAILGPARLGVRWVDVGPPVRAEIIVMPSSGEDSAHEVTLGETFPVGEETWRFADLVMSSLDEWEVTVRRVDGSEAPPIGRPWERARLSPYGQLDEAQLQAVEAALGQPLPPDYRDWLRRNNGAQPEVDHHVPGVTFTLMPERPLFGVHPQHPPTDLVPAQRVHRDPWFSPEWLVIARPSGGLLLVSTAQPYDSTVYFLPEQDMVGPISAARERKLRPVAGSMPDLVGRLAPLDVAHLPPAQLAPFGTDIDRDGGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F252</accession>
    <name>F4F252_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731413.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08115"/>
    <dbReference type="EnsemblBacteria" id="AEB42741">
        <property type="protein sequence ID" value="AEB42741"/>
        <property type="gene ID" value="VAB18032_08115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08115"/>
    <dbReference type="eggNOG" id="COG4420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077948_0_2_11"/>
    <dbReference type="OMA" id="IVWMTVV"/>
    <dbReference type="OrthoDB" id="1597938at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="23868" checksum="33851BBAE0CFA811" modified="2011-06-28" version="1">MSEQRRAERLDLPREPRGLKLPRVDQETFGRWAEGIARGMGTANFIVYMTLVICAWFAWNTLAPAGLRFDPYTFTFLTLVLSIQASYAAPLILLAQNRQADRDRVAFDEDRRRATLQKADTEYLAREIAALRIALGEVATRDFVRSELSRLAEELDEAAQRRQRLERRQREGTTGRAGGDGLDEPRDDLDGDHPKDGRRDTDTPHRPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2E3</accession>
    <name>F4F2E3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732682.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14515"/>
    <dbReference type="EnsemblBacteria" id="AEB44015">
        <property type="protein sequence ID" value="AEB44015"/>
        <property type="gene ID" value="VAB18032_14515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14515"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_2_11"/>
    <dbReference type="OMA" id="DRGHEDH"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="716" mass="75952" checksum="056D5D04FD03AE34" modified="2011-06-28" version="1">MAQRSQDKHAAGVPVVTDPAKIRNVVLVGHSGAGKTTLVEALLAATDTIARAGSVTDGTTVCDHDPAAVRQQRSVSLACAPLMHDGIKINLLDTPGYADFVGELRAGLRAADAALFVVSAVDGMDAATAALWEECAAVDMPRAVAVARLDHPRADFDEAVALCQRVFGDNVLPLYLPMLGDDGVSTAGLLGLITRRVFDYTDGLPAQVRQPDPEHLPAITESRDELIEGIIAESEDETLMDRYLGGEEIDAEILIEDLEKAVARGHFYPVVPVCAATGVGVDVLLEVLTAGFPSPPEHALPAVTGVDGSPRPPLTCDPDGPLVAEVVRTTIDRHVGRVCVVRVFSGTLRPDQTVHIAGHGLAERGHPDHDADERIAHLYSPLGATLREVGVAVAGDICAITKSGSAETGDTISAKDDPLLIAPWEMPEPLLPVAIVARSRSDEDALARNLARLVAGDPTMRLERNPQTHQLVLWCMGEAHADVVLDRLRAGGVELDTEPVKVALRETLTAPATGHGRHVKQSGGHGQYAVCDIEVEPLPRGAGFEFVDRVVGGAVPHNYIPSVEKGVRAQMERGLLAGHPVVDLRVTLVDGKAHSVDSSDAAFQTAGALALRDAAAKGRPALLEPVDEVTVRVPDGSVGTVLGDLSGRRGRVLGTESDPESEGRTLVRAEVPATELLRYAVELRAMTAGAGTFRRHFVRYDPMPEHLADQIRKEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2F1</accession>
    <name>F4F2F1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732690.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14555"/>
    <dbReference type="EnsemblBacteria" id="AEB44023">
        <property type="protein sequence ID" value="AEB44023"/>
        <property type="gene ID" value="VAB18032_14555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14555"/>
    <dbReference type="HOGENOM" id="CLU_178398_0_0_11"/>
    <dbReference type="OrthoDB" id="1987032at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="97" mass="11135" checksum="42594F7C9AD30E25" modified="2011-06-28" version="1">MWRPRLGAVRPERLDEHLALLDQVYRELAHTRPPGLRYLSLRLADGHRFIDVVIGPRLPAPLPLLPAFVRYRTGFDERCEDFEMSEVSVSGSYGMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2S6</accession>
    <name>F4F2S6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_21205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21205"/>
    <dbReference type="EnsemblBacteria" id="AEB45341">
        <property type="protein sequence ID" value="AEB45341"/>
        <property type="gene ID" value="VAB18032_21205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21205"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="OMA" id="QWTPMMT"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035277">
        <property type="entry name" value="MalF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="33420" checksum="ABA3B8072B55176B" modified="2011-06-28" version="1">MPDTPGWARWANDHRKWLFAAPAMAFVAALIIFPLAWTIYLSFTDSSGSVRAESEFIGLRNYLDVLTDTDRFWPAVGRTAAFTGAALFFEVVLGMAIALLLWRPFKGEKWVRVAILLPLVATPVAVGMMWRLIFDPNIGMANQILSWVGIGPQPWLAGQNTALPTTIFIDIWQWTPMVVLILLAGLTSLSDEPQEAAMIDGASTWQRFRHVTLPLLMPTVIVAVLLRGIDALKTFDILYATKGRGGGSFNEVETLNVYAYGLSFDYNEYGLSSTVLILFFLIIIGVMWLLTSRKKKEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2V7</accession>
    <name>F4F2V7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735218.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27476"/>
    <dbReference type="EnsemblBacteria" id="AEB46568">
        <property type="protein sequence ID" value="AEB46568"/>
        <property type="gene ID" value="VAB18032_27476"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27476"/>
    <dbReference type="eggNOG" id="ENOG5033C4C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_849775_0_0_11"/>
    <dbReference type="OMA" id="GAYWSAY"/>
    <dbReference type="OrthoDB" id="2092326at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="33592" checksum="57B176EE96A51222" modified="2011-06-28" version="1">MNELERRYRRLLRAYPPDYRRERGDEIIGTYLDVAGPDRRWPSLAEAADLGRGGLRQRLRAAGATDLIPGVRLAGLLALTTAAFLAGFWVFAEQQLPPAEAGVPVFGPFVSVGIVAWCGWLIAALVVAVAPGRPARVAIGVALLMTAAVPAVSVLAGVPRPPLLVVAPMVALGVLALAVDDGLPVPARVLPVTAAVSGGLLSYAMGVGAYWSAYRGGGGEFQPPIGTVLLLVVLLLAIGLGMRRDARGGWAAMALLTPVGLLNVHLLAGAVDGLASGAPRPTYPTMVGVALAVALLGPALLPAAVALRRRLGTPSAAAACPTCGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Y4</accession>
    <name>F4F2Y4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735245.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27611"/>
    <dbReference type="EnsemblBacteria" id="AEB46595">
        <property type="protein sequence ID" value="AEB46595"/>
        <property type="gene ID" value="VAB18032_27611"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27611"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035712_0_0_11"/>
    <dbReference type="OMA" id="GRWQIKH"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014636">
        <property type="entry name" value="RNaseH/PGlycerate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036922">
        <property type="entry name" value="RNaseH_PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="403" mass="41921" checksum="217BA61E152D54FE" modified="2011-06-28" version="1">MAPRTVLVEADGGARGNPGPAGYGAVLRDPATGEVLAERSAAIGTATNNVAEYQGLLAGLTAAVELGATEVEVRMDSKLVVEQMSGRWQIKHPGLRPLAAQAVQLVGRIGTVRFTWIPRDRNTHADALANAAMDAAATSGVAVPSVAPPRVVAPPRELGGPQPAGGGAATVAAHAETPGTDLTSAPVSWEPRPSFTATRLILVRHGETEYTEQGRYSGRGDVALSAKGQAQVRATAARVAALAPQAAAVVSSPLSRCTATAEAIAAAIGDLPVRPDDDLIECDFGAWEGRTFAEVREQWAGELDAWLASTRIAPPDGESFAQVADRCARVTERLVAAYPGQTVVVVSHVSPIKLMLRDALAATDAFLHRLYLDAAGISVLDRWPDGGIAVRTVNDTAHLASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Y7</accession>
    <name>F4F2Y7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735248.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27626"/>
    <dbReference type="EnsemblBacteria" id="AEB46598">
        <property type="protein sequence ID" value="AEB46598"/>
        <property type="gene ID" value="VAB18032_27626"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27626"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118224_0_0_11"/>
    <dbReference type="OMA" id="LYVIACG"/>
    <dbReference type="OrthoDB" id="1429052at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="20461" checksum="4A4303E6284248DA" modified="2011-06-28" version="1">MTGSHRHDGHREVLYIIACGSPLARDVGRLVELAQQDGWDVCVVTTPDGAKFVDRAALARQTGHPVRTHYKNPGDPDVLPSADAIVVCPATVNTVNKWAAGIADTLALGLLIEAQGRGIPLVAVPYTNVAMAAHPAFRTAIDRLTEWGVRVLFGDDVLPLHPPGTGERYQHAFPWPLALTALHDHLVHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F302</accession>
    <name>F4F302_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735263.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27701"/>
    <dbReference type="EnsemblBacteria" id="AEB46613">
        <property type="protein sequence ID" value="AEB46613"/>
        <property type="gene ID" value="VAB18032_27701"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27701"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062440_3_1_11"/>
    <dbReference type="OMA" id="WCERVLQ"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="49"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="28425" checksum="BC680C718DA9E0F6" modified="2011-06-28" version="1">MHGFTDVDRQPDPNSWVGVLDRLAEEPFYRAYQQRVRELLDPTPGRRYLEVGAGTGASAAHLRDAHGVSVATVDRSLTMAAAMRARGLTGCAAADAHHLPFRTHAFDGAWADRTVQHLADPHAAVTDLVRVVRPGGRIVLADPDYDTQVLDIADQELARRVLRFRADALLRNGTLAHRHAGLLAAHGLVDITVEPRTLVVRDPTAVDNVLGLRSWAATAAQRGALDPSEARAFEDQFDEAVRTHRFTYAVTFFLTAATVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F362</accession>
    <name>F4F362_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736473.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03795"/>
    <dbReference type="EnsemblBacteria" id="AEB47841">
        <property type="protein sequence ID" value="AEB47841"/>
        <property type="gene ID" value="VAB18032_03795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03795"/>
    <dbReference type="eggNOG" id="ENOG50336ZI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114123_1_1_11"/>
    <dbReference type="OMA" id="THWWADR"/>
    <dbReference type="OrthoDB" id="1735593at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="143" mass="15196" checksum="8035F163EDE5947F" modified="2011-06-28" version="1">MLADPTGAHAAAFAAVFATLYAAHQVADHWIQTQHQADCKGQPGWSGRLACAAHVATYTGTAVLALVFLIAGTGLRLDPSGVAVGLGISAVTHYIADRRTPLRWIADQLRKSPAWLDKAGGMYALDQSWHVGWLFIAALFCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3V5</accession>
    <name>F4F3V5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4352 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_21530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734059.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21530"/>
    <dbReference type="EnsemblBacteria" id="AEB45406">
        <property type="protein sequence ID" value="AEB45406"/>
        <property type="gene ID" value="VAB18032_21530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21530"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072584_1_0_11"/>
    <dbReference type="OMA" id="FEFQVLG"/>
    <dbReference type="OrthoDB" id="1727679at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307651" description="DUF4352 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="3">
        <location>
            <begin position="52"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="18631" checksum="3E8910376CA1382D" modified="2011-06-28" version="1">MRKTTLIALLATALIGLGCGAGATDEAGDASGGDVAAKSEDKKAEKAEKVAKVGDPARDGKFEFTVKSTKCGVRKVGSDLLGAKAQGQFCLVTLKVKNIGKKSQMFDGSSQKAYAADGTEYSADGAAAIYANENAETFLNDINPGNQVTGVVVFDIPKGVKLTKLELHDSPFSGGVTVALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F455</accession>
    <name>F4F455_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03930"/>
    <dbReference type="EnsemblBacteria" id="AEB47868">
        <property type="protein sequence ID" value="AEB47868"/>
        <property type="gene ID" value="VAB18032_03930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03930"/>
    <dbReference type="HOGENOM" id="CLU_3278342_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="41" mass="4399" checksum="598222B05CEDDFA1" modified="2011-06-28" version="1">MPQRLDTPADPGSRRLEMLAHLAAVSGWADGSPRDGAILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4C3</accession>
    <name>F4F4C3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736568.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04270"/>
    <dbReference type="EnsemblBacteria" id="AEB47936">
        <property type="protein sequence ID" value="AEB47936"/>
        <property type="gene ID" value="VAB18032_04270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04270"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_11"/>
    <dbReference type="OMA" id="GHLFARP"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="406"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="546"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="834" mass="89487" checksum="50D32F24040509BF" modified="2011-06-28" version="1">MTSQDRQTGTDRRLRPLVGLVVVLAGIAGAVSVAHLPNYGVLTATFLWPALISLVTLGFIVKVQVRIRSTNHRIAWTETAIVVGLAVAPSPVVILATGFGVAIASTLIRLPPIKRWFGIGKNMLVATAAGLVLQLFQWPPTNSEITSTIVPLTAAYLAAVLLDELVTLPVIAMATGTSLGKLFREDWDLRLTATVTRLIVIIGTVLTIRTDIRMLLAVPPLVLSLHLFYLTRVRSRTEQQAWQRLAQTTDALNVVELDEVLTTAVTRAAELFSADEVEVELRDAARLVRGNSDGISYDGPTAEAPDATGAVVPAPLEGHDRSIDVGVLRLRFRGSVQLNERERYTLRTFASALCTAVRNAQAYAELARVAQAHAHAAAHDALTGLANRRHLLDEGNEQLHKRHADGVTALVLIDLNHFKEVNDTLGHAAGDQMLIRVAERLRAAARTDDLVARLGGDEFAVLLRALPAPAVAAHRAETLLAALHEPFDIEGMQISVEASGGIAIAPAAGGMVELLRRADVAMYQAKRAGQRVATYAPARDTADLGRLALGGELPRAVADQEFVVNFQPIVDLGTGEVIAAEALARWRHPTHGMIDPLRFLETVERSGLLPAFAEAILDQALIAASTWRDAGFDVPVAVNVSPRSLLDARFPGAVLARLRAHDLPPDRLMLELTETLTLSQLDVVDQVLTRLRDSGVRLALDDFGTGYSSLSLLSRIPVHELKIDRSFVTAMESSAEAAAIVRSTLDLGRSLNLAVVAEGVERDPQRLALWELGCVAGQGHLFARPLAAGALLAALQRGTAGRPGHLATALHDAGAVVRLPPGRRQGGRGRHQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4G0</accession>
    <name>F4F4G0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731589.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09000"/>
    <dbReference type="EnsemblBacteria" id="AEB42918">
        <property type="protein sequence ID" value="AEB42918"/>
        <property type="gene ID" value="VAB18032_09000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09000"/>
    <dbReference type="eggNOG" id="ENOG50329G2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1873070_0_0_11"/>
    <dbReference type="OMA" id="YRIGYRF"/>
    <dbReference type="OrthoDB" id="2179375at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="111" mass="11820" checksum="B9827779FBC93666" modified="2011-06-28" version="1">MSPFLAIFLVLVLAATSYAAGRLHGQLSYRIGYRFGYRQGYFDGDRGAWNRRRRDAQAAIATALAVTGPANARVPAAVAQPGTTYTGSSFTTPTASVTGRHPTGTLVRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4I6</accession>
    <name>F4F4I6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Argininosuccinate lyase</fullName>
            <ecNumber evidence="3">4.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_09130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731615.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09130"/>
    <dbReference type="EnsemblBacteria" id="AEB42944">
        <property type="protein sequence ID" value="AEB42944"/>
        <property type="gene ID" value="VAB18032_09130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09130"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_3_0_11"/>
    <dbReference type="OMA" id="YTNGVAA"/>
    <dbReference type="OrthoDB" id="751464at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="360"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="486" mass="52080" checksum="59EC7318324954A9" modified="2011-06-28" version="1">MTPSLTTYQQHHLRVVFEHHAANLYPAMVKASQAHVVMLAEQGLIPAESAAMMLRGLLVLAQDRPEDLDYDGSVEDVYYTLEKRLAAACGVEPSQLSVQLARSRNDLDAGVFRMVLRDQLLAVLDAVLATGRTVLDRADRHADVVVTGYTHRRPAQPTSIGHVFAGYAEALAGEGVAYADLLDEMNRSPLGSCAFAGTDLDISPRRLADLLGFERLIVNSYEAVAGADHLVRVATLNAQSLATGARLARTLMDWLTWGWVVTPGSFTQGSSIMPQKRNPVVLEHLVSMAGAAAGDAASVLNNVGAAWWEDSNNATTDVQARLWDSDDRAYRFFSLLGGLIAELDPLRPPTSEEIVASGATTTAAADALARHGVPFRGAHSLLGRLVRAGAPATWTVEDVRTAAVDLGIADQLDEVAISDLLAAAVRPEFVLRRAQADGPGEIAVREQVAQLRSIMDDVAARADALRERLHRADAALAEAVAARVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4S6</accession>
    <name>F4F4S6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS3/IS911 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15530</name>
        <name evidence="3" type="ordered locus">VAB18032_15990</name>
        <name evidence="4" type="ordered locus">VAB18032_16730</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013289120.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15530"/>
    <dbReference type="EnsemblBacteria" id="AEB44218">
        <property type="protein sequence ID" value="AEB44218"/>
        <property type="gene ID" value="VAB18032_15530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44308">
        <property type="protein sequence ID" value="AEB44308"/>
        <property type="gene ID" value="VAB18032_15990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44450">
        <property type="protein sequence ID" value="AEB44450"/>
        <property type="gene ID" value="VAB18032_16730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15530"/>
    <dbReference type="KEGG" id="vma:VAB18032_15990"/>
    <dbReference type="KEGG" id="vma:VAB18032_16730"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_11"/>
    <dbReference type="OMA" id="TIDNQQD"/>
    <dbReference type="OrthoDB" id="1839196at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="97" mass="11363" checksum="6341B6427F95E3C2" modified="2011-06-28" version="1">MARQSKYPEEFRRQAAALVLDSGRTIRDVGRELGVNHETLRNWVDRMRQERDGGRPSDLAADERAELVRLRRQVAQLELEKEILKKAAVFFARETER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Z1</accession>
    <name>F4F4Z1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_21900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734133.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21900"/>
    <dbReference type="EnsemblBacteria" id="AEB45480">
        <property type="protein sequence ID" value="AEB45480"/>
        <property type="gene ID" value="VAB18032_21900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21900"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_11"/>
    <dbReference type="OMA" id="PRFIITE"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="230" mass="25552" checksum="38FD67E9398AD244" modified="2011-06-28" version="1">MNRILVVDDEPQILRALGINLRARGYDVQVAATGTDALKAAARHPPDLVVLDLGLPDLDGVEVIRGLRGWTGVPIIVLSGRAGSDDKVTALDAGADDYVTKPFGVDELLARIRAVTRRHTTADTADGRAGSQARVGRHTVDLAERIVTRDDGTEVRLTPTQWGVLERLLRHPGKLITQRQLLQDVWGPEYQNETGYLRQYMAQLRRKLETDPARPRHLITEPGMGYRYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5P9</accession>
    <name>F4F5P9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732926.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15760"/>
    <dbReference type="EnsemblBacteria" id="AEB44262">
        <property type="protein sequence ID" value="AEB44262"/>
        <property type="gene ID" value="VAB18032_15760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15760"/>
    <dbReference type="eggNOG" id="COG2410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123813_0_0_11"/>
    <dbReference type="OMA" id="PFGWPDA"/>
    <dbReference type="OrthoDB" id="1445370at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007362">
        <property type="entry name" value="DUF429"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04250">
        <property type="entry name" value="DUF429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="26751" checksum="FA6796387526F23A" modified="2011-06-28" version="1">MLTLGVDLAAADKRTAMATVEWLPGRAVVRDLILNVDDVRIVEAGGHVDKVGLDCPLGWPEPFVALVQAHRLGHVAVADGEGAQWRRRLAYRLTDEVVREKTGIIPLSVSADRIAHAAFRCAGLLAMLAAAGHDVDRGGGGRVVEVYPAAALYCWGLAHRGYKGRGQQVQHADLVTALRDAAPWLDLGMFEGLCRCSHDAFDSVIAALNARAAAIGLAVQPSDDQRPIARVEGWIALPTGPLSNLIHGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5T5</accession>
    <name>F4F5T5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15940"/>
    <dbReference type="EnsemblBacteria" id="AEB44298">
        <property type="protein sequence ID" value="AEB44298"/>
        <property type="gene ID" value="VAB18032_15940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15940"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033540_2_0_11"/>
    <dbReference type="OMA" id="ERRSHFY"/>
    <dbReference type="OrthoDB" id="895136at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="30782" checksum="8AF5D4A17DAA8C84" modified="2011-06-28" version="1">MDHVVRLRLTSNYRKLAIVIPALLDELHRAQRSSIHARREFTAALLTQAYRAADALADKFGHHDLSARIITMMTKVAQDTSDPTVIGTAQYVRGELFFHNGRPELGRMLLEEAATSISGISQPAGRATYGALHMRAAVLAGLARQPSYAHDHLREASECARRLPDGEYHGTAFGPSSVRIHEVTLALDSGEPDAALRAAAGWVPPASVPSERRSHFYIDLARAHIQTGSPQRAVESLWEARTAAPEHTRIHPHVRDAVSALRPVVASGSSFDEFATWAAGAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F663</accession>
    <name>F4F663_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735464.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28721"/>
    <dbReference type="EnsemblBacteria" id="AEB46815">
        <property type="protein sequence ID" value="AEB46815"/>
        <property type="gene ID" value="VAB18032_28721"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28721"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_4_11"/>
    <dbReference type="OMA" id="GLPCYTE"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="487" mass="49754" checksum="93119011B701239C" modified="2011-06-28" version="1">MAEPHDLTALEQAEAIARGELSSLEVVEHHLRRVDALGDTVGAFVTVTAGQAREAARAADATPPGERGPLHGVSTAIKDLTLTAGVRTTFGSAAFADFVPPVDADVVRFIKAAGLVSLGKTTTSELGCSLYSEGLVAPPARNPWDLSYTAGGSSGGAAAAVAAGLVPVAQGSDGGGSLRIPASLCGLIGYKPSRGLVSSGPLGFGAYGLPSNGPIGRTVADVAALLDVMAAAVPGEPYLPPAPPAGGYLGAARAAAPGRLRVGRFTAAMLVDEPVHPDCVAAVDRAAALLTAAGHEVVEVPPPLGPQVWPLFETLWYVLALTPVPPEGEHLLLPLTRFMRSRGADVSAGTLTTTLGELQVQVRAGVRRTAGCDLLLCPTLSAPQAPVGWFTQGRTPEEDFDRQRRFSPYCAVFNVTGDPSVSLPVGTTAEGLPVGVLLTGRYGADATLIATAAQLEGSCGGWDRHPVLWRGVDSANVSGSGVGRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6R8</accession>
    <name>F4F6R8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22465"/>
    <dbReference type="EnsemblBacteria" id="AEB45593">
        <property type="protein sequence ID" value="AEB45593"/>
        <property type="gene ID" value="VAB18032_22465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22465"/>
    <dbReference type="eggNOG" id="ENOG5031W90">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459820_0_0_11"/>
    <dbReference type="OMA" id="AVHCLYA"/>
    <dbReference type="OrthoDB" id="1735354at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045382">
        <property type="entry name" value="DUF6529"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20139">
        <property type="entry name" value="DUF6529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="22332" checksum="7A80252B1F4827B4" modified="2011-06-28" version="1">MSQHRQGNVRTVPRRPPEPDVEVIREFGAAPAPRRRPSMMVPLLVGAGVAVALGVYGRNHTPTGIAVNVAGFSSPLTVKVWLGTGAAFFAVIQLLSALSMWGRLGGFSPSWAGAAHRWSGRIAFLLTVPVAVHCLYALGFDGYDTRTLLHSVLGCFFFGAFATKMLTLPKRGLAGWVLPVLGGVVFVALIGIFLTSSVWYFTTFGIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6T8</accession>
    <name>F4F6T8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polar amino acid abc transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_22565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734265.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22565"/>
    <dbReference type="EnsemblBacteria" id="AEB45613">
        <property type="protein sequence ID" value="AEB45613"/>
        <property type="gene ID" value="VAB18032_22565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22565"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_1_11"/>
    <dbReference type="OMA" id="EWEYIEI"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="28246" checksum="E318CC7738932B33" modified="2011-06-28" version="1">MDPLRTLWETFFDWESMREALPEMITVGLPNTLILAVTAALLGSALGIVLAVAGISRTRWLRWPARVYTDVFRGLPAAATILLIGVGLAPLGMQVWGPNPYPLGILALSLIASAYIGEIFRSGIQSVEATQLEAARALGFSWGEAMRRVIIPQGIRRILPAWVNQLIALIKDSSLVYFLGLLASQRELFRIGQDYAANTGNQSALLLAGLFYLALTVPLTHVVNWIDRRLRHGRPATGPADDDPDDLDLALPGAAGGNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F705</accession>
    <name>F4F705_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735518.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28991"/>
    <dbReference type="EnsemblBacteria" id="AEB46869">
        <property type="protein sequence ID" value="AEB46869"/>
        <property type="gene ID" value="VAB18032_28991"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28991"/>
    <dbReference type="eggNOG" id="ENOG5031YZ8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2343580_0_0_11"/>
    <dbReference type="OrthoDB" id="2085693at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="11331" checksum="2CD040A8AE42A37C" modified="2011-06-28" version="1">MNRRRTGPDHHTEWCARDHRCNLTEHRSAEILVDLPGHARAVLVRVRASDGREHAEIRVRVALADVDPAARRQLGTLLADLRDLVAHAAVTRRPRPGRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F762</accession>
    <name>F4F762_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha amylase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735574.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29276"/>
    <dbReference type="EnsemblBacteria" id="AEB46926">
        <property type="protein sequence ID" value="AEB46926"/>
        <property type="gene ID" value="VAB18032_29276"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29276"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_0_1_11"/>
    <dbReference type="OMA" id="YSTARDV"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="17"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="542" mass="60266" checksum="81334A1C2AF56A93" modified="2011-06-28" version="1">MPAVTTTGWWTEAVIYQIYPRSFSDSDGDGIGDLPGITARLDHLRQLGVDAIWLSPFYPSPQADAGYDVADYRDVEPLFGTLADADDLIAQAHARGLRVIVDLVPNHTSSAHEWFRQALAAGPGSPERQRYIFRDGRGPDGAEPPNDWQSVFGGPAWTRVADGQWYLHLFDTAQPDLNWDDPQVRAEFLDVLRFWLDRGVDGFRVDVAHGLIKQADLADWHEPQEILSGQEVDKPRPPMWDQDGVHEIYRDWRRLLDSYPGERVLVAEAWVEPAERLARYVRPDEMHQAFNFEYLLASWTAPAQYAVITRSLEATDAVGAPTTWVLSNHDVVRHASRLGLPIGTPRPNGIGIGDPQPDTAVGLRRARAATLLMLALPGSAYLYQGEELGLPEHTLMPDEARQDPTWERSGHTQRGRDGCRVPIPWEADAPSYGFGPTDASWLPQPGVWAEYALDRQRDVPGSTYEMYRTALRLRRGHGLGRGTVQWLSSGDEVLTFRNGDVVVLTNFGATGVPLPAGELLHSSAPLDEDASVPTDVTVWVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7B5</accession>
    <name>F4F7B5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_10275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731844.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10275"/>
    <dbReference type="EnsemblBacteria" id="AEB43173">
        <property type="protein sequence ID" value="AEB43173"/>
        <property type="gene ID" value="VAB18032_10275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10275"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_33_11"/>
    <dbReference type="OMA" id="VETRMAF"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="227"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="424" mass="43630" checksum="3BCDCAA7BBEFC336" modified="2011-06-28" version="1">MRARLALLVAAVSVLIVIAFLVPLALLLRTAAEDRATVRATGDAQSLATVVGTADPDTIRLTVDQLVAESGRPVSVFLPDGTVLGSPAAPTPAVELAARGQSLTAETSDGREVVIAVQGRADGTAVIRTVVPYAEMTAGVGRAWLVLALLGVVLVLIGLTVADRLARTLVRPIGELSAVSHRLANAELDARVQPAGPAELREVGGALNHLAGRIQELLVQEREQVADLSHRLRTPLTALRLEAESLRDPQDAARITEAVDGLERAVTGLIRQARWRTPADGAVATDAVATVAERVAFWSVLAEDTGRAVDLNLAPGPLPVGVPADELAAAVDALLGNVFAHTPDGTAFAVRLAPTGHHVALTVADEGPGIAADSVRRGASQAGSTGLGLDIARRAAQASGGRLELGERPGGGAEVTLLLGSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7M5</accession>
    <name>F4F7M5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733121.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16800"/>
    <dbReference type="EnsemblBacteria" id="AEB44464">
        <property type="protein sequence ID" value="AEB44464"/>
        <property type="gene ID" value="VAB18032_16800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16800"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165504_0_0_11"/>
    <dbReference type="OMA" id="REWHDEE"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="115" mass="12350" checksum="4152F7FEA78846BC" modified="2011-06-28" version="1">MLAGTGQNVWVAGSGVVRIYHGDEGWGVIDGAEVPGGCWVHFSAIAMNGYRQLAAGQGVSFIAEPMAQDGFAYRAVKVWTTETEPLDEQSESAQSRAYHSTMTLAFDEPPERGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7N6</accession>
    <name>F4F7N6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA (Adenine-n(1)-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22865"/>
    <dbReference type="EnsemblBacteria" id="AEB45673">
        <property type="protein sequence ID" value="AEB45673"/>
        <property type="gene ID" value="VAB18032_22865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22865"/>
    <dbReference type="eggNOG" id="COG2519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="336" mass="36430" checksum="713F3B7F70E41763" modified="2011-06-28" version="1">MTVTHSHPATPGDAVPAETPELPPVHRGPFRPGDRVQLTDPKGRMHTVTLEPGKQFHTHRGILAHDELIGLPDGSVVTTSGGGTAFLALRPLLSDYVLSMPRGAQVIYPKDSAQIVAMGDIFPGAKVLEAGAGSGALSCSLLRAVGTSGELHSYELRDDFAQIARRNVEAFFNGPHPAWHLHVGDVGECTETGFDRIILDMLAPWENLDMVERALLPGGVFIGYVATTPQLSELVEALRERGGWTEPRAWESLVRDWHAEGLAVRPDHRMIAHTAFLVSARKLAPGVTAPPRRRKPSKGTEAYVQRRQALREAEAARQASTASQTQPDTTQETGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7T4</accession>
    <name>F4F7T4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23105"/>
    <dbReference type="EnsemblBacteria" id="AEB45721">
        <property type="protein sequence ID" value="AEB45721"/>
        <property type="gene ID" value="VAB18032_23105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23105"/>
    <dbReference type="eggNOG" id="COG1801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_0_1_11"/>
    <dbReference type="OMA" id="GHSDKWT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="286" mass="33103" checksum="69AC845B46191625" modified="2011-06-28" version="1">MGTASWTDRTLLDSGWYPQTADTPEKRLAYYARQFPLVEVDATYYSPPAERTARLWAERTPPGFTFNIKAFSLLTGHPTKVSAIYKDLRPATDKRNLYPDDLPPQAYEEVWTRFLSALDPLVETGKLGALLFQFPPWFTIRRNNKQYLLEVTRRCAPLRPVFEFRHASWFDGDNATETLDFLREHQLAYVGVDMPQGHRSSVPPVLAATSDLAVVRFHGHSDKWTSRDIHEKFGYRYSKRELADWAPRLRELADQTQQTHVLMNNCYRDYAQVNAQQLQALLTESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7T5</accession>
    <name>F4F7T5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TraR/DksA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_23110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734374.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23110"/>
    <dbReference type="EnsemblBacteria" id="AEB45722">
        <property type="protein sequence ID" value="AEB45722"/>
        <property type="gene ID" value="VAB18032_23110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23110"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_3_0_11"/>
    <dbReference type="OMA" id="TYGFCEG"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="14618" checksum="73C4C3242F87D187" modified="2011-06-28" version="1">MLVHDTVGTGRSQAEIDQIRLSLQARYAELSEEYEQAVQQSQVLRLVEVGDTAGDDQADSGTKTAERDTAQSLLRTILDRRAQFEHALTRLDEGTYGFCEGCSAPIPVERLEIFPSATTCVACKQTRERRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8D3</accession>
    <name>F4F8D3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16870"/>
    <dbReference type="EnsemblBacteria" id="AEB44478">
        <property type="protein sequence ID" value="AEB44478"/>
        <property type="gene ID" value="VAB18032_16870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16870"/>
    <dbReference type="eggNOG" id="ENOG503367P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3013043_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="56" mass="6660" checksum="5D8B0C4D7A397AB6" modified="2011-06-28" version="1">MYKVVLTEAATVEDLHTWLDAHLLRRLWLSLWLPPQLRQRWKDAFPELATTRSNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8X5</accession>
    <name>F4F8X5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S1 and S6, chymotrypsin/Hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735703.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29921"/>
    <dbReference type="MEROPS" id="S01.494"/>
    <dbReference type="EnsemblBacteria" id="AEB47055">
        <property type="protein sequence ID" value="AEB47055"/>
        <property type="gene ID" value="VAB18032_29921"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29921"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_3_4_11"/>
    <dbReference type="OMA" id="EIWTHKP"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="450"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="546" mass="54393" checksum="1A0D5AB38412AF76" modified="2011-06-28" version="1">MTEYESDPRRPAPTDAEPSHPELPRAEYARSDSPTEPVVGSSADPTAESPTIPVHAVETSPAGNQDAEPTMVGLPVAGMPPPPQTGPSSPAPGQPAQAPDQPAPQAPGQPAPQGQPVAGQHPWGPAGSQPYQPGSRYPAAPWYPGQSGWAGSQQPSPGGHPGYPGQPSAGYPGQPGAQTAGYPGQLPPWAAPQQSVAGPRPGRIAKFVGAGVAVFALMLGSGIAGGTLALALSDGGTVTRTFSAAPVIDGADLPRIAAAVQDSVVSITTGSGEGSGVVLTADGYVLTNNHVIAEGGDTVRVIFANGTNAQADVIGTDPRTDLAVLKANGVSDLKAATFGDSDAMQVGDQVLALGSPLGLQGSVTAGILSARDRTIQAGSGDRLPGQAVSSISGLLQTDAPINPGNSGGALVNTRGEVIGINTAIATAGQGNTGNIGVGFAIPSNKAKDIADKLQRREKISHPSLGVSVTGTSDGGALINAVTPGSAAERAGLERGDVITRFGDKVINDSNDLVGAVQAGKVGDQVEVTFQRNGAEATATVTLAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9G8</accession>
    <name>F4F9G8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733201.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17210"/>
    <dbReference type="EnsemblBacteria" id="AEB44546">
        <property type="protein sequence ID" value="AEB44546"/>
        <property type="gene ID" value="VAB18032_17210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17210"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_1_11"/>
    <dbReference type="OMA" id="DGAPPYE"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="12782" checksum="DF93A3DD83D93602" modified="2011-06-28" version="1">MIVIDAASPTPPYEQLRAQLARQIQDRSLAVGTRLPTIRRLAADLGLAVNTVGRAYRELEEAGLIETRGRAGSFVSAAGVQALDRARSAARDYAAVVTSVGIDPTEAVRIVEAALGVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9H8</accession>
    <name>F4F9H8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733211.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44556">
        <property type="protein sequence ID" value="AEB44556"/>
        <property type="gene ID" value="VAB18032_17270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17270"/>
    <dbReference type="eggNOG" id="ENOG5032YIJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122352_0_0_11"/>
    <dbReference type="OMA" id="RLTWAED"/>
    <dbReference type="OrthoDB" id="1874790at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="198" mass="22144" checksum="1A4CA26BA0051AF2" modified="2011-06-28" version="1">MVTMTTPERRPDDIPTDEDRVDRALRLLCGVPVELGVAVKRLSRGSGVYAWWAAPSVFPDLPGLPNEHVPSLRLLYLGRATSLRGRILRNHLRRSGSSTLRRTLAGLLVTEGYRTTWTDRVVLVPEDETRLTAWMHTHLRLTWAEDAEPATIEAALVRRMHPPLNVHGVDPDHLQATVLAAKNSYNASSRPDEAPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9S7</accession>
    <name>F4F9S7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734505.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23775"/>
    <dbReference type="EnsemblBacteria" id="AEB45853">
        <property type="protein sequence ID" value="AEB45853"/>
        <property type="gene ID" value="VAB18032_23775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23775"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_3_0_11"/>
    <dbReference type="OMA" id="HDLLPGW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTAD" evidence="2">
        <location>
            <begin position="105"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="268" mass="29765" checksum="71EE8739EDF7F4A9" modified="2011-06-28" version="1">MADSPTPTTGKLRDAEVRLHLLGGFRLTHDDTPVVVPRGLQRVIALIGLRPATTRTHLAGLLWPETTEERALSSLRTALWRLRQDPYCPLATNADTVRLDPAVQVDVDKLVDTAGRVRDGQTPADAAQALAAGRHDLLPGWYDEWVLTERERLRQLRLHMLEQVAGHHLVAGRHGEALDAALEAMAAEPLRETPHRLVVRIHLAEGNAFEAVHAFYVYRDLLLRELRLEPSPAMSALLDDTLEPIRRASQAASTSRRYPALRSTQQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9W3</accession>
    <name>F4F9W3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734541.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23955"/>
    <dbReference type="EnsemblBacteria" id="AEB45889">
        <property type="protein sequence ID" value="AEB45889"/>
        <property type="gene ID" value="VAB18032_23955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23955"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_0_11"/>
    <dbReference type="OMA" id="RWPKEPE"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307544" evidence="1">
        <location>
            <begin position="28"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="435" mass="46645" checksum="D3763D43C16E0FFC" modified="2011-06-28" version="1">MAIKRRVRTVLALSITTALLATGCSGGESEEPAESELYKNPVTLTWWHNASEDGPGKEYWQKVAKDFNALHPTVTIEIEGIETNQLQRTRLPAALLSNDPPDIFQAWGGGEIREQVEAGYLKDITEQVKDEVANIGGAAEIWAVDGKQYGLPFRMGIEGIWYNKDMFAKAGITAPPTTFDELNEAVTKLKAINVVPIAVGAGDKWPAAHWWYNFALRACSVDTLKKAAKDLDFEDPCFLKAGEDLKAFIDTKPFQNNFIATPGQNDPTSANGLLANGKAAMELMGDWNKGTLDNVAEDQEALNKFIGWFPVPAISGSPGDPKAALGGGDGFACAKNAPAECVEFLKYLVSPEVQKGYAETGQGLPAAKGAEDGVKDPALRSILEATTSATYVQLWLDTAFGSTVGNAMNDGIVAIFAGNGTPQQVVDAMKSAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9X2</accession>
    <name>F4F9X2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_24000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734550.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24000"/>
    <dbReference type="EnsemblBacteria" id="AEB45898">
        <property type="protein sequence ID" value="AEB45898"/>
        <property type="gene ID" value="VAB18032_24000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24000"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OMA" id="RIDFTPY"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="32891" checksum="42E10FE111E4835F" modified="2011-06-28" version="1">MVANTLAPPVAARPQRSRSRSWLRLIILLAIVAVVLYPLIWMIGTSVKSQQEIVSNIGLLPERFTPGNYTDGWSNFDVSFGRFFLNSAMVSLLTVVGNAVSCLLAAYAFARLRFRLRRLWFAIMIGTLLLPAHVLIVPQYILFRTLGLVGGDWPYLPLLIPQFLATEAFFVFLMVQFMRGIPRELDEAARIDGAGAFGIFRHVILPLSRPALVTTAIFSFIWTWNEFFRQLVFLSELSDYTVPVALTLFIDSTSQSAIGPMFAMAVLSLLPVFVFFVAFQRMLVEGINTSGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Y0</accession>
    <name>F4F9Y0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_00035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735738.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00035"/>
    <dbReference type="EnsemblBacteria" id="AEB47091">
        <property type="protein sequence ID" value="AEB47091"/>
        <property type="gene ID" value="VAB18032_00035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00035"/>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_6_2_11"/>
    <dbReference type="OMA" id="FPARYNI"/>
    <dbReference type="OrthoDB" id="1718602at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="236" mass="25495" checksum="211F9224530B4824" modified="2011-06-28" version="1">MCGRYATTRSSGELSGLFEATDETEGALVVDYNVAPTDPVPLVRLDAQGHRALSLGRWGLLPAWSRSPANAARMINARAETVATSRAYAPAFARRRCLVPADGWYEWVRRPDGSKQPYYMTSTDDPVLAFAGIWSVWEGPSGPLLTLSVVTTAALGELAEVHDRMPLLLPRQRWATWLGPSDDPASLLAPPPLEWLAGVEIRPVGPGVGNVRNDGPELIARVPSMPAAEPADVTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAA7</accession>
    <name>F4FAA7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05210"/>
    <dbReference type="EnsemblBacteria" id="AEB42168">
        <property type="protein sequence ID" value="AEB42168"/>
        <property type="gene ID" value="VAB18032_05210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05210"/>
    <dbReference type="eggNOG" id="ENOG5033VMW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1202778_0_0_11"/>
    <dbReference type="OMA" id="TMSEHIA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="223" mass="24219" checksum="7340010ACC8AA3AF" modified="2011-06-28" version="1">MVNVELAELPRVTSVAAHVRFASGAYGRGFQIGPRGYHEFACTYMVAANPVDRLLVHGREVVVSESLDKHTSVATLIGDYHELMTVFGGPAPRRERLVELFATLEIADQVRGMVVRPRRETLLGTMSEHIALFAEGLGSLSIPGPAHAASLQPRHQGARTMFGEVWRSPLPGVTSAAQLTDYTYTLGFPSAMAEVVFADADDAVTDADKLAWLEQINISWTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAA9</accession>
    <name>F4FAA9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05220"/>
    <dbReference type="EnsemblBacteria" id="AEB42170">
        <property type="protein sequence ID" value="AEB42170"/>
        <property type="gene ID" value="VAB18032_05220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05220"/>
    <dbReference type="eggNOG" id="ENOG503425E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1467629_0_0_11"/>
    <dbReference type="OMA" id="NTYFTIC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="184" mass="19842" checksum="7FD734133A255599" modified="2011-06-28" version="1">MTLTFEQIPDLSVAAPEAPRSRALTRLRVQPQRRTVLRGIAFSALAVGGFVASATSRFSSPAHAETGPGGLTGWDRNDCKDAFPNGYSPQKDNVGSHTARAAACFGGAYRGSTYCASGWHRSGTVRDEPVTYTYKPVSNSCGATTKKNAWRWTTPDGVWWRCSDGNTTVSAGGTTNTYFTICRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAH3</accession>
    <name>F4FAH3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmB</name>
        <name evidence="6" type="ordered locus">VAB18032_11420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007075181.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11420"/>
    <dbReference type="EnsemblBacteria" id="AEB43400">
        <property type="protein sequence ID" value="AEB43400"/>
        <property type="gene ID" value="VAB18032_11420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11420"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_11"/>
    <dbReference type="OMA" id="RINVCTS"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="63" mass="6721" checksum="BF5EF31BBDC411CE" modified="2011-06-28" version="1">MASVCDVCGKGPGFGHNVSHSHRRTNRRWNPNIQSVRTPAGGGTTKKLKVCTSCIKAGKVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAK8</accession>
    <name>F4FAK8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase I</fullName>
            <ecNumber evidence="3">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_11605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11605"/>
    <dbReference type="MEROPS" id="S26.025"/>
    <dbReference type="EnsemblBacteria" id="AEB43435">
        <property type="protein sequence ID" value="AEB43435"/>
        <property type="gene ID" value="VAB18032_11605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11605"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_0_1_11"/>
    <dbReference type="OMA" id="VAKPFYI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="31"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="32794" checksum="3BBB24F64636C6E9" modified="2011-06-28" version="1">MRVVQALDDSGSVDPWRRRSRRNKPQMPLWQELPLLLVVAFCLAVLIRTFLLQAFFIPSGSMEDTLLVGDRVLVNKVVYNVRDPQRGEVVVFRGTDKWVPQVEVEPADGFVDRLGRTVGDLVGLSRPGEKDFIKRVIGLPGDRVSCCDDQGRLLVNGTPLDESAYVLRDSPLDLPPNAQECRSRRFEEIVVPPGQMFVLGDHRLVSQDARCQGTVPIDNVVGRAFAVVWPSNRWHTLPIPETFADVPSPVTATGGAAPAVRPTAEGGAFLALPIAAVLSVLARSTRWHRSGQRRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAL2</accession>
    <name>F4FAL2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17625"/>
    <dbReference type="EnsemblBacteria" id="AEB44627">
        <property type="protein sequence ID" value="AEB44627"/>
        <property type="gene ID" value="VAB18032_17625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17625"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052605_1_0_11"/>
    <dbReference type="OMA" id="ASHFFPQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307761" evidence="4">
        <location>
            <begin position="39"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="31095" checksum="E1DB4FC5D90CA7C5" modified="2011-06-28" version="1">MRSTTTTRPRSLTLLARLAMTAVLAAGGVVATSSAAQAANPYERGPAPTNAILEASRGPFATSSTTVSSLVSGFGGGVIYYPTTTTAGTFGAVAISPGYTASWSSLDWLGPRIASHGFVVIGIDTITRLDQPSSRGRQLLAALDYLTERSSVRSRIDSSRLAVAGHSMGGGGSLEAAASRPSLQAAVPLAPWNLTKNWSNLRVPTLIIGGESDSVASVATHSEPFYNSIPASAEKAYLELNNEGHFFPNTVNTPTAKQMVAWLKRFVDDDTRYDQFLCPGPSGLAVEEYRNTCPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAV1</accession>
    <name>F4FAV1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45914">
        <property type="protein sequence ID" value="AEB45914"/>
        <property type="gene ID" value="VAB18032_24080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24080"/>
    <dbReference type="HOGENOM" id="CLU_3298273_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="40" mass="4117" checksum="DBEACE9F2F93161F" modified="2011-06-28" version="1">MGDRRNLVVVGATLLGVRLGVRVWLGGRVRLDGGTAGPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAZ7</accession>
    <name>F4FAZ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24310"/>
    <dbReference type="EnsemblBacteria" id="AEB45960">
        <property type="protein sequence ID" value="AEB45960"/>
        <property type="gene ID" value="VAB18032_24310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24310"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="KLHAPDR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="22695" checksum="76C5DC1A9417215F" modified="2011-06-28" version="1">MDQIRVLLVDDHAPFRAGLRALLATSADIEVCGEAASGEEALAVSGRLQPDVVLLDLTMPGMGGIAATERLVRMSPHVRVLILSMADDDDSVFAALRAGARGYVLKGARRQEIVRSVRVVADGEAIFGPAIATRLMGYFAGLARNEPAFPELTAREREILTLIAQHLTNPQIAARFGLSTKTVRNHVSNIFAKLQVADRAQAISMAREQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB38</accession>
    <name>F4FB38_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735828.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00495"/>
    <dbReference type="EnsemblBacteria" id="AEB47183">
        <property type="protein sequence ID" value="AEB47183"/>
        <property type="gene ID" value="VAB18032_00495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00495"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_11"/>
    <dbReference type="OMA" id="LMFAGQG"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="99"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="312" mass="33823" checksum="632754C5B123822E" modified="2011-06-28" version="1">MFRFIVRRLLQMVVAFFGTTLIVYALMFAGQGDPIQALAGERPVTAAQRAYLTEKYHLDATGVGGFFYRYFDYLKNLVRGDLGESLTGRSIGEILANAWPVTIKLALIAIAVAVIFGVTAGVLAGIRRGSIFDNSTLLLTLLVLGIPTIVLAPLAQYLLGVKWQLFPATSGADPSFYALLLPGIVLGSLSLATALRLTRTSVAENLRADYVRTARSKGLPRRRVVSVHVLRNSLIPVITFLGVELGNLMSGAIITEGVFNIPGVGFNLFRAIRTEDGPLVVGIVSVLVVVYLVSNLVVDILYAVLDPRIRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB55</accession>
    <name>F4FB55_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M23B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00580"/>
    <dbReference type="EnsemblBacteria" id="AEB47200">
        <property type="protein sequence ID" value="AEB47200"/>
        <property type="gene ID" value="VAB18032_00580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00580"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_3_3_11"/>
    <dbReference type="OMA" id="WKGESIN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="138"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="25473" checksum="681D829D780FD8AB" modified="2011-06-28" version="1">MQDDNSTPYRKIPNAPVRHRRQVGWRDRGLVIGAVALVGLGGVAVATRDGQPTPSPVSLDAQAEAEAARIAAAARADRSARDLVAPSATNSPTPTPSASASPTAKPSPKATKSATSGWVIPMAGAAITSCYGPRWGTLHAGIDFALPAGTPVRAAFGGTVTKAGDVGDGYGISVVIDHGNGYLTHYAHLSTARVSVGEKVSTGQTIGLEGSTGDSTGPHLHFEVHQGQMWNQIDPAPFLRARGINVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB99</accession>
    <name>F4FB99_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="2" type="ordered locus">VAB18032_05345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730869.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05345"/>
    <dbReference type="EnsemblBacteria" id="AEB42195">
        <property type="protein sequence ID" value="AEB42195"/>
        <property type="gene ID" value="VAB18032_05345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05345"/>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_3_1_11"/>
    <dbReference type="OMA" id="LHFVCRD"/>
    <dbReference type="OrthoDB" id="1527083at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="23725" checksum="3F69974D3788F067" modified="2011-06-28" version="1">MTARVGVVTFPGSLDDGDAARAVRIAGAQPVRLWHGDPELHGVDAVVLPGGFSYGDYLRCGAIARFAPVMETIVDAAAGGLPVLGICNGFQILCEAHLLPGALTRNQHLHFRNRDQILRIESAGTAWTNAFQPGQEVLIPVKNGEGCYVADPATLDALEAEGRVVARYVGVNPNGSQRDIAAITNPAGNVVGIMPHPEHAVEALTGPSLDGLGFFTSVLKHLVGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBG4</accession>
    <name>F4FBG4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730933.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42260">
        <property type="protein sequence ID" value="AEB42260"/>
        <property type="gene ID" value="VAB18032_05670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05670"/>
    <dbReference type="eggNOG" id="ENOG5033GGZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186564_0_0_11"/>
    <dbReference type="OrthoDB" id="2050366at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="84" mass="9147" checksum="6EF3780740F9E754" modified="2011-06-28" version="1">MVALQIRDVPEEVRDALAAQAKARGQSLQAYLLELVETQARRLRNTAALDRFAGRSDGARSLPGESAAELDDQREQRGPWGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBN1</accession>
    <name>F4FBN1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate transporter/antisigma-factor antagonist stas</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11895"/>
    <dbReference type="EnsemblBacteria" id="AEB43493">
        <property type="protein sequence ID" value="AEB43493"/>
        <property type="gene ID" value="VAB18032_11895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11895"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_11_0_11"/>
    <dbReference type="OMA" id="CHCCSVD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="104" mass="10873" checksum="50CF41EE1CCA0F55" modified="2011-06-28" version="1">MDQGSAPPVFSAVAETDGDHLIVVVTGEVDMATADTMLQAALREPAARVTLDLRAVTFFDSAAIHAVVRLAGHYPGTLTVLPSRQVTRVLEIAGLGGQPWLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBY8</accession>
    <name>F4FBY8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_24440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734638.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24440"/>
    <dbReference type="EnsemblBacteria" id="AEB45986">
        <property type="protein sequence ID" value="AEB45986"/>
        <property type="gene ID" value="VAB18032_24440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24440"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_11"/>
    <dbReference type="OMA" id="IVTKVWS"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="346"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="583" mass="61110" checksum="3BD78D6230A3EA09" modified="2011-06-28" version="1">MSGLTSTMLPVATGRAALATFWRALRRHPMFGWASIAASLAASAAAVVVPLLLGRLVDLVVAGGTTRSLLLTSAWILGVGFAGAVLTGAARWLVTEWGMRACADLREEVLDHALRMDSARLESAGSGDVASRVTDDVEQVTDSIQLAAGVFTALVTVVVTFVGFTALDWRIAVAFLVVFPVYALSLRRFVPAAKRLYAAERQAAAVRTQRLLTTFGGVRTVHAYGMEQRQSQRVEQASQEAADARLRAVRGFLWFANMMNYAEAIGLTAVLLTGFLLVRAGDSSVGDVTAAALLFHRLFGPLGMLLISFNDIQSAGAALARLVGVTEVDVPAQRTAETPTRGPAGVTAKSVSHRYAAGPTVVHDVSIEIADGESLAIVGASGAGKTTFAAILGGVFPATEGAVWLGGRLIDDLGPDELRRTVGVVTQEVHVFAGTLADDLRLAAPHATDEQLHAALRLVGAHGWVAALPDGLATPVGDGEHPLTPGQAQQLALARIVLLDPPIVVLDEASAEAGSAGAQQLELASQAVIRGRTAIVVAHRLTQAHACDRVAVMSGGRIVELGRPDDLVAAGGRYAELWAAWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCB1</accession>
    <name>F4FCB1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsM</name>
        <name evidence="8" type="ordered locus">VAB18032_01030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735933.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01030"/>
    <dbReference type="EnsemblBacteria" id="AEB47290">
        <property type="protein sequence ID" value="AEB47290"/>
        <property type="gene ID" value="VAB18032_01030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01030"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_11"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="14313" checksum="54F4478AB0CC38D6" modified="2011-06-28" version="1">MARLVGVDLPREKRLEIALTYIFGVGRTRALETLAATGISPDKRARDLTDEELVQLRDHIEANYKVEGDLRREVAADIRRKVEIGCYEGIRHRRGLPVRGQRTRTNARTRKGPKRTVAGKKKPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCH7</accession>
    <name>F4FCH7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730977.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05890"/>
    <dbReference type="EnsemblBacteria" id="AEB42304">
        <property type="protein sequence ID" value="AEB42304"/>
        <property type="gene ID" value="VAB18032_05890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05890"/>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_2_1_11"/>
    <dbReference type="OMA" id="TSLTPCM"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="97"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="30319" checksum="D2CE642E05F937EC" modified="2011-06-28" version="1">MGETFGQLAVSGPLLLAVGAAALAGLVSFLSPCVLPLMPGYLSYVTGLAGADLEGRGARKGTLLTPAVEEGTPVNTATSAAAAERGGGVGTVVRAERVRAGVKGRVLAGTLLFVVGFTVVFVCTAILFSTIGRVFFDYKRPLEIVIGGLVVLLGLGYLGVLPGLQRELRINRLPSAGLLGAPVLGAVFALTWVPCTGPTLAAVLGMAATSGQTDRAVVLAVAYCLGLGIPFVVFGLGFNRLLGVFQAIRRNSRWVTRVGGVLLIMIGLALVTGGWTNVVIWLQTTIGVGDFQVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCK2</accession>
    <name>F4FCK2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Abc-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_06025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731002.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06025"/>
    <dbReference type="EnsemblBacteria" id="AEB42329">
        <property type="protein sequence ID" value="AEB42329"/>
        <property type="gene ID" value="VAB18032_06025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06025"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_5_2_11"/>
    <dbReference type="OMA" id="GAVELMW"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="8"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="245" mass="26039" checksum="782BDBCDE1C64358" modified="2011-06-28" version="1">MQLALVHARYQLLETVRIPVAIFGSAFFPAAAMLFFVVPFAGKDAVGATYATAAMVTFSVMSANIFQYGVGVAEDRDQPWNPYTRTLPAGSAPRFAGRVMAGLVLTYLSLVPVVVIAATLTEARIDPASFLLALVTVTVISVPFTLMGLTIGYSLPSKAAIVVAQLVFFPLAFGGGLLSAPDQAPGFIEAIAPYLPTRGAVELMWAAVGDYSVNLLSLVMLGVWVVVLAALAGWAYRRDEGRRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCM2</accession>
    <name>F4FCM2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase subunit E</fullName>
            <ecNumber evidence="8">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_06125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731022.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06125"/>
    <dbReference type="EnsemblBacteria" id="AEB42349">
        <property type="protein sequence ID" value="AEB42349"/>
        <property type="gene ID" value="VAB18032_06125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06125"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054537_0_0_11"/>
    <dbReference type="OMA" id="SCMICGA"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="345" mass="35922" checksum="34ABA009EC350CEF" modified="2011-06-28" version="1">MTTVFTDETRARAREIIARYPADRSRSALLPLLHLVQSEEGYVSPAGVAFCAEVLGLNKAQVGAVASFYTMYKRRPTGDYLVSVCTNTMCNVLGGQEVYDTLAEHLGVGHDETTEDGKITLEHAECLAACDYGPVMTVNYDFFDGVDPQGAVGLVDELRAGNRPTPSRGARLCTLKEMSVQLAGFADEREGAVADGVPGEPSLRGLRLAQQHGVSAPGFDPNTPIRSSKAGDKPAPATPPKAAPTGTTAPDVAAPDRKSPQLRTAETRQPDAKTAVPDAPGTKVPTDGAAPGPRDAQAAEAAGVAANKPASDAKPAGDDAEAQERNLSEAESTGRGSANDKGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCS3</accession>
    <name>F4FCS3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12265"/>
    <dbReference type="EnsemblBacteria" id="AEB43567">
        <property type="protein sequence ID" value="AEB43567"/>
        <property type="gene ID" value="VAB18032_12265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12265"/>
    <dbReference type="eggNOG" id="ENOG5033029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093866_0_0_11"/>
    <dbReference type="OMA" id="VVRRFHY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="19195" checksum="C7036D34A1F95E58" modified="2011-06-28" version="1">MVDGAKVASHRVEGSDARITLAAGAVSTVLLHVLRRFHYEVGAVGRGDLIGHRTTRAVVAAFESNYLSGTAVAIRPNFYPVGSAGNFFTGEMLVIRDILAECDGVVRWGGDDRDHPSEGHFQIDVPPGDTRLDRLARTFEEWADQPDRGPGTMIDLLNARRRSAAKDLRARQRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCT3</accession>
    <name>F4FCT3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Binding-protein-dependent transporter inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_12315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732246.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12315"/>
    <dbReference type="EnsemblBacteria" id="AEB43577">
        <property type="protein sequence ID" value="AEB43577"/>
        <property type="gene ID" value="VAB18032_12315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12315"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_0_11"/>
    <dbReference type="OMA" id="YRVIETW"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="224" mass="23990" checksum="322E61E1FD009D15" modified="2011-06-28" version="1">MHVFSDPKNFDAFVSSFLWILKLTGASAVGALVLGVLLAAMRVSPVPVLRGFGAAWVNIFRNTPLTLVIFFCYFGLFVTLGLSLSQDLFLNIYWLGVIGLSTYTAAFVCEAVRSGINTVPTGQAEAARAIGLTFAQTLRIVVLPQAARSVIAPFGSILIALCKNATIVGTIGLMESSSVMKDLINFNGDAVIPIFLVFAGTFAAILIPTGYFFGWLANRLAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCT9</accession>
    <name>F4FCT9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="14" type="ordered locus">VAB18032_12345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12345"/>
    <dbReference type="EnsemblBacteria" id="AEB43583">
        <property type="protein sequence ID" value="AEB43583"/>
        <property type="gene ID" value="VAB18032_12345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12345"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_2_11"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="130"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="11">
        <location>
            <begin position="374"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB43583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="491" mass="53086" checksum="71879746E2729F87" modified="2011-06-28" version="1">MNVHDSERISGLLEQAGYVRAGESDDSPDVVVFNTCAVRENADNRLYGNLGHLRPVKDRHPGMQIAVGGCLAQKDRGDIVRKAPWVDVVFGTHNIGSLPVLLERARHNAAAEVEILESLDVFPSTLPTRRESTYAGWVSISVGCNNTCTFCIVPALRGKEKDRRPGDILSEVRALVDEGVLEVTLLGQNVNSYGVAFGDAGEPNWKRSGGRSAFAQLLRACGDIDGLERVRFTSPHPKDFTDDVIAAMAETPNVCHSLHMPLQSGSDDVLRAMRRSYRAERYLGIIDKVRAAMPDAAITTDIIVGFPGETEADFERTLDVVRAARFSSAFTFQYSKRPGTPAATMDGQLPKQVVQERYERLIACVEEITWAENKKLVGEAVEVLVAVGEGRKDERTGRLSGRARDGRLVHFDAGSYAGAIRPGDIVHTVVTYAAPHHLNADGEPLSHRRTRAGDAAEAGRSARTPGVLLGLPTIGAPAAAPEPTTGCAVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCV0</accession>
    <name>F4FCV0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_12400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12400"/>
    <dbReference type="EnsemblBacteria" id="AEB43594">
        <property type="protein sequence ID" value="AEB43594"/>
        <property type="gene ID" value="VAB18032_12400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12400"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_0_1_11"/>
    <dbReference type="OMA" id="WACADPG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="12">
        <location>
            <begin position="45"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="149"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB43594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="954" mass="103294" checksum="422D647FF68B4442" modified="2011-06-28" version="1">MTTSRTRSKAGAGLKVERVWTTEGVHPYDEVAWERRDVVMTNWRDGSINFEQRGVEFPESWSVNAANIVTTKYFRGAVGTPEREWSLRQLIDRVVTTYRTAGEEYGYFASPADAEVFAHELTWMLLHQVFSFNSPVWFNVGTPSPQQVSACFILAVDDSMDSILDWYKEEGLIFKGGSGSGVNLSRIRSSRELLSSGGTASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEEFVVTKAREEDKIRALRDAGFDMDLGGADIVSVQYQNANNSVRVSDEFMTAVENGGGFDLRGRLDGQTIETIDAKKLFRTISQAAWECADPGLQYDDTINDWHTCPETGRITASNPCSEYLHLDNSSCNLASLNLMKFLRADGGFEVEKFVKSVEFVITAMDISICFADFPTEKIGETTRAYRQLGIGYANLGALLMASGLPYDSDQGRSLAAAITSLMTGTAYRRSAELAGIVGAYDGYARNAEPHKRVMRKHAAANDEIKPTGTVATAVVREATRQWTQGNKIGDKFGWRNSQASVLAPTGTIGLMMDCDTTGVEPDLALVKFKKLVGGGSMQIVNQTVPRALRSLGYPEEQVEAIVEHIADHGHVVDAPGLKPEHYPVFDCAMGERSIAPMGHVRMMAAVQPFISGAISKTVNMPEQATVEDVEKIYFEGWKLGLKALAIYRDNCKVGQPLSVAKPNKAAEPAPTTAVEPVVEKVVEYRPVRKRLPKKRPSETISFSVGGAEGYLTASSYPDDGLGEVFLKMSKQGSTLAGVMDAFSVAISIGLQYGVPLETYVSKFTNMRFEPAGMTDDPDVRMAASVMDYIFRRLALDFLPYDRRAELGIFTAKERAAQLAAEAEAEANGTDLTAMASSAPVETRPEEPKAGPIAQPAQELADVAAAKPAPSVGSSTELLEAVIGKAADAPLCFTCGTKMRPAGSCYVCEGCGSTSGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCY6</accession>
    <name>F4FCY6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TraG-D_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733473.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18580"/>
    <dbReference type="EnsemblBacteria" id="AEB44818">
        <property type="protein sequence ID" value="AEB44818"/>
        <property type="gene ID" value="VAB18032_18580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18580"/>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029028_2_0_11"/>
    <dbReference type="OMA" id="WGEVGMD"/>
    <dbReference type="OrthoDB" id="246216at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="2">
        <location>
            <begin position="412"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="587" mass="63349" checksum="48A3CFD8AF74B6A7" modified="2011-06-28" version="1">MSRQDGIGGDWLPWLIPGFALVNLVVFVPLWLGGTLAALLTGHGWQPPPFTLQVYVRLVSGATQELWPGVPSYLVYGGAVALVLAGAAPLALLVRGFVRRRREPRSLARPRELSAMTGKGLEARARDLRPGLKDVARLHPDDTGNLLGDLVPAGPELRSSYEDVELDLMAPRAGKSTGIAIPRVLRAPGPVLLTSNKSDVFTVTRQERTRVGRVWTFDPQGIAYTERDMWWDMLSGCDTIEGARRLAGHFVSSVNDDSSKKDFWIAAAQNTLTALFLAASRSGATVNDLLAWLADPADRTPVDLLRDVGMTAMADQLQGTVRGAVETRDGIYETARQCVACLLDPEILAWVSPDPYRPQFIPEQHVLGRDTLYLLSKDGGGSAAGVIAGLADSVIRAGVVAAERMGGRLDPPMTAILDEAANVCRISDLPDLYSHLGSRGISVVTLLQSYRQGVRVWGEAGMDALWSAATVKLLGAGLDDADFVDKVARLVGQHDVRTPSYSRSKDGSSRSVSYRQEQVLPADKIRALPKGTALLLATGVRPALIRLRPWFREPNAGPIAAAAKAEVQAITDRAAASWSRRESRQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD15</accession>
    <name>F4FD15_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18725"/>
    <dbReference type="EnsemblBacteria" id="AEB44847">
        <property type="protein sequence ID" value="AEB44847"/>
        <property type="gene ID" value="VAB18032_18725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18725"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2496993_0_0_11"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="86" mass="9410" checksum="0B13FF018EE1D0BE" modified="2011-06-28" version="1">MHRLPRGPVLNSGLRRHGDEAPAVEQALALAALIELSTALGKVDLVPTWGDRLRALPLTAPERDQIRHSIATPDTRTPWLPHPFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDH2</accession>
    <name>F4FDH2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_01495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736018.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01495"/>
    <dbReference type="EnsemblBacteria" id="AEB47383">
        <property type="protein sequence ID" value="AEB47383"/>
        <property type="gene ID" value="VAB18032_01495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01495"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_2_1_11"/>
    <dbReference type="OMA" id="FPYKRLF"/>
    <dbReference type="OrthoDB" id="1841075at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="30190" checksum="7BEB950FCD71701A" modified="2011-06-28" version="1">MDAVILLTLTGLGLAALYFLVASGLSLVFGLADVLNFAHGLFLGVGAYATWWAAGNLPGAGSDGFGFVVAVAFGVAAGTLMAVLVELVLIRPLYSRTIEQVLVTVGLSLAGVALLQATWGADARPFPRPEWTRQVTTILGAQVPNGGLLLIVAAVLVLAAILAFLQWTRYGLIIRAGVENREMVTALGIDVRKAFTLVFAIGGAAAALAGALGSVYFGTVSPQQGGSLLIFAFIVVVIGGMGSVVGSAYAAVAVGLLQQFVNYYGTSGLGDICVVALLAVVLLLRPQGIAGKVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDN4</accession>
    <name>F4FDN4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">topA</name>
        <name evidence="12" type="ordered locus">VAB18032_06365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731070.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06365"/>
    <dbReference type="EnsemblBacteria" id="AEB42397">
        <property type="protein sequence ID" value="AEB42397"/>
        <property type="gene ID" value="VAB18032_06365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06365"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_2_0_11"/>
    <dbReference type="OMA" id="YAQPKQR"/>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="654"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="842"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB42397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="934" mass="101895" checksum="BF0682E9F70DA4D7" modified="2011-06-28" version="1">MPSNAGTTRLVIVESPAKAKTISGYLGPGYVVEASFGHVRDLPRNAADVPAKYKGEPWARLGVDVDNGFHALYVVSADRKQQISKLTKLAKEVDEIFLATDEDREGEAIAWHLVETLKPKVPVRRMVFHEITKPAIQAAVANPREIDRSLVDAQEARRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERQRMAFRTAEYWDILATLAVANAGEGPRTFNATLVALNGDRIATGKDFEPTTGKVRAGAGVVHLDSSGARGLAARLEGRPFTVTRVEEKPYRRRPYAPFITSTLQQEAARKLRFSSQQTMRTAQRLYENGYITYMRTDSVNLSETAIAAARRQIVELYGERSVPPEPRRYTGKVKNAQEAHEAIRPAGDNFRTPGDVAKELSAEEYKLYELIWRRTIASQMTDAVGSSVSVRIRATTTAGEEADFGATGKTITDPGFLRAYVESSDDENAEAEDAERRLPNLVKDQPLTADELAAQGHHTQPPARYTEASLVKALEELGIGRPSTYASIMQTIQDRGYVFKRGQAMIPSFLAFAVIGLMERHYPRLIDYDFTASMENELDEIAGGDHAAVDFLTAFYFGTTNGAGDQDIARSGGLKKLVTENLSDIDARSVNSIPLFTDDEGREVVVRVGRFGPYLQRALPGEQPAPKAEGEEGGTPGDRAPIPEGLAPDELTPEKVHELFLGGGGERKLGDDPATGEPILLKSGRFGPYVASGDRKSSLLRSQSPDSLTLDEALKLLSLPRLIGVAPDGAEVFANNGRYGPYVKRGDEFRSLDSEDKMFTVTLDEALALLAAPKTRQRRAAAPPLREMGADPLTEKPLVIKDGRFGPYVTDGETNASLRRGQTPEELTLEEASEMLAEKRAKGPAPKKTAAKKTTAKKTTAKKAPAKATKATAAKAAKATPAKKAAPKKATSARSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDR7</accession>
    <name>F4FDR7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732267.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12420"/>
    <dbReference type="EnsemblBacteria" id="AEB43598">
        <property type="protein sequence ID" value="AEB43598"/>
        <property type="gene ID" value="VAB18032_12420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12420"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="OMA" id="AQFIVHD"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="208"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="313" mass="33610" checksum="B0AE0A9151AB00BA" modified="2011-06-28" version="1">MHRVVVVANDDVVPFDLSVPIEVFGRARLADGRPAYQVRVCAVTEEVRAGAVGVRIPHDLSVLAEADTVVVPGVADLAAPLPAAIREALATCTARLVSICTGAFVLAAAGRLDGRRATTHWAAAAELARRYPAVTVDPDVLFVDDDPVLTSAGAAAGLDLCLYVVRRDYGAAVAADTARRCVMPLERAGGQAQFIAYEPPVPAGHGIQPLLAWMADNLHRPLTLAEIAAYASMSTRSLSRHFRDQTGTTPMRWLSRHRVRRAQQLLEQTDQPVERVGALVGFASPTAFRECFRHVVGVSPRDYRAAFPPPAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDW6</accession>
    <name>F4FDW6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732315.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12665"/>
    <dbReference type="EnsemblBacteria" id="AEB43647">
        <property type="protein sequence ID" value="AEB43647"/>
        <property type="gene ID" value="VAB18032_12665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12665"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050005_0_0_11"/>
    <dbReference type="OMA" id="HVESCGA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="429" mass="46305" checksum="38371F5F20DAA4FD" modified="2011-06-28" version="1">MTVIDLGDRTEPTEPRRRRRRPPPSRSFLVPVALVVLLVLTGAAPPAPRLQAILPSSLSAQVFLTGGGQIVAVKPVTGVADGSQELLAYRQPERATGAPQQLTALWRTPVGSAQPMVVERVDDSALVFSLTGTDAGVQTMLLDSRTGQLRWRQNGVAVFVASHLILLQTYERQDLDRVAAVDVASGRELWSVSSKAFWPSYHRDPAGIDVVVVTTVDGDVEVLDARSGTRRGRLPADVDDPGDQRYASVIGDLVVVRSSGAVAAYQLDGLARRWRTDVQSVERIYRCGALICAPSAGSGVHLLDPATGALRWTVGEGFDVLHAGDRRALVVDHRQRPPTVATIEAGTGRPRTVDDSWDLVQDFGVVASHPLGTRSIPDVGAVLARLDPADGQPRRIDLLPGAVGNCRHRDGLIVCRRRDGNFGLWQLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDX4</accession>
    <name>F4FDX4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732323.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12705"/>
    <dbReference type="EnsemblBacteria" id="AEB43655">
        <property type="protein sequence ID" value="AEB43655"/>
        <property type="gene ID" value="VAB18032_12705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12705"/>
    <dbReference type="eggNOG" id="ENOG502ZT51">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2686790_0_0_11"/>
    <dbReference type="OMA" id="HQVTARI"/>
    <dbReference type="OrthoDB" id="2190296at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="74" mass="7784" checksum="66C5E78A42679C00" modified="2011-06-28" version="1">MIPALIVFGLLFGRWWRSALTLAALGWPVLLVASGVEEVGPGLLAAAGLAVLNTAVGVLIHQGVLLVVRRRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDZ0</accession>
    <name>F4FDZ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43671">
        <property type="protein sequence ID" value="AEB43671"/>
        <property type="gene ID" value="VAB18032_12785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12785"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_34_6_11"/>
    <dbReference type="OMA" id="SSAMIIE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="147" mass="16216" checksum="0D8A4C2FCA085A38" modified="2011-06-28" version="1">MIFRAAIRADLPAVLDLLADDMLGRTRDVGEVDATYEKAFADITADPRNHLVVAEAGGEVVGCMQLTYIPGLGRQGAERQLIESVRVRSDRRGQGFGRLMMTWAIDQARQRGCGLVQLTTDKSRHDAHRFYLGLGFVASHEGMKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE04</accession>
    <name>F4FE04_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase fad-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733528.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18855"/>
    <dbReference type="EnsemblBacteria" id="AEB44873">
        <property type="protein sequence ID" value="AEB44873"/>
        <property type="gene ID" value="VAB18032_18855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18855"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_20_2_11"/>
    <dbReference type="OMA" id="RRVYTHH"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="14"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="547" mass="59113" checksum="B888D1F99CF86C42" modified="2011-06-28" version="1">MKPAQPAPQPAAADVDVVVVGCGPVGALTANLLGLRGVSTLVVERSTTPHGQPRAFSCDDEALRIYQQVGLLDQIGADLHQPARADYVNAAGRTFATIDFSQVDFGFGHAPLNFFDQPRLEHVLRGGLDRYDHVELRLGTELVSLYQDDDRVHLVLREVATGQSYPVRARYVLGCDGARSTTRAAVRIPLAGASYAEPWLAVSGDVPAEAIRAPHTTFVCDWRRPAFVSPGARGSYRAEFMLQPDETEADMTRPERIAELVEPYVDPARFTVTRAVIYTFHHLIAQRWREGRVFLLGDAAHQMPPFLGQGLCSGLRDATNLTWKLALVLGRDADPALLDTYEVERRGHTAAMADTSVRLGRVFLARSRPAAWLRDTALRAVQTVPRVRRFVRRFEFKPLPAYDRGLFAGGRRHGAVGTMFPQPRVTVAGSTDPVLLDEVLGAGFALLGTAVPAGGSGWPGVPVRTVVVHPAGTGPAATCAEPDDGQVHVVDVDGVIVAWLRRHRCDAVVLRPDRFVYALGSAADDAMLPSLAAALGTPGTVAATRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE49</accession>
    <name>F4FE49_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733573.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19080"/>
    <dbReference type="EnsemblBacteria" id="AEB44918">
        <property type="protein sequence ID" value="AEB44918"/>
        <property type="gene ID" value="VAB18032_19080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19080"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_2_11"/>
    <dbReference type="OMA" id="IMSNLYD"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307662" evidence="1">
        <location>
            <begin position="36"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="86"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="536" mass="55699" checksum="F67F48439A50B264" modified="2011-06-28" version="1">MSVSPRRLRVGASALTALAIISTAACTAGGGGGNASGGSGATTLTVNTSFVLKTLDPGRVYEATGLTAVHALYDTLLTFEGSDVSKPVPALAESYEVSADAKTFTFKLRQGVKFSDGSPLTADDVVFSLNRLKNIKASPAVTVSELSVSKTDDSTVVVTSATANPNVPVVLSMPSTAVINAKVAQENGAKDGEDAAQGDTAQQYLDTNSIGSGPYVLKSYEPESQVVLEANPDYWGDKPKFDRVVLRNMDVQTQKLTMQRAEANEISLDISGKLLEGLPGTLQTSGVQDTVYFLFLNADPAVSAVTADAKFNQALRAAIDYQGIAALYGQGAAPGAGLVAPAFPGALPEGEASTRDVAKAKALLAEAGLTNPKVKFSYPAITYKGVDLGTVATKVQGDVAEAGITLELNPQPLTTFLDEMRGGKMPMGFTPQSLNYPVADSLINNMAPGQPTALRSGWTVDRADAAVVAAGKKVTETLDLAARATAMQEWQRLMNQSSPYIVLASNSSTVVATADLTGADYTAAGWQVDVAAVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEA1</accession>
    <name>F4FEA1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CdiA_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25345"/>
    <dbReference type="EnsemblBacteria" id="AEB46167">
        <property type="protein sequence ID" value="AEB46167"/>
        <property type="gene ID" value="VAB18032_25345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25345"/>
    <dbReference type="eggNOG" id="ENOG5032Y1P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1937242_0_0_11"/>
    <dbReference type="OMA" id="EGHVFDC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004549">
        <property type="term" value="F:tRNA-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13442">
        <property type="entry name" value="CDI_toxin_Bp1026b_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033806">
        <property type="entry name" value="CDI_toxin_Bp1026b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040559">
        <property type="entry name" value="CdiA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18451">
        <property type="entry name" value="CdiA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdiA_C" evidence="2">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="14769" checksum="45B17423FA79A668" modified="2011-06-28" version="1">MENDCADTVAGKGYRVHQNPTGQQVGDARDRTGDRGNPDKDPDYLIEGHVFDCYSPQARTSVRNVWSQVREKVDDEQTQRVVLNLKDWEGDVAALRRQFDKWPIGGLKELAVVTRDGTIRQIVRETERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEA5</accession>
    <name>F4FEA5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_25365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25365"/>
    <dbReference type="EnsemblBacteria" id="AEB46171">
        <property type="protein sequence ID" value="AEB46171"/>
        <property type="gene ID" value="VAB18032_25365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25365"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="FIFRESC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="369" mass="38772" checksum="BF597827A56B6E55" modified="2011-06-28" version="1">MATMQDVARLAQVSVSTVSYVLTGARPISQATRDKVLAAMAELDYQPNAMARGLASRRSRIVGLLLPMDERGLGATETAFVTGAAAGASAAGYHLVLAPIGVGDRDELRRLASQRMFDGALLMEVQLRDPRVDVLRELDVPLVLIGRTADTTGLSYVDIDFDRTVAEAVGHLVDLGHRRIVYVNHSAGTIAEGYGPALRTRDAFAAAMAAHGLEPLMIPAEDSAAGGRTALATALRQAPDLTAILAMNESAVFGLLGELHRRGLRVPDDVSVISMVTSPQVAELATPALTAMNSPGTALGRIAIETLLRHVDGGHREIHQQLLPCALQVRGSSGPPRTAGTAYPGAGGRQRPGPGSRAARRSAATARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEE2</accession>
    <name>F4FEE2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734860.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25550"/>
    <dbReference type="EnsemblBacteria" id="AEB46208">
        <property type="protein sequence ID" value="AEB46208"/>
        <property type="gene ID" value="VAB18032_25550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25550"/>
    <dbReference type="eggNOG" id="ENOG502ZHWE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1531902_0_0_11"/>
    <dbReference type="OrthoDB" id="2185912at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="19101" checksum="B3A2BC340A8D2D7D" modified="2011-06-28" version="1">MADGELPEHARRRQLIRRYVDRKVVWRARIYAAVFVVTLGVTLVDAVVAGGWTWLRALVGIVAGVVVGVAASRMSRLRWDGFEQRVVGRIDAIGVVVLVCYLTFSFLRARIVGLWVPASQVAATSMGLLSGAMLGQILGIRRGLRLLGRRLLAQPTETTATGSPADGDHDRDPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEI6</accession>
    <name>F4FEI6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736063.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01720"/>
    <dbReference type="EnsemblBacteria" id="AEB47428">
        <property type="protein sequence ID" value="AEB47428"/>
        <property type="gene ID" value="VAB18032_01720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01720"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OMA" id="DKMFLDN"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="344"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="382"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="545" mass="58186" checksum="A6565FFD52715889" modified="2011-06-28" version="1">MSATLIVKDLAAGHGDRSLFTGLDLVVAPGDVIGLVGPNGAGKSTLLRTLAGLLPVEAGSVTVSPPGASIGHLPQEPDRRPGETVRAFLARRTGVTGAQAALDAATEALTAGTPGADDAYADALERWLGLGGADLDERAEEVAAELGLTVDLDQEMTGLSGGQAARAGLASLLLSRYDVFLLDEPTNDLDLAGLDRLEQFVTGLRAGTVLVSHDREFLSRTVTRVLELDLHQQQVNQFGGGYGAYLEEREVARRQARAEFEEYADTKASLEARARTQRSWMDKGVRNARRKATDNDKIGRKFRSEASEKQAAKARQTERLIERLDVVEEPRKEWELRMEIAAAPRAGAVVATLRDAVVRRGEFTLGPVNLQIDWADRVAVTGANGSGKSTLLGALLGRLPLTGGQAALGPGVVVGEVDQARGLFLGDVPLLDAFRAAVPDLSPADARTLLAKFGLRAQHVLRPAATLSPGERTRAALALLQGRGVNLLVLDEPTNHLDLPAIEQLESALDSYPGTLLLVTHDRRMLDAVRLDRRLEVTAGRIVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEJ3</accession>
    <name>F4FEJ3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_01755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736070.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01755"/>
    <dbReference type="EnsemblBacteria" id="AEB47435">
        <property type="protein sequence ID" value="AEB47435"/>
        <property type="gene ID" value="VAB18032_01755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01755"/>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_11"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="677575at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="34900" checksum="49152EF1EA991A69" modified="2011-06-28" version="1">MSYPEHRPRRLRRNAAVRRLVAETRPAPAELVVPMFVKEGLTEPRPIGSLPGVLQHTRDSLRKAAVEAVQAGVGGIMLFGVPAERDECGAGGIDPNGILNVAIRDVVSEVGDATVVMSDLCLDEFTSHGHCGLLTPDGSVDNDATLAAYAEMAVAQAAAGVSVVGPSGMMDGQVGAVRRALDAAGYTDVAVLAYAVKYASAFYGPFREAVESSLEGDRRTYQQDPANLRESLREVELDVAEGADMVMVKPALPYLDVVSAVRAAVQVPVAAYQVSGEYAMVEAAAANGWIDREQVMLETLTSIRRAGAQIILTYWAVEAAELLRQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEL4</accession>
    <name>F4FEL4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathionylspermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736090.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01860"/>
    <dbReference type="EnsemblBacteria" id="AEB47456">
        <property type="protein sequence ID" value="AEB47456"/>
        <property type="gene ID" value="VAB18032_01860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01860"/>
    <dbReference type="eggNOG" id="COG0754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059175_0_0_11"/>
    <dbReference type="OMA" id="QWNSLHE"/>
    <dbReference type="OrthoDB" id="692145at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSP_synth" evidence="1">
        <location>
            <begin position="12"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="388" mass="43877" checksum="DDFCC1305C0E8700" modified="2011-06-28" version="1">MRRERVDPRPDWDATIRAQGLVYVDTELPDGGVMSYWDETAAYAFDLAEVLRLEEATEELHRMSVAAAEHVVARNRYAEFGIPRWAAEAVARSLRESPPTLYGRFDLWYDGSWPPKMLEYNADTPTALVEASIIQWYWLEHTRPELDQWNSLHERLVGAWAKIGAGLHDRRVHVVWSNEEETGEDHMTAGYLAETARQAGLDVELLPIQEVGWDGRRFVDRADQPITTCFKLYPWEWMLAEPYGPLALQPGTPTTWIEPAWKLLLSNKALLAVLWELYPDHELLLPAYLDSPRGMSEYVAKPLLGREGASVRIVTATGEINNPGDYGEEGFCYQQFRALPEFAGSRLVLGSWIVDGESAGTGLRESASLITDGYARFLPHYIDAPRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEL5</accession>
    <name>F4FEL5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736091.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01865"/>
    <dbReference type="EnsemblBacteria" id="AEB47457">
        <property type="protein sequence ID" value="AEB47457"/>
        <property type="gene ID" value="VAB18032_01865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01865"/>
    <dbReference type="eggNOG" id="COG5516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087298_1_0_11"/>
    <dbReference type="OMA" id="PCRNAYL"/>
    <dbReference type="OrthoDB" id="1478254at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="20606" checksum="1FF6A85CE691BED4" modified="2011-06-28" version="1">MNFDAYARTGVDLVNARLDGLDDLRSIFPDDNAWMRDEVVERDLAVFRRAQKRLRDVFEYGTSGRDAEAVAELNSLLEAFPVQPRISGHDSSDWHMHVTSRGASVSSEFLAGAVWGLSVWLCEYGSARFGVCADDRCGNVYLDTSSNCCRRFCSERCATRSHVAAHRARKRAAVPTQTDPLTPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEX7</accession>
    <name>F4FEX7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_12875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12875"/>
    <dbReference type="EnsemblBacteria" id="AEB43689">
        <property type="protein sequence ID" value="AEB43689"/>
        <property type="gene ID" value="VAB18032_12875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12875"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056526_0_0_11"/>
    <dbReference type="OMA" id="EDHLMEC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="26343" checksum="92A1ABB8909CBDCA" modified="2011-06-28" version="1">MDVAAYALGVLDEQDMERFEEHLATCWACAAELESMVPVVGLLSDIDAESVTALEQTHTNPVLLDRTLVAMRTHRRRARFRQILATAAAVVVFGGITGVVFSNLADSGTAPQIAGPTSGPVQVPNTGSGDPGDPGVGGNAQEGRKVNVTDPTTGVTATFFLASKDFGTNIAFTLGRLPGPRECRLVVVREDASTEVISTWSVPQGGYGTNSNPQQLSLAAATSSKLDAVKHFQVQEVDGKGAGKPLVTVPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFR2</accession>
    <name>F4FFR2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013288855.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02275"/>
    <dbReference type="EnsemblBacteria" id="AEB47539">
        <property type="protein sequence ID" value="AEB47539"/>
        <property type="gene ID" value="VAB18032_02275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02275"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_0_11"/>
    <dbReference type="OMA" id="GPCANKV"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="67" mass="7378" checksum="1191F8E5C98B7AF5" modified="2011-06-28" version="1">MAQGTVKWFNAEKGYGFIAVDGGQDVFVHFSAIEMDGYKALDDGQRVEFEIAQGQKGPQAERVRVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFS4</accession>
    <name>F4FFS4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/lc7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736184.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02335"/>
    <dbReference type="EnsemblBacteria" id="AEB47551">
        <property type="protein sequence ID" value="AEB47551"/>
        <property type="gene ID" value="VAB18032_02335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02335"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_0_0_11"/>
    <dbReference type="OMA" id="MTLFANR"/>
    <dbReference type="OrthoDB" id="1635683at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="16163" checksum="61918F02F049CE49" modified="2011-06-28" version="1">MTSPHVHENLDHSSHPVGDLSPEARTFNWLLDTFTSSTAGVLEAIAVSSDGLLMAMSAIKDRSNAERLAAVVSGMTSLAGGAASWYALGGLNRVVVDMAEGYLLISAISSGSVLGVVADRSANLGTVAYEMTLFAGRAGSALTPRLIAELKNSVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFX1</accession>
    <name>F4FFX1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-carnitine dehydratase/bile acid-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731224.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07135"/>
    <dbReference type="EnsemblBacteria" id="AEB42551">
        <property type="protein sequence ID" value="AEB42551"/>
        <property type="gene ID" value="VAB18032_07135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07135"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_0_0_11"/>
    <dbReference type="OMA" id="YVIIQPQ"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="397" mass="42980" checksum="7B9E93BC1C63578F" modified="2011-06-28" version="1">MRREEFYREARDDLDGPLHGLTVLDVTKVWSGPLATGLLADMGADVIRVELPYGRDGEVPPEIPGTGLSWFRETVNRNKRSVGLDLRQPADREAFLQLVRDADLVVENYKPGTLDEWGVGYPDCRRVRPDIVFVSITGWGQYGPDIDRPAYDPVVQAASGWMALNGDPAGRPVRAPTFLADELAGLHAAVGALAALTHRDRTGEGQHVDVAMLDSLLASSCGLLTLAATGAPPARWGNQTDFAVPSNVYRCLDGEVYLSVALDKHWRALAETLGRPELARAPGYGRGAQRRQNRVEVDGLVAQWCGSRTVDEVMAAFRAAHLVAERVRTFSEVAADPQVSARDMLQPTVLHNGTVAPLTGPAVKFSRTPTRIRRGAPAAGADSRDVLRDAVTQPDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG25</accession>
    <name>F4FG25_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_13285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732436.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13285"/>
    <dbReference type="EnsemblBacteria" id="AEB43769">
        <property type="protein sequence ID" value="AEB43769"/>
        <property type="gene ID" value="VAB18032_13285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13285"/>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_4_0_11"/>
    <dbReference type="OMA" id="TEIRELW"/>
    <dbReference type="OrthoDB" id="1508841at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="20834" checksum="3E1B262C462459C9" modified="2011-06-28" version="1">MNDDHDAAGAIRFIFEAGVLKRAARTGWWFAGIKHPESIAEHSFRTALIGMMLAAMEGADPARVSMLCVLHDTQETRITDIPHIAKRYLTAAPNTTVTADQVAACPPAVADLINAAVAEYEAGETPEAIVARDADKLECLIQAVEYRHQGIDNVQRWIDSSRTALKTTSAHRLADAALTGQPLAWLTPPPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG40</accession>
    <name>F4FG40_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13360"/>
    <dbReference type="EnsemblBacteria" id="AEB43784">
        <property type="protein sequence ID" value="AEB43784"/>
        <property type="gene ID" value="VAB18032_13360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13360"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084966_0_0_11"/>
    <dbReference type="OMA" id="PNPQMIW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="29490" checksum="BB3B18EAE6258BBD" modified="2011-06-28" version="1">MLRSPRALLLDFGGVLADAPRQSPAPSDLVRRLSDLVGDTVSVEQITTDLTEGGRAYARWRDDSGHLDDPIELPHAQVWADFVTHSWPAPARTAVEDAATPLAYAWAWRPDWQVRPGIPEALHAAAAAGLPMAVVSNALCGAAHRDFLATAGLSDLFAAEFYSDEAGLRKPNPRLAWSAADAIGVPIGECWFIGDTVHRDVACARRAGAGAAILMRSPRTDHEPPHPQLRPDARIDDGHGLVTLLHQSRGTVEGRPERDDGLLGRATAQTPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG56</accession>
    <name>F4FG56_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="5" type="ordered locus">VAB18032_13440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732467.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13440"/>
    <dbReference type="EnsemblBacteria" id="AEB43800">
        <property type="protein sequence ID" value="AEB43800"/>
        <property type="gene ID" value="VAB18032_13440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13440"/>
    <dbReference type="eggNOG" id="COG0829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056339_1_0_11"/>
    <dbReference type="OMA" id="IPFENAH"/>
    <dbReference type="OrthoDB" id="1764668at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="34316" checksum="D1DE88D24E06DA73" modified="2011-06-28" version="1">MTTSLDLVRELAPYQDQPAQLPAAANGKVGMLRLGFERRGDRTILRDLYRQSPLLVQRALYWDEEMPGLPCVMILTTSGGVLQGDRLSMDVDLGPEAQAHLVTQSATKIQEMDANYGTQQQNITLADDAYLEFLPEPVIPFRRSRFVSHTRVRLPASATLLYAEVLQPGRKYYRDGEIFAYDLFSSQLRAERPDGRGLFVEKFVISPGQFPVDRIAMMDRFHVFGNVMLLTDTDRAARVYERTAAPVWDEQTPLASAVSRLPNDAGLVFKVLGQETEPVRAAVRAFCAAAREEVVGCTFPPAFSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG60</accession>
    <name>F4FG60_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13460"/>
    <dbReference type="EnsemblBacteria" id="AEB43804">
        <property type="protein sequence ID" value="AEB43804"/>
        <property type="gene ID" value="VAB18032_13460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13460"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1874275_0_0_11"/>
    <dbReference type="OMA" id="EVRGYGF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="135" mass="14853" checksum="38DAC47617244E1E" modified="2011-06-28" version="1">MGKIIRFDEVRGYGFIAPSAGGEDVFVHANDFGEHRHLVRVGLPVEFEAVDSDRGLKAASVRIVESEPMAVGGERRLRPRVEGDEELCDVLSPTEFTTAVTEVLLRCSPSLTGAQIIAVRERFVEFSRAHGWVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGD2</accession>
    <name>F4FGD2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19840"/>
    <dbReference type="EnsemblBacteria" id="AEB45070">
        <property type="protein sequence ID" value="AEB45070"/>
        <property type="gene ID" value="VAB18032_19840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19840"/>
    <dbReference type="eggNOG" id="COG1626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015270_1_0_11"/>
    <dbReference type="OMA" id="RIPHIVF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="455" mass="49552" checksum="430629FEF393D21A" modified="2011-06-28" version="1">MVEQVVPAIGPGDTPPADTAAGERAALVAVARATLDGNWEHDHTVPSRTLYPHQWSWDSAFSAIGWAHLRPERAWAELTSLFDAQWRDGRVPHIVFNPVVADDAYFPGPAFWATTSVAGTPRTATSGLVQPPVHALAAWHAYRRAPSEPARAALGRLYPRLVAQQHYLSEHRDVGGAGLASIVHPWESGLDNSPAWDEPLAAVPTEEAVLRAYRRRDIVHAAAAHRPTDLDYARYVAIVTAYRAAGYRDEQLADRHPFLVECPLFNAAMGAAESALAHIAREIGADPGPHRQRAAAITTALVDRLYDPTTGTFHARDLRTGRLTRARTVLGLTPLILPDLPTAQVEAILVEAGSPRFGLADRMTRPLPSHDRTAVDFEPLRYWRGPSWMNINWLVRYGLLAHGHPRLAAGLGASMIELAATAGCHEYFHPDTGAGLGSPAFSWTAALLLDLLAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGH1</accession>
    <name>F4FGH1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_26040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26040"/>
    <dbReference type="EnsemblBacteria" id="AEB46306">
        <property type="protein sequence ID" value="AEB46306"/>
        <property type="gene ID" value="VAB18032_26040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26040"/>
    <dbReference type="eggNOG" id="ENOG502ZHDR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1188960_0_0_11"/>
    <dbReference type="OMA" id="WADSYET"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="21566" checksum="F6A5E215F3794355" modified="2011-06-28" version="1">MVALVSVTVAVLATIDHARQREREHNAGPDAVTVTVEAMLPQPDQVADLVSAYGWRNGSAPVGDPDNQSVLLRLRWSGPGQPGTYQVILLDNRLDPPRVVPPSGGWDAAGSTGFNWADSYETLAARYDFLAGAVSRPESSDSLRTPDNLGAVSTRAVAEGDLVALFRMGPAATPLTDPADLLVAVCYVDPTGTPRWAKPVPVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGH7</accession>
    <name>F4FGH7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734963.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26070"/>
    <dbReference type="EnsemblBacteria" id="AEB46312">
        <property type="protein sequence ID" value="AEB46312"/>
        <property type="gene ID" value="VAB18032_26070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26070"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_11"/>
    <dbReference type="OMA" id="DHWIAER"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="29710" checksum="0BAF4FD0B63CBFAD" modified="2011-06-28" version="1">MIIVTGATGRIGRALVDRLDRHAVARRAVVRQPRHVAELGGDVTLADFADPRSIRAALVPGARLLLNGVPGPDFVHQQRSIIDLAAEAGVAQLVKISVRGAAPGALLAQGQHGEIDDHLRASGLPYLILQPVGFMQNLLPEVSFTDGEGRFYGSYGSGPVGYLDARDIADVAAALLTRPVEANATLTLTGPEAYTHQEVAETMTAVLGRPVHYVDLPVAAMAQRLRAAGLPPAFADDLARLMRDVGDGRWADTTDTVQAITGRPPRTLATFIADHATSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGV5</accession>
    <name>F4FGV5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">disA</name>
        <name evidence="13" type="ordered locus">VAB18032_02655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736247.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02655"/>
    <dbReference type="EnsemblBacteria" id="AEB47615">
        <property type="protein sequence ID" value="AEB47615"/>
        <property type="gene ID" value="VAB18032_02655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02655"/>
    <dbReference type="eggNOG" id="COG1623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787128_0_0_11"/>
    <dbReference type="OMA" id="VVRDYVP"/>
    <dbReference type="OrthoDB" id="1139866at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="12">
        <location>
            <begin position="40"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="392" mass="41856" checksum="E57111CAE7C8A8ED" modified="2011-06-28" version="1">MPVDRDTTKPAGATPHARTGAVGSPARPISISVTGGGSAGDPLRANLALMAPGTALRDGLERILRGRTGALIVLGYDKVVEGLCTGGFPLDVEFSATRVRELCKMDGAVVLSSDGTRIVRAAVHLMPDPTIPTEESGTRHRTAERVARQTGYPVISVSQSMRIISLYVNGQRHVLDDSAAILSRANQALATLERYKLRLDEVSGTLSALEIEDLVTVRDAVAVVQRLEMVRRIADEIAGYVVELGTDGRLLALQLDELMAGVDADRTLVIRDYLPTGRKPRTLDEALVELDLLTATELIDLVSVAKAIGYPAASDALDAAVSPRGFRLLAKVPRLPVAVVDRLVVHFGSLQRLLGATVEDLQAVEGVGDARARGVREGLSRLAEASILERYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGW8</accession>
    <name>F4FGW8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="15" type="ordered locus">VAB18032_02720</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736260.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02720"/>
    <dbReference type="EnsemblBacteria" id="AEB47628">
        <property type="protein sequence ID" value="AEB47628"/>
        <property type="gene ID" value="VAB18032_02720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02720"/>
    <dbReference type="eggNOG" id="COG0853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115305_2_0_11"/>
    <dbReference type="OMA" id="MLYSKIH"/>
    <dbReference type="OrthoDB" id="1751990at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5014006842" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014006845" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB47628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="14620" checksum="4F5DA2ED38557775" modified="2011-06-28" version="1">MYRTMLKSKIHRATVTQADLHYVGSVTVDEDLLDAADLLPGEQVAIVDITNGARLETYVIPGRRGSGVIGINGAAAHLVHPGDLVILISYGQMDDAEARTYRPRVVHVDADNKVVDLGADPSTAAPGTAGSPLPNPLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHB7</accession>
    <name>F4FHB7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-ketosteroid-delta-1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732562.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13915"/>
    <dbReference type="EnsemblBacteria" id="AEB43895">
        <property type="protein sequence ID" value="AEB43895"/>
        <property type="gene ID" value="VAB18032_13915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13915"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_2_11"/>
    <dbReference type="OMA" id="TCECRPF"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="13"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="571" mass="60145" checksum="EFA196E139090FFE" modified="2011-06-28" version="1">MSVPRQPRPTSVDLVVIGSGTGLAAALSAHEAGLSVVVVEKSRWVGGSTARSGGAFWIPANPVLTAEGSGDTPERGAAYLEAVVDGSAPEQRWRSFLEHGTATIEMLTRTTPMRFLWARGYSDYHPELPGGTADGRSCECRPLDLKVLGADRARLRPAVLSAPVPMPVTGADYKWLNLMAKTPFRALPRIVTRLAQGLGGLALGREYAAGGQAIAAGLFAGVRRAGIPVWTETALERLLVEGDRVVGAELRHGDTTFAVRAERGVVLATGGFDHDLPLRHTHHHRDLGDWSLGADSNTGDGIRAAQEAGAGTDLMEQAWWFPAVAPVGDAAPSVLLAERSLPGSLMVDGTGRRFVNESCDYMTFGQRVLGLAREGGALPAMWLVFDKRYRNSYVFAGTQFPRAPLPKSWYEAGIAHRAGNPGDLARSMGVDADALSATLARFNQLAAAGVDDDFARGASAYDRYYGDPTVTPNPNLRPLAGTLYAVRVVLSDLGTCGGIRADGLGRALSDTGTPIPGLYAIGNAAANAFGRTYPGAGATIGQGLVYGYIVGRHAAGKLPAADRAPSRQTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHC4</accession>
    <name>F4FHC4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_13950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732569.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13950"/>
    <dbReference type="EnsemblBacteria" id="AEB43902">
        <property type="protein sequence ID" value="AEB43902"/>
        <property type="gene ID" value="VAB18032_13950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13950"/>
    <dbReference type="eggNOG" id="COG0033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_8_1_11"/>
    <dbReference type="OMA" id="DIYKIYA"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="211"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="322"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="488"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB43902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="549" mass="57806" checksum="021107E9A672C491" modified="2011-06-28" version="1">MSSHPRAGQPAQPADLVDVPRLVTAYYAEHPDPADPAQQVSFGTSGHRGSSLRNAFNSDHILAVTQALCDYRQAQGIDGPLFLGRDTHALSAPAAVDALEVLAANEVTVLLDSRDGYTPTPAVSHAIGTHNRGRTAGLADGIVITPSHNPPDDGGFKYNPTHGGPADSDATKWIQDRANAILAAGGKEVRRIPYARARAVDTTGTYDFLGAYVDDLPAVLDLDAIRAAGVRIGADPLGGASVAYWGEIADRHRLDLSVVNPTVDPTWRFMTLDGDGKIRMDCSSPNAMASLIAMRADYQVATGNDADADRHGIVTPDAGLMNPNHYLTVAIAHLFGTREQWGPAAAVGKTLVSSSMIDRVAADLGRPLLEVPVGFKWFVPGLLDGTVGFGGEESAGASFLRRDGGTWTTDKDGILLCLLASEIIALTGRTPSEHWAELAGRFGAPAYARIDAPATREQKAVLGKLSPEQVHATELAGEPITATLTTAPGNGAPIGGLKVTTESGWFAARPSGTEDVYKIYAESFQGPEHLARIQQEAQALVTEVLKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHJ2</accession>
    <name>F4FHJ2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733819.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20320"/>
    <dbReference type="EnsemblBacteria" id="AEB45164">
        <property type="protein sequence ID" value="AEB45164"/>
        <property type="gene ID" value="VAB18032_20320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20320"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_2_0_11"/>
    <dbReference type="OMA" id="VTWAGLM"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="14075" checksum="2FC11ADEA0DF8F0D" modified="2011-06-28" version="1">MSVPTRLRLTTVNLDTPDPAALARFYVRLLGWEIKVEEADDVILHNVDGGVGLSFQRERAYVRPTWPAQPGRQQMSMHLEIGVEDLDAALAHALACGATLAEFQPQDDVRVCLDPDGHPFCLWLMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHN7</accession>
    <name>F4FHN7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46406">
        <property type="protein sequence ID" value="AEB46406"/>
        <property type="gene ID" value="VAB18032_26666"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26666"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_11"/>
    <dbReference type="OMA" id="EGHYRKH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="476" mass="50814" checksum="7A3BA495F05AA99C" modified="2011-06-28" version="1">MARLLGQWHALPGRRRSPDYAALAGAVRGLLADGRLPLGVRLPAERDLAEALQISRTTVTAAYRELRDSGHLASRRGAGSWTMLPGTHRVASNGLWIPLDDREMLDLGVAALAAPPELLPAARAAAEDLPRYLGGAGYHPIGIIELREAVAQAYVDRGLPTSPDQIMVTNGTQHALDLVLRLALAPGGSVLVESPSYPNALAALAARRARITTHGLSAELDGWDADLMLGSLRQVRPRVAYLIPDFQNPTGHLMPAELRERLVATAHAVGTDLVIDESFVDLSLDDAVLPPPTASFDRHSRVVSIGGMSKPFWGGLRIGWIRASAPQVQRLAAARVGVDMASPVLDQLVAVHLMAAAPAIVAARRAQLTEQRDALLGALAARLPEWRVSVPRGGVTLWAELDGPISSALARAAEEVGVRLAPGPRFGLDGTLERFLRLPFTLPSADLVEAVGRIAAVRYDLDRGGAPRWREPSVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHX5</accession>
    <name>F4FHX5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S1 and S6 chymotrypsin/Hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_02920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736300.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02920"/>
    <dbReference type="MEROPS" id="S01.513"/>
    <dbReference type="EnsemblBacteria" id="AEB47668">
        <property type="protein sequence ID" value="AEB47668"/>
        <property type="gene ID" value="VAB18032_02920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02920"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043139_0_0_11"/>
    <dbReference type="OMA" id="YRQGFVV"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="392" mass="40996" checksum="69E065A43AD3CCA6" modified="2011-06-28" version="1">MSAVDLVLLLLMLVFAISGYRQGFVIGVLSFSGFFLGALIGLQIGPMFAQQFVDSGTRVLISLAAIFGLAVIGQALAGWLGSHLRRTINNDVARRVDDVGGAFVSLFAVLLVAWLVAVPLGSSSLPWLAASVRSSALLNVVDRVLPDQAQQLSTALRDTVDTNGFPDVFDGLRRTQARQVEPPDPALAGSEVVASGQRSVVKVLGSAPSCSRRIEGSGFVYADDRVMTNAHVVAGTRSVAVELRGERYEGEVVVYDPNRDLAVLYVPGLPGPSMRFAAGNASTGADAIVLGFPLDGPYNAQSARVRDVDRITGPDIYSSGNVTREIITIRALVRSGNSGGPLVSSNGLVLGVIFAAAADDPNTGFAVTAAEARPVALEGAQRTRGVDTGECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI43</accession>
    <name>F4FI43_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30219"/>
    <dbReference type="EnsemblBacteria" id="AEB48007">
        <property type="protein sequence ID" value="AEB48007"/>
        <property type="gene ID" value="VAB18032_30219"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30219"/>
    <dbReference type="eggNOG" id="ENOG5032VE4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067089_1_0_11"/>
    <dbReference type="OMA" id="HHEPLLW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011664">
        <property type="entry name" value="Abi_system_AbiD/AbiF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07751">
        <property type="entry name" value="Abi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="24962" checksum="B9D47104F4A93112" modified="2011-06-28" version="1">MGGDLDQAVALYEWNAKMSGVFWITLGHVEVLIRNAMHRQLTDWSTQAHGEPRWYLDPGQVLAPRRREEIAEARRRATRDGRQETPGRVVAELTFGFWRYLLISSYDRSLWPHLRNAWPSKQLRREVHNPVADLHEFRNRIAHHEPIYNRPLRELHTKALDLASWTCPDTAAWISSRCDVLAVLATRPWTARTPSAPPQRRNARYNPARPAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F124</accession>
    <name>F4F124_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_07790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07790"/>
    <dbReference type="EnsemblBacteria" id="AEB42678">
        <property type="protein sequence ID" value="AEB42678"/>
        <property type="gene ID" value="VAB18032_07790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07790"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_11"/>
    <dbReference type="OMA" id="TVNAWTP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003308994" evidence="2">
        <location>
            <begin position="41"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="93"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="544" mass="57250" checksum="013384D27B96444F" modified="2011-06-28" version="1">MTVEPLDRSVDRRAFLARAAALAVVSTAGATVAVPSVAVASGPSATRRPVKNGALDQPNAYVQPRPEAIADPTELTIAEAAWLIRANKLTPERLVEAYLARISAYDGVYRAFNLVLADAAIAAARAAARGPRRGALHGIPLAIKDNFYTEGVRTTANSFLFQDFVPPYDATALARLKAGGAIVLGKTQMGPLATTRATTPAGVVTTVNAWTPTNRNTDPGGSSTGTATAVAGRMATSGIGTQTGGSITSPSNAQALTGLKPTMGRVSAAGVIPLSYTRDHPGPLARDAKDAAIMLTAMAGEDPADPRSQGLPEVPNLIDAATPVYRRNRVRLRWNTRIGVLPGFANGTSATALARQAYLAQLAEIPGAALVDVPLPEGWSQLTASMFNNIRLPERSEPFMPYLRDNLRGFGVSVTSWLQGALLGGNEFLTGQRAKLLLLERVLDELFDACDVVVQTDPVPFDILGLPEIAFPIGFTSAGVPIGTILGGLPYAEDRLLSVVAAYQATTDWHRRRPTDPPAAARAGTDSAPEELRLTAEQVAELTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F128</accession>
    <name>F4F128_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42682">
        <property type="protein sequence ID" value="AEB42682"/>
        <property type="gene ID" value="VAB18032_07815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07815"/>
    <dbReference type="HOGENOM" id="CLU_3141982_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="49" mass="5161" checksum="1781EFFCED43D976" modified="2011-06-28" version="1">MQPAQLPFGGVVPLGDRVRRGGRVGEREGVVLVGDDPPPGLLAQTDRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1J7</accession>
    <name>F4F1J7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_20630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733880.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20630"/>
    <dbReference type="EnsemblBacteria" id="AEB45226">
        <property type="protein sequence ID" value="AEB45226"/>
        <property type="gene ID" value="VAB18032_20630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20630"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_2_2_11"/>
    <dbReference type="OMA" id="VDRGMHE"/>
    <dbReference type="OrthoDB" id="916788at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="32362" checksum="AC080644F0D1F011" modified="2011-06-28" version="1">MTTTDQRPSAPTSPSGQLLRPPPPTWSQRLRNNRWLSFYTSPLLIALFLLAWKLYVEITDLSRFVLPPPEAVFTSFIEQITDPFVWQTHIWTTFYEVMMGLALAIVLGVGLGLLIGKSPLFDRIARPFIVATQVVPKVALVPLFILWLGFGPSSKVVMAALLAFFPLLINTSFGIRSVPGSMHDLMTTLKASRWERFWRADLPYTMPFILAGMELAVVQATIGAIVGEYLGGDKGLGRYAVNLQNGLQVDKLFGAILIMALFGFTLYSIVTGARRLLIPWHESVQPRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1S8</accession>
    <name>F4F1S8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27151"/>
    <dbReference type="EnsemblBacteria" id="AEB46503">
        <property type="protein sequence ID" value="AEB46503"/>
        <property type="gene ID" value="VAB18032_27151"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27151"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100164_0_0_11"/>
    <dbReference type="OMA" id="TWALAWI"/>
    <dbReference type="OrthoDB" id="1979009at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="27128" checksum="ADF0D7DA2FA3A981" modified="2011-06-28" version="1">MARVILSGLTAAGKTTHTALLAKHLGYDSVHITDLLLAELGGGFGPSTGVWFHRMAEIESLRDGGDADDRVDRILADTMRNRDGVVVDAWALPWYCREPAIRIWIGSDRISRSWKCAVSSPAEVALGPTGCARLVDEKDWLTRQRFLSRYGFDIFADRDVFDFVLDNSHLIDAPTRASADAGINKFHRVLTACVEAGISGDPEPLRALVNDADPALRSCVVRVGGPCGARWRSRDQKNCAPMVPSRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Z3</accession>
    <name>F4F1Z3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_03280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736372.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03280"/>
    <dbReference type="EnsemblBacteria" id="AEB47740">
        <property type="protein sequence ID" value="AEB47740"/>
        <property type="gene ID" value="VAB18032_03280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03280"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="HEVLAFC"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="28278" checksum="87EF500B9AA0A377" modified="2011-06-28" version="1">MNTTTDAPHVRTEGLTVRYGAFQALRDVTVSLPAGGISGLIGPNGAGKTTLLNAISGFTPIAEGSVHIGHRNITALGTRRRALAGVVRGFQTVRLMERESVLTNVLVGTERLPQPNALAQFLALPSQWRARNRDLAAATEVLDLLGLARQAHRRVDELPFASRRLVEVARVLVSAPSVILLDEPAAGLDQEGRQELAAVLTRVHENHPSTMVVVEHDVDLVKSLCSYVIALDSGAFLRDGTPAEVFGDRQVQLAYFGRAASADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F200</accession>
    <name>F4F200_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_03315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03315"/>
    <dbReference type="EnsemblBacteria" id="AEB47747">
        <property type="protein sequence ID" value="AEB47747"/>
        <property type="gene ID" value="VAB18032_03315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03315"/>
    <dbReference type="eggNOG" id="COG5555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496898_0_0_11"/>
    <dbReference type="OMA" id="YDWFGAA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313501" evidence="4">
        <location>
            <begin position="19"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="548" mass="54876" checksum="19E1344BFFDE3852" modified="2011-06-28" version="1">MSVSVVAASLMVSPPAQAAAEEVRTITREDVILQYQRVPKAVTPVKGTGPTRSDFDGDGVDDVAAASDLSQSGLPHQATGVVVVRYSSAPHVDYFAGVLSSDGGCGCFGMALAAGDFNGDGYDDLAIGDSDEVDPGNKTHAGGVWVIPGSRTGLVVNSAQHFNQSSPGVPGAAEDYDWFGAALAAGDINGDGRDDLAIGAYGESIGKVREAGAVTVLYGGVGGLRTAGAQQLHQNLAAVPGAAERGDHFGFTLAIGKVNENRYADLVIGAPHENDGQTWNGSGMVTLMWGAKTGVKLSGATSVTGAGVYKATGRQDTIAWYLGEALAIGDVNGDGLGEVIAGAPGAQTPHLNGGLIAAFTGRTGGAGLSGTAVKIITQRTAGVPGSPEQEDRFGAALAVGDVTGDGRADVLVGAPGESIGTKTKAGTIALLRGSASGLTGTGAQGFDQDHAVVPGGAERGDHFGASVAILNLDGKGPLDAIVASTGEEVAGDQAGYPSGTLSRFHGASGGLVPQAGSWSGASLRTDRIWPLRYGARIAGPVSGGPRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F218</accession>
    <name>F4F218_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736397.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03405"/>
    <dbReference type="EnsemblBacteria" id="AEB47765">
        <property type="protein sequence ID" value="AEB47765"/>
        <property type="gene ID" value="VAB18032_03405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03405"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073035_0_0_11"/>
    <dbReference type="OMA" id="TNWLSPW"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="63"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="30793" checksum="75A22ADFA62EA6C9" modified="2011-06-28" version="1">MTTADDRARRAARRRFATLRRSVTLFRAFLVEQTDPDHFYGLLAADSVTQLHGYTELTGRTVLDVGGGPGYFAAAFRAAGSHYVGLDPDVGDFSAAGESVAGMLRGSGTALPVRTGSVDIAFSSNVVEHVAEPPRMLDEMVRVTRPGGLIFVSYTPWFSPWGGHETAPWHYLGGDRARRRYERRTGRPPKNRFRETLFPVSIADTLRWARSNDQIDMVDALPRYHPWWARWVIRVPWLREVVAWNFVLVLRRRAEHQPDTVQKSELTGGRVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F289</accession>
    <name>F4F289_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731449.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08300"/>
    <dbReference type="EnsemblBacteria" id="AEB42778">
        <property type="protein sequence ID" value="AEB42778"/>
        <property type="gene ID" value="VAB18032_08300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08300"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079903_0_0_11"/>
    <dbReference type="OMA" id="FENSTAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="29936" checksum="E9E2F1E222320232" modified="2011-06-28" version="1">MAWSTRQLADLAGVTLRSIRHWHDIGLLPEPERLTNGYKQYGARHLILALRISRLSGLGFALDDVARMLKSEEYGQESLHGLRAELDTTIGRLERIRAEIDELIRLGVSPDLSPEALVAMETLGRDPASRDVAIILSHLIPREDMAALVAVLEGVPEELRRINTAILELPAEASEDEIVTLAGRAATALKTFIAANYETFPDIGSGRANADVVGAVAAENMNQAQRRVMRLIHDQLPSETGGSTPGETMQRQGDEQWLRSRRDAREGDHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2P8</accession>
    <name>F4F2P8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sec-c motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45313">
        <property type="protein sequence ID" value="AEB45313"/>
        <property type="gene ID" value="VAB18032_21065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21065"/>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099590_2_2_11"/>
    <dbReference type="OMA" id="WLYVDGD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="107" mass="11998" checksum="9C5E6937FD9ECE83" modified="2011-06-28" version="1">MHSGEAQAPTAEALMRSRYAAFAVGDPDYLLHSWHSSTRPARLRLDPGQRWTGLEVVATEQGGLFDSTGTVQFRAHYRDGTGAGSMTERSRFVREDGRWVYLDVDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F342</accession>
    <name>F4F342_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736453.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03695"/>
    <dbReference type="EnsemblBacteria" id="AEB47821">
        <property type="protein sequence ID" value="AEB47821"/>
        <property type="gene ID" value="VAB18032_03695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03695"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068637_2_0_11"/>
    <dbReference type="OMA" id="ADPTYLH"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="28035" checksum="09D8723CC5202B47" modified="2011-06-28" version="1">MGASDDDRLELVVDPVRPTGRTLLAGGVEQSYVDLADPTYLHFEYVRRMAAVADLAAPAGRPLDVLHLGGGALTLPRYLAATRPGSTQLVVEREPAVVDLVTRELPPVPAGVEIHVADAREAVAEVPAGAYDLVLADIYRAARMPPHVATVAFAAEVARVLRPDGIYLVNVTDLPPLVLARVQAATLRAVFADVCVVADRRMLRGRRYGNVVLAAALRPDRLPVARLVVRALRDPLPGGVLHGPALDTFIAGARPRTDDVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3H0</accession>
    <name>F4F3H0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14830"/>
    <dbReference type="EnsemblBacteria" id="AEB44078">
        <property type="protein sequence ID" value="AEB44078"/>
        <property type="gene ID" value="VAB18032_14830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14830"/>
    <dbReference type="eggNOG" id="ENOG5033311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334319_0_0_11"/>
    <dbReference type="OMA" id="TSPXTSP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="854" mass="86143" checksum="3DB4AF48BD8170E4" modified="2011-06-28" version="1">MPGGPAAAGGPRPAGGPPFFGGPVTGPIPGTPDGPVSGVPVGPVSGPPTSRRTVGRPAGTPAGPRRAAPDHLDPAGVPGPAEGNTGPRPYAQPGRRAVPEAPSGGEPIERGPGRPPAGMTPVSGAGPTGAPAGGRRAGRRRAAEPDVDQPAVPLSGNAPSIPESSSAGDEHPPRARRAASVPPQTPATPSRGRRAAPEPPVTGARAAGATDVPASVHPGEPEPLGRPGRRAAEEGPVTRSGPADDLGRRAADPVGRTDHALHQADPTSGTGRAPRPADPASRADRPQSPADAAGGAGRPQRPADWLRQAGRAHHTDPALRTIRPGNAPAGSSTDDLPATREQRGMDTPTGPPPGRPAPGVETGRPGTGPRRPAAGAPRHDEPPTGRGRAVPPGVPPVSNQPGMPPAGSQPSPGGPPTTGQSLPGWPGTASTAGRAGSASVAGRAGSAPAAGPVRVPGQPDTAVPGAARRAVEPDDLPPNVARPGRLPEPPRTGRSGEFPSVSPPGARRGDEPPVPPRAAPTSGGPRVAGGPDGGPAGGPGRPGGPPPGPHRGNVRPEERQAGRAAPPPRNPSRPEPSGTAPVPPSPSRVGESPVVARAAAAVAPMGPAVLRPGMEPEVRRPADAERGDADGPVDDGPDDGGELRHQGGGNQRLRVVVLAVASVLLLGVVPAFFGLRAEGRDPVFASLDDLAVPTWAAVDPVDAVSGSRWCLLDCRLRERTVNSERSPEETAQVYESALSQDGWQPWKPAYCPEQEEKGSYTCWRRDELTLDLWVRAPTCVPPPVDGEPAVVPSLDPETAAEECPGSLVTVKVRNAIDDDRTRPQPSTDPSLTGVDPYPTLGDDPLGDLTPSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3M1</accession>
    <name>F4F3M1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">VAB18032_15085</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732794.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15085"/>
    <dbReference type="EnsemblBacteria" id="AEB44129">
        <property type="protein sequence ID" value="AEB44129"/>
        <property type="gene ID" value="VAB18032_15085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15085"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_11"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB44129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="24248" checksum="5009B8D9B0C3E80E" modified="2011-06-28" version="1">MTVPPLIVAPSILAADFARLAEEVRAVENAADWLHVDVMDNHFVPNLTIGLPVVQSLRAATELPFDVHLMIEDPQRWAPGYADAGAYNVTFHAEACDDPVALAKDLRAAGAKAGLAIDRDTPIEPYLDLLPNFDTLLVMTIKAGFGGQRFIPQLLDKVRAVRRHRDAGHLELRIEVDGGIAADTIEQAAAAGADAFVAGTAVYGADDPAEAVRRLRQLAERAADGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3V7</accession>
    <name>F4F3V7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734061.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21540"/>
    <dbReference type="EnsemblBacteria" id="AEB45408">
        <property type="protein sequence ID" value="AEB45408"/>
        <property type="gene ID" value="VAB18032_21540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21540"/>
    <dbReference type="HOGENOM" id="CLU_2468177_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="88" mass="9966" checksum="3E26CB2F3CC19BAE" modified="2011-06-28" version="1">MSSERNPQPRDEKVPAVDANQTMARRFVQQRLAELPHRPEEAEARLRGLLAIYEELNARGHPEPMVLLAGVLGIPVDVLIRHLRAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F402</accession>
    <name>F4F402_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27876"/>
    <dbReference type="EnsemblBacteria" id="AEB46648">
        <property type="protein sequence ID" value="AEB46648"/>
        <property type="gene ID" value="VAB18032_27876"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27876"/>
    <dbReference type="eggNOG" id="COG5637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142198_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="137" mass="15097" checksum="36104A374C0D7681" modified="2011-06-28" version="1">MGQLRTALAVTGVLGAALLRTVRTAVVRRLRRRSRSVRRWPEPWQVVAIARPPGEVLPEGVWPEPLRRLDGAIQVELRSPPDGRRTELAARPVTQPAPTGLAAHLIGDEPQLAVRHALWQAKQLAESGELPPTGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F440</accession>
    <name>F4F440_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735336.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28066"/>
    <dbReference type="EnsemblBacteria" id="AEB46686">
        <property type="protein sequence ID" value="AEB46686"/>
        <property type="gene ID" value="VAB18032_28066"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28066"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_11"/>
    <dbReference type="OMA" id="LRALMCY"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="38190" checksum="6649075E62A4DFE2" modified="2011-06-28" version="1">MTATITPTDANELRARFDAELTAFLDRQDPDWPDGAPRGVFTTLHRFVLAGGKRLRPLFCYWGWRAAGGPDSTPIVTAAAALELFHAFALIHDDILDGSDRRRGEPSVHRIFADLHTRSSWRGDPEAYGRNTALLCGDLCAAWSDQMFHECGLDAESVHRGYAVFSLMRTEVIAGEYLDLVSGVGGGSVASALTVIRMKAARYTVTRPLQIGATLAGASSELVDALAEFGDPLGDAFQLRDDVLGVFGDPAVTGKSILDDLREGKPTVMMALARDAANRAQSARLRELFGNPDLDAEGAAELREIIESTGARTTIEQMIQVRADAALAALAQTTVTPESRAALTALAAQAVDRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F445</accession>
    <name>F4F445_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735341.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28101"/>
    <dbReference type="EnsemblBacteria" id="AEB46691">
        <property type="protein sequence ID" value="AEB46691"/>
        <property type="gene ID" value="VAB18032_28101"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28101"/>
    <dbReference type="eggNOG" id="COG1260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021486_0_0_11"/>
    <dbReference type="OMA" id="WDHIAFD"/>
    <dbReference type="OrthoDB" id="669352at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="PTHR11510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="214"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="386" mass="40135" checksum="19E01D09FEF2922F" modified="2011-06-28" version="1">MRTGVWLVGARGSVATTSIVGALALRAGLTRPTGCVTELPAVGGPALPTFSDLVFGGHDVVATPLAKRAETLAAAGVLPARLVAALPEELAAVDQELRPAPTDGSQADRAAAIVRDLTGFRDRHGLARVVVVNVSATEAAPEPHPAHADPAALSAALTGPDEVLPPSSLYAYAAVTAGCPYVDFTPSTGLRLPALSALAEQHRVPYAGHDGKTGETLLKSVLAPMFAMRNLHVRSWSGTNLLGGGDGATLADPAANAAKVRSKQRVLGETLGYLPQGDTRIDYVEELGDFKTAWDLITFAGFLGTGMRLEFTWHGCDSALAAPLVLDLARLAAAAHAAGRSGPLTELAFFFKDPLGEGTHSLADQWTRLCEFAHRLHTGGTDDPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F479</accession>
    <name>F4F479_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding region ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736524.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04050"/>
    <dbReference type="EnsemblBacteria" id="AEB47892">
        <property type="protein sequence ID" value="AEB47892"/>
        <property type="gene ID" value="VAB18032_04050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04050"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660458_0_0_11"/>
    <dbReference type="OMA" id="KYTQDEG"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="202"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="416" mass="44903" checksum="FA211EA93B0FDFCA" modified="2011-06-28" version="1">MPDRTDYSALIAGHTVIIEMINSGDAGLPVLNRLLRMAQPALGAAGMAFVEFAPSGGRVIAATGAAEWIVGRPVPANDPATTCLLSGPRVRCVRTDQLTNQLAVELAGRGLLQMVVSRAELGGHTVGSLHALYSADAEEPSTEERGVVAYLGTCIAHMYGDHSHLPVQGDDPTVATRADGPDLRDALDQQRHDRERDLFVAVTSHELRTPVTVIKGYADTLNDHWDSLGEADRRQAARVIGQRANELARLLDRLLSSAAEVWPGDGPPAPFDFAETLRVAVANLPADLRRRATLQVPADLPRAVGHRQSLATVLTELVTNAGKYSPPGSPIEISAAADGRTVSLQVSDRGIGIRPEHVERAFERFWQGDSGDRRRYPGTGLGLYLVRRIVEQQNGWVFLRPRTGGGTVAEMRLPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4J0</accession>
    <name>F4F4J0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="12" type="ordered locus">VAB18032_09150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731619.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09150"/>
    <dbReference type="EnsemblBacteria" id="AEB42948">
        <property type="protein sequence ID" value="AEB42948"/>
        <property type="gene ID" value="VAB18032_09150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09150"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_2_2_11"/>
    <dbReference type="OMA" id="WAPPCRE"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="690"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="869"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB42948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1232" mass="134409" checksum="BC8A674158B72C28" modified="2011-06-28" version="1">MTALTGLFAAALADPGLARVRDLARSGAAQVDGLDLTAPPALRPFAVAAVAADPTTRTDKQGGDKQGGGKQGGGAGRPVLAVTATSREAEDLVAALGSLLPAEQVAIFPSWETLPHERLSPRSDTVGRRLAVLRRLAHPDATDAHGRTGPLRVVVAPVRSLLQPQLKGLGDLEPVRLSAGDEADLEQVARRLTDMAYARVDLVTKRGEFAVRGGILDVFPPTDEHPSRVEFWGDEVEEIRTFAVADQRTIEQVPQLWAPPCRELLLTPAVRERAAALAQQHPELAEILDKLAGGVPVEGMESLAPALIGADSMELLLDCMPAGTHVLLCDPERIRTRAHDLVRTSDEFLAASWAAAAVGGQAPIDLGAAAFRTLADVRAHAATLRQPWWTLSPFGLAEPGVAAARQPWEDEPDTVDITPDDAIAVTLAAQPAPLYHGETARVVDDLKRWAGEGLSIALVFEGHGPAQRAVEVLRDGGLGARLTEQVPAAPAAGELLVTCGSLTGGFVDEAARFVLLTGNDVTGGRGASTRDMRKMPSRRRNTIDPLELRAGDHVVHEQHGIGRYVELVQRTVNGASREYLVIEYAPSKRGQPGDRLFVPTDQLDQLSRYVGGEQPTLHKMGGSDWQKSKARARKAVKEIAAQLIQLYAARKASKGHNFGPDTPWQRELEDAFPWQETPDQLAAIDEVKRDMEQSVPMDRLICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLVQQHYNTFAERMSQFPVTIRQLSRFQTPKEAEQTLEMVANGSADIVIGTHRLLAASTRFKSLGLVIVDEEQRFGVEHKEHLKSMRAAVDVLSMSATPIPRTLEMAITGIREMSTIATPPEERHPVLTAVGAYDDRQVAAAIHRELLRDGQVFYLHNRVESIERTARKLRELVPEARVAVAHGQMGEEALEKVMVGFWEKEFDVLVCTTIVESGIDIPNANTLIVERADLLGLAQLHQIRGRVGRGRERAYAYFLYPPDKPLTEHAHERLATIAQHTELGAGMYVAMKDLEIRGAGNLLGGEQSGHIEGVGFDLYVRMVGEAVSAFKGEQPEEETDVKIDLPVDAHLPHDYVGVERLRLEMYRKLAEARDEERLREVAVEMTDRYGEPPAPVQNLIAVARFRLLARRYGLTDVSVQGKHLRFSPLPLPDSKQMRLKRYHPDSVYKTALDQVSVPRPTTRRIGGEPLRDQALLDWCAQLLSDVLGAPTAAQPATAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4W4</accession>
    <name>F4F4W4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734106.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21765"/>
    <dbReference type="EnsemblBacteria" id="AEB45453">
        <property type="protein sequence ID" value="AEB45453"/>
        <property type="gene ID" value="VAB18032_21765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21765"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097062_2_1_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="138" mass="15278" checksum="40FE4D2F8C3D896F" modified="2011-06-28" version="1">MALRLHDQTRGARPARRKVAARPGGHLGHAERHRFQEVFRGAAEPLPWPDEHTPLVTTRSPSQVFGFYRDQCEISDAIIAAAPLTATPAGRHPDEPLASQTTDLRRIVLHVIEETARHAGHLDVVRELIDGRTGLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F530</accession>
    <name>F4F530_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28206"/>
    <dbReference type="EnsemblBacteria" id="AEB46712">
        <property type="protein sequence ID" value="AEB46712"/>
        <property type="gene ID" value="VAB18032_28206"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28206"/>
    <dbReference type="eggNOG" id="ENOG502ZT8H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1675865_0_0_11"/>
    <dbReference type="OMA" id="AYDQLCE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="162" mass="16820" checksum="75D498D352F9733E" modified="2011-06-28" version="1">MVESGVPTPPAGPGVAPPFAAPPTEGRRSRLWLGLGAGALALVLCCGGGGAAVVGLLVSGVQAIEEQGRTVSSDYYRALADGEYGQAYDQLCEDAKRRESRQEFERRAAAEPQIVSYRVGSVDTTTLTVPVDVTLAGGGQERQQVVLGQDQQTGAMEVCGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4F562</accession>
    <name>F4F562_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="11" type="ordered locus">VAB18032_28366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735394.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28366"/>
    <dbReference type="EnsemblBacteria" id="AEB46744">
        <property type="protein sequence ID" value="AEB46744"/>
        <property type="gene ID" value="VAB18032_28366"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28366"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_11"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="148"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="381" mass="40297" checksum="D77B8A7E67F8F9D4" modified="2011-06-28" version="1">MARDYYGILGVSRGASDDEIKRAYRKLARQFHPDVNPDPEAQEKFKDINAAYEVLSDDRKRQIVDLGGDPLAPGGGGAGGPGGPGGAGPFVGFQDIMDAFFGGATGAGRGPRPRTRPGADAILRLELDLQETAFGVEAPITVDTAVLCTTCSGAGTAAGTHLATCEACGGRGEVQSVQRTFLGQVVSARPCTVCQGYGTTIPSPCPTCAGDGRVRTRRSLTVKIPAGVEDGMRIRLAQQGEVGPGGGTAGDLYVEIHERPHDVFSRKGDDLHCRVTVPMTAAALGTRLTIKTLDSEEPVDVKAGTQPGSTLRLRARGVPHLRGTGRGDLYVHLDVRTPTKLDADQERMLRDFAKTRGEEVAELTKQGGFFSRMRDAFNGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5B3</accession>
    <name>F4F5B3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_04395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736592.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04395"/>
    <dbReference type="EnsemblBacteria" id="AEB47961">
        <property type="protein sequence ID" value="AEB47961"/>
        <property type="gene ID" value="VAB18032_04395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04395"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_11"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="316" mass="33761" checksum="5CA92D16B911176B" modified="2011-06-28" version="1">MDEVRNLIIIGSGPAGYTAAVYAARANLKPLIIEGVQSGGALMTTTEVENFPGFADGILGPELMDNMRKQAERFGAEFLTDDVTRVELTDTASPGAYSTVWVGESAYRARAVILATGSAWRPLGVPGEQEYLGHGVSSCATCDGFFFRNHHIVVVGGGDSAMEEASFLTRFAESVTIIHRRDSFRASKIMAERALSNDKIKVEWNSVVEEILGADGKVSGARIRNVHTGETKVLDVTGVFVAIGHDPRSELFRGQVELDDEGYVKVEAPSTRTSIPGVFAAGDLVDHTYRQAITAAGTGCAAALDAERFIATLATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5F7</accession>
    <name>F4F5F7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="10" type="ordered locus">VAB18032_09355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731660.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09355"/>
    <dbReference type="EnsemblBacteria" id="AEB42989">
        <property type="protein sequence ID" value="AEB42989"/>
        <property type="gene ID" value="VAB18032_09355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09355"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_0_0_11"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="9">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="8">
        <location>
            <begin position="84"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="17644" checksum="578E8B80F73B1234" modified="2011-06-28" version="1">MSNGNEAPATWLSQDAYDRLKAELDELIANRPIIAAEINARREEGDLRENGGYHAAREEQGKAEGRILYLKELLRTAQVGEAPTADAVAPGMVVTIYFDDDADDTETFLLGSREIASTTDLTVYSPESALGKAILGGKAGQTCTYTAPSGADIKVTVVSFEPFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Q5</accession>
    <name>F4F5Q5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15790"/>
    <dbReference type="EnsemblBacteria" id="AEB44268">
        <property type="protein sequence ID" value="AEB44268"/>
        <property type="gene ID" value="VAB18032_15790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15790"/>
    <dbReference type="HOGENOM" id="CLU_2848627_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="7332" checksum="A0A5D10CFBDD4761" modified="2011-06-28" version="1">MWPADPPLLTFVWRRLFAHDLHRLYPSVTGSAADMFDRFLGWPARPTHAYRVSTTTAVSVEGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F646</accession>
    <name>F4F646_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28636"/>
    <dbReference type="EnsemblBacteria" id="AEB46798">
        <property type="protein sequence ID" value="AEB46798"/>
        <property type="gene ID" value="VAB18032_28636"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28636"/>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082566_0_1_11"/>
    <dbReference type="OMA" id="CWKLNDR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="24302" checksum="FD180E49BB6F01EF" modified="2011-06-28" version="1">MLSVNVGRPRPNPAKGGLTGIDKRPIDGPVAVAAPGPKGTGEVGLAGDRVYDVKHHGGTDQAVYAYAREDLDRWAAELDVPLDNGGFGENLTTAGLDVNAALIGERWRIGPDVVLEVSSPRIPCSTFQHWLQQQGWIKRFTQAAVPGAYLRVIEPGELRGGDPIEIVHRPEHQVTVELAFRALTLEPDLLPQLLAADALPEEARDTVRRRTPRAPVAGSADPSTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6F2</accession>
    <name>F4F6F2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activator of hsp90 atpase 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731769.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09900"/>
    <dbReference type="EnsemblBacteria" id="AEB43098">
        <property type="protein sequence ID" value="AEB43098"/>
        <property type="gene ID" value="VAB18032_09900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09900"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082120_0_0_11"/>
    <dbReference type="OMA" id="RVEMFIN"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="279" mass="31498" checksum="B66216B56A84849D" modified="2011-06-28" version="1">MTEPMNIAIRLAAPIARVRQALTDPAELRIWLAEHVEVDLPKRYEFWGRYTPEGDAPHQRLLDVDDDRLRFAWLLDGEETTTEITLRPDGPDATVLHLSQTHFDFNDVINGTSIRGVLQTYWALATANLNAYLEGSPLLPKTDFTSTDFRVEMFINAPADKVWESLTDSEQATAWFGYPIGIEPWLGGRYAMGGLDQGDAAKIVDLEPGRRMSVDWKAPGVTTWELAESEGKTRLTFVQSGFDEQNPPYAAWAGLVSGLAELRRYHEIPNWQPIWIPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6G4</accession>
    <name>F4F6G4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_09960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731781.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09960"/>
    <dbReference type="EnsemblBacteria" id="AEB43110">
        <property type="protein sequence ID" value="AEB43110"/>
        <property type="gene ID" value="VAB18032_09960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09960"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_47_0_11"/>
    <dbReference type="OMA" id="YFFMLNI"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="25"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="407" mass="41762" checksum="30268C6EA7522C06" modified="2011-06-28" version="1">MPQTATPSTAPDRVAVPTGRAAIGLLVLLGSLTAIGPLSLDTYLPALPDMTRDLSASQARIQLSLTTCLIGVAVGQLVTGPLSDRWGRRRPVIVGLAAYTLLSLLCTLAPSAETFAAARFFQGFAGGMGTVVARAIVRDLYAGRAAAKYFSRLTLIFGLAPMIAPAFGSLLLNFGDWRVIFVALTVIGALLATVVAWRLPETLPVARRNTGGLLSIARIARVLITDRIYLGYTLTQGLAFAGLLGYLSGSSFVLQDVFGLSVGMYSLIFGVNSLAFVAVGQLNARLLDRHGPRQLLITALGLGLLAALGLIAGALLQALPLVIVAMLVFLGSLGMVMPNGTALALDRHGAHAGTAAALLGGIQAVVAAGAAPLVGIGGEGSALPMALVIAGAAAGSLLVVLTLARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6H9</accession>
    <name>F4F6H9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732971.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15985"/>
    <dbReference type="EnsemblBacteria" id="AEB44307">
        <property type="protein sequence ID" value="AEB44307"/>
        <property type="gene ID" value="VAB18032_15985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15985"/>
    <dbReference type="HOGENOM" id="CLU_2037087_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="13615" checksum="30EBF515C4715995" modified="2011-06-28" version="1">MTDPIREQIRILRWETPAAVQQRQALADEARSALITALERRLVCRPGVKDALAVWDLDPLPQRWTVSADAQLSYTRSHTDDAQAHAQARFGVPDEIRQLDPAVAVYPQRVIEVTPLPEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6R4</accession>
    <name>F4F6R4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma-factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22445"/>
    <dbReference type="EnsemblBacteria" id="AEB45589">
        <property type="protein sequence ID" value="AEB45589"/>
        <property type="gene ID" value="VAB18032_22445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22445"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152584_0_0_11"/>
    <dbReference type="OMA" id="HIDAAGI"/>
    <dbReference type="OrthoDB" id="2072074at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="44"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="14872" checksum="CFAEA6CC01A0483C" modified="2011-06-28" version="1">MTTPRRPECTVPLVEVAITEFDLACLPETGTVFDRLLTLHPGQVVVDLSDCRHIDAAGIGLLLDVHRRMLRIGGVLSVRNPNPRIARILQTARLDQILPVHVDGAAPSAVTTAPGAVSSDAAVSAAGHPTVYGRAAVTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6T1</accession>
    <name>F4F6T1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="5" type="ordered locus">VAB18032_22530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22530"/>
    <dbReference type="EnsemblBacteria" id="AEB45606">
        <property type="protein sequence ID" value="AEB45606"/>
        <property type="gene ID" value="VAB18032_22530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22530"/>
    <dbReference type="eggNOG" id="COG0829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055097_2_0_11"/>
    <dbReference type="OMA" id="MARFCAQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="265" mass="27239" checksum="CD1A389DEED0ED6A" modified="2011-06-28" version="1">MRATAWLVARADRHGRTTLAELRGESPLLLRQVPGPGGGVTVYVVGGAAGPLAGDDLRLDVEVGPGAVVRVQTVAASIALPGRPGAVSRMLLRATVAAEAVLHWLPEQLVAAAGCAHIADAQVEVAEGGTLHWRDELICGRHREQPGHAEINTWVDLAGRPLLRQSLTVGPQAPGWAGPAVLGGAPATGSLLVLDPTRPPESPVVRGTLARLPLAGGPATLWTATAPDAHTLRSYLEPDNPANSLTATAGRDSAGGGEREVVRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6W5</accession>
    <name>F4F6W5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Had-superfamily hydrolase, subfamily ia, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22700"/>
    <dbReference type="EnsemblBacteria" id="AEB45640">
        <property type="protein sequence ID" value="AEB45640"/>
        <property type="gene ID" value="VAB18032_22700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22700"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_0_11"/>
    <dbReference type="OMA" id="WDLRPVF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="26520" checksum="52037B57B9EA7871" modified="2011-06-28" version="1">MQHVPDHAEPTDSVRDVQPTPSRRPVEAVLLDFHGTLAQVEEPREWVLAAAATCGVDLDRVRATSLADRLLTAGRAGGPLPARVPPQLAELWADRDLYEHAHRGAYTGLAATVDAGIDGFADALYERVLTPEGWVPYPDTAPTLAALRAAGVRVAVVSNIGFDIRPHFAAWGLADLVDAFVLSYEVGRCKPDPAIFWRACGMLGVDPEHALMVGDTPADAGAVAAGCAALVLPAADVGRPNGLGSILSLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F764</accession>
    <name>F4F764_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xylB</name>
        <name evidence="8" type="ordered locus">VAB18032_29286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735576.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29286"/>
    <dbReference type="EnsemblBacteria" id="AEB46928">
        <property type="protein sequence ID" value="AEB46928"/>
        <property type="gene ID" value="VAB18032_29286"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29286"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_12_0_11"/>
    <dbReference type="OMA" id="WHVMGVT"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="249"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="475" mass="48374" checksum="4A2DDA175CC3B6F6" modified="2011-06-28" version="1">MPLVAGVDSSTQSCKVVVRDAETGTLVREGRAPHPDGTEVDPEAWWSALQTAIEAAGGLADVAAVSVAGQQHGMVCLDDAGQVIRPALLWNDTRSADAAAELVAEAGGGRFWADAVGSVPVASFTVTKLRWLARHEPANAERVAAVCLPHDWLTWRLAGAPGLEALRTDRSDASGTGYWSPATGEYRPDLLERALGREVRVPTVLGPAESAGHLDPAAVSGAAPALLAPGAGDNAAAGFGVGAGSGDVLVSIGTSGTVFSIAETPAADASGTVAGFADVTGRFLPLVATLNAARVLDAAAGMLRVGLDELADLALSAPPGADGLVLVPYLEGERTPNRPLATGAVHGLTLRTSTPAHLARAAVEGMLCALADGLDALAAQGAQPRRVLLVGGGARSAAVRRIAAQVFGCPVVVPPPGEYVADGAARQAAWLALGTTEAPSWTPAGTREYAAEPVPAIRERYAQARDHHLDRLAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4F767</accession>
    <name>F4F767_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10035"/>
    <dbReference type="EnsemblBacteria" id="AEB43125">
        <property type="protein sequence ID" value="AEB43125"/>
        <property type="gene ID" value="VAB18032_10035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10035"/>
    <dbReference type="HOGENOM" id="CLU_3359100_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="36" mass="4115" checksum="EA64CDC8B605CA00" modified="2011-06-28" version="1">MDFSGQHQDVFRILQVAAHSTRDSTQPMLLISLRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F769</accession>
    <name>F4F769_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731798.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10045"/>
    <dbReference type="EnsemblBacteria" id="AEB43127">
        <property type="protein sequence ID" value="AEB43127"/>
        <property type="gene ID" value="VAB18032_10045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10045"/>
    <dbReference type="eggNOG" id="ENOG5031ZGQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1266452_0_0_11"/>
    <dbReference type="OMA" id="PAPARWM"/>
    <dbReference type="OrthoDB" id="2128665at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="23551" checksum="A7171B5C842854AA" modified="2011-06-28" version="1">MRPEHPQHVPDRAGPSGVEGGWQVVRWRRALAVPAPLIAMVLGAAMATQWEVGGGRAIWSLPAPARWMAENLPLFAGSEPAWIWRGPFFVSVLLTLPLVWTVTRHATAAPRCLTRYGLLAATIAIGLEYNSPGYGWVFDLVALLTALVGTVWCGVQGLRRGAQPRRVAWALVAALPLTPPAGFLTFWYLPPGLTMGILLAWAAAAIAAGRNERDTPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F776</accession>
    <name>F4F776_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10080"/>
    <dbReference type="EnsemblBacteria" id="AEB43134">
        <property type="protein sequence ID" value="AEB43134"/>
        <property type="gene ID" value="VAB18032_10080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10080"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637626_0_0_11"/>
    <dbReference type="OMA" id="CAGRNTA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="284"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="407" mass="42385" checksum="A23D59148F740496" modified="2011-06-28" version="1">MLVLAVVAALGVTAACSEPELDCSRPTDRPVGGVRNVAVLLDVTGSTRSTGVAPDYVAAVESLLKDAVDDGEVVSVGTFDGSASTVEWTVDSFPTATTANQPSNQRKQQATATACLSRFVRQAATAPARTSGTDLLGALGVAAAHTATGGQARRTVVLATDGLSTTGCADLSRTPAGRMTFIDTAATECPQRRDWPAALANTHLTMIGVGRPANGQPILETGHLAWLRQYWERLCLVAGAASCNISTAPVPTRSAGSAAPAGAEAPDDPVVHFKPGAGPPAEPVQTVTFNIPSAALFATDSDEIGPAGRNRLAEIAEENKLPKATHLEVVGHTDSRDDADYNQDLSERRAAAVGRILRELGVPVSKTRGRGEEVRLCLAERLPGGGWDDACLQRNRRVEIVISKQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7C3</accession>
    <name>F4F7C3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731852.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10315"/>
    <dbReference type="EnsemblBacteria" id="AEB43181">
        <property type="protein sequence ID" value="AEB43181"/>
        <property type="gene ID" value="VAB18032_10315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10315"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_11"/>
    <dbReference type="OMA" id="FMTMKAA"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="200"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="29201" checksum="D7B1C3F420A10C30" modified="2011-06-28" version="1">MEHAHQPTALLPGDVRIPLLGFGTWQATGETAFKAVLAALDAGYRHIDTATMYGNEEEVGRAVRESGLRREDVFLTTKLPPERVGQERRTIEESLRALGVDHVDLWLVHWPPSEPGALIPVWREMLAARDEGLARAVGVSNFSTGQIDELIQATEENPAVNQIKWSPFLYDRQRHIEHRDRGVVLEGYSPFKTSDLSDPVLVRIAAAHDVSPAQVVLRWHLDHEIVAIPKSVTPERIRANADVFGFSLTAEEMRDIDALGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7L3</accession>
    <name>F4F7L3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733109.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44452">
        <property type="protein sequence ID" value="AEB44452"/>
        <property type="gene ID" value="VAB18032_16740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16740"/>
    <dbReference type="HOGENOM" id="CLU_2398775_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="93" mass="11005" checksum="44C3C3CA290013B4" modified="2011-06-28" version="1">MIEEARRELERMRRSSVVWRELRYERATGADGYDCDGRAARRAAVLWALQYDRRAEDLPLVRWLAEQEAWCRREAPFQGLTEETELCSRSIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Q7</accession>
    <name>F4F7Q7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ordered locus">VAB18032_22970</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734346.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22970"/>
    <dbReference type="EnsemblBacteria" id="AEB45694">
        <property type="protein sequence ID" value="AEB45694"/>
        <property type="gene ID" value="VAB18032_22970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22970"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_0_11"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB45694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="30360" checksum="A9CDB5D80A03610D" modified="2011-06-28" version="1">MTWIEAIVLGIVQGLTEFLPVSSSGHLRITSAIFFDQDAGASFTAVTQLGTEAAVLLYFAKDIWRIGRTWTVGIWDSSVRSSLDYRMGWYVIVGSIPIGLFGFLFKDQIRETARNLWVVATTLIVFAFILAFAEYWGRQTRTLKDFRMRDGVVMGFAQALALIPGVSRSGATLTFGLFLNLTRETAARYSFLLAIPAVVMSGIFSLGDVFEPAAPGTSVPSVAQMVVATLIAFAVGYAAIAWLLRYVAHHTLYVFVLYRVAVGTLVLALLMTGTISAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F817</accession>
    <name>F4F817_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="15" type="ordered locus">VAB18032_29606</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735640.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29606"/>
    <dbReference type="EnsemblBacteria" id="AEB46992">
        <property type="protein sequence ID" value="AEB46992"/>
        <property type="gene ID" value="VAB18032_29606"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29606"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_5_2_11"/>
    <dbReference type="OMA" id="NIATVGY"/>
    <dbReference type="OrthoDB" id="2078221at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB46992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="73" mass="7441" checksum="35088896785E132E" modified="2011-06-28" version="1">MDVIAAIEGSVNTIGYGLAAIGPGIGVALVFAAYIQASARQPESAGYNRTWLVLGFALVEALALFGLVLAFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F839</accession>
    <name>F4F839_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase/Xis, DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730705.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04525"/>
    <dbReference type="EnsemblBacteria" id="AEB42031">
        <property type="protein sequence ID" value="AEB42031"/>
        <property type="gene ID" value="VAB18032_04525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04525"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_9_1_11"/>
    <dbReference type="OMA" id="TLYQWRY"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="7061" checksum="F871CA47ED232337" modified="2011-06-28" version="1">MTAPTMERLWTVQEVSAFLGVPVGTLYQWRYRRTGPRACRVGRHLRYRPADVRAWLDGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F863</accession>
    <name>F4F863_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_10530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731895.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10530"/>
    <dbReference type="EnsemblBacteria" id="AEB43224">
        <property type="protein sequence ID" value="AEB43224"/>
        <property type="gene ID" value="VAB18032_10530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10530"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101331_0_0_11"/>
    <dbReference type="OMA" id="LLIWPRT"/>
    <dbReference type="OrthoDB" id="1721242at2"/>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="11">
        <location>
            <begin position="11"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="162" mass="16778" checksum="B4C4D893A0A8D558" modified="2011-06-28" version="1">MNRKLLPWLGLVVRLGLAAVWLYAGATKVGDLAASGRAVHAYQVLPYDVSVVVGAVLPFVELALGVLLLLGLATRLVAGVSAALLVVFIAGIISAWSRGLAIDCGCFGTGGALPPGQTPSYLPEILRDLGFLALAGFLLIWPRTAVSVDGALTGEPVEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8K7</accession>
    <name>F4F8K7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734402.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23260"/>
    <dbReference type="EnsemblBacteria" id="AEB45750">
        <property type="protein sequence ID" value="AEB45750"/>
        <property type="gene ID" value="VAB18032_23260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23260"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_44_1_11"/>
    <dbReference type="OMA" id="AKYDMTQ"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="77" mass="8795" checksum="BDF8D3E5AD3D05C0" modified="2011-06-28" version="1">MVKPTRVTNNIRALRFAHDEMTQADLAERVGVTRQTVIAIEQGRYSPSLEMAFRIARVFGVRLDDVFQYPDTEEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8R2</accession>
    <name>F4F8R2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Capsular exopolysaccharide family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">VAB18032_23535</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734457.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23535"/>
    <dbReference type="EnsemblBacteria" id="AEB45805">
        <property type="protein sequence ID" value="AEB45805"/>
        <property type="gene ID" value="VAB18032_23535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23535"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_4_1_11"/>
    <dbReference type="OMA" id="TQVKYTP"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="17">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="18">
        <location>
            <begin position="261"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AEB45805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="485" mass="51337" checksum="F581D8BE698D13E9" modified="2011-06-28" version="1">MDLLRQLRLVRQHWWIVLVTVMVALGVTALITVRAQPRYVASVTFFVTTPSQGVTDAYQGGLFLQQRVKSYAELLTSDRLAQSAAADRQVGLTAEEIQRRVSTSTENGTVLLRASVTDTDQARALRVTEALSANFVELVQKVEAKPDGSAGPIKIEVVSGPRVTPSPVSPQPVRNTVIGALLGLLAGVGLAVLRGMADVRLRDAAALRRVTGSPLLGEIPLDGSARVAPLIVGDAATSARAEAVRKLRTNLRFVDVHEPARVIAVTSALQGEGKTTLSCNLAIALAEAGWRVLLVDADLRRPKVGHYLGVDSGVGLTDVLVGDVHVGDVVQRWGDKSLLVLPSGSAPPNPSELLGSKAMSDLLLALRESADIVIIDTAPLLAVTDGVVVAVQADGALLVSQQGRTSRAQVAAAARALHSVSVRLLGCVLNMARVPKTDAYQYEAYRVVTDTASTAAARSSAGRHAERRGPAEPVDHTQELTRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8V9</accession>
    <name>F4F8V9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoglycoside/hydroxyurea antibiotic resistance kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29841"/>
    <dbReference type="EnsemblBacteria" id="AEB47039">
        <property type="protein sequence ID" value="AEB47039"/>
        <property type="gene ID" value="VAB18032_29841"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29841"/>
    <dbReference type="eggNOG" id="COG3570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061172_2_1_11"/>
    <dbReference type="OMA" id="FDFANIF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="31807" checksum="7C8E17484386E547" modified="2011-06-28" version="1">MTGALRIPDGLTWLHGVPGGPEWLAGLPGRLAACARRWSLRVGPPFGYAFASLAVPVDLPDGTRAVLKLQFPDAESEHEATALRRWNGDRAIRLLAHAPELRALLVERCHPGTPLHALPLDEALDAVVALLPRLWVPAGQPFMSLAQAAAGWTARLPITWERAGRPYERRLLDASLDLLAGLAGSQGEQVLVNQDLHAANVLRAEREPWLVIDPKPLVGEREFSVVPMVRGTELGHSRAAVRRRLDRLSAELGLDRERVRGWTIGQTMAWSIDGGQVFTDHVEVVRWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F918</accession>
    <name>F4F918_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730720.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42046">
        <property type="protein sequence ID" value="AEB42046"/>
        <property type="gene ID" value="VAB18032_04600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04600"/>
    <dbReference type="HOGENOM" id="CLU_2721167_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="72" mass="8221" checksum="85BE8BCE41ED6AA5" modified="2011-06-28" version="1">MSRRDEEFYEADEPLDKIVDAFERGEKRVTRAPELGQTAYLKVKGRLLGRGVPVTRPTTRSENKATKELISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F921</accession>
    <name>F4F921_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730723.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04615"/>
    <dbReference type="EnsemblBacteria" id="AEB42049">
        <property type="protein sequence ID" value="AEB42049"/>
        <property type="gene ID" value="VAB18032_04615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04615"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_8_0_11"/>
    <dbReference type="OMA" id="MTTFSVH"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="254" mass="27466" checksum="4AF0CFBBFE0A8E73" modified="2011-06-28" version="1">MIGTPVGDFDYETEGQGYASQRRPDPRIAALIHTALGDARTVLNVGAGAGSYEPTDRYVVALEPSARMRGQRPATAVPALNAAAESIPFDDIAFDAVMATVTVHQWADTARGLAELRRVARGPVVVLTFDGAALDRFWLAEYAPELIAVERRRYPVISTIAEAIGTEVSVIEVPIPVDCVDGFTEAYYARPERLLDPAVRAAQSAWGFVDEAATARAVERLRGDLDSGVWEARHGHLRAQPTFNGSLRLIVGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9K6</accession>
    <name>F4F9K6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2263 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17410"/>
    <dbReference type="EnsemblBacteria" id="AEB44584">
        <property type="protein sequence ID" value="AEB44584"/>
        <property type="gene ID" value="VAB18032_17410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17410"/>
    <dbReference type="eggNOG" id="COG4295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024412_4_1_11"/>
    <dbReference type="OMA" id="AHRDPFY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="DUF2263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02452">
        <property type="entry name" value="TIGR02452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2263" evidence="1">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="27200" checksum="2B44E814433F5CA8" modified="2011-06-28" version="1">MAIAESGGYRNAAGDEVVIGEAVRAAVAGTRHHLPNEVLAVGNAAPGAGEVEVTYESTLQAAYRLGPGAACLVFASAKNPGGGFLGGAKAQEESIARASALYPCLLAAPEFYTFHRGQRDLRYSDRVIYSPNVPVFRDDKGNLLDQPYTTSFLTAAAPNLGAILRNQPEHATDVPAVLVRRARRVLQAAAAHGHRTLVLGAWGCGVFRNDPAAVAGAFADALEMVDRFDRVVFAIRDGLPGTPVYRTFVERFPELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Q4</accession>
    <name>F4F9Q4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23660"/>
    <dbReference type="EnsemblBacteria" id="AEB45830">
        <property type="protein sequence ID" value="AEB45830"/>
        <property type="gene ID" value="VAB18032_23660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23660"/>
    <dbReference type="eggNOG" id="ENOG5032RKK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139818_0_0_11"/>
    <dbReference type="OMA" id="WVGHARK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="107" mass="11822" checksum="5E358ACE024FA8AE" modified="2011-06-28" version="1">MLTDDLDGGKADRTVEFSLDGVAYTIDVSDENAGVLRKALDPFINAGRRLGRGTDTTRSVRRVAGPATPGMNREQNRAIREWAISNGYKISERGRIPVEVVEAYKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA46</accession>
    <name>F4FA46_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00365"/>
    <dbReference type="EnsemblBacteria" id="AEB47157">
        <property type="protein sequence ID" value="AEB47157"/>
        <property type="gene ID" value="VAB18032_00365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00365"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_19_0_11"/>
    <dbReference type="OMA" id="HADQPGM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="129" mass="13945" checksum="58A1887CD10D8B5A" modified="2011-06-28" version="1">MIVGAAIIEDGRVLACARSAPPEVAGMWEFPGGKVEPGESETAALARECVEELGVRVEVGERVGRNVRMAHGRSVLKVYAARLLHGDRPRALEHSEIRWLSATELDTVTWLPADTPIVAALRPLLTSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAE5</accession>
    <name>F4FAE5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von willebrand factor type a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732043.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11270"/>
    <dbReference type="EnsemblBacteria" id="AEB43372">
        <property type="protein sequence ID" value="AEB43372"/>
        <property type="gene ID" value="VAB18032_11270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11270"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024570_2_1_11"/>
    <dbReference type="OMA" id="WPQMLWL"/>
    <dbReference type="OrthoDB" id="736429at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="87"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="319" mass="34120" checksum="A8A1877BAD63720D" modified="2011-06-28" version="1">MIWESPIRLWLLLGVAALAVAYLVAQRRRSRYAVRFTNLRLLDRVAPQRPTWRRHLPAGLFLAMLALLVVGFARPTAEVRVPRERATVMVAVDVSTSMLATDVDPDRLSAAKSAARDFVDGLPREFNVGLVAFAGSAAVLVPPSTDREALHDGIRRLAEGITGVQGTAIGEAISTSLGAVKALDEQATTQPPPARIIVLSDGANTSGMDPMEAAAEAVAFEVPVHTISFGTPGGFVDRGGRPIQVPVDGETLQAVAEQTGGAFHQADTSDELHAVYDDIGSSVGWRKERQDISARFIGLGLVFAMGAAFGSMRWFSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAE9</accession>
    <name>F4FAE9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellulose-binding family II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732047.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11290"/>
    <dbReference type="EnsemblBacteria" id="AEB43376">
        <property type="protein sequence ID" value="AEB43376"/>
        <property type="gene ID" value="VAB18032_11290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11290"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044083_0_1_11"/>
    <dbReference type="OMA" id="WAAGKTT"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307760" evidence="2">
        <location>
            <begin position="25"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="280"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="384" mass="39986" checksum="AB851A29BBBE72DF" modified="2011-06-28" version="1">MLRRSLRNAAAGFAAVVLTVTAWSAPPSSTTLPSQYASPVAATAALADPVRIMPFGDSITGSPGCWRALLWNRLQSTGHTAIDFVGTLGPQGCGQPYDGDNEGHGGYLATTVANQNLLPGWLSATRPDIVLMHFGTNDVWSNIAPTTILAAYSRLVDQMRASNPTMRILVAKIIPMAPSSCPECGQRAVALNNAIDGWAAGKTTTQSPIVVVDQWTGFNTAADTYDGVHPNAAGDQKMSDRWYPALVSALTGIPTPTPTPTPTPTVTPTPTVTPTPTGPATPPPAGCVASYRLVGQWQGGFQAEVTVSNNGATPLTGWVVRLDYTDGQRVNQAWSAEVTQAGAVVTARNAAWNGTLSPGAQTTFGFLASAGSTNTTPTAHCSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAL0</accession>
    <name>F4FAL0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase 15-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733280.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17615"/>
    <dbReference type="EnsemblBacteria" id="AEB44625">
        <property type="protein sequence ID" value="AEB44625"/>
        <property type="gene ID" value="VAB18032_17615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17615"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010399_2_0_11"/>
    <dbReference type="OMA" id="WVAACPD"/>
    <dbReference type="OrthoDB" id="318658at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="222"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="594" mass="64673" checksum="0AD5D72AA568DD18" modified="2011-06-28" version="1">MAVISDYALLGDCQGAALVSSDGVVDWWCPPRFDAPSVFARLLGATGGFWSIRPLGRYTTSRHYIDGTMVLRTEFRTPTGVLRLTDALSLGAGERGHRIGFTSPHVLIRQVEATGTVDVAVEVAVRPEYGLVSPTITETPAGMDIAGAGDRLTLAADRALAVDGALVTARFTLAEGDSAVFALHHRRSADPPTAPLDGRAALRDTIAAWQSWDRLHQDYQGPYREHVRRSALVLQALTYQPTGAVVAAATTSLPEQVGGAANWDYRFGWLRDGSVTLRALWVGACPHEANRFFDWMAASIGSAGATDHIPIMFGVGGERDLTEHTLEHLEGYQNSRPVRVGNNAWQQKQLDVLGEPLECALVLRDELGDLSPAATDLLRTLADRAADTWQEPDASTWEGREGERNYLTSKLLCWVALDRAIKLASTLDAEARVPRWSQARDQIRAAILTQGWNDSRQAFTGAFGSDHLDAGLLVMPITGFLPGDDDRVVATVDAIRRELGRDDLLQRWTGAGEEGAFIICSYWLAEALARAGRLDEAKQVYENVTGHANDLGLLSEEIDRRDRSLIGNFPQALSHIGVINAAWIIGEVESGNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAZ0</accession>
    <name>F4FAZ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45953">
        <property type="protein sequence ID" value="AEB45953"/>
        <property type="gene ID" value="VAB18032_24275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24275"/>
    <dbReference type="HOGENOM" id="CLU_3349988_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="37" mass="4017" checksum="367955935E184013" modified="2011-06-28" version="1">MRAVDESAVRRLHEQVDVLSRQASGLADEPGVPSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB28</accession>
    <name>F4FB28_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_00445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735818.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00445"/>
    <dbReference type="EnsemblBacteria" id="AEB47173">
        <property type="protein sequence ID" value="AEB47173"/>
        <property type="gene ID" value="VAB18032_00445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00445"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="VVHMARM"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="32470" checksum="D5CECDB94991BEE9" modified="2011-06-28" version="1">MTLIATESLTKVYGGGVTALSELTVTVEPGIVGLVGANGAGKSTLIKLLLGLLTPTRGRVRVLGMDPTTDPAGVRARVGYMPEHDCLPPDLSAAELVTHLGQISGLPRTAARERASEALRHVGLHEERHRPVGGYSTGMKQRVKLAQALVHDPDLLLLDEPTNGLDPAGRDAMLALVHRIGTEFGISVLVCSHLLGEVERICDTLVAIDGGRLLRADHIAAMTSTTDVLAVEVSEGTETLATRLAALDLPVSREGRLLLVPLADQQTYDLIIGAVADLDLPLHRLDQRRHRVAELFARREGSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB32</accession>
    <name>F4FB32_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="8">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_00465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735822.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00465"/>
    <dbReference type="EnsemblBacteria" id="AEB47177">
        <property type="protein sequence ID" value="AEB47177"/>
        <property type="gene ID" value="VAB18032_00465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00465"/>
    <dbReference type="eggNOG" id="COG0538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_11"/>
    <dbReference type="OMA" id="HGTVQRH"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="13">
        <location>
            <begin position="9"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="309"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB47177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="45137" checksum="237864561566D45A" modified="2011-06-28" version="1">MAKIKVNNPVVELDGDEMTRIIWKQIREQLILPYLDVDLHYYDLSIQHRDATDDQVTVDAANAISEHGVGVKCATITPDEARVEEFGLKKMWRSPNGTIRNILGGVVFREPIIMSNVPRLVPGWTKPIIIGRHAHGDQYRATDFVVPGPGKVTITYTPADGAQPIEMEIANFPGSGIAMGMYNYDDSIRDFARASFRYGLDRGYPVYMSTKNTILKAYDGRFKDIFAEVFENEFKAEFDAAGLTYEHRLIDDMVAAALKWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSPDGRTVEAEAAHGTVTRHYRQWQKGEKTSTNPIASIYAWTRGLAHRGKLDGTPAVTEFANTLEQVIVDTVESGQMTKDLALLISRDAPWLTTDEFMNTLDENLARRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB52</accession>
    <name>F4FB52_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sucC</name>
        <name evidence="9" type="ordered locus">VAB18032_00565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735842.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00565"/>
    <dbReference type="EnsemblBacteria" id="AEB47197">
        <property type="protein sequence ID" value="AEB47197"/>
        <property type="gene ID" value="VAB18032_00565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00565"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_4_0_11"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="392" mass="40999" checksum="8246C3A0EA6F0E71" modified="2011-06-28" version="1">MDLYEYQGRDLFERHGLPVLAGGVATTPEEARAIAERLGGRVVVKAQVKVGGRGKAGGVKLAEGAEETVARATDILGMDIKGHTVHKVMITVTADVAEEYYFSYLLDRANRTFLCIASVAGGMDIEQVAADTPEKVVKAPIDAVKGVDEAKAREIVEAAGFPAEVADQVVETAVGLWQAFVAEDATLVEVNPLAKTKDGKLLLLDAKVSLDENAGFRHPDHEALVDQATVDPLEQAAKEKDLNYVKLDGEVGIIGNGAGLVMSTLDVVAYAGERHGNVKPANFLDIGGGASAAVMANGLEIVLSDPSVKSVFVNVFGGITACDAVANGIVQALDLLKQRGEEVTKPLVVRLDGNNAEAGRAILDGANNPLIERVDTMDGAAERAAELAAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBA5</accession>
    <name>F4FBA5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="16" type="ordered locus">VAB18032_05375</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05375"/>
    <dbReference type="EnsemblBacteria" id="AEB42201">
        <property type="protein sequence ID" value="AEB42201"/>
        <property type="gene ID" value="VAB18032_05375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05375"/>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_11"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="14">
        <location>
            <begin position="88"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="15">
        <location>
            <begin position="204"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="381" mass="40357" checksum="64CB812846437471" modified="2011-06-28" version="1">MSERSGAGSSPSGAGNDRQPWTAGSGRQARKRSVSYADAGVSIEAGDRAVELLKSKVKETRRPEVMGDLGGFAGLFRLDTTKYKNPILASSTDGVGTKLVIAQQMDIHDTVGIDLVAMVVDDLVACGAEPLFLLDYIATGEVVPDKVAEIGAGIADGCRYAGCALLGGETAEHPGVLRPDEYDISATGVGVVEESEILSSERVEVGDVVIAMRSSGLHSNGYSLVRHVLLGAGRMRLDVVIDDFGRQRTLGEELLTPTKIYAKDCLKLIAEAEVRALAHVTGGGIPGNLVRILPENVDAVVNRSTWRPQPIFDLIQSKGRIEDPEMDATFNMGVGMFAIVSAEDADRALATLTGRGVDAWQVGEIIEGTGEVQMVGQHTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBB1</accession>
    <name>F4FBB1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007073996.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05405"/>
    <dbReference type="EnsemblBacteria" id="AEB42207">
        <property type="protein sequence ID" value="AEB42207"/>
        <property type="gene ID" value="VAB18032_05405"/>
    </dbReference>
    <dbReference type="GeneID" id="5706360"/>
    <dbReference type="GeneID" id="67458537"/>
    <dbReference type="KEGG" id="vma:VAB18032_05405"/>
    <dbReference type="PATRIC" id="fig|391037.6.peg.175"/>
    <dbReference type="eggNOG" id="COG2452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196700_2_1_11"/>
    <dbReference type="OMA" id="LENSGMM"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7782" checksum="C2E6BD15ADDE11B4" modified="2011-06-28" version="1">MASRTHEPEPLLTPAEVASMFRVDPKTVTRWAKAGKLSAIRTLGGHRRYRESEVRALLQGQIPQQRQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBG3</accession>
    <name>F4FBG3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ordered locus">VAB18032_05665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730932.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05665"/>
    <dbReference type="EnsemblBacteria" id="AEB42259">
        <property type="protein sequence ID" value="AEB42259"/>
        <property type="gene ID" value="VAB18032_05665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05665"/>
    <dbReference type="eggNOG" id="COG4113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_0_0_11"/>
    <dbReference type="OMA" id="YPVEPLM"/>
    <dbReference type="OrthoDB" id="1878484at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="138" mass="14453" checksum="ACE29EAE7CEBA316" modified="2011-06-28" version="1">MGKRRVIVVDASVLADALVDDGPVGDAARAELTGDPHWAAPSHLLIEVMSVIRGKVLGGKLGLARAQEAIDTLPSLVIDEVGVATLLDRMWQLRGNVTAYDAAYIAAAELLACPLVTGDGRLAKANGVRCEIRLLATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBJ0</accession>
    <name>F4FBJ0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rlmN</name>
        <name evidence="14" type="ordered locus">VAB18032_11690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732121.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11690"/>
    <dbReference type="EnsemblBacteria" id="AEB43452">
        <property type="protein sequence ID" value="AEB43452"/>
        <property type="gene ID" value="VAB18032_11690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11690"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_0_2_11"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="119"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB43452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="383" mass="40931" checksum="082765916AE425D5" modified="2011-06-28" version="1">MTSLPLIPVDPDAPGARRASMPPQHLADLDLAGRKALVTGLGEPAFRARQISTHYFGRLVRDPAQMTDLPAASRARLADQLLPRLLNPVRELACDDGATRKALWRLHDGALVESVLMGYPDRVTVCISSQAGCGMACPFCATGQAGLTRNLSTAEIVDQAVYLAGVAASGAVVGSPARLSHVVFMGMGEPLANYNRVVAAIRRLVAPAPEGLGLSQRHITVSTVGLVPAIHRLASEDLSVTLALSLHAPDDELRDELVPVNQRWKVSEVLDAAWAYAARTGRRVSIEYAMIKDVNDQPWRADLLGRLLAGKLAHVNLIPLNPTPGSRWDASPKPVEREFVRRLRDAGVSTTVRDTRGREIDGACGQLAAAEDMGTDPAGNPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC16</accession>
    <name>F4FC16_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734666.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24580"/>
    <dbReference type="EnsemblBacteria" id="AEB46014">
        <property type="protein sequence ID" value="AEB46014"/>
        <property type="gene ID" value="VAB18032_24580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24580"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_38_0_11"/>
    <dbReference type="OMA" id="RVTVYGH"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="20754" checksum="62F274FE7DCC5383" modified="2011-06-28" version="1">MTIDGTARRADARRNVESILEAATALLATDPAVSVNEIARAAGVGRVTLYGHFPSRAALVEAVSRRVIASTDQALDAVDLDGDAREAMARLLAATWQLTYRFGAIVVAASDALTPEEMRRVHEEPARRMRALVERGRDEGVFRRDMPLSWQLTTVQAVLHGASAAVHRGDVPADDATRLVTDTVLAALAVTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC81</accession>
    <name>F4FC81_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735905.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00880"/>
    <dbReference type="EnsemblBacteria" id="AEB47260">
        <property type="protein sequence ID" value="AEB47260"/>
        <property type="gene ID" value="VAB18032_00880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00880"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="OMA" id="DRFDFMW"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="207" mass="22512" checksum="6DB84D98EDD5490F" modified="2011-06-28" version="1">MDFASYDPAGARQSRGIISAKIVVAGGFGVGKTTLVGAISEITPLTTEAVMTAAGVGIDDSSKVPGKETTTVAMDFGRITMAQDLILYLFGTPGQTRFWFMWDEIIRGAVGAAVLVDTRRITDAFAPLDYFENRRLPYVVALNRFDGAPQYELDEVREALAISPDVPLVMTDARRRESVKQVMVTVVEHAMARLQAEHDRGFPTPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC84</accession>
    <name>F4FC84_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_00895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735907.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00895"/>
    <dbReference type="EnsemblBacteria" id="AEB47263">
        <property type="protein sequence ID" value="AEB47263"/>
        <property type="gene ID" value="VAB18032_00895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00895"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002554_0_1_11"/>
    <dbReference type="OMA" id="DFADINH"/>
    <dbReference type="OrthoDB" id="811938at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="547"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="890"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1062" mass="111325" checksum="86F5B48A65319794" modified="2011-06-28" version="1">MSTGPTTLPASGDAEHNGRRRLPRLRDARIRSKLALILVVPVAAVIALATVRLVAVGEGAYEASQARSLTVLSTKISALANDLHAERMAAAAYLASTQQQVDAYNLRVRRTQERVDAYRAERARIGDVPTAVRDRLTAIDRHLDTLDGTRQEVLDRQQMQVAEAALRYGVVLADLVGYSDGLAQLPGEESLADNRRAVAAFARAKAAVAEEEAVAFTALTTGRLDTEQFSAFVATLTGQQEALLSFSLAADPTQRALVESTVSGDAVVLADRIATDITRSVGRGSPVSAQDATAAIGAVHELMRWAEGELENRLLAKTEQARSDVIRQAIVETTLVLLTLVIAVTLAVVLARSLNHSLRRLREGALSVANHDLPEAVRRLQGMGNVSDGSVDEIVREVRDPIQLNNRDEVGQVASAFNVVHREAVRVAAEQAALRSSVSAMFLNLARRSQTLVDRMIGELDAIERGEEDPKRLAQLFELDHLATRMRRNDENLLVLAGADSAVPRRDDALLVDVLRAAQSEVELYNRIEFGTVDTDVSVAAHAVNDVVRLVAELLDNATRFSPPNTTVVADGRRIRDYVLIQIEDRGLGLTDEQLDSLNKRLAAPSTVDVAAFRLMGLAVVSRLAARYGIRVELRRNVEGGTVAQITLPAATVILPSLRGRDQAITRPRQPLAVEQSPAGAGEPLAGAGRSTTATLSDRWRSAPAATPWPAADPTPQHTPPAHTSPPAYAGGFNAGTPTVASPTIDPLSYRTANAPGEPQPAAPVLPAGPVAGAPVSTANGFAPAAPNGFTPTAAPNGFTPTAAPNGFTPAAAPSGFAPTAGQGSGGGQDTPMFGGLGASLAATAPVASAPITAPPEPQAEAPIFREMEAVWFRSHGNDVTAIFSRPQFDEPPATAAAGPPATSPSAPAVEPTKGRTPLPTRTPGAAAGDASLSPPSYPTSSAASTGTPPAAPPPAAPPTPAAAPSAAAGDDAWRTAADEGWTRASQAAEPTPAGTTRSGLPKRVPQAQLVPGGIEPRTGREHSRRTPDEVRGLLSAYHRGVQRGRTAGATQNSTSTKETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCK1</accession>
    <name>F4FCK1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731001.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06020"/>
    <dbReference type="EnsemblBacteria" id="AEB42328">
        <property type="protein sequence ID" value="AEB42328"/>
        <property type="gene ID" value="VAB18032_06020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06020"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069623_3_0_11"/>
    <dbReference type="OMA" id="TVWTTYL"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="136"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="254" mass="27230" checksum="F7E9141701A5DBCA" modified="2011-06-28" version="1">MASVPSGTPCWADLATPGLDRARRFYPELFGWTGRVDPEPEAGGYTTFQLDGRAVAGVGPPAVPDQVPIWSTYVATDDADLVTGRVERAGGQVVVPPFEVFDRGRMAVFSDPAGAAFSVWQPMAFSGAEVFDVPGAMCWTELVTPDTDGARIFYELVFGWQPEEEPMGQTSYTGWRLGDRMVAGMMPPREEAFAADSPAYWTLYFSVADADATAARAAELGGTILVPPRDIPAGRVTALRDPDGALFSLIALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCN3</accession>
    <name>F4FCN3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S1 and S6 chymotrypsin/Hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_12065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732196.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12065"/>
    <dbReference type="EnsemblBacteria" id="AEB43527">
        <property type="protein sequence ID" value="AEB43527"/>
        <property type="gene ID" value="VAB18032_12065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12065"/>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030648_2_1_11"/>
    <dbReference type="OMA" id="FYSGAQA"/>
    <dbReference type="OrthoDB" id="1110723at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037295">
        <property type="entry name" value="Alpha-lytic_protease_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54806">
        <property type="entry name" value="SSF54806"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313796" evidence="7">
        <location>
            <begin position="29"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="127"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="224"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="40696" checksum="1C7106A6CB9448F0" modified="2011-06-28" version="1">MDRRRLTAIGVVVAAVGAAAAVTLPSFAGDSGAPRVPAGPAVEGADPQVVEALRRDLGLDETQVAARLKTERWASGVVDQLRTELGADYGGSWLSADGSQLNVAVADPAEAARVRAAGAVPKVVERGVGQLDALKTRMDRSAARAQQVSGWYVDVASNSLVVLAQPGAEAAGWRFVARAGVPRQAVRMATEEQPRLFADVRGGEPFFVGAGRCSVGFAVVGGYVTAGHCGRVGARTSGPDGELQGVFRASSFPGDDWAFVQVNSNTRVLPEVTDFRGGIARVAGSREVPAGSSICRSGSTTGVRCGTVQARNATVRYPEGLVSGLVRTNVCAEPGDSGGSWISGNQAQGVTSGGSGDCVRGGTTFYQPINEILQRNNLTLLTTQNFRALSGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCY7</accession>
    <name>F4FCY7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733474.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18585"/>
    <dbReference type="EnsemblBacteria" id="AEB44819">
        <property type="protein sequence ID" value="AEB44819"/>
        <property type="gene ID" value="VAB18032_18585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18585"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_557719_0_0_11"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_19_cat" evidence="3">
        <location>
            <begin position="292"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="489" mass="51839" checksum="5CCF3E0D860E2615" modified="2011-06-28" version="1">MALRKAQAARQAGSSVFKLDASQLLWLVVSVVGLFPLIVLALLALIVLLVIFAMAGGSQLTSASSDPSDTGGQTSRLNALIELSGGDGRGTFDPTKVPDEDLVAPIRAAAKECDLLTPVILAAQIDYASGFDADKEGPQGRKGLSQLAPEVFDEFGADDDDSGEASVLDAEDSIHAHARYFCHLAERTEQLRKDKKVVGDHLSLTLMAWDIGLETVEAQGGMPVLALGAYPFQVRGLFAKYTTTGDEEPDSDTAPGDPDQEPEPDDDSTTAPPGPDGTDTDETAVLSEAQFTAMFPHRNSFYTYAGLTDAMAKFPAFAGTGDEQTRKRELAAFLANINHESGGLVHVEEINQAAWGNYCDAGQPYGCPAGQTAYHGRGPIQLSWNTNYKAAGDALGLDLLHQPDLVRDDPSVAWQTALWFWMTQTGAGRMTAHSAITGGGGFGETIRTINGALECGGGNPAQVQARVEAYQRFAADLGVDPGDESTLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD22</accession>
    <name>F4FD22_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18760"/>
    <dbReference type="EnsemblBacteria" id="AEB44854">
        <property type="protein sequence ID" value="AEB44854"/>
        <property type="gene ID" value="VAB18032_18760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18760"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044949_0_0_11"/>
    <dbReference type="OMA" id="FVEDHFA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="326"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="387" mass="41487" checksum="74E0B743345547E7" modified="2011-06-28" version="1">MTVPGPAPAWRRLSADLATAMRPHLPVTVDAVAVAVTEATPAFAGIADDKFARDVRHAVQVALDRFLDLVGTDEPALPGPFREVFVALGAAEAREERGPEALLAALRMAGRQLLRTASQSLARLRPVGTEELIDLSDAVTAYVDELAAASTDGYALQLREQAGEGDRRRQLAELLLRGDGMPSAVGAAAARIGWPDLDAVVPVLLPLDQARDVRFRYGPDGLVVERGRDAVLLLRAGPRATRAALTEALAGRWAVVGPGLAWPQVPAAVRLAELAAGLLGPDPGPIFVDDHLVALALRGETGALAVLTARRLAPLADLRPAQRENLLSTLHSWLRHWGSRAEVSAELFVHPQTVSYRLKRLRELYGDQLDDPSARFELMVVLASRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD51</accession>
    <name>F4FD51_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734733.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24915"/>
    <dbReference type="EnsemblBacteria" id="AEB46081">
        <property type="protein sequence ID" value="AEB46081"/>
        <property type="gene ID" value="VAB18032_24915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24915"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_223631_0_0_11"/>
    <dbReference type="OMA" id="NRQHWNQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="992"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2057"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3116"/>
            <end position="3191"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4175"/>
            <end position="4250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="4158"/>
            <end position="4178"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1027"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2092"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3151"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="4515" mass="485567" checksum="1D61B0B2DEC0EAA4" modified="2011-06-28" version="1">[encoded data, 4515 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD67</accession>
    <name>F4FD67_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734749.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24995"/>
    <dbReference type="EnsemblBacteria" id="AEB46097">
        <property type="protein sequence ID" value="AEB46097"/>
        <property type="gene ID" value="VAB18032_24995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24995"/>
    <dbReference type="eggNOG" id="COG1813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056128_0_0_11"/>
    <dbReference type="OMA" id="DSTHPAD"/>
    <dbReference type="OrthoDB" id="935557at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="438" mass="47275" checksum="8B13E2419B33F68E" modified="2011-06-28" version="1">MSIDLPTGDTVPLFGLLVRQHRMRIGLTQRELADLSTVSVRAIRDLEQGRARRPRQDTVRLIADGLRLGARARADLESAAGEGRTSWAVKAGYEADPPAPPFAIDVQLGREPETAVIVDELATGAERLVTVVGIDGVGRTRLAIEVATRMHAADRTPVLWCPVTGPTSGDRLSTLVRAAADQLLGDSTHPADGTDAIAALVEIVADRPPLLVLDGVREVAHPGRLVQLLRDCPGLRILVTAAFPLGVPGERHFLLNPLAVADEGEPFDAHAPAVRIFMERARRYRPDVDPDARETALIAEICRRLDGIPQAIHAAASWLVVYDIATLHHCLHDGPSGLLHHLAGPDGGTSLRDALERRLSTLPTAERDLLDALCGQGETFDLAEVMALTGRSLPDSGRAVRALVLRGLVRPWYTGGQSRFRILHLVRAAQLCALDVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD71</accession>
    <name>F4FD71_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734753.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25015"/>
    <dbReference type="EnsemblBacteria" id="AEB46101">
        <property type="protein sequence ID" value="AEB46101"/>
        <property type="gene ID" value="VAB18032_25015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25015"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009955_0_0_11"/>
    <dbReference type="OMA" id="VAECELG"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="645"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="891" mass="95311" checksum="F96699638E4275B1" modified="2011-06-28" version="1">MTAELCADLVAEADAAYSRVVLDPARYTATAREIVDLARRAGNDEALIVGLRALAWTRHAVLDNETAKRLLDSAARLATRRGLHRRLGEVLLTRSVALQELGRYPAATRDLRRAAGLVSPQQRPELLMQLAILDHNAGRVRSAARQYRVVLAESACPPVIWVKAANNLSYAQTQLGRPQAALAYLDRAASLASELGPMLSAVIENSRAWSSFHAGRFTESLRRFAEAGRLYTAAGLPLGEHYLDYTDALAELRLLDEAATVARLAATDLERHGARLMAAEARLRCARLALALGDIDTARADATSAVRDFRRQRRTAWAAWAVVTAVEADAVADGFTTIAVRRLGHAAATLHRLGLRANAVEAHLVAGRAALATDDQRRGRRHLAAAGALADGQPLLVRLRGRLALALLADATARPRTTSAYRQKAATRRAAPDAGAVVRHCGAGLADLARHRAALPSVELRVLAAGHGVELGDLGLRHLLRTAPPSRVLHWLERTRAAALLTVQPAAHDDLDDLVIALRTVEQELRAARRERGPLPRTLLARQAALEAQIRRRSWGRDGKTTRSAEIVTAGQLRDLLDGEWLAEFATVDDTIVAVLVGPHRTRRIQLGALSRVEQETVALHFALRRLLHGGRYTDQARSAARTCLDTLAELLIAPLGVPPGAPLVVVPPAKLLRVPWSPLHPGPVCGAPSATMWARSRRAAESRPAGQRVALVAGPNLDGAVAEVQALEARHPRATTLLPPQSTVEAVVAALRQADLAHLACHGHLRSDSPLFSALELSDGPLTVYELHSRAVAPHRVVLAACDSGVERDYEGGEVLGFVSALMAGGTAGVIASGVPLPDGASLALMPRLHDRVVRGESLAGALWAVRAAEPPASPADFVTWCGLTAYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD75</accession>
    <name>F4FD75_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46105">
        <property type="protein sequence ID" value="AEB46105"/>
        <property type="gene ID" value="VAB18032_25035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25035"/>
    <dbReference type="HOGENOM" id="CLU_2385310_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307817" evidence="1">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="94" mass="10008" checksum="780AF32F119E9A70" modified="2011-06-28" version="1">MMLRPSVTGPQRITALLAGLLVTAIGLTTAAVPASAATVYNRFERTCTIGNQNCSKFVQTNPPYRSAFGSDCVTKRVFGADSKYHLPAGQKCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDA1</accession>
    <name>F4FDA1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25165"/>
    <dbReference type="EnsemblBacteria" id="AEB46131">
        <property type="protein sequence ID" value="AEB46131"/>
        <property type="gene ID" value="VAB18032_25165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25165"/>
    <dbReference type="HOGENOM" id="CLU_515737_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="528" mass="58779" checksum="1118FCB99EEF3A14" modified="2011-06-28" version="1">MDPVQQIGTRQNDLNDLYRITAERLHWITDRDRLRRITADPAKVSAITKAVSTWQKHNMQRAGEDEQIYEAGSTESRDYAYRQKHFETVYGPLRTALKTLKDKADEKGNERYYNKISSALDGLKLIDKGERELFKLRTSVMAPVQAELSERRRPNQGPDFEVSEGAVYADREPVEELQERLDDERPSMLRSFAQTDVLSAAAGLANCNDMADSTMAAANATLYDPMSQYGDPIYRVTYDRDHDGEDIAPEYAFPHTNVVVGPPEYPGSVQLDPWVMDPQMVNPAQSTIPEPHLYRRYGGAATGVDFRQEVRDDMPESSIDTPLTREQLRSLEVERDAREEHIRDQVGQGFVPVDHQTQMTWLADREDAADIVHIHTNSQAVYDSYHGPGQPLSPAGFLANLGNGYQVPQDHGMATNAYEAPASPTASEIEDVRARFQATRVSSIGSTTDWSSSSSSEADSVVNMSGPQFTQFQVQQQSSPRQPDVAAAARAVSGAASGSRPLAGSSRSGEQSQPGRQHPQRQARRRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDH0</accession>
    <name>F4FDH0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01485"/>
    <dbReference type="EnsemblBacteria" id="AEB47381">
        <property type="protein sequence ID" value="AEB47381"/>
        <property type="gene ID" value="VAB18032_01485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01485"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_11"/>
    <dbReference type="OMA" id="HITAQVI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="242" mass="24604" checksum="D8EE6B3A32D985C9" modified="2011-06-28" version="1">MVSGGGTGIGAAVARTLVADGCSVLVLGRRAEVLATTAERIGAETGRPEAVRAVSVDLTDPEQIGRVVEAVDGRPVDVLVNNAGGFHSAQDDTLAGIAANWRATLDTNVLTAVLLTAALRPALRRPGGRVILISSIAAQRGGGDAYSAAKAALHGWAYSLAAELGPEQITVNVVSPGYVAETEFFVGRMTPEGHAKRVAATLVGRAGTPDDIAESVRYLASPAASFVTAQILGVNGGSVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDY7</accession>
    <name>F4FDY7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12770"/>
    <dbReference type="EnsemblBacteria" id="AEB43668">
        <property type="protein sequence ID" value="AEB43668"/>
        <property type="gene ID" value="VAB18032_12770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12770"/>
    <dbReference type="eggNOG" id="COG3544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074343_1_2_11"/>
    <dbReference type="OMA" id="HTEQSVE"/>
    <dbReference type="OrthoDB" id="2064289at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="62"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="20484" checksum="053CBAD3D18C662B" modified="2011-06-28" version="1">MLALTAVLFATGCGGQHGGGGAPAPPAATASATGGPTASPALDAPRPAGSGTPAATGMAGIDLLFLSMMAGHTEQTLQIARLVHDRLADPELRTLIAAIEVTEADELATARGWLAQAGRSARADEHAGHGTGPDQLARLRDAPAGEVDRVLVEVLGAHQKGAADLARAHLAAGTDERVRDLARRIEQSRTAQVAMLAAHPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE18</accession>
    <name>F4FE18_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18925"/>
    <dbReference type="EnsemblBacteria" id="AEB44887">
        <property type="protein sequence ID" value="AEB44887"/>
        <property type="gene ID" value="VAB18032_18925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18925"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_0_11"/>
    <dbReference type="OMA" id="VAPWAPR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="55"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="29113" checksum="F2294AD5AF402D05" modified="2011-06-28" version="1">MLATTLITACAPHGARIRHTHRRQGCYAMTLHTPTPSTLRHAPFGADELAAARTDLTTGINRIFAASAMSASGHGNISVRLPGHDNLLAVNAGELLRPWPANDLRVGLPALRTVNDEVVVVDLDGEVRYGAPSPSVAAILKMHVGVYRTRPGVNAVIHTHSPHATSYALASVSLPARYEALLVHGQAVDVPVAPWAPRGTAEAVRTIAETYQAHPQTYGVLLGNHGLLVAGDDAKHAASLVVAIEEAAESSLGALALGGVTPFPDHVKDLDLRLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE25</accession>
    <name>F4FE25_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18960"/>
    <dbReference type="EnsemblBacteria" id="AEB44894">
        <property type="protein sequence ID" value="AEB44894"/>
        <property type="gene ID" value="VAB18032_18960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18960"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008670_0_0_11"/>
    <dbReference type="OMA" id="YTIEAPL"/>
    <dbReference type="OrthoDB" id="96337at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309291" description="Peptidase_M14 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="72"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="817" mass="87356" checksum="7A14EC69BA8FBB5E" modified="2011-06-28" version="1">MHTMSVRLATAGLTLALLGTAAWVAPANASALPAVPPSSPGIHQITGYPRQNVLPVWPANPADASIPIGVIPYHDIAPKLNALQATSNRVSARVAGTSSGGHDLYAVVVTAPETRQQARQQEEWKRLIEEDPVRARTDRKLLAGYKTPLFVNANIHGNEWEGTDAALRVIEEFATSRDPEVIRLLERNRLIFNVTANPDGRIAGTRANGNGYDLNRDLTIVSQPETNLIRELIIDTKPIITLDLHGYVNPTLLHPSTPPHNVNNEYDLFIKHALPNALGIEEDLRALGYAETQRARIPFRDDAPGVWDDFPPIYVPSFALLQSSIPYTIEAPLNPRGTNLTPQERVRRSGINTDVHEVAIASSLRYIQEHRNQLIFDQAEVYRRGWAGEPLRDIPDGYVPGWGPEDNYNTVFPRAYVIPTGAGQRSEPAAARLVDLLIGSGGRVWQAKQSFRANGTSYPAGSYVIDLHQPKRGLVNSLLEPGIDLTDRVNDLYAGPAAWSQGLTWGATVDTLWDAKLPKVQLKQVYDGVATGTLPPANTDVRLDIQDAADLLVVNSLIRNGLRVHRLADGSVVVQTTPSSRKLLQDAVKTHGVTFERAPARWTGTPLGEIVVGYLGGVEARDTLAALGFATRAVTAATLADTLTDDVDVLLVASSLNVANLTATNRAALDAFLARGGGVVGLGTAGASFGNATSLLSVTATAGPSLASGVANVVNRGGPVTADASAYSFISQPVWFTNLGAGVSVEQSYAADPLLAGWWARTGANGQAAAANQASIVRTVSAGGNGVVLFGTNPTFRLHPKGLHPQLGRALLWAAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEA2</accession>
    <name>F4FEA2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25350"/>
    <dbReference type="EnsemblBacteria" id="AEB46168">
        <property type="protein sequence ID" value="AEB46168"/>
        <property type="gene ID" value="VAB18032_25350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25350"/>
    <dbReference type="eggNOG" id="ENOG5031UET">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128797_0_0_11"/>
    <dbReference type="OMA" id="EAGAVDH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046211">
        <property type="entry name" value="DUF6244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19757">
        <property type="entry name" value="DUF6244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="17646" checksum="2BA5EED0076301E7" modified="2011-06-28" version="1">MIDVSSIEEIDGELRAVIAGLDRARSLTAAADHQVQQVAARAVGAGFAAVAAGMAGVRAAISVIQAGLSGAAGTVGEATRAAASVPREAATPQETIAALAQVQQAIAGAREATAATIGHVDQARQLVGTVLRGGQPGPLLQSLDSVKQVLVLVVQRCGAVQQAAEAAVGQARGLGSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEC0</accession>
    <name>F4FEC0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734838.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25440"/>
    <dbReference type="EnsemblBacteria" id="AEB46186">
        <property type="protein sequence ID" value="AEB46186"/>
        <property type="gene ID" value="VAB18032_25440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25440"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047233_0_0_11"/>
    <dbReference type="OMA" id="WALMATI"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022386">
        <property type="entry name" value="Chitin_NgcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03851">
        <property type="entry name" value="chitin_NgcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307848" evidence="2">
        <location>
            <begin position="35"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="467" mass="50216" checksum="A359B6FA2F686C3B" modified="2011-06-28" version="1">MSVNPDLNRRTLLRRAAAAGLLVTPAAGLLSACAGSTPSPSTDNTGEKSNDNPFGVQENSAVKVVIFNGGLGDAWAQEDKAIFNAKHPTVTVNMSSTQKIKTEEQPKMATTPSDVVMNSGADMMDVSTLVNEGAIEPLDDLLAAPAWDSPGTVADTLLPGTVADGTFQGKFYVVNLAYTVWGNWYNAALFSKEGWVPPKTFEEFFALAPKIKAKGMAPYVYDAVHGYYPRWALMATIWKSAGKQAVIDIDNLKENAWRAEGVLPALEQWEKVVKDKLVLPGRLDHTQSQQAWLDGKAAFIQVGTWLKNEMAATIPPGFEMKISDYWGLGATDKAPNDVYAGAGENIVVPSKAPNKAAAKEFLRAVLSKAGSAKFAELTKSLASTAGSGDNVDDPTLASANELMKNAPKDLISTKFWDFYADLDKESQNLSQELMAGRVTAAQFVDKMQAAADKVAKDSSIKKQTRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEC4</accession>
    <name>F4FEC4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734842.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25460"/>
    <dbReference type="EnsemblBacteria" id="AEB46190">
        <property type="protein sequence ID" value="AEB46190"/>
        <property type="gene ID" value="VAB18032_25460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25460"/>
    <dbReference type="eggNOG" id="COG3594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039835_1_0_11"/>
    <dbReference type="OMA" id="WTQWLTW"/>
    <dbReference type="OrthoDB" id="1211283at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="17"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="501" mass="53349" checksum="40B617428A5A1B56" modified="2011-06-28" version="1">MRRLARLAARTPADRERYLDLLRALAIVLVVFGHWMIATIYYGPHGRPDGHSALPAMPWAYPLTWVVQVMPVFFLVGGYANAASLASQRARGGDAPGWLLGRSARLLRPTTALVLVLAGSALIARLVGAEPGQVRTVVWFATVPLWFLAAYLAVVPLTPVMYALHRRFGLAVLAVLALLVALGDLGRAFGPADLALPNYLFGWLAIHQVGFAWYDARRGNCQPTGITSPTTGTRPGTEAGSKPSKSSGRTEGFARVRTRCLPMSRRAALLMIAGGLAVAVLLTGPGPYPVSMINVPGERLDNAAPPSVVLLAVATAQLGLILLLRERAERWLHRSRPWQAVIGVNSVVLTVFLWHLSAVILLVGALDALGVLPTPAAGTGAWFAWRLPWLLMLSAVLAVLVTIFGPIEARTGRSTATRHQPADQQSTGQHRPNTAQRHRWAVARGATAVAGYAAVVYAMAANSVAAKTAPDPFGLPVAALVAYLVGAGALRLLRSGWGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEG3</accession>
    <name>F4FEG3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01605"/>
    <dbReference type="EnsemblBacteria" id="AEB47405">
        <property type="protein sequence ID" value="AEB47405"/>
        <property type="gene ID" value="VAB18032_01605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01605"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1650309_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="57"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="177" mass="20644" checksum="732EE9E28AB0895E" modified="2011-06-28" version="1">MRERLAQIDLLETAPEIALPKVLLPWQSRVLWTYLQDSDLKLDLFEGFLAKLELLIEIVNSRFLHKHLRIDRDKGFVFETAQGEVVRPEQLSSGEQHELVLFYDLLFRVKAGSLVLIDEPEISLHVSWQREFLNDIVRVARLTSLRFVVATHSPQIAHKWIERTVALRPGRDREVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEL7</accession>
    <name>F4FEL7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ppx/GppA phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736093.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01875"/>
    <dbReference type="EnsemblBacteria" id="AEB47459">
        <property type="protein sequence ID" value="AEB47459"/>
        <property type="gene ID" value="VAB18032_01875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01875"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_1_4_11"/>
    <dbReference type="OMA" id="YVPKIGL"/>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="33180" checksum="FA277AB95C33ABF2" modified="2011-06-28" version="1">MRLGVLDVGSNTVHLLVVDAHRGAHPWPAHSEKAVLRLAEQLGPDGALPEAGADALVEAVGAARASATALEVDELLAFATSAVRDATNSAEVLARVQEATGVRLEVLSGADEARMTFLAVRRWFGWSAGRLLVLDIGGGSLEIAAGVDEDPDVAVSLPLGAGRLTRDRLVVDPQSAAPPGPQVVEELREYVDSLLDPVVEQMAEVSWERAVATSKTFRTLARLAGAAPSGAGIWARRRLTRGGLRQVLGFIRHIAPAQVAELEGVSAARAHQLLAGAVVAESVMRRLGVDSLDICPWALREGVILDRLDRLAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FES0</accession>
    <name>F4FES0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-phosphoglucomutase family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731137.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06700"/>
    <dbReference type="EnsemblBacteria" id="AEB42464">
        <property type="protein sequence ID" value="AEB42464"/>
        <property type="gene ID" value="VAB18032_06700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06700"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_4_0_11"/>
    <dbReference type="OMA" id="TQTAKVH"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="250" mass="26292" checksum="88AD25FD3897B11B" modified="2011-06-28" version="1">MLGLPDHVTACLFDLDGVLTQTARVHNAAWTETFDDFLRRHADAGGTPYQPFDPGADYHRYVDGRPRLDGVRTFLASRDITLPEGTAEDPPGAQTVHGLGNQKNAQVLERIRSVGVDVYPGSVAYLKAVAAAGLRRAVVTASANGREVIAAAGIEPLLEERVDGLTARAEGLRGKPHPDTFLAGAKLLGVQPEQAAVFEDALAGVEAGRAGGFGYVIGVDRAGQADALRAHGADVVVTDLAELLEAGRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEW6</accession>
    <name>F4FEW6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732346.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43678">
        <property type="protein sequence ID" value="AEB43678"/>
        <property type="gene ID" value="VAB18032_12820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12820"/>
    <dbReference type="eggNOG" id="COG4312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066898_1_1_11"/>
    <dbReference type="OMA" id="LIAYFHM"/>
    <dbReference type="OrthoDB" id="1567592at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="235" mass="26732" checksum="1FA8DF037BFCC73A" modified="2011-06-28" version="1">MTAIPASSAAAPPVVDRETWLRERDELLVREKAHTREGDAIAAARRQLPMTLMPTVTVRGPGGDTPLVEVFEGRRMLIAYFHMWHDGKPYEQQCEGCTFSTCHMQMLDYLHARDVTYAVFCEGPYDESARFAEFMGYRFPWYSARDSDPALADGRGSGFIACYLRDGDKVYETYWTTGRGVEALTTTYHALDLTVYGRQENWENSPEGWPRVTGHPWRLNGRPTAQWSRPGVAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF74</accession>
    <name>F4FF74_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate ABC transporter, periplasmic sulfate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_19385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733634.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19385"/>
    <dbReference type="EnsemblBacteria" id="AEB44979">
        <property type="protein sequence ID" value="AEB44979"/>
        <property type="gene ID" value="VAB18032_19385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19385"/>
    <dbReference type="eggNOG" id="COG1613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055615_0_1_11"/>
    <dbReference type="OMA" id="KDFGGWK"/>
    <dbReference type="OrthoDB" id="1111285at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309311" evidence="6">
        <location>
            <begin position="29"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="339" mass="35409" checksum="20A5581A092A0C6E" modified="2011-06-28" version="1">MRLRIRTAIAAAMVTGLALSGCGGGTSASDSSTLNIVGFAVPEAANKAIAAEWNKTEAGKGVRFKSSYGASGDQSRAVVSGLKADYVHFSVSSDVTRLVDAGLVDESWDDGPNKGIVSSSVVVLAVRKGNPKNIQGWDDLIKPGIGIVTPNPASSGAARWNALAAWGHIAANGGTDAQAQEFLTKLFANVVSLPGSGRDATTTFLGGTGDVLLAYENETILARQNGEDLDWILPPTTILIQNPGAVLKDADPKAKEWLDFVLGPQGQRQFALTGFRPIIDGVDTSGIEGALDPANPFPAPQKLLTVDTDFESWSALSKKFFDENEGIITKVIAASGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF88</accession>
    <name>F4FF88_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733648.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19455"/>
    <dbReference type="EnsemblBacteria" id="AEB44993">
        <property type="protein sequence ID" value="AEB44993"/>
        <property type="gene ID" value="VAB18032_19455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19455"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_2_11"/>
    <dbReference type="OMA" id="YHLMGEN"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="268"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="513" mass="54636" checksum="7633897636E1E312" modified="2011-06-28" version="1">MSATRQAPSAGPVGDDQPVVEAVNVTKRFGSTLALSEAGIVVRRGETHALVGRNGAGKSTLVGILTGLQAADEGRVLFAGAPAPPLGDRDAWRRQVACVYQKSTIIPALTVAENLFLNRHARGPGRLIRWNTLRRQAQELLAEWSVDVDVRQPAATLTVEQRQFVEIARALSFGARFIILDEPTAQLDGAGIGRLFARIRDLRAQGVTFLFISHHLQEIYEICDQVTVFRDARHIVTAPVAQLSRPALVAAMTGEDVSMPEAAPRPPSREVPVLLSVRDLVTASGAHLSLEARVGEVVGIAGGGGSGKVEVAEAIVGLARPAGGTVTLDGRRLRPGSVPDALAAGVGLVPQDRHREGLVPLLSIAENVTMTVPHRVGRRGLISPARRDALARQSIADLAIKAAGPQVPVAELSGGNQQKVVMGRALASDPKLLVLITPTAGVDVRSKQTLLGVVEQVRRRGTTVLVVSDEVDDLRICDRVLVMFQGRVVREMAHGWSDNDLVAAMEGVDLHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFA6</accession>
    <name>F4FFA6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.4" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733666.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19545"/>
    <dbReference type="EnsemblBacteria" id="AEB45011">
        <property type="protein sequence ID" value="AEB45011"/>
        <property type="gene ID" value="VAB18032_19545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19545"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_0_11"/>
    <dbReference type="OMA" id="PIFGTTH"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008742">
        <property type="term" value="F:L-ribulose-phosphate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="224" mass="23858" checksum="2014D0C18CE8C215" modified="2011-06-28" version="1">MIERELRETVARLHGELTRYGLVAWTAGNVSARVPGRDLMIIKPSGVDYDDLSADNMVLCDLDGVPVEGDLSPSSDTAAHAYVYRAMPEVGGVVHTHSTYATAWAARGESIPCWLTAQADEFGGEIPVGPFALIGGDDIGKGIVSTLTGHRSPAVLMRNHGVFTIGRTARAAVKAAVMCEDVARTAHLARALGQPVPMAQADIDALYDRYQNVYGQRPAPATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFE5</accession>
    <name>F4FFE5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734899.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25745"/>
    <dbReference type="EnsemblBacteria" id="AEB46247">
        <property type="protein sequence ID" value="AEB46247"/>
        <property type="gene ID" value="VAB18032_25745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25745"/>
    <dbReference type="eggNOG" id="ENOG5032IS2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1142207_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="140"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="243" mass="24523" checksum="C6EB574DCC6F3A2B" modified="2011-06-28" version="1">MAVRPVGDESGEPTSRRIVPNVIASAPWVATLVGVAVLALLLVVAMLSFREPEQPAAWSPGPPLVLPQQESTPTTTPTRGSGPTATPTTVPTRSAPTRSATSGPSVPPSPNASSARAADEPSASAAPTAKPSTFLDLGGVEATYQVMTSDPGSFQAELVISNDTAGAVGWVVDLRFTSEVTGVRASSGPGVSVGIKGAGWYVLSGTGQLAAEAQQTVRLRVSRTGGGEYPAQCTVNGSACALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFL4</accession>
    <name>F4FFL4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02035"/>
    <dbReference type="EnsemblBacteria" id="AEB47491">
        <property type="protein sequence ID" value="AEB47491"/>
        <property type="gene ID" value="VAB18032_02035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02035"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081826_0_0_11"/>
    <dbReference type="OMA" id="GWAYLRQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="31262" checksum="D5CB176AB4737ECE" modified="2011-06-28" version="1">MVRAFRWPPPPDGGPRTWGPGPGGPRSGRPALPEPDTELVATPHGVRLERLVTGTGDPVTVFAHGLGNGIAVTRPFGSGVTGRKVFFQFRGHGRSDAPEGLWSYLDLSRDLRAVADLSGATRAFGASLGAGALCRLLVESPERFERLIFFLPAALDQPRPPVARTRLLELLSAVESGDASAVAEVVAAEMPPAVRNTPAGWAYLRQRLDHLLRDGLAAGLADLPGQAPVTDAGALGAVTAPALIIACEGDDLHPVEVAEQLAAALPQATLHRYARPGVLWTERADVRARISEFLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFR9</accession>
    <name>F4FFR9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736179.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02310"/>
    <dbReference type="EnsemblBacteria" id="AEB47546">
        <property type="protein sequence ID" value="AEB47546"/>
        <property type="gene ID" value="VAB18032_02310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02310"/>
    <dbReference type="eggNOG" id="ENOG5032UK2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060528_1_0_11"/>
    <dbReference type="OMA" id="WRNTYDD"/>
    <dbReference type="OrthoDB" id="1802502at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307703" evidence="2">
        <location>
            <begin position="43"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="235" mass="24036" checksum="543716908976D9AF" modified="2011-06-28" version="1">MCGIRRTTPATATKRRTRPYRRSVGALATLALLAGCASTPDAGDTTAGATDAPPPVATPSTGTPPTAGTTAPGPCPAEGVRINSLGVSAAMGLRAMGLELVNCGSRPYRLHGYPQLRLLDSDDNPIKVRVIAGARGITSGFDDPPRPLTLAPGEAAGAAVLWRNLVDDPTVVATNAQRLEVAPAEGEPTQEVAVEGPIDLGNTNRVGVSAWKKQPPTSALPPATPLAPTTVPPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFU2</accession>
    <name>F4FFU2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06990"/>
    <dbReference type="EnsemblBacteria" id="AEB42522">
        <property type="protein sequence ID" value="AEB42522"/>
        <property type="gene ID" value="VAB18032_06990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06990"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_12_0_11"/>
    <dbReference type="OMA" id="EYMEGFL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="118"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="37114" checksum="2BD54FC0A4B73656" modified="2011-06-28" version="1">MAERTGVRQRPQMDLASVMRLAELTDLIVPMTVRAVSDLGVADLLVDGPRPVAELAAEVGAHERSLCRALRALAAKGIFTEPEPEVFALTPLAQPLRSDHPMSMRAVYTLLASDVQAWAMLPHSLRTGEAAFDHAHGTDYWSHLAANPDESRRVDRWMHAITRLHLRTVLPCHPWGELSHVVDVGGGDGGFLAGLLGRYPAMRGTLLDLPHVVAAADRVLTEAGVRDRCEIVPGSFFDALPAGADAYLLKTVLPGFGDDQVVAVLRRVREAMRPDSRLLLLEAVLPPGDTFDVAKLYDVHTLVLTGGTHRTAEETAALLDRAGLRLDTVRPTATLTILTATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFV7</accession>
    <name>F4FFV7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07065"/>
    <dbReference type="EnsemblBacteria" id="AEB42537">
        <property type="protein sequence ID" value="AEB42537"/>
        <property type="gene ID" value="VAB18032_07065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07065"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_9_11"/>
    <dbReference type="OMA" id="MDHYRGQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="3"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="417" mass="47463" checksum="F751066FEE2B6B5D" modified="2011-06-28" version="1">MGQRLLWLMDHYRGQQHSLNEQVVWHLRGACDVVALQRAVDLLHERHESLRTTFVARKRQLVQVINPPRPVELLRVDTSGHANPRQAAREHIATELSTAVDFGVWPTRPTLITVGPEHHIFVLTMHHYVSDDWSNALLSRDIRALYQGEELPEIGWQYATWADWQRERISGPDSTALFDHWRGQLDGARLVRLPERAEVPRGPDEPAWVSVELTIDAHVVQGLHQLARRQRTTLFPVMLSLFYLVLHRATGQSDLTVASLFANRSRPEVRDTVGFFVSMVLLRGRVEDAEPFTDLLRQVRNVVMEGLRHQELPAQLLPPGTVTGEGRTDDVMFQLLGSFVPRADMSGDELDDLEAQLERSRFALEFVVVPQDETLTAVLMCDRDRFTPDWAQQLVKDYVQLAAAVVADPHRLPASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG92</accession>
    <name>F4FG92_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733685.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19640"/>
    <dbReference type="EnsemblBacteria" id="AEB45030">
        <property type="protein sequence ID" value="AEB45030"/>
        <property type="gene ID" value="VAB18032_19640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19640"/>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="LSNARWK"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="63" mass="6568" checksum="1E02B831D51C1E71" modified="2011-06-28" version="1">MGLTGARWRKSSRSSGNGGACVEVADNLSGVVLVRDSKDRDGGMLAFGPAAWKAFVAQVTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGK0</accession>
    <name>F4FGK0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26185"/>
    <dbReference type="EnsemblBacteria" id="AEB46335">
        <property type="protein sequence ID" value="AEB46335"/>
        <property type="gene ID" value="VAB18032_26185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26185"/>
    <dbReference type="eggNOG" id="ENOG5033M6H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032983_0_0_11"/>
    <dbReference type="OMA" id="RMELRTG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="523" mass="55219" checksum="5FEC5AC4F9D58ECA" modified="2011-06-28" version="1">MENSSRPTSGARSDNRHRAGPRRHRAGIGPPAGIGLDGSPAAGLPGRAGTRRAALSHRLLASATDPTGADAADDDHAGADEARQRSARRRRLTLTGLALTAVLSAVMLVVTLVTWPPDEPAARDMTSAERDRLAVMRVTNQRDLRAGLHVTIGTGTNRTDLLGWVDWARQLVYVDVGGPGAGALRGLAQASPAVLVSRPDPTAVPAPAMPPLIPPVDGWRIPAEQRLTPLLTMIFALSAERPDPADDLSGRWVGRDRRNGEDVDILEAAPPGTGAAGTTRYWLDSAGRLHRLETTVAALGRVTVHLNRADRPTLRPVDALGGRPGLPRALTTAERDRWLHLPARLRAAGGAAVTLTVPASADANLRGTGWLSWTSGTAYLGVTDLDSPDSPRTLVRRDRTGVTRIDASASDDQAGPPPLPPPATGWRAGAHRTDALDPLVARALRAARGGGPTGNPHRVRGDNLAGTVVDVVEVGTGAGRTRYWIDRSGLLRRLELPSKAGAWAQLDLTPGRVPSLTRPTKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGR3</accession>
    <name>F4FGR3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_02445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736206.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02445"/>
    <dbReference type="EnsemblBacteria" id="AEB47573">
        <property type="protein sequence ID" value="AEB47573"/>
        <property type="gene ID" value="VAB18032_02445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02445"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="MADRMMI"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="363" mass="39619" checksum="57DF64482E0338F2" modified="2011-06-28" version="1">MATVTYAKASRIYPGTERPAVNQLDLQIGDGEFLVLVGPSGCGKSTSLRMLAGLEDVDDGAIYIDDRDVTHLPPKARDIAMVFQNYALYPHMTVYENMAFALKLRKTSKSEIDRRVKEAAALLQLEEYLNRKPKALSGGQRQRVAMGRAIVREPQVFLMDEPLSNLDAKLRVQTRTQIASLQAKLGITTVYVTHDQVEAMTMGHRVAVMLDGVLQQVDTPRALYDTPANVFVAGFIGSPAMNIKTVPLTEQGAAFAEMFIPLTREQVEAANAEGGAGKVTVGFRPEDCDIVSPTEGGMPVVVELVEDLGSDANVYGHAALDGASERFVVRTDRRTMPNMGETIFVKPRAGQNHAFHATTGKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGT7</accession>
    <name>F4FGT7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative phenylalanine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat</name>
        <name evidence="5" type="ordered locus">VAB18032_02565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the transamination reaction in phenylalanine biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736230.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02565"/>
    <dbReference type="EnsemblBacteria" id="AEB47597">
        <property type="protein sequence ID" value="AEB47597"/>
        <property type="gene ID" value="VAB18032_02565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02565"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_3_11"/>
    <dbReference type="OMA" id="YPDMACT"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01513">
        <property type="entry name" value="Phe_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024892">
        <property type="entry name" value="Pat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="41"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="366" mass="38717" checksum="67F54BBF9CE9BC48" modified="2011-06-28" version="1">MTDTGRQPTVRLTRADLDALPNYVPGRSPADLARELGLPEAIKLASNEVPYGPLPGVVEAVAEAAAGVHRYPDMGVVALRQALADRYGVDPDRIATGCGSVALAEHLVRATCLPGDELVYAWRSFEAYPIIAATSGATSVKVPNDAGHGHDLAAMAAAVTDQTRMILVCNPNNPTGTALRRAELDRFLDDVPDDVLVVIDEAYREFVTDPEVPDGLTYADRPNVAVLRTLSKAWGLAGLRIGFLVAQPQVAAAVRKVVTPFSSSMAAQAGALAALAQADEMERRCALVVAERERVTEALRKLIPDVPASQANFVWLPLGERALEFGKACEARGVIVRPFPGDGVRVTIGTPAENDAFLAAAEAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH22</accession>
    <name>F4FH22_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07580"/>
    <dbReference type="EnsemblBacteria" id="AEB42636">
        <property type="protein sequence ID" value="AEB42636"/>
        <property type="gene ID" value="VAB18032_07580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07580"/>
    <dbReference type="eggNOG" id="ENOG50326UN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1651447_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="160" mass="17066" checksum="5A440718D52592C7" modified="2011-06-28" version="1">MPAIRRPKGQPVAPNPYPGSRSRRPSDRTPVPDDVTDRLLWALAVDVAAAHQPGPDGLCTNLQCRGQHGPCWALRTAHRAHRHARRTPATFGESRSPAVGAVRGRAPVPAPSVPAPSGRFTGWFTPTHPPAPLTRLTPIADAVPPESRGHRRPPVAAMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH40</accession>
    <name>F4FH40_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS630 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07670"/>
    <dbReference type="EnsemblBacteria" id="AEB42654">
        <property type="protein sequence ID" value="AEB42654"/>
        <property type="gene ID" value="VAB18032_07670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07670"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041125_3_1_11"/>
    <dbReference type="OMA" id="ISCEDEA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="173" mass="19783" checksum="65C1148A48629CE5" modified="2011-06-28" version="1">MGRRPEVFVRQVSMAEGQRLQRITRTAKDPVKLRRAIVVLMSAQGQPAPDIAHLLKATEDYVRDVIHAFNERGFDALDPKWSGGAPRRIDEQIGDWICVIARCDPRFLGKPFSCWSLAKLRDYLVETGYVTTVSVETLRRILHERGVSWQATKTWKASTDPDFTTKMRTILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHN0</accession>
    <name>F4FHN0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_26621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735050.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26621"/>
    <dbReference type="EnsemblBacteria" id="AEB46399">
        <property type="protein sequence ID" value="AEB46399"/>
        <property type="gene ID" value="VAB18032_26621"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26621"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_7_1_11"/>
    <dbReference type="OMA" id="CGLFTPR"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004377">
        <property type="entry name" value="ABC_transpt_DrrB/DrrC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00025">
        <property type="entry name" value="Mtu_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="7"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="26892" checksum="4A70BC6619960085" modified="2011-06-28" version="1">MNSRILVATVGRILRQLRHDRRTVALLVVVPTVLLTLVYYMYADQPSVPGTSSAFDRIALVMLGFFPFIIMFLVTSIAMLRERTSGTLERLLTTPLAKADLLFGYGIAFGLAGAVQATIASAVAYWVFDLHTAGSSGLVIMIAALNAVLAVALGLLCSAFARTEFQAVQFMPVVVAPQLLLCGLFVPREQMAGWLQAVSDALPLTYAVEALQEVGAHAEPTATMWRDVAVVAAVAVLALLLAAATLRRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHT4</accession>
    <name>F4FHT4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26901"/>
    <dbReference type="EnsemblBacteria" id="AEB46453">
        <property type="protein sequence ID" value="AEB46453"/>
        <property type="gene ID" value="VAB18032_26901"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26901"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039939_0_0_11"/>
    <dbReference type="OMA" id="LMNQLRW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="41759" checksum="DC5DE3EA466E2BA8" modified="2011-06-28" version="1">MTDTTATPGVTAVPHPGGSERVQGSLLAPVTPEYGGRSLADVLPSALAVLGVPGGTDLLGLADELAGVRRVAVLLVDGLGWHQLPIAAPYAPTLAGLTATTGRPLTCGFPSTTPTSLVTLGTGTASGAHGVLGFTLRVPGTDRVLNHIEWTDDPPPMRWQPVTTALQRARAAGVAVTVVSRPEFGGSGLTVAANRGGDYRGAAGVDALAATMLAALTAGTGPTLVSGYHPDVDRHGHLSGVDSVPWRTAVTDLDALLARLVDGLPSDAALLVTADHGQLNVPAEHRFDLDTDPRLTAGLQVVAGEPRVRYLHVVPGATEDVRAAWSQVLGPAARVLTRDEAVATGWFGPVSEEHLRRIGDIVVVCNDTYAVLASRSESPMLSRLVGFHGADTAAEMTIPLLVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHW3</accession>
    <name>F4FHW3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ordered locus">VAB18032_02860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736288.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02860"/>
    <dbReference type="MEROPS" id="M41.015"/>
    <dbReference type="EnsemblBacteria" id="AEB47656">
        <property type="protein sequence ID" value="AEB47656"/>
        <property type="gene ID" value="VAB18032_02860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02860"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_1_11"/>
    <dbReference type="OMA" id="QYGMTER"/>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="204"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="212"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="671" mass="72904" checksum="0FDE661DCA07C3FF" modified="2011-06-28" version="1">MERTRFFRRPVFWVILVILGAVVLSQLFTSGPSYHRVDTSVALDQLNKGGIEKVVFQDKEQTIQLELAQEAEFGKTTTKLIEAQFPYEVGNEVWNQVLDAKANNRVTGPADTEVSSDSIWVSLLVNLLPIVLLVLLLLFFMSQMQGGGSRVLNFGKSKAKMITKDTPKTTFADVAGAEEAVEELHEIKDFLQNPGKYQALGAKIPKGVLLFGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKANAPAIVFVDEIDAVGRHRGAGMGGGHDEREQTLNQLLVEMDGFDVKGGVILIAATNRPDILDPALLRPGRFDRQIPVDAPDMEGRKAILRVHAKGKPFTPDVDLDSVAKRTPGFSGADLANVINEAALLTARKDQRAISNESLEESIDRVIAGPQRRTRVMSDQEKKITAYHEGGHALVAWALPHAAPVHKVTILSRGRSLGHTLVLPTEDKYTQTRAEMIDTLAYALGGRAAEELVFHEPTTGAGNDIEKATALARAMITQYGMSSKLGAIKYGTSGDEPFLGRNMGHERDYSDAVAAEIDGEMRALIELAHDEAWEILVEYRDVLDNIVLELMEKETLSTADMARICARVVKRPPMAPYNGFGKRQPSTEPPVLTPAEKEALKVQAEADGAQATVGSPNSNNSDGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F191</accession>
    <name>F4F191_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732594.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14075"/>
    <dbReference type="EnsemblBacteria" id="AEB43927">
        <property type="protein sequence ID" value="AEB43927"/>
        <property type="gene ID" value="VAB18032_14075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14075"/>
    <dbReference type="eggNOG" id="ENOG5033IBR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1282005_0_0_11"/>
    <dbReference type="OMA" id="VKINPHF"/>
    <dbReference type="OrthoDB" id="1844263at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="23421" checksum="50F14168BD696ED9" modified="2011-06-28" version="1">MTAPISAPLTPYATLLGFTRYVDRTGPTKASFVGGLRRQRASRSGFNPHGQFVKALKADIAFHTGGTHLAQVVDVVKPRWRPLYQALVPGATAWLHSLGEPREVDLAQTRDALALLGDLPVKINPHFGVRHCDGRAEAVRLYFDETPPSEEAALATLHLMARHMDAVLPHAEPILVDVRRGVTHRMPESAKSDEIERWLAGEAAAFRAIWSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1N7</accession>
    <name>F4F1N7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26946"/>
    <dbReference type="EnsemblBacteria" id="AEB46462">
        <property type="protein sequence ID" value="AEB46462"/>
        <property type="gene ID" value="VAB18032_26946"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26946"/>
    <dbReference type="eggNOG" id="COG2324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058217_0_0_11"/>
    <dbReference type="OMA" id="WDVVMDP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="PTHR39419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="29324" checksum="3D67DFCCEA6DE7FC" modified="2011-06-28" version="1">MTRAYAWGMLALLVLAQICYPLTSGTTRARLTVATVVLGYLLSVGHALLSRGPRTAFALIALASGGGFAIEALGVATGFPFGSYDYSGQLGPKLAGVPLIIPLAWTWMTWPAWLVATRLIGGGTAREWWRWPARIGLATLGLATWDLFLDPQMVAEGHWVWRDATPALPGLAGIPVSNYLGWLLFGVLVMTALRPLAGAAVADTDARDRPMYALYLWTYASSVLAHAVFLDLPASALWGGVGMAVIAVPLAVTLLRARRTGDDHAGAELTRADVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2C6</accession>
    <name>F4F2C6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732665.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14430"/>
    <dbReference type="EnsemblBacteria" id="AEB43998">
        <property type="protein sequence ID" value="AEB43998"/>
        <property type="gene ID" value="VAB18032_14430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14430"/>
    <dbReference type="eggNOG" id="ENOG5032SHV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106273_0_1_11"/>
    <dbReference type="OMA" id="QKGKHAG"/>
    <dbReference type="OrthoDB" id="2071791at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="16079" checksum="381237D63175CC74" modified="2011-06-28" version="1">MADVANIRTSHNGRTSHNGKTAHLGSEPSTAELVQRAAEQVSRLVRDELTLARAELTEKGKRAGIGAGLLAGGGAFAFFGLGALVTTAILLLALVLPAWAAALIVAVAMFLIAGVLALIGRRQVSRAVPPVPQATVRSLRADVDVVSAAVKDRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2F2</accession>
    <name>F4F2F2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein VAB18032_14560</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732691.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14560"/>
    <dbReference type="EnsemblBacteria" id="AEB44024">
        <property type="protein sequence ID" value="AEB44024"/>
        <property type="gene ID" value="VAB18032_14560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14560"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_11"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="26476" checksum="140D8D13A6C94BBB" modified="2011-06-28" version="1">MSGHSKWATTKHKKAVIDAKRGKMFAKLIKNVEVAARTGGGDPAGNPTLYDAIQKAKKNSVPNDNIDRAVKRGSGLEAGGADYQTIMYEGYGPNGVALLIECLTDNRNRAATEVRTALTRNGGSFADAGSVSYMFSRKGVVIVPKADTSEDDVMLAVLDAGAEEVNDLGEAFEVVSEPGDLLAVRTALQDAGIEYESAESSLIPSVNVPLDEEGARKVFKLIDVLEDCDDVQNVYANFDVSDEIMAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2J2</accession>
    <name>F4F2J2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hisS</name>
        <name evidence="12" type="ordered locus">VAB18032_14760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14760"/>
    <dbReference type="EnsemblBacteria" id="AEB44064">
        <property type="protein sequence ID" value="AEB44064"/>
        <property type="gene ID" value="VAB18032_14760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14760"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_11"/>
    <dbReference type="OMA" id="YQIQKVW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB44064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="424" mass="46039" checksum="7DF36EFF9982159F" modified="2011-06-28" version="1">MIEQYVLDRIRSTFELYGFAPLETRAVEPLDQLLRKGETSKEVYVIRRLHGDPEGPSGDDTLGLHFDLTVPFARYVLENAGKLNFPFRRYQIQKVWRGERPQEGRYREFLQADIDIVDRDTLAPHYEAEMPLVIGDALRSLPIPPVRIQVNNRKICEGFYRGVGLTDPEAALRAVDKLDKLGPAGVTELLATTAGASDAQAKAVLALAEISAPDPSFADAVRGLGVSDPLLDEGVEELVRVVETAAAHSPGLCVADLRIARGLDYYTGTVYETQMIGYERFGSVCSGGRYDNLASAGNVRFPGVGISIGVTRLLGLLFGADALSVSRSVPTCVLVAVTSEEQRAASNRVAEALRSRGIPTEVSPSAAKFGKQIRYAERRGIPYVWFPGTDGAPDEVKDIRSGDQVAAAAGEWTPPQADLKPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2R5</accession>
    <name>F4F2R5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733984.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45330">
        <property type="protein sequence ID" value="AEB45330"/>
        <property type="gene ID" value="VAB18032_21150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21150"/>
    <dbReference type="eggNOG" id="ENOG502ZF0T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208506_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="60" mass="6233" checksum="210E82A98D78E030" modified="2011-06-28" version="1">MPITLNDELRELETETFEIEEVADGEEMLAATSSSCSCSSCCSCSTSSCCSTSTSTSSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F388</accession>
    <name>F4F388_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ispE</name>
        <name evidence="12" type="ordered locus">VAB18032_08470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08470"/>
    <dbReference type="EnsemblBacteria" id="AEB42812">
        <property type="protein sequence ID" value="AEB42812"/>
        <property type="gene ID" value="VAB18032_08470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08470"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_1_1_11"/>
    <dbReference type="OMA" id="ACDALWG"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="11">
        <location>
            <begin position="231"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB42812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="33459" checksum="0F37FE55254A3F31" modified="2011-06-28" version="1">MRTGWHPVTEAWRPGDDDERRGATGPVRVRVPAKVNLHLGVGPLRRDGYHELNTVYHAISIYDELTARRGDTLTLTMEGEGTGELALDDSNLVIRAAHALAGYAGVMPHARLHLRKQIPLAGGLAGGSADAAATLVACDALWGTGLSRDELADIAADLGSDVPFLIHGGTALGTGRGEAISPVLARPTSWHWVVAIADGGLSTPQAYRELDRLREAGAAGPALGSTDALLGALRQRDPRVLARTLGNDLQDAALSLRPSLAATLKAGEAAGALAGIVSGSGPTCVFLAADAADAERVAAELTAAEVCRHVRTAHGPVHGARIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3C0</accession>
    <name>F4F3C0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymidine phosphorylase</fullName>
            <ecNumber evidence="6">2.4.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">deoA</name>
        <name evidence="6" type="ordered locus">VAB18032_08630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.4" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08630"/>
    <dbReference type="EnsemblBacteria" id="AEB42844">
        <property type="protein sequence ID" value="AEB42844"/>
        <property type="gene ID" value="VAB18032_08630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08630"/>
    <dbReference type="eggNOG" id="COG0213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025040_0_1_11"/>
    <dbReference type="OMA" id="DVWRRMI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="326"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="415" mass="42709" checksum="A3E9952A06ED283C" modified="2011-06-28" version="1">MKRDGGVLSDSQIDWVVDAYTRGAVADEQMSALAMAILLNGMTAPEIARWTAAMIASGERLDLSSVARPTVDKHSTGGVGDKITLPLTPLVAACGAAVPQLSGRGLGHTGGTLDKLESIPGWRAALSNQEFIAQLRDIGAVICAAGSGLAPADRKLYALRDVTGTVEAIPLIASSIMSKKIAEGTGALVLDVKVGSGAFMKSVDDARQLARTMVELGGAHGVKTVALLTDMSTPLGLTIGNGVEVTESVEVLAGGGPADVVELTLALAREMLDAAGLTDADPAAALRDGRAMDVWRSMIRAQGGDPDAPMPQAPEVEVVRADADGYVAGVDAYAMGVAAWRLGAGRARKEDPVSVPAGVVLHKRPGDPVRAGEPLYELRAERAETIPAALAEAASAVTIEARPPAATPLVIERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3G4</accession>
    <name>F4F3G4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14800"/>
    <dbReference type="EnsemblBacteria" id="AEB44072">
        <property type="protein sequence ID" value="AEB44072"/>
        <property type="gene ID" value="VAB18032_14800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14800"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087580_2_1_11"/>
    <dbReference type="OMA" id="TGRQRWW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="21111" checksum="E4D5247CB413A2F5" modified="2011-06-28" version="1">MRIDGRQVRALAHPLRTRLLGALRIKGPATATGLAELLDTNTGATSYHLRQLAEVGLVVEEPDRGTGRQRWWRAAHDVTNWENTDFDDDPDARAAIEWIQAEQVRQYAEQAERWFAVRDQWPPAWRDAFGMSDIFMTIPVTRLAELRTQVWQVLERYRAEADPAEPGAEQVQIFLAALPLLIGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3G5</accession>
    <name>F4F3G5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732740.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14805"/>
    <dbReference type="EnsemblBacteria" id="AEB44073">
        <property type="protein sequence ID" value="AEB44073"/>
        <property type="gene ID" value="VAB18032_14805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14805"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_5_0_11"/>
    <dbReference type="OMA" id="VELFWGF"/>
    <dbReference type="OrthoDB" id="1408909at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="477" mass="48211" checksum="0140D1E9FEF58244" modified="2011-06-28" version="1">MNPLSVRQVRRRYLVLHGLRWLPVGLLIPVTILLMQERGLTLTQIGLAIAAQGVVVLALELPTGGFADALGRKPVLVVASLVGLVSTGLLVVADSFALLVAVWALQGVFRALDSGPLESWYVDTTLAADPDARYENGLGQGGTVLGLAMAAGALLSGALVALGPIGPLSALTGPVIAAVGLQVVYLVALLALLTERRAVTGPAALRASVREAPRMVGEAFGLLRRSRVLLALVAVELFWGFGMATFEGLLPIRLAEVVADADRAATLLGPASTAAWLASAGGAALTPLLIRRLGAAPGAALLRILQGITVVGMALFAGPTGVLIAFVACYAVHGASNPLHMGLLHRQVAGPYRTSLISLNSMVAMPAGALGGVVLGYIGDRAGVSTAMLVGAVVLAVAAPLYLPAWRAGRQSADDGRDAGVPDTGPSPGDGESAARPSGDSVPAAGPPGVPVARLAGDGEPAAGQAQRTEVSGKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3I4</accession>
    <name>F4F3I4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14900"/>
    <dbReference type="EnsemblBacteria" id="AEB44092">
        <property type="protein sequence ID" value="AEB44092"/>
        <property type="gene ID" value="VAB18032_14900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14900"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_4_0_11"/>
    <dbReference type="OMA" id="GLMPQFI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="533" mass="53587" checksum="8EC4683EEA0A53F3" modified="2011-06-28" version="1">MSLPVHPPAPQPPATGGPAEPASDSTATETRRGARSGAAGLLGAAVNGLMGFVLVVVITRGYGTEGSGVFFAAIGVVTVAAALCVLGAETGLIWSLPRRRLGPQGDAARMLPVALIPPLSTALVIATVGILAADPLARRLLDGAGVDGAALLRVSFAAVPVVVAMTLLFGVLRCVRPMRMYVAVQSVLLPTARPLLVGAAVLLAGGGLLAGMTGWVLPALLAAAVTLLLVVGPLGIGRGAGLRARRDEWRSFWRFSLPRAASAAIDSGAVWIGVLLTTVLAGAADAGIFGAVSRYILAGQLAMQGLRVAVSPQLSRLFGQDRPDAAAALHRQLTTWALVLSWPVYLLLAVFGAGFLELFGSGFAGGATAMTVLALAMLVNTGVGNVQSMLLMSGRSGLHLAATVAGLTVTVSLGLVLIPAHGATGAACAWAAGIVTENLIAVTCARIVVGQPLADMSMLRAALFTVGGVGAAAIVGVLVGGRGIVGLAVALAVLAVGCVGLLTLPRVRQGIRATMVQIRGGAPSVSPRPSKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Z6</accession>
    <name>F4F3Z6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_27846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735292.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27846"/>
    <dbReference type="EnsemblBacteria" id="AEB46642">
        <property type="protein sequence ID" value="AEB46642"/>
        <property type="gene ID" value="VAB18032_27846"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27846"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_4_11"/>
    <dbReference type="OMA" id="HRQLWVT"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="12750" checksum="37136FE1EAE2226A" modified="2011-06-28" version="1">MSLSILQTVRPGGVIEIAPRGEIDVDTAYEVKEAIAEVLAKGRPARIELNMRLVTFIDSVGISAMVAGFQTAEVSGVKLVVTEPSRFVHRQLWVTGLLGLFGAPEPYYAGAATPEVLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Z7</accession>
    <name>F4F3Z7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46643">
        <property type="protein sequence ID" value="AEB46643"/>
        <property type="gene ID" value="VAB18032_27851"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27851"/>
    <dbReference type="eggNOG" id="ENOG50326BE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3159098_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309075" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="48" mass="4869" checksum="15369AB9CB618E87" modified="2011-06-28" version="1">MLRRLATLAGVSALLTLVLACGFGGGGDDDDDDDDDFARAAVAVVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F457</accession>
    <name>F4F457_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycerol-1-phosphate dehydrogenase (NAD(P)(+))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_03940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03940"/>
    <dbReference type="EnsemblBacteria" id="AEB47870">
        <property type="protein sequence ID" value="AEB47870"/>
        <property type="gene ID" value="VAB18032_03940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03940"/>
    <dbReference type="eggNOG" id="COG0371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038362_0_0_11"/>
    <dbReference type="OMA" id="ALHGEQC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="76"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="335" mass="35111" checksum="4F0E62C459D98993" modified="2011-06-28" version="1">MTDLGALLADRRISGGGDVAVVVGPGQGEKIAEMCRPSLGSADIFTVSGGTVDSANELGDQLRRRHYDAVVGIGGGKTIDTAKYAATRYALPMVTVATSLANDGIASPVASLSHEGGKGSYGVHIPIAVLVDLDFVENGPDRQTQAGIGDAVSNLSACADWELAHQVRDEPIDGLALTLARTGAEALVNHPGKITDDAFLTTLAEALILGGISMSVCGSSRPASGGDHEISHAIDHLYPGTGSHGEQVGLGALFCTFLRGDLERFGQLARCLHRHGLSTRPSELGLTDEQFVEAVAFAPRTRPDRYTILEHLALSADDLRTRLGDYVDALREHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4J8</accession>
    <name>F4F4J8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_09190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09190"/>
    <dbReference type="EnsemblBacteria" id="AEB42956">
        <property type="protein sequence ID" value="AEB42956"/>
        <property type="gene ID" value="VAB18032_09190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09190"/>
    <dbReference type="eggNOG" id="COG1246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119519_0_0_11"/>
    <dbReference type="OMA" id="IQEFWVA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045039">
        <property type="entry name" value="NSI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43626">
        <property type="entry name" value="PTHR43626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="177" mass="19880" checksum="7F239DC03764AA2E" modified="2011-06-28" version="1">MTAEATQAVPDDIVIRRARTADVRAIRRLVDTYTDDRRLLSKATVTLYEDVQEFRVATRVGDGRVVGCGALHVMWEDLAEIRTVAVDPSCRGRRIGHRIVAELIDAARELGVARIFVLTFETSFFASFGFTEIDGAPVPHAVYEQLLRSYDEGVAEFLDLERVKPNTLGNTRMLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4N5</accession>
    <name>F4F4N5_MICM1</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_15325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15325"/>
    <dbReference type="EnsemblBacteria" id="AEB44177">
        <property type="protein sequence ID" value="AEB44177"/>
        <property type="gene ID" value="VAB18032_15325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15325"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_6_3_11"/>
    <dbReference type="OMA" id="LRGYLVI"/>
    <dbReference type="OrthoDB" id="416257at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="408" mass="42745" checksum="4C53CB267EA5D75D" modified="2011-06-28" version="1">MKKLLAATLGILSAVGGFVDIGDLVAAGQAGARFGMAHSWVLLLGVIAICAYAEMAGRIAAVTGRAVFDLVRERLGARMALVNLMASYVVTVITLAAELGGVALALQLASGVPYLLWVPVAGAAVWLVLWRVRFPVMERLFGLAGLTLVVFAVALFWLPTDWAALGRGTVSIDDGGQGWGAYWFVAVALFASTVSPYEVFFFSSGGVEERWSAADLADARFSVLVGFPIGGFLALSLIATATVVLRPAGLTVSDLGDVAHPIVLAFGGVGLAIAALAFFAVTFGAALETGLSAAYAAAQYFGWQWGKRVSPREAARFHTVLLVSVLLGVLLLLTRIDPVTLTEYMLIISAVALPLTYLPILVVANDRTYLGDRVNGRWLNALGAVLLLIIVAAAIAAIPVAIGTRMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4W6</accession>
    <name>F4F4W6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylmuramoyl-L-alanine amidase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_21775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734108.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21775"/>
    <dbReference type="EnsemblBacteria" id="AEB45455">
        <property type="protein sequence ID" value="AEB45455"/>
        <property type="gene ID" value="VAB18032_21775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21775"/>
    <dbReference type="eggNOG" id="COG5479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044057_0_0_11"/>
    <dbReference type="OMA" id="ECPGNAF"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312688" evidence="3">
        <location>
            <begin position="32"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="4">
        <location>
            <begin position="163"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="369" mass="38768" checksum="54EC9144AF445415" modified="2011-06-28" version="1">MVTRRNALAAGAFAAAALPLTAVMTRGSASAESTPTGGQTAPRTLSRRAGRVRAGARVSGTSFPVSHLGVRWASDNPLRIRFRTTSGWASWQMVNGCDGGHDDAEVGGHAALISAPLATSYELDAGSADAVQIIELNTVDGPRDLRLAGARRGMPIGDRVVPVRYLSRAAWGADESLRFNPDGTPKFGADQFFPVQTVTVHHTAGQNDDPDPAGFVRGLYQFDLDRYGDLGYHLMIDEAGTVYEGRASGSDSQPMFGPAGADGRPLMISAAHVGGMNSGNLGIALLGDFTSRQPTAAARSALTKVLAGICAVQRLDPRAATTFVNPVSGAQLAVDTISGHRDWMATECPGNAFYPKLPALRKKVASLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4X3</accession>
    <name>F4F4X3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_21810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734115.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21810"/>
    <dbReference type="EnsemblBacteria" id="AEB45462">
        <property type="protein sequence ID" value="AEB45462"/>
        <property type="gene ID" value="VAB18032_21810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21810"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_4_0_11"/>
    <dbReference type="OMA" id="QFFWSYF"/>
    <dbReference type="OrthoDB" id="1213908at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="141"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="37661" checksum="5E88C30E71574727" modified="2011-06-28" version="1">MTVTLSPRALMSLLVNGPKATDVLHTALDLGLLDALEAGPVRLDALATRFGVLPLRLYKFLDCIESLGLLTRDEPDDDIGATSYRAVPGLRDAVNAVVGPDATERDRDRYPWRQLHGRLAESLRGEVSIDDGFAWPPKTAEQTAEFERSMALGLGPAIETVRRHSDRLWSDRHRLLDVGGGDGTLAAHILDTAPDLRADVYNLPAVAPLVAATRDARGHADRLGFVGGDFFVEPLPRGYDALSFVRVLHDWPNAVARELVQQAYAALDPGGLILICEEFRTPDRLAMQFFWSYFLIGVDSSVSRLREADFYTKLLTEVGFQDVAVLPGTWELVIAYKPSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Y6</accession>
    <name>F4F4Y6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734128.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21875"/>
    <dbReference type="EnsemblBacteria" id="AEB45475">
        <property type="protein sequence ID" value="AEB45475"/>
        <property type="gene ID" value="VAB18032_21875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21875"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111226_4_0_11"/>
    <dbReference type="OMA" id="VVGHVMW"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="160" mass="17904" checksum="2EB4751CD575514D" modified="2011-06-28" version="1">MACCIRRGEPTQPVDDDNWRAVADVVPRDDQRDFVAPSAARYLLLSLREGMWHSLAVCADDEVVGHVMWGWDDDDQSYWIGGMVIDASRQGAGLGRATVLTLVRWLMERPDCQGVRLSVHTSNDLARGLYGSIGFQELKPDEDGEIVAELTRQRFADRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5C1</accession>
    <name>F4F5C1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04435"/>
    <dbReference type="EnsemblBacteria" id="AEB47969">
        <property type="protein sequence ID" value="AEB47969"/>
        <property type="gene ID" value="VAB18032_04435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04435"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_8_0_11"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="30957" checksum="21FF641CDCE1CED4" modified="2011-06-28" version="1">MEAMRAVQILNPSGEVTMPRPERTRVMCVANQKGGVGKTTTTVNLAVALALHGNRVLVVDLDPQGNASTGLNVPHHTGVPDVYDCLINSVPLEEVAQAVEGIPNLWCVPATIDLAGAEIELVSVVARESRLARAIAAYPGHFDYVFIDCPPSLGLLTVNALVAAQEVLIPIQCEYYALEGLNQLINNINLVRQHLNPRLEVSTILLTMYDRRTRLADAVEQDVRNHFGDKVLQAVIPRNVRVSEAPSYGQSVMTYDPGSRGATSYFEAAQEIAERGVKEPVSRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5G1</accession>
    <name>F4F5G1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_09375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09375"/>
    <dbReference type="EnsemblBacteria" id="AEB42993">
        <property type="protein sequence ID" value="AEB42993"/>
        <property type="gene ID" value="VAB18032_09375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09375"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_11"/>
    <dbReference type="OMA" id="RHPRRGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="424"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="572"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="842" mass="89401" checksum="643D6081630B2148" modified="2011-06-28" version="1">MTSGRAGHSIDRPEGRGTPLGLHLLTAAVLCTALVAAVVGLSLPARLPVDDPLGGPARFGIAVAAFALSQLARLRFRAAAGVVSVTWAEAALIVCLYLVPPGWLPAAAMLGVALAWTAMTIVDEGRTTWEVARIAGAQTAAVALAVAVTTAIGQPLLAPLTPALALAVTAGAVTYLLAGAALGGFMLSVRHGMSIGRPLLAALRGKLLMFVGNLVVGVLVVVLIEIDLRWLLLLPVLLWLLQQTYRQRLRDDRERRTWRSFAEATAALNQLDERGVAVAGVTGALALFEAEIVDVEVARADGRWWRYRGDPGGRLVDREIPPPRDVTESEELVRDLSVGDTRVGRLRVRLPRTAPSTGRERDALAAYADALAAALHDAATHRELRLVTARSSYEAVHDPLTGLVNRAALLSQGDQALRQLAHDHPVALLLLDVDQFKEVNDTLGHAAGDQLLRLTANRLTALTRPGDLLARLGGDEFALLLTSVPVLGDHTAALAYALRQAREVAERLAAPAEVAGVRMSVEVSVGVVVAAAGTADLTELLRRADIAMYQAKSGGDSVATYDSTRDAASTDQLALLAELREALQTDDQLVLVLQPAVDLATGAPTGVEALIRWRHPRRGLLSPADFIRAVENSDQLGSFTRYVLDKALTVAAGWAGEGLDIPISVNLSARSLLDPRLPSEIAEALCRHQVPADRLVLEITETVVMSELEVIDQVLSALRAMGVQLAVDDFGTGFSSLSFLARVAVDELKVDRSFVLRMGDSPQAAAIVRYTVGMAHELGLRVVAEGVETAAQRSALTELGCTAAQGYHFFKPMPADKIAAVLNSLARQTPTNVLPLRADGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5I4</accession>
    <name>F4F5I4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosylphosphatidylinositol specific phospholipase d1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09490"/>
    <dbReference type="EnsemblBacteria" id="AEB43016">
        <property type="protein sequence ID" value="AEB43016"/>
        <property type="gene ID" value="VAB18032_09490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09490"/>
    <dbReference type="eggNOG" id="ENOG5034717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2142983_0_0_11"/>
    <dbReference type="OMA" id="VQDGTFH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="110" mass="11661" checksum="446136A9BF340A89" modified="2011-06-28" version="1">MHAYGPTGSGTVLLNLGGDTGALIIYTGRQLLGREIEISPLGEDGRPRTHAAVRERPVQDGTFHSAVYPDLPAGSYTIWWDEKRPAGTVAVTGGGVAEFVWPTSDSPPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5J2</accession>
    <name>F4F5J2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, asnc family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_09530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731695.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09530"/>
    <dbReference type="EnsemblBacteria" id="AEB43024">
        <property type="protein sequence ID" value="AEB43024"/>
        <property type="gene ID" value="VAB18032_09530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09530"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_2_11"/>
    <dbReference type="OMA" id="TYMWGTR"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="172" mass="18976" checksum="49440F26C2B85CD7" modified="2011-06-28" version="1">MTNRQHDNGNGNGGRRVSVREGASHALLDDVAKQIIEQLQQDGRRPYATIGKAVGLSEAAVRQRVQRLLDAGVMQIVAVTDPLQLGFPRQAMIGLRTDGDLESVADRIAEFDEVDYVVITAGSFDLLAEVVCRNDEHLLEILQRLRAVTGVVSTEAFVYLKLRKQTYTWGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5J7</accession>
    <name>F4F5J7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731700.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09555"/>
    <dbReference type="EnsemblBacteria" id="AEB43029">
        <property type="protein sequence ID" value="AEB43029"/>
        <property type="gene ID" value="VAB18032_09555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09555"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_3_2_11"/>
    <dbReference type="OMA" id="YHAGQCL"/>
    <dbReference type="OrthoDB" id="1087129at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="39"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="472" mass="51220" checksum="C17F16C1BE88B388" modified="2011-06-28" version="1">MNLPPPGRALTDAVRAPYWLDRPERPDPVPPLAGPTSADLLVIGGGYGGLWAALLAKQADPGRDVLLVEAGSCGWAASGRNGGFCAASLTHGLANGVQRFPDEIDELERLGRENLDAIAATVAAYGIDCDFERTGELAVAVEPYQLDGLAEDVALARRYGHDVSLLDADEVRAEVDSPTYLGGLWDRDRVAMLDPARLVWGLRRACLDLGVRIHEHTRVTGLRRAGAALLAETTGADGVPGAVRADRVVLATNAFPPLLRRLRAWVVPVYDYALMTEPLTPAQRDAIGWRNRQGLADTGNQFHYYRITGDGRILFGGYDAVYHYGNRMAPALEQRDATFTALATHFFTTFPQLADLRFSHRWGGVIDTCTRFCAFFGTAYDGRLAYAGGYTGLGVGATRFGARVLLDLVAGADTPLTRLALVRDKPLPFPPEPARAVGIGFTRWSLARADAHEGRRNLWLRTLDRVGLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5P0</accession>
    <name>F4F5P0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44253">
        <property type="protein sequence ID" value="AEB44253"/>
        <property type="gene ID" value="VAB18032_15705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15705"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2792878_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="68" mass="7453" checksum="00E6FA2CD72EF6EA" modified="2011-06-28" version="1">MATLIKEEADTKSAAAQLGHSSEEVTTTYYIAKPVQAPDVSDVLERLAAHPNRQHTSPTPNDAHRRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5R1</accession>
    <name>F4F5R1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732938.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15820"/>
    <dbReference type="EnsemblBacteria" id="AEB44274">
        <property type="protein sequence ID" value="AEB44274"/>
        <property type="gene ID" value="VAB18032_15820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15820"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056518_0_0_11"/>
    <dbReference type="OMA" id="RMITTNA"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="36"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="32615" checksum="D85EB1B7C9D4A9F1" modified="2011-06-28" version="1">MFVEARTRPVLAEVCRLLGYPDSNAILLRHHTNAVYAVGDVVVKIAPGDQDLEQVHAMVAVVDWLVAQDFPTVRLHPGLSQPVLAGGHAVTVWQRLDPAHDNPITVSELGTLLRDLHALPAPPVPLPVLRPIHSIERSVARSEILNDKEQDLLMGRLETLATGWETMRFPRGASLIQSDPQVRNALRRFDGRPVLSDWDGAALGPREWDIATIAVHCRRFDPPGPGAFADFTAAYGWDATSWPQFEELCQLRELQMIATNARKSRPGTEAADEVHHRIAGLVDDGADLRRWHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5T9</accession>
    <name>F4F5T9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732966.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44302">
        <property type="protein sequence ID" value="AEB44302"/>
        <property type="gene ID" value="VAB18032_15960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15960"/>
    <dbReference type="eggNOG" id="ENOG503032E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1577830_0_0_11"/>
    <dbReference type="OMA" id="PITVWPV"/>
    <dbReference type="OrthoDB" id="1649659at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="169" mass="18078" checksum="F5D6828AB547F388" modified="2011-06-28" version="1">MSGDPPVPITVWPVPAPPDGETMSNAMAVRLVHNLTHPTDLVIDLVVGPQLARAVIAAHRRSHLHHRHPGWGREPAMLVVTGWPVDDTPPGEFFARCRAGLLPGGCVAVLLPHGDLVLPVDVVIAAKRAGLAYLQHIVAADRPPRPGQRTQLDIHTDVLILTRRGGADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F691</accession>
    <name>F4F691_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_28861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735492.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28861"/>
    <dbReference type="EnsemblBacteria" id="AEB46843">
        <property type="protein sequence ID" value="AEB46843"/>
        <property type="gene ID" value="VAB18032_28861"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28861"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_11"/>
    <dbReference type="OMA" id="RDPWSVN"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="32"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="360" mass="37829" checksum="17E0B0D8DFCA723D" modified="2011-06-28" version="1">MHAPLTPATRSTAEPDLTHHGDAEVGAGLVDLAVNVRRAPMPDWLAEPITASLADLAGYPDPEPARAAVAARHGRPPAEVLLTAGAAEGFVLLAQALRGIRRPVVVHPQFTEPEAALRAAGHQVQRALLDPADDFRLHPDAIPADADLVMIGNPTNPTSVLHPAADLATLARPGRVLVVDEAFADATAAPGHPGEPESLAARRDLPGLVVVRSLTKTWGLAGLRIGYLLGEAELLHRLAAVQPLWAVSTPALAAATACAGPTAVQAERAIAAQLAADRDHLVTRLSALPGVRVVGRPASAFVLIHRPGADRIRAALREHGWAVRRGDTFPGLGPDWLRIAVRDRACTDVFIKVLAEILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6D3</accession>
    <name>F4F6D3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_09805</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731750.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09805"/>
    <dbReference type="EnsemblBacteria" id="AEB43079">
        <property type="protein sequence ID" value="AEB43079"/>
        <property type="gene ID" value="VAB18032_09805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09805"/>
    <dbReference type="eggNOG" id="COG2177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073546_1_0_11"/>
    <dbReference type="OMA" id="ETGIMRL"/>
    <dbReference type="OrthoDB" id="1653234at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="13">
        <location>
            <begin position="56"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="12">
        <location>
            <begin position="196"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB43079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="291" mass="31733" checksum="DF521E143BDF73B4" modified="2011-06-28" version="1">MRMKYVLSEVLVGLWRNVTMTIAMIITLGVSLTMLGASGLIYTKVADMKDLYFENIQVSIFLKTDISEEDRAALGSRLEADPLISQVTYVNKDEAFQRFQEMFRDSPDLLSAVKADQLPESYRLNLVDPEQYKSISEQYSSAAGVDQVVDQSQVLDKIFNLFTAGQNVALAAAIAMAVAALLLVANTIQVAAYSKRREVAVMKLVGASNWFIQAPFVLEAVVAGLIGSVLGLGALVALKKFLFDDALSALQGLFAPVSWSEVLLTFPVMAGVGGLISAVTAWVTLRFYLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6I9</accession>
    <name>F4F6I9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732979.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44317">
        <property type="protein sequence ID" value="AEB44317"/>
        <property type="gene ID" value="VAB18032_16055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16055"/>
    <dbReference type="eggNOG" id="ENOG5032MYX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1739737_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="16489" checksum="FDDE26A13430D945" modified="2011-06-28" version="1">MNVVEFDALVEPLRQKSVASLAEHGFALIEGRTATVAEVADLEKQLGVTLPETYKAFMMRYGGGVVGCVELFPIVSAGSGDDDVESVNDREFPDRTFIAIAPVGTGDYWGFPVDDGHCREEVWFHFHDGGDPEFEAADVLEFIVRHGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6N5</accession>
    <name>F4F6N5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16285"/>
    <dbReference type="EnsemblBacteria" id="AEB44363">
        <property type="protein sequence ID" value="AEB44363"/>
        <property type="gene ID" value="VAB18032_16285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16285"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_751903_0_0_11"/>
    <dbReference type="OMA" id="FCHPNTV"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="315"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="376" mass="39709" checksum="EAC7B892C0D5514B" modified="2011-06-28" version="1">MTHPDGWTTMVDLIERVVGDDELLPSVVAGVRTTVREVSALPTSDIAGHTRALLVAATRALAARRGPTEAELSFVADLGVTRARQGVPIESVLGAIHFAERAIWARARELARAQGVSAEQLLDVRDLYDDWAEAVRARLISAHRATGASTDPLPGRRDTALLRRLLQGGSAATLAAAEAGLPVTDGLWVLVARPGETAAGIERAVREHPPVLCATVDDLMVGVLSRAPSARLEGIGAVAGLAGPAEPEKLAPVRRLATAALTAAESTGRTGLVHIADVAWLAALTERADLATVLLDRYAPAWAALGPTAESVAHAVLAWLESDRDVDLAGANLFVHPNTVRNRVRRFAAVTGIDPAGTFGAMTAWWLCRTWLRDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6P2</accession>
    <name>F4F6P2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48, Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_16320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16320"/>
    <dbReference type="EnsemblBacteria" id="AEB44370">
        <property type="protein sequence ID" value="AEB44370"/>
        <property type="gene ID" value="VAB18032_16320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16320"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053828_0_0_11"/>
    <dbReference type="OMA" id="WCAACDW"/>
    <dbReference type="OrthoDB" id="1767187at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="162"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="448" mass="48645" checksum="747E2D794D8E7D2F" modified="2011-06-28" version="1">MHCCHFDLDSTLVPTKTTLSRCPACAHELVLLEAGAPSWCPACQWNLDVYDPALAPWRGTRMIGRWGFRRGLEIDRATYEQVLAAPEARPDGTSSGEVWLSVVSVLLALLGVAAVGYLAWLVVASDLPQGVRLALAIPAVLVLLLVKPSFGRVPRYGVITEREAPQLHRLVREVADAAGTPVPDVICADLSLNAGVARLGWRQRSVLVIGIPLWVMLPRPARVSLLAHELGHLANGDPLRVRRTLLARTFGARAVVATGGRNPWRRAVHAADSLAEQGSGPVVLLGMIVHGIVALANVAGATAQLLVDSVAMPDSRRAEYRADLVARRVAGSAAFLRSSETVLLAGRIWQDLWHLAPRIDGEQLEAAAAEARESLAARLPLARQLSRRTTDLWSSHPGEDQRMRLIEALPAVDGALCVDTRRWADIDTELAPRRRAAHNILLGTRDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6S4</accession>
    <name>F4F6S4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_22495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734251.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22495"/>
    <dbReference type="EnsemblBacteria" id="AEB45599">
        <property type="protein sequence ID" value="AEB45599"/>
        <property type="gene ID" value="VAB18032_22495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22495"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_2_2_11"/>
    <dbReference type="OMA" id="SIFVMQG"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017779">
        <property type="entry name" value="ABC_UrtB_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03409">
        <property type="entry name" value="urea_trans_UrtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="30818" checksum="996BEA02110E7F27" modified="2011-06-28" version="1">MTVLIGQLFTGVSIGAVLLLIALGLALTFGQMGVINMAHGEFIMAGAYTTFVLQQVITAAGWSLLIALPVAFVVAGAMGVLLEFLLIRRLYARPLDTLLVTWGVSLILQQLARDIFGSPNVQTRAPELLTGNIALPGGITVANNRLFILALAGGAVVALTVALRITPLGRRIRAVVQNRDLAAVSGIATARVDRMTFFIGSGLAGIAGVALTLLGPIGPTMGTNLIIDAFLVVVVGGIGQLKGTVIVAFALGVLQATGEYLTTLSVAKVMVFVAIVAFLQWRPQGMFTLRTRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Y6</accession>
    <name>F4F6Y6_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734313.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22805"/>
    <dbReference type="EnsemblBacteria" id="AEB45661">
        <property type="protein sequence ID" value="AEB45661"/>
        <property type="gene ID" value="VAB18032_22805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22805"/>
    <dbReference type="eggNOG" id="COG2456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134280_1_1_11"/>
    <dbReference type="OMA" id="KYAALWL"/>
    <dbReference type="OrthoDB" id="2086586at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019277">
        <property type="entry name" value="DUF2304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10066">
        <property type="entry name" value="DUF2304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="14030" checksum="6BB583C05C9CF16A" modified="2011-06-28" version="1">MKLTLVTGLTGLVLLATIVELLRRRQLREKYGMLWLGLLFVVIPLSLFPRLLDGVADLVGVASGVSLVLFLGIVFLLLVCIHLSWEVSALEEETRTLAEEFALLRAEVEADRAERADRQELVSRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Z2</accession>
    <name>F4F6Z2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28926"/>
    <dbReference type="EnsemblBacteria" id="AEB46856">
        <property type="protein sequence ID" value="AEB46856"/>
        <property type="gene ID" value="VAB18032_28926"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28926"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051796_0_0_11"/>
    <dbReference type="OMA" id="HGFVDYF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="56"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="365" mass="40253" checksum="D311786FBADEC8D4" modified="2011-06-28" version="1">MRAGRGYHPVGGRRTVGTVEPDLLGPPYERHTIDLGSDDEGPVVATLVRRRAERPSRRAVLYVHGFVDYFFQTHVADFFAAQGWDFYALDLRKYGRSLLPHQTPNFCCDLGDYFPELDAAAEIIRTEDGHDTVLAMGHSTGGLIVSLWAHDRRDAGLVDGIVLNSPFFDLNAPWLVRRPLAAAVARLGRRAPQRILPFSLGTVYGESLHADHRGEWTYDLAWKPLAGFPVRAGWVDAIRTGQRRLRAGLDIQVPVLLACSTRSFRSTKWHESATLADAVLDVEHMVRWAPRLGPHITLARFDGGLHDLTLSGPAVREKVFAEVGRWADAFLGAGPTPTDPPVPDPRPAPSGNRKADDPEQADATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Z8</accession>
    <name>F4F6Z8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735511.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28956"/>
    <dbReference type="EnsemblBacteria" id="AEB46862">
        <property type="protein sequence ID" value="AEB46862"/>
        <property type="gene ID" value="VAB18032_28956"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28956"/>
    <dbReference type="eggNOG" id="ENOG502ZR8P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171888_1_0_11"/>
    <dbReference type="OMA" id="HSPEFGP"/>
    <dbReference type="OrthoDB" id="2065808at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046251">
        <property type="entry name" value="DUF6284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19801">
        <property type="entry name" value="DUF6284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="80" mass="8819" checksum="8F84755827465FFB" modified="2011-06-28" version="1">MTESNHSPEFGPSAAELAEIEQELPLIEAEVLLLDAQIVVLTGDSGPTELDWQRLRRAQRRVLREARALLAVRSAADRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7D1</accession>
    <name>F4F7D1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731860.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10355"/>
    <dbReference type="EnsemblBacteria" id="AEB43189">
        <property type="protein sequence ID" value="AEB43189"/>
        <property type="gene ID" value="VAB18032_10355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10355"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_530824_0_0_11"/>
    <dbReference type="OMA" id="LATAQCD"/>
    <dbReference type="OrthoDB" id="1320038at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="485" mass="50739" checksum="4FA2308653B46670" modified="2011-06-28" version="1">MKPGPLHHLGTTDGTPGLSGTGPFPERLGVSATSPREPLAVIAVGPAGAGRTEVLAALLELDAGMLTTLAGSWLVVRHALQPSRAAFVPGYRQPHSYRVDLPTVGPALARPPRRVELNLPEPLLKHFALVDTPDTGTMGPAGGQILLDAVGRAGALLFVIAADQSFSSAELNLLAEIAGTPVQVFFAVTPGTGNPTIDPAAVDACRAALLAAVPGLADARWFPIINGDAADLKRAMVAWAADEGLCRASGEPPELPGTHGRVPVVAEPGAWSEQLDRQSRAAAQRIRQCLALELARVHLRVVQDILFGGGCAGLPQLVDREMEALSLLATAQCDHAVRVLVDDIAGRLFGGPLAAGVRQRIYQAVAWSMPEHTPGPELERVLLITSTAGVAGLSGAAAIDALSTYPGPARSEVLPPVAVALSGGCWQHWRTPANNDPDAARAWAQRALREIELELSREVARRFEAIRISLGTVLSDAAEHGILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7F0</accession>
    <name>F4F7F0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EmrB/QacA drug resistance transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">EmrB/QacA family drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">abyD</name>
        <name evidence="7" type="ordered locus">VAB18032_16415</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733049.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16415"/>
    <dbReference type="EnsemblBacteria" id="AEB44389">
        <property type="protein sequence ID" value="AEB44389"/>
        <property type="gene ID" value="VAB18032_16415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16415"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_11"/>
    <dbReference type="OMA" id="IWVPNAY"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEK75506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="475" mass="48825" checksum="8DABDB6FB9C444CE" modified="2011-06-28" version="1">MTQSPSDRIDGPLLRLLGVMVLGGVMSYFDATIINVSVETLTAHFDATLGTISWVATGYLLAVAVAIPLAGWAVARFGARRVWLAALTLFLVASALCALAWDVGSLIAFRVFQGFAGGLLEPIMLTVVATAAGPSRMGRAMGLISIPITLGPVLGPIIGGLILQNLTWQWIFLVNVPIALLAIALALLIMRDDRPEPGAAPPLDLIGVALLSPGFAALIYALSQAGTAGFGATRVIVGLAVGVVLVAAYVAHALRSAQPLIDLRLFRSSGFTSSVLTMFLLGGMLFSLLFLLPLFYQQVRGQGVLAAGLLLVPLGLGTMVGMPVAGKLADTFGPRRLVPTGALLIALSALVYTQAGPDTSQVLLTAAQLVTGFGLGLVGAPTMGSVYRTVAPEAVGGATGTLFILNQIGASLGVAVVALIVQSGLTDGRTPADSFDQAFWWTVAGGVIVALASRFLPGRPQPVTPTPADAETAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7L6</accession>
    <name>F4F7L6_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44455">
        <property type="protein sequence ID" value="AEB44455"/>
        <property type="gene ID" value="VAB18032_16755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16755"/>
    <dbReference type="eggNOG" id="ENOG5033HWY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177682_0_0_11"/>
    <dbReference type="OMA" id="RWATRAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="94" mass="10782" checksum="36054FC512F8E30A" modified="2011-06-28" version="1">MSLSHHPPPNRDQIESMLLALLDGGQSRDEVDRWAAQWVTDPDGGGVEDADVWWALTQLHGIDLRYAKDGPYLHDEEQIRHWLHAFRACRPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7N2</accession>
    <name>F4F7N2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22845"/>
    <dbReference type="EnsemblBacteria" id="AEB45669">
        <property type="protein sequence ID" value="AEB45669"/>
        <property type="gene ID" value="VAB18032_22845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22845"/>
    <dbReference type="eggNOG" id="ENOG5033IEX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417343_0_0_11"/>
    <dbReference type="OMA" id="ANICVST"/>
    <dbReference type="OrthoDB" id="213184at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="657" mass="70375" checksum="15888C80B2A57524" modified="2011-06-28" version="1">MPAEQHTVAPLIVPSLTASPGKPYRRWNLAVLAALPAAWLLPLAAVALDARWVLPPLVLLATASLLRGGRTLLDRLLLATILLVCLTTAAGLLFAVWPWGMNPVAVSGTALTALVLTALITGRRPTLPRPAWPDLLPVIGTTGLLWYLAQPLLRAGDLGGRLSILHRGEDYLRHLSLVDVIGRHGGYLFVDPAAVRDDLFSALVHYPQGWHLLVALLDSHRTPPGGGPAGAAAVEPFLWWNFATFGLLVLVLLWAAQRLPGPLHPLSRLVLTVVVGALVLGSQMPRMLVSGYPTETLGLTLTIVLAVLVARPVGAPREHFLLLGALLVGIGYSYYLFLPAAALLALGSLLARRREVRRLRGTTLVVGLATAVLAPVPILLGVFRANQTESLAATVGPDLTETWLALGGLGVFVVPALLVHAVRRGRADPAWRRWLFALLVSVVLTLAIGQASISVGGQAGYYFNKAGHLTTVLLIIGTAAVVRLLPVPPRGRPLRTAVAGLTAVTVAAATVWFAGVTGGQRSLLVVTPQSWAQRWVHQDLDRPGRATAVCEQVLQRYPAADGVTTLILDRRPYQSYLANICVSTLQGTTAQTEAGIYEMVFVEPGRTWQMLHRVPGEIRLVAVTDGARVRTNRILRAVPELAARVSMETMIIDDPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7R7</accession>
    <name>F4F7R7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734356.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23020"/>
    <dbReference type="EnsemblBacteria" id="AEB45704">
        <property type="protein sequence ID" value="AEB45704"/>
        <property type="gene ID" value="VAB18032_23020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23020"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_2_11"/>
    <dbReference type="OMA" id="NYGDHSG"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="202"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="442" mass="47920" checksum="E0866A11271AC9D1" modified="2011-06-28" version="1">MTSDAHPALPAPTDEVVDLCRDLLRIDTTNTGDNATSTGERLAAEYVAEKLAEVGVESVLHESAPGRANVIARIPGTDPSRGALLVHGHLDVVPADPDEWSVHPFSGELRDGYLWGRGAIDMKDFDAMVLAVVRHWQRTGVRPPRDIVLAYTADEEAGSDYGAHFLASRHRELFDGCTEAIGEVGGFSYTVDESRRLYLIETAEKGIDWLRLHAKGRPGHGSMVHDDNAVTALAEAVARIGRHRFPVVVTDTVRAFLEEVSELLGIELDPEDPETAIAKLGPIANIIGATIRNTANPTRLAAGYKENVIPGSASATIDCRSLPGQSELLERQLRELIGPDIAIEYIQRQPALETTFDGDLVEAMSAALRAEDPGAHPVPYMLSGGTDAKAFSQLGIRCFGFAPLRLPADLNFSALFHGIDERVPVDGLQFGVRVLDRFLRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7T9</accession>
    <name>F4F7T9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23130"/>
    <dbReference type="EnsemblBacteria" id="AEB45726">
        <property type="protein sequence ID" value="AEB45726"/>
        <property type="gene ID" value="VAB18032_23130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23130"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_6_0_11"/>
    <dbReference type="OMA" id="MLEFWVD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="17190" checksum="E1AFFB6B9DE060C9" modified="2011-06-28" version="1">MMPQTDPAAHCQVPPPGSRGIDEILSAARARLDRLDPEQAHLAYRAGALLVDIRPAAQRAAHGTVPGALAVERNVLEWRFDPRCPARLPQAVGYDLPVVVLCQEGYTSSLAAASLQDLGLFRATDVIGGFAAWRIAGLPVLGPTPPIRPSTPAPPATAGRVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F807</accession>
    <name>F4F807_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735630.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29556"/>
    <dbReference type="EnsemblBacteria" id="AEB46982">
        <property type="protein sequence ID" value="AEB46982"/>
        <property type="gene ID" value="VAB18032_29556"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29556"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033707_1_1_11"/>
    <dbReference type="OMA" id="HVMARLG"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="56"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="33042" checksum="285B4AE04A1B1F8D" modified="2011-06-28" version="1">MSTDRELTFHSAGHRLVGTLTLPDGPGPHPTALLLPGSGPLNRDGDHRRMRIGIQRDLAAALAAAGIATLRYDRRGIGESSGGFWPTGFHDNVDDAQAALAALDADASVDSRALFLVGHSEGALTATTLAARGVTTAGLVLLSSSARLGAEVLRWQTAQILPTLPAPVRLLLRLMRLNLVARVSRNHEKILATTADVTRIGGQRINAKWMREFLRYDPRPDLARINAPILAVTGSKDLQVDPADLTLIAEHAGGPVQTRLLPDVTHVLRHQPGPPSLGAYRREIRNPVDPAVTGAVVDWLRARVVELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9D7</accession>
    <name>F4F9D7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionine synthase vitamin-b12 independent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11065"/>
    <dbReference type="EnsemblBacteria" id="AEB43331">
        <property type="protein sequence ID" value="AEB43331"/>
        <property type="gene ID" value="VAB18032_11065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11065"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065357_0_0_11"/>
    <dbReference type="OMA" id="DRPGRDT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="346" mass="35411" checksum="7A94A2A8412EEDED" modified="2011-06-28" version="1">MGAATGIGSLPGSDIAEAQRIVLGELPALPHVPELPARGPGADLIGRTAGLLVELPVELYAARWRVAPRPGKDLRRARDLMERDLDQLAEQAEEYAGTIKIQAGGPLTLAASLELPIGGRMLRDPGAVRDLAGSLAEGLRGHVEAVARRLPRASVLLQLDEPSLPTVLAGRVPTESGLGTYRAVESETARALLRGVIEAAGVPTVVHCCASDVPLELIRSAGAVGVALDLSRVTELDPLGEALDAGLGLLAGAVPTSPPPGGEPTPGGQPTPRGRPGTAPPAGGAPTSAQVADRVRGLWDRLGFPRAQLAEQVVVTPACGLAGATPAYARAVLAACRDAGRRLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9H4</accession>
    <name>F4F9H4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44552">
        <property type="protein sequence ID" value="AEB44552"/>
        <property type="gene ID" value="VAB18032_17250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17250"/>
    <dbReference type="eggNOG" id="ENOG5031VJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149128_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="14392" checksum="4F1C63BCB2470300" modified="2011-06-28" version="1">MLDLLGRDLALTLEPAKIAVPSGARVEIDGCDSGRTVLVECWAHQGPPKSAQRHKVLADALKLTWIASTMYPRPRLVLCMSDPAAARPFQPTSRTWAAQALLDLAITVHVVEIPDDIRQKVRAAQERQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9J6</accession>
    <name>F4F9J6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma-24 subunit, ecf subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_17360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733229.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17360"/>
    <dbReference type="EnsemblBacteria" id="AEB44574">
        <property type="protein sequence ID" value="AEB44574"/>
        <property type="gene ID" value="VAB18032_17360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17360"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OMA" id="MYREQVS"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="170" mass="19467" checksum="2ACE833B3A9D53C6" modified="2011-06-28" version="1">MDDKARARFGEFAQNRTAALIRAAYLLTGDQHAAEDLVQSALAKTYARWPTIRHEDPEGYVRAVMYRERVSWWRRRGRLRETLVGSPVEREHPDDSGHADLRLAMRAALLRLPVAQRAVLVLRYYEDLPEQQVAEVLGCSVGTVRSRTHRAVSRLREVLPGAELVLELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9U0</accession>
    <name>F4F9U0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein, LacI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_23840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734518.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23840"/>
    <dbReference type="EnsemblBacteria" id="AEB45866">
        <property type="protein sequence ID" value="AEB45866"/>
        <property type="gene ID" value="VAB18032_23840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23840"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="MISGSRW"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="34060" checksum="56D1AB30C671ED79" modified="2011-06-28" version="1">MTTVRRHATLEDVARAAGVSRSTASRVLAESGFASPIARERVRDAADRLGYVPNAAARALVRGAGVRLLVAVAGTSPTVLDDSYLDQVVSTTAQVCAPYGLGVTVAWVPLDQPGQLARLADDRAVAGLVLVNTTEALLDVVPRRLYGRTASIGIGSTAVPSVDIDNGGGTSAIVRHLYAAGRRRIAMVTGPAWLACSRRSVEAYRGLLREAGLPVREVAGDFSAARGRSAAREVLHRWPDTDAIVGISDATALGVIDQLRADGVRVPADVAVTGFDDIPLASVTALTTASHPVRRIAAAAATMVLEERTAPPMTMFPSSLVLRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9U6</accession>
    <name>F4F9U6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734524.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23870"/>
    <dbReference type="EnsemblBacteria" id="AEB45872">
        <property type="protein sequence ID" value="AEB45872"/>
        <property type="gene ID" value="VAB18032_23870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23870"/>
    <dbReference type="eggNOG" id="ENOG50328BU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101335_2_0_11"/>
    <dbReference type="OMA" id="ECEGWER"/>
    <dbReference type="OrthoDB" id="1735899at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="159" mass="17361" checksum="326107AE347D9288" modified="2011-06-28" version="1">MPTTATPQPGAPVDPYRAYNFKLLVNGVTNGHFTEVSGLEVNIPAVAYREQGNDRIRMIPGQVEYGPVTLHFGLTSSRELWDWVHAVARGTVNRRNVSVVLLDAAGTAEVLRWNLINAWPTNWRGAHLNTLSQEIAIAALTLRYESLELEAGGAAPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA15</accession>
    <name>F4FA15_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735772.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00210"/>
    <dbReference type="EnsemblBacteria" id="AEB47126">
        <property type="protein sequence ID" value="AEB47126"/>
        <property type="gene ID" value="VAB18032_00210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00210"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_0_3_11"/>
    <dbReference type="OMA" id="FEIQDGH"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="67" mass="7288" checksum="459D5D86688E8F05" modified="2011-06-28" version="1">MAIGTVKWFNADKGFGFITPDGGGADVFAHFSAIQSSGYRSLDENQRVEFEVVQGQKGPQAENIRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAY5</accession>
    <name>F4FAY5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734600.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24250"/>
    <dbReference type="EnsemblBacteria" id="AEB45948">
        <property type="protein sequence ID" value="AEB45948"/>
        <property type="gene ID" value="VAB18032_24250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24250"/>
    <dbReference type="eggNOG" id="COG3502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129452_0_0_11"/>
    <dbReference type="OMA" id="QDGFIHF"/>
    <dbReference type="OrthoDB" id="1997747at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="PTHR34129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="111" mass="12021" checksum="00A0E148ECCC7C44" modified="2011-06-28" version="1">MLIYKILLPGEWAQFQAAGRFDGSPFDRDSGFIHCSSRAHLPATANRFFGEQPQLVVVALDADWFGDTLRWEEASDGGVFPHVYGVLPADAVTGVHHVAGAARIDEDVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB27</accession>
    <name>F4FB27_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735817.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00440"/>
    <dbReference type="EnsemblBacteria" id="AEB47172">
        <property type="protein sequence ID" value="AEB47172"/>
        <property type="gene ID" value="VAB18032_00440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00440"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933101_0_0_11"/>
    <dbReference type="OMA" id="IHNIGYR"/>
    <dbReference type="OrthoDB" id="2042171at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="293" mass="30779" checksum="C93B329B4A962B1A" modified="2011-06-28" version="1">MSEPTGVIHDIGYQRYTGLRLGRRAVFGALYVHGVRTAFGLGRSAKAKIFPWLVVGIVLMVAGAVTAIGSQIGETLMTYAQFADSMSWLVIFFVAVAAPELVSRDLRSGVLPLYFSRPLPTADYPMAKLLALATALWMLLGAPQLVMFLGAAFTGNDMGAVWDELLDLVPGLLYAGLWAVVFASVGLLIASLTGKRAFAAGGIVAVFLMTTPIVGVLSILPAQAANQLAGIASPSTLVQGVGIWTMRDQVITDPDALGPDLGAFGPVYALVAALLVAACVALLLARYRKVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB59</accession>
    <name>F4FB59_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735849.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00600"/>
    <dbReference type="EnsemblBacteria" id="AEB47204">
        <property type="protein sequence ID" value="AEB47204"/>
        <property type="gene ID" value="VAB18032_00600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00600"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="EPLRTYY"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="336" mass="37179" checksum="9B515C58C7C5CA2B" modified="2011-06-28" version="1">MSDYVLETRDLVKHFPLTQGIVFKKQIGAVRAVDGVNLQLRRGETLGVVGESGCGKSTLARMLVGLETPTSGDLFVQGRNMAKVGAEERRRGRRNIQLVMQDPYTSLNPRMTVGDIIGEPFEVHPDVVPKGQRRGKVQELLELVGLNPDHINRYPHQFSGGQRQRIGIARALALNPEIILCDEPVSALDVSIQAQVINLLEKLQNELGLSYIFIAHDLSVVRHIADRVAVMYLGKIVEIGTEDEIYETPTHPYTQALLSAVPVPDPTLRGQRDQIVLTGDVPSPANPPSGCRFRTRCWKAQDICAEQEPLLEVRDKSGHPSACHFAEVRDVVHATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB95</accession>
    <name>F4FB95_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735885.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47240">
        <property type="protein sequence ID" value="AEB47240"/>
        <property type="gene ID" value="VAB18032_00780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00780"/>
    <dbReference type="eggNOG" id="ENOG5031UV0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2095861_0_0_11"/>
    <dbReference type="OrthoDB" id="1625306at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312868" evidence="1">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="116" mass="12199" checksum="5E7902777CC42549" modified="2011-06-28" version="1">MRPSKSVRTALLATIGAAAIAVTGAPAAAAESRSCTYVDGTLCLHESKWFNGATVEYPAPFGADCVNSSMGFLGWLNLTDYSLRVYEGANCTGISYYVPSGDLHNVQAPLSSFKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBD9</accession>
    <name>F4FBD9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type ii secretion system f domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_05545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05545"/>
    <dbReference type="EnsemblBacteria" id="AEB42235">
        <property type="protein sequence ID" value="AEB42235"/>
        <property type="gene ID" value="VAB18032_05545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05545"/>
    <dbReference type="eggNOG" id="COG4965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068419_0_0_11"/>
    <dbReference type="OMA" id="HRTTIRW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="121"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="301" mass="31472" checksum="1186CCB3D111248D" modified="2011-06-28" version="1">MVLDNIELLAVVSGAACVAGLVLTVVALVGTRRPPGPAPGAGPGISRLWRGSGTTVREQQAHQALLIGAVVAGALAFLLTGLPVVGLLVAVAVPGTPWLFSVGRAEQRAIARIEAVGEWTRRLKDVSATGQGLQQAIIGTVGTAPEEIQDEVRLLAARLQAGWLARSALLAFADEIGDPVCDQVVAALILHLTDRGERLGDVLGSIASAAAAEVTTRREIEAKRTQPRFAVRFLTGMTLATIAYGLFNAEYVQPYGTPFGQLVMALLGAAFVGLLAWVRSMSQPPRPARFLPAPDPEEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBI7</accession>
    <name>F4FBI7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="9" type="ordered locus">VAB18032_11675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732118.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11675"/>
    <dbReference type="EnsemblBacteria" id="AEB43449">
        <property type="protein sequence ID" value="AEB43449"/>
        <property type="gene ID" value="VAB18032_11675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11675"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_11"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="27167" checksum="2C85CE0B7771C16B" modified="2011-06-28" version="1">MTQVVSDRTLAADDPTAPPPGRSRRVVLKLSGEVFGGGAIGVDPDVVQAIARQIATVVRRGVQVSVVVGGGNFFRGAELQKRGMDRARADYMGMLGTVMNCLALQDFLEKEGIETRVQSAITMAQVAEPYIPLRAIRHLEKGRVVIFGAGAGMPYFSTDTVAAQRALEIHADVVLMSKNGVDGVYTADPRIDPTASKFDSITFSEVLRRNLRVADAAAFSLCMENGLPMLVFGAQGDDTIVRAVGGDKIGTLITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBL3</accession>
    <name>F4FBL3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11805"/>
    <dbReference type="EnsemblBacteria" id="AEB43475">
        <property type="protein sequence ID" value="AEB43475"/>
        <property type="gene ID" value="VAB18032_11805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11805"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_11"/>
    <dbReference type="OMA" id="SDCKKTW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="291" mass="30870" checksum="081D6D28BB73AB0E" modified="2011-06-28" version="1">MNNRTVVITGANSGIGRAAARALAAKGARVVLAVRDPAKGQAAATTMTGKVLVRRLDLADLASVRTFAEGFQDPIDVLINNAGLMVPPLGRTADGFELQFGTNHLGHFALTNLLLPRIRGRVVTVSSNGHRAGTIDFDDLNWERKPYRAFRAYAQSKLANLLFTAELQRRLTEAASPVLAVAAHPGLAATNLIGHLDGEPLRRRLVHTVAVNFLAQSEQDGALPTLYAAVADIPGGSYAGPGGLLQGRGAPKLVGRSKAARDAATARRLWLASEELTGVRFPLPVTPSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBN3</accession>
    <name>F4FBN3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_11905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732164.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11905"/>
    <dbReference type="EnsemblBacteria" id="AEB43495">
        <property type="protein sequence ID" value="AEB43495"/>
        <property type="gene ID" value="VAB18032_11905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11905"/>
    <dbReference type="eggNOG" id="COG1814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_3_0_11"/>
    <dbReference type="OMA" id="NGGWLRP"/>
    <dbReference type="OrthoDB" id="1717935at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="24723" checksum="32ED440C5016F475" modified="2011-06-28" version="1">MTETPAALREPHHADVSGGWLRPAVFGAMDGLVTNIALIAGVGGGGVSPRNIVLTGTAGLVAGAISMALGEYTSVRSANEQIAAEVAKERRELERNPEGEARELAEIWVARGLPEDLARQMAEAIRRNPETALRVHVQEELGVNPDEQPNPWTAATSSFLCFSVGALVPLLPYLLGATSLALALAVGGLGLFVAGAVVSRFTNRRWWTGGLRQLLLGAAAAAATYAIGTLIGVQGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBS9</accession>
    <name>F4FBS9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18135"/>
    <dbReference type="EnsemblBacteria" id="AEB44729">
        <property type="protein sequence ID" value="AEB44729"/>
        <property type="gene ID" value="VAB18032_18135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18135"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_14_2_11"/>
    <dbReference type="OMA" id="NIERQPI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="533" mass="57101" checksum="C842E19F556C608A" modified="2011-06-28" version="1">MTVQHVHTSVLVAGGGVTGLTTAAYLASRGVPTVLVERRPAPSPHPRARGFNPRAVEVLRAVGLEAAVAEASRGFDGHTLRARVRSLTGEELLRHDLPGGADLGGLTPCRWALLSQDRLEPLIRARAEELGADVRFGTELTTFEQEDDGVRAQVVHRATGRVAEVRANYLVAADGPRSRVRERLSIPVHGRWGLHHQLSIVFDADLAAPLRGRRFAICQVQNDVVDGLLVHDDTLRQGTLYVRFDPSAEGGMDAFTRQRCAELVRAAIGDPDLPLSIRDTQPWELSAVTAARFRDGRVFLAGDAAHVMPPVSGFGASTGIQDAQNLAWKLAAVVSGEAGARLLDSYEQERLAVAALTVDQCRRRVTNGTGFAAPQRGEGMLDDLTLTFGLRYRSGAVLDEGVDPDVSAYGPADLTGRPGTRLPHVWLRHLGRRISTLDLPVAGPVLLAGPVGDGWRTAAARNELTLVAFDGDTDPDGGWERRFRAAPGEAILLRPDGYVAWRAPAPDDAALATAAGAVRGRADAVPTPVGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBV3</accession>
    <name>F4FBV3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733408.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18255"/>
    <dbReference type="EnsemblBacteria" id="AEB44753">
        <property type="protein sequence ID" value="AEB44753"/>
        <property type="gene ID" value="VAB18032_18255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18255"/>
    <dbReference type="eggNOG" id="COG2345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046979_3_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="440" mass="47810" checksum="60EA55BAF1F18F82" modified="2011-06-28" version="1">MIGIIGPEDSIRLVQEVAAGEGRAEEVSVRTYTDPEQAPELARELDDVCQVLLFTGRIPYSFAAAAGGLRAEIDYIRHAGIDLYRTLSRMLLAGAGQLPRVSVDTIEADTVRETYHDIELAPPTEILPIADSSGLLLSSLAEVTAYHRERYESGAVEACLTCLGAVHRELRERGVPVWRVEHTRASVRDALRRAWLAAEVRQSRATQIAVMMIEVAESATRPQDPYQAERQRLRLREALLEHAERMRGRLNTIDDRTLVITTTRGTVESAIARHRAGHASLLTLRGVDGEHTVGFGAGTTIAAAEANARQALALGRGGGDTHVVFPDGEIYSTRGSAVKQRLRETAPGVLRVSEQLRLGPLSTRRLLEALHQMDPNQVTARGLADAYGVEARSARRLLKALRAAGFAEEVGVHVSTGAGRPQTVYRVALQRLVGAIGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBV6</accession>
    <name>F4FBV6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the faeC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733411.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18270"/>
    <dbReference type="ESTHER" id="9actn-a0a2n7t5y3">
        <property type="family name" value="FaeC"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44756">
        <property type="protein sequence ID" value="AEB44756"/>
        <property type="gene ID" value="VAB18032_18270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18270"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_2_2_11"/>
    <dbReference type="OMA" id="WSYYGQQ"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034429">
        <property type="entry name" value="FaeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="entry name" value="PTHR38050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="PTHR38050:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307784" evidence="5">
        <location>
            <begin position="40"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="6">
        <location>
            <begin position="50"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="464" mass="49039" checksum="537DD5B129865DDD" modified="2011-06-28" version="1">MNVIGEARPASPPRRRWRSGLAAVAAAVLTAGTLVAVHAAPAAAATPDTNAWYVLVNRNSGKALDLYASSTADGARISQWTRNNGANQQWQFVDSGGGYYRIKSRHSGKVLDVYSFSTADGAAIVQWSDHNGTNQQFRLADSDGGHVRLISRHSNKVVEVQGASTADGGNIVQYADWNGANQQWQLVRVDGGGTTPPPPTGGTGCGKAPTLNSGTHTISSGGKSRSFILRVPANYNQNNPYRLIFGFHWRGGTMQDVSSGGTSGAAWSYYGQQEQSNNSAILVAPQGLGNGWGNAGGEDVVFVDDMIRHIESALCVNPRQRFALGFSWGGGMSYALACARADVFRAVAVIAGAQISGCSGGSQPIAYFGLHGISDNVLSIGQGRSLRDTFVRNNGCTAQNPPEPGAGSRTHITTAYSGCRAGYPVQWAAFDNGHMPGPVDGTYAESGVTTWTKGEIWRFFAQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC33</accession>
    <name>F4FC33_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24665"/>
    <dbReference type="EnsemblBacteria" id="AEB46031">
        <property type="protein sequence ID" value="AEB46031"/>
        <property type="gene ID" value="VAB18032_24665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24665"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082704_0_0_11"/>
    <dbReference type="OMA" id="DMARTAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="31443" checksum="66412169657CD460" modified="2011-06-28" version="1">MKRAIGMMHDNLGEQLTVDDLARAAMFSKFHFTRIFQRATGVSPARFLSALRLQRAKHLLKSTSLNVADISLRVGYNSVGTFSSRFTRSVGMPPTTYRRLAGFATHIPIDRSGRLGQPSAARVRGKIFPGPDVEPGLIFVGMFADRIPEGRPVRCAVLPEPGHFTFEEVPSGSWYLLAQSVTGDPQQSVWDASQPEQQVSVASYGPLTVRPDTDTEAELTLQPAGALDPPVLLALLDARKLALSMTGRDETGREKTGREEIGRTETAPTELRPQRHFASAQNHRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC45</accession>
    <name>F4FC45_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734695.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24725"/>
    <dbReference type="EnsemblBacteria" id="AEB46043">
        <property type="protein sequence ID" value="AEB46043"/>
        <property type="gene ID" value="VAB18032_24725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24725"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_2_0_11"/>
    <dbReference type="OMA" id="ADWHLLT"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="246"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="397" mass="43373" checksum="3E5BB102092F41E5" modified="2011-06-28" version="1">MEDAVTLATAPTHAELVRRTAELVPLLRQHAPWAEEHRRLHEETIEAMAAAGLYRMRVPARYGGFESSAETLVEVAAELARGDGAASWTASVWWIPTWMVGLFPDEVQDEVFATPDVRICGTLSPSGMAAPTDGGLTLNGRWQFISGAWHSHWQEIIAMSPTPDGGMQPLMMLVPMSDLQIVDDWHTSGMRGSGSVSTVAQDVFVPQHRVMPLGAILQGQYASKANADSPMFRAPLLGVANASSVGTVIGLARGAIELFLERLPGRKITYTGYESQAEAPITHLQIAEAVMKKDEAEFHGHRIATFVNERGRTGEPWTVLDRARSRADVGSVCRLGREVVDLLNQASGGSSIYLDVPIQRMARDMHAVTMHALHYPPTNMELYGRVLCGLSPNTLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC55</accession>
    <name>F4FC55_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-glucose/GDP-mannose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24775"/>
    <dbReference type="EnsemblBacteria" id="AEB46053">
        <property type="protein sequence ID" value="AEB46053"/>
        <property type="gene ID" value="VAB18032_24775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24775"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_11"/>
    <dbReference type="OMA" id="YPFRFVE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="314"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="418" mass="44515" checksum="B9FB51D7EEDB5A78" modified="2011-06-28" version="1">MTVCGLGYVGLALAQQMSTSGMVVIGYDVDPVVTAELAAGRSHIDDVLDDDLTAMSIAGFTVSSDPAALGASDAVVICVPTPLDAEGAPDLGAVRSAAAAVGARLRPGMLVVLESTSFPGTTDEVVRPILEQTSGLTAGVDFHLAFSPERIDPGNRVRTMAKTPKVVGGYTPGCRTRAIELYGRFVEKVVRARGTREAEMAKLLENTYRHVNIALVNEMAIFCHRFGIDIWDVVDCAATKPFGFEPFRPGPGVGGHCIPVDPHYLAFKARSVGLESTLIDAAERINAGMPAYVVERCADLLRTHGGELAGAHVLLLGVTYKPNIRDVRMSPAYDVVRDLRARGARVSYHDPFTPRFTVDGEPVPATADLTAALRAADLSLLLQDHTAHQPEVLTAHARLLFDARGVLAHAGDPHVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC74</accession>
    <name>F4FC74_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_00845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00845"/>
    <dbReference type="EnsemblBacteria" id="AEB47253">
        <property type="protein sequence ID" value="AEB47253"/>
        <property type="gene ID" value="VAB18032_00845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00845"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2343543_0_0_11"/>
    <dbReference type="OMA" id="WFTECVD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="11294" checksum="1592B0E656AF3563" modified="2011-06-28" version="1">MVAHVLRRGEVWRIEGARERLGLVISSDVYNSTAVPIVIVAEVVEAALLRDSPLAVPMGGWVVMPDRISSPMKKWFTECVDVADAETMRHVDRALRILQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCC2</accession>
    <name>F4FCC2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ordered locus">VAB18032_01085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735942.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01085"/>
    <dbReference type="EnsemblBacteria" id="AEB47301">
        <property type="protein sequence ID" value="AEB47301"/>
        <property type="gene ID" value="VAB18032_01085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01085"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_11"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="180" mass="19462" checksum="0F6B38CD8A29D9B1" modified="2011-06-28" version="1">MSRIGRKSIPVPSGVDVTIDGRTVKVKGPKGELSHTLAEPISIERAEDGQLSVNRPNDERKAKELHGLSRTLVANMIVGVTEGYRKSLEISGTGYRVTAKGKDLEFALGFSHPVTVPAPDGITFTVEKPTLFHVAGIDKQQVGEVAANIRKIRPPEPYKGKGVKYQGEVIRRKAGKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCE9</accession>
    <name>F4FCE9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05750"/>
    <dbReference type="EnsemblBacteria" id="AEB42276">
        <property type="protein sequence ID" value="AEB42276"/>
        <property type="gene ID" value="VAB18032_05750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05750"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_851606_0_0_11"/>
    <dbReference type="OMA" id="ALWAVEH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="302"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="386" mass="39117" checksum="7D7C0CF25AD6DFB7" modified="2011-06-28" version="1">MSMVGRVGELAELGRAWSTVVDGHRRSPAVAVVTGGAGVGKSLLVAAALDGFTPRPDVVLSGAARVHSPAPYDWLAAVLSGRDTSRLDLPADALAWLAQQPTAPRERYAPGTLLRLAVRTVRTLVGTGPAVLVVEDLHALDPASLNLVGELATADGLPALLMVATRPAAHAVAPALTGRTLARLCGVRGVVRQHLGPLRPAEVAEVLNQVYAGSAADTRLVHRVWQHTAGNPYALTELLAAHADRDTLITLAALSAAVSAAAGPEALGSAAVGPAVPGSTAVVPVGAVPADGVSATAVPGPRVAAVAELTGREVEVLDCLVAGMSNKQVARALGISVRTVTVHVSNLLRKTGAASRTEAALWAVRQRLTATPPPAGLAAPTAVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCN1</accession>
    <name>F4FCN1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ordered locus">VAB18032_12055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732194.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12055"/>
    <dbReference type="EnsemblBacteria" id="AEB43525">
        <property type="protein sequence ID" value="AEB43525"/>
        <property type="gene ID" value="VAB18032_12055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12055"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_11"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB43525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="32310" checksum="E18E6763413544B6" modified="2011-06-28" version="1">MTHDHVDAPARAVSRPFGRVITAMVTPFTAEGTLDLDGAARLANHLVAEQGNDALVINGTTGESPTTTEAEKEQLIRTVVEAVGDRARVLAGVGTNDTRHTIELAASAEKAGAHGLLVVTPYYNKPPQAGLLRHFTAVADATGLPVMLYDIPHRSGVPIETETLVRLAEHGRIVAVKDAKGDLTATSWVTSRTDLAYYSGEDSLTLPALAVGAVGVVGTSTHFSGADTKRMIEAYDAGDMSTALTLHRRLLPLFTGIFRTQGTILVKAGLTVQGLPAGPVRSPLVDATEDQVAQLRADCAAAGLPLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCU9</accession>
    <name>F4FCU9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nrdR</name>
        <name evidence="10" type="ordered locus">VAB18032_12395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732262.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12395"/>
    <dbReference type="EnsemblBacteria" id="AEB43593">
        <property type="protein sequence ID" value="AEB43593"/>
        <property type="gene ID" value="VAB18032_12395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12395"/>
    <dbReference type="eggNOG" id="COG1327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108412_1_0_11"/>
    <dbReference type="OMA" id="YRFTTYE"/>
    <dbReference type="OrthoDB" id="1551627at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="166" mass="18314" checksum="E50D6F3E5AA7FEAF" modified="2011-06-28" version="1">MRCPYCRHADSRVVDSREADDGQLIRRRRSCPECGKRFTTVEEAVLAVVKRSGVTEPFSRTKIIGGVRKACQGRPVDEDSIALLAQRVEETIRAKGAAEIPSHEVGLAILGPLRDLDEVAYLRFASVYRSFDSLADFEREIETLRAAARARQDAQAETAGAAGHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD03</accession>
    <name>F4FD03_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_18665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18665"/>
    <dbReference type="EnsemblBacteria" id="AEB44835">
        <property type="protein sequence ID" value="AEB44835"/>
        <property type="gene ID" value="VAB18032_18665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18665"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008033_2_0_11"/>
    <dbReference type="OMA" id="GTTCCEG"/>
    <dbReference type="OrthoDB" id="194265at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309265" evidence="3">
        <location>
            <begin position="37"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="218"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1126" mass="122104" checksum="DD213A1EEDEE3C76" modified="2011-06-28" version="1">MAQFEKLPVSRRQVLQASAVGVAAGALPATAAQAGARPDPTTSPRVITSTTTDVGPGATAPVRPFRLRDVTLGDGLFQEKRDRMKNYLRQLDERRFLVLFNNQAGRPNPAGVTAPGGWEDGGLLSGHWAGHVMTALAQGYADHGEPIFKSKLDWIVDELAACQTAITARMGSGGPGTEDPEEPQIGRVPGRFGSGLRLNGPSRAEHVTLPQEAISQLTDFTIATWVNLAAAQNWSRLFDFGQNATVNMFLTPRAGVTGSVPRFAITVSGSGGEQRIDGTSALPTNQWVHLAVTLTQQTGTLYVNGEQVGQNTNMTLSPANLGNPGNRWIGRSQYGDPMLNATVDEFHIFDRALSPQEIQSLQDSPAGSTGGGSIAWYRFEEEGGSTIRDASPNGRDGGIVASQSSGGALWVPTHPGYLGAIPEDAVLRLGPPRWAVYGSNATTNTWAPWYTQHKIMRGLLDAYYHTDNATALDVVVKMAGWAHLALTIGDKNHPAYTGPITRDNLNYMWDLYIAGETGGANEVFPEIYALTGDQKHLETAKLFDNRESLFDACVENRDILVVTPQNNPGRRRPDRLHANSHVPQFVGYLRVYEHSGDTEYFQAAKNFYGMVVPHRMYANGGTGGNYPGSNNNIELFQNRGNIANSIAQGGAETCTTYNLLKLARNLFFHEHDAAYLDYYERGLINQIAGSRADTTTVSNPQVTYFQPLTPGANRGYGNTGTCCGGTGVENHTKYQETIYFKSADGDTLWVNLYVASTLTWAERDFTITQQTDYPRADRTRLTVDGSGPLDIKLRVPGWVRKGFFVTINGLAQQVTATANSYLTLSRTWQRGDVIEIRMPFSIRIERALDRPDTQSVFWGPVLLQVLGNPGNGNYRELSLYRHLKRDGDYARAAITPAATTAAGDQLFTANGFTLRPYYIGDTQAASSYFRRVEPTVVFGAADTGVPNRKRNDGLPNYDIPVTDVPSPGTDGPTFLDLVWDEAPFANHGQFVSTVTRLAGEFVEAGLFTAAERSTIVSQAARSNAELDPGHTWNVEVQVRTQLIGGRVYLAVNAVNADEVPLTIELDTAYGSRTVTDVAVGKPAYQSFNTRLAAIPAGTVTVVVTGTVDGESVTTRIEAAYPAVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD46</accession>
    <name>F4FD46_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734728.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24890"/>
    <dbReference type="EnsemblBacteria" id="AEB46076">
        <property type="protein sequence ID" value="AEB46076"/>
        <property type="gene ID" value="VAB18032_24890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24890"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_3_11"/>
    <dbReference type="OMA" id="FQIAPEM"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="959"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2007"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2081"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="2107" mass="225922" checksum="E9200E0FFEE2C48B" modified="2011-06-28" version="1">MSDPSAGSRPLNAAQLGVWYAQRIDPGNPVHNMGGYLEIQGPLDPDALIAAVCVLVGEDETLRLRFTEVDGTPTQQLGPAPDFAPRLVDLSAEADPRAVALRHMHDDLNRPLDLEHDRLFQHEIYRLGPEHHLWYLRAHHLVQDGYSATILRRRAAELYTALVTDRDGAGAPLGSFTAMLDDQDRYVGSRAQQRDAAYWRKLMADVAYAPPAPAGKPANRVTRQVTRLDGPGFDRLREFAQRAGTTWQQALITAAVLHRRMWTGDDDVLLGLPLPGRLDPRSAATPGMMATILPLYCRVDPAQTAEELAARVAALALRAQWHQRYDGDDLRRDLGWPADQGRQFGPVINFVAGDDHDDFAGLPARYHLLSTGGTIEDVGLTVTHHPEGGLRIDVSTDTAYTQTLDLDAYQRTFHRILANMTGRPGVTVAEIEALDAADRELVLREWNATAVPVADRSLAELFTAQAAASPQAPALVCGGVVLSYGELAQRSGQLANHLLSIGVGRGDVVGVLLERGIDFAVAVVAVTRTGAAYSILDPDFPDERLSFVLRETAASALVTREASTSRIDAACPVVRVDTDAAAIAGHATGDPQPRIDPGDVACVMFTSGSTGAPKGVLAPHRALVGTVQGQRYASFGPGEVFLQCSPVSWDAFSLEFWGALLFGGVCVLHPGQRPDPTVIAALVPQHGVSMLQLSSGLFNVLVDEYPEVFAGVRVAFTGGEPSSGPHVARVAARHPHLRVANAYGPAESMGFTTTFDVPADITGVGVPVGRAVANKRAYVLDRHLRPVPVGVAGEIYLAGVGLADGYLNQAAVTAQRFVADPFGGDGERLYRTGDLARWSADGQLEFVGRIDGQVKVRGFRVEPGEIEATLLGHADVAQAVVLASPDGNGTLRLIAYVVPRSTGTDGTALTGWLRQRLPEHMVPSVVVLLDRIPLTANGKVDRRALPEPEFGATATTRRAPRDAREEILCGLYAEVLGITEVGVDDSFFDLGGHSLLAARLAARARAVLGVELSIRDIFQSPTVAALTAGLPATGTARTRPPLVAATHGDQLPLSYAQRRLWLIDSIEGPGTTYNVPMTFRLRGALDVDALTAALGDLVDRHQVLRTVIAAVDGRPYQQLLAPAPVTVTRREATAEDLDRQLVAAAGHVFDLAAEAPLRVTLFALGDEEYELLILLHHIATDGQSLRPLLGDLATAYAARWAGRAPDWMPLPVQYADYALWQRAVLGDRDDQDSTHHADLRYWRQALAGLPEETGLPLDRPRPAVADHRGDAVAVRIDPEVARRVREVAREQRCTAFMVLQAALALTLRRFGAGTDIAIGTPVAGRSDEDLAPLVGFFVNTIVLRTDTSGNPSFADLLVRVRGADLDAFAHQELPFDLLLEDLNPVRSLARHPLFQICLGFDDATDAELHLPGLRCERGSVVVTGAAKFDLEFLLRDEGADGIGGGLVYRTAIFDEATVQRLVAALERTLRQVLADPSRPVDEVDALDPVERSAVLHDWNTTAVDVADESLAHRFAAQVAADPHAVALRHETMALTYGELDAAANRLARHLSAAGVRRGDLVGVLLERGTDFAVAVVAVVKTGAAYAVLDPEFPDERLHRIVTETGAAALVSRAALAERITTDAPVVRVDTDAALIAAQPATDPGVPVGPDDVACVMFTSGSTGAPKGILTSHRALVGTLAGQSYADFGPDQVFLQCSPVSWDAFSLEFWGALLFGGTCVLQPGQRPEPALIATLVREHRVTMLQLSSGLFNLLVDEYPQAFDGVRYAFTGGETSSVTHVARILARCPDLRVGNAYGPAESMGFSTVYPVPDDFTDTSSLPVGRAVANKRTYVLDDALRPAPVGVVGEVYLAGIGLAHGYLNQPGTTAQRFVPDPFGAPGDRLYRTGDLARWTVDGQLEFAGRLDGQVKVRGFRVEPGEIESVLRGHDQVAQAAVIAVPDPTGTMRLIAYVVGDTDPAGLRPWLRQRLPEHMVPAAVIPLDRMPLTANGKLDRRALPEPEFTAGTGRAARDAREEILCGVYAEILGVPTVSIDDDFFDLGGHSLLAAKLAARVCAILGTQLTIRDIFQAPTIAALAAQLPSAAPARSRPTLRRRTEAGRALPSSPQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDI6</accession>
    <name>F4FDI6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736032.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01565"/>
    <dbReference type="EnsemblBacteria" id="AEB47397">
        <property type="protein sequence ID" value="AEB47397"/>
        <property type="gene ID" value="VAB18032_01565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01565"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019249_1_0_11"/>
    <dbReference type="OMA" id="FAFIDDH"/>
    <dbReference type="OrthoDB" id="1255662at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="123"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="790" mass="81480" checksum="68EDB168680708E6" modified="2011-06-28" version="1">MGAPPAADRALSRPRHRLVAALAALVALAAVGTLALLAIRPPTPRPTDAPRDEFSADRAYEHVSVVARQRHPAGSAANDEVRAHLEARLRALGLTPEVQDTVAEEAGQLSGAAGGATLARVRNVVARLAGTDPTGTVFLVAHYDAVQTGPGGNDNAAGVAAILEVARALTSGPRPRNDLVFVFTDAEEACLCGASAFAADHPLAAGKGVVLNLEARGSTGPVIMFETSPENAALVDVFGRAAPHPVGTSFAVEVYRALPNDTDFTAFLDHGFVGLNSAYLDGGAIYHTPLDTPESMDRASLQHHGANALGLAREFGRIDLADLAADHDATYFPMPGGLARYPGTLVLPLALLALAGVIVLGWWARRRGRVTGGRLAAGFGLALVPIVVAPLGAQLLWAAISVIRPGNAMLLDPYRPIWYRLTVLALAAAVLFAWYALTRRRVGPAALAIGGLGWLALLGVLLAVLVPGGAYLATLPALAGVLAGLVAVAAPIDGPVPVIAVTLTGAVAVVILLPVVVLLFPALGMAMGGVAALFAVLLGLAALPVVDLLHPEAGGQRGMDALRARRRGALPAGAAALTAAVLAGVGIAADRFDAAHPAPTHLMYALDAGTGQARWLSLESDPQPWTAEYVDSTVSIADDFPGLGRDELLGGPAQAADLPAPRLEVLSDTGTAGERTLRLRFTPQRQVRLATLHVDTSTAVVRSAQVAGRPVPVEQREGRWGFGVVFHAPPTEGFEVVLTVVPSATPVALRATDVSDGLDALPGFRPRPPGVGVVGSHSSEMLAVARTYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDI7</accession>
    <name>F4FDI7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber evidence="12">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_06130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731023.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06130"/>
    <dbReference type="EnsemblBacteria" id="AEB42350">
        <property type="protein sequence ID" value="AEB42350"/>
        <property type="gene ID" value="VAB18032_06130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06130"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_11"/>
    <dbReference type="OMA" id="CDDVIMD"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="13">
        <location>
            <begin position="335"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB42350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="438" mass="47544" checksum="DD7E1734909DDD91" modified="2011-06-28" version="1">MTTPRPETLAKLTPVLTKRWLSPDAWQIGTYEKLDGYAALRKALKAHPDDLIQLVKDSGLRGRGGAGFPTGLKWGFIPQGDGKPHYLVVNADEGEPGTCKDLPLMTHDPHSLVEGVIIASYAIRANRAYIYIRGEAVHAARRLRNAVEEAKAKGYLGKNILGSGFDLELVVHSGAGAYICGEETALLDSLEGFRGQPRLRPPFPATHGLYASPTVVNNVGTIASVPYIVLGGADWWKSMGTEKSAGPMIYSLSGRIANPGQYECGLGITLRELIELAGGMQPGHNLRFWTPGGSSTPLLTAEHLDVPLDFEGVAAAGSILGTTATQIFSDQDCPVYATYRWLEFYHHESCGKCTPCREGNYWMVRVYRRILAGQGTHDDLDTLLDTCDNILGRSFCGLGDGATSSVTSSLKYFKQDYLDYIEGRTAPKLSDKQLVGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDM3</accession>
    <name>F4FDM3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06310"/>
    <dbReference type="EnsemblBacteria" id="AEB42386">
        <property type="protein sequence ID" value="AEB42386"/>
        <property type="gene ID" value="VAB18032_06310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06310"/>
    <dbReference type="eggNOG" id="ENOG5033B4F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104210_1_1_11"/>
    <dbReference type="OMA" id="DCERQGE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="11848" checksum="D3E02E555E21E22E" modified="2011-06-28" version="1">MRTERDRGGATICLLAVGLVFVLAGLFGAGVGAARMARQQARVAADFGALAGAARALQDEPTACARAAEIVAANGAGLVRCHLDGLDVLVTAELTVEPLPGLRRVATVTSRAGPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDQ4</accession>
    <name>F4FDQ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731090.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06465"/>
    <dbReference type="EnsemblBacteria" id="AEB42417">
        <property type="protein sequence ID" value="AEB42417"/>
        <property type="gene ID" value="VAB18032_06465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06465"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083829_0_0_11"/>
    <dbReference type="OMA" id="GGFDFWR"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="31740" checksum="FAEC6E74DED2291F" modified="2011-06-28" version="1">MNRPLDTGTHADFRAERLLDVLIPTRDRPAELAVTLSGLAAQEGVPGFGVVVSDQSDHEPGYAHPAAATMVRALRHRGHPVLLTRRLPRRGLAEHRASLLAASAARYVLCLDDDVWMEPGTLRRLVTAIEELGCGFVGNAVHGLSYLHDVRPQTHRHYQEWSGRPVPERIGPDTPEWDRAQIHSAANLLHVTEALALPEGSWRAYRISWIGGCVLYDRAKLVDSGGFDFWRRVPPRHQGEDVAAQLAVLARHGGAGVLPSGAYHLESPTTVTDRDVEAWEVVLADDLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDR5</accession>
    <name>F4FDR5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase ligd, polymerase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731101.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06520"/>
    <dbReference type="EnsemblBacteria" id="AEB42428">
        <property type="protein sequence ID" value="AEB42428"/>
        <property type="gene ID" value="VAB18032_06520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06520"/>
    <dbReference type="eggNOG" id="COG3285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_1_2_11"/>
    <dbReference type="OMA" id="CCEVALW"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04863">
        <property type="entry name" value="MtLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033649">
        <property type="entry name" value="MtLigD_Pol-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="33105" checksum="C802920B6129DD16" modified="2011-06-28" version="1">MPAERFRVEVEGRTLDLSNLDKVLYPQAGFTKGEVIDYYTRIAPVLLPHLADRALTRIRYPNGVDGNSFFEKNAPAATPSWVRTENLPAPGSSKGRETIDYVVADDLPTLVWLANLAALELHTPQWKVGEHPDLMVVDLDPGAPASLKQCCQVALLLRDRLAADGVDAYPKTSGKKGMQLSCPIAGTQSSDDVSGYARRIAQELEREHPKLIVSKMAKNLRPGKIFIDWSQNNAAKTTVAPYSLRAQPVPSVSAPLTWDEVAAGAAGKRPSSRPYTAGEVLKRVDEHGDLLAPLLDLGPALPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDR9</accession>
    <name>F4FDR9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YCII-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732269.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12430"/>
    <dbReference type="EnsemblBacteria" id="AEB43600">
        <property type="protein sequence ID" value="AEB43600"/>
        <property type="gene ID" value="VAB18032_12430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12430"/>
    <dbReference type="eggNOG" id="COG3795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130902_2_2_11"/>
    <dbReference type="OMA" id="EIPAAWD"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12036" checksum="2A2C6AE590BD01CF" modified="2011-06-28" version="1">MPQYAVLIYSPAPADPMELTPDYVALLEQYPAKVTELGGRIVTGFALQPSTTAAAIRGDLVTDGPFIEAKEVVAGFFVLEAPDRDVALEIAKLNPATIHGAVEVRPLFVAPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE11</accession>
    <name>F4FE11_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18890"/>
    <dbReference type="EnsemblBacteria" id="AEB44880">
        <property type="protein sequence ID" value="AEB44880"/>
        <property type="gene ID" value="VAB18032_18890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18890"/>
    <dbReference type="eggNOG" id="COG3801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138549_1_1_11"/>
    <dbReference type="OMA" id="VWSYPER"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="128" mass="14288" checksum="4B5F1D82E7824FBD" modified="2011-06-28" version="1">MGATMADADDVRRLALALPQVVEIDSDGFDFRVADKGFVWSYPERRPGKPRTIRTDIAVLYVGDEAEKQALLLGEPETFFTTPGYDGLPLVMLRLTRVDAERLAELVTDAWRMRAPESVAAEVDDRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE67</accession>
    <name>F4FE67_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19170"/>
    <dbReference type="EnsemblBacteria" id="AEB44936">
        <property type="protein sequence ID" value="AEB44936"/>
        <property type="gene ID" value="VAB18032_19170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19170"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_11"/>
    <dbReference type="OMA" id="ELWHATT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="24638" checksum="16CFA4A62031540E" modified="2011-06-28" version="1">MPDLIDIMLGGLRLSLRVWPAADPARTPVVLLPATGRTAEDWDVIAAELAADRTVYGVDLRGHGGSDWPGAYRLELFADDVLGVLGHLDSGPVDLIGHSLGGLVACRAAAARPQHIRRLVLEDIGFPHPRPPAPPQRPAGELPFDWRVVEQVRPEIDDPGRDWAEVIARITVPTLLIGGGPSSPVPQQHIAELANRLADARLVTIPTGHLIHETAPTAYLNTLTTFLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEW3</accession>
    <name>F4FEW3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma-24 subunit, ECF subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_06915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731180.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06915"/>
    <dbReference type="EnsemblBacteria" id="AEB42507">
        <property type="protein sequence ID" value="AEB42507"/>
        <property type="gene ID" value="VAB18032_06915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06915"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OMA" id="WARINRH"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="103"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="19132" checksum="EDCB091B349E0046" modified="2011-06-28" version="1">MGDRDTAFAEYFAARSSAMRGTAYLLCGDWHRAEDLVQTAFTKLYLAWHRVSRHEVLDAYLRQIIVRTFLDERRRGWWRREQLDDADPEHPAPTDAPENRLVMLQALAAVPPRQRAVLVLRYWEDLPVDEVAHLLRCSPGTVKSQAARGLDTLRGLLSPTYSGTERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEW7</accession>
    <name>F4FEW7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tap domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732347.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12825"/>
    <dbReference type="EnsemblBacteria" id="AEB43679">
        <property type="protein sequence ID" value="AEB43679"/>
        <property type="gene ID" value="VAB18032_12825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12825"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_3_1_11"/>
    <dbReference type="OMA" id="GHCAVAS"/>
    <dbReference type="OrthoDB" id="665798at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309303" evidence="1">
        <location>
            <begin position="29"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="528" mass="56319" checksum="8FA398E769699582" modified="2011-06-28" version="1">MTRTTDPIRRRRRLTIAGLVSAAVVAAGCTLPALAPRSDVEGEAAPPGTTPTWQACPEVADEVVGRGAPGIRYECTRIQVPRDWAGGSGATTGPGAGETFEIALIRARSDKQRDRIGSLLVNPGGPGGSGVDTAVYLSFGEQYGGLPDRIMERFDIVGFDPRGVARSSPVECISDADLDAVFGSDPDPQNQESFDDLVALANRIGRGCGDKYGDQLPLYGTEQAARDMDAIRAAVGDDKLTYLGYSYGTLLGATYAQLFPARVRALVLDGAIDPRQGLIEGSESQAKGFERAFDNFHRWCAANAARCPIAPDARAAVISAIDKARVSPARSADGREATAGWVFYAVISSLYTESGWQELARAIDQLEGGNPQGVFRLADSYADRDDKGHYTNLFDANTAINCADEEERPNLDRIRQLQSQWRTQYPLFGPALATGLISCTEWPGGSDPYPTGRADGAPPILVVGTTGDPATPYEQTPALAEMLGVGRVLTWEGEGHTAYPQTACITQAVDAYLIDLTVPAEGKRCPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF12</accession>
    <name>F4FF12_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13050"/>
    <dbReference type="EnsemblBacteria" id="AEB43724">
        <property type="protein sequence ID" value="AEB43724"/>
        <property type="gene ID" value="VAB18032_13050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13050"/>
    <dbReference type="eggNOG" id="COG3268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810944_0_0_11"/>
    <dbReference type="OMA" id="AYGLSSW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="373" mass="39094" checksum="63CEE2FA140BD69E" modified="2011-06-28" version="1">MDHFEYLGAGVGSGQTVAVFGAYGHTGRFVVAELRERGYVPLLLGRDQDKLRALAQTHPGLGVRQASVDDPASIDRALEGVAAVINCAGPFAATAAPMVEAALRAGIAYVDVAAEIEANLDTFAHFAERANAAGTVVVPAMAFYGGLGDLLVTTAMGDWTTADEVHVAYGLSSWRPTGGTVASGVVSQQRRGGRRVRYTGGHVEYHDDALPTVQWHFPAPLGPQSVIAEFTMADIVTIASHLAVPEIRTYMTAKAAAELSAPYASAPDAVDERGRSAQTFVVDVLVRSGGTERRLAAAGQDIYAVSAPLAVEAVARILTGRTRGTGVASAGAIFDAPDFLRAISSHLSLHLSPGYAADQRSRPRPGVCSMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF59</accession>
    <name>F4FF59_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_19310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733619.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19310"/>
    <dbReference type="EnsemblBacteria" id="AEB44964">
        <property type="protein sequence ID" value="AEB44964"/>
        <property type="gene ID" value="VAB18032_19310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19310"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_2_11"/>
    <dbReference type="OMA" id="HPFFAPS"/>
    <dbReference type="OrthoDB" id="365211at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="6">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="531" mass="57111" checksum="0106410E712C5598" modified="2011-06-28" version="1">MAEFDYIVVGAGSAGCVLANRLTEDPGTRVLLIEAGGWDRSPWVRIPKGFSRLMDDRRTAWHYPAQVRAGQQEVWQRGRLVGGSSSINGMVYGRGDRLDYDELERLGNPGWGWDTMLPIFKRLEDNPLGASQVRGVGGPLRLSTATGTDEISENAIAAGVELGWQRVDDLNATDDERIGYLMATIRDGRRSNAADAFLHPVRNRPNLTVVVDTVVVRILIENGQAVGVCTRQGGRSVEHRAAAEVVLAAGAIATPQLLQVSGIGPAETLRRAGVPVLADRPRVGVGMREHRTTPMQFRLAGRAGYNARLSSPLGQAREMLRYLTTRRGLLALPVYDVGAYFRSAPDVGHPDAQLLLAPFSAAPRRPGRAIELESESGLMAQVTVTRPESEGSLAITSADPGTAPAIVANYFTAPHDRRVAVGAFRRVRELFGTAPIAKRIVAETLPGPAVQDDEEIIEAGLALGYCGYHAVGTCAMGPGDDFVVDSRLRVRGVAGLRVVDASVLPILVSGYLNAPVMALAWRAADLIRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF68</accession>
    <name>F4FF68_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733628.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19355"/>
    <dbReference type="EnsemblBacteria" id="AEB44973">
        <property type="protein sequence ID" value="AEB44973"/>
        <property type="gene ID" value="VAB18032_19355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19355"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_11"/>
    <dbReference type="OMA" id="NQYVRLV"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313866" evidence="3">
        <location>
            <begin position="26"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="83"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="511" mass="55886" checksum="39452A26D600CEBB" modified="2011-06-28" version="1">MSSTRFGLAGATLALLLTVSVGCSAGEGVDVDGGNEAGAGGVLNAAIGGEPDQLDPHKTSAYYSFQVLENVFDTLVEPDANLEMQPSLATGWTTSDDQLTWTFTLREGVKFSDGTPLTAEDVVYSYNRIIDEKLNTAYKFGTVKSVAASNPTTVVITLSAPTPNLLANLGGFKGVAIVQKANVESGEITTKPIGSGPFAIGGYTSGDNIQLVRNDNYWGERPKLDGVRFTFVSDPTVALQNLRGNEVQWTDNLPPQQVPALLDGDEPTVESVPSTDYWYLALNQARKPYDDVNVRRAIAFALDREAITKAAKFGLATVNQTAIPQNSAFYYEYAPYSHDPNQARQLLDQAGVNDLTMDLMVTSEYPETVTAAQVIASQLAGIGVNVKIRTLDFAQWLDEQGNGNFDSFMLGWLGNIDPDEFYYAQHHSGGTFNFHKYNNPAVDQLLDRARTQTDQGARKQQYEQVAKQIVDDASYIYLYNPDVAQGWSKQVTGYQVRTDRAIRFRDVALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF70</accession>
    <name>F4FF70_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_19365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733630.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19365"/>
    <dbReference type="EnsemblBacteria" id="AEB44975">
        <property type="protein sequence ID" value="AEB44975"/>
        <property type="gene ID" value="VAB18032_19365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19365"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_11"/>
    <dbReference type="OMA" id="FIRSVYI"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="31397" checksum="7C529A02FCF82C5C" modified="2011-06-28" version="1">MSAPTVNPSEGQLRRAVSALRHDPLALTGTAVLVLLVVVGVAGPWLAPAGINDVDVDRMLQAPSWAHPFGTDELGRDVLSRVMVAARVSLQVGAVSVGIALVAGVTLGLFAGYYRGWLDNLLMRCMDVLFAFPVLLLAVAIVAVLGPGLLTAMIAIGVVYTPIFARVTRAGVLSVREQVFVRAAVSIGASDLRIMRRHVLPNIAAPLIVQTSLSLAFAILSEAALSFLGLGVQPPAPAWGRMLYDGRGFVTDAWWLGVFPGAAIFCTVLAFNLVGDALRDVLDPRQLTVNEARRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFA3</accession>
    <name>F4FFA3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733663.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19530"/>
    <dbReference type="EnsemblBacteria" id="AEB45008">
        <property type="protein sequence ID" value="AEB45008"/>
        <property type="gene ID" value="VAB18032_19530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19530"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013093_3_3_11"/>
    <dbReference type="OMA" id="AMTPTMG"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309313" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="7">
        <location>
            <begin position="423"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="550" mass="59254" checksum="46D3FE743C4AC222" modified="2011-06-28" version="1">MRARPRWLAVLSVLVLTLTTVVVDGLHSPKPAQALNNGVARTPPMGWNTWNTFGCNINETLIRQMADAIVNTGMRDLGYKYVVVDDCWFDPNRDAQGNLQAHAGRFPSGMKALGDYLHSRGLLFGLYQVPREKTCAQYFGAWPGSTGSLGHEYQDARQFAAWGVDFLKYDWCSPWGTINDQIAGFSLMRDALAATGRPIVYSINPNSIHEKTGPQRNWGDIANMWRTTEDITNAWNTGQTNGYPMGIQNIVNVNVPIASYASPGSFNDPDMLVVGNGGMTDTEMRSHFALWAIMAAPLIAGNDIRNASAATLDILRNQNLVAINQDSLALQAVQVANDGIRRVLAKRLANGDVAVALFNQGNSTTTVSTTAAAIGKSGNSFTLRDAWTNTTSTSTGTISASVPAHGTVVYRVSGGGTTTPPPPPTTFRLRSESSGRCLDVNNSGTANGTATLIWDCHTASNQSFTQNGQALQVLGKCLDISPTATPGTPVQIWDCNGGTNQQWTFNSNGTISNVRSPNLCLDVNNNGTANGTPVIVWTCHTAPNQRWTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFU3</accession>
    <name>F4FFU3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731196.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06995"/>
    <dbReference type="EnsemblBacteria" id="AEB42523">
        <property type="protein sequence ID" value="AEB42523"/>
        <property type="gene ID" value="VAB18032_06995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06995"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_2_0_11"/>
    <dbReference type="OMA" id="MTELAFT"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="401" mass="43834" checksum="686F131EF72D5EB7" modified="2011-06-28" version="1">MDASGLPPRFDALDPAVLEDPYPTYARLRAAGPLCRFGPGSWGVTRHADVVALQRDPRLGSEFPEAYHHLSVGAGPASHFFQRIMLYRDPPDHVRLRRLMSGAFTPAVVRRMRGYIEQTVDDLLAPALESGSCDVVRELAYPLPVLVVSTLMGIPPEAHDDVRLHAMRLGRAFSAIVPADARDAAHESVQWLRAYIGGLLDERRKAPGDDLLSTLLQAEDDGDRLSHDEIVDNTVFSFFAGFETTVHLITNGFAALLRAPDQFALLRSDPGLVPGAVEEFLRFEAPIQGTARLVREPVTIGSRTVRAGRVLVLMLGSANHDEAVFHDPGTLDVTRNPNPHVTFGGGGHLCLGAFLARTEAQVVFDWVLRRTSSVEQAGDLVRESDTPFRAFAHVPLAIKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFX0</accession>
    <name>F4FFX0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_07130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731223.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07130"/>
    <dbReference type="EnsemblBacteria" id="AEB42550">
        <property type="protein sequence ID" value="AEB42550"/>
        <property type="gene ID" value="VAB18032_07130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07130"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_2_3_11"/>
    <dbReference type="OMA" id="YPWDDPP"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="267"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="389" mass="40339" checksum="B8C9B243D4C5200E" modified="2011-06-28" version="1">MTAQDREPVVVAAVRTPIGKRGGALAGLKGVELLRHVLAAVIDAAGVTPDVVEQVVGGCVTQAGEQSLNVTRNAWLSTGWDPAVGCTTVDVSCGSAQQANHLVAALIGSGAIDVGIACGVESMSRVPIGVNLYNGPGHYKTADYPWDDPPKAQFGGAERIAARQGLTRADVDAYGVLSQQRAAAAWAAGHFDREVVGIDAPGDGEDAGSRRVDRDEGLRETTLEGLAKLAPNVPDGVHTAGTTSQVSDGASAILWMSRARARALGLRPRARMLTQVVTGADPYYLLDGPVVATGRALERAGMTLADLDLVEVNEAFAGVVLNWAQQYDSDLERVNVNGGAIALGHPLGSSGTRLLVTALHELERRDAQTALVTMCCGGSLGTATILARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG04</accession>
    <name>F4FG04_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42584">
        <property type="protein sequence ID" value="AEB42584"/>
        <property type="gene ID" value="VAB18032_07300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07300"/>
    <dbReference type="HOGENOM" id="CLU_2811260_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="67" mass="7316" checksum="F4909EBF329D1B0E" modified="2011-06-28" version="1">MQIPTSDTRIPTGLHILLNPTSTRLPAIAPATATADCQVPAGHRRVTVSTDLLHHSATTRGPRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGC8</accession>
    <name>F4FGC8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733721.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19820"/>
    <dbReference type="EnsemblBacteria" id="AEB45066">
        <property type="protein sequence ID" value="AEB45066"/>
        <property type="gene ID" value="VAB18032_19820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19820"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OMA" id="WLDTANC"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="35413" checksum="E89365C0E3BAC4FA" modified="2011-06-28" version="1">MTSDHFDEARRPAVSALVLGAMTFGTLVDEKTSFELLDRFVERGGEWIDTADCYAFWHSPDGRGGDSERILGRWLAARPGVRARVRIATKVGAEPLWKGSWPAHRAGLSRRAISDAFAGSLDRLGVEYVDLLWLHQEDRATPIEESVDAIAEQVTAGTVRRVGASNHPAWRIERARAYATARGTMPIDAFQLNATYLRVRPGTRPDGVIHPHGVLSDEQLDFARAHRMDLWAYTPLLSGAYDNSAKSIPQVYDHPGNTRRLAALDAVARDTGATRGQVVLAWLVSQGIRPILGGSKLHQLDAALDGVALTLDETHLARLNSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGE1</accession>
    <name>F4FGE1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19885"/>
    <dbReference type="EnsemblBacteria" id="AEB45079">
        <property type="protein sequence ID" value="AEB45079"/>
        <property type="gene ID" value="VAB18032_19885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19885"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097054_1_0_11"/>
    <dbReference type="OMA" id="REACALD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="17325" checksum="23D5D8D3660B9B5A" modified="2011-06-28" version="1">MAARVSAVIPAPRRPGPTPAKVARPRQVSALQRRQLSYAPEPDGQADPGEIVWTWVSYEDDPRQGKDRPVLVVGRHSRTLFGLMLSSRDRDGERHWLALGPGEWDRDKRPSWVRLDRVLTMREDGIRREGAVLDRPRFDRVSAALRAGYGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGH6</accession>
    <name>F4FGH6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_26065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734962.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26065"/>
    <dbReference type="EnsemblBacteria" id="AEB46311">
        <property type="protein sequence ID" value="AEB46311"/>
        <property type="gene ID" value="VAB18032_26065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26065"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_14_3_11"/>
    <dbReference type="OMA" id="HHDIPKS"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="52"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="241"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="9">
        <location>
            <begin position="560"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB46311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="634" mass="68898" checksum="932739975A5C0D1A" modified="2011-06-28" version="1">MASPADVRTSDLSIADVTDSDAPAGAKVTAALEVLRRVFGYDAFRGFQREVIDHVVDGGDALVLMPTGGGKSLCYQIPALVRDGVAVVISPLIALMQDQVDALTAVGVKAGFLNSTLDLDTRRLVEAEFVAGEIDLLYLAPEALASRATLSLLDRGRISLFAIDEAHCVSQWGHDFRPDYLNLSMLHERWPGVPRIALTATATSATRSEIATRLNLTEARHFVASFDRPNIQYRIVPKREPRKQLLALLRDEHPGDAGIVYCLSRASVEKTAEFLVANGIDALPYHAGLDAATRAANQQRFLRADGVVMVATIAFGMGIDKPDVRFVAHLDLPKSVEGYYQETGRAGRDGLPSTAWLAYGLQDVVQQRKMIDTSEGDLAHRRNLAAHLDAMLALCETVRCRRVQLLEYFGEPASGNCGNCDTCLEPPESWDGTVAAQKLLSTVFRLDRERNQRFGAGHCIDILLGRSNDKITQHRHDSLTVFGIGGELSEAEWRGVVRQLLAEGLLAVEGDYGTLALTDASAEVLGRRRTVMLRREAARPARAARTAKPRGAATVVADLSPEATGTFERLRAWRAATAKEQGVPAYVIFHDATLRQIAAEMPTSLAELSGISGVGENKLAKYGEQILNVLTNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGK7</accession>
    <name>F4FGK7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase sdr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26220"/>
    <dbReference type="EnsemblBacteria" id="AEB46342">
        <property type="protein sequence ID" value="AEB46342"/>
        <property type="gene ID" value="VAB18032_26220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26220"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314945_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="20524" checksum="84674904AB6E97AB" modified="2011-06-28" version="1">MPRRVVVVTGAGTGIGRATARGFSADGAQVLAVGRRGAPLADTATGHPLIAPLAVDVTAADAPRRVVDAALDRYGRLDVLVNNAGIAGAGRLADLDEAATHAQLATNLLAAAVPGRPVLPRLGPATTIRQCRQARSAQPASPVAGSAGRQAGPTDGARPTDGAGPTDGSSAGRSAGWHKGNGVDGCGSGNWPGPPAAPLGRCATTSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGQ0</accession>
    <name>F4FGQ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_02380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02380"/>
    <dbReference type="EnsemblBacteria" id="AEB47560">
        <property type="protein sequence ID" value="AEB47560"/>
        <property type="gene ID" value="VAB18032_02380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02380"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="GEIQLIC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="307" mass="32500" checksum="3CCC2A98721CF986" modified="2011-06-28" version="1">MRVEAGEVHGFLGPNGSGKTTTLRTLLGLIRSDGGRMSILGQEVPAALPQVARQVGAIVESPQFFPHFSARDTLSLLASADEVPAQRVDEVLELVGLRDRAGERVKTYSLGMKQRLAVASALLKSPRLLILDEPANGLDPGGIREMRTLVRNLAESGMTVVLSSHILGEIQLICDSVTIISLGRRVAFGPVDEVLAQHSSGGVRVRLEAVMDLPLAANALHGNGYRVTANQDHLMVSGVDKPATITRLLAEQGLYVSELAPVTVDLESVFLELTNTAPVPGQHRQVDHSVRVDGAAPSAPTGGGWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGU3</accession>
    <name>F4FGU3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02595"/>
    <dbReference type="EnsemblBacteria" id="AEB47603">
        <property type="protein sequence ID" value="AEB47603"/>
        <property type="gene ID" value="VAB18032_02595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02595"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046423_0_0_11"/>
    <dbReference type="OMA" id="DALCMAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="469" mass="48498" checksum="5C26B4B32B89F7FF" modified="2011-06-28" version="1">MSADVPADPPAADGYLQRATLLAELGRYDEAVGELGFALALDPVHVETLVMLARVHLAADRPVEALAAAESAAAAAPGQVPPLVLRGLALGDLERYGEAARTADEILALGPQDAYAQRSAAAILAGSRNGQPALNAAWHAVELAPEEPQGHLVLGLVAANMRMFDLAERAYREALRLDPRLAEVSEDVGVLRLEQRRWSATLERLAEAAVPTLPPTDPRRTEVNRPEQAPDDLPRQGPHPSSGPGTDQQPGRPTEGRTGPGGSADGGTWPSGSADGGTWPSGSADGGTWPGGTPAGWDTPSGERRPGPGPQDGGEQPSHGGAEFPEPGRFGGPVDAGRAGTGPFVARRPVPAALRQFVLWGAGWSMVAALVIACSATTGSGFSRFMAVLAAVGGGIVLWRHASRLPGLTRTVLPVLQRTDRPLVLAVYAAAAAPALILLYALVGTPWPLVLSIGIATVAQLTIVSRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGY0</accession>
    <name>F4FGY0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative branched-chain amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731267.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07350"/>
    <dbReference type="EnsemblBacteria" id="AEB42594">
        <property type="protein sequence ID" value="AEB42594"/>
        <property type="gene ID" value="VAB18032_07350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07350"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_1_2_11"/>
    <dbReference type="OMA" id="QTTFHYA"/>
    <dbReference type="OrthoDB" id="538961at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307897" evidence="1">
        <location>
            <begin position="32"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="37"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="42928" checksum="F7681DF5BA03B48D" modified="2011-06-28" version="1">MQRARAQLRHALAAVTATSLLAAGVACGSGAGDPDRVRIGLLVSLSGIYTSVGEDMRRGFQLYLDTHDGRLGGRDIDLVVADEGDGPATAVPAAQKLLERDRVVALTGLVGGATVDKVQTLTHERRIPLLGANARPEFAPVAGKPRDLSYTWHTSYNSDEPGIAIAAHIKTEVGDGTVYAIGPDYQGGWDELRGFTDTFTTLGGKLANPDGKTVFTPFPATENFLPYLNKAAETRPAAVYTFYAGGPAVAFVKQYRQSALKDVPLYAAGFLTEGSVLDAQGTAATGIRNVLNYSPTLPHAANQQFVAAWSAAGYPGQPTTFAMASYDAAAVLDRALAAVDGPVTGETLNTAIGQVGRIDSPRGDWQFHPTEHRPVQRWYLREVRPDGPVLSNVLLQDLTTLPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHE1</accession>
    <name>F4FHE1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lanthionine synthetase C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733768.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20055"/>
    <dbReference type="EnsemblBacteria" id="AEB45113">
        <property type="protein sequence ID" value="AEB45113"/>
        <property type="gene ID" value="VAB18032_20055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20055"/>
    <dbReference type="eggNOG" id="COG4403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285418_0_0_11"/>
    <dbReference type="OMA" id="WHEIEES"/>
    <dbReference type="OrthoDB" id="144841at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025410">
        <property type="entry name" value="Lant_dehyd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13575">
        <property type="entry name" value="DUF4135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4135" evidence="1">
        <location>
            <begin position="222"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1047" mass="112163" checksum="AB255909ADD9F8EA" modified="2011-06-28" version="1">MTTTSASLGLGAMSAPDTLLGLGGADERLLNVIALAAPFDEREAGVYFAPVRTGGRRKLAERSQRWLRSAVADDDVSLRALLLHRQQTNRDLGAGLVDVVVRDPGKLPDWAYALVDFLLAQPPTAAQDPAAELVGGVFVSFQRAAIRLTGLRQNNLRGVALTPEAADDVTGQLVQRLIKVCHAALGFELQIADGAATPVNWYGRAGIDVSRLGWLGRLESLPGLAYLIGVTCLNYKRAVGEIFDRLHQDLPMLRRELWAWADPGALASYSGDSGDLHDSGRTVSLLSFAGGQRVVYKPKDLSSVAGFMDVLTFLNTHGLPLDLTTRRVLLRDGYGWEEYVVARPCVSGEDPARFYRRLGMLTRLAQLLECRDLWADNLIAIGERPMFIDLENVLQGRMRKPVLLGPRAEALWHEIEESVAKTAVVSYPRIGVPGRRAHDIGCCAPMQEQLAVDSDGFPDGWEPPPYRPMVDGRYVDPAAHADDVLTGYREMDACLVANAPALAAERGPLHLLSQARVRYIWRSTWDYLTMLQVASGPLALTDGVAREIVLARLFRGAREVLHTDPRRTDSLEMIEREIEALRRLDIPLFQSEPMTSTVRTPEGSRVENHFSGTAWQRLRDRLDELVERAECGAPMPEEALAACLDFASGGRPIWAPPPGDPDGRRDPALLGISVYHPKAFRAEVDHSQLLAGACAAADDIIAAAVPVGDGQHGWVGAVHYPAFGLDQLEPLHGDLLTGTAGIAVFLAELYQTTGKPTYWAFAQDALAATTEFTTVAGQASLYRRMAGGRQPVGGFVGIGATIYALARCGQVIGDPQLLAQAQSLVPTARDLLAAGTSVADPVTGRAGLLLALLKLTEAQPCTAADELAASLYEQLLAELPGGVPAPYPAGVALLDALPSGAPGVAMALARYAERNGLSIDDEQLAPAVGSTSGALLAATVAAAALGRARPAQAQTPTPAGSPSSVDLLDRIELGLAAWRGDADEQQHTAAHAAARTLLSRRASQGRWFPDRRRADRTQLSAVDGLAAAGLACLALAEEDVTSLRTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHK1</accession>
    <name>F4FHK1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysine 2,3-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733828.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20365"/>
    <dbReference type="EnsemblBacteria" id="AEB45173">
        <property type="protein sequence ID" value="AEB45173"/>
        <property type="gene ID" value="VAB18032_20365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20365"/>
    <dbReference type="eggNOG" id="COG1509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032161_1_1_11"/>
    <dbReference type="OMA" id="GFMMPSF"/>
    <dbReference type="OrthoDB" id="557227at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="467" mass="53226" checksum="A07B6472E34B2FFA" modified="2011-06-28" version="1">MTQTHPPVQSTPAAQPAPANTTGQPYEYRRTPLVEPDWTRFPGWRHVTRDQWENAQWQRVNCVKNVKQLRTVLGDTVDESFYADLEADQRAMATMSMLVPPQMINTMVPFAPPSTEALLADPIRRYMIPVASDRRTDWPSHPYASRDSLHEHDMWVAEGLTHRYPTKVLAELLATCPQYCGHCTRMDLVGNSTPAVDKLKLSLKPVDRYDAHITYLKAHPGVRDVVVSGGDVANVPWRNLESYLMRLLEIETIRDIRLATKALMGLPQHWLQPDVVEGLERVARTAARRGVNLAIHTHVNHAQSLTPLVAKAAQTALDVGVRDVRNQGVLMRGVNATSKDLLDLCFGLQGEAGILPYYFYMCDMIPNAEHWRVPVWHAQQLQHDIMGYLPGYATPRIVCDVPFVGKRWVHMVTEYDRERGISYWTKNYRTSIESADLAALSKRYAYYDPIDTLPEAGQQWWQTHRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHP7</accession>
    <name>F4FHP7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 17" type="primary">hisD</name>
        <name evidence="17" type="ordered locus">VAB18032_26716</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 16">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735067.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26716"/>
    <dbReference type="EnsemblBacteria" id="AEB46416">
        <property type="protein sequence ID" value="AEB46416"/>
        <property type="gene ID" value="VAB18032_26716"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26716"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_1_11"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB46416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="439" mass="46040" checksum="6F0BC5A0BF4CFC6E" modified="2011-06-28" version="1">MLNRIDLRGGVSDPRDLLPRAQLDVSVAVEQIRPLVTAVREHGYSAVREASERFDGVAPEVLRVPVEAIAAAESTLDPQVRAALLEAIARVRKVHADQRRVDHTTTVVPGGTVTERWVPVDRVGLYVPGGLAMYPSTVVMNVVPAQEAGVRSLVVASPPQKDNDGLPDARVLAACALLGVDEVYAVGGAQAVAMLAYGCAVDAAGSAHCAPVDMITGPGNIWVTAAKRLLRGVVGIDAEAGPTEIAILADDSADPVHVAADLISQAEHDPLAASVLVTPSVALADAVDRELVRQVSATKHAERVDTALRGPQSGIVLVDDLAAGLRVVDAYAAEHLEIQTVDARQWAMRVRNAGAIFVGAYSPVSLGDYCAGSNHVLPTGGCARHSSGLSVQSFLRGIHLVEYTEAALREVAPHVVTLATVEDLPAHGQAVSLRFPEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHZ9</accession>
    <name>F4FHZ9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ordered locus">VAB18032_03040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736324.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03040"/>
    <dbReference type="EnsemblBacteria" id="AEB47692">
        <property type="protein sequence ID" value="AEB47692"/>
        <property type="gene ID" value="VAB18032_03040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03040"/>
    <dbReference type="eggNOG" id="ENOG5032TCV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106245_2_4_11"/>
    <dbReference type="OMA" id="FAAQRKH"/>
    <dbReference type="OrthoDB" id="1929976at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="110" mass="12270" checksum="B5325A27718E7FA9" modified="2011-06-28" version="1">MGMITDWPSLAACQNGDPDALFVQGAEQNVAKRICRSCPVRYECLADALDNRIEFGVWGGMTERERRALLRRHPQVASWRKMFEAAMKKNAKDKSGKDKILVTTGAVGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI53</accession>
    <name>F4FI53_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30269"/>
    <dbReference type="EnsemblBacteria" id="AEB48017">
        <property type="protein sequence ID" value="AEB48017"/>
        <property type="gene ID" value="VAB18032_30269"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30269"/>
    <dbReference type="eggNOG" id="ENOG5033DV7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1786096_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="145" mass="16027" checksum="F564E2B02F099838" modified="2011-06-28" version="1">MNRYGAQAQRHWQTFLPNRYAALIAEGTDLNSYFSTLGEQAAQLIEELARELAGPDPAGEGYLDKLGRLNEARMAAEEQVLPELILIDPETNETTPTATQGAAVETQTAPDDWIPMVEDPTDPRWQEIAEQEAAMNDDSEPPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F189</accession>
    <name>F4F189_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cmp/dcmp deaminase zinc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732592.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14065"/>
    <dbReference type="EnsemblBacteria" id="AEB43925">
        <property type="protein sequence ID" value="AEB43925"/>
        <property type="gene ID" value="VAB18032_14065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14065"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_4_1_11"/>
    <dbReference type="OMA" id="RYRNDWQ"/>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="13003" checksum="FFE3B448F5FFCB0D" modified="2011-06-28" version="1">MTMRDTDRALVQAASAVAKLRCRSAAHTLATVARTADGRVVSAVNVVHATGGACPEVVAIGTAVTQGVGELETIVTVGDRGRSLVTPCDACRQLLGDLFPSLRVIIGPLDTPRVVPITDLPPATPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1D7</accession>
    <name>F4F1D7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chab family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732640.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14305"/>
    <dbReference type="EnsemblBacteria" id="AEB43973">
        <property type="protein sequence ID" value="AEB43973"/>
        <property type="gene ID" value="VAB18032_14305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14305"/>
    <dbReference type="eggNOG" id="COG4572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129869_0_0_11"/>
    <dbReference type="OMA" id="HTHEKVG"/>
    <dbReference type="OrthoDB" id="1882650at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009317">
        <property type="entry name" value="ChaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037205">
        <property type="entry name" value="ChaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06150">
        <property type="entry name" value="ChaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140376">
        <property type="entry name" value="SSF140376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="133" mass="14627" checksum="A984D9B2B2225427" modified="2011-06-28" version="1">MPGREVLPSTLRRSPEKAQRTWEKTHDSAVETYGEGERAHRTAFAAVKHQFEKVGDHWEPKGRKGPSDAQAAGGGPQRRAPTAGGVDANAPKDHLLEVARKLDVRGRSSMTKPELVKAIEKANDRQTRKARGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1F7</accession>
    <name>F4F1F7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733840.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20430"/>
    <dbReference type="EnsemblBacteria" id="AEB45186">
        <property type="protein sequence ID" value="AEB45186"/>
        <property type="gene ID" value="VAB18032_20430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20430"/>
    <dbReference type="eggNOG" id="ENOG503303C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737490_0_0_11"/>
    <dbReference type="OMA" id="RYCRDND"/>
    <dbReference type="OrthoDB" id="1766313at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="406" mass="43365" checksum="C1687D3E946E10AC" modified="2011-06-28" version="1">MDAEPATDTRPCAHCGADVPQRAGAGRPFRYCRDNDGACQRASRNSRMRHRNAPGLPGQVARTWEAVDRLDQIVQTLTEALHAELSPAGVERQLAQIRAETAGAVAAAQTERDEAVRAAEDAAARAERDRRQAQAATAERDAARVDADRAAQQAAAADARAEQAQTDRDEARRAAVAAEALRAQAQTDLDDVRAQVAATRTDLDAERRRTATLVAERDTARAEAHRADRVAAEATARIEALHAEVEQVRRQEQQVRAELAQARTDAEQATTRLAAVRVDLDQAQQARAQAEADRQRAQATARQVGGDLAAAIADTDSLRVDLAAAVALADTLRADLAAAVALADTLRADLAAVREAAAAADSRIGELTQRLRVAESDRDDARERVAQLAGQVAELATALTRRAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1H7</accession>
    <name>F4F1H7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733860.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20530"/>
    <dbReference type="EnsemblBacteria" id="AEB45206">
        <property type="protein sequence ID" value="AEB45206"/>
        <property type="gene ID" value="VAB18032_20530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20530"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="VHARGMT"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="232" mass="24788" checksum="4A903F6316464406" modified="2011-06-28" version="1">MSEDLVRVQGLCRDYGSGDRVVHALRDVSLRAGRGELVAVRGRSGAGKTTLLNLIGGLDRPTAGRVWVAGHEVTAAGERDLLRLRRDDIGFVFQSFGLIPILSAAENVGVPMRLAKVPAAQREERVSVLLELVGLGGHAAQRPYEMSGGQQQRVAIARALANDPALLIADEPTGQLDSETGRAVMDLLRALVHARGMTALVATHDPTLMELADRVLVLRDGRLVESSEPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1K0</accession>
    <name>F4F1K0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733883.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20645"/>
    <dbReference type="EnsemblBacteria" id="AEB45229">
        <property type="protein sequence ID" value="AEB45229"/>
        <property type="gene ID" value="VAB18032_20645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20645"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_11"/>
    <dbReference type="OMA" id="SFERICI"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="2"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="474" mass="50345" checksum="B13DAA29EF68238D" modified="2011-06-28" version="1">MVDVVSPIDAQVLARVAPTAPADVDAAVRAARAAQPAWARRTGSERARVLHAIADLIEARVEDLAETETRNTGKILSDTRREVRRAAGSFRYYAGWAEQVRGETIPVGPEYHTYTVPEPHGVVAGVIPWNVPFFFAAKKIAPALAFGNACLLKPAEETPLTALRLGELLAEAGIPQGLVQVLPGGRETGAALVSHPGVDLIVFTGHHDTGKAIARAAAANLTPIALELGGKSPQVVFPDADLDRAVDAVVLGVFASCGQMCIAGSRLVLHESIYDEVLDRVAARVRTLQVGDPFDERTDLGPQITAAQRDKTVAFIAETRNAGRLVAQAALPDDERLRDGFYVPPTVFDRLDEGARVLREEVFGPVLAVSSFRDDAEALRLADDTQFGLAAGVWTADIARAHRFAGQVRAGTVWINTYRVLSDLVPFGGVGLSGYGRENGTEAARLYLRPKSVWTSLAGGIPQGYGMGGAGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1W0</accession>
    <name>F4F1W0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AzlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_27311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27311"/>
    <dbReference type="EnsemblBacteria" id="AEB46535">
        <property type="protein sequence ID" value="AEB46535"/>
        <property type="gene ID" value="VAB18032_27311"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27311"/>
    <dbReference type="eggNOG" id="COG1296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065777_0_1_11"/>
    <dbReference type="OMA" id="DFAFPAV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="241" mass="24250" checksum="92D73B71DF753E7F" modified="2011-06-28" version="1">MLRDVAAIGAAIVAVGASFGAVAVAAGLPVWAVVAMSLFVYAGGAQFMAVGLAAAGNPMAAVLAGLLLNARHLPFGLTLGDSLGRRLWQRLLGSHLMTDEATAFALARPAGEVRHRAFWLAGTLLFVAWNAGTVLGVLAGGVAGDPATLGLDAAFPAGLIALLLPTLRDPDTRRAALGGAVLAVLTTPVLPAGLPVLLALAGPALLAVHRLRRPPAAPTAQVVEPADEAHAVPVGRKESSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Z4</accession>
    <name>F4F1Z4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_03285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736373.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03285"/>
    <dbReference type="EnsemblBacteria" id="AEB47741">
        <property type="protein sequence ID" value="AEB47741"/>
        <property type="gene ID" value="VAB18032_03285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03285"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="WLDHQPL"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="24778" checksum="2481DAC0E3FBEA3D" modified="2011-06-28" version="1">MLTLESVKGWYGSTQALFGVNLRVPPGKTVALVGTNGAGKTTTLRAILGAVRTEGSVRVDDVDISAKPTHRRVNDHHISVVHEGRGLLSQLSVLENLTVGANRAQRARIDEVLDLFPALQGRTHQKVSLLSGGQQQMVALGRALLRDPKYLLLDEPGLGLAPVVIDEIYRYIAELCSRGMGVLLVEQSVARAASVADELVLLRVGTVDRVIDTADSAQVDQLVADAFGVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F274</accession>
    <name>F4F274_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_08225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731434.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08225"/>
    <dbReference type="EnsemblBacteria" id="AEB42763">
        <property type="protein sequence ID" value="AEB42763"/>
        <property type="gene ID" value="VAB18032_08225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08225"/>
    <dbReference type="eggNOG" id="COG2095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_0_0_11"/>
    <dbReference type="OMA" id="LFVIMDP"/>
    <dbReference type="OrthoDB" id="1323133at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="21189" checksum="990A7CB92382D085" modified="2011-06-28" version="1">MDLKLFGEVFVTLLVIVDPPGMMPIFLALTSPLAARERNRAAWQAVALALGVIVVFAVAGQTLLAYLHVDLPALQAAGGLLLVLVALELLTGKTDDPTKQATSNIALVPLGTPLLAGPGAIVATMLFVQQADVAADYVAIATAIVAVMLTVWIVLRFSGGIVKVLRPGGIEVLTRIAGLLLAAIAVQLIADAIFAFVADFTATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2B5</accession>
    <name>F4F2B5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">VAB18032_08430</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08430"/>
    <dbReference type="EnsemblBacteria" id="AEB42804">
        <property type="protein sequence ID" value="AEB42804"/>
        <property type="gene ID" value="VAB18032_08430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08430"/>
    <dbReference type="eggNOG" id="COG1928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021079_0_0_11"/>
    <dbReference type="OMA" id="AGNHHPW"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="14">
        <location>
            <begin position="67"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="15">
        <location>
            <begin position="368"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB42804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="572" mass="62868" checksum="C73CCACCBB70D777" modified="2011-06-28" version="1">MAAYDRRVTSASTAHSASADQPQPDAGSATTGSTDRTDSGVPAMVRRRLATVETRLDSRSWLATAVVVAIAAILRFANLSHPPGKIFDEIYYARDAWALVDKGVEWNYKDGGPSYVVHPPLGKWLIGLGEWAFGYSDAEHGISVPGQLFTTAPEFGWRFSAALIGTLSVLLLIRIGRRLFGSTVLGCAAGLLLAVDGYHLVLSRTALLDIFLLFFVLAAFGALVLDRDATRRRWARALEAGLDPTLRGRAGRPPGGWRNWPWWRLATGVLLGCAFAVKWSALFFVPVFALLMLLWDVGARRSAGVPRPWRATMLDGFPWMVLAGVLMAVTYVVSWSGWLLSNEGYYRLAERYPQAGLSDTPIIGPLWNLVQYHQAALGFHSQLDDPHKYQSWPWQWLLLGRPVAFHWVQPQGGCGAAAGCAEEILLLGTPLLWWSFLPALVALIWLGLARRDWRAGAILLLVAAALLPWFWFALDGRTMFFFYAAPAVPFLVLAVVYVLGAIASPAGMSGTLPVDGADAEASRDRRMIGAVIAGAYVALVVICFAYFYPIFVGLNIPYAEWSARMWLGDRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2E7</accession>
    <name>F4F2E7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732686.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14535"/>
    <dbReference type="EnsemblBacteria" id="AEB44019">
        <property type="protein sequence ID" value="AEB44019"/>
        <property type="gene ID" value="VAB18032_14535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14535"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098191_1_0_11"/>
    <dbReference type="OMA" id="WFRLAGH"/>
    <dbReference type="OrthoDB" id="1975541at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="168" mass="18822" checksum="BDAE0B3AEF05ED29" modified="2011-06-28" version="1">MPGMWWVVGATVVVGLVAAYLIWTAGRVERLQARAQLAARALDAHLLRRAAAAAVLAERRYGVELYAAARIALDAQPEEREAAENDLTRQLRAVELDPTDPDCEAVIAASRRLALARQVHTDLVRDARTARSRRLVRLFRMGRRHTWPRYFDIDDPTLTTPAADVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2F7</accession>
    <name>F4F2F7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14585"/>
    <dbReference type="EnsemblBacteria" id="AEB44029">
        <property type="protein sequence ID" value="AEB44029"/>
        <property type="gene ID" value="VAB18032_14585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14585"/>
    <dbReference type="eggNOG" id="ENOG5030417">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299284_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="88"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="23457" checksum="574ED11656F8D4EB" modified="2011-06-28" version="1">MLLRVEYGADRVGLSVYLAGMLFDATGDLLRHTGGPLPAPEELFDRFLAWTAPQPRARHRAAVSQPGGRTPGTTCPRSMIMDVRDAAQRWADAWAHGWPAKDVESIVTLQATDGVHWASLFRPCRGRDGLRAYVEECFGEETRPAEVWFAAPRCDGATATVEYWAITYPYDAPLTISGCTLLRFDADALVAESRDYSHTREGRFPPPAGIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2K3</accession>
    <name>F4F2K3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine phosphatase with gaf(S) sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733922.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20840"/>
    <dbReference type="EnsemblBacteria" id="AEB45268">
        <property type="protein sequence ID" value="AEB45268"/>
        <property type="gene ID" value="VAB18032_20840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20840"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043255_0_0_11"/>
    <dbReference type="OMA" id="NAMRNAR"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="168"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="392" mass="42918" checksum="33CE84C6220FC712" modified="2011-06-28" version="1">MADALTGISRALREAPPDRVVEAADQAIRSVLGAVGTAVFVADYRINGLWPVLDSRQPQVAGQAVQSMVQRCFSSQQWVRGGEPQGRCRLYLPLTVWGERLGVLMVELPQAPSEEVVAAATDIAGEVAMALRAADRETDRYRRARRRERLSMAAELQWELLPGRGISHEAFQLAGQLEPAYTVSGDHFDWSLNDDRLTVTVLNGDTIGLAAALLTAVTVNAMRNARRSGGGLVEQAELASDTVYYQHRGHRHVATVLLELDCTTGRVRAVDAGSPHLMRLRGGAVTRLVLEQQLPLGMFAETRYNLQEFDLDPGDRLFVVSDGVWGADPSGREAYGQRAMARSMRATRLQPPSEAVGTVMRELQAFHADADLRDDAVVVCLDWHGGGERADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2X3</accession>
    <name>F4F2X3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_27556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735234.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27556"/>
    <dbReference type="EnsemblBacteria" id="AEB46584">
        <property type="protein sequence ID" value="AEB46584"/>
        <property type="gene ID" value="VAB18032_27556"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27556"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_7_3_11"/>
    <dbReference type="OMA" id="GEQPAAC"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="169" mass="18461" checksum="E741156C661819C8" modified="2011-06-28" version="1">MGVPDYILRMRKHVGHDLLWLPSVSAVVRNEAGELLLGQRADDGRWAVVSGFVEPGEQPATAVVREVLEETGLAVEPLRLSSAVSHPHRYPNGDLCEYLNLGFHCRLLGGQARVNDDESLAVGWFPPGRLPELDEHSRLVIRHALGPEAVAFFLPPGTLWGEPGEPAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F346</accession>
    <name>F4F346_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03715"/>
    <dbReference type="EnsemblBacteria" id="AEB47825">
        <property type="protein sequence ID" value="AEB47825"/>
        <property type="gene ID" value="VAB18032_03715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03715"/>
    <dbReference type="eggNOG" id="ENOG5033JRT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066207_0_0_11"/>
    <dbReference type="OMA" id="SWHRAAY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="293" mass="29808" checksum="586BA881E33B6203" modified="2011-06-28" version="1">MPPSTTVEDADVTGTSAAKKAPARRAASAKAAPQPLAAKKTPARKAAAQQTTPTTTAAEPVLTSSTTADRAGDAGSSTGGVPEVELRALVARVLDHPGFAPELLALTAVEVLGPRAAQWARRLRETYPEASADGLARLAGQRFVRQATVGGAGAALAGAFAPVVELAVVLWSQASLVLHLAAAYGRDPAHPDRAAELLVLTLVHPDLEAARSALAAARAADGPGEEPGPRAVEAAWRLAAPLTAQAGGWLVLRLASRLIPGAAPLAAAVTTSTATQRLTARALTAYRPPRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3L8</accession>
    <name>F4F3L8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fmu (Sun) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_15070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15070"/>
    <dbReference type="EnsemblBacteria" id="AEB44126">
        <property type="protein sequence ID" value="AEB44126"/>
        <property type="gene ID" value="VAB18032_15070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15070"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_3_11"/>
    <dbReference type="OMA" id="RVNRQHH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="7">
        <location>
            <begin position="161"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="263"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="450" mass="47521" checksum="74647937F2C4CCD4" modified="2011-06-28" version="1">MDRPRYAAYQAVAAVNRDDAYANLVLPSILREEGLFGRDAAFATELTYGTLRHSGTLDAILTSAAGRDVQRIDPPVRDALRIGAYQLLHTRVPAHAAVSSTVDLVRMVGQGATGFANAVLREVAACDLDTWVSRLAPSMETDPIGHLALAHSHPQWIVRAFSEALDGDLGETTRLLIENNERPPVHLCARPGLADPVELADASGGAPGAFSPYAVYLGGGAPGDVAAVADGRAHVQDEGSQLVANALAVAPIDGPDGRWLDLCAGPGGKAGLLGALAAQRDARVTAVEVAEHRARLVEGATRGLPVTVLHTDGRLVGAEPKLPEGHFDRVLVDAPCTGLGSLRRRPESRWRRQPSDLPALTRLQRELLTAGLRAVRPGGVVAYVTCSPHTVETHVTVTEAARRSGASVDFVDARPLLPAGMPGLGDGPTVQLWPHRHGTDAMFLAVLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3P1</accession>
    <name>F4F3P1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_15185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15185"/>
    <dbReference type="EnsemblBacteria" id="AEB44149">
        <property type="protein sequence ID" value="AEB44149"/>
        <property type="gene ID" value="VAB18032_15185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15185"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_0_11"/>
    <dbReference type="OMA" id="CHCEGCP"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="74"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="208"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="32671" checksum="72D6B7064849FCF9" modified="2011-06-28" version="1">MWSVPIDVLLELGLDLHLTLGLLLAYLLGVVLARRVRRIAAGRLRCGRCRRLSGVGAWMRREPTQNSQWPYGTFLQRLGPPVRSALLELGVRRQVPAGQILIHEGQQQSHLVLIEEGLTKVTAALPDGRTALLSLRVGGDLVGEMSALNDRPRSATVTTCSAARYSVIPSERFRAFLRTNPDAALELAAMVSDRLRWSNRRRIDFSSYPVKIRVARVIAELSRTHGRQTPDGVVIDVRLTQPELASICGASETSVQKILRELRTDGLVDTDYRRMTVRNLPGLQQVGQLQADEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3R7</accession>
    <name>F4F3R7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734021.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21340"/>
    <dbReference type="EnsemblBacteria" id="AEB45368">
        <property type="protein sequence ID" value="AEB45368"/>
        <property type="gene ID" value="VAB18032_21340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21340"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026437_2_1_11"/>
    <dbReference type="OMA" id="PGRWRWY"/>
    <dbReference type="OrthoDB" id="1834577at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="121"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="353" mass="37802" checksum="FB73309347B46604" modified="2011-06-28" version="1">MRDHPAAEVGGIAEAVFGRAAARFWDTVQEGCPGLLPEGDAPLILAGLLRLVGGGDDRPGRLALLTVLGRVYREHRLRPDHAALVGAALTVAVPSMPPEAATWRRAWRLVERAAARVGDGPASWPVEVLGRDRAGDTITILTVRPWRRLPFRPGDAMPVNVPQHPGRWRWYCPANAPRADGTMELHVRAVPGGDVSHRLAHQVRPGDLLRLGPPTPTGLALPDSPTPLLLVAGGTGLAPLRALVEQIAEAAAQPAITLVVGARTFVDLYDAIALDKLAQAHPWLRIVPALSHDPRAEPGEQGDALTVALDQLRPDQRVYVCGPPAMLAGSLLRLLAAGVPADRIHLPEQIPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3T4</accession>
    <name>F4F3T4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734038.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21425"/>
    <dbReference type="EnsemblBacteria" id="AEB45385">
        <property type="protein sequence ID" value="AEB45385"/>
        <property type="gene ID" value="VAB18032_21425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21425"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026719_1_0_11"/>
    <dbReference type="OMA" id="DGPSWLI"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="516" mass="58167" checksum="1414B310F83D1F9F" modified="2011-06-28" version="1">MGDEHGTVVIGAGPAGLTAAYELLRHGAPVRVFEADGVVGGISRTVERDGWRFDIGGHRFFTKVSRVEDFWHEILPDEDFLLRPRMSRIYYRGALYDYPLNAGNALRNLGLWEAARCMASYARARLRPPRDQSHFEGWVSARFGWRLYSIFFKTYTEKVWGMPADQLQADWAAQRIKNLSLAKAVRNAVLPKRNRTDVTSLIEEFQYPKLGPGMMWERCAEQVRRHGGTVQTGTWVTAVHRDPQQRRATSVTVDGVDGRRTEPADHVISSMPISELVAALRPAPPPQVLAAAEDLRYRDFLTVALVVPAEFSFPDNWIYVHDPDVKAGRIQNFGSWSPYLVKDGRTCLGLEYFVSVGDETWRTPDADLIVAAIRELETLGLVRPGVVEAGYVVRMPKAYPVYDERYQRNVDVIRQWLAREVPNVHPVGRNGMHRYNNQDHSMLTAMLTVENIVRDAGHDVWSVNVEQDYHEETSRGDGRHGTGRDAPLMPAPPLPAATTLAVEIPADVHRNTGVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3X8</accession>
    <name>F4F3X8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily mfs_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_27756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735274.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27756"/>
    <dbReference type="EnsemblBacteria" id="AEB46624">
        <property type="protein sequence ID" value="AEB46624"/>
        <property type="gene ID" value="VAB18032_27756"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040011_1_1_11"/>
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    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="240"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="423" mass="44116" checksum="72FE0A3619D56D25" modified="2011-06-28" version="1">MTTVDPMPASLPAALAEPTVPVRRGWIALLFAANLGVWMAFFTPIQVLLPQQIEQIAPTDKETMLAVVTGVGALAAVLANPLAGALSDRTCLRLGRWELGRRHVWTVGGALIGALALVLLAQARTVAAVTVGWVAAQVCFNAMLASLTAAVPDRVPVAQRGGVSGWVGIPQALGLVLGVVLVTAVVTGNAAGYYAIAAAVVLLAVPFALRTTDDPLPRTHRPALRGMLAGMWVSPRRHPDFGWAWITRFLVQLGNAFGTLYLLYFLTDEVRLADPDTGLLVLILLYTAGLMATTVIAGRLSDRSGRRKVFVIAAGMVMAVAALLLAAAPTWPTAIVAALLLGAGYGVYLSVDAALITQVLPRATDRAKDLGVINIANSAPQVLGPAIAAPIVVYLGGYPALYATTAAVTVLGSVLVLKIRSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F420</accession>
    <name>F4F420_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, GntR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27966"/>
    <dbReference type="EnsemblBacteria" id="AEB46666">
        <property type="protein sequence ID" value="AEB46666"/>
        <property type="gene ID" value="VAB18032_27966"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27966"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_0_11"/>
    <dbReference type="OMA" id="INHLTVM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="128" mass="14167" checksum="76147FAC74FB6A4A" modified="2011-06-28" version="1">MERSGAAGVMDDGRPIFQQIAELLESSILDGTLAEESQVPSTNELAAFHRINPATAAKGVNKLVDDGTLYKKRGIGMFVSSGARAKLRARRRDEFARQYVQPLVAEARKLGIDPAELKHMIDNWEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F437</accession>
    <name>F4F437_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735333.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28051"/>
    <dbReference type="EnsemblBacteria" id="AEB46683">
        <property type="protein sequence ID" value="AEB46683"/>
        <property type="gene ID" value="VAB18032_28051"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28051"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061796_1_0_11"/>
    <dbReference type="OMA" id="VDCKEAR"/>
    <dbReference type="OrthoDB" id="1169054at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="335" mass="37844" checksum="A9E7920D1C6D36E5" modified="2011-06-28" version="1">MARPITLFTGQWADLPFDEVCRLAAEWGYDGLELACWGDHFEVDKALADDSYIERKRETLAKHNLQVFTISNHLVGQAVCDHPIDERHQGILPARIWGDGEPEGVRQRAAEEIKDTARAAAKLGVNTVVGFTGSSIWHTLAMFPPVPPSMIERGYQDFADRWNPILDVFDSVGVRFAHEVHPSEIAYDYYTTKRTLEAIDHRPAFGLNWDPSHFVWQELDPVNFIFDFADRIYHVDCKDAKVRTGDGRRGRLASHLPWADLRRGWDFVSTGHGDVPWEDCFRALNAIGYDGPISIEWEDAGMDRLVGAPEALQFVRRLAFDAPSAAFDAAFSSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F449</accession>
    <name>F4F449_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_28121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735345.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28121"/>
    <dbReference type="EnsemblBacteria" id="AEB46695">
        <property type="protein sequence ID" value="AEB46695"/>
        <property type="gene ID" value="VAB18032_28121"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28121"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_2_11"/>
    <dbReference type="OMA" id="NVHLGHE"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="272"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="522" mass="55947" checksum="064C9D63AD70A3F8" modified="2011-06-28" version="1">MSETGRPLVEAPADAVAGEVVLRLSDVVKTFPGVRALDGVQLEVRAGEVHCLLGQNGAGKSTLIKVLAGVHRPDSGLVEWRGQPVSFANPQAAMRAGIATIYQELDLVEDLSVAENAFLGHEPRSLGFIRRGHMARRTRQILGRLGHAEIPPGRMVRALPAAGKQVVSMARALSHEARLIIMDEPSAVLAHDEVENLFRIIRELTAQGIAVIYISHRLEEIREIGDRVTVLKDGRTTAANLPARDTPTRDLVSRMTGRTIEYVFPEPSADTTVGEKLLEVDGLTRSGEFADVSLTVAAGEIVGIAGLVGSGRSEVLETIYGARRAESGTVRMAGKALRPGSVGAAVRAGLGMAPEERKSQALLLGEPIYRNVTLATFARYARLGFTDIGKERAEADRIAESLEMRPRDVNRPVRTLSGGNQQKVVVGRWLLGGTRLLLLDEPTRGVDVGARAELYQVIRELAAQGVGVLLVSSEVPEVLGLADRVLVMREGRVVRTAPAAELDESTVLDLVMSGSLMEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F469</accession>
    <name>F4F469_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47882">
        <property type="protein sequence ID" value="AEB47882"/>
        <property type="gene ID" value="VAB18032_04000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04000"/>
    <dbReference type="eggNOG" id="COG2852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2686793_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="74" mass="8471" checksum="E3940A14871AC689" modified="2011-06-28" version="1">MAIEYDGLWHDDPAQFDADRRRLKPVVGGDWIVLHLTAKRLREDFDGFVAEVRAALRSRGHRNGAPRIPEQHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4B4</accession>
    <name>F4F4B4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736559.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04225"/>
    <dbReference type="EnsemblBacteria" id="AEB47927">
        <property type="protein sequence ID" value="AEB47927"/>
        <property type="gene ID" value="VAB18032_04225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04225"/>
    <dbReference type="HOGENOM" id="CLU_179261_0_0_11"/>
    <dbReference type="OrthoDB" id="1932887at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="85" mass="9891" checksum="A56E50FC6534ADC5" modified="2011-06-28" version="1">MSPGVYLLNRDASPQFHVPILVRVIRELTDRHPPYGWTWIDCYQLDRHGDATEKRQLFVMPEGIRPVRVAPVPYPARRAPARTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4D6</accession>
    <name>F4F4D6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caffeoyl-CoA O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731565.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08880"/>
    <dbReference type="EnsemblBacteria" id="AEB42894">
        <property type="protein sequence ID" value="AEB42894"/>
        <property type="gene ID" value="VAB18032_08880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08880"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_5_1_11"/>
    <dbReference type="OMA" id="SVARRYW"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="23613" checksum="24F28050A632F7FD" modified="2011-06-28" version="1">MTLKSIPLTDELHGYLVAHGAPPDEVIRDLAEETLALLPEHASMQVAPEQAAFLTFLTRLLGARQAVEVGTFTGLSALAIARGLVDGGRLTCFDISEEYTSVARRYWARAGVADLIDLRIGPAGDTLRQLPNERYLDFAFIDADKTGYPIYWAELVPRMRPGGVIAVDNVLRHGRVIAPQNADDRAIAAFNDDVLADVRVDAVMLPIADGLTLARVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4M0</accession>
    <name>F4F4M0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="8" type="ordered locus">VAB18032_15250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732827.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15250"/>
    <dbReference type="EnsemblBacteria" id="AEB44162">
        <property type="protein sequence ID" value="AEB44162"/>
        <property type="gene ID" value="VAB18032_15250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15250"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_11"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="OrthoDB" id="751464at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="31"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="487" mass="52110" checksum="E10A16A5212C038A" modified="2011-06-28" version="1">MGGVDDKTLTENSTAANRTSLWGGRFAGGPSEALARLSVSVQFDWRLAPYDIAGSRAHARVLAGAGLLDPEELGRILAALDDLEAACASGAFRPTVDDEDVHTALERGLLERLGSLGGKLRAGRSRNDQVATDLRLYLRDHARGVASRLVELAEALVEQAERHVDTAAPGMTHLQHAQPVTFGHWLLAHVQPLLRDLERLRDWDHRAAVSPLGAGALAGSGLPLDPVAVSKELGFRTSFANSMDAVADRDFVAEFLFITAMIGVHLSRLGEEVVLWTSQEFGWVELDDAFATGSSIMPQKKNADIAELARGKSGRLVGGLVAVLTMLKGLPMTYDRDMQEDKEPAFDAVDTLELLLPALAGMISTMTVRVDRLVAAAPVGFSLATEVADWLVRKGVPFRDAHEITGKLVALCAARDCALDEVSDDDLATVSEHLDPSVRDVLSVRSALAARITPGSTGPGPVADQLAAAADHLATWREWAAETVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4R8</accession>
    <name>F4F4R8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732875.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15490"/>
    <dbReference type="EnsemblBacteria" id="AEB44210">
        <property type="protein sequence ID" value="AEB44210"/>
        <property type="gene ID" value="VAB18032_15490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15490"/>
    <dbReference type="eggNOG" id="ENOG5032KMF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186827_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="8255" checksum="4B4E9FC90088B3D5" modified="2011-06-28" version="1">MNLAAVALTALAVGTILGITLGIPLGRRVERVAWHAEAAIGRARVTGWLIRDLTSLALTTAAVVAVAAFVLWALLRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F524</accession>
    <name>F4F524_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735356.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28176"/>
    <dbReference type="EnsemblBacteria" id="AEB46706">
        <property type="protein sequence ID" value="AEB46706"/>
        <property type="gene ID" value="VAB18032_28176"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28176"/>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099864_1_0_11"/>
    <dbReference type="OMA" id="IEMPNDP"/>
    <dbReference type="OrthoDB" id="1441395at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307423" description="Peptidase_C39_2 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="52"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="22706" checksum="D2C11DA81BFE44BB" modified="2011-06-28" version="1">MRTTMLRKTALTIAAAAATAGGIAGPAIAAQAAPGTPTAVQADRKPGGERQLDVRYEAQPNFYYCGPAAARNALSVQGKNIDVHTMAKEMGTTEAGTDSINDITPVLNKETGKDVYRSVEIPGAKADDKQTDKLREDIKRTVDSGHAVVANIAGTTTDTDGVVHSFEGGHYISVTGYQDDGDTVTIADSANPATATYQLTIDDLADWIATRGYTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F4F547</accession>
    <name>F4F547_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_28291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735379.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28291"/>
    <dbReference type="EnsemblBacteria" id="AEB46729">
        <property type="protein sequence ID" value="AEB46729"/>
        <property type="gene ID" value="VAB18032_28291"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28291"/>
    <dbReference type="eggNOG" id="COG0362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_11"/>
    <dbReference type="OMA" id="VIMVKAG"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="182"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="481" mass="52101" checksum="4C435B43D6BD3ADA" modified="2011-06-28" version="1">MADRATAQIGVTGLAVMGRNLARNLARNGFTVALHNRSPERTRSLVAEHGDEGTFVPTESLADFVAALERPRAVIIMVKAGGPTDAVIDELVPLLEAGDIIIDCGNAHFADTRRREEALRAHGLHFVGTGVSGGEEGALWGPSIMPGGSVESYRKLGPIFEKIAAQVDGEPCCQHVGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRAGLGATPSELAEIFREWNTGELESFLIEITADVLAHTDAATGEAFVDVVQDRAEQKGTGRWTVQIALDLGIPITGIAEATFARSLSGHVGQREAAVRAFPDSGEKWQVTDREAFIEDVRRALLASKIVAYAQGFDQIRAGSAEYDWNIDLGGTARIWRGGCIIRARFLDRIKQAYDEQPELPTLLVAPWFADTVRDGVPSWRRVVAEAAQAGVPTPAFASSLAYFDALRAERLPAALIQGLRDNFGAHTYRRVDRDGSFHTLWATPDRAEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5A3</accession>
    <name>F4F5A3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator PadR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736582.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04345"/>
    <dbReference type="EnsemblBacteria" id="AEB47951">
        <property type="protein sequence ID" value="AEB47951"/>
        <property type="gene ID" value="VAB18032_04345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04345"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_3_0_11"/>
    <dbReference type="OMA" id="APMHGYE"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="23672" checksum="F65AF2F6035A7C24" modified="2011-06-28" version="1">MLELAILGLLQEAPMHGYELRKELTAKLGAIRAAISYGSLYPTLRRLQAAGWITEAADTPATAEEVPALTSRRGRVVYTITAEGKERFAQLIAQTGPETYGDTGFGVHFAFFSRTDQATRLRILEGRRRTIEERREGLRDMLGRAAERLDAYTLELQRHGLEACEREVRWLEELIANERSGRAPTVPNDGTAGGRREDNSPPPPGESRKERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5E0</accession>
    <name>F4F5E0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42972">
        <property type="protein sequence ID" value="AEB42972"/>
        <property type="gene ID" value="VAB18032_09270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09270"/>
    <dbReference type="eggNOG" id="ENOG502ZUG8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161236_0_0_11"/>
    <dbReference type="OMA" id="QPRWAAS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="97" mass="10382" checksum="571C144A763A862C" modified="2011-06-28" version="1">MELLVRQVGHWQQGRWSGVASASELPRADLVYRLIQDIADLSADAEGQPRRVVPRLDNDLALADQLRVVAADLLAAGPADDVLARATAEVAATRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5E5</accession>
    <name>F4F5E5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Beta-thionase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Serine sulfhydrase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_09295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homocysteine + L-serine = H2O + L,L-cystathionine</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731648.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09295"/>
    <dbReference type="EnsemblBacteria" id="AEB42977">
        <property type="protein sequence ID" value="AEB42977"/>
        <property type="gene ID" value="VAB18032_09295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09295"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_0_0_11"/>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="336"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB42977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="456" mass="48529" checksum="6BACA09DB669CF1A" modified="2011-06-28" version="1">MQYYDNVVELIGNTPLVRLRNVAEGIQATVLAKVEYLNPGGSVKDRIALRMVEDAEAAGILKPGGTIVEPTSGNTGVGLALVAQLKGYKCVFVCPDKVSQDKQDVLRAYGAEVVVCPTAVAPEDPRSYYNVSDRLAREIPGAWKPNQYANPANPRSHYEVTGPELWKQTEGRITHFVAGVGTGGTISGIGRYLKEASGGTVKVIGADPEGSVYSGGTGRPYLVEGVGEDFWPETYDRSVADEIIEVSDKQSFEMTRRLAREEGLLVGGSCGMAAVAALEVARSAGPDDVVVVLLPDGGRGYLSKIFNDTWMARYGFLDNSGSEPTVAEALAGKPGGLPELVHVHPTETVRDAVDYMREYGVSQLPVLKAEPPVVTGEVAGSIAERDLLDALFTGQAQLHDTIERHMAPPLPMVGGGQPVSEAVNLLEKSDAALVLIDGKPKGVLTRQDLLAHLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5G9</accession>
    <name>F4F5G9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_09415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731672.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09415"/>
    <dbReference type="EnsemblBacteria" id="AEB43001">
        <property type="protein sequence ID" value="AEB43001"/>
        <property type="gene ID" value="VAB18032_09415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09415"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_11"/>
    <dbReference type="OMA" id="NMATWML"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="387" mass="41529" checksum="114B9F26DB29591E" modified="2011-06-28" version="1">MAAEQSFDAYRLPEEHEAIREAVREVCAAKVAPHAAEADETGEFPKASYDALRAADFHAPHIPVEYGGAGADALATAIVIEEVARACASSSLIPAVNKLGTMPLLLAGSEELKRRYLPPVASGEAMFSYCLSEPEAGSDAASMTTRAVRDGDHWVLNGVKRWITNAGVSEFYTVFAVTDPAARSRGISAFVVEKSDPGVSFGAPEKKLGIKGSPTREVYLDNVRIPADRMIGAEGTGFATAMQTLDHTRVTIAAQAVGIAQGALDYAKGYVAERKQFGKAVAEFQGVQFMLADMGMKLEAARQLTYAAAGRSERGDADLTYFGAAAKCFASDAAMEITTDAVQLLGGYGYTRDYPVERMMRDAKITQIYEGTNQVQRIVMARQLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5K2</accession>
    <name>F4F5K2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_09580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731705.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09580"/>
    <dbReference type="EnsemblBacteria" id="AEB43034">
        <property type="protein sequence ID" value="AEB43034"/>
        <property type="gene ID" value="VAB18032_09580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09580"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_11"/>
    <dbReference type="OMA" id="YNMSHEL"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="142"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="352" mass="37685" checksum="9BA0475E95138608" modified="2011-06-28" version="1">MTPRRRILVVGAAALIVGIAMPLVVKRVLNLVWVFGQRLCDAGLPGVRTACGAAGSVVGQLSMLTGLVVLVIALVGIWVAGAWCLRPVSDLAGPIAHVGPQNLGHRIRPRGNDEMARLARAIDDMMERIAAGYEGQRRFAANASHELRTPLAVQRTLIEVGMARSLTGEQLELLTSQLLETNERNERLIEGLLALSESDQGLRARLPQRLDEIVGTVLAGYQERAEEAGVTVQSHLSPRVVMGERVLLERLVSNLVENAIKYNRPGGTLTVTVGREPALTVVNSGQVVPAEAVAGLFEPFRRLARDRTNHSGGAGLGLAIARSITQAHDGLIAARPAEYGGLRVDVQLPKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Y1</accession>
    <name>F4F5Y1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase FkbM family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734193.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22200"/>
    <dbReference type="EnsemblBacteria" id="AEB45540">
        <property type="protein sequence ID" value="AEB45540"/>
        <property type="gene ID" value="VAB18032_22200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22200"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063680_0_0_11"/>
    <dbReference type="OMA" id="EIFTERC"/>
    <dbReference type="OrthoDB" id="1340956at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="48"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="28699" checksum="E6307AD5A0683619" modified="2011-06-28" version="1">MERMRLPNGYDVMQLNAGETSLMYRNIVTGRAYLQHGVTLTPGGTVFDVGANVGVASLFFHWEAASRVFAFEPAPRCYQALAANFAEHRIRGAAYPFALSDRPGRAVLTNYPQITAMTSFHADRGYDEQLTRAFLANSGFDTDDIEEMVADRHDSETLTCELRTFSEVADELDGEPIDLLKINVEKAEVEVLRGIAERHWPTIRQVVVQLHDIGGRLHELRQELTERGYRVGVAQDPLLTGTDIFELFAVRPTGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F697</accession>
    <name>F4F697_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28891"/>
    <dbReference type="EnsemblBacteria" id="AEB46849">
        <property type="protein sequence ID" value="AEB46849"/>
        <property type="gene ID" value="VAB18032_28891"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28891"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_2_0_11"/>
    <dbReference type="OMA" id="HITIPGF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="200"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="456" mass="48346" checksum="C4A452062FDF33EC" modified="2011-06-28" version="1">MPVMTTPIMTEAELRAAVQRELPGVRADLERLVRIPGIAFEGFDHTHVERSAEAVAELLRGCGLDVEIVRAGGQPAVIGRRAAPPGAPTVMLYAHHDVQPVGDRALWQSDPFEPVERDGRLYGRGAADDKAGIMAHIAALRAFGDRLPVGVVLFIEGEEEYGSESLERLLAAHRDTIASDVIVVADSTNWDIGVPGLTTSLRGLVNCFVEVRTLEQAVHSGMFGGPVPDALTTLVRLLATLHDDAGNVAVDGLTQGVGATVDYPEERFRAEAGVLEGVQLIGTGRITDRIWTKPALAVLGIDSPATGEAPNALVPTAKAKLSVRLAPGDDPTKAYAALREHLHRHAPWGAQVEVSFEHDGAPCVIDSTGPMFDAARSAFRAAWDGTDAVDIGLGGSIPFIATLREMFPQAAILVTGVEDPHARAHGPNESLHLGEFARVCLAEALLLAKVAEVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6A3</accession>
    <name>F4F6A3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_09655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09655"/>
    <dbReference type="EnsemblBacteria" id="AEB43049">
        <property type="protein sequence ID" value="AEB43049"/>
        <property type="gene ID" value="VAB18032_09655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09655"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_9_2_11"/>
    <dbReference type="OMA" id="KCSQVMY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="163"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="276"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="386"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="462" mass="49116" checksum="F42D848B6214B174" modified="2011-06-28" version="1">MEPVSDLSQIVKAYDVRGTVPQQWDEGVAAALGSAFAQMLDATGDAGKAVLIGHDMRASGPALADAFAAGVRAEGRAVIEIGLASTDMIYYASGSLDLPGAMFTASHNPAQYNGIKMCHAGARPVGQDTGLAEVRERAQALLDKGEPVGEPTAPVHRQDLLADYAAHLRTLVDLSGIRPLTVVVDAGNGMAGHTVPSVLGDAALAALPLRIVPMYFELDGTFPNHEANPLDPANLVDLQRAVVAHGADIGLAFDGDADRCFVIDERGEPVSPSAITALVAARELAKHPGSTVIHNLITSQAVPEIIREHGGEPVVARVGHSFIKAEMARTNAIFGGEHSAHYYFRDFWFADTGMLAAMHTLAALGEQPQPLSVLAAEYERYVASGEINSTVTDQAAKVAEVRAAYPDAEVDELDGLTLRFPDGAWFNLRASNTEPLLRLNVEAPTAQRMTSLRDDVLDRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6B6</accession>
    <name>F4F6B6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731733.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09720"/>
    <dbReference type="EnsemblBacteria" id="AEB43062">
        <property type="protein sequence ID" value="AEB43062"/>
        <property type="gene ID" value="VAB18032_09720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09720"/>
    <dbReference type="eggNOG" id="ENOG5033ZG5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029084_0_0_11"/>
    <dbReference type="OMA" id="GTEPPFW"/>
    <dbReference type="OrthoDB" id="2047341at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="29411" checksum="5A4D6D2CA285603D" modified="2011-06-28" version="1">MPHAGSIAVLPNRPLTVGELLDSAVLLLRGHLGALLPLAGALALVEQLLLLPLRSAVGVDPPLWWTLSMSSLGPFLVLLAIGAATEAVIITLLGNPAARAAGNALVGRPTSMRDLLRPRGARWGATLLLCPVVGVTMLLASLPGPTWFLGFALLGGVAPALALDRLRPLRAPIRSVDLALRVGGRAAGLRLLGYLVWWLLRVGLAWGMFTGLSSLNLIAAGWAVAVAMLLWAAVNMVGYAGLACLDAVLHLETRIRTEGLDIHLSRAPVDAPRTTLLAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6C5</accession>
    <name>F4F6C5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AEB43071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="21163" checksum="120F1E11D8E38027" modified="2011-06-28" version="1">MRLRPAPAYDPPFVDESAGWPEPGDGQLALDLFSAHQRSARHASERPPHPRVTARPVPVRPGHDPVRQLPPGALATATPSATRVAHRFVANCIEVFNGFRPPVQLRRQLDPTRSAQLLPELARATARAVPTRRRTPRPTLRLRRLRVCELHPAAIEAAAVLTGVVDTNWAMALRLEHRRGTWLCTDLRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6J2</accession>
    <name>F4F6J2_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">VAB18032_16070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AEB44320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="30" mass="3227" checksum="837EF1882D476CA9" modified="2011-06-28" version="1">MARLEALRRSARNGHAGALIALGLRKPPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7K8</accession>
    <name>F4F7K8_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733106.1">
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    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16715"/>
    <dbReference type="EnsemblBacteria" id="AEB44447">
        <property type="protein sequence ID" value="AEB44447"/>
        <property type="gene ID" value="VAB18032_16715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16715"/>
    <dbReference type="eggNOG" id="ENOG5030Z5E">
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    <dbReference type="OMA" id="LPYAWEM"/>
    <dbReference type="OrthoDB" id="1690796at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="14277" checksum="F06EACD5A7086FE7" modified="2011-06-28" version="1">MSLAVPPSLLQAAEAGPVDDEAFVACVRDSLPYAWQVVSRVAADLESFDADFADNVVPPPTETERGQLLRALASDAIRSSLERHFGVKLAFQNCHRVAAFRLSAVDSDTYRRFVSVRGQLLNQSPELRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7R4</accession>
    <name>F4F7R4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">VAB18032_23005</name>
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    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45701">
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        <property type="gene ID" value="VAB18032_23005"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG50313PQ">
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    <dbReference type="OMA" id="VIDAPIW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="81" mass="8498" checksum="B32B7AAF2ABE3913" modified="2011-06-28" version="1">MDVVSMAGLRVKFYSFAALAAVGVVIDAPIWSIAAAAFLCAAIPLAVALQGTGRVRALFVPSRVAKMAAPQREVVRDAQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7U1</accession>
    <name>F4F7U1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
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                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="13762" checksum="5F211BE5D7B3D49B" modified="2011-06-28" version="1">MSEELDAETLEFAHRMFDLARDGATTELAGYVDAGLPVNLTNEKGDTLLILAAYHAHPATVAALLDRGADHTRTNDRGQTALAAAVFRSSGDAVRALLTAGADPDHGNPSAVETAQFFDLSEMLTLLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F825</accession>
    <name>F4F825_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Sua5/ycio/yrdc/ywlc family protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735648.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29646"/>
    <dbReference type="EnsemblBacteria" id="AEB47000">
        <property type="protein sequence ID" value="AEB47000"/>
        <property type="gene ID" value="VAB18032_29646"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29646"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_1_11"/>
    <dbReference type="OMA" id="LVDAFWP"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="22695" checksum="28DF1FECFBF40A8C" modified="2011-06-28" version="1">MLYDCRSMADRDRGIAAAIEAVRNGELVVLPTDTVYGIGADAFTPYAVRALLDAKDAPHSPPPVLIGSRHTLDGLVFSLPTAARDLVEAFWPGALTILVQHSASLRWDLGDDSGVVAVRMPLHPVALEVLRETGPMAVASANKFGQQPALTADEARDQLGYSVRAYLEAGPAVDPVPSTIVDLTGDVPVLVREGGIGLAKLREVVPELRESQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F873</accession>
    <name>F4F873_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transporter inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10580"/>
    <dbReference type="EnsemblBacteria" id="AEB43234">
        <property type="protein sequence ID" value="AEB43234"/>
        <property type="gene ID" value="VAB18032_10580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10580"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_11"/>
    <dbReference type="OMA" id="LWIIFRE"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="289" mass="30432" checksum="911ECC4E5B56721D" modified="2011-06-28" version="1">MLTEPAPPSAPTASKRSSLLGYLRQPTVALSVLVLLVMVLMAVFAPLIADEPSGAGPDVLQSPSGAHWFGTDDLGQDVFAQVVWGTRTSLVIGLAASLIAIVLGTTIGLAAAYFRPIDAVATVITDVMLALPTLPLMIMLAAVVSPSVVTLTLIIGFFAWPEVARLIRSQGLVISAMPYIDGARVLGATGWRIVTREILPAVVSLMIVSVLLTASRAVISEAGLSFLGLGDPDAWSWGRILLNAQRSGTIAIAWWQTLFPSLAILLLVLAATLAGMRFNDSRDPRRNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8E6</accession>
    <name>F4F8E6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733146.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16935"/>
    <dbReference type="EnsemblBacteria" id="AEB44491">
        <property type="protein sequence ID" value="AEB44491"/>
        <property type="gene ID" value="VAB18032_16935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16935"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OMA" id="EFAIAWV"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="350" mass="38410" checksum="29C739FE43B0D78D" modified="2011-06-28" version="1">MLYRTLGRTGMKVSPYALGTLMFATVIGNPDPDDSIKVIHKALDAGINVVDTADAYGDSEEIVGRALKGRRDSVILATKVGFPRLNALPRAPGAAVDPNQRGASRRWIMNAVEGSLRRLQTDYIDLYQIHRPDPDTDIEETLSALSDLIRSGKVRAIGSSTMPASDIIEAQWVAERRGLERFHTEQPPYSILNRSMESEVLPAAQRYGMGTLVWGPLGQGMLTGRVRRGEQNDLRRARLSTHLTDERRIDVVEQLIPLADDAGMPLTYLAMAFAIAHPGVTSAILGPRTIEHLDNLLAGVDVTLTDEILDRIDEIVTPGTDVTRLDQAYLPPALLNPNLRRRPVSERGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8N0</accession>
    <name>F4F8N0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23375"/>
    <dbReference type="EnsemblBacteria" id="AEB45773">
        <property type="protein sequence ID" value="AEB45773"/>
        <property type="gene ID" value="VAB18032_23375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23375"/>
    <dbReference type="eggNOG" id="ENOG503176Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3141986_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="49" mass="5286" checksum="569A9468131C4FE0" modified="2011-06-28" version="1">MNHLAYLDAGSGSLIVQAVVGGVAGVAVAAKLYWRRLVSRFRRQPTDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Q7</accession>
    <name>F4F8Q7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23510"/>
    <dbReference type="EnsemblBacteria" id="AEB45800">
        <property type="protein sequence ID" value="AEB45800"/>
        <property type="gene ID" value="VAB18032_23510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23510"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004061_0_0_11"/>
    <dbReference type="OMA" id="QELYRIT"/>
    <dbReference type="OrthoDB" id="1619635at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="31791" checksum="2D3ACB220C087492" modified="2011-06-28" version="1">MGEQPQGADCPTTPQPAPVAGRPADPAVSDAESGDAGRTFSAGARLLAAAAVLVLGLGASAVVVILSDPHRLGRVFTGEGPQPQVTAESSGGLGGAARAAAQTSEEVRTAPLAGRERATFELVDGVTRFELRMADLGQELYRITSPAESDARPRPELTADRLRLRLQQLADGPGEVKVLLNARVTWQVRITGGTTERRLDLTGGRLSGVEFAGGATRTELRLPRTRGTAVVRVTGGVNVFDVTVVGGAPVRVRANAGAGDVQVYDERRDGVPAGTVLGSPEWDRSVDRVFLDLVAGAHLVTVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8W1</accession>
    <name>F4F8W1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735689.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29851"/>
    <dbReference type="EnsemblBacteria" id="AEB47041">
        <property type="protein sequence ID" value="AEB47041"/>
        <property type="gene ID" value="VAB18032_29851"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29851"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_11"/>
    <dbReference type="OMA" id="FNIRAYT"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="230" mass="24442" checksum="BA8F2A9A249F451A" modified="2011-06-28" version="1">MTDRVRRAVVVGNSDGIGLAFTRRLLADGWRVAGLSRRDNPIAVPTYTHHTVDVTAPDYPGVLGKAIDELGGVDLCVYAAGIGEPVDLADLDAQTRTFEVNLMGAVRTASTVVPRMAAAGDGHLIGLSSLADRLVSRDAPGYAGSKAGLSSYLMGLSAALRGQGVSVTTVRFGFVDTKMAKGPVRPMMISVDQAVEVLVRCVRDRPVLVSRPRRMALLTSALSPFTRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F904</accession>
    <name>F4F904_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine--fructose-6-phosphate transaminase (Isomerizing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_30066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735731.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30066"/>
    <dbReference type="EnsemblBacteria" id="AEB47084">
        <property type="protein sequence ID" value="AEB47084"/>
        <property type="gene ID" value="VAB18032_30066"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30066"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_2_1_11"/>
    <dbReference type="OMA" id="QSFYVMA"/>
    <dbReference type="OrthoDB" id="1046291at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="197"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="35513" checksum="71BCEBB339C271C9" modified="2011-06-28" version="1">MAADIDEQPAGYERLLSAEYAAPIARVAAAIAERRPRHVVFTARGTSDHAALYGAYLAEIRLGLPAGLASPSAITLFGARPDLSDALVVGVSQSGGSPDLTEVLRVAREAGALTLAVTNAPDSPLAATAELGVDIAAGHERAVAATKTYTAELLALLLLVEGIRAGDGVLPEEERRAVAELPELAARTLADPTASELAPRYRFAGQLVTTGRGYAYPTAREAALKLMETSYLPALAFSGADLLHGPLAMTDPDVPVLAVVGSGPGGQSMGEVLPRLGERRADVLVVGSAEVAGATRIAVPEVDERYAPLLDILPLQRLALALALARGEDPDAPRGLKKVTATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F4F929</accession>
    <name>F4F929_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="11" type="ordered locus">VAB18032_04655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730731.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04655"/>
    <dbReference type="EnsemblBacteria" id="AEB42057">
        <property type="protein sequence ID" value="AEB42057"/>
        <property type="gene ID" value="VAB18032_04655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04655"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_11"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="35"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB42057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="583" mass="62960" checksum="0BBA2F9239382ADD" modified="2011-06-28" version="1">MLLRMSTTLLRTLRDDPADAEVPSHRLLLRAGYLRRAAPGGYTWLPLGKLVLDRVSEIVRAEMAAIGGQEVHFPALLPAEPYRTSGRWTEYGDDIFTLADRRGAEHLLAPTHEEMAALLVKELFTSYRDLPVTLFQIQTKFRDEARPRAGLLRGREFLMKDAYSFDLDDEGLRAAYGRHRAAYQKIFDRLGLDYTVVHAVSGAMGGSASEEFLATAAVGEDTYVGCTDCDHAANTEAVTTPVPPAGDPQRPPAVEVHDTPETPTIASLVALANERALGGRTDWTAADTLKNVVLTVRRPGVEETELLVVGVPGDREVDLKRLAAALSPATVDIFDGWDAHPELVRGYIGPQVLDKLGLRYLVDPRVVTGTAWLTGANEPGRHATNVVCGRDFTPDGTVEAAEVRPGDPCPACAQGRLTMRRGIEIGHIFQLGRRYTDAFAVDVLGPQGKPVRLTMGCYGIGVSRAVAAIAEQHHDERGLVWPTSVAPCDVHLVAAGKGPQLDAAVDLGAQLAAAGLRVLVDDRVGVSAGVKFTDAELIGIPRTVVVGRRLADGYVELRDRATGERVELSLPDLLAQLAPATQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F938</accession>
    <name>F4F938_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_04700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730740.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04700"/>
    <dbReference type="EnsemblBacteria" id="AEB42066">
        <property type="protein sequence ID" value="AEB42066"/>
        <property type="gene ID" value="VAB18032_04700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04700"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_22_0_11"/>
    <dbReference type="OMA" id="QYVELWV"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="22352" checksum="CF76054973273229" modified="2011-06-28" version="1">MTVEQRARGANSGATGTGRRRSRKDEILEIAVGLFASRGYHGVSMDDIGAAAGVTGPALYHHFAGKEAMLVAALVPVSEGLLDGGRQRAAAHPGDPRAVLESLIDFHVDFALANPAVIALHLHELDRLPEEPRRRIRRLQRLYVEEWVTVLTALHAGLPDGEARVLAHAAFGLMNSTPFLGGEVDRRRRAELLRAATLAALLAPTDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9A5</accession>
    <name>F4F9A5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10905"/>
    <dbReference type="EnsemblBacteria" id="AEB43299">
        <property type="protein sequence ID" value="AEB43299"/>
        <property type="gene ID" value="VAB18032_10905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10905"/>
    <dbReference type="eggNOG" id="ENOG5031VEY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2683771_0_0_11"/>
    <dbReference type="OMA" id="DLTRIWP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="70" mass="8217" checksum="10F8E231C891FF87" modified="2011-06-28" version="1">MYNFLWNGGLMPMQPHDRHQQDLTRIWPDGHAARRFPDQPPHRSRRTGPLSWEALNRLPVGSSARHLNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9B6</accession>
    <name>F4F9B6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thij/pfpi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731981.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10960"/>
    <dbReference type="EnsemblBacteria" id="AEB43310">
        <property type="protein sequence ID" value="AEB43310"/>
        <property type="gene ID" value="VAB18032_10960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10960"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="OMA" id="GTTPIRW"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="218"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="34998" checksum="3503006DC71C442A" modified="2011-06-28" version="1">MAPVARTVAVLAYPGMSVFETGIVTEVFGLPRPELGVPWYDLRLCAERPGPVPVIGGATLHSPYGLDVLAEAATVIVPGVCDVHATPSAQLVAALRHAHRAGARLMSICSGAFALAAAGLLDGRRATTHWRYADLLARRYPAVTVDPDVLYVDDGDVLTSAGSAAGLDLCVHVVRRDHGAAVANAVARRLVTAPHRDGGQAQFIEAPVPAGADDDRVAGSIAWALAHLAEPVTVARLARQAHMSPRTYLRHFARATGTSPIRWLVDQRIRASLALLETTDAPVAQIAAAVGFETAVTYRHHFTRAMRTSPSAYRRAFRAHDGAATASVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9I1</accession>
    <name>F4F9I1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17285"/>
    <dbReference type="EnsemblBacteria" id="AEB44559">
        <property type="protein sequence ID" value="AEB44559"/>
        <property type="gene ID" value="VAB18032_17285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17285"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_5_1_11"/>
    <dbReference type="OMA" id="PVRHIIH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="162" mass="16545" checksum="D4F5CE26FB9B929A" modified="2011-06-28" version="1">MGDITREDVDAIVTAANESLLGGGGVDGAIHQAAGPRLARAGGAIGPCEPGNAMATPAFDLNPPVRHIIHAVGPIWEGGGHGEADVLASCYRRSLQVADELGARSIAFPAIATGVYGFPADQAARIAVATVRSTATNVQRVRLVAFDEDAREHLQAALTATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAC5</accession>
    <name>F4FAC5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nudix hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05300"/>
    <dbReference type="EnsemblBacteria" id="AEB42186">
        <property type="protein sequence ID" value="AEB42186"/>
        <property type="gene ID" value="VAB18032_05300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05300"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_3_3_11"/>
    <dbReference type="OMA" id="VWGEELH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="27411" checksum="1EE57851B2492284" modified="2011-06-28" version="1">MVNEQDFLAAYDPRDYPAIAVTVDVVALTIRDGALHLLLIRRGEQPYAGHWALPGGFVRPDEDLAGAARRELAEETGLGDDRLGRVHLEQLASYGAPERDPRMRIVSVAHLAFAPDLPDAAAGTDADEAVWLPVSGLANRELAFDHRQIVADGLERARSKLEYTPLATRFLGPEFTIGELRSVYETVWGQPLHAGNFHRKVLSVPGFVESTGASTERGGSRGGPRARLYRAGDAQLLHPALLRPAREEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAD4</accession>
    <name>F4FAD4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43361">
        <property type="protein sequence ID" value="AEB43361"/>
        <property type="gene ID" value="VAB18032_11215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11215"/>
    <dbReference type="eggNOG" id="ENOG5031SPV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142680_0_0_11"/>
    <dbReference type="OMA" id="DHIQMRL"/>
    <dbReference type="OrthoDB" id="1735373at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="119" mass="12878" checksum="9ED61A1C42CB0129" modified="2011-06-28" version="1">MSFDLSVWALADGATPEDVRAAVQRCREGQHGQRQPDPRVVAFYRAITASYPDRPAVPGSPWAVAPLHAAADHVELNLDPACADQVLLDIERLAGEHRLMLFDAQDGSVYPPPAARLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAE4</accession>
    <name>F4FAE4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11265"/>
    <dbReference type="EnsemblBacteria" id="AEB43371">
        <property type="protein sequence ID" value="AEB43371"/>
        <property type="gene ID" value="VAB18032_11265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11265"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054927_2_1_11"/>
    <dbReference type="OMA" id="YCDYARL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="45"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="36100" checksum="215B77CAA1F078B3" modified="2011-06-28" version="1">MPVAADPTLTDLTPNQRLRRLELTVTRRLDGLLHGERRGLLPGPGSEPAGSREYRPGEDEVRRMDWSVTARTTVPHVREVDADRELTTWLLVDASPSMEYGTAELDKRELAVAAVAAIGFLTAGAGNRLGAQVLTPYGLHRVPARGGRSHLIGLLRGLLAAPRQTGEPDGHRTADEIDLSAALAAVHRTAHRRGLVVVISDFLDGLPDDPRSPASWERPLRRLSVRHQVLAVEVVDPRELELPDVGLITLADPETGRRREVWTGDPGLRERYAAAAAAQRDQLRQALRRAGATHLALRTDRDWAADIVRHVHTQRRLALAPAAPRRGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAH5</accession>
    <name>F4FAH5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732072.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AEB43402"/>
        <property type="gene ID" value="VAB18032_11440"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG5030HZC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514500_0_0_11"/>
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    <dbReference type="OrthoDB" id="1479186at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313721" evidence="3">
        <location>
            <begin position="36"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="510" mass="53168" checksum="F3ABA1A6E13E5349" modified="2011-06-28" version="1">MFRPKLSLRRPLAVLAAAVIGSTGAAVVAATPASAHHTTITGTVDCDRLTGERVITWTVVNSERGKTATITGVTADPATPVLLVAEGTDATAELKGTPIPKAGQVQGVQRVPGDTQRATLTVEAAWFQKGDSQRKKPPTSKDHKTIELGADGTCAPAPKCVDASDAKYSHTFDGPKGTATVKLAGDLPLCGEEKQYFTLVSYFAPRPQFATPQYVYGTPDSDFLGGTQTEIELKVDVPDCHTQVDLIWGGVDEVIDPLVENGPRYGSKKLGDRGAPGNRSTGPQGWYNGGKKNCTTPAATFASACDGTVTVSLSNDGSISKYPVEFEVRGENGFSEKVTVEPGKANNETVVPAEHAGAIEVLVDGEVIDNGSYEWERPEDCPLPTITADATCETFALTASNPEGAQPVKVDFTYGDKTESRTVKPGSSESVTFPAGDDEAALVALPELDLELEVVYAPEGCGGGGGGEEPPGLPVTGVAAGGIAAGAIVLLAVGAVLFVMARRRRIHFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB00</accession>
    <name>F4FB00_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734615.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24325"/>
    <dbReference type="EnsemblBacteria" id="AEB45963">
        <property type="protein sequence ID" value="AEB45963"/>
        <property type="gene ID" value="VAB18032_24325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24325"/>
    <dbReference type="eggNOG" id="COG1785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352234_0_0_11"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307582" evidence="1">
        <location>
            <begin position="32"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="210" mass="21374" checksum="1A6885DF6A934027" modified="2011-06-28" version="1">MDTGKRKRLLAAGAAVGLLAGAVAVGSPAFAEPGDEAGVEVTVEIEEIREPGVLAMTVAADSVLLSEDGSTLLVRQFTGTLPTVTVTDTRTADEVPAGAAWAVLGSATDFVGDADQASIGAGHLGWKPKLIDGGDTGLVSEGEEVVTVLDEPTQPGNNVGLVDQELLVSTFDSGAVTPGEYTVDADLFLRTPADVEAGAYTSTLTLSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB19</accession>
    <name>F4FB19_MICM1</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45982">
        <property type="protein sequence ID" value="AEB45982"/>
        <property type="gene ID" value="VAB18032_24420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24420"/>
    <dbReference type="eggNOG" id="ENOG5032H0K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_571008_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313742" evidence="2">
        <location>
            <begin position="24"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="478" mass="51525" checksum="A95AD10D6484B09A" modified="2011-06-28" version="1">MAMIVTPLFAMSMALVAISTPAAADKPSERPRLSYARLCDPTGCYLSWRVVDSDADGVSDADEVAAGTDPHDPHSTPSLQVVVEVASVNKLPSFSYGRGSFIAFPEEILKLRETTTNLPTLGVFALPVRKDAYTRLGIDLKRFDELKLSVQRDGVAIGRGRISQSVGDPLRGSLLTPFDSHFVEYQPGVTGQSPVAHGGIVKTEKGGWFDDFDYQLHYADGSRSVVDLVPGGSVQEYFNADGSRGDTVLHQYEERGEDGGVYIEEHTWVWDVHGRLVSETTSKSHSKDGKLDSWLETIYHVYDEDGKELGTIHMESVIFTDSTHSTGSQTITTCDASGSCDDGINMYYDSDDNDSGGGHDDGGDHGDDGGDGTENDHGYVNPDYTSDVVSILTGSDGFTRIVGTNITPVRNWTPTYADGTIPENKLTGIIYVDDTANAYNSVFSEPRITGAQPEHVPGLPQPWLDGPPPNGGGCNGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB26</accession>
    <name>F4FB26_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_00435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735816.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00435"/>
    <dbReference type="EnsemblBacteria" id="AEB47171">
        <property type="protein sequence ID" value="AEB47171"/>
        <property type="gene ID" value="VAB18032_00435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00435"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="RWFGNVV"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="34069" checksum="DF9A37499E8C0689" modified="2011-06-28" version="1">MTTTSSPAPTTTSTLDLAGVSRWYGNVVAVNDVSMSLGPGVTGLLGPNGAGKTTLLHMMAGFLAPSRGQVTLDGQPTWRNPEVYRRLGLVSEREAVHSFLTAYEFVLATAKLHKLPDPQAAARRAIAMVELEGAQDRRIGTYSKGMRQRARVAASLVHDPQVLLLDEPFNGMDPRQRLHMMELLHSLGDAGRTILFSSHILEEVEQVSGTVQVMVAGRLAASGDFRTIRRLMTNRPHVFAIRSTDDRALAVALMAEPSVTGVELGRDGLTVRAGDYGAFTRVLPKVALARGVRVRQLLPEDESLESVFSYLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB63</accession>
    <name>F4FB63_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735853.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00620"/>
    <dbReference type="EnsemblBacteria" id="AEB47208">
        <property type="protein sequence ID" value="AEB47208"/>
        <property type="gene ID" value="VAB18032_00620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00620"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_11"/>
    <dbReference type="OMA" id="KESGDYM"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307772" evidence="2">
        <location>
            <begin position="34"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="81"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="543" mass="59254" checksum="9AC7DDA20D2CC168" modified="2011-06-28" version="1">MRGKFLKVAVAATATAMLATACGGGSDNDNDDAASTGGTLRVYNAEPAFLTPSGGDDEPSLYVIRSLFRGLVKYNAQTSAVEMDLAESVESDDQKLWTIKIKSGYTFDNGEAVNADAFIRSWNFAAYSPNAQNNGYFMKRIAGIKDVQSTDPDGDGPQKAPEPKAKELSGLKKVDDLTFTVELEAPFSGFPTTIGYPGFFPMAEACVADIAACNEKPIGNGPYKIDGSWQHNVAINVVRSDTWKGEPGKPDRIEYRIFADVDAGYAAFQAGELDVMYTVPPARYKEAKATYGDRMYEQPGDSFTYVGMPLYQDNFKDKRIRQALSLSIDRQSIIDAVFDGRFTPATGFVAPTFEGARADVCKYCKKDVEKAKQLLAEAGGWPAGEKLILWANAGAGHDQWLQAVGDQIKEALGIDYELKVNLQFAEYLETADQKKFTGGFRLGWGPDYPFMETFLYPLYGTGSGSNNSTYSNPEFDAAMKEGDSADSIQAAIPSYQKAEDLVGEDLPVIPMWFNKVGALYSENVDQFVWNAVSDADYAATSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBG7</accession>
    <name>F4FBG7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730936.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05685"/>
    <dbReference type="EnsemblBacteria" id="AEB42263">
        <property type="protein sequence ID" value="AEB42263"/>
        <property type="gene ID" value="VAB18032_05685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05685"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_3_11"/>
    <dbReference type="OMA" id="PRTYPAD"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="133" mass="14511" checksum="4FF0996F5CF1EDF6" modified="2011-06-28" version="1">MIDPSADRAVFRQLADLLRDRITSGDIAPGASLPSELRLAQEHGLSRTSVRQAIAILRSEGLVIVEPPRGTFVRAIEPTETVKLLKGDTASARMPTPAERRELEIGEGVPVLVIFRADGSRELYAADRVRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBN5</accession>
    <name>F4FBN5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11915"/>
    <dbReference type="EnsemblBacteria" id="AEB43497">
        <property type="protein sequence ID" value="AEB43497"/>
        <property type="gene ID" value="VAB18032_11915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11915"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013247_0_0_11"/>
    <dbReference type="OMA" id="SGFQCGV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="881"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="916" mass="96370" checksum="ED6C2D0BB0C1D385" modified="2011-06-28" version="1">MSEQGRPRFGKARTAEFVGSWRAALRIARREARRARGRTALVLSMIILPVLALTFVAVSVDMSRLTADERLDRQLAAADAELRLVSRAGPITQSGNGDHWNVAVENDDETTEVPRPPSTQEIAALLPEGSHVLPVVRWLPITTWDDDQDHMHELTASVVDLTDPLGRGLAHIHAGRAPVGADEIAVNPAARRKLGVALGDQVNASNGRQSWTVVGVIEAPDQLSPAAILHPAGVPPGAVEIDPVFLVDLPGPITTDLFRHLNDHGVVVTTRTPAPPTEYDAAWRGGIGAREELSLGVLIGGLGLLEVVLLVGPAFAVGVRRRRRELALVAVAGGDAAQLRRVVLADGVVLGAVGALLGIALGIGLAVAGRPLMEEFVFQHRFGGYRFWPAALVVIGLVAVLAGVLAALTPAWMAARQDVVAGLANRRTPPVHSRRWLIVGLLLAAGGAAVAALGAVVSSDSVTLAGLLVGELGLVFATPTLVGLVARVGRFLPLVPRMALRDASRNRSSAAPAISAVMAAVAGSVALGLLLVSEQARDEERFRPSLPDRSVLVSVDGAPGDHSPPTLAEITEPAREHLHARAIAPLMSAGCVRLPDNCLITATLPPERACPWRSDRTLSEAEQLQARADPRCQGRPDDYFGLTFRVAVDDGSALPILTGAGPDQVAAATAVLRAGGAVLTDPRYVVDGRVELQVLRHLDEERQEQVRTLEVSGHALHHDLDMKWLLLSPAAADRLGLVTRHTGWAIGSDSVPEQEQQIRFNTAIRAIGPLGVEISDAHYRSGTLGGLLLLAGVSAVVTVGATASATGLAAAEGRADLSTLAAVGASPRVRRLLSLCQAGVIAVLGSALGIVAGLGAAMIILLSTNQRYVDTWPIEPPYPVIVPWITLGVLVAVPLVAMVGAALFTRSRLPVERRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBY0</accession>
    <name>F4FBY0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, hxlr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18390"/>
    <dbReference type="EnsemblBacteria" id="AEB44780">
        <property type="protein sequence ID" value="AEB44780"/>
        <property type="gene ID" value="VAB18032_18390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18390"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_0_0_11"/>
    <dbReference type="OMA" id="TIFIHEC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="19562" checksum="49F0AE35B9BFC03A" modified="2011-06-28" version="1">MALRRYGQDCSIARALEVVGERWTLLIVRNAMVGDCRFESLLDSLGIARNVLAQRLTTLVEAGVLERVPYRERPVRHEYRLTERGRELAPVLAALMRWGEKNCPTDQPPPNRALVHARCEHPVELVVHCPSCDESIPTSEMVSRPVVRSAVETHDPQPSADGRPSAVLAATVPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCA0</accession>
    <name>F4FCA0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PKD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00975"/>
    <dbReference type="EnsemblBacteria" id="AEB47279">
        <property type="protein sequence ID" value="AEB47279"/>
        <property type="gene ID" value="VAB18032_00975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00975"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002470_2_0_11"/>
    <dbReference type="OMA" id="QAGLIVY"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307787" evidence="3">
        <location>
            <begin position="34"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="4">
        <location>
            <begin position="723"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="917"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="927"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1919"/>
            <end position="1946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1946" mass="207335" checksum="132FB5438545636D" modified="2011-06-28" version="1">MSRPPRARVPITATLLTLGLAATGLVGVPAAQAAPSTKAVAQSTPVNQAAPAANAAAEDFSVLVFSKTAGFRHDSIPTGIAAIQQLGATNGFTVDTTEDGAAFTDENLARYEAVIWLSTTGDVLNAEQQEAFERYIQAGGGYAGIHAASDTEYNWPWYGELVGAYFANHPANQTATVKVEDPAHESTAHLPERWSRYDEWYNFRTNPRGKVHVLATLDERSYSPGAGAMGHDHPIAWCRDYDGGRTWYTGGGHTRESYAEPEFLQHLLGGIRTAAGVSNADCRASLTSSFEKVTLDSNTSNPMELDIAPDGRVFYIERDGRVQIIKPDTGNTVTAIDLDVFTGNEDGLIGIRLDPNFATNNWVYLYYAPNDGIARNLLSRFTVTGDSIDPASEKQVLRVDTQRNTCCHAGGTMVFDSDGNLYLATGDNTNPFSSDAYTPIDERPGRADYDAQRSSGNTNDLRGKVIRIHPEDDGTYTIPEGNLFPPGTEKTRPEIYAMGFRNPFRIGIDLATNVLYVADYGPDANSANPNRGPEGLVEWNIIDKPGNFGWPYCHGANKAYNDYQFPSGPSGAKFDCANLVNDSPNNTGLTNLPPAVSATVDYGYAPNPLFPEIGGGGAPMGGPVYRYDADLNSDRKWPAYFDGKAMFGEWNQSRMYTMQVTADGKSLVDINRLLDGMSFIRPMDFEFGPDGALYMIEWGSGFGGNNDNSGVYRIDYIAGDRAPVAVANADPTSGPAPLTVTFSSAGSRDPDGGALTYAWTFGDGNSSDEANPTHTYASAGNYNAQLTVTNPKGRTAVANVPVTVGNTVPTVTIEFPPDGGFFDWGDQVKYTIKVTDPEDGEIDCADVELQVLLGHDEHAHPLEQHTGCEGVVQTQLAAGHGAEANVFTVLEATYTDKGGAGGASPLTGRALEILQPKRKQAEYYSNTGRLAGSTGGGDPGVGKEATGDTAGGGDNIGFIEDGDWWSVEPASLTGIESIRFRVASATTGGRLEVRAGAADGPLVTSVVVPGTGDWQSYTDVTAEVPADADSNGKLFFVARDPAGGSASLFNVNWIDFLGKGVTDNAPPVVTANATPTSGTAPLTVAFSGTATDPEGDTPLTYEWDFGDGGTADTLNAEHTYAAPGNFTATLTVTDSRGARSYATVPVRIESPNTSCLGARSDDFTGDTLNRDRWTSVVRENQLLSVSDGALRLPTGVGDLYGDRNDATNLVLQPAPSGAWQATTKVTVPVTATYQQAGLIVYGDDDNYAKVDLLYNGSRRVEFLRETAGTPRNDSADNVAAPDGDTVYLRISSDGTNLTAEMSADGQTFSPVGRSAALAGIENPRIGLFALNGGTDAPVVEAVFDWFQVTPDSPAGPVDPSDEFDGISLDKCRWNAILREDPSAYRVSGGKLYVDVPNGDIYGTNNTDPTNFIMQNAPTGDWTMETRIDGSLLDEQYQQAGLIVYGDDDNYLKFDFVVDNQAGQPVTRRIEFRSEIDGVIQNPQPGAENLTSSEWYLRVSRAGDTFTASYSADGTTWTALTELVNAAVGATPKVGVFTLSGNQTASKVASFDYFRFSADEVPSDTVAPVTTAEVSGTPVEGWHTGPVTVTLSATDSEGGSGVARTEYQLGEATEWTAYTDPVQVTGDGEHELRFRSVDEAGNVEETKTVTVRIDTTAPVSTASFAPANDEGWHNGTIPVVLTSTDAGSGVQLLEWSLDGGAWTPYTEPVEISGDGTHELLYRATDKVGNAETLKSAVVRIDGTKPTLLVSGIADGQLYGDSQDVRVSWQAVDPTSGIATVVGTLNGRPYASGTLQAMYELPLGLHELTVTATDKAGNATTASVRFFVTTSFRDMQNLLDRFKATGRLSNKAYDQLSKQLEKVRKEEAKGKDDKAIKELIKFRDLAADAKLVAEAEIREVLIRDADAMIVRLGGTASTAGVKANDGKSVKGAGRLGGDPTRLAPGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCB6</accession>
    <name>F4FCB6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">adk</name>
        <name evidence="10" type="ordered locus">VAB18032_01055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735936.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01055"/>
    <dbReference type="EnsemblBacteria" id="AEB47295">
        <property type="protein sequence ID" value="AEB47295"/>
        <property type="gene ID" value="VAB18032_01055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01055"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_11"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="23431" checksum="654366F5C6C2A4B1" modified="2011-06-28" version="1">MRLVLVGPPGAGKGTQAEFIAAHLSVPKISTGDIFRANVSQGTPLGVEAKRYMDAGKLVPDEVTINMVRDRLAEPDTAEGFLLDGFPRTTPQAAALDKLLADLGTALDIVLELVVDDDEVIRRLSGRRTCRGCGKIWHVEFDATSREGICDRCGAELFQRDDDKPETIAARLREYADKTAPLVDYYGAQGKLVGIDATGPVEDVTVRAIDALRSYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCD0</accession>
    <name>F4FCD0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rplP</name>
        <name evidence="10" type="ordered locus">VAB18032_01125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735947.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01125"/>
    <dbReference type="EnsemblBacteria" id="AEB47309">
        <property type="protein sequence ID" value="AEB47309"/>
        <property type="gene ID" value="VAB18032_01125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01125"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_11"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="15962" checksum="3D7C64599CADFE3F" modified="2011-06-28" version="1">MLMPRKPPKGFRKPHHPDRSGASKGGNRVVFGEFGIQALEPAYVTNRQIESARIAMTRHIKRGGKVWITIFPDQSLTKKPAETRMGSGKGSPEWWVANVKPGRVLFEMSFPNEQIAREAMRRAIHKLPMKCRIVTREVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCG0</accession>
    <name>F4FCG0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730960.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05805"/>
    <dbReference type="EnsemblBacteria" id="AEB42287">
        <property type="protein sequence ID" value="AEB42287"/>
        <property type="gene ID" value="VAB18032_05805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05805"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129722_1_0_11"/>
    <dbReference type="OMA" id="NIYKYAT"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="40"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="14412" checksum="AB120608E594F59B" modified="2011-06-28" version="1">MTSGVDLSRPQAQTVGSDEDVVRVRQLVRTVAVAVKLSLVDQTKVVTAASELARNTLVYGGGGTVEVTAVDNGRRPGITIVFADSGPGIGDLELALTDGYTTGGGLGLGLSGARRLVDEFDIQTAPGQGTRITITKWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCP7</accession>
    <name>F4FCP7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">VAB18032_12135</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732210.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12135"/>
    <dbReference type="EnsemblBacteria" id="AEB43541">
        <property type="protein sequence ID" value="AEB43541"/>
        <property type="gene ID" value="VAB18032_12135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12135"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_2_0_11"/>
    <dbReference type="OMA" id="TYWCPRC"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08971">
        <property type="entry name" value="AcNei2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044090">
        <property type="entry name" value="Nei2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="17">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="16">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AEB43541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="29287" checksum="C709D41A492A8F7D" modified="2011-06-28" version="1">MPEGDTVWNTARVLARALTGARLTGSDFRVPQLATTDLTGWRVTDCASRGKHLLIRLDEPTGAAHWTLHSHLRMDGTWRVYAPGERWSARPAHLIRVVLSTATSTAVGYHLHEVALVPTAEEHRLVGHLGPDLLGTDWDPQEAVRRLADRPAESIAEALLDQRNLAGVGNLYKCELLFLRGINPRTRVADVPDLAGLITLAHDLLAANRGRWTQSTTGSLRRGQTSYVYGRRAQPCRRCGTAIRKEELGERVTYWCPRCQPAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCW5</accession>
    <name>F4FCW5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733452.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18475"/>
    <dbReference type="EnsemblBacteria" id="AEB44797">
        <property type="protein sequence ID" value="AEB44797"/>
        <property type="gene ID" value="VAB18032_18475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18475"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_11"/>
    <dbReference type="OMA" id="YTQMPAS"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="35465" checksum="BBA6AD3B91D70D73" modified="2011-06-28" version="1">MRVLVTGGTGFIGSHTAAALLRAGHEVRLLVRDPDTVGPALEPLGASTADVATVTGDVTDARSVGRAMDGCAAVLHAAGVYSFDTRRHAQMWQVNVGGTEVVLDAARAADVETIVHVSSVVALAPTGGAPLATDLPVGRPRERYMATKAAAEEIARRHQAAGSPVIITYPMATLGPHDPYVGDQAARLRALLRGQLPIWPGGGFPVGDVREVADLHVAALRPGPGPRRLLAPGRTLSTREFVAAVREVTGRRLPVAYLPSAAVLPVGAAASAFQRIWPWHVPVEYGAVYTCHCDLRTGPQVPAPTRPVTETIRDTVAWLYRTGRISRRQAGLAADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD19</accession>
    <name>F4FD19_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733506.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18745"/>
    <dbReference type="EnsemblBacteria" id="AEB44851">
        <property type="protein sequence ID" value="AEB44851"/>
        <property type="gene ID" value="VAB18032_18745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18745"/>
    <dbReference type="eggNOG" id="COG1971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459130_0_0_11"/>
    <dbReference type="OMA" id="MLWSTDG"/>
    <dbReference type="OrthoDB" id="410703at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="604" mass="65325" checksum="BD21A7960146F21E" modified="2011-06-28" version="1">METTRRKSLGTSPTDDQQPGPEQEESTPDPGAGEAGPTGALATASRLLRHEWTLASLAGLLLAVVLTWPTLKHPWTTIPGDIGDPTLQAWQVAWAGHALITDPLALWHSNALFPEAYTYAYTDTLLGYAPVGMLGGSMEAAVFRYNLLYVFAHALAFVGAYALVRQLGGIRTAAAVAGIAWAFAPWRLAHSGHLNILSTGGIALCLAMLARGHGWSLREGHRPALHRPGWIVAGWLVATWQVLLGLAIGLPLIYILAGAGLVVVAAIGWRRWRSGRWILGRRVVLANLFGGVVFGAVCIWLGTTFLRVVELYPQARRDLSWTEMFSPPLGGYFIAPADSWLWGDYFEPARAQLTWPPEMALLPGVTLIMLGVAGLSYSVFRLRHRLLLGLGVLVSGALGLGSNLLGDGDPGYMTLSRLLPGWDALRTPGRLMVWTSLLLAILAAGAITEFGRQLPTMRWPRVVGRIVLVLPLLLVLVEGVNRTPHPVAPPAPTAIRSAPEPLLVLPAEGISEFHVMLWSTDGFPRVANGFANFVPPHQQQIRSVSMTFPDANSIAYLRQVGIRSVVVLPDQLFGTPWDGVTTRPLDGLGITREEVDGAFVYHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDA6</accession>
    <name>F4FDA6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734788.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25190"/>
    <dbReference type="EnsemblBacteria" id="AEB46136">
        <property type="protein sequence ID" value="AEB46136"/>
        <property type="gene ID" value="VAB18032_25190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25190"/>
    <dbReference type="eggNOG" id="COG3917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087602_1_0_11"/>
    <dbReference type="OMA" id="DPMCPFA"/>
    <dbReference type="OrthoDB" id="996965at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="20735" checksum="A528C74F4EAE69B6" modified="2011-06-28" version="1">MDATFFFDPACPWTWRTSRWLVAVAEARGLSIEWRAFSLSILNGGNIPPEYADAVAASTRALRLVEALRAEGRHADAGRFYAELGARTHDAGNPPSGKIVDAAVEAAGLDDMAAALDDERWDEAVHASHALAYGSAGPDIGSPVLMVPDADRGIHGPILTEVPATDDALTLWDNLLPLLRMPAFHEIKRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDE7</accession>
    <name>F4FDE7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735994.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01370"/>
    <dbReference type="EnsemblBacteria" id="AEB47358">
        <property type="protein sequence ID" value="AEB47358"/>
        <property type="gene ID" value="VAB18032_01370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01370"/>
    <dbReference type="eggNOG" id="COG4320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032121_1_0_11"/>
    <dbReference type="OMA" id="HADPWLG"/>
    <dbReference type="OrthoDB" id="571864at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="438" mass="48191" checksum="58C79F0B71E381AB" modified="2011-06-28" version="1">MTDLAEKRSAFIVEVLAQEFGALMALDPAAFRRKFRKMAASPFAFYRGSASLFYADQRGDFADDRFLDDQTSRVWIHGDLHAENFGTYMNGSGQLVFNVNDFDEAYVGPFTWDLRRFVASVALIGYTKALSDRVISELVAGFAESYLTELRAIAEGGDDAIGSITLDNADGVLRRVLQQARLNTRVDLLREQTTIDAYERRFSLRDGVYEVDGDVRAKVCAAFEAYLDTLPAATAQNRPLAAQIKDVVLRKGVGIGSAGLPSYNLLLEGHTQALENDVIIYMKQAQVPAVARHVDDEGVRGYFRHQGHRTAESQRALQAHADPWVGFTELDGVGQLVAEVSPYAADLDWADVNEPEELAGVLADLGRAVARMHSVADDESSHDLVDYSTEEAIVAVVAADPAGFVAHLVDFAHAYGVRARQDHQLFVDLFRNGRLPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDN6</accession>
    <name>F4FDN6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fad-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731072.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06375"/>
    <dbReference type="EnsemblBacteria" id="AEB42399">
        <property type="protein sequence ID" value="AEB42399"/>
        <property type="gene ID" value="VAB18032_06375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06375"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003896_4_3_11"/>
    <dbReference type="OMA" id="YPRFGEF"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="437" mass="47720" checksum="FB75EA6035FB5C53" modified="2011-06-28" version="1">MPGSSASDATAWSNWAGNQHSTATVLRPTSVTEVVEQVRSAAETGARIRPVGSGHSFTPVAVGDGSRMDLAGLAIDVQVDVDRRLVTVPAGMTLRQLNALLASHGLALPNLGDIDAQTVAGAISTGTHGTGAAYGGLATFVAALTLVTGTGEVLHCSADEHPDVFDAARISLGALGVLVEVTLRCVDAFVLRAHERPAALDAVLADLPDLIGTHDHVEFFWFPYSSQAQLKVNDRVPDDDRPLPRWRGWLDDDFLANTVFAGACRLGRAMPALVPTISAVSARALSERVYTGRSDTVFCTPRRVRFVEMEYALPRDALPEALDALRRIIDRLPFRVLFPVEVRFTAADQIWLSHSYGRESAYVALHQYVGMPYEPYFRAFEQVATELGGRPHWGKLHWRDAASLADAYPRWHDFHRIRTHLDPHRTFTTPHLTALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDP9</accession>
    <name>F4FDP9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_06440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731085.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06440"/>
    <dbReference type="EnsemblBacteria" id="AEB42412">
        <property type="protein sequence ID" value="AEB42412"/>
        <property type="gene ID" value="VAB18032_06440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06440"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="PYHLSYG"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="26970" checksum="34520089453A278A" modified="2011-06-28" version="1">MTLELMGVSQRYGNVVALREVSARLKPGVTGLLGPNGAGKTTLLRTMATIMPPDAGVLHINGVQVNDERSARSARRHVGYLPQSFGYDPHMRVGDFVRYAAWLRGLPAAQWDAGAKAALSAVDLLDRATIKLKKLSGGMRQRAGIAWAIVGRPAVILLDEPTAGLDPRQRLQFRKILTDLSDSVVVLSTHIISDIDSTCDRVLVISDGQIRFDGSTAELSRSGRDDLPGHTSLERAYLHLLPEQETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDT8</accession>
    <name>F4FDT8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12525"/>
    <dbReference type="EnsemblBacteria" id="AEB43619">
        <property type="protein sequence ID" value="AEB43619"/>
        <property type="gene ID" value="VAB18032_12525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12525"/>
    <dbReference type="eggNOG" id="COG4710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2260514_0_0_11"/>
    <dbReference type="OMA" id="MNRNDAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="105" mass="11390" checksum="6178D9A2C6E76573" modified="2011-06-28" version="1">MTMDRHDATKQFHSGGERLAELIDESRAVELPVPDTDTPMVSRSVRLPLETYERVRAAADARGIGVTTLMRQWIEAGLADLDDSATVSLADVRRAIASLAQPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDX3</accession>
    <name>F4FDX3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine dehydrogenase/ phenylalanine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_12700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732322.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12700"/>
    <dbReference type="EnsemblBacteria" id="AEB43654">
        <property type="protein sequence ID" value="AEB43654"/>
        <property type="gene ID" value="VAB18032_12700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12700"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_0_0_11"/>
    <dbReference type="OMA" id="AADQFCE"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="6">
        <location>
            <begin position="151"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="363" mass="37914" checksum="FB5FD128E0EF8D13" modified="2011-06-28" version="1">MSAPQPSAPVFGRFPDFPHEQVTFCQDPETGLRAIIAIHDSTLGPAVGGTRFHPYASEAEALTDVLRLSRGMTYKNAVAGLPCGGAKAVIIGDPDTIKSEALLETYGRFVQSLGGRYVTAGDVGISAADLDVIGRGTDHVLGRTTTAGGYGDSGPMTAYGAFHALRAAAAVRWGTAELAGRTVGVEGLGKVGYELVRLLVEAGATVTAADISAPARERVRRELPAVLLAERVIDAPVDIYAPCALGATLTSDSVPTIHAAVVCGAANNQLATPEVEQQLVERDILWVPDFVASAGGVTTGSAEYRRIPLEEVPAQVAKIFDTVTEVLDLARRQGILPGAAAEDLAHNRIQQARTGLKPGYLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE20</accession>
    <name>F4FE20_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transporter inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733544.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18935"/>
    <dbReference type="EnsemblBacteria" id="AEB44889">
        <property type="protein sequence ID" value="AEB44889"/>
        <property type="gene ID" value="VAB18032_18935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18935"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_3_11"/>
    <dbReference type="OMA" id="WDGAIVF"/>
    <dbReference type="OrthoDB" id="1694312at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="28788" checksum="EADD0695E1A00247" modified="2011-06-28" version="1">MTTGSRTPAHTRRPAGTTGRRVLGILGLLLAAIGYEAVTRAFFSPLHVPPLTAIVPRAAELLTEARFWTATGRTLLVSAVGLLIALVAGVVVGFAVGSVPWLLRAASSTLDFLRPVPSIVLIPVLVLVLDVGQITVLLVAVSCFWIVLFQVLYGLRDVDQVAVDTARTIRLGRLGRIIHVTWPSVLPYLGTALRLIVSVALALAITGGLVMGAAGLGELIWSSQESGEFTGMYALVLLTGGVGIALDMAARLAERRLLHWHVATRREVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE48</accession>
    <name>F4FE48_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733572.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19075"/>
    <dbReference type="EnsemblBacteria" id="AEB44917">
        <property type="protein sequence ID" value="AEB44917"/>
        <property type="gene ID" value="VAB18032_19075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19075"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_1_2_11"/>
    <dbReference type="OMA" id="YDSVVPH"/>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="178" mass="18952" checksum="92EE31475FA48051" modified="2011-06-28" version="1">MLGDRLRDLRQQHSMTLRQLATAADVSPALLSQIENGATDPSLSTLRKLAQVFDTSIAELFSEPEAPAVHLSRAGNRSRLTAPPGQITYERLTPGRGDLEVLQAHLAPGDASSAEPWAHPSTECAIVITGEVVAEIGGEKHVLAAGEAVTFDSRLAHLYRNASDEPAHLIIAVTPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FED5</accession>
    <name>F4FED5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA/rRNA methyltransferase (SpoU)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25515"/>
    <dbReference type="EnsemblBacteria" id="AEB46201">
        <property type="protein sequence ID" value="AEB46201"/>
        <property type="gene ID" value="VAB18032_25515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25515"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_3_11"/>
    <dbReference type="OMA" id="GYHVHRG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="117"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="28748" checksum="2E6AD3CA3F57FE24" modified="2011-06-28" version="1">MELITEPDDERIADYRALTDVELRTRWEPPHGLFIAEGELVLRRALRAGYPARSYLVDAKRVDQLADLDTGDAPVYAATPDVLQEATGFHVHRGVLASFRRKPLPSAAEVLATARRTVILEDVNNHTNLGAIFRAVAALGVDAVLLSPSCADPLYRRSVRVSMGEVFAVPYAKLDPWPTALAQVRDAGFTVLAMTPAPDAVPIQRLTPAQRARAALLLGAEGAGLTQAAMAASDVRVVIPMRRGVDSLNVAAATAVACWELGRDDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEK4</accession>
    <name>F4FEK4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01810"/>
    <dbReference type="EnsemblBacteria" id="AEB47446">
        <property type="protein sequence ID" value="AEB47446"/>
        <property type="gene ID" value="VAB18032_01810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01810"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_0_2_11"/>
    <dbReference type="OMA" id="MQLLGAC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="37368" checksum="8D27278181061208" modified="2011-06-28" version="1">MTGVSRYLGAHVAARLVTDPRIERVIGIDLRDPSPEVAGLLDQVERIRVDAGSVGGLLADLDVDTVVHLALASAPDQQQGGRAAMKEQNVIGTMQLLAACQRAPRLRKLVVRSSTAAYGASFRDPAVFTEETEPREVPRGGFGRDILDIEGYVRGFRRRRPDVTATVLRFAPFIGSTADTTLTRYFSLPVVPTILGRDARLQFLHFDDALEVVHRSVTEDHPGTYNVAGPGVLALSQAIRRAGRLAVPMLEPGLSGAAALARTMGLGRYGLDQVDLLVHGRVVDTTRLEREYGFTPRSTAAAFDDFIRAHHGRSVVTREQLAAAEQLVLDQIRRVRAAVQEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FER1</accession>
    <name>F4FER1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731128.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06655"/>
    <dbReference type="EnsemblBacteria" id="AEB42455">
        <property type="protein sequence ID" value="AEB42455"/>
        <property type="gene ID" value="VAB18032_06655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06655"/>
    <dbReference type="eggNOG" id="ENOG5032SQA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150044_0_0_11"/>
    <dbReference type="OMA" id="FPHAVQW"/>
    <dbReference type="OrthoDB" id="1893426at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014447">
        <property type="entry name" value="UCP006909"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006909">
        <property type="entry name" value="UCP006909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="11744" checksum="A6EB465305DF0610" modified="2011-06-28" version="1">MIFRAVRDGRPYPEHNLTLKQWAEIPPRPLRLDQLITTKRELALDKLLAEDSTFYGDLFPHVVQWNGGLYLEDGLHRALRAALQQRNQIHARVFVLAESVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEV5</accession>
    <name>F4FEV5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731172.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42499">
        <property type="protein sequence ID" value="AEB42499"/>
        <property type="gene ID" value="VAB18032_06875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06875"/>
    <dbReference type="HOGENOM" id="CLU_140176_17_1_11"/>
    <dbReference type="OMA" id="YEIRHLL"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="63" mass="6989" checksum="7E06D1A9B7B4E837" modified="2011-06-28" version="1">MDLLGLDEIRDLLGGISKQRATIIVGRKGFPDPVVTLKMGRVWDGKAVRAWIAENRPTPTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEY4</accession>
    <name>F4FEY4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12910"/>
    <dbReference type="EnsemblBacteria" id="AEB43696">
        <property type="protein sequence ID" value="AEB43696"/>
        <property type="gene ID" value="VAB18032_12910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12910"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350184_0_0_11"/>
    <dbReference type="OMA" id="RPWAGGW"/>
    <dbReference type="OrthoDB" id="1790198at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="767" mass="82692" checksum="6BD35ED2FEE473D4" modified="2011-06-28" version="1">MNRDRQLPEDGTLTHEVVELRVHGVSGTSAETLLDHPVVIRVAGDDNAGFYRPRPGFGISDRPSGLKVEAYRWGALTAGAAVRTLSLLFLLPFMLVNLAVWARPATGGAGGLIGPLCRLLAATLTAAFVLSVVGVSIDLVGWQCVGYQPCRAGRGYLAWLGSLPLGPRLAILALVPIAALRLLWWLGARSSRAFEAFPARPGQARDALGEDRIDEPGFWNDAIVVRRLLTLHVAVGLGILDTILLGAQIHLRPTPVVYVLFGTAWCLLAVAAVLLCRPARAVDEGPGRGPVDMRGVRRLRQATTVVTLLALAYTVVPLEPEPPHGQLPGYEGAVAALIAVQAGLLIALTVTTWHQRRRSRAGTPLWLGGLAGPLLATAAVAAAYGFAAALVYRVADFLDRSDIPNPARPDRPGAPPLEPPVSYRWAALAGLAAIMVVAIAALWRIVATRRRRRRMAEQIVRRDFPDPPPEALPQRAAVREVVARAAFTEQLGPIFIVFLVLSLLGVAIVALDLIGVGPSELSRYLARTDGQATTNLSLVTDVGIYVIGLVAAGIVVLGLASYRSEGTRRSVAVIWDLGTFWPRTVHPFAPPCYAERAVPELAKRVSALARKGGVILSGHSHGSVLAAATLLQLPPEVLPRVALLTHGSPLHRLYSRLCPAFLGDDVLHEIGDRIGWRWVNLWRDTDPIGGPVFSAHWPGQPPRVPPPAGTVDRRLRDPVEVTVPPDDTVPPRIDQHWPYHTDPQYEAAVRELAGRLDPDLLHLSRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF23</accession>
    <name>F4FF23_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13105"/>
    <dbReference type="EnsemblBacteria" id="AEB43735">
        <property type="protein sequence ID" value="AEB43735"/>
        <property type="gene ID" value="VAB18032_13105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13105"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051479_1_0_11"/>
    <dbReference type="OMA" id="RRFPARD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="34251" checksum="7A774709789DEF7A" modified="2011-06-28" version="1">MTTALAEAAAMAGHAPSVHNTQPWRWRVLPEALELRLVSDRQPTATDPTGQLVMLSCGAALHHARLALAAEGWTATVHRMPDPGEPELLARLTDPKASGVDPDAMRMVQCMQVRHTDRRPVSEEPVSEEHLTAIASAAAGEGAHLEILDRDQVLQLAAAASHAAEVESEDSQLRAELDYWTSRAGGSGLPPEVLLQQPAQTTVPGRDFGRPGTLPGGPGHDRAASYGVLYGDEDDPRAWLRAGEALSAAWLFATRLGVSVVPLSGVVEVGGTRQILRQVLAGFGHPYLVLRLGIADPEHAGPPHTPRLPREQVVDTTAVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF37</accession>
    <name>F4FF37_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732417.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13175"/>
    <dbReference type="EnsemblBacteria" id="AEB43749">
        <property type="protein sequence ID" value="AEB43749"/>
        <property type="gene ID" value="VAB18032_13175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13175"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_8_11"/>
    <dbReference type="OMA" id="FAIAPFE"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="55"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="30597" checksum="B7B5197AACB90A4F" modified="2011-06-28" version="1">MSTGAPGRGTASRAPLRLALAAPADAAGLTSQWRHVDGLRTHVRRSVDAPPGTPVLLVHGLAVSHRYLTPLAVALADHHPVYAPDLPGFGLSAHPAEAYDVPRHADHLAALLAAYRLPPVCVFGHSFGAEVAAALAVRHRHAVRALVLAGPTSDPRARSRTGQLRRLLLDLPREALWQAPVLVRDIADARPRRVWATLSHSVRNRIEDDLTRLTVSTLLLTGARDPIAPPAWRDRAAALVPQVRTVSVPGAAHNVASTAPRQVAEAVRALLDDRVLDRLDTLTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFF7</accession>
    <name>F4FFF7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SQHop_cyclase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25805"/>
    <dbReference type="EnsemblBacteria" id="AEB46259">
        <property type="protein sequence ID" value="AEB46259"/>
        <property type="gene ID" value="VAB18032_25805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25805"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041269_0_0_11"/>
    <dbReference type="OMA" id="RWHASPY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SQHop_cyclase_C" evidence="1">
        <location>
            <begin position="348"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="536" mass="55658" checksum="0B9F072C941071F5" modified="2011-06-28" version="1">MTAPTLTLGAVAAPGLTDAVGDLLAQLEQHPYGQVSTSVYETARLVADAPWVDGHAPRLAYLLAEQGADGSWGPAGGYALVPTASAVQALLASLVRADPPDPAGPGRSEVVAAATRGLAALVRCLGDDAAVPDTPAADLIVPALVARIEAHLTELAGAPTLTDAPGALPGVDRRRVDAVNALLTSGRPVPSKLWHAYEVLGPAAATRDDVAPVDGAVGASPAATAVWLGHRRTDDPAARRYLDAVVARQGGPVPCCTPITVFERSWTLATLARVGLPVDPGARLLAELAAALGPDGAATGPGLPADADTTSTVLYALARLGRPVDPVSLLHYDLGSHFCTWRGEDGQSVTTNAHVLEALGWHARHGADRYTARVASLAGWLRDVQGPDGLWTDRWHASPYYATCCAVSALAGHAPPEVADTAIDRAVERILADQRDDGGWGRWSSTAEETAYAVQILLGSGRPIRPAVTAAVCRAVGHLRADRSDYPPLWHDKDLYAPILIVRAAVIAARKLVLAVAPTINQALSTTTPEAGRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFN1</accession>
    <name>F4FFN1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02120"/>
    <dbReference type="EnsemblBacteria" id="AEB47508">
        <property type="protein sequence ID" value="AEB47508"/>
        <property type="gene ID" value="VAB18032_02120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02120"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711606_0_0_11"/>
    <dbReference type="OrthoDB" id="1200881at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="388" mass="43296" checksum="93164316385AE97A" modified="2011-06-28" version="1">MSSLVLLLIIGSFGYGFLRPAVGYQPRHAARPPLYGPVRADQVAILIACRNGAATIAATVRAARATGSDVYLVSDASTDETAELAAGAGAWVLPLTHNVGKPAALHTAYEAFELGRRYRAVAILDDDVVVAPDFVTAALDKMTDEVSIVVGHNATWWPPERRWNPWLAKRAYSYWMYQAVIRRIQSHFNVMNCISGSNSIYRTELLDVVLPTQPPYIVDDTYWVLETHRRNLGRVVYAPRALAHLQDPTNLRDWYRQNLRWMWGTFQGVIGHRVGRYATRFDYAYLLLILHWLLYVAGGPLTLWLIATAGPGLLPGLLFLLAGHGIWVGIAAWRLRHPQLPLFLPVIIVADLLYRVILVHALVKAIRQPTVERCVWDSPARIAVGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFY0</accession>
    <name>F4FFY0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07180"/>
    <dbReference type="EnsemblBacteria" id="AEB42560">
        <property type="protein sequence ID" value="AEB42560"/>
        <property type="gene ID" value="VAB18032_07180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07180"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078797_0_0_11"/>
    <dbReference type="OMA" id="LEDSWES"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="29533" checksum="4102266FC5BAFD5B" modified="2011-06-28" version="1">MTTPAVTTPAVRQLRPPTPGGPLVAFVHGLEDSWESWLPLCNVLPEWTPVALDLPWRPGNDYLWRRRPSPAWLADGLDLLGRRPDLVVAHSFGANALLELLCAGDRRVPETVILICPLYRPPDVAVTWRVFERARRSFEQHIHDSLRSRLGPRLRNMDAEVVERMIAKAVDRVGPSGFLAVFDQFCASASLRLDQVTARVLVLAGGSDPTLSPAAARILADGMPHAVLSVGDSYDHFCYARQPEDVASRLRAFVDVASVVSGHPEGVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFY2</accession>
    <name>F4FFY2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-hydroxychromene-2-carboxylate isomerase</fullName>
            <ecNumber evidence="1">5.99.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_07190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate</text>
            <dbReference type="Rhea" id="RHEA:27401"/>
            <dbReference type="ChEBI" id="CHEBI:59350"/>
            <dbReference type="ChEBI" id="CHEBI:59353"/>
            <dbReference type="EC" id="5.99.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. NadH family.</text>
    </comment>
    <dbReference type="EC" id="5.99.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731235.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07190"/>
    <dbReference type="EnsemblBacteria" id="AEB42562">
        <property type="protein sequence ID" value="AEB42562"/>
        <property type="gene ID" value="VAB18032_07190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07190"/>
    <dbReference type="eggNOG" id="COG3917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_1_3_11"/>
    <dbReference type="OMA" id="KFWGVDR"/>
    <dbReference type="OrthoDB" id="996965at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018845">
        <property type="term" value="F:2-hydroxychromene-2-carboxylate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="27527" checksum="EDBEEA3FA4EAA72F" modified="2011-06-28" version="1">MTRAPARPRLFFSFRSPYSWLTIRRLRAAVPTAFAELDWFPYWDPDPRTGEALAARGAEFHYVQMSRAKHLYLLMDTKRLVQHEGVPMAWPIDVDPHWEVPHLGWLAARRAGRAELFYDEVVAARWERGENICDPEVVAGCAERAGLDPAVILGAVDDPQLRAEGVDCLERAYLDDVFGIPYLKWGRHRFWGLDRLDGFLELWRPDAAATVPATVAAPAPATVGLPDRAEAIVAAGGYDTDTTGGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG33</accession>
    <name>F4FG33_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13325"/>
    <dbReference type="EnsemblBacteria" id="AEB43777">
        <property type="protein sequence ID" value="AEB43777"/>
        <property type="gene ID" value="VAB18032_13325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13325"/>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737489_0_0_11"/>
    <dbReference type="OMA" id="LHRQACF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="347" mass="38294" checksum="F9131FFB5C110236" modified="2011-06-28" version="1">MALLPVGFSWHGCCTSQSWESGRRPFTAVPLGQAFAVRRRLGRLGANVTLLAALDDAAEADFILAAVLDGQVDRCDIAEQPLGWCVLTHRLTDLILWAVLGQTPTFARGIPVAHARRGPVASGPALPADEQRAFFTRLHILAERAAAGRDPSVLLHRQACFLAGMDPTRTAAGWLSQTTTRTRRAITFRTWSPLWPDARSVVTSLANQGDPEPLRDFLARAHPDDACERAALNYSAYWVGEIPYRQHDDSFMPAPLADWHGSVLFRHLVQRLNPTHPFVDLNVHNIWALLAVRRRLTLDNPAESRALLKRSTRILDSDHISPQSRQELTSIVYSLRADGVTGTGTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG99</accession>
    <name>F4FG99_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733692.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19675"/>
    <dbReference type="EnsemblBacteria" id="AEB45037">
        <property type="protein sequence ID" value="AEB45037"/>
        <property type="gene ID" value="VAB18032_19675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19675"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_5_0_11"/>
    <dbReference type="OMA" id="RHMKAFR"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19162">
        <property type="entry name" value="AKR_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044477">
        <property type="entry name" value="FDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="13"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="34935" checksum="104F7BC10ED098D1" modified="2011-06-28" version="1">MRRLGNSTVTVSPLGFGAAGIGNLYRTVDEQTAHTALDAAWEAGIRYFDTAPHYGLGLSERRLGAALADRPRAEYTVSTKVGRLLVPSPQTAHLRDEEGGFDVPADHVREWDFSADGVRRSLESSLDRLGLDRIDVVLLHDPDDHWQQAVEQAYPALHDLRAQGVVGAIGVGMNQWQMLHRFVVETDIDTVMLAGRYTLLDQSAQERLLPACQERGVSVLAAGVFNSGVLATEEPGRMYDYRPVPQPVYDRAVRIAATCRRHGVTLPQAAMAFVARHPAVATVVVGVKSVEQVMRNAELLAEPVPDALWDDLAAEGLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHA6</accession>
    <name>F4FHA6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732551.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13860"/>
    <dbReference type="EnsemblBacteria" id="AEB43884">
        <property type="protein sequence ID" value="AEB43884"/>
        <property type="gene ID" value="VAB18032_13860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13860"/>
    <dbReference type="eggNOG" id="ENOG50322PC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2262630_0_0_11"/>
    <dbReference type="OrthoDB" id="2166233at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="103" mass="11251" checksum="B8AA799A02B08FBF" modified="2011-06-28" version="1">MESYHEDWTDSQRALYDECYRCGTDWADDPATPAEDVQHVINLGEADDDTLADAEIDFPPLVDAVTQATGEIVTTVPASHDDPAFKGFVDGVRDATSDEVFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHG9</accession>
    <name>F4FHG9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20205"/>
    <dbReference type="EnsemblBacteria" id="AEB45141">
        <property type="protein sequence ID" value="AEB45141"/>
        <property type="gene ID" value="VAB18032_20205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20205"/>
    <dbReference type="HOGENOM" id="CLU_2319320_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="99" mass="10363" checksum="DBFA60D4C1D533A2" modified="2011-06-28" version="1">MRAKEEPYRSYDMGEHGETRVGPALRPGILSGFVGAGLVDGAVIIGPDGDLSCAGLVLRFDIGDLVVGTLGDEWVLAVGSIPTAVAPYWTMQPFVRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHK3</accession>
    <name>F4FHK3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20375"/>
    <dbReference type="EnsemblBacteria" id="AEB45175">
        <property type="protein sequence ID" value="AEB45175"/>
        <property type="gene ID" value="VAB18032_20375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20375"/>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_7_1_11"/>
    <dbReference type="OMA" id="VAWVGSE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="477" mass="49023" checksum="9EF2D5E67EC4255E" modified="2011-06-28" version="1">MVDLAGALVTPAFVDAHVHVSDTGLALSGLDLSGVRSAGELLDAVSAFAAGLPADAVVLGHGWDESTWSVPQPPSAVELGRAAGGRRVYLSQASIHSALVSSALLAACPQAAAVSGYDGSGWLRLDAHHVVRAAARASVTRAQRMAAQRVALAHAASLGIAAVHECGGPEISDEEDFTGLLSISGAGVPEVYGYWGELGGAARARELGAVGAGGDLFADGALGSRTAFLSQAYVDGDGCGHGYLSAEQVRDHLLDCAAHGMQGGFHAIGDAAISTVVAGFAAAAQRLGTDRVRAARHRVEHAEVMDRRLIAAFVEYGVVASMQPAFDRLWGGAGRMYEARLGLARSLASNPMGAMHGVGVTLAFGSDSPVTPLDPWGSVRAAVAHHSPVQRMTVRAAFAAHTRGGWRAVHMDSEGVLALGAPATFAVWSTPAGVQRGLPVLQAEDPELRGEQDPTPLPVCRATVLRGDVIYEGEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHN5</accession>
    <name>F4FHN5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735055.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26646"/>
    <dbReference type="EnsemblBacteria" id="AEB46404">
        <property type="protein sequence ID" value="AEB46404"/>
        <property type="gene ID" value="VAB18032_26646"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26646"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042538_4_2_11"/>
    <dbReference type="OMA" id="ESRFMEN"/>
    <dbReference type="OrthoDB" id="1869158at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="34149" checksum="0CFE712C1EDA24CA" modified="2011-06-28" version="1">MRTLALSVLHEPPFTTTQHGDTEVVARESAAWAQELGLISNGQRLHRADAAGLASRACPQAPRDRLRLLSDLITWLFVMDDACDEDGLGNDPTRLSPTAAALLDVLDLHGGPGTVPAAGPLGLALADLCRRVRAYGRPAVMLRFTAAMREYLLALLWEAANREHDRVPPVHEYVQMRRHTGGVFPSLALTDLALDGLPPAERRADPQWAALELIAANLICWCNDVFSYRKEHRTGPDAHNLVTVLSRETGDERAAMRAAAARFNHELGTYLSTESNLLAQHGDAVRPALTTRRNWIRATYDWSLAAERYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHU1</accession>
    <name>F4FHU1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Substrate-binding region of abc-type glycine betaine transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02750"/>
    <dbReference type="EnsemblBacteria" id="AEB47634">
        <property type="protein sequence ID" value="AEB47634"/>
        <property type="gene ID" value="VAB18032_02750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02750"/>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731353_0_0_11"/>
    <dbReference type="OMA" id="CPERPFC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="115"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="32132" checksum="8A7EDD32FDE9B64B" modified="2011-06-28" version="1">MLAGCGEAGSSGTEAPQQSASGEGCAPVAGEQLIALTDDKALQNADNIIPAINTKVATPQLVAALDKVSAVLDTPKLVQLNKAVDVDRKSAQAAAQEFSAANGLADGVEKGSGGKITVGAGNFTESEIIAELYKIQLTAAGYQVTVQQIGNRELYEPALEKGEIQVVPEYAATMAEFLKGKTGGGSDPVSSPDVEKTVTALRGLGEQVGLSFGQPAPAQNQNAFAVTKEFAEKYGVRTLSELAAKCSGTATVLGGPPECQERPFCKPGLEQTYGLSVGSFSSLDQGGPLTKTGLRNGTISVGLVFSTDAAYATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI11</accession>
    <name>F4FI11_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03100"/>
    <dbReference type="EnsemblBacteria" id="AEB47704">
        <property type="protein sequence ID" value="AEB47704"/>
        <property type="gene ID" value="VAB18032_03100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03100"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_6_0_11"/>
    <dbReference type="OMA" id="NERHVEW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="90"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="395" mass="43002" checksum="AD7F800785412466" modified="2011-06-28" version="1">MGVDVVLVHQPGQYEESIRQHCEQIVHAPLADGPAMLEVLRPLHEERPFDRVLTVSEPWGVPTGHVVDGLGLPGTTERTARLLKNKALMRERLAKYDLSPVRYRVVRSEQEALDFLAEIGGPVVLKPIDGAASRHILRVDDAAGLRDAWRRHTEAGNTSVLAEEFLAGPVVSVESFSFGGRHLPVGYSEYLVNSHHVEWQVSVPSRLAAAHLTELRDLTVRLLDAVELTEGPSHSEFVLTDRGPRVLESHARLGGHAIPELVRRAYGLDLARMWLTVPLGIDELPAEAPQPSAGAAIRFLRPEPGKIRDITVAEDIPAVVKRVPPGELADVYLPLLGELVDVPVGAVVHKNPGDVITPIHTLADCSSGYVLATGADADAAVDTCVLVDEKIRFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F114</accession>
    <name>F4F114_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07740"/>
    <dbReference type="EnsemblBacteria" id="AEB42668">
        <property type="protein sequence ID" value="AEB42668"/>
        <property type="gene ID" value="VAB18032_07740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07740"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_4_4_11"/>
    <dbReference type="OMA" id="TIGCSGV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="109" mass="12103" checksum="70D5179CFF3733CD" modified="2011-06-28" version="1">MLCGILFVLYTAIPWEYLPQELGFGSGMTCWRRLRDWNDAGVWQRLHEVLLGRLRAAGQLDMSRAVIDGSHVRALKGGPKPVRARSTAASQARNTTSSPTRAVSPSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F188</accession>
    <name>F4F188_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase HrpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_14060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732591.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14060"/>
    <dbReference type="EnsemblBacteria" id="AEB43924">
        <property type="protein sequence ID" value="AEB43924"/>
        <property type="gene ID" value="VAB18032_14060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14060"/>
    <dbReference type="eggNOG" id="COG1643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_3_3_11"/>
    <dbReference type="OMA" id="YERVTLY"/>
    <dbReference type="OrthoDB" id="58588at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="91"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="300"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1352" mass="151296" checksum="F7E62091D698FA95" modified="2011-06-28" version="1">MQNPVSPAATDPIRALQRRLPPLMFRDQRQLRRRLDGVRRLRDPQRRESALAEIAAEVAVAEGRLERRRAALPKITYPPALPVSERKDDIAEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGISGLIGHTQPRRLAARTVADRIAEELGTELGDVVGYKVRFTDQVSEQSLVKLMTDGILLAELQNDRMLRQYDTLIIDEAHERSLNIDFILGYLKQLLPRRPDLKVIITSATIETDRFARHFAGPPTEEHPEGVPAPVVEVSGRTYPVEVRYRPLVEVADTDEEEADEENVRDQIQAIGDAVEELAAEGPGDILVFLSGEREIRDTADALGKLVQNKRSLLGTEILPLYARLSVAEQHRVFAPHSGRRVVLATNVAETSLTVPGIKYVVDPGTARISRYSQRLKVQRLPIEPVSQASANQRKGRCGRTSDGICIRLYDEQDFLSRPEFTDPEILRTNLASVILQMTAIGLGDIAAFPFIDPPDRRNIADGVNLLHELGALDPTETDLDRRLTALGRRLAQLPVDPRLARMVLEGERNGCATEVMVIAAALSIQDPRERPADKQAQADQAHARFADKESDFVAFLNLWRYLREQQKDLSSSAFRRMCKAEYLNYLRVREWQDIVSQLRQVLRTADSEGRGRGRRGADDDAPRGGGRRQSGADLPEEIDTPKVHQSLLPGLLSHVGLKDAQKNEYLGARGAKFGLFPGSALFRKPPRWVMAAELVETSRLWGRVNGRIEPEWVEPLAQHLVKRSYSEPHWEKKQAAVMAYEKVTLYGVPLVTSRKVNFGRIDPVLSRELFIRHALVEGDWSTHHQFWRDNERLRTELEELESRARRRDILVDDETIFQFYDERIPADVVSGRHFDTWWKKTRRERPDLLTFTRELLVNAGRGGVDEADFPDRWHTEGVELPLTYTFEPGSPADGVTVDIPLPLLNQVPAESFDWQVPGLREELVIALIRSLPKPVRRNFVPVPDFARAALAAITPGEEPLLDALTRQLRRMTGVTVPREAWDLGKLPAHLRVTFRVRGDDDKPVAEGKDLPALQRQLKAEVRQVVAAAAPDVARTGLTGWEIGTLPRTIEQIRAGYAVTAYPALVDEGATVGVRVFDSPGEQEAAHWAGTRRLLRLTVPSPAKFLQGRLSNEAKLALSRNPHGGVQALIEDATGAAIDKLIGDAGGPVWDAEGFTALRDKVRADLVDTVVEVMERVRAVLAAAYAVQQRLGATRNLAVVAALADIRNQLTGLVHAGFITEVGYARLSDLLRYLTAIERRLDRLPGNPPRDKQLQDRIAVVQREYDEMLAVLPPARRDSVAVRQIRWMIEELRVSVFAQALGTPYPISEQRIYRAMDDAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1A2</accession>
    <name>F4F1A2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732605.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14130"/>
    <dbReference type="EnsemblBacteria" id="AEB43938">
        <property type="protein sequence ID" value="AEB43938"/>
        <property type="gene ID" value="VAB18032_14130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14130"/>
    <dbReference type="eggNOG" id="ENOG5033H6F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180533_0_0_11"/>
    <dbReference type="OMA" id="RDHSLFE"/>
    <dbReference type="OrthoDB" id="2078786at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045924">
        <property type="entry name" value="DUF6343"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19870">
        <property type="entry name" value="DUF6343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="87" mass="9570" checksum="5DA510C2E51C5E2D" modified="2011-06-28" version="1">MTRSQPRRARGTVGHANSALNLRLVLASFGLVTMVVFAVLAFRAELAWLGVACVIFAVVAVVDLAVIQRRRAARRREEPGARHSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1C9</accession>
    <name>F4F1C9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14265"/>
    <dbReference type="EnsemblBacteria" id="AEB43965">
        <property type="protein sequence ID" value="AEB43965"/>
        <property type="gene ID" value="VAB18032_14265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14265"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388143_0_0_11"/>
    <dbReference type="OMA" id="YDMIPLP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="168"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="336"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="687" mass="73415" checksum="4937FEC9B9348F92" modified="2011-06-28" version="1">MPGVTGMVSRHQWSGSRLGPPEYWDLAVRAAAEIVLASPAPMVLHLSDEFFLLYNDAYAELIGDKHPQALGQPAPQVFADIWPMPGIGDVVEHTYRTGEPFLEREMTLPLRRANGQLDQVVYVRACSPVRDSRGRIVGVLSVITETNPAIRQLQGISELAAALSGTLTLDDVARVALRYAITSFDADRVSFAVDDGGGWRLARRVRGELVDEADERLPPLWRRGPADWPAPAVVSARTGRASYTDDGEPLREVAADRHDQKIRSLATVPLSAAVVRGALTVGYRSPHSWSAQERVLLAASAELVGQATERARRFETQHGTAQLLQRSMLPENLPGLPRLRIAARYDPGVDGNAAGGDFYDAFVLPTGELGVVLGDVAGHDVQAAARMGQVRAALRALALNEPRPDQVLVGLDRLVSSLGAEAGTHELFVTVAFGVIDVARELLTLASAGHPAPLIRRCSADGEPRAEYVQVPAGAPLGVGYQPATCTVAFPPGDTLLLFSDGVVERRRQGLTHGLARLAESVGAAHSGDPRALCATATAAVPGATEDDVAVLAVEYALRPSRSARMEVPAEPTAPSRVRHWMTAQLTEWQVAESVIGAAVLCTSELTTNALLHAGTAARVEIDLSPERLLVSVADSGSRGTVTRTRTDTLSSRGRGLGLIEELSDAWGTDPTVRGSTVWFEILTPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1E4</accession>
    <name>F4F1E4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14340"/>
    <dbReference type="EnsemblBacteria" id="AEB43980">
        <property type="protein sequence ID" value="AEB43980"/>
        <property type="gene ID" value="VAB18032_14340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14340"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_11"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="207"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="401" mass="43349" checksum="654BE7D30C1AEAC1" modified="2011-06-28" version="1">MISEHASPLAILGGEDAGGQNTHVAELSAALAAAGHDVRVYTRRDAVDLPVLVRSPDGYDVVHVPAGPAEPVAKDALLPHMRPFGAWLVDRWRGGDWTPEVIHAHFWMSGLAALQAGRALGIPVVQTYHALGTVKRRHQGVQDTSPARRIGYELHLGRCVDRVIAQCRDEVGELVRMGVPRSAMTVVPSGVNLGTFAPLGPTAEREPDRPRILTVGRLVERKGFQTVVRAMAHVPEAECVVVGGPPAGLLETDPYARRLRALAGSCEVADRVRLVGAVPREEMGRWYRSADILVAAPWYEPFGLTPLEAMACGVPVVATAVGGLRDTVVDGVTGDLVPARDPRALGEALRRLLDDRIRRFAYAGAARARARQHYSWTVTAERIAEVYAEVVAVRRPTRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1G5</accession>
    <name>F4F1G5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20470"/>
    <dbReference type="EnsemblBacteria" id="AEB45194">
        <property type="protein sequence ID" value="AEB45194"/>
        <property type="gene ID" value="VAB18032_20470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20470"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_11"/>
    <dbReference type="OMA" id="HAMVVGT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="32818" checksum="6698A63E85D02897" modified="2011-06-28" version="1">MDLRRLRFLREFEERGTLAAVAAALGYSPSTVSQQLTLLEREVGAPLLTKAGRGVRLTDAGRLLAQHARVLLSAAETAAADLAALSGDIRGTVRAGGLQSAARRLLVPALVRLRADHPQIQVEIFELELEQALPSLRLGAVDVVIGDEYDGHPRPRPAGLRFTLLLEEPLKIVLPAAHPLARTGGPVAVADLRSEVWAASAEGTGHHAMVVGTCRALGGYEPDLRHRASDADVQLELVRAGAAVSLMPALTLPGDDPALAIRDIAETALKRRLVAATRDTPAAPALTTFLAALTDQVHRIGLNSPASAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1I0</accession>
    <name>F4F1I0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20545"/>
    <dbReference type="EnsemblBacteria" id="AEB45209">
        <property type="protein sequence ID" value="AEB45209"/>
        <property type="gene ID" value="VAB18032_20545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20545"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009266_0_0_11"/>
    <dbReference type="OMA" id="APYWRLD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313491" evidence="2">
        <location>
            <begin position="30"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1065" mass="110757" checksum="C71EB57C4896D71E" modified="2011-06-28" version="1">MRRARGTKGLLLAAAGAALVATVALTGLAAYNRDVVDSGTRNVLAAATPQERSVLIRSSAGRTADALQERDTALREQVRVDVDGLAARVTSAGYAAGRQLRGDAGDATADRTGSIYASVMFLDDLPEHARLTAGAWPQAGSARPETALAAAAAATLRVGVGDRIPITDGLTERVTEVTVVGVFTPVDPDAAYWRLAPETATGSLPQAATYGPMIVHRDDFVTHFLANASAGWLVEPDLSTIRTTGELDRLAQVATRIVTTTTAQAGLGDSAVAISDLASLVPRLQQATLVGRSALVTPMLLVVVLGGYALLLVAVLLTEHRRGETALLRARGASRWQLAGLTAREATLVVLPAAVLAPLLVTELLGLAGHLPGLAAVSLRPDVSLDAMIWLVAGAAAAGCALAMIGPSLRRGGSYVADLASRSRPSRRGMVQRAGLDVLLVGLALLAWYQLSRYSSPLSRSRGGELGIDPLLAAAPTLGVLAGAVLALRLLPPLVRLAERWVDRRPWTATMLGTWQAGRRPHAGPVLLLALAVAVGTLAWSLASTSRQSLDDQAAHQVGADLRLTETDGSAPDDRADRLAELPGTTAVLAGWRDRLRVGPDLQPLTVLAWDAESAGEVVRIRPDLADGSADTLFDGLTAGRVTAPATPLPAGTRQLTGQLRTRIDHPFGAVAPVRHHAVLSGPGNGYRRVLLGVTGNGDRLPFSVELPAADTPWRLVGFTVETAGSDRITIDWQLSDLRASRDASRGEPVDLAADGPWRMVNPSGPVAAPRATGNTLKVSYVGGQGADIYARGKTLRLGISRPAAGGLVPAVATPQALSALRRDIGTQTQLFLGGADVDLTMVDTMVAAPGDTDDAALLVDLPSLATRLFHDYGIVRPPEEWWLATRPGQAEQAANAAAALDGLTVLNRERVADELARDPFGVGARGALFAAALAAVLLAAVGVAVDVSATARRRATELAVLHTLGAGHRLVARSLLAEQSFLAGMGVLVGLAVGVGVAATMAPLVILTPSAERPHPPPLLSVDWPPVVATGAGLLLLALTFSAAVSATMRRRLTATQLRIGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1V9</accession>
    <name>F4F1V9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735184.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27306"/>
    <dbReference type="EnsemblBacteria" id="AEB46534">
        <property type="protein sequence ID" value="AEB46534"/>
        <property type="gene ID" value="VAB18032_27306"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27306"/>
    <dbReference type="eggNOG" id="ENOG5032T1U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159912_0_0_11"/>
    <dbReference type="OMA" id="WRRAPFV"/>
    <dbReference type="OrthoDB" id="1965661at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="102" mass="10413" checksum="84D8FE3079D8BA5B" modified="2011-06-28" version="1">MLIAVIVALAVGTYAFRVSGVLLRDRLDLPTWARQLLPVAAAALLAALAATAALTEGAGFAGWARPTGVLVGVVLAWRRAPFVLVVVAAAGTTALLRLLGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F299</accession>
    <name>F4F299_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08350"/>
    <dbReference type="EnsemblBacteria" id="AEB42788">
        <property type="protein sequence ID" value="AEB42788"/>
        <property type="gene ID" value="VAB18032_08350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08350"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OMA" id="WFKRERN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="288" mass="30959" checksum="8AC50C80F50779BC" modified="2011-06-28" version="1">MVDTLETRELRYFVAVAEELHFSRAAQRLGIAQPPLSRAIAQLERRLGVTLFERDRRGVTLTGAGQVLLDEARAILDATTAAARRTRRAASAPDRLALATKAGANHELLRKLLDAHAAQPGAAEVDVLLCGMGDQARMLRDGRADAALMQRPFDDLAGFDTEDLLTEQQVAILPAGHPLAARTSLTMAEIGDVPDLPVARWPRQDGSYEPGPGPEIHDQAQLAQLIALGRTMAVLCASSRSWLWNAHAAVPLTDSPHVTTVLAWPSHSRSRAVAGLVRTAARQVPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2C0</accession>
    <name>F4F2C0_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AEB43992">
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        <property type="gene ID" value="VAB18032_14400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14400"/>
    <dbReference type="eggNOG" id="ENOG50325RP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_215953_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="39" mass="4147" checksum="8678ECFA5FAE280C" modified="2011-06-28" version="1">MELLLADATNAADIPGVRLLGLVVGGLLLLLAIRAMFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2C2</accession>
    <name>F4F2C2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14410"/>
    <dbReference type="EnsemblBacteria" id="AEB43994">
        <property type="protein sequence ID" value="AEB43994"/>
        <property type="gene ID" value="VAB18032_14410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14410"/>
    <dbReference type="eggNOG" id="COG2388">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132888_0_2_11"/>
    <dbReference type="OMA" id="GYAEYQD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="98" mass="10696" checksum="32A67B86A8D8BF4F" modified="2011-06-28" version="1">MGGVSMLVEENAAKHRYEILVDDALAGFTAYLPRGEALVFTHTEVDPAFQGMGVGSALMRGTLEQVRAQGQRIVPQCPFMAAFIKRHPEYADLVTSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2C4</accession>
    <name>F4F2C4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732663.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14420"/>
    <dbReference type="EnsemblBacteria" id="AEB43996">
        <property type="protein sequence ID" value="AEB43996"/>
        <property type="gene ID" value="VAB18032_14420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14420"/>
    <dbReference type="eggNOG" id="ENOG5030WMB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073530_1_0_11"/>
    <dbReference type="OMA" id="EQTWSAY"/>
    <dbReference type="OrthoDB" id="1522739at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="111"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="202"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="29397" checksum="E63DF9595EF0A91C" modified="2011-06-28" version="1">MSLTRNAEATAARTADSRWLELLARAGFIGYGIVHLLFGWLVLQLAFGKSADDGDQSGALRTLAAQPMGKFLVIAIAVGMLAMAIWQALEAAVGHHAAQGNDRTKERVVSAARTVIYLWLAWTAWKVFSNANSDSASQQEELTARMMESSGGRWLVGLAGLVLAGVGVGMVIYGAKKKFMKRLKTGEMNARTTQLARRLGMAGYISRGSAFAVTGLLVVLAAVNYDPEKARGLDAALRTLRDQPFGTILLILIGLGIAAFGVYCFLQSRYRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2E1</accession>
    <name>F4F2E1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine triad (Hit) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14505"/>
    <dbReference type="EnsemblBacteria" id="AEB44013">
        <property type="protein sequence ID" value="AEB44013"/>
        <property type="gene ID" value="VAB18032_14505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14505"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_1_1_11"/>
    <dbReference type="OMA" id="YNPGHVM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="170" mass="18783" checksum="9791ED4FC126B269" modified="2011-06-28" version="1">MADGLDRLWTPHRMTYISGEDRPEGGYEQPSGCPFCLAPGRPHEESLVVARGEHVFVVLNLYPYNPGHLLVCPYRHVADYTDLDEPETVELAAFTQTAMRVVRKVSNAHGFNLGMNQGGVAGAGIAAHLHQHVVPRWGGDANFMPVIGRTKVLPQLLSDTRDLFVRAWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2I1</accession>
    <name>F4F2I1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ordered locus">VAB18032_14705</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732720.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14705"/>
    <dbReference type="EnsemblBacteria" id="AEB44053">
        <property type="protein sequence ID" value="AEB44053"/>
        <property type="gene ID" value="VAB18032_14705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14705"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_0_2_11"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB44053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="18420" checksum="CE75DAEB3C8BE403" modified="2011-06-28" version="1">MRVLGVDPGLTRCGVGVVEGVPGRPCTLVAYYVIYTDPADELPTRLLHLDRSLTDLVAEHRPDSVAVERVFSQHNVRTVMGTAQASGIAVLAGARAGLPVQTYTPSEVKAAVTGSGQADKAQMTAMVTRLLRLSEPPRPADAADALALAICHVWRGGTRSKLAAAADRARRGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2J0</accession>
    <name>F4F2J0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase cyclophilin type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732729.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14750"/>
    <dbReference type="EnsemblBacteria" id="AEB44062">
        <property type="protein sequence ID" value="AEB44062"/>
        <property type="gene ID" value="VAB18032_14750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14750"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_8_1_11"/>
    <dbReference type="OMA" id="TTCHEIT"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="100"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="299" mass="30941" checksum="4B7C4F04AD754C9B" modified="2011-06-28" version="1">MASSRDRQRKLARAKLDRQMARRAAALRRRRQIRAGVGTALILVLVVAGSAWALGAFDREPTEDTAAPEVCLWTPQNTEGNSNLKDVGEPATTGLPTTGTRPMTVTTNQGAPISIELDLAKAPCAAASIAHLASQSFYDNTNCHEITADGAVRCGDPSGTGLGGPAYSFYSENVPTAPESSPAPATEPPTYPKGTVAMISSPPGANSSQFLIFFKDSISHEPAYPIIGRVTGGLDVVEKIGALPTVDNEAGQKVKPENDVVIQSLTVGEPVLDPASPADPTGTPSPAVSGSTEASPNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2J7</accession>
    <name>F4F2J7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44069">
        <property type="protein sequence ID" value="AEB44069"/>
        <property type="gene ID" value="VAB18032_14785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14785"/>
    <dbReference type="HOGENOM" id="CLU_3278338_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="41" mass="4552" checksum="1ADC72D117A8969D" modified="2011-06-28" version="1">MLRYLVPAHTRAAHQIDMRRRVNGGTHAGGPPEEEFGGPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F332</accession>
    <name>F4F332_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736443.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03645"/>
    <dbReference type="EnsemblBacteria" id="AEB47811">
        <property type="protein sequence ID" value="AEB47811"/>
        <property type="gene ID" value="VAB18032_03645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03645"/>
    <dbReference type="eggNOG" id="ENOG5033RSJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873277_0_0_11"/>
    <dbReference type="OMA" id="AVHWGAV"/>
    <dbReference type="OrthoDB" id="894977at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="35860" checksum="62FE6CD3107976CD" modified="2011-06-28" version="1">MAATDRRDVPLGADPAANRHAIERLLADGAGGTLHLPAGTFPLDGGIVVGAGWTLAGAPQHDGPVRTWLTSSASDGQPIVHVLGSQVTIQDIGFRPPPVSPGEHGGDRGTAITVGSYLYPAEAEWIEGIQLRRVRVERPDTRAANCIALVGAVRHLTLADVSIVGGCTGIAVHWGAVGDSVSSISGPSYHPHHIDIQDLVVSDAFEGFYLSSVHDVSVRRARLSDVEIGFRLLPGDNTDRFHVGDDDVIGQRIRVSDARVSWNGPLYAIRIAGWGRSEVDHSVRVLEYRDVVVTDCTLVPLPVIGAKDPLRSRTPVVVEQASGVLLDSIRVDLRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F371</accession>
    <name>F4F371_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736482.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03840"/>
    <dbReference type="EnsemblBacteria" id="AEB47850">
        <property type="protein sequence ID" value="AEB47850"/>
        <property type="gene ID" value="VAB18032_03840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03840"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048112_0_0_11"/>
    <dbReference type="OMA" id="RKRAIFH"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="236"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="467" mass="52015" checksum="D58C1D7E94C537E4" modified="2011-06-28" version="1">MSSYDVRIHAILTNELSGRKKSYTVRWKVAGKPFRNTYATRALAESFRSKLVVAQREGTAFDEKSGLPEPMARELNSRNWYDLAVAFVDMKWPRAAATQRKSIADALTTVTLALLATSRGAPDDAEIRHALYTWTFNKLQRDRDNGQPPENLAPAVRWLTANTLPLSDVANPATIRKALDALTVRIDGGPAAANTVARKRAVFYSALKYAVELRYLDAHPMDSIQWRAPKNTDQVDRKVVVNPEQARSLLSAVRQRDPHLEGFFACMYFAALRPSEVIHLRADECELPESGWGWLHLSGSTQQVGEDWSDSGRSLEDRELKHRAKKATRDVPACPELVRILRHHAREHCRDANGRMFNAAGARPAPVSKSTYLRAWRQAREAALTPAQQRSPLAHRPYDLRHAAVSLWLNAGVPATQVAQWAGHSVHVLLKVYASCIDGQDEAARKRIEGALGTDDQAENAPGDADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3B5</accession>
    <name>F4F3B5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basic membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08605"/>
    <dbReference type="EnsemblBacteria" id="AEB42839">
        <property type="protein sequence ID" value="AEB42839"/>
        <property type="gene ID" value="VAB18032_08605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08605"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_0_11"/>
    <dbReference type="OMA" id="LASMMKR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="34"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="350" mass="35783" checksum="5A158F0CB15C4A65" modified="2011-06-28" version="1">MIAAGGLVLSAAACGEAPDEDNNAGSGGEKYSACMVTDVGGIDDKSFNASAWKGLEAAKAENSNVDIKYVASRAEADYEPNLSAYVNQDCDFILAVGGLMGEATKKIAEANPNQQFAIVDANPGVANVYPMEFDTAQAGFLAGYVAAGMSQSGKVGTYGGMKIPPVTIFMDGFVDGVAHYNQAKGAKVQALGWNKETQNGSFTNDFVKQDEGKKVSDALVAQGADIVMPVAGGAGLGTTGAAKASGGKYNTIWVDVDGCESTPDCSAIITTVVKNIPGAVKEAVLKAAGGEKLSAEQGFVGTLANDGVSLAPYHEFDSKVPAELKAEVDKLKADIAAGTVKVESAAQPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3D3</accession>
    <name>F4F3D3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_08695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731528.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08695"/>
    <dbReference type="EnsemblBacteria" id="AEB42857">
        <property type="protein sequence ID" value="AEB42857"/>
        <property type="gene ID" value="VAB18032_08695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08695"/>
    <dbReference type="eggNOG" id="COG4987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_11"/>
    <dbReference type="OMA" id="FLSGYMI"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="43"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="369"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB42857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="618" mass="62734" checksum="7AB181C3972882F0" modified="2011-06-28" version="1">MSEERSAQAGPATGSTQAGLRTADGAPELVVLRLARPYLNRLIGAGLLAAVTEFAALALMATATWLLMAAAGQPPLDRLTVAIVAVRALAVSRGVLRYTERLAGHDAVLRLVTDVRTRVFATLAARRGAPPRTGDALSRLVSDVEAVQDLLLRVVVPGAAAGLVSVLAVGLTALVSPSAALVLAAGLLVAGVALPALATALTRRAAAEVAPLRGALAADAVDLTHGAADLAAFGTTGVALDAAQRRARRLARLERRLAVRGFAVDAAGVLVAGLTAGAVVFVALRAGVGGVLVGVLAVGTLSAVEIALALVGAARQWTALRAGLARVAPLITDSATTGAGPTGVERTSPEPAPAALTALSGNRGSAPDLRFDQVTVQYRSGAPAALDTFDLDLPAGRRVAVVGPSGAGKSTLAAVLTGAVRPDGGRVTLDGRDLGTYSPEELPTVVGGLLAEAYVFHATVRENLLLGRPGADELALFAAAEAAGLADWVRDQPDGWDTVVGEEGAQLSGGQRQRLALARALLAAPAVLVLDEPTEGLDPVAADEVLAGALAAVPAGRSVLLISHRLSGLAGLDEIVVLDAGRIIQRGRHEDLIATPGWYRDQWTLQQAAEHGYLAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3I9</accession>
    <name>F4F3I9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732764.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14925"/>
    <dbReference type="EnsemblBacteria" id="AEB44097">
        <property type="protein sequence ID" value="AEB44097"/>
        <property type="gene ID" value="VAB18032_14925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14925"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_5_11"/>
    <dbReference type="OMA" id="SHYAYEY"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="33868" checksum="8E0D3B2301080A5D" modified="2011-06-28" version="1">MTAYPSVTAVVPTRDRPELLRAAVRAIVGQDYPGQVETVVVYDQSEPDPSLAELSAADRPVRVVTNTRTPGLAGARNSGTMAATGELIAFCDDDDEWLPGKLAAQVDALNAVPGAEFVSCGIRVSYDGHTVERVLERDSISLADLLRDRMTELHPSTFLIRAAALRDGFGLVDEEIPGSYAEDYEFLLRAARSAPLVNLRTPYVLVRWHKRSYFAQRWDTISEALQWLLERYPEFATQPAGQARVTGQIAFARAASGDRRGAMRWARRTLRRNPREPRAYLALAVAGRVVRADAVLRTLHKRGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F408</accession>
    <name>F4F408_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Respiratory-chain NADH dehydrogenase domain 51 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_27906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27906"/>
    <dbReference type="EnsemblBacteria" id="AEB46654">
        <property type="protein sequence ID" value="AEB46654"/>
        <property type="gene ID" value="VAB18032_27906"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27906"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_0_11"/>
    <dbReference type="OMA" id="NGPSRQK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_51K" evidence="6">
        <location>
            <begin position="56"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="NADH_4Fe-4S" evidence="7">
        <location>
            <begin position="321"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="488" mass="51160" checksum="0586E0DE364DD2BD" modified="2011-06-28" version="1">MTMRTTVPPVACVGEPRITAGFAEFGRLDLRAHEMVHGPISPMEPSSLLRLAEGIQLKGKGGAGFPFARKLRAVLESCERQDLPPVVVVNATEGEPASWKDKVILTRAPHLILDGAALAAFALDAEEIVLCVADDLIGRDSLMEALEERRMPVPTSVVTVPHRFISGEGGALVNGINGLPHIPPGTKKRSSDSGVNNLPTLLSNAETYSQMAIAARLGPYEYAALGTDDEPGTVLLSITGAAKRHAVVECAAGTPLREILELCEVPEGPGILMGGYHGKWITWEAANKAEVSRKGLAAVGGTLGAGIIVPLANDTCPLGEAAQVVRYLAGESAGQCGPCKRGLPDLARAVDLAVSGSAPVEVVRAAAGDVKGRGACSHPDGTSRFALSAMEVFAEDLKKHTTGEGCGRRVKGVMGLPGAPDPDPQKLVLDWSRCDGHGLCAHVVPDFIRLDQNGYPAFPPTPVPTWLREGASKAVKVCPELALRLTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4A5</accession>
    <name>F4F4A5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fructosamine/Ketosamine-3-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fructosamine kinase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AEB47918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
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    <dbReference type="STRING" id="263358.VAB18032_04180"/>
    <dbReference type="EnsemblBacteria" id="AEB47918">
        <property type="protein sequence ID" value="AEB47918"/>
        <property type="gene ID" value="VAB18032_04180"/>
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    <dbReference type="KEGG" id="vma:VAB18032_04180"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="1457558at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="32977" checksum="5AE501835C94F707" modified="2011-06-28" version="1">MDLAYLRAHPEQLPTFLTHQRIRETPVGGGDICAASRLTLDDGHSVFAKTWPERAQRPVPEGFFATEAAGLRWLREAGTVAVPEVLVALPDLLALEWIEPGEPSVDAAERFGRELAGLHRARASAFGASWPGFIGALPADNTPHDGPWADWFARTRLLPYLRHSVDNQALDARAAGLVEEVVARIGEFGGEEPPARIHGDLWPGNLIWGADDRVWLVDPAAHGGHRETDLAQLALFGGPPHGARIMAAYDESWPLADGWRQRVPLHQLHLMLVHTALFGAAYRDSVVGLARATLSGAGRATVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4H7</accession>
    <name>F4F4H7_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">VAB18032_09085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AEB42935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AEB42935"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="31" mass="3325" checksum="9B5711C3DE79EF7A" modified="2011-06-28" version="1">MVAALRQIDAALAPYTTLPSSRSRGTRHARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5E9</accession>
    <name>F4F5E9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_09315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09315"/>
    <dbReference type="EnsemblBacteria" id="AEB42981">
        <property type="protein sequence ID" value="AEB42981"/>
        <property type="gene ID" value="VAB18032_09315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09315"/>
    <dbReference type="eggNOG" id="COG0189">
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032794_0_0_11"/>
    <dbReference type="OMA" id="NRVYVRC"/>
    <dbReference type="OrthoDB" id="221126at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017534">
        <property type="entry name" value="GNAT-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03103">
        <property type="entry name" value="trio_acet_GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="147"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="367"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="626" mass="66828" checksum="080AB633ACB55718" modified="2011-06-28" version="1">MTDTLATGVARTDRGRGRRYERVGPGGDPIAAGGSADPGEDAERPRDDAGVVLDCGWGRLVFGQTFHDQAAVADILRSEAAGARDICIYLRDPHVLVSRLPDELFIDPSLTYRLPLYGPRADTGTGEQTGSAGTPALTGGPPELPGVRIRRLRDAADADAVNRIYASNGMVTAPVEVLVDNAATDRFLHLVAEVTTGEIVGTITGIDHVAVFDDPDNGASLWCLTVDFNQAPPGTGQALITELAARLVARGRAYVDLSVLAENVGAIRLYERLGFYRTATLCVKRKNPINERLFLPAMPEGYDQLNPYAKIVADEAMRRGIRVEVTDPQWGELRLSTGGRTILTRESLSELTSAVAMSRCDDKRVTRRILADAGLSVPRGRTATGDAADAEFLAEVGELVVKPARGEQGNGITVGVRTPEALATAVELAARYCHEVLLEELCAGEDLRVVMIDHEVVAAAVRRPASVTGDGVHDIAELIERQSRRRAAATGGESRIPLDDMTRDVVAEAGYALHDVLPEGQVLAVRRTANLHTGGTIHDVTGELHPVIAEACVAASRALDIPVTGLDLLVPAPDQPEHVFIEANERPGLANHEPQPTAERFVDLLFPGTRAPQRLWTPAGAAPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5G7</accession>
    <name>F4F5G7_MICM1</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731670.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09405"/>
    <dbReference type="EnsemblBacteria" id="AEB42999">
        <property type="protein sequence ID" value="AEB42999"/>
        <property type="gene ID" value="VAB18032_09405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09405"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242700_0_0_11"/>
    <dbReference type="OMA" id="PQYLPWA"/>
    <dbReference type="OrthoDB" id="338654at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="825"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="904"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1039"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1374"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1485"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1510"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1537"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1562"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1586"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1609"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1644" mass="166241" checksum="79DEF42512BF2F47" modified="2011-06-28" version="1">MATFQCSSCEQEIKPAVRCPRCGAHQPQWAEHLAEIERSIAEMKAREAAIASEQRQLASKMQAAIFQRDTLAHAGNVGDGRTRQAGRPRRVLRRRPAYKSPGAGTVPPTRHKPSDGAPPPPRVPRQGASDGAEELPPTTPIWLDADNPEHPPEASSREVQNIPLGLGALLLGVAAVVFAVLATSSMDALTRLGILLLATVLMLLAPPVLTKRGLTSTAETIAAVGLLLVPLAGYALWAVDRIGGGSGALFAGVIFAVTAAVSVGYAGLTRLRAPRFAAVLAAQPVVPLLAYERISGPAGWALVLTVVAVLDLWLARSPVTVQRPAVDGSTDAAPARAATPRQRTADGRPEGAPEEAGELIDPVVGTPAVAPAQPVPGLRELTWALHGVAVVLALGHAVTALLRTDTVSGAIGAGLVLLLAATVCLAGTLLLRRPPLPDIGAGVLTLAVIGALGRVASVALPGRSLLLIAAVIAVTGLVVRAVPESARRGPQLASAIALTVSGVVVAGSALRAGIAPVEAALPAWAANLDRYPAELAAAAGPAGWQLAASAFLLTVAAVVALPAEIRREFAVTGAALTALAVPASFGLSWSVAPWPMVLTAIGIGAIGLSARTTRAARAHAVAAAVVGLAGAGAALARPALTAAVLLTFVVAGVLIAVAPRIRLAPAAADEISAWAAGGAAFALPGAVAAFVAALRYGEPTLTPASLREATVPVLAASFLAVCVTLGYAAIVQVSQRHIPMPLSVGAGLGALVVAAAGFGAPGATVADAWVSALLLVAAVLLFLAPSIDAGRRSDLTMDGSDLAAAAVTAALVATLLRIGTVLAPGGQLAVAAALVLVVAVAARAMPEQWRRGPVLGLAVGGVLIGLLAGWMALRGGVGVLATSGPIWNGDLSGWPAAPTGGTTWQAPIALALLALSAAILLPPPWRYDVAGVAVVLATIGAPAAFDLAWWSPVVIGGMVAAVVAMTAVASVDPRAALSRITVAGVIALHAAGAGLVRPWTTALALTSVVVIGTVVAALARSMSASLVEDIQAEGMPPHLAQIGGAAVGAALLALPGATAALAAEFGHPPQAILTAGLAATSLGLAVVAGVRGQIPQYLPWASAGVVGGAVVTALAAVPLGLQVGVYAAAAALLGVLAELVREATEPPADPIQPPRRWTVLLDGAIRRTPDDGLRPRWRVSPAAGALGAAALPTLLAVISIAPALSAALVDPIRTLRRVWQGPPPELLDPPAAAVNPTHVLAALLLTATAALAATGFSAGRRSRAVPVVLPGAAITLLIAPIALGSGWPMSTRAALVVFTISMLGLALTPPPSLVERARSLRLARVLVFLIGLAAGGAGLAGSLATRELTLLSLGGAVGVGVVAALFGTTSRARILGWLFASLMAQLFVLTVGLVAGLAAVWSAFGVLAVGAALQVFAARLPRLRRPEARVEAATVEWSGHAAALIALALAFDSPRHIAALLAGWGAVLGVAAMRPGRRPVERRILFWAVVICEITAWWILMWVADVALPEAYTLPFAALALLVGVLELRQRADMSSWVAYGPALVAAFVPTLAIVLATDSSTLRQVLLLLGAVAVLVFGSMSQQQAPVIVGAVVTAIAAVHALFSLGPWLALIPVGFLLLILGASNERRRRAQERLQTALRGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5I0</accession>
    <name>F4F5I0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731683.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09470"/>
    <dbReference type="EnsemblBacteria" id="AEB43012">
        <property type="protein sequence ID" value="AEB43012"/>
        <property type="gene ID" value="VAB18032_09470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09470"/>
    <dbReference type="eggNOG" id="COG3667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893751_0_0_11"/>
    <dbReference type="OMA" id="PAWNQPP"/>
    <dbReference type="OrthoDB" id="2053235at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="370" mass="37657" checksum="294483DAF1EB3CFC" modified="2011-06-28" version="1">MTSPAEPSPHTPPPAGQVTRPLRELAALVLLAANAVFLFVGLIRLVTPQGAYSTVTGRAGSAFFAFIGLEAVVLPLLAVLLATHIAPAVPKAKLITQVALVEYAVSAVLGGLTLLIWMVGRLAEAQIFDALTGMLARTAWVALFGLAAYVVWSIWRRLYHVPRPKAEPGVYGTPQPGWPGNPGQPGGGAGQPWYPGQPGPGGAGQSGYPGQPGSGAGGQSGYPAEGWSSGGWSAGDQPSSAGAGQQTGASAGWPMAGQAPSSESSASPHTWPPHGQPAVPPQSPPSAPQPSAPPFGQPASADATQTIARQSADPTEAIARPTEARSSAEPTEAIARPSEATSSAEPTQALPRPDGDDDRTRRIDLGGQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5K1</accession>
    <name>F4F5K1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_09575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09575"/>
    <dbReference type="EnsemblBacteria" id="AEB43033">
        <property type="protein sequence ID" value="AEB43033"/>
        <property type="gene ID" value="VAB18032_09575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09575"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="OMA" id="RTMDTHV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="224" mass="24361" checksum="29BB8147C5F41E15" modified="2011-06-28" version="1">MHVRVLVADDERLLADTVAEGLRQFSMAVDVCYDGGGALERIGVNRYDVAVLDRDMPVHTGDEVCRSLAESGATTRVLLLTAAAGIRDRVEGLGLGADDYLTKPFAFAELVARVQALGRRSAPAVPPVLRQHGVALDVARHTVTRDDREVNLSPKEFAVLHVLMRAEGRVVSAEELLEQAWDEFADPFTNAVRVTVMTLRKKLGTPQIIHTVPRAGYRIGGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Q2</accession>
    <name>F4F5Q2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS116/IS110/IS902 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15775</name>
        <name evidence="3" type="ordered locus">VAB18032_16910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15775"/>
    <dbReference type="EnsemblBacteria" id="AEB44265">
        <property type="protein sequence ID" value="AEB44265"/>
        <property type="gene ID" value="VAB18032_15775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44486">
        <property type="protein sequence ID" value="AEB44486"/>
        <property type="gene ID" value="VAB18032_16910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15775"/>
    <dbReference type="KEGG" id="vma:VAB18032_16910"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331467_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="206" mass="22703" checksum="C47A9657AB4AD09C" modified="2011-06-28" version="1">MDPHKRSATIEVMAGDETVVGGGRFDTDRDGYTAMRKYAGQWPHRVWAIEGCQGIGRHIANRLLADGEQVVDVPPKLSARARVFATGQGRKTDATDAHSIALVGTRMTGLRPVVNDEQLALLRILVDRRRCLGVDHTRMVSQLHQLLLELIPGGAKKSLSAAQAKTLLATVRPRDAVGKARRRVAAELIADLERIYRRSKEADKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F616</accession>
    <name>F4F616_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase</fullName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734228.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22375"/>
    <dbReference type="EnsemblBacteria" id="AEB45575">
        <property type="protein sequence ID" value="AEB45575"/>
        <property type="gene ID" value="VAB18032_22375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22375"/>
    <dbReference type="eggNOG" id="COG2240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046496_3_1_11"/>
    <dbReference type="OMA" id="CPNQLEL"/>
    <dbReference type="OrthoDB" id="1480223at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="104"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="29633" checksum="BEE9B794C5A51945" modified="2011-06-28" version="1">MKILSIQSSVAYGYVGNSAAVFPLQRLGHEVWPVLTVHFSNHTGYGAWRGPLLAPADVAEVIAGIADRGVLGDADAILSGYQGDPAMGAVILDAVSLVKTANPDAVYCCDPVMGDVGRGMFVRPGIPEYLRDVVVPRADIVTPNQFELEFLAGRRTDSVVDLLAAVDIVRASGPRHVLVTSVLHGAVPAGSLDVVAVSDEGAWAVTTPLLPINPNGGGDVTAALYLAHLRISGSPAIALERTTASIFAVLEATLAAGTRELQLIAAQEAIAHPPNRFPARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6A5</accession>
    <name>F4F6A5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_09665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731722.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09665"/>
    <dbReference type="EnsemblBacteria" id="AEB43051">
        <property type="protein sequence ID" value="AEB43051"/>
        <property type="gene ID" value="VAB18032_09665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09665"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059687_2_0_11"/>
    <dbReference type="OMA" id="QAYRRGC"/>
    <dbReference type="OrthoDB" id="1179564at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05637">
        <property type="entry name" value="SIS_PGI_PMI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="398" mass="40792" checksum="9BD93FEB8E216E51" modified="2011-06-28" version="1">MIDGTAGVSGHRHADDQLLDDPKALAERDPGGMLRHTASAGAQVRESAALAAEANLSMLADDGRPRAVVIAGIGTAGRTGDVLATVAGPRCPVPVIAHRSAGVPGWVGAADVVIAVSASGRSPEALGAAEAAHRRGARLVAVGPADSQLQSLAERARAPFIPVPRRAPARASLWGLTVPVLLAARALGLVKVNEADLAETAARLDADADRCRPTAESFVNPAKSLALGLAGSIPIVWGSSPLASVAARRFGDTLSANARYPVVTGALGEAGRGRVGLLDGVFGGLAEGERDIFADPEESTPDGTRLRLVLLRDGGLNAEDDADEPLAVEERRADAVQTLAERRGVRCDVVTAEGGSALERLASLVAVPDFASIYLALAHGLDPMAVPAITEMKELANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6E3</accession>
    <name>F4F6E3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Magnesium chelatase, chli subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731760.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09855"/>
    <dbReference type="EnsemblBacteria" id="AEB43089">
        <property type="protein sequence ID" value="AEB43089"/>
        <property type="gene ID" value="VAB18032_09855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09855"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043779_0_0_11"/>
    <dbReference type="OMA" id="GMIPRAN"/>
    <dbReference type="OrthoDB" id="325470at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="483" mass="51988" checksum="9F4262A9CB9C2DBB" modified="2011-06-28" version="1">MSRFPATPVPPPDLPGTLGALRAAGCRYRTVKQELRDNLLARLRDGGPRFAGIVGYDDTVLPEVERALLAGHDMVLLGERGQGKTRLIRSLVALLDEWTPVIAGSALNEHPLHPITPASRALVAEAGDDLPVGWLHRSMRYGEKLATPDTSVGDLIGDVDPIRLAQGRTLGDPETIHFGLVPRTNRGIFAVNELPDLAERIQVALLNVLEERDIQVRGYQLRLPLDLFLVASANPEDYTNRGRIITPLKDRFGAEIRTHYPTDLELELALIRQEADLVAEVPEHVLEVLARFARAVRESPSVDPRSGVSARFAIAAAETVAAAALRRASLLADASTAEPFLAPEAVARVGDAVSVTSTLRGKVEFESGEEGREIEILGHLLRTATAETFRARLAGLDLSGFTTLVEDGKAIETGELVPATDLLRQVGTVPGLAKVLDRLGVGDAPSAGQAAAAVEFVLEGLHLSRRLGKDVTDSGRTRYAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6H1</accession>
    <name>F4F6H1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09995"/>
    <dbReference type="EnsemblBacteria" id="AEB43117">
        <property type="protein sequence ID" value="AEB43117"/>
        <property type="gene ID" value="VAB18032_09995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09995"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056518_0_0_11"/>
    <dbReference type="OMA" id="TNNAVFA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="32277" checksum="4B4D901F365D7707" modified="2011-06-28" version="1">MRQIAAELAVPSDDARLLQLTNNAVFALPEAKLVIRIARTHRLHDRVAKVTNLARWFAAINAPTIRLAPVAQEPIAVGGILASVWTYVPSTPPAPTADDLGEALREFHSFPAPPIALPKWDPIGDARRRLADAEGLRQDEHDFLSRWCDRLEPQVATLMRQTPSGLVHGDAHVGNLLREPSGRVVMCDFDATCLGPWPVDLAAVAVGEARFGGAGSHARLAAAYGIDITSNPIWPILREARELKMIAAATPLLASSSAVATEFRRRIRSVQDNNHEARWKPFADLGKLPSHQLPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6N4</accession>
    <name>F4F6N4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_16280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16280"/>
    <dbReference type="EnsemblBacteria" id="AEB44362">
        <property type="protein sequence ID" value="AEB44362"/>
        <property type="gene ID" value="VAB18032_16280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16280"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379884_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="729" mass="78924" checksum="306DF606FDF73FED" modified="2011-06-28" version="1">MPDPDVVFDGRYYYMVSTTMYFAPSVPIMRSSNLVHWSIAGYAAAILDDADALALRKGQDAYGQGSWAASIRFHDGTYYMSVGSLTTQQTYVYSTPNIERGPCSRSVLDGYAHDQSLLFDGDDVWLVYGGGSIDLRRLRRHDDGTLGWDGPATRLVEDANVDQTSGLHAEGAHAYKIGDYYYVFMIEWPSGGVRQEVLWRSPSLTPQSAGGAWEGRVVLSQGVTVGGRPGTGVAQGGIVQTYDGQWYAMLFQDEGPLGRSPHLFGVTCMERVEPGAAVAVKPQPGQPVLVAHRAARTPAADHGQRRVEHPRCAQHAHPTHARTHELRHHLAGRLAHEGRERRRHLRLPAHVRIHRRDDGGRNQEPGDAPGRRRRRHRLHQRTGAAAGGRRLPARGRRLPGCRRYGVVRVLVRRQQLDVWATPCRCGTTSQWDNRLDNTSYGARSGRVAQPGSAKPPGGHGTEGARRVDAGDGGEAPDPIANRVGVHEKVRPGEVDIAVALQPGEHGVRHRFGSRSECRPSGRVPVEQHRCQVCPLGQRRQPGHIGNVDQSGAAGGLGGGQGRGGEPPHRREFLRFGRTGEPRHSPDPLQAGGRSPGQNSDHQVVHGRAQHRRVLAYGSFDAGGGLPGPGDEHPQPVGDRKAGLGGCQRGRRTTLEQPPQQCRVPAPGKRIRAGSGSPMRADQPCPDGLGPVVVKVPDVQQLLGADALGSGEFPGPGPDRALGEVDRAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F734</accession>
    <name>F4F734_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735547.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29136"/>
    <dbReference type="EnsemblBacteria" id="AEB46898">
        <property type="protein sequence ID" value="AEB46898"/>
        <property type="gene ID" value="VAB18032_29136"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29136"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_1_11"/>
    <dbReference type="OMA" id="WAFPAPE"/>
    <dbReference type="OrthoDB" id="1077305at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="185"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="452" mass="47424" checksum="D554369797CDE44A" modified="2011-06-28" version="1">MTLIAERPGPGAARPYRFPQVVRRAVAGGQVVAAHLPGQNLAVALLLLDAGAGREPVGKEGLGGVLAKALEEGTSQRDGTAYALAIEALGTELVTGLDWDTFQASVQVPVERLGAAVELLAEAVRTPKLDPDDVRRVRDDEATALRMDWANPGPRADAVLRADLFGADNRWGRPLYGDPDSVAALDAEDVTVFHSEWFIRPGTLVVAGDLDRIDLDALAATAFAGTGGGPVDRGGPIDVPLRTGRRIILVDRPGSVQSTLRLGHVAPHRAHPDHVPLALAGTVLGGAFTSRLNHLIREVRGYTYGIRGDFASSRRFGRFAVSSGVQTAVTAPALVESVGEIARTQAGGVTEDELAVARSWRAGQLSVELQSPRAIAAALTTLVVHDLPDDYHAQLREALLAADVAQVSAAAATHLHPDSLTLVVEGDAALIRDELVAAGLGEVIDHAPAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F737</accession>
    <name>F4F737_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735550.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29151"/>
    <dbReference type="EnsemblBacteria" id="AEB46901">
        <property type="protein sequence ID" value="AEB46901"/>
        <property type="gene ID" value="VAB18032_29151"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29151"/>
    <dbReference type="eggNOG" id="COG3211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045986_0_0_11"/>
    <dbReference type="OMA" id="RGYVYET"/>
    <dbReference type="OrthoDB" id="796397at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307466" evidence="1">
        <location>
            <begin position="30"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="384" mass="40256" checksum="6E13DDE8EA98295F" modified="2011-06-28" version="1">MDRRTVLRATVAGGAAAFSGSLWAQAAVAAPAQPGPSPYGALRSADANGIQLPAGFTSRVIARSRRTVAGTSYVWHDAPDGGACFTAGTGWIYVSNSEITPGGGASAIRFDADGSIASAYRILSGTNQNCAGGATPWGTWLSCEEVSRGYVYETYPQGGTAAVRRDAMGRFKHEAAACDPDRRVIYLTEDESNGCLYRFRPTSWGSLAGGTLEVLVAGSATSGPVTWARVPDPSGASTLTRNQVSGAKRFNGGEGCWYADGTCWFTTKGDNRVWAYDAVNQRIDLAYDAARVSGSAPLTGVDNITGARSGDLFVAEDGGNMEICVITPDEIVAPFLRITGQSSSEICGPAFSPDGTRFYFSSQRGTSGSPSGGITYEVRGPFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F740</accession>
    <name>F4F740_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735553.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29166"/>
    <dbReference type="EnsemblBacteria" id="AEB46904">
        <property type="protein sequence ID" value="AEB46904"/>
        <property type="gene ID" value="VAB18032_29166"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29166"/>
    <dbReference type="eggNOG" id="ENOG5030DAM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203903_0_0_11"/>
    <dbReference type="OMA" id="FANEHET"/>
    <dbReference type="OrthoDB" id="2050979at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="7116" checksum="3C0590E47DF24A57" modified="2011-06-28" version="1">MSQPTEDHDQTPALAQPPEGRDTLPEPDFANEHETTAVDDDILTGADQDEREPESPRGWSGMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F789</accession>
    <name>F4F789_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731818.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10145"/>
    <dbReference type="EnsemblBacteria" id="AEB43147">
        <property type="protein sequence ID" value="AEB43147"/>
        <property type="gene ID" value="VAB18032_10145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10145"/>
    <dbReference type="eggNOG" id="ENOG503324Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145421_0_0_11"/>
    <dbReference type="OMA" id="CQVQTRM"/>
    <dbReference type="OrthoDB" id="2032313at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307704" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="16060" checksum="3EC13F3227F762DD" modified="2011-06-28" version="1">MSISLVLLPLAVAAVAAAQGVSAGRDGQGRVVCQVQTRMRDETLLAAALHDTAAVVGVDQDAITAEWTGVRARFQRGADGIWTAHFAGEVDEQRAVEVVRAIDVAYGRQVQRAVLERLRQQAPAAGLRLESEQVVEDDSVRLVFAVEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7C1</accession>
    <name>F4F7C1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731850.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10305"/>
    <dbReference type="EnsemblBacteria" id="AEB43179">
        <property type="protein sequence ID" value="AEB43179"/>
        <property type="gene ID" value="VAB18032_10305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10305"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_11"/>
    <dbReference type="OMA" id="GFTNKAM"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="72"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="397" mass="41760" checksum="16E15A8838D92E8B" modified="2011-06-28" version="1">MYLTHLECPGCGREHDADVPQNLCDCGSPLLARYDLATVAGVLQPERFGLRPATLWRYRELLPVADPAHVTTLGEGWTPMLRAPTYGARIGVDELLVKDEGLTPTGSFKARGAAVGVSRARELGIRRIAMPTNGNAGAAWATYAARAGLDAIIAMPVDAPSICRRECVAAGADLRLVDGLIGDAGRQIAALVAASAGTIFDAGTLREPYRLEGKKTMGYEIVEQLGWQVPDVIIYPTGGGVGLIGIHKALGELRELGWIEDRLPRLVAVQSTGCAPIVRAFAAGEDRADPWPDAHTVAFGITVPAPLGDQLILAALRASAGTAIAVDDAEILADLRDFAAREGLLLCPEGAACLTAARKLRAGGWIRAGERVVVLNTGAGVKYPDTVDVSDVPVLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7K4</accession>
    <name>F4F7K4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_16695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16695"/>
    <dbReference type="EnsemblBacteria" id="AEB44443">
        <property type="protein sequence ID" value="AEB44443"/>
        <property type="gene ID" value="VAB18032_16695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16695"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OMA" id="HEFTWDF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022508">
        <property type="entry name" value="ABC_trspt_anch-rpt_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03771">
        <property type="entry name" value="anch_rpt_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="25907" checksum="317A7179EABB2B27" modified="2011-06-28" version="1">MDLGGRPVLRDIRLHLDRGELVGLLGPNGAGKTTLLRAILALTRIRAGRVLVEGKPSRPGRSDIGYVPQRHEFTWDFPISVEQAVMSGRTGRMGLLRRPGVADWRAVGDALDRVQLTELRRRPVGELSGGQRQRVLVARALALAPRILLLDEPFTGLDMPTQELLGQLFTSLASEEHAVLMTTHDLVAAVDTCTRLVLLNGRIIADGHPADLQDAELWTKTFGVSETSPLLKLVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7U5</accession>
    <name>F4F7U5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="15" type="ordered locus">VAB18032_23160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734384.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23160"/>
    <dbReference type="EnsemblBacteria" id="AEB45732">
        <property type="protein sequence ID" value="AEB45732"/>
        <property type="gene ID" value="VAB18032_23160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23160"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_2_11"/>
    <dbReference type="OMA" id="WADHLAF"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026389">
        <property type="entry name" value="SecA_Actinobact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04221">
        <property type="entry name" value="SecA2_Mycobac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="14">
        <location>
            <begin position="1"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="84"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="414"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB45732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="764" mass="83044" checksum="A248EB6252A35DB6" modified="2011-06-28" version="1">MGVSQRLKTRFRRFLQRPGTTVDLAPLEKLLPAIEAREEKVQAFDDAELTEAAAVASTYEEICALGREAARRGLDQRPYDVQLLGAMSLLSGKVAEMATGEGKTLTAAIAAYGHVRLGNGPVHVLTVNDYLARRDAQWMEPVYTLLGLTVGWVNEASTPAERRAAYACDVTYVAVSEAGFDFLRDQLVTDVADRVQPALRTAIVDEADSILIDEARVPMVLAGSVASEQDPVHAAAALVRGLRKGKHYTVAEDGRSVAFTSAGLAAVEAKLGIDLYDEENVEQLSAVNVALHAHALLHRDVDYIVRDGTVELIDEMRGRVAQRRRWPDGLQAAVEAKEGLDATAEGEVLGTIAVQAYIGLYPTVCGMTATAVLVGDQLREFFGLEVAVIPPNTPCVRVDEPDRIYATRAEKDEALVDEIQRCHAAGRPVLVGTLDVKESEQLAAGLNAVGVPCVVLNAKNDDEEAAIIAEAGAYGAVTVSTQMAGRGVDIRLGGSEQIDRERVAELGGLYVIGSGRHDSRRVDDQLRGRAGRQGDPGGSVFFVSLEDDLVARHAGDTVPPSPRMNADGLVTDPQVDYAVEHAQRVAEGVNHEIHRNTWRYSVVIEQQRKALAERRERLLTSDVAALMLLDKMPEKAGEMDEDLLARVARSIALYHLDRLWADHLAELSEVREGVHLRALGRLDPLDEFHRAAVPAFTDLVPEIEARTLATFAETEFDEDWEPDAAELVRPSATWTYLVHDNPFGSELDRLIASVGRRLSGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Y2</accession>
    <name>F4F7Y2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735605.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29431"/>
    <dbReference type="EnsemblBacteria" id="AEB46957">
        <property type="protein sequence ID" value="AEB46957"/>
        <property type="gene ID" value="VAB18032_29431"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29431"/>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017257_1_0_11"/>
    <dbReference type="OMA" id="LHLETQT"/>
    <dbReference type="OrthoDB" id="937807at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="422" mass="46720" checksum="5FDF922164D369E1" modified="2011-06-28" version="1">MPQQQSSPLAFFDNANSQPDFTVGLRGYNTGQVDDFIGRLNAALSQANKDRADAEQALNDAQRRLRQSEQRLTALEQKLTDTSKQLEENSRPTLSGLGTRVEQILRLAEEQANDHRNEAKRESEGILSAARLEAREITDKARAEAAAMKATAEREAGNLRTAAEREAAEVRVQARREADTLRADAERETKQLRTVTAHEVAELKSTVEREVATLRATAEREITQQRAKAAREAEEKRAEATKLLTDARDKRDKDLQALELQLAERREKAEREESERHAAQVAQTQKLVGEAEQRARAAQERAKEIEQRAEARRVESERNATETIEKAKALADRTLNEARAESQRLLSEARTEAELTTQAARREVEDLTRQKDAVTSQLGQMLSGLAGIVPGVPNNAAPAEKPAATAKPADDAEKKVAADTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Z9</accession>
    <name>F4F7Z9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735622.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29516"/>
    <dbReference type="EnsemblBacteria" id="AEB46974">
        <property type="protein sequence ID" value="AEB46974"/>
        <property type="gene ID" value="VAB18032_29516"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29516"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="QEFNVDR"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="30272" checksum="9121AF3A45202299" modified="2011-06-28" version="1">MSDDVAIHVRGLRKAYGDNVAVAGLDLDVHRGEVFALLGPNGAGKSTTVEILEGYRHRDAGEVRVLGVDPTAASPQWRARVGIVLQGTGEFDELTVAEVVRHFAAFYPDADDPDKVIARVGLAGKARARTHTLSGGQKRRLDVALGIIGRPELLFLDEPTTGFDPEARREFWELIRDLAAAGTTIVLTTHYLDEAEALADRVGVITGGRLVEVAPPTSLGNRQEALATVSWRTPEGTLESAQSATPTALVAELAARFGGEVPGLTVTRPTLEDIYLRMIGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8I6</accession>
    <name>F4F8I6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17135"/>
    <dbReference type="EnsemblBacteria" id="AEB44531">
        <property type="protein sequence ID" value="AEB44531"/>
        <property type="gene ID" value="VAB18032_17135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17135"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_1_0_11"/>
    <dbReference type="OMA" id="QWWKNKH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="37323" checksum="05DEDF3AA244D5AB" modified="2011-06-28" version="1">MPSQSTTGSDFAVLSRRITDAGLMRRRPAYYVVRLSIVTLMFVGGWAAFFALGSSWWQMITAVFLAVTFAQVALVAHDLAHRQVFRTRRPSAVAGLLAGNLGIGMSYGWWMDKHTRHHNNPNHDDLDPDVAPEVLVWTTESAIGRRGLKGFITRHQATLFFPLLTLLAVSLKVSSVKALRDGTVKQRRVESALLILHAVGYLGALVLVLSPPQAVAFLLLHQALFGVYLGMTFAPNHKGMPHPTGTEDYLRKQVLTSRNVRGNRLVDAALGGLNYQIEHHLFPGMPTSNLRKAQPIVQAYCAEIGVAYVQTGLVTSYRQALRHLHEVGAPARAEHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8M5</accession>
    <name>F4F8M5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_23350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23350"/>
    <dbReference type="EnsemblBacteria" id="AEB45768">
        <property type="protein sequence ID" value="AEB45768"/>
        <property type="gene ID" value="VAB18032_23350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23350"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399511_0_0_11"/>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="147"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="689" mass="73028" checksum="E408CC99742E1EA9" modified="2011-06-28" version="1">MTALPALAYGKPAATALQMQAEPNQVQNVTVVQGDGYATLAWTHVDGATDYQIERTPVAEDGTATGNGVIVGVWRPNRQINNDKPTFADAGFAPGDRFQWRVRARFGTEAQPYSAAVVGTTKPHWGDPNTPGQNLRTQWEQTLGAQYTSDVNEYAYTAAIDELSDRVRVTEIGRTINNRPINMFIIGYPTAPATPDAVAATNPLAVNCNVHGNEPGDREACFIMARQLAFTNDPATLDLLSKTTVLIVPTINGDGRAANSRGNSTGQDLNRDYSLIRQPETQAFMEMVRDYRPITGYDGHEYGNTNTGDLPMLSPRHANVAEGIFDESQNMIEGHMYTQGAKDGWWACPYGCTPGANVGLGQETILRNTLGLKNVVNSLLELRSSGGPTRPNESNTANNRRRKTYSGLWTFNQFLAYHVANLDRITKARGEAIKLQSANSGQIVLEGSREIKAYPAPHPGEAPPPVDAPREENILRHAPCAYKLTEAQYNGARTDGPAGRQTTVAQRLAAHGWKVIKVADGYVVPLSQPERGLIPLLLDEQAVEGLVAGERIAPTLTGTHNGPLTVSGVACLAGATVRGPITVQAGATLIVNGSSINGPVSATGAAGFVLTDSTVRGPVSATGTRGPVVLVGNDVSGPVNVVNSAAVAPLIAGNTVNGPLSCTGNSLAPGNFEVANTVSGPKASQCSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8P3</accession>
    <name>F4F8P3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_23440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
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        <property type="protein sequence ID" value="AEB45786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23440"/>
    <dbReference type="EnsemblBacteria" id="AEB45786">
        <property type="protein sequence ID" value="AEB45786"/>
        <property type="gene ID" value="VAB18032_23440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23440"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_3_11"/>
    <dbReference type="OMA" id="VIVHAWR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="118" mass="12718" checksum="58417EA93B9CA904" modified="2011-06-28" version="1">MIVDRSDPDMPVIRVGGDLAYTTASPLRSEIDRELQAGPATLVLDFANLQFIDSTGLSIIVHTWREGLRDGVTLRLRAVPRFLETILDMTGVTNLLARSTSGDAPLGTEPDGQPTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8T8</accession>
    <name>F4F8T8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735666.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47018">
        <property type="protein sequence ID" value="AEB47018"/>
        <property type="gene ID" value="VAB18032_29736"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29736"/>
    <dbReference type="HOGENOM" id="CLU_823726_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312804" evidence="1">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="35025" checksum="174C56E2CCF74B5D" modified="2011-06-28" version="1">MPRRPLRRLSQAIALAVAIPVLAAGCATEEPVAPLDGQQAATNLDAEPEPSPTPDAPAPLAGFTPRSISYLNAEITVTGVEVSPQTPRSYGDTTGTPEYGDAHYAYLAVKVANQLNFTTFLVQDGVFLALADDELVPLDSSGSPATDVIAPGATATGWYAFELPAGATLEGASLVFGPAGHRQERLPLIGDLPTPEYPKAITVASPGTVLTGNSGCPLTVEVEKAYLAHWVGFDEGGRSHTTKQAEAGRLKLHLGLAVTGPADRSGCFIATGSGGDVHLIVDGDRLGDYPELGGTTNVAAGATDRQYLVFDIPDSGQVEIEWGRLGGKQVRIPVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8W7</accession>
    <name>F4F8W7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735695.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29881"/>
    <dbReference type="EnsemblBacteria" id="AEB47047">
        <property type="protein sequence ID" value="AEB47047"/>
        <property type="gene ID" value="VAB18032_29881"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29881"/>
    <dbReference type="eggNOG" id="ENOG503264Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085644_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307516" evidence="1">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="26868" checksum="DD4CB60C17622611" modified="2011-06-28" version="1">MRNRTLATVCTALALVPLCLSGCAPAAPAPPAATVTSLPPDPRAVLVAAAELTRQTTSTMTMGRTSLSLLFTATAVVDPAAGDFAVTAEVTADGKVTRWAMTAVNDSAFLRFDDLWDGRWLRMPSADVLTTIGLDIMPNGDPGEIGKLVGQIVEVRREAPGHFSGTLDLTHTSSVALTELPESTAETLRSLPFKAQIDAEGRLIELTLRLSDVDMSLGAVTVAFGDFGATPDITPPAAAEVMDAPKDLTEHLSQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8X1</accession>
    <name>F4F8X1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735699.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29901"/>
    <dbReference type="EnsemblBacteria" id="AEB47051">
        <property type="protein sequence ID" value="AEB47051"/>
        <property type="gene ID" value="VAB18032_29901"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29901"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047251_4_0_11"/>
    <dbReference type="OMA" id="PFRCCAA"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="29776" checksum="5E92E8AA8D0F90F6" modified="2011-06-28" version="1">MARGPVAFVLGGGGVLGAVEVGMLRALFRARIRPDLVLGTSIGAVNGALVAADPSEAVTDRLVRLWASPEASEVYGDSVARQLRRFAARTHLHSPRPLRKLLENELGAETTFADLLVPFRCCAANIERAAEHWFVSGPVVPAVLASASVPGLLPPARIGDQHYVDGGIVNSIPIGEAVAAGATRIFVLQVGRIERALTPPRRPWEIAQVAFEIARRHRFAREMAALPDGVEVHVLPTGGLEPRDDTPWAYRDMAAVGRRISRAYAASRHYLANLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8X9</accession>
    <name>F4F8X9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29941"/>
    <dbReference type="EnsemblBacteria" id="AEB47059">
        <property type="protein sequence ID" value="AEB47059"/>
        <property type="gene ID" value="VAB18032_29941"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29941"/>
    <dbReference type="eggNOG" id="COG3176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058962_0_0_11"/>
    <dbReference type="OMA" id="YLRLGAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="28044" checksum="AA929080A8F1B6DF" modified="2011-06-28" version="1">MGMAALPAAQVTLTTSGYALSLADDHDQVEAAQRLRHQVFAAELGATGITDPTGLDRDAFDPYCDHLLVRQESTGEVVGTYRLLPPGRTVRRYAEGEFDLTALDPLRAHLVEAGRSCVHPDHRNGAVINLMWAGITRYLHLRNLRWLGGCASTPVADGGLAAAEVWAQARARHLAPPPLRVRPLRPWFAEPGVPQEPVAATARLVPPLLRGYLRLGAWICGEPAYDPDFGAADFYVLLSMDRMNPRYLRHFLGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Y6</accession>
    <name>F4F8Y6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ordered locus">VAB18032_29976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735714.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29976"/>
    <dbReference type="EnsemblBacteria" id="AEB47066">
        <property type="protein sequence ID" value="AEB47066"/>
        <property type="gene ID" value="VAB18032_29976"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29976"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_11"/>
    <dbReference type="OMA" id="KIITCHI"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="182"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="256"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="304"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="371" mass="39123" checksum="15966CEB62ABC398" modified="2011-06-28" version="1">MSKVLVLNCGSSSVKYRLYDDDRVLTKGTVERVGEPDGGPPDHAAAVRQILAGLDLSGLTVVGHRVVHGGRRFTAPALVDDAVLAAIADLVPLAPLHNPANLAGIEMARAALPQVPQVAVFDTAFHHTLPESAATYAIDRDTAQRYGVRRYGFHGTSHSYVSRRTAELLNRPYAEVNTISLHLGNGASACAIAGGRSVATSMGMSPLEGLVMGTRSGDLDPTIVFHLRREGGLGVDEIDDLLNHRSGLLGLTGVNDMREVLARRADGDEAATLAFDVYCRRITEYVGAYYALLGRVDAVTFTAGVGEHAAPVRAAALTGLTRLGITVDADRNTGSGDRLISPDGAEVAVCVIGTDEEREIARAARAVVNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9E7</accession>
    <name>F4F9E7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732012.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11115"/>
    <dbReference type="EnsemblBacteria" id="AEB43341">
        <property type="protein sequence ID" value="AEB43341"/>
        <property type="gene ID" value="VAB18032_11115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11115"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037730_0_0_11"/>
    <dbReference type="OMA" id="DIHLNPA"/>
    <dbReference type="OrthoDB" id="764005at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="267"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="534" mass="56382" checksum="DB0A33676BC30745" modified="2011-06-28" version="1">MGDQEHEQPEHGRQAETPARRQRRFSSLRRTGAAPRRPGRLTGVRRVGVALAVLVVTLAGVLLGTLAGGQVGTDIGPFRAKLSLSPAVDGGTTVKIPPLGALLLNSHDGPTQLTVELGALDQSRVEALLDDPASLNRATQSAVDEVHEGVLRLGLRTLGATVLATVLLALLVFRNTRRAAWAGTLALLITAGSLGTAATTIRPQAIEEPTYEGLLVNAPAIVGDVRKIANDYTRYAEQLQRLIGNVTQLYTTVSALPVYEQEPGTTRVLHISDMHLNPTAWQLIRTVVEQFGIDVVIDTGDITDWGSEPEASYVGSISLLRKPYVYIRGNHDSGRTSAAVARQPNAIVLDNATTTVAGLTIAGIGDPRFTPDKSTSPAAGGPIPPTADELTATGEKLAATIRSAPTPVNIALVHDPVIATPLSGTTPLVLAGHIHRRQIDQLPEVPGQQPTTLMVQGSTGGAGLRGLEGEEPTPLTMTVLYFDQEKQLQAYDTITVGGTGQAQVNLERTVINPPPTPLTTPTPTPTTPTPTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9K3</accession>
    <name>F4F9K3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733236.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17395"/>
    <dbReference type="EnsemblBacteria" id="AEB44581">
        <property type="protein sequence ID" value="AEB44581"/>
        <property type="gene ID" value="VAB18032_17395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17395"/>
    <dbReference type="eggNOG" id="ENOG502ZB65">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876924_0_0_11"/>
    <dbReference type="OMA" id="GHLYMED"/>
    <dbReference type="OrthoDB" id="844909at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="35456" checksum="C82E1EAF17276B09" modified="2011-06-28" version="1">MIDVDVRFQEAAAVRRTESVAYSHLSVELGHFYADDFGSGCQDLRRRFARIADWSPAIPALARQGLSAPRQPRISTCFMVDDYFHRFGSPREVIPQVQSAAAELGLVLDYVARESSFARHGGVELAQMVVDTLVVEPPRHTTGSRPPLSESGWLSNGMRSPGYVDAPAMTLPRPWSPPVQSGDPRHSIFVDIELWSDEPQTREWACALLASVWQMARLGVLRHRGQTLMQPSRLTGELPADWDELPAIVQLNPTAAPFCAYRTLTLMDTQYLPVELAVRTILGQVAVPPAVAQQITRRAGGEGLDLPSELVDRLSYVFIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9M1</accession>
    <name>F4F9M1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733254.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17485"/>
    <dbReference type="EnsemblBacteria" id="AEB44599">
        <property type="protein sequence ID" value="AEB44599"/>
        <property type="gene ID" value="VAB18032_17485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17485"/>
    <dbReference type="eggNOG" id="COG3559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036785_2_0_11"/>
    <dbReference type="OMA" id="AQQMRPF"/>
    <dbReference type="OrthoDB" id="1885421at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="552" mass="57231" checksum="2031D278F0C12A8E" modified="2011-06-28" version="1">MATTTLRRPTPPVRFRASAVTGTAILLRFMLRRDRVRFPAWTLGLALLMTYFATALESIASTPQELESLTAFTASPAGALFGGRGLGFDQLTIERFLVGQYGLYVTIGAGLMGLLTVVRHTRAEERSGRAELIRANVLGRHAQLTAALVVTVAMAVLVTLLIGAMMAGRGYDLAGSVLFGASVGATALAFAGIAAVTVQLSEYPRAAAGAAGAALGAAFVLRGLGDMAAVQDSGPSWLSWLSPIGWSQQAAPYVYDRWWPLAISLLFAVGTAAVGYGLSARRDFGAGLLPPRPGAPRAAAWLASPLALAFRLQRAGLIGWSIALIVAGVAYGSFTQPLIDSFADAPGDLLAIMGGSENMLDGYLGMMGVTMALAVGVYAVLAVHTLRAEETDGRAEPVLATAVSRTAWLGSHVAVTAVGVAWLLLLAGVGMGVGAALSTQDPGLIGTLLLGHVAHTPAVWQIMAIAALLYAIAPRALPVIWVALGYGLIASYFAPILDIPDAVLDLSPFAHIGEYPLEDVNMVAVAVLTLLSAALLRAATVALKRRDLAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Q3</accession>
    <name>F4F9Q3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ordered locus">VAB18032_23655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734481.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23655"/>
    <dbReference type="EnsemblBacteria" id="AEB45829">
        <property type="protein sequence ID" value="AEB45829"/>
        <property type="gene ID" value="VAB18032_23655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23655"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_11"/>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="581"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="668"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="711"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="346"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB45829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="776" mass="82669" checksum="10769694883340E7" modified="2011-06-28" version="1">MATLPVLPLTDAVLLPGMVIPVTLDPTTQAAVDAARATGDHKLLAVPRLDGEYGSVGAIATIEKVGRLPSGEPAAVIRGIARARIGSGVPGPGAALWVEASEIDEPAPAGKARELAREYRALVTSVLQQRGAWQVIDAVERMTDLGELADSAGYAPWLSLTQKTELLAAPDVTTRLELLVGWVKEHLAEQEVTEQINSEVREELEKTQREFLLRQQLAAIRKELGEDAPDGSADYRARVETADLPEKVREAALREVGKLERASDASPEAGWIRTWLDTVLEMPWSTRTEDNTDLTAARAVLDADHAGLSDVKDRILEYLAVRNRRAERDLGVIGGRGSGAVLALAGPPGVGKTSLGESVARALGRRFVRVSLGGIRDEAEIRGHRRTYVGALPGRIVRALREAGSMNPVVLLDEVDKLSAGYAGDPAAALLEVLDPAQNHTFRDHYLEVDLDLSDVLFLATANVVEAIPGPLLDRMELVTLDGYTEDEKVAIARDHLLPRQRERAGLTADEVDVDPSALGRIAGEYTREAGVRQLERALAKIMRKVAVALTDDAAPVRVDAENLVRYLGRPKHTPESAERTAVPGVATGLAVTGAGGDVLFIEATSMEGDPGLTLTGQLGDVMKESAHIALSYLRANGRRLGLDPNALAGRRIHLHVPAGAVPKDGPSAGITMVTALASLASGRPVRPEFGMTGEVTLSGRVLPIGGVKQKLLAAHRAGLTEVIIPARNEPDLDDLPTEVREALTVHTLADVADVLALALRPADADTLITPNLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9U1</accession>
    <name>F4F9U1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_23845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23845"/>
    <dbReference type="EnsemblBacteria" id="AEB45867">
        <property type="protein sequence ID" value="AEB45867"/>
        <property type="gene ID" value="VAB18032_23845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23845"/>
    <dbReference type="eggNOG" id="ENOG50332S7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096434_0_0_11"/>
    <dbReference type="OMA" id="FMTLMEF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309182" evidence="3">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="29322" checksum="481F2641D76D2277" modified="2011-06-28" version="1">MVCLVLLAALSGCMQLNIGLTVKADDTVSGQLLLTAERKVLTLNNKTVEQGFADLRQNIPALPPGPETPYATDTHFGFQINYQNMPLDQFDSESLRIVRANDRYVFTLPLDPKKYGGKVAEQNPENQARFMLLMSFEIAVTFPGRVLDVNAGGQVNDRTVTWRVNPNEPKPVELRAVAEAPPRPPAAAADTDAAGGPPWLLITAGAVVLLLVALLVVLLLRRPRTAGVSTTAGDGSGAGEVTTTTDGGGAGDATTTVEPTDGTAIAAAPRTTIPGSPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9W5</accession>
    <name>F4F9W5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23965"/>
    <dbReference type="EnsemblBacteria" id="AEB45891">
        <property type="protein sequence ID" value="AEB45891"/>
        <property type="gene ID" value="VAB18032_23965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23965"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717305_0_0_11"/>
    <dbReference type="OMA" id="LRWESAT"/>
    <dbReference type="OrthoDB" id="650584at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309183" evidence="1">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="34577" checksum="0031CD424E45E5A7" modified="2011-06-28" version="1">MVLGVVAGAALAGLLSVTAAVAAPLAAADRAAPTARTDVYIKDVDGDVGLQPHPLNPLWASPDIKVCPTPVECATSQNPIVGITNYIFVKLRNPGPYGAGTSVGTLHVYRTTPGGGATWPAHWTHIGAATVAAPAGVTTVTIPWTGVPGPGHFCLLARWVSDTDPMVAEGPDISTNTRNNNNIAWRNVDSVRLSAGETNPAVRPFAIGNSLRVPSANDLVFEATQPLQGIGGRVVVDLGPDLFERWRAGGAVGTGVRAVGRTQVEIVEPTRASLGNLRLNPGERVEFSLLFTATTASDREIAFNVTQFGPDASGAKRTDLGGVQYLISAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA09</accession>
    <name>F4FA09_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735766.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00180"/>
    <dbReference type="EnsemblBacteria" id="AEB47120">
        <property type="protein sequence ID" value="AEB47120"/>
        <property type="gene ID" value="VAB18032_00180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00180"/>
    <dbReference type="eggNOG" id="ENOG5031VBG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_1_3_11"/>
    <dbReference type="OMA" id="WRNFLAA"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="77" mass="8299" checksum="21BF7E52497E4B39" modified="2011-06-28" version="1">MNEIRNTSVLAQLADAPWRTSTRSQTSNCVEVAPLRNGPAAVALRDSKDRGGPVLLFNRAGWLGFISGAKNGQFDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAN8</accession>
    <name>F4FAN8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733308.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17755"/>
    <dbReference type="EnsemblBacteria" id="AEB44653">
        <property type="protein sequence ID" value="AEB44653"/>
        <property type="gene ID" value="VAB18032_17755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17755"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108911_0_0_11"/>
    <dbReference type="OMA" id="TVDQTMI"/>
    <dbReference type="OrthoDB" id="1380653at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="154" mass="16549" checksum="87C1910AF550D466" modified="2011-06-28" version="1">MRTFASIDELAGAVGEPLGPGPWFPVDKRRVELFADATDDHQWIHLDQERAAAGPYGGTIAHGYLTLSLIPALVGQLYRVDGVRMGINYGLNRVRFPAPVRVGSAVRVVATIDQVTPFDGGAQLVATVTVHNDGGDKPVCVAETVSRLYTDPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAP7</accession>
    <name>F4FAP7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-hydroxymuconic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17800"/>
    <dbReference type="EnsemblBacteria" id="AEB44662">
        <property type="protein sequence ID" value="AEB44662"/>
        <property type="gene ID" value="VAB18032_17800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17800"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="OMA" id="EELAFGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017628">
        <property type="entry name" value="OHmuconic_semiald_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03216">
        <property type="entry name" value="OH_muco_semi_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="37"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="505" mass="53006" checksum="0BDCAF0BA51222C3" modified="2011-06-28" version="1">MTSGRTTRWPSGLIDGRRSGDLLLPNYVGGEFVTGGTSFAKVSPVTGETLLHVAEADQATVDAAVTAARAALRGPWGAMGEGERAAVLRRVADELERRFDDLVAAEVADTGKSVAQARTLDIPRGAANFRTFADIITATPTESFTTVTASGGRALNYAVRKPVGVVAIIVPWNLPLLLLTWKVAPALACGNAVVVKPSEETPSSATVLAEVMAAAGVPDGVFNLVHGFGPGSAGEALTRHPGVDAITFTGESATGSAIMRAAADGVKAVSFELGGKNAGLVFADADLDAAVEGSVRSSFTNGGQVCLCTERIYVQRPVFEEFAARLAKRAEELAFGWPSEPATMTMPLISAKHREKVLGHYELARAEGATVLAGGGVPVFGDDRDSGSYVQPTVLTGLGRHARTMREEIFGPVCHIAPFDDEDEAFALANDSEYGLAATVWTRDVGRAHRAGARLDAGLVWVNTWFLRDLRTPFGGVKASGVGREGGTHSLHFYSELTNVCVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAT3</accession>
    <name>F4FAT3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17980"/>
    <dbReference type="EnsemblBacteria" id="AEB44698">
        <property type="protein sequence ID" value="AEB44698"/>
        <property type="gene ID" value="VAB18032_17980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17980"/>
    <dbReference type="HOGENOM" id="CLU_2412365_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="92" mass="9906" checksum="F26109684DC1AB84" modified="2011-06-28" version="1">MELRAALAANAGPGDDVGPVEVQRSAEMAIAVIGLVFAGVGTAKTIWDWWNSRRTHGVTVTVLLGDGTRIEVSNLNDGQLEITFQQAETRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB14</accession>
    <name>F4FB14_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24395"/>
    <dbReference type="EnsemblBacteria" id="AEB45977">
        <property type="protein sequence ID" value="AEB45977"/>
        <property type="gene ID" value="VAB18032_24395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24395"/>
    <dbReference type="eggNOG" id="COG1996">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039030_1_0_11"/>
    <dbReference type="OMA" id="WFAPNGL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="37750" checksum="79DB34132DFFF4CC" modified="2011-06-28" version="1">MEHAPGTTALQCPYCGHQQQIAAATREVREHSFDGLATLARKPAAAVGAYVYRCPGCGASTESAALAERCQFCATPLVPQQAADELIAPEAVLPFAVDRNGVRTALSTWCRSRWFAPSSLKKVSEAETLKGTYLPHWTFDARTVSDYRGKRGEHYYVTETYTVTVDGKTETRTRQVRHTRWHSASGTVRRDFDDVLVPATTHLPTNKLDELTPWPLNEAVPYEQDYLAGYHALRYDTEPEAGLVEAKARMAPVIERDCRSDIGGDEQQVDAVDTSYSDVTYKLLLLPVWIAAYLHAGRSYQVLVNARTGEVIGERPYSKAKIAAAVLAALAVIALVVFLMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB35</accession>
    <name>F4FB35_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactate/malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_00480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735825.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00480"/>
    <dbReference type="EnsemblBacteria" id="AEB47180">
        <property type="protein sequence ID" value="AEB47180"/>
        <property type="gene ID" value="VAB18032_00480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00480"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_2_1_11"/>
    <dbReference type="OMA" id="CYIIVLT"/>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="6">
        <location>
            <begin position="154"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="316" mass="33040" checksum="032E55ED411D057E" modified="2011-06-28" version="1">MGKKVTVVGAGFYGSTTAQRLAEYDVFDTVVITDIVEGKPAGLALDLNQSRAIEGFETKVVGVTTGPNGEGYEAIEGSDVVVITAGLPRKPGMSRMDLLETNAKIVRQVSENVAKYAPSAVVIVVSNPLDEMTALAQLATQFPHQRVLGQAGMLDTARFSNFVAEALNVPVKTVKTLTLGSHGDTMVPVPSKSTVDGKPLREAMPAEQIEELVVKTRNGGAEVVALLKTGSAYYAPSAAAARMAKAVAEDSGEVMPVCAWVDGEYGISGVYLGVEAEIGAQGVKRVVETDLDADELAALNEAAEAVRAKQADVASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB88</accession>
    <name>F4FB88_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_00745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735878.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00745"/>
    <dbReference type="EnsemblBacteria" id="AEB47233">
        <property type="protein sequence ID" value="AEB47233"/>
        <property type="gene ID" value="VAB18032_00745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00745"/>
    <dbReference type="eggNOG" id="COG4214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_1_11"/>
    <dbReference type="OMA" id="LAVWMDT"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="43179" checksum="E8CCB2E7C3DEDDC8" modified="2011-06-28" version="1">MSITAVTKEGPAAVAPAPTVGSHVRDYWQRVRGGDIGALPAVAGLLVLCTIFSIMRPSFLTAGNFANLFTQGAAVTLIAMGLVFVLLLGEIDLSAGFASGVCAAVLANLVTVLGYPWYVAVLAALLTGMVIGTTLGFLVAKVGIPSFVVTLAGFLAFQGVVLLLMKEGRNISVREPVVVAIVNRNMPVALGWTLAAIAVAGFAVVQLLRYRSRAARNLINDPFPVVLGRIAALALVLGLAVYVLNLERSLNTLITSLKGVPIVVPIVAVLLVVLTFVLQRTSYGRHIYAVGGNREAARRAGINVDRIRISAFMICSTMAAVGGIVAASRANSVDPNTGGSNVLLYAVGAAVIGGTSLFGGKGRILDAVLGGAVVAVIDNGMGLMGYSSGVKYVVTGVVLLLAASVDALSRRRASATGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBF5</accession>
    <name>F4FBF5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05625"/>
    <dbReference type="EnsemblBacteria" id="AEB42251">
        <property type="protein sequence ID" value="AEB42251"/>
        <property type="gene ID" value="VAB18032_05625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05625"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712497_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="16199" checksum="77BDED55CDF1FDDA" modified="2011-06-28" version="1">MMSTEAVHYDVHDAKIHLSRIIERVERGEEIIIDRAGTPVAKVVPLGRGANRTAIGSLAGQLDIPSDWDSPQTTSQVLAGVRNGGTIEITDRGHPIARLVPVSDDRSMLAELVEAGRVVAPTGGGPVPLPPKLGDENVDVAASLAAMRNEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBP2</accession>
    <name>F4FBP2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YlxR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11950"/>
    <dbReference type="EnsemblBacteria" id="AEB43504">
        <property type="protein sequence ID" value="AEB43504"/>
        <property type="gene ID" value="VAB18032_11950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11950"/>
    <dbReference type="eggNOG" id="COG2740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147970_0_0_11"/>
    <dbReference type="OMA" id="TCVGCRE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="102" mass="11212" checksum="49095E8D476A431B" modified="2011-06-28" version="1">MVRRTPPERTCVGCRQRAPASELLRIVAIDDEAGYGLRPDPARRLPGRGANMHPDPACFAQAVRRRAFGRALRLAGVPDDGALAEYLTRQPPRPAIRSGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBQ2</accession>
    <name>F4FBQ2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_12000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732183.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12000"/>
    <dbReference type="EnsemblBacteria" id="AEB43514">
        <property type="protein sequence ID" value="AEB43514"/>
        <property type="gene ID" value="VAB18032_12000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12000"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_0_11"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="183"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB43514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="309" mass="33312" checksum="A0C3AC064F91CE43" modified="2011-06-28" version="1">MQRWRGYDAAPGGWGRAVVTIGVFDGVHKGHQATIGYAVARARELGVQSVVVTFDPHPAEVVRPGSHPAVLTEPARKAELIEALGVDVLCVVPFTPEFSRLPAEAFVHDVLVEHLHAALVVVGDNFRFGHRAAGDVALLEQLGRTFGFAVESAPLVAEAGTVFSSTYIRSCVDAGDVTAAASALGRPHRLEGVVVRGDQRGRELGFPTANLLCHRYAAIPADGIYAARLIRRGRREPLGAAVSIGTNPTFSGRERRVEAYALDFTGDLYGERLALDFVAHLRGQIRFDGIEPLVAQIAQDVERTRRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBW8</accession>
    <name>F4FBW8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Substrate-binding component of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733423.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18330"/>
    <dbReference type="EnsemblBacteria" id="AEB44768">
        <property type="protein sequence ID" value="AEB44768"/>
        <property type="gene ID" value="VAB18032_18330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18330"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_9_11"/>
    <dbReference type="OMA" id="TEPCAYR"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313772" evidence="1">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="94"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="42212" checksum="81AA19D0290FAA36" modified="2011-06-28" version="1">MKRCLAAVAAVTLLTLAGCATDTPVATGSSTESAPAGAGTGEQSKFFDQADYDNELALLDATATGPADKPWEQALNPTLVDTTKFKKAGPYKICFSNAALNNPWRQVGYKTMQAEVAAQGDRIKEFVHVEAEGKDQKQIADINDLLGKDCDALIVSPNTTATLTPAVEAACQTGLPVIVFDRGVDTDCPVTFINPIGGYGFGHVGAEFVSQRMKPGGKLLALRILPGVDVLETRWSAAKVAFDKAGVDVVGVEFTDGDPAKTKKIVDDYLQRYGTIDGVWMDAGAVAVAAVEAFQDAGKPVPPINGEDQLDFLKVWKEAGLTAIAPTYPTYQWRTPIIAALRILDGQQVSSPWKLPQPTITQDNLDSYLDADMPPLHYAMCGCTDLPGYPQRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC47</accession>
    <name>F4FC47_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734697.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24735"/>
    <dbReference type="EnsemblBacteria" id="AEB46045">
        <property type="protein sequence ID" value="AEB46045"/>
        <property type="gene ID" value="VAB18032_24735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24735"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908550_0_0_11"/>
    <dbReference type="OMA" id="REYGCRR"/>
    <dbReference type="OrthoDB" id="1210813at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="30798" checksum="41D2A0D4A772834E" modified="2011-06-28" version="1">MYVTGPPTAGPGGPDERFPLPLAGVVTRSYPQGRPFRAPGVRILTDLGVAHGLTVDVADYQRRTRSTYTEMVADLAGELASADRPIGLVVLAHGTPDAETQWPSCWLAAALPGEPLSFAVADHGIVTPFLALRVAAAYVGSHDLSRAAVVVLEQTALLRDPAAGEAPEPTENRATALIFDRAGDLGELRVQLRTGVCTESATGLVRARLANGDPGEALVVGGALARGVPVSAAGAGRAVAAPAGLPCTGPWTAFAAGVAGWRRAAVDRVRLVDHEPRLDTVGECVVDLARPQQVRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC92</accession>
    <name>F4FC92_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC</name>
        <name evidence="12" type="ordered locus">VAB18032_00935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735915.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00935"/>
    <dbReference type="EnsemblBacteria" id="AEB47271">
        <property type="protein sequence ID" value="AEB47271"/>
        <property type="gene ID" value="VAB18032_00935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00935"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_1_11"/>
    <dbReference type="OMA" id="TWELFRD"/>
    <dbReference type="OrthoDB" id="505395at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025747">
        <property type="entry name" value="ThiC-associated_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13667">
        <property type="entry name" value="ThiC-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ThiC-associated" evidence="11">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="530" mass="57801" checksum="E2874ECC2B13BEAD" modified="2011-06-28" version="1">MQVRRKVYVEGSRPEIRVPFAEVGLTGDNPPVRLYDTSGPGSDPQVGLPALRGPWIAERGDVAPVRGPGTPLAGADGKRPTQLAYARAGVVTPEMEFVAIREGMSPEFVRDEIAAGRAVLPLNVNHPECEPAIIGKAFLVKVNANIGTSAVSSSVAEEVEKLTWATRWGADTVMDLSTGKRIHETREAIVRNSPVPIGTVPIYQALEKVGGDPVKLSWEVFRDTVIEQAEQGVDYMTVHAGVLLPYVPLAVNRVTGIVSRGGSIMAAWCLAHHEENFLYTHFRELCEILARYDVTFSLGDGLRPGSIADANDEAQFAELRTLGELTKIAWEYDVQVMIEGPGHVPMHKIKENVDLQQEWCHEAPFYTLGPLTTDIAPAYDHITSAIGAAMIGMFGTAMLCYVTPKEHLGLPDRDDVKAGVIAYKIAAHAADLAKGHPGAQAWDDALSKARFEFRWEDQFNLSLDPETARSYHDATLPAEPAKTAHFCSMCGPKFCSMKITQDLKEYAARGMKDKSDEFLAAGGRVYLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCI1</accession>
    <name>F4FCI1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubid family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730981.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05910"/>
    <dbReference type="EnsemblBacteria" id="AEB42308">
        <property type="protein sequence ID" value="AEB42308"/>
        <property type="gene ID" value="VAB18032_05910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05910"/>
    <dbReference type="eggNOG" id="COG0043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_4_1_11"/>
    <dbReference type="OMA" id="SYQQFWG"/>
    <dbReference type="OrthoDB" id="1012819at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022390">
        <property type="entry name" value="HBDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03701">
        <property type="entry name" value="mena_SCO4490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="486" mass="54014" checksum="867F0996CBBAAC28" modified="2011-06-28" version="1">MAARGFPYTDLKDFLAALERAGELRRVGVPVDPTLEISEVVTRTVRADGPALLFERPTRGEMPVAINLFGTEKRTAMALGVESLDEIGNRIGELLKPELPVGFSGMMGGLGKVMQLKSMPPKKVKTAPCQQVIYRGDDVDLNRLPGLQVWPGDGGIFHNFGLTHTKHPETGKRNLGLYRLQQHSHNTLGMHWQIHKNSTAHHAVAERLGQRLPVAIAIGCDPVVSYASSAPLPADIDEYLFAGFLRGERVEMVDCLTVPLQVPAHAQVVLEGYLEPGERLPEGPFGDHTGFYTPVEPFPVLHVEAMTMQRDPVYHTIVTSKPPQEDHGLGKATERIFAPLLRFLIPDIVDYDLPAAGVFHNCAIVSIRKRYPKHAQKVMNAIWGAHMMSLTKLIVIVDEDCDVHDYNEVAFRAFGNVDYARDLLLTEGPVDHLDHSSYQQFWGGKAGIDATRKLPSEGYTRGWPEEMTMTPEVISLVDKRWKEYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCL9</accession>
    <name>F4FCL9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="4" type="ordered locus">VAB18032_06110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731019.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06110"/>
    <dbReference type="EnsemblBacteria" id="AEB42346">
        <property type="protein sequence ID" value="AEB42346"/>
        <property type="gene ID" value="VAB18032_06110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06110"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_11"/>
    <dbReference type="OMA" id="AGWVRKS"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="225" mass="25072" checksum="842BFB427D5C48BE" modified="2011-06-28" version="1">MGIEEKLPAGVLLTSVEKLVNWSRKSSVWGATFGLACCAIEMMAAGGPHYDMGRWGMEVFRASPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPRWVLSMGVCASSGGMFNNYAIVQGVDHVVPVDMYLPGCPPRPEMLIDAILKLREKIGHEPLGANGRKMLAAREARGDVPVVPYGSMPSSYRSDKARRAEWTKAVREGREEQLRIENWMKAQNHLQPYRGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCP4</accession>
    <name>F4FCP4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage shock protein A, PspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732207.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12120"/>
    <dbReference type="EnsemblBacteria" id="AEB43538">
        <property type="protein sequence ID" value="AEB43538"/>
        <property type="gene ID" value="VAB18032_12120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12120"/>
    <dbReference type="eggNOG" id="COG1842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048860_0_0_11"/>
    <dbReference type="OMA" id="QNAMVLQ"/>
    <dbReference type="OrthoDB" id="1674247at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="30809" checksum="BE8DC9595224C5AE" modified="2011-06-28" version="1">MANPFVKGWKYLMALFGARIDEHADPKVQLQQAIDEAHRQHQALVQQAAAVIGNQRQLEMKLSRQMSDVERLQSNARQALVLADQARAKGDEVEAGRYEQSAQTLATQLVSAEQAAEDLKTLHDQALAAAGQARRAVENNSMILQQKLAERAKLLSQLEQAKMQESVAASLESMSALTAPGTTPSLDEVRDRIERRYANAMGRAELASNSAEGRMLEIQKATLDTAGTARLDQIRASMAGEQLGAGTGQGAVGAPQPATADPAVARLDEIRATMNRDRGTGDTSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCR0</accession>
    <name>F4FCR0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_12200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732223.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12200"/>
    <dbReference type="EnsemblBacteria" id="AEB43554">
        <property type="protein sequence ID" value="AEB43554"/>
        <property type="gene ID" value="VAB18032_12200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12200"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="OMA" id="FMIMTYL"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="283"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="450" mass="48128" checksum="F06D538D3DFAE219" modified="2011-06-28" version="1">MLILVGLLLIIVLTVATGYFVAQEFGYVAVDRGKLKQRAAEGDQASARALEVTARLSFMLSGAQLGITVTALLVGYVAEPYLGAGLAELLGVAGVSSGVTLPLSVVLALVIATVVQMVVGELAPKNLAIARPEPVARALSRSTLFYMAIAGPLIKLFDRAAVRLLRRVGIEPIEELPSGATPEDLEQIIAESRLEGHLDAEMSELLDRGLDFRELTAGEVMVPRVDVHTVRADETISRVVELLDTGRSRFPVRGAEGVDDLVGVVGISDVLRVPPAQRATTPISEVAVPPLLVPETLPLPTVLDRLRSGHRQLACVVDEYGGFAGVITLEDIAEELVGPIRDEDDPPERAPARQDDGSWVVPARWRIDEVADSTGISLPEHPEYDTLSGLVMRELGRVPEVGDRLEIDLPADGDNAEVSPRALVEVLAVDRHVADSVRLQLAGGREEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCU6</accession>
    <name>F4FCU6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="10" type="ordered locus">VAB18032_12380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732259.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12380"/>
    <dbReference type="EnsemblBacteria" id="AEB43590">
        <property type="protein sequence ID" value="AEB43590"/>
        <property type="gene ID" value="VAB18032_12380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12380"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_7_0_11"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="OrthoDB" id="1592033at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="253"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="259"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="284"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="396"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="480" mass="52744" checksum="7B6410EB6241290F" modified="2011-06-28" version="1">MRDQETHVSNDEFETTPGEYELSERQALRRVPGLSTELTDVTEVEYRQLRLERVVLVGVWTEGTQADADNSLTELAALAETAGSQVLEGLIQRRTRPDPATYIGRGKVDDLSAVVLAAGADTVICDGELSPSQLRNLEQRTKVKVVDRTALILDIFAQHAKSKEGRAQVELAQLEYLLPRLRGWGETLSRQTGGSGRGGGAGGGVGVRGPGETKLETDRRRIRHRIARLRREIKAMSTVRETKRSRRTRNAVPAVAIAGYTNAGKSSLLNRLTGAGVLVEDALFATLDPTTRRATTSEGRVYTLSDTVGFVRHLPHQIVEAFRSTLEEIAEADLVVHVVDGTHPDPQEQVRAVREVLTEVGADRLPELLVVNKTDAADEETLLQLKRIWPEAVFVSAYSGRGIDDLRATIEQRLPRPAVDVRVVLPYDRGDLVARLHRQGEVLSTAHLPEGTMLHVRVNEALAAELAPYRDTAEAVSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD08</accession>
    <name>F4FD08_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733495.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18690"/>
    <dbReference type="EnsemblBacteria" id="AEB44840">
        <property type="protein sequence ID" value="AEB44840"/>
        <property type="gene ID" value="VAB18032_18690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18690"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081568_0_0_11"/>
    <dbReference type="OMA" id="TVGYWPP"/>
    <dbReference type="OrthoDB" id="1983084at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="29364" checksum="E46944727D60E96D" modified="2011-06-28" version="1">MIVRTVLTVAALTLQEAARRRVLRSLAALTIVLLALSAWGFSRIDAEFGGLTSGEARLVAAMVLNLVMFGLSLIAALGTAFLAGPTLAGDMESGAALAILARPVHRFAVLVGKWLGLIAFGAGFVALAGLAQLLVVRVTVGYWPPQPVTGLTLLAAQTVVLLTLGLLLSSVSSPMASGVVAVGLFGATWIAGVVGAFGTALDNDSVARVGTVSRMLLPTDGLWRGAMNAFQDPTVLRQFGPAMQGHPFLSDASLTVTYLAWAALWVVLVLGLTGMVFRRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDD3</accession>
    <name>F4FDD3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47344">
        <property type="protein sequence ID" value="AEB47344"/>
        <property type="gene ID" value="VAB18032_01300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01300"/>
    <dbReference type="HOGENOM" id="CLU_217868_1_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="31" mass="3387" checksum="BF1AF6776396F542" modified="2011-06-28" version="1">MFAFFSNRLGCLGSLLVSAIGTIVLLLIFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE53</accession>
    <name>F4FE53_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_19100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733577.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19100"/>
    <dbReference type="EnsemblBacteria" id="AEB44922">
        <property type="protein sequence ID" value="AEB44922"/>
        <property type="gene ID" value="VAB18032_19100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19100"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="QRMQIIF"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="34052" checksum="CF4116373E11127C" modified="2011-06-28" version="1">MSSLLRISDVQVEYRSRGNGRVRAVAGVSLDVAPGQIVGLVGESGCGKSSLARVAVGLTPPSAGEVSFAGRPITPLGWRRRPETEIGLQMVFQNPYASLNPRRTIGAQLLDGVPATVTGAARTDRVIELLDRVGMPAEAADRYPHQFSGGQRQRLAIARALAPQPRMIIADEPVTALDASSQAQVVNLLVGLVRELDMGMLFISHDLALVHEIADVTAVMYLGRIVETAPTRDLWRDPRHPYTRALIDAVPQIGPTPRLPATLAGEVPDPANAPTGCRFRPRCAHAFAPCGDQPPTLDLGGRSAACWLNDPATAPAAVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE80</accession>
    <name>F4FE80_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734798.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25240"/>
    <dbReference type="EnsemblBacteria" id="AEB46146">
        <property type="protein sequence ID" value="AEB46146"/>
        <property type="gene ID" value="VAB18032_25240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25240"/>
    <dbReference type="eggNOG" id="COG4758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075817_1_1_11"/>
    <dbReference type="OMA" id="HLDPHWH"/>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="1">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="21355" checksum="30FABFF1056356E4" modified="2011-06-28" version="1">MEWERHNDDDRLRVSDREREEVVELLGKATTEGRLTLDEYTERVGAAHAAQTRGELARLTTDLPGAPGRSPARSGGQLAPAAEKLLAVFGSDVRKGAWPVPEHIEARAVFGDCRIELHEAQLPRQVTTVDANVIFGSITIVVPEGTEVRLTGSAVFGDKKSKMSGPVTPGGPVVEVRCRVVFGDVTVRPPRKRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEI3</accession>
    <name>F4FEI3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736060.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47425">
        <property type="protein sequence ID" value="AEB47425"/>
        <property type="gene ID" value="VAB18032_01705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01705"/>
    <dbReference type="eggNOG" id="COG2840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2467710_0_0_11"/>
    <dbReference type="OMA" id="DIFNKGH"/>
    <dbReference type="OrthoDB" id="1888882at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="84" mass="9886" checksum="03BF6EF354D281F8" modified="2011-06-28" version="1">MKLKLDLHDIFNKGHDIDRALRGIMDEAVAKKATLVEIIPGKGSGQLKKRVLRFLDQKDVKQLYHRVEKDSKNFGRLFVHFRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEM8</accession>
    <name>F4FEM8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-inositol-3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.250</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="7">GlcNAc-Ins-P N-acetylglucosaminyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mshA</name>
        <name evidence="10" type="ordered locus">VAB18032_01930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:26188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:58892"/>
            <dbReference type="EC" id="2.4.1.250"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase group 1 family. MshA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01930"/>
    <dbReference type="EnsemblBacteria" id="AEB47470">
        <property type="protein sequence ID" value="AEB47470"/>
        <property type="gene ID" value="VAB18032_01930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01930"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_11"/>
    <dbReference type="OMA" id="HTMAKVK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01695">
        <property type="entry name" value="MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017814">
        <property type="entry name" value="Mycothiol_biosynthesis_MshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mycothiol_MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="9">
        <location>
            <begin position="14"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="211"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="1D-inositol 3-phosphate binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
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        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
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        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="421" mass="44547" checksum="FC198F1A14B5009D" modified="2011-06-28" version="1">MHTSPLHQPGTGDAGGMNVYILEVARRLAEADVEVEIFTRATSGDLPPVVEVAPGVHVRHVMAGPLEGLTKEELPGQLCAFTAGVLRAEAARPPGHYDLIHSHYWLSGQVGWLAKDRWGVPLVHTAHTLAKVKNAQLAAGDRPEPKARVIGEEQVVAEADRLVANTRVEAQDLIDRYAADPARVAVVEPGVDLDRFRPPVGDRDAATSAARARLGLPTTGYLVAFVGRIQPLKAPDVLIRAIAALCERDPALAEEVSVVICGGPSGSGLDRPTALIELAASLGVADRIHFLPPRTGAELPLLYQAADLVAVPSYNESFGLVALEAQACGTPVVAAAVGGLVTAVRDQVSGMLVRGHDPVDWANTLARLLPDRSRRAELSLGAARHARNFSWHRTAEGLLAVYGEAITAHRAHLTSALAASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEM9</accession>
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        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">VAB18032_01935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47471.1"/>
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    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01935"/>
    <dbReference type="EnsemblBacteria" id="AEB47471">
        <property type="protein sequence ID" value="AEB47471"/>
        <property type="gene ID" value="VAB18032_01935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01935"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="66" mass="6631" checksum="752C0688CCDA8BE7" modified="2011-06-28" version="1">MSRVAVVTGTSSGLGAGTVADCIAWCATRPPHVNVDRLVVRPLVQAAHIVHRVSGTGAGDRSPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEN8</accession>
    <name>F4FEN8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB42432">
        <property type="protein sequence ID" value="AEB42432"/>
        <property type="gene ID" value="VAB18032_06540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06540"/>
    <dbReference type="eggNOG" id="COG4226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="DHYTYRV"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="114" mass="13016" checksum="8A2F5EDBA7A86814" modified="2011-06-28" version="1">MQPDPHPEITHYTYRVTWSAEDREFVATCAEFPSLSWLAPSQVEALQGLEELLREVVQDMQEQGEQVPLPFAERSYSGKFNLRVGESLHRELAIQAAEDGLSLNQYVLRKLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFM1</accession>
    <name>F4FFM1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736132.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02070"/>
    <dbReference type="EnsemblBacteria" id="AEB47498">
        <property type="protein sequence ID" value="AEB47498"/>
        <property type="gene ID" value="VAB18032_02070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02070"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_3_11"/>
    <dbReference type="OMA" id="MKHFAIF"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="142" mass="15712" checksum="BBFE7EACEB0DF0D6" modified="2011-06-28" version="1">MSESSLAELLRSRGLRLTAQRQLILQAVLDLGHATPEQVHTAVREVAAGVNITTIYRTLELLERLGLVTHTHLSHGSPTYHAAGEHQHVHLVCRECGAIDEMDPELMRPLAEQLARERGFRMDIGHVSFFGNCVRCGDGSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFN3</accession>
    <name>F4FFN3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736144.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02130"/>
    <dbReference type="EnsemblBacteria" id="AEB47510">
        <property type="protein sequence ID" value="AEB47510"/>
        <property type="gene ID" value="VAB18032_02130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02130"/>
    <dbReference type="eggNOG" id="ENOG5032Y6I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154652_1_0_11"/>
    <dbReference type="OMA" id="MCTAPKQ"/>
    <dbReference type="OrthoDB" id="1774182at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010814">
        <property type="entry name" value="DUF1416"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07210">
        <property type="entry name" value="DUF1416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="107" mass="10879" checksum="C83AB5508FEE630D" modified="2011-06-28" version="1">MTAPTAAGCAAPDQAAPLPASIDLEKETVITGVVHSAQGEAVPGAYVRLLDSTGEFTAEVVTSPVGQFRFFAAPGNWTLRALSRHGNGDIAVTAGRGITEVTVTVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFP5</accession>
    <name>F4FFP5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase c2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_02190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02190"/>
    <dbReference type="EnsemblBacteria" id="AEB47522">
        <property type="protein sequence ID" value="AEB47522"/>
        <property type="gene ID" value="VAB18032_02190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02190"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012117_2_0_11"/>
    <dbReference type="OMA" id="VVTNHAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="78"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="760" mass="80089" checksum="77E1E1186D70AE12" modified="2011-06-28" version="1">MSRTLTDYAHAAPSGSYRTQGRYPLREPQHGPIGTARVGPGGYRATVTPPRTATGSASTRSRARRSGDRPGGAELLAAAVGAVPGGSARPGQQQMATAIEECVASGEHLLVQAGTGTGKSLAYLAPALTVDGPVVISTATLALQSQLVEHDLPRLADAVEPLLGRRPTYAVLKGRHHYLCLARLDNSTEDEPADTLFDAPAERPGGGARWLGEAGRLGKQIQRLRDWALETDTGDRDELDPGVDDQAWRLASMPARECVGAARCPYGAECFAEASRARAREADIVVTNHSLLAVDMLAGRHIVPPHRLLVVDEAHELADRVSSAAQAELTPDLIDRSARRARPLLRPETAEMLTEAGDALAIGLAEAPAGRITSGLPGPLREACTLLDAATRAALDAIGDIKADDPDPVRKQQAKAVLDEMSTTAQRLLEEAEHDVAWVERNDNTGRRALVVAPLSVAGTLATHLYDERTVVATSATLALGGRFDTVARALGLEAPPPGPPSPAAEALAASTVRPGGTAPTAGGSAKDSPNQYADSGPGWRSLDVGSPFDYPRQGILYVAAHLPRPSVSGLPDAAGEELLELVTALGGRTLGLFSSRRAATQAAELLRARTDLPVLLQGEEALPLLVRRFREERSSCLFGVMSLWQGVDVPGDSCQLVVIDRLPFPRPDEPLAAARAAAVDAQGGSGFAAVSVPIAAVRLAQGVGRLIRASGDRGVVAVLDSRLETARGYGPFLRRSLPPFWYTTRREVVRGALTRLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG52</accession>
    <name>F4FG52_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 12" type="primary">ureC</name>
        <name evidence="12" type="ordered locus">VAB18032_13420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732463.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13420"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="EnsemblBacteria" id="AEB43796">
        <property type="protein sequence ID" value="AEB43796"/>
        <property type="gene ID" value="VAB18032_13420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13420"/>
    <dbReference type="eggNOG" id="COG0804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_11"/>
    <dbReference type="OMA" id="CHHLSHD"/>
    <dbReference type="OrthoDB" id="157757at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="11">
        <location>
            <begin position="134"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="572" mass="61078" checksum="FC1CF01104531838" modified="2011-06-28" version="1">MSQISRQEYAGMYGPTTGDQIRLADTDLYIEIEKDLRVLGDEVMYGGGKTLRDGMGSSSQATSAEGVLDLVITNVTVLDALLGVIKADVGIKDGRIAGIGKAGNPNIMDGVTPALVTGPGTDAISGEHLILTAGGIDAHVHLVTPFQVQTALSNGVTTLWGGGTGPTDSTNGVTITPGPWNIHNMMRAFETLPINIGLLGKGNSSGRAPLVEQIMAGVPSFKIHEDWGAPPAVIRSCLAVADEYDVQVSIHTDTLNESGYIEDSIAAFEGRTIHTFHTEGAGGGHAPDIIKVAGQMNVLPGSTTPTVPYGINSQSELYDMIMVCHNFNPKVPSDVAFVESRIRTETIAAEDVLLDEGVISMMQSDSQAMGRVGETWLRTIQLAGQMKNVRGKLAEDSSSNDNFRVLRYVAKMTINPAITQGVSHVIGSVTPGKLADLVLWEPAFFGVKPKMVLKGGMIAWSIMGDPNASLPTPQPVYYRPSFGATGTQVAKNCVTFVSKAAHENGIGEQLGLQRQVMPVYQCRNLTKRDMVRNDRTPKLEVDPETFAVKMDGVHATVPAAKNLPMSQLYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG83</accession>
    <name>F4FG83_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_13575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732494.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13575"/>
    <dbReference type="EnsemblBacteria" id="AEB43827">
        <property type="protein sequence ID" value="AEB43827"/>
        <property type="gene ID" value="VAB18032_13575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13575"/>
    <dbReference type="eggNOG" id="COG1230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_11"/>
    <dbReference type="OMA" id="GHEKMLH"/>
    <dbReference type="OrthoDB" id="948593at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="32188" checksum="9EC3AAFC493B6306" modified="2011-06-28" version="1">MGAGHDHGRQVLRAGEKHRGRLWAAFALLAVFMVVEAVGAWVTGSLALLSDAGHMFTDVLGIGMALAAITAASKASRDGQRTFGLYRMEVLAALANAVLLFGVAVYVVVEAVRRFDEPPEVLVGPMLIVAVAGLVANVVAFLLLRSGSKESLNVRGAYLEVLGDLLASVGVIVAAVVIAVTDWWYADPIVAVAVGAFILPRTYKLGRAALRVLVQAAPPHVDITEVRAGLRALDGVADVHDLHVWTLTSGMEVASAHLKLTAGADLGRVLSTARQVLHDRFAIEHATLQVEPQDAEDVCHGAHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGK5</accession>
    <name>F4FGK5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hva1_TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734991.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26210"/>
    <dbReference type="EnsemblBacteria" id="AEB46340">
        <property type="protein sequence ID" value="AEB46340"/>
        <property type="gene ID" value="VAB18032_26210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26210"/>
    <dbReference type="eggNOG" id="ENOG5033N6N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180079_1_1_11"/>
    <dbReference type="OMA" id="PQYQVRS"/>
    <dbReference type="OrthoDB" id="2028293at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hva1_TUDOR" evidence="2">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="72" mass="8206" checksum="3E1DE4C3177144FF" modified="2011-06-28" version="1">MADTEFHTGDHVSWASHSGRAYGVVKEKLTERTHVRGHPVNASPEDPQYRITNDDSGRDVAHRPEVLRRERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGN9</accession>
    <name>F4FGN9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family plasmid maintenance system antidote protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26380"/>
    <dbReference type="EnsemblBacteria" id="AEB46374">
        <property type="protein sequence ID" value="AEB46374"/>
        <property type="gene ID" value="VAB18032_26380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26380"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_2_11"/>
    <dbReference type="OMA" id="YEVGVIP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="29439" checksum="BF8DB881CABE7FEF" modified="2011-06-28" version="1">MEVVGISPSEYLLRELRRRRGAAGLTQAQLGERVFCSDSQVSAIETGTKPPTLPYLTAVDGALETGGYFATLWDELVKGDSSPVWLREWIQIEREATALRWYEHSFVPGLLQTEAYARATFRAARTPAAELDRRVAARLQRQAVLARDPSPQLFVVLDEMVLRRACGGPEVMAEQVAHLISCAEQPHIQLQVVPLSAGIYSGLAGAFILADLPDGARAACVDHQLESQTTGQPDPIARVGLEWDAVRGEALPLGQTLHMLKEAAKTWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGP1</accession>
    <name>F4FGP1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin reductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_26390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735027.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26390"/>
    <dbReference type="EnsemblBacteria" id="AEB46376">
        <property type="protein sequence ID" value="AEB46376"/>
        <property type="gene ID" value="VAB18032_26390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26390"/>
    <dbReference type="eggNOG" id="ENOG503235Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151362_3_0_11"/>
    <dbReference type="OrthoDB" id="2020318at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="85" mass="9857" checksum="C91A9F9E4F681FD1" modified="2011-06-28" version="1">MRRAHLRDHVPYRPTWRCQACGSFWPCSPAKLRLLAEYRGNMPGLLVHLVTLREQATEQLADLHPDAYPNLHQRFTDWVPVTPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGS0</accession>
    <name>F4FGS0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736213.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02480"/>
    <dbReference type="EnsemblBacteria" id="AEB47580">
        <property type="protein sequence ID" value="AEB47580"/>
        <property type="gene ID" value="VAB18032_02480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02480"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_1_0_11"/>
    <dbReference type="OMA" id="GVQAFYF"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="155"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="319" mass="32491" checksum="F756DAB27E4C8F8A" modified="2011-06-28" version="1">MRQSPVAGAGLALALLSAVTFATSGTFARSLINAGWSAESVVIARVGLAALVLATPALLVMRGRWPVLRRNLASIGVFGVLGVSVAQVCFFNAVRYLPVGVALLLEYLGIILVVGWTWLVQGQRPRRLTVAGSVAALAGLVFVLDLTGAGRLDPIGVLWGLGAAVGLAGYFVLAGRVDSALPSVVMASGGMAVGAAVLLALGLVGALPLRASFGTVQFGGQEMSWVVPIAGLVLVAAVVAYLAGIAATRVLGARMASFVGLTEVMFAVLIAWLVLGELPTVVQLFGGALIVAGVALVRIDELRAPALPEQPKAAEPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGW5</accession>
    <name>F4FGW5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_02705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02705"/>
    <dbReference type="EnsemblBacteria" id="AEB47625">
        <property type="protein sequence ID" value="AEB47625"/>
        <property type="gene ID" value="VAB18032_02705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02705"/>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_0_0_11"/>
    <dbReference type="OMA" id="DMIMLKD"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="46"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="140"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="31844" checksum="8D3CB91A23456BA8" modified="2011-06-28" version="1">MNDNGAAGVGMSAATQTLLRAAGLAPEQVRRIIETALVEDLGPDLLDVTSVATIPATQTDTVDVVARADGVVAGLAVAAAVFELADELTGGGRTVEVSVVARDGDRVARGDVLATVTGPTRVLLTAERTALNLLSRMSGVATHTRAWADALAGSKAMVLDTRKTTPGLRMLEKYAVRAGGGTNKRMGLYDVAMIKDNHKYAAGGITAAYRRVRDTFPDVPVQVEVDTLAEAVEAVEAGAKFLLLDNMSPQLLTEVVAAVGDRAELEATGGLTLADAAEVGATGVDFLSVGALTHSSPILDIALDLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH53</accession>
    <name>F4FH53_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_13595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13595"/>
    <dbReference type="EnsemblBacteria" id="AEB43831">
        <property type="protein sequence ID" value="AEB43831"/>
        <property type="gene ID" value="VAB18032_13595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13595"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009723_1_0_11"/>
    <dbReference type="OMA" id="WRAVLWI"/>
    <dbReference type="OrthoDB" id="332732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="236"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="781" mass="82690" checksum="5C20B830A56D57B2" modified="2011-06-28" version="1">MLSRTHRPSPALLVSLAVSTVLLVGLGLLVRQHPVAAWERDVFTLLNRLPAGVTPVLIVVMQLGSYLTVFGTAALAAVLRRFAVARDLLLAGNLAYWLAVVNKVAVARQRPGALLADAVLHDRVTGSLGYPSGHVAVATALALVAARAGGTRWRRLLWPAVAVVAVARVHVGAHLPVDAIGGLLVGWLAVCLTRLVVGEVGPQRSTGVLREALRHRGFDVVRLAPLSGDARGSWPWLVVTGDGRRLFVKVTGGQQRDADWAYKLYRRLRYRHVADEPPYLSAKQQSEHETCLTLLAERAGVRVPSVVTTATLPGGEAVLVQEFIDAAPLDATYGPLPTASIADVCRQVALLHRGGIAHRDLRAANILVDRDGAYLVDFGFGVDDAAADQRARDIVELLVALAGRVDPGTAVDVAIAELGVDDIAGSLPYLQPAVLSRASRDLLRHTPDLLEQLRGQIMRRCPQREQRLARVVRITPRGVLLLIALGLLVHLLLPQLGEVRAALRLMLHAHPLALAATLLGSAATYLLSAVVLRLASNNRVPLGEATAVQVAASFANRLAPGSVGGAALSLRYLHQKGLRAAESATAVVVSRVAGVVSVALLLPVLLPFARRPTRAAEQAVTARALPVLLGVLLVLLAVAAVLAVPQLRRRGRAVLRESIAALRALPRRHRLTRLIGAALALTLAYGFSLYFGLLAVGEPIDLALLAPVILVCVVGEGVASAAPTPGGLGATEAALVSGLLLYGVPVDTAVAGVLLYRLATFWLPAPLGYVALRILARQRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH93</accession>
    <name>F4FH93_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732538.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13795"/>
    <dbReference type="EnsemblBacteria" id="AEB43871">
        <property type="protein sequence ID" value="AEB43871"/>
        <property type="gene ID" value="VAB18032_13795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13795"/>
    <dbReference type="eggNOG" id="COG2089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040465_0_1_11"/>
    <dbReference type="OMA" id="CWDEEAV"/>
    <dbReference type="OrthoDB" id="674753at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006190">
        <property type="entry name" value="AFP_Neu5c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036732">
        <property type="entry name" value="AFP_Neu5c_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020030">
        <property type="entry name" value="Pseudaminic_synth_PseI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51269">
        <property type="entry name" value="SSF51269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03586">
        <property type="entry name" value="PseI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50844">
        <property type="entry name" value="AFP_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFP-like" evidence="1">
        <location>
            <begin position="294"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="36820" checksum="2C58662F11453518" modified="2011-06-28" version="1">MTTLKIGPHLVGTGERPFVVAEMSGNHNGDLDRALAIVDAVAASGAHALKLQTYRPDTITIDVDAPAFRISGGHELWGGQNLYRLYERAHTPYEWHGPIFERGRERGLTVFSSPFDATAVELLERLDAPAYKIASSELVDLPLIRLVAATGKPVIISTGMATLAEIDAAVRTARSAGASGIVLLACTAAYPAPPADSNLRRIPVLAEAFGVPVGLSDHTPGIGVPVASVALGACFIEKHITLDRADGGVDSDFSLNPAELSALVVEAERAHAALGGTAIGPTPAEREGLRFRRSLYVVADVRAGDEVTPANVRSIRPAGGLSPVEIDRVLGRHFTADVTRGTPLSWDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHI3</accession>
    <name>F4FHI3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20275"/>
    <dbReference type="EnsemblBacteria" id="AEB45155">
        <property type="protein sequence ID" value="AEB45155"/>
        <property type="gene ID" value="VAB18032_20275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20275"/>
    <dbReference type="eggNOG" id="ENOG5033NHJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067815_1_0_11"/>
    <dbReference type="OMA" id="TYAWLAS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="298" mass="32090" checksum="6C1C42B55F8D8CD0" modified="2011-06-28" version="1">MPAMATAHRQALRRHLMNEITRPARRPKRTPVLAGAVGVLAAVIAAGTIALPGVPQSAPLVVTVQQAEPAAATTLLNAMAAAVVEKPEPGDGRYVYIRSLGAYAELGGGPARLRPVREREIWIPRYEPGDGLLRQPFFELPVIGVIPERVTLTDMTPNAAVVDLPDDPDELLAKLYRERAERGHGSSRDGAAFTAIGDILRESLVPPQTSAALYRAAARIPGVEVIRQVTDAAGRRGTAVAYTERDRRDEWIFDERTFEYLGSRSYLVADTADGPAGTVLATTAVLQRAVVPKLGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHS7</accession>
    <name>F4FHS7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26866"/>
    <dbReference type="EnsemblBacteria" id="AEB46446">
        <property type="protein sequence ID" value="AEB46446"/>
        <property type="gene ID" value="VAB18032_26866"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26866"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_1_4_11"/>
    <dbReference type="OMA" id="TIAWLHW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="110" mass="12830" checksum="933DE6242BFE0689" modified="2011-06-28" version="1">MLLDAIPAIGGCPGPPRRRPDRLYADRGYDYDSHRQQVRGRGVTPVIARRGTPHGSGLGTTRWVVERTIAWLHWFRRLRIRWEIRDDIHEAFLSLACALICWRQLQRTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHT6</accession>
    <name>F4FHT6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Error-prone DNA polymerase</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">dnaE2</name>
        <name evidence="14" type="ordered locus">VAB18032_26911</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-C family. DnaE2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26911"/>
    <dbReference type="EnsemblBacteria" id="AEB46455">
        <property type="protein sequence ID" value="AEB46455"/>
        <property type="gene ID" value="VAB18032_26911"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26911"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_4_0_11"/>
    <dbReference type="OMA" id="NSWPMGF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01902">
        <property type="entry name" value="DNApol_error_prone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 11 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="13">
        <location>
            <begin position="39"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB46455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1088" mass="118679" checksum="C61E983D909BDA34" modified="2011-06-28" version="1">MVDPLAVDADGGDSPAWSRRREHYSPPELTRPDGVLPYAELHAHTNFSFLDGASHPEELVEEATRLGLTALAVTDHDGFYGVVRFAEAARALHLPTIFGAELTLGLPGPQNGVPDPHGKHLLVLAHGHEGYARLATTIARAHLRGGEKGRPVYGELEEIAADLRDHVLVLTGCRKGHVPAALLTRGVDAAARELDRLTTLFGAETVAVELTDHGHPIDGDRNDALAELATAAGLPTVATGNVHYATPGRRRLATTLAAVRARRSLDEMDGWLPAAGTAHLRSGAEMAARFAAYPGAVARAAEFGAELAFDLQLVAPQLPAYPVPPGHTEMSWLRQLTEAGARERYGPREAHPQAYAQLDHELNMIEALGFPGYFLVVYDIVEFCRRADIYCQGRGSAANSAVCYALRITNVDAVRHRLLFERFLAPERDGPPDIDVDIESDRREEVIQHVYARYGREHTAQVANVISYRPRSAVRDVAKAFGFSPGQQDAWSKQIDRWGDVAAVDVPEIPEQVIAYANEVQTFPRHLGIHSGGMVICDRPVIEVCPVEWGRMPGRSVLQWDKDDCAAVGLVKFDLLGLGMLSALHYGYDMIGMSLDLGEETLDDPEVYDMLCRADSVGVFQVESRAQMATLPRLKPREFYDLVVEVALIRPGPIQGGSVHPYIRRKNGQEPVTYAHPLMRNALEKTLGVPLFQEQLMQLAIDLAGFDAAEADQLRRAMGAKRSVERMARIADRLYAGMAQRGITGELADDVYRKLTAFASYGFPESHAMSFAYLVYASSWLKRYHPGPFLAALLSAQPMGFYSPQTLVDDARRHGVQVRRPDVNASGVKPVLESTAETRWGSQPGEPPHAWGLGGPAVRLGLSGVRTLGEPVAQRIVAERSAHGPYRDMPDLARRVGLTAAQLEALATADAFACFGLTRRQALWAAGAAAQDRPDRLPGTVTGAAAPTLPGMEAVDRLVADVWATGLSPENHPARFIRPQLEAMGAVPIDRLGRVEPGRRIRVGGIVTHRQRPATAGGVTFLNLEDETGMLNVTCSPGLWQRQRRVARTSAALVVRGRLQRHEGVTNLVADRLEAIEPPVRPASRDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHT9</accession>
    <name>F4FHT9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_SAV_6107 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735109.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26926"/>
    <dbReference type="EnsemblBacteria" id="AEB46458">
        <property type="protein sequence ID" value="AEB46458"/>
        <property type="gene ID" value="VAB18032_26926"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26926"/>
    <dbReference type="eggNOG" id="ENOG5032S47">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096112_2_2_11"/>
    <dbReference type="OMA" id="IRSAWEV"/>
    <dbReference type="OrthoDB" id="2046838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040891">
        <property type="entry name" value="HEPN_SAV_6107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18726">
        <property type="entry name" value="HEPN_SAV_6107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_SAV_6107" evidence="1">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="149" mass="15464" checksum="F2C08AC23B037D64" modified="2011-06-28" version="1">MPTSPAQVPTVPAHVLPHRTPAQLLAVARQGLAEAARTSPDGLRYATAHLAALRAAAAVLAARARPAPTRRSRITSVWVLLASVAPELNEWANYFAVAAGKRAAAEAGIPRVVTAREADDLLRAAGDFVTVVESALGMAHQPAIEGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F146</accession>
    <name>F4F146_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07910"/>
    <dbReference type="EnsemblBacteria" id="AEB42700">
        <property type="protein sequence ID" value="AEB42700"/>
        <property type="gene ID" value="VAB18032_07910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07910"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057459_1_0_11"/>
    <dbReference type="OMA" id="ERTMTPP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003308995" evidence="1">
        <location>
            <begin position="31"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="359" mass="36822" checksum="DC1AB34F31BE2970" modified="2011-06-28" version="1">MSRSARRGRISAVAGGVMLLVVAAAGVAASAGVGGGAGGDVAEADTAPAASATVTRQTLADAETVDGELGYGPNRTAASRLAGTITALPDTSATVRRGKALYAVDGDPVTLLYGKVPAYRTLQPGVEGPDVEQLERNLKALGYTGFTVDDEYTWATADAVRAWQDDLGVPETGRVELGRVAYADGPVRVEGHEVEIGAAVQPGQSVLTYTGTDRLVTAELDVDDQRLAKRGEPVEVTLPDGRQVAGKISTVRTVVKSGAANDTSTETKIEVVVAVADQKALAGFDRASAEVTFTVSERPDVLTVPVAALLALAEGGYGLEILDGGSSRIVAVTTGLFARGRVEVSGDGLTEGMTVGMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F197</accession>
    <name>F4F197_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14105"/>
    <dbReference type="EnsemblBacteria" id="AEB43933">
        <property type="protein sequence ID" value="AEB43933"/>
        <property type="gene ID" value="VAB18032_14105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14105"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141544_1_0_11"/>
    <dbReference type="OMA" id="VVTQWES"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="100" mass="10902" checksum="5596568B6664CC2B" modified="2011-06-28" version="1">MKINAIDVPPGAGEELEKRFAARAHAVQNSPGFLGFELLRPVAGESRYFVYTRWESEQAYQDWAAGPARAAHAAPPGAEQRPPVATGTNLLEFEVVQQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1A1</accession>
    <name>F4F1A1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_14125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14125"/>
    <dbReference type="EnsemblBacteria" id="AEB43937">
        <property type="protein sequence ID" value="AEB43937"/>
        <property type="gene ID" value="VAB18032_14125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14125"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008041_0_0_11"/>
    <dbReference type="OMA" id="GANDACR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PTHR21325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="242" mass="26490" checksum="7CC88A976A764432" modified="2011-06-28" version="1">MVAALGDSITTGFGSCLVLTSCERNSWSTGSGLRVDSHYRRLLDRNPGLRDKAYNHARPGARAAALAGQAEAAVRDRADYVTVLIGANDACRGTIEAMTPVAEFRAEVDRGLRVLRDGRPKARVLVVSIPNLYRLWEVGHDDSRAARAWRRGVCPALLADPTSTAPADRARRAAFKERVAAYNRQLSAACRAYGSRCRYDGGAVHRVKFDLDLVNPLDYFHPNTAGQSRLAEVTWRSSGYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Q3</accession>
    <name>F4F1Q3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_27026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27026"/>
    <dbReference type="EnsemblBacteria" id="AEB46478">
        <property type="protein sequence ID" value="AEB46478"/>
        <property type="gene ID" value="VAB18032_27026"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27026"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592898_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="393"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="468" mass="45411" checksum="8136E5E2BC09C6C8" modified="2011-06-28" version="1">MVALAALGAAGHGGYASDPVGAVALAAAATVSIVVAARLGRSGHRTAGRLAAGLAGSLLAYLLLTVLAVAAVAAGQPWAAVTVAAWNSAWIPPLALMQLTASAAVRTSGATPWTHRVVGLTLGAVTLVNAVLTTASEPFAGLPTIAGESWRTALAPVGATATLLGMGALLVLPVTLWRAALGSHETVRARLGIVAAATTAAPLTVAFCLLLAVARAPGGVEPSLGSVAFLVALSGAAAFAAGCALAAARGAAEPRQVTVVVRIAGLTAAALIITGIGTIVAAPGSSLGPTTVALLVSALTVLVGGAAWAGTGLLARTLTPPPPSGPVGPETTPRVEATIAPTHVGAPHLPPADTPSGAEGPVGAADAVAGPTAAGASGAAEGSGGVGVVPEVGSAAVGGLTAREREVLAALAEGASNAGIAAQLVVSERTVDAHLRAIFMKLALTADGTTNRRVQAARIWLEHTRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1R9</accession>
    <name>F4F1R9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_27106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735145.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27106"/>
    <dbReference type="EnsemblBacteria" id="AEB46494">
        <property type="protein sequence ID" value="AEB46494"/>
        <property type="gene ID" value="VAB18032_27106"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27106"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_0_11"/>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="315" mass="32257" checksum="4203EA6B4ED9D983" modified="2011-06-28" version="1">MTLTIGVDVGGTKVAGGVVDDTGTVLVQTRRDTPADDVGKTRDVITELVAELAAGHDIQAVGIGAAGWIDASRSTVLFAPNLAWRDEPLRAYVSAAVGLPVIVENDGNVAAWAEFRYGAARNADDSMVMFTIGTGVGGGIVLGGDLVRGANGIAAELGHMLTVPDGHQCGCGRLGCIEQYASGSALVRFARAAARQEPQRATALLELADGEAEAITGPMVTAAAKSGDPVSAEAFAQVGRWLGTSMADMAQMLDPQVLVVGGGVIDAGELLMGPTRRSYAESLAQRSRLPVAEIRPAELGNAAGVIGAADLARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1S5</accession>
    <name>F4F1S5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735150.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27136"/>
    <dbReference type="EnsemblBacteria" id="AEB46500">
        <property type="protein sequence ID" value="AEB46500"/>
        <property type="gene ID" value="VAB18032_27136"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27136"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="OMA" id="DYWLGGA"/>
    <dbReference type="OrthoDB" id="1337662at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="29533" checksum="858B768D1CA63372" modified="2011-06-28" version="1">MQRPDWAPETIDVERPSVARMYDYYLGGSHNFAVDRAAAQAMVAAVPEAPLMAQANRAFLRRAVQFLCEAGIRQFLDIGSGIPTVGNVHEIAQRHAPDSRVVYVDVDPVAVAHSREILAGNESAAVVQEDLRHPERILAHPDVRAMIDFSQPVAVLVVAVLHFVGEHDRPAEVLRTLRAALAPGSYLVLSQASDDGRSEAERAEAQKVYQRTDNPLWVRSRAELTAFFDGFELVEPGVVWVPQWRPETPDSAEDAERAVFLGGVGRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Y4</accession>
    <name>F4F1Y4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein VAB18032_03235</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03235"/>
    <dbReference type="EnsemblBacteria" id="AEB47731">
        <property type="protein sequence ID" value="AEB47731"/>
        <property type="gene ID" value="VAB18032_03235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03235"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_4_1_11"/>
    <dbReference type="OMA" id="MGNMMKQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="102" mass="10429" checksum="C0798E05B2DDC868" modified="2011-06-28" version="1">MQQMLKQAQKMQQQIAKAQAELAEAEVTGTAGGGLVTATVSGAGEIKSIKIDPKAVDPEDVETLEDLVVAALHNASEAARQLTEQKMGPVAGGMGGLGLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F258</accession>
    <name>F4F258_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08145"/>
    <dbReference type="EnsemblBacteria" id="AEB42747">
        <property type="protein sequence ID" value="AEB42747"/>
        <property type="gene ID" value="VAB18032_08145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08145"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160710_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="239" mass="26160" checksum="E9E89191CA299C8C" modified="2011-06-28" version="1">MVTTGDVSIEVLDNDEKLTERLDAELTAYNRRATGADDEAGLSVRVTGSDGELVAGLTGWTWGGCAGIDMVWVREDRRGEGLGAQLLAAAEQEARRRGCTQLSVASFSFQAPDFYRRHGYLDTGRREGIPGGHVDHQFWKSLVTESADAVRLVALVELAGTAVEAGQRYEDHVLALLNRHGGRVERRLRTGDGRTEVHVIRFDTRAGYTAFLADPQRLALRAELGDAAPQTRVLEVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2B8</accession>
    <name>F4F2B8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="9">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">metG</name>
        <name evidence="13" type="ordered locus">VAB18032_08445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731478.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08445"/>
    <dbReference type="EnsemblBacteria" id="AEB42807">
        <property type="protein sequence ID" value="AEB42807"/>
        <property type="gene ID" value="VAB18032_08445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08445"/>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_11"/>
    <dbReference type="OMA" id="YMRMAGH"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="11">
        <location>
            <begin position="5"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="12">
        <location>
            <begin position="434"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="351"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB42807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="600" mass="66842" checksum="16123E9EB1082542" modified="2011-06-28" version="1">MSHVLAAVAWPYANGPRHIGHVSGFGVPSDVFSRYMRMAGHDVLMVSGTDEHGTPIQVQADAEGLTPRELADRYNRVIVEDLHGLGLSYDLFTRTTTRNHYAVVQELFEGMYRNGYIVPKTTMGAISPSTGRTLPDRYIEGTCPICGYGSARGDQCDNCGNQLDPIDLIDPKSKINGETPKFVETEHFFLDLPALADVLRQWLDTREGWRPNVLRFSKNLLDDLQPRAITRDLEWGVPIPLDDWRERTDKRIYVWFDAVIGYLSASIEWARRSGDPEAWRRWWSTDGAGKDAQAYYFMGKDNIVFHSVIWPALLAGYSGEGSRDGEPGQLGRLNLPTEVVSSEFLTMEGRKFSSSRRVVIYVRDFLERYDADALRYFIAVAGPESNDTDFTWAEFLRRNNDELVAGWGNLVNRSISMAAKNFGQIPAVDPNGLTEADEALLAVARAGFTTVGDLIARHRQKQAIGEAMKVVAEANKYLSDQAPWKLKDEADKPRMGTILHVALQVVSDANTLLTPFLPHSAQKVHELLGGTGVHAPMPVIEQVEDLDGGPAYPVLTGDYTQGARWESVPLEVGRPLAAPKPIFRKLDPSIVDEELARLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2C9</accession>
    <name>F4F2C9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_14445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732668.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14445"/>
    <dbReference type="EnsemblBacteria" id="AEB44001">
        <property type="protein sequence ID" value="AEB44001"/>
        <property type="gene ID" value="VAB18032_14445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14445"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_0_3_11"/>
    <dbReference type="OMA" id="APVREND"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="67" mass="7347" checksum="B22BA2D20B9E8371" modified="2011-06-28" version="1">MAQGTVKWFNADKGFGFITVDGGGADVFVHFSAIQSSGYRTLEENQRVEFEIAQGQKGPQAEQVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2S7</accession>
    <name>F4F2S7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733996.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21210"/>
    <dbReference type="EnsemblBacteria" id="AEB45342">
        <property type="protein sequence ID" value="AEB45342"/>
        <property type="gene ID" value="VAB18032_21210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21210"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_2_11"/>
    <dbReference type="OMA" id="AMPIFAQ"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="416" mass="44469" checksum="13657483AD8B2FA7" modified="2011-06-28" version="1">MVSALTLSACGGGDDSGSSDTVRVTLVNHVWTENIRKALPEFERETGIKVEVTQLGEDQLSDQYNVKLNAGSSDIDVMMYRPLQEGRLFAKNKYLADLTDKAKGSSDFDLADIQAAPLSTTTYEDKVVGVPIITEQQVLYYRKDLLEKSGFSAPPATLDELKAQAAKIQADNPGVAGFVSRTGKAAAVTQFSSFLFSFGGDFVDEAGKSAVSTDAAKQAYAYYGGLLREHGPANISTDMSWSEAMAIFTQGQAAFYTEANSLYKNATDPAKSKVSDTVGFAPFPAGPAGSKPYNVPSWALAVNEASKNQDNSWKFIEWAAGKAQTLEQQKSGVPGARTSVWENPEGIATYPKDMADAITVSLANGVGHDRPVVERVAQAREIVGQPIVDAITGKDAAASAEAANQAFQKFLDDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2U9</accession>
    <name>F4F2U9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="6">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aspC</name>
        <name evidence="6" type="synonym">aspS</name>
        <name evidence="8" type="ordered locus">VAB18032_27436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735210.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27436"/>
    <dbReference type="EnsemblBacteria" id="AEB46560">
        <property type="protein sequence ID" value="AEB46560"/>
        <property type="gene ID" value="VAB18032_27436"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27436"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_11"/>
    <dbReference type="OMA" id="CKQHTVR"/>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="142"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="399"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="6">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="428" mass="46534" checksum="9C5417402076A735" modified="2011-06-28" version="1">MQRILSDQLTRHTGGTVRIAGWVHRRRLLKSVAFLIVRDAAGLAQVVVTDPAVRAEIEALPEETVVEVVATVAANPAAPAGVELTDPTVRPLGPPAVPPPFDLYRPTLTASLPTQLDHAPVALRHPSRSAAVRVSAAAVAGFRATLDAHRFVEIHTPKVVASSTESGANVFALDWFGRPAYLAQSPQFYKQLMVGVVERVYEVGPVFRAEPHDTVRHLAQYTSLDAELGFITDHRDVMAVLRDTLAGMLDTVVDMAGAALATLGVTPPQVPAQIPEVHFTEALRIAGAPADEPDLAPAHERALGEWARREHGSDFVFVTGYPMAKRPFYTHPDPARPDYSNGFDLLFRGLELVTGGQRLHRHADYLTALAARGEPVEPYAGYVDAFRHGMPPHGGFAIGLERFVSRLTGTPNIREVTPFPRDLHRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2X2</accession>
    <name>F4F2X2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735233.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27551"/>
    <dbReference type="EnsemblBacteria" id="AEB46583">
        <property type="protein sequence ID" value="AEB46583"/>
        <property type="gene ID" value="VAB18032_27551"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27551"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694334_0_0_11"/>
    <dbReference type="OMA" id="GRVACCA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="397" mass="39652" checksum="4085C0E87CC823B2" modified="2011-06-28" version="1">MLAAYFADAFRAVVFRAVAVGRAEVAFFAAAVFFAGALVADALVADALVEVVLVAVAFFAGAFFAAVFFAVALVGAFFAVDADTAFRAGAFVADTVLRAGAVLRAGAAVVAFRVAAFFAAVFVAGAFFAAVFVAGAFFAGAFFAAVFVAGAFFAAVFRALVVGRVEVAFFAAVTLFAGALVEVVLVAVAVAGALFAAALVPLALVPLALVAVVLRAAAVEVPVVVGLLAVAVLLAVVAFFAGALLAALFAGALLAAVVFAVVFLAAVVFVGAFFTGVVAAVLVVAEARAPAIVRTAGAVPSARRLDGVRVMPAVRSVAAVLRAGVRFAAGRVACCASAISVPSLGTCHRPRGARGALDAGGVPRRLLLVLPDPASVLGLPRFVALLHLLQGVLRIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F4F395</accession>
    <name>F4F395_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">glmU</name>
        <name evidence="18" type="ordered locus">VAB18032_08505</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08505"/>
    <dbReference type="EnsemblBacteria" id="AEB42819">
        <property type="protein sequence ID" value="AEB42819"/>
        <property type="gene ID" value="VAB18032_08505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08505"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_11"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="17">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="271"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="405"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AEB42819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="521" mass="53462" checksum="51C1A76F998F8519" modified="2011-06-28" version="1">MAARLSASDGSHVVPEPHLRTVVVLAAGEGKRMKSSLPKVLHPLLGRTLLGHVLSAAEPLAAQRTMVVVGHGADQVRAHLAEVAPEAVAVHQAEQLGTGHAVRIALEAAPEATGTVVVLNGDVPLLRPETVAALVAAHEGERAAATVLAAEVPDPTGLGRVVRDAAGRLEQIVEQRDATADQLAIREINAGIYAFDAARLRDVLGKLSTDNDQGEEYLTDVFGLLGSAGEPVVVHLAADHTETLGCNDRVELAGLRRLLRDRVNERWMRAGVSLLDPATTWIDVTVALDRDAVVDQNTQLRGGSVVGSGAVVGPDVTLIDTVVHAGATVLRSHAIGAEVGPGASVGPYAYLRPDARLAEKSKVGTFVEVKNSELGAGAKVPHLSYVGDATIGARANIGAATIFVNYDGVNKSRTVVGEGAFVGCDTNLIAPVEVGAGAYVAAGSAISTDVPPGALGVTRAPQRNIEGWVARKRPGTVSAEAAERALQGGSSQVPAASEGEAIHGTAESVGAATEAGDTATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3E8</accession>
    <name>F4F3E8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08770"/>
    <dbReference type="EnsemblBacteria" id="AEB42872">
        <property type="protein sequence ID" value="AEB42872"/>
        <property type="gene ID" value="VAB18032_08770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08770"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046535_0_1_11"/>
    <dbReference type="OMA" id="WDAFVTM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312659" evidence="3">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="313" mass="32635" checksum="C0063B374E3D1C5A" modified="2011-06-28" version="1">MGALLALLMLAGCGSGSGSDEATSSDAGAAAPPMADRGAGEPAQGGSGTATDTRVDQRSIIYTGSLEIKVDDVEAKAREAVSAATRAGGFVGGDQRRSAAADAVAELQLRVPADRFYPVVEELARLGSQQRRQIDTQDVTEETIDLDARIATQRARVDSARRLLAQADSISDLISLENELGRREADLASLEAKKRRLGDLTALSTITVTLVGPNASTTEDEDQLGFLVGLSGGWKVFLASMTVLVTVLGAVLPWLLVFGVPLGLLWWWHRRRRRGRDTGPALVAPVGAPPPSGLAVPGEVSGAPPVPGARSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3I1</accession>
    <name>F4F3I1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14885"/>
    <dbReference type="EnsemblBacteria" id="AEB44089">
        <property type="protein sequence ID" value="AEB44089"/>
        <property type="gene ID" value="VAB18032_14885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14885"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011261_0_0_11"/>
    <dbReference type="OMA" id="KALPWNP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="613" mass="64671" checksum="EB7D1DAB203E753A" modified="2011-06-28" version="1">MSTNPVDHTPHGRDGEARTFAEVGNTVFVGGNFTQIRQTASSPWITQRYLFSYNRTTGVINTAFVPVLDGAVNALIAGPGGTLIVGGAFKNVNGESRRNLVALDPATGETIASWVGRSDGGMIRDMVLHGNDLYLAGAFNWINGTAHSGLARLNASTGAIDPTFNINATVGRHGTGSYAWTIDVTPDGSTMAVGGNFTLVDGLSRNQIALIDLTGTPSVIDWSSEKFVAPCVDPATFVHYVQDLRFGGDGSWFVVGTNGGSGWPAAYCDALIRFETAARGPNQLGTWVNYTGNDTITSVEVADNIIYLGGHFRWLNNPNASDRAGAGAIDRLGIAAVTPATGMPVNWNPGRRGGSALPSGASNWGSAVPVIWRGSDGLYFGHNSDGMANEYHGRLGMFPIAGGRTITPRNPSAASSGHLYLGVTAGELQRVPFDGTTVGTPTTVSQPNYTGAGATWGLGDRIYWSRTVPGSTTGSRIDISMFNGGNVGVPWESSGFNAWYNPANMTGAFFLDGRLYYTRTGANGLYYRYYEVDGNYLGATEFTLPTTGVTWSAVRGLAWVDGKIVYGHTDGSLRSVPFDPTAAPAVSGAASTVLTTAADGLSWSIPRMFFAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3M6</accession>
    <name>F4F3M6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ordered locus">VAB18032_15110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732799.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15110"/>
    <dbReference type="EnsemblBacteria" id="AEB44134">
        <property type="protein sequence ID" value="AEB44134"/>
        <property type="gene ID" value="VAB18032_15110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15110"/>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_1_2_11"/>
    <dbReference type="OMA" id="ECRGLIC"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="217"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="209"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB44134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="426" mass="46175" checksum="4AC7B33E7B89721B" modified="2011-06-28" version="1">MTEHSEPGPFTDIEQALAEIAAGRPVVVVDDPDRENEGDLIFAAELATPELLAFTVRHTSGFICVPLTEDECDRLDLPPMHHTNQDRRQTAYTVTVDAREGVSTGISAADRAHTIRLLADPSTGPADLARPGHVVPLRARPGGVLRRAGHTEAAVDLARLAGLRPAGVLCELVNDDGSMMRLPDLEKFCAEHSLALITIADLIAYRRRIEKQVELVADARMPTEHGVFRALGYRSETDSAEHVALVMGDIGDGRDVLVRVHSECLTGDAFASVRCDCGPQLNAALDRVAKEGRGVVLYVRGHEGRGIGLLHKLQAYQLQDQGRDTVDANLDLGLPADARDYGTGAQILYDIGVRSMRLLTNNPAKRAGLEGYGLTVTGRESLPVRTHPENVRYLRTKRDRMGHLLDVDETAEAPMGRPVAGNEIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3R4</accession>
    <name>F4F3R4_MICM1</name>
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        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">VAB18032_21325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="263358.VAB18032_21325"/>
    <dbReference type="EnsemblBacteria" id="AEB45365">
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="GTRWAVE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="14"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="386" mass="42562" checksum="8E7D8D87D303001D" modified="2011-06-28" version="1">MGWRAGLDDLLARFAHRFGRAEPRRQALTYLVGLLSPLATKNGWTLAEAAGDATPDRMQRLLNRSAWDPDAVRDDLFAYVSEHLGDDDGVLIVDETGFLKKGIKSAGVQRQYSGTAGRTENCQLGVFLAYASPHGRTLIDRELYLPRSWCDDAARRAEAGIAANIEFATKPALGLRMVERAITAGLPARWVTADEAYGQDSKFRTWLQQQRIGYVLAVPCNQRVPTKVGNSRPDVLAANAPALAWKRRSCGNGAKGPRLYDWAVASLPGTTDGHGHWLLIRRSITDPTDLAYYLCFGPADTPDEDLIRIAGTRWAVEECFQTAKTEVGLDHYQVRRYDAWYRHITLVLCAHAYLAVTATHAKKGAPNPMTASSLSPSARSAVSWHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4B2</accession>
    <name>F4F4B2_MICM1</name>
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        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
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        <name evidence="2" type="ordered locus">VAB18032_04215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB47925">
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        <property type="gene ID" value="VAB18032_04215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04215"/>
    <dbReference type="eggNOG" id="ENOG5031TCK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="PRWFTSS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="6684" checksum="016F98D85E043E93" modified="2011-06-28" version="1">MTGAHWRKSSKSGNNGGNCVEVADNLPGVVLVRDSKDRDGGTLAFEPAAWHCFVELAKAGSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4M1</accession>
    <name>F4F4M1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732828.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15255"/>
    <dbReference type="EnsemblBacteria" id="AEB44163">
        <property type="protein sequence ID" value="AEB44163"/>
        <property type="gene ID" value="VAB18032_15255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15255"/>
    <dbReference type="eggNOG" id="ENOG5032IM4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137888_0_0_11"/>
    <dbReference type="OMA" id="TWQEIAF"/>
    <dbReference type="OrthoDB" id="1949876at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="138" mass="14961" checksum="F9271059BD85710E" modified="2011-06-28" version="1">MADSSTTSEDRAHRSYAALQRLTERHAASEQQRRRHTNPYAADPYEAIAVLLALAAGAAQPEPGEEPVDEADLLAALTLFPHLRAEIDTMEAGLFHLARNRGLTWQAIGQGLGLGSAQAAKQRYDRLTARTPPPQPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4N0</accession>
    <name>F4F4N0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732837.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15300"/>
    <dbReference type="EnsemblBacteria" id="AEB44172">
        <property type="protein sequence ID" value="AEB44172"/>
        <property type="gene ID" value="VAB18032_15300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15300"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_31_0_11"/>
    <dbReference type="OMA" id="EITYWID"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="159" mass="17775" checksum="9F43EE18321A7A8A" modified="2011-06-28" version="1">MSDDLRLRAVAEDDLPEFYAHQLDPEAGRMAAFGAADPADTRAFAAHWMRILTDPRNLAWTVTVDDAVVGHVLVFPAEGRTEVSYWIDPARWGRGYATRALAALLREVTRRPLYARTATDNIGSLTVLRRCGFVIRSTERAYAPGRGEEIDEYLLELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4V3</accession>
    <name>F4F4V3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734095.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21710"/>
    <dbReference type="EnsemblBacteria" id="AEB45442">
        <property type="protein sequence ID" value="AEB45442"/>
        <property type="gene ID" value="VAB18032_21710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21710"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007760_0_0_11"/>
    <dbReference type="OMA" id="MAVRANW"/>
    <dbReference type="OrthoDB" id="865313at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1202" mass="125388" checksum="02C225F17B09009F" modified="2011-06-28" version="1">MTRPVQAILVQHAVALLRPLTDAAGDTQARDRLLRGMGWDLSTLAGFDLPAFVDALVRCRDTVARVAARIDAGLDDLGDAAWCLTEIRTAVTAVVDLFDGWRPPPAPGAPGRPAPPHQDADPYRLFLTDLFGYLLDAHLALYAPNLRVALDVLGVRRLVTATAPVTIGGRQARDRRERPYFTVDPVGRLLVDPVGVLRDRLFGPEGPPTLPAEIADALGEPLVRWLTGVGVPASYGTPGVDAAESGLSPAQRDAARRLLHLSWSAPVGAPDETGTDPVGDPLGQATLHLAAGLARDTAQDPLDPPLALVLAPQGTLDATVEYGQWTLQSRLTGLVTPVVVTRDGVRFRPADGSTPPAGAELTGSVELRYASPTPGEPALRLGAPDATRLEVDQLRFTAQGRLTATGPTGDLVLSLDGARLLIAPGDDGFLAAVLPPYPIRIDLDAGLRWSPEHGLTLTAGGGLELALPVGASFGPLHVEHVTAGVRAGSTGLPGGGTTGPVSTAGAEVRLTTDLTVRLGPVTASATGLGVRAALTPADGAGSLGPIDVDLAFLRPSGIGIAVDAGIVTGGGFLLAQDDGRYGGVVQLNFLDQALSAVGLLDTRMPDGSPGFSLLVLISVRFPPVQLGFGFALTGVGGLIGVNRAVRAQAMRDGLADGGLDGLLFPADPIGNAPRLIRDLDRFFPTTVGQHVVGPTVELTWGAQGLLTARLGLFVQFPTPVRVVLAGQLRIALPPGRTEPVALIQVDLVGTLDFGQRTVAIDGVLRDSRLAGFTLTGRMAVRANWGDRPSFLVSIGGFHPRYPQPDTVPVLSRLTLSLGDGNPRLRLASYLAITSNTVQFGARLDLYAGISVPLVGTFAIAAVLSFDALIVLEPLSFAIDIYAMVALTWNGDPVLAVELAGSLTGPRPWRAVGRASFTFLGRHSIRFDVTVGRRAVNPPPLRVNLAERIRAALADPANWTAEPPTGTGPLVTLAESAIAGTEVLVHPLGSLTVRQKVAPLEVTVDRYGTAALAGDVRRFTLGAVTLDGVPARSTPVDDLFPPAEYLDLDDMEKLSAPSFERWPSGFRVDDSALTLPPEPAWRLVAARTEDEVVTRTPDSGSTGQTVTRPIPDDRMKVQAGAGAAAVNGAGAQGVRAFAGPAGDISLAEPLYAVVTATPPTDGALAVLTPARPPARFAQAREALAAQGAGGVRKLIENDDVPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F529</accession>
    <name>F4F529_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ordered locus">VAB18032_28201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735361.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28201"/>
    <dbReference type="EnsemblBacteria" id="AEB46711">
        <property type="protein sequence ID" value="AEB46711"/>
        <property type="gene ID" value="VAB18032_28201"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28201"/>
    <dbReference type="eggNOG" id="COG0423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_11"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="OrthoDB" id="626850at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="7"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="320"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="193"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="203"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="324"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="459" mass="52675" checksum="B0F91B264DC17219" modified="2011-06-28" version="1">MPADRIDAIVSLAKRRGFVFPSSEIYGGTRSAWDYGPLGVELKENVRRQWWKTMVQQRDDVVGLDSAVILARDVWAASGHLDAFVDPLTECQSCHKRFRADHLEEAYAEKHGKPLASLTELNCPNCGNKGTFTEPKMFNGLMKTFLGPVESDEGLHYLRPETAQGIFVNYNNVANAARKKPPFGIAQTGKSFRNEITPGNFIFRTREFEQMEMEFFVEPGTDEQWHEYWLSERWNWYVDLGLSAENMRFYEHPKEKLSHYSKRTVDIEYRFQFGGSEFAELEGIANRTDFDLSTHSKHSGVDLSYFDQTKSERWVPYVIEPAAGLTRAVLAFLLEAYDVDQAPNAKGKMEERTVMRFDPRLAPVKVAVLPLSRNEALSPKAKDLAAQLRKRWVVEFDDSQAIGRRYRRQDEIGTPFCVTVDFDTLDDNAVTIRNRDTMAQERIALDQVERYLIDHLPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5I2</accession>
    <name>F4F5I2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09480"/>
    <dbReference type="EnsemblBacteria" id="AEB43014">
        <property type="protein sequence ID" value="AEB43014"/>
        <property type="gene ID" value="VAB18032_09480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09480"/>
    <dbReference type="HOGENOM" id="CLU_2409978_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313603" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="80" mass="8347" checksum="3167E2D4BF718AB9" modified="2011-06-28" version="1">MTRRQTLTAAASATLGAAALAVPGLSSAGDDKGAAAGVDETIVVHLRDGRSDAMDVFVGESRIEVRDRGLADRLRRAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5J3</accession>
    <name>F4F5J3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731696.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09535"/>
    <dbReference type="EnsemblBacteria" id="AEB43025">
        <property type="protein sequence ID" value="AEB43025"/>
        <property type="gene ID" value="VAB18032_09535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09535"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_1_2_11"/>
    <dbReference type="OMA" id="SNWTEYM"/>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312708" evidence="1">
        <location>
            <begin position="32"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="43109" checksum="DDBAD1D9D914C2F1" modified="2011-06-28" version="1">MRSAFRPLTRRGLLTGTLGSAALLAAGGSLAGCGTPAAQQTEAGCVSEDLSGTEKKLAFSNWPQYMDVDDDDNAKRPSLDGFVSKTGIQVAYTEDVNDNNEFFGKVQNQLAACQGTGRDIMVLTDWMAARMIRLGWIQKLDKANLPNVEANLLPSLRNRPFDVDNHLAVPWQSGLAGLAYNGRVTGELRTLDELLTRPDLKGKVTALTEMRDTMGLMLMSNGHNPSDFTSNQFDDALNKLKRAVDSGQIRRFTGNDYAPDLAKGDIAACIGWSGDIIQLGFDDEQIKFVVPDSGVMLWSDNMLVPNKATHKANAEALINYYYDPAVAAQLAAYVNYICPVQGAQAEMEKIDPELAANPLIFPDEAILSKARVFMALDEKQEREYETKFQQVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5R3</accession>
    <name>F4F5R3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15830"/>
    <dbReference type="EnsemblBacteria" id="AEB44276">
        <property type="protein sequence ID" value="AEB44276"/>
        <property type="gene ID" value="VAB18032_15830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15830"/>
    <dbReference type="HOGENOM" id="CLU_3367962_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="35" mass="3793" checksum="141E54AF18A6B3DD" modified="2011-06-28" version="1">MPSTELQGSCGVFTTTLTRFYPAAATRLAMALWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F658</accession>
    <name>F4F658_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735459.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28696"/>
    <dbReference type="EnsemblBacteria" id="AEB46810">
        <property type="protein sequence ID" value="AEB46810"/>
        <property type="gene ID" value="VAB18032_28696"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28696"/>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679053_0_0_11"/>
    <dbReference type="OMA" id="IYIADGH"/>
    <dbReference type="OrthoDB" id="591335at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="401" mass="42231" checksum="9A272ED1856429C8" modified="2011-06-28" version="1">MTVVHPITRAWITTGGTGAQNYDEFADDAEITAIIEANPHSALGIEMPHRAPESLGKTFGDALPDAVTRLAEAKADGSYTPAEQVVVLYRITAPGEEPAYGIFAMVDTDQISTRADEPGLVIRNEDVFIAKVRERVALAEALGHLLSPVLLLQTGRGDELHAALATATDAAGAPAATDTDQAGRTHAIWLLGPGPEQDELTALASGGELVVADGNHRSLAAQTGGFRRFLAVVTTPASVAIQPYNRLVSELPTTPDELLDRLRAAGAQITAVDGPVQVPATGGSVVLQLPGQAYDVTLPHTGAGRLENLDHALVERLLLREALGLDPGDKRITYVGGDYPASWLTGEVEAGRAELAILIAPVTVDDFVAVNLAREKMPRKSTWFTPKARGGLVVAELPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F659</accession>
    <name>F4F659_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735460.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28701"/>
    <dbReference type="EnsemblBacteria" id="AEB46811">
        <property type="protein sequence ID" value="AEB46811"/>
        <property type="gene ID" value="VAB18032_28701"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28701"/>
    <dbReference type="eggNOG" id="COG2761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087602_1_0_11"/>
    <dbReference type="OMA" id="KTPVDFW"/>
    <dbReference type="OrthoDB" id="996965at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="207" mass="22777" checksum="46DFDE743A570725" modified="2011-06-28" version="1">MNERSSVDMWFDPICPWAWITSRWLLEVEQVRDIEVRFHVMSLSVLNEGRELPEQYQEAMRTGWGPVRVCIAAQQRYGPAVLGALYTALGTRIHLGKERVGPELFAAALTDAGLDPQLAAAAEDSRLDTALRESHEQGMRPVGTEVGTPVIHAPGPDGRQVAFFGPVVTPAPKGEAAGRLWDGVLLVSGTPGFFELKRSRDLEPTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6C4</accession>
    <name>F4F6C4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">secA</name>
        <name evidence="20" type="ordered locus">VAB18032_09760</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09760"/>
    <dbReference type="EnsemblBacteria" id="AEB43070">
        <property type="protein sequence ID" value="AEB43070"/>
        <property type="gene ID" value="VAB18032_09760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09760"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_11"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="1"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="73"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="404"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="879"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="911"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="962" mass="106325" checksum="F111263CB6774D4A" modified="2011-06-28" version="1">MVRRLKAIAAAVNSIEDDYVNLTDEELSGMTEQFRERLAEGETLDDLLPEAFAVCREAAARVLGQRPYDVQVMGGAALHFGNIAEMKTGEGKTLTSVMPVYLNALSGKGVHVVTVNDYLAQRDAAWMGRVHQFLGLTVGVVLPNRPASEHRAAYECDITYGTNNEFGFDYLRDNMAWSKDELVQRGHNFAVVDEVDSILIDEARTPLIISGPAEHSARWYGEFAAVVARLQAGKDGEGDYEVDYAKRTIAVTERGVAKVEDRLGIDNLYESVNTPLVGYLNNAIKAKELYKRDKDYIVSDGEVLIVDEFTGRILHGRRYNEGMHQAIEAKEGVEIKQENQTLATITLQNYFRLYDKLSGMTGTAQTEAGEFNKVYKVGVVTIPTHRPMVRQDRADVIYKTEKAKFNAVIEDIAERHQAGQPVLVGTVSVENSEILSQLLRRRGIPHSVLNAKFHAREAEIVAQAGRKGAVTVATNMAGRGTDILLGGNAEFLAASELRQRGLDPVENAEEYDKAMEEVLPKWKQACEAEAEEVAAAGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLQDELMKRFRSGAVEAVMERFNIPEDVPIESKMVTRQIKSAQAQIEGQNAEIRKNVLKYDEVMNQQRQVIYAERLRVLNGEDLSEQVRNMIDDVIEAYVQGATSENYAEEWDLEQLWASLKQLYPVGITIEEMEEEAGGSRAGIDADFLISRLRADAHAAYDRREEQLGAEGTRQLERMVLLQVIDRKWREHLYEMDYLQEGITLRAYAQRDPVVEYQREGFAMFATMMEGIKEETVGFLYNLEVQVNEPEPEEEEVQLLDKPVEIRAKGLGRAPQQQGLQYSAPTIDGEAGAGAVAVQRDDQRAPALGIGGPEPDAPAAPGRTAPAAPQRQANGLRGAGVASSTARQTAANGQAAASNGPSRNAPCPCGSGRKYKRCHGAPGGTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6F6</accession>
    <name>F4F6F6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TipAS antibiotic-recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_09920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB43102">
        <property type="protein sequence ID" value="AEB43102"/>
        <property type="gene ID" value="VAB18032_09920"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="HAGHRRY"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="28803" checksum="908E4EC8AF9958DE" modified="2011-06-28" version="1">MAYTVGQVARLAGVTVRALHHYDQIGLLSPSGRTGAGYRRYSDADLERLQLVRYYRELGFPLEQIAEILDDPAGDRDAHLRRQHELLTVRIKRLQEMVTAIEFAMEANKLNIPLTPQERFEVFGDFEPEAYAEEAEQRWGGTDAYRESNRRASSYSKDDWLRIKGETEDWGRRIVALMASGAPADGPAAMELAEEHRQHISRWFYECSYEIHTGLADMYLADERFLAHYEAMAPGLGQYLHEAIHANAITRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4F727</accession>
    <name>F4F727_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735540.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29101"/>
    <dbReference type="EnsemblBacteria" id="AEB46891">
        <property type="protein sequence ID" value="AEB46891"/>
        <property type="gene ID" value="VAB18032_29101"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29101"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_5_11"/>
    <dbReference type="OMA" id="SEHTVKQ"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="16"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="25608" checksum="B084D43D4437416E" modified="2011-06-28" version="1">MDADALASMTPGRPVGVAIVDDHPVVVDGVRAWLATEPRLTVLATGDDPDEVLRAAPEADVVLLDLRLHGRLVLDKLAELSAAGRRVVVYSEHSDPPTILAALDAGAVAFLAKHEGREHCVATVLDAASDRPYVAPALAGAMVGDSRPDRPMLSDKEREALLLWFQSMSKASVARRMRISEHTVKQYVDRARIKYSRVGRPAATKAALLARAIEDGLVRPEEIGIYRSQASAEWPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F784</accession>
    <name>F4F784_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731813.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10120"/>
    <dbReference type="EnsemblBacteria" id="AEB43142">
        <property type="protein sequence ID" value="AEB43142"/>
        <property type="gene ID" value="VAB18032_10120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10120"/>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_2_0_11"/>
    <dbReference type="OMA" id="HAWFERL"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="2">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1082" mass="117145" checksum="47BCBD8DC70F953D" modified="2011-06-28" version="1">MGTQSGAALIGREHPAGLLRAELDRATASHGGLVLVGGEPGIGKTTLVTAVADEARRQGALVLGAACWDSASAPGYWPWLQVLRGLRRSAADWAVARESAEPALALLHGEPAGHRMVSGSHGEGDAVEQEAFALYDAVTTALVAVSQRRPVVVVLDDLHWADAASMRLLQFAAQHTWFERLLFVGTYRDAEVEAGDHPLRPLLMSLTAKATPITLTGLSRDEVGVLIARVTGQEPTADCVDDVYRRTGGNPFFVEQTARLWHVDGAASGIAPGVREVVRRRLDHLPEAVVHTLVVAAVLGREFHRAVLAAGAGLPPTRLDQLLDVAVSARLVLAQPDGGYAFAHDLVRETLYEGLTDDDRNDHHAAVVRAVDEHAALAERLVPADLARHAWLAGDRLDPYRCADLLIAAARDASCRLALEESTVHLRRALVVSRNEVQRVRIMIELADRLFHTGDQAEASRLLAETTVQALAVDEPALMARFALSVYRHCQLTSRPEIDTEALVREAYRRLVGEPGSDVPVETLEVGLINATEELARRNQDDDALSVSLWARHDAAWGPGTAANRAALTAEIREVARRSGDQETPLWATSLRWVALLELGDPRYLDELTAFVTAGRQAGKVRHQMAANIDSGIISAFRGDFAAAEACYAELRSPVAESSSGLWWEGWEDDKHLFIDLHLIWSLLLLRGRLDEAQALLDGLDPAEHQFLDLLHAVTAAERGGHRHAARITARLEAAGGTYPSVILPLWLRLQAQVTVTAPDRCEAARQALLPYRGQWLVAVYGCDISGPVDHWLAVVDAADKRWDDAVAGFTAARDNADRMGSRPWSLIASTALADALIARDGPGDSAVAAGLRREAEREARGLDMRQVLARLAAPTPVGSSPAPAGGPSPDSGSGAGTTTPAYEFCRDGAVWRLTYGGTTAYLPDTKGLNDLHLLLGCPGVDVPAVGLLDPAAGPELVAARRLGGDEILDEEARNRYRRHLALLDDEIDRAAMRDDTARVATLDDERRALIGQLRSAAGLAGRHRRLGDEAERARKTVTARIRDTLRRLDQQHPPLAAHLRQTISTGTACRYQPTEPVPWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7F7</accession>
    <name>F4F7F7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">abyA3</name>
        <name evidence="3" type="ordered locus">VAB18032_16450</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16450"/>
    <dbReference type="EnsemblBacteria" id="AEB44396">
        <property type="protein sequence ID" value="AEB44396"/>
        <property type="gene ID" value="VAB18032_16450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16450"/>
    <dbReference type="eggNOG" id="ENOG50335F6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196618_0_0_11"/>
    <dbReference type="OMA" id="WDSVHLL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEK75499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="78" mass="8404" checksum="E67BDB5B304AE16F" modified="2011-06-28" version="1">MSTLRSVHDFVTLVRDELGLPIEESDLDRHLDDVAGWDSVHLLALCSALERATGRSISLPAVLTADSLGGIYATAVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7J2</accession>
    <name>F4F7J2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733091.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16635"/>
    <dbReference type="EnsemblBacteria" id="AEB44431">
        <property type="protein sequence ID" value="AEB44431"/>
        <property type="gene ID" value="VAB18032_16635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16635"/>
    <dbReference type="eggNOG" id="COG3640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852393_0_0_11"/>
    <dbReference type="OMA" id="GCVCPAS"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="34533" checksum="BA9826F420582E74" modified="2011-06-28" version="1">MKIAFVGKGGSGKTTLAALFARHLAAGDRPVLAIDADINQHLAVALGASEEAAAQLPALGDALPQIKEYLRGDNPRITSAAAMVKTTPPGAGSRLLRVAESNPVYDCCVREVGGVRLAVTGAFSEEDLGVACYHSKVGAVELLLNHMADGPAEYVVVDMTAGADSFASGLFTRFDLTVLVCEPTVRSVGVYRQYAGYARDYGVALAVVGNKIENTADVDFLREHVGADLLTWVSRSAYVRRAERGIVDPLDALEPANRAVLTQLADAVDATGQDWEEFTRHAHEFHRRNAHAWANERAGTDLTAQIDPDFVMGPAARLPVRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7J9</accession>
    <name>F4F7J9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733097.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16670"/>
    <dbReference type="EnsemblBacteria" id="AEB44438">
        <property type="protein sequence ID" value="AEB44438"/>
        <property type="gene ID" value="VAB18032_16670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16670"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561201_0_0_11"/>
    <dbReference type="OMA" id="WPGWNTT"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313650" evidence="1">
        <location>
            <begin position="29"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="486" mass="50496" checksum="9641C7EC458DDCA3" modified="2011-06-28" version="1">MRARGFAALVAGAVVVAGTMLAPTAASAAEKVVLSKGHTDAVDVHFEDGALSLKVNDDTVSPAVTRDPADVTFQVLPEAAMAVPDDSRFAFLGPAGSRIWLLPMTQDPRLLWPGWNTTTLKTGVFEGNKVRLSLVDVQGPGTVTLFTQDSFGGPIIKFRDDDGLPDTIDVPVKTHAHSNWAFSALGSYTLKFQADATLTDGTTVSTGPVDYSFVVGELSGSGPQVSLSVSGMADEYQPNDTVTLTAVQTPQTELDHYHWFSRCPGTADWAVIAGEAGPSYSFTATRELNACEYLAKLYDDDHTVAATSEPVTLWVAFPPQDPGRSQTITASIDETQGSLVISVNPDDRAVVLPPAQLSPGGDRWESNGELRPVTVTDTRAGQPGWSASGQIPTDFTAPDGATFSAGYLGWSPRVLAQGAGQGVVAGPEVAPYVVGSGGGLGTSAVLGTAPSGNGRGTAQLSAGLRLSLPTETAAGTYTATLTLTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7K1</accession>
    <name>F4F7K1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_16680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733099.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16680"/>
    <dbReference type="EnsemblBacteria" id="AEB44440">
        <property type="protein sequence ID" value="AEB44440"/>
        <property type="gene ID" value="VAB18032_16680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16680"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032280_1_0_11"/>
    <dbReference type="OMA" id="PGWNTQH"/>
    <dbReference type="OrthoDB" id="746749at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022395">
        <property type="entry name" value="CHP03773_ABC_transptr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03773">
        <property type="entry name" value="anch_rpt_wall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307478" evidence="3">
        <location>
            <begin position="29"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="530" mass="54174" checksum="57F74D82A8358402" modified="2011-06-28" version="1">MTMRSLRAGVAGLALTVLALTTGTTPAAAEPAGITTDGADLVSLALHGDSMSLRIRDAAQVAHDVPGHDPAEVILGPDGGLAGRVPPGKAFAFLGPTGHPVWSLSAGDTGFPALDTTGVRPGVVVDDTVALTLRSVEGPGEFAAYTLAGIGEASPLFGSRPGVTRTAHLPVGMRTGGVVWVFDAAGDYRFTLTGSSTLRSGRKVSADATYRVHVPTISPAEQAPLPAVRQPVPPEGQSAPRPLAAPAAAPKPEATPKPAVAPPVKAATTAAGARQVIADGHVDMGPQLSADTWTIRIKDDRSSPPVWRETADVVLQVKDNAKITVPAGAEFLGKQGDTVWLLPQSQQAGIVWPGWNTQHQSVVSGVKGTVTWALKGVNGPGRFALFLTGSFGKADVLFDSAKPFPQQLSVPLNTHAHGNWAFTEPGLYRLAVQMSGTTTAGKAVTDTKTLTIAVGDRTDPTSGFGPDSGSGGGGDNDGKEQGAGSLPRTGTGWVLSAAAAGVVLVAVGTVLMLLTRRRRAGLADTARANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7P0</accession>
    <name>F4F7P0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734329.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22885"/>
    <dbReference type="EnsemblBacteria" id="AEB45677">
        <property type="protein sequence ID" value="AEB45677"/>
        <property type="gene ID" value="VAB18032_22885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22885"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="LDKYATH"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="24488" checksum="CA1338563D3E9424" modified="2011-06-28" version="1">MTDPTPSTTRPVRILLADDQPLLRTGFRMVLGAEPDLDIVAEAGDGAEAVELSRRLLPDVVLMDIRMPRMDGVSATRAIVDARLPVRVLILTTFELDEYVVGGLRAGASGFLSKDVPAEDLITAIRTVAAGDAVVAPRILRRLLDRFADVLPDPAASPPKALSTLTDREREVLGQVARGLSNAEIARALSVSETTIKTHVGNVLTKLGLRDRVQAVVLAYESGLVRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Q9</accession>
    <name>F4F7Q9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734348.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22980"/>
    <dbReference type="EnsemblBacteria" id="AEB45696">
        <property type="protein sequence ID" value="AEB45696"/>
        <property type="gene ID" value="VAB18032_22980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22980"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OMA" id="VDLWQVH"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="34287" checksum="74053817DABBD521" modified="2011-06-28" version="1">MQQRPLGRSGLAVSRLALGTMTWGRDTDADDAAAQLKSYLDAGGNLVDTADVYGDGDAESVIGSLLGGLVPREELLIATKAGLRPGGSRRRDGSRGHLLRTLDASLRRLGTDYVDLFQVHGYDPQTPLEETLAALDHAVASGRVRYVGVSNFSGWQTARAAAWQAAWPGRAPVVAAQVEYSLLERGVEREVLPACDALGLGVLPWSPLGRGVLTGKYRHGRPADSRAVSPHFERFVATYLEPRCSSIVEAVATAAGGLGVSPLEVALAWIRDRPGVTAPILGARTCGQLLGALQVERMTLPEEITTALDDVSAVEVGYPERDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7U0</accession>
    <name>F4F7U0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase type i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734379.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23135"/>
    <dbReference type="EnsemblBacteria" id="AEB45727">
        <property type="protein sequence ID" value="AEB45727"/>
        <property type="gene ID" value="VAB18032_23135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23135"/>
    <dbReference type="eggNOG" id="COG5553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102185_0_0_11"/>
    <dbReference type="OMA" id="TTRWYHR"/>
    <dbReference type="OrthoDB" id="1571420at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="154" mass="16867" checksum="EE347A72D4EFFC3D" modified="2011-06-28" version="1">MPALPVSERSDLLAVARRWAGDPGSWPVPLRFDPASRWYARLAADDDHEVWALSWLPGQGTDLHDHGGSSGAFLVCSGVLTEETVSGGRLRPHLLDAGSGRRFGPRHVHVVTNRHAEPAVSVHVYRPALRRMTRYHLDGGRLRAAEVAEAGVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8A2</accession>
    <name>F4F8A2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731934.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10725"/>
    <dbReference type="EnsemblBacteria" id="AEB43263">
        <property type="protein sequence ID" value="AEB43263"/>
        <property type="gene ID" value="VAB18032_10725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10725"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_11"/>
    <dbReference type="OMA" id="VHPGNMV"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="312" mass="32764" checksum="2B0178B88E46C474" modified="2011-06-28" version="1">MTVSDQHDDLSFGIDSTATEVLAGIDLSGKVAIVTGGYSGLGLATTRALAAGGARVIVPARRTDVAREAVAGIDGVEVDELDLADLDSVRAFAERFLASGRSIDILINNAGIMATPLTRVGPGWEAQFATNHLGHYALVNRLWPALTADGGARVVVLSSGAGENPRINWDDVHFADGYDKWAAYSQSKSANILFAAELDRLGRAAGVQAFSVNPGYILTPLQRHLAKEEMVGAGWIDEEGNALLPEFRAPEQGAATQVWAATSPALAGDGGAYLQACKVAKTFDGPEDREAAERLWALSAELTGVDAFGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8A9</accession>
    <name>F4F8A9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10760"/>
    <dbReference type="EnsemblBacteria" id="AEB43270">
        <property type="protein sequence ID" value="AEB43270"/>
        <property type="gene ID" value="VAB18032_10760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10760"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_11"/>
    <dbReference type="OMA" id="SHRVPWK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="37093" checksum="5C962FCA36437F2D" modified="2011-06-28" version="1">MVTGAAGMLGTALLARDWPGVTWTGVDIRPLAPRVRDRAGFIQADVRDADAMTRAFRRADVVIHSAAALPSHRSADIRSVDVDGTVSALEAARRAGVDRFVHISSTAVYGLPRDCPTPEDYPCEPVDPYSAAKLGAENAVLRHRAQGLCAPIVRPKTFLGEERLGLFAMLFEWADEGRHFPLIGGGDVATQMLDVEDLCAAIQLICEAPDDTANDTFNIGAREFRTLREDFQAVLDAAGHGKRVLAMPVGPAVAVLRVLAATRLSPVYKRLVHKLTRDSYVSIDRAVQQLGFSPRFSNEQALLKTYDWWRANAAGTRRSAGRTHRDPWKQGALSLAKALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8C3</accession>
    <name>F4F8C3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44468">
        <property type="protein sequence ID" value="AEB44468"/>
        <property type="gene ID" value="VAB18032_16820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16820"/>
    <dbReference type="eggNOG" id="ENOG5030W3G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1502872_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="18460" checksum="B44124579DCCD79D" modified="2011-06-28" version="1">MVSAMSETVVPATRNRRGTIALVLACISLVLSLVMCCGAGLVASTSGIDLLPVQSTPQVASAAQVEAVAHVTLPPGTVLLTAAYSNGLETVLSAKFRIPRTELDVFIATAKFTAAPVPGLRAVDAKHNVGGGDLWDPEAAKSVSGVDEEQPTADGTRRAVLFNLDAPDAVTVYLYASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8P6</accession>
    <name>F4F8P6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_23455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734441.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45789">
        <property type="protein sequence ID" value="AEB45789"/>
        <property type="gene ID" value="VAB18032_23455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23455"/>
    <dbReference type="eggNOG" id="COG2154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860017_0_0_11"/>
    <dbReference type="OMA" id="MEGDNQR"/>
    <dbReference type="OrthoDB" id="1519464at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="34158" checksum="F4F391E1D6ACB645" modified="2011-06-28" version="1">MRKQMEGDNQRRRALARQARERGRQAADTGASLSASKQLTHLDQSRRSGPPAAGQRHKPNTTRGGPAPPSAGVPQTSRPLPEAGVGNPGVTTMGYQDLVADVGRRAGVDFRTAKVGVESTVLVLAWALGTAERQRLLAAVPASLHDVVPVDGIERREDLPGFLSEVGRISGRSPEQARYQAEATLAALAERDGDLVESLHVPDQLRELLEPMAVGGGLVGASSATAPLTGSELAAALDALPYWSGDDEVLTRTLELPSDNLDRVLDRLDQLRVQTGRGPRIGRADPTTAVLTVRTGNAGGVTALDVDLAHTIDAAIDEAGAGLNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8U5</accession>
    <name>F4F8U5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MmpL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_29771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735673.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29771"/>
    <dbReference type="EnsemblBacteria" id="AEB47025">
        <property type="protein sequence ID" value="AEB47025"/>
        <property type="gene ID" value="VAB18032_29771"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29771"/>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005108_1_1_11"/>
    <dbReference type="OMA" id="AGMTMLN"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313691" evidence="7">
        <location>
            <begin position="36"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="194"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="746" mass="76434" checksum="7D847AAE2ADEC3ED" modified="2011-06-28" version="1">MATLLYRLGRGSMRRRRLVAAIWLVVLVALGLAAATLRGPTASNFSMPGTESQRAIDLLAEQFPAAAGATGTIAVKAPNPGQLGTPEGQAVVQKVTEEATAVPGVVGAVNPFQVGAVSPDGQYALIQVQFSGGVDTVTDEQRDAYEKVGTQAQAEGWQVAPGGEVLNAEPEVGSTEAIGVAVALVVLIITFGSLVAAGMTMLNALIGVGVGMAGLFALSSVVELTSTAPILALMLGLAVGIDYSLFITSRYRQNLLDGLPADEAVGRAVGTAGSAVVFAGATVVIALAGLAVVNIPFLTVMGLAAAGTVTVAVLVAITLQPALLGFAGGRVLPRRLRSSVAVTTEDSSRIADGAGSASTDHAAPEAATLAGEDRSAFGFRWARLITRFRIPVILVGVIGLGLLALPASDMRLALPDAGTAPAGTPARVSNDLITEGFGPGFTGRLAVVVAGDDAQATTAAIPQVTNLVQGTENVLAVAPPQLSPDGKTALLGVIPQTGPTDPATETMVHDIRAAVADVPGADVLLTGVTAVGIDISEKLSDAMPVYLGLVVGLSILLLMLVFRSLLVPVKAALGFLLTVAATFGLTVAVFQQGHLADLVGLDTPGPLISFLPILLIGILFGLAMDYEVFLVSRMREDFVHGDTAQQATINGMGHGARVVTAAALIMTSVFGGFVFLDDPVIKSMGFALAVGVAIDAFVVRMTIVPAVMSLLDKAAWWLPRWLDRGLPNVDIEGEKLRATLDNKATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8X8</accession>
    <name>F4F8X8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735706.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29936"/>
    <dbReference type="EnsemblBacteria" id="AEB47058">
        <property type="protein sequence ID" value="AEB47058"/>
        <property type="gene ID" value="VAB18032_29936"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29936"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_0_0_11"/>
    <dbReference type="OMA" id="PMLWVSN"/>
    <dbReference type="OrthoDB" id="1381894at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="93"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="312" mass="32617" checksum="CCF77CEB9D802E07" modified="2011-06-28" version="1">MSTAAHPLWRPVSGCGPDCLPLPGHAPTVPPARQLGRAVALLGMLGLGIGLAAVLPVLPAREPHAATRGWARATARACGVRLTVRGRLPRRRALVVANHVSWWDVLAILAVAPARLVAKREVGRWPLIGLLVRAAGTLFVDRSRPRNLPAAVARVAAALRAGRTVAVFPEGTTWCGRQTGCRPVTGFRPAMFQAAIDAAAPVVPVRIGYRDATTGTSTSVGAFIGDETLLRSVRRLLAARHLQVTVEIGAALHPGRDTDRRALARVAESAVHLVPAAAGAPPRTVDPVPAAHRPTPARLPADPSGRGLSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F917</accession>
    <name>F4F917_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">VAB18032_04595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730719.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04595"/>
    <dbReference type="EnsemblBacteria" id="AEB42045">
        <property type="protein sequence ID" value="AEB42045"/>
        <property type="gene ID" value="VAB18032_04595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04595"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062999_1_1_11"/>
    <dbReference type="OMA" id="AHIINIR"/>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="105"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="28834" checksum="6F46E3A60BFB42B1" modified="2011-06-28" version="1">MAAKTSRNVASEIAFLTRALKAPSLAASVERLAERARAESWTHEEFLAACLQREVAAREAHGGEGRIRAARFPARKSLEEFDFEHQRSLKRETIAHLGTLDFVASKENVVFLGPPGTGKTHLSIGLGIRACQAGHRVAFATAAQWVSRLADAHHAGRLQDELVKLGRIPLLIVDEVGYIPFEAEAANLFFQLVSNRYERASLIVTSNKPFGRWGEVFGDDVVAAAMIDRLVHHAEVISMKGDSYRLKDRDLGRVPAATKTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F962</accession>
    <name>F4F962_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_04820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730764.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04820"/>
    <dbReference type="EnsemblBacteria" id="AEB42090">
        <property type="protein sequence ID" value="AEB42090"/>
        <property type="gene ID" value="VAB18032_04820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04820"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_3_1_11"/>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="495" mass="52208" checksum="EA8302F548AF97B2" modified="2011-06-28" version="1">MTAAATPASSPATAGERPGVRLARSRRNAELSLLLLAMALVAAYGAMVEANVLDTVTPNFWVPAAVLTAVFLGIHVAIRFLAPFADPALLPAVALLNGLGVGFLRRLDLGNAAPEERADLAIFAGTGGRQLAWTLLSVLLAAGLLALVRDHRSISRYAYTLGLAGIVLVMLPAVLPASISEINGAKLWIRIGSFSIQPGEFAKLALLAFFAYYLVRKREVLSLASHRFLGIDFPRGRDLGPVVVVWVISLLVLVFQKDLGTSLLYFGMFVATVYIATERVSWLLIGLVLFFGGAYLAYVLGKSIGGPFLNFSVRADIWLDPFAKPYDEGYQLVQGLLALGTGGLFGAGPGGGQPTELPEVQNDFIFAGIGEEIGLFGLSALLVIYLLIVERGLRAGLAVRDSFGKLLAGGLAFTLALQVFVIVGGISKLIPLTGQTTPFLSAGGSSLMANWLLIAVLLRVSDAGRRPVTGGGKVNRPSGGPPEQLHGAPTEVIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F987</accession>
    <name>F4F987_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase of the TIM-barrel fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731952.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10815"/>
    <dbReference type="EnsemblBacteria" id="AEB43281">
        <property type="protein sequence ID" value="AEB43281"/>
        <property type="gene ID" value="VAB18032_10815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10815"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044590_4_2_11"/>
    <dbReference type="OMA" id="ICQQKGN"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="14"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="293" mass="32094" checksum="EBA6CE4699EDE90E" modified="2011-06-28" version="1">MYQPAIDLDAVTAIDMHVHIEVDDHGHASLPEPLVAAVSKYFRTDGPRPAVDAVAQYYRERNMAAVVFTVDARTQLKHPPLSSADIARAAAEHADVLIPFGSVDPRTGEAALELAARLISDEGVRGFKFHPTVQGFDPSHEKYAPLWALIERAGLPAIFHTGQTGIGAGTPGGYGLRLGLSNPMLLDPIAADFPDLQIIMAHPSVPWQDEALSVATHKHNTWIDLSGWSPKYFPAELVRYANSMLKHRVLFGTDYPLITPDRWLRDVAATDLKPDVLPGILKDNAARLLRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9G2</accession>
    <name>F4F9G2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_11190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11190"/>
    <dbReference type="EnsemblBacteria" id="AEB43356">
        <property type="protein sequence ID" value="AEB43356"/>
        <property type="gene ID" value="VAB18032_11190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11190"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_11"/>
    <dbReference type="OMA" id="DPFPVHG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="331"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="470"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="775" mass="81346" checksum="9FC2FA48D1749C8F" modified="2011-06-28" version="1">MIGAAVLSALVAIVAGVLLAAAARRRSGPHRQAYVLFTGAAAVSLVTLLLATAGALSASEHWAHEQPQRTSWASAVAVGTAVSGLLFCAGLLRMPGVAGSVGAAARLALDSVVVGAALWFVGWVLLSEPTRVLGDATPMACPAILLASISAALCSGLAIILVLRARPPRRGLAVLGAGISVATSGGLGVATGLCQVGPAMTSMSLVVLAVGLLTAAVAMSRIDPAGQLTTDVIRHDGEYAFVPMAAMAGSAMYHLLQDGRFDALGIVAGSVEGFALVARQHLTLHQVRAYARRLAEREAHFRQLAHTDALTGLANRRGLLRALHGCAAADTPCMLLSLDLDGFKNVNDMRGHDVGDAVLVEVGQRLRANLRPGDLAARLGGDEFAVLMHGGPAEAGAVAERLLKVLGGAYPQPEGPVFCSVSIGLATWADTPDVELLLRHADLALRYAKQRGKNRIERYDGAYDRLLRRRTTLEHELRGAIGRNELRLVFQPVASLPSVRPVGAEALLRWHHPELGNVRPDEFIPLAEESGIIAELGAWVLHEACRQLSRWLAEGHDVWVSVNVSPRELHAPAYVAQVTEALRTHHVPPQRLVLEVTEHAVATDLDELIRRLTALRRTGVRIALDDFGAGYSSLGQLRRLPIDILKIDHGLVAEHEPVRPVGRDGPAFAPMVDIVMRLGHQFGLEVIAEGVTTPTELAAVVAAGCRFGQGALFGWGVPAEHLEAMLEAATSPGARPARPGNPASGPTPAPRVGNGTSEHVKPGAGGLSGGGTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9N0</accession>
    <name>F4F9N0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733263.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17530"/>
    <dbReference type="EnsemblBacteria" id="AEB44608">
        <property type="protein sequence ID" value="AEB44608"/>
        <property type="gene ID" value="VAB18032_17530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17530"/>
    <dbReference type="eggNOG" id="COG3828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100195_0_0_11"/>
    <dbReference type="OMA" id="AGWHGGI"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="236" mass="25925" checksum="07BA6B7EF3FF1560" modified="2011-06-28" version="1">MTRRRALVVRGGWEGHRPVEATDLFIPFLEVNGYTVRVEGSTEIYADATALADTDLIVQCMTMSQITGEQVAGLATAVAAGTGFTGWHGGIVDSFRACSDYLHLVGGQFATHPSVPPCDRRGGEQDAFLPHSITITDHGRQHPITAGIEDFDLVTEQYWVLHDDLIDVLATTTHPTREWQPWHRPVTSPAIWTRHWGAGRIVVTTPGHSLDVLEHPSVRTVIERGMVWATRTASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Y6</accession>
    <name>F4F9Y6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase sdr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00065"/>
    <dbReference type="EnsemblBacteria" id="AEB47097">
        <property type="protein sequence ID" value="AEB47097"/>
        <property type="gene ID" value="VAB18032_00065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00065"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_11"/>
    <dbReference type="OMA" id="KPLDQQV"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="36116" checksum="B423711B5130B259" modified="2011-06-28" version="1">MTGDTVGYRYLMPLVRPISDSTVVITGASSGIGTATAYALARRGCALVLAARTEPALLAVARRCDELGGRSLVVPTDVTDPAAVERLAASAVAQFGRIDAWINNAAVGVVGLFDEIPVAEFRRVLEVDLLGTAYGMRAALPHLGATGGGVVVNNASVLAEVAMPYQSAYNAAKHGIRGLSDTVRQELRLTGRGDISICTVLPAAIDTPFFRHAANHSGQVFAPPPPVYPPTMVAETIVRLLQRPRREAYAGGAARLLGLQWRLAPALTERVLAWYAQRTQFGPGAPADSSGNVFRPDADGVPEGGWHGRRRQVVRVTAALGLAAAGTAVGTVAAMARQRRQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA68</accession>
    <name>F4FA68_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730803.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05015"/>
    <dbReference type="EnsemblBacteria" id="AEB42129">
        <property type="protein sequence ID" value="AEB42129"/>
        <property type="gene ID" value="VAB18032_05015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05015"/>
    <dbReference type="eggNOG" id="COG5164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_315634_0_0_11"/>
    <dbReference type="OMA" id="HSSPKAH"/>
    <dbReference type="OrthoDB" id="2080220at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="853" mass="87138" checksum="F6A9706566DC7A92" modified="2011-06-28" version="1">MTSEGPHHPGHEPDEVPPGGGGSAPYGDRPVQQENGYGAPASDLGWAPPPPARPDQAAPAWASQPGAGWGNQQANRQAQAPSAGTWTPAGGQQSWNPPGEQPAANWPAASTSDQPAWANAGQSNPAWGGAPTSESTQPAEWTPHQTSSDQSASSQSGSPPASWQGNQQPEWNTAPRPGEQPPGWAAGAPESAQPDWAQAKPAQPDWAQANPPSQSERAQSNSPAQPNWTQSSPPAQPDWAQGSAPAQPDWAQGNSPAQPDWAQAKPAQPDWAQANPPAQPDWAQTSPAAQPEWAQGGPSAQPDWAQTDQAATRGEPAARATAQVPPADPAPQQHSAPGDPARAGAWPGEQQEQPGWPVGQGRQPEPAGWAQDQAPAWTPTEAASGSASPLPSRNAADRAPLTEIEPWAPGEAWGGGGAPEAGPSRSDTGRAEESPVYQPAPAPGISPANMVPLPPQEQRIPGASLAAAPPADYSAPGQYPGDQSTPGQRPGADQPAGSWGQPESRPDEPKPPAEASIPAPRTSPESVGRATPPTAAAGGVSASASVPTTSRVTPPADHTAIPTSTPAPRVYGRPARPEPEEPVQEREEQPQPPRFGQGPEPRFADHEQAGPSAFTGAAAPASPAFPPGLPAFADAPATDRPVNGVKPHPEPERPADRFGGPAGDPFGSPAGDPYGGAARDPFGGPTDRPGVTYGSPARPESGPDHTSAFPPGPQANAPWSPGTPAAEPEQGRFDAFKPVAEPAADAPPPKVRNGRVLAAVLVAAVLILAIPLGLLLLLGKFGGSDDNAFDPAVGSCVKRSGDSAVEAVCGEPESFSVVSKVESKDKCPDPALPYVELRGDVANPVLCLKNSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAG0</accession>
    <name>F4FAG0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732058.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11355"/>
    <dbReference type="EnsemblBacteria" id="AEB43387">
        <property type="protein sequence ID" value="AEB43387"/>
        <property type="gene ID" value="VAB18032_11355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11355"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_1_11"/>
    <dbReference type="OMA" id="RWNRWAV"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="245" mass="27254" checksum="DD0D3D8718A8949D" modified="2011-06-28" version="1">MGRRRLGFWQWLAVVLVKPVMTIWTRRTWRGMEHLGTEGPMIIVANHMSHADPLVAAHFIYDSGRWPQFLGKASVFKVPVIGWILHRCKQIPVERGTVDAAKSLDALIKALGEGDAVIIYPEGTITREPDLWPMKGKTGAARLALATGAPVVPVVMWGPERIFDPHRSRLNPRPRIPVTVVAGPPIDLSQWAGAAPSRAVLEEMTDVIMLRLRDMLAEIRGGTPPPLWQRGGRTNIEQRRPEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAJ2</accession>
    <name>F4FAJ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein marr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11525"/>
    <dbReference type="EnsemblBacteria" id="AEB43419">
        <property type="protein sequence ID" value="AEB43419"/>
        <property type="gene ID" value="VAB18032_11525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11525"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_0_11"/>
    <dbReference type="OMA" id="EMAREVH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="146" mass="16697" checksum="37D1218C3265589D" modified="2011-06-28" version="1">MDDDLPERLREVEDELTALLRRGRALSWEIASEVHPNLEPNAYGLLLWLRRSGAIRLTDLAARLGVGKGTLSRQIHSLETLGLVRRDPDPSDRRAAQLSLTEEGQRRFDAARAPRLGQIRRALQSWPQQDVEELARLLRRFNDAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAN2</accession>
    <name>F4FAN2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733302.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17725"/>
    <dbReference type="EnsemblBacteria" id="AEB44647">
        <property type="protein sequence ID" value="AEB44647"/>
        <property type="gene ID" value="VAB18032_17725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17725"/>
    <dbReference type="eggNOG" id="ENOG503443H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1721578_0_0_11"/>
    <dbReference type="OMA" id="WGERISR"/>
    <dbReference type="OrthoDB" id="1648755at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025850">
        <property type="entry name" value="SUKH-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14433">
        <property type="entry name" value="SUKH-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="16760" checksum="E73ABE5DD78F5F7A" modified="2011-06-28" version="1">MQRPVSFYRRTRDILKQVGWSAGRAVDTAQWEADLEADGFLPLHPVARRFLTEFGGLTVHNSEPGVTRAREPFTLVPTECSGEADRFIGWGERISRDIAPIGELAGGTCGCALLGIDEQEEIYLVTDGLATFGRLPRAMDHLALGYMPRKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAN3</accession>
    <name>F4FAN3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_17730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733303.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17730"/>
    <dbReference type="EnsemblBacteria" id="AEB44648">
        <property type="protein sequence ID" value="AEB44648"/>
        <property type="gene ID" value="VAB18032_17730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17730"/>
    <dbReference type="eggNOG" id="COG1062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_11"/>
    <dbReference type="OMA" id="LNWAPSC"/>
    <dbReference type="OrthoDB" id="1859760at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="358" mass="36789" checksum="81FE378F1DB8694D" modified="2011-06-28" version="1">MRGLVARAAGTPPRVEQVDLPDIDTGQVRVTIRAAGVCHSDLSMVDGTIAAPYPLLLGHEAAGVVVEIGDGVDRVAVGDHVVLNWAPPCRACWSCTHGEPWLCEHTGTPATEAGHTLDGEPLHVTLGLGALAEQVVVPQQAMVVVPTDLPFPTAALLGCAVLTGVGAIRRTAAVRPGDSVAVIGLGGVGLSAVAAARAAGAATVIAVDVSPAKADLAHAAGATDFLLADDTLSRAVRTLTGGRGVDHAVECVGRAATIRTAWRATRRGGQVIVVGMGGKDDIVGLSALEIFHSARTLRSSVYGSSDPDRDLPELARSVLDGSFDLDFLVSDRITLDEAPEALARMARGEGARTVVQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAT4</accession>
    <name>F4FAT4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17985"/>
    <dbReference type="EnsemblBacteria" id="AEB44699">
        <property type="protein sequence ID" value="AEB44699"/>
        <property type="gene ID" value="VAB18032_17985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17985"/>
    <dbReference type="HOGENOM" id="CLU_3141985_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="49" mass="5615" checksum="D1315F4F478B4DE6" modified="2011-06-28" version="1">MAVLLSRMEQLDEAIECQRRAVDLAEQSSHPAKEEMRAFLVQLEQTKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAV2</accession>
    <name>F4FAV2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoglucanase</fullName>
            <ecNumber evidence="6">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_24085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734567.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24085"/>
    <dbReference type="EnsemblBacteria" id="AEB45915">
        <property type="protein sequence ID" value="AEB45915"/>
        <property type="gene ID" value="VAB18032_24085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24085"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012932_2_0_11"/>
    <dbReference type="OMA" id="THGIQWF"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313728" description="Endoglucanase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="9">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="477" mass="51085" checksum="A0490A986CE31124" modified="2011-06-28" version="1">MKHPPSRPRRLLVAAGTVGALTLGALAALPAANAMAATGCSVTYTTNSWSNGFTANVTVTNLGDAIGNWTLGFSFPDSGQRVTQGWSAIWSQSGNAVTARSESWNGNLATGASTSIGFNGSFTGNNPSPTSFTLNGVPCTGSTTTPPPTTPPPTSPPPTTPPPTGQTPVQINGQLRVCGVNLCNQYGRPIQLRGMSTHGIQWFGNCYNNASLDALATDWRADLFRIAMYVQEQGYETDPAGFTNRVNNLVEEATRRGMYAMIDFHLLTPGDPMFNLERAKTFFAAVSARHASKNNVIYEIANEPNGVSWSTIKNYADQVIPVIRANDPDAVVIVGTRGWSSLGVSEGANHTEIVNNPVNASNVMYAFHFYAASHRDNYRAEVERAAARLPLFVTEFGTVDYTGDGGVDLASSTQWLDLLDRLKIGYANWTFSDKAEGSAALRPGTCNGSNYTGTSVLTPSGVFMRERIRTPDNFPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAV3</accession>
    <name>F4FAV3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24090"/>
    <dbReference type="EnsemblBacteria" id="AEB45916">
        <property type="protein sequence ID" value="AEB45916"/>
        <property type="gene ID" value="VAB18032_24090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24090"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="CDRTVHW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="23083" checksum="C25C21A493512DFB" modified="2011-06-28" version="1">MTGRALAASQVSASYGSQRVLDRVDLHIAAGETVGLSGPSGSGKSTLARLLALLHRPDSGHVSLDGTAVTGTRHQVPVAMRTRVAILFQSPRAATDPRLTLADIIAEPLRATGTPPEQARERTAELADTVGLTTDLLTRRPHAVSDGQLQRACLARSLVHRPAYLLCDEATAMLDASTQAHVAAVIGEYQRRHSAGVLVISHDAALLARWADRVVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAV9</accession>
    <name>F4FAV9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="4">G6PD</shortName>
            <ecNumber evidence="4">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zwf</name>
        <name evidence="8" type="ordered locus">VAB18032_24120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24120"/>
    <dbReference type="EnsemblBacteria" id="AEB45922">
        <property type="protein sequence ID" value="AEB45922"/>
        <property type="gene ID" value="VAB18032_24120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24120"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_1_11"/>
    <dbReference type="OMA" id="QCWRIVE"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 4" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="6">
        <location>
            <begin position="27"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="7">
        <location>
            <begin position="195"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="490" mass="52892" checksum="90CE5AFBCEB099D2" modified="2011-06-28" version="1">MTTSAPIASPAAPAMPATTRIPQTLLVLGASGDLTGRLLLPGLGRLVASGALPGLRLIGSGMDDWDDERWRRRVTESFATVGADGPRETELIRQSWYVPADVTREEDLRRLLGDCSGPLVIFFALPPMVAARSAAALARIGVPPGTRLMLEKPFGVDRISARSLNNLLATLVPEEQVHRIDHFLGKSTVLNLLGLRFANRIFEPVLNSTHVACVDIVFDETLGLEGRAGYYDGAGALVDMVQSHLLQVLALLTMEPPPSLEARELRGRLAQVLRATRLWGDDPVASSRRGRYTAGEIAGRRLPSYVDEPGVDPARGTETLAELVLTVDTWRWAGVPFRLRSGKAMAGVRKEAVITFKQPDRVPDGLTGYERPDRLRIGFGPDRLGLDLNINGPGNPFDLDQVDLMAEFGPGDLPAYGEVLRGAFDGDPTLSVRGDVAEECWRIVEPVLAAWKAGAVPLRDYPAGSTGPADSLLGPATGWRPPRPAARNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB37</accession>
    <name>F4FB37_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family 5 extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735827.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00490"/>
    <dbReference type="EnsemblBacteria" id="AEB47182">
        <property type="protein sequence ID" value="AEB47182"/>
        <property type="gene ID" value="VAB18032_00490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00490"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_11"/>
    <dbReference type="OMA" id="SSWGDPQ"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312860" evidence="1">
        <location>
            <begin position="25"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="81"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="534" mass="58328" checksum="836FC49B952C5F48" modified="2011-06-28" version="1">MRVRRLAAWTALPLAVTLGLVACGSGGNGGSGESDPNAAVRIEIAEPQHLVPTNTNETSGSQVLSALFSPLVDYDEAHKPYEVAAESITSEDNTTWTVKLKDGYTFHNGEDVTADNYIDAWNYGAYAPNGQNSSYFFEKIAGFDDLQGETPKTTTLSGLKKVDDHTFTVTLSQPYSEFKSILGYTAFYPLPKAAFSAPGVLAEGYEQAPIGQGPFKMKGTWQHDAKVEVERYDAFPGEQPKVAGVEFRIYQQLTAAYADVLSDNLDVIKTIPTENLSTASVDLGDRFQQSPASSLHFLAFPTFQEEFSNPDVRKAISMAIDRDEITKSIFKDSQQPARSFVSPVVAGYRDNTVGTAGEFDPAKAKELYESAGGPSKITLSYNGDGGHKDWIDATCNQLKANLGVDCVGNAEPKFADLLTKVKAKQPVGLFRMGWIMDYPSMENYLGPLFSTNGSSNYYGYSNPEFDKLLAEGVSAPSEEEAIKKYQAAEDLLAQDMPVVPLRFGQNNFGHSTKVKNVEVDLFDRVDLVKIEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB51</accession>
    <name>F4FB51_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ordered locus">VAB18032_00560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735841.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00560"/>
    <dbReference type="EnsemblBacteria" id="AEB47196">
        <property type="protein sequence ID" value="AEB47196"/>
        <property type="gene ID" value="VAB18032_00560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00560"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_11"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="30199" checksum="A1ECE09FFE21FF5A" modified="2011-06-28" version="1">MAIWLTKESKVIVQGMTGSEGSKHTRRMLAAGTNVVGGVNPRKAGTTVDFDGAELPVFASVSDAMKETGADVTVIFVPPQFTKGAVIEAIDAEIPLAVVITEGVPVHDTAAFWAYNVAKGERTRIIGPNCPGIASPGASNAGIIPADITGAGRIGLVSKSGTLTYQMMYELRDIGFSTCVGIGGDPIIGTTHIDALAAFEADPDTDAIVMIGEIGGDAEERAAEFIKANVTKPVVGYIAGFTAPPGKTMGHAGAIISGSAGTADAKKAALEAVGVKVGKTPTETAKLMRELMSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB81</accession>
    <name>F4FB81_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ordered locus">VAB18032_00710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00710"/>
    <dbReference type="EnsemblBacteria" id="AEB47226">
        <property type="protein sequence ID" value="AEB47226"/>
        <property type="gene ID" value="VAB18032_00710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00710"/>
    <dbReference type="eggNOG" id="ENOG5032S23">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106245_6_0_11"/>
    <dbReference type="OMA" id="AKAKTMC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="129" mass="14483" checksum="080F2A3B9F18CF92" modified="2011-06-28" version="1">MLMSNVRRLPGPIVDLWDWQRLGACRGRDSAQFFHPDGERGSSRLRRESGAKAVCRACPVRAECAAHALTVREPYGVWGGFSESERLRLLAVGWEDLADRRQTRVDVARLEARLGSSHRSTVPTQRNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB96</accession>
    <name>F4FB96_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="12" type="ordered locus">VAB18032_00785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735886.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00785"/>
    <dbReference type="EnsemblBacteria" id="AEB47241">
        <property type="protein sequence ID" value="AEB47241"/>
        <property type="gene ID" value="VAB18032_00785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00785"/>
    <dbReference type="eggNOG" id="COG0692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_3_1_11"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="OrthoDB" id="1260295at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="59"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="233" mass="25035" checksum="397BCAA6B340DE33" modified="2011-06-28" version="1">MPDDVVILDLPALLPSEWREVLAPHLDPARTAALGEFVAREYATGTVFPPVEDLFSAYRLCAPSACRVLILGQDPYHRVGQAHGLSFSVREGVSVPPSLRNVFKELGEDLGVPKPANGNLDGWAAQGVLLLNSVLTVRQGAPGSHANRGWEEFTDATIRALDTMESRVVFLLWGGYARKKAALVGNPQHVVLEAGHPSPMNPRGFLGSRPFSAANKALADAGLPTIDWERTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBF4</accession>
    <name>F4FBF4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3883 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730923.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42250">
        <property type="protein sequence ID" value="AEB42250"/>
        <property type="gene ID" value="VAB18032_05620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05620"/>
    <dbReference type="eggNOG" id="ENOG5033J6I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1947676_0_0_11"/>
    <dbReference type="OMA" id="PENYYLY"/>
    <dbReference type="OrthoDB" id="1933154at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="DUF3883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3883" evidence="1">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="14835" checksum="9ED0161F1FAE6E5B" modified="2011-06-28" version="1">MGGNEVERIAIEYVMQLEIRNGRVPEDVHLTKAPYDVSSPPRKIEVKAFGGSARSAAVPLEDRQFQAARQDPENYYLYVVDNVARADEGLMRVRVIHGDALTKLLDGAKPHITYWPTFRAQAYDDAEHLGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBH7</accession>
    <name>F4FBH7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007075222.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11625"/>
    <dbReference type="EnsemblBacteria" id="AEB43439">
        <property type="protein sequence ID" value="AEB43439"/>
        <property type="gene ID" value="VAB18032_11625"/>
    </dbReference>
    <dbReference type="GeneID" id="5703986"/>
    <dbReference type="GeneID" id="67459617"/>
    <dbReference type="KEGG" id="vma:VAB18032_11625"/>
    <dbReference type="PATRIC" id="fig|391037.6.peg.1221"/>
    <dbReference type="eggNOG" id="ENOG503161G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148679_0_0_11"/>
    <dbReference type="OMA" id="YETDMEL"/>
    <dbReference type="OrthoDB" id="1837954at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="107" mass="12869" checksum="858785F4B77F9100" modified="2011-06-28" version="1">MSAEDLEKYETEMELQLYREYRDIVRQFSYVVETERRFYLANQVDLHVRNSDGEVYFEVEMHDAWVWDMYRPARFVKNVRVMTFKDVNVEELEKPDISLPADSGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBR8</accession>
    <name>F4FBR8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733373.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18080"/>
    <dbReference type="EnsemblBacteria" id="AEB44718">
        <property type="protein sequence ID" value="AEB44718"/>
        <property type="gene ID" value="VAB18032_18080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18080"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064087_0_0_11"/>
    <dbReference type="OMA" id="IEPCFDN"/>
    <dbReference type="OrthoDB" id="1616423at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031020">
        <property type="entry name" value="Endura_MppP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04462">
        <property type="entry name" value="endura_MppP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="69"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="379" mass="41045" checksum="5DE3E4400FE85D2F" modified="2011-06-28" version="1">MSPSTPLLRGVNLTEIESLALSSQLNMADGHARQELTKAQRSIVDELPDLFAKAAAQPVDDLEREAHRAYLHLLHQHSYPTRPGGVLTCYSSSVAMEILARSLVPAGGGPVALVHPTFDNIPDLLRGNGLRLLPVEEDVLHEGSVSAAVPEGVRCLFITTPNNPTGRVLAEQRLAAIAAECAARDVVLALDTSFRGFDTRSHYDHYAVLRDSGCRWVVIEDTGKLWATLDLKVGLLASSDHVGLPLAKIHSDILLGVSPFVLVLVTRFAEDAAAGGLADLHRFIADNRALVRATLADVPDLAFPDGDARVSVERVDLGERRCLDVWTRLRQSGIYVLPCSQFHWADPARGDHSLRIALARVPGALEAAVRALRAVLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBY5</accession>
    <name>F4FBY5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein GntR, HTH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734635.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24425"/>
    <dbReference type="EnsemblBacteria" id="AEB45983">
        <property type="protein sequence ID" value="AEB45983"/>
        <property type="gene ID" value="VAB18032_24425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24425"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_16_4_11"/>
    <dbReference type="OMA" id="WATINRA"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="8804" checksum="88263A6663090029" modified="2011-06-28" version="1">MPTPRKFEPHYRRIIADIRARVASGEWPPGHKLPSTKALAEMYGVNSQTTVRQAVTILIETGELYGHQGLGVFVAEQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBZ2</accession>
    <name>F4FBZ2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734642.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24460"/>
    <dbReference type="EnsemblBacteria" id="AEB45990">
        <property type="protein sequence ID" value="AEB45990"/>
        <property type="gene ID" value="VAB18032_24460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24460"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_1_1_11"/>
    <dbReference type="OMA" id="WQEIGRL"/>
    <dbReference type="OrthoDB" id="1175355at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="22152" checksum="15F470111CE74ECC" modified="2011-06-28" version="1">MTAVHPSEQPADVSETIAAGRILPVVVLDDARAAAPLGAALAAGGLRSVEVTFRTDAAADAIRAMAEDPQLLVGAGTVLTPGQVDDAVAAGARFIVCPGFSARVVAHCQQVGVPVFPGAATPTEIQMALDAGLDTVKFFPAEQLGGTTMIKALAAPFRSVRFIPTGGVNTGNLRDYLSLPPVLAVGGTWMVAPSLLAEGRWDDVTALTAAAVTAAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCF3</accession>
    <name>F4FCF3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730953.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05770"/>
    <dbReference type="EnsemblBacteria" id="AEB42280">
        <property type="protein sequence ID" value="AEB42280"/>
        <property type="gene ID" value="VAB18032_05770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05770"/>
    <dbReference type="eggNOG" id="ENOG50328YQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2721168_0_0_11"/>
    <dbReference type="OMA" id="RKHWWNG"/>
    <dbReference type="OrthoDB" id="1884284at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="88" mass="10483" checksum="BF0280A425E2E8A6" modified="2011-06-28" version="1">MEQRKHWWNGKWGRLARRDVFLRTDADRWYVEQRAGGAEGVSRFYEYDTLDDAEETIRALLHPTDPWRELSPRPPSPWTTTPTPPSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCH1</accession>
    <name>F4FCH1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_05860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05860"/>
    <dbReference type="EnsemblBacteria" id="AEB42298">
        <property type="protein sequence ID" value="AEB42298"/>
        <property type="gene ID" value="VAB18032_05860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05860"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_0_11"/>
    <dbReference type="OMA" id="KNTINVM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="107"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="296"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="388"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="480"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="572"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="664"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="756"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="1052"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1331"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="973"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB42298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1457" mass="156970" checksum="B41EB3B8799D14B3" modified="2011-06-28" version="1">MMTTAKQSATAEISVADHEAVLTELAEALRRVRGGDLKVRLPRRSGAAGEVADAFNDVVSLQERQHLDLRRISRIVGRDGRLTERLDEEGLDGSWAEGQRAVNSLIDDLGRPTTEIARVIVAVADGDLSQHMALEIDGRPLRGEYLRIGRTVNTMVDQLSSFSNEVTRVAREVGTEGKLGGQADVRGVAGTWKDLTDSVNTMASNLTGQVRSISQVATAVAKGDLSQKITVSARGEVAELADTMNSLTDTLRLFAEQVTRVAREVGTEGKLGGQAEVPNVAGTWKDLTDSVNSMASNLTAQVRNIAQVSTAVARGDLSQKITVAAQGEILELKDTVNTMVDQLSSFADEVTRVAREVGTEGKLGGQAQVRGVSGTWRDLTENVNQLAGNLTSQVRNISQVSTAVAKGDLSQKITVDARGEILELKDTVNTMVDQLSSFADEVTRVAREVGTEGKLGGQAQVKGVSGTWRDLTDNVNSMASNLTSQVRNIASVTTAVAKGDLSQKITVDARGEILELKNTVNTMVDQLSSFADEVTRVAREVGTEGKLGGQAQVRGVAGTWRDLTDNVNSMASNLTSQVRNIAQVSTAVAKGDLSQKITVDAQGEILELKNTVNTMVDQLSSFADEVTRVAREVGTEGKLGGQAQVKGVSGTWRDLTDNVNSMASNLTSQVRNIASVTTAVANGDLSQKITVDAQGEILELKNTVNTMVDQLSSFADEVTRVAREVGIEGKLGGQAQVKGVSGTWRDLTENVNQLASTLTTQLRAIAQVSTSVTRGDLTQRIAVKAQGEVAELKDNINQMIVTLRETTHKNAEQGWLDSNLARIGGLLQGQRDLGEVCRMIMMEVTPLVDAQLGAFFLADNSEGVMRLRLTASYGYVSRGHEVTFGPGEGLVGQTALSRRTIRVGAVPDGRITLRSGLADTPPADLVVLPVLFEGELLGVIEFASVTPFSELHLSFLERLVATIGIAVNTIQANRRTEELLAQSQRLAHELQEQSAELQRTNAELEEKATLLSEQKGNIETKNREIEMARLGLEEKAQQLTRASAYKSEFLANMSHELRTPLNSLLLLARLLAENSERNLTPKQIEFARTIHGSGSDLLRLIDDILDLSKIEAGRMDVEPTEVRFEEIRSYVEQAFAPQAEEKGLDFQVRVAKDLPPAVVTDAQRLQQILRNLLSNAVKFTDNGAVTLRISRAPEHAVFDVPALINARQVIAFTVIDTGIGISDDKLSLIFEAFQQADGTTSRRYGGTGLGLSISRDLARLIGGTITVSSAPNQGSTFTLYLPDVLAPDAVVAPAPPSPQRAGLPSSLLMPPVELLPQQPEAPKTRQLDGATVLIVDDDVRNVFALTSALELHGMTVLYADNGNDGVRLLAEHPEVDIVLMDAMMPDQDGYETTRQIRRNHRFADLPIVFLTAKAMPGDRESAIAAGASDYITKPVDLDELIELMGSWISGSRTEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCL4</accession>
    <name>F4FCL4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731014.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06085"/>
    <dbReference type="EnsemblBacteria" id="AEB42341">
        <property type="protein sequence ID" value="AEB42341"/>
        <property type="gene ID" value="VAB18032_06085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06085"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651829_0_0_11"/>
    <dbReference type="OMA" id="DLTTWVQ"/>
    <dbReference type="OrthoDB" id="2141429at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313793" evidence="2">
        <location>
            <begin position="32"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="395" mass="40879" checksum="4D04CA795F1E43D1" modified="2011-06-28" version="1">MIFRTRRATSLAAAALLASSAVAAFGAPAHAAGTETDLAVTAAGTRMTDGVEGKFAWIKVANQGEGTPSKLLVKVDVSKVDDNKMVLVPVTFGGCDITGDSKLELFTCELDKDEIPGPGETTEVLVFLVKMDADVTGPYTAPVTISIESADDTDDSNNSIDVDVELTPESGVDLGVVVPDVKTRFDLDTLEEKGPLRPGDTTLVGSLVMNQGNQTAKGLRLTYQLPKGATFLAIDGCEADDDGRTVVCEDKNYLLEPDRYLEFPLPITVDEDLEAPATLKGGSLAVTAFGALPVDAPAIHKGAAKPAFARAQVRKVEESDFADLDPSDNTDDFAVILPAPAGGGGGGGGLPVTGVQAGLIGGVGAAVVVAGAVLFLLSRRRRVVLVTPGDEKTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCM5</accession>
    <name>F4FCM5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732188.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12025"/>
    <dbReference type="EnsemblBacteria" id="AEB43519">
        <property type="protein sequence ID" value="AEB43519"/>
        <property type="gene ID" value="VAB18032_12025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12025"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_2_11"/>
    <dbReference type="OMA" id="IQLATWR"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="21016" checksum="F469D7A2F08173BF" modified="2011-06-28" version="1">MALGFVRPARPEDAGEIARIQLATWRVAYRRLLPRHVLANLDEAMLAQRWEAAVRQPPSENHRVLVAVEQAEQSYLVGFAASGPVDAEALAPNEPAEALGPDVVAVTDLLVEPRWGRRGHGSRLLAASVDLWRESGFSTALAWVFEGDQASRKFLTAAGWEPDGAGRALDVDDMLVPQLRLHVAVPTEPTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDC8</accession>
    <name>F4FDC8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47339">
        <property type="protein sequence ID" value="AEB47339"/>
        <property type="gene ID" value="VAB18032_01275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01275"/>
    <dbReference type="eggNOG" id="ENOG502ZZCS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019218_0_0_11"/>
    <dbReference type="OrthoDB" id="1451505at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="30115" checksum="D354E9420B335A19" modified="2011-06-28" version="1">MALRDWLPEIIQQVQPWISSEDIDKGQRWAIEVGAKLGEMSQGLICVTPDNLREPWLNFEAGALAKSIDDSRVRPVLLGVQPSELTGPLALFQATVATDREDMFRLVASLNAACSAPLDTGRLERAFERNWDDYLRKLSAVEEAELGQPEVSAKRSQEDMIGEILERLREVQRSVESARNVEGELRPQEILLADGTPVRTGMRVFVPGWGIGRVARAISVATFGAPNEGMLTLYLHNGEVLERVRASDLRRPTPEEHAVAGTIPLQDVGTANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDM9</accession>
    <name>F4FDM9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731065.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06340"/>
    <dbReference type="EnsemblBacteria" id="AEB42392">
        <property type="protein sequence ID" value="AEB42392"/>
        <property type="gene ID" value="VAB18032_06340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06340"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119460_0_0_11"/>
    <dbReference type="OMA" id="GVIRMSW"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="144" mass="15421" checksum="0EB810C630564D1E" modified="2011-06-28" version="1">MATVRLSFSPAPVHVRTARLVGVAVARRAGVREDLLDEVRLAIGEACTRAVALHRQYGVAEPVLVEMSDSGTYAVRVVDRAPIEASIGLAALDADQLANESLNEDDLTTGVGFALLAGFVEDLQVRPVDDGIGTEVRMVWPLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDY3</accession>
    <name>F4FDY3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732332.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12750"/>
    <dbReference type="EnsemblBacteria" id="AEB43664">
        <property type="protein sequence ID" value="AEB43664"/>
        <property type="gene ID" value="VAB18032_12750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12750"/>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_3_1_11"/>
    <dbReference type="OMA" id="VVEQDCV"/>
    <dbReference type="OrthoDB" id="1777515at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="146" mass="15964" checksum="B19634D394D0180A" modified="2011-06-28" version="1">MPSTQLRVAGFADLDARTFHDLVRLRVDVFVVEQECAYPELDGRDVEPGTRHLWLARDGAVLAYLRILADPDGVARIGRVVVAPSARGAGHAGRLVVAALAEIGDRPCVLEAQSHLVDFYARHGFTVSGPEYVEDGIPHTPMRRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDY6</accession>
    <name>F4FDY6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding domain 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_12765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12765"/>
    <dbReference type="EnsemblBacteria" id="AEB43667">
        <property type="protein sequence ID" value="AEB43667"/>
        <property type="gene ID" value="VAB18032_12765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12765"/>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047929_3_0_11"/>
    <dbReference type="OMA" id="STWDYYI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-3" evidence="3">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="233" mass="24560" checksum="243521BA9204B29D" modified="2011-06-28" version="1">MVATLAVAAPAQAHGYVSSPPSRQALCAQNRVPDCGQIRWEPQSVEGPKGLRNCHANISHFAVLNDDNRGWPATSVGTTVTFTWVNTAMHATRDWEYYIGNTRVAVFSGGGRQPGPTVSHSVNLSGYSGRQKLLAVWNIADTANAFYSCVDLQIGGGGNPPPSPSPTTPPAPSPTPTVAPTSNPPAGGTWTAGRAYAVGDQVTYGGRTYRCRQAHTAIAGWEPPNVPALWSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE40</accession>
    <name>F4FE40_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733564.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19035"/>
    <dbReference type="EnsemblBacteria" id="AEB44909">
        <property type="protein sequence ID" value="AEB44909"/>
        <property type="gene ID" value="VAB18032_19035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19035"/>
    <dbReference type="eggNOG" id="COG0798">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_11"/>
    <dbReference type="OMA" id="CTAMVLM"/>
    <dbReference type="OrthoDB" id="1493959at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="379" mass="40519" checksum="66D8F960F722558C" modified="2011-06-28" version="1">MTATPAGATPPAVVARLSRLDRFLPLWIGLAMAAGLLLGRLVPGLNTALDAVTIGGISLPIALGLLIMMYPVLARVRYDRLDSVTGDRRLLLSSLLLNWVLGPALMFALAWIFLAEHAEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSVFQVVAFGLLGWFYLSVLPSWLNLSGAQLQVSGGDIAVNVLIFLGIPLLAGYLTRRLGERAKGRTWYESRFLPRIGPVALYGLLFTIVILFALQGDAITSQPWDVVLIAVPLLVYFAVMWAGAYALGRAIGLSYARTTTLAFTAAGNNFELAIAVAVGTFGVTSGQALAGVVGPLIEVPVLVALVHVSLALRRRLFPAEITTTARRGPAPAVVRSGRTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEC9</accession>
    <name>F4FEC9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25485"/>
    <dbReference type="EnsemblBacteria" id="AEB46195">
        <property type="protein sequence ID" value="AEB46195"/>
        <property type="gene ID" value="VAB18032_25485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25485"/>
    <dbReference type="eggNOG" id="ENOG502Z8UI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640771_0_0_11"/>
    <dbReference type="OMA" id="DHVTLWW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="40717" checksum="B1F5146A12435696" modified="2011-06-28" version="1">MRAQEELSGVVTTIRDLAAKGATASGDVAGIVVEPERNTLRLYWAGTMPETVAAEIGRARSAGITVVVRSAAYTEAELRREVERLVRLPLHSGKPSAQRVMAAMPMPDGSGIKVNIGGLPAGTSVASALRSVPALDSKYPLTVDLSSELVPASRWYDWGPYWGGGYMDRTAGGSCSNAFGVTGLNGVATYLLSAAHCGQGEWRTGAVNFGNGPERNTYGSTITSRALAHDGHAILTPDGAGNAVYHGTPVNPNNNDLGATSGIRVGGASRSTIGELVCTSGSYTGTVCGIRVAATGISYQFDPPAHGVGVMTNMVNAQLPGVSVAGNGDSGGPVYAIRTTDQRAIARGVISAIDLNQERPCTGYVYPGRACSSSVLYGEVVDIMNTIGVRINVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEY3</accession>
    <name>F4FEY3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732363.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12905"/>
    <dbReference type="EnsemblBacteria" id="AEB43695">
        <property type="protein sequence ID" value="AEB43695"/>
        <property type="gene ID" value="VAB18032_12905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12905"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031028_0_0_11"/>
    <dbReference type="OMA" id="EFPFPAW"/>
    <dbReference type="OrthoDB" id="226222at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="588" mass="63203" checksum="54EBA6E2F498BD76" modified="2011-06-28" version="1">MTDPGFDVTGEGAGEGVGRVLGTADATPLQFWTAVAPGSYLQLDDVVVTRRELPDREPVTIAGVVTQVRARHEGAQFDSDVFAIADGTLPAQVQEAAEITTTRVDPEFYVPPQPGAVVHRAEGDARARALHFDRMERRIPMGTGRDGVPVYLNADFLDGTRGAHVSISGISGVATKTSFATFLLYSVFRSGQLGGDAVNAKALIFNVKGEDLLFLDHPNNRLDDATRAAYARLGLVADAFGDVRVYAPPRVGDSSGTPDVSSRLTGVDSFYWTLSEFCADRLLPYVFADADDERQQYTMVVHSVAAHLARYAQPADGGVSLDGVRLGSYGDLVDHIVEQLSDDETRGEWAGSAVGLGTVNAFARRLIGSKKDLSRLIRGDLATRRPHSINTAESAQVTVVDLHNLPDRAQRFVVGVTLKSEFERKEKAGTAKPLLFVVLDELNKYAPREGSSPIKEVLLDIAERGRSLGVILIGAQQTASEVERRIVTNSAIRVVGRLDPAEASRPEYGFLPPAQRQRALLAKPGTMFVNQPDIPVPLCLEFPFPAWATRVSEAGAAPSQTLRSITQSADPFAVVGSGGGSVDDDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEY9</accession>
    <name>F4FEY9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_12935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12935"/>
    <dbReference type="EnsemblBacteria" id="AEB43701">
        <property type="protein sequence ID" value="AEB43701"/>
        <property type="gene ID" value="VAB18032_12935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12935"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OMA" id="GQHAFEW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="279" mass="30514" checksum="CCA42DE79CB0AB97" modified="2011-06-28" version="1">MKSASRLWRTSPLTYLALVMAALLSIYPFYYMIVIGTRSLDAINDVPPPFTPAGSFGDNFGRVLDNDAANFVTGLVNSVIVSSVVTVSVVLTGSLAGFAFAKLRFRGRNILLLSIIVTMMIPTQMGLIPLWGMMQSFGWYDSLLAVTVPFLVSAFGVFMMRQYASQAISDELIEAGRVDGASTFRIYWNIVLPALRPAAAVLGLLTFMETWNSFLWPYAILSPENPTLQVSLSFLSYAYYTDYSQVFAATAVGTLPLVLVFIVFGRQIIGGIMEGAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEZ2</accession>
    <name>F4FEZ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_12950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732372.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12950"/>
    <dbReference type="EnsemblBacteria" id="AEB43704">
        <property type="protein sequence ID" value="AEB43704"/>
        <property type="gene ID" value="VAB18032_12950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12950"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_11"/>
    <dbReference type="OMA" id="DTVGNRG"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="134"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="248"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="44438" checksum="C572D668A6E3F757" modified="2011-06-28" version="1">MDFGYDARTEQLRAELTDFLDQHVYPAETVHATQVAATGDPWARPPVLAELKAEARRRGLWNLFLPDPRYGAGLTNLQYAPLAELTGRSPHLAPEALNCAAPDTGNMELLAEFGSPAQRERWLAPLLAGEIRSAFCMTEPEVASSDATNIATSIRRDGDHYVIDGRKWWSSGAMDPACELFIVMGKTDPGAERHRQQSMVLVPRDTPGVTVRRGMTVYGYSDGPHGGHAEIDFTGVRVPVENLIGTEGTGFAIAQARLGPGRIHHCMRLVGMAERALELLCRRVTERIAFGRPLAEQGVVREWIAESRVRIEQARLLVLKTAWLMDTVGNKGAHTEIQAIKIATPAMAEWVIDKAVQAHGAAGVSQDTPLAALWAQARTLRLADGPDEVHRASLARRELRRWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEZ3</accession>
    <name>F4FEZ3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732373.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12955"/>
    <dbReference type="EnsemblBacteria" id="AEB43705">
        <property type="protein sequence ID" value="AEB43705"/>
        <property type="gene ID" value="VAB18032_12955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12955"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007526_0_0_11"/>
    <dbReference type="OMA" id="FVDYYAE"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="50"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="363" mass="39189" checksum="35C7D3BE9C4335B4" modified="2011-06-28" version="1">MTDPATRHPTPERHRGTGGDSPAGLDLGRLSHYLAEHRPDLATAPLRAELITGGRSNLTYLLRAGGQELVLRRPPLGHVLATAHDMAREFRVISALAPTDVPVPDAVLLCSDPDVLGAPFYLMRRVPGEVFRSRQQTDGLTAEQRHGLAMAMMDTLAALHTVEPEAVGLADFGRPDGYLARQVRRWAGQLDRSRSRPMPGIDELRDLLAATAPEGRNAGRIVHGDYRLDNLLATVDPVTVAGVLDWEMATLGDPLADLGLLLTYWEVLGGRDIADGNPVADGLGPRAGFPTGTELIDRYVDRSAVDVGPLHWHIALGCFKLAVICEGIHYRYTLGQTLGEGFDTIGDMVAPLVAHGLNAVRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF36</accession>
    <name>F4FF36_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13170"/>
    <dbReference type="EnsemblBacteria" id="AEB43748">
        <property type="protein sequence ID" value="AEB43748"/>
        <property type="gene ID" value="VAB18032_13170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13170"/>
    <dbReference type="eggNOG" id="ENOG502ZQDZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_219279_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="39" mass="4034" checksum="D7FECEBAE7BC899B" modified="2011-06-28" version="1">MRIGNTEIRPAGGGLGCLLMILVSIVASIVLTVLLNLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFB0</accession>
    <name>F4FFB0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_19565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733670.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19565"/>
    <dbReference type="EnsemblBacteria" id="AEB45015">
        <property type="protein sequence ID" value="AEB45015"/>
        <property type="gene ID" value="VAB18032_19565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19565"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_3_3_11"/>
    <dbReference type="OMA" id="IGFWGIS"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="35035" checksum="4E8F6D8B845106CD" modified="2011-06-28" version="1">MTTTSLTTGPRWARLPRRHVPVLVTLALLLVMYGIGVSQYRAFSNIQVIFNVFIDNGFLLVVAVGMTFVILTGGIDLSVGSVVAMTAMVSAWLLESGLPALPVLIIALLIGPTLGFLMGCAIHFFDIQPFIVTLAGMFFARGMCTFISDSSIRITDGFWTTMAQYRIGDPRGNFVSVSVLIAFAVVLIAAYVLAYTRLGRNVYAIGGNPQSALLMGLPVGRTRIAVYTISGLCSAIGGILLSFYTLSGAPLIAVGMELDVIAAVVIGGTVLTGGSGYVFGTVLGVLVLGVIQTLITFDGSLNSWWTKIVIGGLLFAFILFQRLIGIRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFE7</accession>
    <name>F4FFE7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734901.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25755"/>
    <dbReference type="EnsemblBacteria" id="AEB46249">
        <property type="protein sequence ID" value="AEB46249"/>
        <property type="gene ID" value="VAB18032_25755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25755"/>
    <dbReference type="eggNOG" id="ENOG502ZC0N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078207_0_0_11"/>
    <dbReference type="OMA" id="YDPGRFW"/>
    <dbReference type="OrthoDB" id="1342393at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="224" mass="25217" checksum="812746157AF715AB" modified="2011-06-28" version="1">MSISLDEAVELTRTGDVWVFRGRSVPDRAIQWTTNSPVNHVGMAVVLDDMPPLMWHAELGRSLPDMWTGTHQRGVQLHDLRDAVCVWANRYGQRAWLRQLEPPADPEMERAVLRTIARLDGTPFPSTAQLAWRWLRGRVPTPQLPMPRLPMRAARQRPANSGESTLETAYCAEVVAVTYEAMGLLPAGRRPNWYDPGRFWSGDDLGLQGGARLGSEIEVRMPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFM3</accession>
    <name>F4FFM3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxynitrite isomerase</fullName>
            <ecNumber evidence="1">5.99.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ferric nitrobindin</fullName>
            <shortName evidence="1">Nb(III)</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="1">Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrobindin family.</text>
    </comment>
    <dbReference type="EC" id="5.99.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736134.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02080"/>
    <dbReference type="EnsemblBacteria" id="AEB47500">
        <property type="protein sequence ID" value="AEB47500"/>
        <property type="gene ID" value="VAB18032_02080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02080"/>
    <dbReference type="eggNOG" id="COG4044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085483_0_0_11"/>
    <dbReference type="OMA" id="YSQKTWK"/>
    <dbReference type="OrthoDB" id="1524197at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062213">
        <property type="term" value="F:peroxynitrite isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="2">
        <location>
            <begin position="39"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="1">
        <location>
            <begin position="47"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="197" mass="21847" checksum="06BA1AB5020C9990" modified="2011-06-28" version="1">MSDDNPLAPPPWLNAPPVDPYPYEESHDLRVGPKLHPSLDGLLPYIGVWRGRGRGGFPTIEDFDFAQEIRISHDGRPFLSYESRAWILDEQSRPVRPAGREVGWWRPVLDGDRVTDELEALLTVPTGVMELHIGRRKGTQIEFVTDAVVRTATAKEVTAGHRLFGIVEGALLYAQDMAAVGQPLSPHLSARLIRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFR0</accession>
    <name>F4FFR0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="12" type="ordered locus">VAB18032_02265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736171.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02265"/>
    <dbReference type="EnsemblBacteria" id="AEB47537">
        <property type="protein sequence ID" value="AEB47537"/>
        <property type="gene ID" value="VAB18032_02265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02265"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_11"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="540" mass="56930" checksum="443F7A63238FC2A9" modified="2011-06-28" version="1">MAKMIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPMALKRGIEAAVTSVSEELLKLAKDVETKEQIASTASISAGDNTVGEIIAEAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISAYFMTDPERMEAVFDDPYILIANSKISSVKDLLPILEKVMQSGKPLLIIAEDLEGEALATLVVNKVRGTFKSVAVKAPGFGDRRKAMLTDIAILTGGQVISEEVGLKLDAVGLDMLGRARKVVVTKDETTIVDGAGDAEQIQGRVNQIRAEIDKSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNAKAAVEEGIVPGGGVALVQAGKTAFDKLDLTGDEATGAQIVKIALDAPLRQIAVNAGLEGGVVVERVRNLDAGHGLNAATGEYVDLLAAGIIDPAKVTRSALQNASSIAALFLTTEAVVADKPEKTPAAPAGPGGGDMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG48</accession>
    <name>F4FG48_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ordered locus">VAB18032_13400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732459.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13400"/>
    <dbReference type="EnsemblBacteria" id="AEB43792">
        <property type="protein sequence ID" value="AEB43792"/>
        <property type="gene ID" value="VAB18032_13400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13400"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_11"/>
    <dbReference type="OMA" id="RGAESCY"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="27696" checksum="23FD8469AF1426D2" modified="2011-06-28" version="1">MIELKSVEEIGRMAVTGQFVGELLAELRTVAAVGVNLMDLEHHARRRIAERGAESCYWDYAPSFGRGPFRNVLCLSVNDAVLHGLPHDYVLRDGDLLSIDMAVGIDGWVADSALSFVVGTPDPADLRLIEATEVALEAAIAAAQPGGRLGDISAAIGEVAEAYGYGVNAEFGGHGIGRTMHEAPHVANDGRPRRGLKLDPGLTLAIEPWFCRSTDKIRYDSDGWTIRSADGSRTAHSEHTVAITAAGPQVLTRRPAPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGL3</accession>
    <name>F4FGL3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_26250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734999.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26250"/>
    <dbReference type="EnsemblBacteria" id="AEB46348">
        <property type="protein sequence ID" value="AEB46348"/>
        <property type="gene ID" value="VAB18032_26250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26250"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="IMMQKIM"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="25726" checksum="96EA4661962C1B29" modified="2011-06-28" version="1">MTTLLEIEDVSLLYGRIKALHGISLTVNEGEIVALIGANGAGKSTTMRAISGIRPIASGRIVFNGEDISKLRADLRVRRGLCQAPEGRGIFPGMTVMENLDMGAYTRRDRAEVAKDLAKVLDLFPRLAERRKQVGGTLSGGEQQMLAVGRALMSRPKLLLLDEPSMGLAPMLIQQIFSIITEINQQGTTILLVEQNAQQALARAHRAYVLETGRIVKEGSGADLLHDPAVKEAYLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGM3</accession>
    <name>F4FGM3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase family oxidoreductase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26300"/>
    <dbReference type="EnsemblBacteria" id="AEB46358">
        <property type="protein sequence ID" value="AEB46358"/>
        <property type="gene ID" value="VAB18032_26300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26300"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_9_0_11"/>
    <dbReference type="OMA" id="HHNMPSV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="334" mass="36115" checksum="747F60965D5A6D4D" modified="2011-06-28" version="1">MIDVPLSVLDLAPVAAGASAGEALRHTTELARRTDELGYHRFWVAEHHNMPAIASSAPAVLIAHLAAHTSRIRLGSGGVMLPNHAPLVVAEQFGTLEALHPGRIDLGIGRAPGTDQVTALALRRTMEGLSAEKFPQELAALMDFFDEDRSGRIMASPGRGQRPAVWLLGSSGFSAQLAGALGLPFSFAHHFSGQHTLPALALYRQSFRPSRWLEQPYAMVAVNAVCAETDERAEWLAGPAGLSFLRLRAGRPEPLASPEEAAAYPYTDLEREFVAQRREGQATGSPETVARQLGDLLARTGADELMLTTMVYDIDDRVRSFELIAERVAGGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGQ7</accession>
    <name>F4FGQ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_02415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736200.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02415"/>
    <dbReference type="EnsemblBacteria" id="AEB47567">
        <property type="protein sequence ID" value="AEB47567"/>
        <property type="gene ID" value="VAB18032_02415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02415"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_11"/>
    <dbReference type="OMA" id="RDRHLPH"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="410" mass="41266" checksum="0E4EE2BCAA7B748F" modified="2011-06-28" version="1">MNQLARRLGVPDAVVIGLGSMLGAGIFVVFAPAAAAAGGIGLLTALVLAGFIAYCNATSSARLAARYPESGGTYVYGRERLGPYAGFVAGWGFVVGKTASCAAMALTIGAYLWPGQARLVAVAAVVAVTAVNLRGIAKTATATRILVLVVLAVLALVAVAGATDVSIARIDAPGGSARGVLTAAGLLFFAFAGYARIATLGEEVREPERTIPRAVPLALGLVLVIYLALAVIALGVLGPARLAASGAPLADVVTAAGLPGLAWVVRAGATVAVTGVLLSLVAGVGRTTLAMARRRDLPAALAAVHPVHQVPHRAELAVAAVVILVVMLADVRNAIGFSSVTVLVYYAITNAAALTLGRDRDRTLPVQALAGTGLVGCILLAVNLPLGSVLAGFGVLALGSAWYALRPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGR7</accession>
    <name>F4FGR7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736210.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02465"/>
    <dbReference type="EnsemblBacteria" id="AEB47577">
        <property type="protein sequence ID" value="AEB47577"/>
        <property type="gene ID" value="VAB18032_02465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02465"/>
    <dbReference type="eggNOG" id="COG2852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052626_5_2_11"/>
    <dbReference type="OMA" id="WTDIRVT"/>
    <dbReference type="OrthoDB" id="1483891at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="35598" checksum="8882BCB260132FB2" modified="2011-06-28" version="1">MPPSPYRPAALAWQVFRGSEAIRDRLITRHQLRGASWVRLMHDVYADARLDRDHELLCRAASLRLPPGVLMAGPSAAYLHGIEHAATFTDEVHVLAPMQFRLGSQRGIRVHTLGPRQPPQPTPAPTPASAEHACRPVAVAGPVGSQPLLRSDVICAAWECAVWLEPVQAVGIIDAMLRQKLVDHTRLDAMARANAGRPGGRRAEWVFGLADAGAQSPPESQLRVRLILAGLPRPVTQHPVRLASGRILHPDLCWPEYRVAVEYDGLWHSDPDQLHLDRQRLNQLVAAGWRVLHVTSRRLHHDFPGLVREIRTALAAAGWHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGY4</accession>
    <name>F4FGY4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731271.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07380"/>
    <dbReference type="EnsemblBacteria" id="AEB42598">
        <property type="protein sequence ID" value="AEB42598"/>
        <property type="gene ID" value="VAB18032_07380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07380"/>
    <dbReference type="eggNOG" id="ENOG5032KR3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2398773_0_0_11"/>
    <dbReference type="OMA" id="MNARTRW"/>
    <dbReference type="OrthoDB" id="2175209at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="93" mass="10090" checksum="A40BA7D74D277D37" modified="2011-06-28" version="1">MNARTRWQLAVPLIGLSLLMIVPAVGGTWVFWSEFGPTYRALSVVICLVLLAQLGLAVSIGVRPTRDVPWLRIGLIAVTFLVACCVAAVRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH96</accession>
    <name>F4FH96_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13810"/>
    <dbReference type="EnsemblBacteria" id="AEB43874">
        <property type="protein sequence ID" value="AEB43874"/>
        <property type="gene ID" value="VAB18032_13810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13810"/>
    <dbReference type="HOGENOM" id="CLU_2025760_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307900" evidence="2">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="122" mass="11611" checksum="BC608B0733EFA878" modified="2011-06-28" version="1">MARLLTGFAVAAAFAVGAWTMPAPAAHPGDLGPAAGPAGQPSMVSFAPPTEALASDRCAAIPPTADGLASGDDDRPGAGAATAPVPSARTDQGVDLAGAAADDQPPAVDTSGLRCGRAPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHC2</accession>
    <name>F4FHC2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_13940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732567.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13940"/>
    <dbReference type="EnsemblBacteria" id="AEB43900">
        <property type="protein sequence ID" value="AEB43900"/>
        <property type="gene ID" value="VAB18032_13940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13940"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_11"/>
    <dbReference type="OMA" id="TREYPPD"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="204"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="407" mass="43186" checksum="06A34F2DE55AB64C" modified="2011-06-28" version="1">MTDSTGLRVDLLTREYPPEVYGGAGVHVEYLARELRRLAEVRVHCFGAPRSEPGVRAYPDPPGLAGANPALRTMGVDLEMAAGCAGADVVHSHTWYANLAGHTAKLLYGVPHVVTAHSLEPLRPWKAEQLGGGYALSSWCERTAYESADAIVAVSAGMRRDVLTAYPSVDPDRVHVIYNGIDTAQYAPDPGTDVLARLGIDPALPSVVYVGRITRQKGLPHLLRAARALPPEAQLVLLAGAPDTPEIAAEVEGLVAELRASRSGVIWVAEMLPKPEVIQVLTHATIFVCPSVYEPMGIVNLEAMACETAVVATATGGIPEVVADGETGLLVPIEQAGLDGTPADPARFEADLAARLNELLASPDRAAALGRAGRRRAVEHFSWDAIAARTLALYEQVRKGPLPTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHC5</accession>
    <name>F4FHC5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide biosynthesis protein CapD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732570.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13955"/>
    <dbReference type="EnsemblBacteria" id="AEB43903">
        <property type="protein sequence ID" value="AEB43903"/>
        <property type="gene ID" value="VAB18032_13955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13955"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_1_11"/>
    <dbReference type="OMA" id="IIIAMPS"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="301"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="625" mass="67374" checksum="C5E5E085B00893C3" modified="2011-06-28" version="1">MPPETERVQPTSSTTTGRIRANSRRTAVFLVADALAWVGGFTVAGWARYEQSLTIDQAVNAVILGSAAAMLHVGVSAMRRVYSGRQPLGSIEEVRGLAGTTAATATVVLVALLTISERPVPASTPVVGGALALLLMLSFRLLHRHRRDRAMRPDARSATPVLLFGLGEAGQGLVRAMLGDPKGRYLPVGALDDDPDKQDLRIAGVPVLGGRAEIAEAIRRTGATALIFSVANADATLIRGVREATLRTGAAFKILPPVRELVDHRITVRDVRDVQISDLLGRRQVTGELTLDDNVLTGRRVLVTGAGGSIGSELCRQIMRANPGELMMLDRDESALHSLQMSLTGRALLDGPELILADLRDDEGIRRIMQERRPEIVFHAAALKHLTLLERHPGEAVKTNVWGTLTVLDACRDVARFVNISTDKAADPISVLGYSKRITEMLTAHAAATYPGTFLSVRFGNVLSSRGSVVTAFQRQIEAGQPLTVTHPDVTRYLMTVQEAVHLVLQAANIGRDGEALVLDMGEPVRIDDIARRMVEQAASTVEIVYTGLRPGEKLHEDLLGSGESDHRPLHPLISHVRVPVLDPLEASGLDPFDEPDKVIDQLARLCGVLPGALLNQKTGIPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHH4</accession>
    <name>F4FHH4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733801.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20230"/>
    <dbReference type="EnsemblBacteria" id="AEB45146">
        <property type="protein sequence ID" value="AEB45146"/>
        <property type="gene ID" value="VAB18032_20230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20230"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OMA" id="FHIDAEI"/>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="268" mass="28860" checksum="6880A559E8E021F3" modified="2011-06-28" version="1">MPTSRLGGSGLRLAYERRVVADDLTVAVPDRSFTVIIGPNACGKSTLLRALSRLLKPAVGAVLLDGEDIQRRPARAVARTLGLLPQSPIAPDGIGVADLVARGRYPHQGLLRQWSRDDERIVAEAMAATGVADLADRLVDELSGGQRQRVWLAMALAQQTPLLLLDEPTTYLDIAHQIEVLDLCARLHEEQGRTLVAVLHDLNHAARYATHLIAMRDGRVVAAGEPGQIVTAELVEEVFGLPCRVIDDPETGTPLVIPAARIRTGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHZ2</accession>
    <name>F4FHZ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03005"/>
    <dbReference type="EnsemblBacteria" id="AEB47685">
        <property type="protein sequence ID" value="AEB47685"/>
        <property type="gene ID" value="VAB18032_03005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03005"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_2_0_11"/>
    <dbReference type="OMA" id="EFYLAHR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="BLACT_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="292" mass="29982" checksum="6C9F4BABC6CC3052" modified="2011-06-28" version="1">MTALASELPEWVTLLRAPNPGVMTLDGTNTWLLRAPGAAYGVLVDPGPADEGHLAAIAALGPIGLVLITHGHPDHTEGSPRLHELLDGVPVRAVDPAYSIAAPPLAGVEPAGGGLTGGGLTGDEPAGDEPAGVELGGDGCGLSIRLVPTPGHTTDSICLLVEREGRQVVLTGDTILGRGTTVVAHPDGHLGDYLASLELLSTYRGIPALPGHGPALADCGAAAEFYLAHRRARLDQVRAALDEGAQTAAEVVAKVYADVDRSLWWAAEWSVRAQLEYLGRDTGADGVGLDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F123</accession>
    <name>F4F123_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07785"/>
    <dbReference type="EnsemblBacteria" id="AEB42677">
        <property type="protein sequence ID" value="AEB42677"/>
        <property type="gene ID" value="VAB18032_07785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07785"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057862_1_0_11"/>
    <dbReference type="OMA" id="ALDYIGM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="34205" checksum="A6B079CE4D5F0B6D" modified="2011-06-28" version="1">MSSVHPYARELGDFLRARRGRLRPRDVGLEPGGRRKVTGLRREELALLAGLSTDYYQRIEQGREVRPSDDVLDALAGALSLDDKERRHLFTLAHAARRSAPAPVNRDPERVPDSTRRLLRVMDTPAVILSRHLDLLDWNPMAQALLGDPDAYPTDRLNMLLLLFDDTLTGERSCPDWEQQALDYIGMMRAAVATDPTHPRATAIVGELSIRSDQFRRLWAQHDVRDSVSGTKTFRVPEVGDIALDWDTYPLPGNPGSVMLVFTAEPGSADADRLQLLASLHATRSALGNKHPSQTRGTAARRTPSGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F170</accession>
    <name>F4F170_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trka-n domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731397.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08030"/>
    <dbReference type="EnsemblBacteria" id="AEB42724">
        <property type="protein sequence ID" value="AEB42724"/>
        <property type="gene ID" value="VAB18032_08030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08030"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055253_1_0_11"/>
    <dbReference type="OMA" id="HIIVCGC"/>
    <dbReference type="OrthoDB" id="599322at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="123"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="36089" checksum="D38C01D63FEA30B3" modified="2011-06-28" version="1">MIHFPAQRRGPLSALSLRLAAAVGLVLIVVAAVYLERDQYRDINDDGLTLLDCFYYAVVSLSTTGYGDIVPASQSARLVNVLLITPARVLFLIILVGTTLEVLTEQYRTGRRLHRWERKLKDHVIICGYGTKGRSAISALQENGLDKSRIVVVERSGAALRQATSNGLVAIEGSATRSSVLNQAHVRTAKAVIIATDSDDASVLVALTVRQLTAGQVRIIAAAREAENAPLLKQSGAHHVIVSSATAGRLLGLSTSAPPLIDVVEDLLTPGQGMALAMRSAERHEVGRNPRELESLVIALVRRGKVVTLADQAGAVVETGDMLVHVRDDRPTANTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1B8</accession>
    <name>F4F1B8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732621.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14210"/>
    <dbReference type="EnsemblBacteria" id="AEB43954">
        <property type="protein sequence ID" value="AEB43954"/>
        <property type="gene ID" value="VAB18032_14210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14210"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_11"/>
    <dbReference type="OMA" id="QFHVWED"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="36860" checksum="3409F2661F4FB8CA" modified="2011-06-28" version="1">MQYRRFGRLGWSVSDVGYGMWGIAGGEGGWSGADDATGHAALDAAVEGGCNFFDTAWIYGRGHSEVLLGELLRRHPDRRLYVATKIPPKDRNWPSTRESRLEDVFPADHVREYLHKSLENLGVERIDLLQFHVWEDSWAEDPRWQDMVRELRESGLVTGIGLSLNRWEPWNGMAAMRTGLVDAVQVIYNIFDQAPEDELFGLCQELDVAVIARVPFDEGTLTGTLTMESTWPEGDWRNSYFVPENLAASVARAEALAKDVPDGMTMPELALRFILAHPTVSTVIPGMRKIHHVQANLATSDAPPLEESVLARLREHRWDRQPTAWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1R6</accession>
    <name>F4F1R6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27091"/>
    <dbReference type="EnsemblBacteria" id="AEB46491">
        <property type="protein sequence ID" value="AEB46491"/>
        <property type="gene ID" value="VAB18032_27091"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27091"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051715_2_0_11"/>
    <dbReference type="OMA" id="WAFAEHW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="277" mass="29797" checksum="803CA6421463C736" modified="2011-06-28" version="1">MTQVSERPRIVRGWEWARPVRPVRREVLSAAPELEEGQPPLLFVPGFGHGAWAFAEHWLGHTASRGFPAYAVSLRGHGGSGPAPEADLRAYAHDVVQAAAGLPRQAVLVGHGAGALVVAHALARYPARAAVLVAPVFGGWAGLGAALRRNPVGTLPAVFGGGLRPRRSQLFSRELPEAEARRYTARLGRAARRAQWQLLTGADPEPPVGRPPVLVLGSPDDRVVPATALTRAARRYGSAPLLFPGMGHDLMLDARWQEPIDAILDWLRKHPGRTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1X6</accession>
    <name>F4F1X6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736355.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03195"/>
    <dbReference type="EnsemblBacteria" id="AEB47723">
        <property type="protein sequence ID" value="AEB47723"/>
        <property type="gene ID" value="VAB18032_03195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03195"/>
    <dbReference type="eggNOG" id="COG2356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043034_3_1_11"/>
    <dbReference type="OMA" id="RWESVYD"/>
    <dbReference type="OrthoDB" id="1510738at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309012" description="DUF1524 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="114"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="24152" checksum="798F9F8E5B612CA2" modified="2011-06-28" version="1">MRTRSGPRALGALALVAALTLGAAGCVPLDEVPDTSSSSGGGTANQMLSELTVAEANPMRGYSRKRFPHWRKTGQNCDVRDTVLERDGKGIQRSGCNVVGGQWESVYDGRSFTDPLQVDIDHMVPLANAWRSGADEWDDTKRGDFANDLDRPQLFAVSASSNRAKGDQDPSQWKPPSQSYWCQYAHDWVAVKHHWQLTVTSAEKAALTDMLEGCTWESKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4F222</accession>
    <name>F4F222_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03425"/>
    <dbReference type="EnsemblBacteria" id="AEB47769">
        <property type="protein sequence ID" value="AEB47769"/>
        <property type="gene ID" value="VAB18032_03425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03425"/>
    <dbReference type="HOGENOM" id="CLU_3067418_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309015" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="53" mass="5371" checksum="05D5181617204B4B" modified="2011-06-28" version="1">MRNLPAFVAVGVLGVVLGMLGSVGLANVLSPSAKEAANSKVSEQTEAPLYGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F283</accession>
    <name>F4F283_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_08270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08270"/>
    <dbReference type="EnsemblBacteria" id="AEB42772">
        <property type="protein sequence ID" value="AEB42772"/>
        <property type="gene ID" value="VAB18032_08270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08270"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021525_0_0_11"/>
    <dbReference type="OMA" id="PLGGPEC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="247"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="518"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="714" mass="73731" checksum="5DEE58540C99957D" modified="2011-06-28" version="1">MAFGPILFGAVFVASTVTAVDRSRATERLAVAAAAARTSIDALCQQLRAAADAVALTADHRGAATQVVGRGLAAAVQVTDVTGQIVVATPNAPPAPWRDCGDHARPTGPVAALAVRVELHDIGGAVLGTVTAAQPVDPMLVARLAAVTGVAVTLLDGAAPTLTVAHSTESDGGAEAVLAAASALHEEGVTSTPDGRYLRRVGPTPGQPLPLVLSVPSDQPAGLYPVLIAVVLLAALLGVAVAWRLARVTTRPLVELAGAVDRVAAGDLTARVPVRSGDEIGRLAEAFNRMTREAGGYLAALASSRDQLRGHLAVLGDTLASTHDLQRILRVILHSALAATGARAGAVLLTEPGGMLVAQCTEGLDEHWAGTGTPQVPLGGSVVGAVAATGQPCRGRMEAAAPGEPRCGTYIAVPFAAPEAGRTADSRAGEEPAHAAASARPLGVLALYDRLGGEEFDDDDLATLQTFAGHVAVAVDNVRVHEEAQRLSLTDPLTGLWNYRYLRESLRREVERANRFGRMVSVLVLDLDRFKKINDTYGHAAGDTVLAEFARRVRGEIREVDLAFRQGGEEFVVLLPETDARGATIVAERLGAATRNTPVTVLGHAGVQESIGFTVSIGIAVYPDHAETGLRVLEAADEALYAAKAAGRDTWRVAQDTSRITDPGDGGTGVRAAHAAPPTREMSVSAVTSSPIDGLPRAGPVDATGALAERDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2K9</accession>
    <name>F4F2K9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733928.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20870"/>
    <dbReference type="EnsemblBacteria" id="AEB45274">
        <property type="protein sequence ID" value="AEB45274"/>
        <property type="gene ID" value="VAB18032_20870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20870"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050554_1_1_11"/>
    <dbReference type="OMA" id="EVQDVWT"/>
    <dbReference type="OrthoDB" id="1650048at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="215" mass="23502" checksum="4ACA2F09466157AB" modified="2011-06-28" version="1">MGDQRAVARALLTRHTYAEEAGISLADRPAPLYQLLVLVTLLSTRIRAQVAVAAARELFAAGYRTAAAMEAASWQQRVDALGRGHYRRYDERTATMLGTGARLCLDRWHGDLRRLRRQADGDQDQLRRLLVEFPGIGPTGADIFLREVQTVWPELRPYADRRAVAGAKRLGLPAATDRLAGLVDEGEFGRLASALVRVALGEESAGQITRSVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2N3</accession>
    <name>F4F2N3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733952.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20990"/>
    <dbReference type="EnsemblBacteria" id="AEB45298">
        <property type="protein sequence ID" value="AEB45298"/>
        <property type="gene ID" value="VAB18032_20990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20990"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_11"/>
    <dbReference type="OMA" id="PNFIFTF"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="494" mass="55170" checksum="55F07D169FFF651E" modified="2011-06-28" version="1">MAPDHVDVLIVGAGLSGIGAACQLRRHCPDKTFAVLEARDCIGGTWDLFRYPGVRSDSDMSTFGYSFAPWQAPKVIAEGATILDYLRRTADEHDVTRHVRLRHRVLRADWDSRQARWTVLVRRDDTAETLTLTCSFLYACTGYYRYDAGYAPQFTGQEQFTGRIVHPQHWPADLDLRDRRVVVIGSGATAITLVPALARQAAEVTMLQRSPTYVLAHSSDDALADTLRRRLPERLAYPLIRWKSILLVTAIYQLSRWAPGLVRRALRRRTARALPAGYDVDRHFNPRYDPWDQRLCVDPDGDLFAAVSAGRATVVTDTIDRFTTDGIALNSGVHLPADVVVTATGLDLLLLGGMTLRVDGVDVDVAQTVAYKGTLLSGVPNFALAFGYTNASWTLRTDLVAEYVCRLLRHLDRTGTQVVTPLAPPDDRRAPLVGLTSGYVRRGVDRLPRQGHRAPWRVRQNYLRDLLLLRFGRVTDPGVRFSRADSALRRSVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2V8</accession>
    <name>F4F2V8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27481"/>
    <dbReference type="EnsemblBacteria" id="AEB46569">
        <property type="protein sequence ID" value="AEB46569"/>
        <property type="gene ID" value="VAB18032_27481"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27481"/>
    <dbReference type="eggNOG" id="ENOG502Z9GU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023913_1_0_11"/>
    <dbReference type="OMA" id="GGMHNDG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="538" mass="54546" checksum="07D968FDE7BF643E" modified="2011-06-28" version="1">MTEPGAPHPDPASTTEAGSTTGREGGSTADREAGSVTGRDRVARWIGLAGAVLLATASFLGGALPERTTNPAVDGPLTVILWLAGTTAMVGAWWALRGGAPSAAWAYRTAGLWALPLLFSAPLGSRDVYSYACQGWVYADGGDPYATGVAAAGCPWLDAVAPVWRDTAAPYGPFFVLLGALAVVLGSGLVGTVALLRVLAVAGLLVAALCLPGLARAAGVPTRRAIWLVLACPLVGVHLVAGAHNDAVMLGLLLPGLLLLVRPPGRLLSGRKGVPAVAGLLAAGVLLGLAVSVKATAVVVLPFAALAAVRGRHTVAALLRDGGLLAVGVVGALVVTSLLSGLGLGWIGGLGSSGDTVQWTSPPTAVGMVVDYVGRLVGRPPGAVPVTRVVGLVVLAAFLVLLWCRTWSALRTPAARSDGAGGWVIRLAARAGVVRPADPRTPPGERRLILGAAGMALVATVVLAPVFHPWYATWPLALLAVTATRTAWFALPCAAASFLALPDGSNVARLVKAPGAVAMTLLVLAVVLRAPSWLRRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F351</accession>
    <name>F4F351_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03740"/>
    <dbReference type="EnsemblBacteria" id="AEB47830">
        <property type="protein sequence ID" value="AEB47830"/>
        <property type="gene ID" value="VAB18032_03740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03740"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016537_0_0_11"/>
    <dbReference type="OMA" id="PLIIWRT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="492" mass="53584" checksum="5AFC0B6BE6FF6E2B" modified="2011-06-28" version="1">MTPVTLLFGTRTAFLVFLTLGMIATATAWYFVLSRVLVGARGPAWLGATFCAYAPAMISHANAHPNIVSQYVVPLIIWRTVRLADGGRWLRNGLLLALVIVWQAFLNLEILLMTAIGLGVVIVALALARPALRGRARTFLAGLGIAAAASVVLLAYPLYVQFFGPGAYNGLSWVIRGYSTDLASFVAYARESLAGDARSATGLAKNPTEENSFFGWPLVILMAAVVWWLRRNVVVLALAALGVLFAVLSLGREIRFDREGTGIPAPWALLEDLPVLHSVVPTRWALAITPIIGLLLAYAAERARELAARYPARRSQIRFGTVTVLAMALVPVLPTPLPTKRLDPTPEFVTSGAWRPYLAGGRSLVTLPLPDTEYADPLRWSAQTRLEMPIARGYFLGPDTRPGKDRIALFGAPPRPTSSFVATVRRSGEVPPVTAENRREAVEDLRYWRAGAVVLAPQERADALRQAMTELTGIEPVHTGGVWVWDVRPLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F376</accession>
    <name>F4F376_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736487.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03865"/>
    <dbReference type="EnsemblBacteria" id="AEB47855">
        <property type="protein sequence ID" value="AEB47855"/>
        <property type="gene ID" value="VAB18032_03865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03865"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_1_11"/>
    <dbReference type="OMA" id="DLETCFK"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="232" mass="26002" checksum="281AD7C165D8D498" modified="2011-06-28" version="1">MKLSILMPVYNEEERIGDALKQALAVEYPCEIELVVVDDGSRDGTGEVLGRADDARLRVITHQRNAGKGAAIRTAVAAAEGEYMVILDADLEYDPQDIPKLLAPVLDGRATVVYGNRTFGSHSAYSFWYVMGNRGVTMAANVLFNSYIGDLETCFKLMPVALYRSLDIRSRGFGMEAEVTGKLLRRRIRPYEVPISYRARGREEGKKITWRDGVEALWILGRERTRRRPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Q2</accession>
    <name>F4F3Q2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734007.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21265"/>
    <dbReference type="EnsemblBacteria" id="AEB45353">
        <property type="protein sequence ID" value="AEB45353"/>
        <property type="gene ID" value="VAB18032_21265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21265"/>
    <dbReference type="eggNOG" id="ENOG5031VIC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1675879_0_0_11"/>
    <dbReference type="OMA" id="FINADSS"/>
    <dbReference type="OrthoDB" id="2201648at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="162" mass="17750" checksum="3E61AE2E3CC612B8" modified="2011-06-28" version="1">MSVQEQIFINADSSPEEVAEQLAAALSMRKFAGRKGGVYVSRPARWGVAGGKEVGGEVADNYLADAQASQAEQSLLDGYQILWDFGYTGRDRDIQLAEARLAFTELAASVLWPAALIAGLDTLIAAWDPVLGLTWFPPGTTPDADSRELWYRYFERLAQPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Z2</accession>
    <name>F4F3Z2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_27826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735288.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27826"/>
    <dbReference type="EnsemblBacteria" id="AEB46638">
        <property type="protein sequence ID" value="AEB46638"/>
        <property type="gene ID" value="VAB18032_27826"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27826"/>
    <dbReference type="eggNOG" id="COG3973">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010312_3_1_11"/>
    <dbReference type="OMA" id="WWPELTP"/>
    <dbReference type="OrthoDB" id="114076at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="181"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="202"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="704" mass="77334" checksum="8D5BB2224EF0B277" modified="2011-06-28" version="1">MDQSTLDQEIAVEQRHLDRVYARLAELRRGAVRAERDGYRLARVGNFGALVERDAMVFHAAQRRHLFDAEYEGLVFGRLDLRDGQVIYVGRLGIRDEDASTLVVDWRAPAAAAFYQATPAEPLGVVRRRTIQSSGERVTRIEDDLLDPEAAPPDMPVVGDGALLATLSRTTGRGMRDIVATIQREQDEAIRSPSSGVTLVSGGPGTGKTAVALHRAAYLLYADRSRYAGGGILVVGPSSVFVSYIASVLPSLGEDNATLQSLGSIFPGLVATRTDPPRVAAIKGSLRMRRVLERAVRDTAPGAPTELRLLYRGQLLRLERAELNTVWNRALPRGARRNEVRRAGFDGVLAALWAQARRLGIAGLPEQRAFEDELIDRSDFREFLKAWWPRLHPRHVLGWLADHERLRRYAGGILSGAEIRLLGEAYRGLATDGPTVADTALLDELDTLLGKPVRPARAKRDPFQLAGGVRELSTFADRQRAARQAARERPEDYRDYAHVVVDESQDVSPMQWRMIGRRGRLASWTVVGDPAQTAWTGDPQELNRAREQALGRRPRHRFTLTTNYRNSAEIFAVAAEEIRRVYPDLPLPTAVRSTGVDPVQLVVPAAELTTSVVSAAGTLLGEVEGTVGVITPVPWRDEVAGWLDGLGGDRLQVVTSLEAKGMEYDAVVLVAPSEIRAVPDSGVRTLYVALSRATQRLTTVDVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F423</accession>
    <name>F4F423_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27981"/>
    <dbReference type="EnsemblBacteria" id="AEB46669">
        <property type="protein sequence ID" value="AEB46669"/>
        <property type="gene ID" value="VAB18032_27981"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27981"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130902_1_0_11"/>
    <dbReference type="OMA" id="FAEIKEH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="123" mass="13438" checksum="2C22A347D154DBD0" modified="2011-06-28" version="1">MKYLMLIYGNEQIWGSLPAGDLATLIGEVDAFNEELRARGELVDVQGLDAPARSVRMAGDTPVVTDGPYLEAKEYVGSYFVVDVDSEQRALEIARSYPGLRFAPGVGGGIEMWPLMIRDGVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F428</accession>
    <name>F4F428_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735324.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46674">
        <property type="protein sequence ID" value="AEB46674"/>
        <property type="gene ID" value="VAB18032_28006"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28006"/>
    <dbReference type="eggNOG" id="ENOG502ZECH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1401925_0_0_11"/>
    <dbReference type="OrthoDB" id="2184157at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312673" evidence="2">
        <location>
            <begin position="24"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="20326" checksum="3922E9E8EA2E8813" modified="2011-06-28" version="1">MPTSRILSWPLACCLLLASAACTAEETGQEEPRPPVPATSLAAPDTTGSSQAGDGVVSCSSAVDKLREPPDGYRIVGADVAVPDREVIEAQESEKPDPAARLFAKWGLVVRVGAVVDLRVGPGWEDRARVGWGRPAVPAVSVQVQACAPDDDQAQWLAFVGGTWVAQPTCLPLTIRSQGRTSQVRLGIGVACDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F438</accession>
    <name>F4F438_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_28056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735334.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28056"/>
    <dbReference type="EnsemblBacteria" id="AEB46684">
        <property type="protein sequence ID" value="AEB46684"/>
        <property type="gene ID" value="VAB18032_28056"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28056"/>
    <dbReference type="eggNOG" id="COG3828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032985_0_0_11"/>
    <dbReference type="OMA" id="KADCRPE"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307657" evidence="2">
        <location>
            <begin position="31"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="447"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="568"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="702" mass="73397" checksum="15140A1AC1E3C715" modified="2011-06-28" version="1">MRRLLRPVLGVATAALAVLACTAPATPASAADTPYDVLVFSKTAGFRHDSIAVGTQTIRDLGAANSFTVTATEDAGVFTTGNLAQYEAVVFLNTTGDVLNASQQTAFESYIGSGGGYVGVHAAADTEYGWSFYGNLVGAYFRSHPAIAQATVRVENRAHAATAHLPQNWTRTDEWYDFQANPRPGARILANLDESSYSGGVMGADHPIAWCKTYAGGRSFYTGAGHTQASYSEPAFRAHLLGGIRYAAGRTKADCRAETGYTTLYNGSTTGWSQAGPGSFTNSDATLSSTGGMGLYWYSAKQFTNYSLKLDWRIAGDDNSGVFIGFPPSSDPNSAINNGYEVQIDPTDTADRTTGAVYGFKSADLAARDAALNPAGEWNTYELLVEGERLQVFLNGVKINDFTNTDPVRSLAGHIGIQNHGTGDDVSFRNIRIKELGSTNPPPGSNTTVQAEAYNSANGVTVVGKTGANGGQVLGYIDPGDWAAYNNLDLTGVTSLRARIASAGPGGTIQVRTGSTTGTVLGSVSAPNTGNWNTFVDVSAPLSNVPSGTRNVYLTFTGSGGSLFDVDDFTLVRGGGGTGPITGLGGKCLDVRNGSSADGTQIQILTCNGSAAQTWTVTPNSTIRALGKCLDVNGGASADGTKIQLWTCNGGGAQNWSAQSNGTLRNPQTGKCLDVSNNSSADGQAVHLWTCHTNANQRWILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4E2</accession>
    <name>F4F4E2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08910"/>
    <dbReference type="EnsemblBacteria" id="AEB42900">
        <property type="protein sequence ID" value="AEB42900"/>
        <property type="gene ID" value="VAB18032_08910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08910"/>
    <dbReference type="HOGENOM" id="CLU_2921495_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="6149" checksum="A94E62056095C107" modified="2011-06-28" version="1">MVLGNVVLLVAAAGVAVLATLLSLVTLAGAALAGWHLTRRGSVTRRGGMSVPVALASRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4E9</accession>
    <name>F4F4E9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin/acetyl-CoA-carboxylase ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731578.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08945"/>
    <dbReference type="EnsemblBacteria" id="AEB42907">
        <property type="protein sequence ID" value="AEB42907"/>
        <property type="gene ID" value="VAB18032_08945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08945"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_5_0_11"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="30952" checksum="A31B7542D5B6C25B" modified="2011-06-28" version="1">MPGSPYTDLDRPPLSAARLRRALVAPYGPWARLELRAETGSTNADVAEAARDGEPEGLVVVAERQTAGRGRRGRTWQSPPRAGIATSVLLRPGEAVPDRDWQPAPPSGYGWLPLLAGVALVEAVGRLAELDASLKWPNDLLIDGAKCAGILAEAVPGPEFGDPPAVVLGIGLNVTLRADELPENPTGLRATSLQLAGATATDRDPLLRALLRSLADWYARWRAAGGDATASGLREAYLKVCATVGREVRALLPDGTELTGTATTITGEGHLLLTTPHPTPTTHSLPAADLLHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4P3</accession>
    <name>F4F4P3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732850.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15365"/>
    <dbReference type="EnsemblBacteria" id="AEB44185">
        <property type="protein sequence ID" value="AEB44185"/>
        <property type="gene ID" value="VAB18032_15365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15365"/>
    <dbReference type="eggNOG" id="ENOG5030F1S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177818_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="71" mass="7396" checksum="F60E88605BFD5BBE" modified="2011-06-28" version="1">MSAPGPLPGPRPGPPPRRFSAEDTDDVEHPAVQAAVQAMANAAALAPADQIAQYEAAYQTLRETLATIDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4R4</accession>
    <name>F4F4R4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_15470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732871.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15470"/>
    <dbReference type="EnsemblBacteria" id="AEB44206">
        <property type="protein sequence ID" value="AEB44206"/>
        <property type="gene ID" value="VAB18032_15470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15470"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_4_0_11"/>
    <dbReference type="OMA" id="WTVRRQT"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="191"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="401" mass="44340" checksum="FC5F9865D3B3948E" modified="2011-06-28" version="1">MASPQQPPIGVRLATDVEHRPGRDRPYRARVRWTDPTSKRRMSKSTTVATPEEAQAWIDGMASAAQGGVDPVAATKRLAEYGESVMTLALRGLERKTLDPYLAGWRKRVVPTLGHIPVRMITNGAVDRAVHSWIADEYSRSTVKNSLAVLVRVMEQAVRDGIIQRNPAQVTGWQREYQRAADELDDPRSLALPDWETLTKLAAALVDRSANHFTGWADVVIFAACTAARIGEVSGVRAEDIDRETWMWTVRRQTTPSPGGLIDKGTKGKRARTVPLIEEVRPIVAHRLDAVTKPDSRLFTGPRGGRISTAVLRDATHWDEVVTTLGFEHLRRHDLRHTGLTWMADAGVPVHVLRKIAGHGSLTTTQRYLHPDRQSITDAGTALSAHLKARRSPGGPQLRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4R7</accession>
    <name>F4F4R7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional DNA primase/polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15485"/>
    <dbReference type="EnsemblBacteria" id="AEB44209">
        <property type="protein sequence ID" value="AEB44209"/>
        <property type="gene ID" value="VAB18032_15485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15485"/>
    <dbReference type="eggNOG" id="COG3598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915119_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="11"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="32005" checksum="94595E274590F254" modified="2011-06-28" version="1">MPDLSALLTAALDYVARGWPVFMLGRTKRPVANCPDCATTTAGHDREACPCLTCHGFYAATTDPDRAAAIVRAVPTGQLALRTGAASGVVVVDVDPAHGGRDSMNALIADGLLPPTAYVVTGSGGLHLYYRHPGQPVPCSQGKPGQGLGPGIDVKADGGYVVLPPSVHPRTGRAYRWAPDRAMEEMPPRWSPPADRPRRHHRWPRPCRPPPARRGASPSPTGSWPRTCKRSPTHRKAPAAPPSTARRAASRAWSPSGPSTRPTPSPFSPTPGVAPSRPTATSAPPSEAASAPKDSPHDPPTDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4V5</accession>
    <name>F4F4V5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734097.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21720"/>
    <dbReference type="EnsemblBacteria" id="AEB45444">
        <property type="protein sequence ID" value="AEB45444"/>
        <property type="gene ID" value="VAB18032_21720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21720"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242886_0_0_11"/>
    <dbReference type="OMA" id="FHYDRPN"/>
    <dbReference type="OrthoDB" id="1356359at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1659" mass="174833" checksum="72A68F4CFD76EF1E" modified="2011-06-28" version="1">MPDITTVPTGTPIALLPYRIETRYLPRSGGQPGADLLVRVYPDQIHFDSHEPGLTPVETQARKEFLAAGGRDPDPDAPDVVSAWARLVEQFGETRAAWLARRPTDGEPLGDRPAMWSQPVRARALPDRFVVLGYRAGQLVFQRETAPIPRDLAVSPPPGEAVTPAPPPAPDASGHRPDPLDAPPGMTWMIDPAEGEANGMLLRVPLSPTQLVLDRLVVLGVRVEARPGDPDGTAGVRGAADLAALLTSHRYTDGLALVAQGTPTNNTERGPSGLDEAGLAATTSRRELLPDAADDGSDGARLAAALGVPRKVFGRVEGAEGRESRDAQAMNAALWPATWGYLLERFLTTVGPTRLEPYRRHFVDWVRARGPLATLRIGNQPYGVLPVVSLDRYQADPTDPTGARVADLVRRLRPTWLTALTTSRPETKPVLEILKRRPVSDGYAMRGVFGAHEWFDRALGFEGGPEGLDRSQLAGRVVGAQLMHQRISAALGVPPFTAFDAVKAFTGATLHDGHLPTVAADLTAPTVPWLAALRARMLATLPADVEAGGWPGKPADSVLYLLLRHAARLVATGPAPDVRGYPTRGHFGDPAAEPPPLNRYEELLAALDDLATRPARVVDLATRESLDLAGFRFDAWATSVATRRLARLRADPHAGLALGGYGFVENLTPGSQDLAVPADQIPPGEAPGLLRRASDAGYLHAPSVAQAATAAVLRAGHLNHAEEAGATGTSPFALDLSSRRVRLGTAVVDGLRQGQTLAALIGYRIERALHDTGQAAGIPALRRAVAALAGQTGEQEVVDGVALLTAHTAGQLRWGVGGLPPLAAVRPAIEVAREALDAVGDLSVAEGLHHTLQGNYQRASAALAIGKVDGVAPPELEVVRTPRTGAGITHRLLLMLDAPPPDTGPGGWQTGPRETAEPALAAWVAAVLGPAERVVADLTFVDPATGAALAPNRRVTLDDALPYPLDLLGYADDPAGIESRLAWHHLDPARRPTDVGPDATVRLLPDPAGPLSAGQVYLTDLLEVVRSIAAVLSTARPLTRTDLVAGGTAGDEDEPDGVLLEELRQRATVAHLGLTTLRAALRDAVGDIEDHGHPEGVADLSTAAAHLLTATAFGVPNVVPVARHILDATAADGGPAAEVTAAAVATLTTQVLAGYAEVRRRSMAADEIAARASRAPDWVDLLRAVFGPGFLVVPRFTPADPGQLARAFAGTSVSGAPAGQEPLAWFARTARIRPAVAAVETVCRFGQALATGWGLDLRVGQVPAPAAGEPARRWVGLPPLDPADTVPTGVTSLVAVGAGPAATGSLAGLLLDEWGEVVPARRETTAVAYHYDAPGAQAPQAVLLAVSPRPAGSSWTLDDLAATVNETIDLVKLRSVDRTDLIPEHLLSSLAYLPLWPTTAPGAVEVSRLASVPATFGVPKVAGQPRIGSVVLKGTQTALAGIRQGRTVQVIVTGENLHIPQETSTWSVDKPGLRLRVLAQSPDQTELELSAARTGTDYPAVDTYELRLVTRGGIATWLVRVTPRVTITAVTPAVVRQDQYDATVVLEVDGHLLPTVPIPHRDPPITFRVLGLDLPVTGVVPAAVPGRAAVTLRVPGRPKPPVEYNDRGKPIIKTKHWTPVPATLAVQGAWEHDEPSTEAYHELVGAFTYEVMSWTNADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F554</accession>
    <name>F4F554_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735386.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28326"/>
    <dbReference type="EnsemblBacteria" id="AEB46736">
        <property type="protein sequence ID" value="AEB46736"/>
        <property type="gene ID" value="VAB18032_28326"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28326"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151846_0_0_11"/>
    <dbReference type="OMA" id="ARNQVPE"/>
    <dbReference type="OrthoDB" id="2043951at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="125" mass="12091" checksum="1356DB8B666CE640" modified="2011-06-28" version="1">MPESPAVPAAVPAGSELSAEDGKLVILARGARGRVGAVEGAAVRDQDGRTYAAASVSLPSLTITALQLAVASAAAAGATRLEAAAVVTEASTLDGAGYAAVRDLSADAPVHVAAPDGTVLGTVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5A0</accession>
    <name>F4F5A0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_04330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736579.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04330"/>
    <dbReference type="EnsemblBacteria" id="AEB47948">
        <property type="protein sequence ID" value="AEB47948"/>
        <property type="gene ID" value="VAB18032_04330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04330"/>
    <dbReference type="eggNOG" id="COG5650">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028876_1_0_11"/>
    <dbReference type="OMA" id="RDFLIWQ"/>
    <dbReference type="OrthoDB" id="1529783at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="471"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="507" mass="55484" checksum="D3017F9E766EE31E" modified="2011-06-28" version="1">MSTKSTPGIDESGAIDHPSRSDGFVRGLSGLIGGPLGDHAVTRDRPSGGRGRFWTAVRIVLALTCLTLTLHWVQKSPCQDGAWVNNQQYTRFCYTDVLALYYAERLNEGAVPYRDHPVEYPVLTGYFMGALGLPVHSAGEGNPDINQGQWFYNLNALVLGALALATVMVLLSLRRRRPWDAAMFALSPALLLTATVNWDFLAIGLAALGLLVWARTRDDRTGLTLAILSGVLLGLGGAAKMWPLFLLGPILVLAIRANRVRAAVLSIIAAAVTVVLVNLPVAIPYRDNWNRFFELNTERPIDWGTLWYIGRYLDGKFGDPASIGPFQWLDANIPTLNYLSYALFGLACLAIGALALLAPRRPRLAQLAFLVVAAFLIFSKVWSQQFVLWMLPLVVLARPKWGAFLAWQIAEVGYFVAFYAELLGAATSTSVIPEGVFVLAASLRLATVVTLCVLVVREILHPEQDAVRRNYADDPDGGLLDGTPDAPWLDRFRNRRPAPTPTPVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5I1</accession>
    <name>F4F5I1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FO synthase</fullName>
            <ecNumber evidence="9">2.5.1.147</ecNumber>
            <ecNumber evidence="8">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">fbiC</name>
        <name evidence="18" type="ordered locus">VAB18032_09475</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the radical SAM superfamily. CofH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="9"/>
    <dbReference type="EC" id="4.3.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09475"/>
    <dbReference type="EnsemblBacteria" id="AEB43013">
        <property type="protein sequence ID" value="AEB43013"/>
        <property type="gene ID" value="VAB18032_09475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09475"/>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010522_1_0_11"/>
    <dbReference type="OMA" id="PWPQIDE"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00293">
        <property type="entry name" value="((2_3_4_5-tetrahydroxypentyl)a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="60"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="533"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AEB43013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="845" mass="91216" checksum="2C831B6A7E161E74" modified="2011-06-28" version="1">MSSEAGVRRAVRRAAAGRALDVEEASTLLTARGAALDELLDIAGAIRDAGLRDAGRPGVVTYSKKVFIPLTRLCRDRCHYCTFATVPHRLPAAFLDRDEVLAIARAGAAQGCKEALFTLGDRPEERWPAARQWLDERGYESTLDYLRACAVAVLEETGLLPHLNPGVLSWSELQRLKPVAPSMGMMLETTAPRLWSEPGGPHYGSPDKEPAVRLRVLDDAGRVGVPFTTGILIGIGETLAERVEAIFAIRRAHREYGHLQEVIVQNFRAKPDTAMRSMPDAELHDLAATVAVARVLLGPKARIQAPPNLIAGEYDLLLRAGIDDWGGVSPVTPDHVNPERPWPQLDELAARTAGAGFTLRERLTIYPEYVRAGDPWLDPRLLPHVGALADPATGLAVESARPVGRPWQEPDEAYGGRTDLHVTIDTTGRTGDRRGDFDHVYGDWSEVAAKAVVPSTRAAEDGPAGAAGRSATVGVGDADLRAGLRLAAQDPAALLEPRHADAALALFAADGEALDELCRTADDLRRDAVGDDVTYVVNRNINFTNVCYVGCRFCAFAQRERDADAYRLSVEQVADRAEEAWQAGASEVCLQGGIDPKLPVTGYADLIRAIKARVPQLHVHAFSPMEIATAAAKAGVSVREWLSGLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTAAWVEVVSTAHELGIRSSSTMMYGHVDHPGQWLTHFRVLAGIQDRTGGFTEFVALPFVHTNAPIYLAGIARPGPTWRDNRAVHAMARVLLHGRIDSIQCSWVKLGDEGSAELLRSGCNDLGGTLMEETISRMAGSGNGSARTEEQLRAIAAAAGRPARRRTTAYGHVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5N6</accession>
    <name>F4F5N6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732913.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15685"/>
    <dbReference type="EnsemblBacteria" id="AEB44249">
        <property type="protein sequence ID" value="AEB44249"/>
        <property type="gene ID" value="VAB18032_15685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15685"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_009834_22_1_11"/>
    <dbReference type="OMA" id="GKPYIAF"/>
    <dbReference type="OrthoDB" id="1238555at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="PTHR43176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="348" mass="36777" checksum="05994B49A1E23066" modified="2011-06-28" version="1">MSAPPVIARLIGHLGHLTLNRPAAINALTAEMVTIIRRTLAMWAASDRVRTVLVSGAGGRGLCAGGDIRAIHADAVSGGTASLDFWADEYRLNATIAAYPKPIVAWMDGLVMGGGIGISGHASLRVVTERSRLAMPEVGIGFHPDVGGSWLLSRAPGQLGTHLALTGNAIGAADAIAVGLADYYVPSERLPYLRLALARRDAADAVTSFATTPPESDRTLAHGWIDDSYCDDTVAGIVERLAHHPDPDARAAAKTIATRSPTSLVVTLRSLRSAARLPDLPAALAQEYRLSAALLRLPDLAEGIRAQIIDKDRQPRWQPATLVDVPPELVDACFATIDNPPDLTVEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5N7</accession>
    <name>F4F5N7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44250">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="44" mass="4339" checksum="E932B59A3F8372C2" modified="2011-06-28" version="1">MATNLVTAGHQVIGFHPAPAAERSVACVVVVPESATAAVRGGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5T6</accession>
    <name>F4F5T6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44299">
        <property type="protein sequence ID" value="AEB44299"/>
        <property type="gene ID" value="VAB18032_15945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15945"/>
    <dbReference type="eggNOG" id="ENOG5032UJ3">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083610_0_0_11"/>
    <dbReference type="OMA" id="IRRGYLW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="21641" checksum="D187CEC5FA470F0F" modified="2011-06-28" version="1">MWSLNTRYYSVVVPLVERVAAAFGDTKPTTHVLQTDPVPLPMLLARYPDARTLTNDTNAQLTSSRGGILRSEAVLRYARILVEHEISDLAAAQDLLAGPDGRWRNIDASLSAVPGDGRFGIRRGYLWMLCGNDDLVKPDRMVLRWLSRLRPGVGADEARRLLTEVAAELTDRLGRPVTPWMVDHAIWLEERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5U4</accession>
    <name>F4F5U4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22015"/>
    <dbReference type="EnsemblBacteria" id="AEB45503">
        <property type="protein sequence ID" value="AEB45503"/>
        <property type="gene ID" value="VAB18032_22015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22015"/>
    <dbReference type="eggNOG" id="ENOG50328NA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754920_0_0_11"/>
    <dbReference type="OMA" id="RTGTHRE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="148" mass="16897" checksum="EC480F1E44FF69C8" modified="2011-06-28" version="1">MTMRTSDFSRAPAQARAGAMFIGATRYSNPLVLLRLAPAWFRVVRDMRRMSGYCWHTVYWQFPLTLGTIAFFTDRDAMLRFARTREHRRLMVWLTDGTRNATAGFIRLYTAAPDGYSNGTWRAEGPEMGHIATFTPIGAERTGPEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5V5</accession>
    <name>F4F5V5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734167.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45514">
        <property type="protein sequence ID" value="AEB45514"/>
        <property type="gene ID" value="VAB18032_22070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22070"/>
    <dbReference type="eggNOG" id="COG3371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067784_0_0_11"/>
    <dbReference type="OMA" id="PPWAFRR"/>
    <dbReference type="OrthoDB" id="1705665at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="210" mass="21070" checksum="9B31E3F826397A56" modified="2011-06-28" version="1">MRVVPRWALASAVAAPILLIGGWTLAAARQPGGFDPVTETISALAAVDATDRWIMTLGLAGLGLCHCVTAAGLRPLAPAGRALLALGGVGTLAVAAFPLPAGGGDSVPHTLAATVAFGALALWPALAAPRTTTTRGRARRHAPWAALTVGLALPVAWFVAELATGGERIGLAERVAAGAEALAPLLVVAGLRTASGRRRQRGTAARPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F693</accession>
    <name>F4F693_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_28871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28871"/>
    <dbReference type="EnsemblBacteria" id="AEB46845">
        <property type="protein sequence ID" value="AEB46845"/>
        <property type="gene ID" value="VAB18032_28871"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28871"/>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022752_1_1_11"/>
    <dbReference type="OMA" id="FHYWDSS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="275"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="504" mass="51228" checksum="8A3079ACC5C6C0EB" modified="2011-06-28" version="1">MTVVPRLVFSAPSSGHGKNAVAIGLLAAFAEQGLDVAGFKIGPDQVDAAYLGLACGRPGRSLDARLVGSERLAPLLLHGAADADLAVVQGSMGLYDSLSGRGDTESTAAVATALRSPVVLVVDVAAMGQSVAALVHGFRAYDEQLWIGGVILNRVASSRHEALLREALDDIGVPVYGALRRQDLPPVLPSRRHAVVPVVTGAGEATRAVRRLGEAVAATVDLERLLGLARSAPALGMPAWSPQPAAADDTAAVDRARPVIAVAGGPGGTFSHVETVELLRAAGADVVTVNPFTDEALPAGTRALVVGGALPESYVEQLSANRRLCIAVAELARTGRPVVAEGAGLLWLAREVDGLPMCGVLDAIGSLRDGLVVGYREATAQSDSVIAVRGEVVVGHKEHQGVLSPRGGQRPAWSWAGGAPEGFVWRGVHASQLVPHWAAYPHLATRLVAAATADPDAAPNAAPAVVLGPPAASGSSGVPSGSDGPAPASDAGPVVSRLSGPTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6M3</accession>
    <name>F4F6M3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated Cas2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16225"/>
    <dbReference type="EnsemblBacteria" id="AEB44351">
        <property type="protein sequence ID" value="AEB44351"/>
        <property type="gene ID" value="VAB18032_16225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16225"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151313_0_1_11"/>
    <dbReference type="OMA" id="TNNEQGF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010152">
        <property type="entry name" value="CRISPR-assoc_prot_Cas2_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09707">
        <property type="entry name" value="Cas_Cas2CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01873">
        <property type="entry name" value="cas_CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="15491" checksum="1DA7E422080BF1B0" modified="2011-06-28" version="1">MTVIILTACPEGLRGHLTQWLLEISAGVYVGHVNSRIRQRLWSRVVEMAGPGRALLVYQQPGEQRLCFQVHDHHWQPVDLDGITLIRRPTDRKTYNPALSHGWSKASKRRRFGRRSPEIGHTSVAIPKPGEEDSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6P7</accession>
    <name>F4F6P7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_16345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733035.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16345"/>
    <dbReference type="EnsemblBacteria" id="AEB44375">
        <property type="protein sequence ID" value="AEB44375"/>
        <property type="gene ID" value="VAB18032_16345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16345"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_0_11"/>
    <dbReference type="OMA" id="LIEFYRP"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="94"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="288" mass="30470" checksum="43CC85E8D93F253C" modified="2011-06-28" version="1">MTTTVSASPTAETSIGASTAARRALAPRGWRRRRILLRLLALVVLYGLWEVAARTTGNPTFIPSPGAVWHQLVQTSTTHDGIRGYSGHLLIEHLGVSLRRILIGSIIGIAGGVLLGVVMGTVSGFRVVIEPVVTFVRALPPLAYFSLFIIWFGIDETPKLWLLSIAALPPVAVATAAAVHSAPTGLVEAARALGAGRVHVIRDVVLPHALPEIFTGIRIAVGVAYSSVVAAETINGVPGIGGMVRDAQRYSQTDVVILGLFAIGLSGLIIDALLRTAENRLIPWRGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6S5</accession>
    <name>F4F6S5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734252.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22500"/>
    <dbReference type="EnsemblBacteria" id="AEB45600">
        <property type="protein sequence ID" value="AEB45600"/>
        <property type="gene ID" value="VAB18032_22500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22500"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_1_1_11"/>
    <dbReference type="OMA" id="AQPWSPY"/>
    <dbReference type="OrthoDB" id="538961at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313629" evidence="1">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="414" mass="44090" checksum="382FFD350051C829" modified="2011-06-28" version="1">MTLFRGRRILAGAMTLVAAAALAACGSKTTDEKTSAGVTADTSGDTVKVGLLNSLSGTMAISEVTVRDSIMLAIEEINAAGGVLGKKIQPVGEDGASDWPTFAEKAEKLIREDRVAAVFGCWTSASRKAVKPVFEKHKALLFYPVQYEGLEQSPYIFYTGATTNQQIVPGLDYLKAQGAKSLYLVGSDYVFPRTANKIIKAYAEANGMTVLGEDYAPLGSTEFGTITNKVKSSGADAVFNTLNGDSNVAFFKEYKSAGLTATSMPVVSVSIAEEEVKSIGTQYLEGQLTAWNYYQTTPGAANEKFVAAYKAKYGADKPTSDPMEAAYVSVYLWKAMVEKAGTFEVEQVRKASDGITFEAPEGLVTVDGATQHIAKTARVGKVGPDGLITEVWNSGKPITPDPYLKSYPWAGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6X3</accession>
    <name>F4F6X3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR response regulator receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22740"/>
    <dbReference type="EnsemblBacteria" id="AEB45648">
        <property type="protein sequence ID" value="AEB45648"/>
        <property type="gene ID" value="VAB18032_22740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22740"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="LLGESTM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="20331" checksum="C36AFFF1FD36A7E1" modified="2011-06-28" version="1">MSLLRSALCVALSSEDEIEVVAQVARALELSDVLRRHRPDVVLVDLASEVAPSVEVVAEIAGAAPDAAVLAMGRRWSPAVVGELLAAGAHGLIGMDAPVEALVGAVREVATGGRVIDAEVAVTALLPPGSPLTRREAEVLRAAAEGLPLKEIARRLFLAHGTVRNHLSAVMRKTGTRNRMEAVWQARRHGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F732</accession>
    <name>F4F732_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735545.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29126"/>
    <dbReference type="EnsemblBacteria" id="AEB46896">
        <property type="protein sequence ID" value="AEB46896"/>
        <property type="gene ID" value="VAB18032_29126"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29126"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_0_11"/>
    <dbReference type="OMA" id="MRTYAVR"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="138" mass="14814" checksum="717669EB7A6A42EA" modified="2011-06-28" version="1">MTTVGEFMTTRLVTMDGNDTLVAAAQEMRDSAIGDVVVTDGDNVVGIITDRDITVRGVAESLDPNTTRLNQLTTKDVITVSQYDDAVSAADLMRTYAVRRLPVVEDGRLIGLVSMGDLAVEREPQSVLADISADDPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F733</accession>
    <name>F4F733_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ordered locus">VAB18032_29131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735546.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29131"/>
    <dbReference type="EnsemblBacteria" id="AEB46897">
        <property type="protein sequence ID" value="AEB46897"/>
        <property type="gene ID" value="VAB18032_29131"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29131"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_0_11"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB46897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="35601" checksum="F9C4FB1DCBE5366F" modified="2011-06-28" version="1">MRIGIVGATGQVGGVMRQVLADREFPAEQVRLFASARSAGRTLPWRGEEVAIEDAATADYSGLDIVLFSAGKGTAKELAPRGAAAGAVVIDNSSAFRTDPQVPLVVAEVNPHAAAVRPKGIIANPNCTTMAAMPVLRPLHEEAELVSLVVSTYQAVSGAGLAGVAELDEQVRKVAEGATGLTYDGAAVEFSAPRSFARPIAFNVLPLAGSIVDDGSAETDEEQKLRNESRRILEIPGLKVSGTCVRVPVFTGHSLQINARFARPISPQRATELLDGAPGVTLSEVPTPLQAAGQDPTFVGRIRADETVEHGLALFCSNDNLRKGAALNAVQIAELVATER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F752</accession>
    <name>F4F752_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735565.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29226"/>
    <dbReference type="EnsemblBacteria" id="AEB46916">
        <property type="protein sequence ID" value="AEB46916"/>
        <property type="gene ID" value="VAB18032_29226"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29226"/>
    <dbReference type="eggNOG" id="COG4914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054928_1_0_11"/>
    <dbReference type="OMA" id="REQIDWE"/>
    <dbReference type="OrthoDB" id="1578466at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="21481" checksum="F1A8E84B33711969" modified="2011-06-28" version="1">MAERDDETLLHTLKKVAAVLKQADIPFALGGSFAVYAHGGHSSEHDVDFLIRQGDVDAALEALVAAGFTAERPPEDWLVKVYDGGRMVDLIHRPIETPVTEETFTDTVVRPVDAIHMPVLSATQLMVHKLLSFSQHYCDFARGLPLARSLREQIDWERVRKDTQHSPYAEAFLVLLDRLDVVPDAGTADGRGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F785</accession>
    <name>F4F785_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_10125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731814.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10125"/>
    <dbReference type="EnsemblBacteria" id="AEB43143">
        <property type="protein sequence ID" value="AEB43143"/>
        <property type="gene ID" value="VAB18032_10125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10125"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_0_11"/>
    <dbReference type="OMA" id="VMITMYT"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="44"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="31097" checksum="F0D4249FAC690D41" modified="2011-06-28" version="1">MSSDTATSSGRAPSVYVPSTEALATILAPGQRPPRPSPLAASLAFSWRALLKIKHVPEQLFDVTAFPIIMVLMFTYLFGGALADSPRDYLQFFLPGIMVTSVVMITMYTGVGLNTDIEKGVFDRFRTLPVWRPAALVGMIVGDVLRYILAAVVILTVGLVLGFRPDGGVLGVLAGIGLLVIFSFAFSWVWTFFGLVLRSEKSVMGVSMMVLFPLTFLSNVFVDPSTMPGWLQAFVKANPITHLVSSVRAAMGGTTDASSMTWMVVWSALFIVVFGTLTMYRYNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7B6</accession>
    <name>F4F7B6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731845.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10280"/>
    <dbReference type="EnsemblBacteria" id="AEB43174">
        <property type="protein sequence ID" value="AEB43174"/>
        <property type="gene ID" value="VAB18032_10280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10280"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_11"/>
    <dbReference type="OMA" id="LWIDLIS"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="25355" checksum="6411AC3F859657A7" modified="2011-06-28" version="1">MARLLLIEDDLTIRTPLVRALRERGHAVAAASTAMTGLRDALDDRPDLVVLDLGLPDLDGRELLRMLRAVSAVPVIVATARDDEREIVRVLDAGADDYVVKPFTAAQLDARVRAVLRRGPGGPADEDPTLVVGGLRIDPRSRQVSLDGTPIELTPREFDLLRHLATKVGEVVTKRELLTEVWQIPYGGADKTVDVHLSWLRRKLGENAQQPRYLHTVRGVGVRLVVPEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7E8</accession>
    <name>F4F7E8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BC transporter oligopeptide binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">abyF1</name>
        <name evidence="3" type="ordered locus">VAB18032_16405</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733047.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16405"/>
    <dbReference type="EnsemblBacteria" id="AEB44387">
        <property type="protein sequence ID" value="AEB44387"/>
        <property type="gene ID" value="VAB18032_16405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16405"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_3_11"/>
    <dbReference type="OMA" id="YQMLWFL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007656817" evidence="1">
        <location>
            <begin position="27"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="80"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEK75508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="538" mass="58402" checksum="49BAAA86ED17D693" modified="2011-06-28" version="1">MRTTTRSTAILLLLVAATAACGTSAAQTGDAQPTTGGALTFATAVEPDCLDPAVSARDVTGVINRNIFDSLVRQAPDGSFHPWLAERWETAPDGRAYTFHLRSGVRFHDGTTLDAAAVKATLDHAVDPATESRFAAGLLAAYRSAEVTDASTVTVRLSRPDAALLQTLSTPYLGIQSPRSLRENKDGLCEQPIGSGPFRFVRWEKKVGIDLSRYPDYAWSPSGATHQGPARLDTLRITFVAEDSVRLGSLTSGQVQVSDVPASKARTVQGSAHLLKTEVPGAPYTIFLNSSRDAILADIRVRQALRRAVDLDQLVKSIYFGQNQRAWSPLTPATPLYDDSTRDAFTFDQAEANRLLDEAGWTQRDSAGYRLKDGRRLTLRWPHTAAMERDQRNLIGQGLQSQAKQVGIEIQYTLVDQGTIGDLIGKRALDLFDVSFTRSDPDILRYFFGTKSTLAEGGGNIFGLDIPELDKLLTDGVSTLDPAQRQRIYSDAQRYVVENAVSLPVYVPTSLLGVARHVHGVEFGANATPLFAGAWIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7H1</accession>
    <name>F4F7H1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16530"/>
    <dbReference type="EnsemblBacteria" id="AEB44410">
        <property type="protein sequence ID" value="AEB44410"/>
        <property type="gene ID" value="VAB18032_16530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16530"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_0_11"/>
    <dbReference type="OMA" id="WDYEYLW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="120"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="38041" checksum="F3F2163C94170DBA" modified="2011-06-28" version="1">MAVSTKGGIIVEVRTSDGLVGIGEAGFSAEYFPTVGPLINGQLGPMVIGRDPRDIGALWHDMMRATHMWGRRGVETYALSGMDIALWDLMGKTAEQPVHRLLGTSQHSVRAYYAPSLKPADKAVTEAQEAVAAGYTAIKLRVDGDLSAAVHLVQSVRSAVGAGVDLMVDANMAYHRRGALTLARELHDLQVAWLEEPIMSHSLSQYVSSHSWLADRVDIPLAGGESLLTRFEYIDLMAKLPFDIVQPDAASVGGISELKRIADMASSWNLQCVPHIGCSSGTGIGINAALQVILSCDNAPLIEFDAYGGLGWQGFLAVPPVVKDGRVWASEEPGIGVTIADGAEQRFRIQTRAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7I5</accession>
    <name>F4F7I5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733084.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16600"/>
    <dbReference type="EnsemblBacteria" id="AEB44424">
        <property type="protein sequence ID" value="AEB44424"/>
        <property type="gene ID" value="VAB18032_16600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16600"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013835_1_0_11"/>
    <dbReference type="OMA" id="HWPSVRG"/>
    <dbReference type="OrthoDB" id="1226482at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="831"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="919" mass="94829" checksum="2050CA14B78D521F" modified="2011-06-28" version="1">MNRWLTRRWPAPHWPSVRGRGRTDAGALLLTACVIAVVALLAGAVPALLRAAADDAVQDTVRRAGNESHVLVHADWERDAGPTGGRLRISRLADDVDDFRARATYTLGPDLDAALLPSIAVVNSPILRITDGNLPRTVQLTYLADDLGGPDVTWIAGSAPGPTIPERSIEIPYHGPPWPVQVGLSEADAAALQVGPGDRIPAEDDHGRDKDIRISGIYRPADSADPAWRLAPALLRPVPGADGPGTTRVAALLSRESLPDARLAFDQDQLRRTVHFAPAPDALTWGATATLASQVVKLKASSGSSAARDGSLKWESQLDTVLRDARTQISAAFTQAAVLLAAVLTATVLVLLLAADLLVRRRTPALSAARQRGAALPDLGAELIIESTVVSLSAAAVGLALAHTTAPGASWTWTIPVVLAGAVAGPTFGTLAAARASRDRHQPANPAARRWILTTGRLRRAAVEAAVLIAAVAAVGTLHQRGLLPDASHGDTGELTGDLVLPISAVALGALAGALVVLRLLPVGLRIALRQALRSRRPLAVFGAARAATTAARALPLLVLVSATALASFALVVGATITRGLDDGAWHTTGADARLDISSDVQDATPALAERIAAAPGIEQVVAAQVTDSAPLFTESTLFTPRLVIVDAAAFGRLLATTPLPDAPALSQLTAPGPDPAGVPALVRSSTGDLHTGTRLQLSRDNGPTIRLTAVGTAPPVGGAGDVVIVDAAALAEAGLPAVPNTIWVTGPGTAQAVSDSDVPADIVLRTDVLQAQRVAPLTAGTLRLAWTTAAVLLALGLLGLTLAAAAGAQERWQTLTRLRTLGLRPRDARWVAAGELLPPVVVAAVCGPLLGALLAQLTLGPLELQLLTGQAADPATVLPWWLLCLTGVALVAAATAVVPVEAALRRHDRLSEVLRAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7M6</accession>
    <name>F4F7M6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734315.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22815"/>
    <dbReference type="EnsemblBacteria" id="AEB45663">
        <property type="protein sequence ID" value="AEB45663"/>
        <property type="gene ID" value="VAB18032_22815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22815"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044049_0_0_11"/>
    <dbReference type="OMA" id="AGFCVHA"/>
    <dbReference type="OrthoDB" id="2007674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="434" mass="43951" checksum="DD7E8F42D8298CD4" modified="2011-06-28" version="1">MIRRLLRLVPPGTVPVGAGLALVGVASYVHLAVAGHTLTPGDYSSLSVLWSIVFTVGIGVFLPVEQEVARLVAARRTRDLPPGPVLARGATVAAAVLTLLVLAVTAATDTLAERLFDGDRAMVATLVGALVALALAHTTRGVLAGLGQFTWYGSQLGLDGGLRIGGVTALAAAGVDSPVAYALVLVAAPLLAVALTAPPVARAVGGGTPMPWPPLLRGLALLTVSSLLSQVVVNVGVINVRLLAPDDVATAGALLSALVLVRIPLFVFGSMQAALLPGLSTAAATDDKAAFGGLLRRALAVVTALGVGGGVLTVLLGPWLVTALFDAPAILGHGDFAWLAVATQAYLWAMVLGQALLARDRHRAQAVAWTLGVAALAAATLAPLSVALRVELGYTVGSVVVAAVMLALLRRRRQSDPNPPVAVTLPATAPGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7N9</accession>
    <name>F4F7N9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734328.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22880"/>
    <dbReference type="EnsemblBacteria" id="AEB45676">
        <property type="protein sequence ID" value="AEB45676"/>
        <property type="gene ID" value="VAB18032_22880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22880"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OMA" id="YRVYARI"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="304"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="400" mass="42643" checksum="5FDC995D159E2082" modified="2011-06-28" version="1">MGRQLRQWLRARPLAGDALLTVGLVLGEALFTLLSPREFWPRSLPEALGWSLLCASPVLLRRIAPWPAVLAALASLALPVVIEVVPATQGLTLVVLTYTVAACQPIRPALATAVALWVPVAVLAPLLPTEGLPQVGAAYVVANNLLVGIVSFSVGRTVHARRSTTAALRERARVAEANQRALAEQAVADERRRIARELHDVVAHHVSVMGVLATGVRRVLPRDPKAADEAVATIEETSRATLRELRRLLDVLRTEAEPAADLAPQPGLAGIEMLVEQVREAGLPVTFAVTGTPGPVEQGVALTVYRIVQEALTNALKHAGRATAQVHVSYPGDAVEVEITDTGRGPSPDRQRVGHGLVGMRERVALYGGVLRTGARAGGGYRVYARIPVEPLPETRFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F887</accession>
    <name>F4F887_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10650"/>
    <dbReference type="EnsemblBacteria" id="AEB43248">
        <property type="protein sequence ID" value="AEB43248"/>
        <property type="gene ID" value="VAB18032_10650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10650"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_24_2_11"/>
    <dbReference type="OMA" id="IFCDADF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_7C" evidence="4">
        <location>
            <begin position="165"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="34519" checksum="162BB81A587F6943" modified="2011-06-28" version="1">MVVPTFNSFVLLDRCLRTFRAQNLAVSDSLEVLVVDDGSTDPTAETVRRHVLADSRFRYLHLPRSATSSRSAARNRGAEEATGDILIFVDGDQLVPPTFVEQHLRRYQGISAKKAVIGFRKYLRTPEAFDDRFMEYGGEEFLGGVIKSDIRLDLLSRLSDIGGDVKTSWHLFFTCNVSVPRVDFTRVGGFNEEFRGWGLEDSELGYRLERSGTQLVFDEDSFAYHQGPPLSPNKTVYEGWLKNLSLFIALHEGAPEVILQAMLAPIFNPAVGANWVALYEQFEMCARSTPTASHGSPAEVEESGFSVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8D6</accession>
    <name>F4F8D6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44481">
        <property type="protein sequence ID" value="AEB44481"/>
        <property type="gene ID" value="VAB18032_16885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16885"/>
    <dbReference type="eggNOG" id="ENOG5033TS7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1509795_0_0_11"/>
    <dbReference type="OMA" id="WSMLGAD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="186" mass="20144" checksum="BA396CC4FF438241" modified="2011-06-28" version="1">MITAMSAAFTALWTHDVCRELRRHCVGQRPPVAFSGVHQSLPSWTSVGVGDDVFALHVNRHVVYVVSRLRVVDKQRRSCCGAAPATWRDPAYAGHDDWAMLGAGGCGASPVHVEATPIRFDVAVPGDLLGALTWRNRRGEQRTLKYVVDGRLERSVSLQGVYRLTDESAARLGALLDGSPIPTGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8D8</accession>
    <name>F4F8D8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16895"/>
    <dbReference type="EnsemblBacteria" id="AEB44483">
        <property type="protein sequence ID" value="AEB44483"/>
        <property type="gene ID" value="VAB18032_16895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16895"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_11"/>
    <dbReference type="OMA" id="DTEIGWH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="19937" checksum="87374E2554253A9D" modified="2011-06-28" version="1">MNRVGGMRTIVSDRLLLRPWQDDDADFLLDLESGSQIVVSSGAQPTTMKTRKDALASIRRLRAIEHPIYGNWAIATANGRLVGNLLLLPIPPWAEQSFSGSNDVEIGWHVHPDARGQGYATEAADAVLRDAFGRGLPRVLAVTEPDNHASQAVCRRLGMTALGRTTRYYDTINELFEKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8L1</accession>
    <name>F4F8L1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734406.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23280"/>
    <dbReference type="EnsemblBacteria" id="AEB45754">
        <property type="protein sequence ID" value="AEB45754"/>
        <property type="gene ID" value="VAB18032_23280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23280"/>
    <dbReference type="eggNOG" id="COG5592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079417_2_0_11"/>
    <dbReference type="OMA" id="RKWPEEE"/>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="21872" checksum="37B3BDE9675101C9" modified="2011-06-28" version="1">MTVTKPDQDVIDLLVDQHEQIRSLFAEVRESEGEAKQQAFQDLVRLLAVHESAEEQVVHPAARADAGDAVVDARLREESEAKRELSELYDMGTSAPGFDARFAAFEQAVLEHARHEEQEEFPQLRRDTDPQRLRQMAGAVRAAEAISPTRPHPAAGESPVSNLLLGPPVAVFDRMRDAVRDWRQSHDSEHQSHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8M8</accession>
    <name>F4F8M8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_23365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734423.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23365"/>
    <dbReference type="EnsemblBacteria" id="AEB45771">
        <property type="protein sequence ID" value="AEB45771"/>
        <property type="gene ID" value="VAB18032_23365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23365"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397328_0_0_11"/>
    <dbReference type="OMA" id="WYRNATG"/>
    <dbReference type="OrthoDB" id="350455at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="371"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="677" mass="72538" checksum="B598DBFC4FF215DE" modified="2011-06-28" version="1">MADQPGTGQRTRRWRWGWGGWRAEAGRLLEVAALLGLVITQPLLDVLGRSPDFFLFHRADRREILLLVALVAVLPTVAVGLLGLAGGLLGPTVRAGTHTLLVGLLVAALAVQVGRQLTPLRGVPLLLLAGVAGAVGAYAHRRWRAAGRVLRVAGVGPLIFVGLFLFASPTAPVVLPRGDGGAAGTATGNRHPPVVLLVLDELPLVSLLGPDGGIDAQRFPHFAELAAASTWYRNATGVSGWTPYALPAMLTGRYPAQPYAPHYSHYPDNLFTAFGGLYDIRAEESITRLCPPSRCEQPVMPEQGLGVLVRETGQLLRQVTSPQDSRIDPENSYRERTAEEAGIDAAEPVPDDPKFRWDSLNVNQPARFTSFLNGLTPAPRPTLHFLHLLMPHSPWAYLPSGARYEAPEEFPNEGDGWVDLARARHLAQLGYTDRLIGETLRTLRETGLWDQALVVVTADHGVSFTKGAQGRGMDAIRAAADEVAWVPTFVKTPGQRTGRVDDRNWEHVDLLPTIADEAAISLPWRVDGRSARQAPRTEPGKVFYDRPAEPTPISGAVPDPLPPPAPHPLVGTAVADAAPGGTVRIGGQDGFRAVDPDSGQLPALIWGTLPEQVPDGTLLAVAVNGTVASVVPVVAPDPAGRRFAALLADDRFFRAGANRLDLYLVEPAGGLRQLTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Y2</accession>
    <name>F4F8Y2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735710.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29956"/>
    <dbReference type="EnsemblBacteria" id="AEB47062">
        <property type="protein sequence ID" value="AEB47062"/>
        <property type="gene ID" value="VAB18032_29956"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29956"/>
    <dbReference type="eggNOG" id="ENOG5030HQN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051674_3_0_11"/>
    <dbReference type="OMA" id="LMVTNEF"/>
    <dbReference type="OrthoDB" id="1828250at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="29100" checksum="11843793B8463CD9" modified="2011-06-28" version="1">MSNLVRSELLKIRTTSTWWWLAIGALLSIAMAFPLNAWLFNTTVDGGGEELGVTGDAASAPAQAANLYTSGQYLGLLFVMLIGILMVTNEFFHQTATTTFLATPRRSAVIVSKLIAASLLGFAFWLVTTVIDLGAGAAFLALNDHGTLLGEWEVQRALLLNLMAYAIWTVLGVGIGTLITNQLGAVITASVLYLIGTQVIGVLFLLLSSWLDSMAVLKWQVIWPAAASQIMITPGESEMFPPWWVGALVLVGYALASGIVGLLLTRRRDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F991</accession>
    <name>F4F991_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, PaaX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731956.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10835"/>
    <dbReference type="EnsemblBacteria" id="AEB43285">
        <property type="protein sequence ID" value="AEB43285"/>
        <property type="gene ID" value="VAB18032_10835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10835"/>
    <dbReference type="eggNOG" id="COG3327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067515_1_0_11"/>
    <dbReference type="OMA" id="RTEVMDT"/>
    <dbReference type="OrthoDB" id="1210594at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="188"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="33386" checksum="16F9EC0311EE5D6A" modified="2011-06-28" version="1">MSDLHHALEPPTDGAAAVGRARAQRLLVTLLGDYWRAGHAPLPSGGLVAVLAEFDIAPANARATLSRLTQRGVLERTKEGRRTSYRLTESAAQILRRGGRRIFASTDESSWDGRWTLIAFTLPLDDANQRRLLRARLRWLTFSPLYDGTWVTPHDRFDEVREQLSELGVSDAVVLRATDLDLLPGGRARLEAAWRIDELAAGYQSFLERYRDLVWPAAAGEVSPAQALVRRTEMVNDWRALVGEDPDLPAMFLPASFPRAQARAMFLETSAALARPAQQRFEELVQTPDHAADGAKSRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9C6</accession>
    <name>F4F9C6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_11010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11010"/>
    <dbReference type="EnsemblBacteria" id="AEB43320">
        <property type="protein sequence ID" value="AEB43320"/>
        <property type="gene ID" value="VAB18032_11010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11010"/>
    <dbReference type="eggNOG" id="COG2149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053359_4_1_11"/>
    <dbReference type="OMA" id="NHWVRCE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="11815" checksum="FD90E3041ED46BE4" modified="2011-06-28" version="1">MGTTPDYRFSLANERTFLAWLRTGLALVGGGLAAAQFLPALPLRHLREAISIALLLLGGAVAVRAIDHWARVERAIRLDQQLPASRFPAVLAVVVGLGALLLVVAVLAGALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9E4</accession>
    <name>F4F9E4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732009.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11100"/>
    <dbReference type="EnsemblBacteria" id="AEB43338">
        <property type="protein sequence ID" value="AEB43338"/>
        <property type="gene ID" value="VAB18032_11100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11100"/>
    <dbReference type="eggNOG" id="COG4625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723237_0_0_11"/>
    <dbReference type="OMA" id="TFTLRMT"/>
    <dbReference type="OrthoDB" id="331848at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307746" evidence="3">
        <location>
            <begin position="27"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="379" mass="38532" checksum="36D06C791E261A74" modified="2011-06-28" version="1">MKTLRPVMALTMVLALLLGIAPPAAAAAVTITSGAPRSPMYLGQVYAIHTVEATGGTEPYRLSVSAGSLPPGMLVVGNSLGGSPTTAGTYTFTLRMTDAADQFAEQTATIEVREPTIEIASGAPRTPMYLGQVYAIHTVEATGGTEPYRLSVSTGSLPPGMLVVGNSLGGSPTTAGTYPATLRMTDKNDFFGEQEITIVVAEAATAFTSGNPPSGRVGQPYSFRFTATGDDDITFALAAGTLPTGLTLATDGRLSGTPSSAGTFDFMVRAAGAKTSATAEVELVVAATATSTPTSTPTAPSATPTAPTATPTAVEPTPTPSESPAAPVPSPSKTSGAWLPVTGSNSTLVLLLLSVLAFSIGGILLVLTVNRHRRFRAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Q1</accession>
    <name>F4F9Q1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45827">
        <property type="protein sequence ID" value="AEB45827"/>
        <property type="gene ID" value="VAB18032_23645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23645"/>
    <dbReference type="eggNOG" id="ENOG5033X27">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862802_0_0_11"/>
    <dbReference type="OMA" id="SGHCLGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043769">
        <property type="entry name" value="DUF5715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18979">
        <property type="entry name" value="DUF5715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="275" mass="30918" checksum="B46CC53ED67EBF79" modified="2011-06-28" version="1">MAELLVEVGALASASSTKARQVLIDQRLREPTIAAVLDATPQGLIGARETLLLEMARYQPNARSSAADLTALVRIYLLSRIDVMWWRDAGTFLTDTEVHHSVDLVDLDWLRRRDLLRFRYTEQPRSLVGRGVRALRRRVLPDATPRTAGLLFRRARREVVALLNDIGREFAAVTPAGTPPLWVTSLVRSAEHQYRLRRLGYAAMVPSGHCLGWAVDLEMEWFGRFGVRDTLAGLLLNRQRSGEINVVDEGQAWHVCLAPTATARLRRAYEAEMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA22</accession>
    <name>F4FA22_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapD</name>
        <name evidence="6" type="ordered locus">VAB18032_00245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735779.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00245"/>
    <dbReference type="EnsemblBacteria" id="AEB47133">
        <property type="protein sequence ID" value="AEB47133"/>
        <property type="gene ID" value="VAB18032_00245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00245"/>
    <dbReference type="eggNOG" id="COG2171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057490_1_0_11"/>
    <dbReference type="OMA" id="TVLDTWF"/>
    <dbReference type="OrthoDB" id="1251912at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_M" evidence="5">
        <location>
            <begin position="111"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="319" mass="33189" checksum="B1DCD7D6437AF608" modified="2011-06-28" version="1">MTSTESAWGIGLATVTADDQVLDTWYPTGKLGLGELPLVPGEDEADVLDLPPGALGDRALPGLRTVQVVTVIGSLADPIKDAADAYLRLHLLSHRLVRPNQLNLDGIFGKLANVAWTSAGPCPPERVDELRVIERAAGRHLAVYGVDKFPRMTDYVVPSGVRIADADRVRLGAHLASGTTVMHEGFVNFNAGTLGTSMVEGRIVQGVVVGDGSDIGGGASIMGTLSGGGTDRVSIGERSLIGANAGIGISLGDDCVVEAGCYITAASKITLPDGRVVKARELSGVDGLLFWRNSVNGALEARPRTGRGIELNAALHAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA44</accession>
    <name>F4FA44_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ordered locus">VAB18032_00355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.5.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735800.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00355"/>
    <dbReference type="EnsemblBacteria" id="AEB47155">
        <property type="protein sequence ID" value="AEB47155"/>
        <property type="gene ID" value="VAB18032_00355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00355"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_8_1_11"/>
    <dbReference type="OMA" id="PTAHHFM"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="14"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="491"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="648" mass="71307" checksum="F1D3DD89BD0948A3" modified="2011-06-28" version="1">MTSTTTRIERHHYDVVVIGAGGAGLRAAIEARLAGKKTAIISKSLFGKAHTVMAEGGAAAAMGNVNSRDNWQVHFRDTMRGGKFLNNFRMAELHAKEAPQRIWELETYGALFDRTKDGKISQRNFGGHEYPRLAHVGDRTGLELIRTLQQKIVSLQQEDKQEFGSYDARIRVFSETTITELLLDGDRVAGAFGYYRESGEFVLFEAPAVVLATGGVGRSYKVTSNSWEYTGDGHALALRAGATLINMEFLQFHPTGMVWPPSVKGILVTESVRGDGGILKNSEGKRFMFDYVPDVFRKQYAETEEEADRWYTDPDNNRRPPELLPRDEVARAINSEVKAGRGTPAGGVYLDIASRLPAEEIRRRLPSMHHQFKGLADVDITKEPMEVGPTCHYVMGGVEVDPDTGAAYGSVRGLFAAGEVSGGMHGSNRLGGNSLSDLLVFGKRAGGHAANYVDQLTGRPRVEVTAVETAVETALAPLQRDTGENPYTLQQDLQAVMGDLVGIIRREAELEDALVRLAELRERVAKVSAAGGRRYNPGWHLALDLRNMLVVSECTAKAALERRESRGGHTREDHPTMDPQWRRVNLVCSLEGDTVRLDRKPLPKMRAELIALFDRAELAKYLTDEELAEFDALAAAEAEDTDAAGKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA85</accession>
    <name>F4FA85_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730820.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42146">
        <property type="protein sequence ID" value="AEB42146"/>
        <property type="gene ID" value="VAB18032_05100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05100"/>
    <dbReference type="eggNOG" id="ENOG5033AIW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148470_0_0_11"/>
    <dbReference type="OMA" id="WCEGGLV"/>
    <dbReference type="OrthoDB" id="1400520at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="142" mass="16497" checksum="91877DC47891E791" modified="2011-06-28" version="1">MSVQESTFHGFANPVDPSPAELRSWAYNPDSVPLTSMPPDWDLLVSGDRLVMTLFDLAMDPTCPARRFALHCLYIYAADGIRTNFRAHPRRRFRKLVDQAERNGDDMMRTWAHNSRVLLTRPELFVYREWCEGGLVREGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA92</accession>
    <name>F4FA92_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ordered locus">VAB18032_05135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730827.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05135"/>
    <dbReference type="EnsemblBacteria" id="AEB42153">
        <property type="protein sequence ID" value="AEB42153"/>
        <property type="gene ID" value="VAB18032_05135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05135"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_2_1_11"/>
    <dbReference type="OMA" id="YVNCKPV"/>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="50"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="118"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="18571" checksum="DD5CC2898F28538E" modified="2011-06-28" version="1">MGDHDDLRKFISDLAVVHGRVVLSSGREADWYVDLRRVTLHHRAAPLVGRVMRDLTADWSYDAVGGLTLGADPIALSMLHATGRPLDAFVVRKTGKAHGLQRRIEGPDVAGRRVLAVEDTSTTGGSVLTAVEALREAGADVVGVAVIVDRGAGDAVRAAGLPYRAAYTLADLGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAU2</accession>
    <name>F4FAU2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannitol dehydrogenase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734557.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24035"/>
    <dbReference type="EnsemblBacteria" id="AEB45905">
        <property type="protein sequence ID" value="AEB45905"/>
        <property type="gene ID" value="VAB18032_24035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24035"/>
    <dbReference type="eggNOG" id="COG0246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027324_0_1_11"/>
    <dbReference type="OMA" id="PWEQMKL"/>
    <dbReference type="OrthoDB" id="1442117at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023027">
        <property type="entry name" value="Mannitol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00974">
        <property type="entry name" value="MANNITOL_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="1">
        <location>
            <begin position="34"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="2">
        <location>
            <begin position="224"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="495" mass="51451" checksum="AEC24D3D7155A228" modified="2011-06-28" version="1">MAVTVGASRLDLGALRRLPADARPLVQPGTVPAGVLHLGLGAFHRAHQAVYTEQAVASAGGDWGIVGVAPRNADLVRVLTAQDNLFSVSTLSAADRHTRVIGALAGVRLAAADPQAVVALLADPAIRVVTLTVTEKAYQLDPAGGTLRPDPALVADLTGDRPPVTVPGMLVRGLLARAAADAGPIALVSCDNLPANGRRLRGLVQHALAYAQAPQPAVDWVGAQVGFPGTMVDRIVPASTAETLAAARRALGVEDLAAVAAEPYTQWVIEDDFPGGRPGWERAGAVLCADAGPWERLKLRTLNGVHSAAAYLGALAGCETIADALALPHLATVLRRLIAEDVAASFTPPQGVDVVDYGEQVLARFGNPAIRHRTLQVAMDGSQKLPQRILHTIADLRAGGRSARWAALVLAAWIRFAQGTADDGRTLPLDDPLADRIRAALADAPQTPAGAVDAVLALDEVVPPEVAADAQVRADVTAWLTDLTRHGVRPTLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB31</accession>
    <name>F4FB31_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">VAB18032_00460</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00460"/>
    <dbReference type="EnsemblBacteria" id="AEB47176">
        <property type="protein sequence ID" value="AEB47176"/>
        <property type="gene ID" value="VAB18032_00460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00460"/>
    <dbReference type="eggNOG" id="COG1085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_1_1_11"/>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="48"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="222"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB47176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="367" mass="41047" checksum="0D3B0473E10AD9BB" modified="2011-06-28" version="1">MVDQLPASAMRRTAIRLADGRELIYFDERDDVVRDQPDRRDLPPPPPASQLRYDPLTDEWVALAVHRQTRTFLPPADQCPLCPSTEQRLSEIPAPDYAVAVFENRFPAFSQRVVDEPAEITPLTAVRPGRGRCEVVCFTADHHASFAGLPPRRVRTVLDALADRTAVLGELPEVEQVFCFENRGVEIGVTLHHPHGQIYAYPFLPPRTRALLAAARRHAERTGGRNLYADVLAAERAAGERVVATNDHWTAYVPAAARWPFEVHVAPHRPVPDIPALTEAERDAFGPLYLDLLRRFDGLFDTPMPYIAAWHQAPVRVDRELGHLHLQLFSIRRAADKLKYLAGSESAMGVFINDIAPERAAALLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB41</accession>
    <name>F4FB41_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide abc transporter, atpase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735831.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00510"/>
    <dbReference type="EnsemblBacteria" id="AEB47186">
        <property type="protein sequence ID" value="AEB47186"/>
        <property type="gene ID" value="VAB18032_00510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00510"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="VFYKGQD"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="37577" checksum="882AA90430531E79" modified="2011-06-28" version="1">MTAPADPTKIRGETILDVDNVVKHFPITQGVLFKRKVGAVKAVDGVSFDLRRGETLGIVGESGCGKSTLARLLMRLERPTAGRATLAGRDLFAASGGELRRIRRNMQMVMQDPYTSLNPRMTVGDIIGEPFEIHPEAAPKGSRQQRVQELLDVVGLNPEHINRYPHQFSGGQRQRIGIARALALRPEVIVCDEPVSALDVSIQAQVINLLEELQDEFGLSYIFIAHDLSVVRHISDRIAVMYLGRIVEIGTEEQIYERATHPYTQALLSAAPLPDPEARDRRDIIRLTGDVPSPADPPSGCHFRTRCWKAQEVCALEDPRAVPRAADPHPSACHFAALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB97</accession>
    <name>F4FB97_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735887.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00790"/>
    <dbReference type="EnsemblBacteria" id="AEB47242">
        <property type="protein sequence ID" value="AEB47242"/>
        <property type="gene ID" value="VAB18032_00790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00790"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_6_2_11"/>
    <dbReference type="OMA" id="VMLEHAD"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307590" evidence="1">
        <location>
            <begin position="33"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="94"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="364" mass="39422" checksum="D771742998F1E00F" modified="2011-06-28" version="1">MSRHLIPRPRTAAGRAAGLVGAALGVAAAVTAAGVATERALVRRLKADPTDPYAGEVFGQQRYDEAYRLEMPDGTDIHVEVVEPTRPVEGNPTVVLVHGFCLDMGTFHFQRKLLAERGEHRVVAYDQPGHGRSGRLETGEYDLDALGHTLRRVIDEVAAEGPLVLVGHSMGGMTIMALAELYPEMFDDRVVGTVLMATSGGLLAETKLVAPALLGRVGSPVLYMAGNVTRYTGPVIDRARRSTTNVAWLLTRKYGFGTRNPSPALVSYVEQMNSRTSADTVTRYLRTIATHSRFPALVALEGTPVLVIVGDKDMITPVTHSEEIVRRLPHAEFVKINDSGHVVMLEHADEVNEALLAFLGTCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBA0</accession>
    <name>F4FBA0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="10" type="ordered locus">VAB18032_05350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05350"/>
    <dbReference type="EnsemblBacteria" id="AEB42196">
        <property type="protein sequence ID" value="AEB42196"/>
        <property type="gene ID" value="VAB18032_05350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05350"/>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003100_0_1_11"/>
    <dbReference type="OMA" id="FIEPYQG"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="9">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="137"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="253"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="516"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="640"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="364"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="830"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="906" mass="96051" checksum="1F7A128234318A2D" modified="2011-06-28" version="1">MTTHPDPVRETPEAVPATPAQPVQPYPAAAPARHASGQADWADRVDTVPRAEGTPEELQPYAELGLRDDEYDRIRHILGRRPTQSELAMYSIMWSEHCSYKSSKVHLRQFGEKAPPSDRLLAGIGENAGVVRVSDELAVTFKVESHNHPSFVEPYQGAATGVGGIVRDILAMGARPVAVMDPLRFGAADHPDTARVLPGVVAGVGGYGNCLGLPNIGGEVVFDPCYQGNPLVNALCLGVLPVSRLQNKAAVGPGNVVVLMGAKTGRDGIGGVSVLASATFTEGSEQRRPSVQVGDPFTEKLLIEACLELYDAELVAGIQDLGGAGLTCALTETAAAAGTGMRVWLERVPLREPSMDPHEILASESQERMLLVVEPAKLETVLKTCEKWGVLATAIGEVTAPEPDGQPGRLLITWRDQLVVDVPPGSLVDDGPVYARPMREPADLILLQADRAETLPRPSDPDALRETVLRMIASPNLCDKTWVTEQYDRYVLGNTVLAQPEDSGVIRIDERTGLGVALSVDGNGRYARLDPYHGAKLALAEAYRNVVVAGATPIAVTDCLNFGSPEDPGVMWQFAEAVRGLADGCAELGIPVTGGNVSFYNQTGAAAIHPTPVVGVLGVLENVAERVAMGFVPRPGGDHDQLFLLGETHVELSGSEWAWVAHQHLGGVPPHVDLAREKQLGELLAAAARVGHVSSAHDLSDGGLAQSLVESCLRYGVGARIAVPERFEGNSMPFVFLFSESAGRVLVSVPRGHEKAFTALCAEHGVPWELIGVTDSTGGALEVHGQFRIGLDELREAHSATLPALFGGVQPVELTAQDSVVEAAPVDAVEAPVEADPVPSVEDADPVPSVEDADPHAEVAVPVSDGVESPEDDRPVERAAPPVRQQPIEQDTATDAPQEQPSADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBQ3</accession>
    <name>F4FBQ3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rpsO</name>
        <name evidence="7" type="ordered locus">VAB18032_12005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732184.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12005"/>
    <dbReference type="EnsemblBacteria" id="AEB43515">
        <property type="protein sequence ID" value="AEB43515"/>
        <property type="gene ID" value="VAB18032_12005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12005"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_11"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="89" mass="10407" checksum="D182802F73CEE85F" modified="2011-06-28" version="1">MALDQQAKAKIREEYATAEGDTGSPEVQVAVLTKRIADLTEHLKVHKHDHHSRRGLLLLVGRRRRLLNYVQKKDINRYRSLIERLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBW6</accession>
    <name>F4FBW6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733421.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18320"/>
    <dbReference type="EnsemblBacteria" id="AEB44766">
        <property type="protein sequence ID" value="AEB44766"/>
        <property type="gene ID" value="VAB18032_18320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18320"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_0_2_11"/>
    <dbReference type="OMA" id="RDQSFLM"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="32816" checksum="8AEC78D57AA3324E" modified="2011-06-28" version="1">MSALPLLPARRPVPGVFVALGLTLAIGWLVVAIDGGQLFNQSTTVSLLHVAAGLGFVAVGQTLVILGGSLDLSVAYVVSLSTLVAAETMNGSDAALLPAIGLALLVSAGIGLFNGLLVTTGQINPFIATLGVGLLLKGYLDSRYDGPAGSTAPALVQTLGYQRVGPVPLSFLLLLAVAGACWFLLSRTRFGHHLIAVGGDPEVARLSGVRNDRVRVTAHVLCSLCAGLAGIYLASRLGSGAPRVGTEGLYDLESIAAVVIGGTALAGGRGGVVGTVGGVLLLAGIDAIFNQLAVDAFAKQVVRGVIIIAAVAVYARRALRKADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBZ4</accession>
    <name>F4FBZ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein arsr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734644.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24470"/>
    <dbReference type="EnsemblBacteria" id="AEB45992">
        <property type="protein sequence ID" value="AEB45992"/>
        <property type="gene ID" value="VAB18032_24470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24470"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_2_11"/>
    <dbReference type="OMA" id="TGMKKHI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12718" checksum="E41293925600EB24" modified="2011-06-28" version="1">MVQQDARLDRIFSALADPTRRQVLARLGAAPATISDLAEPFAISLTGMKKHVRVLEEAGLVVTEKVGRARQCRLGTERLDDAMAWITFYQRLWERRLDGLDAYFTLRKGTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC43</accession>
    <name>F4FC43_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734693.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24715"/>
    <dbReference type="EnsemblBacteria" id="AEB46041">
        <property type="protein sequence ID" value="AEB46041"/>
        <property type="gene ID" value="VAB18032_24715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24715"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038800_1_0_11"/>
    <dbReference type="OMA" id="WNHAEEI"/>
    <dbReference type="OrthoDB" id="1730305at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013630">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038576">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08421">
        <property type="entry name" value="Methyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_13" evidence="1">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_14" evidence="2">
        <location>
            <begin position="242"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="44336" checksum="28FFF26205C6B827" modified="2011-06-28" version="1">MTSCRICGGAVGELLDLGRQPSANRFLSPEEAPQEYLFRLAIGACDTCTMVQLMEDVPQEVRYHPAYRYLASGSALHRKFFAGEARRLLETELTGPDPFIVEIGCNDGVLLEHIAQAGVRHLGVEPAASVAALAEAKGVTVRNSFFDDVTAAEIRTGRGADVIYGANTICHIAYQDALFRGVDTLLAPDGVFVMVEPYLGTIVHGMAFDQIYDEHVYYFTAHSVRAMARTFGFELVDVEDVPLHGGEIRYTLARPGRRPIRPAVADMLAREQSSGLIERDTLARFARAVAQIREDLVDLLRGLRAEGRTVVGYGAPGKTATVTTYCGIGPDLLPFTCDSTPAKQGLLVPGSHIPVLPPAEFEAARPDYALLFAWNHAEEIMAKEKAFRDRGGRWIRYVPRVRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCI4</accession>
    <name>F4FCI4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-octaprenyl-4-hydroxybenzoate carboxy-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_05925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730984.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05925"/>
    <dbReference type="EnsemblBacteria" id="AEB42311">
        <property type="protein sequence ID" value="AEB42311"/>
        <property type="gene ID" value="VAB18032_05925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05925"/>
    <dbReference type="eggNOG" id="COG0163">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_0_11"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="OrthoDB" id="1384786at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="21832" checksum="B1B5B11CF63F5F39" modified="2011-06-28" version="1">MREPWVVGVSGASGTPYAAAVVRGLLDAGQPVDLIVSRAARLTILDETGRPFRDAHWAEDLSAWLGRDLDGADVRHWPAGDLAAGPSSGSYPVRGMAVVPASTAACAGIAIGLSKDLLQRAAEVNLKERRQVVVVPRETPVTRSHLEHLIALHDAGAVVLPASPGFYGAGAAASAAQLVDFVAGKVLDALGVPHTLFHRWTGTLNADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCL6</accession>
    <name>F4FCL6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06095"/>
    <dbReference type="EnsemblBacteria" id="AEB42343">
        <property type="protein sequence ID" value="AEB42343"/>
        <property type="gene ID" value="VAB18032_06095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06095"/>
    <dbReference type="eggNOG" id="ENOG50327HW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2717911_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="77" mass="8002" checksum="A3ED00A24F90568F" modified="2011-06-28" version="1">MRLTLAGMTDPRDVADGDAAELVEQLRDLAGADPAEVRQVVSEVLAALDRAAGGALREHLPETIRAGLDASSPVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCL8</accession>
    <name>F4FCL8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ordered locus">VAB18032_06105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731018.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06105"/>
    <dbReference type="EnsemblBacteria" id="AEB42345">
        <property type="protein sequence ID" value="AEB42345"/>
        <property type="gene ID" value="VAB18032_06105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06105"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_0_0_11"/>
    <dbReference type="OMA" id="RFPVKYY"/>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="13613" checksum="EC06FF8C193FA605" modified="2011-06-28" version="1">MSLSPYVPIIGLFALAAAFALFSTVATRFTGPRRYNRAKLEAYECGIEPSPQPIGGSRFPVKFYLTAMLFIVFDVEMIFLYPWAVSFDALPVFGLVAMFVFIGAVFVAYAYEWRRGGLDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCP3</accession>
    <name>F4FCP3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732206.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12115"/>
    <dbReference type="EnsemblBacteria" id="AEB43537">
        <property type="protein sequence ID" value="AEB43537"/>
        <property type="gene ID" value="VAB18032_12115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12115"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_8_0_11"/>
    <dbReference type="OMA" id="KATLHAT"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="16055" checksum="27C2CCDCB3795D59" modified="2011-06-28" version="1">MVLLRRVIGDALRARRQGQHRTLREVSSAANVSLGYLSEIERGQKEPSSELLAAICDALGARLSELLREVSDTVALAEQLPGVLVPMQDEPAESTPVTATVGAATNRSVRQVSADGVAVSVRQESPLKATLRSTRVRPADRTDRDVVCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCT2</accession>
    <name>F4FCT2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_12310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732245.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12310"/>
    <dbReference type="EnsemblBacteria" id="AEB43576">
        <property type="protein sequence ID" value="AEB43576"/>
        <property type="gene ID" value="VAB18032_12310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12310"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_3_11"/>
    <dbReference type="OMA" id="VPLQYGW"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="69"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="31914" checksum="1873EBF37B588198" modified="2011-06-28" version="1">MSTSSVLYDHPGPRAKVRNTVLSVIFGVALLGLVYWIYSKFDQANQWEGWLWKPFAEPKTWTQFILPGLWATLKAAGVGMLLSLAFGIIFAVGRLSEHKWISVPAGAVVEFFRAVPLLLMIFFVFYGLPYVIKQPVTAFWSVVIGLTLYNGSVLAEAFRAGIRALPGGQSEAAYAIGMRKTQVMQLILIPQAARAMLPIIVSQLVVLLKDTALGYIVAYPELLQRGVNDLAANYGNIIPAAMVIAVIYIIINSMLTWFAGWLERRTGTRRARVPRQRAGTAGSTVVEPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCX2</accession>
    <name>F4FCX2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S8 and S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_18510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18510"/>
    <dbReference type="EnsemblBacteria" id="AEB44804">
        <property type="protein sequence ID" value="AEB44804"/>
        <property type="gene ID" value="VAB18032_18510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18510"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535212_0_0_11"/>
    <dbReference type="OMA" id="GDTDCLG"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309252" evidence="6">
        <location>
            <begin position="32"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="202"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="509" mass="50933" checksum="1F0FF8D2B7807E8B" modified="2011-06-28" version="1">MLAKRPNVGRLLAGMVVVCCMVVAMAGTATARKAPLDPQAYVKYYVVTAEYQGQPENLTAIATRFLGSGERSAEIYNLNAGRVQPDGASLTDPARLNRGWYLVLPWDAVGEGVTYGQIPSEPNKPTTSPRPSGTAKPGTAPTSATSPPPATSPTPSRSPGQSPSPSGTGSTAGCTAVAGSSSRSDWAQLRLAIDGAWDLSRGNGVMVAVLDSGVDGRIEQLSGRVTVGADVTVGNGRGDTDCLGTGTAMASIIAANTGIQQTPVGLAPDATVLPVRMVGRSGTARPTDAANAIEVAVSAGASVVALGSHVDLSAPAVAASLTTALNHDVVVVAGAPTKPVTLPAASEPKATGALLLVGGVGADNKLVEEYQPDAVEVVAPGADVLGIGPGKAGTLSYSGTRFAVAFVAGQAALVRAAYPELNATQIEERIRNTADALGDQTPDGRYGAGMINPVVSLARTLEGEQPTGAGSSGGSGGGGGMATLVLIGVALLGGGAFLALGLHRRRAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD89</accession>
    <name>F4FD89_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25105"/>
    <dbReference type="EnsemblBacteria" id="AEB46119">
        <property type="protein sequence ID" value="AEB46119"/>
        <property type="gene ID" value="VAB18032_25105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25105"/>
    <dbReference type="eggNOG" id="COG5479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037318_1_2_11"/>
    <dbReference type="OMA" id="GHGHERC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309273" evidence="2">
        <location>
            <begin position="36"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3152" evidence="3">
        <location>
            <begin position="65"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="28588" checksum="41965A36321CCC72" modified="2011-06-28" version="1">MSYAPRMPAGRGRSWASPLVAVVLAGCAPAMPAPAAPFAPVVTASPTGRPRVAAAPLASTPPAPVSYPARGANRWDVAGGEAAPRTGPGRLLRYQVAIERGIEGIALTEFAAEVSRILSDPQGWSAGGQWRLRRVGPDRRPDFTIYLATPVTRDRLCQDVPDGYTSCRNGDRVVVNVARWVKGAPGFGTDVDHYRQYVVNHEVGHRLGMGHELCPGRGRPAPVMQQQTLGLHGCTPNGLPYLDGRRYSGRSGSYDDRIPPRDRGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDI2</accession>
    <name>F4FDI2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736028.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01545"/>
    <dbReference type="EnsemblBacteria" id="AEB47393">
        <property type="protein sequence ID" value="AEB47393"/>
        <property type="gene ID" value="VAB18032_01545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01545"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_6_0_11"/>
    <dbReference type="OMA" id="MYNKLMP"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="29175" checksum="A591D12291A316DB" modified="2011-06-28" version="1">MADTLLDDVAGLLRETADRIVLPLFRHLDDADVTEKAPGELVTVADQRAEEAIAAGLRRLRPNSLVVGEEGVAADPSLLRHLRSAGDVWLVDPIDGTANFAAGRRPFALMIALLTAGEPVAGWIFDPLADTLATGWLETGAYLDGNPLRLPTDAPPIGELRGAAMTRFLPPSSRRTVEAGGAQVGELLPGQHCAGREYLDLLTGDQQFVVFWRTLPWDHGPGTLLVRAAGGVARRFDGTDYHPADTTEGLLVATNEKIWHQVQTTLLPTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDK4</accession>
    <name>F4FDK4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06215"/>
    <dbReference type="EnsemblBacteria" id="AEB42367">
        <property type="protein sequence ID" value="AEB42367"/>
        <property type="gene ID" value="VAB18032_06215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06215"/>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120441_0_0_11"/>
    <dbReference type="OMA" id="IRTVGCG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="131" mass="13607" checksum="C87BE428353A05BA" modified="2011-06-28" version="1">MPAMGFLKGLLIRVGATAVAFWLATLVIPGISLDTASAGETVLTLVLVAVIFGVVNGVLQPIIKTVGCGFYLLTLGLIALVVNGLLFLLTGWIADQVGLPFEVDGFWPAAVLGALFVGVVTWILGAVLDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDM1</accession>
    <name>F4FDM1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06300"/>
    <dbReference type="EnsemblBacteria" id="AEB42384">
        <property type="protein sequence ID" value="AEB42384"/>
        <property type="gene ID" value="VAB18032_06300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06300"/>
    <dbReference type="eggNOG" id="ENOG5033B4A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157938_6_0_11"/>
    <dbReference type="OMA" id="TINWIRS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="52" mass="5291" checksum="F815F122E56978E9" modified="2011-06-28" version="1">MLARLRGDAGMNTAEYAVGTLAAVAFGGILLKVLTSDSVQSALAAVIDRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDR8</accession>
    <name>F4FDR8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RNA polymerase, sigma-24 subunit, ECF subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_12425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12425"/>
    <dbReference type="EnsemblBacteria" id="AEB43599">
        <property type="protein sequence ID" value="AEB43599"/>
        <property type="gene ID" value="VAB18032_12425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12425"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_0_11"/>
    <dbReference type="OMA" id="MLHELMP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="440" mass="48072" checksum="B16212B0C05E7FEC" modified="2011-06-28" version="1">MNDGEQPAPFEGAEPPRAVGVRFAQPDPAERTNPAERALVDAHRREWAFVVAATARAAGDLDLAEECVQEAYVAALGAWTRDGVPDKPGAWLTAIARRRALDVLRRRQVLRTKLPLLVEPEAVEADESDEVAVPDDRLRLVFTCCHPALAREAQVALTLRLVCGVSTADIARAFLVAESTMAARVTRAKKKISAARIPYRVPDTAELPERLDAVLSVVHLLFTTGHTAPTGVDLVRADLVDRAVHLARMLHELMPDEPEVSGLLALLLLTDARRATRTDEQGRLLRLEDQDRSCWDRTAIGEGHRLVVEALRTGRAGRYALQAAIASLHAHAPSYAATDWPQIVRLYDALLAHWPSPVVALSRAVAVSMVDGPAAALAEVDALAADPRLAGYHYLPAIRADLLRQLDRRSEAAQAYRAALAQVDNDPERDFLTTRLTEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE14</accession>
    <name>F4FE14_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-associated protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_18905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733538.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18905"/>
    <dbReference type="EnsemblBacteria" id="AEB44883">
        <property type="protein sequence ID" value="AEB44883"/>
        <property type="gene ID" value="VAB18032_18905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18905"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_2_1_11"/>
    <dbReference type="OMA" id="AWAVTYQ"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309289" evidence="4">
        <location>
            <begin position="29"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="197" mass="20618" checksum="8722929033717CCF" modified="2011-06-28" version="1">MTATLGALAWLAVVVLFGAVVPVVPTGAAVSGAAALAAHQDPVTVLLVVLAGAIGAYVGDLAVYLAMCWGGERFARRLRWLRGPNRLDRVSARVREGGVTMFLVSRLIPGGRLPVLLAAAVSGLPWRRFAVANLPASLLWSALYAAIGVLGRAIFPEPWQSVVAAILIVLLISQALGWWGRRRPLSVPPPASPAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE98</accession>
    <name>F4FE98_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46164">
        <property type="protein sequence ID" value="AEB46164"/>
        <property type="gene ID" value="VAB18032_25330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25330"/>
    <dbReference type="HOGENOM" id="CLU_3349989_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="37" mass="4192" checksum="46E22A4D0BA14F51" modified="2011-06-28" version="1">MTSQQTQRVVLNLQDWRGDLKVGETEKVGSAWLSNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEC7</accession>
    <name>F4FEC7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46193">
        <property type="protein sequence ID" value="AEB46193"/>
        <property type="gene ID" value="VAB18032_25475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25475"/>
    <dbReference type="eggNOG" id="ENOG50330A6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868242_0_0_11"/>
    <dbReference type="OMA" id="FQHCDAL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="37592" checksum="A6E6C5DDECB6B9A3" modified="2011-06-28" version="1">MPLPQATWAAETGGDVRVDGIAGWVGSAPLRGLVAHFGGRWPHGDLGAVLAGLDAFSARCWDFRAGRERPEAREPNLDPATVELVYRCADALGLVRARPPARSRYAHLVVLGGLAHACLRRVAYAGHLLRTGMDVAGEVAVLGSFRQLSEVERRTLAEVGVTGCDTEVDALDAAVRRTFAVSEPETEDGLDADHPHHSWSSRTYRPAGQPPVRVLAAPSSEPERRRAHTADTQRFWAEHAQLARADEVLLVTAPIYVPFQHCDALRTLALPYACEVETVGVDPMLPDLNRLPEPTLTPGRYLQEIRSAIRSLRALHTAVGTPPATAQSGLHRVRAGRGGTGTAQPSSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEF2</accession>
    <name>F4FEF2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734870.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25600"/>
    <dbReference type="EnsemblBacteria" id="AEB46218">
        <property type="protein sequence ID" value="AEB46218"/>
        <property type="gene ID" value="VAB18032_25600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25600"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_2_0_11"/>
    <dbReference type="OMA" id="LIMQERD"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="439" mass="47226" checksum="E9D26F7EAF2D63EF" modified="2011-06-28" version="1">MSLRPETTRQVDAVVADAQAAGHVPSLILGVVRDGTLAHVTAAGSNPAPDADLQFRIGSITKTMTAVLIMQERDAGRLALDDPLRRHLPEADAAGPVTLRQLLGHISGLQREPDGPWWERNAGVDLPTLLAGFSAAKIAYPPHRTFHYSNLAYGLLGGALERITKTPWAQLLSERILDPLGMNRTTYAATAPFAPGYVVHPWHDTLREEPRADTGAMAPAGQLWSTVADLARWAAFLAEPDPAVLAPETVDEMCVPMAMIDPDSWRAGPGLGLALHREGERVYTGHGGSMPGYLAVLEVHRPSRTGVVGFTNAYSFRSGGLGTLGRQLLTQVLDAEPMPARPWRPVDAPPPADVAALTGRWWWMGLPLDVTWDAATGELLGTMPGDPVSHFVPQGPDRWRAVRGEENGEVLAVLRDDNGTPVALDIATFVFTRSPDDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEG8</accession>
    <name>F4FEG8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736045.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01630"/>
    <dbReference type="EnsemblBacteria" id="AEB47410">
        <property type="protein sequence ID" value="AEB47410"/>
        <property type="gene ID" value="VAB18032_01630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01630"/>
    <dbReference type="eggNOG" id="ENOG503306W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908018_0_0_11"/>
    <dbReference type="OMA" id="LRVCFSQ"/>
    <dbReference type="OrthoDB" id="1869278at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="33814" checksum="22877FCCC18D8578" modified="2011-06-28" version="1">MRKSSSRSPFGWSNRGGTVTVIEAPIARSYRRRAVIAFWVTSTVIGLLAATVASHYLHPILGALAGVLLGVVLGAVVFVLIVAWPVLRVFWHWLPEILLGLAVVYGWVALMQATPLWLSLLVVALVVGMPAGIGPVRRRIVAWSWCLIVRHRLRLCFAAFIATNRHGSLPLILLARPTPAGERVWVWLRPGLSLRDLEADGQVQKLAVACWANEVRVMRASRKYAALVRVDVTRREPLAHTIVSPLPDYVPVDIPSNAPTSPGMPPVGLDLPDVPDHPATVPADPPRPRKPRNPSTTDASPSGFDPSDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF03</accession>
    <name>F4FF03_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13005"/>
    <dbReference type="EnsemblBacteria" id="AEB43715">
        <property type="protein sequence ID" value="AEB43715"/>
        <property type="gene ID" value="VAB18032_13005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13005"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_0_2_11"/>
    <dbReference type="OMA" id="DNLTFRM"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="42071" checksum="4B2A07A533441809" modified="2011-06-28" version="1">MARVLFRSWEQAPAAHDDAWAGSGVARVADHVGVEHLLVTRHALVRQVLTDPHTYRPDNALDAVTPMPVSALRILAAHRFRLPPTLANNGDASHPGIRALVADALHPKRVAEQQDWLTALVRRRVAGLTAELDAGRPVDLYAGLAADLPLLVLARLVELPDAPVTAVKSFARAALELFWAPLDAARQQQLAAEVGRFHLVLREFAATGGGLAGALRAAGHPPDVVVGALFFLLVAGQETTSQFLTLLMHRLVGEPGVLAGLRDGSVAVADVVEEGLRLEPPIVTWRRVAAVDTTLGGTAVSAGTSVVLWLAGAGRDPAVVESPDEFRPGQRGSRRHLAFGAGVHRCVGDQLARMEAATVVAEAAPLLAEVRVLRAPWYPDNLTFRMPDTFLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF56</accession>
    <name>F4FF56_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733616.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19295"/>
    <dbReference type="EnsemblBacteria" id="AEB44961">
        <property type="protein sequence ID" value="AEB44961"/>
        <property type="gene ID" value="VAB18032_19295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19295"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122305_0_0_11"/>
    <dbReference type="OMA" id="KHYAEEK"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="162" mass="17315" checksum="ECA29066F0838983" modified="2011-06-28" version="1">MSELTVRSMTEAEFDRWRAGIVRAFADAQVAAGNWPAEEAQELAQQGNDALLPAGFGTPGMLFLTGELRDGTPIGVLWIGLTHPRGVPDCAFLYDIEIGADHRGAGYGRALLAAGEDAVRRHGVGAIELNVFGDNARAVGLYGSSGYRVVTQQMRKTLVAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF71</accession>
    <name>F4FF71_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_19370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733631.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19370"/>
    <dbReference type="EnsemblBacteria" id="AEB44976">
        <property type="protein sequence ID" value="AEB44976"/>
        <property type="gene ID" value="VAB18032_19370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19370"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="MSSLNPC"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="328" mass="34413" checksum="76AD6F765E29F73E" modified="2011-06-28" version="1">MSDAVLAVSGLTVTIGTRRGPARAVAGVDWSVQAGQTLALVGESGSGKSMSVLAATGLAPRAARVTGGVRLLGEDFTALPADRRRRMRGRHVGFVFQDPMTSLNPVLTVGRQVAEAGEEHLGLTRRAARTRAIELLDLVGIPSAAQRVDAYPHQFSGGMRQRVVIAMALACEPDLLIADEPTTALDVTTQAQIVELVADLQQRLGTAVVWITHDLGVVAGIADTVAVMYAGRIVEQGPVDAVFDRPGHPYTSALLAARPEPGAGGGDLVTIAGAPPSPHELPAGCAFWPRCPVRGDARCEHELPPLVPVAGAHHVRTFYPQQPDGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFF8</accession>
    <name>F4FFF8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25810"/>
    <dbReference type="EnsemblBacteria" id="AEB46260">
        <property type="protein sequence ID" value="AEB46260"/>
        <property type="gene ID" value="VAB18032_25810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25810"/>
    <dbReference type="eggNOG" id="ENOG5033TNK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943086_0_0_11"/>
    <dbReference type="OMA" id="MAREWDW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="33266" checksum="3AE3A1D55A54A311" modified="2011-06-28" version="1">MTPLTETPPSIGGDQMSVAAEQGRICALAAKGQRDLAKVAAAYPELFPAKPFDATLFGNVAMAIAFGAPWCDVAQLRLTNRAVLWGFAVDWLVDHEARARDEIDRLTARCLAVADGATPEPGDALGGFLAELRDELATVPAFAAHRDRWREETRKVLAAMAREWDWKQNPDQLPSFEEYLDNADNLACTVVNVVHWIHTADPATLTHLDAMLAASDRVQRILRLVNDLGTYERDLRWGDLNALLLVPRTEVEQRIAELVAQARQLLDGLRENCPVQADYLARQIGFSSGFYRSTDFWGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFI0</accession>
    <name>F4FFI0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_25920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734933.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25920"/>
    <dbReference type="EnsemblBacteria" id="AEB46282">
        <property type="protein sequence ID" value="AEB46282"/>
        <property type="gene ID" value="VAB18032_25920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25920"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_11"/>
    <dbReference type="OMA" id="PVCLRYG"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="41"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="434" mass="46944" checksum="3F7C06389F6FB1A7" modified="2011-06-28" version="1">MTTIAIPPGMPQYDDVPRYDVAAVRADFPILGREINGHPLVYLDSANTSHKPRQVLDVLREHYEQHNANVSRSVHTLGTEATEGYETARAKVAGFINAPSVDEVVFTKNSTEAINIVAYAFSNASLRADADPRFRLGPGDEIVISEMEHHSNIVPWQLLAERTGATLRWFPVTEQGRLDESGLTDLVTERTKIVSLVHMSNILGTVNATARITERVREVGALLLWDCSQSVPHMPIDVVDLDADFIVFTGHKMCGPTGIGVLWGRSELLAAMPPVLGGGSMIETVTLAGSTFAAPPARFEAGTPPIAEAVALGAAVDYLTALDMRAIQWHEKQLTAYALDALGSVPGLRIFGPEVPVGRGGTISFALGDVHPHDVGQVLDSLGVQVRVGHHCARPVCTRFGVPAMTRASFYLYTTTEEIDALVAGLEQVRKVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFJ6</accession>
    <name>F4FFJ6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="3" type="ordered locus">VAB18032_26000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734949.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26000"/>
    <dbReference type="EnsemblBacteria" id="AEB46298">
        <property type="protein sequence ID" value="AEB46298"/>
        <property type="gene ID" value="VAB18032_26000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26000"/>
    <dbReference type="eggNOG" id="ENOG5032TBE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134276_1_0_11"/>
    <dbReference type="OMA" id="CANGHET"/>
    <dbReference type="OrthoDB" id="1928204at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="114" mass="12650" checksum="7460D5B616F43CEB" modified="2011-06-28" version="1">MSNGNVIRGARVGSAPPRHPERHRPVPCRSVSFWCRNGHRTDIRIAADAATPELWDCPRCGLPAGPDAQDPPGRVRAEPYKTHLAYVKERRTDAEGEAILAEALAALRHRRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFS3</accession>
    <name>F4FFS3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine kinase HAMP region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736183.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02330"/>
    <dbReference type="EnsemblBacteria" id="AEB47550">
        <property type="protein sequence ID" value="AEB47550"/>
        <property type="gene ID" value="VAB18032_02330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02330"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008825_0_0_11"/>
    <dbReference type="OMA" id="QAEWNTP"/>
    <dbReference type="OrthoDB" id="811938at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="321"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="618"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="691"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="755"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="840" mass="89676" checksum="51EF974FA16F98FD" modified="2011-06-28" version="1">MLLDRLRIRGKLALLVLVPVLCMLGLTLPVVWERVGVAQRADDIAGTVQVANRVGTLLQHLQRERMLAVGLLLRQADRSDLVQEIAKVDDLVADLRAELGDDLTPAVTAALDGVRQLAPVRTALLANHATVDQILGTYAPVHLALIDSLRLPYDVDTRTSVGRQVLALDRILRKSEGISAGAALIVLIAADPNPALATAFVANMATLRADSNQMLGLLTPEQLVLMDIEQAAVDARAGEDFLEQSALDPVTAASRIPIEALYPTTSSLITLGQFVEKKLVTDVTAEVRAERQAALSAAYWVTALVLVILLVVGLLALVIGRAVARPLTRLTRSADRVARVAESELLRVADDEADQAQSIRLDRVEIRGRDEIGDLARAFERVQTTAAQLVERQVASRRNVAQMFGHVGRRTQNLVGRQIALIDRLEQQETEPGRLENLYRLDHISSRLRRNAGNLVVLSGAAGDVVHAAPVPLADVVRLALGEIEDYTRVDVQVPGEVSAAPAIVGDLVLALAELMENATVFSPPHTRVVVNGELTEDGARLTVVDHGIGMTEARLADENARLTRRERLDLVPTEVLGLFVVGRLARRHGWRVVLSATPGGGVSATLSIARPDLVLGTPEPDLRTTPITVRPALPTPSQPVPASPARPGDGLAAAGTGGPGGFDQRLLTRATASIELAESWDAFATAARVEADPAVTQQTPVPPAPPGATTPPPGIRQRVPGASLPRITPRVGPADATTADPAAARTLVEQFESGVRRAEQQRGHAHPEPVAPAPSGAPAHLTRRVPGANLVTTPNRQQLTDHPGDPAEVRDLINAFENGVARALRDVRPDRSNDEGTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG07</accession>
    <name>F4FG07_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731260.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07315"/>
    <dbReference type="EnsemblBacteria" id="AEB42587">
        <property type="protein sequence ID" value="AEB42587"/>
        <property type="gene ID" value="VAB18032_07315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07315"/>
    <dbReference type="eggNOG" id="COG3178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918020_0_0_11"/>
    <dbReference type="OMA" id="EPFGWVH"/>
    <dbReference type="OrthoDB" id="1355603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="56"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="35094" checksum="F548F1973AED16F3" modified="2011-06-28" version="1">MNAPRLDERLVAQLRCDLLTAARRVPAGRQAIQEWELSAVERLFFADGSSVICKVAARPFTGEATVLRALNEQGASVPVLHGYAMRPQTLGMLMDDLGEPVRAATVAEAAAAARRIHAATGITGLPTFDQAGLARLPGQALDALTALRRRERFPDSGPIEELLQRLTAVAQRRADGAERPPFGLCHGEFHRSSLHVTRTGCRLVDWAKAFTGPGLLDLATWFGTRTPPQPRLLTRLIRAYIAAGGHPDAEADRGGLPAARWALGWHRVWAAWWLLTTAAGHHRPDTDRHHVQVVLRQLHGAAQLLGATQPTSTARPSLEAGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGD0</accession>
    <name>F4FGD0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733723.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19830"/>
    <dbReference type="EnsemblBacteria" id="AEB45068">
        <property type="protein sequence ID" value="AEB45068"/>
        <property type="gene ID" value="VAB18032_19830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19830"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092418_0_0_11"/>
    <dbReference type="OMA" id="TWDLRPW"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="57"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="207" mass="21987" checksum="61DD24BB86822AF7" modified="2011-06-28" version="1">MSERSAAPGSPTRWATDTGPEHSQWYVDRFRQLAAEGADLAGEARLVDALVPPRSRILDAGCGTGRVGAELAARGHTVVGVDADPVLVEAARTDHPGPRWLVADLTTLDLATAGEPEPFDAAVLAGNVMTFVAAGTEVAVLRQVAAHVRPDGVIAIGFGTDRGYPLADFDAHVAAAGLRRDHRFATWDLRPWHDDADFAVTVLRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGI3</accession>
    <name>F4FGI3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="6" type="ordered locus">VAB18032_26100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734969.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26100"/>
    <dbReference type="EnsemblBacteria" id="AEB46318">
        <property type="protein sequence ID" value="AEB46318"/>
        <property type="gene ID" value="VAB18032_26100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26100"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_0_1_11"/>
    <dbReference type="OMA" id="RFHDCAH"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="105"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="111"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="202"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="35602" checksum="8837E4BD510D9A76" modified="2011-06-28" version="1">MDITLTALGWDTDRAAHLSRIHTDHRPGRVARVDRGVCTVLTSDGPVRASCGGALLAAAVGDATRLPGAGDWVLLGTWPDARVTVEAVLPRRTALIRRTAGKDASGQLLAANLDTAAVVEPVHPEPNAARIERLLSLVHESGARPLVVLTKTDLTADPAAVARQLAALAPGVPVLPVSAETGTGLDPLRAEVAPGRTLGLLGPSGAGKSSLVNALVGAVVMPTQSIRRVDGKGRHTTTWRALVPLPGGGAVLDTPGVRAVGLLDGESGLDRAFGDIADLATGCRYGDCGHEAEPGCAVQAALASGDLSTRRWQSWRRLHRELTHETRRHTTRPTRPRHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGY2</accession>
    <name>F4FGY2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_07370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731269.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07370"/>
    <dbReference type="EnsemblBacteria" id="AEB42596">
        <property type="protein sequence ID" value="AEB42596"/>
        <property type="gene ID" value="VAB18032_07370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07370"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="TIMGLWQ"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="243" mass="25725" checksum="71A92BE703F402B3" modified="2011-06-28" version="1">MLHIRDLTVAYPHGAPVLHDLTLDLRHPGVHALVGPNGAGKTTLLHTLAGHLHPRAGTIHLDGEDVTGWHPTTAARAAVALAPQGRRLWPSLTVAEHFAATQPTAGRDEAWTVEELLTMFPPLAARMGHRAHQLSGGEQQMLTIARALRTAPRLLLADEPTEGLAPTVADQITTVLQGLPARGVTVLAALPHTDVAATIADTIHVLAAGKLLGHTHTSTAASHLLRRHLTLTDPGDETATPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGZ2</accession>
    <name>F4FGZ2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731279.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07420"/>
    <dbReference type="EnsemblBacteria" id="AEB42606">
        <property type="protein sequence ID" value="AEB42606"/>
        <property type="gene ID" value="VAB18032_07420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07420"/>
    <dbReference type="eggNOG" id="ENOG5033NYU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178607_3_1_11"/>
    <dbReference type="OMA" id="RGAYPCK"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="94" mass="10002" checksum="FFF2989D3C664D9E" modified="2011-06-28" version="1">MRSGRTRRARVAPAGAPQAWTVEQIRALGTSTDLATAASVLGMSRSAAYKLIRRDAFPVPHFRVGARYRIPTAPLLAALHLPGTPTAQNSEPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH32</accession>
    <name>F4FH32_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731319.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07630"/>
    <dbReference type="EnsemblBacteria" id="AEB42646">
        <property type="protein sequence ID" value="AEB42646"/>
        <property type="gene ID" value="VAB18032_07630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07630"/>
    <dbReference type="eggNOG" id="ENOG5033KBD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094847_1_0_11"/>
    <dbReference type="OMA" id="WAVTHVL"/>
    <dbReference type="OrthoDB" id="1986919at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025358">
        <property type="entry name" value="DUF4262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14081">
        <property type="entry name" value="DUF4262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="17255" checksum="C70D0329D0D7A37B" modified="2011-06-28" version="1">MPDIDDFLRNQERIITTRGWAVTHVLPTDDDPDTTAPFAYTVGLTAHDHPELIIAGLPPLVAHTLLNDLARQVYDKAERFSHGQRISDLIAGYDAVIIDGRPTDDLLPGAAIARYGRLRIRLQQIVWPDQQGRFPWDSGYNFDPHIQPMIAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH41</accession>
    <name>F4FH41_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731328.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07675"/>
    <dbReference type="EnsemblBacteria" id="AEB42655">
        <property type="protein sequence ID" value="AEB42655"/>
        <property type="gene ID" value="VAB18032_07675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07675"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_5_0_11"/>
    <dbReference type="OMA" id="QRDGTWD"/>
    <dbReference type="OrthoDB" id="2020052at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="102"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="34181" checksum="6486DEB5B5385481" modified="2011-06-28" version="1">MATIAVTRRHDLTDAQWRVLESLLPAGKRPGRPSQWSKRQLIDGIRWRVRVGAPWRDVPACYGSWQAIYALFRRWQRAGVWQHIVTELQARADAAGLITWDVSVDSTIARAHQHAAGARRRPHQQIEPPGGVGTEPGDHALGRSRGGWTTKLHLACEQGGKPLSMLLTAGHRGDSPQFTAVLAGIRVPRPGVGRPRVRPDRVIADRAYTFRANRTYLRRRGIRACIPSKVDQDAHRRAKGSAGGRPPAFDPEVYRQRHAVECGINRLKRHRGLATRYEKLAVRYEATIHVTVINEWLHALRDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI68</accession>
    <name>F4FI68_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713154.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30344"/>
    <dbReference type="EnsemblBacteria" id="AEB48032">
        <property type="protein sequence ID" value="AEB48032"/>
        <property type="gene ID" value="VAB18032_30344"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30344"/>
    <dbReference type="eggNOG" id="ENOG5032YIM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142117_0_0_11"/>
    <dbReference type="OMA" id="ALWLAWE"/>
    <dbReference type="OrthoDB" id="1635062at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032584">
        <property type="entry name" value="DUF4913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16259">
        <property type="entry name" value="DUF4913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="17808" checksum="2BE9D9F68EA443FA" modified="2011-06-28" version="1">MTTPATDPAAEAIADLSALLGQLAGDPAPPAPEPPADEQAAAEPVYRNVEAFVGDYLAHVVERRLASGPDSGLNWCPRWWAHPEAISRLYALWRAWETLRVSDPQTGMSIWWRDHLDPHLAALTAEYGPFNRCSPNKHTEPRPLPVKPAPPEVLAQLPDADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1J2</accession>
    <name>F4F1J2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20605"/>
    <dbReference type="EnsemblBacteria" id="AEB45221">
        <property type="protein sequence ID" value="AEB45221"/>
        <property type="gene ID" value="VAB18032_20605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20605"/>
    <dbReference type="eggNOG" id="COG3473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068086_4_0_11"/>
    <dbReference type="OMA" id="SPYEPWL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="27570" checksum="7293E87B1EB510AB" modified="2011-06-28" version="1">MWVMEKALGIIVPPANPTVEPELRRLLPLRVRYHVARLPVVDGPLAQRLDRYAELLPETAATLQGLDLAATYVACTGCYYRPGHTDAHRTDDAATQRLGSPVFGAASAVRQLLDRLGVRSLTLVSPYPDWLTEQAAAFWRTTGRTVGAPVRVPGTGAIYDLTSTTVRDTVRQVLQAGGFPPGHAVLLTGTGAPSLDVLDEVLPTAPVPVLSSNLAGAWQLLETAGATDLAGESPSAALRQLAAVVAHTSMTGVVGDIAGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1M0</accession>
    <name>F4F1M0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733903.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20745"/>
    <dbReference type="EnsemblBacteria" id="AEB45249">
        <property type="protein sequence ID" value="AEB45249"/>
        <property type="gene ID" value="VAB18032_20745"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG3393">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
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    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="126"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="27656" checksum="48300B424A2C0E89" modified="2011-06-28" version="1">MPVRAEHDRSVLAGLLGRDPQLHAYELGDLDDFFWPYTSWYRRGGSVALLYHGMRPPTLLALTRPEGVEELAALVGELAPVLPARLWAHLSPGVEVGLAGAFRVVSAGAHLKMALTRPDRLAAVAAAGEVLGREHVPALRELYAVAYPGNWFDARMVDTGRYVGVWAGGVLVAVAGVHVYSPAFGVAALGNVTTHPAWRGRGLASAVVARLCGLLRAEVEQVTLNVKADNGVAVRLYERLGFRRSAQYGEFDLAAVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F243</accession>
    <name>F4F243_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731405.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08070"/>
    <dbReference type="EnsemblBacteria" id="AEB42732">
        <property type="protein sequence ID" value="AEB42732"/>
        <property type="gene ID" value="VAB18032_08070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08070"/>
    <dbReference type="eggNOG" id="ENOG5034977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1493153_0_0_11"/>
    <dbReference type="OMA" id="WAYVQEL"/>
    <dbReference type="OrthoDB" id="1663384at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="22169" checksum="40E2BE9960AFD0EA" modified="2011-06-28" version="1">MTTDTAPRVDGASQADGTGTWAVLLPAGRYDAERLVHHDTLELTGLADVAALPRVGDQVAVLADEPLRLVAVGRVAAPTSWLPEDPDDPQSDRGPQALVVTYTRRAFDEPVPADTLALGGPVTALDAGAFRDLVERLGPPPQRQSWLVSLDLPIEADSPAEAVRLFWAYVQELGPQELPAFVSPSGDELSMQAFVLGAEANQDPEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2A6</accession>
    <name>F4F2A6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_08385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731466.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08385"/>
    <dbReference type="EnsemblBacteria" id="AEB42795">
        <property type="protein sequence ID" value="AEB42795"/>
        <property type="gene ID" value="VAB18032_08385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08385"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_11"/>
    <dbReference type="OMA" id="VMIQLVQ"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="307" mass="33185" checksum="4F5B8201B341C4AA" modified="2011-06-28" version="1">MTATFLRKSPGTRPRRPPWEEPPSPLGQGAKAVLLSLLVLSVLFPLWVILVTSLSSRETIARAGGLVVVPRGIDTSAYETIFAGGAVTRALWISTLVTVIGTALALTVTVLAAYGLSRPRSLGYRWLLAYFLLPFLIYPPLVPKYLVVTGLGLKDTIWALILPPAISVFNLVVVRGFFQGIPSELVDSARIDGASDFRTLTQIVLPLARAVIAVVGLFYAVSYWNVWFDALLFIDRNDMYPIQRVLQSYLLAGQAPNTSGAAVGATMPPTEAIKMAVVVLTVAPIVAVYPFIQRHFVKGVLIGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2D5</accession>
    <name>F4F2D5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14475"/>
    <dbReference type="EnsemblBacteria" id="AEB44007">
        <property type="protein sequence ID" value="AEB44007"/>
        <property type="gene ID" value="VAB18032_14475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14475"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_11"/>
    <dbReference type="OMA" id="WQQSYGD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="23435" checksum="82013FF667CD8A06" modified="2011-06-28" version="1">MLRSLTDRGHAVHAVGTALDALRRVAAEAPDLVVLDLGLPDLDGSDALRMLRGITDVPIIIATARDDEQSVVKLLRAGADDYMVKPFTGAHLDARITSVLRRVGRASRAEQPVVLSVGGLRVDLGERSAQLDGESLALTRKEFDLLAYLAARPGRVVSRRELLEEVWRQPSVGEDQTIDVHLYWLRRKMGESAAKPRYLRTVRGVGFRLVAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2D9</accession>
    <name>F4F2D9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">thrS</name>
        <name evidence="13" type="ordered locus">VAB18032_14495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732678.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14495"/>
    <dbReference type="EnsemblBacteria" id="AEB44011">
        <property type="protein sequence ID" value="AEB44011"/>
        <property type="gene ID" value="VAB18032_14495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14495"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_3_1_11"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="294"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB44011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="666" mass="74222" checksum="5F4C191E4CB4C2BC" modified="2011-06-28" version="1">MSAPRTPAVADPVVVAAGTTAADAVAAAELPTSGPKAIVVVRDPQGVLRDLDWRPAEETVVEPVALDSPDGLNVLRHSTAHVLAQAVQDIFPEAKLGIGPPIENGFYYDFAVDKPFQPDDLAKLEKRMQEIIKSGQRFRRRRFDSLDEAKVELAAEPFKLELIDVKGEGLDSSEVMEVGGGELTIYDNLAATEDKVCWSDLCRGPHLPNTRLIGAFKLMRSAAAYWRGSERNPQLQRVYGTAWPTRDELKAYLKLLEEAARRDHRKLGVDLDLFSFPDELGSGLAVFHPKGGIIRREMENYSRLKHEQAGYEFVNTPHITKGHLYEVSGHLDWYADGMFPPMEVEGASYYLKPMNCPMHDLIFRSRGRSYRELPLRMFEFGTVYRYEKSGVVHGLTRVRGMTQDDAHIFCTEEQMAGELKSLLAFVLELLRDYGLDDFYLELSTRNPEKSVGTDENWERATEALRSAAEESGLTLVPDPGGAAFYGPKISVQVKDAIGRTWQMSTIQVDFNLPERFNLEYQAADGTRQRPVMIHRALFGSIERFFGVLTEHYAGAFPAWLAPVQVVGIPIRDDHADYLHGFVAALRAEGIRAQVDSGDERMQKKIRNAQQQKIPFMVIAGDDDVAAGTVSFRYRDGSQRNGVPLAEAVTHVLDVVNTRTNVGPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2M2</accession>
    <name>F4F2M2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20935"/>
    <dbReference type="EnsemblBacteria" id="AEB45287">
        <property type="protein sequence ID" value="AEB45287"/>
        <property type="gene ID" value="VAB18032_20935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20935"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_5_0_11"/>
    <dbReference type="OMA" id="GEWAVRI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="370" mass="40291" checksum="86ED94D55C66689F" modified="2011-06-28" version="1">MIGGGPAGLSAAFAAARRGVRTLVLERAAHPRYKTCGGGLTGISFAAVATRIDVPVHDAVDEVTFTLDGRRSFTRRHRPGALVRMVRRDEFDDRLRAAAVAAGAEVRERVTVRAVDQTPDGVRLRLADDATVLARTVVGADGSSGVSARHVGVRYRQVDLGLELELPVSPQQQARWRRRMLLDWGPLPGSYAWVFPKADRLSVGVIAGRGDGERTREYLRRFVDRLGLAGVSPVHDTGHLTRCRAEDSPLRRGRVLVAGDAAGLLEPWSREGISFALRSGELAGEAVAAADLTGYESAVQQRLMPAIRAGHRLREVFAQRPEFFHLALGTPPGWRAFTRFCLGRSDFGQLVEALPVRTALALAARLPHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2N6</accession>
    <name>F4F2N6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733955.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21005"/>
    <dbReference type="EnsemblBacteria" id="AEB45301">
        <property type="protein sequence ID" value="AEB45301"/>
        <property type="gene ID" value="VAB18032_21005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21005"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_4_2_11"/>
    <dbReference type="OMA" id="ARNQIEV"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="191" mass="20740" checksum="A863887181BE5F9D" modified="2011-06-28" version="1">MSGPHGDDIHTDPITDDFGWMLGVLFRAHLRGAEHTVGDLPGGPRGYQVLVAADREPARNQGAIAEELGIDRTVLTYLIDDLERDGLLSRRPDPADRRSRLVVVTDAGRAAARQRREALRDVETRLMAALTDEEAATLRALLRRAACAAQAADPLTDLCAVAEVVADPPPSRRRPATRATRSGTPRRTAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Q9</accession>
    <name>F4F2Q9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lantibiotic biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21120"/>
    <dbReference type="EnsemblBacteria" id="AEB45324">
        <property type="protein sequence ID" value="AEB45324"/>
        <property type="gene ID" value="VAB18032_21120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21120"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073591_0_0_11"/>
    <dbReference type="OMA" id="TWKENSI"/>
    <dbReference type="OrthoDB" id="1435011at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="1">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="356" mass="40324" checksum="537C69140DFA8E16" modified="2011-06-28" version="1">MSEGEWTVTDYPSPVDHGWLSVHVFYASNANPMLVEGVRPLVDELREEGLISRYFFIKYWMEGPHVRLRVLPAPGVDPQVVRSRVDEAIAAFLRRRPALYEVDSEGLGDLYKQMFLAEYGQQRWDAEYGATGRMPMRANNSYHHIPYEREYGRYGGPAGIELAEWHFEHSSDVVLDLLATTNVHVRPVLLGLSAQLGMMLCAVFLDDDRRIAEFLDEYRRFWEVSYSEPSDDYHASFDTSYRRMDAALRDRLAAIRTAARGPASAQATGVEGRWAAHCRELRDRVVAAAGQGKLVFQRGDAEPRVVEDLDAVVPIVLSSYLHMTNNRLGVSILDEIYLSYLMRAALLDEPAPAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2W3</accession>
    <name>F4F2W3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U61 LD-carboxypeptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_27506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27506"/>
    <dbReference type="MEROPS" id="S66.001"/>
    <dbReference type="EnsemblBacteria" id="AEB46574">
        <property type="protein sequence ID" value="AEB46574"/>
        <property type="gene ID" value="VAB18032_27506"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27506"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_3_1_11"/>
    <dbReference type="OMA" id="MLTQWRL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="187"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="313" mass="32607" checksum="72E0DD5F917DF2A3" modified="2011-06-28" version="1">MSDHTAADHVVRPPALREGDTVMLVSPSGPTRPERVARGIELLTGWGLRPVLARNVYARQGYLAGVDALRAADLNAAFADPQVRGVICTRGGYGAQRVVDAIDMAAVRRDPKVVAGFSDITALQLALWRGARLAGVHGPGAAWRDERTPLASAESLHAALTRTEPVTVRAVEAEETFAVRVPGRAVGRLLGGNLCLIVASLGTPDMPDLTGAVLLLEDVQEPPYKVDRMLTQLRRAGALDGLAGVAVGQFTDCADGWEVSVADVLTERLGDLGVPVLGGLPIGHGPGQLSVPVGTLATLDADAGTLTVAPAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F383</accession>
    <name>F4F383_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_03900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736494.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03900"/>
    <dbReference type="EnsemblBacteria" id="AEB47862">
        <property type="protein sequence ID" value="AEB47862"/>
        <property type="gene ID" value="VAB18032_03900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03900"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_11"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="19137" checksum="67CA479F993AEAD0" modified="2011-06-28" version="1">MAEAVYATLHTNAGPIRLELFPNHAPKTVRNFVELAEGTREYTDPRTGQPGSGPYYDGTISHRVISGFMIQMGDPTGTGRGGPGYNFADEFHPELRFDRPYLLAMANAGPGTNGSQFFITVAPTPHLNNRHTIFGQVADEQSAKVVDSIANTPTGPSDRPLQDVVIERVEIERQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3M8</accession>
    <name>F4F3M8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_15120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732801.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15120"/>
    <dbReference type="EnsemblBacteria" id="AEB44136">
        <property type="protein sequence ID" value="AEB44136"/>
        <property type="gene ID" value="VAB18032_15120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15120"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014629_4_0_11"/>
    <dbReference type="OMA" id="GRRFFTM"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="PTHR10909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="56"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="135"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="278"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="ACOX" evidence="7">
        <location>
            <begin position="499"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB44136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="663" mass="71850" checksum="4BBFF84626419EAC" modified="2011-06-28" version="1">MSSQPSVPVDVARLREVLDGPWAEVREAHRTELDDSFLPVYGETGDQARERITGLLPRLPVTMGMPAAFPAEYGGRSDIGASIVATEMLAQVDLSLMVKAGVQWGLFGGAVLSLGTGRHHDAYLRDIVAGDILGCFAMTETGHGSDVQQLRTTCTYDPATQTFDLHTPHQAARKDYIGNAARDGRMAVVFAQLITNGQRHGVHAWLVPIRDAQGNPMPGVTIGDAGPKAGLLGVDNGRLSFDHVTVPRDMLLDRYGQVAADGTYSSPISNDSRRFFTMLGTLVRGRASVGGAAAAATKVALTVAVRYGDIRRQFSSPDAEREVLLNDYLAHQRKLLPALATTYALHFAQAELVAAIDQVQGGDGPVDEHRQRELESRAAGLKAAQTWHATRTIQMCREACGGAGYLAENRLPGLKADTDVFTTFEGDNTVLLQLVAKGLLTGYRDEFGSLDGWGRASFVAEQVREMVLERTAARSLIERLVSAVPGRDEEVAVTDRGWQLKAFEDRERHLLDGAVRRLRNGASTKKDRPFDIFNDVQDHVLAVAAAHVDRVTLEAFVAGIEATSDPAVKALLSRVCDLYALSVIEAHKGWFLEHGRLTPARAKVITAVVNNLLKELRPQMGTLVDGFGIPQSWLHCAILREEADRQEAMAAHDAAGDPQTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3S0</accession>
    <name>F4F3S0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21355"/>
    <dbReference type="EnsemblBacteria" id="AEB45371">
        <property type="protein sequence ID" value="AEB45371"/>
        <property type="gene ID" value="VAB18032_21355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21355"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OMA" id="HHVASMV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="397" mass="41756" checksum="8D1A4B2FA3AD704E" modified="2011-06-28" version="1">MTRVGWVGRLFDARDSFARMVLLDLAGLGYLIFGPLGGDRPGVTQWVLAVIAFSLGLVLHRRPLVNLVVQTALLAVAIPLLDDITINQVGASWALLELTMRAEATRTIWLTAAGLAAVALTDSIGEPLPRFLAGVVGLLLEVGVPLLLGLVVRTTRELTTQAQQRAAEEQRRRESEARAARADERSAIARELHDVVAHHVASMVLRVGVARHVITDLDPRVDAVFGDVHATGTAALADLRRLVAVLRDPDAVRGDAALTAIEPSALPAALGAAVDRARQAGITVEADIDPAIGAIDAVRGLAVLRLTQEALTNVARHAGPSAVARLTVRMRDGAVHWEVVDDGRGPVPAPVPAGGGHGIPGMRERVEVLGGRLAAGPVEGTGWRVQTVLPAVTEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3X0</accession>
    <name>F4F3X0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_21605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21605"/>
    <dbReference type="EnsemblBacteria" id="AEB45421">
        <property type="protein sequence ID" value="AEB45421"/>
        <property type="gene ID" value="VAB18032_21605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21605"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="GNFFVPY"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="266" mass="28584" checksum="F369B9196F568BB5" modified="2011-06-28" version="1">MLRTAAIWALICWSILPFAFMLRVGFAAPSDIRGGAPDWLAPLYVFNFVDLFGDAEFMGAIGRSILVAVVSSAIAIAAATPAAYACARMQFKGRSDFEFWVLSTRMLPAVVVVIPYFVLFRQIGGIDTVWALTVMHTVVNLAVTFFLLRSFFADLPAAVFEAADLDGCSETKKFMSVAWPMVRNGVAAAAVLNFIFSWNEFVFALTLASGEAKTVSVAMLGFMQFQSVAVGPMMAAGTLAVLPVAVVLFLAQKQLVTGMSFGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Y4</accession>
    <name>F4F3Y4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ordered locus">VAB18032_27786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735280.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27786"/>
    <dbReference type="EnsemblBacteria" id="AEB46630">
        <property type="protein sequence ID" value="AEB46630"/>
        <property type="gene ID" value="VAB18032_27786"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27786"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_4_1_11"/>
    <dbReference type="OMA" id="QFVFKNA"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="106"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="224"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="241"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="32595" checksum="C44D1D26956CB994" modified="2011-06-28" version="1">MSGSRILSLGHYQPSRVVTNNDIAQLVDTNDEWIRDRVGIVSRRIAGDETVADMAAAAADKALANSGLTAADIDLVVVATCTSVDRSPNVACRVAAKLGISAPGAFDVNTACSGFSYALGTVDHAIRAGASRNAIVIGAEKLSEFTDWTDRSTCIIFGDGAGAAVVTATGTDEAPGVGPVIWGSVPERGDAVRIEGWRPYVAQEGQTVFRWATTALAPLALQACERAGVDPSELAAFVPHQANTRIIDGIAKRLNIPQAIIAKDLVESGNTSAASIPLALSKLVERREVPSGAPVLLFGFGGGLTYAGQVVRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F405</accession>
    <name>F4F405_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_27891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735301.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27891"/>
    <dbReference type="EnsemblBacteria" id="AEB46651">
        <property type="protein sequence ID" value="AEB46651"/>
        <property type="gene ID" value="VAB18032_27891"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27891"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_1_1_11"/>
    <dbReference type="OMA" id="SGWGWYF"/>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="170"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="426" mass="47634" checksum="5F725631F4B3E337" modified="2011-06-28" version="1">MLDMELIRKDRDAVATALAKRLDAAEVDRALDEIQHLDRERRRLITEIDGERQRRKAEARAYAQAKRAGVEPQVTDETGRKQVAELEAELDQVQSRLRTVMSELPNLPADDVLPGGKEANRVVKTFGAPPAIEKIRDHVELSRMLALVDHERGVKLGGSGFWMYTGLGARLEWALINWLIERNIEAGYEFLLPPHLLLDTAGFAAGQFPKFYDDVYHLDKQSAPRGQFLLPTAETAILGAYQDEILDTASLPLKVFAYTPCYRREAAGSHSDERGTVRGHQFNKVEIFQFTLPEQADAALEQMVAHAESLVEGLGLHYQRSLLAAGDSSASMRKTLDIEVWMPSTGKYKEVSSVSWGGDYQARRAAIRYREPGGKQTRFVHTLNGSALATSRLLPAILEQFQQPDGSVLVPEVLRPRLGTDRLTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4B5</accession>
    <name>F4F4B5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736560.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47928">
        <property type="protein sequence ID" value="AEB47928"/>
        <property type="gene ID" value="VAB18032_04230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04230"/>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081840_1_0_11"/>
    <dbReference type="OMA" id="TRCHIGD"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="19329" checksum="98F268AA9B5F9FD7" modified="2011-06-28" version="1">MTTLRLRPEEPADTGAVRRVLAAAFARPDVATPPEVRLVEELRDGDAWLPELAMVAEYGGEIVGYALFTRVVVSADEHTAPALALGPVAVAPHRQRIGLGTSVVQAGLEAATELGERLVVVLGDPAYYRRFGFSRADRMGLTSPWSGLGEPWQALVLPPSTSGEPAPPQGEVVFPPPWSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4B6</accession>
    <name>F4F4B6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_04235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736561.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04235"/>
    <dbReference type="EnsemblBacteria" id="AEB47929">
        <property type="protein sequence ID" value="AEB47929"/>
        <property type="gene ID" value="VAB18032_04235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04235"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_1_2_11"/>
    <dbReference type="OMA" id="EWRSADI"/>
    <dbReference type="OrthoDB" id="2084223at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="19677" checksum="AA656F193899FD1B" modified="2011-06-28" version="1">MTPVRFIARAMLSGIFVASGARNFTHPERLVPVAKPITDRMTPLLQRADPRIPTDTTTLIRANAAVQVGAGLMLATGRFTRPAALVLAGTLVPVTLAGHPFWRQEDPAQRHNHQIHFLKNVGLFGGLLLAAADTQGKPGLRWRAGHRIDHSRRSVSRAVRTARREARIAALSAATARRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4G6</accession>
    <name>F4F4G6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42924">
        <property type="protein sequence ID" value="AEB42924"/>
        <property type="gene ID" value="VAB18032_09030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09030"/>
    <dbReference type="HOGENOM" id="CLU_3190362_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="46" mass="4767" checksum="2161255DD74B7532" modified="2011-06-28" version="1">MPATAASATAPTRRPADLAVRGAVPAMLTPPPRSARQRYEAAGHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4G7</accession>
    <name>F4F4G7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glpX</name>
        <name evidence="7" type="ordered locus">VAB18032_09035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731596.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09035"/>
    <dbReference type="EnsemblBacteria" id="AEB42925">
        <property type="protein sequence ID" value="AEB42925"/>
        <property type="gene ID" value="VAB18032_09035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09035"/>
    <dbReference type="eggNOG" id="COG1494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054938_0_0_11"/>
    <dbReference type="OMA" id="AVFYMDK"/>
    <dbReference type="OrthoDB" id="879338at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="36147" checksum="1B68EE582CA1527C" modified="2011-06-28" version="1">MTTTRTRTPQDLDRNLALDLVRVTEAAAMAAGRWVGRGDKEGGDGAAVDAMRKLINSIPMRGIVVIGEGEKDNAPMLFNGEEVGDGTGPEVDVAVDPIDGTTLMSKGMPNALAVLAVAERGAMFDPSAVFYMEKLAVGPAYADVVDINAGVAENLRRIAKVKGTSVSEVTVCVLDRSRHDGLVDDIRRAGAGIRFISDGDIAGAIAAARGESDVDVLMGIGGTPEGITAACALKCMGGMMQAKLWPQDEAEREKALAAGHDLDRVLTTDDLVTGDNCFFVATGVTSGDLLRGVRYRAGGAYTQSIVMRSKSGTIRVIDSYHRLEKLALYSAVDFDGRPLAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4L9</accession>
    <name>F4F4L9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argR</name>
        <name evidence="12" type="ordered locus">VAB18032_15245</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732826.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15245"/>
    <dbReference type="EnsemblBacteria" id="AEB44161">
        <property type="protein sequence ID" value="AEB44161"/>
        <property type="gene ID" value="VAB18032_15245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15245"/>
    <dbReference type="eggNOG" id="COG1438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097103_1_1_11"/>
    <dbReference type="OMA" id="IMGTICG"/>
    <dbReference type="OrthoDB" id="1640037at2"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="10">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="11">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB44161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="171" mass="18090" checksum="918395175C626E4C" modified="2011-06-28" version="1">MTTPLTRAARHARIVELIRDKAIRSQTELAELLGDEGVQVTQATLSRDLKELGAVTARGGDGRAVYVIPEDGHRPLRDAEAAPARLVRLLRELLNEVDSSGNIAVLRTPPGAAQYLASALDRAGLPEVVGTIAGDDTILVVARESDGGAALGERLAGWARRDENVDGSVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4M2</accession>
    <name>F4F4M2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732829.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15260"/>
    <dbReference type="EnsemblBacteria" id="AEB44164">
        <property type="protein sequence ID" value="AEB44164"/>
        <property type="gene ID" value="VAB18032_15260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15260"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_2_0_11"/>
    <dbReference type="OMA" id="HPARHEM"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="24863" checksum="1627CA099DF67D23" modified="2011-06-28" version="1">MSDQQPTIILVHGAFAESASWNGVIDRLGAGYNVVALANPLRSLPGDAAYLRDVMRWVDGPVVLVGHSYGGMVTTQAAADNPSVRALVYVNSFAPDTGESALSLSGQFPGSTLAGTLVQYPVSTGGNEVAIAQDAYHKQFAADASADLAALMARTQRPVTEQALNDGLVGDPAWRSLPSWFVFGDADMNIPVAAHRFMAERANPQGQREIEGGSHAMAVARPGEVAETIIEAVRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4M7</accession>
    <name>F4F4M7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732834.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15285"/>
    <dbReference type="EnsemblBacteria" id="AEB44169">
        <property type="protein sequence ID" value="AEB44169"/>
        <property type="gene ID" value="VAB18032_15285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15285"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OMA" id="HLVHGYL"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="152"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="279" mass="28856" checksum="CB1EB60364A52982" modified="2011-06-28" version="1">MNRPVVVGVDGSPPSLVAAEHAAQEAVWRSRPLHLVHGYLHPLGYGVPINPYEMGLPAPSEDGRKMLEQTAAELVDRWPSLTVEVRQVAGGPGATLVEESRRAELVVVGSRGLGGFAGLLLGSVGTQVAAHGHCPVLVVRPPDRPLPTDGPVLVGVDGSESAELAVGHAAEEAVRRGGTLLLVHVSGERDVDGEHLLATAAAATRGSHPGLTVEERVITGRKPDEALIEASEQAALVVVGSRGRGGFAGLLLGSVSQALVHHSRCPVLVAHPHAAEHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Q2</accession>
    <name>F4F4Q2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_15410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15410"/>
    <dbReference type="EnsemblBacteria" id="AEB44194">
        <property type="protein sequence ID" value="AEB44194"/>
        <property type="gene ID" value="VAB18032_15410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15410"/>
    <dbReference type="eggNOG" id="COG4223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013382_0_0_11"/>
    <dbReference type="OMA" id="TCPADGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307667" evidence="3">
        <location>
            <begin position="24"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="793" mass="80107" checksum="3D77487F954E6951" modified="2011-06-28" version="1">MLRRVAPIVLTLVVVVVGIFALAAGPRTPPPRPGADFVVLVGVAGLRWDDVDPQRTPTLWQLAREGSIGSLSVRSAYRPTCPLDGWLTLGAGSFAGWTGGQRDGTCPPTEVRVDKPDRIGANLPEQESVVMHNQDRLPWGTVPGALSESVRCSVAVGPGAAVAAARPFGRVDRYEPTLPADPAGLLGSCVLSIVDLGTVAGTDPAERAAAARDADAQLARVLAARPPHSLVIVAGVADTEQPSRLHVAVADGPGWDNGWLTSPTTGRRGYLQLIDLAPTALTALGRPMPDRQFLGRPAESVGGRPDDLAAAIAEPADADREAAAQREVAGGFFILLAGVQVALAVAVLPLLRRARRHAGPYGPKPVSRRVVAVVELLLVAAALAMPAALLAEAVPWWRNTYPAVTFAGLTAALLAAATLLVRLAPGYRSTLGPLGAVAGLTMLAVGLDVVTGARLQLNGVIGYSALEGGRYAGLGTVGLGVFIAASLLTAGWLAQRVRREWRPTVMVLIGGAAVVVVGSPYLGADSIGAIALTAGVSVAAAISTGGWLTMTRLAWAGMAGLAVMIGFAVVDLGRPPGERGSLGRFLAALGDGTGGLTVQRSSASSFQTLVNSPLTVLALVGALLLWFALLQPWGGLRRLFGIYPAIRAAMAGTGVAVGIGGVLGAVALDVAGAAAAVVVPMAALSALRVLDHAADRTRPATDRPQDAGPSDAGPPAAGPSDAGSSDAGPADADRSDAASPQAGASDADSSGAGAVGAGDEGSGAAPAGDAGASHEPRRDRGRAIRSSAEVATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4T5</accession>
    <name>F4F4T5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734077.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21620"/>
    <dbReference type="EnsemblBacteria" id="AEB45424">
        <property type="protein sequence ID" value="AEB45424"/>
        <property type="gene ID" value="VAB18032_21620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21620"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_2_11"/>
    <dbReference type="OMA" id="FRFFRFE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="28781" checksum="EDD318445BF4662B" modified="2011-06-28" version="1">MATAQELTPAAIRALTREVSAAEAEALHEQISQLMRQRIESGEWPEHLKLPAEPELAGALNVSRGTVRRAIRTLIEAGLLKQTRGKGTFVRGQMLEQEFAQELISTAQSLDREGVEYQTQVLSARVIQAPSHIAAHLGLPADDLSVLAIRRTRSVAGEVVYLLDNYLPTVLCPDLSPQVLQDRSLFGVLEHDYGVTVESVRRTFSAILPDDDVSAAMSLRPGVPLLYLEQISYQANGNSVEYSDVWVRGDRVRISSWIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4U3</accession>
    <name>F4F4U3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734085.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21660"/>
    <dbReference type="EnsemblBacteria" id="AEB45432">
        <property type="protein sequence ID" value="AEB45432"/>
        <property type="gene ID" value="VAB18032_21660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21660"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099459_1_0_11"/>
    <dbReference type="OMA" id="FAVCEAF"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="191" mass="21507" checksum="22BC1AE2C623F43D" modified="2011-06-28" version="1">MSSRAAITTIDGVGSTVDITNQVKVETLAEVYRRVHAHDLHLVDHRAPTVEERLQWTVDAPGFEAALGYVDGYLVGAVAGCPLPPETLWWRDLTAADDPDLAVEWPGRTFAVCEAFVLPEFRRHRLGIRMTTELLTRRGEERVCLAVAETNTRVWHALQRTGFRHVGDLVPFPGWRPHRMLVRALPLTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4X5</accession>
    <name>F4F4X5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21820"/>
    <dbReference type="EnsemblBacteria" id="AEB45464">
        <property type="protein sequence ID" value="AEB45464"/>
        <property type="gene ID" value="VAB18032_21820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21820"/>
    <dbReference type="eggNOG" id="COG3483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688515_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="39975" checksum="FF73E998B17A3585" modified="2011-06-28" version="1">MAGRATTTGDAATRQLTDFLDIALDKWDGRYDYRSYLALRLLRLPDSADHPPTVEAGDGRRARDRLLVRLVADTLAFELAAAAHTTGLLPQERPGPVLVAKRCRLGVRAVAPALARLGVVEAVGAGTPAAATARLLAVARELVSPGDPSMRLSMLPVHVTHDEYLFIRVLQAYECIFAGVAEELRAAVTALAGNTPATAADRLGYAGDLLRTAGPLFSLLATMQPESFRTFRQYTEGASAIQSRSYKLVESLCRTPEVGRLDSVAYQSVPEVQARVRDGQPTVDQTYRRAVADGRLTGADAVLVARRMATFAGALTQWRRTHLRVAVRMLGARSGTGYTEGTPYLAAVSTAPVFAAVTTDAATPEQNERRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F560</accession>
    <name>F4F560_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase sdr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28356"/>
    <dbReference type="EnsemblBacteria" id="AEB46742">
        <property type="protein sequence ID" value="AEB46742"/>
        <property type="gene ID" value="VAB18032_28356"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28356"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OMA" id="ATPFHER"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="26273" checksum="37F9243CE0AB4EBB" modified="2011-06-28" version="1">MLVTGGSRGIGRAVVQAFAASGDRVAIHHRDSADLAEQLRAELPGTGHVVVRADLADPDAVRAMVDEAADRLDGLDVLVNNAGVFGPADPPHPVFDSSYEQWRQRWREVCDTNLFGAANAAWCAAQHMRTRGGRIVNVSSRGAFRGEPTNPAYGASKAGLNAMAQSLAVALAPYGIAVATVAPGFVETDMTNEHLKAPRGDAIRAQSPFDRVARPEEIAAAVHWLASPEAEWASGTIIDLNGASYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F575</accession>
    <name>F4F575_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28431"/>
    <dbReference type="EnsemblBacteria" id="AEB46757">
        <property type="protein sequence ID" value="AEB46757"/>
        <property type="gene ID" value="VAB18032_28431"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28431"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052338_0_0_11"/>
    <dbReference type="OMA" id="QQMRGWT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="32998" checksum="F8E23C059642DD19" modified="2011-06-28" version="1">MLVLGDEELLATRAVAETVAAARAADPDVDVREYQAGQLSVGEIDEMLSPSLFGGRRVLVLRSGQDARKDLVAALLAYAKHPDPDVQLIVQHLGAAKGKAFADGLKAAGAHIMPAAKLKGHRDRVAFVRDEFRRAGGRCTDDAAEALIAAVGNDLRELAAACAQLIADTDGRIGADTVARYYRGRVEVSGFTVADATMVGDLPGALEALRWALHVGVDPVPIADALADGIRTVARVASAGRGSPYQLASSLGMPPWKVERAQRQARGWTPEGLVQAMQAAAECNAAVKGGSDDRAYALERAVFSVAAARRDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5D2</accession>
    <name>F4F5D2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04490"/>
    <dbReference type="EnsemblBacteria" id="AEB47980">
        <property type="protein sequence ID" value="AEB47980"/>
        <property type="gene ID" value="VAB18032_04490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04490"/>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087206_0_1_11"/>
    <dbReference type="OMA" id="RWPQIVG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="21406" checksum="2A747320C3A055A3" modified="2011-06-28" version="1">MPDESTNPRNDGDRAAARRPASGNPADAKSPDVPDGVSGPELARAVLDAAKARRAATARPRRATDGTGGERRLRGYSGPGPDPRDPQPLGAVLNRLVKARGWQQPAAEATVFGAWEKVVGPEVAQHSRPVKLENGELTVEARSTAWATQLRLLAGSLLQQIGREIGHNVVRRLHIHGPAAPSWSRGPRRVRGRGPRDTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5W7</accession>
    <name>F4F5W7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734179.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22130"/>
    <dbReference type="EnsemblBacteria" id="AEB45526">
        <property type="protein sequence ID" value="AEB45526"/>
        <property type="gene ID" value="VAB18032_22130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22130"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_1_11"/>
    <dbReference type="OMA" id="FEAILCA"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="239" mass="26503" checksum="9BC873CB8362C416" modified="2011-06-28" version="1">MIRAVVFDIDDTLVDFSGATGRGLLAHLATTRAVRPTDAEQYLALWRHLEQIHFTAYLRGECTFTEQRRRRAREFCATAGFPLGPEESETDAWVARYLEHCDEAFTLFPDVLPALDTLRHAQVRLAAMSNSDRAYQHRKLTALGIRDRLEALVCCDDVDGVAKPDPRIFHAVCDRLGLAPAETVYVGDRLDSDARAAIAAGLTGVWLDRTGDGQADVPTITTLDQLVRLLPARTVRKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F603</accession>
    <name>F4F603_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium/hydrogen exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_22310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734215.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22310"/>
    <dbReference type="EnsemblBacteria" id="AEB45562">
        <property type="protein sequence ID" value="AEB45562"/>
        <property type="gene ID" value="VAB18032_22310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22310"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_0_11"/>
    <dbReference type="OMA" id="IGYLLCM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="434" mass="44449" checksum="8C681351688571C8" modified="2011-06-28" version="1">MNGAVSYTVSGLHSVAALTIVLTAAHLFRRLARFVGQPGVVGEITLGLLAGPLILTLGGEDARQALLPADVLTVLHLCGHVGLVLFLVATATELTASTVSLRGRVIAWVTAGTLFPSLAAGAALAGWLLWQNDPDLRGSAPRPAFLIFITIALTVSAVPVLARIIADHRLTGTRAARLSLSSAVVVDAIAWLLLGTAVGLAGTGTHAALTAILVLVGGLGASLLLRRLLATRTVPPALARHPYPVAAVIAMVALVAAHATESGGLTAISGAFLVGLCLPAKQPWTAAAVTRINRLGTALLPAFFVATGLTVWSTGATAVPWLAITVATALAVIGKTVGSYVGARLAGETPHTAQRIGVLLNARGLTEIALLQAGHAAGIVTGQLYLALVVMALVTTAMTGWSLRLVDRRQHREVHGGELPTADSQPLEGPKAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F651</accession>
    <name>F4F651_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28661"/>
    <dbReference type="EnsemblBacteria" id="AEB46803">
        <property type="protein sequence ID" value="AEB46803"/>
        <property type="gene ID" value="VAB18032_28661"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28661"/>
    <dbReference type="eggNOG" id="ENOG50327BZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2358885_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="96" mass="10393" checksum="A18820393B7A0BED" modified="2011-06-28" version="1">MTATLTRNPLRTSLSMTSGHDFSQPLPADHDRQPFGYLFANWEPGTPAETETELGYYDADQQVWVTPDGAITAGVYTKTRTSGSNCGDCVTDDACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F675</accession>
    <name>F4F675_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, asnc family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_28781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735476.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28781"/>
    <dbReference type="EnsemblBacteria" id="AEB46827">
        <property type="protein sequence ID" value="AEB46827"/>
        <property type="gene ID" value="VAB18032_28781"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28781"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_3_1_11"/>
    <dbReference type="OMA" id="CYGPRCV"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="159" mass="17421" checksum="FF21252CA6F5B76E" modified="2011-06-28" version="1">MDEMDWALLRELQADARLSFSELSRRVHLSPPAVAERVRRLEESGVITGYHAHVDLTRAGRTVVALIRMSCYGARCILHDPDVATWPEILEIHRITGDACSVLKVAAGSIGEFEGVIDRLAPYGQPSSTMVLSSPLNWQPLTRCPDVPPVTAPGRGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6B0</accession>
    <name>F4F6B0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RDD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_09690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731727.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09690"/>
    <dbReference type="EnsemblBacteria" id="AEB43056">
        <property type="protein sequence ID" value="AEB43056"/>
        <property type="gene ID" value="VAB18032_09690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09690"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054176_0_0_11"/>
    <dbReference type="OMA" id="WMLTGGP"/>
    <dbReference type="OrthoDB" id="1974702at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="348" mass="36448" checksum="B8BCBF50ADBB70E0" modified="2011-06-28" version="1">MSTAARWTAPAAGDADLVSGEAVRLDVRAARIGSRVLALLIDVLLQLVFGLLLVVITALTLAALPYGLFDAALERALLTVGVVLLLIGYPVCFERLNEGRTPGKAAVGLRVVSHDGGPVGLRQSLTRALVGVAVEWPGLVLPLLSWVAGATVMLTDARGRRLGDLVAGTLVVHTRTAVSWRPVPAPLPVLTTWAYTLDLSRLDPSLALATRQYLTRSHQFAEPARSDLARQLWREVAATTGPPPPAGLPESVYLAAVLGERHRRARQRLAGERGLTAALWPQLGSTPTFRSAEPTLTAPLPDPVPTSVPGPVPSPRAVEAGQAAPGGLVGVRPSVPARRSGADGTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7A6</accession>
    <name>F4F7A6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731835.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10230"/>
    <dbReference type="MEROPS" id="S12.950"/>
    <dbReference type="EnsemblBacteria" id="AEB43164">
        <property type="protein sequence ID" value="AEB43164"/>
        <property type="gene ID" value="VAB18032_10230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10230"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_2_11"/>
    <dbReference type="OMA" id="FAEPRVY"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="410" mass="44779" checksum="08E3FB0766ECCB05" modified="2011-06-28" version="1">MSIARSIDPAQVGFDPARLARIDEHFGRYVDDGRLAGWQVVVTRRGEVAHCSTYGLRDRESGAAVQADTLWRIYSMTKPITSVAAMILWEEGRFELTDEIGRWLPEFADMRVYSKGSTLKPYTVAAIEPIRVWHLLTHTAGLTYGFMQTSVVDGLYRAAGYDLYPPSDVDLAGACRAFGELPLLFQPGTAWGYSVATDVLGRLIEVVSGQSLDSFLTERILRPLGMEDTRWYVDGADAARLAALYAADPKTGRAVRHDALGALAYEKPALLSGGGGLISSAADYHRFTQLLLRGGELDGARLLAPRTVRFMTRNHLPGGRDLGTLSTGGFAETTLDGIGFGLGFAVVEDPIPSRVPSSVGEYYWGGVASTAFWVDPVEQITAMFFTQLMPSSTWPIRPQLRQLVYSALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7I9</accession>
    <name>F4F7I9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733088.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16620"/>
    <dbReference type="EnsemblBacteria" id="AEB44428">
        <property type="protein sequence ID" value="AEB44428"/>
        <property type="gene ID" value="VAB18032_16620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16620"/>
    <dbReference type="eggNOG" id="ENOG5031Q56">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2358883_0_0_11"/>
    <dbReference type="OrthoDB" id="764010at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="96" mass="10298" checksum="02F0A2391D2B7687" modified="2011-06-28" version="1">MGGPADDLGRLDAFTFPTVPERGVYLAIMRLFTASLMTDLSAQQVVEELAAHEIDISLVRSANGCSGRPMRCSSARTRPGRSVGLRLPALSSACFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7J4</accession>
    <name>F4F7J4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin synthesis CobW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_16645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733093.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16645"/>
    <dbReference type="EnsemblBacteria" id="AEB44433">
        <property type="protein sequence ID" value="AEB44433"/>
        <property type="gene ID" value="VAB18032_16645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16645"/>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_2_0_11"/>
    <dbReference type="OMA" id="WHPEHGD"/>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="3">
        <location>
            <begin position="273"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="437" mass="47975" checksum="9B5EFCFA441B97EA" modified="2011-06-28" version="1">MPSSPQAPTRAVTADADTRPSLTVLSGFWPSATFAVARALLAADESLLLVRHDLAGIRDGVVRRVVRSGAGIIEDEQVVLRHGCVSCTLREDVLPTLVRLTHGHPGRDLVLMLPEVAEPEAVAAVCAHCLVDGAPIADHLRIDSYVTVLDAEHLLDGLTSTEDLITLGIQAAADDHRSLADVVVRQIEYADTLVLWGQSREGEFDTGRMAVLLQRMAPWAAHIRVDSDIVDAGMLTRQLRHTHRYRLETPGVLARGLQGYTLGVHEPKPDCGVVSAVFRARRPFHPQRLHDVLEEVNAEVIRSRGHLWLASQPDTVVAWEFAGGGLSMGSLGHWLVSLPEDRWEHVDDQRRLAAALDWDPYYGDRHQHLVFIGLDIDPVELHRTLAGCLLTDAELADGEETWRTYHDPFAGCFPLGAEELTDTDTDTDTDTEGAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7L4</accession>
    <name>F4F7L4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44453">
        <property type="protein sequence ID" value="AEB44453"/>
        <property type="gene ID" value="VAB18032_16745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16745"/>
    <dbReference type="eggNOG" id="ENOG50309GA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015441_0_0_11"/>
    <dbReference type="OrthoDB" id="1924546at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="30775" checksum="84C0773FDCC4F4A2" modified="2011-06-28" version="1">MWLHWEMKRANFDTWCGYDIEHLFAAGVQATVGFVRDSAHAERNDVLERLLDEAGEPHVSEEDLAEWAQRERSRFPADPAAEDPLRWVQRAKLMGEGELARRWLDRWAAGRQRDKSTLSQLRYQLADLGAFAEAAKAQRESIQFADNPWDSASAWQSLAQLERQAGGHRAAWEALRACRRALDGVAGWTAVGLGRMYVEELFLLAGSADAELADVVFAEADRQARQVPGLPLVVLQAAAEAAGKIGNQARAEHYLKLRDAEQRRIDVEMSRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7S6</accession>
    <name>F4F7S6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23065"/>
    <dbReference type="EnsemblBacteria" id="AEB45713">
        <property type="protein sequence ID" value="AEB45713"/>
        <property type="gene ID" value="VAB18032_23065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23065"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065153_0_0_11"/>
    <dbReference type="OMA" id="RQESANP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="35841" checksum="1CC0C4DA5FB722FE" modified="2011-06-28" version="1">MSIVEDVGAQVRAAAEELPLGLLTQALEKFGLATERLRWVRQESANPMGVPELSAATEHAETAGYALRVAQEQLTAYLAAIGLAPDGAAPPAGAPERRGVHDDPRAAGPVADAAPEPAGDVRLRRWWAVRVAELTGGREGPAEQPDDRVTDSQELLRRVVRGVRAGDRDRLHRELRGAHADVGMGLAAVAPPLLRDLAGQLLGHPPRGDDLPRLHRELDGRVRDLLPGLPPPVLDTLLTRVCRMPPPRRGNDDQPHAADPAVTAGVLTGVLLDRLGRDLPDAGSTQPTTNTGGTPSTPDATRPAGQRPPRREAPWDGPPRRPIAEHGMAGRSGNGIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7X6</accession>
    <name>F4F7X6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735599.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29401"/>
    <dbReference type="EnsemblBacteria" id="AEB46951">
        <property type="protein sequence ID" value="AEB46951"/>
        <property type="gene ID" value="VAB18032_29401"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29401"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046120_0_0_11"/>
    <dbReference type="OMA" id="QPRNMSM"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="301" mass="31168" checksum="E197CA362837443D" modified="2011-06-28" version="1">MSDPRITSSIFTRGAVDLSALRTPAPSPAPAQAGPPAAAPGGSVGGAAVIDVTEANIQSAVLERSLTTPVVVFFGAAGYPESDQFAPVLERLAAEGGGTWLLARVDVQQQPRLAQMFQLQALPTTYAIVGGRPVDAFPGVVPEPQLRQWLQAVLKAGGVSVAEPEDPRLDAADDALMDGDLDAAEQAYRKILAETPNDAAAEAGLAQVGLARRVSGADPQTALAAATANPDDVDAQLLAADIEVLSGQAEQAYQRLVGLVRRTAGEDREKVRQHLVGLFTIAGPEDPTVASARRALASALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8M1</accession>
    <name>F4F8M1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltooligosyl trehalose synthase</fullName>
            <ecNumber evidence="2">5.4.99.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.15" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734416.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23330"/>
    <dbReference type="EnsemblBacteria" id="AEB45764">
        <property type="protein sequence ID" value="AEB45764"/>
        <property type="gene ID" value="VAB18032_23330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23330"/>
    <dbReference type="eggNOG" id="COG3280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005045_1_0_11"/>
    <dbReference type="OMA" id="WTVVEKI"/>
    <dbReference type="OrthoDB" id="217555at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047470">
        <property type="term" value="F:(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013797">
        <property type="entry name" value="Maltooligo_trehalose_synth_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="15"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="763" mass="83223" checksum="53B3B2FFD4DACB2B" modified="2011-06-28" version="1">MTDTAGPVGATYRVQVRPDFDLDATAGLAGYLADLGVTHLYSAPLLTAAPGSTHGYDVVDHRQVNPELGGEPARQRLLRALRSVGLGLVVDIVPNHAGVAVPAANPAWWDVLRRGRDSAYANWFDIDWARGRLLLPVLAESPDALDALTIVDGELRYHEHRFPIADGTGDGSPREVHDRQHYELVCWRRGDAELTYRRFFAVSSLAGLRVEDPAVFAATHELILAWAANGEVDGIRVDHPDGLRDPAGYLARLRDAAPDTWLIVEKILEYGEELPAWPVDGTTGYDALAAVCGLFVDGDAEADFTALDTRLTGRATSWADLTHDTKLGAATRLLAAELTRLAALAPEVDPDAARAALAELAAAFPVYRGYPPDGVRHLANARAEAGRRRTDLTGALDAVTRRLRDPDDELARRFPQFTGAVMAKGVEDTAYYRWSRFVALNEVGGSPTHFGTLPGRFHRFAVARHDRWPTSMTTLSTHDTKRGEDVRARLAVLAELPQRWAQLVTGWMAAVPLPDAALAHLLWQTAVGAWPVERERLHAYAEKAAREAAVSTGWTDPDPAFEQAMHALVDAMYDDPAVSAELAAFAAEITPAGWSNSLGQKLIQLAMPGVPDTYQGTELWDNSLVDPDNRRPVDFGVRRELLARLDAGWRPAVDDTGAAKLLVVSRTLRARRDRPELFGDYQPMLVHGPAARHAVAFDRGGAVAVATRLPLRLAAEGGWRDTTLSLPVNQMSCLFTGRVYRDGRVRLADLLATYPVALLVPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Z8</accession>
    <name>F4F8Z8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin (Vitamin B12) biosynthesis CbiX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_30036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30036"/>
    <dbReference type="EnsemblBacteria" id="AEB47078">
        <property type="protein sequence ID" value="AEB47078"/>
        <property type="gene ID" value="VAB18032_30036"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30036"/>
    <dbReference type="eggNOG" id="COG2138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056929_3_0_11"/>
    <dbReference type="OMA" id="PCRVSYA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="28886" checksum="838AA738F91BE16B" modified="2011-06-28" version="1">MRTAPLTDQAEAPADPARSGDRAGGVAASAEPVVLVAHGSRDPRAAEAIRGLARAVSVARPGQPVLASWLDHTEPDPTTVLRELAAAGHSRAILVPLLLTAAYHRRVDIPTAVEAAQRSGLTIRVDITDVLGPVGDEVDPALLAALRHRLAEADPGRFDALVLAAAGTRDPAARASVGRVARALGAALDMPTRVSYASAAPPAVDVAVQRLRAAGAQRVAVAAYFLAPGLFHDAVTTAARAAGAIAVSAPLTTAPDLVNLILHRLSQPPHALVEHEVDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F941</accession>
    <name>F4F941_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propionyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04715"/>
    <dbReference type="EnsemblBacteria" id="AEB42069">
        <property type="protein sequence ID" value="AEB42069"/>
        <property type="gene ID" value="VAB18032_04715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04715"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_1_11"/>
    <dbReference type="OMA" id="PQVCALF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="259"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="511" mass="54423" checksum="4D6C9743C0BD7F28" modified="2011-06-28" version="1">MVTVDGGALEQLGKRVRAGGAEKYHAANAAKGKLFARERVALLVDEGSFVEDGLYANALADGLPADGVVTGTATIDGRQVCLMANDSTVKAGSWGARTVEKIIRIIERAYDTGVPMVYLVDSAGARITDQVELFPGRRGAGKIFWNQVRASGSIPQVCALFGPSAAGGAYIPAFCDVVAMVDGNASMYLGSDRMVEMVTGEKTTLEAMGGAKVHCAESGVGHFLCKTEAEALDVVKRYLSYLPANWTQQPPTAEAVAAPAKADLAALVPASERQAFDMRRYVKGLLDEDSFFEIQALWAKELTIGFGRLNGEVVGVVGNNSMFKGGVLFVDSADKASRFVQLCDAFNVPLLFLSDVPGFMVGSAVEKQGIIRHGAKMITAISEATVPKICVVVRKAYGAGLYAMAGPGFEPDATIALPTAKIAVMGAEAAVNAVYANKIAAIEDEAERAAFVAAKRAEYEQDIDIVRLASELVIDAIVEPHELRAELIRRFTAARSKDRHFSRRRHGVTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9F7</accession>
    <name>F4F9F7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732022.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11165"/>
    <dbReference type="ESTHER" id="verma-f4f9f7">
        <property type="family name" value="Bacterial_Est97"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43351">
        <property type="protein sequence ID" value="AEB43351"/>
        <property type="gene ID" value="VAB18032_11165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11165"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097569_0_0_11"/>
    <dbReference type="OMA" id="EIPGILW"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="243" mass="26297" checksum="32E3022A2F3DD5E2" modified="2011-06-28" version="1">MEFTSEQRLNDGVLEREFTLGEIPGILWRPASVSARAPVILIGHPGGLPTMYPRLAARAQHCAAEGFAAATIELPGGGNRPRLVAVEEARTELRRALQAGEPVGDEVVDRLVLPLVDQAVPEWRAALDALLSLPEIGGPVGYSGGIIAIGVRLAVVEPRIVAALLFAGSFVPRAMFEEARKVTIPLQVLLQWDDEGNDRQQALELFDAFGSTEKTLHANMGGHTGVPQFEGDDANRFFVRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9S9</accession>
    <name>F4F9S9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734507.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23785"/>
    <dbReference type="EnsemblBacteria" id="AEB45855">
        <property type="protein sequence ID" value="AEB45855"/>
        <property type="gene ID" value="VAB18032_23785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23785"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_0_11"/>
    <dbReference type="OMA" id="GWTMGGQ"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="325"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="449" mass="49578" checksum="D30BF4F7CB60792B" modified="2011-06-28" version="1">MVTRTPHVLIIGAGTGGLCLAHGLRRAGIGVEVYERHRTRADGLLGYRVGIGPTGSRALRDCLPPELFDIYLATCARSPRYFNVLDQKLRPTASFPLRPDTHPVDTERSVARMTLRQVLLTGLEDVVHFDRTFTRYEQHHDGTVTAHFADGSTATGDLLVAADGTQSAVRRQYLPHAVIRDAGTINIATRIPLTDDTRALLPPAVQRGISLIFGTGGMMGVLHVMEFKWDADGRLKPDVDPADAALLADWPGLRHDSTRDNINLVVWSTARRFPEDVMRRRGSELIQVALDLTANWHPRLRQLLRQADPDSALPIRVSTSEPVPPWHSSTVTLLGDAIHTMTPGRGVGANTALRDANLLRRQLILAAAGEKSLVQAVADYEAVMVPYGFARVADSLARSGTSGDDRMYKPVFGRLALLGARGYFRVTSRVPRLRRKFVDDFYTYRGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAE3</accession>
    <name>F4FAE3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Atpase associated with various cellular activities aaa_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732041.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11260"/>
    <dbReference type="EnsemblBacteria" id="AEB43370">
        <property type="protein sequence ID" value="AEB43370"/>
        <property type="gene ID" value="VAB18032_11260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11260"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="OMA" id="RRIQCNP"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="54"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="259"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="37935" checksum="E90EF907860C4DCE" modified="2011-06-28" version="1">MTDISDTMASLPSPADPDATAADLEQTLNEVRRVIVGQDQLVERLLIALLADGHCLLEGVPGVAKTLAAQTLATVVGGTFSRIQFTPDLVPSDIVGTRIYRASKESFDVELGPIMANLVLADEINRAPAKVQSALLEAMAERQVSIGGRSYPVPEPFLVLATQNPIESEGVYQLPEAQRDRFLMKIVVDYPDGADELAILYRMSADRPRPHQVLRPDRLRELQLRARQVFVHHAIAEYIVRLILATRDPARYGMPEIAPLLAYGASPRATLGLVAAARAQALLRGREYVLPDDVRDLAVDVLAHRLVLSFDAVADGISAESVVHRLVDVVPLPRVANGQPEYVADLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAP9</accession>
    <name>F4FAP9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microcompartments protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733319.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17810"/>
    <dbReference type="EnsemblBacteria" id="AEB44664">
        <property type="protein sequence ID" value="AEB44664"/>
        <property type="gene ID" value="VAB18032_17810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17810"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064903_5_3_11"/>
    <dbReference type="OMA" id="QFREGVN"/>
    <dbReference type="OrthoDB" id="1977809at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="108" mass="11192" checksum="2ABF3FAAB9A0A306" modified="2011-06-28" version="1">MPSDIAIGIVETRGVVALSAGIEAMIKTADVRCIAVERVTSGYLAAAVQGTLAAVRQAVAAGEAAIRQHGELRSSQVYPKPHPTTAALLEDPEAARIREVMASLRGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAS5</accession>
    <name>F4FAS5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vwa containing coxe family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733345.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17940"/>
    <dbReference type="EnsemblBacteria" id="AEB44690">
        <property type="protein sequence ID" value="AEB44690"/>
        <property type="gene ID" value="VAB18032_17940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17940"/>
    <dbReference type="eggNOG" id="COG2425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568468_0_0_11"/>
    <dbReference type="OMA" id="MVNCTIL"/>
    <dbReference type="OrthoDB" id="434825at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="454" mass="49994" checksum="B74CA7983F631C24" modified="2011-06-28" version="1">MTDSDLSPDDISPGDLAAANRRQVLYWRLLGRIFDPDEQPTLESASMAVVDDLGLPAMLLDPTVSVDTVVQRFPQLADELRGLLADTEADPADEAAGPHRPGEAEVRRAALVSKLLLNVFATGAGPVSAGQLARWQSDAGWFEQALGGEPGELRRQGTGLGPTLAGIEGDLVNRMHLREVLADPALARQLTPSMSLIEQLLRDKANLSGVALANAKALIRRFVDEVAQVLRTQVEQTTVGAIDRSVPPKRVFRNLDLDRTIWKNLPNWSPEDERLYVDRLYYRQTARKTTPSRLIVVVDQSGSMVDSMVNCTILASIFAGLPKVDVHLIAYDTRALDLTPWVHDPFEVLLRTNLGGGNDGPVAMAMARPKIVEPRNTVMVWISDFYEFDRSQPLFDGIEAVHRSGVRFIPVGSVSSSGQQSVNPWFRQRLKDLGTPVISGHIRKLVFELKSFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAW2</accession>
    <name>F4FAW2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734577.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24135"/>
    <dbReference type="EnsemblBacteria" id="AEB45925">
        <property type="protein sequence ID" value="AEB45925"/>
        <property type="gene ID" value="VAB18032_24135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24135"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324134_0_0_11"/>
    <dbReference type="OMA" id="RCAHCIR"/>
    <dbReference type="OrthoDB" id="1918349at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="79"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="191" mass="19576" checksum="8BC877DC173D66AF" modified="2011-06-28" version="1">MAVVLAAQLATLTCDNCGDSVTGTRPLADGEVVWTLLSEHGWGGSPLADGPHRCAHCIRFGPTPGTPPGGILGIEHLGGVTVVTTAGDVDLDTGDTLRMALRHAADMGGHVLVDLVRTDLIDSTALGLLVRAHHDAVERGARLCVAVTSPLIRQVLQVTGLHDVLAVADNRTAALAYLAADQSTAPTSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAX3</accession>
    <name>F4FAX3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24190"/>
    <dbReference type="EnsemblBacteria" id="AEB45936">
        <property type="protein sequence ID" value="AEB45936"/>
        <property type="gene ID" value="VAB18032_24190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24190"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_11"/>
    <dbReference type="OMA" id="QFIMVAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="313" mass="34602" checksum="8D83238BE099D27D" modified="2011-06-28" version="1">MVTAEAAEPATAPAPTPRRRRRGIRQTRGYRAFQVVNAIILTAVVVVTLYPFVNIVARSMSHEAYIIAGQVNLVPRGFTLDTYQLVLSDSMFWTNYRNTVFYTVTATLISIVMTTCYAYVLSKKDLKGRSALVGIAVFTMFFTGGLIPNYVLVTSLGLKNSVWAIALPNAINVFNLLVMKAFFESLPNDLEEAAAVDGLNTYGILWRIVLPLSKAIVATMVLFYAVAFWNSWFAAFLYLDRQELWPVTIYLRNLIAGATGAENIGAISEANEVQAEATLKAVTIVLTTLPILLVYPFVQRYFVRGIMLGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB44</accession>
    <name>F4FB44_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Interferon-induced transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735834.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00525"/>
    <dbReference type="EnsemblBacteria" id="AEB47189">
        <property type="protein sequence ID" value="AEB47189"/>
        <property type="gene ID" value="VAB18032_00525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00525"/>
    <dbReference type="eggNOG" id="ENOG5033FE5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140587_0_1_11"/>
    <dbReference type="OMA" id="KWALIVG"/>
    <dbReference type="OrthoDB" id="2046989at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="99" mass="10435" checksum="B0C0BEAA3D815631" modified="2011-06-28" version="1">MQPGYPSQPPQQVDNNMTMSIVAIFLFWPLAIPAIINASKVNPLLQQGDYAGAQAAAAESKKWSKWALIVGIAWIAIVLVCCVGGSLLGAISGNSAMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB66</accession>
    <name>F4FB66_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phage shock protein C, PspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_00635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735856.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00635"/>
    <dbReference type="EnsemblBacteria" id="AEB47211">
        <property type="protein sequence ID" value="AEB47211"/>
        <property type="gene ID" value="VAB18032_00635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00635"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030489_2_0_11"/>
    <dbReference type="OMA" id="PSWWRDP"/>
    <dbReference type="OrthoDB" id="1184733at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="122"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="569" mass="57931" checksum="4DC9BBC61C12641D" modified="2011-06-28" version="1">MTDDAAQPNRPEPTDAGTTPPTASPGPAAASAGATGDHTAAPGSPPMPTAQTPSSAPTAPAGPGPASPPGYDQTAPPPPGGGSPGAPPPPGGAGGPYGGAGGPYGGAGGPYGGAGFTSRYGLVRPRDGRYLAGVCAAIGRATNTDPVLWRVLLAVLGFFGGVGILIYVIGWLIIPGEGDTASPVESMLGRGRSSMSPVTVIVLSILVAVAFGYIVTDAFRAVLLGAAILVGGALLLNRQQHQTQPEPAPMTTPPSAPVPPVSYPAPSVYSPAYAASTQTRTHIPPYGPVPPPGTPSTAAPREPNMPPSPTPPWPTTSTQSAPLGPPPPAPLPPTYRPPFAPHGPYASRTMPPPPPQAPPKPPKKPRERSALGAVTFSLIFVALGLVVVLDMLNVFGIGASAYFAAALAVIGLGLLVGTWFGRARWLIALGLVTAAALAVATVAESYNRLGGIDGAVVWAPTNQRELALRYEQSFDDAVLDLRAIDFSQLDTEVTVVINFGEATVLVPPNVDVTTVTQVTAGDADIFGEQRGWGRDNHRREIVDLGPDGPGGGKLRLNLHVNAGKMEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB70</accession>
    <name>F4FB70_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_00655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00655"/>
    <dbReference type="EnsemblBacteria" id="AEB47215">
        <property type="protein sequence ID" value="AEB47215"/>
        <property type="gene ID" value="VAB18032_00655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00655"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873278_0_0_11"/>
    <dbReference type="OMA" id="LDWHGVR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="164"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="307" mass="32202" checksum="713356D8B6D217DA" modified="2011-06-28" version="1">MRAGVGVEQVRRVGAYGVLRDPDGRVLLVRGSARADFPGVWSLPGGGLEHAEHPARAVLREVAEETGLAVEVTGLRAVVADVTPYPDLGVALHTDRVLFDVTAVGGTLRGEPDGTTDLARWLSPDEAAGLPLLPFTAEALGLPVVPLPSGALRRREPFAAPDAARRQRFGAYGLVSDPAGRVLLALIADGYPGAGQWHLPGGGTDHGEQPVTALLRELVEESGQLGRVTELIGVDNLHNPAALGPEGYPIDWHGIRVVYRVLVDRPTEPAVTELAGGSTARAAWFTPAELRELPLTEIAAEAVATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBC8</accession>
    <name>F4FBC8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mur ligase middle domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730897.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05490"/>
    <dbReference type="EnsemblBacteria" id="AEB42224">
        <property type="protein sequence ID" value="AEB42224"/>
        <property type="gene ID" value="VAB18032_05490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05490"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041144_0_0_11"/>
    <dbReference type="OMA" id="NECMAVN"/>
    <dbReference type="OrthoDB" id="362744at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008337">
        <property type="entry name" value="Capsule_biosynth_CapB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01758">
        <property type="entry name" value="CAPSULEPROTB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04012">
        <property type="entry name" value="poly_gGlu_PgsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="1">
        <location>
            <begin position="41"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="425" mass="46396" checksum="C457FA61FE01BEF5" modified="2011-06-28" version="1">MFYLYTVYSLCCLALVVAGVIEQRNHYRNLNTIPHRVLVNGIRGKSSITRLCAGALRGGNKVVVAKTTGTAARFIFPDASEEPVHRKFGIANVVEQIGIVRRAAVYHPDALVIECMAVMPALQEINQSKLIRSNIGVLCNVREDHLAEMGPTLDDVARSLSRSMPEGGICITAEKDRLAILEQEAAKRNCRLISVDPESVTDQEMAGFGWITFKENVAIALAVAAELGVDRRSALAGMWAAPPDPGVLSVARVLYQEKRVRFANIFAANDPESTFMNIQQLEQQQLINRPLTMVINCRPDRVERNGQMGTLAGRVQPQQIVLIGEMTRSARVNVPADLQSRVVDLGGKLPPERLVAEVMAATAPDGSVIAVGNIHGQGEVLLHELAALPSWEPRGRDRAESMLRTPSTPGFDVDAETVFLGGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBL5</accession>
    <name>F4FBL5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732146.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11815"/>
    <dbReference type="EnsemblBacteria" id="AEB43477">
        <property type="protein sequence ID" value="AEB43477"/>
        <property type="gene ID" value="VAB18032_11815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11815"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076645_1_1_11"/>
    <dbReference type="OMA" id="WIDGQAR"/>
    <dbReference type="OrthoDB" id="1966598at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="22307" checksum="9C4C6A4B65CCE9AE" modified="2011-06-28" version="1">MGSAELDELIVADADALRDWLSAHHATSAGVWLALTRKGGTVTTLTWQQAVDEALCFGWIDGQARKRDEESSWIRLTPRRSRSSWSQRNVSHVARLEEQGRMQPSGRAAVEAAKADGRWAAAYAPPSEAEVPADLLAAIAANPAAQAMFDVLTKTNRFALIHRLNAAKRAQTRERKIVEFVAMLARHETVYPQKARPSTPPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBU5</accession>
    <name>F4FBU5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18215"/>
    <dbReference type="EnsemblBacteria" id="AEB44745">
        <property type="protein sequence ID" value="AEB44745"/>
        <property type="gene ID" value="VAB18032_18215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18215"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_11"/>
    <dbReference type="OMA" id="ICCALAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="420" mass="45288" checksum="B6C4CE99E86AAE54" modified="2011-06-28" version="1">MATAALLAACGGGGDDAADGPVTLKVLTWEPGGTEYWQQVKSTFEASHQDIKLELQSVPFDKYPEVQGPYITSQSGPDVMANNAGLELFDRRGAYTPLGDKAAEINKDLVTYSGACEEFDTSKPCYGVPFSYQGNVLYYNKDVLTAAGLDPENPPATWDEFGAACDAVKKAGKTCLALGLSGTFPAYWDFPEIARNYLTEDDIRGVLNGTLSWKDPKLVQVLEKLAEITTKGWANKNAPSITMLPDGADIFQRGDAAFAGTIISDAVNWEAFGKALGDDKLGVTRWPAINPSAPLAGKFSGIEGAVYGVTKWSEKKEAGLKFITWLAGKENGELWVKYAKGQPLNKNVDPALLPESPAFKKIQELIAEPTLHAGVMLSGPEADALARGWQQVTLGQLTVDKWADQMQQALERSPTKKQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBW9</accession>
    <name>F4FBW9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733424.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18335"/>
    <dbReference type="EnsemblBacteria" id="AEB44769">
        <property type="protein sequence ID" value="AEB44769"/>
        <property type="gene ID" value="VAB18032_18335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18335"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_8_2_11"/>
    <dbReference type="OMA" id="GLAMESF"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="30036" checksum="7C6F22677CBB3529" modified="2011-06-28" version="1">MYEIGVNPWVWASPVDDAALADLVPRIARFGFDAVELPIEQPGDWDPARTRDLLTAHGLTAAGVCAVTPPGRDLVDATPEVVEATRAYLRGCVDAAVAVGAPTVGGPVYASVGRTWRMSVAERAACYADFRRALTPVADYAGERGVAIGVEALNRYETSVVNTIEQTLDLIDGLPPNVGLMIDTYHMNIEEADPYAALAVAGSHIKHVQVSGTNRGAPGADHLDWPRFLAVLTTTGYRGAVCIESFTPDNDTIATAASIWRPLAPSPDRLALDGLAHLRGILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBX4</accession>
    <name>F4FBX4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ordered locus">VAB18032_18360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733429.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18360"/>
    <dbReference type="EnsemblBacteria" id="AEB44774">
        <property type="protein sequence ID" value="AEB44774"/>
        <property type="gene ID" value="VAB18032_18360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18360"/>
    <dbReference type="eggNOG" id="COG1182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088964_0_1_11"/>
    <dbReference type="OMA" id="REGWDHS"/>
    <dbReference type="OrthoDB" id="1402654at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="22979" checksum="4A2A753E6DF253D3" modified="2011-06-28" version="1">MTLFRLDASIRTHGSASREIADIVEQEWLANRPGDTVERRHVGVDTLPSTAWAAALSASMTPAEEHTPEQQEAVALAATLVDELLAAEALLFAVPLYNYGVSQHFKTYIDLVLTDPRANGQPFLAGKPVVLATVRGGAYGAGTPREGWDHSTAYLRRILADCWGADLTVIEREFTLVGVAPALDAFADVAAEMHAGALESAREAGRALGGALSVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC15</accession>
    <name>F4FC15_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_24575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734665.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24575"/>
    <dbReference type="EnsemblBacteria" id="AEB46013">
        <property type="protein sequence ID" value="AEB46013"/>
        <property type="gene ID" value="VAB18032_24575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24575"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056335_0_0_11"/>
    <dbReference type="OMA" id="DHEMRAV"/>
    <dbReference type="OrthoDB" id="1707650at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="137"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="32485" checksum="CA11018F60F683CD" modified="2011-06-28" version="1">MTSLVLLAWATAVALLAPSALTGRWTTSLPRLTVGLWLGAELSVTVAVLAAGLFVAVPPAALAAGLDGIVTACLRALAGMGALHGALAVTALLATAILVARLLVSFVRTFLSARRWRRRHLAALLPLSRQDADGWTIVDHTDAAVYCLPGRPGKVIVTSAAFDALTADEFAAVLRHERAHLRGRHHLLVALAAAFHRALPGLPMAEIAEREIRRLVEHLADDRASEHHGRQAVATAIVRLADRTPRHALGAATGAVERVRRMLAPPARPRIRHRLVAATAIALLLAGPAAVTVASAGVAVQSVTCPIGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCF2</accession>
    <name>F4FCF2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05765"/>
    <dbReference type="EnsemblBacteria" id="AEB42279">
        <property type="protein sequence ID" value="AEB42279"/>
        <property type="gene ID" value="VAB18032_05765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05765"/>
    <dbReference type="eggNOG" id="ENOG50348AK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2071442_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13022" checksum="BF2A365B648E4934" modified="2011-06-28" version="1">MEQQGIDQRGIVSRVTTGMRVVDVAGRDVGTVDLVQRGDPNAVTVQTPTADPGGSLDELIESATPEEPDVPADLAARLLRTGYLKVSTDLVPTGAVYVLADQIASVTDHEVLLDALTADLPAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCF6</accession>
    <name>F4FCF6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_05785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730956.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05785"/>
    <dbReference type="EnsemblBacteria" id="AEB42283">
        <property type="protein sequence ID" value="AEB42283"/>
        <property type="gene ID" value="VAB18032_05785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05785"/>
    <dbReference type="eggNOG" id="COG2807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038046_0_0_11"/>
    <dbReference type="OMA" id="RDPLAWQ"/>
    <dbReference type="OrthoDB" id="806182at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="40"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="430" mass="43851" checksum="F466C0751A5736BC" modified="2011-06-28" version="1">MPSSPAGTPAVPTSTADGSTAQGTQVVPATGGPTASRAHGGLLVLVGMLLVALNLRAAVTSLGALLDEVRVGLALSGTMAGFVTTLPTIAFAGLGAATPWLVRRLSTARLLVLGMLALAVGQVLRAVTGSAVVFLLTSALALAGIAVANIMMPMLVKQYFPHRTGLVTGAYTMALVAGTTVAAAAAVPVAHAFGSWRAGLGVWAGLALVAVLPWLPAALRSRGTDARRATRDGVARVIIRPGRTRLGWAMAVYFGAQSLSGYAIMGWLAQLFRDAGFRPQDAGLLLAAVTALGVPIALLMPTLAGRLKNLRMLVFALTAASTLAYLGLALAPRDAAVLWVLLLALGQGAFPLILTTIGLRARTADGTVALSAFAQSAGYVIAALGPLLVGILYEGTGGWTAPIGFLLLALAVQTGAGMVIARPRYIEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCX1</accession>
    <name>F4FCX1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733458.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44803">
        <property type="protein sequence ID" value="AEB44803"/>
        <property type="gene ID" value="VAB18032_18505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18505"/>
    <dbReference type="eggNOG" id="ENOG5030PQ6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390260_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="707" mass="76276" checksum="A7302947BA12EA55" modified="2011-06-28" version="1">MYATTMTIDADDDQPVVAHRFDPRRHRRIPGLFDLWLTSGARGGLVLPTKPDRPLTARAITELVLRSGEAADDVRILTDDGARHAELFSEVAGLLAHDVLISPEGAEIRQHGGRGGPLHAVPVDREARRARDWLVIQPPDLATPLPGWFTVERGLVRPRKGVVSLPLHGGAVLATRADFVARRATAHRLGTTVGGLVTVAVTARAGGFLVGDYGGTQRVYRGDQLAALLGDLPLYGSDLRLWLTWPSDPEEQHSLGTHARELAETTGATVWTPPPGGSAELVDGRHDLRALDHAGRPAEWHAYRPPFAAGPPALRTTPTGLLVPASARLSLTVHPASPPDIEAEQTDPSPAVGSPAPPPVEPSPDTTATQPTDRIPQTAEPTEQVSADADGPTRQVSAQADEPVERVLAAAESARAGVPATPLARPALAGEDRRPPGYGLRWLSPGQQVNAERFEAFVASPVDAQTVGEGLPGAELFLLAFLDPRSVPEGRRLLRVRVDPGGAIPMSALRARLPARLQHLRGLREAYLLPAARLDRVVAVDTFTVDPAGELTSTGECVPEPLSIRCGSPARLTAGLPHEVRRWPAFGTRRAYALLPADRVRLPRHWLRLYRRQPPVTAGRLMVELRVPRGRTIDVTATADLLAPLSRVRSRAEALRAAQVELILASRSYPRVRVRRAYRAEAGAWQRVPRLDQGPLPSVLPRLQPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD02</accession>
    <name>F4FD02_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733489.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18660"/>
    <dbReference type="EnsemblBacteria" id="AEB44834">
        <property type="protein sequence ID" value="AEB44834"/>
        <property type="gene ID" value="VAB18032_18660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18660"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_0_11"/>
    <dbReference type="OMA" id="RDWAGMM"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="43274" checksum="CFC5C5A6D1F583F6" modified="2011-06-28" version="1">MAFGVSELWDPAVRHDPHPFYDRVRASGGPVPQVDPAGNRLWVVAGHADVLAGLRHPEIGHEMHRRGPGGWQRRTDDLSEAARIEARQLISLDPPDHTRLRGLVSGGFTARAVARLEPWITDLADRLVARARRLGHIDAVTDLADPVPVNVIAELVGIPEPDRPQFRAWSAAIVSARPDGPAATSAFAAYLDELAAARRAAPADDLITALVVAEDRDDRLDRDELVALVQLLLIAGQETTVDLIGNGLRLMLSHPEQWQALRADPSLAAVVVEETLRFRGPVEIVPPRYAFADIELGGGRIPAYDRVGLSLWGANRDPAVFERPHEFDIHRADVGRHIAFGYGIHFCLGAHLARLESRIMFERIAQELPGLRLAVDPAQLDGFRLHHDGLPMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD14</accession>
    <name>F4FD14_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">argS</name>
        <name evidence="13" type="ordered locus">VAB18032_18720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733501.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18720"/>
    <dbReference type="EnsemblBacteria" id="AEB44846">
        <property type="protein sequence ID" value="AEB44846"/>
        <property type="gene ID" value="VAB18032_18720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18720"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_5_1_11"/>
    <dbReference type="OMA" id="HHIGDWG"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="459"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB44846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="573" mass="61798" checksum="C8BE78D5AB96DA9C" modified="2011-06-28" version="1">MTVPSLASSLSDTVSAAATSLGLADFVAQVRRSEHADFQADGVLAAARTLRRRPRDIAAEVVEALRADDLVAEVAGPGFVNLDLADRTLLTQLAGRLADPRLGVGTPETGITTVVDYSQPNIAKEMHVGHLRSTIIGDALVRILEHLGGTVVRRNHIGDWGTQFGMLIQYQNEQPVTVGGDDASMSRLAALYRQARARFDTDPQFAVRARQRVVALQGGDPNTVAAWQDIVAESTRYFTDVYARLGVRLTPADAVGESAYNDALPGVAADLAAQAVAVPSDGALCVFFDEVRGPDGAPSPLIVRKRDGGFGYAATDLAALRQRVAELHADRLLYVVDARQSLHFTMVFDTARRAGWLPPQVSAVHVAFGTVLGPDGRPFKTRAGDTVRLVDLLTEAVDRAREVVAAKNPELTGAALHERARQVGIGAVKYADLATSRTRDHTYDPQRMLALTGNTGVYLQYAHARIRSLLARAGDPAITVDPTTTLEPAERALILDLDGFADTLTEVLAHYEPHRLCGYLYRLAQTFTTFYEHCPVLRAPDPVRSNRLALCHLTGDTLHTGLSLLGIPAPTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD36</accession>
    <name>F4FD36_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734718.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24840"/>
    <dbReference type="EnsemblBacteria" id="AEB46066">
        <property type="protein sequence ID" value="AEB46066"/>
        <property type="gene ID" value="VAB18032_24840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24840"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129336_1_1_11"/>
    <dbReference type="OMA" id="FTENGSM"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="45"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="161" mass="17411" checksum="D661FBEA0507B093" modified="2011-06-28" version="1">MTTVATTTWGSAAALLAATGTREDTDYYRGFTAEDEKAVLTVPMRIQAAWAANDADAFADVFASNGSLLMGDRQLTSREEIRSYMAEAFAGGFRGARVKGWPIEVRFLTADVALVITEGGIIPPGQDQVAPQDLIRATWVVVRRSDGTLELMSHQSSPVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD77</accession>
    <name>F4FD77_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_25045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25045"/>
    <dbReference type="EnsemblBacteria" id="AEB46107">
        <property type="protein sequence ID" value="AEB46107"/>
        <property type="gene ID" value="VAB18032_25045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25045"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331463_0_0_11"/>
    <dbReference type="OMA" id="YIPWAWL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="409"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="501"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="597"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="870" mass="90640" checksum="A3EAC1FD1A7DEB90" modified="2011-06-28" version="1">MDEVVPTRTTRSRSRLRGGLVTVATVLALLAAMGLTVLGLGSADNAVASYDASSWLWSAARSELARVNGVTARVDTRVEVPAARRHPMQVVQTDRMLVLRDLHSGQISALDLATLQITATTPTTPGLGVSVALHEDAAFVVDAVQGVVRQLDPRSLTPVGEPVRYPPGITGGTFDGEGRLWIAVPAEGTVSAITAARLPASGAPDAPVSPQQVETHDVAEPSHELMVSTLDDGVAVLDRTAGALVTVVRGETRRTVLGEQLTGPGTVPARTSGPVVPVTVAGQRQVHAVADGEVRSFTVPGEGDRLGAAVAWAGRIYCADDAAGVVYAFDAAGQLVDTIRGRWGGPLELEVRENHLFINAPNAATARVVNDRHEVREVDKYANDVLGGDPPEEPPPPPPPPPRKPQVSKPGAPRSVTASAGDAQARVSWRPAAANGAEIVRYVVEGAGQRLEVGANQRSVQVEELTNGETYTFSVHAVNAKGAGPARKSNPVTPTAEVPDAPASVSAQARPDGTVVVTWPEANGQGNKIARYAVTATSAGTNAPAGESEGTELVIAAGELEYGTQYAFTVVAVNDKGAASESSPVSDTVVPFTVPGAPAELTAGTVADRPGTVSVQWAPAEANGRPVTGYVVEVGERRSEVTDTRTTVGGLGDGQNVTVRVRAVNEAGEGPEATTTARTVAPPRVTVTGSSATATSATVAFTVDAGGGQATCTLARSGQPATSGPCSSITMGGLTPGTGYTFTVTATNAAGSGTATRAQETDALYGIATCVNGDEPEQRTYCDRDRDGRNGNEIFSVPRQDNDRQVGWAKPGTRLKALCKVRGEEVYAYVYNNDKRSTWWVRVEYSGRNYIPWVWLNLEDGDNINVLPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDL8</accession>
    <name>F4FDL8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06285"/>
    <dbReference type="EnsemblBacteria" id="AEB42381">
        <property type="protein sequence ID" value="AEB42381"/>
        <property type="gene ID" value="VAB18032_06285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06285"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_8_0_11"/>
    <dbReference type="OMA" id="HDERVIT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="63"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="43429" checksum="663AC6AF1349EC42" modified="2011-06-28" version="1">MTGQPLAARVRQRIAAAATPVTPATIVSAVRAEADTAVLGDTALLRMADQVRDDLVGAGPLAPLLADPEVTDVLVNGVRVWVDRGQGLHQVPVPVGTVDDVRRLAQRLTAGAGRRLDDGSPCADARLADGTRLHAVLPPVATDGPYLSLRTFRQRPFNLDELVAQGAVPRPAAAVLAAVVSARLAYLVIGGTGSGKTTLLNTLLGLVPGTERIVLVEDAAELRPLHPHVVGLQARTANVEGQGTIGLSELVRQALRMRPDRLVVGECRGAEVVDLLAALNTGHDGGAGTLHANAPSDVPARLEALGLLGGLPRPALHAQLAAALQVVVQIRRTAQGRALESICLLLPEGPERLVRAVPAWVRGRGVGPAGPALAALIRSRDVPVPPILNEPWPGSAGPDEHLAPGAATPRDDTQPGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDN3</accession>
    <name>F4FDN3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06360"/>
    <dbReference type="EnsemblBacteria" id="AEB42396">
        <property type="protein sequence ID" value="AEB42396"/>
        <property type="gene ID" value="VAB18032_06360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06360"/>
    <dbReference type="eggNOG" id="ENOG50337X2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101787_0_0_11"/>
    <dbReference type="OMA" id="KTVPAQW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="27230" checksum="88FC3E8870166341" modified="2011-06-28" version="1">MSGSGETSAAQPLPMSFPLPAAAPPTARRPRARAVASDPTEETPAGEAPDEETRAGETRTRETRTPVGDRQLVFFGAETAEPSVADLAGLLAGPGEVHRMGGTARLSVVVDAGWRVHVLVAELAQRGVRATWTPTEDQRYAVQTAYTRAIVPLAAAWLRGPTQQPPAGFQLDGRRLRLWLAAAGVVDPPEILLHLGGVDPGRWSVVGAALTAAGLVGELVEPGAGGPAYRISGRRRVLRLAELVGEPPPAAPPGAWPVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDN8</accession>
    <name>F4FDN8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanine racemase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731074.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06385"/>
    <dbReference type="EnsemblBacteria" id="AEB42401">
        <property type="protein sequence ID" value="AEB42401"/>
        <property type="gene ID" value="VAB18032_06385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06385"/>
    <dbReference type="eggNOG" id="COG3616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042383_0_0_11"/>
    <dbReference type="OMA" id="DRVWFRH"/>
    <dbReference type="OrthoDB" id="1512472at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="42463" checksum="6C49F0FC5965A6D8" modified="2011-06-28" version="1">MATDSENLRHRLDRATRHLDPPYAVVDLTAFDANSAALVDRAGGKPLRVASKSLRCRELIARALARPGWHGVMAFTLPEAIWLVRTGVTDDVLVAYPTVDRGAIAELGADPALAAAITLMVDDPDQLDFHDTVRSPGSRAELRICLDLDASWRLLGGRVHVGVRRSPVHSAQAAGRLAAAITARPGFRLVGLMSYEAQIAGVGDAPPGQTALGAVIRLAQRGSYRELLARRAAAVAAVRDHADLEFVNGGGTGSVATTSADPAVTEVTAGSGLYGPTLFDAYRDWRPTPAAFFACAVVRRPAPGLATVLGGGWIASGSASRSRLPRPWLPAGLKLVGTEGAGEVQTPLAGRTAATLRIGDRVWFRHAKSGELCEHVNELHLVDGDEVVATVPTYRGEGHAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDR4</accession>
    <name>F4FDR4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06515"/>
    <dbReference type="EnsemblBacteria" id="AEB42427">
        <property type="protein sequence ID" value="AEB42427"/>
        <property type="gene ID" value="VAB18032_06515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06515"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_4_0_11"/>
    <dbReference type="OMA" id="RWAYETK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="96"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="32868" checksum="745DFEA48A208563" modified="2011-06-28" version="1">MTGQLPVGAGWAYEFKWDGVRALADITAGRQHLYARSGVEITAAYPELITLAEQVDDALLDGEVVLFDQAGRPSFTALAERMHVRDRAKAARLAASVPVTYMIFDLLRLRGEDLTGWPYARRREALDDLGLGAARWAVPPVFFDGAATYSAAGEHGLEGVMAKRVDSTYRPGVRSPDWVKVKLEVTGDFVVGGWRPGARRIGGLLVGVPGAGGRLTYRGRVGGGIGAAIERELLRELEPLRTPTSPFAAGVPREDARGAIWVTPQVVVEVKYGQRTPDGRLRFPRILRLRPDKPAEEVDDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDT3</accession>
    <name>F4FDT3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_12500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732283.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12500"/>
    <dbReference type="EnsemblBacteria" id="AEB43614">
        <property type="protein sequence ID" value="AEB43614"/>
        <property type="gene ID" value="VAB18032_12500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12500"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="RDRQFLG"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="36785" checksum="559228BFB4EAE601" modified="2011-06-28" version="1">MSEVVLSGVVKRYGQVTALAGVDVRVPSGKLTAVLGPSGCGKTTLLRCLAGFERIDAGEILIDDSRVAGGGRHLPAHRRNIAVVPQEGALFPHLSVADNVGYGLDRAARRSDRVEEVLTLVGLAGYGGRMPHQLSGGQQQRVAVARALAPRPSVVLLDEPFSALDAGLRAGLRHDVREALRADGATGVLVTHDQGEALSVADKVVVLRDGRVIQADAPTAIYREPVDVWVAGFVGDAVLLPAVVEQGSARTALGLLPVTGPVTDGQVTVLVRPEQVRVAAGSAGVTASVLRHDFHGHDALIGLRLADGTRITARILDGGADWPVGGQVTVHVDGPARAFPAQTASTTSVLVDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDT5</accession>
    <name>F4FDT5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_12510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12510"/>
    <dbReference type="EnsemblBacteria" id="AEB43616">
        <property type="protein sequence ID" value="AEB43616"/>
        <property type="gene ID" value="VAB18032_12510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12510"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_2_0_11"/>
    <dbReference type="OMA" id="HPYNVSL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312942" evidence="3">
        <location>
            <begin position="23"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR002825-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="352" mass="36922" checksum="9244FA10F4E081A0" modified="2011-06-28" version="1">MPATRRIARALLAASLLTVGLAACGSGEEDKATGSDQSADKQITVYSGRNEQLIKPLLDKFTEQTGIAVNARYANTAQLAAQLVEEGDKSPADVFLAQDAGALGTVAKQGMFSTLPEATTAKVPATYRAGNGQWVGVSARARVLAYNPDLVPADQLPASVFDLTGPAWKGKVGVAPTNASFQAFITAIRVQHDDAKAEEFLRGLKANDPQIRDGNGKILEDVISGAIPAGLINHYYLGEVAKEQGTTPDALKAKLHFFPGGDTGGLVNVAGVGVLKRAADNPDVQTFVDFLLGTEAQTYFAEQTYEYPVIDGAPAPAFVPALADLAVPQIDLNDLDTLDATVSMIKNSGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDV5</accession>
    <name>F4FDV5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleic acid binding, OB-fold, tRNA/helicase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732304.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12610"/>
    <dbReference type="EnsemblBacteria" id="AEB43636">
        <property type="protein sequence ID" value="AEB43636"/>
        <property type="gene ID" value="VAB18032_12610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12610"/>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144847_1_0_11"/>
    <dbReference type="OMA" id="GQEVTMI"/>
    <dbReference type="OrthoDB" id="1944256at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016499">
        <property type="entry name" value="NucleicA-bd_Rv2694c_prd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006910">
        <property type="entry name" value="NA_bind_Rv2694c_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="14176" checksum="16A40B46C152AF32" modified="2011-06-28" version="1">MTTDEGQGSLRRMLRRFTASEAEIEAQQLQQESARCGGVPVTQCMRGQVVSVTGRLRTVVYTPRTNQPALEADLYDGSDVVTLVWLGRRHITGIEPGRHLTARGRVALRDDRKVIYNPYYELEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDW2</accession>
    <name>F4FDW2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43643">
        <property type="protein sequence ID" value="AEB43643"/>
        <property type="gene ID" value="VAB18032_12645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12645"/>
    <dbReference type="eggNOG" id="ENOG5031FHE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705847_0_0_11"/>
    <dbReference type="OMA" id="PGYLVYS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="391" mass="41647" checksum="EAC0EE18A79CA051" modified="2011-06-28" version="1">MTATSLSALLVAVSACGPVAERRPQDLRVGYDSLDGSLTVWPPRGSLAEDPAATAAATRAVRDWRSPIDDRVHVPSSGILYSGQVDGTPLALVAASVPGQAASWLLQLTGDGDGYRVTHATEYTDPGYLVYSDVLPVQAADGRRYFTSERVRRLVGPNGRILSATDGLTDPVDVPECRAVTVTATLRSTTSLPRGRAADRLLDLGTGIAAPRYPLVRDESGSGRRALTGLDTCQLADKDGPFGSVTRRVGDRDTPDSVPASWPMAKVAVRTLGEVALDGGEPAELEQLTWETADGTMSAVVYRPADDTPLVYSPADRTSPLQVYELPVPGQPLVVLSWRSTKDTTLSVPPGTTRLVDRPGLVVAPLPERRQTFSLAADDKTHYRTAGPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE43</accession>
    <name>F4FE43_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VTC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733567.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19050"/>
    <dbReference type="EnsemblBacteria" id="AEB44912">
        <property type="protein sequence ID" value="AEB44912"/>
        <property type="gene ID" value="VAB18032_19050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19050"/>
    <dbReference type="eggNOG" id="COG3025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068202_0_0_11"/>
    <dbReference type="OMA" id="RVDRKYV"/>
    <dbReference type="OrthoDB" id="1375644at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="2">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="30949" checksum="B591FF91C3F6DBDC" modified="2011-06-28" version="1">MTPITAPWTELAPVGLTELVDRAALQTRVDRKYVVPLDELPDLLAQLSPYARVLDIDGVRAFRYESVYFDTPRLASYHCAAYRRRRRFKVRTRSYLDSAQCWLEVKISGARGSLTKHRLPYRPQDRATVHPGRAFVQEALEREAVCPTVDSALDPVLVTTYQRATLLLTATASRVTVDTDLTWRCGDRTLRLPDLAVVETKTSRAASVADRLLWQRGTRPVRISKYATGLAALRPELPDSPWRRTLRRHFRDSTPSTGTTPSTIARSVQEASCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE58</accession>
    <name>F4FE58_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylenetetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733582.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19125"/>
    <dbReference type="EnsemblBacteria" id="AEB44927">
        <property type="protein sequence ID" value="AEB44927"/>
        <property type="gene ID" value="VAB18032_19125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19125"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_5_3_11"/>
    <dbReference type="OMA" id="GTANPAM"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="328" mass="34812" checksum="F5C456034A35A842" modified="2011-06-28" version="1">MTDDRLVGIGLQSDKSADEYAELAELTERYGFDVLSVFGDLMYQPPIFPLLVAARHTRRIRLGAACLNPFTLHPVEVAGQVAALDLASHGRAYLGLARGTWLQEIGVAQARPLRRIAETVQIVRRLLGGDDSGFEGREFTVAPGTSLRYAPARPDVPVLVGTWGQQTARSAAGYAAEVKVGGSANPAMAKTMRAWLDEAGGDHTGVVLGAVTVVDTDGELARRVARTEVAMYLAVVAALDPTVEVDPGLLARIKEHVARREDDAAGALIGDDLLDLFAFSGTPEQVAAQAAAVFDAGASRVEFGTPHGLTPRTGIDLLGQRVLPLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEN6</accession>
    <name>F4FEN6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06530"/>
    <dbReference type="EnsemblBacteria" id="AEB42430">
        <property type="protein sequence ID" value="AEB42430"/>
        <property type="gene ID" value="VAB18032_06530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06530"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010077_0_0_11"/>
    <dbReference type="OMA" id="WGAVRYP"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307853" evidence="1">
        <location>
            <begin position="29"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="488"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="774" mass="81663" checksum="F8B870060ED13FDF" modified="2011-06-28" version="1">MTSKKTLPVLAVAGATVAALAITGTAHAGAQPHQHAGHHGPARSFDRVATYPVFQNRPAGEDPATETVAEISAVSADGRTLIYTDAAARRIGFLDISRPGKPRGLGTLSLAQLGDAEDEPTSVAVVGRYVLVVVNTSASYTDPSGRLDIIELATRKRVRSLDLGGQPDSIAISADERYAAIAIENERDEEATPPGGKKGDLPQAPAGFVQIIDLPGSNPHRWTLRTVPLTGADGRALPALAAAGIVEPTDPEPEYVTINRRNQLAVTLQENNGIVLVDLPTGRITSVFSAGTASVTRIDTAKDGVIDLTGSITDVPREPDAVAWLDDRYLATANEGDWRGGTRGWTVFDSRTGRVAWDAGNSFEWLAVRHGLHNEDRAGKKGTEPEGIAVAEYNGIRYAFVGSERSNFIAVYDVSKPTAPVFKQMLATTNGPEGLLPIPSRGLLAVSSETDEADANVRASVTLYQLGKAAPGFPSIVSGPDATGAPIGWGALGALSAAPKQPHLLYSVTDAAYAKTQIFTIDVRRNPAVIIKALPVRDERGEPVGYDAEGIFARPQGGFWLAVEGATGPGNKLVRVDAAGVTRQVVPLPADVAPGLGKQGFEGVTATTDKRGREIVWAVLQREVATDPAGVVRIGRYDVSAGTWSWFGYRLERTSVPGDSMGLSEVTVVGDRLAVIERDKLNGPAAAVKRIYTVELPTGPAALGPLRVLPKRLALDVLPALRADNGWTQEKLEGLTVAGNGQVYAITDNDGVQDATGETVLLRLGPSAKVFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEP2</accession>
    <name>F4FEP2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase domain-containing protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731109.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06560"/>
    <dbReference type="EnsemblBacteria" id="AEB42436">
        <property type="protein sequence ID" value="AEB42436"/>
        <property type="gene ID" value="VAB18032_06560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06560"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_22_0_11"/>
    <dbReference type="OMA" id="AKYEPNA"/>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="207" mass="21650" checksum="996618D99257173D" modified="2011-06-28" version="1">MPLLTVGFDLDMTLVDSRPGIAATYRALTAQTGVPVDAEAAVSRLGPPLRTEIAHWFPPEQVDEAVRVFRELYPAYAITPTVPLPGARAALDAVRERGGRVVVVTSKLGRLARLHLDHLGLAVDELAGDLFAEEKAAALREHGATYYVGDHVADMVAAKAAAVPGIAVATGPCSVDELRAAGAAAVLPDLTGFPAALDGMIRLALTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FET3</accession>
    <name>F4FET3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731150.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06765"/>
    <dbReference type="EnsemblBacteria" id="AEB42477">
        <property type="protein sequence ID" value="AEB42477"/>
        <property type="gene ID" value="VAB18032_06765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06765"/>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055269_1_0_11"/>
    <dbReference type="OMA" id="GFRHVHP"/>
    <dbReference type="OrthoDB" id="1271038at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="319" mass="32863" checksum="41BE8E5A70D46753" modified="2011-06-28" version="1">MNTATKLTGFALGLAAVFGAAYGVGQVTGPAAPVVADGHDAGPHGTAAPGQETGGHDASGAAGHLPGGLLVSDRGYTLVPVAAPEGEFAFRVSGPDGKPVTRYEVTHDKPMHLIVARRDLSGFQHVHPELAADGTWRVASPVNSPGVWRAFADFTPTGGEPLTLGVDVTVPGELTERPLSAPASSSTVHGYTVDFHGTPQPGGNTTLTFTVSRDGVPVRDLEPYLGAYGHLVALRQGDLAYLHVHPEGGPGDGSTAPGPQVRFAAEFPSAGAYRLYLDFRHDGVVRTAEFTVHVGDPGAIPSPEGVIADEHGTPGHEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEU9</accession>
    <name>F4FEU9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ECF subfamily RNA polymerase sigma-24 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_06845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06845"/>
    <dbReference type="EnsemblBacteria" id="AEB42493">
        <property type="protein sequence ID" value="AEB42493"/>
        <property type="gene ID" value="VAB18032_06845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06845"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_0_11"/>
    <dbReference type="OMA" id="QNRGRWD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="427" mass="46993" checksum="F2DEB6958AB67E4A" modified="2011-06-28" version="1">MTATDSTIDDARRATHRAVEAVWRIESARLIARLARLVSDVGLAEELAQDALVVALERWPQTGVPENPGPWLLATAKHRAIDRLRRQERYARKLALFTRDVQIRQEYAEADRDAELDDHIGDDLLRLVFTAAHPVLSGEAKVALTLRLLGGLTTPEIARAFLVPESTAAQRIVRAKRALAAANVQFELPTRAELPERLAAVLEVIYLIFNEGYAATSGPDWARPELCHEALRLGRLLAGLLPAEPEVHGLLALMELQASRLRARVDAAGQPVPLLDQDRRSWDRLLIRRGLDGLARAEALGIGSYTLQAAIAACHARATRAEQTDWPRIVALYEVLAHLQPTPVVLLNRAAAVGLAGDPKRGLSLVDELAQERSLRDYPQLPAVRGELLARLGHTGPARDEFLRAAELTRNDGERGLFRRRADGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEV4</accession>
    <name>F4FEV4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06870"/>
    <dbReference type="EnsemblBacteria" id="AEB42498">
        <property type="protein sequence ID" value="AEB42498"/>
        <property type="gene ID" value="VAB18032_06870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06870"/>
    <dbReference type="HOGENOM" id="CLU_3223540_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="44" mass="4806" checksum="887DC3C4B9FE8678" modified="2011-06-28" version="1">MQAEYDEAPVSLALYMGSCMVAACQDMGWAPAGSLHRRFLGWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF17</accession>
    <name>F4FF17_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_13075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732397.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13075"/>
    <dbReference type="EnsemblBacteria" id="AEB43729">
        <property type="protein sequence ID" value="AEB43729"/>
        <property type="gene ID" value="VAB18032_13075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13075"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="OMA" id="ISTMLEH"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="339" mass="36543" checksum="B8A8F8BCF8E3B6D8" modified="2011-06-28" version="1">MGANDNRTVTIAAIARLAGVSVPTVSRVINGRSDVAPQTRQRVEELLSRHGYRRRPPSMRASSGLVDLVFNDLDSPWAVEIIRGVEDVAHAAGVGTVVSAIHRRTSSAKQWLDNIRTRSTEGVIFVTSTLEPPQQAELRRLNIPVVIVDPAGVPSQDAPTIGATNWAGSLRATEYLIGLGHRRIGFIAGLPQLMCSRARMDGYRAALEAAGLPIDDRLIQPGNFYHEAGFAGGARLLALADPPTAIFASSDQMALGVYEAVRQRGLRMPGDISVVGFDDLPEVRWCSPPLTTVRQPLSEMGMLAARTVLRLAKGEKVESPRVELATELVIRDSAAPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF58</accession>
    <name>F4FF58_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_19305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19305"/>
    <dbReference type="EnsemblBacteria" id="AEB44963">
        <property type="protein sequence ID" value="AEB44963"/>
        <property type="gene ID" value="VAB18032_19305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19305"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_47_0_11"/>
    <dbReference type="OMA" id="ITVIIME"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="26"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="426" mass="42920" checksum="3DBD788EE2DC38FD" modified="2011-06-28" version="1">MTSVDTATAPAQPVMPGDLMTPRQRLRLILVLGSLIAVGPLTIDMYLPALPAIVDDFATSSAAVQLTLTGTLIGLALGQLLIGPLSDAVGRRAPLIAGTALHIVASVCCALAPNVTVLGALRVVQGLGAAAAAVIAMAVVRDLFTGIAFARTLSRLLLVMGAAPVLAPTLGSELLRWTQWRGVFAALAVFGVLLMLVAVLGLPETLPPAQRQRGGPLHIVRLYGGLLRDRAFVGLIMVAGLAMAALFAYVAGSSFVMQEQYGLDEQQFGLAFGAGAIGLIAATQGNVRLLRRYTPQRILLVALLAGTAAALVLVALALTGFGGLPALLAALWLVLAATGLALPNAPALALSRHGEAAGTASALLGAVQFGVGAVAAPLVGVLGNGAVAMAAVIAGGLASALIALLVVARPDQLAAVDAEPVAVALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFD2</accession>
    <name>F4FFD2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-flanked domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734886.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25680"/>
    <dbReference type="EnsemblBacteria" id="AEB46234">
        <property type="protein sequence ID" value="AEB46234"/>
        <property type="gene ID" value="VAB18032_25680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25680"/>
    <dbReference type="eggNOG" id="COG3402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104197_0_0_11"/>
    <dbReference type="OMA" id="PYGRMQY"/>
    <dbReference type="OrthoDB" id="1768296at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="91"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="19347" checksum="023982EA5CDC9AB2" modified="2011-06-28" version="1">MSGEQVGGQVPASAAGQPGPLEPWPNTVRWQSISSDLIWVELLRLSGVVVVLSIMIGVAWGFTGAWPFGLALGVVLVFAVWRAVTIVRAVRAWGYAERENDLLVRHGLLVRRLSIVPYSRMQFVDVSAGPLERAFDLATVQLHTAAAASDARVPGLRPAEASRLRDRLTALGEDRAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFH8</accession>
    <name>F4FFH8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734931.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25910"/>
    <dbReference type="EnsemblBacteria" id="AEB46280">
        <property type="protein sequence ID" value="AEB46280"/>
        <property type="gene ID" value="VAB18032_25910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25910"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_0_2_11"/>
    <dbReference type="OMA" id="PPWGPER"/>
    <dbReference type="OrthoDB" id="1668114at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="43"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="145" mass="15019" checksum="28CAE56F7138F447" modified="2011-06-28" version="1">MTEETSTPESGAVATDSAATPATDASATPAADGTAARGKAAVADVEEAMKDVVDPELGINVVDLGLVYGVHVDDENVATLDMTLTSAACPLTDVIEDQARQALTTGPGGGLVNDIRINWVWLPPWGPDKITDEGRDQLRSLGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFL1</accession>
    <name>F4FFL1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase sdr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736122.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02020"/>
    <dbReference type="EnsemblBacteria" id="AEB47488">
        <property type="protein sequence ID" value="AEB47488"/>
        <property type="gene ID" value="VAB18032_02020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02020"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_14_1_11"/>
    <dbReference type="OMA" id="PADVTGY"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="32807" checksum="4804B4B84C0E3636" modified="2011-06-28" version="1">MTKPLTATVALVAGATRGAGRQIAVQLGAAGATVYTTGRSSRAGRSELDRPETIEETAELVTAAGGTGIAVRVDHLVPDQVRDLIARIDTEQGRLDVLVNDVWGADPLITWEKPVWEQPLDAGFRTLRLAVDTHIITSHFAMPLLIRRPGGLVVEIGDGTRAYNEQNYRLSVFYDLAKTSVNRLAFSWAHELRPYGGTAVALSPGWLRSEAMLEHFGVTEANWRDGAAKDPHFLISETPAFVGRAVAALAADPDRARWSGHSVSAGDLAKVYGFTDVDGSQPDAYRYITEVVDAGKPADVTGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFL6</accession>
    <name>F4FFL6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736127.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02045"/>
    <dbReference type="EnsemblBacteria" id="AEB47493">
        <property type="protein sequence ID" value="AEB47493"/>
        <property type="gene ID" value="VAB18032_02045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02045"/>
    <dbReference type="eggNOG" id="ENOG502ZE8V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093810_0_0_11"/>
    <dbReference type="OMA" id="HGEQTVR"/>
    <dbReference type="OrthoDB" id="2024969at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="31415" checksum="43C933855A118BA4" modified="2011-06-28" version="1">MTQPKTNRIPAPIYAAAGAGDLALEQLRKLPTVVAELRERVASDGSRVANDLGGKAVVAGFELRQKANEKLRNANLTAESLRRNADLNRLREAADLKRLREAADLNRLREAADLDRLREVADFNRLREAADLDRLRESADFNRLRQAADLDRLRGLAARNAAVVVAGAHAAQERALAVYSKLVTRGERAVGTGVLEAADTVNADIEATQASVQAAPATTEAAATTEMATTKKPAASVESAEVPSPAEVAEIAQAKPAAAKKATRAKATTRQPAAKRTATPSAKLPGATKRTRPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFR5</accession>
    <name>F4FFR5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736175.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02290"/>
    <dbReference type="EnsemblBacteria" id="AEB47542">
        <property type="protein sequence ID" value="AEB47542"/>
        <property type="gene ID" value="VAB18032_02290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02290"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043786_0_0_11"/>
    <dbReference type="OMA" id="WNASEND"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="37084" checksum="E49365A26C0A727B" modified="2011-06-28" version="1">MDIAVAPFDPSDEAALDDAYRIRAAAQVVDTPDVPAGDRAEFGLVAAHPPYGNLIHRALARRGGEAVGYLWLRLPQLDNTSTVLVELFVDPAHRRRGVGRALLAHAREVALGHGRKHLIAEVDGVPPGEDRQPPGAAFAAAVGAQAALPMVRRRLDTTGLDEAALTALHEQARSRAAGYRTVAWQGAAPEEYVADVARLEARLLVDAPTGDLAMEAERVDAARIREIERFQALRGRRRYHLGAVHEQTGRLVAWTMIQTGPFTNWYASQEITIVDPAHRGHRLGLLVKIENLRQVLAQEPELRVIDTWNAAVNDHMVNINEQLGYRVAESAADWQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFT8</accession>
    <name>F4FFT8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06970"/>
    <dbReference type="EnsemblBacteria" id="AEB42518">
        <property type="protein sequence ID" value="AEB42518"/>
        <property type="gene ID" value="VAB18032_06970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06970"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_3_2_11"/>
    <dbReference type="OMA" id="HAMAPDL"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="12"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="21601" checksum="F8F1A9928175BEC8" modified="2011-06-28" version="1">MTDRSSLVETTLLLGSPRAGSRTSGIALRLMEELALALGTEGVETAGPDIVDLADIGAALPQRASRSVPLGPEIERALGLVRRPGLLVVVSPTFKGTYTGLLKLFLDMLPMDGLADCVAVGAMTAGWAKHRGAGDQYLRPLLTELGATAPVPCLSILEDEFEDVPEVVATWSRRWAPTLGAVVRHQRHCFSAPRVPPLTGARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG17</accession>
    <name>F4FG17_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4236 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732429.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13235"/>
    <dbReference type="EnsemblBacteria" id="AEB43761">
        <property type="protein sequence ID" value="AEB43761"/>
        <property type="gene ID" value="VAB18032_13235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13235"/>
    <dbReference type="eggNOG" id="ENOG502ZD6P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208380_0_0_11"/>
    <dbReference type="OMA" id="GPLILNF"/>
    <dbReference type="OrthoDB" id="2028106at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025330">
        <property type="entry name" value="DUF4236"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14020">
        <property type="entry name" value="DUF4236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4236" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="59" mass="6891" checksum="6C14247BBFF20EBC" modified="2011-06-28" version="1">MGLMFRKRKKFGPLILNFTQNGFSSWSIKLGRWSWNSRAKAHRVDLPGPLSWKQDKSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG20</accession>
    <name>F4FG20_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix, arac domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13250"/>
    <dbReference type="EnsemblBacteria" id="AEB43764">
        <property type="protein sequence ID" value="AEB43764"/>
        <property type="gene ID" value="VAB18032_13250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13250"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_11"/>
    <dbReference type="OMA" id="HKHDFFI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="32918" checksum="C602D8720474F00E" modified="2011-06-28" version="1">MVASGHLSPARLDPTGEIETVTLCSLAPDPRWRRPMLLDRELIVLATSGHGYAEVDFRPLPCRPGTLLRVRPGQVLRCALPDLDATVIRWHPEALHGLDVAADDGPAWFQLAGEDEDAVINEVSQLTVDARRHRDTPAGRSLLRHQLSVLLLRLSMLPNADWRPSRPEEVTYHRFRREVEIGFSHSRRVEDYADRLGCSVRTLTRACLAVTGRSAKQVLDERVALQAGRLLAATDEPIAQIGRQLGFTEPTNFGRFFTREVGVSPGSFRAARDQRGPGPMVRPRTPVDARTDSHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG55</accession>
    <name>F4FG55_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="6" type="ordered locus">VAB18032_13435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13435"/>
    <dbReference type="EnsemblBacteria" id="AEB43799">
        <property type="protein sequence ID" value="AEB43799"/>
        <property type="gene ID" value="VAB18032_13435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13435"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072144_1_0_11"/>
    <dbReference type="OMA" id="TQEDAQH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="3"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="201" mass="21563" checksum="B844F4102E247939" modified="2011-06-28" version="1">MGGPVGSGKTAIIETVVPRLVEQGLRVLVITNDVVTTEDAKHVRRALTGVLVEERIVGVETGACPHTAVREDPSMNLAAVEDMEAKFPDSDVVLIESGGDNLTLTFSPALVDYFIYVIDVAAGDKIPRKNGPGISKSDILVINKTDLAPYVDADLDVMARDAELMRNGKPFVFTNCKTGAGIDELVDLVRRNVLFDAEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGV6</accession>
    <name>F4FGV6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736248.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02660"/>
    <dbReference type="EnsemblBacteria" id="AEB47616">
        <property type="protein sequence ID" value="AEB47616"/>
        <property type="gene ID" value="VAB18032_02660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02660"/>
    <dbReference type="eggNOG" id="ENOG503304R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075791_1_1_11"/>
    <dbReference type="OMA" id="PEIYWRR"/>
    <dbReference type="OrthoDB" id="1708231at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="240" mass="24476" checksum="C6FC453DFEDB8330" modified="2011-06-28" version="1">MRLTVGPLPPAVYWRRRAVVLGAVLLFLIVLLYSCNGPRGGNDATGGNQPDPGVSGTPEPTGSVLTPQTGSPPPSSGDAGAGPATPTETPGPGSSLTNNPPAVAPVADEGTCTDAELSVTAVALPAKVVRGASVDLHLKVRNRADRTCNRDVGATAQEIYIKSGAEVVWSSDTCGTAAGSDVQSFTSGFERSYQVGWNGKDSSRCANGLASGETPPAGTYEVFARVGTKLSQPVKLVLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH91</accession>
    <name>F4FH91_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13785"/>
    <dbReference type="EnsemblBacteria" id="AEB43869">
        <property type="protein sequence ID" value="AEB43869"/>
        <property type="gene ID" value="VAB18032_13785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13785"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OMA" id="GFMETAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="25680" checksum="E0BB4F0B62B58058" modified="2011-06-28" version="1">MSAPAVPPSTVVLVSGGSRGLGLAIVTDLLDAGLRVAAFARTVTPELAKLADTHPGRTHVGSVDVTDLAAVQAFVRAAEQHLGPIDGLVNNAAVGQDSLHVHTATADLAGIVETNLTAPLQLTRLVVRRMLAQGRRGRIVNITSICGQRGFPGLVAYSATKGGMDAATRSLARELGGRVLVNAVAPGFFASEMSAVLGRTQLDQIVRRTPTGHLTEPDEVLPVVRMLLREQTNINGQVLVVDGAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHE9</accession>
    <name>F4FHE9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20095"/>
    <dbReference type="EnsemblBacteria" id="AEB45121">
        <property type="protein sequence ID" value="AEB45121"/>
        <property type="gene ID" value="VAB18032_20095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20095"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="VVFQFGQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="26685" checksum="82CB7697FCFFE7BE" modified="2011-06-28" version="1">MSAPILHAEHIEKWYGPTAALRDVSVSIDKGEIVAVTGPSGCGKSTLLHCLSGILAPQRGSVRFQGRDIGTAGEAERSRLRRTVFGVLFQFGQVVPELTGIENVTLPLQLGGHSYRDAAVRAQALLDRLGVGDLAGKRPGEMSGGQQQRVALARALVTEPQVLFADEPTGALDSLAGEQVMVELVRLAREHGTTVLVVTHNAQVAAYADREITMRDGRVDSDGRSDSYGPDDGGGGRGDGDRRVVLRGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHG7</accession>
    <name>F4FHG7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45139">
        <property type="protein sequence ID" value="AEB45139"/>
        <property type="gene ID" value="VAB18032_20195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20195"/>
    <dbReference type="eggNOG" id="ENOG5033IKU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122719_0_0_11"/>
    <dbReference type="OMA" id="WTAPRQQ"/>
    <dbReference type="OrthoDB" id="2092400at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="30799" checksum="50C64EAE8DF16C55" modified="2011-06-28" version="1">MATRHSSAQAVAEGERTDKRRELLIMNEGSPGAPAERTWRWWPALRLALVLLWLLAAMTTWWTAPRQQGYEQARADAAAGRITAYQWGDRWDASSPPRWFDTPALHSSGTLGPLFAWRTPDGRRHWTDTDRFDQVTITDTVDNGSYSGPGAIGVAQDLRASGLEHRAGALHLPTPVVIWAGLVLAAISVGVVVAGPAPVRGTRWFWFWLISITPYGLGLLYWWAREHPWSTSATPAGHVNRRDRGILGLGLGILASILISLVLLALHTALGDRWAPQPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHI7</accession>
    <name>F4FHI7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20295"/>
    <dbReference type="EnsemblBacteria" id="AEB45159">
        <property type="protein sequence ID" value="AEB45159"/>
        <property type="gene ID" value="VAB18032_20295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20295"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061789_2_0_11"/>
    <dbReference type="OMA" id="ILHGPLY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="65"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="31930" checksum="592AAF5755C34AFD" modified="2011-06-28" version="1">MLSRYAAVAQTMGHMDPQAREIVDYYTLRYREDLRLSAGRPQARLERQRTLEILRESLPPAPARILDVGGATGEYARALVALGHRVRLLDLVPAHVAQARAGHPGLDAEVADARALPEDDDSYDATLLLGPLYHLPEHADRCTALAEAVRVTRPGGTVFAAAISRFALPLDFAATGRLDDRTIERARTLLTDGRNDPVLGFTHAYFHRLEELVDECLTAGLVNVTVEGVEGPAWLAAEAGAHGPTAEQLFTAALALARTYHDEPALVATSAHLLARATVPGDPSRTRPNQPDLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHT7</accession>
    <name>F4FHT7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_26916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735107.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26916"/>
    <dbReference type="EnsemblBacteria" id="AEB46456">
        <property type="protein sequence ID" value="AEB46456"/>
        <property type="gene ID" value="VAB18032_26916"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26916"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026357_0_0_11"/>
    <dbReference type="OMA" id="HRPECAW"/>
    <dbReference type="OrthoDB" id="658705at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="31"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="573" mass="59924" checksum="D0E70703B0DD36A4" modified="2011-06-28" version="1">MSAATRTLLLWCPDWPVLAAEIIDGVPATGPVAVLHANRVLACSEQARAEGVRRGLRRREAQGRCPGLTVVDHDPGRDARAFEPVVAAVEEVAAGVEVVRPGACALPARGPSRYLGGEEAAAERIVEHVAQSCAVESQVGVADGVFAAGLAARQGRIVPPGGTPEFLAAQPVEALGRPALADLLRRLGVRTLGDFAALSAGDVLARFGFDGALAHRMAAGRDDRPLAVRRPPVDLTVTTDLDEPIERVDVAAFAARTLAERLHERLAGHGLACTRLGIEAVTAHGQELHRVWRHDGLLSAAAIADRVRWQLDGWLTGARRGGPARPTAGIIRLRLVPDGLLAQAGLQPGLWGETGEERERAHRALSRVQGLLGPEAVVTAVLGGGRSPADQVRLVPWGDERLPARPGATPLPAPPDAAPLPARPGAAPLPARPGDAPSAARSGAVPLADRPDAPLPSWPGRLPPPSPAVVLPTALAVQVWDAAGGPVTVSARLAMSAPPARLSIDATAEAPVPVGVGRGAEIVGWAGPWPVDERWWAPAEARRRARFQVCLADGTALLLAVEHGRWLLEAIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI41</accession>
    <name>F4FI41_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sigma70_r4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30209"/>
    <dbReference type="EnsemblBacteria" id="AEB48005">
        <property type="protein sequence ID" value="AEB48005"/>
        <property type="gene ID" value="VAB18032_30209"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30209"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992632_0_0_11"/>
    <dbReference type="OMA" id="IHQIRHT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="1">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="28129" checksum="416B72DD7555F78A" modified="2011-06-28" version="1">MIDDHQMTIAELSRERREIFEGLLHDGMTQLQIAEALGMSRSRVSQLLSAGLRPERALLGAGRLTVAIGGKHETGRADGKPLAVLSAEALAAYDRIAELARSVGLSADHEIVPPPGMVNLNRPNLIVLTSPRLLPFVGQVLEADEHLGFAVDERGWYLIDKNAGKEYRSPSDSGESMDFAYIGRLPRPDGKGTFLYLAGIHGPGTAGAAHYLEGHLADIYREVRGRRWSALVGCRFDATSRQIITSELLTPIFRHEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F119</accession>
    <name>F4F119_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07765"/>
    <dbReference type="EnsemblBacteria" id="AEB42673">
        <property type="protein sequence ID" value="AEB42673"/>
        <property type="gene ID" value="VAB18032_07765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07765"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_11"/>
    <dbReference type="OMA" id="EIVMIMP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="57"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="27488" checksum="3BEBFD012864E82F" modified="2011-06-28" version="1">MHAASNGTYGAPRIHAELAAVGRRHGRKRIARRMREAGVRGRSPRRWKTTTIADPNAWQRPDLVERDFTVDATAVDTRWCGDITYINTWEGWLYLATVIDLASRRVVGWAVADHLKTDLVDAALSDALQRRRPADGLVFHSDRGCQYTSAQHARLAKRHGVRLSVGRRGQCWDNAVAESFFSTLKTELIHRQAWPTHKAAQQATFEYIEGWYNTRRRHSSLGYLSPAAYEGGTTISLLPALKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F137</accession>
    <name>F4F137_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07865"/>
    <dbReference type="EnsemblBacteria" id="AEB42691">
        <property type="protein sequence ID" value="AEB42691"/>
        <property type="gene ID" value="VAB18032_07865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07865"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OMA" id="IWIPGIR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="37569" checksum="03CA57005D89A1FC" modified="2011-06-28" version="1">MVGMQSSQHLREGAIKQLRHTREQPLVVAVEWGVDVEALRTFVAVAEAGQFQAAADELGISQQAASKRIAVLEKSLGVALLVRTSRGSRLSLDGQVFLPYAKKVLTAVEQAEQAVRPGVRPLRVDVLNRRIAPAQAVYRFYRSRPEADLDAVTLAEENAEQAARAVLEGTIDASFRALPADQVPAGISAERLLDSPLELLVGPSHPLAGTAWVRPTDLAGHRIWIPGIRPGTEWAQFYRSLSQAFGLSIDALGPNFGDEALMDALADSASLATLVGSEDRYLWPQSYYLRRIPLRKPTPLYPHVLLTRTGDQHPVLTALRDHLRAARPRTTDDVWVPDWVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1A4</accession>
    <name>F4F1A4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732607.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14140"/>
    <dbReference type="EnsemblBacteria" id="AEB43940">
        <property type="protein sequence ID" value="AEB43940"/>
        <property type="gene ID" value="VAB18032_14140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14140"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_4_0_11"/>
    <dbReference type="OMA" id="QWRSNVF"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023907">
        <property type="entry name" value="Non-F420_Flavin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03885">
        <property type="entry name" value="flavin_revert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="35108" checksum="39D50AC8C709F143" modified="2011-06-28" version="1">MTAIAFHASHEQIHPRALLEAVCHAEQVGFDAAMCSDHFAPWSERQGHSGFAWSWLGAALQATGLSFGVVNAPGQRYHPAIIAQAIGTLAAMYPGRFWAALGSGEAANEHVTGDAWPRKDVRNARLRECVDIIRALLAGDEVSHDGLVRVDRARLWTRPEQPPALVGAAVSVETARWCAEWADGLITVNAPTEHLRRMIDAYREAGGRGPVHLQVHLSWANTQAEAEAIAYDQWRSNVFAPPVCWDLATPEHFDVVSAQVPMARLAEVVNISADLGRHTGWLEDYIELGFDQIALHHVGQDQRPFLDAFGTQVLPKLAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1E2</accession>
    <name>F4F1E2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_14330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GmhB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14330"/>
    <dbReference type="EnsemblBacteria" id="AEB43978">
        <property type="protein sequence ID" value="AEB43978"/>
        <property type="gene ID" value="VAB18032_14330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14330"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518416_0_0_11"/>
    <dbReference type="OMA" id="TVPFGQW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="538" mass="55374" checksum="46467E2BC5353307" modified="2011-06-28" version="1">MLAGAGPVGRESPLFDAVLLDRDGTLIEDVPYNGDPDKVRAMPGARAALDRLRAAGLKLAVVTNQSGLARGLFTEAQLDRVHRRVEELLGPFDSWQVCPHDDGDGCACRKPAPGLVHAAAEALGTVPARCALIGDIGRDITAALAAGAAGILVPTPVTRTEEIAAAPWVADDLPSAVAEILRRQQALTPATTATRVEAERTVLVVRSDSAGDVLVTGPGIRAVAAGADRVVLLCGPHGRAAADLLPGVDEVIEHRLPWIDPAPGPVDPAEMTTLIARLAAVAADEAVVFTSFHQSPLPLALLLRMAGVARIAAISDDYPGSLLDVRHRVPAGVPEAERALSLAAAAGYPLPPGDEPRLRLRPAPPPPPEAGEPGYVVLHPGSAAQARGCPPELAERISRELVDAGHRVVVTGGPQERDLTARVAGAHAVDLGGRTGLAELSGVVAAAGAVVVGNTGPAHLAAAHEVPVVSLFAPTVPFGQWGPWRVPTVRLGDATAACRDTRAARCPVPGHPCLSRVEPEAVLTALRLLAVPSGGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1I7</accession>
    <name>F4F1I7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase, subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_20580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733870.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20580"/>
    <dbReference type="EnsemblBacteria" id="AEB45216">
        <property type="protein sequence ID" value="AEB45216"/>
        <property type="gene ID" value="VAB18032_20580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20580"/>
    <dbReference type="eggNOG" id="COG1294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049294_0_1_11"/>
    <dbReference type="OMA" id="FLWGVAF"/>
    <dbReference type="OrthoDB" id="761975at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="35887" checksum="E15474CF494448E9" modified="2011-06-28" version="1">MELTTIWFLLVAVLFTGYFILEGFDFGVGMLLPVLGRDDRERRVMINTIGPVWDGNEVWLITAGGAMFAAFPEWYATLFSGFYLPLLLILLALIVRGVAFEYRHKRPEASWKRRWDAAIFFGSLIPAILWGVAFANILRGVPLTADHEYAGGLFNLLNPYALLGGATTAALFLTHGAVFIALKTVGDIRDRAAALAVRLGVGTAVLAVAFLSWTLTIRSSTAAVVFAVGAALALLGGLAAAKVRREGWAFTGTAVAIALAVATLFAALFPNVLPSTLDPAGTLTAVNAASTPYTLKIMTWVAVIFTPIVLAYQGWTYWVFRKRIGVAHIPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1M2</accession>
    <name>F4F1M2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ordered locus">VAB18032_20755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20755"/>
    <dbReference type="EnsemblBacteria" id="AEB45251">
        <property type="protein sequence ID" value="AEB45251"/>
        <property type="gene ID" value="VAB18032_20755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20755"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_1_2_11"/>
    <dbReference type="OMA" id="RAFSYNV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="18226" checksum="8A2C29F176E78673" modified="2011-06-28" version="1">MRDIRIIGDPVLRTPSEPITSFDAELRSLVTDLMDTLLGKPGRAGVAAPQIGVNAQVFVYDADGHRGHMINPTLDLSDELQDDDEGCLSIPGLYFPTPRALHATAHGFDQHGEPLTIAGSGFLARALQHETDHLHGRLYVDTLRGDIRRRALREIRAGRFDSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1T3</accession>
    <name>F4F1T3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735158.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27176"/>
    <dbReference type="EnsemblBacteria" id="AEB46508">
        <property type="protein sequence ID" value="AEB46508"/>
        <property type="gene ID" value="VAB18032_27176"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27176"/>
    <dbReference type="eggNOG" id="COG3688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044346_0_0_11"/>
    <dbReference type="OMA" id="KFAGNAM"/>
    <dbReference type="OrthoDB" id="1111809at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="500" mass="53080" checksum="77FEF57ECC5E968F" modified="2011-06-28" version="1">MPLTEPHDDNLSQEEQVVAVPAAGDLADVAAAGGLGDPQTSAEGGADAGTADEQTAADPDAEQTPEPEPSLPEPVRQRIVSLTAAVLPGLPGDEVPVPLRRVAKFAPNRRARLGAPVIAAQLAADPLFRQRVTARVLADAGDLGAAVVDGTAPAAADPVEVAALAYLARPRGWRQLIDASGAAVRAEADTAVVAELVRQAEQRANRADHDRAVARVEADKLRDELARVREELGQLREESRQLARTLRESQARERRASELLATERGRAARAAADADAELRRARARLAEAEAAAGVARASAKEARSVDDARLWLLLETIGQAAVGLRRELALDPVEKLPADFVADSFADSSTATSTGAAARARDTDDPARLDQLLALPRAHLVVDGYNVTKRGFGEMSLEQQRKRLITGLGGIAAQTGDEVTVVFDGAERMHGLPPTPRGVRVLFSRKGETADELIRRLVRAEPPGRPVVVVSSDREVADGVRRHGAYPLGADSLLRRLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1U3</accession>
    <name>F4F1U3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_27226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27226"/>
    <dbReference type="EnsemblBacteria" id="AEB46518">
        <property type="protein sequence ID" value="AEB46518"/>
        <property type="gene ID" value="VAB18032_27226"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27226"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044071_1_1_11"/>
    <dbReference type="OMA" id="SIYWWGS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
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            <begin position="1"/>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AEB46518.1"/>
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    </evidence>
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        <source>
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    <sequence length="180" mass="20427" checksum="2DB579FED0C30151" modified="2011-06-28" version="1">MVSVGTIVWLSSELMFFAALFAMYFSIRAAAPEQWEKHTAVLNVPYATTFTLILVLSSITCQIGVFAAERGDVHALRRWFTITFVMGLIFVMGQANEYRELVHHGIKINEDGYGSMFYLTTGFHGLHVIGGLIAFVIFMIRTTMGRFTPAQATSAIVVSYYWHFVDVVWIGLYAMIYWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
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                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
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            <dbReference type="PubMed" id="21551311"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
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            <dbReference type="PubMed" id="21551311"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="6621" checksum="54513082E0F80A5E" modified="2011-06-28" version="1">MAWTTPRLDPDRSRRRLQLLAQLADARAIRERERPQRARTERLRELIATRRRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
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                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
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            </authorList>
            <dbReference type="PubMed" id="21551311"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="14653" checksum="57BA97455DEF1615" modified="2011-06-28" version="1">MDVQALRARADELMAQFERMRSGVGDLQQQLKAVQATVTSEDGLVTVTVGPRGQVTKVEFDSRIYRRPNSKELSATVTETIHRATAKAMADVERLMRPYVPDSQFQAYIDHDLDGIFRQLDSDLPGEDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F241</accession>
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        <submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
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                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
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            </authorList>
            <dbReference type="PubMed" id="21551311"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
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        <property type="gene ID" value="VAB18032_08060"/>
    </dbReference>
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    <dbReference type="OMA" id="QVVWHEW"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
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        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="17931" checksum="D6F454ACB980BD51" modified="2011-06-28" version="1">MTDPDAADELREAAQRGAGEVTATVIVNAPAEQVFAALLAWERQSEWIPFTTVRVVEGDGGEGSLVEAVTTLGPTVLRDRMRVVRVDAPYEIGVVHCGTLLRGPGVLRCTPLASGRSQVVWHEWFHLPGGPAGRVAWPVLWPGSKFGLTQALRRFARQVEQGRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F247</accession>
    <name>F4F247_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_08090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731408.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08090"/>
    <dbReference type="EnsemblBacteria" id="AEB42736">
        <property type="protein sequence ID" value="AEB42736"/>
        <property type="gene ID" value="VAB18032_08090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08090"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_11"/>
    <dbReference type="OMA" id="EKSWAFW"/>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="6">
        <location>
            <begin position="334"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="488" mass="50531" checksum="A5468429B146717E" modified="2011-06-28" version="1">MLAIRLIAEPDQLDAVALPLRPGAAADASAAPVPTAVALPAEVADEAAALASMIRLTGRAGEAHRQLRPGAAPARLLLVGIGDGDEPGWRSAGAALARAGKDETHITVALPVGVSAEAVRGLVEGLLLASYRYRLGADAEAPALTGVDLAVAEPEAYQQALEVARTTATMTRLARDLTNTPSSVKNPQWFADQVAAAATDLPGLRLRVREPEELAAEGFGGILAVGGGSASGPRLVELDWQPAEASTHVVLVGKGITFDTGGISIKPVPAMKLMRKDMAGAAAVVAATLGAAALQLPVRITALAPLAENMVSGAAFRPGDIIRHYGGLTSETTNSDAEGRLVLADALAYAVAELKPDLLIDLATLTGANAIALGTRTGALYSDNDQLADDVLAAVAEAGEAAWRMPLPTDYVEHLGSELADLHSAPTQGGGSVLAALYLREFTGELREKWLHIDMSAPSWCERDDAELTRGATGWGVRGLLRWLATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F295</accession>
    <name>F4F295_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine/O-acetylserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_08330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731455.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08330"/>
    <dbReference type="EnsemblBacteria" id="AEB42784">
        <property type="protein sequence ID" value="AEB42784"/>
        <property type="gene ID" value="VAB18032_08330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08330"/>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_11"/>
    <dbReference type="OMA" id="TYTLFAH"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="440" mass="47548" checksum="3D9986D1C38D32EA" modified="2011-06-28" version="1">MTEQPNRIEEAHEFGFETRQLHAGQRPDPNTGARAVPIFQTTSYVFEDPESAAAYFNLQEYGNTYSRIMNPTVAVFEERIANLEGGAGGVAFSSGIAAQAAALFTLLEPGDHVVASAALYGGTVNQLKHLLRKMNVELSWVDPDDPEAWRKAVRPNTKAFFGETIGNPGGNVLDIETVAGIAHEHELPMVVDNTFATPYLCRPIEWGADIVVHSATKFIGGHGTSIGGVVVEAGTFNWSNGRFPVIADPSPAYHGLQFHETFGTYGYLMKLRAETLRDLGGALAPFNAFLFLQGLETLSLRMERHVANARRVASFLESHPLASNVTYPGLPGSRYQPLVAKYLPRGPGAVFSFDCAGGRDGGQNLIRGVTLWSHLANVGDAKSLIIHPASTTHRQLSDDELRAAGVGPGTVRLSVGTESVEDLIWDLEQAFEHVAAAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2C5</accession>
    <name>F4F2C5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mscs mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_14425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732664.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14425"/>
    <dbReference type="EnsemblBacteria" id="AEB43997">
        <property type="protein sequence ID" value="AEB43997"/>
        <property type="gene ID" value="VAB18032_14425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14425"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021080_1_1_11"/>
    <dbReference type="OMA" id="MPVSYFT"/>
    <dbReference type="OrthoDB" id="1597438at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="396" mass="43272" checksum="A2756E53D7DCC250" modified="2011-06-28" version="1">MHSYLVTVVAALVAAAAAVVVVEVVHRLIGRWGRRSVLLTELAEHAHRAAQVTATVLSVQFAVRFSTGYAVDATWRRVLLHLLVLAVIAAGAWLVAALLVVVEDTALARFRVDVPDNRHARRVRTQVVMLRRVTIVVIVILTLGVMLMTFPAVRGIGAGVLTSAGVVGIVAALAAQSLLGNLFAGLQLAFSDAVRLDDVVVVEGEWGRIEELTLSYVVVQIWDDRRLILPTSYFTSTPFQNWTRTEAAVLGTAEFEVDWSVPVQAMREELRRLVEGTDLWDGRVCVLQVTDATGGMIKIRALVSAASAGALWDLRCLVREHLVAWVRDQRPTAMPRLRAEVGDGAGTLPWQWVRPARAPRRRSDVPDDARLFGGSDDGEARSEAFVGPDEPAEARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F325</accession>
    <name>F4F325_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03610"/>
    <dbReference type="EnsemblBacteria" id="AEB47804">
        <property type="protein sequence ID" value="AEB47804"/>
        <property type="gene ID" value="VAB18032_03610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03610"/>
    <dbReference type="eggNOG" id="COG1785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352234_0_0_11"/>
    <dbReference type="OMA" id="ERNTMRM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307631" evidence="1">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="199" mass="19656" checksum="3C479F26B8AFD371" modified="2011-06-28" version="1">MGAAGALLAGSVAAGSPVFAAPGDSADVSVTVDIEEIKEPGVLAMSIAGDSVTLAEDGSTLLVRQFVGTLPTVTVTDTRTPDEVPAGAAWAVLGSATDFVGGAGQAPIGAGHLGWKPKLIDGGDSGLVSEGEEVVTVVDEPTQPGNNVGLVDQELLVSTFDSGAVAGGAYAVNADLFLRTPADVAAGAYTSTLTLSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F337</accession>
    <name>F4F337_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736448.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03670"/>
    <dbReference type="EnsemblBacteria" id="AEB47816">
        <property type="protein sequence ID" value="AEB47816"/>
        <property type="gene ID" value="VAB18032_03670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03670"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060907_0_0_11"/>
    <dbReference type="OMA" id="KMNVQTL"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="376" mass="38461" checksum="58D61C8948474F3A" modified="2011-06-28" version="1">MFLAIRELTFARGRFALMGVVVALIAILTVLLSGLSVGLVNDGVSGLKRLPVTSLAFQHEVAKDSAFSRSVVDTSAVDTWAAQNGVAEAAPLGNTLANGRTNQGVEVDLALFGVEVGSFLDPAVAEGQRLAGEGEVVISSTAAELGISVGDTIALEPAGTPLKVVGILGEQHTFGHVDIGYLPLRSWQEVKAGVRAGDAAPERIYNEITAVAVRAADGADVDLAAGDKAAGTTSLTLEQSFGASPGYTAETSTLQLIQVFLYAISALVVGAFFTVLTVQRKQEIAVIRALGASTRYLLRDSLLQSVVLLVLSAGVGVAIGVAAGVGISATPMPFVLEAAPIAVATALLLILGVVGATVAVLRITRVDPLTALGGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3C3</accession>
    <name>F4F3C3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Adenosine deaminase</fullName>
            <ecNumber evidence="1 3">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 3">Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">add</name>
        <name evidence="5" type="ordered locus">VAB18032_08645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:28190"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="1 3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731518.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08645"/>
    <dbReference type="EnsemblBacteria" id="AEB42847">
        <property type="protein sequence ID" value="AEB42847"/>
        <property type="gene ID" value="VAB18032_08645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08645"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_0_0_11"/>
    <dbReference type="OMA" id="NHFTIHA"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046936">
        <property type="term" value="F:2'-deoxyadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00540">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028893">
        <property type="entry name" value="A_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="359" mass="39358" checksum="1A5382534D3BDB48" modified="2011-06-28" version="1">MATTLRYEDIVKAPKALLHDHLDGGLRPATIIELAAEVGHPLPTTDPQELARWFVAAADSGSLERYLETFAHTVAVMQTASSLRRVARECALDLAADGVVYAEVRFAPEQHLERDLSLDEVVEAVLAGFVEGSALAAEAGTPIRVGTLLTAMRHAARSQEIAELAVRHRDHGVVGFDIAGAEAGFPPTRHLDAFEYLQRENFHFTIHAGEAFGLPSIWQAIQWCGADRLGHGVRIVDDITPGPEPVLGRLAAYVRDKRIPLELCPSSNVQTGAAPSIAEHPIGLLRDLRFRVTVNTDNRLMSGTSVSREMALLCDAFGYGWREVQWFTINAMKSAFIPFDERLQIIDEVIKPAYAKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3H5</accession>
    <name>F4F3H5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ordered locus">VAB18032_14855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732750.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14855"/>
    <dbReference type="EnsemblBacteria" id="AEB44083">
        <property type="protein sequence ID" value="AEB44083"/>
        <property type="gene ID" value="VAB18032_14855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14855"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_4_1_11"/>
    <dbReference type="OMA" id="TDWDPGP"/>
    <dbReference type="OrthoDB" id="708179at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="398" mass="43718" checksum="3ADC9DA31D739195" modified="2011-06-28" version="1">MFDELDLGHDEQDRGDKGKHRRGRKRGGRSGGGRGKTALALLLALVLLGGIGGGAFYGFDRVQSYFVTPDYDGAGTEEVTIQIPQGAFLADMAVALYDAGVIKSTKAFIEAAEKNSRSRNIQSGTYKLRKQMSGELALAAMLDPASRIVNGITIPEGRTAKSIFKLLSDKTDIPVKEFEAAAKDPEKLGVPDWWFKRDDGKKSKKSIEGFLFPDTYEIPPNATAETILGQMVDHFLSVTGEMEFADRVQKDRKISPYEALIVASLAQAEAGNAEDLGKIARVAYNRAYSGNFPCNCLEFDVSVNYYWELTGKKTKSSKEMRREEIRDPKNPYSTHSHPGLTPTPINNPGKQALEGAMDPPKGDWLFFVAIDKEGRSAFAETNAEHERNVAKAKENGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3T0</accession>
    <name>F4F3T0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21405"/>
    <dbReference type="EnsemblBacteria" id="AEB45381">
        <property type="protein sequence ID" value="AEB45381"/>
        <property type="gene ID" value="VAB18032_21405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21405"/>
    <dbReference type="eggNOG" id="COG3613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052428_0_0_11"/>
    <dbReference type="OMA" id="NGRFERW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="31101" checksum="E4A44AB152580C85" modified="2011-06-28" version="1">MGPTSCTDRLTTRIAELHYAVSMGEGNDRPASRECFVIAPIGPEGSDTRKRSDQILNHVIRPVVEERGYVAVRGDEIERSGMITSQVLDRIILNDLVIADLTDQNPNVFYELAVRHALRKPFVQLLAKDQQLPFDVHGMRVISVDHTDLDSVHQAKKQLGRAIDAFGEGDDIVTPISIALALQELRGSTSPREAGLSQIVETLPQMMDILQDVQRHLGTGGFSEGPADDDNRRLRTLVDSLATRGAVTADELSGLLGGGNGRFERWVEALIQRVGRTTNHRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3X5</accession>
    <name>F4F3X5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27741"/>
    <dbReference type="EnsemblBacteria" id="AEB46621">
        <property type="protein sequence ID" value="AEB46621"/>
        <property type="gene ID" value="VAB18032_27741"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27741"/>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055269_1_0_11"/>
    <dbReference type="OMA" id="YQHVHPE"/>
    <dbReference type="OrthoDB" id="1271038at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="32021" checksum="CB8BC9BE7BE70900" modified="2011-06-28" version="1">MTTTDQRPATLAEIVDGASQPGRPGPDGAPAGRVGRYAAAVLVLGLTLAVGFFAGRAGGTTAPARPAAAGALAHANHGPGGLEVSRDGWTLTVDQARLRAGKPGELVFRITDTAGAALTDFQVVHDRPLHLILVGRDLGGYQHVHPEMSPDGSWRVTITPAAPGPLRAIADFWPTGAAAGTTLGIDLPVPGRYAAEELAPPEETVLVDGYTVTLDGGLRAGESNQVLVWLGRDGQPVNDLQLHLGAYGHLVALRQGDLAYLHVHPAAASQPSSVVAFGVTVPSAGTYRLFFEFRHLDEVRVAAFTVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3X9</accession>
    <name>F4F3X9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">gltX</name>
        <name evidence="13" type="ordered locus">VAB18032_27761</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27761"/>
    <dbReference type="EnsemblBacteria" id="AEB46625">
        <property type="protein sequence ID" value="AEB46625"/>
        <property type="gene ID" value="VAB18032_27761"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27761"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_11"/>
    <dbReference type="OMA" id="NFACACD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
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        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
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        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
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        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="5"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="316"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="234"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB46625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="471" mass="52256" checksum="D84456145EF1765C" modified="2011-06-28" version="1">MVVTVRVRFAPSPTGMFHVGGARSALQNWIYAKQQGGVFVLRIEDTDAARNSPEWTEGILSALDWIGISRDSYEGPYFQSSYAQEHRAAAARLHDSGRAYYCDCTREAVQARTGNQYTGYDGYCRDRGLPPGEGRALRFRTPDEGTTVVTDLIRGEPTFENKLIEDFVIARGDGSPVFLLANVVDDMTMGITHVIRAEEHLPNTPKQQLLWDALGVKPPVWAHVPVVVNEKRQKLSKRRDKVALEAYRDEGYLAAAMRNYLMLLGWAPSGDREIVPWSVIEDEFRLSEVNPSPAFFDEKKLRAFNGEYIRALPVEEFIEACRPWLTGTGTIAPPPWQPEEFDPAVFATVAPLAQTRIAVLSEIVPNVDFLFVATPLIDEAAWTKAMKEGSAELLEATIAAFEAVDSWDAQTLKATLEAVGAERGLKLGKAQAPVRVAVTGRTVGLPLFESLEVLGPERTLTRLRAARLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F495</accession>
    <name>F4F495_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04130"/>
    <dbReference type="EnsemblBacteria" id="AEB47908">
        <property type="protein sequence ID" value="AEB47908"/>
        <property type="gene ID" value="VAB18032_04130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04130"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_1_2_11"/>
    <dbReference type="OMA" id="YIWRTSY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="27"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="387" mass="40953" checksum="14C8779BBC233F62" modified="2011-06-28" version="1">MLAALGAGGLAAGCASDTEEPAKPKSPVKVGLVAPQSGSGKAVGDELRNGFQLYLDLNEGQLGGHPVNLLVADEGDSVKSGQAAVDGLLKQGVLALTGVASSAVMFGIRDTIEQARVPLIGSNASPSSLQSVVYIWRTSYVLDEAGRALGRYLRDVLGPDDRVAIVMPESAVGGDDVLLGFRQEFGESDPRIADQVVFTTNNANPGKGAFVRDIDRALSRNPSVVFCFYSGPAAAEFIMQLRDAGFQGGIYAPGFLTEGTVLDSVRPANDALGIRTALNYSADLNNAANRRFASAYRKKHSASPTTYAMASYDAAKVLDQAIRLAGEDPTPQTVNLALGRIGQIDSPRGAWQFNQPRTPQQKWYLREVQHDGQVLSNVMVSELATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F497</accession>
    <name>F4F497_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, asnc family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_04140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736542.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04140"/>
    <dbReference type="EnsemblBacteria" id="AEB47910">
        <property type="protein sequence ID" value="AEB47910"/>
        <property type="gene ID" value="VAB18032_04140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04140"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="OMA" id="GPSKLHM"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="16104" checksum="8F113293A3E85F1A" modified="2011-06-28" version="1">MQIDAVDQRIIALLVADARASYADIGTRVSLSAPAVKRRVDRLRAAGVIRGFTAIVDPASVGWTTEAFVELFCAGRTTPAQIGAAVRRHPEVVGAYTVSGEADALVHLRAADIAHLEQALERLRAESFVTSSRSTIVLSRLVESPGVGPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4V1</accession>
    <name>F4F4V1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734093.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21700"/>
    <dbReference type="EnsemblBacteria" id="AEB45440">
        <property type="protein sequence ID" value="AEB45440"/>
        <property type="gene ID" value="VAB18032_21700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21700"/>
    <dbReference type="eggNOG" id="ENOG502ZKTM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047832_0_0_11"/>
    <dbReference type="OMA" id="NDSEQWH"/>
    <dbReference type="OrthoDB" id="1661570at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="444" mass="46712" checksum="A0DF8BD56E66E0C9" modified="2011-06-28" version="1">MNILGLELRRSAAPGAALITVMIGAGALYAATGRWSSGWMALAMTMREYLLLLWPLALAAGAWQGRREHRARVGELFASTARPRAQRMLPILGAMAVALGLAYLLVTAAGIAWIITTAQHRPLLNFIVVTAVGALSLVAAAWLGLGIGRMLPALATAPALGVAGVLLIFFSVVRFPDWLAAAVSPAHGSSPFHAYQTIDNRVSGTLAISMTALALTGLLLFGAGGWRGRTAALLPAVLGITAAIAVVPRDQDVLNWPVDPVARQLVCTDDTPTVCVSRVHANVLDTLTPLAREGLTMLAKLPDAPTAVHEDTFSHVLGDVRSTQDGVVTIEIGIDGRGGLAHPAAVVPGILRRLGVEYDGNCRQGDEAVERAAAYWLMGRKPRSDVGLVPGMIFEEPEINAEAVTLWQGLRELPDAEALARITAVRDALRACTDVSGLLSGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Y1</accession>
    <name>F4F4Y1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21850"/>
    <dbReference type="EnsemblBacteria" id="AEB45470">
        <property type="protein sequence ID" value="AEB45470"/>
        <property type="gene ID" value="VAB18032_21850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21850"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4978">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065103_2_2_11"/>
    <dbReference type="OMA" id="HYDKEEI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="30011" checksum="A1C931D056BBF8DA" modified="2011-06-28" version="1">MTLRKGLTIGEFATVTRLSVRTLRRYHESGLLVPATVDPHTNYRYYLPDQIATAQVIHRLRELDVPLAEVRSIITTGDPHQRAELIAGHLRRLEAELDRTRAAVVSLRQLLQPDAATLDVELRSVPARTVVAISATVRIEDSLAWFDTAMDELDAAFPPAERAGPSGGRYANELFTDGVGVMTVFRPVRSPHDGGRMEVVEFPATDLAVAVHAGPHDDIDVTYGRLGDWVVSHALGIDGPVHETYLAGPRDTGDARRWRTEIGWPVFRLTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F595</accession>
    <name>F4F595_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ordered locus">VAB18032_04305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007073789.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="SMR" id="F4F595"/>
    <dbReference type="STRING" id="263358.VAB18032_04305"/>
    <dbReference type="EnsemblBacteria" id="AEB47943">
        <property type="protein sequence ID" value="AEB47943"/>
        <property type="gene ID" value="VAB18032_04305"/>
    </dbReference>
    <dbReference type="GeneID" id="5704586"/>
    <dbReference type="GeneID" id="67458323"/>
    <dbReference type="KEGG" id="vma:VAB18032_04305"/>
    <dbReference type="PATRIC" id="fig|391037.6.peg.5115"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_1_0_11"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="8944" checksum="DB4BD2FCF010AC48" modified="2011-06-28" version="1">MAKAAALRKPKKKVNPLDKDGITYIDYKDTALLRKFISDRGKIRARRVTGVTSQQQRQIARAVKNAREMALLPYTATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5A2</accession>
    <name>F4F5A2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736581.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04340"/>
    <dbReference type="EnsemblBacteria" id="AEB47950">
        <property type="protein sequence ID" value="AEB47950"/>
        <property type="gene ID" value="VAB18032_04340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04340"/>
    <dbReference type="eggNOG" id="ENOG5032SMG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124443_1_0_11"/>
    <dbReference type="OMA" id="PTDERCP"/>
    <dbReference type="OrthoDB" id="2016256at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035169">
        <property type="entry name" value="DUF5318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17249">
        <property type="entry name" value="DUF5318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="17022" checksum="73CF04293B8A6938" modified="2011-06-28" version="1">MRTQRQVVDYSLRRRALLRELVAGRVGTYDLCDASPYLKNAARFHGEPTDQRCPICRSENLTHVHYIYGDELKQSAGQARTVAELSMLAMTLREFQVFVVEVCLGCDWNHLVEQYLLGRDGLTESEAEHEAAGGVAAAAAGANAQRRREAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5C0</accession>
    <name>F4F5C0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04430"/>
    <dbReference type="EnsemblBacteria" id="AEB47968">
        <property type="protein sequence ID" value="AEB47968"/>
        <property type="gene ID" value="VAB18032_04430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04430"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_11"/>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="34854" checksum="882E11E81B5C4ACC" modified="2011-06-28" version="1">MIPTGPAPDAGAGSAAIPTAPSVAPAVDAPPTVSVPAPAITPDPILSPVPGARFAEIPVDSIVPNPKQPRQVFDEEALEELKTSIREVGFLQPIVVRQLDDEKFELVMGERRWRAAQAVERETIPAIVRDTRDDAMLRDALLENIHRANLNPLEEAAAYQQLLEEFGATHEELARRIGRSRPQISNTIRLLNLPAQVQRRVAAGVLSAGHARALLSLEDPQAQEQLALRIVAEGLSVRATEEIVALSLSEGAGKKETAKRRAKPHAPGLNDLADRLSDRFDTRVKVDIGRSKGKITIEFATVDDLERIVDLIGVNREQTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5J0</accession>
    <name>F4F5J0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731693.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09520"/>
    <dbReference type="EnsemblBacteria" id="AEB43022">
        <property type="protein sequence ID" value="AEB43022"/>
        <property type="gene ID" value="VAB18032_09520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09520"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_1_11"/>
    <dbReference type="OMA" id="ISAMETC"/>
    <dbReference type="OrthoDB" id="1478362at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="72"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="28395" checksum="E3D0C6D97CA7DAE7" modified="2011-06-28" version="1">MNEVLRLAMANKGETAESLAGKVGVDPKTAGRWIADGRVPHPRTRVAVATVLGRQAEELWPEPFRRRDLPWFREWADLEQKASSLRSYEPLLVPGLLQTEAYARGVLATGGLLSPTEVEEIVAGRMARQRVLERESPLQLVAVIDEVVLRRQVGGDRAVMVGQLGHLAELSEREHVQVRVIPAENPWHTGLAGPFVLARTPDSGEAAYLDNQLRGQVVTERADLASLSARWESVTGEALPRRQSIELIREVATTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5M3</accession>
    <name>F4F5M3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15620"/>
    <dbReference type="EnsemblBacteria" id="AEB44236">
        <property type="protein sequence ID" value="AEB44236"/>
        <property type="gene ID" value="VAB18032_15620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15620"/>
    <dbReference type="HOGENOM" id="CLU_2848626_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="6927" checksum="5DB8E092349CBC62" modified="2011-06-28" version="1">MGSQRPSRARGAGTGNRSGLADSYRLALRAMALANARLDDLTDARTLLADHPPLSAVVDTDLHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5S7</accession>
    <name>F4F5S7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type iv secretory pathway virb4 protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15900"/>
    <dbReference type="EnsemblBacteria" id="AEB44290">
        <property type="protein sequence ID" value="AEB44290"/>
        <property type="gene ID" value="VAB18032_15900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15900"/>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009097_4_1_11"/>
    <dbReference type="OMA" id="GENHLPF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="230"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="2">
        <location>
            <begin position="440"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="567" mass="59622" checksum="611841154B17BCC5" modified="2011-06-28" version="1">MPSPAALEVTASHLRVGDGYAATYVVCGYPAEVGPAWLDPLLSYPGRVDVAVHLEPVAPQVAAPMLKRQRARLESSRRLDAEQGRLDDPMVEAAAADAADLAERVARGAAKLFDVGIYITIHARTLEELTTVAAGVKSAAASVLLDLQPATFRQQQGWTSTLPVGVDPLRMRRILDTTALAAAFPLASADLAAPSPGVVAAPQGVLYGVNTTSHGVLVWNRWAQDNHNSVVLARSGAGKSYFVKLDVLRNLYQGTAVSVIDPEDEYAPLAAHVGGTVVQLGQPGVRVNPLDLPADQRPDTLTRRGLYLHTLIAVMLGAAPSPAERAALDRAITATYAGAGITGDPATWTKPAPLLRDLAATLAADDAPAAGQLAARLAPWTSGNFAGLFDGPTTTAPTGHLVVWSLRHLPEELRTVGTLLALDSIWSGIDNPPSGGRRRRQLVVVDEAWLLMRDGEGARFLFRMAKAARKRSAGLCVITQDAADVLATDLGLAVVSNAATQVLMRQSAQSIDAVAEAFHLTAGESRLLLSAPRGEGLLVAGRSRIPFRSVGSAAEHRLAVTGVGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6G7</accession>
    <name>F4F6G7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M6 immune inhibitor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09975"/>
    <dbReference type="EnsemblBacteria" id="AEB43113">
        <property type="protein sequence ID" value="AEB43113"/>
        <property type="gene ID" value="VAB18032_09975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09975"/>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395692_0_0_11"/>
    <dbReference type="OMA" id="FAHEWQH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M6" evidence="1">
        <location>
            <begin position="479"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="703" mass="76026" checksum="CBA44D80502FA04E" modified="2011-06-28" version="1">MAPSAADTGGLATDIRELTRKDFTFNGKKVEVPTQYQPKAQSRRTQAAAETPPVGTVRNWLALDDYQGVIYLKPYTLRGVGDNIEVWVANDTEFPEGDCRQQIPNSTVITDAQVNRLISEFDTNMYPKSIAAFSTPPERDGTNAELAGDFTGAGNRTVTLVDNVRDDNFYDFPAAASYIAGFHFSLFDELLDRNIMTVDAFDWAHRTGENPPNEPTDDVCTSRPARPNLYEGVFVHEWQHLAHYHADPFESVWLNEGLADFAQTLAGYVDARARIDQPGTDSHIYCFQGFGTVQTPYNTNPRDCGGPENSINLWNEGSTSSAVLADYGNAYSLMLFLYDRYGLDFISRLHQDGDLQGLASLKAALADEGVKDMYKVLHDYQTMNLVDRIVGNSKLGIMLGVDKRRVTTDSLNATVNLDNPASYATPGAAPNGADYVQLRKANGKPLGRGDLRSIKFQGAKSLPAIPLAWTTVSNDPDRPGNSVIWSGNGNSTDAAAVTPVTVPAANPTLTFLAKYGAEVGYDYGYVSVSADGGKSYTPIAGDKTVSGPLGPALNGTTSGFEPHSFDLSAYAGQQILLSFRYVSDGGVNEGGLLIDDITVGGTLVSDGSSLAPFDSPSEIYPTPVANWNVRFVGLDEKNKIAYQYEVNGKSSFTLGTLPTLALLTFPKVVAIVAYDEPTEQVTQYAPYKLTVNNVVQPGGGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6X7</accession>
    <name>F4F6X7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734304.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22760"/>
    <dbReference type="EnsemblBacteria" id="AEB45652">
        <property type="protein sequence ID" value="AEB45652"/>
        <property type="gene ID" value="VAB18032_22760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22760"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_2_0_11"/>
    <dbReference type="OMA" id="LPMCGTS"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043839">
        <property type="entry name" value="PafC_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19187">
        <property type="entry name" value="HTH_PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_PafC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="147"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="334" mass="36554" checksum="54FDCC26C700EEFF" modified="2011-06-28" version="1">MSAKAGTRTSADRLARLLNLVPYLLARPGIEIAEAAGDLGVTERQLREDLELLWVCGLPGYGPGDLIDMAFDGDRVTITYDAGIDRPLRLTPDEALALVVALRMLAETPGVANREAVERALAKIEDAGGDLVAAPVEVRLPGDARRVEQLRAAVEGGRALRITYYTRARDETTERVIDPLRMLMAGGRAYVEAWCRRAEAVRLFRADRIDAVTELNEPAVVPPQARPQDLSEGVFRPSPDLPLITLRIGRGERWITEYYPCERVESDGERWVVSLRVTDLGWARRFVLGLGSEVTVLAPAELAEQVRDTAVAALEAYATPVLPGADPAATVPWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Y4</accession>
    <name>F4F6Y4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_22795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734311.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22795"/>
    <dbReference type="EnsemblBacteria" id="AEB45659">
        <property type="protein sequence ID" value="AEB45659"/>
        <property type="gene ID" value="VAB18032_22795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22795"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_11"/>
    <dbReference type="OMA" id="FFTEDTP"/>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="333" mass="36148" checksum="84AD05B590155BAA" modified="2011-06-28" version="1">MRILVTGGAGFIGSEYVRMLLGAPGGSAEGVPPIQPSQVTVLDALTYSGNRANLAPVADDPRLRFVHGDIRHAEVVDEVVAGQDVIVHFAAESHVDRSISGAGPFVCTNVLGTQTLLDAALRHGVRRFVHVSTDEVYGSIAEGSWTEDWPLAPNSPYSASKAGSDLLALAYHRTHGLDVVVTRCSNNYGPYQYPEKVIPLFVTNLLDGRTVPLYGDGGNVRDWLHVHDHCRGVAMVQQGGRAGEVYHIGGGTELTNKELTGRLLQACGADWDRVTLVADRKGHDRRYSLDINKINKELGYAPTVGLDDGLADTVDWYRDNRSWWEPLRKASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Y8</accession>
    <name>F4F6Y8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="7" type="ordered locus">VAB18032_28906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735501.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28906"/>
    <dbReference type="EnsemblBacteria" id="AEB46852">
        <property type="protein sequence ID" value="AEB46852"/>
        <property type="gene ID" value="VAB18032_28906"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28906"/>
    <dbReference type="eggNOG" id="COG1492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019250_2_2_11"/>
    <dbReference type="OMA" id="EIHHGVA"/>
    <dbReference type="OrthoDB" id="744477at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="261"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="512" mass="53910" checksum="8257887156AFFC27" modified="2011-06-28" version="1">MSGGLLVAGTTSDAGKSVLTAGICRWLHREGVKVAPFKAQNMSNNSAVVVGPDGRGGEIGRAQAMQAAACGIAPDLRFNPVLLKPGSDLSSQVVLLGEAVDTLTADTFTSLRPRLAETAYAALSELRSAYDVVVCEGAGSPAEINLRDGDYVNMGLARQAGLPTIVVGDIDRGGVFAAMFGTLALLDPADQALIAGFVVNKFRGDRGLLEPGLAMLSQVTGRPTYGVLPWAVDLWLDAEDSLAYGRVLGRPAAPHGTEWLDVAVVRLPRVSNATDVEALATEPGVRVRLTVEPAELAAADLVVLPGSKSTVADLAWLRETGLADVITAHVAAGRPLLGICGGFQMLARAIHDPVESRRGSVSGLGLLPIEITFDPRKTVRAATGTFSDDLPVGGYEIHHGYVSAADPTLTPLLRYLDGGGEGAVHGVVHGTHWHGAFESDEFRRWFLTRVSRLAGRTGFRVAQDTSFAAARNRTLDLLGDLVEEHLDTAALRRLIESGPPIDLPFVPPGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F753</accession>
    <name>F4F753_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29231"/>
    <dbReference type="EnsemblBacteria" id="AEB46917">
        <property type="protein sequence ID" value="AEB46917"/>
        <property type="gene ID" value="VAB18032_29231"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29231"/>
    <dbReference type="eggNOG" id="ENOG5033D4C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184565_0_0_11"/>
    <dbReference type="OMA" id="RDEICRQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="90" mass="9936" checksum="A33B91CD0F04E0F7" modified="2011-06-28" version="1">MTVHDPGAGPPDEYVEAEIHRLLTEDPAVAEQGITVVRTERGLVLYGEVESAYRRNEILRRVAGRFPDVPITSDIGVTRAQAPTEIEQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7B3</accession>
    <name>F4F7B3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731842.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10265"/>
    <dbReference type="EnsemblBacteria" id="AEB43171">
        <property type="protein sequence ID" value="AEB43171"/>
        <property type="gene ID" value="VAB18032_10265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10265"/>
    <dbReference type="eggNOG" id="ENOG502ZA0J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027239_3_0_11"/>
    <dbReference type="OMA" id="WMQMICA"/>
    <dbReference type="OrthoDB" id="1555988at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="33339" checksum="6889881B0F1EB854" modified="2011-06-28" version="1">MPDPLTRYRCADEDSIRWRDFPLRPGDIVISTRSKSGTTWMQMICALLVLRTPDLPAPLTTLSPWLDWLVEPADQVYARLAAQRHRRFIKTHTPLDGVPADPLVHYLVVARHPLDMAVSLHHQSGNLDRARLAELTGHPGSPDPDRRRPSVEEALVRWIDADPDPREELDSLPGVLWHLRDAWARRDQRNVHLIHYDDLRADLAGQMRRLAEMLDLEPPGPELVEAATFDRMRSRADRLAPDPAGVLKDRQAFFRTGRSGQGSALLSAADRARYHARAAALAPPDLLTWLHRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7V8</accession>
    <name>F4F7V8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735581.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29311"/>
    <dbReference type="EnsemblBacteria" id="AEB46933">
        <property type="protein sequence ID" value="AEB46933"/>
        <property type="gene ID" value="VAB18032_29311"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29311"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043255_0_0_11"/>
    <dbReference type="OMA" id="AAPHEIF"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="375" mass="40835" checksum="18657A274C69701B" modified="2011-06-28" version="1">MSEPVEQARTVLTTAPADLLLSRIRALLDQEYGIADVELLQVDYRLAALLPLTPGEAVSEPGHPAWRCFDHQSPVYVDSTAYLPVSMRGERRGVLRVHPVTDEGLLADLAEIGTALAHELTAVDPGTDVYRTARRARRLTLAAEMQWELLPGRSRIRPSFSLAGQLEPAYAVRGDSFDWSDDGDRVWTATINGMGAGVAASMLTTLATSALRNARRAGISLADQAALADQAIYALHRGEQHLATLLVEVDLHSGLLTAVDAGSPRLVLLRDGEVSVQPLEAQFPLGMFEGSHYREQHIQLRPADRLFMISDGVLDATGQEVRYGESALDRMLRRTAPMSPLDAVRSLLGDLRAFVAGDLTDDAVVVCLDWYGPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Z7</accession>
    <name>F4F7Z7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29506"/>
    <dbReference type="EnsemblBacteria" id="AEB46972">
        <property type="protein sequence ID" value="AEB46972"/>
        <property type="gene ID" value="VAB18032_29506"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29506"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_4_1_11"/>
    <dbReference type="OMA" id="HINQPTH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307490" evidence="2">
        <location>
            <begin position="26"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="87"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="31499" checksum="2DF166D588FC8CB9" modified="2011-06-28" version="1">MATLAAVAGALTLLAVLNPLRQPDGADLGPQSSGARFVETEVGAGDRPEVSATPSSMSPTPPAGTLPGATRTDALPPVVDHGPRRGNKVALTFDADMTDAMRRQMRGGAGTSYANLKIIDRLERDGVPATFFLTGMWVEQYPDVTRRLAANPRFELANHTYGHHAFTADCYGLPRIAPRKMTADVARTFDLVSAYGGRQTRYFRFPGLCHDRAALTALAPLGLTVVDGDVVSGDPFATAWQPIVRAVLDQVRPGSVIVLHVTEANAPMTDEALPHILAGLAERGLEPALLSEVLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F800</accession>
    <name>F4F800_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_29521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735623.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29521"/>
    <dbReference type="EnsemblBacteria" id="AEB46975">
        <property type="protein sequence ID" value="AEB46975"/>
        <property type="gene ID" value="VAB18032_29521"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29521"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_4_0_11"/>
    <dbReference type="OMA" id="WFEPLVN"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="33"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="30592" checksum="FECEBB7B2BB59955" modified="2011-06-28" version="1">MTTTTKPAAPVAAAAPARRPGPASLALRQGRMEIRQFLRSRESVVFTLGFPIIMVLIFASIFDGDLGNGVSYTQYFITGMIATGLMTVSFQNLGIWIPIERDRGVLKRYRGTPMPKWVWFAGKVIMVLVTGVVMTALLLGVSVALFDLDLPSTASAWLTFGWVSALGITACTLCGIAISSLARTARSGSAVVTPIALVLQFISGVFFVFTNLPTWMQQVAAIFPLKWMCQGLRAVFLPESFGANEPGGSFELTRVALVLGLWCVIGLVLCLTTFRWTTRRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F810</accession>
    <name>F4F810_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpC</name>
        <name evidence="10" type="ordered locus">VAB18032_29571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735633.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29571"/>
    <dbReference type="EnsemblBacteria" id="AEB46985">
        <property type="protein sequence ID" value="AEB46985"/>
        <property type="gene ID" value="VAB18032_29571"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29571"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_4_0_11"/>
    <dbReference type="OMA" id="AADHFVW"/>
    <dbReference type="OrthoDB" id="1696893at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="94" mass="9559" checksum="817FDDBEE220419A" modified="2011-06-28" version="1">MAEQLNVQLVAVEEKVWSGKAEMVMARTTEGELGVLPGHAPLLGQLAEPGQVRIKLPGGEQVAYEVSGGFLSVSGQGVTVLAESATPASAASGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F820</accession>
    <name>F4F820_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735643.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29621"/>
    <dbReference type="EnsemblBacteria" id="AEB46995">
        <property type="protein sequence ID" value="AEB46995"/>
        <property type="gene ID" value="VAB18032_29621"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29621"/>
    <dbReference type="eggNOG" id="ENOG5033I3C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1634210_0_0_11"/>
    <dbReference type="OMA" id="KILYVEP"/>
    <dbReference type="OrthoDB" id="1986294at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="15850" checksum="9A3B251E55204F75" modified="2011-06-28" version="1">MTAPRAGEPGLSTTAPRAGEPGAIRARLPHLRLPLLACAALAVVAVPVAAWLRGPTSAAGVAAGIALVIVSYLISSFSVAWADAVHPKLIMSVGLITYATKIVILGVAMAAVAATGWPGLPDMGVAIIAAVVVWTGAHLTWALRTPLPTVDRSVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F824</accession>
    <name>F4F824_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low molecular weight phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735647.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29641"/>
    <dbReference type="EnsemblBacteria" id="AEB46999">
        <property type="protein sequence ID" value="AEB46999"/>
        <property type="gene ID" value="VAB18032_29641"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29641"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_1_0_11"/>
    <dbReference type="OMA" id="LDDPWGR"/>
    <dbReference type="OrthoDB" id="2062716at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="21581" checksum="9B1D6472C1835870" modified="2011-06-28" version="1">MPPFTVLHVCMGNICRSPMAERLLVVAVRERLVRRDVDPARADEVLHSHSAGTGGWHAGEEMNPPAARQVVNRGGSTAGFAARKLRSDHIDAADLVLTATADQQEYVVALRPDAASRTFVLGEFGRMLATLDPATLPAAEATPEAVHARGVALVEAAHAARQGSALLPGDDLDDPWGRGDQCFTRVADEIEETVQPLAAALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F876</accession>
    <name>F4F876_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731908.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10595"/>
    <dbReference type="EnsemblBacteria" id="AEB43237">
        <property type="protein sequence ID" value="AEB43237"/>
        <property type="gene ID" value="VAB18032_10595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10595"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="KQIAEPC"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="35517" checksum="6C207A1B8D4EE7CE" modified="2011-06-28" version="1">MSLLEIDDLRVAFPSPNGPVNAVNGVSLEVDSGRTLAILGESGSGKSVTAQAVMGILDVPPATVSGSVRLQGRELLNLPRKQRERISGEEIGMVFQDAMAALNPVFTIGHQIMEVLRVRRGMSRADARRRAIELVDRVRIPAARDRLRDYPHQFSGGMRQRIMIALAISLEPDLLIADEPTTALDVTVQAQVMELLAEIQRDSGMGLLLITHDLGVVAEVADEVAVMYAGRIVERGTVEQIFAGPAHPYTEGLLASMPRVDRRDEQLYAIPGAPPNPARLPTGCPFHLRCPRATDECLVTLPPLHALPADRASACHHHEEVLGATQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8H5</accession>
    <name>F4F8H5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diaminobutyrate-pyruvate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733175.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17080"/>
    <dbReference type="EnsemblBacteria" id="AEB44520">
        <property type="protein sequence ID" value="AEB44520"/>
        <property type="gene ID" value="VAB18032_17080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17080"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="OMA" id="HAQFSRH"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="519" mass="54926" checksum="E592AB0E736413A9" modified="2011-06-28" version="1">MTTEFPELAEAHLGGLLDQLGLAVPYSRASGDTLYFVDDTGAEVAVDDFVGGYGSLIFGHHHPTLTRLLHDLLERQVPVHAQFSRHPYANDLAAALNRVLHREFGIAEPYRAIFANTGAEAAECALKHAEMERGQRVAALIAEIDTHLDDARAAAAAGAGLPGDAATARLGAFTGVDGLIAAVRQHNTAQLARGPVFLTLENSFHGKLAASVQLTHNPAYRLPFRTLAAPARFVPVDRPGAVAKAVEAERVTVFDLESGDGAVRLVERDLPVIAAFFAEPVQGEGGIRPLDAALAAEIRQAAEAGGFPVVVDEIQTGVGRTGTFFAGAQAGLLGDYVLLAKSIGGGLVKNAVLLVRDSRYQPEFELVHSSTFAKDALSCHIGLAVVDLLEADGGQAYRTVRERGDALRAALDGAAEANADVVAEVRGRGLMQGLEFRDQTDAPAGVVRDFARNGLFGYMVAGRLLRAHRIRVFPTASAPHTLRFQPSLAVTDEAIARLVTGLTDVCALIRANDPTLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8K5</accession>
    <name>F4F8K5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VTC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
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            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
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            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="277"/>
        </location>
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        <location>
            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="34744" checksum="AFA259835528B226" modified="2011-06-28" version="1">MRSWLRRAASQAPDPQSSSRPQSTPQVGPETGDDRGGHALRAPSRLHAFNRYEIKYLVPTGDVPALREHFAARMDRDSHGGDTGYGVWSVYYDTAELRFYWEKIEGLKFRRKLRVRHYGEASTVTDDSIVHVEIKQRVNRVTQKRRVALPYHLARDLCDRRQLVEHTPEQRAFLDEVLELLCGLDLRPVAMTGYQREAFIGRDADLGLRVTLDHRVRGRDRDFHLGADAENRLIVPATFSVLEIKANERVPYWLTDLAARTNLSIVRMSKYCQSVEAFGRAPRSLFHVPDDADPAAAGSPLKSEV</sequence>
</entry>
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    <accession>F4F8W8</accession>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
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                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
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            <dbReference type="PubMed" id="21551311"/>
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            <strain evidence="2 3">AB-18-032</strain>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1184" mass="116982" checksum="0F0C5769944C7570" modified="2011-06-28" version="1">MRLAARVKDDCVTGYPCPACGAPANLASGCSGCGRPPYPAAAEVIRLDREIVELGAATRQARATYEGLAGRLLTAQRRRAELAAAIRTEFPTPTPAGSLAGAVPPAAKPVAVPAGPGGALPAGPGGMPPVGPGGAGSGGWPGMTPVDPAARPGGAEASTRTVQGLLFVLGGLLLGTAATVFTAVAWASVGVTGRALILLALTLLLLAVPLVARWRGLRGTAETFAAVGLLLVVLDGYAAWSVDLFGVTAWPGSLYAAVVAAVSAALAAGYARLSRLTVPWFAALLAGQPVLPLAVAEARLGPGGLAVVFVGVALADLAVLVALRRPRDVAGEGATTTSAVRIAGQVTAGAGYAVALLLAAGCALVPLLVGRAGGMAVLAGVPMLLVALALLGAALLLGGAVARAVTAGALVPVLALALIRPVGELRGSVVLVAAALVVALLAGAVRLLPAGWQPGPRIGAVLVAAATATLTTLWAVVLAGATVGRSLPPWRGATAGPDYPWGWQLPVALALTVATLAWLLPRVAQPAIAVIGVAATTLALPAAWAAPWPVVVAVDLLVAVALLAVSVARPVGRATVLASALAGAVLLGHGLLVGLAGPAGAGAACTVVLVAGLGVAAVGRRGGPEQRVVAGFALLAAVLVVPAGAAVALIGAGAPPWWQSRAALAALVLPAVALVALRTHWTDLRAYASTGFAVAATLTGLVSVAVPGDEPLTLYAAGTALLVALAGFRSRPAVALSVAGVGLAAVAVLAAVPVALTALVTPYGPPPAIWSGAPAARSVVGAVPVGVALSVLALAAVLATWPTGRAGGRWRLAAAVLPFVALAGPVLLVAARAPWPVVPTAALFGGVALLLVIAVRPVDAPFVAVGVPVGLVLIGAGLLNLQATRAGTLAGLGLLVVAATVAGVAARRHLVRLAGWLVAVAAATGLAITASLAAGQPLRVAAFAVLGVAAVALALAAIVSGISALSGRVLDAAAQAVALVGILLTIGAARHAATVCVLWAVAVGLRLLRRGESTARRWVFAAISAGNVLLAVWLLLGSGGVTVLEAYTVPFAVLALGAGTVVLRTRPGLTSWLALGPGLAAVLLPSLAAVLFGADPQPWRRLLLGAAALAVTLLGAIRRWQAPVVLGGSTLAVLAVHELVRSWDLLPRWAYLGTAGLALIALATTYERRRRDLLRLRATVSRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F906</accession>
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        <submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
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            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
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            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50968"/>
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    </evidence>
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            <dbReference type="EMBL" id="AEB47086.1"/>
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    </evidence>
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        <source>
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    <sequence length="71" mass="7426" checksum="939FC0B4498D12AA" modified="2011-06-28" version="1">MAEEIRAEMVANVWKVVAAAGDTVSEGDTLVILESMKMEIPVVAESDGVVQQLAVNEGDVVQDGDLIAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F923</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
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                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
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            <dbReference type="PubMed" id="21551311"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="KAWMEAN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="219" mass="23744" checksum="183395100ACAA1F4" modified="2011-06-28" version="1">MSGGDRLPMVFLTLLPLAVVMVAGTQLVAAVFFASSDRPRAASLGYLAGAAIVVGGGTTVAWLALRLFRIRFSTGSERGAVERNIDWLVLGVLVVLAIVVYLLRHHGPPSWMGRLQHASPGYAFRVGLLLFLANPTDGLTMIAVGAAAARRDEAWWHLLPFVLLTLTLLALPLLALLLLGHRAEVVLPRIRRWADTHSWIVSEAVIAIFFAITVVDLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9I6</accession>
    <name>F4F9I6_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17310"/>
    <dbReference type="EnsemblBacteria" id="AEB44564">
        <property type="protein sequence ID" value="AEB44564"/>
        <property type="gene ID" value="VAB18032_17310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17310"/>
    <dbReference type="eggNOG" id="ENOG5031SFD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084790_0_0_11"/>
    <dbReference type="OMA" id="PQWWAPV"/>
    <dbReference type="OrthoDB" id="2092326at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="286" mass="30148" checksum="2BB231B49D76D32C" modified="2011-06-28" version="1">MLLRAYPAGYRRERADELIDTLIGDEPTTRRWPSIRQAASLIRGGLRVHGGSTAARPTAVLLWQGLHLGAMAVLALGVLIGLNDIVGTFQFGGISDPLHVLRNEGIQTVMAIAALVALVAGHDRTAAVLVVTAVVVPTVISPYLFLNGLPQWWAPVVAAPLVIAGLRRPADVPPAPRANALLVTAGILALHLIPVEGYRPAPVGTQIITVAMVIVGVAVFLWVATADQRLLIAVAPTLLLGTLHQLGYTGTGELLSRPDALPSLALAVVMVVVAVVSTRLRQRTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9M2</accession>
    <name>F4F9M2_MICM1</name>
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        <recommendedName>
            <fullName evidence="1">N6_Mtase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17490"/>
    <dbReference type="REBASE" id="34491">
        <property type="entry name" value="M.VmaORF17490P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44600">
        <property type="protein sequence ID" value="AEB44600"/>
        <property type="gene ID" value="VAB18032_17490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17490"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022127_0_0_11"/>
    <dbReference type="OMA" id="CVRDEGA"/>
    <dbReference type="OrthoDB" id="791672at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="143"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="683" mass="73916" checksum="43CF1C90E04BAB4E" modified="2011-06-28" version="1">MGRAAVSNWRRRYADFPTPVGGTPASPSFDAQEVEHWLHRHGRLHQTSIEQQAWRHIESYQPAAHISDVLGIVGAHLLARAARPDDSGDSPPTPRQLVARLRALDATLATMVSDALPRQWTAQLTALLRSADQLSSARGAESAFEYLHSQYVSSAQSVSGLAGTPESVADVMVAVAGVGTHTFDFTSGTGSILRMAADRALRSGATTRCFAQEINPQYALITSLRLWFVHLRAQQAGHHTPPPVVHVGDSLLADALPDLRADVVVANFPFGIHDWGHDRLAYDPRWTYGLPPRTEPELAWVQHALAHLSPNGTAVVLMPPATASRPAGRRIRAELIRRHALRAIIALPAGLMLPTNIGLHIWVLAQPDPQHPRVGELLFVDATASTGQDLTDTIGTAWAAYQSHHYAQAPGVHRTIAAIDLLDDEVDLTPQRHVPQPTELTAEPARIIANLSDFDHLLEQLRHSLPAVHQTDTAPLRQAPHADIADLIRSGSFSVHRTATRRRAANATVNTRVLTAADIMSGGPATGYTVRATDEPPGPRVRTDDILISVIGHKIIARVATSEQLDAELGPGTQLIRVDTTRFDPWFVAGVISRTDNLRIAGRAASTINGAARIDIKRLTIPVMPLSQQQAYGQAFRKLAEFRTTLDRITGSGAVLAREIVDGLTTGTLGLTPSVTGGDPRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA70</accession>
    <name>F4FA70_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05025"/>
    <dbReference type="EnsemblBacteria" id="AEB42131">
        <property type="protein sequence ID" value="AEB42131"/>
        <property type="gene ID" value="VAB18032_05025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05025"/>
    <dbReference type="eggNOG" id="ENOG5031Y4S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_217443_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="45" mass="5284" checksum="CEFABD55A610CC3D" modified="2011-06-28" version="1">MSMIERIRSRRDANRRARAIERALRSASSPAVRDEILVIAQRHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA75</accession>
    <name>F4FA75_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05050"/>
    <dbReference type="EnsemblBacteria" id="AEB42136">
        <property type="protein sequence ID" value="AEB42136"/>
        <property type="gene ID" value="VAB18032_05050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05050"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093776_0_1_11"/>
    <dbReference type="OMA" id="QWKISIH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="108"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="21646" checksum="FE31C79F0AD286EB" modified="2011-06-28" version="1">MVDRDLVADDVAAARPGPGLRLARIVTELTAPAILVSLLTVVIGWHSAQGRLSGVGWGLVAVVFASLLPMAYIVGGVRRGRLTDHHVRVREQRRIPLLFGLGSVAAGLALLAVLGAPRPVLALVAAGLVGLVVAVTVSQWWKMSIHSAVAVGTLAVLLVTFGVWVLVATPLLGLVGWSRVRLGDHTPAQVLAGGVLGGLVAAVVFTVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA78</accession>
    <name>F4FA78_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42139">
        <property type="protein sequence ID" value="AEB42139"/>
        <property type="gene ID" value="VAB18032_05065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05065"/>
    <dbReference type="HOGENOM" id="CLU_3384340_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="33" mass="3527" checksum="DAC39B24606914D2" modified="2011-06-28" version="1">MSALPRDEPTAAGTEVSLDALGKASARTRRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAG7</accession>
    <name>F4FAG7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732065.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43394">
        <property type="protein sequence ID" value="AEB43394"/>
        <property type="gene ID" value="VAB18032_11390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11390"/>
    <dbReference type="eggNOG" id="ENOG5031YF0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173337_1_0_11"/>
    <dbReference type="OMA" id="HAFGERE"/>
    <dbReference type="OrthoDB" id="2031943at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="78" mass="8589" checksum="5EEE98A2AE9DD45D" modified="2011-06-28" version="1">MTRFLVVLTDVRPCEGGARNERLAPERRRQVVGASSREAAERIAGAFMALGMVRAGRQRVKVIAIGRRHAFGERELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAK1</accession>
    <name>F4FAK1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ordered locus">VAB18032_11570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732098.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11570"/>
    <dbReference type="EnsemblBacteria" id="AEB43428">
        <property type="protein sequence ID" value="AEB43428"/>
        <property type="gene ID" value="VAB18032_11570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11570"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_11"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="32"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="468" mass="51042" checksum="897B880596CCC3F7" modified="2011-06-28" version="1">MARVLTPRAEDFPRWYQDLIAKAKLADNGPVRGTMVIRPAGYAIWERMQAEMDDRIKAAGAENAYFPLFIPESYLKREAEHVEGFSPELAVVTHGGGKQLAEPVVVRPTSETVIGEFMAKWIDSYRDLPLLLNQWANVVRWELRPRIFLRTSEFLWQEGHTAHATREDARAYARKILHEAYEDLMVNVLGIPVVVGLKTARERFAGATATYTCEGMMGDGKALQLGTSHELGQNFAKAFDISYSSAEGGREHAWTTSWGTSTRMLGGLIMCHGDDNGLRVPPKLAPVQAYVMVVKDGDGVGEAAAKLRDALRDAGVRVALDDRTDTPFGRRAVDAELRGYPVRVEVGPRDLAAGNAVVVRRTDGSKAPTPIADVVGAVLAALDADQQALHDQALAFRQSRTIDVATLDEAIEAAATGWARVPWSAVGVEGEAKANAQGVTVRCLVRADNSVPDTEDEPNLTAILARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAR3</accession>
    <name>F4FAR3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_17880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733333.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17880"/>
    <dbReference type="EnsemblBacteria" id="AEB44678">
        <property type="protein sequence ID" value="AEB44678"/>
        <property type="gene ID" value="VAB18032_17880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17880"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040078_1_1_11"/>
    <dbReference type="OMA" id="IACSPFA"/>
    <dbReference type="OrthoDB" id="942354at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="166"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="30131" checksum="26DA2F2D90609CA5" modified="2011-06-28" version="1">MALTADPGALDARPHPASLLHWRCTAERHWDNTDSLLYALGVGAGQDDPAAELRFTTENSAGHPQAALPTFAALLAADPPPLGDPANVRHAEQSLLLHRALPVAGVARITAAVTAVHDQGSGALVRVLSRISDGHGRPLATARAGFFVVGAGGFGGDRAPAAAWPTPAAAPDHEIHYPVPRDQALLYRLSGDRNPLHSDPTVAVRAGLPQPLLHGLCTYGYAGRALLHAVAGSDPARLRGLDARFTAPVYPGTTLTVRIWRRRLGVVFQVVDTTGRVVLDRGAAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB18</accession>
    <name>F4FB18_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45981">
        <property type="protein sequence ID" value="AEB45981"/>
        <property type="gene ID" value="VAB18032_24415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24415"/>
    <dbReference type="HOGENOM" id="CLU_1414652_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="19717" checksum="653BC767A210C397" modified="2011-06-28" version="1">MVQPGGGEQAQCLVGVGRARRGGGPAPGESAAEAGADRGGDGVVEELDLALPGDHLAATRPGLRRRRLGSRAGLRGRGLGAQGRQSPHHRGQAGRVGGTGHREERLRDQTGGGHRVTSTVGRGQQLVGLLLVLLFLETVGLLIDVHVRPSSGGCSRHTLARVSPGPTVVRLVTDSTVWAAPGGCDRTAHDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB92</accession>
    <name>F4FB92_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_00765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00765"/>
    <dbReference type="EnsemblBacteria" id="AEB47237">
        <property type="protein sequence ID" value="AEB47237"/>
        <property type="gene ID" value="VAB18032_00765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00765"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189245_0_0_11"/>
    <dbReference type="OMA" id="LMWEARA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="102" mass="11740" checksum="EC6AD7CCE7783B70" modified="2011-06-28" version="1">MADGHADDRGQRLRKDGDVIVRMWEARAEPYGLAELITWVCDTALPEFEHDPLHVSSEVFSSTDHRVVVISKWRSNPRPLPEPPVMLLARPPHSWDFTQVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB93</accession>
    <name>F4FB93_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[Ribosomal protein S18]-alanine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.266</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acetylates the N-terminal alanine of ribosomal protein S18.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]</text>
            <dbReference type="Rhea" id="RHEA:43756"/>
            <dbReference type="Rhea" id="RHEA-COMP:10676"/>
            <dbReference type="Rhea" id="RHEA-COMP:10677"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.266"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. RimI subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.266" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735883.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00770"/>
    <dbReference type="EnsemblBacteria" id="AEB47238">
        <property type="protein sequence ID" value="AEB47238"/>
        <property type="gene ID" value="VAB18032_00770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00770"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_3_11"/>
    <dbReference type="OMA" id="FEPIGFR"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="147" mass="16638" checksum="3FC699BA02E6A0A5" modified="2011-06-28" version="1">MRLDRFRWWHIDEVLTIEADLFGAEQWSAAMFWNELAHGHHYRIATDDDGAVLGYAGLAVAPPDEAWVQNIAVRRDAQRRGIGRLLLEALLAEAARCDLRSVLLEVAADNAPAQRLYAGYGFEPIGVRRGYYQPSNTDALVMRRIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBJ6</accession>
    <name>F4FBJ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732127.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11720"/>
    <dbReference type="EnsemblBacteria" id="AEB43458">
        <property type="protein sequence ID" value="AEB43458"/>
        <property type="gene ID" value="VAB18032_11720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11720"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923704_0_0_11"/>
    <dbReference type="OMA" id="LWLYLFH"/>
    <dbReference type="OrthoDB" id="1454926at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="29951" checksum="6BBF6553FB7D712B" modified="2011-06-28" version="1">MGEAWRRTKRITRAAFRPVRGRDLSLHAAAITFYGAIAVVPVALLAIWLTTLVAGADRVRRLTSYAVEALPDAIGAPHAVAALVEAGVDLTPWLALAAVLPASLYGEGLRRAFVSVAAPRSDEHLIGWRGRLLLLPLLAPAPALLLAVLLALPTTTGLVRRGGWAGALGVVLSFLAVWLVLTPVLLWVFRVVGRASPDWLSALLVGSFTAANLSGFLHGFVLFASLPLDLGVPFGGLDEVGAAVAILLWLYVFHVIVLAGYSATLALSGWRDRRRRTAPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBM5</accession>
    <name>F4FBM5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11865"/>
    <dbReference type="EnsemblBacteria" id="AEB43487">
        <property type="protein sequence ID" value="AEB43487"/>
        <property type="gene ID" value="VAB18032_11865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11865"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_1_11"/>
    <dbReference type="OMA" id="AVFDCLY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="2">
        <location>
            <begin position="65"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="27336" checksum="8CB5E139966E47AF" modified="2011-06-28" version="1">MAEAGETAESLAAQTGVDPKTAARWISPGRIPQPRRRAQVAAILGRDVSALWPDVLKRREPHWLREWVDWEREAVALRWFEHAWIPGLLQTEAYARATLAGEVLAPDDVDGLVASRLDRQSILRRDRPPMLVATVFEGVLHQSAYGNRDLMREQLTHLLACAALPAVQVLVVPKDVGMYPGLGGGFIIAELPGGEYVAHADSQARAEIVTGAEEVATLSRRWERIRGECLSRAQSLDLIRKAAESWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBU4</accession>
    <name>F4FBU4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733399.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18210"/>
    <dbReference type="EnsemblBacteria" id="AEB44744">
        <property type="protein sequence ID" value="AEB44744"/>
        <property type="gene ID" value="VAB18032_18210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18210"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_1_11"/>
    <dbReference type="OMA" id="READHFV"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="334" mass="34801" checksum="6265AECF5CC192DF" modified="2011-06-28" version="1">MSQRVEVAVIGAGAFGLRHVAAYRSLGVPVTALVDPNPGVRRQVAAEHDVTRTFGTVEELLAAGTPQAASVCVPGPAHRDVAVALLAAGVPVLVEKPLAATVADAEAIVAAARTHGVLCQPGHILRHSAPHRALYDAVRAGRLGQVLAISSRRDRPRTLSRLFPDEHPALLTAVHDIDLAIWYAQSPVVEVRAAARTRPGSATPVLVWAELRHANDVVSSIRNSYLLPAHTPNHTSDLVEVYGTDGVAHVDLGHPTLLVQGEQTEAPDWLLSPVDGGGALAAELRHFVGQVTGVESAAVVPLADGLHVVQVATAMADSAAAGGAPRRISPEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCI9</accession>
    <name>F4FCI9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_05950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05950"/>
    <dbReference type="EnsemblBacteria" id="AEB42316">
        <property type="protein sequence ID" value="AEB42316"/>
        <property type="gene ID" value="VAB18032_05950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05950"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_27_1_11"/>
    <dbReference type="OMA" id="YDIELYQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="65"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="250"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="572" mass="61849" checksum="E00FD29239B66F13" modified="2011-06-28" version="1">MTTSAVSSTPLSAPDIDIDPTSPSADAAVSDDSITFEALGLPEPLARALARQGITTPFEIQRATVPDALAGRDVLGRGQTGSGKTLAFGLPLLARIADGDRARPSRPRALILVPTRELAMQVNDALAPLGRTIGVFLKTAVGGVPYDRQIDALRRGVEVMVATPGRLADLIERGICKLDDVEITVLDEADQMADMGFLPEVTDLLAKTPAHAQRLLFSATLDADVDALVQRFMTDPVTHSTAPATAAVSTMDHHLLLIPPSDKFPVTASIAARAGRTIVFARTQLGVDRLVSQLAAVGVRAGGLHGGKTQRMRTRTLAEFREGRTNVLVATDVAARGIHVDGVTLVLHVDPPKDPKDYLHRAGRTARAGETGAVATLVLPKQRRTTLAMLEKAGVQPAETRVRAGDPALTELTGAREPSGVPVRDEPEAPRRSSRPGGPRRFDGPTTERRYRDRPVSDRRYGDQPRDDRRYRDDSRGTGRYGDDSRGTGRYGDESRGAGRYGADSRGERSYGDSSRSEHSYGGHARGERRFGEPVRGERRYGDRPRSDGRGPQDRPREDWRGPSGRSRARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCN0</accession>
    <name>F4FCN0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="6">FDTS</shortName>
            <ecNumber evidence="6">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thymidylate synthase ThyX</fullName>
            <shortName evidence="6">TS</shortName>
            <shortName evidence="6">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">thyX</name>
        <name evidence="7" type="ordered locus">VAB18032_12050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12050"/>
    <dbReference type="EnsemblBacteria" id="AEB43524">
        <property type="protein sequence ID" value="AEB43524"/>
        <property type="gene ID" value="VAB18032_12050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12050"/>
    <dbReference type="eggNOG" id="COG1351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077585_1_0_11"/>
    <dbReference type="OMA" id="AKLGPRC"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="250" mass="28209" checksum="983800B96F42C80D" modified="2011-06-28" version="1">MPEMVQPQVRLIAWTHFEPPQDVPWSTDADGGQALAEFAGRACYQSWKKPNPATATNAGYLAHILEVGHLSVLEHGSVSFYFTGVSRSFTHELIRHRHFSYSQLSQRYVPERDAAMVEPRVIAEDPELHKRFVEAAEASVRAYNELLEGLERHFVDEPNPTLRRKQARQAARAVLPNATETRIVVSGNYRAWRHFIAMRATEHADVEIRELAVECLRQLQRVAPNVFADFVISTLPDGTEVAASPLAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCU7</accession>
    <name>F4FCU7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_12385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12385"/>
    <dbReference type="EnsemblBacteria" id="AEB43591">
        <property type="protein sequence ID" value="AEB43591"/>
        <property type="gene ID" value="VAB18032_12385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12385"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024373_0_0_11"/>
    <dbReference type="OMA" id="CTVEDNR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313802" evidence="3">
        <location>
            <begin position="28"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="573" mass="58338" checksum="76A2F8F36B6824DE" modified="2011-06-28" version="1">MALGLLGATVAVTGVAVAASSPVPAAAAVAVTGQAAAGPQTVVPAALGPAVLGSAPLTKAGKKQCTVTDPRLREMSGLVATRSGYIVINDSTDQNDRKQVFYLNKDCQVVRNVGYTGAGPFDTEDLALSPDRTKLWIADTGDNVTSRERRERVAVWSMPVNGSKQPVLHRLSYPDGKPRDAEALLIGDDNLPLIITKVTSGKAEIFTPDGALKTGDTEPVPMKKLGDITLPRTDTENPLSTFGRVAITGAARSPDGSRVVLRTYADAFEYDVQNGDIVGALTTGTPRVTALADPFGEAISYSTDGKTFLTVSDAGHLDDDEPVDILSYTPSTEGPKNLAEDPDAAKKSSGQSFIDGLTLDDITYLIASVGVLGALLVGAGIYGILRARKRPGPAGKGRGRDDGPKPTGKDDDGAAGDRARSGGVYGGAATGGVYGGGSPNAERPGPARPGPVYGGRASGNGARPAGGGVYGGGGRAGEGVPGSGGRAGGGRPAGGGVYGGGGRPGGAGRAEPPRGGGRVEPPRGGGRAEPPRRGGGPTEPDYHGRRSGRYREDNSEPYGQPPGGTYGYRGDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD05</accession>
    <name>F4FD05_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18675"/>
    <dbReference type="EnsemblBacteria" id="AEB44837">
        <property type="protein sequence ID" value="AEB44837"/>
        <property type="gene ID" value="VAB18032_18675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18675"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_0_0_11"/>
    <dbReference type="OMA" id="RVWNYLL"/>
    <dbReference type="OrthoDB" id="1139523at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="28958" checksum="8AECCB880B00585B" modified="2011-06-28" version="1">MTVTDGEQNRPTLDTGVPQTARIWNYLLGGKDNFAVDREVGDQIISNLPQLAENARLSRAYLTRAVRYLAGEAGIRQFLDIGTGLPTADNTHEVAQSVNPQARIVYVDNDPLVLTHARALLVGTPEGATDYIDADLRNPQAILREAARTLDLSQPVALILMGILGHVESDDEAKSIINSIMAALPSGSYLAMYDGSDTSEAVTEAVRIWNISANPKYHLRSPERIAALFDGLELVEPGVVSVTRWRPDSTGPEPAAIDQYCAVGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD25</accession>
    <name>F4FD25_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733512.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18775"/>
    <dbReference type="EnsemblBacteria" id="AEB44857">
        <property type="protein sequence ID" value="AEB44857"/>
        <property type="gene ID" value="VAB18032_18775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18775"/>
    <dbReference type="eggNOG" id="ENOG503377Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1585768_0_0_11"/>
    <dbReference type="OMA" id="RVTWTEN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="168" mass="18316" checksum="BA878488F5EFDA0E" modified="2011-06-28" version="1">MGKAQVLAKVTEDLRRGHYHPAMQRLASLTAAHPDDLELRARRAALYRQVGNMVEAGRWGFLSEDATTPEVAAFERAHPSAWRRLRLLRVNADTVDHLGPVAGARLTRLIEQAGAEGLGRVTWTENGPEPAPPGFWSVTFPCLVATAFGVSAVGLAVIGLVTVIRWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD68</accession>
    <name>F4FD68_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_25000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25000"/>
    <dbReference type="EnsemblBacteria" id="AEB46098">
        <property type="protein sequence ID" value="AEB46098"/>
        <property type="gene ID" value="VAB18032_25000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25000"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_5_1_11"/>
    <dbReference type="OMA" id="GPIRTRC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="23455" checksum="A9B9D58219C7474D" modified="2011-06-28" version="1">MRQRHTEADSPRPVAAGQQDIAHQLQLAAAGDQVAWNDLVDRFSPLIWSICRQFGLSSADAADAFQLTWLRLLENLDTIQDPARLPGWLGTTCRRECLGLLRPTKRVRPTDDDRLLDRLRGPSSSADQPVLIADRNARLWREFGRLDARCQRILRLLLIDPDGDRVSYELVASALEMPVGSLGPIRGRCLARLRRLLDAEGISDALRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDF1</accession>
    <name>F4FDF1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylated-DNA-(Protein)-cysteine S-methyltransferase DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735998.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01390"/>
    <dbReference type="EnsemblBacteria" id="AEB47362">
        <property type="protein sequence ID" value="AEB47362"/>
        <property type="gene ID" value="VAB18032_01390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01390"/>
    <dbReference type="eggNOG" id="COG3695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_11"/>
    <dbReference type="OMA" id="MRTDSAD"/>
    <dbReference type="OrthoDB" id="1928537at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="104" mass="11120" checksum="6E25E90DE3B74770" modified="2011-06-28" version="1">MTPDEYVEAVLELVDRIPPGRVMSYGAVADALAERSGRASARLVGSIMARHGAAVGWHRVVNASGAMPARIAAEARARWLAEGTPLRQDRVDMRAAGWRPGEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDJ6</accession>
    <name>F4FDJ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06175"/>
    <dbReference type="EnsemblBacteria" id="AEB42359">
        <property type="protein sequence ID" value="AEB42359"/>
        <property type="gene ID" value="VAB18032_06175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06175"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_3_11"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="316" mass="33326" checksum="9AD79C44FB2C2DA6" modified="2011-06-28" version="1">MLGLLEAVEAELRDTVASADPFVTEAARHLADAGGKRFRPLLVALGAQFGDPSRAEIVSAAVVVELTHLATLYHDDVMDEAPVRRGAPSANSRWTNSVAILVGDYLFARAADVAAELGPEAVRLQARTFARLVHGQIAETVGPRAGDDPVTHYLRVIAEKTGSLIATSAHFGGLFSGATPEHVAALAGYGETIGVAFQLSDDLLDIASESTESGKTPGTDLREGVPTLPVLYALAADDTDAASVRLREILATGALTDDVLHAEALGLLRESAALKRARETVRSYAEDARAQLAPLPQIPARRALESLCDHIADRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDK1</accession>
    <name>F4FDK1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transmembrane anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731037.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06200"/>
    <dbReference type="EnsemblBacteria" id="AEB42364">
        <property type="protein sequence ID" value="AEB42364"/>
        <property type="gene ID" value="VAB18032_06200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06200"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056526_1_0_11"/>
    <dbReference type="OMA" id="ARPSPQN"/>
    <dbReference type="OrthoDB" id="1740922at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="230" mass="24699" checksum="14148B979FE6F337" modified="2011-06-28" version="1">MSRCDFAYDDGAYVLGALSPADRAAYERHLVDCPACQQSISEIAVLPGLLGRLDPTSLEQFLPPPENPRVPELLSAARERRRRERQANRLRYAVIGLAAAALALVVGFGTATMLPGQEPNAPLAQVRMVQMRPVAGSVPLHAEIGLTGTNWGTEVTMTCGYDERSGYGKANAFRLVAHAADGSQEQIGSWLAAPGDDLRISGATRFTNAELVRLELVRADGTVVLAYDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDN7</accession>
    <name>F4FDN7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein, TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_06380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731073.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06380"/>
    <dbReference type="EnsemblBacteria" id="AEB42400">
        <property type="protein sequence ID" value="AEB42400"/>
        <property type="gene ID" value="VAB18032_06380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06380"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_46_2_11"/>
    <dbReference type="OMA" id="VYQFFPD"/>
    <dbReference type="OrthoDB" id="1309950at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041674">
        <property type="entry name" value="TetR_C_22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17928">
        <property type="entry name" value="TetR_C_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="23904" checksum="173F8568A54B8EBF" modified="2011-06-28" version="1">MLDACAELVDEVGYEGLTTTLLAERAEVAIGSVYQFFPDKRAIVQALTLRTMEAYLQRLDERFASDDLTHWWDGVDAGIDEYITMHRTVPGFRTLHFGDVVDLHLLDEQRDNNGVIADQLARVLTERFGLADVPDLQFHLEIAVEVADALIKLAFRRTSDGDERVLVEAKALIRDYLHRQVDARGDAGHRPVVQPAKPADDQIIDSAEPAAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDW3</accession>
    <name>F4FDW3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12650"/>
    <dbReference type="EnsemblBacteria" id="AEB43644">
        <property type="protein sequence ID" value="AEB43644"/>
        <property type="gene ID" value="VAB18032_12650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12650"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016537_0_0_11"/>
    <dbReference type="OMA" id="PFIVWRV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="599" mass="65723" checksum="9814A857D0937B55" modified="2011-06-28" version="1">MDSEVAGGGSDQAYATPKRRFRWTPRRMDLAVFGGFLLVAVWVTSQIWADPAGRVASLYSSDPAQVQFFLAHSVRVVLHGEFPFFTEQFNYPDGVNLMANTAILALGIPMVPVTLLFGPAVTFVVLVTLALAGTASAWYHVLSRHVVSNRLAAVVGGWFCGFSPAMLSHASWHPNIISQFLLPFIVWRVMVITRSTRPYRDGALLALLVTAQAFINEEILLFTAMGCGIFLIAVVVQRPALWSAAWRPLGKAVATCTVIAGALLAYPLYIQFAGPMAYHGLSDAVRDYGNDIAAYLAPGSPTIGGNQRANVNLAPNYSEENAFFGWSLALIAVGIVLWLRREVLVRALAATAGFYAVLSLGERITWWDRELMVGPWEWLVRLPLLDAVVPTRFGMITSVVVAILLALAIERSRTLPLDPRTLRTLTAGGLVLALLPIAPMPLPMTTRPPVPDFITSDRWRAYVGPDQTLVPIPVPNMGNTHGMRWAAATNLDFKMPGGYFLAPRNGNTGDPGRFGGRPSGIGRLLEEVATTGRTPELNDRQRRRSLDELRHWRAAVLVLPVSQPHSEPLRQTVEQLVGPARQELDVWVWDVRALTDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDY8</accession>
    <name>F4FDY8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_12775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732337.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12775"/>
    <dbReference type="EnsemblBacteria" id="AEB43669">
        <property type="protein sequence ID" value="AEB43669"/>
        <property type="gene ID" value="VAB18032_12775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12775"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_11"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="OrthoDB" id="1650261at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PTHR46081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="15486" checksum="BDD95E5F1E6698FB" modified="2011-06-28" version="1">MSLPDSELPRTEDEWRVRLSPEEFRVLREHGTEPAWTGEYVDTKTPGMYRCRACGAELYPSDTKFDSHCGWPSFDDAIPGAIKEIEDNSLGMRRTEIRCARCDSHLGHVFRGEGFTPKDTRHCVNSLSIRLDPSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEA6</accession>
    <name>F4FEA6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734824.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25370"/>
    <dbReference type="EnsemblBacteria" id="AEB46172">
        <property type="protein sequence ID" value="AEB46172"/>
        <property type="gene ID" value="VAB18032_25370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25370"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_10_0_11"/>
    <dbReference type="OMA" id="QGVDCFK"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="743" mass="82221" checksum="399849C6D43A4CDA" modified="2011-06-28" version="1">MKFTDGYWQLRPGVTVLRPGAVESVEPDERSFTVFAPIGRITGRGDTLNRPVVTVRFFSPAPGVVGVTVGHHSGGLPKQPRFVLAEDTDHPVQVEVTGLSARLTTGELTVRVALTGPWQVDFLRGDRLVTSSTERSIGVVTDADGQKYVHDRLALGVGETVYGLGERFGAYVKNGQTVEIWNADGGTASEQAYKNVPFYLSSAGYGVFVDHPEHVSFEVGSEVVSQTQFSVPGQSLTYHVIDGPSPKEVLRRYTALTGRPARVPAWSYGLWLSTSFTTSYDEKTVTEFIDGMAERDLPLSVFHFDCFWMRQFHWVDFIWDPATFPDPEGMLRRLHERGLKVCVWINPYIAQRSYLFEEGRQAGYLVRNPDGSIWQWDKWQAGMALVDFTNPDAARWYADKLKVLLDMGVDCFKTDFGERIPTDVIWHDGADPQRMHNYYSYLYNKTVFELLEAERGTGEAVVFARSATAGGQQFPVHWGGDCESTFVAMAESLRGGLSLAASGFGYWSHDIGGFEGTPDPAVFKRWIAFGLLSSHSRLHGSGSYRVPWAYDDEAVEVLRRFTRLKLSLMPYLAAAADEAHREGIPVMRPMILEFPDDPTTAYLDRQYMLGPDLLVAPVMSPDGQVTYYVPAGTWTNLMTGAQVTGPGWVNEKHGFDTVPVLARPGAVIPFGSVTDRPDYPWADGVQLRMYAPAQGQRTRVRIPSPDGGPGTEFEVRYQDGTATAEVVAGASSGYGCEVTEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEJ2</accession>
    <name>F4FEJ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01750"/>
    <dbReference type="EnsemblBacteria" id="AEB47434">
        <property type="protein sequence ID" value="AEB47434"/>
        <property type="gene ID" value="VAB18032_01750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01750"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043786_0_0_11"/>
    <dbReference type="OMA" id="YRPDREW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="339" mass="37723" checksum="5BCD6EFDF9E869CF" modified="2011-06-28" version="1">MMVREWDPRNASSAEIASLLDTLNAVLATDLPQDPPWRETCLREYLAEVMPGERRISWVAQAEPAADGTPGPILGHVHVLLLGSIGVLEVLVHPSVRRGGLGRELVLRAARRVYQEGFESIGVEVVGGTPAIAFYESLGFAREYVETRSVLDLSGVDWAELAEMSTGVGAGYHVQFHPGGPPDELIEAYARAKAEIRDIEDGELRPSSYDPQRLRDSLDCLHRRGMKPYIVLALHEQTGEVAGLTEVVVPVQHPTRADQYDTIVVQDHRGYGIDRAIKARMLLELRSTEPQLTEVQTWNAQANETMLKVNAELGYRPDREWCEYSVDVADLVHRLDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEV8</accession>
    <name>F4FEV8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_06890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731175.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06890"/>
    <dbReference type="EnsemblBacteria" id="AEB42502">
        <property type="protein sequence ID" value="AEB42502"/>
        <property type="gene ID" value="VAB18032_06890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06890"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="HDPLDAM"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="10">
        <location>
            <begin position="287"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="361" mass="38869" checksum="E144F6D7412E64F9" modified="2011-06-28" version="1">MTWLLDAHLVVDRGGFRLDLPLTIAPGEVVALLGPNGAGKTTALRALAGLHPLSAGHLTLAGRDLDRPGHRAWVPTERRPIGVVFQDYLLFPHLSALDNVAFGPRRHGLNRQQARQRATAWLARMNLTEQARRKPRELSGGQAQRVALARALAVDPALLLLDEPLAALDARTRLDTRAQLHQHLAAHPGATLLVTHDPLDALVLADRLVIIEDGRVVQEGDAATITAEPRTDYVARLVGLNLYRGHATGHQVRLVDGHVLTIGDRYEGQVFVAFAPTAVALYPHRPEGSPRNTWPATITGIQRHGDNLRIQLTGPIEVAADVTPAAAAHLKLVPGQPVWAAVKATETRAYPAVTGAGVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEW0</accession>
    <name>F4FEW0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731177.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06900"/>
    <dbReference type="EnsemblBacteria" id="AEB42504">
        <property type="protein sequence ID" value="AEB42504"/>
        <property type="gene ID" value="VAB18032_06900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06900"/>
    <dbReference type="eggNOG" id="COG4954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1843035_0_0_11"/>
    <dbReference type="OMA" id="KGARMHP"/>
    <dbReference type="OrthoDB" id="1746879at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018988">
        <property type="entry name" value="DUF2000"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09391">
        <property type="entry name" value="DUF2000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="143" mass="15547" checksum="D9664DD2172687EE" modified="2011-06-28" version="1">METGTEPVRFDTKIAVLLRDDLPVWQRLNMTAFLVSGISRAAPEVIGEPYADADDTPYLPMFRQPVLVFAGSKEVLTAAHQRAVGRNLPLAVFTSDLFGTGNDRDNRAAVRAVGRADLDLTGLAVYGPRNGVDKVIKGARMHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF27</accession>
    <name>F4FF27_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoketolase</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_13125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732407.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13125"/>
    <dbReference type="EnsemblBacteria" id="AEB43739">
        <property type="protein sequence ID" value="AEB43739"/>
        <property type="gene ID" value="VAB18032_13125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13125"/>
    <dbReference type="eggNOG" id="COG3957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_11"/>
    <dbReference type="OMA" id="LSTMDHC"/>
    <dbReference type="OrthoDB" id="45239at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="XFP_N" evidence="7">
        <location>
            <begin position="11"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="6">
        <location>
            <begin position="587"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="797" mass="89258" checksum="401FA6106E406248" modified="2011-06-28" version="1">MDTALNPKSTLTDEELRRLDAYWRAANYLTVGQIYLLDNPLLREPLAPEHVKPRLLGHWGTSPGLNLIYAHLNRVIVARDLSAIYITGPGHGGPALVANSWLEGTWSERYHGIDRDEAGMARLFRQFSFPGGIPSHVAAEVPGSIHEGGELGYALSHAYGAAFDNPDLLVACVIGDGEAETGPLSGSWLSNVFLNPARDGAVLPILHLNGYKIANPTVLDRIPESDLLDMMRGYGYQPYVVAGDEPAAVHELLAATFDRALDEIAEIQRQARSGGTVTRPRWPMIVLRTPKGWTGPSEVDGKQVEGTYRAHQVPLSQVRTNPAHRAELERWLRSYRPEELFDATGAPVAELTALPPTGDRRMSANPVTNGGQVLRDLTLPDFRDYAVEVPRPGATVAGATGELGKWIRDVIVANPQTFRLFGPDEVASNRLQAAFEVTDRAWMARTVPGDDHLSPDGRVMEVLSEHLCQGWLEGYLLTGRHGIFTSYEAFIHIVDSMVNQHAKWLKVTRDIPWRLPVASLNYLLSSHVWRQDHNGFSHQDPGFIDHVMNKKAEVVRVYLPPDANTLLSTMDHCLRSRHYINVVVAGKQSAPNWLTMTEAVQHCRRGLGIWDWASTDGDSEPDVVLACAGDVPTLETLAAADLLRQHLPELKVRVINVVDLMRLQPPSEHPHGLPDNEFDTLFTRDKPIIFAYHGYPWLIHRLTYRRTNHDNLHLRGYKEEGTTTTPFDMVMLNDLDRFHLVIDVIDRVPGLAARAAHLRQEMTDARQSCRDYTRQYGEDDPRVAEWRWVRETDQTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF64</accession>
    <name>F4FF64_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19335"/>
    <dbReference type="EnsemblBacteria" id="AEB44969">
        <property type="protein sequence ID" value="AEB44969"/>
        <property type="gene ID" value="VAB18032_19335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19335"/>
    <dbReference type="HOGENOM" id="CLU_3159097_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="48" mass="5028" checksum="5601A7D89D5A35AC" modified="2011-06-28" version="1">MLLEADRIAPAEVRHRPAARQVLADTLSHPDAPATILALAATLGVTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF81</accession>
    <name>F4FF81_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733641.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19420"/>
    <dbReference type="EnsemblBacteria" id="AEB44986">
        <property type="protein sequence ID" value="AEB44986"/>
        <property type="gene ID" value="VAB18032_19420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19420"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_11"/>
    <dbReference type="OMA" id="PHEEMGR"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="348" mass="37319" checksum="7A72CE3E7576613B" modified="2011-06-28" version="1">MGRDRATLADVAKRAGLSKTAASMVLNGREGTRLSAEAHQRVFAAAEELGYRPNVAARSLRTRKTATIAFVSDIVATTRFAGGLIRGALDAARERDHVLLITETQGDATFERYAIEAILDRQVDGVIYAAMATRRLSVPPAILSGPVVLLNATSAEELPCVLPDDEGAGVAIAETLLGYGHRDRIALIGRNRQKERDPEISLAAEARLRGIRATLAAAGVSLLVESFCPEWLPEHGYTATRALLARPDRPTAIICMNDRLAFGAYQALGEAGLTIPDDISVISFDDDPTASWLRPRLSTAALPHEQMGRRAVELLLDGEAPAQSLVPMPLRRRRSVAAPAGAPAVEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFH9</accession>
    <name>F4FFH9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifU family SUF system FeS assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734932.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25915"/>
    <dbReference type="EnsemblBacteria" id="AEB46281">
        <property type="protein sequence ID" value="AEB46281"/>
        <property type="gene ID" value="VAB18032_25915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25915"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_11"/>
    <dbReference type="OMA" id="MKLDSMY"/>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="158" mass="16821" checksum="5DB7EC8023548A61" modified="2011-06-28" version="1">MQLDALYQEIILDHYKHPHGRGLRDAAEPTDRVAEAHHVNPTCGDEVTVRVATDGEVLHDVSYDGMGCSISQASASVLHELLTGREAAAAFQVHEAFVALMSGRGQVTPDEEVLGDGVAFEGVARYPARVKCALLPWMAFKDAAARAGVGASPTEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFP2</accession>
    <name>F4FFP2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736153.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02175"/>
    <dbReference type="EnsemblBacteria" id="AEB47519">
        <property type="protein sequence ID" value="AEB47519"/>
        <property type="gene ID" value="VAB18032_02175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02175"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_1_1_11"/>
    <dbReference type="OMA" id="RANPHKA"/>
    <dbReference type="OrthoDB" id="1329125at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="334" mass="34609" checksum="31622243B41F2CF6" modified="2011-06-28" version="1">MTPELIAVLAVIGVALVFDYTNGFHDAANAIATSISTRALTPRVALGMAAIGNFIGAHFGAEVAKTVGSGLVELPTGVSSLGIVFAGVIGAIVWNLITWYFGLPSSSSHALIGGLVGSTVAASGTVLWKGIGESVIIPMILSPMVGFILGYIVMIGVQWLFRNGHPGKLNRGFRWAQTASAAAMSVGHGMQDAAKTIGIVVLALFVGGYQSDPTHIPEWAFWTSAAVLAAGTYAGGWRIIRTLGRKIIDLRPPEGFAAETVASGVLYFNALVLGAPISTTHTITSAIMGVGATKRLSAVRWGVAGNIVGAWILTFPAAGSIGALMYFLVRPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFP7</accession>
    <name>F4FFP7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736158.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02200"/>
    <dbReference type="EnsemblBacteria" id="AEB47524">
        <property type="protein sequence ID" value="AEB47524"/>
        <property type="gene ID" value="VAB18032_02200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02200"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155801_0_0_11"/>
    <dbReference type="OMA" id="MGKRLSW"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12169" checksum="35602790BE0A3030" modified="2011-06-28" version="1">MTADHNLDSGLPIRLLHDRVLVRMEGSEGERRSTAGIVIPATAAVGKRLAWATAVGVGPNVRSIVSGDRVLFDPDDRSEVELHGRGYVLLRERDVHAVAAERVEEDATGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFS6</accession>
    <name>F4FFS6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_02345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02345"/>
    <dbReference type="EnsemblBacteria" id="AEB47553">
        <property type="protein sequence ID" value="AEB47553"/>
        <property type="gene ID" value="VAB18032_02345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02345"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_0_1_11"/>
    <dbReference type="OMA" id="MDFGCIT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="250" mass="26282" checksum="FB3C7C26F62D8AE8" modified="2011-06-28" version="1">MDSVQSPDWPVAPQGALSANSATARYGGPAPTPPPVVGRASLPPPQPYHPPAAAPAATGTPSRPAPPIPVKILIAGGFGVGKTTTVASISEIDPLTTEAEMTIAGIGVDDPGQRFDKTTTTVAMDFGCVTIDRSLKLYLFGTPGQARFGFMWDDLARGALGALVVVDSARMDDCYPAIDFFERAGLPFVVGVNAFDGRLAHDLGAIRWALAIGDHVPLVQFDARDRLSVRDALLVVLDRALARATRDKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFX7</accession>
    <name>F4FFX7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07165"/>
    <dbReference type="EnsemblBacteria" id="AEB42557">
        <property type="protein sequence ID" value="AEB42557"/>
        <property type="gene ID" value="VAB18032_07165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07165"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064948_0_0_11"/>
    <dbReference type="OMA" id="SIMDFTR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="67"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="35957" checksum="2910535009BE4B34" modified="2011-06-28" version="1">MTALTINGLAALSAAGDRPEALAERATALAGDIHPGVPVGGIVTEELPRPEGHALLDFDVRARLGRRGTSFYDRATALAVVACGDALTDSGLTVDDTNRARVGVVLGTTVGSLKSTSDYTRETLVQEKPYLVNPMLFPNTVMNCAAGQAAIRHGLKGINATVTGGPLAFFNALRYAGNAIRRGYVDTMLVGAVEEFSAHRAWASASGPTGGEVPAGEGAAVFVIGGGADSVGRTTICAVTTGYGPDGTAEQALTDCVARALHVAGAAPTDVTLLATSETRTAGTRPQRAAALRALDGHVPAEFVLSRVAGDCGAATPALALAAVLRLPADGDRSGLILLTAHGTDGGVGAALVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG68</accession>
    <name>F4FG68_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732479.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13500"/>
    <dbReference type="EnsemblBacteria" id="AEB43812">
        <property type="protein sequence ID" value="AEB43812"/>
        <property type="gene ID" value="VAB18032_13500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13500"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_7_2_11"/>
    <dbReference type="OMA" id="RWGHAVM"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="187" mass="20032" checksum="48990B18F8ECFD94" modified="2011-06-28" version="1">MSSTEVLTATAADRPQVVSALVAAFADDPVLRHLFPDPQDYPRLAAVFFGHLFDKRVGLGTVWTIGPGASTAVWQPPSGGDPTSTDLLETHLPADALARTRAYDHAVHAALPAEPFWYLGVLGTRPDSAGRGLGRAVMAAGLRRAAADGLPAILETSNPANVEFYRRAGWQVVGRVDEPLPIWVMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG80</accession>
    <name>F4FG80_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile acid:sodium symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732491.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13560"/>
    <dbReference type="EnsemblBacteria" id="AEB43824">
        <property type="protein sequence ID" value="AEB43824"/>
        <property type="gene ID" value="VAB18032_13560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13560"/>
    <dbReference type="eggNOG" id="COG0385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034788_0_1_11"/>
    <dbReference type="OMA" id="MEIGIHN"/>
    <dbReference type="OrthoDB" id="1493959at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="298" mass="30606" checksum="E4D6CDA6CDDFC0E4" modified="2011-06-28" version="1">MDSALTLIGLPIALGVIMLGLGLGLTVADFRRVAHHPKAAVIALACQVLLLPALCFGLVLAFGLPPELAVGMMLLAASPGGTTANLYSHLFGGHVALNITLTAINSVLAVFTLPIVVNLSAAYFLGDARSIGLQFDKVLQVFAIVLVPVAIGMLVRAWVPRVAESLNRPVRILSVVVLVAVIAGAVVGERDNLADYFVSVGLAVLAFNLVSLGIGYGVPRLAGIDRGAAKAAGFEIGIHNSTLAITIALSPALLNSSQMAIPAAVYGVVMFFTAAAFGYLVNRVGTRTSTSPSGATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGL2</accession>
    <name>F4FGL2_MICM1</name>
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        <submittedName>
            <fullName evidence="6">Extracellular solute-binding protein family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_26245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734998.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26245"/>
    <dbReference type="EnsemblBacteria" id="AEB46347">
        <property type="protein sequence ID" value="AEB46347"/>
        <property type="gene ID" value="VAB18032_26245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26245"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_1_11"/>
    <dbReference type="OMA" id="QPTKWDG"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307715" evidence="4">
        <location>
            <begin position="26"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="63"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="31239" checksum="2F812D92AA5EF919" modified="2011-06-28" version="1">MFNLKGRRRAVIGVAGAALLTLSMAACGEQESSNEPGTGPSVSAAPDNDLAAKVPDAIKADGVIKVGTDATYAPAEFLDTDGSTVIGFDVELFNAVAQKLGLKAEYESAPFDAILPGVQSGKYEIGVSSFTINADRLQSVNMVSYFSAGTQWATKAGNPAQVDPDNACGKKIAVQVGTVQLDDITARSKACTDAGKPEITIDQYQAQSDATAAVVSGKNDAMLADSPVGAYAVKQSNGQLEVLGDIYESAPYGYAVPKDQTAFAEVLKEAVQAVIADGSYKAALEKWGVEGGAITTSELNPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGM0</accession>
    <name>F4FGM0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735006.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26285"/>
    <dbReference type="EnsemblBacteria" id="AEB46355">
        <property type="protein sequence ID" value="AEB46355"/>
        <property type="gene ID" value="VAB18032_26285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26285"/>
    <dbReference type="eggNOG" id="COG3780">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095291_0_0_11"/>
    <dbReference type="OMA" id="YEYPRYF"/>
    <dbReference type="OrthoDB" id="1216599at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="1">
        <location>
            <begin position="72"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="28163" checksum="1DCAD272D45E54FA" modified="2011-06-28" version="1">MHPPEIRARVRALRARGHNIRSVARSLDLPYTTVWHWCVDRPEPTQVNSAVRCFRCRPELTGPTDPTAYAYLLGLYLGDGHLVTSDRVPVLRIYCTDTWPNLIEACDAAMRAVLANRIQRIQKQGCVAVQSTGKHWPCLIPQHGPGKKHQRPIVLAAWQRDILTSHAGHFVRGLFHSDGCRVSNRVTVRGREYAYPRYMFVNESSDIMGLCQWALDLLGIAWAMNRRNSLSVARREAVAALDRHVGPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGS5</accession>
    <name>F4FGS5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02505"/>
    <dbReference type="EnsemblBacteria" id="AEB47585">
        <property type="protein sequence ID" value="AEB47585"/>
        <property type="gene ID" value="VAB18032_02505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02505"/>
    <dbReference type="eggNOG" id="ENOG5031S4S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151362_3_0_11"/>
    <dbReference type="OMA" id="EYAHDRI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307895" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="85" mass="9446" checksum="33ABB4665162E49C" modified="2011-06-28" version="1">MTRPHLPLRPLWLCRACAAPWPCATARLTLIAEYAHDRIALSVYLCAVLHEAAADLYRLDPDEGPTPAALFARFLAWVPRPGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGV9</accession>
    <name>F4FGV9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">VAB18032_02675</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02675"/>
    <dbReference type="EnsemblBacteria" id="AEB47619">
        <property type="protein sequence ID" value="AEB47619"/>
        <property type="gene ID" value="VAB18032_02675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02675"/>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_2_0_11"/>
    <dbReference type="OMA" id="WNNAIME"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="14">
        <location>
            <begin position="51"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB47619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="312" mass="33540" checksum="F8601B84A9ACC728" modified="2011-06-28" version="1">MGTGARDIISDAMTESTFAGLVSRWYEHNARDLPWRKPDVSPWAILVSEVMLQQTPVVRVLPAWHAWLDRWPTPAALAQDSPAEAIRMWGRLGYPRRAVRLRDCAVAIVERHGGAVPDRLDQLLALPGVGTYTARAVAAFAYGQRHPVVDTNVRRVVCRAVAGEPDAGPATRPADLVATEELLPVEPAAAALASAAIMELGALICTARSPRCPACPVESICAWRASGRVAPAGPTRRPQRYAGTDRQVRGLLLGVLREATGPVPHQRLDQVWDDDVQRARALAGLVTDGLVEPVGEASFRLIGDGPPAPVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH01</accession>
    <name>F4FH01_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731288.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07465"/>
    <dbReference type="EnsemblBacteria" id="AEB42615">
        <property type="protein sequence ID" value="AEB42615"/>
        <property type="gene ID" value="VAB18032_07465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07465"/>
    <dbReference type="eggNOG" id="COG3477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123832_0_0_11"/>
    <dbReference type="OMA" id="ISWAPVY"/>
    <dbReference type="OrthoDB" id="1825849at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="168" mass="18110" checksum="3C1FB70716843A25" modified="2011-06-28" version="1">MRLTETIKDLAVAPAAGYAATKVMDPISMKLYQLESDADRKREDTARPGLPYEIAAAKTLRLLGVDLPGTARQRAGMVLHYGLAISWAPVYSVLRRTIGLNPVLAGLASGAAMSLIVDEGLTPALRFSAPNRAYPLATHLRGFVAHLAYGLTVAAVTETAWKLTRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH25</accession>
    <name>F4FH25_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731312.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07595"/>
    <dbReference type="EnsemblBacteria" id="AEB42639">
        <property type="protein sequence ID" value="AEB42639"/>
        <property type="gene ID" value="VAB18032_07595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07595"/>
    <dbReference type="eggNOG" id="ENOG5031WGR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249441_0_0_11"/>
    <dbReference type="OMA" id="PRRWDRQ"/>
    <dbReference type="OrthoDB" id="2199564at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="24048" checksum="C3CD27B261EE5DC9" modified="2011-06-28" version="1">MSTPTLIGVAASRGRYSARYLQFGEEPEKLVPLLRRIWTDTFGRDTNAMAAALLAHNWWTLAINPKPRRWDRQPPVAGLGYPADTGTIRQGLLREDIDGALEWLYLLHLDQRRLVVYEASIHGHWLRHSAHHLDPVEDLFVTAPALDEGGPEMTVCTACGAVDEIDHIEVPSMAGYGHDTVTSCTRCGSSVATDPMFGDHVTRKPWPPPSTTTDGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHN2</accession>
    <name>F4FHN2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_26631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735052.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26631"/>
    <dbReference type="EnsemblBacteria" id="AEB46401">
        <property type="protein sequence ID" value="AEB46401"/>
        <property type="gene ID" value="VAB18032_26631"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26631"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="VMVPQDG"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="30"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="348"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="589" mass="62771" checksum="1FB680FF95250945" modified="2011-06-28" version="1">MNAASERVESTWATLRRGLALSPELRVGLAGTLGLALVYMLGRVAVPVAVQQGIDRGIVGGLDLNALFVVVAVTAAVLVVTTACGYLMMRRLFTVSETALAGVRVRAFRHVHDLSMLHQQSERRGSLVSRVTSDVDQITQFLQWGGVILLVNLGQLAVTTVVMLAYSWQLTLVVFAAFVPAVLVIRLLQRRLAAAYGVVRQRTGALLGAVGESVVGAPVIRAYGIAGRTARRLDQAIDSQRQAQQKAIRISILGSSVGELAAGVALAGVVVVGVLLGADQTLSIGEVTAFLFLVTLFIQPVQIATEVLNEAQNAIAGWRRVLDVLDVSPDVADPGEQGRELPPGPLDIRFAGVSFAYPNGPTVLHDVSLEIPAKSRVAVVGETGSGKTTFAKLLTRLMDPTQGDVLLSGVPLTDVRFESLRSRVVMVPQDGFLFDATVADNVRFGRPELTDEQLTAAFTELGLSDWLDGLPAGLATGVGERGEALSVGERQLVALARAYVADPDLLVLDEATSAVDPATEVRLQRTLDAVTRGRTTLAIAHRLSTAQSADEVIVVDRGRIVQRGPHDELVADPDSVYGLLYASWLEQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHS1</accession>
    <name>F4FHS1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="8" type="ordered locus">VAB18032_26836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26836"/>
    <dbReference type="EnsemblBacteria" id="AEB46440">
        <property type="protein sequence ID" value="AEB46440"/>
        <property type="gene ID" value="VAB18032_26836"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26836"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_0_0_11"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="43136" checksum="966659F2C0B365F5" modified="2011-06-28" version="1">MGIWRYDGTASSDEQDAEENKVKPVGVDMGELRGTHVPVLLERCLELLAPALGRGGRTVHVDATLGLAGHAEAVLQAHPETILVGLDRDTEALEHARVRLARFADRVHLEHAVYDELPEVLDRLGYPTVDGILFDLGVSSLQLDAPDRGFAYAQDAPLDMRMDQTRGVTAEEVVNTYTHPELARVLRVYGEEKFAGRIASAIIRERERVRITSSARLAELVRESIPAPARRTGGHPAKRTFQALRIEVNRELAVLETALPAALDRLSVGGRLVVLSYHSLEDRLTKQALADRVRSTGPIDLPVELPGSEPTFRLLSRGAELPGEAEVAANPRAASVRLRAAERIDPQARQQGRTDRERYRRRVKAMHQPGTGSAVGSESGPRPGETTDEEGEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI50</accession>
    <name>F4FI50_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
            <plasmid evidence="1 2">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB48014">
        <property type="protein sequence ID" value="AEB48014"/>
        <property type="gene ID" value="VAB18032_30254"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30254"/>
    <dbReference type="eggNOG" id="ENOG5030NQ5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3067420_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB48014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="53" mass="5766" checksum="B6AD6A394BA6F648" modified="2011-06-28" version="1">MAAPDAESLPDDVAAGLQSQIDDLTAVLEHHQRLFESLRTRGLLPTEPDDGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI57</accession>
    <name>F4FI57_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
            <plasmid evidence="1 2">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30289"/>
    <dbReference type="EnsemblBacteria" id="AEB48021">
        <property type="protein sequence ID" value="AEB48021"/>
        <property type="gene ID" value="VAB18032_30289"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30289"/>
    <dbReference type="eggNOG" id="ENOG5030RGE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2060469_0_0_11"/>
    <dbReference type="OMA" id="VELMGVH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB48021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="119" mass="11962" checksum="F2230719E5657096" modified="2011-06-28" version="1">MHRVTVRLSTEELAAVTANAAAARMAVAAYLAEAGAAPLVPAANAPDGPGETSALLVELMGVHRQVRGAATNLNQAVARLHATGEPAGDLAASAAYVARIAARVDELVTAIAAAQTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F113</accession>
    <name>F4F113_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42667">
        <property type="protein sequence ID" value="AEB42667"/>
        <property type="gene ID" value="VAB18032_07735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07735"/>
    <dbReference type="HOGENOM" id="CLU_3013041_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="56" mass="6125" checksum="61D3BB9019D9E309" modified="2011-06-28" version="1">MQVVVEKHPALLANMTSGHHGTWVIPQVRFSDHYVADFLVASDTSAGLRGVCCTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F126</accession>
    <name>F4F126_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07800"/>
    <dbReference type="EnsemblBacteria" id="AEB42680">
        <property type="protein sequence ID" value="AEB42680"/>
        <property type="gene ID" value="VAB18032_07800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07800"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_0_11"/>
    <dbReference type="OMA" id="QMETCAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="24701" checksum="2B4ABB661D73CF29" modified="2011-06-28" version="1">MVEESSRIAGPASLRADARRNQERILVSARAVFAEHGIDAPMATVARRAGVGVATLYRRFPTRDALVRAAFAQQMETCARALTEALADPDPWRGFQRLVETACELQREEQGFSAAFVAAFPDSRVEHAQAREQAERDLLTLVRRAQAAGALRADFHPSDLAVALLAHCGLVTALPRDSAASRRLVAYLLQSFRAEAAHGALPPPSTLSLRSLPLAADNAPRQRPFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F175</accession>
    <name>F4F175_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Undecaprenyl-phosphate galactose phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732578.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13995"/>
    <dbReference type="EnsemblBacteria" id="AEB43911">
        <property type="protein sequence ID" value="AEB43911"/>
        <property type="gene ID" value="VAB18032_13995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13995"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_4_11"/>
    <dbReference type="OMA" id="QVQNIDM"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="23621" checksum="2C8C140C8F6719A1" modified="2011-06-28" version="1">MIAAALLALLAPVFAAVALLVAGGLGRPVLFRQRRVGRHGELFEVIKFRSMLPPDPRRGLTGDANRLTPLGRWLRSTSLDELPSLWNVLRGDMSLVGPRPLLPEYLSRYSPTQARRHEVRPGITGLAQVRGRNGLSWEEKFDLDVEYVDRRSLLMDLSILGATVRTVLRRDGISAPGVATAPEFLGTPAGTAPTDAPEVTLSTNPSGTVTAQQGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F194</accession>
    <name>F4F194_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="2" type="ordered locus">VAB18032_14090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14090"/>
    <dbReference type="EnsemblBacteria" id="AEB43930">
        <property type="protein sequence ID" value="AEB43930"/>
        <property type="gene ID" value="VAB18032_14090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14090"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_0_1_11"/>
    <dbReference type="OMA" id="PDPWHKS"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="220"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="241" mass="26743" checksum="00BEDEC21F57BC75" modified="2011-06-28" version="1">MTSTEPISAGTAPHPARAIRTFHPRRGRMSDRQTTALQQLWPVYGLRVCDAVSSDPAVPFDAAGLFGRRAPLVVEIGSGMGDTTVEMAAADPDRDYLAVEVHTPGIANLLDLVHRRELRNVRVAEGDAVELLRAMPADSLDAVHVFFPDPWPKSRHHKRRLIQPTHVALLRSRLAVGGTLHCATDWAEYAEAMRVTLDADPGLVNLHDGYAPRPAHRPVTRFERRALRAGRPIADLIYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1F8</accession>
    <name>F4F1F8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, laci family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20435"/>
    <dbReference type="EnsemblBacteria" id="AEB45187">
        <property type="protein sequence ID" value="AEB45187"/>
        <property type="gene ID" value="VAB18032_20435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20435"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="VMDVELH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="357" mass="37652" checksum="97B310E031A77F43" modified="2011-06-28" version="1">MCVAAVQHERGAVSGRGRVASGQPTIADVARHAGVAVSTVSYVLSGKRAISEVTRSRVLSSIRVLGYHPNAGARALASRRSNVIALVLPLRSGIQVPVVMQFATAVVTSARRHDHDVLLLTSDEGPEGLRRIAAGALVDGVLVMDVELHDVRVPLLRQLGRPSVLIGLPADTSELTCVDLDFHRAGQLCVEHLAGLGHRRIALLGAPGAVYDRGTGFAHRTRAGVIEAAARHGVDAVTMPCEENAADVHHRVAGLFARHPDISALIVQNEAAVAPMQAALAASGRRVPDDVSVVAVCPDQFADHASPRLTCVPVPAEEIGRQAVSLVMGKLRDEPVPEVTLLPPRLTVRDSTARPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1R7</accession>
    <name>F4F1R7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fad-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_27096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735143.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27096"/>
    <dbReference type="EnsemblBacteria" id="AEB46492">
        <property type="protein sequence ID" value="AEB46492"/>
        <property type="gene ID" value="VAB18032_27096"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27096"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_8_3_11"/>
    <dbReference type="OMA" id="DCYERET"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="468" mass="52585" checksum="2474D0B87775FF5E" modified="2011-06-28" version="1">MPTPTEHGRPDAETTTLARSHDGRPIADRGDTVCVIGAGASGLTAIKNLAEHGFGVDCYERETGIGGAWNWRHDRSPVYASTHLISSRPFTQFPDFPMPDDWPDYPHHSQLLSYFERYADHFDLRRHIWFGTEVVRIEPVAGDRWDVTTRSTGGYGPERTSRYAAVLIANGHNWSPKLPRYDGLEQFRGEVMHASSYKDPAQLRGKRVLVVGAGNTGCDIAVEAAQQASHCWHSTRRGYWYAPKYVFGRPADQVNDTLLALRVPLRLRQWLYHRTLRLTVGDLTRFGLPAPDHRVYETHPIANSQLVYHVGHGAITPVPDVARLHPHSVELTDGRQIDPELVVFATGYLPRFEFLDAKILGDDEGVGRPRLWLNAFVPNHPTLAVAGLLQPDSGLFPLVHWQAVLFARLLQARITRPDRADAFAGRVSAGAGERYSGRVKDSTRHWFEVGHVDYLRALERALRDLEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1U0</accession>
    <name>F4F1U0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_27211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27211"/>
    <dbReference type="EnsemblBacteria" id="AEB46515">
        <property type="protein sequence ID" value="AEB46515"/>
        <property type="gene ID" value="VAB18032_27211"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27211"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031114_2_0_11"/>
    <dbReference type="OMA" id="WNYGPYD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="8"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="532" mass="59256" checksum="B5686B23F41EB346" modified="2011-06-28" version="1">MAAMPAKTGRAVDERFQVATPLRRLLNKVFPDHWSFLLGEIALFSFIVLLLTGVFLTFFFEPAMTEVIYNGSYAPLRGTPMSAAYASTLDISFDVRGGLIMRQMHHWSALLFMAAIVVHMLRIFFTGAFRKPRETNWIIGSLLFWVGFLAGFTGYSLPDDGLSGTGLRIASAIMLSIPVIGSWVTSSVFNGEFPGTIIISRFFIAHVLLIPGLLVALISVHLGLVFKQKHTQWPGPGRTNGNVVGERMFPRYAIKQGGFFMVVFGVIALMGGLFQINPVWLFGPYEAWVVSAASQPDWYVMFLDGSTRLMPDWEIFIPIGDGYVIPPLFWPTVVLPGILVMLSLFYPFMEARYLKDYRSHNLLQRPRDVPFRTALGMMAITFYVILTLTGANDVIADKFHISLNAMTWAGRIGLLVLPPVAYYITYRICLGLQQHDREVLAHGVETGIIRRLPDGRFVEVHQPLSSGGEHGELPYAGWVVPKKMNRLGALGPAIRGFFYPIEKPAEAPVSPGHPPVEPRAEREEISSGDSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2F6</accession>
    <name>F4F2F6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_14580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732695.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14580"/>
    <dbReference type="EnsemblBacteria" id="AEB44028">
        <property type="protein sequence ID" value="AEB44028"/>
        <property type="gene ID" value="VAB18032_14580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14580"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_13_2_11"/>
    <dbReference type="OMA" id="NWIDRVA"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="233"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="423" mass="44091" checksum="BBBCCF2F6CA3FA3C" modified="2011-06-28" version="1">MTEPLVLAGPAPPRRPRIPRLLRQTAFRRYWSAQTVSLFGDQVTMLAVPLLALLAVGAGPAEMGYLTAASLLPNLFLSLPAGAWVDRHPRRRRVMIAADLGRAGLLLAVPLLWWTGTLNLMLLCAVAFLIGCLSVFFEVAHSSLFAALVRRPDYVDANSLVNGSRAMSHVAGPSIGGLLVQVLTAPVALLSGVLTYLVSAVFLARTRVTEHTVTTGTALGMAAGVRFVARSEILRATLLGTTTLNLFNYMFAALFVLYVTTELGVSPGILGLVIGAGAVGGLLGAAVTGPVSRRIGIGPAVLVGFVAFPAPLVLVPLAMGPEPVVLALLFTAEFVSALGVMVLDIAVGSVQIAATPVAMLAVVSGFRRTVNHGIRPIGALVGGTLGAAIGVRPALWIASIGALLGLLWVVFSPLRGMRTLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2J8</accession>
    <name>F4F2J8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">aspS</name>
        <name evidence="10" type="ordered locus">VAB18032_14790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732737.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14790"/>
    <dbReference type="EnsemblBacteria" id="AEB44070">
        <property type="protein sequence ID" value="AEB44070"/>
        <property type="gene ID" value="VAB18032_14790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14790"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_11"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="135"/>
            <end position="563"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
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        <location>
            <begin position="563"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="591"/>
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        </location>
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        <location>
            <position position="168"/>
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        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
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        <location>
            <begin position="214"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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            <position position="223"/>
        </location>
        <ligand>
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        <location>
            <position position="448"/>
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        <ligand>
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        </ligand>
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        <location>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="489"/>
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        <ligand>
            <name>L-aspartate</name>
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        <location>
            <begin position="534"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
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    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="31"/>
        </location>
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        <location>
            <position position="76"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AEB44070.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="606" mass="66268" checksum="97F8118CFE4DC164" modified="2011-06-28" version="1">MIRTHDAGSLRATDAGTTVTLAGWVARRRDHGGVIFVDLRDGSGVVQVVFREEDAHALRNEYCVKVVGEVTRRPEGNENPELPTGEIEVTASELDVLSEAAPLPLPVDDQVVAGDDIRLKYRYLDLRRSGPAKAMRLRSRANQLARTVLHERDFLEIETPTLTRSTPEGARDFLVPVRLQPGSWYALPQSPQLFKQLLMVGGMERYYQIARCYRDEDFRADRQPEFTQLDIEMSFVTEDDVIDLGEAIVSALWSDLAGYEIPRPIPRITWHDAMARYGSDKPDLRYGVELTELTDYLRGTTFRVFAGAIDAGGYVGAVVMPGGASQTRKELDGWQDWAKARGAKGLAYVVLDAETGEARGPVAKNLSAEHLNGLADAVGAKPGDAIFFAASAETREAQELLGAARIEIAKRAGLIDESAWAFCWVVDAPMFERTSDESGAADGWTAVHHPFTSPNSEWVDRFEEAPDRALAYAYDIVCNGNEIGGGSIRIHRRDVQQRVFDLLGITPEEAQDKFGFLLEAFSYGPPPHGGIAFGWDRVCMLLAGADSIREVIAFPKTRGGFDPLTGAPTPITAQQRTEAGIDAKPKPTQAPHPGTAGPAAPVADPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Q0</accession>
    <name>F4F2Q0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733969.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21075"/>
    <dbReference type="EnsemblBacteria" id="AEB45315">
        <property type="protein sequence ID" value="AEB45315"/>
        <property type="gene ID" value="VAB18032_21075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21075"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049564_0_0_11"/>
    <dbReference type="OMA" id="FGIWGPN"/>
    <dbReference type="OrthoDB" id="1896788at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008910">
        <property type="entry name" value="TM_helix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05552">
        <property type="entry name" value="TM_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="386" mass="40615" checksum="F30C10DC74DAE6F2" modified="2011-06-28" version="1">MRDNFGDAVGETLRSILLFLPRAVAFVAILVAGWLIAKAVLKLADRLLERVGFDRAVERGGIRRALANSRYDASDIVARLAYYGVLLLTLYLAFGIWGPNPISDLIAGVIAWLPRAFVAIVIVVVAAAIASAVKDIISGALGGLSYGRLLATIASVFILGLGIIAALNQIGIATAVTTPVLIAVLATVGGILVVGVGGGLVRPMQSRWESWLSRAEQETRTITEHARAYSATRRDAQQRPAEPVAPAAGIVTESTSFAGPTTPTGPTTPAVDVPAEPTFTAPTASTSAGSFGDRLGYDDPEATQIVTAPGSNDDTTALPRRDDPEATQIVDTAGIDSDPTTTLPRQDDDPETTQVTTSAPEVPTQRTADDSESTIVLPRRDDEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F323</accession>
    <name>F4F323_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_03600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736434.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03600"/>
    <dbReference type="EnsemblBacteria" id="AEB47802">
        <property type="protein sequence ID" value="AEB47802"/>
        <property type="gene ID" value="VAB18032_03600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03600"/>
    <dbReference type="eggNOG" id="COG2215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058605_4_1_11"/>
    <dbReference type="OMA" id="HALEPGH"/>
    <dbReference type="OrthoDB" id="1515392at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="261" mass="27086" checksum="E3BA71BFD3B2FA6B" modified="2011-06-28" version="1">MNGLNDLDQRLLALFDNSTLFWLALVVAVGVGAAHAVAPGHGKSITAAYLVGTHGRYRDALRLGVIVAVMHTFSVLVLALVWTAFSGAASLGTTTITAGLQVLAGLVVIGVGAHLIRRHLRRRHAHAHDHHHGHAHDHSHDHHHHHHDETVDPWSRRGLVALGLSGGLLPSPSAFLILVSGLLTGRAVGAVVIVLAFGAGMALTLTGVGVLTIRGQALLAGQSRRWALLSSVSAWTPAIAGVAVCLGGCLYVAAAVSTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F353</accession>
    <name>F4F353_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEBP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736464.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03750"/>
    <dbReference type="EnsemblBacteria" id="AEB47832">
        <property type="protein sequence ID" value="AEB47832"/>
        <property type="gene ID" value="VAB18032_03750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03750"/>
    <dbReference type="eggNOG" id="COG1881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_2_1_11"/>
    <dbReference type="OMA" id="LRWEGFP"/>
    <dbReference type="OrthoDB" id="1150223at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="177" mass="18977" checksum="2F7BC553E5406307" modified="2011-06-28" version="1">MTLERPIAPDPYELLPTVASFTLTSQDVQNGEPMDAAHAHGSTGGGNVSPQLSWSGFPAETKGFAVTCFDPDAPTGSGFWHWVLVNLPADVTELPRGVADDDLRGGFTVRNDYGEQGFGGAAPPPGDRPHRYVFAVHALDVERLDVTPDATPAYVGFNLTFHTLARATIRPTYQVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3G9</accession>
    <name>F4F3G9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14825"/>
    <dbReference type="EnsemblBacteria" id="AEB44077">
        <property type="protein sequence ID" value="AEB44077"/>
        <property type="gene ID" value="VAB18032_14825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14825"/>
    <dbReference type="HOGENOM" id="CLU_1730648_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="16666" checksum="4F6914EDAEEA8E1D" modified="2011-06-28" version="1">MPARRPPAVSVHFRAALTLPRARRGRRRGRSQGLPLTRVRNRISDVPLVPTRRPRRVRQPPNRPAPARWTAPGQARRSPARLAARIRPVASPRLADPVRPVGLPRLADPVRLGGPSRLEAPQRMGDPLCLEGPLRPVGPVRPAARRSSVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3I6</accession>
    <name>F4F3I6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732761.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14910"/>
    <dbReference type="EnsemblBacteria" id="AEB44094">
        <property type="protein sequence ID" value="AEB44094"/>
        <property type="gene ID" value="VAB18032_14910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14910"/>
    <dbReference type="eggNOG" id="COG0510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673745_0_0_11"/>
    <dbReference type="OMA" id="WDWERFA"/>
    <dbReference type="OrthoDB" id="565681at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="414" mass="43939" checksum="89F53C82731D0DF9" modified="2011-06-28" version="1">MTGADDLRSREDGLGWVTRAVFGDQRITLVVDAPVPAGHTVVARYAVVPSVDRARFLLPLGSSRATAAALLAYNALRPVKVRAVRAALGVAARAGVVARAPFPVLSVAVPAALDPAEVLLAERLSTELGGGRAYAACGVRPPDPNHKPTLQLFDHAGTPRGYAKIGWNDATRALVTAEAAALREVAEVAGVAGHPATPRLLAETNWAGQAVALVEPLPTGVRGVPVDAPPELAALLAVARRGRPPATPRPLAGSSFLDRLTVAAQRAAETDPAGARAVAAVAELARRHGDVAVEFGHWHGDWVPWNLGRHAGELVAWDWEHSGPDVPVGFDLAHDAFQRSLVLRGEPAATAAEQVTQWLDRYGDRLGLDPARRRLVADAYLIEMWLRTWRLADAGAGWNPALHPALLDVIEKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3K5</accession>
    <name>F4F3K5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrD</name>
        <name evidence="13" type="ordered locus">VAB18032_15005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15005"/>
    <dbReference type="EnsemblBacteria" id="AEB44113">
        <property type="protein sequence ID" value="AEB44113"/>
        <property type="gene ID" value="VAB18032_15005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15005"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013640_2_0_11"/>
    <dbReference type="OMA" id="ERIKMGA"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="53"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="316"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB44113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="345" mass="36171" checksum="6FD193C0604E43F1" modified="2011-06-28" version="1">MFEQTVRRGLFRVGGGDAEAAHEWTLRRLSALSRTPGALAVLRARYAVAAPRTVFGVRFPNPVGLAAGMDKDGVALPAWPALGFGFVEVGTVTAYPQPGNPRPRLFRLPDSEAVINRMGFNNAGAEALAARLAALPRPLGVPLGISLGKSKVTPLDEAVADYQASYRALRGHGDYFAVNVSSPNTPGLRALQDRDHLDALLAALVGEKPVLVKIAPDLTEPAIAELLEVCLARGAAGVIATNTTLGRDGLAPGDRHRADEAGGLSGRPLTDRARQVVDFVHRETGGRLPIIGVGGIVHPDDAARMFDAGASLVQLYTGFIYRGPALPRAVARAAATAPRAATTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3L1</accession>
    <name>F4F3L1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ordered locus">VAB18032_15035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732784.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15035"/>
    <dbReference type="EnsemblBacteria" id="AEB44119">
        <property type="protein sequence ID" value="AEB44119"/>
        <property type="gene ID" value="VAB18032_15035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15035"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_3_11"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="OrthoDB" id="1346419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="185"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="408" mass="42788" checksum="EE34608C36FF4076" modified="2011-06-28" version="1">MNARIILGVGGGIAAYKACELLRLFTESGHQVRVVPTAAALRFVGAPTWAALSGQPVAEDVWSDVHEVPHVRLGQQADLVVVAPTTADLLAKAAQGIADDLLTNTLLTARCPVVLAPAMHTEMWEHPATVENVATLRRRGVRVIEPAVGRLTGADTGKGRLPDPAEIFAVARRTLARGVAAPADLTGRHVVVTAGGTREPLDPVRFLGNRSSGKQGYAFARAAVARGARVTLISANVSLPDPAGVDLIRVGTTAELRDATLKAAVEADAVVMAAAPADFRPATYASGKIKKTDDGVAPTIELVTNPDIAAELGQRRRPEQVLVVFAAETGDAEANGRAKLARKRADLIVINEVGPDKVFGADTNAATVIDVDGSVTRLAEQSKEDLADQVWDQVVVRLGGGSSLRVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3M3</accession>
    <name>F4F3M3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">VAB18032_15095</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732796.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15095"/>
    <dbReference type="EnsemblBacteria" id="AEB44131">
        <property type="protein sequence ID" value="AEB44131"/>
        <property type="gene ID" value="VAB18032_15095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15095"/>
    <dbReference type="eggNOG" id="COG0117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_1_0_11"/>
    <dbReference type="OMA" id="PYIILKW"/>
    <dbReference type="OrthoDB" id="1775351at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="284"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB44131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="353" mass="36032" checksum="10B21BF02FFB01E8" modified="2011-06-28" version="1">MASVSVDEAMRRAIELAARGLGTTSPNPVVGCVLLDADGEVVGEGFHAYAGGPHAEIVALAQAGHRAKGGTAVVTLEPCDHTGRTGPCSDALVQAQVARVVIAVPDPTPVAAGGAATLRAAGIRVDLGVRATEAENGNVAWLTAMRRGWPYVIWKYAATLDGRSAAADGTSMWITSEAARMDVHALRATVDAVIVGVGTVLADDPRLTVRNLRDGSLAIRQPLRVVVDSAGRTPLDAQIRDAAARTWIATAAEVGAGPDGGVDLPALLAALHAKGVRAVLLEGGPKLAGAFLAAGLVDRVVGYLAPRLLGAGPAALVDAGVTTIAEAIDLEITDVTQIGPDLRITALPRKREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3U2</accession>
    <name>F4F3U2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_21465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21465"/>
    <dbReference type="EnsemblBacteria" id="AEB45393">
        <property type="protein sequence ID" value="AEB45393"/>
        <property type="gene ID" value="VAB18032_21465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21465"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023846_0_0_11"/>
    <dbReference type="OMA" id="GVHVGTM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="257"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="278"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="736" mass="82514" checksum="C8CFDAF843466ABC" modified="2011-06-28" version="1">MLRMLDRADKEVMKLSRADKGAVYEFTHKFRNNPDNPGLQLKSLHGNSRLMSARINRDYRALLLHIAERDFLLVAVKHRSEVYDDLSRYAYRINRVTGGIEVIDLTPVGDSIVGRVVSADSSVAVPSVTDPAVADPSVADPQPTPKPIFDRYSDTELVELGVAEPLLPQIRDLTTEAELLELLDRAPQLTTDVLFALFDGKTYDEVRAQVTDPVRAEEPIDPEDFEAAVARPATQVTSDDEALQAMLVESFGRWQIFLHPTQRKLVERQYNGPARVGGGPGTGKTIVALHRVAYLARQLPPGVDKPILLTTFNRNLAADLRTRLMALGGEELVARVDIVNIDRLASRVVAEARAGGGRRTVSDNEVPQLWADFLIETGETGWEPEFLAAEWTQVILGQVLNSRIDYFKARRPNRGRSLNRMERDQIWRLTERFTTWLEGQGIWTWRQVAERAARLEMDRAAASSTESSGSLHRPRYRHVVVDEAQDLSAAHWKMLRAMVASGPDDMFLTGDTHQRIYDNHVTLGSLGINIRGRSSRLTLSYRTTRQILADALQIMTGEVYDDLDGGEEDLAGYRSLLRGERPSFRGAATWAQERDLIAEQVHAWGDPTDGSVAVCVPTREFAADVIARLEADGLPAVEIGPDGPKQPDGVHVGTMHRFKGLEYQRMIIAGVSDGLIPRQAISRYRDTDPKRYQRERQRDRSLLFVAATRPRDELVVLWHGTPSPFLTSRLVQRQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F492</accession>
    <name>F4F492_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736537.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04115"/>
    <dbReference type="EnsemblBacteria" id="AEB47905">
        <property type="protein sequence ID" value="AEB47905"/>
        <property type="gene ID" value="VAB18032_04115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04115"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_0_11"/>
    <dbReference type="OMA" id="GAWIQDP"/>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="29047" checksum="6125ECD13729B22A" modified="2011-06-28" version="1">MEALPRLVASDIDGTLLRDDATLSAHTAEVLARISARGTPVVLVTGRPIRWLKLVYDQLAEPVPAVCANGAVVYDPVNDEVLRADPLAPELLAEVARRLRAEVPGVSFAVEIADSRQMRHEAHYPMRWDADDTAIRVVTTPDELHSLPAVKLLVRAEEQQDPDRFTELVATALAGLAEATHSSRSGLVEISAAGVTKAAGLAWYCHRLGIEADEVLAFGDMPNDVPLLTWAGRAVAVANAHPAVREIADEVTSANSVDGVAAYLEKVFGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4B3</accession>
    <name>F4F4B3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04220"/>
    <dbReference type="EnsemblBacteria" id="AEB47926">
        <property type="protein sequence ID" value="AEB47926"/>
        <property type="gene ID" value="VAB18032_04220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04220"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_1_11"/>
    <dbReference type="OMA" id="RREPAWF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="64"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="27511" checksum="D56BA3546E805B68" modified="2011-06-28" version="1">MTEAGETADTLAAQVGVDPKTAARWASHGRIPRPQTRRRVAAVLGREVTELWPDVLKRREPAWFRRWVDIEREAVALRWFELTWVPGLLQTEAYARATLAGEKLTTDDVGRLVEARLQRQAILRRDNPPMLVVVLDELVLRRSAYGDRALMREQCEHLVACGTHPTTTIHVVPASVGMYPGLGGPFTLAELDDGSVLGHADSQAEAKIIDNPADVATLGRRWERIRGEALSRTQSLELIREAAASWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4C1</accession>
    <name>F4F4C1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moaC</name>
        <name evidence="7" type="ordered locus">VAB18032_04260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736566.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04260"/>
    <dbReference type="EnsemblBacteria" id="AEB47934">
        <property type="protein sequence ID" value="AEB47934"/>
        <property type="gene ID" value="VAB18032_04260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04260"/>
    <dbReference type="eggNOG" id="COG0315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074693_1_1_11"/>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="OrthoDB" id="1595361at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="17077" checksum="C906A70FD929F0EA" modified="2011-06-28" version="1">MTQPAELSHVDETGAARMVDVSAKEVTGRLAVAAGRLRTTAEVIELLRRDGLPKGDALAVGRLAGIMGAKRTPDLIPLCHPIALHGVTVDLSLTTDTVEITATARTADRTGVEMEALTAVAVAGLALVDMVKAVDPAASVEAVRVLRKEGGKTGLWQRPQDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4D4</accession>
    <name>F4F4D4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08870"/>
    <dbReference type="EnsemblBacteria" id="AEB42892">
        <property type="protein sequence ID" value="AEB42892"/>
        <property type="gene ID" value="VAB18032_08870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08870"/>
    <dbReference type="eggNOG" id="COG5485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2107986_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="115" mass="12960" checksum="7B1D633218F16BAE" modified="2011-06-28" version="1">MTTQEDLRNWYLRYVAALNAHEFDGMDEFINDQVLLNGRMGTRDDVLTVQRQDIDAVPDLHWEVKELLFDRNRIAVRAINTGTPVKKWLGVAPSGTSFESSSTPSMRSGTAGSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4D7</accession>
    <name>F4F4D7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08885"/>
    <dbReference type="EnsemblBacteria" id="AEB42895">
        <property type="protein sequence ID" value="AEB42895"/>
        <property type="gene ID" value="VAB18032_08885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08885"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_1_2_11"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="178" mass="18993" checksum="ACAFEE11441DE46B" modified="2011-06-28" version="1">MVTERAEDLCLELARLKAQAVVARLRPADDQRTLVLGCDSVLAFEGQILGKPADPDDATARWERMRGRSGVLHSGHCLVDVEAGRQAEAVASTVVHFADISDHEIATYVGTGEPLAVAGAFTIDGLGGPFVERIEGDPSTVIGLSLPLLRRLLAELDLRITDLWTKVAPGNQSVESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4F0</accession>
    <name>F4F4F0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-flanked domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731579.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08950"/>
    <dbReference type="EnsemblBacteria" id="AEB42908">
        <property type="protein sequence ID" value="AEB42908"/>
        <property type="gene ID" value="VAB18032_08950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08950"/>
    <dbReference type="eggNOG" id="COG3428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111473_0_0_11"/>
    <dbReference type="OMA" id="HGVIWGI"/>
    <dbReference type="OrthoDB" id="1750498at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="78"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="20443" checksum="04D2E3A5A5F5F4C3" modified="2011-06-28" version="1">MAFPEDVLTEDEHVVLHLRPHWKALIRPVAVLVLAIAAVVVGLVFLPSGGGGSITLAVIGGLAVLAVLVLGVWPYIVWRTTHYLFTNERVVLQHGVFSRERRDIPLSRVNDHSMNQQFVGRLLGYGTLTIESAGERGQSVLPDVPKVDRVQTKLYELVEAFHDKHSLGDGELREILAERDNKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4G1</accession>
    <name>F4F4G1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phoh family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_09005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731590.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09005"/>
    <dbReference type="EnsemblBacteria" id="AEB42919">
        <property type="protein sequence ID" value="AEB42919"/>
        <property type="gene ID" value="VAB18032_09005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09005"/>
    <dbReference type="eggNOG" id="COG1875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022283_2_1_11"/>
    <dbReference type="OMA" id="KMSPWAQ"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="45"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="471" mass="51057" checksum="6FB9AE9A32D9AD7A" modified="2011-06-28" version="1">MTTRRTTAGADQSPAATATTRRTTRSRRTAATASADTREPRPAGQSFVLDTSVLLSDPAAFHRFAEHEVVLPLVVISELEGKRHHPELGWFARKSLRMLDELRVRHGRLDRPVPANDDGGTLRVELNHTDDGVLPPGFRNESNDARILSVALNLAAEGRQVTLVSKDMPLRVKAASVGLRADEYRHGQASDPTWTGMAELDLAEEDIGRLYGGESIDVDAAAGLPCHTGLVLHSTRGSALGRVLPDKTVRLVRGDREAFGVHGRSAEQRIALDLLLDESIGIVSLGGRAGTGKSALALCAGLEAVMERRRHKKVIVFRPLYAVGGQELGYLPGSESEKMSPWAQAVFDTLGAVVHENVLEEVTSRGLLEVLPLTHIRGRSLHDAFVIVDEAQSLERGVLLTVLSRIGQGSRVVLTHDVAQRDNLRVGRHDGVTAVIEALKGHQLFAHVTLSRSERSPIAAMVTDLLEDIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4H3</accession>
    <name>F4F4H3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphoesterase pa-phosphatase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_09065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09065"/>
    <dbReference type="EnsemblBacteria" id="AEB42931">
        <property type="protein sequence ID" value="AEB42931"/>
        <property type="gene ID" value="VAB18032_09065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09065"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052628_1_0_11"/>
    <dbReference type="OMA" id="CMFRSAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="148"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="359" mass="40528" checksum="F07A6753B1017328" modified="2011-06-28" version="1">MTNQPYDTTEAEAADTSTGHGAQPRRPGRRITLTRSRAVAAWAVLLVAACLAFGLPTDPGYAFLWLWALAVAWRIDQPVRSHLAFARDWLPVIALLTVYNLSRGFADNIREPHVTELINADLRMFGWLTDGKVPTVWLQQELYDPSRVQWWEVLVSYVYFSHFVVALGVAIALWLTARPRWAAFMRRWFVLSLAGLITYFLYPAAPPWWAAVHGYLEPVERLSLRGGAEFGMHGAFSLIRLGQLASNPVAAIPSLHTAFALFVVLFFVGRIRKRYVAILLLYPLAMTFTLVYSGEHYVIDVLIGWAYVLGTFAIVSFGERWWRRRRLRQRAATPTPTPDDGDAAADQREHSEPKQSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Y7</accession>
    <name>F4F4Y7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpA</name>
        <name evidence="10" type="ordered locus">VAB18032_21880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734129.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21880"/>
    <dbReference type="EnsemblBacteria" id="AEB45476">
        <property type="protein sequence ID" value="AEB45476"/>
        <property type="gene ID" value="VAB18032_21880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21880"/>
    <dbReference type="eggNOG" id="COG2060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018614_3_0_11"/>
    <dbReference type="OMA" id="RQGWAIL"/>
    <dbReference type="OrthoDB" id="296671at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="551" mass="57587" checksum="61D97993266CEC33" modified="2011-06-28" version="1">MTGTSTGVLFVLSLVVALAVVHRPLGDYLYRVVCAERHSRVERGIYRLIGVNPAAEQSWGVYARAVLAFSAVSVLFLYAFLRLQNHLWLSLGFDPVVAHGAWNTAVSFVTNTNWQWYSGESTMGHLVQMAGLAVQNFVSAAVGIAVAVALVRGFARSRAGQLGNFWVDLTRITLRVLLPLSVLAALVLMIGGAVQNLSAGTEITTLTGGGQRITGGPVASQEAIKNLGTNGGGFYNVNSAHPFENPTAWTNWWEIFLLLVIPFSLPRVFGRMVGQVRQGYAIVAVMATLALASVALTTAFEVSGHGTVPQAIGAALEGKEVRFDVSNSATFAAATTLTSTGSVNSFHDSYTALGGGVLLVNMMLGEVAPGGVGAGLYGLLILAVITVFVAGLMVGRTPEYVGKKIGPREIKLASLYFLIPPALVLIGTAAAFATGNHLTALNAGPHGLSEVLYAFTSASNNNGSAFAGLTVNTPWWNTALGLCMLVGRFAPIILVLALAGALARQQPTPASPGTLPTHRPLFVGMVVGVTVVLVALTFLPALALGPLAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5I9</accession>
    <name>F4F5I9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731692.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09515"/>
    <dbReference type="EnsemblBacteria" id="AEB43021">
        <property type="protein sequence ID" value="AEB43021"/>
        <property type="gene ID" value="VAB18032_09515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09515"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_11"/>
    <dbReference type="OMA" id="YHGVNIA"/>
    <dbReference type="OrthoDB" id="478143at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="448" mass="48953" checksum="0E4E045D9B109416" modified="2011-06-28" version="1">MANATDHLWMHFTRMASYSAGEVPTIVRGEGAYVWDAQGRRYLDGLAGLFVVNAGHGRTELAEAAAKQAGELAYFPLWSYAHPTAVELAERISSLTPGDLNRVFFTTGGSEAVEAAWKLARAYFKRVGKPTKHKVVSRYIAYHGTSMGALSITGLPGIKTDFEPLVPGGIKVPNTNFYRAPEHGDDPVAFGRWAADEIGRAIEREGPDTVAAVFLEPVQNSGGCFPPPPGYFERVREICDAYDVLLVSDEVICSWGRLGEYFGAVRYGYQPDIITTAKGITSGYAPLGAMIASDRLMEPFLTETGMFAHGVTFGGHPVSCAVALANLEVFAREDLVGHVRANEGAFRSTLEKLHDLPIVGDVRGDGYFYGIELVKDKTTRETFDEAESERLLRGFLSTALFDAGLYCRADDRGDPVVQLAPPLIAGQQQFDEIEQILRTVLTEAWSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5K5</accession>
    <name>F4F5K5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ordered locus">VAB18032_09595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731708.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09595"/>
    <dbReference type="EnsemblBacteria" id="AEB43037">
        <property type="protein sequence ID" value="AEB43037"/>
        <property type="gene ID" value="VAB18032_09595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09595"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_0_0_11"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="167"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="388" mass="41114" checksum="868B27B093286B07" modified="2011-06-28" version="1">MSERHSGGARRDGGGRPQVIGVLFGGPSAEHEVSCASALGVARALVGGGYQVVALGVTRQGRLRLVPEETLAAHIDGTAAARAIDDRLSVTGSAVELRAGERPGTALVTGAESPGEVHAVLDVVFPVLHGPYGEDGVVQGLLESLGVPYVGCGILASAVGMDKVAMKRALRAEGVPITPHVWFDEHTYRTTEDVEKLVVGLRRPLFVKPARMGSSIGISRVTEDDDLAAAVEEALRHDNLVVVEQGVTGRELECGVLGGTRPEASTVGEVRVTGGWFDYQQKYFGDADPMVVPAVLPDEVTERIRDLSLRAFAAIGGWGLARVDFLYDESAGELYVNELNTMPGFTAHSMYPKVWAAAGVGYQQIVDRLVALAVERRASRPTSQEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5U2</accession>
    <name>F4F5U2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_15975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15975"/>
    <dbReference type="EnsemblBacteria" id="AEB44305">
        <property type="protein sequence ID" value="AEB44305"/>
        <property type="gene ID" value="VAB18032_15975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15975"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_61_2_11"/>
    <dbReference type="OMA" id="MGTSEFM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="40896" checksum="5779EE4AA1E70EFA" modified="2011-06-28" version="1">MPFSFSLTSELVMPLPLYLLAVAVFAMGTSEFMLAGLVPDIATNLNVSVGAAGLLTSAFAAGMIVGAPLMAALARRWPARASLLGFVLVFAVTHVVGALTTSFTILLVTRVLAALANAGFLAVALTTAATLVATDQKGRALAVLLAGTTVATIVGVPGGAVLGTLISWRATFWAIALLCLPAAVGVIKGIPARIDTTSQGTAPASSLRREIAQLAMPRLLLVMLLGALVNAATFATFTFLAPIVTDTAGLRGLWVSVALVIFGVGSFTGVTIAGRLSDQRPHIVIAIGGPLLLLGWVALAALATQPVALLLLVFVQGTLSFAVGSTLITRVLYEAAAAPTMGGSYATAALNIGAAGGPVVAAITLGADAGDLGPVWVSALLVAIALLIALPLRRVVTPRAGQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6A2</accession>
    <name>F4F6A2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_09650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731719.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09650"/>
    <dbReference type="EnsemblBacteria" id="AEB43048">
        <property type="protein sequence ID" value="AEB43048"/>
        <property type="gene ID" value="VAB18032_09650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09650"/>
    <dbReference type="eggNOG" id="ENOG5031MDN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705846_0_0_11"/>
    <dbReference type="OMA" id="GSMIMWF"/>
    <dbReference type="OrthoDB" id="2011608at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312722" evidence="3">
        <location>
            <begin position="31"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="391" mass="39473" checksum="94C9B02AFB0BF4F3" modified="2011-06-28" version="1">MSVGRRAARLATVCVFLGGLVMLGGAPAHADEDRVRVRSAGSFTAGRAAQDVRLEVRKRTDGCVRVRGALGLSLPGVRPEQVTVQAEVDRRWVSVPVSGTDGLVTTAPVAPARDELCKRKGTVIRYRVAFGADAPGGRLVVTGEAVTARGVLLGRAVAESQVNGGRVAPTPSRSPSPTPTLDEVVDTPPAPTATVALAADTPGEMSQAANQSGGISSVMYVGIAMVAAGALLIGLLVFRSRRDRRRRGEQVDVPLPGNPAGTTYRSTRSPAPTPPGPQVLPPPGPQAVPPAAPGQVYGTGRPPTPRVYGGTPTARPAGGLYGARPTGAGDQSPTETAPGVSSSAPVPPVSGSAAVPPVSAPPAQGGSPGWQDPPPPAVPGDDPRYGGGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6A8</accession>
    <name>F4F6A8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ordered locus">VAB18032_09680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731725.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09680"/>
    <dbReference type="EnsemblBacteria" id="AEB43054">
        <property type="protein sequence ID" value="AEB43054"/>
        <property type="gene ID" value="VAB18032_09680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09680"/>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_11"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="OrthoDB" id="522981at2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="257"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="286"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="365"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="499" mass="54027" checksum="9BC247C98D0DFD00" modified="2011-06-28" version="1">MTSTLPASASGTSPNARPRTLAEGDFRVADLSLAEFGRKEIRLAEHEMPGLMAIRREFAEAQPLAGARITGSLHMTIQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAIVVGPDGTPDAPAGVPVYAWKGETLQEYWWCTEQVLDWPDGQGPNMILDDGGDATLLVHKGVEFEKAGVVPPVESADSEEYAVILGLLHRSLAEDGQRWTRIAATIKGVTEETTTGVHRLYEMHRAGTLLFPAINVNDSVTKSKFDNKYGCRHSLIDGINRATDVLIGGKMAVVLGYGDVGKGCAESLRGQGARVVVTEVDPICALQAAMDGYQVATLDDVVEIADIFITATGCFDVITNEHMARMKHQAIVGNIGHFDNEIDMAGLAKRSDVTRENIKPQVDLWKFDDGHAIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELFTKTEEYPIGVYVLPKHLDEKVARLHLAALGAKLSTLTKEQAAYLGVAVEGPFKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6L9</accession>
    <name>F4F6L9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated Cse4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733007.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16205"/>
    <dbReference type="EnsemblBacteria" id="AEB44347">
        <property type="protein sequence ID" value="AEB44347"/>
        <property type="gene ID" value="VAB18032_16205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16205"/>
    <dbReference type="eggNOG" id="COG1857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044824_0_0_11"/>
    <dbReference type="OMA" id="PTGKQNT"/>
    <dbReference type="OrthoDB" id="922733at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010148">
        <property type="entry name" value="CRISPR-assoc_prot_CT1975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09344">
        <property type="entry name" value="Cas_CT1975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01869">
        <property type="entry name" value="casC_Cse4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="374" mass="39989" checksum="238A50619079D458" modified="2011-06-28" version="1">MSRTIIDVYALQTVPPSNLNRDDTGSPKTAVYGGVRRARVSSQAWKRAIRLAFVDLLDRSQLGERTKRVGESLAARIRALDPSMSEEAASTLAADTFVAGGLAKVDKKKGETKDVESGYLLFLSHRQLDNLAAAALEAARAGGTLDKARFKALVASEHSVDIAMFGRMVADMTDINVDAACQVSHAISVHAVDNEFDYFTAVDDRKADAAETGAGMIGTIEFNSSTLYRYATIDVDALYRTLGDAAATRAAVEAFLSAFTRSMPTGKQNTFAHRTLPDAVLVRLRDTQPINLVGAFETPIRETHAAGRIELAAEALAKHTVAVESAYGERPIGSWVTQVGERTAVLTDLGKAVTFSELVAGVGEQVTVTLGQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6M2</accession>
    <name>F4F6M2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ordered locus">VAB18032_16220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733010.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16220"/>
    <dbReference type="EnsemblBacteria" id="AEB44350">
        <property type="protein sequence ID" value="AEB44350"/>
        <property type="gene ID" value="VAB18032_16220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16220"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077904_0_0_11"/>
    <dbReference type="OMA" id="IWVGEAG"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09719">
        <property type="entry name" value="Cas1_I-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033641">
        <property type="entry name" value="Cas1_I-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019851">
        <property type="entry name" value="CRISPR-assoc_Cas1_ECOLI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03638">
        <property type="entry name" value="cas1_ECOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="322" mass="35592" checksum="1CE00BBB66DCBF2F" modified="2011-06-28" version="1">MKIPGVPPAELADLNRVQDRLSFIYLERCVIHRDSNAITTTDDKGIIHIPAATVGVLLLGPGTSITQQAMMLLADNGATVVWVGEHGVRYYAHGRPLARSSRLLVAQATAVTHRDRRLQVAREMYRMRFPGEDTTALTMQQLRGKEGARVRRSYREHAKRTGVNWNNREYNPDDFTSSDPVNQALSAAHACLYGVVHAVIVAVGTSPGLGFVHTGHDRSFIYDIADLYKAEYTIPVAFDVAASGSTDIGSDTRRAVRDRIHDGALLDRCVRDIRSLLLSPGPTGPIDEEWLDGEAENDTVRLWDESGYEFTSGRNYGGEVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6M9</accession>
    <name>F4F6M9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_16255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733017.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16255"/>
    <dbReference type="EnsemblBacteria" id="AEB44357">
        <property type="protein sequence ID" value="AEB44357"/>
        <property type="gene ID" value="VAB18032_16255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16255"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_11"/>
    <dbReference type="OMA" id="ISRPEYV"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="94"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="317" mass="34936" checksum="38E70F4B8304879C" modified="2011-06-28" version="1">MSSTTVAKPLARRASRGGSRRRKWTTERIIFTTLNTTFLLALAAVMVYPLLNTLAISLNDGMDAVRGGIGIWPRDFSLQNYNVVFNMHTIYQAFFMSVLKTVVVVATNLLFTSMLAYALSRTEFIFRRPITVIFVLTMYFDAGLIPNYLLIKDLGMLNTFQAYWVPTIISAFNLIILRTYIKSIPEEIIESARMDGAGEFRTWWQIVMPLCKPALAVVGLFVAVGSWNAWLDTLLYASGNPALTTLQYELQKLLSSSMNAGVNSVAATGAASSGGQVTTPIALRSAITMVAAVPILFVYPFLQKHFVSGLMIGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6U6</accession>
    <name>F4F6U6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ordered locus">VAB18032_22605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734273.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22605"/>
    <dbReference type="EnsemblBacteria" id="AEB45621">
        <property type="protein sequence ID" value="AEB45621"/>
        <property type="gene ID" value="VAB18032_22605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22605"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_11"/>
    <dbReference type="OMA" id="PESGWHE"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="265"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="416"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="505" mass="55024" checksum="164CF4AE188EDA12" modified="2011-06-28" version="1">MADFVGAVDQGTTSTRFMIFDHGGNEVGRHQLEHQQILPRAGWVEHNPLEIWERTQTVVRTALNTHSLAASDLVALGVTNQRETTVVWNRRTGRPYYNAIVWQDTRTDRIAAALDRDGRGEIIRRKAGLPPATYFSGGKIQWILENVDGVRAAAERGEAIFGNTDTWLLWHLTGGTDGGVHLTDPTNASRTMLMNLETLDWDDELLSFFDIPRAMLPRIVASSDPHAYGTTASGGPFAGTVRITGDLGDQQAATVGQVCFAPGEAKNTYGTGNFMLLNTGTEIVRSESGLLTTVCYQFAGEQPVYALEGSIAVTGSAVQWLRDQLKIIRTAAQSEDLARQVDDNGGVYFVPAFSGLFAPHWRADARGAIVGLSRYNTDAHLARAALEAICYQSRDVAEAMAQDSGVAVECLKVDGGVTVNELCMQLQADILGVPVSRPVVAETTALGAAYAAGLAVGFWKDTDELRDNWNESRRWHPSWSAQQRAAGYAGWQKAVGRTLDWVDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F701</accession>
    <name>F4F701_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735514.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28971"/>
    <dbReference type="EnsemblBacteria" id="AEB46865">
        <property type="protein sequence ID" value="AEB46865"/>
        <property type="gene ID" value="VAB18032_28971"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28971"/>
    <dbReference type="eggNOG" id="ENOG50336ZI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114123_1_1_11"/>
    <dbReference type="OMA" id="WHHGWET"/>
    <dbReference type="OrthoDB" id="1735593at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="154" mass="16261" checksum="745ABEACCDCB2125" modified="2011-06-28" version="1">MFADPTGTRAATFAAVFVALYVAHQVADHWVQTQHQADCKGRPGWAGRIACATHVTTYTLTAGLALVFLIAGTGLRLDPAGVAVGLTISAVTHYIADRRTPLQRIAAALGSARFYALGAPRPGRDDNPSLGTGAYALDQSWHIAWLFIAALFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F720</accession>
    <name>F4F720_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735533.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29066"/>
    <dbReference type="EnsemblBacteria" id="AEB46884">
        <property type="protein sequence ID" value="AEB46884"/>
        <property type="gene ID" value="VAB18032_29066"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29066"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_24_2_11"/>
    <dbReference type="OMA" id="FEANERY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_7C" evidence="3">
        <location>
            <begin position="180"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="414" mass="46388" checksum="B6AB68BFCC028CDA" modified="2011-06-28" version="1">MIDSTTTPHASVIIPTYNRADLLRLMLEQLTRQTQPLSDFEVIVSDDGSADDTADVVASFSERLRLKYCFQEDLGDRVSLARNRGAAIAEAEILIFLDGGGMLAPDLVERHISAHVGAPRRSVLGYGWGYDPRYPALEGLDRDLATMRPEEVLAKYRDLPAFRDVRHDALAAYDFELEAMPLPWQLFFALNVSMRAEDFHAVGGFDESMTGWGGEDLEMGFKLLRAGVAPHFDKDNWIIEWPHERDMTKRWPEMVANTFKFLRKYPEPVIEIGYVLCVANEYWRWEQCWLDLERWSQQVAEVDVAAELAQAATRIGPGERIAVFGAGGVLPPQLPPSFVADFDAALVRQATADTPHTPLHALGVRTLLEDQSVDTVLITSRLAGLWDTWRGHVLAEAQRIGRKVELLDPGMTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F756</accession>
    <name>F4F756_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tspo and mbr like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_29246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735568.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29246"/>
    <dbReference type="EnsemblBacteria" id="AEB46920">
        <property type="protein sequence ID" value="AEB46920"/>
        <property type="gene ID" value="VAB18032_29246"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29246"/>
    <dbReference type="eggNOG" id="COG3476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091805_2_1_11"/>
    <dbReference type="OMA" id="GLNLIWM"/>
    <dbReference type="OrthoDB" id="1679387at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="166" mass="18180" checksum="F4B95690F679AA2D" modified="2011-06-28" version="1">MRMTTARTRQPTRGTRQWWALAGFAVAVFAAAALGSLAVTGTSAEYASLEQPGWAPPSWLFGPVWTVLYAMIAVAGWLVWRRVGFGPALIAWVVQLVLNAAWTPLFFGAGQYGLAFAEIVVMWLAIGVTVLLFRRVSTLATALLLPYWAWVTFAAALNYSIWQLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7N7</accession>
    <name>F4F7N7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_22870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22870"/>
    <dbReference type="EnsemblBacteria" id="AEB45674">
        <property type="protein sequence ID" value="AEB45674"/>
        <property type="gene ID" value="VAB18032_22870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22870"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037123_1_0_11"/>
    <dbReference type="OMA" id="ITWVFGG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="64"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB45674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="383" mass="40218" checksum="88F8D97DD22839EB" modified="2011-06-28" version="1">MEQSRQSRPGRRPGLQVGRIFGVPLYLNASILLLAVLIIVLYGELAGQRLALSPTLGYLVGAGFVVSLLGSVLAHELGHALTARHFGIGVRGITLELLGGYTEMDRDAPSPRVDLLVSLAGPAVSALLGVAAVAATVALPDRTVAHQLAFQLAVSNVIVAVFNSLPGLPLDGGRALRAVIWAVTRDRHRATEVAGWVGRVLAVATVALVGLLYAADLLSLLALPLTALVALTIWHGAGQSIRLARIGRRLPLIDLARLARPVFAVPTATPLAEAQRRADESAPDRPVALLVTDAADRPVAVVDPAAAAAVPPHRRPWLAVDAVARAVADLPRMSVATDGERVLETVQAHPGAQYLVTAGEDVVGILHIADLAHLLEPHRKMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Q1</accession>
    <name>F4F7Q1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, gntr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734340.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22940"/>
    <dbReference type="EnsemblBacteria" id="AEB45688">
        <property type="protein sequence ID" value="AEB45688"/>
        <property type="gene ID" value="VAB18032_22940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22940"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_0_11"/>
    <dbReference type="OMA" id="APKWREL"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="263" mass="28949" checksum="5D2154438C8C9BDA" modified="2011-06-28" version="1">MQINPGAAEFPHRQIAAQLKSQIRRGDWGPGERLPSIPAIAEMFGVAKQTVQRAVDQLRVEGVLITKPGSGTYVRGTRRRLNRLSRGRYGGFRGYHTDLAARYRQQLVSVGRSPAPPEVADAFGVPDGTELLCRRHLVRTEDSPVEVGASWFLPADTAGTTLERAEAFGRPLYQEAEEATGRRYATATDTITARQPSREEAETLQIRPDTPVLHLLHVAYDAHRKPIEVAQATWPGPVTTLTEEYKIPAPTPDPHPDPGLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Y1</accession>
    <name>F4F7Y1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735604.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29426"/>
    <dbReference type="EnsemblBacteria" id="AEB46956">
        <property type="protein sequence ID" value="AEB46956"/>
        <property type="gene ID" value="VAB18032_29426"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29426"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_2_11"/>
    <dbReference type="OMA" id="IHHICYE"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="160" mass="17159" checksum="D424AEB15137E6D3" modified="2011-06-28" version="1">MPENSPVEPAADYVTDIGLRRIDHVGIAVADLDAAIDFYTRTFGMRCVHTETNTEQGVREAMLAVGPTTEGGCLQLLAPLTPESTIAKFLDRNGPGVQQVAYTVTDVDAACAALRERGLRLLYETPRRGTAGSRINFIHPKDAGGVLVELVEPAPHSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F814</accession>
    <name>F4F814_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="15" type="ordered locus">VAB18032_29591</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735637.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29591"/>
    <dbReference type="EnsemblBacteria" id="AEB46989">
        <property type="protein sequence ID" value="AEB46989"/>
        <property type="gene ID" value="VAB18032_29591"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29591"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_11"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="14">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="12">
        <location>
            <begin position="152"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="13">
        <location>
            <begin position="382"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB46989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="548" mass="59624" checksum="B9534A35818B6DAA" modified="2011-06-28" version="1">MAELTISTEEIRGALERYVSSYSPDVSREEVGTVADTGDGIAHVEGLPSTMTNELLEFEDGTLGVALNLDVREIGVVVLGDYSGLEEGQRVKRTGRVLSVPVGDAFLGRVVNALGQPIDGLGEIADEGYRELELQAPNVMARQSVFEPMQTGIKAIDAMTPIGRGQRQLIIGDRKTGKTTVALDTILNQRENWATGDPKKQVRCIYVAIGQKASTIASIKGQLEEAGAMEYTTIVASPASDPAGFKYLAPYTGSSIGQHWMYGGKHVLIVFDDLSKQAEAYRAVSLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDEMGGGSMTGLPIIETKANDISAFIPTNVISITDGQIFLETDLFNQGVRPAINVGTSVSRVGGAAQMKPMKKVSGSLRLNLAQFRELEAFAAFASDLDKASRAQLDRGARLVELLKQPNYSPYPVQDEVVSVWAGTEGKLDDIPVGDVRRFETQFLEYLRRKHNATLQAIADNKWDDEIIAALDAAVTEFKKGFLGREDERTVNEAPAEPLEGESEHETVTRYSGGAPAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4F834</accession>
    <name>F4F834_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29691"/>
    <dbReference type="EnsemblBacteria" id="AEB47009">
        <property type="protein sequence ID" value="AEB47009"/>
        <property type="gene ID" value="VAB18032_29691"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29691"/>
    <dbReference type="HOGENOM" id="CLU_2940552_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="60" mass="6264" checksum="D492E3ACDD175FAC" modified="2011-06-28" version="1">MGRGEGAGSRLAAGVHPALLDGDEVYRDLVTSLRIGTAPEIDGRIGSGTLLVPHDRLPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F891</accession>
    <name>F4F891_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ordered locus">VAB18032_10670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10670"/>
    <dbReference type="EnsemblBacteria" id="AEB43252">
        <property type="protein sequence ID" value="AEB43252"/>
        <property type="gene ID" value="VAB18032_10670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10670"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_1_1_11"/>
    <dbReference type="OMA" id="CHEHQAT"/>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="16598" checksum="9077E87A90E64B23" modified="2011-06-28" version="1">MVPEHGSLAVYPGTFDPFTPGHLDLLARARVMFDQIIVLLAVNADKRPTAEATTRAVQVREALPSAWGNVEVDTWTGLTTAYCLRRGATVIVRGLRTAADFHHEYQLAAMNETLGIQTVWLPARPELAATSSTTARAYRAALSDRPPLNAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8S3</accession>
    <name>F4F8S3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_23590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734468.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23590"/>
    <dbReference type="EnsemblBacteria" id="AEB45816">
        <property type="protein sequence ID" value="AEB45816"/>
        <property type="gene ID" value="VAB18032_23590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23590"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_11"/>
    <dbReference type="OMA" id="GHCLPID"/>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="320"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="420" mass="46422" checksum="3EAA2D478655AF9C" modified="2011-06-28" version="1">MSVEKLVVVGQGYVGLPLAMRAVEAGFDVVGLDVDTDRVKRLASGESFVADIPADRLGRATATGRYRPSSEYADAKDFDFCVITVPTPLRDGTPDLSFVEEAGTAIAPYLRPGCTVILESTTYPGTTEELLRPLLESASGLRSPGDFHLGYSPERIDPGNRTWRLENTPKVVSGMDPAALDRVDGFYRRLVERTVPVDSTQVAELTKLIENTFRQVNIALVNELTMLSHQLDIDVWQAIEAAETKPFGFMPFKPGPGVGGHCLPIDPCYLSWQVKRRLGRQFRFIELANDINHEMPEHVAQRVMAGLNRSGKAISSARLLVLGLAYKPNTGDMRDSPAVDVTRRLREFGAEVRAVEPYAAANHLPDGVLTVDLSEREIREADCVVVITDHDVFDYALVERHARYVFDARNRCAGPNVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8T1</accession>
    <name>F4F8T1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">VAB18032_29701</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735659.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29701"/>
    <dbReference type="EnsemblBacteria" id="AEB47011">
        <property type="protein sequence ID" value="AEB47011"/>
        <property type="gene ID" value="VAB18032_29701"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29701"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_0_11"/>
    <dbReference type="OMA" id="LMFYGPG"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="352"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AEB47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="433" mass="44264" checksum="A87573313E3EDCBA" modified="2011-06-28" version="1">MRLALLGCGTVGAEVVRLLHEQSADLAARIGAPLEIAGIAVRRIGRDRGELPVDPALFTTDALGLIKRDDVDVVVEVVGGIEPARSWLVEALRAGKSVVTANKALLAEDGGALHDAAVEGGGDLYYEASVAGAIPLLRPLRESLHGDRITQVTGIVNGTTNFILSAMHATGAGFAEALEEATALGYAEADPTADVEGFDAAAKAAILASLAFHTRVGAADVHREGITEVTAADVASAKAMGCTIKLLCIAARSTDAQGQESVNVRVHPALIPLTHPLASVGDAFNAVFVEADAAGQLMFYGRGAGGAPTASAVLGDVVAVSRNRLAGVRSASESSYAALPVRPMGEALTRYHISLDVADRPGVLEAVAGVFARHEVSLATVRQGPAGGGNGDAVLVIVTHVAPDAALAATVDELRGLEIVRSVTSVLRVEGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F900</accession>
    <name>F4F900_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30046"/>
    <dbReference type="EnsemblBacteria" id="AEB47080">
        <property type="protein sequence ID" value="AEB47080"/>
        <property type="gene ID" value="VAB18032_30046"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30046"/>
    <dbReference type="eggNOG" id="COG3677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190603_1_0_11"/>
    <dbReference type="OMA" id="RAAPFYC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="53" mass="5904" checksum="D1D82025DE3E55E5" modified="2011-06-28" version="1">MSSETRAAPLYCPYCGEEDLRPSETGHGAWECHGCARVFTVRFTGLLSRAVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F925</accession>
    <name>F4F925_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbaK/prolyl-tRNA synthetase associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730727.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04635"/>
    <dbReference type="EnsemblBacteria" id="AEB42053">
        <property type="protein sequence ID" value="AEB42053"/>
        <property type="gene ID" value="VAB18032_04635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04635"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104555_0_0_11"/>
    <dbReference type="OMA" id="ETGMEYG"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="47"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="18810" checksum="2885C863797DE9F3" modified="2011-06-28" version="1">MGTLKTEPARTRPDLLAAPVAAALAAWPTDAPVEVDSVLVAPIDADLADTAEFCAAYEVGLDESANCVVVAGKREGVIRYAACLVLATTRADVNGVARRALDVRKASFAPMTDAVELTGMEYGGITPIGLPAQWPILIDARVVATPYVIVGSGVRHSKIALPGAALAALPNARVVEDLAKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9F2</accession>
    <name>F4F9F2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein LacI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_11140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11140"/>
    <dbReference type="EnsemblBacteria" id="AEB43346">
        <property type="protein sequence ID" value="AEB43346"/>
        <property type="gene ID" value="VAB18032_11140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11140"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="FFMELIS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="34076" checksum="7B495AC33D0567F7" modified="2011-06-28" version="1">MSYALNGQPGVSEATRQRILAIAAEIGFSPSSAARALSGATARAIGLILARPAQTLGIEPFFMELISGVEAELSARSYALTLQVVADADAEIAVYRRWWGERRVDGVLVCDLRTDDQRVPVLEELRLPAVVIGGPTGTGRLASVWSNDAAALVETVEYLYALGHRRVARVAGLPDLLHTTIRTQAFTEVCQRLGLAEAVVASTDYTGEEGARATRRLLSSRIRPTAVIYDNDVMAIAGLSVAQEMGLAVPTDLSIVAWDDSPLCRLVHPPLTAVGRDIPAYGAHAARQLLQLIEGAPATDLEDEQAHLTPRGSTGPPGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9F6</accession>
    <name>F4F9F6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_11160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11160"/>
    <dbReference type="EnsemblBacteria" id="AEB43350">
        <property type="protein sequence ID" value="AEB43350"/>
        <property type="gene ID" value="VAB18032_11160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11160"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_3_2_11"/>
    <dbReference type="OMA" id="KRQWKGP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="214"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="849" mass="94146" checksum="D6B4D3C974A9599C" modified="2011-06-28" version="1">MSDARGTGPLRQALHDGWTLRAMSGPQVPPEVDGVTVPATVPGCVHTDLLAAGLIPDPYLDDNETALAWIGHTDWAYETTFDRPSGSHQRLDLVCAGLDTVATVAVNGVEVGRTENMHRGYRFDVTSLLQPRNNTLAVRFDSAYRYAHAHRDRLGDRPNAYPEPFQFIRKMACNFGWDWGPTLVTAGIWQEVGLHGWSVARLATVRPLVTLDGVDGRVAVQVEVDRLADLPLTVRAQVAGVTAETTVAAGQRSATLTLDVPRPALWWPRGHGDQPRHDLDVTLHGPDGATLDAWHRRIGFRSVRLDTTPDAHGAPFTLHVNGVPVFVRGVNWIPDDVFPTRVTRERLAHRFDQAVDANINLLRVWGGGRYESDDFYDLADERGLLVQQDFLFACAAYPEEEPYAGEVAAEAAEQVTRLAAYPSLVLWTGNNENIWGWHDWGWQEQLAGRTWGRGYYLDLLPRIVAELDPTRPYWPGSPWSGSEQTHPNDPAYGTTHIWDVWNTDDYVKYRDYLPRFVAEFGYQGPPAYATLRRALSDEPLAPDSPGMAHHQKATDGDAKLRRGLDAHLPAPRDFDDWHYFTQLNQARAIQLGVEHFRSHRGRCMGTIVWQLNDCWPVTSWSAIDGDGRRKPLWYALRRAYADRLLTVQPRDGGQSGTDGRSGDGFRAHAGGLVLVAVNDGGRPWRASVTISRLTVAGDPQAKTTLELDVPAYDTVNLALPAELTRPDEARRELLIADAGDPVGRALWFFAEDREIDYPPAEYDATVEPTDSGQLVRVTARTILRDLTLFPDRLDPSAQVDDALITLLPGESTTFTVHSTPPLDPTALTTHPTLRCVNDFQPHGTGTGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9I5</accession>
    <name>F4F9I5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator PadR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733218.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17305"/>
    <dbReference type="EnsemblBacteria" id="AEB44563">
        <property type="protein sequence ID" value="AEB44563"/>
        <property type="gene ID" value="VAB18032_17305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17305"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_4_0_11"/>
    <dbReference type="OMA" id="ETMHYIL"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="127" mass="14043" checksum="A217D402236B1F47" modified="2011-06-28" version="1">MRSTSRPALREPSYFVLAALIGGPLHGYAVIKRVAELSDERVTLAAGSLYSVIDRLLGEGLIAADGEEIVNGRARRYYRLTDEGYRVLAEEADRLARAARVVMDRLPHRSFPLGSIDHPSIVRTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9K1</accession>
    <name>F4F9K1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17385"/>
    <dbReference type="EnsemblBacteria" id="AEB44579">
        <property type="protein sequence ID" value="AEB44579"/>
        <property type="gene ID" value="VAB18032_17385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17385"/>
    <dbReference type="eggNOG" id="ENOG502Z94V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031194_0_0_11"/>
    <dbReference type="OMA" id="FECGWSW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="568" mass="63208" checksum="67B3CC948EEE0D8B" modified="2011-06-28" version="1">MLLPASKIPALSLDDPDRADDEVIEALNSLGGAIEIPRRLVTVMIDYFRRYTAEDGTPVFGGGGYLTPVEGGPELTEEQRSQDIVDSFAVSVTLTLATIGFVKVYRSATQRRELLAQLDELETMASIRLTAAMVGLLRSFSTFVFTSTDEYGRRLCDMVNQDELPRRELVAALREQLRDTMASLRSVVIGSGRVTEDLDNSDMLFECGWSWGIIAGAEEVPTSESIGRQREGSAENAPYLYFTVIAMDAIEDLNSERTRLLGLLNEEQQRLSRALQLRWELTRTYWATVATFGNRRRWPIEDIPWRTTDGDRTDYYTLQATSLAVKGLLAVGRGGDEELGRIAAVLVELAQRARVTRRATPGESALLVHTPGKRVTLNDDTSKPIMTWVVNEFSTVLLQRAITVAGLLSNARRRSELLELADEVWDHLLLRRIPDGRHRGLWDHAGGAFPGLAPRPEAPSWYLTARVVQALVNAGQLLWDRPFPRAARLSGYAQDLIDEAEYLFDRELMRGTFAGEAMQRSMRSIRASLRQAQLLVDERPGTAAALANTLLLLLNDVTTGQQKASEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA10</accession>
    <name>F4FA10_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_00185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735767.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47121">
        <property type="protein sequence ID" value="AEB47121"/>
        <property type="gene ID" value="VAB18032_00185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00185"/>
    <dbReference type="eggNOG" id="ENOG50309I1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173337_1_0_11"/>
    <dbReference type="OMA" id="VWPSWPD"/>
    <dbReference type="OrthoDB" id="2081112at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="89" mass="9858" checksum="2CA2E7442BC3168E" modified="2011-06-28" version="1">MRFLIVRTSIRAAAEADITAAWAEGHRLRDETTRPEPRRQVVHAEDRDAAFVLARAFATVGAVRSGRQRIKVLPLDDPGGRQTRPDPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA45</accession>
    <name>F4FA45_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumarate reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_00360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735801.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00360"/>
    <dbReference type="EnsemblBacteria" id="AEB47156">
        <property type="protein sequence ID" value="AEB47156"/>
        <property type="gene ID" value="VAB18032_00360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00360"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_2_0_11"/>
    <dbReference type="OMA" id="KYDPLVW"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="355" mass="39508" checksum="9D863D9BF4505BE9" modified="2011-06-28" version="1">MGTKRQFRIWRGDADGGELQDYAVEVNEGEVVLDVIHRLQATDAPDLACRWNCKAGKCGSCSMEINGMPKLGCMTRMSTFEENETVTVTPLRTFPVIRDLVTDVSFNYEKARETPAFAPPADLAPGDYRMQQVDVERSQEFRKCIECFLCQTVCHVIRDHDDNKPAFSGPRYFIRAAELDMHPLDDRTDRKEYAQSEQGLGFCNITKCCTEVCPEHIKITDNGIIPMKERVVDRRYDPLVWLGSKIFRRGQVPQTIVTSEHSPGAVRSSAGGQGVHSHAGGSHDPAAEVQAQQGVNWHREVPRPTAPAVGANGKLPLTELTSDRAAAPSPFGDDVTFPLPPEHLNFAHPEQDEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA69</accession>
    <name>F4FA69_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05020"/>
    <dbReference type="EnsemblBacteria" id="AEB42130">
        <property type="protein sequence ID" value="AEB42130"/>
        <property type="gene ID" value="VAB18032_05020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05020"/>
    <dbReference type="HOGENOM" id="CLU_2959580_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="59" mass="6389" checksum="37B873605C8D30D0" modified="2011-06-28" version="1">MRIDTTRQRTVMIGAPRMRPGDHRIRCGGSRHGRHAGTAGCPAETIGDGGRHVMEEAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAI0</accession>
    <name>F4FAI0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmF</name>
        <name evidence="6" type="ordered locus">VAB18032_11465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732077.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11465"/>
    <dbReference type="EnsemblBacteria" id="AEB43407">
        <property type="protein sequence ID" value="AEB43407"/>
        <property type="gene ID" value="VAB18032_11465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11465"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_1_11"/>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307566" description="50S ribosomal protein L32" evidence="5">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="57" mass="6187" checksum="2C764FBD5F06D8C5" modified="2011-06-28" version="1">MAVPKRKMSRSNTRSRRANWKAAAVATVACPQCKSPKLPHAACSVCGTYNGRQVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAP3</accession>
    <name>F4FAP3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-oxalocrotonate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733313.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17780"/>
    <dbReference type="EnsemblBacteria" id="AEB44658">
        <property type="protein sequence ID" value="AEB44658"/>
        <property type="gene ID" value="VAB18032_17780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17780"/>
    <dbReference type="eggNOG" id="COG3971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060136_4_0_11"/>
    <dbReference type="OMA" id="PDMDWDD"/>
    <dbReference type="OrthoDB" id="1314120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="111"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="24620" checksum="DC3CA82E4C0752FC" modified="2011-06-28" version="1">MIDTIAARLDEAAVTRTALAQFGADAGLDVATAYQVQDALVARRVGRGEAVVGVKLGLTSRAKMTQMGVDEVIWGRLTDAMHICDGGTVDLSGHIHPKVEPEVAFLVEGGAIAAVAPAVELIDSRYRDFRFTLAEVIADNTSASGFVVGPWQPVPDNVDNLGVLLEVDGRVAQVGSTAAILGDPRRALPEAARLAGELRDGWVLLAGAATAAVPLTPGAHVRVTVEQLGTVSLRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAP8</accession>
    <name>F4FAP8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733318.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17805"/>
    <dbReference type="EnsemblBacteria" id="AEB44663">
        <property type="protein sequence ID" value="AEB44663"/>
        <property type="gene ID" value="VAB18032_17805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17805"/>
    <dbReference type="eggNOG" id="ENOG502ZRUV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2557353_0_0_11"/>
    <dbReference type="OrthoDB" id="1832681at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004992">
        <property type="entry name" value="EutN_CcmL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036677">
        <property type="entry name" value="EutN_CcmL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03319">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159133">
        <property type="entry name" value="SSF159133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51932">
        <property type="entry name" value="BMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="82" mass="8442" checksum="B36105A5FAF380AE" modified="2011-06-28" version="1">MILGEVVAKVWPDKILPTLQGRRLVLVRPRSEGPDLVAIDPLNVGVGTVVLIATDEAAAAATGEPTADAAVVALVADSTTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAS1</accession>
    <name>F4FAS1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733341.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17920"/>
    <dbReference type="EnsemblBacteria" id="AEB44686">
        <property type="protein sequence ID" value="AEB44686"/>
        <property type="gene ID" value="VAB18032_17920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17920"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133205_1_0_11"/>
    <dbReference type="OMA" id="TTNTLQH"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="142" mass="15528" checksum="11D52549DA462C43" modified="2011-06-28" version="1">MRNATVMPYRVVDDLPLVRAFVREQAHRLGLTADSTDALALAVNELVTNTLQHTSGGGQVRIWYDDASVYCEVVDSGPMRPVRRAMPTPDAERGRGLAIVARICDEVTAYAESGGTIVRLRFAVRRADPPAGKPAAHDDEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB61</accession>
    <name>F4FB61_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_00610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735851.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00610"/>
    <dbReference type="EnsemblBacteria" id="AEB47206">
        <property type="protein sequence ID" value="AEB47206"/>
        <property type="gene ID" value="VAB18032_00610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00610"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_4_11"/>
    <dbReference type="OMA" id="PSPPTWM"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="112"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="33799" checksum="BA523437BFEC1D65" modified="2011-06-28" version="1">MSDLTSAGAAVGGAPVGGDGPTTEATTGGSGKERSASLWADARRQLVRDPVFVIASLYILAVGSMAAFPKLWTSQDPRNCSTDRSRISPSWEHPFGYDILGCDYYSHAIYGARPSMVIAVMATSAIVIVGGVLGLLAGYYGGWVDAIISRVMDIFFSLPFLLGAIVFLTVIKRQNIWTITAVLFLLAWPTIARIIRGSVISSKDLDYVHAAKAVGARNSRLMFRHILPNAIAPMLVYATIVLGSFVAAEATLTFLGVGLQPPAQSWGIMISVHQVYFLEDPWLLLFPCGLLIGTVLSFILMGDALRDALDPKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBV7</accession>
    <name>F4FBV7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_18275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18275"/>
    <dbReference type="EnsemblBacteria" id="AEB44757">
        <property type="protein sequence ID" value="AEB44757"/>
        <property type="gene ID" value="VAB18032_18275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18275"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_4_11"/>
    <dbReference type="OMA" id="THITEAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="28372" checksum="A0B379B54F8D6C7E" modified="2011-06-28" version="1">MTPPETTLEGLVTPAWVRRPTNLARAVTAELVQRIVRGVHPSGTALPPEPVLCETFSVSRTVVREAVKVLQEKGLVQVRQGAGTMVTPQSMWDMLDELVLAATIAEDDSLAILDDLVVTRRLLESDMAHVAARLAGQETLDRLRALVDRMDELVDDQVAYHDHDRAFHDVIMQASGNRIARGVVRSLESQVVNTARYMGRTQRSLCVASNRGHRRIYERIAARDPDGAAEAMFTHITEAWLVRRKGSGKVPRLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBW4</accession>
    <name>F4FBW4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733419.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18310"/>
    <dbReference type="EnsemblBacteria" id="AEB44764">
        <property type="protein sequence ID" value="AEB44764"/>
        <property type="gene ID" value="VAB18032_18310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18310"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002470_2_0_11"/>
    <dbReference type="OMA" id="ICCHTGG"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307601" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="707"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="902"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1187" mass="125666" checksum="D11BCE2DDDC9BEC5" modified="2011-06-28" version="1">MRRKTTIIGVTLGLLLALALVNPASAAPAFRALLFTKTTGYRHDSIPAGVSMFQQQAAADNFELVHSEDSSVFTPANLATFDVLIMFQTSGMVWTSAAQRQAVEGYLASGKGIVAIHNATDMGIEGEYPWWDQTINAGAHMPEHSPGVLPGTAIVADRKHPSTASLPDRWNRSEEWYNFDKNPRGDVHVLVTADERTYNPGSRAMGPDHPISWCRSVGGGRVWATAMGHAIASYSETHFRNHVLGGVKWAAGNQPGDCGGTVWGNFEKRTLDDNTVDPMALAVAPDGRVLYVQRGGQVKIFKPSTNSTVTAGTLSVYTGGEDGLTGLALDPNFASNGYVYLYHSPASSSTDVNRVSRYTLTGDTLNMSSGVTIIDIPAYRDRTYPEPGHTGGYIDFGPDGNLYIGTGDDVAPNLDPNWQGYAPLDWRSGKHMLDAARTAGNTNDLRGKLLRIRPSAGGGYTIPSGNLYPQGTAQTRPEIYAMGFRNPFRFSIDPANGWVYLADYGPDRNPPTTNRGPEGLVELNVIKAPGNYGWPFCHGDNQPYAPYNPDTGAVGAKFNCAAPVNNSPNNTGLTSLRPVVAPNIWYGYGTSQTFPELGSGGSAPMGGPVYRYNAANPSATKFPPYYDGVHFFYEWSRNYIKEVHFDSATAVTRTNPFLPTTRFNKPMDMEFGPDGSLYLLEWGTNFGGGNSDSGLYRIDYIQGGRTPIAKASGTPTSGNAPLTVQFSSAGSMDPDPGDTLSYQWTFGDGTTSTAANPSKVYTSNGNYTAQLKVTDSSGKSGFANVQITVGNTAPVVTITTPANGGMLTFGDRVSYQISVSDPGGAAIDCSKVFLNPALGHDDHAHETTDYPGCSGTIPTDLLGGHPDGANLFYVLNARYTDNGGAGGAAPLTGHAQVILQPKHKQAEYYSSQSGTRVVEQAGAQSGKRIGDISNNDWVAFTPMSLSGINTVSYRLSSPSGGGTIELRAGSPTGTLLATTPVPATGGWDNYQSTPPVNVTALAGTHTLYLVFKGSGNNWFDLDSHTFGGPGVGTGGPVTPPPGDGVAGRTWTLTAQHSGKLMDVNGVSTADGAQIHQWASTGGNNQKWQAVDAGNGAVYLKAVHSGKCAEVIGGSTTAGAFLQQATCNNSNQQKFTATPTGTSGVYTVKSVPSGLCLDVNSAATTDGARLLQWTCHGGTNQQWRFSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC94</accession>
    <name>F4FC94_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiamine monophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00945"/>
    <dbReference type="EnsemblBacteria" id="AEB47273">
        <property type="protein sequence ID" value="AEB47273"/>
        <property type="gene ID" value="VAB18032_00945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00945"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_4_11"/>
    <dbReference type="OMA" id="VMRGSDP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="TMP-TENI" evidence="3">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="21672" checksum="D30529A3AF53DF23" modified="2011-06-28" version="1">MLLTDRRAARGDLVGVVAGAVAGGVRWVVLREKDLLREERRALADELQPILAEAGGNLIVAGPDPLLAIPVPAAGRPLVALHLSAADPYPPPEADLVGRSCHDEGELSRLTTEDYVTLSPVFPTRSKPGYGPPLRPVGLARLIRLSPLPALALGGIEIPAQVRACVQAGAVGVAVLGAIMRSPDPQQTAAELTSAFEAAPTATVEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCH6</accession>
    <name>F4FCH6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_05885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05885"/>
    <dbReference type="EnsemblBacteria" id="AEB42303">
        <property type="protein sequence ID" value="AEB42303"/>
        <property type="gene ID" value="VAB18032_05885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05885"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_1_11"/>
    <dbReference type="OMA" id="LMLRFKK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309232" evidence="3">
        <location>
            <begin position="27"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="19957" checksum="D3D86739D2057039" modified="2011-06-28" version="1">MAAPRLVVGLLSVALAAVLTGCTGGGRESTCDSANGIVECGPEQRSDAPKITGELLTGGSYDVADQRGQVVVVNFWGSWCAPCRAEADDLEGTYQATKDSGVTFLGINVQDSRDKAIAFEEGRVSYPSIFDPGSRLALDMDIPPNTIPATVVLDREGRIAVVIRAAVRQEGLQPIVERIAAESPAPSGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCM8</accession>
    <name>F4FCM8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732191.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12040"/>
    <dbReference type="EnsemblBacteria" id="AEB43522">
        <property type="protein sequence ID" value="AEB43522"/>
        <property type="gene ID" value="VAB18032_12040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12040"/>
    <dbReference type="eggNOG" id="COG3214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043035_1_0_11"/>
    <dbReference type="OMA" id="FEYWAHE"/>
    <dbReference type="OrthoDB" id="1594634at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="409" mass="45077" checksum="0F6A4102F80069A4" modified="2011-06-28" version="1">MAAPESLSLAQARRIALTAQGFADPLPTGAPTRRHLRRVLDRVGLIQMDSVNVLQRAHYLPLYSRIGPYPTSLLDSAAYRAPRELFEYWGHEASLVPVGLHPTLRWRMARAHDDAWGGMRGIAQEQPQLVAWVRDEVAARGPLTAAEIEHDAPRTTGNWGWNWSAVKQALEFLFWAGEVCAATRTTSFARRYDLPERVLPAEVLAAPTPTVAEAYRTLVGIAARSLGVAAEPELRDYFRLPVAGARQAIAELVEAGELRPVTVQGWRHPAWLHTDARLPRWVRGNTLVSPFDPLIWERARAERLFDFSYRIEIYVPAAKRVHGYYVLPFRQGERFTARVDLKADRKAGVLLVPAAWIEPGADPGETAVALAAELYRLAGWLGLDAVAPPAAGDLAAPLAAALLGVSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCW2</accession>
    <name>F4FCW2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733449.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18460"/>
    <dbReference type="EnsemblBacteria" id="AEB44794">
        <property type="protein sequence ID" value="AEB44794"/>
        <property type="gene ID" value="VAB18032_18460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18460"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_1_4_11"/>
    <dbReference type="OMA" id="THDVLIC"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="20754" checksum="326A29588DD8CCB9" modified="2011-06-28" version="1">MNVQPEPTAEPCDPVQLRRAFGTFATGVTVVTVGGECPHGMTANSFTSVSLDPPLVLICVDQQAIMHRSLIECGQFGVSVLAAHQEPVARHFADRRRPLGAAQFDAVDWVPGRLTGAPLIVGALAHFECELWRSYDGGDHTIFVANLLAVRREPEADGVLFVRGRFRQLDRDGIDVADGVPAWQAAVRGGVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCY0</accession>
    <name>F4FCY0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733467.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18550"/>
    <dbReference type="EnsemblBacteria" id="AEB44812">
        <property type="protein sequence ID" value="AEB44812"/>
        <property type="gene ID" value="VAB18032_18550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18550"/>
    <dbReference type="eggNOG" id="ENOG502ZNK6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229487_0_0_11"/>
    <dbReference type="OrthoDB" id="1862416at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312910" evidence="2">
        <location>
            <begin position="29"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="225" mass="23708" checksum="3D0DDAF0910AB46F" modified="2011-06-28" version="1">MSRIARTVLVVVGAVLGLSLLAPSSAAAADEYTLQVHTSGAAFLYTLCLKTDTTMKEPRGSDRVCTGKRGSTHGTFDMSAPYAPGDSVKMDIEMHTGLAGESVTKDNVDITGARSCTLSGAVHAGKFQCDSPINTINFEPPEITAYTVDTNPNKSVANLLNLMAWLVSAAAVAGLLITGATLAAQLRRGAMEERTEYTRSIAFVFTACLIATTAGPFVRWLALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD07</accession>
    <name>F4FD07_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, gntr family with aminotransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44839">
        <property type="protein sequence ID" value="AEB44839"/>
        <property type="gene ID" value="VAB18032_18685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18685"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_11"/>
    <dbReference type="OMA" id="ARVFVCQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="450" mass="47307" checksum="431A2F6BA9FE058C" modified="2011-06-28" version="1">MAAAGPGTRLPSVRELTGRHRASPVTVAEAIRHLVREGLIETRPGQGTYVAARAVEPRTVDLSWQTVALGPRRPGDDQLQALLALPPAGAIPLSGGYLDPELQPAAALGAALTRAARQPASWQRGPVEGRADLRAWFAREIGGGLRAEDMAICPGGQAALSTALRALAAPGDALLVESPTYLGALAAAEAAGLRVVPVPADADGVRPDHLAAAFARTGARLFYCQPLYANPHGATLAAHRRALVAEAVRDAGAFLIEDDYARDLTIDGPAPPPLAADDRDGHVVYLRSLTKSAAPGLRVAAIGALGPAGARLRAARLLDDFFVAGPLQQAAIEFVTAPAWARHHRALRTALRDRREALLTALRRHLPDLVDRLPVPRGGLHLWLPLPEGTDDVAVATAAAAEGVVVFPGRPWYAAEPPAAHLRLTYAAAAPEMMDEAVRRLARVLRQPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD97</accession>
    <name>F4FD97_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734779.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25145"/>
    <dbReference type="EnsemblBacteria" id="AEB46127">
        <property type="protein sequence ID" value="AEB46127"/>
        <property type="gene ID" value="VAB18032_25145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25145"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_11"/>
    <dbReference type="OMA" id="YHGRRPM"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="196" mass="21229" checksum="A8283E658314A4A6" modified="2011-06-28" version="1">MMLPLPAGDFKAYLFDCDGTIVDSMPQHYTAWRQALDEWGCEFPEELFYAWAGRPTADIVAALNEQQRLNMPLEAVIARREALYQQLLPSAAGIPGVLHHIDDAHGRIPFAVVSGSTREAVTASLGALGILDRFDVLVCAGDYTRPKPDPEPFLRAAELLGVPPEACLVFEDADLGIESATAAGMAAVRVPQPRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDA4</accession>
    <name>F4FDA4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_25180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734786.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25180"/>
    <dbReference type="EnsemblBacteria" id="AEB46134">
        <property type="protein sequence ID" value="AEB46134"/>
        <property type="gene ID" value="VAB18032_25180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25180"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="OMA" id="LWYSVQS"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="111"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="333" mass="36208" checksum="AF5447590DD444B6" modified="2011-06-28" version="1">MSVNATPAGADVAADGTDTRSTGRHAAVPAQRDNRRRKPPLSENKRAERRLGLLLCAPAALVMLAVTAYPILYSVWLSLQRYDLRFPAEREFVGLQNYVTVLTNEFWWTAFGVTMLITVVTVAVELVLGMGLALIMHRTLVGRGIVRTSALIPYGIVTVVAAFSWRYAWTPGTGYLANLFSDGAPLTERASSLAIIMLAEIWKTTPFMALLLMAGLALVPEDLLKAASTDGATAWQRFTKVMLPVMKPAILVALLFRTLDAFRVFDNIYVLTSGANETSSVSMIAYNNLIRGLNLGIGSTMSVLIFITVAIIAFVFVKLFGTAAPGSDDGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDB3</accession>
    <name>F4FDB3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="11" type="ordered locus">VAB18032_01200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735961.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01200"/>
    <dbReference type="EnsemblBacteria" id="AEB47324">
        <property type="protein sequence ID" value="AEB47324"/>
        <property type="gene ID" value="VAB18032_01200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01200"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_11"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="10">
        <location>
            <begin position="310"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="883"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="959"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="966"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="969"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB47324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1295" mass="144360" checksum="293618D9A06FFA4B" modified="2011-06-28" version="1">MLDVNFFDELRIGLATADDIRQWSHGEVKKPETINYRTLKPEKDGLFCEKIFGPQRDWECYCGKYKRVRFKGIICERCGVEVTRSKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFASYVVTSVDAESRHRDLSTIENEILAEKRQSENSRDSEIEKRAAKLEADLAELEAEGAKADVRRKVKEGGEREMRQIRDRAQREIDRLDEVLDTFRKLEPKQLVTDELLYRELRDRFGEYFTGGMGAEAIKALVQNMDLDAEAESLRETIRTGKGQRKIRALKRLKVVAAFQNTRNSPLGMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKLHQCGLPKQMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPVVWDVLEEVIGEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQIHPLVCTAFNADFDGDQMAVHVPLSAEAQAEARILMLSSNNILKPADGKPVTMPTQDMVIGLYHLTHLTTGERGEGRAFSSDAEARMAYDNGELHLQAPVKIRLQGVVEVDNGAGAQPWTAPEGWTQGEPLTVETTLGRVLFNETLPQGYRYVNYEIRKGQLSAIVNDLAERFPKVALAATLDGLKEAGFHWATWSGVTIGMEDVIAPPRKREILEKYEKEADRIDKQYQRGLMTAEERRGELIEIWTKATNEVAKEMDTALPQENPLWKMINSGARGNLLQLRQIAAIRGLVANPKGEIIPRPIKASYREGLSVLEYFISTHGARKGLADTALRTADSGYLTRRLVDVSQDVIIREEDCGTDRAIPMQIGQQLDGRLVVHEHAETSVHARTLADDIKGPDGTVVAERGSDINSILVDKIVAAGVETVRVRSVLTCESKLGVCGACYGRSLPTGKIVDVGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGEDITQGLPRVQEIFEARIPKGKAPIADTPGRIRIEDGERSRKIVVIPDDGSDEIVYDKISKRVRLRAHDGDHVEVGEKLTEGTIDPHELLRILGPRAVQVHLTQEVQEVYRSQGVLIHDKHIEIIIRQMLKRVTVIDSGSTEFLPGVLVDRALFESENRRLVGEGGEPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAIHARSDSLIGLKENVIIGKLIPAGTGISKYRNVRVEPTEEAKAKVYSMTGYPETDYGFGPASGQAVPLDDFDFGSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDD0</accession>
    <name>F4FDD0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01285"/>
    <dbReference type="EnsemblBacteria" id="AEB47341">
        <property type="protein sequence ID" value="AEB47341"/>
        <property type="gene ID" value="VAB18032_01285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01285"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033540_1_0_11"/>
    <dbReference type="OMA" id="RIHASAY"/>
    <dbReference type="OrthoDB" id="895136at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="42264" checksum="D542C98EBEA0057F" modified="2011-06-28" version="1">MPIGRRVAYLRVRRRLSQQTFADRLGKSKSWVDKVERGVRSLERVSTIRDIAAVLRVDAATLLGHDEQPAELVDRNEGVARIRTALSAYEISPGRPPGRRPPMSPQRLDQELAHAWSTYQHARYPHLIELLPTLLTEVHRAPAQAPQACRAALVEAYRITAALLAKLGERSLAWLAADRAMSAATGDQLLVACAAVQLGQALPASSRARSVMLAAAYQAAPPDLDAGTPQELSLCGTLLLEAAMMAARSGDERATAGLLDEAAEMAARVGDGQDHHHTAFGPTTVELARTAAAIEAGDTRQAVTRHQKIIGYDGWRCLPVERRAAHLIDAARAYLHAGAPSAAARVLLQADHIAPAEVRHRPAGRDTVAQVARDPEAPTTITQLALTLGLLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDF8</accession>
    <name>F4FDF8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736005.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01425"/>
    <dbReference type="EnsemblBacteria" id="AEB47369">
        <property type="protein sequence ID" value="AEB47369"/>
        <property type="gene ID" value="VAB18032_01425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01425"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_11"/>
    <dbReference type="OMA" id="YTLGGQH"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="50"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="35748" checksum="CF1296BD24A83923" modified="2011-06-28" version="1">MKPAILSPDRLLPAHSVPPPWPGRQVRLDGTVTYVRDTPATRPDAEPALYVHGLGGSSQNWTDLAGLLADRLDGQAIDLPGFGRSEPGRRYTVPVFAQRVIRWIEHSDRGPVHLFGNSLGGAISVRVAALRPDLVRTLTLVSPALPFLDFRRSLQGRMLPVLAVPRGERLVAWRLGQMAPEVMARQVMEACVADLSRISDQRRQEALEEIRVRYQAEHHAAAYVRTFRGLVYSFLRSYLPGSDSLWRLARSVQAPTLVVGGRRDRLVDVRVAPQTARMIPDSRLLMLDGVGHVAQLEVPRLVARAVVGLLTETGDARSRADLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDT4</accession>
    <name>F4FDT4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_12505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732284.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12505"/>
    <dbReference type="EnsemblBacteria" id="AEB43615">
        <property type="protein sequence ID" value="AEB43615"/>
        <property type="gene ID" value="VAB18032_12505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12505"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_0_0_11"/>
    <dbReference type="OMA" id="QAFWRVA"/>
    <dbReference type="OrthoDB" id="1783638at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313826" evidence="5">
        <location>
            <begin position="22"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="53"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="308"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="511" mass="53028" checksum="9CD1AE2BB1E71151" modified="2011-06-28" version="1">MRRLAPRPALLAASTAAVAVALIPLAYLAVRTAEAGWDRIAAELWTERVGLLALRSIGLAAVVTTACVLLGVGTAFLVTRTDLPGRRIFAVLAALPLAVPTYIAAFAWVSTVPQWEGFWPAALVLTLCSYPYVLLPVAAALRGADPAQEEVSRSLGRSGWQTFTAVTLRQIRPATAAGALLVALYVLSDFGAVSILRADTFTRAIFVAFDMGFDRTGALVLSCVLVALTVLLLTGETATRRRGARYSQLGGARRPVSRLPLGPARWPVIAVLVGVAGLALGVPAVSLGRRLAAGVSRPGALPEVLAAAGNSLTVSLAGAALTMLLALPLGLLTARAPGPLTSLLDRLAYLAHALPGVVIGLSLIFFGINVAYPLYQTWWLLALAYATLFLPLAVGAVAGAAAQSPAGLEEVARSLGRGPWTVLRTVTLPLILPGIGAGAALVFLTGMKELPATLLLRPTGMDTLATELWTSTAVGAYAAAAPYAALLVAISALPTWLLVARSGLLDKEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDW5</accession>
    <name>F4FDW5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12660"/>
    <dbReference type="EnsemblBacteria" id="AEB43646">
        <property type="protein sequence ID" value="AEB43646"/>
        <property type="gene ID" value="VAB18032_12660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12660"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016537_0_0_11"/>
    <dbReference type="OMA" id="MWEWFFA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="597" mass="64935" checksum="A9B54FD8477818AC" modified="2011-06-28" version="1">MLAIGAYVLLGVVVCLNYWVDVNNRVSSHLPTDHSWFEWLFSHGAYSLRNLENPLFSTQQNAPDGVNMMANTSLLGVTLPLAPLTWLLGPQVVYALYLGGALAATAGTAYWMLSRHLVRSRAAAFIGGGFLGFAPGIVHHANGQPNFVSNFLLPLIVVRVFRLTEPGRWRRNGLVLGLLVAYQIFINEEMLLLTALACLVVVIAYAIMRPRAARQRAGTFAAGLGVGGGLALLLTAYPIWFQFNGPQSYRGLQGGVFHSWGEDIVAFVTFPRDTIAGTEAVEKTIGMTEQNTWFGWPLVLVCVVALALLVRRCMVARILAVLVVFFSVAALGPEIRFNGELTGIGGPWSYIPEDLPLVEMMMPTRLTLVTTAALGVLLALAWDAVAGHGRPPVPAPRAPHPAEGSAGVSEPASSSESAGLGRRPRWQQAVGYAAITLAVLPLIPTPLPAERVDPPPTFITSGAWRPYVPDGRTLVPVPIPSNVHGLSTLRWSALTQHQFPIPAGYFIGPNLDGEGVFGAPNRHTSTLIYRSMDTGELPELTDEDRQRAVEDLRFWRASVVVLGAHPREAVLRELMTALLGEPQRIDDVWLWDVRDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE96</accession>
    <name>F4FE96_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Restriction modification system DNA specificity subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_25320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25320"/>
    <dbReference type="REBASE" id="34487">
        <property type="entry name" value="S.VmaORF25315P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46162">
        <property type="protein sequence ID" value="AEB46162"/>
        <property type="gene ID" value="VAB18032_25320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25320"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_10_2_11"/>
    <dbReference type="OMA" id="WSPQCED"/>
    <dbReference type="OrthoDB" id="827072at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="224"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="428" mass="48091" checksum="0AD2AC7BD3D2E1A1" modified="2011-06-28" version="1">MTDGSWPRMRLKSLVEPVQTGVWGAEPAGDNDDILCVRVADFDRQRLGLKSVETVRSVSEADRATRLLRAGDILLEKSGGTEAKPVGFTVMFDGGYPAVSSNFIGRVRMRDGQHPRFWLYALAASYLTRRTQKCVRQTTGIQNLDQGAFFNEVFAVPTLGEQRAIADYLDRETTRIDTLIEEQQHLIEMLRERRNALRVHVALHGTRQVAEVESPLPWASKIPASWRVVPLTSVAQLESGHTPSRSREDWWTDCYIPWVSLHDVGAMRGTKYLHDTEQRISDAGIANSSARLLPARTVVLSRDATVGRTAIMAVPMATSQHFAAWVCGPLLDPEYLWVLFADAMQPFFDSFQNGSTIRTIGMGDLKAFRIPLPPLDEQRRIVEYLDEETPKIDTLIVETERFIELARERRAALITAAVTGQIDVREMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEC6</accession>
    <name>F4FEC6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734844.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25470"/>
    <dbReference type="EnsemblBacteria" id="AEB46192">
        <property type="protein sequence ID" value="AEB46192"/>
        <property type="gene ID" value="VAB18032_25470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25470"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="OMA" id="FWGWQAH"/>
    <dbReference type="OrthoDB" id="1322538at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="435" mass="46221" checksum="5B1EDDFF40F1EBC2" modified="2011-06-28" version="1">MTSDDLLARHRAVLPSWMPLYYADPIEVVSGEGRRVTDAQGRTYLDFFGGVLTNMIGYDIAEIREAVQRQLATGIVHTSTLYLIRQQVELAEKIARLSGIPDARVFFTNSGTEANEAALLMATNHRRSHQVLAVRNSYHGRSYATMGITGNRGWSASQLNPLQVAWLHSGERLRGLLSRLPEADRIDAAVEDLREVLATQTSGDVACLLAEPIQGVGGFVHGPDGLFAAWKKVLDEHGILLVSDEVQTGWGRTGEHFWGYQAHGVTPDLLTFAKGIGNGFALAGVVGRAEVMESVPAISFSTFGGNPISTAAGNAVLDYLLDHDLQANAARTGAILVDGLRAAVGGLDCVAEVRGKGLMLGVEFVRPGTAEPDAALAAGVFEACRAGGLLVGKGGLYGNVLRMGPPLTLTEDEAREGLAILVEAIRSCAAEAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FED7</accession>
    <name>F4FED7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46203">
        <property type="protein sequence ID" value="AEB46203"/>
        <property type="gene ID" value="VAB18032_25525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25525"/>
    <dbReference type="HOGENOM" id="CLU_1969599_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="127" mass="13208" checksum="26FEA2148F78612A" modified="2011-06-28" version="1">MVDAVAVGPVANATPPTLSTSIAAIAAGPKIDLGLTIMLLRLRVAPDARKVPLHRWWWSMSSPCSAYPSGTDVPTADPGAAVKRFGGTRSGSASPVGRRRGLAHSPESRTGSGRVKRVPGSRSDRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEG7</accession>
    <name>F4FEG7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736044.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01625"/>
    <dbReference type="EnsemblBacteria" id="AEB47409">
        <property type="protein sequence ID" value="AEB47409"/>
        <property type="gene ID" value="VAB18032_01625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01625"/>
    <dbReference type="eggNOG" id="ENOG5031IER">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159294_1_0_11"/>
    <dbReference type="OMA" id="WATNGRN"/>
    <dbReference type="OrthoDB" id="1687192at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="110" mass="12152" checksum="7FE4F31D2C8C8F6A" modified="2011-06-28" version="1">MGRLMLDTSRVSYEVSVNPVPKLDQNGQQKFDRETKQPMWTVHLYALSEGIAEVINVTVVSPTVPPVAVRQPVLPVDLEALPWVNDRDGKVRSGVAFRASGLRPIETGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEI9</accession>
    <name>F4FEI9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylyl cyclase class-3/4/guanylyl cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_01735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736066.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01735"/>
    <dbReference type="EnsemblBacteria" id="AEB47431">
        <property type="protein sequence ID" value="AEB47431"/>
        <property type="gene ID" value="VAB18032_01735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01735"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_5_2_11"/>
    <dbReference type="OMA" id="PRDGEYA"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="934" mass="100022" checksum="742D9A1380982BB6" modified="2011-06-28" version="1">MSSRIHLPSGWVTFVFTDIEGSTRLAQLLGPGYRPVLAEHRRLLRRTIAATEGAELLTEGDSFFLAFGDAGAALTACLTAQRALREHEWPTPEAAPRVRMGLHTGWAEPRDGEYASPEVHRAARVAAAAHGGQVLCSAATAQHADPLPAGASLLDLGLHRLRGFDDRERLFQLVAAGLELQFPRPRTADAEAHNLPVQVTSFIGRQAERAELRQLVARHRLVTVLGAGGGGKTRLAVELATDLVEEYPDGVWFVDIASVTDPGLVAFAIAAVLGLRPEPGRPMVDTLVEYAANRRMLIVLDTCDAQPAACADVVTRLLAGGGGVRVLATTREPLALPGEVVWRIPPLSVDPSPDGTESDAVALLLDRTAAARGGRQPDPAESADLRRVVRRLDGLPLAIELAAARLRVLSVGQLAERLDDVLGTLDAGRDDPPSSAAGVPVGSWGDGAGAAEHDRPERSARTAVERHLTMQATVTWSYRTLGPRAARLLRWLAVFAGPVDLDTVEWLLGDDPLDPLSVLVDKSLVLAEPHASGYTYRMLDPIRAYAARRLIEAGEEQDARNRHVAWSVHALEQAHLGADGQPVTLSLYSLDPLAGELRAALRWCATGGSARIGLRLAGGLEQWWRERGLAREGRLWLFRLYSRIAETGEVIPEGELAAAYHLHSLHAGADGEYAEELRYSQRAEAAARQAGDVGLLARVLAGRAAALVDMGQFAEAERICREVIDWAHDQGVESEALFAVCRLAELLWLRGALDEAAELLGAARPVEAARPVERGRRSVDMLLGMVALARGDLVAAHEHLLAALRSRMNHGFHGRACDTLNAIAVRCAVGGAPLTAARLFGAAQATRASLRSTPGIYDAYWTQQQVALRRVLGDATFDEAYGEGAEFGLDEAVALALGVEHPDLAADSARFAGRAGAGVPRQSAAAADRHSEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEP6</accession>
    <name>F4FEP6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06580"/>
    <dbReference type="EnsemblBacteria" id="AEB42440">
        <property type="protein sequence ID" value="AEB42440"/>
        <property type="gene ID" value="VAB18032_06580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06580"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025436_1_0_11"/>
    <dbReference type="OMA" id="KAYGVVR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="551" mass="57633" checksum="83B64A2E7E628FF9" modified="2011-06-28" version="1">MGAMPLSSHSERSLLGRTVGTGIRAIRLLFRGSVNGGRWVTRSAARARARGAGGETGMVRMFDLHAVSCAGDTLIAIGLAGTIFFNVPLGEARSKVALYLLVTMVPFAMLAPVVGPLLDHFRHGRRYALATTMLGRAFLAWMISDYIHGFGLYPAAFGVLALSRAYGVARSAAVPRLLPEGLGLSQVGARASVYGTVAGALVAPIGLAAFWFGAQWPLRVASVIFLVGMVIALRLPPRADSEPPERVPRPLRALRRATGDRPLGRGRPAGRLVISNLVGAATLRALYGFLLLFLAFTIKAGDLTTVLFGRDLGDKGALGLVGGALAVGTFLATALGTRLRIHRPTALQSSGMIIVAGVAVLATLYFSLLMVTLLCVVAAMMSGIAKLAVDASIQERIPERLRASSFAHSETVLMLAFVAGGGLGLVPFHGRIGIAVAAGVGVLAAARGLLMAHRLRAERLCGRPLTDEELKATERDADARAAKDQADRDRKAAEDAEDIAPTSPAPVQGGSTPPEPDLAPPGFHIYRPSSTVTGSGSGEDEPRRSSPGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FES6</accession>
    <name>F4FES6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731143.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06730"/>
    <dbReference type="EnsemblBacteria" id="AEB42470">
        <property type="protein sequence ID" value="AEB42470"/>
        <property type="gene ID" value="VAB18032_06730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06730"/>
    <dbReference type="HOGENOM" id="CLU_1748894_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="149" mass="14832" checksum="6F01CCE62508C7A8" modified="2011-06-28" version="1">MPSLAFTRPLWSVTRCPLADLARLALTALILAVGLGGITTTGLPDGTADLPAAPPAAALPNRPGNAPATARALWPGNDESTLISPWNASALFSRDGSALVSPVGAVHAAAVVPHSERTDAGAAPASTRPAAVRLAAGPGEPTRRGPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F4FET4</accession>
    <name>F4FET4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Copper-translocating P-type atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_06770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731151.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06770"/>
    <dbReference type="EnsemblBacteria" id="AEB42478">
        <property type="protein sequence ID" value="AEB42478"/>
        <property type="gene ID" value="VAB18032_06770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06770"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_11"/>
    <dbReference type="OMA" id="ITFFGWM"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="748" mass="77132" checksum="85D93A696C5CA6BC" modified="2011-06-28" version="1">MNTSRPLPTATGRIELSIGGMTCASCAARIEKKLNRLDGVQASVNYATEKATISYDAPVTPDDLIATVEQTGYRASLPAPATAPATTDEPVDELRSLRTRLWVSVALTVPVIALAMVPAWQFTYWQWLSLVLAAPVVVYGGLPFHRAALVNLRHGAATMDTLVSVGTLAAFGWSVWALFLGTAGTPGMTHPFSFDIGRTDGAGNIYLEAAAGVTAFILAGRYFEARSKRTAGAALRALLELGAKDVSVLRHGVETRIPVEQLAVGDRFVVRPGEKIATDGTVDEGSSAVDASLVTGESVPVEVGVGDAVVGGCVNAGGRLVVTATRVGADTQLAQMARLVEQAQSGKAAAQRLADRISGIFVPIVLLLAAGTLGWWLGSGAGPTAAFTAAVAVLIIACPCALGLATPTALLVGTGRGAQLGVLIKGPEMLESTRRVDTVVLDKTGTVTTGRMTLLEVIPGAGERRDETLRTAAALEAGSEHPVARAVVAGAAEVGELPPVTGFANVAGLGVSGTVEGREVLLGRPRLLRERGLVVPDDLARAATDAQAAGRTAVLVGWAGRARAVLAVADQVKPTSREAVRRLRDLGLTPVLLTGDNATVAAAVAAEVGIDEVIAEVLPAEKVDVVSRLQAEGRVVAMVGDGVNDAAALAQADLGLAMGTGTDAAIEASDLTLVRDDLLAAVDAIRLARRTLGTIKGNLFWAFAYNVAALPLAAAGLLNPMIAGAAMAFSSVFVVANSLRLRRFRPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEX4</accession>
    <name>F4FEX4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_12860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12860"/>
    <dbReference type="EnsemblBacteria" id="AEB43686">
        <property type="protein sequence ID" value="AEB43686"/>
        <property type="gene ID" value="VAB18032_12860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12860"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033996_0_0_11"/>
    <dbReference type="OrthoDB" id="623081at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0270">Exopolysaccharide synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Stealth_CR1" evidence="6">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR2" evidence="5">
        <location>
            <begin position="221"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR3" evidence="7">
        <location>
            <begin position="372"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR4" evidence="8">
        <location>
            <begin position="447"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="541" mass="60288" checksum="F91B082AFE0D9806" modified="2011-06-28" version="1">MVEQATPLALWQRNLDLVTQTLDKAGIDYFCVRHADDLRSAVAVPLARKGETLRVLQELAGQPQVTVSVVNAQGKQVSASEQGAIVQVFHCVSDPGSTTIIGSRFASEVEFWQLVTPSDRPTAEIVAPRGNQVAASLPAQGEPVTVPASRLTRFAPERGEPGRYRSRAEFAGLGHEHVTFPIDAVYTWVDGNDTDWLERKNRALRQQAGAEINEVALDPSRYVSRDELRYSLRSLVGFLPWIRMIYLVTDDQIPPWLDVDHPMIKVVRHRDIFRDTGQLPTFNSHAIESRLHRIEGLSEHFIYVNDDMFFGRPLLPTKFFHANGIAKFFPSPAQLDVGPATIHDAPVTAAGKNNRRHIQDRFGRTITQKMRHVPYALRKSVLEDIERQLTDEVLGTADHQFRHPADLSIPSSLQHYWSYFSGKATPATIAYTYADLAHPATPVQLARLLARRDRDAFCLNDTESAEVSIPEQHAMLTEFLTAYFPFRAPFELPADVEAERARHTATALASASLPRHATPAAARPSRDGQVDGAIGDREPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEY6</accession>
    <name>F4FEY6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid pRiA4b ORF-3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12920"/>
    <dbReference type="EnsemblBacteria" id="AEB43698">
        <property type="protein sequence ID" value="AEB43698"/>
        <property type="gene ID" value="VAB18032_12920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12920"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085055_2_1_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878">
        <property type="entry name" value="PTHR41878"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="18343" checksum="C87F5D2FBF33E223" modified="2011-06-28" version="1">MLVPGGYTLDRLHRVVQHAMGWRDCHLHSFEIDGVQYGEPDPDGDLALDDELTLHDELDVRLDAVAGKGSRLQYTYDFGDWWEHDLLVEDVVTADADERYPRCVDGERAAPPENVGGAQGYLLLLAAVADPGHPEHAAMRAWVGDGFDPEAFDAGRVTTLLRRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF01</accession>
    <name>F4FF01_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
            <ecNumber evidence="4">2.3.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_12995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12995"/>
    <dbReference type="EnsemblBacteria" id="AEB43713">
        <property type="protein sequence ID" value="AEB43713"/>
        <property type="gene ID" value="VAB18032_12995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12995"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_2_11"/>
    <dbReference type="OMA" id="MDTHGFG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="35"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="380" mass="38603" checksum="D1D77F1846D204A8" modified="2011-06-28" version="1">MAVADWLAALTRRADLRAKAGLTRRLHPRAAADAVVDLAGNDYLGLSTHPQVIAAAAQALSRYGLGATGSRLVRGSTEAHHALEDTLAGWLGTERALVFSSGYLANVGAVRALVRPRTLLVSDAHNHASLIDGCRISGAQTVVTPHADVAAVAAALAAAPGRPAVVVTESVFSVDGDLAPLVDLHRVAREHGALLLVDDAHGLGVTGPAGAGAVAAAGLAGEPDVVVTATLSKALGGAGGVVAGPAEFVRHLVETARTFIYDTALPPAVAAGVHAAVEVARTGDDRRAVLTERAATAVRRLRAAGLDVSTPDAAVVSVTAPSPQAATEWAAACRDRGVAVGCFRPPSTPDSRSRLRLTIGAGVPRADFEHALEVIVECAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF21</accession>
    <name>F4FF21_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, luxr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_13095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732401.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13095"/>
    <dbReference type="EnsemblBacteria" id="AEB43733">
        <property type="protein sequence ID" value="AEB43733"/>
        <property type="gene ID" value="VAB18032_13095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13095"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="PHVLTHM"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="23081" checksum="03C16E1FC85E0E29" modified="2011-06-28" version="1">MIRVFLLDDHEVVRRGLADLLHASGDIEVVGESGSAQEAARRIPALRPDVAILDARLPDGNGIDVCRDIRAVDSSIKGLILTSYEDDEALFAAIMAGASGYVLKQIRGTDLVDAVRRVAAGQSLLDPAITTRVLDRIRSGVEQPRELQSLTEQERRILEYVAEGLTNREIAGKMFLAEKTVKNYVSSVLAKLGLERRTQAAVLATRLLGKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF54</accession>
    <name>F4FF54_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">VAB18032_19285</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733614.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19285"/>
    <dbReference type="EnsemblBacteria" id="AEB44959">
        <property type="protein sequence ID" value="AEB44959"/>
        <property type="gene ID" value="VAB18032_19285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19285"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_11"/>
    <dbReference type="OMA" id="VMWQMSD"/>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="16">
        <location>
            <begin position="84"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB44959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="753" mass="81952" checksum="59E97D2579C1B1D1" modified="2011-06-28" version="1">MESRNPAKAVKDVVESAAEKVTEALTPQVPGAPGSAPPSLAEPTTPHDPLPPKPEQGAPQTRTPTGAKTGTPPTAKGQQGAFLTTAQGARLRDTDHSLKAGPRGPVLLQDHHLREKITHFDHERIPERVVHARGAGAHGLFTAYGTAENVTRAGFLRKGRETEVFVRFSTVLGSRGSADTVRDTRGFATKFYTDEGTFDLVANNMPVFFIQDAIKFPDIIHAAKPHPDREIPQAQSAHDTFWDFVSLHTEAQHHTMWNMSDRGIPRSYRTMEGFGVHTFRMVNAAGETALVKFHWKPKLGVHSLVWEEAQLLNGIDPDFHRRDLYDAIEAGAFPEWELGIQVFPDTPEETFAGIDLLDPTKIVPEELAPVQPIGKLVLNRTPTNFFAETEQVAFHVGHLPPGIDVTNDPLLQGRLFSYVDTQLTRLAGPNFSQIPINRPHAAVNDMLRDGFHQHAIHAGVAPYRPNSLDGGNPFPAGDDDHPFIDVPVQVAQAPKVRQSPASFDDHFSQARLFWLSMSPVEQEHIIRAYTFELGKCYHQAIKERQLQCLANIDPVLCAQVATGLGLPAPKPTVPLADVEPSPALSQVGRQWPVDGRTIGIVVTDDSDLDTIHQVRRAVFAADMVPLLIVGHGGMIGDLPVQRTFATGRSVEFDALLLAAAPPPAPDALPARDAKAGAADSATVDPRVLLLVEEVWRHAKAIGAWGAGVTVLEQAGVTASPGVVTGDSGDDVFDAVRQLMTHHRVWERFPASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFB1</accession>
    <name>F4FFB1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">araA</name>
        <name evidence="8" type="ordered locus">VAB18032_19570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733671.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19570"/>
    <dbReference type="EnsemblBacteria" id="AEB45016">
        <property type="protein sequence ID" value="AEB45016"/>
        <property type="gene ID" value="VAB18032_19570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19570"/>
    <dbReference type="eggNOG" id="COG2160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045663_0_0_11"/>
    <dbReference type="OMA" id="HMLEICP"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="362"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="500" mass="54633" checksum="1D1D694E6C489926" modified="2011-06-28" version="1">MAAQPEPEVWFLTGSQAMYGEDTLRQVAEQSRQIAALLDDSPHIPARVVWKPVLTTSADILKVCQDASVHGAVGVIAWMHTFSPAKMWITGLDALRTPLLHLHTQANVQLPWHEIDMDFMNLNQAAHGDREFGFIQTRLGVARKTVAGHVTDPRVVSRVGAWTRAAIGWSAMRSLRLARFGDNMRDVAVTEGDKVEAELRFGVSVNTYGVNDLVTAVDEVAEAQIDDLVKEYDDTFRVAAELRPGGDRHDSLRYAARIELGLRTFLDAGGFRAFTTNFEDLGGLRQLPGIAVQRLMADGYGFGGEGDWKTSVLVHTVKAMAVGAEGGTSFMEDYTYDLTPGQELILGAHMLEVCPTIASGVPNVEIHPLSIGGREDPVRLVFDAAPGPAVVLGLADMGERFRLVANEVDVVAPPQPLPKLPVARAVWQPRPSLAGSAEAWITAGAPHHTVLSQGVGVEELHDLAEMARTELVVIDADTEPRRFANELRWNQAYYRLARGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFY3</accession>
    <name>F4FFY3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldolase_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07195"/>
    <dbReference type="EnsemblBacteria" id="AEB42563">
        <property type="protein sequence ID" value="AEB42563"/>
        <property type="gene ID" value="VAB18032_07195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07195"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_11"/>
    <dbReference type="OMA" id="GREAHDW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="24980" checksum="A34A3BD4D145371E" modified="2011-06-28" version="1">MEQLAATLRLFAELGYDEGAGGHITARDPERPDCFWINPFGMYFGHVRVSDLLLVDADGKVLGGKGRINPAGFVIHSAVHAARPDVICAVHTHSVYGRAFSTLGRLLDPITQDACAFYGDHALFDDYTGVVLDSEEGKRIATALGAGKAAILQNHGLLTVGGSVAEAAWWFVAMERSCQVQLAAEAAGKPILIDHEDAERTREVIGSPGIGRYNFKPLYEGVLRRHPDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGC2</accession>
    <name>F4FGC2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19790"/>
    <dbReference type="EnsemblBacteria" id="AEB45060">
        <property type="protein sequence ID" value="AEB45060"/>
        <property type="gene ID" value="VAB18032_19790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19790"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_11"/>
    <dbReference type="OMA" id="YYGYGGF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="33866" checksum="94DDFBAB6FEB5D15" modified="2011-06-28" version="1">MEESELVLHAVRSQAGGMTPTGLYVPLITPFDARDEVDQEALTRLANRVLADGADGLVALGTTGEPHALSATEQRAVLDTLGAACRRHRAGFMVGAHTAEDLRALAGRPGVTAALCLVPPFLRPGEEAVLAHFARLAEVSPVPLVAYHVPYRTGQALSAGALRRLADLPQVVGVKHAVGGIDADTIALLADPAPDFAVLGGEDAYLSPLLALGAHGGIVASAHLATADYAALVAAWRDGDTTRARPLGHRLATLSAALFAEPNPSVIKAVLHAQGRIPTPTPRPPLLPATAQATAAALACAEQVAGPPALVRRPPLSVPTRGIRPGQGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGG0</accession>
    <name>F4FGG0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative monovalent cation/H+ antiporter subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_19980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733753.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19980"/>
    <dbReference type="EnsemblBacteria" id="AEB45098">
        <property type="protein sequence ID" value="AEB45098"/>
        <property type="gene ID" value="VAB18032_19980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19980"/>
    <dbReference type="eggNOG" id="COG1863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086615_0_1_11"/>
    <dbReference type="OMA" id="LIRIMGT"/>
    <dbReference type="OrthoDB" id="1987527at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="22083" checksum="8190A800544B57DD" modified="2011-06-28" version="1">MTPAEPTEPPNSAPLTPAARRRNRITAVIFLVVVWMLLWGTLSWANLISGLVVAAVLLAVFPLPPVTFAGRIHPLGTARFLLRFLSDLVVASVQIAWMALRPGHVPHSAIIAVRLRVNTDLNLTLAAEALSLVPGSLILEADRTTGTLFIHVINVDSLDEVEKFRRGVLKLEERIVAAIGSPDEQRRVRERPPPPLDLEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGQ9</accession>
    <name>F4FGQ9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736202.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02425"/>
    <dbReference type="EnsemblBacteria" id="AEB47569">
        <property type="protein sequence ID" value="AEB47569"/>
        <property type="gene ID" value="VAB18032_02425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02425"/>
    <dbReference type="eggNOG" id="ENOG5030CNA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142747_0_0_11"/>
    <dbReference type="OMA" id="HPAVKMW"/>
    <dbReference type="OrthoDB" id="1493219at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004260">
        <property type="entry name" value="Pyr-dimer_DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03013">
        <property type="entry name" value="Pyr_excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="159" mass="17928" checksum="14328C0EDEB3805E" modified="2011-06-28" version="1">MQTFLPYPDFLASARALDQRRLGKQRVEAIQVLRGLTRPDYGWRNHPAVKMWAGYEEALTRYGLDVCEVWCAAGRADTCAGTLSADLATACGIEQVRSQQELAVAGELPPWLGRADLHLSHRSSLIRKDPAHYRPIFGDDVPPDLEYVWPPSDRPRRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGS4</accession>
    <name>F4FGS4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736217.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02500"/>
    <dbReference type="EnsemblBacteria" id="AEB47584">
        <property type="protein sequence ID" value="AEB47584"/>
        <property type="gene ID" value="VAB18032_02500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02500"/>
    <dbReference type="eggNOG" id="COG1813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_1_11"/>
    <dbReference type="OMA" id="YAETHAQ"/>
    <dbReference type="OrthoDB" id="1478362at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="270" mass="30060" checksum="498FB6C267218426" modified="2011-06-28" version="1">MASGQLTAAAFLVAELRRARVRQGWSQEDLAKAVNYSPSMVSAVELGQQPPTPKYLEQFDKALDTGGLYGRMLTHLVALDKAQVWLRGWRAILEGADELRWFEPLHVPGLLQTEPYARAVFEADDSLARAEREERLADRLASQGVVCQEDPPRMVVVIDEAALRRRVGGRKIMLEQMQHLVRLANDHPSLRLLVVPQSADEYPGLNGPFMLATLKDRTVVAYLGGQIGGRELDRPSDLSMLQRVWEATLGAALPAQESIELLKEIAESWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGX2</accession>
    <name>F4FGX2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoD</name>
        <name evidence="8" type="ordered locus">VAB18032_02740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736264.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02740"/>
    <dbReference type="EnsemblBacteria" id="AEB47632">
        <property type="protein sequence ID" value="AEB47632"/>
        <property type="gene ID" value="VAB18032_02740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02740"/>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_11"/>
    <dbReference type="OMA" id="GGRMHYM"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="144"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="316"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="390" mass="42969" checksum="7AA02F70F5C6860C" modified="2011-06-28" version="1">MTTGDLRELTVGTGAGLVAGTGGEQLGTDMVLNIGPQHPSTHGVLRLKLTLDGERVVAAEPIVGYMHRGAEKLFEVRDYRQIIVLANRHDWLSAFANELGVVLAVERLMGMEVPERATWLRMALAELNRVLNHLMFLGSYPLEMGAITPMFYAFRERETLQAVMEEVSGGRIHYMFNRVGGLKEEVPSGWTGRARAAIGEVRRRMPDLDNLIRRNEIFLARTVGIGVLSAADAAAFGASGPVARASGLDLDLRRDEPYLAYDQLDVPVVTRTTGDCHARFEVLLDQVYASLDLAEQCLDRVDRLTGPINTRLPKVLKAPEGHTYAWTENPLGINGYYLVSRGEKTPWRLKLRTASYANVQALATLLPGCLVPDLIAILGSMFFVVGDIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH89</accession>
    <name>F4FH89_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13775"/>
    <dbReference type="EnsemblBacteria" id="AEB43867">
        <property type="protein sequence ID" value="AEB43867"/>
        <property type="gene ID" value="VAB18032_13775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13775"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2539155_0_0_11"/>
    <dbReference type="OMA" id="DLMGEVM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="71" mass="7777" checksum="431B0A4FF2535294" modified="2011-06-28" version="1">MGQVLANQGKVLPDDDGADLREIGFRSLDFSELALRVEDETDEELNFDAAGLRRIATVGDVLDFLADLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHE8</accession>
    <name>F4FHE8_MICM1</name>
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        <submittedName>
            <fullName evidence="1">PadR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20090"/>
    <dbReference type="EnsemblBacteria" id="AEB45120">
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        <property type="gene ID" value="VAB18032_20090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20090"/>
    <dbReference type="eggNOG" id="COG1695">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_0_1_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="133" mass="14373" checksum="CA43D39F6FDBA70D" modified="2011-06-28" version="1">MLRDGYIVEAAHQRVGGPDRVAYRLTPEGRTALDGWLSRAVPPAVHVSGELFVKVIVALLATPDEATARSYLAAQRAAHLARMRELTAVKTGGGASVTELAAADYLLNHLDADLRWMATTVDRIGQLRAEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHJ4</accession>
    <name>F4FHJ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20330"/>
    <dbReference type="EnsemblBacteria" id="AEB45166">
        <property type="protein sequence ID" value="AEB45166"/>
        <property type="gene ID" value="VAB18032_20330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20330"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_1_11"/>
    <dbReference type="OMA" id="IHEWPYL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="155"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="373" mass="38763" checksum="3739086CFB00E658" modified="2011-06-28" version="1">MRVGIDELYPPQRLVAAQRAIAAAGLDALLLSPGSDLRYLTGYDAHAGERLTLLVLPAEGEPTLIVPTLERPAAEASPAPATGVRIVDHTDGSDPYPLVTAALDGALDAVGLADRMWAEQVLALRAVLPGARQRLASEVLRELRIVKSPAEIAALAEAGAAIDAVHERMGEWLRPGRTEVEVAADIAAAIRAAGHVTIDFVIVAAGPNGASPHHGTSDRPIGVGEPVVVDIGGTMPSGYRSDCTRTYVAGGPAPAEFVDYYAVLRDAQHAAVAAVRPGVTAEAVDAAAREPIAAAGYGAAFLHRTGHGIGLDGHEEPYVVAGNDRPLVAGMAFSVEPGIYLAGRHGARIEDIVVCTTDGVRRLNTTTTELIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHU4</accession>
    <name>F4FHU4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine betaine/L-proline ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_02765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736269.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02765"/>
    <dbReference type="EnsemblBacteria" id="AEB47637">
        <property type="protein sequence ID" value="AEB47637"/>
        <property type="gene ID" value="VAB18032_02765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02765"/>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="MYEFNRA"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="331" mass="35497" checksum="5755F6BBDD02D713" modified="2011-06-28" version="1">MDGTPVADDGQRAASITLDGIGKRYPDGTEAVRDLSLHVDAGELVVLIGPSGCGKSTVLRMINRLIEPTSGRIMLGDADVTRTDPVRLRRQIGYVIQNVGLFPHQTVAANVATVPRLLGWSKDRARRRVDELLELVGLDPTQFGRRYPHELSGGQRQRVGVARALAADPVVLLMDEPFSAVDPIVRTRLQEEFLRLQAEVRKTIVLVTHDLDEAVRLGDRIAVLSEGGRLEQYDTPATLLGAPATPFVREFVGADRGIRRLVVTPVTREVLAPLPSDGVADLPAVALGGSAYDALAVLLTSAGGQAVVTEQGQPVGLLSRERVLALAEPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F136</accession>
    <name>F4F136_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative arginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731363.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07860"/>
    <dbReference type="EnsemblBacteria" id="AEB42690">
        <property type="protein sequence ID" value="AEB42690"/>
        <property type="gene ID" value="VAB18032_07860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07860"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_6_2_11"/>
    <dbReference type="OMA" id="RRTMILD"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="31251" checksum="D9F1AFCDC4774AE9" modified="2011-06-28" version="1">MRSITVLDAPSNLGLRAPAPGLVPGCYKLAGALRDQRLLDRLGAHDGGVVVPPRYDIRGWRPGDGVLNADALATYTRRLAERVNVVLDNAGFLMLLGGDCSILFGAALALRRRGRYGIAYLDGSIDFRHTGNSTYVGASAGEGTAIVTGRGQPDIADIDGLAPYCREDDLVVLGVRDYDDHLHEVRGLGITVHTAPEIIAEGPVLVGDRVAQGLARCDGYFVHLDADVLDPAVMPAADAPDPGGLDHPHLVELLRPLLANPACVGLEVTIYDPDLDPDGRYAAALVETLVDALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1F6</accession>
    <name>F4F1F6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="2" type="ordered locus">VAB18032_20425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007070998.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20425"/>
    <dbReference type="EnsemblBacteria" id="AEB45185">
        <property type="protein sequence ID" value="AEB45185"/>
        <property type="gene ID" value="VAB18032_20425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20425"/>
    <dbReference type="eggNOG" id="ENOG5031DSU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134276_0_0_11"/>
    <dbReference type="OMA" id="VWECRCG"/>
    <dbReference type="OrthoDB" id="1912152at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="13029" checksum="8B44971DB2AB4D00" modified="2011-06-28" version="1">MGERMLRGSRLGAVSYESDRNTELAPRQTREYLCAKGHQFEVPFAVDAEVPTTWECKFDGSVARLVDGTEPEQKKAKPPRTHWDMLLERRSIAELEDILAERLQEVRTRRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1G1</accession>
    <name>F4F1G1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_20450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20450"/>
    <dbReference type="EnsemblBacteria" id="AEB45190">
        <property type="protein sequence ID" value="AEB45190"/>
        <property type="gene ID" value="VAB18032_20450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20450"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012430_1_1_11"/>
    <dbReference type="OMA" id="PPRATQY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="15"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="401"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="11">
        <location>
            <begin position="612"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="668" mass="72603" checksum="9894250814EF79B0" modified="2011-06-28" version="1">MGGMFNDGRLCFGGDYNPEQWPASVWAEDVALMRRAGVNLVTVGVFAWSRLEPAPGRYTFDWLDEVLDLLHAGGIRVALATPTASPPPWFSAAHPGALPVTADGVRLHHGSRDTYCAAAPAYRTAARGIAGALADRYAHHPALALWRVHNEYGTICHCEHTARAFRRWLADRHGDLAALNDAWVTSFWSQHYSDWTQISTPRATQYLANPGQLLDFRRFWSDTLLAAYREQRDLLRAANPSIPVTTNYVLGDWVPVDHARWAGEVDVVAVDHYPSAVDIGAEEQTALVGDLARGWARHGSRHHGDPTSTWLLMESAPQQIHTTGRAHTKEPGRMIRHSLAHVARGSQGAMFFQWRAPTGGAERFHSALVPHAGPDSRVFREATDLGTALHRLAEVDGQVEAGVALAVDAASGWALRHPGMPSDRLDHQQETAAAHRALWHAGYGCDIVLPGDPLTGYRLLVLPALYLTDDDTAQWVGEYVTGGGHLLATYLSGVADEHARVRLGGYPGALRDLLGVRVEEFHPLAADDQVRLSDGGTGRIWAETLRPTGAQVITAYAGGVLDGQPAITRHRAGSGTAWYVSTRPDDATYRRLLDEAARSAGLTPVCPDAPAGVEAVRRRAAHGSWLFLFNHTDTPQRVPARGTDLLTATAVDEAVQLPPGGVAVLREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1I3</accession>
    <name>F4F1I3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733866.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20560"/>
    <dbReference type="EnsemblBacteria" id="AEB45212">
        <property type="protein sequence ID" value="AEB45212"/>
        <property type="gene ID" value="VAB18032_20560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20560"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_6_11"/>
    <dbReference type="OMA" id="YRMFECD"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="27764" checksum="B1036D83700214E1" modified="2011-06-28" version="1">MPPRSRYLDGSTPLAFAHRGGAADGDENTTAAFARAIDLGYRYVETDVHATADGVAVVFHDDTLQRVTGTPGRVADLRWADLAAVRVGGAAAVPRLDEVLDAWPQVRFNIDVKSDRAVVPTVATVTRAGAGDRVLLASFSDSRLSRLRALTGEQVATSLGVRGVARLRWASLTGRRLRLPPSVVAAQVPVRYGRLPLVDRRFLRTAHRLGLQVHVWTIDEPAEMHELLDLGVDGIMTDHVGVLRDVYRSRGHWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1K3</accession>
    <name>F4F1K3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20660"/>
    <dbReference type="EnsemblBacteria" id="AEB45232">
        <property type="protein sequence ID" value="AEB45232"/>
        <property type="gene ID" value="VAB18032_20660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20660"/>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_0_0_11"/>
    <dbReference type="OMA" id="RHGDMVR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="288" mass="29747" checksum="B8BF95A36268DA85" modified="2011-06-28" version="1">MTTTSTTAATSPVTGTQALLAAVGAGVRTYDLGRRLTIGMPQSPNHPPFWHALPRRHGDNVRADGGSAANDIITMGTHVGTHIDAFAHVSQDGRLVDGSDAAVAGRGGRFAELGAHTIAPMVRRGVLLDVPAALGQPDGCPPGYEITPQDLSAAAQRQGTPIRPGDVVLIRSGWGRLFDHEDRTRYVGHASGVPGVGAAGATWLADAGAHAVGADTIAFECLRPGAGHSVLPAHRVLLVERGVYIIETMALEELAADAVHEFLFVLSPLAIFGATGSPVRPLAVIANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1R4</accession>
    <name>F4F1R4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735140.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27081"/>
    <dbReference type="EnsemblBacteria" id="AEB46489">
        <property type="protein sequence ID" value="AEB46489"/>
        <property type="gene ID" value="VAB18032_27081"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27081"/>
    <dbReference type="eggNOG" id="ENOG5033FW7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066404_0_0_11"/>
    <dbReference type="OMA" id="MTWWLTT"/>
    <dbReference type="OrthoDB" id="1587142at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="29566" checksum="E60859D54F7CBCAA" modified="2011-06-28" version="1">MSAGGARRGRRDNGIDANEYAVAGDVDPRVGEHLLDVLAAGGIAAYLQPSADLNPVTRTTTVPPRPVDRLYVDRSHLSTARDYLNQLSDEGTSERVNEEPDIDAEWAQIVAGFNASPAAGAHPWPAAEDVDEPPGRAGTTTTATLPSPDEPAGPTATGVRRLPYAADISGVSVGRGPRDGDGPSLLDGLDTFGADLPDDPDADERYVPPPPPPLPRVSKFAVAGVLAVLLGFVLFLFPDLVPADRGVVTLLGFTGILAGFVTLVWRLRPGDEERDPDDGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1W4</accession>
    <name>F4F1W4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27331"/>
    <dbReference type="EnsemblBacteria" id="AEB46539">
        <property type="protein sequence ID" value="AEB46539"/>
        <property type="gene ID" value="VAB18032_27331"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27331"/>
    <dbReference type="HOGENOM" id="CLU_990265_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="25408" checksum="1BAF5994162AFC1C" modified="2011-06-28" version="1">MSGGVESGLVVAGGVESRLVVSGGVESRPVGIGDVRSGLVAGGVESGPAVAGDAESGVDVIGGAGIGGAGCGEVGGADTGTAVGVGVDGRAASGVGMAGEAASCGAEGSRAGSAVAGERVSGVDVTGGAETGVCHGGADVGSAGGAETGACRGGAGVGSAGGAETGRAVGGGAVVPWLGGAEVGERADVWRDVAARGDTGSGSLAIDGAETGRVSSVSSGQLTGSDPPTAVALPGDSSNRVGVTCSRPEVGAGLGAGDPNHACGPSDGGPTRVEVCGTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F228</accession>
    <name>F4F228_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03455"/>
    <dbReference type="EnsemblBacteria" id="AEB47775">
        <property type="protein sequence ID" value="AEB47775"/>
        <property type="gene ID" value="VAB18032_03455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03455"/>
    <dbReference type="eggNOG" id="ENOG5033055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168335_1_0_11"/>
    <dbReference type="OMA" id="CVFILES"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="92" mass="10219" checksum="DBDDE79067A18EE4" modified="2011-06-28" version="1">MVPLAYSPTMVLSRSWAIFLTGVGVWTWVIWPRFALAIWNDPRSWTSGKVGDWPATGFLWVHALLIGASLAIGTTVGLLGVRAWRAARRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2A0</accession>
    <name>F4F2A0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08355"/>
    <dbReference type="EnsemblBacteria" id="AEB42789">
        <property type="protein sequence ID" value="AEB42789"/>
        <property type="gene ID" value="VAB18032_08355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08355"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_11"/>
    <dbReference type="OMA" id="LALQYPK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="265" mass="27643" checksum="0F8E401B9AFE700E" modified="2011-06-28" version="1">MIPAGYDSAPLRCNGATDRRATIGVMSDTKTALVTGANKGLGYEIAAGLGARGYRVVVGARDRARGEAAVAKLLAAGVDAFAVPLDVTSDRSVAEAAALIDRLDVLVNNAGISGETGPGWVQDPTMLDLDVVRAVVDTNVYGVIRVTNAMLPLLRRSASPRIVNISSSVGSLTWQSDPTIDVGPIMAAYSPTKSFLNAITVHYARQFAGTKILINAACPGLVATDFTGFHGRPPQEAAATPIRLATLPDNGPTGRFFNDTGPIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2B6</accession>
    <name>F4F2B6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="7">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmI</name>
        <name evidence="9" type="ordered locus">VAB18032_08435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08435"/>
    <dbReference type="EnsemblBacteria" id="AEB42805">
        <property type="protein sequence ID" value="AEB42805"/>
        <property type="gene ID" value="VAB18032_08435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08435"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_0_0_11"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="29888" checksum="84A6727204E37982" modified="2011-06-28" version="1">MSDLGRLILLGAPLGNPADASARLRDVLATADVVAAEDTRRLGRLARDLDVTVAGRIISYFEGNEERRTPELVDELTAGRVVALVTDGGMPSVSDPGYRLVRAALEAGIPVTAAPGPSAVTTALALSGLPSDRFCFEGFLPRSPSGRRSRLRALADEERTLVIFEAPHRITAALADLADTFGADRPAALCRELTKTYEEVVRRPLGELARWAADGDPRGEITLVVAGAPTTPATRPDDDTLRAAVADREAAGLTRRDAITEVASTFGLRRRDVYTVVHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2R0</accession>
    <name>F4F2R0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lantibiotic dehydratase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21125"/>
    <dbReference type="EnsemblBacteria" id="AEB45325">
        <property type="protein sequence ID" value="AEB45325"/>
        <property type="gene ID" value="VAB18032_21125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21125"/>
    <dbReference type="eggNOG" id="ENOG502Z8P5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013885_0_0_11"/>
    <dbReference type="OMA" id="WEWIRAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="2">
        <location>
            <begin position="169"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="944" mass="104752" checksum="697B3BB7ABF8A780" modified="2011-06-28" version="1">MTPPTHTDTPTKEMPVTVSLPAPPATEMSWLMPEVFMLRTGGLPLEVADRLAFDRSAAWANQVVDLETRLRDTGRDLADTLQAVVARHLHDDGLRQRLIRLRRDVYNLRRPRPADPDAWADVLDADTHRALTDWLQTFDAYRRGLADGPAVLAEELTERRAVLRDLADDPDLRGGILLASPSLDQYLPGYLATPGRPGKRTRRVERSLLEYALRTACKTSPFSRLTTVNVGTFSHGGGRLLDVRPATGAGKTAVARLNLAALGRLSAIVLADETLRADLPVTVTTGWRIERGRLRYLRRRRTSSEDGDAAITLESIHESLFVLPTGQVLHDILAALDGGRVRRLSELAAELAVDGRPADEVGQYLHHLLRVGLLVVPNLQLDIHADDPVEGYRRALRDIDRPWADRLADRVASVNRLATDYPDADVDGRRAALAQIRQELLAAHTDLGRADIPAPRTLVYEDATLRTDAPVTADRDRWDRTVLPGLRALARIMPVFDVNLPRRVVTKGFFLARYGVGGRCDDLLSFAHEFQQDFFEHYTGRSMRRRAFDADNTYVRQENWFRQDEITALDDARIEVARRVNEAYAALPADAEEMMLDETFMAEVAAMVPDTLGTLDPRSFFLQLADQGDRQRVVVNRVYSGMTLLFSRFAHLFAAEDLAGALRAELARLQPPGAVLAELRGGYDATNLNLHPAVTPYELVCPGEISFRPTAEQIHMDDLSVEHDPVADRLLLRSRRLDAEVIPVYLGFLLPMALPEVQQVLLNFAHLGMAQPDLWAGTTVPLPEGGMVGYPRIVHGDLVLQRRMWKLHPGHLPPARTPQVDDAEWFLAWQRWRRENGLPRRVFATPEGTRLVPAADDGEAPAGGGAAGGGAAGGRPEHKPLYVDFDSYLCLQLLEATGRSAGSRLVLVEMLPDRDEQVVRGASGSYVTELTVELNGVRGGVDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2X4</accession>
    <name>F4F2X4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27561"/>
    <dbReference type="EnsemblBacteria" id="AEB46585">
        <property type="protein sequence ID" value="AEB46585"/>
        <property type="gene ID" value="VAB18032_27561"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27561"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074146_0_0_11"/>
    <dbReference type="OMA" id="FWYGLDR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="270" mass="28915" checksum="80839ABEC9E1916B" modified="2011-06-28" version="1">MSLRMDEPLRRYLATLVAVAGEVLGDRLCGAYAAGSVGLAAYQPGRSDVDVALVCADRLDRAVASELVARLRHEALPCPARGLELVVYRREVARSGTGEPGFEVELNTGAGMDFRVSYTPADRPAADGLFWYGLDRSILHQSGRALFGPPAAEAFADLAPSDLRRLVRDALRWWLDRPVPPGGQPAPGAEDAVLGACRSWVRLRHGVWLPKVAAGRRLLDEAGPLVDADTVDLVEQSIAARTGGTPPTGPRARGFQRRVLAALGDEDGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F393</accession>
    <name>F4F393_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stearoyl-CoA 9-desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_08495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731488.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08495"/>
    <dbReference type="EnsemblBacteria" id="AEB42817">
        <property type="protein sequence ID" value="AEB42817"/>
        <property type="gene ID" value="VAB18032_08495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08495"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_1_1_11"/>
    <dbReference type="OMA" id="SCGESWH"/>
    <dbReference type="OrthoDB" id="797871at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="65"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="317" mass="35120" checksum="66584986115B1614" modified="2011-06-28" version="1">MSTALLDPGPKPLTQGAQSRGILVALWAFVVIPFAALVAAVPVAWGGWLGWVDVGVAAFWYVVSGLGITVGYHRYFTHGSFKAKRGLRVGLAVSGSLAVQGDIIQWVADHRRHHAFSDLEGDPHSPWRFGPTLWGLTKGLFHAHVGWLFGRELSNRERFAPDLLNDRDIRRVSGLFPVLVIVSVLGPALMGGLLTWSWQGALTALFWGGLVRISLLHHVTWSINSVCHVYGERPFMMRHGDRASNFWPLALLSFGESWHNLHHADPTSARHGVLRGQIDISARVIWLFEKVGAAWDVRWPKPERLAAKLVKPTDQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3D4</accession>
    <name>F4F3D4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_08700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731529.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08700"/>
    <dbReference type="EnsemblBacteria" id="AEB42858">
        <property type="protein sequence ID" value="AEB42858"/>
        <property type="gene ID" value="VAB18032_08700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08700"/>
    <dbReference type="eggNOG" id="COG4988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_11"/>
    <dbReference type="OMA" id="EYFLPFR"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042883">
        <property type="term" value="P:cysteine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014216">
        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02857">
        <property type="entry name" value="CydD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="333"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="365"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="556" mass="58208" checksum="CF9CF314E215BDC8" modified="2011-06-28" version="1">MNRRPFDPRLLRRVPAARGDLALLGLLGVLAAGLVVAQATALATLLASAFTGELNRPALAGFVAAVAARSVLVWAQGTVSARLAATVKAALRADLLGAVARHGPGWVAGQRAGQLATLAGRGLDALDAYFTGYLPQLVLSVTVPVAVLGRIVFADWSSALIIALTLPLIPIFGALLGWQAQAATERQWRRLSRLGGHFLDMVAGLPTLRAFGRAKAQTDAVRRMADSHRVATMKTLRIAFLSALVLELVATLSVALVAVPVGIRLLGGGLTLQVALLVLLLTPEAYLPLRAAGSRFHASMEGLTALDEAFTLTGAAPAPQTRAGALPDGRGEIRFESVTVAYQRTVALRDVSLTIRPGERIAIIGPSGAGKSTLLGLLLGFVTPTRGRVTVGGVDLAEADLDGWRRQVAWVPQRAHLFAASLADNIRLGVPEAAPTAVEKAVQDAALDDVIAALPDGLDTMLGERGHGLSSGQRQRVALARAFLRDAPVVLLDEPTARLDTAAEAAVLTATHRLVAGRTALLVAHRPALLADADRILRVDDGRVTELTPQPTGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3G6</accession>
    <name>F4F3G6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732741.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14810"/>
    <dbReference type="EnsemblBacteria" id="AEB44074">
        <property type="protein sequence ID" value="AEB44074"/>
        <property type="gene ID" value="VAB18032_14810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14810"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090621_0_0_11"/>
    <dbReference type="OMA" id="LGMYADN"/>
    <dbReference type="OrthoDB" id="1270792at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="122"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="26404" checksum="0E97EA47BCC3EF80" modified="2011-06-28" version="1">MVIADGALAEREAILSAMDQHPFVRHSLPTRETFRVWRGDGTLGWLLPAATLGPLGGVFGPPAEALELFGALTAQGVFQPGRWVHLPRLASEALDAVPSVTGHEDWDFLWTTTPPPRQPGEERVVRLSEADHPALTALIDESFPTSTARPGNPQVVDWYGIREGDRLIACGADRTRGDVGFLAGLTVAPAFRGRGLGAALTAGMSRALAAHHDTLALGVYPANIGAIRLYRRLGYTAAFPLTSVRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3H8</accession>
    <name>F4F3H8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_14870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732753.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14870"/>
    <dbReference type="EnsemblBacteria" id="AEB44086">
        <property type="protein sequence ID" value="AEB44086"/>
        <property type="gene ID" value="VAB18032_14870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14870"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640435_0_0_11"/>
    <dbReference type="OMA" id="QSHMHQG"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="5">
        <location>
            <begin position="65"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="418" mass="46083" checksum="5F0348394CC4B900" modified="2011-06-28" version="1">MSDSSLRHRIGKTTLTLRGPDRRALAEQVVTLAQRRHAFAFGNIGFDFVNLVGGPDPENAQPFGGTDSADLDRLGDLWLGLFNTATLPFYWGSYEPRRGAPDTERLTRTARWLADHGVTVKGHPLVWHTVQPPWLLGLDLDEVEALQRARIRDLVGGFAGLIDTWDAINEAVIMPVFANGDNAITDLARARGRIHMVRMAFEEARAANPTATLVLNDFDLSSAYECLIEGVLEAGVGIDAIGLQTHMHQGYRGEEYMHEMLDRFARYGLPLHLTETTLVSGHLMPAEIEDLNDYQIPQWPSTSEGEARQAEEIVRHYRSLLAHPAVESVNYWGLTDRGAWLGAPAGLVRADGSRKPAYDALEALIKGEWWLPPTPMRTDADGRVTVEGFLGDYTVSAGEHRAHFTLDAADSAATISVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3J1</accession>
    <name>F4F3J1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="10" type="ordered locus">VAB18032_14935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14935"/>
    <dbReference type="EnsemblBacteria" id="AEB44099">
        <property type="protein sequence ID" value="AEB44099"/>
        <property type="gene ID" value="VAB18032_14935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14935"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_2_0_11"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="317"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB44099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="41536" checksum="53B92EAD4C85C3DB" modified="2011-06-28" version="1">MAVLRWLTAGESHGPALVALLEGVPAGIEVTTTEIAGELARRRLGYGRGARMSFEQDEIEVIGGLRHGVTLGSPVALRVGNSEWPKWRTVMAADPVDADELARQARNAPLTRPRPGHADLAGMQKYGHTDARPILERASARETAARVAVGTVAKALLRQALDVEIVSHVVELGPVAVKPGLRPRPEDAERIDADPLRCLDPEASARMVAEVDAAKKAADTLGGVVEVLAYGVPPGLGSHVQWDRKLDARLATALMSIQAIKGVEIGDGWQQARSRGSEAHDEIIPTATGVRRVTDRAGGLEGGITTGEPLRVKAAMKPISSLNRALATVDITTGEPATAINQRSDVCAVPAAAVVAEAMVALVLAEAAVEKFGGDSIAEMRRNLAGYLDALVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3M5</accession>
    <name>F4F3M5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44133">
        <property type="protein sequence ID" value="AEB44133"/>
        <property type="gene ID" value="VAB18032_15105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15105"/>
    <dbReference type="HOGENOM" id="CLU_3334354_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="38" mass="3927" checksum="F72B955489FFA48E" modified="2011-06-28" version="1">MTGACGRSVTAEVSRWRTARTTTAASVPIPSTYAEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Z1</accession>
    <name>F4F3Z1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735287.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27821"/>
    <dbReference type="EnsemblBacteria" id="AEB46637">
        <property type="protein sequence ID" value="AEB46637"/>
        <property type="gene ID" value="VAB18032_27821"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27821"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_6_1_11"/>
    <dbReference type="OMA" id="SEQMIND"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="32764" checksum="D4D3DACE2BEA101E" modified="2011-06-28" version="1">MPEQVEVRLPDDVRLHVEARGPADAEVTVVLLHGWTLDGRSWHRQVAALRETYPSVRVVTYDARGHGRSSCMALPTATLAQLGDDLAAVLDTVSSGGGRVVLVGHSMGGMTIMEYAHRHPEHFARRTAGLLFVSTTAEGHTHTVYGLSPRIARIIRLAETTGAGVLARCGSWRPPRALLRALQPSIRWMLFGERCDPADIRLVTSAVARASLRSIGGFRASIGAQHRLETLAALAHLPAAALVGDRDRLTPPPCAESIAEALPATDLVVCPGAGHMLMMERAEEVNGALSGVLRRVLDTSPVRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F416</accession>
    <name>F4F416_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735312.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27946"/>
    <dbReference type="EnsemblBacteria" id="AEB46662">
        <property type="protein sequence ID" value="AEB46662"/>
        <property type="gene ID" value="VAB18032_27946"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27946"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_6_2_11"/>
    <dbReference type="OMA" id="MTAGTFR"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="309" mass="33718" checksum="CAAFB46B9FED0829" modified="2011-06-28" version="1">MELRIFTEPQQGATYDDLLAVARRAEETGFGAFFRSDHYLKMGSVSGDPGPTDAWTTLAGLARDTRSIRLGTLMTAATFRLPGPLAITVAQVDQMSGGRVELGIGTGWYDAEHSAYGIPFPALGERFDRLAEQLAIITGMWRTPAGQTFDYTGRHYQVSDSPALPKPVQRPHPPILLGGMGAKRTPQLAARYADEFNLPFVSIADTVTQFERVRAACQRIDRDPTELVWSNALVLCCGKDDAEVARRAAAIGREPDELRENGVAGTPAEVVDKIGQYAAVGSQRIYLQVLDLSDLDHLDLVAGEVMRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F468</accession>
    <name>F4F468_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736513.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03995"/>
    <dbReference type="EnsemblBacteria" id="AEB47881">
        <property type="protein sequence ID" value="AEB47881"/>
        <property type="gene ID" value="VAB18032_03995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03995"/>
    <dbReference type="eggNOG" id="ENOG502Z89R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025319_1_0_11"/>
    <dbReference type="OMA" id="GWAVMPL"/>
    <dbReference type="OrthoDB" id="1885417at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="563" mass="58689" checksum="C4A608AA5365F07D" modified="2011-06-28" version="1">MAVPVTDPASRVHPVKARHFVRLKLRVIGNNFRGQAWRAVLFVIGSLVGLWLAATAFFGLAAPGFAGEDRYALLVAAFAGGLTVLGWLLLPLVFFGVDETLDPARFALLPLSRRTLVTGLFAAALVSVPTVAVLVALSGLVVTAGVFGGWPAAAVAVLGVISGLLLCVAAARAMTSAFASMLRSRRVRDLAAVLLAVAAALLGPLQLAGLAAIRDTDWDRLTGVATVIGWTPFGAPWTAGIDVAQGRAWAAPLKLLITVVTIVALLAWWSRSLESAMIGTASTGPSKGKPEVSGGAVDQLFPQAAGWLRRDRFGALVAREARYWWRDARRRANLITIAVVGLFVPVMVNVGGQGFSIDSEQGFSLPSDTSPLLVSLSMLFVGLLAAMTLANQFGFDGSAYAANVIAGVPGRLELRARMVAFSLYVLPMLVLVSVVMALILGEPTWVGFMAGTLIATFGAGLAVNSFVSVLAAYSLPETSNPFAMNSGAGVTKSLLALVAMVATAATGLPTVIAAALLGDAWLWLGLPLGILYGVGVALLGSYLAGDALDRRQPELLTAVTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F485</accession>
    <name>F4F485_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04080"/>
    <dbReference type="EnsemblBacteria" id="AEB47898">
        <property type="protein sequence ID" value="AEB47898"/>
        <property type="gene ID" value="VAB18032_04080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04080"/>
    <dbReference type="eggNOG" id="ENOG5031QN4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108064_0_0_11"/>
    <dbReference type="OMA" id="IRTLACD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="223" mass="22394" checksum="EC298DF37FF739F7" modified="2011-06-28" version="1">MPPSPLRRAAAGRRPARPDPRPRVGWAAGVLALTGLLLSGCGEPPEVRDGGTSGLPTTTATPSPSGPVTPSPSVAVPPVAGTAVPTTDAGLVATACRGEPSGQGVVNLVRGRSGLLPRNAKVKVSEGPLCAADWHFTALDVTGYEPLHVVTRRQAGALRLVTAGTDVCSVEVRVTAPPGVRRLACGDDAPVTVPLPTQFPTTPTPLPTTPAATPSTTTPGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4K7</accession>
    <name>F4F4K7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_09235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09235"/>
    <dbReference type="EnsemblBacteria" id="AEB42965">
        <property type="protein sequence ID" value="AEB42965"/>
        <property type="gene ID" value="VAB18032_09235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09235"/>
    <dbReference type="eggNOG" id="ENOG50331S3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093434_0_0_11"/>
    <dbReference type="OMA" id="VIACWVR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313589" description="DUF4129 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="151"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="242" mass="25760" checksum="2989C31E9E48ED41" modified="2011-06-28" version="1">MDFVRRWWSVAVVAALLAAVALAATHSSIGASRIPPAVQDAPFVLEYPTGDPRPSIPAEPRQAAEQASTALPAWLGTVAVVLLGMALLAALSYLGWSVMRSVARRVTRRLPVGVTRRNAEGTAREVVAAVDAGLVELDDRSTDPRTAVIACWVRLEEAAAAAGVPRLTGDTPTDLVTRLLRGDPSAGVPAIVSADVLAEFANVYREARYATRPVDEHTRDQARAALRRLRGELAATVEQVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4M9</accession>
    <name>F4F4M9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Atpase, P-type (Transporting), had superfamily, subfamily ic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_15295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15295"/>
    <dbReference type="EnsemblBacteria" id="AEB44171">
        <property type="protein sequence ID" value="AEB44171"/>
        <property type="gene ID" value="VAB18032_15295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15295"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_11"/>
    <dbReference type="OMA" id="FGIDDYI"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="790"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB44171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="863" mass="89051" checksum="C819FD65D33002B3" modified="2011-06-28" version="1">MSTDIVTRPVAVNGLSSAEAAERLRLDGPNAAEAPPRRHLTVRVLRQLTDPLVALLLAAAVVTTVLRDYPDTAVILLVVAVNTVIGVVQEVRAERAIAALDQLAAPTARVVRDGRDLVLPAADLVRGDLVRVEAGDVVPADLLLDEASRLRLDESALTGESLPVARDVGEEASAGTVVTVGRATGTVVRTGAASALGRIATLAATTRPGPTPLQRRLSALGRVLGLVAVLLSGLVFVVGVLGGRPLVDMAVTAVSLVVAAVPESLPAVVTLALALGARRMAQARAIPRRLHAVETLGSVTVIASDKTGTLTEGRMAVQHARTADGAGFDVTGTGYAPHGAIHRDGQRIAVTDELRQLARAGLLCNDATLTPPDDQRPEWGAVGDPLEGALLAFAARCGLDPQATRRAWPRVAEHPFDQELRRMTTVHRCCDNRYLVVCKGAPESVLAAPLVDADAEELAELAAAAQEMAGAGLRVLALAAALVDTPPVDPAHPVGLRAVGLVGVGDPLRAGAPEIAGSFTEAGVRLVLVTGDHPATAAAIAGQLGVWDTGDPVVRGDDGDPAEADPAARVFARTRPEQKLDIVAAMQARGHVVAMTGDGVNDAPALRRADIGVAMGGGTEVARQAADLVLVDDDLSTVATAIGEGRRIYDNIRRFLRYALSGGVAEIVVMLLGPLFGLAVPLLPAQILWINLLTHGLPGVALGAEPAEPGTLRRVPRSPQESVLGAGLGRHILIAGALISAVTLGAGVLAAHWDRPWQSVVFVVLGLAQLGVALAVRAPRPPDGRRGNPALPLAVAISALLQVAGVLVAPLRDLLGTEALGAVELLACAAVSVLPGLLLRLTMMIRRRKAGSVNLTSPDGSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4W9</accession>
    <name>F4F4W9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_21790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21790"/>
    <dbReference type="EnsemblBacteria" id="AEB45458">
        <property type="protein sequence ID" value="AEB45458"/>
        <property type="gene ID" value="VAB18032_21790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21790"/>
    <dbReference type="eggNOG" id="COG2746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936724_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="32094" checksum="0A99D8FFD55CEA1D" modified="2011-06-28" version="1">MSTPYTRPDRSETHMIFEEHLATALAGLHLTERPVMLHTSLRSFRTVIDGGADAILDALLNRGCTVMVPAFTEPQFAVAAPTDMRPARNGVDYAAPPVEDTLLEPSPYRVDCGLINPALGLLPAVLVGRPDAVRGRHPLNSFAAVGPEAAHIIDAQSPDDVYGPIRELADRDGVILLIGVGLNRMTALHLAEQWSGRRMFRRWAKDIDGAVRMVEVGSCSAGFPKLEPVLGSLDQNIMVGASRWRAFPARQTLAAATAAIAAQQDITRCPDTECMLCRDAVAGGPTTCHTRRPAFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4X7</accession>
    <name>F4F4X7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734119.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21830"/>
    <dbReference type="EnsemblBacteria" id="AEB45466">
        <property type="protein sequence ID" value="AEB45466"/>
        <property type="gene ID" value="VAB18032_21830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21830"/>
    <dbReference type="eggNOG" id="COG3864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038906_0_0_11"/>
    <dbReference type="OMA" id="AGVWVHE"/>
    <dbReference type="OrthoDB" id="801007at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="1">
        <location>
            <begin position="274"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="416" mass="45295" checksum="B403B259973F2DC6" modified="2011-06-28" version="1">MSTGQAGTLDRDKLFTARLHAARVRPYLATALFALHVVESRWVPTMAVDPHWRCYVSPRFVDRTPVEELAGVWVHEVSHLLRDHHGRSDRVAREQGLTGPGERLRMNIAADCEINDDIFGDGLARPEGAVEPGDLLLPAGQLMEAYLRQFRLGPRLQHLAWLDCGSGADGLHRQWDLGPDGAHALSPQERDAVRFRVAEGITGRPGNVPQGWRRWAERAFHPPQPWRELLGAAVRSAVSAPGVGEDYTYGRPSRRSAGTPGVVLPALRRRPPRVCVVIDTSGSVSDAELGSALLEVAAISRAVGGRRDLVSVLPCDAAPQVVRATCQAEDIPLIGGGGTDLRAGFARALRDRPGPDVIVVLTDGQTPWPTSRPPCRTVVGLFPRARRWDEDDPDHVPDSPPQWARVVTIGSAPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Y9</accession>
    <name>F4F4Y9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="12" type="ordered locus">VAB18032_21890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734131.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21890"/>
    <dbReference type="EnsemblBacteria" id="AEB45478">
        <property type="protein sequence ID" value="AEB45478"/>
        <property type="gene ID" value="VAB18032_21890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21890"/>
    <dbReference type="eggNOG" id="COG2156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077094_0_0_11"/>
    <dbReference type="OMA" id="KYFWPRP"/>
    <dbReference type="OrthoDB" id="1912405at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB45478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="293" mass="30241" checksum="B1CD30AD9D6A0E40" modified="2011-06-28" version="1">MRLPTWLAHHLAALRALLVFTALAGIAYPLTMVAVGRLPGLTDRADGSIIEVDGHAAGSALIGQSFTDADGKAVPRYFQSRPSAAGDGYDPTSTGATNLGPEDVVDVIATDPDESRQSLLTQVCARSRAVGELDGVDGRRPYCTTDGVGAVLAVFRADGLTGPVLRVVSVNQTAPATPFLPGYAGVPVELAQPGQDYRAAGATIVPVRGDAPAVPAVPADAVTASGSGLDPHISPAYARLQVPRVARERGADPAAVERLVDEHTTGRTLGFMGAPGVNVLELNLALDETFPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F571</accession>
    <name>F4F571_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4240 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735403.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28411"/>
    <dbReference type="EnsemblBacteria" id="AEB46753">
        <property type="protein sequence ID" value="AEB46753"/>
        <property type="gene ID" value="VAB18032_28411"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28411"/>
    <dbReference type="eggNOG" id="COG3831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085061_2_2_11"/>
    <dbReference type="OMA" id="RWDVWAA"/>
    <dbReference type="OrthoDB" id="2016600at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025334">
        <property type="entry name" value="DUF4240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14024">
        <property type="entry name" value="DUF4240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4240" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="177" mass="19750" checksum="F107B74173BBFBA6" modified="2011-06-28" version="1">MRTDEFWQLIDSARSGGGEPDAIAARAVALLAARDPEEIIGYARHQRRVLTASYRVDLWGAAYLINGGASDDGFEYFRGWLMTQGREVFARAVAGPDSLADLPRVRSASLSGEEFECEDMLAVPWDAYRKATATELPTDRESPPVPDLNDFWDFDDADEARRRLPKLAALFVEPPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5A9</accession>
    <name>F4F5A9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane protein MviN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_04375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736588.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04375"/>
    <dbReference type="EnsemblBacteria" id="AEB47957">
        <property type="protein sequence ID" value="AEB47957"/>
        <property type="gene ID" value="VAB18032_04375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04375"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_3_0_11"/>
    <dbReference type="OMA" id="KIFWPSA"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="581" mass="60377" checksum="D1E7D2BCEC638223" modified="2011-06-28" version="1">MSGGLYRSANAQQGGAPGGRPGDGATFISADPLNQPAAESVAPPQEQVAESSAATNSAVMAIGSLVSRGTGFLRTLAITAALGSAIGDAYTTAQILPGMVYEFLLGGILTSVLIPVLVRRRKFDQDGGQAYTQRLLTLAVVALGAAALLAVAMAPVLTWLYASDEAPADYRSLVTSLARLMLPMIFFTGLSALISAVLNTRGHFAAPMWAPILNNIVVIATAGLYIAIFSTDILAPDEMTTGRILLIGGGTLLGVAIQAAGLLPALRKVGFRWRFRFDFRALGLGELGRLGAWMFCYVAVSQVGLIVVFNLLSRTSGQAAGALIYNNVFLLLMMAHGIIAVSIITALMPRMSAAAADGRYADLAADLSRGTRTVSAVLAPIAVCYAVLATPIAFTLFRWGAFTDEGAKATAPVLLFAAVALVPFAVSQLFTFAFYALPDTRTPALINIPVVALRALVQIGLFAAFSASFAASGMMIGNTISYLAAAIASAWLLRPRVGRIGLGTILRTLGRVAVAALGAALVGLLVVAVLPGDDTPTRLQALVQLVVGGAVIGGAYLGLAMLLRISEITEVVGMVRRRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5K7</accession>
    <name>F4F5K7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731710.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09605"/>
    <dbReference type="EnsemblBacteria" id="AEB43039">
        <property type="protein sequence ID" value="AEB43039"/>
        <property type="gene ID" value="VAB18032_09605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09605"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119649_0_0_11"/>
    <dbReference type="OMA" id="CAGSVTF"/>
    <dbReference type="OrthoDB" id="1656811at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312710" evidence="2">
        <location>
            <begin position="31"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="224" mass="23012" checksum="AAB0C61EB32F4F58" modified="2011-06-28" version="1">MKVQRKHMLAAGVAVMAAGALAVSTGLGFADSTPTAQSVCPGSITFSAEGGAPAATSNQFPVGTRLRVTNLDNARTAEVTVVGPSGSCVLLNSAAMDLVREPGKNVIRRNVVERLGGVAVPPRQPGQVADRPGVASPPAVRPVDGSACQGAITFFEEAAAPAATSDRFPVGTRLRVTNLDNNRSTTVTVTGPSGSCVLLNSAAMEQIREPGKNLVRNNTVELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5W1</accession>
    <name>F4F5W1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22100"/>
    <dbReference type="EnsemblBacteria" id="AEB45520">
        <property type="protein sequence ID" value="AEB45520"/>
        <property type="gene ID" value="VAB18032_22100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22100"/>
    <dbReference type="eggNOG" id="COG3214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047003_0_0_11"/>
    <dbReference type="OMA" id="MWPRWRQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="341" mass="37530" checksum="4322192476293FBE" modified="2011-06-28" version="1">MSAAEWSLGARLDEVSRQSVQDALWRDHRLVKTRGPRGTVHLLAADDLPMWAGALGALPTGQDHQPAAVRMTKLQVEAVIEAIDDALRDADLTVDELTVAIAARVGDWSADRVMEAFGDRWPRWRQIEHQVTNRGVMCFGPLRGRKVTYTSPARLLPGFTPAASDVALTDLLVHYLWAYGPATPAHVAQWLSIPRPFATDMFEMAADRLEPVDLEGERAWVIADDRVFDQEPPSGLRLLPYFDAYVIGCHPRDRLFAGRAAQRALANGQAGTFPVLLVDGRVAGVWHQRKSGRRIDVTVEPLDELSAAQRRALDEEADRLAAFFGAKVSVRIGPVTVGGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Z4</accession>
    <name>F4F5Z4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734206.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22265"/>
    <dbReference type="EnsemblBacteria" id="AEB45553">
        <property type="protein sequence ID" value="AEB45553"/>
        <property type="gene ID" value="VAB18032_22265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22265"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_11"/>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="382" mass="41726" checksum="DBF07800A90489A0" modified="2011-06-28" version="1">MTLLRSSLRPYGTSIFTAMSQQAARQQAVNLAQGAPDFGPPAALLAAADEAVRRGGHQYSMSIGVPALRQAVAADLLRRYRRQVDPETEVTVTAGASEAIWCAALGLLEPGDEAIVLEPCYEQYPPTVTAAGATVRYVPCDFPEFRLDPERLVEAFNPRTRLVFLNTPWNPAGRVLREPELTLIGELAEKYDAYLVADETYEHLTFDGVAHLPVAEVAACRDRTVTISSVSKTFSATGWRVGWAVAPPALTAALRAVKQFVTFAPATPLQLATAVMVNEAPASGYYELLRAQYAQRRAVLRDYLQRTPLTLADNEGTFFLLGRCADDDVEYCTELIHSRGVAAIPASRFYADPQRGRGLVRFAFCKRLDTLRLAGDRLTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Z7</accession>
    <name>F4F5Z7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22280"/>
    <dbReference type="EnsemblBacteria" id="AEB45556">
        <property type="protein sequence ID" value="AEB45556"/>
        <property type="gene ID" value="VAB18032_22280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22280"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2025761_0_0_11"/>
    <dbReference type="OMA" id="RDECYAV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="122" mass="13350" checksum="117752F1B6FD6C37" modified="2011-06-28" version="1">MRVDTENRTGDTGDDQVLRRLRDECYAVVLPGVPVTADDDLFEVGGDSVMLIRLVAMAQLAFGVEIDALRYFQRPTLATLAAEVRQGLAPQAVDDRLLDDVLARVESMTDDEVQRLLDGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F636</accession>
    <name>F4F636_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735437.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28586"/>
    <dbReference type="EnsemblBacteria" id="AEB46788">
        <property type="protein sequence ID" value="AEB46788"/>
        <property type="gene ID" value="VAB18032_28586"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28586"/>
    <dbReference type="eggNOG" id="ENOG502ZFP0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228762_0_0_11"/>
    <dbReference type="OMA" id="GWQVNTQ"/>
    <dbReference type="OrthoDB" id="1663019at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="24527" checksum="FFB9593BAFD2E368" modified="2011-06-28" version="1">MSDAHRTARQLDEGAPPLDLTDEPIELSNRDPQDDPDRPTARGRRRRVVIALLAVLALTGVGALGAWGWRIVQQKDTLIATPDTIAGLTRDDSERAVSTADYLRSGLAADIQLDTSFGAVYQDPADERRSVLFFGGTTLLWQPERDLESLFGLMSDETGAVTGLRDMTPGRLGGVMKCGTTSGEGGDFAVCGWADHGSVAIAMFPFRPVDEAAGLLRKIRETVQTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F644</accession>
    <name>F4F644_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735445.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28626"/>
    <dbReference type="EnsemblBacteria" id="AEB46796">
        <property type="protein sequence ID" value="AEB46796"/>
        <property type="gene ID" value="VAB18032_28626"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28626"/>
    <dbReference type="eggNOG" id="ENOG5031S8D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1393730_0_0_11"/>
    <dbReference type="OMA" id="RHERVHP"/>
    <dbReference type="OrthoDB" id="2027811at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="205" mass="22267" checksum="9DB796C6F5103D16" modified="2011-06-28" version="1">MATISAVILAAVSVVGWQWWHNHPPYGPEALAVTSSLRFVSYDEAEAALGEAAHAPVTYGRDQLVLGRVSWQTPPKPLDGGYFAVFLIDKRTNHKPEVFGVAAPQSAVGIGSAGIENRIAERYSWLRGAGDATFGDDEYRSNGNRLHVADEKAAPLTFVALFPYVEEPDPELPRATAPVAMSDLLLALVYMGEDGQVYWAQRLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F652</accession>
    <name>F4F652_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28666"/>
    <dbReference type="EnsemblBacteria" id="AEB46804">
        <property type="protein sequence ID" value="AEB46804"/>
        <property type="gene ID" value="VAB18032_28666"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28666"/>
    <dbReference type="eggNOG" id="ENOG502ZWJ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048729_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="120" mass="12933" checksum="862EF6E463589751" modified="2011-06-28" version="1">MSNGAQVTGDGFPGGASVPVTVLRLDRPELDGTRLVVRAVDVELRERRRGHHLAPLGYLYDRADHDELESDLILDAGHYDAGDQTWSFSAEVPGIIGLTEPLSSADNPPAERVGKEGDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6B1</accession>
    <name>F4F6B1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731728.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09695"/>
    <dbReference type="EnsemblBacteria" id="AEB43057">
        <property type="protein sequence ID" value="AEB43057"/>
        <property type="gene ID" value="VAB18032_09695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09695"/>
    <dbReference type="eggNOG" id="COG1300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069787_0_0_11"/>
    <dbReference type="OMA" id="QVWTNNA"/>
    <dbReference type="OrthoDB" id="1745181at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="317" mass="34054" checksum="EB678F74398DCA15" modified="2011-06-28" version="1">MDLDAYVAEHGGEWRRLSQLCDRRRLDAAEVDELVALYQRVTTHLSVLRSRSPDPALLGELSQVVLRARARLTGRPRPSWAAVRGFMFAGFPGAVWRAAPWWCAVATVFTLLTFTLIGFVADNPETAAAFIGDEEAAHLVESGFAGYYTEFSAPTFAFHLWTHNAWLAAKCLAAGVLIVPVGYLLWQNVLNIGVVGGVMISYGRADVFFGLITPHGLLELTGVFVAAGVGLRTGWAWISPPEQLTRGQAVARAGRDAILVALGLVGVFAVAAVIEAFVTPAPVPTAVRIAVGAAAWLAFLAYVVLLGSRARADVDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6C1</accession>
    <name>F4F6C1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="4" type="ordered locus">VAB18032_09745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731738.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09745"/>
    <dbReference type="EnsemblBacteria" id="AEB43067">
        <property type="protein sequence ID" value="AEB43067"/>
        <property type="gene ID" value="VAB18032_09745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09745"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_0_0_11"/>
    <dbReference type="OMA" id="HGGYGVI"/>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="23563" checksum="6D17BF28477FEAEB" modified="2011-06-28" version="1">MDIVVKGRNVEVPDHYRVHVAEKLAKIERYDHKLIRAEVELFHERNPRQADHCQRVEITCFSRGPVIRAEACTSDFYSALDAAIAKLDARLRRAADRRRVHRGRHAPLSVAAATAGLPVTDLPSAALGAPASAATAVAERAEEDEYDDQPWHIAREKVHPAEPMTVDDALFQMELVGHDFYLFQDKESGRPSVVYRRHAYDYGIISLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6N1</accession>
    <name>F4F6N1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16265"/>
    <dbReference type="EnsemblBacteria" id="AEB44359">
        <property type="protein sequence ID" value="AEB44359"/>
        <property type="gene ID" value="VAB18032_16265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16265"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_1_1_11"/>
    <dbReference type="OMA" id="DPHIYCL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="540" mass="60023" checksum="FA8B33E931D24DBE" modified="2011-06-28" version="1">MLVGLVGCTSADNPEDDSGTLTPSDPTTFTVWITSAQQAPAPENKITKLLKDKLGVTLKYEIVTPDNEDQKIGVMLAGGEFPDLIGTGDLKQRLLQGGALRRLDDMLAKGDYPNLAEHVKDDIKKMSYSGDEVDKGLYILPNYNRFYGDVTGGVYYGPAFWIQKRVLADAGYPDLSNMTLDRYFQLISNYKAKHPQTAGAPTVGFEILASTGREWGMTNPPAQLAGFPNNGGVVVDSNNNASIFADKDIAKNFYKVLNQQYNSGVVDPESFTLTFDQYTAKLATGTVLGMHDQGWNFQTATQSLQSAGKDEYTYVPLMPVYDGVKPWYADRPVMNTNQGFGVSVSSKQPKKALKFLDIMLSEEWQKTLSWGIAGEDYQVGADGVFSRTDEQRKNYKDLTWRASNRLDALLDMLPKRNGQFSDGNAYSPDDQPAEFYATLSDYDKDFMAKYGKKTWLDFVNKAPDNPKYYPAWNLTLSDDANQVNQQLTDTSVQKLPGIIAGPPADFDKNWQAYVDSIRKIDVKVYEDAVTAGIKDRLANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6P1</accession>
    <name>F4F6P1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine exporter protein (Lyse/ygga)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_16315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16315"/>
    <dbReference type="EnsemblBacteria" id="AEB44369">
        <property type="protein sequence ID" value="AEB44369"/>
        <property type="gene ID" value="VAB18032_16315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16315"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079569_3_2_11"/>
    <dbReference type="OMA" id="FARMGHW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="198" mass="20703" checksum="FBF971A54F77326A" modified="2011-06-28" version="1">MGYLAVIAVLMITPGPDMMFVLTNATRYGARSGVIAALGVAAGETIHVAAVVCGLAAVITASPVLFTAIRWAGAVYLVILGIRAVRLSGTANHSHPERGATPRQAFLRGLVTNLLNPKMIMFSVAFLPQFVDPAAGDPTAQLILLGALFVAVQLTVDVTLGAGVGRLAHRMTDGLWSRRINRLCAFAFVALGVRLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6P4</accession>
    <name>F4F6P4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_16330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733032.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16330"/>
    <dbReference type="EnsemblBacteria" id="AEB44372">
        <property type="protein sequence ID" value="AEB44372"/>
        <property type="gene ID" value="VAB18032_16330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16330"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_2_1_11"/>
    <dbReference type="OMA" id="GFADVWH"/>
    <dbReference type="OrthoDB" id="1742732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="10"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="31550" checksum="704B36DA8F5EA249" modified="2011-06-28" version="1">MTTVHTPLDLEPLGPHFGALVHGLDLAIASDEEVTALRAALVDRKVLFLRDQRLDDDGQVRLGRRIGELTASHPVVGGVDDAHPEIYALDSTDNGFADVWHTDVTFMKRPPLGSILRAVILPPTGGDTTWADAQLAYDSLSEPVRRLVDQLTAIHDGTREFGYYLAQRGGNVWEGQQVSRLDPVEHPVVRVHPETGRRGIFVNPGFTSHIVGVSDFESRAILDLLYAHLTKPEHIVRHRWRPGDVALWDNRSTAHYANRDYGSARRVMHRITLRGDIPRGPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F773</accession>
    <name>F4F773_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10065"/>
    <dbReference type="EnsemblBacteria" id="AEB43131">
        <property type="protein sequence ID" value="AEB43131"/>
        <property type="gene ID" value="VAB18032_10065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10065"/>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3067413_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="53" mass="5631" checksum="30AC2151842AFBD1" modified="2011-06-28" version="1">MPPGVEAERVITAVLADLRSGEHRGVVVDSPPGTGNRQHLIGIRESSVLSTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7D0</accession>
    <name>F4F7D0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent transcriptional regulator, malt-like, luxr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10350"/>
    <dbReference type="EnsemblBacteria" id="AEB43188">
        <property type="protein sequence ID" value="AEB43188"/>
        <property type="gene ID" value="VAB18032_10350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10350"/>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015308_1_0_11"/>
    <dbReference type="OMA" id="VEGHVYR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="809"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="882" mass="93878" checksum="C8DA59ED69C03247" modified="2011-06-28" version="1">MELDRLHAAVTGPQGRGMFFTGSAGIGKSRLLREGMAALPAENYAVWWIAASATTAAMPFGGLVQVLPVEQPQGLSPAGILRWAVDVLQQQAAGRRIVLAVDDAHLLDPPSAALVHLVARSENACVVGTLRDGEQIPLPIRALWTDGLVEHAELSPLAPTETAGLLAAILGGPVDGGSSDRLGRLSSGNPLLLRELVHAAQGSEELTRRYGIWTWTGRLELAPSLTDLIDIRIGQLSPGVRTVVELVAFGEPLGLQLLYRAASQTDVETAEERGLITMVKSDRRLDVRLAHPLYGEVVRRQCPVSRTRRLQADLAELLEGVGKRRREDLLRVAVWRLDSGTAQDPSMLVAAAGQAFARYDVPLATRLARAALDADGGFNAAELLATILMFADRPAEALGVLDAVAPDSDDEDRLSRWLTARGMVSYWGLSQESTVEEIAERGASLTDLAAQARIRAFEGIMRLHRLDAPAALRLAQGVLDRPAASTAARELARCTIAHLQAVQGQLCRSATAVDLVQAKAASWRADMPYLQLAVELARGTRLALSGDLAGIDRLVADEFADLADAGDFRLGSGYLAILRAYAARLRGRSDTALQAALGACAILATSRVYAGLAQAERAQAAALRGDARQAAEAMAEADRIHAPNMAVLYPWLEQARAAALAVGGDLPAAVAHLHDLVGRLRADGFTGHEVLALHDLVRLGEAGAATGPTCSDDNRRTVAQRLAELSERVDGDLPPLLARHARAAVEGSPEQLLSVADNFMDLGLALPAAEAAAGAVHLLRQRRSPDIAVASERLAVLLGCCDLVQTPALRAATPVLTEREWQVARLAADGETSRAIAEQLFLSARTVENHLQRVYTKLGLNGRAELKAALRTIPGHDGTTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7D3</accession>
    <name>F4F7D3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731862.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10365"/>
    <dbReference type="EnsemblBacteria" id="AEB43191">
        <property type="protein sequence ID" value="AEB43191"/>
        <property type="gene ID" value="VAB18032_10365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10365"/>
    <dbReference type="eggNOG" id="ENOG5032Z6K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087287_3_0_11"/>
    <dbReference type="OMA" id="KPMVMAY"/>
    <dbReference type="OrthoDB" id="1738659at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="1">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="166" mass="17981" checksum="7080B4853D25936B" modified="2011-06-28" version="1">MSMFRRQGDRYVASLAVDEVRVLRKVASEVVGLLTDGFDHTDPVVCRLFPEVYPDDAAGTAEFRRYTEGDLKTAKIDQAGAILAALPGEGGGEVLLDAEAAEAWLRALNDARLAMGVRLEIKDGTDLGAELDDAVAEDPSSSRVFQLSVYAYLGYLQESLLNALIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7J5</accession>
    <name>F4F7J5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component transcriptional regulator, winged helix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733094.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16650"/>
    <dbReference type="EnsemblBacteria" id="AEB44434">
        <property type="protein sequence ID" value="AEB44434"/>
        <property type="gene ID" value="VAB18032_16650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16650"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_101_2_11"/>
    <dbReference type="OMA" id="THVWGHR"/>
    <dbReference type="OrthoDB" id="1287053at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="172" mass="18841" checksum="EE693A532A8B1A6D" modified="2011-06-28" version="1">MRVVDVNRDVPVGEAEARRVGEVLTVTVHLRIGPGAHEHVDLFAALLALLGGDWPPASPSARDSGAHLRVHPQARAVYRGGAEIVLTRREYDLLWCLVANPRQVFTRAQLLDRVWGHPYASPRSVDVHVRRLRAKVGADLPVVTTLRGVGYRLGVDCSVEVVDDPASNWPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F872</accession>
    <name>F4F872_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transporter inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_10575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731904.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10575"/>
    <dbReference type="EnsemblBacteria" id="AEB43233">
        <property type="protein sequence ID" value="AEB43233"/>
        <property type="gene ID" value="VAB18032_10575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10575"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_11"/>
    <dbReference type="OMA" id="QGAFIML"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="317" mass="34534" checksum="0E37759F14BA7AC9" modified="2011-06-28" version="1">MVRFVLSRALKAVLTVWIAITSTFFLLRLLPGDPTTLMVEGDMTPEMQAALLKTYGLDRPLWEQYVSYLRELVQGNLGISFRQIQPVTDIILDRLPWTLLLAGSAFVLTVAVGIPIGVTAAVNRGKWLDRALQGFGISANALFVPSVAILLLVFFGAQLGWFPIGGAIDPDTRGLGAYLSLAHHLVLPVLSLVLVQLGPYALTLRTNMIEVLGEDYIRAAQARGLSARRRVWKHGLRNAILPALTLMGLQLGTLVGGAVLTETVFAYPGVGRLIYEAVGQQDYPVIQGAFIMLAVTVVFANALTDMLYAVLNPRIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8B2</accession>
    <name>F4F8B2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731944.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10775"/>
    <dbReference type="EnsemblBacteria" id="AEB43273">
        <property type="protein sequence ID" value="AEB43273"/>
        <property type="gene ID" value="VAB18032_10775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10775"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784561_0_0_11"/>
    <dbReference type="OMA" id="WGATDHA"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="33773" checksum="CD50A8F3EB788C04" modified="2011-06-28" version="1">MQSRDFGRLGSVSALTLGGGGIGNVWGATDHAEAVATVQAAIDGGVTMLDLAPTYGDGYAAENVAGAALRAMPAADVLVTSKIELPEQDGGDLPEKMIRSLHATLDRIGREHLDLFLLHSQLHPHGWTGPTPRTLGWDLYLDQVVPTFERLRAEGKIRAWGLTGVGHPQTVIEAMHRQPRPDAVQAVVNALDLSGDMWLLGSSAEPRNDEIRQAAVDDGVSVIAIRAVAAGALTEGIDRAVDDDSPVAVDFARAEPFRALAAEFGESPASLAHRYALSVPGVATVVLGVKNRAELAECLAAEARGPLTEAELKALRDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8C4</accession>
    <name>F4F8C4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44469">
        <property type="protein sequence ID" value="AEB44469"/>
        <property type="gene ID" value="VAB18032_16825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16825"/>
    <dbReference type="eggNOG" id="COG2405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127151_0_0_11"/>
    <dbReference type="OMA" id="VHELVAI"/>
    <dbReference type="OrthoDB" id="1821593at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="19852" checksum="715A93EACD94614B" modified="2011-06-28" version="1">MSRPPHVTSVLVLDTMILSHFTLADRLDVLQDLLLDAECWTTQVVREELRAGSEDHRELAVACEADWLTTAQLDTLDEVRCFTKWAARLGSGERDLGEASVLAAAELREGVAITDDRNATQVARAYGARVHGTIWLLAAACRDGKQTLTAAGNLIEALRATGARLPCSGAEFPDFARKHNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8P2</accession>
    <name>F4F8P2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734437.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23435"/>
    <dbReference type="EnsemblBacteria" id="AEB45785">
        <property type="protein sequence ID" value="AEB45785"/>
        <property type="gene ID" value="VAB18032_23435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23435"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014270_2_0_11"/>
    <dbReference type="OMA" id="GETCLLY"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="327"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="576" mass="61020" checksum="3179C009CD5C00A0" modified="2011-06-28" version="1">MTGADVRDIDPGDGRFTPSAPQAPAWSPAASTAAPPTIDSSEFAGWPEIVEHLREGLVLCGPDGVVWQVSPVAQRLLPEIVVGGSCAVFDALDGSTAEIVRNGRRLRVRRVPLSAGPTCWYVEDVSEDSGPADELAAERARSAFLAVVGEKLGNPLHPDRAAAAVVRLAVPTLAEAAVLILAPRSGRARWWRARRAEDDLPTLDRGVLAAAELPAAVIDSLHGVQPHTVDWLAEQAVEAGWLPGIDAADASVRLVALPGRDAPVGVLLVARPAAHWYTDDDLDLLRAFADRAGAALTTALLYRNQAEVADTLQASLLPVEPAEVPGVQWGTAYRPAQAGLRIGGDFYGSHRLPDGGSVFFLGDVSGKGVEAAVFTGQLRQCLHALHRIEAQPARLLRLLNDALLESTLAHGQGRFATMVLGVVRPHRDGGLVLTLAGGGHLPPLVVRSTGEVEQLPLNGMLIGVVPDPRVSQVSTRLAPGETCLLYSDGVTEARGGRRGAEQLGTERLMQALTGCQRMPAPALAERVEQITCDWLAQRDHDDIAVLALRATGTRPHRHLHAVPTPTPVVREGATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8T9</accession>
    <name>F4F8T9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735667.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29741"/>
    <dbReference type="EnsemblBacteria" id="AEB47019">
        <property type="protein sequence ID" value="AEB47019"/>
        <property type="gene ID" value="VAB18032_29741"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29741"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OMA" id="PYAVLAW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="460" mass="48018" checksum="FC7E6E61974A36BB" modified="2011-06-28" version="1">MQPTRIGSYRIERLLGVGSFATVWLGYDESLDARVAIKVLAENWSHDLRVRERFRQEARLLWRLDHERLVSVHAVGELDDGRPYAVLAWADGGSLRDRLADGPLPAAQSVRLLREVAAGVAVLHDSDVVHRDITPGNVLFRTRATGEEQVLIADLGLAKALAAASGLTARAGTPGYMAPEQDDPLAIVDARADVYGLGRLGVTLLAVPREGQPTATTFRLRPEVPAAVAAVLRTATAAVPADRYPDAAAFGTALDKALAAPSKVAEPDVPTPPRRRLAMVSALAAVACLTLAGTVGGAAWAWSQRGPQTGTDTSGRVSVTLPDGWRVAGSGWSGQRNAAGGLEPAMLISPDPDRWASDPGVPGAFVGASAALAAETTPRRLVTDREHAQCVASGVRTTRQAGIDWTVASFTGCSSGKPEVIEAAGLTPDGGRLVYVQVAPPAGGGTSFVDSLLAGVRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F981</accession>
    <name>F4F981_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04915"/>
    <dbReference type="EnsemblBacteria" id="AEB42109">
        <property type="protein sequence ID" value="AEB42109"/>
        <property type="gene ID" value="VAB18032_04915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04915"/>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095704_0_0_11"/>
    <dbReference type="OMA" id="KRLVQRW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="26896" checksum="A945D30F3878020E" modified="2011-06-28" version="1">MTVPNTALRAVRTGMRMSQDDFARALQAAGHRVGEPNDANKRLVQRWESGAITAPRPVYARALEVVTGLPISLLGFAAVPNGNVADDQHGGHDLTTPMSDLATPTPSARTATVHRSYEGVWLSRYQYYSSGRGDSFAGQHFLVMLQHGDRLTARSLPGSASSSLSLDLTVDGAVVTGTWVEQTDPAGYYRGARYHGAIQLLAEPTGRRMAGKWVGFGKDMDVNTGPWELIFRDASTSKATLDLYNTSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9G3</accession>
    <name>F4F9G3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_11195</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732028.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11195"/>
    <dbReference type="EnsemblBacteria" id="AEB43357">
        <property type="protein sequence ID" value="AEB43357"/>
        <property type="gene ID" value="VAB18032_11195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11195"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_11"/>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="12">
        <location>
            <begin position="45"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="10">
        <location>
            <begin position="232"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="11">
        <location>
            <begin position="431"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB43357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="620" mass="65943" checksum="9DE5B3675E990857" modified="2011-06-28" version="1">MTRPTPETLAHSVRRARGSAETTGDNDHTRAAATAPAVRPAQVSGAGSLVRSLEALGVDVVFGIPGGAILPAYDPLYDSTVRHILVRHEQGAGHAATGYAQATGRVGVCIATSGPGATNLVTPIADAYMDSVPLVAITGQVARPAIGTDAFQEADIQGITLPITKHNFLVQNASEIPRILAEAFHLASTGRPGPVLVDIPKDVLQAETTFAWPPTLDLPGYRPTMHPHGKQIREAARLMTTARRPVLYVGGGVLKAGATEGLRRLAELTGIPVVTTLMALGAFPDSHRQHLGMPGMHGTVAAVYGLQKADLIVALGARFDDRVTGKLDSFAPDATVVHADIDPAEIGKNRHADVPIVGDARYVIDELLAAVTAERAAGRVAELGDWWTQLDDLRARYPLGYEEPSDGTLSPQYVIKRLGEIAGPDAIYVAGVGQHQMWASQFISYEKPQTWLNSGGLGTMGYAVPAAMGAKVGRPDTVVWGIDGDGCFQMTNQELATCALEGIPVKIAVINNGNLGMVRQWQTLFYGERYSNTDLGTHKHRIPDFVKLAEALGCVGLRCETAEDVDKTIEAAMSINDAPVVIDFVVGKDAMVWPMVAAGTSNDEIMFARGVRPTFDEDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9J7</accession>
    <name>F4F9J7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733230.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17365"/>
    <dbReference type="EnsemblBacteria" id="AEB44575">
        <property type="protein sequence ID" value="AEB44575"/>
        <property type="gene ID" value="VAB18032_17365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17365"/>
    <dbReference type="HOGENOM" id="CLU_921166_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="33944" checksum="5CD983442D5D0A90" modified="2011-06-28" version="1">MRDLKRFTADWAISVLGTLVSLVAIVATLLAGISGPMSVALGLTGVATSLLFGMMQKLNEIKEEQARAHRELDQGWTRTESALRSVTETYDFISRGANLGLFDPEVKRLAKIGQASRAEKLDHILVEQAVARVRNTLDDLSGLADGRLQLDFTYSNVLLDLMRSATTEVLGSSPAEVEDVWWQLPLYREYLEIQRSLIADRGVRISRIFISENVTPKLYDLMEIEANIGINVKWVQNRRIQKSLRESFVVIDGRIMHRTVSMSDHDDDNHFSQNAADIASYAGKFHRLLPFSQDLASVRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9M7</accession>
    <name>F4F9M7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733260.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17515"/>
    <dbReference type="EnsemblBacteria" id="AEB44605">
        <property type="protein sequence ID" value="AEB44605"/>
        <property type="gene ID" value="VAB18032_17515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17515"/>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010992_0_0_11"/>
    <dbReference type="OMA" id="REWNDIR"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307748" evidence="3">
        <location>
            <begin position="20"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="786"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Big_3_5" evidence="4">
        <location>
            <begin position="877"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="966" mass="103026" checksum="7371DFEAB7305813" modified="2011-06-28" version="1">MLALGALLSTSFAATPSYAADDQLNEGLVHRFALDETSGTTLVNSGSAGAAANATLVNPQKATLTGNGVRFNPDSYEGALEGAYVKLPDNLTAGMSNLTVDYDVWIDPANVGEHQMWSFGAKSGSCDADTGGQGAIFASNTQRFRVAVGSANLQQNRVRMTEGAWTHVTYTQSLNPNGTSWTGRLYLDGVLHATQTNLTTPPSVNAAGTNCNFLARSQNSGHYSFRGTLRDFRIYDRAVSPDETLALAQRTVSDGVRADAAAIDLGLTSAIVRDIVLPKVGSAAGSAITWTSSDPSVVAVYTPPALTSARKVPVTGRITRPAQGQPDATAVLTATVRKGATEVATRDIPVVVKAEFDNAQAVDRDTLDLTLYATDDVRGNINLPATGEFGSTITWTSTTDLVTGTGEVTRPAFGRADVEATLTATITKGSASKTKSFPVTITAMPRTEEYERYFMGYFKGEGIADGEQIMFATSNGNTALDWTGLTGGRPSLISQLGDQGLRDPHIVRSPDGDTFYMIATDLNWYDQGGYAINDTQYIEVFESHDLVNWTPQRHVKVAPDDAGNAFAPESLWVDEIGAYVVFWAQSLWNNPVNRTGQGNAQMWYATTRDFQTFSAPQVWQDPAPLSRIDTTAIKVGDHYYRVTKNEAGNQGSDIFSEKHTDFLDSNINNWTLLAPALGRTTWVANQGYEGPVIFKANPGDTACPGEFYLWGDRYTNGGGYQAACHEDIEAPTWNAKPITMTNAGVVRPRHGTVIPLTLREWNDIRGIPNSDVTTTTEVSVEPYASGAQTTTATATVTAADGFETGGQVRFSVGSWSEVAYLTDGAATVTLPTGLPAGTRSVKAEYLGVDYLKASAGTASVQVPQGSKAVKVHAKAAPASVVRGDTFTLNVTVEPKGGPKKDASTPTGEVTVTFADSVQVVSLVDGKAVVTLQTAGLKRGNYRVHVAYSGNPTYQGHADTYQNLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9N6</accession>
    <name>F4F9N6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Permease component of abc-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17560"/>
    <dbReference type="EnsemblBacteria" id="AEB44614">
        <property type="protein sequence ID" value="AEB44614"/>
        <property type="gene ID" value="VAB18032_17560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17560"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451198_0_0_11"/>
    <dbReference type="OMA" id="HAQAPLW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="544" mass="57939" checksum="53BCD4C32E11924F" modified="2011-06-28" version="1">MSLAAPTMTAGRTGPDRGTRIGIGFVLLLPALLALAWSYLLPTVQAVWRSTQRDQLLGPAEGVGSANYEQLFTRGFLGDLGSALLLALVPLLLALLVAPVLALLADRAGRPARLALRALVVLPVAGYAPVALLIGWRLDRMEPGTMLDRPLATLVEFTAVTGAGLVVAVATTAFLSTLRGRPHRRDALPAALTVAGLLMLGIIALTLQTFTPTLITGNSRTPMTYVVLQSLQQMNLGGGSAAAVMLLLPLALLGLAATALLLLTRVRIEVVDEAVTHREQPHGAVSKSAPVTESTGDRQARIGLAVAGAVVVAVMLWAAWPWLRRSLRFTNETVPMPSPDLSGMLTATWLPTLLSAVVTVAVAAAAGFAIGGLRPLGRFSELLLLPFAPWLFVGTGPLAIESYLRARDFDQLNTFLGLVPPGWVSIPALFLFTVLFRGLEPRWRAGAGFGRAMLAPAAPMILLVGLVTWLVTAAQVLWPFVVASTPMYRPAPLEALMVYARWGMRGDELALGAVLPLPMMLIFLVAFGWLQVKYLDRLAVRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9S3</accession>
    <name>F4F9S3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_23755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734501.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23755"/>
    <dbReference type="EnsemblBacteria" id="AEB45849">
        <property type="protein sequence ID" value="AEB45849"/>
        <property type="gene ID" value="VAB18032_23755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23755"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_11"/>
    <dbReference type="OMA" id="YRYIKYK"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="424" mass="44481" checksum="ED30EB5BFDCE693B" modified="2011-06-28" version="1">MTGRRTVVTGIGVVAPGGVTRDRFWKTITEGRTATRRISFFDPTPFRSQTAAECDFDPDAAGIPLERRRRADRYVQFALACAAEAIADSGLDLTDAERDGAGVVLGTAVGGTMALEQEYVTVSDSGRRWLVDAGLGGPYLYQALVPSSLAADVACAHGLHGPAQVISTGCTSGIDAIGYAHQLIADGEADIVLAGAADSPISPVTVASFDAIGATSPDNDDPAHASRPFDADRHGFVLAEGAAVLVLEEAGHARRRGAHIYCEVAGYASRSNGYHMTGLRPDGVEMGLAITDALRQARLAPQDISYISAHGSGTRQNDRHETAAFKRALGPAAYRVPISSIKSMVGHSLGAIGSIEMAACALAIEYGVVPPTANWTTRDPECDLDYVPNEAREVPVDVALSVGSGFGGFQSAMLFRRLAREVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA07</accession>
    <name>F4FA07_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_00170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00170"/>
    <dbReference type="EnsemblBacteria" id="AEB47118">
        <property type="protein sequence ID" value="AEB47118"/>
        <property type="gene ID" value="VAB18032_00170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00170"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_15_5_11"/>
    <dbReference type="OMA" id="WVIYVVA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="437" mass="45669" checksum="875F283BA11B8E6E" modified="2011-06-28" version="1">MRTVLRRPDFRLLFGGLLASMIAESMLLLALAIWVKDLTGSDALAGAIIFVIIAPRVLAPLVGWVVDRYPRRRVFVVTNLAMALLLTPLLAVRDAGDMWIIYGVAALYGLANLTVGVVLSRLIRELVPTDLLGEANGVLQTVRQGLRLVGPLAGAGLYALVGGGMLATVGIAGFLVAAVVVGGLPFAEPAEDPAEDCPVTRRWRVQLVAGLRHLVDEPAIRRALVGYGLGSLVMGFTESLIFAYVDQGLGRDAAFVGVLVTVQGVGGLVGGLVSAAVLRRVGEVGTLAAGVAFFGPAALALAYPNMWLGFAAVLMAGVSLPLTMVGLHTLVQRRTPPEVLGRAAAAAEAVTRVPQALSIGAGALVVGVLDYRLVFVAVGLVTLLAAAYLWRGRQLSPPAGQPARPRIPAPRPAPEGRARPAPEDRKDGNTAVSTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA34</accession>
    <name>F4FA34_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
            <shortName evidence="3">GlcNAc-Ins deacetylase</shortName>
            <ecNumber evidence="3">3.5.1.103</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mshB</name>
        <name evidence="4" type="ordered locus">VAB18032_00305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate</text>
            <dbReference type="Rhea" id="RHEA:26180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:52442"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="EC" id="3.5.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MshB deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.103" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00305"/>
    <dbReference type="EnsemblBacteria" id="AEB47145">
        <property type="protein sequence ID" value="AEB47145"/>
        <property type="gene ID" value="VAB18032_00305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00305"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_2_1_11"/>
    <dbReference type="OMA" id="YWNRVPR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035595">
        <property type="term" value="F:N-acetylglucosaminylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01696">
        <property type="entry name" value="MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017810">
        <property type="entry name" value="Mycothiol_biosynthesis_MshB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03445">
        <property type="entry name" value="mycothiol_MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="32708" checksum="8DA2216F1BBD942B" modified="2011-06-28" version="1">MTVVTTLPDRRLLLVHAHPDDESIGTGSTMAHYAAEGAHVTLITCTLGEEGEIHVPALAGLAAAEADQLGGYRIAELAAACAALGVTDHRFLGGAGRYRDSGMMGLSTNQHPRAFWQADLDEAAGQLLEVIREIRPQVVITYDENGFYGHPDHIQANRVTMRAIELAAQEGLAPAKVYWTAMPQSVLEAGMTHFEESSDNPFAGITDATELPFCTPDEQIAARIDATEQHAAKEAAMRAHATQIPATSWLYTIAGNFGAEFMGVEYFTLAVGTKGPGSGPYGWESDLFAGLDVGGVSQPTAVVSAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA63</accession>
    <name>F4FA63_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Channel protein, hemolysin iii family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_04990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730798.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04990"/>
    <dbReference type="EnsemblBacteria" id="AEB42124">
        <property type="protein sequence ID" value="AEB42124"/>
        <property type="gene ID" value="VAB18032_04990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04990"/>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051078_2_2_11"/>
    <dbReference type="OMA" id="YHRRVWS"/>
    <dbReference type="OrthoDB" id="1659567at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="225" mass="24715" checksum="D165AD948085E91C" modified="2011-06-28" version="1">MTTSAPSRLKPVDIGKPRMRGWLHTYAFFVAVVCGIVLCSIAAARPGWTPLISCAVYSFTVCGLFGTSALYHRRVWSTRGFQVMRRMDHSMIFLFIAGTYTPFCLLLLDNRATVTMLAVVWGGALAGVALKMVWPHVSRWVSAPLYLALGWVAVAILPDILRQGGVTALVLLSVGGAIYTVGAVFYALRRPNPWPTVFGHHEFFHACTLVAAICHHIAIYFALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAL1</accession>
    <name>F4FAL1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase, sigma-24 subunit, ECF subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733281.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17620"/>
    <dbReference type="EnsemblBacteria" id="AEB44626">
        <property type="protein sequence ID" value="AEB44626"/>
        <property type="gene ID" value="VAB18032_17620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17620"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_666710_0_0_11"/>
    <dbReference type="OrthoDB" id="1124440at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Unchr_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309196" evidence="1">
        <location>
            <begin position="36"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="413" mass="43930" checksum="0C89333B5760DDA4" modified="2011-06-28" version="1">MTSRTVSRRRLVWALATLTCLAGAAGLVAVPSAKADRSAPIVGVAGKCVDVQWSGTQNGTIVQLWDCNGTNAQNWAGIGRQGTLRAFGKCLDVDGGSHDDGARVQLWDCNGTGAQDWLLENGQLINTGSGKCLDAFGGAQTGTALQIRGCSGVVTQTWAASGSPQVAGPEAKKGVATWAFPPGGDGIRDVGATWYYDWSTSGSDVPAAAEFVPMIWGATFVTDADLATAQRSGRTLLGFNEPDLPGQANMSVEHALDLWPRLQHTGMRLGSPAVAFGADTPGGWLDRFLAGVRERGLRVDFIALHWYGSDFGDEAANHLMQYVHAVHERYRLPIWITEFGLIDFSQGAPRHPTPQQLVTFIDKATAALQATPYVERYAWFALPASGEHAAHGLYREDGTATEAGAAYRAAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBH0</accession>
    <name>F4FBH0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative plasmid replication initiator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730939.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05700"/>
    <dbReference type="EnsemblBacteria" id="AEB42266">
        <property type="protein sequence ID" value="AEB42266"/>
        <property type="gene ID" value="VAB18032_05700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05700"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041009_0_0_11"/>
    <dbReference type="OMA" id="FGGHFLT"/>
    <dbReference type="OrthoDB" id="1001099at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="520" mass="56720" checksum="10FB1F8F02ECF18F" modified="2011-06-28" version="1">MSAPLTLSRPGLAAGRIAHALHRAVTPDYFGWLEHTASAGGCSRPIRLTGTLASVEADTGRVIRELHTDELPDRAIYKACGNRRASQCPDCAWVYAGDAFQVVRTGLTGGKTVPATVARHPVVFATFTAPSFGAVHHRHVSRHTCATRQRCDCRPSPCRARRDAGTCEHGQPAACFARHDADDPQLGRPLCLNCYDHDHQVVWNGFSGELWRRTKQAIERHLAALCRQRGISHVQVVTDSGRVRRMPPVRVSHGKVAEMQRRGAVHFHVLLRLDGVDPGDKDALVPPPAGITADDLDDAVHAAARQITVTTPPHADQPNGWPITWGEQVDVRRIGSGDGDVTDAKVAAYLAKYATKATEVTGHASTRLTPDTIDAYANPDGDHLARLIDACWRLGRPTATRTTGSNAQPGDRQGHLDTNPYAGLRRWAHMLGFGGHFLTKARRYSITFGLLRDTRATYRRTEDNETADTLTVGTLTYLGAGWRTDGDALLANTAARQRRESRRIGREELAHDAWLAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBJ9</accession>
    <name>F4FBJ9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732130.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11735"/>
    <dbReference type="EnsemblBacteria" id="AEB43461">
        <property type="protein sequence ID" value="AEB43461"/>
        <property type="gene ID" value="VAB18032_11735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11735"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_11"/>
    <dbReference type="OMA" id="ACMEREF"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="20283" checksum="4E204C92395B6E44" modified="2011-06-28" version="1">MTIATTERLLVRDWTDRPADLARLFEIYSRPEIAQWLGAASRFPLTDPAQAAELLARWHRRHAAYGERYGLWAVEVRETGVVVGTVMIKPLPGRDEQVLTDDIEVGWHLHPEAWGNGYATEAARACMEREFATGTPLIHAVIAPGNTASMAVARRLGMTPVGRRSDWYGGEELETFVLARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBM7</accession>
    <name>F4FBM7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11875"/>
    <dbReference type="EnsemblBacteria" id="AEB43489">
        <property type="protein sequence ID" value="AEB43489"/>
        <property type="gene ID" value="VAB18032_11875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11875"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_0_3_11"/>
    <dbReference type="OMA" id="NPGQHEI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="119"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="454" mass="49533" checksum="613CFC20889D1829" modified="2011-06-28" version="1">MRKGPLTLEQLRVAVAEGEIDTVALALVDMQGRLQGKRFHAPYFLDQVVGHGSEGCNYLLAVDVDMNTVDGYAMSSWERGYGDFVMKPDFDTLRRVPWQPGTAMLLADLEWPDGGGPVVASPRQILRGQLDRLAAHGLTAYAGTELEFVLFRDSYEQALARGYRDLTPANQYNVDYSLLGTARVEPLLRRIRNQMAGAGLTPESAKGECNLGQHEIAFRYDEAVACADHHVIYKNGAKEIAAQEGMSITFMAKPNAREGNSCHIHFSLRDASGGSAMLGDGPAHLSVTGQRVLAGLLATMRELSLLFAPNINSYKRYQPGSFAPTALRWGTDNRTCALRLVGHGQGMRVENRVPGADVNPYLAIAALVAGAVRGIEQELELPPECTGNAYDDAEADRVPGTLRDALTLWESSTMAREAFGAEVVAHYANMARVELSAFDAAVTDWELTRGFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBP3</accession>
    <name>F4FBP3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">infB</name>
        <name evidence="11" type="ordered locus">VAB18032_11955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732174.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11955"/>
    <dbReference type="EnsemblBacteria" id="AEB43505">
        <property type="protein sequence ID" value="AEB43505"/>
        <property type="gene ID" value="VAB18032_11955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11955"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_9_4_11"/>
    <dbReference type="OMA" id="QVRPEMI"/>
    <dbReference type="OrthoDB" id="347113at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="486"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="495"/>
            <end position="502"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="545"/>
            <end position="549"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="599"/>
            <end position="602"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB43505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="995" mass="101689" checksum="B541FEECF55EEE35" modified="2011-06-28" version="1">MAGKARVHELAKELGVESKTVLAKLKEMGEFVKSASSTVEAPVARRLRSAFVASGGAGAPAAAPSAAPAPAAPTPSPTPGEPRITAKPTPPRRPAAPGPKPKAPVPGPPPPAAPVAKPASAHDIEVAAAEARAAALKAEQEAAVKAAQAARQQQRDNVRREAPAEGTARPGPRPGPGNMPPRPGSPAAGRPGGPTPGPGGRQGRPPARGAGNNPFGIQGSQQQRPPAAGAGGPRPSPASMPPRPSPASMPPRPSPASMPSQRPGRPGGPGAGRPGGGGGAGRPGGGGGGGGYRGGPGGGGGGGGYRGGPGGGAGGGGYRGGPGGGAGAGGGFRPGAPAGGGGRPGGGGRGRGGGAAGAFGRPGGKPTRGRKSKKQRRQEFDNLSAPTMSSGAPRGQGQTVRLSRGASLSDFADKINANPGSLVQEMFNLGEMVTATQSCSDDTLLLLGEHLGFNVQIVSPEDEDRELLAQFNIDLDAEVAEDRLVSRAPVVTVMGHVDHGKTKLLDAIRKANVVAGEAGGITQHIGAYQVHVPHEGEDRAVTFIDTPGHEAFTAMRARGAQVTDIVILVVAADDGVMPQTIEALNHAKAADVPIVVAVNKVDKPEANPDKVRQQLTEYGLVAEEYGGDTMFVNVAAKPGIGIEDLLEAVLLTADASLELTAPIDGPAQGVAIEAHLDKGRGAVATVLVQKGTLRAGDSIVAGGAHGRVRAMLDENGNQVTEAGPARPVMVLGLTAVPGAGDTFLAAADDRTVRQIAEQRQARRRAAAFANSRGRATLETLMEQLKEGEKTSLNLILKGDVSGSVEALEDALFNLDIPEEVQLKVLDRGVGAITESNVMLASASSEPVTIIGFNVRASNKVREMADREGVEIRYYTVIYQAIEEIEAALKGLLKPEYEEVELGTAEIRDVFRSSKIGNISGCIVRSGVIRRNAKARLLRDGTVVADNLTISSLKRFKDDATEVREGFECGLTLGGYNNVQVGDVIETFEMREKVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBQ0</accession>
    <name>F4FBQ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732181.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11990"/>
    <dbReference type="EnsemblBacteria" id="AEB43512">
        <property type="protein sequence ID" value="AEB43512"/>
        <property type="gene ID" value="VAB18032_11990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11990"/>
    <dbReference type="eggNOG" id="ENOG50325PD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2261803_0_0_11"/>
    <dbReference type="OMA" id="PAWMLDP"/>
    <dbReference type="OrthoDB" id="2231669at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="106" mass="12176" checksum="E544FC8EDC59C081" modified="2011-06-28" version="1">MTRDGTPTEQPATDETIRLRTPRQASTLPAWMLDPPPPRRTLGVRVGQAFAALPGAGRLRRRWWAWQDRDRLYQRYPIAFKLVAMVVSWVVVMALVLLVYALYGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBU7</accession>
    <name>F4FBU7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733402.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18225"/>
    <dbReference type="EnsemblBacteria" id="AEB44747">
        <property type="protein sequence ID" value="AEB44747"/>
        <property type="gene ID" value="VAB18032_18225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18225"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="277" mass="29927" checksum="1516945B2D6942F3" modified="2011-06-28" version="1">MNRRYSAQIGRYLLVFALVVVAVAALYPLLFTVVSSLKTQTGFARDPLGLPSGITFDNYVEAFKRMNMPRLLLNSIITTVGGLVLSVLAAMLVAYTVTKLRFRGGKLVFLFIIVTLTIPSQAIIYPLYQTVLDLGMSGEYQGLILAYAAFGLPLGTYQLAGYFQQVPDELIEAARVDGAGHFTILFRLLAPIATPALAALAIFNFVWMWNDLLLPLVIMGGSDSKTLMVGVSLLSGQYDVSVPLVSAGLIVALLPVLIIYLVFQRQLISGALAGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC38</accession>
    <name>F4FC38_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734688.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24690"/>
    <dbReference type="EnsemblBacteria" id="AEB46036">
        <property type="protein sequence ID" value="AEB46036"/>
        <property type="gene ID" value="VAB18032_24690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24690"/>
    <dbReference type="eggNOG" id="COG3482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045640_0_0_11"/>
    <dbReference type="OrthoDB" id="1772930at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012924">
        <property type="entry name" value="TfuA_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07812">
        <property type="entry name" value="TfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfuA" evidence="1">
        <location>
            <begin position="49"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="456" mass="49836" checksum="6025721D859C7520" modified="2011-06-28" version="1">MTIHVFLGPTLPRERAQELLPEATFLPPVSQGDVLRSVARRPSAIGIIDGRFHDVPAVWHKEILWAISRGIPVYGSASMGALRAAELAAFGMRGVGEIFTAYHEGSLNDDDEVAVAHADADDGYRPVNEAMVNVRATLAAAANAGIVAERTATDLVQLAKQTYYLGRSYPQLLAAGEAAGLPADELAALRAWLPGNRVDRKARDAEAMLRLMAQERGADVPPANFTFEHTAFFEQARQTAGELGGVAGAAANTDDGDPASVTALEILDELRLDPVRYRTVWERAALRATVDAAHPEPPADLPAAAARFRRLHGLTGTAETQAWLDTNGIDVNHFGTLVGIEQQVEETMEQLSEMMPLAVLDVLRIDGEYAPLCQHIAAKRRALTEHGLDGSGPTADGDTTLQQLRWYFDMIGRPMPQSLESHWRPLGFVDQRDFLRAVRSEYHYRTLADRTERRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC56</accession>
    <name>F4FC56_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734706.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24780"/>
    <dbReference type="EnsemblBacteria" id="AEB46054">
        <property type="protein sequence ID" value="AEB46054"/>
        <property type="gene ID" value="VAB18032_24780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24780"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428060_0_0_11"/>
    <dbReference type="OMA" id="IATVYEM"/>
    <dbReference type="OrthoDB" id="551372at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="700" mass="78570" checksum="079958CF09C6CECD" modified="2011-06-28" version="1">MNPFLGNPAEPLYHRMWTELNRRQPAETATESPLLALGRSSDVDPLLPEQVDDARRVLLDRAALIDDGRTELRDDVLAGQRRVVERFLRGRRARFGEEQSRPLPDIDALIREGRDIFIVIKFMDEAPHLAATIDSLLHQEGIDLHRLVVVMVDNNSSDGSDAIVAKAIETNPGPARLVSLPQQMPGAGNAARLGVDTCIATVYEMCRRDQRWERLQTATIAVSDGDTVYHPDTLRSIAAIFDDSPTVDGVMPFLTYKFTAALRLFRHYRPAFAEPLRLRAAGLDPCAVPVDLATVRAHAELPRGKRRRTGDAMTVTTADGTTITVPLAGVDEHGRRFGALVDPSGRRAYLFEDRTLVLDRAPVSGFDAALVFLENGGVDRDEKWRWHTLIGHDLFLFWAFAGMGLPETMVFPDSSDALKTFRVWSFAIGGQHQLRRPGLRIATGSDYQSGRVLQAVGCCLRLGPAEVFAETETDRLIKMVRNFFHRQTVFYGETRSAALERATGLYLHMTRIQGEIEEEMRAYPDVMFEQTAFPERVLFPLRWMFQNAIRFYAHGPQQRDIVRERVLRRIFTPETVESIEREVLTEATLTELATAAFSDKQVVAEQAAERIIAAHYPEIMAFYVATLRDFCEAEQVRPEHYEWLLDGLTESRNAVVEQPQPVDPADVWSGAEFDIDVARGQVVRMHQAGGTVPAEEGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCH9</accession>
    <name>F4FCH9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c-type biogenesis protein ccsb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_05900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730979.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05900"/>
    <dbReference type="EnsemblBacteria" id="AEB42306">
        <property type="protein sequence ID" value="AEB42306"/>
        <property type="gene ID" value="VAB18032_05900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05900"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_0_0_11"/>
    <dbReference type="OMA" id="WLVMHVS"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="111"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="35023" checksum="F79C3131A7BCDDBB" modified="2011-06-28" version="1">MSALSDQLVSITTMVYLLAMIGHAVEYALGNSRTVAVTAPARELVGAAVGAGGGVVTERGTPVADPAGPAQRTARRAELAGRIGVGLTALGAALHLAGLVTRGIAAERMPWGNMYEFVLTVSFIGVVAWLVVLVKVPSLRRLGLFLTLVMVLLVATAELVLYTPIVPLVPALNSYWFIVHVSTIVFASGLFLLGAVPAVAYLMRAGYERGKRSFPYTLAKRLPAAASMERLTFVLHAFAFPIFTFAVIAGAVWAEAAWGRPWGWDPKETWSFISWVIYAGYLHARATPSVKRNLVAWLAILGFATMLMNLFGVNIFFTGLHSYADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCI0</accession>
    <name>F4FCI0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05905"/>
    <dbReference type="EnsemblBacteria" id="AEB42307">
        <property type="protein sequence ID" value="AEB42307"/>
        <property type="gene ID" value="VAB18032_05905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05905"/>
    <dbReference type="eggNOG" id="COG4129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046662_1_0_11"/>
    <dbReference type="OMA" id="HWILIGS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="344" mass="35821" checksum="BB8C33E60363601E" modified="2011-06-28" version="1">MWAAWCAFHHSLRQNRATATEPPVTSLNGVSRVTNWFRTAGGRLRDSWLLVVEVTLATTASWFVASRLLGGPHGSGDPSAFYAPAAALIVLSQARGVRLRRALRVLAGIAVGVVLGEAVVGVFGARSTAAVFVVILAAAGITVATGAPGVVRNQLTTSALFLVAVVPPGQELDSRTAALRRAVSVVDENLRLAVWERGSRSRVDAARSAADHVDYAVRNTRTLARSTVVLARLPQPPPPQFATALAGLSRLAGCAAAVLTAVVAGDGDTADRHVDRAGAVALDAVRAMTPLVRHEQPLPVSTIVGHIRMVTVDLLRSAGADKPDVLDAIDAALALPGAHRTGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCP9</accession>
    <name>F4FCP9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cys_rich_CPCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732212.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12145"/>
    <dbReference type="EnsemblBacteria" id="AEB43543">
        <property type="protein sequence ID" value="AEB43543"/>
        <property type="gene ID" value="VAB18032_12145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12145"/>
    <dbReference type="eggNOG" id="ENOG50334NU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161873_1_0_11"/>
    <dbReference type="OMA" id="SKERCAC"/>
    <dbReference type="OrthoDB" id="1977738at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025983">
        <property type="entry name" value="Cys_rich_CPCC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14206">
        <property type="entry name" value="Cys_rich_CPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cys_rich_CPCC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="80" mass="8597" checksum="FF88DA570AB53B4F" modified="2011-06-28" version="1">MEERWVPAACPCCASRTGGGTCPVCFWTDDGQADADADVVRGGPNGDLSLTMARLNFAVYGACHPRYQDAVRPPRPEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD20</accession>
    <name>F4FD20_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733507.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18750"/>
    <dbReference type="EnsemblBacteria" id="AEB44852">
        <property type="protein sequence ID" value="AEB44852"/>
        <property type="gene ID" value="VAB18032_18750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18750"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_3_11"/>
    <dbReference type="OMA" id="SDLWMQI"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="278"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="531" mass="56425" checksum="24EBEB9DEDE3ECDC" modified="2011-06-28" version="1">MAATAPQVLAIDLGTSALKAALVAADGTVTGWAERSLPLRVLPGGGAEQDPAHWWAALGAVAADLGRAHPDQMRAVATVCASTQGEGTIAVDAAGEPLTPCISWLDMRGAPHLRRQFRGFPAYQGMSVRRIARWLRLTGGMPSPTGKDPAAHMLFVRDELPQVYARTAAFLNVLDWINLRLTGRTVATVDSILTSWVTDNRRPGDIRYSPALVADCGIDADKLPPIVACTEVLGPLTPAAAAHLGLPESVQVVAGAIDTTAAAIGAGTTGDRQAHLYLGTSSWIAAHVPGKKTDVVAGIASVPCAIGDRYLMTALQATAGANLTWLRDKVVEYDDPLLGAGHVSRDEGSIFDAFDMIIPTVPPGANGVLYTPWLYGERAPVDDAHLRAGFLNISLDTSRSDLLRAVFEGVALNTRWLAAAVDRFLGAPVTSLAITGGGALSDSWCQIFADVLGVQIRRDAQPLAVNARGAGWIGAVGAGRLDFADIPDLMRTDRVFAPTPEHRATYDEVFAVYRDLHQRLAPVYRRLNRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD49</accession>
    <name>F4FD49_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734731.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24905"/>
    <dbReference type="EnsemblBacteria" id="AEB46079">
        <property type="protein sequence ID" value="AEB46079"/>
        <property type="gene ID" value="VAB18032_24905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24905"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_11"/>
    <dbReference type="OMA" id="VMDLYPC"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="522"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="603" mass="63721" checksum="BB6944372884EB31" modified="2011-06-28" version="1">MTSALINAPVAEPTVAAAADLLDRLADVPADRVAVVHGDTSLTFGQLRERVGVVAGRLAARGVGPESVVALGLPRGVDLVAALLGTMTAGAAYLPVDPQLPVDRRRYLVDDARADLLIVDGDTEPLTASTPQVSLAALTTPDDTPTGGYAPVPVGPATLAYVIYTSGSTGRPKGVEISRGALASLLTELESTGVVRPGPGAVGWNASPSFDASVQQWIRLCRGDTVVLLDEQTRTDPALLGALVEQHPLTDLDITPSHLELLLEHLAASPRGAEGRPLTLIVGGEPISPTLWGRLGELVDAGILRAVNAYGPTECTVDATVGRITSDRAPHIGTVLPGLRLRVLDDALAPVTPGEVGELYLAGSRVGRGYRRRPGLTAERFVADLDSDDGTRMYRTGDRCRQLPDGRLEFLGRVDSQVKVRGHRMELGEIESVVGAHPAVAETAVLVHEEDGQLLVAYYRPSAPVDAAALREWTARSLPGYMVPGAFVAVDRFPRTNSGKLDRAALPAPTLTPAPQVPTGVSPTGPVEELIARVWSQVLRQPSISAEDNFFKLGGHSLLAIKLVSRVRAELGLSLPIRAVYENPRLRDLARAIEARLEPSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDA2</accession>
    <name>F4FDA2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_25170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734784.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25170"/>
    <dbReference type="EnsemblBacteria" id="AEB46132">
        <property type="protein sequence ID" value="AEB46132"/>
        <property type="gene ID" value="VAB18032_25170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25170"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="SPKAFLM"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="400" mass="43685" checksum="DD9DA17135C5F936" modified="2011-06-28" version="1">MADIVLDKVSKKFPDGTTAVRDVDLEIADGEFVILVGPSGCGKSTTLNMIAGLEDISSGELRIGGQRVNDKAPRDRDIAMVFQSYALYPNMTVRENMAFPLRLAKLDRATIDQKVEEAAKVLELTSLLDRKPANLSGGQRQRVAMGRAIVRQPKAFLMDEPLSNLDAKLRVQMRTVVSRLQKQLGTTTVYVTHDQTEAMTLGDRVVIMRGGAIQQVGPPQELYDHPNNLFVAGFIGSPSMNFLPATVEEGRLRTALGDLPIGDRIRRELEGADAPRELILGIRPEHFEDAELVDEQTRDRGMEFTAPVDIVESMGSDKYVYLTVEGGRASAAELEELAADAGAADLAGSNLVTRLSAESTVTEGEDRRVWFNLEKLHLFDPSNGRNLTLHEGRSAGALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDG6</accession>
    <name>F4FDG6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47377">
        <property type="protein sequence ID" value="AEB47377"/>
        <property type="gene ID" value="VAB18032_01465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01465"/>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055269_1_1_11"/>
    <dbReference type="OMA" id="VHDKPMH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="333" mass="34527" checksum="3A4C894CE080CCF2" modified="2011-06-28" version="1">MLGSVRGDEKQAEQGDLPEAAVAVGDGDLAAAAPDGGTVRLALVVGGLVLAVLLGFGLGRINSGGAVAASGPLDSALTGHTHAPGTGAHSHEAGQAEATEAGGLAVSRAGYTLVPLSAEFTAGQAGELRFRIQDGQRRPVTRFAVVHDKPMHVIVVRRDLSGYQHLHPTMAADGTWSVPLTLPQPGIWRAYADFTALAGDGRQTATTLGVDLVAPGAYAPRALPDPAPSTTVDELTVGYQGSPEPGLTVPVSFRVTDADGSSPTLEHYLGTFGHLVALREGDLGYLHVHPEPELVDGAIQFWLTTPGPGRYRLYLDFATGGVVRTAEFTVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDI9</accession>
    <name>F4FDI9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="8" type="ordered locus">VAB18032_06140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731025.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06140"/>
    <dbReference type="EnsemblBacteria" id="AEB42352">
        <property type="protein sequence ID" value="AEB42352"/>
        <property type="gene ID" value="VAB18032_06140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06140"/>
    <dbReference type="eggNOG" id="COG1005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_0_11"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="448" mass="49186" checksum="DF7F47D581988CB1" modified="2011-06-28" version="1">MNPLAQPPSLTDFGHDPWWLILGKVVFAFVVALLGTLLGVWFERRVVGRMAVRPGPNQLGPFGLLQTLADGLKMAFKEDILPKAADKVIYFIAPAISMICAVTMLSVIPFGPMVSIFGHQTPLQVTDVSVSVLVVLALSSMAVYGIVLAGWASGSTYPLLGGLRSTAQLISYEVSLGLSIVAVFMLAGTMSTSEIVAAQGQGVTLNLFGAELPGPGWFALLLFPSFVVFLISIVGETNRPPFDMPEAESELVAGFMTEYSSLKFALIMLSEYVAMVAMSAFTVTLFLGGWYAPWPISIWSGANSGWWPLLWFFAKVILLVFVFVWLRGTLPRLRYDQLMRLGWKVLIPVSLVWIVFLATWLKVQDWERNDRLVVFGILGGIALIAALFWPNRKPEQKPTVAEQVENRPQGSFPLPPMDLQVPPSPRTRRMVAEREPANAPAGQDSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDY9</accession>
    <name>F4FDY9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732338.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12780"/>
    <dbReference type="EnsemblBacteria" id="AEB43670">
        <property type="protein sequence ID" value="AEB43670"/>
        <property type="gene ID" value="VAB18032_12780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12780"/>
    <dbReference type="eggNOG" id="COG3285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_1_0_11"/>
    <dbReference type="OMA" id="TTAWWKE"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="341" mass="38089" checksum="C055C06BE2D116CA" modified="2011-06-28" version="1">MAGTKAAAEEIEVAGHTVRLSSPDRVIFPKRGFTKADVFGYYLGVGDGIMRALRERPTTLQRFPDGIEGEMFFSKRVPTRGVPPWVRTTEITFPSGRTAAELCPVDLAHVAWAAQMGTVVFHPWPVRAAEPDRPDELRVDLDPQPGTDFAHAATAAGELHVILDELGVPGWPKTSGGRGVHVYLRIQPRWSFVEVRRATIALARELARRRPDLVTTAWWKEERGERVFVDYNQMARDRTIACAYSLRANARATVSTPVTWDELPDVDPDDFDLRTVPQRLAEQGDPHAGIDDAGWDITPLLEWAERDAAAGEGDLPYPPDHPKMPGEPKRVQPSRDRDRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEF1</accession>
    <name>F4FEF1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734869.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25595"/>
    <dbReference type="EnsemblBacteria" id="AEB46217">
        <property type="protein sequence ID" value="AEB46217"/>
        <property type="gene ID" value="VAB18032_25595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25595"/>
    <dbReference type="eggNOG" id="COG1585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116732_2_0_11"/>
    <dbReference type="OMA" id="AMPEFGM"/>
    <dbReference type="OrthoDB" id="1951939at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="16235" checksum="BABCD21441E3C6F9" modified="2011-06-28" version="1">MDAVFWIVLGVVLAVAEIFTATLFLIMFAVGAFAAAGAAALGAPVAVQAVVFAAVSALTVLAARPVIQRHKQSAMESGDTAFGIEAIEGSTALVLEQVDSDKGMVKIDGEVWSARAYDATQVLVPGERVQVIQVKGAVALVWRDVATPAELPEAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEL9</accession>
    <name>F4FEL9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_01885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736095.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01885"/>
    <dbReference type="EnsemblBacteria" id="AEB47461">
        <property type="protein sequence ID" value="AEB47461"/>
        <property type="gene ID" value="VAB18032_01885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01885"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="OMA" id="IDRVWGS"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="25257" checksum="00A31E5068C6F121" modified="2011-06-28" version="1">MSRVLVVEDEESFSDALSYMLRKEGFEVSVAATGTSALTEFDRAGADIVLLDLMLPEMSGTEVCRQLRQRSHVPIIMVTARDSEIDKVVGLEIGADDYVTKPYSPRELVARIRAVLRRQSPETVESGTATLAAGPVRMDIERHVVTVDGSTVQLPLKEFELLELLLRNAGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEPEPSSPRHIVTVRGLGYKFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEN7</accession>
    <name>F4FEN7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06535"/>
    <dbReference type="EnsemblBacteria" id="AEB42431">
        <property type="protein sequence ID" value="AEB42431"/>
        <property type="gene ID" value="VAB18032_06535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06535"/>
    <dbReference type="eggNOG" id="ENOG5032YNH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_1_0_11"/>
    <dbReference type="OMA" id="PWQGDPR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="81" mass="9292" checksum="FC54F77070B15844" modified="2011-06-28" version="1">MPSIDKLVAAMRKSQQNIAYNDLYRVCEHFFGKPRQAGTSHAVFKMPWAGDPRVNIQNDKGKAKVYQVRQVLRAIDKKEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEZ7</accession>
    <name>F4FEZ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732377.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12975"/>
    <dbReference type="EnsemblBacteria" id="AEB43709">
        <property type="protein sequence ID" value="AEB43709"/>
        <property type="gene ID" value="VAB18032_12975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12975"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_0_11"/>
    <dbReference type="OMA" id="VDPLCGT"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="28316" checksum="596D52C72D040CE6" modified="2011-06-28" version="1">MPISDEELVVAAAEAGAAVVRSHYGSALTHFPKSAGDFATTADVEAEAAILDVLHSARPNDLFVGEESGRTGTGVSGRVWFVDPLCGTLNFAVRNMLAAVNVALRVGEQVTVAASADPFSHEVFWTDGAGAYLRHRGVDQRLDPSSESRLVDVNLDPPFPNIDVFSAARLLADQSFIDTFRPRVVSTTLAVAWVAAGRRAAYVTDGQLRDNVHFAAGIAVCQAAGCVVTGIDGRPLHTGLGGLVVAADEPTHAALLTLVRDQCARSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF02</accession>
    <name>F4FF02_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bioD</name>
        <name evidence="6" type="ordered locus">VAB18032_13000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732382.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13000"/>
    <dbReference type="EnsemblBacteria" id="AEB43714">
        <property type="protein sequence ID" value="AEB43714"/>
        <property type="gene ID" value="VAB18032_13000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13000"/>
    <dbReference type="eggNOG" id="COG0132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072551_1_0_11"/>
    <dbReference type="OMA" id="SPHWAAE"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="245" mass="25145" checksum="C0FE1710BB36FC19" modified="2011-06-28" version="1">MCAMTDQWRGPVLVTGTDTEVGKTVVTAAITAAAQAAGLRVAVVKPGQTGTATGEPGDVEAVTRLAAPMTGRTLASFPDPLAPLVAARVAELPPLELYNAVDAIRDEADKHDLVLVEGAGGLLVPMGVRPSGEPWTVADLAVSLGAPAVVVARAGLGTLNHTALTLEALDRRAVPAGVVIGAWPADPELVHWANLSDLLPNLLGALPAGAGAMDPGVFRRSAPGWLTPALYGVLDDWRAWADEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF28</accession>
    <name>F4FF28_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732408.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13130"/>
    <dbReference type="EnsemblBacteria" id="AEB43740">
        <property type="protein sequence ID" value="AEB43740"/>
        <property type="gene ID" value="VAB18032_13130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13130"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OMA" id="HAFNWAA"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="146"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="27880" checksum="4EBDD7A806FAC2A2" modified="2011-06-28" version="1">MASTNDAPVLAGIGPDDALPVARVAARVAAGHGCGVHLLHAFNWAAMAAPAVSGSRADAERLIAEASEAVRLSQPKVPITTEIVEGPAVANLVRKSESAFLVAVGDGGMAHCDRCIPADSPAVQVAARADCPVLVVRREPPPQGPVLVGVDGSASAETALAWAVAAAKELQARLMAVWVVDTDDAIEAATQRLGDLVARVSADETAVECHVVRGEPGSVLVDQSRSAQLTVVAARGDEPWRGMLGAVSQAVLYHAPSPVIVVRGVTGGPDADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFB8</accession>
    <name>F4FFB8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-mannanase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733678.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19605"/>
    <dbReference type="EnsemblBacteria" id="AEB45023">
        <property type="protein sequence ID" value="AEB45023"/>
        <property type="gene ID" value="VAB18032_19605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19605"/>
    <dbReference type="eggNOG" id="COG4124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038234_1_0_11"/>
    <dbReference type="OMA" id="AKYMWSP"/>
    <dbReference type="OrthoDB" id="669354at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309316" evidence="6">
        <location>
            <begin position="25"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="7">
        <location>
            <begin position="45"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="376" mass="42071" checksum="5172332B2015F873" modified="2011-06-28" version="1">MARLTLPRVAMSLVGALLLAYAFAIAPGTGSGRRESAPADQAAVREPSPSPSPPEVFPPAEKVFIGIATKEGPHDFTPVDAFTATAKHHPQVMLFGSGWATDTFDRTLFDAVSSRGMLPMLAWEPWDYRLDEQARKKGAARGTIDRLRSRQPDYRLSHITRGDFDDYLRSWAEGIKALDYPVAIRFAHEMNGNWYPWCETANGNQPGDYVKAWRHLHDLFMAAGTTNVIWVWSPNARWDGSTPKLSALYPGDDYVDWIGISGYYGMGAFSKYRSFDAIFKETIGEIRAFSAKPLVITETAASDIAGRKAEWITETFRSLPEHEGIIGLIWFEVNKERDWRIVSSPAVSAAFAQAVSDPRYRFTWSPEMLPRTEPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFD6</accession>
    <name>F4FFD6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734890.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25700"/>
    <dbReference type="EnsemblBacteria" id="AEB46238">
        <property type="protein sequence ID" value="AEB46238"/>
        <property type="gene ID" value="VAB18032_25700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25700"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056342_5_2_11"/>
    <dbReference type="OMA" id="NVGPGHT"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="29568" checksum="65C99DB692339AB5" modified="2011-06-28" version="1">MSGSFVEVADRVLVLREPLLAVNVTLVLGDGEALLVDTLSTVGQAVELRAAVRAVTGDPLTLVNTHHHFDHCFGNAALAGDPPRPIWAHELAATALCDDPERLRREAYAELRDEHPELADELAEVTVLAPTHTVHTEATLDIGGRQVVLRHPGRGHTDADLVVHVPDADVLVAGDLVEQSGPPAFEDSYPLQWPEAVAELLRWTTDSTVVVPGHGTPVDTEFVRAQHAQLVELAWLIRAGHTGSTPPERVAADAPFPARPALLAAHRGYAELDGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFT2</accession>
    <name>F4FFT2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EmrB/QacA family drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_06940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731185.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06940"/>
    <dbReference type="EnsemblBacteria" id="AEB42512">
        <property type="protein sequence ID" value="AEB42512"/>
        <property type="gene ID" value="VAB18032_06940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06940"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OMA" id="LEWRPIF"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="34"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="564" mass="59259" checksum="AA44CF1F7F7BE0DF" modified="2011-06-28" version="1">MTPSRTRPSPSPAETPADPPAQPAPIAGRARTIALVAVLVGLLLDLLDIVIVNVALPTIQEEIGASSSDMQWMVGGYTLAFATMLVTGGRLGDIYGRKKIFIIGMVGFAAASLVAGIAANPEQLIVARFVQGGMGALMVPQVLSILQVMYPPQERGRAFSALSVVFAVGTVAGPIVGALLTAVDIAGLTWRTIFLVNLPIAAVCLFITVKLVPESKGESAQRLDVKGAILVGLGMLLLVFPLIQGPEQGWPAWTLISLVASLLAFAALVAVQRRQTESPLIPISLFSHRSFRGGLAVSLLFMSGVMPFFLVNTLYLQFGQGFSVIKAGLIGVLWGFAVPLFTAISARHITPKLGRLGLQLGLVMLIAAMVILITVIHQFDTITPWALAPGLILGGAGMGMTFAPLLTYTLNDVPLHSAGAASGVFNTVQQMGAAIGIALSSMVFFIALAVQSPAVGDDLRNTVKEELSARGVPVAAVDAAADSARACFDERIKAANPEADVAACRAVASQSGADVADRHDELQFIANRTAYQQTTVRALVYQIVVFTLAIAASFLLPRRVEHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFT5</accession>
    <name>F4FFT5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731188.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06955"/>
    <dbReference type="EnsemblBacteria" id="AEB42515">
        <property type="protein sequence ID" value="AEB42515"/>
        <property type="gene ID" value="VAB18032_06955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06955"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_2_0_11"/>
    <dbReference type="OMA" id="TWKFASG"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="226"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="378" mass="39219" checksum="981057D4578BCDC1" modified="2011-06-28" version="1">MTTLQLVRDLLPEIAKNADEVERGRGLPDHLLDGLRTAGCLRMLAPVAYGGTGLNVPETLRVVETLGTADASVAWLVGQVALSQLIIGCAPKETVAEIFADGPDVYAAGAVAPKGRATEVDGGWRISGQWPFVTGCERAAWVYLNCVLVRGRTVAMAEGRPATRIMLLPAADVAVVDTWHTLGLRGTGSHDLAVSGRYCPAERAVELVPGSAEAARAAMSIAQSSLIIAAAALGIAEAALRDVVDLAAGGKRPALSATRLASSTAFQERLGEARMVVQAGRALLYDQAGDEWGGFSGPDAALRRAQVRAASAQATALAVRATDAAFELAGGTAVYDSSPLSRRLRDANTARQHFVASRNSYTAFGAHLVGEGGDGGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFW4</accession>
    <name>F4FFW4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731217.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07100"/>
    <dbReference type="EnsemblBacteria" id="AEB42544">
        <property type="protein sequence ID" value="AEB42544"/>
        <property type="gene ID" value="VAB18032_07100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07100"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_3_2_11"/>
    <dbReference type="OMA" id="FYGFGYS"/>
    <dbReference type="OrthoDB" id="1087129at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="29"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="469" mass="51898" checksum="E5991D699CCE219A" modified="2011-06-28" version="1">MAQLSTEVYWHSTEPTEVGPPLDGDASCDVCIVGAGYTGLWAAHFLKQAEPGMSVRVVEAKFAGEGASGMNAGFVQMTAGKVLRRMLWYYGAEKAGGVYRAVARSILEIGRFCRQNGIDAQYENTGILQVATDTKQLARLELQIKRAQRAGVTSFRLLDREQAQERIGSPTVLGALKVSGALLNPYRLVRGLARVVQEQGVLLHEQTPAQTIEKVDGKWRITTPHGTITANEVIVATEAMQGAFPELYARQMPVWNYLLVTEPLTDEQLGRVPWPGREGVANSLSFSTAARLTADNRVLWAGGLWYMFGNRDTDPRHRRNDDAFDKLGASFREFFPQWRDVRFSHGNGGLISWSHSFIPQFGRTDSGMVYGHGYTGSGIAASHTGGKILRDLVLRRKTEFTELAFVTVNQPKFLPAPFGDKGGEFFIWRQRVGDRLPLLLPYKSALAPNRFFARRTGSPERATAGRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFY6</accession>
    <name>F4FFY6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731239.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07210"/>
    <dbReference type="EnsemblBacteria" id="AEB42566">
        <property type="protein sequence ID" value="AEB42566"/>
        <property type="gene ID" value="VAB18032_07210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07210"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_5_0_11"/>
    <dbReference type="OMA" id="AWCPYCN"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="47"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="25242" checksum="F5D95E417615FB29" modified="2011-06-28" version="1">MSLNERLREYKARQEAGEVPPITSAHLEVIYREAEALAASGAEDRVLKVGDPFPSFELPDENGDVVSSADLLSRGPLAVVFYRGIWCDYCNFELEALEEVYPQIRELGAELVAVSPVTMPNLRAAIRRNKISYRILSDRGNTYAARFNLTYTMNQALLDVWGSFGMDFSQINGDDSNRMTMPGVFLADTDGVLRFASAYARHWERTEPADLIAAIERLSPQNAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFZ2</accession>
    <name>F4FFZ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_07240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731245.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07240"/>
    <dbReference type="EnsemblBacteria" id="AEB42572">
        <property type="protein sequence ID" value="AEB42572"/>
        <property type="gene ID" value="VAB18032_07240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07240"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="DNMFMGR"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="268" mass="28740" checksum="799EC1DD24408CA8" modified="2011-06-28" version="1">MSAATQNAGTSGGATGTNAPPLQLRGIRKQFGGVVAIERFDLELAAGEITALVGDNGAGKSTLVKIISGVYQPTEGELRMHGRPVSFRDASDARRQGVEVVYQDLALADSQPVYMNMFLGRELTRGPLRLLDRRRMARETQALVDALDVRIPSAKAIIRDLSGGQRQAVAICRATHWASGLVLMDEPTAALGVAETAKVEELILKLRERGAAVLVVSHNLDQVFRIADRVAVLRRGRQVGVRSIEDTSRNEIVSMITGASAPDESSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG77</accession>
    <name>F4FG77_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Fe4-S4 ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_13545</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13545"/>
    <dbReference type="EnsemblBacteria" id="AEB43821">
        <property type="protein sequence ID" value="AEB43821"/>
        <property type="gene ID" value="VAB18032_13545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13545"/>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027059_1_0_11"/>
    <dbReference type="OMA" id="HCPVYDK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="LUD_dom" evidence="8">
        <location>
            <begin position="85"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="326"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3390" evidence="9">
        <location>
            <begin position="403"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="476" mass="51108" checksum="CD7B01AA000B4E45" modified="2011-06-28" version="1">MTHTFLGMPSTAPPGVGHLRGTEPFPSAARRSLADPQLRRNLGHATATIRARSAGMIAEVPDWQQLREAGRAIKTDVLARLPELLEQLEERVTEAGAVVHWAADATEANRLVTDLVRATGSERVIKVKSMVTQEIGLNEALVAAGIAPVETDLAELIVQLGDDRPSHILVPAIHRNRAEIREIFLRAMPGVDPGLSDEPAALAAAARGYLRQTFLTTKVAVSGANFAVAQTGTLAVVESEGNGRMCLTLPETLITVMGIEKVVPTWQDLEVFLQLLPRASTGERMNPYTSMWTGVTPGDGPQAFHLVLLDNGRSAVLADPTGRRALHCIRCSACLNVCPVYERTGGHAYGSVYPGPIGAVLSPQLTGVADNASLPYASSLCGACYDACPVMINIPELLVQLRDQAPHPRAEAAAMAAAAYTMDHPRLYEAAQRAVRLSRLAGRRGRALPPPLDGWAASRDLPDPPSQTFRQWWAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGP8</accession>
    <name>F4FGP8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736191.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02370"/>
    <dbReference type="EnsemblBacteria" id="AEB47558">
        <property type="protein sequence ID" value="AEB47558"/>
        <property type="gene ID" value="VAB18032_02370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02370"/>
    <dbReference type="eggNOG" id="ENOG5032SVJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108860_0_0_11"/>
    <dbReference type="OMA" id="HPGAKEQ"/>
    <dbReference type="OrthoDB" id="2048400at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="129" mass="14060" checksum="105B528C4D5CA08A" modified="2011-06-28" version="1">MSPADATPTAESPDARVSTSAGADTAAVPPPRSAPDDESLPPSTPDAVTAEATDTLADREREILAFERQWWRHAGAKEQAIRDRFGLSATRYYQLLNALLDNPAALAADPVLVGRLRRLRASRARNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH94</accession>
    <name>F4FH94_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cdp-glycerol:poly(Glycerophosphate) glycerophosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732539.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13800"/>
    <dbReference type="EnsemblBacteria" id="AEB43872">
        <property type="protein sequence ID" value="AEB43872"/>
        <property type="gene ID" value="VAB18032_13800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13800"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_3_11"/>
    <dbReference type="OMA" id="RTYCAII"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="377" mass="42700" checksum="1FE3689292CC8124" modified="2011-06-28" version="1">MVNQPTQAPLLSIVVPVYGVEAYLRQCLDSIREDVPANETAAVELIAVDDASPDGCGQLLREYAAEHPGLRVLHLERNVGLGPARNAGLDVATGEYVWFVDSDDWLPPGTIAAMLDRLRTDRPDVMMIDHLRVHECGRRDIDASSHLLRGTPGVVRLVDRPQLLRVQHTAWNKVVRRAFMAELGLRFHPGWYEDIPFSHPLLIGADRISVLDRICYLYRQGRQGAITSTRSGRHFDAFDQYDRLFAWLRQHHPDGRWHAELFDLMVNHFLVVVGNDDRLHPHLRRRFFRRVAAHYRRHLPGGGYPRPGGVAGLKHRLVDRNNYLAYVALRRAHRLADRLRSPSAPPPATTSPDADHDAGSDPTRPRTLVRTHGNGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHD0</accession>
    <name>F4FHD0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_13980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732575.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13980"/>
    <dbReference type="EnsemblBacteria" id="AEB43908">
        <property type="protein sequence ID" value="AEB43908"/>
        <property type="gene ID" value="VAB18032_13980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13980"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616683_0_0_11"/>
    <dbReference type="OMA" id="RAFRISM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="340"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="444" mass="46549" checksum="A8B48802C7BD82B0" modified="2011-06-28" version="1">MTQLSRLATAVRQIRDDRVVRTAGGLIGSQIVIAVVSFAISLLSARVLGPTGRGELALYVLLAQVACVFCVLGAEQAYPAALTARPGVQQAGREVWRLVRWSTLLVVTAVASAIVIKNGATGNAWLLCLGFMLYVTGLVLLRVLTAASAAASSARRQLAVVVVWQLALLPVGGLLALLEVQSPGLWLCLFGATGVLPLAVVVFGRRAGRPQEQPGPDLSRARALGLRLIPATITNLLLLRAERFLIPWLASLAELGIYVVVATLTELIDLPMRYLLRAMAPDLADQIRTGRLRHRRILLIGLAYGVGGGSAVGVVVGIVLVPLFGAEYAGAVNLALPLGLAAGIYSFSRVGATICVAAHMPHLNTMMDLFGLVASVVGCLLLIPGHGATGATIATLVAYCLVAVVSVWCVRVVVRQIEARANHIDSPKGGPDSAAVRDKTSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHD5</accession>
    <name>F4FHD5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733762.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20025"/>
    <dbReference type="EnsemblBacteria" id="AEB45107">
        <property type="protein sequence ID" value="AEB45107"/>
        <property type="gene ID" value="VAB18032_20025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20025"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="GRICIPY"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="21664" checksum="5945D70FE234B77C" modified="2011-06-28" version="1">MIRILLAEDMHMVRGALVALLSLEPDLEVVAEVAEGTAILPNALTHRPDVAVLDIGLPGIDGLAAAGALSQQLPTCRTIMLTSHADSANIARAMLIGVSGFLPKDAPPTRLADAIRRVHRGERVIDSEIVVAAFHHGPNPLTERERDVLTHVAKGSDVSDVAAKLYLAPGTVRNYLSAIMSKIGARNRVDAIRIARDRGWISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHF1</accession>
    <name>F4FHF1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ion transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_20105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20105"/>
    <dbReference type="EnsemblBacteria" id="AEB45123">
        <property type="protein sequence ID" value="AEB45123"/>
        <property type="gene ID" value="VAB18032_20105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20105"/>
    <dbReference type="eggNOG" id="ENOG502Z7ZD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055047_0_0_11"/>
    <dbReference type="OMA" id="IFTIENW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="PTHR10037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="7">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="322" mass="35347" checksum="B2810DA5D1000E87" modified="2011-06-28" version="1">MARTVRSPLRRLAARCQAVVGASWFNLASFAVVIVNAMALGLETYGGVVAIVGTALRTVEYACLTLFVLELLVRFGAHALAPGGFLRDRWNVFDLVIVVAPLLPGVRENVTLLRLLRLARIVRAFRLFPSLRVILVGIRRSLPGLASFLLVTALLLYGYAMLGWMLFGVAYPQEYGSVGQAMLTLFLLLSLDGITDTLQAGREVTGWAVLYYVSYMVAACYLLTNLLVGLVLTALQEAHQDEQVAAQRSDRPPGGHAEDEPSVREQLARVQAIITDLERRLPEQELIGPPATGRVTAEAGTLVLSKPRVSQRSRARGRRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHI1</accession>
    <name>F4FHI1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IucA/IucC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733808.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20265"/>
    <dbReference type="EnsemblBacteria" id="AEB45153">
        <property type="protein sequence ID" value="AEB45153"/>
        <property type="gene ID" value="VAB18032_20265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20265"/>
    <dbReference type="eggNOG" id="COG4264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018524_1_1_11"/>
    <dbReference type="OMA" id="HPWQWWN"/>
    <dbReference type="OrthoDB" id="856726at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="2">
        <location>
            <begin position="144"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="3">
        <location>
            <begin position="416"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="598" mass="67144" checksum="E077372CFCECF2D1" modified="2011-06-28" version="1">MTTTDPVAHLRPQTWERANRLLVRKALAEFAHERLITPEPDGLAAGGRRWYTVTSDCGTVRYRFTARLRTLEHWDIDPESITRQRDGQPQPLDAVDLCLDLRTSLGLTDRILPVYLEEISSTLAGSAYKLDRALPSAAKLIEADFQTIETSMTEGHPCFVANNGRLGFGVDEYHSYAPEAARPVRLIWLAAHRDHATFTSAADLDYDTLLRTELGEATLARFAETMAALDLDLADYLLIPVHPWQWWNKLSVTFAGEVARRRLVHLGESDDDYLAQQSIRTFFNVSAPHRHYVKTSLSVLNMGFMRGLSAAYMEATPAINDWLADLITADEVFQATGLTIIRERAAVGYRNRQYEAATDRYSPYRKMLAALWRESPVPTLAPGERLATMASLLHVDADGRSFAAELITASGLAPAQWLRRYLHAYLTPLLHAFYAYDLAFMPHGENVILVLRDHAVQRVIFKDIAEEIVVMNTEAALPPAVERIRAEVPEEMKLLSIFTDVFDCFFRFLGATLADQGIADEETFWRTVADCATDYAARVPHLADRLARYDLFAPEFALSCLNRLQLRDNQQMVDLADPSAALQLVGALTNPLARHAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHI2</accession>
    <name>F4FHI2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase ECF-subfamily sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_20270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20270"/>
    <dbReference type="EnsemblBacteria" id="AEB45154">
        <property type="protein sequence ID" value="AEB45154"/>
        <property type="gene ID" value="VAB18032_20270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20270"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_2_11"/>
    <dbReference type="OMA" id="HEHADSE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="21944" checksum="55C5FDCCB3C782DC" modified="2011-06-28" version="1">MTAQLRRRIRAGDTDAFGELFDEHADAVHRHAVWSEGDPVLAEDVVSLTFLEAWRIRESLRPDGESLRPWLLGIATNVLRNRRRAARRHRAALRRLPVRDTVPDFADDVVGRMHDADQLAAAVAALRALRRADREVFLLCVWSQLDYAAAAEALGVPVGTVRSRLSRARTRLRALAQQELDRPRGTPVEQGEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHK7</accession>
    <name>F4FHK7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733834.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20395"/>
    <dbReference type="EnsemblBacteria" id="AEB45179">
        <property type="protein sequence ID" value="AEB45179"/>
        <property type="gene ID" value="VAB18032_20395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20395"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046680_0_0_11"/>
    <dbReference type="OMA" id="LGMRYSA"/>
    <dbReference type="OrthoDB" id="595291at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004729">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01319">
        <property type="entry name" value="glmL_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="443" mass="45046" checksum="1672485C45D6695E" modified="2011-06-28" version="1">MRVAVCADVGSTFTKVLVVDLDGGGLVASASARTSVDTDVLHGLEAAVGSALTGLGARDVPWFVCSSAGGGLRLAVVGYEPLVTAQAGRRVGLSAGANVVHVAAGRLGRGELTALRAARADVVLLVGGTDGGDAETLLHNATRLARARLRVPVVVAGNGDVRDEVQGLLAAAGVPVTVADNVLPRIGVLAPTSAREAIRQVFLRHVIGGKRLSRGRRFAGLVRAATPDAVLTGVEALAEVAGGDLVVVDVGGATTDVYSVLTPDERASGPGREVAGSLWRARTVEGDLGMRWSAPGVVRAAIEERLVGPVEADELESAAARRAADAGFLPADAAGRAVDARIAELAATVAVRRHARGVGTGERSGRDLRDVRLLVGSGGVLRHARDNEAGGVLDAVLTDHAGGWAVPRAARPVVDVDYVLAAAGLLVGEYPVAARGLLRSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI60</accession>
    <name>F4FI60_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30304"/>
    <dbReference type="EnsemblBacteria" id="AEB48024">
        <property type="protein sequence ID" value="AEB48024"/>
        <property type="gene ID" value="VAB18032_30304"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30304"/>
    <dbReference type="eggNOG" id="ENOG5031WCF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1776694_0_0_11"/>
    <dbReference type="OMA" id="WWADLAP"/>
    <dbReference type="OrthoDB" id="2095236at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="146" mass="15499" checksum="166129EA1F11DEC4" modified="2011-06-28" version="1">MPAPDRSGPVYPTTGDVVESPPPGESPGRDDHGDDELTASPPPAAQASRIAARFARAWVRSDLPADEWWRQVAEVCDDGFAEQLRTVDPGRVPATRMDGEPVASKPPKGGAAEYEFATDSGTLTVTVVALAGRWLVTGADFRRTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F143</accession>
    <name>F4F143_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731370.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42697">
        <property type="protein sequence ID" value="AEB42697"/>
        <property type="gene ID" value="VAB18032_07895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07895"/>
    <dbReference type="eggNOG" id="ENOG5033GMA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1524493_0_0_11"/>
    <dbReference type="OrthoDB" id="1482293at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="19111" checksum="D12A2EAE32F0F4CB" modified="2011-06-28" version="1">MLDPRRHYASLRLVALLPLVLFLPAVIAFFVDPDVAWGEYLGVFFHLSILFLVSRLPAAPWAKAAGYGWVTLDVLAGILMINAVEYDTAWAVRLGGHVLAGVWIVASSLVSHSWPVRVVGVLTGLWLAGYSFVGTVLAEEFLRPAGILILAWFALLGIFHRDEPGHPATPTSLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1B1</accession>
    <name>F4F1B1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14175"/>
    <dbReference type="EnsemblBacteria" id="AEB43947">
        <property type="protein sequence ID" value="AEB43947"/>
        <property type="gene ID" value="VAB18032_14175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14175"/>
    <dbReference type="eggNOG" id="ENOG50332K7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080168_2_0_11"/>
    <dbReference type="OMA" id="LWSAGPR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="22150" checksum="D279A7FC4A80FFE8" modified="2011-06-28" version="1">MLIADEFFLIAHNDIRGRAKLHPAATGLGLAGGLLGELILYGHITVANGQVGVIDRRPPADALAHTVLDQLIGEAQHQSVRTWLSFLAQTAVTAVGERLARAGALRRQESRRLLRTTVSYVPIDPNVAAWPATRLRAVLERPDPPSVPDALLLGLVASAGLTREVLWSAGPRAHHRLNLIIPALPAPLKELVAHTEAAVGAAVLRGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1G4</accession>
    <name>F4F1G4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20465"/>
    <dbReference type="EnsemblBacteria" id="AEB45193">
        <property type="protein sequence ID" value="AEB45193"/>
        <property type="gene ID" value="VAB18032_20465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20465"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_9_3_11"/>
    <dbReference type="OMA" id="MVMMAIE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="161"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="318" mass="32112" checksum="5411D567A7EC6703" modified="2011-06-28" version="1">MGAALCLLSAACFGAMAIFGKLAYDAGVSPGALLLVRFSLAAVLLGMVLLVRPGLRHAGARTVGAAGRAPMRRGRVLAVAVGLGAVGYATQASLFFSALQRMDASLLALILYTYPVMVTVVAVALGRDRLSPARGAALVAASAGTLLVLLGAGGVSFHPVGALLAFASAVTYTVYILVADTVVHRLAPAVLSVLVLTGAAGTLGVRALLTGGVDLGFGPSGWFWLACIAVVSTVVAMLTFFAGLKRTGPSTAAILSTFEPVVTAALATLVLGESLTPVQLLGGVLVLSSVAVLQLRRTRRQGPAPERDRPVVTAGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1L8</accession>
    <name>F4F1L8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733901.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20735"/>
    <dbReference type="EnsemblBacteria" id="AEB45247">
        <property type="protein sequence ID" value="AEB45247"/>
        <property type="gene ID" value="VAB18032_20735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20735"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060500_2_0_11"/>
    <dbReference type="OMA" id="PGWNRRQ"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="27967" checksum="F0A8C746A5F40372" modified="2011-06-28" version="1">MRLATFNLLHGRSLTDGLVDPHRLAAAVTALDADVLALQEVDRDQSRSGNLDLTAIAAQALHADEHRFAAAVVGTPGEAFRPLTHDDDGHGEPCYGVGLISRHPVTTWQVTRLKPAPVRSPVYAPGAGGGGLILLRDEPRVVLAAVLDTPHGHLTVAATHLSFVPGWNVLQLRQVIRALRTLPAPRILLGDLNLPAWATRLTTGWHLLGRRPTYPAAAPRVQLDHAIADRRGFTQLPPVTAVRTPLSTISDHRPLLVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1T7</accession>
    <name>F4F1T7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27196"/>
    <dbReference type="EnsemblBacteria" id="AEB46512">
        <property type="protein sequence ID" value="AEB46512"/>
        <property type="gene ID" value="VAB18032_27196"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27196"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887494_0_0_11"/>
    <dbReference type="OMA" id="VPKALCP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="29502" checksum="912E6605DC8FBD01" modified="2011-06-28" version="1">MASLDGGLCAVVLAAGEGTRLRPLTERLPKALCPVGNVSLLDRALARLAGLGLTGPQQVAVNACYLGDQVVEQVGTRAHLSVEQGTPLGTAGGIGNLRDWIAGRGVLVGNADAYLADPTSPPGPDIAALLHDWDGESVRLLGQPAPDPTTPGTFDGHLFTGFSLLPWRLVRELPPTFGDLVRAVWRPAEAAGRLTVVPYPGTFYDTGTPADYLTANLHAAGDDSLVDPTATVTGHCHHSVIGAGATVRGTVTRCVLWPGATVHTDENLHDVIRVDENLTVPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1T8</accession>
    <name>F4F1T8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator asnc-type-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735163.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27201"/>
    <dbReference type="EnsemblBacteria" id="AEB46513">
        <property type="protein sequence ID" value="AEB46513"/>
        <property type="gene ID" value="VAB18032_27201"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27201"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_3_0_11"/>
    <dbReference type="OMA" id="ETHIAFR"/>
    <dbReference type="OrthoDB" id="1855714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="95" mass="10034" checksum="669F0ECAB7C69D79" modified="2011-06-28" version="1">MITAIVLIDCATDAIPEVAEALANLPGVSEVYSVAGHVDLIAMVRVREFDEIARVIAGSISKVPGVLNTESHIAFRAYSRHDLEEAFAIGLAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1V7</accession>
    <name>F4F1V7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ordered locus">VAB18032_27296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735182.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27296"/>
    <dbReference type="EnsemblBacteria" id="AEB46532">
        <property type="protein sequence ID" value="AEB46532"/>
        <property type="gene ID" value="VAB18032_27296"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27296"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_11"/>
    <dbReference type="OMA" id="CRFGQRN"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="451" mass="48554" checksum="D36660C3C9C69244" modified="2011-06-28" version="1">MTDDVLVVHGGTPLQGRIRVRGAKNLVSKAMVAALLGDSPSRLFDVPKIRDVEVVRGLLGLHGVKVSDGVEDGELVFDPANVESASTDQINVHAGSSRIPILFCGPLLHRLGHAFIPDLGGCHIGPRPIDFHLQALREFGATVEKTPEGLHLSAPNGLHGTKFALPYPSVGATEQVLLTAVMAEGVTELRNAAVEPEIIDLICVLQKMGAIIKVHTDRVIEIQGVPKLHGYTHRPIPDRIEAASWAAAALATRGHVEVLGAEQADMMTFLNVFRSIGGEYEVTDTRPPRPGQPGQEGGIRFWHPGGELQATALETDVHPGFMTDWQQPLVVALTQARGLSIVHETVYEQRLGYTEALNSMGANIQVYRDCLGGTPCRFGRRNFKHSAVIAGPSKLHAADLVIPDLRAGFSHLIAALAAEGTSRVYGVDLINRGYEDFEAKLADLGAHVERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1X8</accession>
    <name>F4F1X8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide/dipeptide ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_03205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736357.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03205"/>
    <dbReference type="EnsemblBacteria" id="AEB47725">
        <property type="protein sequence ID" value="AEB47725"/>
        <property type="gene ID" value="VAB18032_03205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03205"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="VACHWAE"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="10"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="367" mass="40172" checksum="B15EDA5171E09F38" modified="2011-06-28" version="1">MTDSDILVEVRDLKVHFPIKRGVLFDRTVGYVKAVDGVDLRIARGKTYGLVGESGCGKSTLGRALLQLNPPTAGQVSFDGVELTTLAPNKLRAMRKRMQMIFQDPMSSLDPRQNIESILTEGLQTHGIGGNREERRKIISETLDKVGLPRWALSRYPHEFSGGQRQRIGIARALVLGPELIVADEPVSALDVSIQAQVVNLLDELQDSLGLTYLVIAHDLAVVRHISDTVGVMYLGALVEEAPGDRLYTEPLHPYTRALMSAVPVPDPDVEDRRERILLAGDLPSPANPPAGCRFHTRCPWAQPTRCADERPVLREIGESRVACHFAERIASGELRPHKVSVEIVRPAGEGEEPGTVSAPTEPGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F282</accession>
    <name>F4F282_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08265"/>
    <dbReference type="EnsemblBacteria" id="AEB42771">
        <property type="protein sequence ID" value="AEB42771"/>
        <property type="gene ID" value="VAB18032_08265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08265"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_1_0_11"/>
    <dbReference type="OMA" id="GIVFDFA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="130"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="21369" checksum="3AD38AFD0B791B38" modified="2011-06-28" version="1">MRVELLARRRALTETERHAAAARVQDELAALVRRLRPARVAAYVPVGSEPGGAQLPAVLAAALPPGAQLLLPVLRDDLDLDWAAWAGPQALVAAGRGIREPATPRLGLTAIATADLVVVPALAVDRRGVRLGRGGGSYDRALARVPANVLTVTPLYDGELLDTLPAERHDRPVRAVVTPASGLLSLDTLSGVVTHTSAGRIGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F292</accession>
    <name>F4F292_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_08315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731452.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08315"/>
    <dbReference type="EnsemblBacteria" id="AEB42781">
        <property type="protein sequence ID" value="AEB42781"/>
        <property type="gene ID" value="VAB18032_08315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08315"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_1_11"/>
    <dbReference type="OMA" id="AAETDWV"/>
    <dbReference type="OrthoDB" id="1469807at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="381" mass="41341" checksum="3FEBC4B99B3AE303" modified="2011-06-28" version="1">MDEALLRSLIPGVLGALVRRGADFAAAEDAVQDALVEAIRTWPTEPPRDPQRWLITVAWRRFLDVARADAARRRREDLLDEEPAPGPAPSVDDTLALYFLCAHPSLTPSSAVALTLRAVGGLTTRQIAQAYLVPEATMAQRISRAKRTVSVVRFDQPGDVATVLRVLYLVFNEGYSGDVDLAAEAIRLTRQLAAVIDHPEVAGLLALMLLHHARRASRTAPDGSLVPLAEQDRGRWDTTAIAEGIAILQAALARDRLGEFQAQAAIAALHADARAAEETDWVQIVEWYDELAHLTDSPVVRLNRAVAVGEADGPRAGLAALAVLDESLPRHTAVAAYLHERDGNPVTAARLYAEAARKAPNLAERDHLTRQAARLNTSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2A1</accession>
    <name>F4F2A1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-arabinofuranosidase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_08360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08360"/>
    <dbReference type="EnsemblBacteria" id="AEB42790">
        <property type="protein sequence ID" value="AEB42790"/>
        <property type="gene ID" value="VAB18032_08360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08360"/>
    <dbReference type="eggNOG" id="COG3940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_2_1_11"/>
    <dbReference type="OMA" id="LFQHRMY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="SSF110221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312621" evidence="5">
        <location>
            <begin position="24"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="AbfB" evidence="6">
        <location>
            <begin position="340"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="470" mass="52136" checksum="1FD0B97EA2CA535E" modified="2011-06-28" version="1">MVAAVMVAGVGAVVGVVVGPARAAAVVFSNPLAEQRADPHIYRHTDGYYYFTATVPEYDRIVLRRASTLQGLATAPERVIWRKHGSGEMGAHIWAPEIHYIDGRWYVYFAAGRTDDIWAIRPYVLESSAANPLDGPWVERGQLQPARSSFSLDATTFVHNGQRYLAWAEYAGSNSNIYLARAVNPWTYAGTPTLIATPTYAWETRGYRVNEGPAVLIRNGRVFMTYSASATDASYAVGLLTASAGSDLLNPASWSKRATPVLASDARTGQWGPGHNSFTVAEDGSDVIVYHSRNYERYLGNGYDPLSDPNRRTRIQRVYWNTDGTPNFGVPVPDGATPVRLRAHDQPDRYLRHWEFRVRLEPNVTNLADSQFRIVTGLSNSGAISLESTNYPGYYLRHRNHQLWVERNDGSNLFRQDATFTRRAGLADVAKVSLESVNFPGQYVRHRDGLLYLEAVPDAAGRASATFALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2C1</accession>
    <name>F4F2C1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732660.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14405"/>
    <dbReference type="EnsemblBacteria" id="AEB43993">
        <property type="protein sequence ID" value="AEB43993"/>
        <property type="gene ID" value="VAB18032_14405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14405"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_11"/>
    <dbReference type="OMA" id="AICVGGE"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="36"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="503" mass="51409" checksum="58542A295D87ACFE" modified="2011-06-28" version="1">MSASNGNLAALATAVLQPGFVGTVPPDWVRRWLGDGLGSVVLFSRNVVDPEQVSALTAALRAERPDVIVAIDEEAGDVTRIESVRGSSRPGNLALGIVDDPALTEEVARDLGAELAAAGVTLNYAPDADVNSNPDNPVIGVRSFGADAALVARHTTAWVRGLQSSGVAACAKHFPGHGDTHVDSHHDLPRITADRARLDAVELAPFRAAVAAGVQAVMTGHLLVPALDPHLPATLSSRILGGLLREELGFSGVVVTDGIEMQAVAGRYGLAGAVVRALAAGADAICVGGEHADEQTVRHLRDAIVAAVVTGDLPEERLAEAAKRVGQLAAWTVAARAAGPVGDPADGTGSAVGLHAARRAVRITRTGGEAALPLGRAAHVVEFAPPHNIAIGADTPWGVAAPLAELLPGTTVARYTEAATPADPGADAAGRPLVLVVRDLHRHTWMRAAVDRALIARPDAVVVELGVPALVTGPVHIATHGATRAAGRAAAEVLSGVTVTSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2F4</accession>
    <name>F4F2F4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ordered locus">VAB18032_14570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732693.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14570"/>
    <dbReference type="EnsemblBacteria" id="AEB44026">
        <property type="protein sequence ID" value="AEB44026"/>
        <property type="gene ID" value="VAB18032_14570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14570"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_4_0_11"/>
    <dbReference type="OMA" id="SCYPQRA"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="131" mass="14626" checksum="DD7F291E5ECAB73F" modified="2011-06-28" version="1">MKYLIDTSALVRMVRREAEPHWSGLAARGLIGICDPVLVETLTIADAKAYDRVERGLRDLYPWVPVPDDAWQVVRAVRQELASHNAHQGLSVADHLVAATAIRLKLVVLHQNADFETAARLVPQLSQERIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2R2</accession>
    <name>F4F2R2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733981.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21135"/>
    <dbReference type="EnsemblBacteria" id="AEB45327">
        <property type="protein sequence ID" value="AEB45327"/>
        <property type="gene ID" value="VAB18032_21135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21135"/>
    <dbReference type="eggNOG" id="COG1944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020793_1_0_11"/>
    <dbReference type="OMA" id="FRDRERW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="2">
        <location>
            <begin position="266"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="652" mass="71694" checksum="2844665CCA6644BC" modified="2011-06-28" version="1">MIVDVRTTSTGWDSSLKQLGEVLHERRQDRPPAPGPTPLDGLTVRIAALGLIDANRDSAETVSGGDVLPVWLSSATALVGPRWSPPTQGEHVGPCPLCVQRRWQAIRVREERHALEHGARVGTVGALPHLTPFAVDALWQLLLTAADSPPDRPGVGRLWQLRMDTLETTTVAVLVDSECPTCARPVPDTAEAAVMPLTSRPKPDPESYRLRSAGELDLPVTALANPLVGALGGNALRAYNATATAPVTGYFRVRSRYDLHEMWWSGHANSYGSSETYALLEGLERYAGQFPRARTTTVFDSYTNLAPHALDPAGLGYHPAFYHGHGLYYAPYSPTEPMHWVWGYSLRDRAPRLVPEQLVYYLDRRTDQRKFVQECSNGCASGSCLEEALLHGMLELVERDAFLLAWYGSARLAEIDPATCRDERVHFMIDRVNLLGYDLRLFDTRADLPVPVVTAVAVKRGDGLGQLCFAAGASLDPDDAVRAAVCETASYVPGFDERVAASEAELREMTRDYTKVTELSHHALLYGLPEMTDHARFLFDNPPLRSMTDLYGDWLATRPTHDDLWADTEYLGGLIAGLGGDVVAVDQTCPEQEIAGVHTVAVVAPALVPIDFGWQRQRVLYSDRLERHLARGTHGPDRLGATGRNLNPHPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Z8</accession>
    <name>F4F2Z8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional deaminase-reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735259.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27681"/>
    <dbReference type="EnsemblBacteria" id="AEB46609">
        <property type="protein sequence ID" value="AEB46609"/>
        <property type="gene ID" value="VAB18032_27681"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27681"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_0_11"/>
    <dbReference type="OMA" id="IWLYGGA"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="188" mass="20313" checksum="BB30DCF1E61451C3" modified="2011-06-28" version="1">MRKLVYYVAATVDGFIAAPDGSYDFFDLHPDPAGHLVTKWPQTFPTFAHAQLGIDRPQGRFDTVLMGRATYEPALRVGVTSPYAHLKQYVFARSLPPSDDPAVEIVSGDPAAFVRDLKERPGGDLWLCGGGHLAGQLLSEVDEWVIKVNPVVAGSGIPLLDHSFAPQHLTLLAATPTGAGVVVLHYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F358</accession>
    <name>F4F358_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736469.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03775"/>
    <dbReference type="EnsemblBacteria" id="AEB47837">
        <property type="protein sequence ID" value="AEB47837"/>
        <property type="gene ID" value="VAB18032_03775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03775"/>
    <dbReference type="eggNOG" id="ENOG50337C4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144206_1_0_11"/>
    <dbReference type="OMA" id="TCVPCAY"/>
    <dbReference type="OrthoDB" id="1814076at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13675" checksum="FA34448C7A9EFC97" modified="2011-06-28" version="1">MSRIRAAYYDPDGTKYGIPTYWWRGAPPGYATRRQLRAAGLRPGGQPIAAQILWRGVGGTRTAYLYRVDLARPKRTATPAQLRAIDAALTARRTCRVCGVVRPYCIPRSLGECVDCAYPEGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3C8</accession>
    <name>F4F3C8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731523.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08670"/>
    <dbReference type="EnsemblBacteria" id="AEB42852">
        <property type="protein sequence ID" value="AEB42852"/>
        <property type="gene ID" value="VAB18032_08670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08670"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="OMA" id="QCFPAVD"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="197" mass="21528" checksum="27466AF3163541C0" modified="2011-06-28" version="1">MSHRPPAPSGRVTSAKIVIAGGFGVGKTTLVGSVSEITPLTTEAIMTSAGVGVDDTRQVPGKTTTTVAMDFGRISIDRDLILYLFGTPGQTRFWFMWDELVRGAIGAVVLVDTRRLADCFAAIDFFEHRRLPYLVAINCFDGMQYHDPQDVREALAISNDVPVVACDARNRESTKHVLISLVEYVLTMRRSRAVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Q0</accession>
    <name>F4F3Q0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734005.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21255"/>
    <dbReference type="EnsemblBacteria" id="AEB45351">
        <property type="protein sequence ID" value="AEB45351"/>
        <property type="gene ID" value="VAB18032_21255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21255"/>
    <dbReference type="eggNOG" id="ENOG5033I6R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168298_0_1_11"/>
    <dbReference type="OMA" id="QLCAIMP"/>
    <dbReference type="OrthoDB" id="1910692at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="103" mass="11327" checksum="0086A761693F914C" modified="2011-06-28" version="1">MPTGEHIQVDPDDLVTHAARLDRHADTLHTARQAGQHVRLSADAYGQLCAIMPTLLNGLQRILVDGLDTAATSVRDTAGRLRTSAENYRATDTRALDRVRNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3W8</accession>
    <name>F4F3W8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21595"/>
    <dbReference type="EnsemblBacteria" id="AEB45419">
        <property type="protein sequence ID" value="AEB45419"/>
        <property type="gene ID" value="VAB18032_21595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21595"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_11"/>
    <dbReference type="OMA" id="FWLHGGI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="18"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="36298" checksum="4F02B035EA1FF9FC" modified="2011-06-28" version="1">MEAHPADEESMRALMLTGDRHSEVRQVPRPVPAHDEVLVRVTVSAVCGSDLPHYRKSAQDLGHRLHTVPGHEAVGVIAQAAASGDGPAEGTRVIVYQHSGCGDCTFCLSGEPMFCADRRTLGNHRSGADGEYLTAPATGVLPVPADVSDAMAALIACNFGTAYSAFRKSGVAVGDRVAVFGLGPVGCCVVALAAAAGAEVFAVDPIEGRRDLAKTLGAGTVIDPIAQDPVAAVAAVTEGRGPEVIFECSANPAAQTQVMKLARPHGTVVLLGANNSMEIDPGVDVIRKELRVIGSWVFTQPEFPAVLRAARSLPALQHLITDPFPAHRAPEALAAADAGHIGKVLIDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Y7</accession>
    <name>F4F3Y7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27801"/>
    <dbReference type="EnsemblBacteria" id="AEB46633">
        <property type="protein sequence ID" value="AEB46633"/>
        <property type="gene ID" value="VAB18032_27801"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27801"/>
    <dbReference type="eggNOG" id="ENOG5033YVI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113328_0_0_11"/>
    <dbReference type="OMA" id="PAGNIGF"/>
    <dbReference type="OrthoDB" id="1808263at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044058">
        <property type="entry name" value="Lipoprotein_23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18966">
        <property type="entry name" value="Lipoprotein_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307654" evidence="1">
        <location>
            <begin position="29"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="219" mass="22809" checksum="AB7A6F6C0A74AF7C" modified="2011-06-28" version="1">MDIVRRSRLALAALAIGLLAGCGGGAQTDTGEQPGGAATGAPWHDEVTAATASETVGAGAPCPLPVTFGLADGWRVSEIKTADPNDEVAAAVAEALTRRGGTTARCEVDGRAVASGFLRVWTADDADAPARQTLEAFVAAEQKATDPQYRQTRVGDLDVIEASWLSHRELLDEDIREWALVVRAGGATVLLEASSTSFGDPLDLLPAYRLARDTLTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F441</accession>
    <name>F4F441_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735337.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28071"/>
    <dbReference type="EnsemblBacteria" id="AEB46687">
        <property type="protein sequence ID" value="AEB46687"/>
        <property type="gene ID" value="VAB18032_28071"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28071"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047974_0_0_11"/>
    <dbReference type="OMA" id="ENGYYDR"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="462" mass="50137" checksum="B4AC7EC67143F8B4" modified="2011-06-28" version="1">MTRKLLVLDVVGLTPRLLAHMPRLRAVADTGFSAELGTVLPAVTCSVQSTFLTGALPAEHGIVGNGWYFRDLGEVLLWRQHNALVGGEKLWQAARRVRSDYTVANVCWWYAMGADVDWTVTPRPVYYADGRKEPDCYTDPPQLHDDLTARLGTFPLFTYWGPGAGLPSSSWICRAAEQILTEQSPDLTLVYVPHLDYDLQRFGPSAPQAAAAAAELDGVLAPLLDAAQARDTTVVVLSEYGITDVSRPVDVNRLLRAEGLLRVHTQAGMEYLDPWTSRAFAVADHQIAHVYVRDPADVPAVAKLCAGLPGVAEVLDADGKAAHGLDHPRAGELVLVAEPDAWFTYYYWLDDARAPDFARLVEIHRKPGYDPAELFFDPAAPGAAKRRAAVALARKKLGMRYLMSVVGLDAGARAVRGSHGRLPTDPADGPVLLCSDPSPARDRIAATEVKGLLLELAGLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F453</accession>
    <name>F4F453_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736498.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03920"/>
    <dbReference type="EnsemblBacteria" id="AEB47866">
        <property type="protein sequence ID" value="AEB47866"/>
        <property type="gene ID" value="VAB18032_03920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03920"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1685825_0_0_11"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="16959" checksum="6E0224938A39CDDC" modified="2011-06-28" version="1">MRGADRLIEQQYAMLLRRDVARLPELYAVDGSYGMPGVTVRPTELPALLRTWTGAFPDLRVDPLGAVRTAGGAAVEHRLTGTHTGVLHTPFGTVAPTGHSVSWQVVDMVRVRRGRIVTWRSYFDWGQLITSLGVQVAGLSRQVPLASVSPVSSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4F7</accession>
    <name>F4F4F7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731586.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08985"/>
    <dbReference type="EnsemblBacteria" id="AEB42915">
        <property type="protein sequence ID" value="AEB42915"/>
        <property type="gene ID" value="VAB18032_08985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08985"/>
    <dbReference type="eggNOG" id="ENOG5030HFF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2082087_0_0_11"/>
    <dbReference type="OMA" id="RNSGFVE"/>
    <dbReference type="OrthoDB" id="1924336at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312680" evidence="2">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="12402" checksum="7E9565079BE1141B" modified="2011-06-28" version="1">MTLKWSAVVVATVSVTLCVTGNAVTLALDGGQLPLLVNLVALVAASTAIVLAVIAELHERLNDRVTALTEFLVERLREIEAHTGDRNAGFVEGYLLSHGQEAAVLPFGRRGRGAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4F8</accession>
    <name>F4F4F8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731587.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08990"/>
    <dbReference type="EnsemblBacteria" id="AEB42916">
        <property type="protein sequence ID" value="AEB42916"/>
        <property type="gene ID" value="VAB18032_08990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08990"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123344_0_0_11"/>
    <dbReference type="OMA" id="KFHIRET"/>
    <dbReference type="OrthoDB" id="1660564at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="147" mass="16438" checksum="4390386578BA2040" modified="2011-06-28" version="1">MTETANARKIAFATFVRRALDEARATRAWSGTEVSRRTGVSRQTINRWVRGDWASDPEAERVVAFCEGLGLDPTPAFAALGWDRTSARHRSTSTPPPMDPDVEALLRRLVDPDVSDAEKFHIRETIRYLAYRPTLPTGVRKRGEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4I0</accession>
    <name>F4F4I0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lmbe family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_09100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09100"/>
    <dbReference type="EnsemblBacteria" id="AEB42938">
        <property type="protein sequence ID" value="AEB42938"/>
        <property type="gene ID" value="VAB18032_09100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09100"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015187_0_0_11"/>
    <dbReference type="OMA" id="AGIEHIY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="NPCBM_assoc" evidence="4">
        <location>
            <begin position="351"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="3">
        <location>
            <begin position="576"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="902" mass="96036" checksum="F2D3DA023071AFC1" modified="2011-06-28" version="1">MCGLLSLGLAAPVQAHGKGSSPKHPSPPKAQPKGPDKKSDKPIDLDIMFIGAHPDDEAGQLGMLGYWNEYHGMKAGVITTTRGEGGGNATGFEEGPELGILREAEERRAVGYAGIEHIYNLDALDFWYTASAPLTAEVWGYDETLSRIVRVLRTTKPEVILTMNPSATQGNHGNHQEAAMLAVDAFYAAADPKKFPEQITKEGLEPWRVSRIFQTGGSGSGNMGPSCETSFTPAEASNVIFGTWQGYESARHDGNRWNTVTTWARREYVSQGWGNSAFPTTNPDNIGCNRLTLIDTRTPYPDPNVGAGTGALQGATLRAPGGLPLGTEIHVRPQKWEVLAGKSIKVDTVLYATQDIKGANVSLQVPAGWRVSGNGNVGTLKKGKAVVKSFTVTPPAQLPVGTRFKIEATMTSSKDGSGTSSARVQATAPVRGTLEPLEEIADFRAWTEQKKVKQLDALIESLLNIPSGKSRSVRVDLTNHSDTVQSGTVRLNLPAGFSANPQQLPYSGLQPGARSSVTFTVTNTDATLPTANRAPDNGAYRLEIETSYNGGSATEPGAFNLVPTTVIPKATTAPAVDGHGHSHEYTGEVIDISTRWEGTATTAADISGTAQLTHTDDALYAIFNITDDVLGRFLLPEDCKRPRRADAVEFGIDPRGNSANTSTVFNVALFPATDDPANGNPPCFARERDNHQGGPETAPGLEVASVLTGTGYQIEVKVPFSVLPDTIDPTNMGMNILVNDSDTQDLSTQTRIGWSTWSGVRADPWRWGVATLPGLPARPAAPKAPIMPDTAAQSVKSPQTILQSASDGVAPGGYAALDEKILKIKKVTKSSSKVSVELKVKKSGVARVFIWDGERVVAQTEVSLNKDRTLVLPLNGALPAGSSLLVSYERDGATLGLAHTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4L5</accession>
    <name>F4F4L5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">argJ</name>
        <name evidence="8" type="ordered locus">VAB18032_15225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732822.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15225"/>
    <dbReference type="EnsemblBacteria" id="AEB44157">
        <property type="protein sequence ID" value="AEB44157"/>
        <property type="gene ID" value="VAB18032_15225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15225"/>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_2_0_11"/>
    <dbReference type="OMA" id="DYVHENS"/>
    <dbReference type="OrthoDB" id="1083409at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023435064" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023435065" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="186"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="390" mass="39134" checksum="2D12A73051207243" modified="2011-06-28" version="1">MTVTTPAGFRAAGVAAGLKSSGAPDIAVVVNDGPDTGVAGVFTSNRVKAAPVAWSEQVLHGGVVRAVVLNSGGANACTGPAGFQDTHATAEHAAAALTAQHPDQPFGAGEVAICSTGLIGERLPMDKLLPGVSAAIGGLTVDGGDAAAEAIMTTDTRPKTTVISGAGWTVGGMAKGAGMLAPAMATMLCVLTTDAVADPQTLDAALRAATRVTFDRIDSDGCMSTNDTVLLLASGAAGVTPSAAELTAAVTAACHDLAQQLIADAEGATKQIAIEVVGAADEDDAVEVGRSVARNNLVKTALFGNDPNWGRILAAVGTTAAEFEPDAVDVAVNGIWVCRGGAAAEDRSKVDLTGRDVTIRIDLHAGVTEATVWTNDLSHAYVHENSAYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4M4</accession>
    <name>F4F4M4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732831.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15270"/>
    <dbReference type="EnsemblBacteria" id="AEB44166">
        <property type="protein sequence ID" value="AEB44166"/>
        <property type="gene ID" value="VAB18032_15270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15270"/>
    <dbReference type="eggNOG" id="COG3152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093674_4_1_11"/>
    <dbReference type="OMA" id="WMFTLFN"/>
    <dbReference type="OrthoDB" id="1961299at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008523">
        <property type="entry name" value="DUF805"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34980">
        <property type="entry name" value="PTHR34980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05656">
        <property type="entry name" value="DUF805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="122" mass="13324" checksum="2C52B4F07AA0490E" modified="2011-06-28" version="1">MSFPDAIRSAFSQYATFRGRARRSEYWWFSLFLLLVGIVASVLDGALGVDFEGSGGPVSLLVNLAVLLPSLAVAVRRLHDIDRTGWWLLLALIPIVGWIVLLVFALQNGTPGPNRFGPSPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Q9</accession>
    <name>F4F4Q9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome segregation and condensation protein scpa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732866.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15445"/>
    <dbReference type="EnsemblBacteria" id="AEB44201">
        <property type="protein sequence ID" value="AEB44201"/>
        <property type="gene ID" value="VAB18032_15445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15445"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_1_0_11"/>
    <dbReference type="OMA" id="YLVMAAM"/>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="356" mass="37835" checksum="E293DF00B239A197" modified="2011-06-28" version="1">MTAPPLDPAAADDQTPVADPDAVDGADTGKFTVRLANFTGPFDLLLQLIGKHKLDVTEVALHQVTDEFIAYIRAMGDDWDLDEASEFLLIAATLLDLKAARLLPSAEVENEEDLALLEARDLLFARLLQYKAYKEAAAHIAALEEVGGRRYPRAVTLEPRFAEALPDLVLGIGPQRLLKLAVKAMTPKPIPEVSIAHVHMVRVSVREHAGIIAERLRRAGTATFSLLCADCEATLEVVARFLALLELYRQGVVAFVQEQALEELTVRWTGPADGGPALTIDEYAGAPAEPAENPTAPAAETDPEPGSVVDTDPGPAPVVHTDPGPVVVVDTVTDSGAVSGSEAGTDGTATRQEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4U0</accession>
    <name>F4F4U0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase, FGGY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21645"/>
    <dbReference type="EnsemblBacteria" id="AEB45429">
        <property type="protein sequence ID" value="AEB45429"/>
        <property type="gene ID" value="VAB18032_21645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21645"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102480_0_0_11"/>
    <dbReference type="OMA" id="TDIFGHE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="23015" checksum="A9F96448ED9448CD" modified="2011-06-28" version="1">MAGGTATSGAVVEWLRELVGGTSYEQLAAEAAVVPAGADALVVLPYFAGERTPLFDEKARGLVAGLTLDHGRGHLYRAVLEGTAYAIRHHLDEMSGALTPPQRVIAVGGGARPLWTRIVSDVTGQTQLIPEQTIGASYGDAYLAGLAVGLVDRADDWTRWAARVEPDPSTAAAYHRGYTAYRSLYPATRTIIHDMVNGWRSSSGHTTSTTAPTANGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4U6</accession>
    <name>F4F4U6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsD</name>
        <name evidence="10" type="ordered locus">VAB18032_21675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734088.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21675"/>
    <dbReference type="EnsemblBacteria" id="AEB45435">
        <property type="protein sequence ID" value="AEB45435"/>
        <property type="gene ID" value="VAB18032_21675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21675"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_3_11"/>
    <dbReference type="OMA" id="PVICDEQ"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="91"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="202" mass="23181" checksum="1801BDAD1F73B6D7" modified="2011-06-28" version="1">MNHPRPKARLSRALGIPLTRKCVRYVERRPYPPGVHGRSRRKTSDYQVRLLEKQRLRHQYNVSEAQLRRTFDEAARRTGKTGESLVTLLEQRLDAVVLRAGMARSIYQARQLVGHGHFTVDGRKVDRPSYRLRPGQVVAVRQRSQALPPFQLAAAGAHAEEQPRPYLSVDLSGLRATLLREPARREVPVVCDEQLVVEYYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5A1</accession>
    <name>F4F5A1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_04335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04335"/>
    <dbReference type="EnsemblBacteria" id="AEB47949">
        <property type="protein sequence ID" value="AEB47949"/>
        <property type="gene ID" value="VAB18032_04335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04335"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_6_1_11"/>
    <dbReference type="OMA" id="WFGRGSY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="50"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="339"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB47949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="752" mass="81067" checksum="CB563F9C729EEEDD" modified="2011-06-28" version="1">MNLLIASFAVFIMLAGIGVVGFTYYSTNVVLPKEIPLPLSTTVYAKDGKTLVAKLGNENRTFVTIENIPQHVRDAVAAAEDRNFYRHSGVDYKGIARAAWNNLSGGDKQGASTITQQYARNAYENLQDVSYSRKVKEAILASKLNDQFTKDEIMENYLNVIYFGRGAYGIEAAAQTFFGVSAKKLNVAQGAVLAAMIKQPDASATHQGYDPETNPTEAKIRWEYVINGMVEEGWLGAPGKPERPTEYPKVQKIKKDNGFGVASPRGNVINYVRKEMADWGICTESGEPGKPSCVNELREGGYRITTTLDPKMQKALEEIAQVGRKGVFLADQPKNLMPAVVSVEAKTGRVLAYYGGNSGADFDYAGLNTDQNGNLVGGHPPGSTFKVYTLAAAIDAGISVKSYWDATPFKPEGFKDPIVNAGRDVRQSCNKSCTLQESTVLSYNVPFFHIAEQIGTDKVIDMARRAGVRTMWNDKQKAFDLLKNKPEDLAPGQFDRVAAYGQYPITVLDHANGMATFANGGKYNKAHFVRTVEKLNKATGKWDKVPGTGEKLKPQQVIRPEVADEVTAVLKEIPGKNNASVPNRQVAAKTGTWQLGDTGKNQDAWMVGYDKNIATAVWIGSRDVKKRAIIDRGGSNIGGGGLPGQLWKRYMEQALKGYDPSDLPNVSGIGDAEAGNGVPPAPPPPEQPECEPTDFLCRLGGGRNDGGDNRGGGRDNNGGGTIPTNPLPPGRDSPPGGGGGGGLLPPRSTDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5S4</accession>
    <name>F4F5S4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732951.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15885"/>
    <dbReference type="EnsemblBacteria" id="AEB44287">
        <property type="protein sequence ID" value="AEB44287"/>
        <property type="gene ID" value="VAB18032_15885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15885"/>
    <dbReference type="eggNOG" id="ENOG5031VRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198674_0_0_11"/>
    <dbReference type="OMA" id="LNDACAY"/>
    <dbReference type="OrthoDB" id="2115031at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="25609" checksum="EA63AD92189F58BB" modified="2011-06-28" version="1">MPTPAAIVGLTVTVCFSPGADADWFAACEKVHDLLDAHGTPARRYHVRHRPVIGWLTRFFGYYLLDAVRRFGAVTRAAGGRKSRLDLTRTAATAARHATLRWRAWNTLIATTTRPARPWEDFLAHHHADPATIPPNEARRRFEQQPQVLAMIAHHLDPYELSAYQAGEHTYVGLHWRIALIGDALITTDGRLLAPASDSVADRFRFLNEACTYVRGLRPDARLCAITLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5X8</accession>
    <name>F4F5X8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GHMP kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22185"/>
    <dbReference type="EnsemblBacteria" id="AEB45537">
        <property type="protein sequence ID" value="AEB45537"/>
        <property type="gene ID" value="VAB18032_22185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22185"/>
    <dbReference type="eggNOG" id="COG4542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056896_2_0_11"/>
    <dbReference type="OMA" id="DWYSTVE"/>
    <dbReference type="OrthoDB" id="1240505at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012363">
        <property type="entry name" value="PduX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF1">
        <property type="entry name" value="PTHR43527:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033887">
        <property type="entry name" value="PduX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="2">
        <location>
            <begin position="205"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="298" mass="31388" checksum="5E7B73C47E2369B7" modified="2011-06-28" version="1">MSTGQAHRSRTATGVSSAFGTFGELLQGVLPDQVDFLVTMPIARWATATFELAASGGVSVTPAHKTKARRLAESILAVHAPGAGGRLTLDGTIPEGKGLASSSADLVATARAVANALGVHLPDTDIEDFLREIEPTDGVMYPEVVAFDHRAVRLRARLGVLPPLTVVGIDEGGTVDTVAFNRIPKPFPAATRAEYARLLDTITTAIAVGDLATVGRVATRSAELNQQLRPKRSLTAMLAICAEAGGVGVVVAHSGTAIGVLLPHQALGYERRLDLTLRRCAELSDQVLLYHALCVDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F632</accession>
    <name>F4F632_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_28566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735433.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28566"/>
    <dbReference type="EnsemblBacteria" id="AEB46784">
        <property type="protein sequence ID" value="AEB46784"/>
        <property type="gene ID" value="VAB18032_28566"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28566"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616504_0_0_11"/>
    <dbReference type="OMA" id="SEPPTQY"/>
    <dbReference type="OrthoDB" id="1058859at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="355"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="476" mass="50367" checksum="F6DFC2AD1051E328" modified="2011-06-28" version="1">MANGGNRPIAPVRKLVAAVLGTVASFVILFGLGMTSWAIVALGVAVLALAIALATVRAGGRTWVVGAGHVHSASEPPTQYAFGRCELQLVIDAPGLPPRSKKIIEPRVPVSKWPSLGQSLPIRVALDDPRHVRVLWDEVPTHAETDPTEPPPEYATQVPPDEVLIGQEAPPWADRAPEDDFPLSDPLAGPTGDEPVEPVEPREPVRVRQRPGGPVVLEGTVVEQSNDHQLPRRATPAPRTPAEERFAAATASTEALVDAQPSGARLAEAATRSPDPLDPLDLPLDDPQPRPTAAGDLASGPSTASDPAPSAVDSEASVDSEAAVDDAVEARKLDEAIFGYDPEAVDTADPAAPISGVGITLLVTDLARSLAFYQGRLGFTEVDRGTGNAVLASGATRLVLREVSGAQPVSRRLVHVNLDVDDIQGAYEQLRDSGVRFTYAPRVVNRGNRLEVWAAAFRDPDGHGIALTQWRERADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F641</accession>
    <name>F4F641_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ordered locus">VAB18032_28611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735442.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28611"/>
    <dbReference type="MEROPS" id="S14.008"/>
    <dbReference type="EnsemblBacteria" id="AEB46793">
        <property type="protein sequence ID" value="AEB46793"/>
        <property type="gene ID" value="VAB18032_28611"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28611"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_11"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="23099" checksum="2C4468608F38AF65" modified="2011-06-28" version="1">MTDMHIPAKPRALDARGGDSIGNLDDSVYNRLLKERIIFLGSEVNDQVANRICAQLLLLAAEDPDRDIFLWINSPGGSVYSGMAIYDTMQYIDNDVSTVAMGMAASMGQLLLCAGTKGKRYALPHARIMMHQPSGGLGGTASDIAIQAEQMLYTKRMFQERVAHHTGQSQAQIEADSDRDRWFTAQEAMDYGFIDKVIIGAAQVPEGAGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F685</accession>
    <name>F4F685_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ordered locus">VAB18032_28831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735486.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28831"/>
    <dbReference type="EnsemblBacteria" id="AEB46837">
        <property type="protein sequence ID" value="AEB46837"/>
        <property type="gene ID" value="VAB18032_28831"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28831"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="322"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="558" mass="61892" checksum="A25A64B7987EE3F6" modified="2011-06-28" version="1">MAQFIYVLEKARKAHGDKVVLDNVTLNFLPGAKIGVVGPNGAGKSSLLKIMAGLDRPSNGEARLMPGYTVGLLAQEPPLNEEKTVLGNVEEAVAETKAKLERFNAIAEQMATDYSDELMEEMGRLQEELDNADAWDIDSKLELAMDALRCPPPDADVTTLSGGERRRVALCKLLLEAPDLLLLDEPTNHLDAESVQWLEQHLAKYAGTVLAITHDRYFLDNVAGWILELDRGRAIGYEGNYSTYLEKKAARLSVEGRRDAKMKKRLSEELEWVRSNAKARQTKSKARLDRYDEMAAEAEKTRKLDFEEIQIPPGPRLGNTVIEAHNLTKAFGDRVLIENLSFSLPRNGIVGIIGPNGVGKTTLFKTIVGLEQPTSGSVKVGETVSLSYVDQNRQGLDGDKTVWEVVSDGLDHLMVGKVEMPSRAYIAAFGFKGPDQQKPTKVLSGGERNRLNLALTLKIGGNVILLDEPTNDLDVETLSSLENALLEFPGCAVVISHDRMFLDRVATHILAWEGDDENPAKWFWFEGNFEAYEKNKIDRLGAEAARPHRVTYRKLTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6B8</accession>
    <name>F4F6B8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_09730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09730"/>
    <dbReference type="EnsemblBacteria" id="AEB43064">
        <property type="protein sequence ID" value="AEB43064"/>
        <property type="gene ID" value="VAB18032_09730"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09730"/>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_18_11"/>
    <dbReference type="OMA" id="GEPCMAE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="312"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="585" mass="62869" checksum="DC7FC0826E91813F" modified="2011-06-28" version="1">MTAAPIPDPDTTSRRPGAGRELWRRLSGRAARVFAGLHHTWRRSLQVRVVTITLVVSSLLVGGFAYLIAGKITSILLDNAKTDVRLRLTSGAEYAAKQFSLYSQPQEAQLQETIDGTVNYLAGGDPQQTSGVVVALTADGVGGMILPRSSPAVDFRPLISPELRAAVAGGNVANQIQTGRLTGDRDTKYLVYGSPVPTRFGQVELYYFVPLTLQDSTASQARTTVLLTGLALVLLLGLLAALVTRLVVTPVRVAARTAQRLSAGLLDQRMAVNGEDDLALLAASFNQMATNLQRQILRLEEMSRLQRRFTSDVSHELRTPLTTVRMAADLIFAERDGFEPSVARSAELLQAELDRFEELLTDLLEISRFDAGFAVLDAEPADLVPVVHRVVDRLSGLAERVGVEIELDVPATPVIAEIDPRRVERVLRNLVGNAVEHGEGRPVRITLGMDDTAVAVTVRDHGVGLKPGEEKLVFNRFWRADPSRARQTGGTGLGLSISLEDARLHGGWLEAWGAPGQGAQFRLTLPARAGDRLITSPLRLVPADAAVSFGATSTESQLAIGPGPDGALTVGPAKSVPEQRAEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6F0</accession>
    <name>F4F6F0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09890"/>
    <dbReference type="EnsemblBacteria" id="AEB43096">
        <property type="protein sequence ID" value="AEB43096"/>
        <property type="gene ID" value="VAB18032_09890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09890"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_6_2_11"/>
    <dbReference type="OMA" id="QAEWAQK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="420" mass="45998" checksum="123DF90121443903" modified="2011-06-28" version="1">MADVIRAVTAGPLPVRVTGYDGSAIGPADSGITLAIRTERGLSYLLTAPGDLGMARAYVSGDLALEGVHPGDPYEALRVFKDELRVRPPALAEGLALVRGLGWERLLPPPAPPQEALPRWKRVVGGLRHSRTRDSSAISHHYDVSNAFYEKVLGPSMTYTCAVYRSPDDTLEEAQASKYDLVAGKLALRPGMRLLDVGCGWGGMVRHAAREYGVKALGVTLSRAQAQWAQAAIEREGLTGLAEVRHLDYRDAPHEQFDAVSSIGLTEHIGVRNYPAYFGFLADRLRPEGRLLNHCITRADNRAPHRSGAFIDRYVFPDGELAGPGRVISEIHDVGLEVHHEENLRQHYALTLAAWCRNLVEHWDFCVGEVGAGTARVWGLYMAGSRLAFERNGIQLHQVVATRNGPDGVNGYPLRPDWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6H5</accession>
    <name>F4F6H5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731792.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10015"/>
    <dbReference type="EnsemblBacteria" id="AEB43121">
        <property type="protein sequence ID" value="AEB43121"/>
        <property type="gene ID" value="VAB18032_10015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10015"/>
    <dbReference type="eggNOG" id="ENOG50323DZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190809_0_0_11"/>
    <dbReference type="OMA" id="PYPCRLA"/>
    <dbReference type="OrthoDB" id="2181269at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="87" mass="9658" checksum="14F17A9EEDF090C4" modified="2011-06-28" version="1">MSAVLADFPVLIPVTDEDLALAALAVRVHAPEPWPEGLLCRSERVPYPCRLARWGHTTLEAAGLTAEQLNGEQREAEDQRETEDHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6M0</accession>
    <name>F4F6M0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated Cas5 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733008.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16210"/>
    <dbReference type="EnsemblBacteria" id="AEB44348">
        <property type="protein sequence ID" value="AEB44348"/>
        <property type="gene ID" value="VAB18032_16210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16210"/>
    <dbReference type="eggNOG" id="ENOG502ZBPB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084726_1_0_11"/>
    <dbReference type="OMA" id="FGVRIDQ"/>
    <dbReference type="OrthoDB" id="1706297at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010147">
        <property type="entry name" value="CRISPR-assoc_prot_CasD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01868">
        <property type="entry name" value="casD_Cas5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="233" mass="25679" checksum="3AAFF826A7128B1A" modified="2011-06-28" version="1">MSVLLLKLAGPLQSWGSSSRFARRGTEIAPTKSGVIGLLAAAKGMRRTEPLTDLLGLQFGVRLDQPGQILRDFQTARSLDGRRSAPLTYRFYLSDAVFLAAVSGDRTLLTGLAEALDRPQFPLYLGRRSCPPAGPINLGVHDDTLDDALNQWPWLAADWHRKKAARTVRLEIIRDARQGEPITETVPDEPVSFDPAHRQHTWRSVVRRHADVPNDLAERAGVAEHDPLSLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6M7</accession>
    <name>F4F6M7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase, IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16245"/>
    <dbReference type="EnsemblBacteria" id="AEB44355">
        <property type="protein sequence ID" value="AEB44355"/>
        <property type="gene ID" value="VAB18032_16245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16245"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_0_0_11"/>
    <dbReference type="OMA" id="AERTFAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="112"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="275" mass="30364" checksum="9B1DCFFD04C89E72" modified="2011-06-28" version="1">MSERRAYPSDLSDARWTLIAPRLTAWRQARTDAGVGGRTATHDLREILNAILYVNRTGIAWRHLPHDLPPYQTVYAYFAAWSKEGIFSELNYHLTGLVRDYHGRTTTPTASIMDIQSVKTSTNVPTTTQGIDPNKKIVGRKRGIITDTLGLLRTVIVTAASVSDYTIGMHLLDQATTAHPTLAKTWVDAGFKNRVVEHGARLGVDVDVVTKNPPVAQRHAHARLSRSHEAASRSMRSGSVADPSRSAPYAAISSSVRASATRDLPRRRDDCPLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Q4</accession>
    <name>F4F6Q4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733042.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16380"/>
    <dbReference type="EnsemblBacteria" id="AEB44382">
        <property type="protein sequence ID" value="AEB44382"/>
        <property type="gene ID" value="VAB18032_16380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16380"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_0_11"/>
    <dbReference type="OMA" id="ESCPARA"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="80" mass="8172" checksum="A22545A9337ACB7F" modified="2011-06-28" version="1">MSNAFRSPGDPVHVNIDAARCVGAGQCVRTDPTVFGQSDEGTVRLLRGSLPGSLRSVVTEAAALCPAQAITVTGTADPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Y9</accession>
    <name>F4F6Y9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="12" type="ordered locus">VAB18032_28911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28911"/>
    <dbReference type="EnsemblBacteria" id="AEB46853">
        <property type="protein sequence ID" value="AEB46853"/>
        <property type="gene ID" value="VAB18032_28911"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28911"/>
    <dbReference type="eggNOG" id="COG1270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054212_1_2_11"/>
    <dbReference type="OMA" id="WGYRNER"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB46853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="42897" checksum="B35A7C3260493438" modified="2011-06-28" version="1">MGGSRSRCDRLPGDGGRLVLASPAGRPAGPSWIEPVDVPGSARLPAGGGVVQHAGAVANAAGLVAGYALDALFGDPRRGHPVAGFGRAAAALERRLYRPDRLAGAAFTALAVSAPVLVGAAAAFATRRRPVARATLVAAGTWAVLGGRSLRHEAKAMGRELRSGDVPAARHRLGNLCGRDPSTLDEPELARATVESVAENTSDAVVAPLVWGAVAGLPGLLGYRAANTLDAMVGHRNARYDRFGTPAARLDDLLNLVPARLTGLLTVALAPVGHGDREQAWRVWRRDRADHPSPNAGQCEAAMAGALGVRLGGRNVYFGRSEARPFLGDGPRPEARHLSRAARISGAVGLAALGLAAVYPLTVGRLTTAVTRRTIGTGALIAIRSTSARSIAARLTRDRSGAAGAGVVGSGAVASGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Z0</accession>
    <name>F4F6Z0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-strand binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_28916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735503.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28916"/>
    <dbReference type="EnsemblBacteria" id="AEB46854">
        <property type="protein sequence ID" value="AEB46854"/>
        <property type="gene ID" value="VAB18032_28916"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28916"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_1_2_11"/>
    <dbReference type="OMA" id="RTHYELE"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="29438" checksum="D8471C18A1294078" modified="2011-06-28" version="1">MFDTYVTIVGNVLTAPEWRRTTQSNTLVANFKVASTARRLDRDSGRWVDGNSLRVRVNCWRKLAEGVAASVMVGDPVVVCGRLYTRDWTDEAGNHRTLYELEAVAVGHDLSRGRGRFLRNRPSLSTSAVSDAEAEQRVHGEPTEPVPDSEAPARPDLGGLDDEFELSDLGSDEYAASPGTRPGSGAYRPVGGDEPFPSDPFDGAEPAETSDELAPLAAEAVGSNAGGSDVGGSDAGGSAAGRFEGGEAAVESLGRPEESGAGAEVTGRGRRGRGRQPQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F775</accession>
    <name>F4F775_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731804.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10075"/>
    <dbReference type="EnsemblBacteria" id="AEB43133">
        <property type="protein sequence ID" value="AEB43133"/>
        <property type="gene ID" value="VAB18032_10075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10075"/>
    <dbReference type="eggNOG" id="ENOG50347IT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597090_0_0_11"/>
    <dbReference type="OMA" id="NDHEHAD"/>
    <dbReference type="OrthoDB" id="2157247at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="458" mass="50691" checksum="8250A739BE30B44D" modified="2011-06-28" version="1">MHDETTLHVSGSNGRRYSPVPCTTRLDLGPTRLTADTPVATPEPYPAGALSHGEAARLLGAKNEAEAALRAAHEGLLQASADLIGAWHQTRAALHRLALFAASRELYEATQELRRNDHEHADDRPEDRRERPIWQHPGVVWTVILISAVYDTVFFSDALRSAIDAPVGVLNFEYWASLVPGVGIAVALILAGSWLAVPLFRHRAWVDRRQLRGRLSLQTVLRRLVVWRAEEEHRTPADPPWPAWALPLTFAGLVVGVLGTWAWIRGDQSEFGKGWPMVALLVLLTISAIAFKANAYHPEADRAARIKRRLLATSQRGETLSSEARDHLDAYEKSWHKLSQTKEDASGAMRRPITRVWEEVAEERARHGLTGMVAPSFQHAAEGDVVGDQIFEGLAGPPLRDTALRRVGELLDTHHHETLADELAALERQLEAQKTVSWPPMRAISAGSAENSGGERMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7P9</accession>
    <name>F4F7P9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ordered locus">VAB18032_22930</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734338.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22930"/>
    <dbReference type="EnsemblBacteria" id="AEB45686">
        <property type="protein sequence ID" value="AEB45686"/>
        <property type="gene ID" value="VAB18032_22930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22930"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_4_0_11"/>
    <dbReference type="OMA" id="ADCIAMS"/>
    <dbReference type="OrthoDB" id="118138at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:pteridine-containing compound metabolic process"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cbl-bd_cap"/>
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        <property type="entry name" value="Cobalamin-bd"/>
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        <property type="entry name" value="Cobalamin-bd_sf"/>
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    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
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        <property type="entry name" value="HCY_dom"/>
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        <property type="entry name" value="HCY_dom_sf"/>
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        <property type="entry name" value="Met_synthase_B12-bd"/>
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        <property type="entry name" value="MetH"/>
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        <property type="entry name" value="Meth_synthase_dom"/>
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        <property type="entry name" value="Pterin-binding_dom"/>
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        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
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        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
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    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM01018">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 20 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="25">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="26">
        <location>
            <begin position="331"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="29">
        <location>
            <begin position="623"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="28">
        <location>
            <begin position="717"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="27">
        <location>
            <begin position="875"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="22">
        <location>
            <begin position="727"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="22">
        <location>
            <begin position="1163"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="775"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="922"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="AEB45686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1167" mass="126820" checksum="F2FE97DB3740581F" modified="2011-06-28" version="1">MLDALADRILITDGAMGTMLQAADLSLDDFDGLEGCNEILNVTRPDVVRGVHEAYLAAGADCIETNTFGANLPNLAEYDIADRIWELSEAGARLAREAADAYETPERPRWVLGSIGPGTKLPTLGHASYASLRDAYQQNAGGLIAGGADALIIETCQDLLQVKAAVIGSKRAMAEAGRQVPIICHVAVETTGTMLLGSEIGAALTAIEPLGVDLIGLNCSTGPAEMGEHLRYLSQHSTVPVSVMPNAGLPVLTSDGAYFPLGPEDMAEALERFVVDYGVALVGGCCGTTPEHIRVLAERLRDVAPVAREPRIDAGVSSIYHHVPFAQDASVLMVGERTNANGSKAFREAMLAADWQACVEIARSQARDGSHLLDLCVDYVGRDGTVDMRELAGRFATASTLPIMLDSTEPAVIEAGLEMLGGRCVVNSVNFEDGDGPDSRYARVMPVVAEHGAAVVALLIDEEGQARTAEWKVRVAERLINDLTERWGLRRADILIDALTFPIATGQEETRRDGIETIEAIREIARRWPGVNFTLGISNVSFGLNPAARQVLNSVFLHECVQAGLTSAIVHASKILPMAKIPEQQREIALDLIYDRRREGYDPVQRFIEVFEGVDAASARATRAEELAALPLNERLKRRIIDGERNGLEADLDAAMAAGTAPLAIINDILLDGMKVVGELFGSGQMQLPFVLQSAEVMKTAVAYLEPHMEKADDGGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPISAILDAAEQHRADAIGMSGLLVKSTVIMKENLAEMASRGVAERWPVLLGGAALTRAYVEDDLRSMFPGQVHYARDAFEGLSLMDRVMTAKRGGAPVIDPEREAALAARRARRERQRAVVAESLPELTDTSVRSDVAADVPVPTAPFYGTRVVKGVPLADYAALLDERATFMGQWGLRGARGGKGPSYVELVETEGRPRLRYWLDRLIADQVLEAAVVYGYFPAYSEGNDLVVLDENGHAERARFTFPRQRQERRLCLADFFRPRGEELDVVALQLVTVGQPVSEYAAKLFARNEYRDYLEVHGLSVQLTEALAEYWHKRVRAELTLPDGRTVADDDPTDLAGLLRTDYRGCRYAFGYPACPDLEDRAKIVELLGAERIGVQLSEEFQLMPEQATDAIVVHHPEASYFNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Q5</accession>
    <name>F4F7Q5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734344.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22960"/>
    <dbReference type="EnsemblBacteria" id="AEB45692">
        <property type="protein sequence ID" value="AEB45692"/>
        <property type="gene ID" value="VAB18032_22960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22960"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_8_0_11"/>
    <dbReference type="OMA" id="FPGGESM"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022492">
        <property type="entry name" value="Phosphomutase_MSMEG4193_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03848">
        <property type="entry name" value="MSMEG_4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="234" mass="24799" checksum="DC69247105E74E4C" modified="2011-06-28" version="1">MATLLLLRHGRTTANADGGLAGRQPVDLDETGQAQATAVGERLRALPLAAVVSSPLVRCRRTLELALPQASPVPDDGLIECGYGTWEGQPLKKLAKEPLWPVVQQHPSAAVFPEGESMAQMAARAVATVRAWDARVTAEHGPEAVWLACSHGDVIKAIVADALGVHLDLFQRIVVDPASVTAIRYTPLRPFLLRLNDVGGDLAGLVPPQRKRRRRASRPTDSDAAVGGGAGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7S0</accession>
    <name>F4F7S0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734359.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23035"/>
    <dbReference type="EnsemblBacteria" id="AEB45707">
        <property type="protein sequence ID" value="AEB45707"/>
        <property type="gene ID" value="VAB18032_23035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23035"/>
    <dbReference type="eggNOG" id="ENOG50323KX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2587625_0_0_11"/>
    <dbReference type="OrthoDB" id="2208032at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="78" mass="8597" checksum="226B65AED882B20E" modified="2011-06-28" version="1">MTDLYPAADDREVLREAAARHTTAVRDVEAFLRRLPEVPDPADLTEYANLITREEQARADRQAAADAAGLDFPSLGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8K3</accession>
    <name>F4F8K3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat protein coth</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734398.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23240"/>
    <dbReference type="EnsemblBacteria" id="AEB45746">
        <property type="protein sequence ID" value="AEB45746"/>
        <property type="gene ID" value="VAB18032_23240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23240"/>
    <dbReference type="eggNOG" id="COG5337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021844_0_0_11"/>
    <dbReference type="OMA" id="NYYLWYD"/>
    <dbReference type="OrthoDB" id="688261at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="565" mass="59660" checksum="750A6B02C8A8FFDA" modified="2011-06-28" version="1">MRWKHRIPVRIRHYWKFLAGCLAFALVLAVTLSSVPIRPYVTSTSASGGDLVTQNIAGTVDLFDETVAHRIELVFRDADYERMLDAFYAEGEKEYLEADLVIDGTAIPSVGIRLKGNSTLRSLTRNGQTPQRGGGPDGPEGPGGTDGQRWPGGQNGPRGPGWPGGQAGPGQFGPPDGVQGPPGGAQVPPGGQTAPDGQAGPGGQVAPGGLSRTSLRAEEPETLPWLIRFDEYVEGRRYQGHREIAVRVAGMGGGTTVLNEAVTLNLLAAAGEVAQEYAYTSFTVNDRPTTARLVVEHPDEHFAEDFDTAGVLYKALATSEFADQGDDQTAYADDFKQITMKGSQDLQPVIDLIRWVDTASDSEFDEQLADRLDVTSFARYVAWQNLLLNFDDMSGPGRNYYLWYDLGAKRFTVIGWDHNLAFSGSAEQGPHEQGRFGGGRSNAGGAGPGGAGPGNGGPGGAGPGGAGPGNGGPGGAGPGGGGHKLKERFLASEKFTQLYEDTYRDLYQRVYGDGAALAAVDAISGVLATVDGYDASAATGDAQRLRTLIEQRTASLATNEVITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8M2</accession>
    <name>F4F8M2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme glgx</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_23335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734417.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23335"/>
    <dbReference type="EnsemblBacteria" id="AEB45765">
        <property type="protein sequence ID" value="AEB45765"/>
        <property type="gene ID" value="VAB18032_23335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23335"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_11"/>
    <dbReference type="OMA" id="WGNDFGR"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="160"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="705" mass="80235" checksum="0FB5CF56F65FEC07" modified="2011-06-28" version="1">MQVWPGERFPLGATYDGMGTNFAIFSEVAERIELCLFDEWDVGHERRVELREVDAYVWHAYIPGIGPGQRYGYRVHGPYDPANGLRCNPHKLLIDPYAKAIDSEVRWDPAVYDYTLGDPERMSETDSAPFMPKSVVVNPYFDWGNDAPPRTPYHRSVIYEAHVRGLTMRLPGIPEELRGTYAGIASPPMIEHLTRLGVTAIELMPVHQFVNDHRLADLGLRNYWGYNTIGFFAPHHGYSALGHLGQQVQEFRGMVKALHAAGIEVILDVVYNHTAEGNHLGPTLSFKGVDNPSYYRLSEENRQYYVDYTGTGNSLNVRNPHSLQLIMDSLRYWVTEMHVDGFRFDLAATLAREFYEVDRLSTFFEVVQQDPVVSRVKLIAEPWDVGPGGYQVGNFPPQWTEWNGKYRDTVRDFWRGEPATLAEFASRICGSADLYQDDGRRPFHSINFVTCHDGFTLADLVSYNDKHNEANGEDNRDGESHNRSWNCGVEGDTDDPGVLALRARQQRNFIATLLLSQGVPMIGHGDELGRTQRGNNNAYCQDSELAWIDWDNVDHDLLDFTRRLVAFRRRHQVFQRRRFFTGLPVRGREVDEPLPDLAWYTPDGREMTGEDWGNDFGRSVALFVNGDGIRERGQYGQRHHDTSFWLCFNAHDAPLDFTPPPAEFGQRWELVISTAEPDQDKGTTVEAGGTVCVPDRSLVVLERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8M4</accession>
    <name>F4F8M4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_23345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734419.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23345"/>
    <dbReference type="EnsemblBacteria" id="AEB45767">
        <property type="protein sequence ID" value="AEB45767"/>
        <property type="gene ID" value="VAB18032_23345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23345"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="OMA" id="LMREVWD"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="24516" checksum="711F8CBBAEEED208" modified="2011-06-28" version="1">MRVLLVEDDLRVSAGLASALRRRGHEVVQALTAAEAAEAEPVDLILLDMNLPDRDGLEVCRRIRQHNEEVAIIAVTARAEEHDRVAGLRAGADDYVVKPFSMVELQARIDAVMRRTGRAVRATTALQIGPLRIDVDARRVWIYEREVALSRKEFDLLVALARQAGTVVPRDRLQLEVWQTTWATRHNLDVHVAALRGKLENPQLVETVRGVGYRLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F989</accession>
    <name>F4F989_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731954.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10825"/>
    <dbReference type="EnsemblBacteria" id="AEB43283">
        <property type="protein sequence ID" value="AEB43283"/>
        <property type="gene ID" value="VAB18032_10825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10825"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_4_2_11"/>
    <dbReference type="OMA" id="MIEDRNY"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="155" mass="16713" checksum="5577DE8383CD0851" modified="2011-06-28" version="1">MSPIGKTRPTGRDRLRDSVLAGDLSFLLARANALTLAAANAALAEHGLKARSYSVLALAADDVRPTQRELAEFLRLDPSQVVALVDGLEKRQLVERQTDPADRRANVLVATDAGRALFAQAQESARAVELGLLAAVTPQDHERLAQLLRLLAFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9A0</accession>
    <name>F4F9A0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10880"/>
    <dbReference type="EnsemblBacteria" id="AEB43294">
        <property type="protein sequence ID" value="AEB43294"/>
        <property type="gene ID" value="VAB18032_10880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10880"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_10_11"/>
    <dbReference type="OMA" id="RTFHHLY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="23600" checksum="1CA967814F92DD4C" modified="2011-06-28" version="1">MTVPKLSDHDERRGQILAALLRIAASRGLHAASMRTVAAEAGVSVSTVQYYFHSKEQLLFAGLRHQAEMVGRRVAGSMPTGAGRDGVRAWLVQIIPVDVEQRAAYTVFAAYHALALTDPALAELSYSRYSRDLEALLGDLLRAAQRAGEVSDECDVEAEAVNLLALATGLADGVMAAMRTPEAALALLDYQLDRLFAGAQRPASARSTERCDTPEVASMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9C3</accession>
    <name>F4F9C3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731988.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10995"/>
    <dbReference type="EnsemblBacteria" id="AEB43317">
        <property type="protein sequence ID" value="AEB43317"/>
        <property type="gene ID" value="VAB18032_10995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10995"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_3_11"/>
    <dbReference type="OMA" id="PGPYGCL"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="192"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="378"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="540" mass="56509" checksum="49D349375DC4CE57" modified="2011-06-28" version="1">MTERIEGHGGELALAALRAYGVREMFTLSGGHVFPLYDAAHKTGFPLYDVRHEQSAVFAAEAVAKLQRRPGLAVLTAGPGVTNGISGLTSAYFNASPVLVMGGRAPQFRWGSGSLQEMDHLPLVAPVTKHAETVFSADDIPRAVAAALTTALTPHRGPVFLDFPLEAIFSTGDADLPAGPALDPVEADPDEVAKAAGLIAGAQRPVVIAGSDVYAGDAVAALRAAAEALDVPVFTNGMGRGALPPEHPLAFAKARRVALKGADVVVVVGTPLDFRLSFGDFGDATVVHIVDAPSQRATHVQPAVAPAGDLRAILTTLAGYTGDRADHTDWVAQLRTAEDAAKARDAEEMAAETDPIRPARVYGELRKVLARDAITIGDGGDFVSYAGRYLEPAQPGTWLDPGPYGCLGTGMGYAMGARVTHPDRQICVLMGDGAAGFSLMDVESLVRQKLPVVMVVGNNGIWGLEKHPMRAMYGYDVAADLQPELRYDQVVTALGGAGETVAKAADLGPALQRAFDAGVPYLVNVITDPADAYPRSSNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9T4</accession>
    <name>F4F9T4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734512.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23810"/>
    <dbReference type="EnsemblBacteria" id="AEB45860">
        <property type="protein sequence ID" value="AEB45860"/>
        <property type="gene ID" value="VAB18032_23810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23810"/>
    <dbReference type="eggNOG" id="ENOG5032W8F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155306_0_0_11"/>
    <dbReference type="OMA" id="TARHFPY"/>
    <dbReference type="OrthoDB" id="1585000at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="14981" checksum="2C22E9C79AB829CC" modified="2011-06-28" version="1">MSRRRFEFRFDPPWRPVLALLGVRPSTAWVDVDADEVTVRFGPWRLRTTRDNVTGVQESGPYRWWRAIGPHLSAADVGVTFGSSTARGLCIRFGRPVPALLPGRWLRHPAMTVTVADPDALAHALAAAPDGGVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAA4</accession>
    <name>F4FAA4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ordered locus">VAB18032_05195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730839.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05195"/>
    <dbReference type="EnsemblBacteria" id="AEB42165">
        <property type="protein sequence ID" value="AEB42165"/>
        <property type="gene ID" value="VAB18032_05195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05195"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_11"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="232152at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="299"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="331"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB42165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="429" mass="46983" checksum="20827EE3E22F2A15" modified="2011-06-28" version="1">MPAIVLIGAQWGDEGKGKVTDQLGERVDYVVRYSGGNNAGHTVITPDGQKYALHLMPSGALSPNAVIVIGNGVVVDPKVLLSEIDGLAERGVDVSRLRISGDAHLIMPHHRALDRVVERYLGSSRIGTTGRGIGPAYGDKVARMGIRVQDLLDPGILRKKLELALREKNQVMFKVYNRKAIDLDATIEEYLEYAERLRPYIAETRSMLWDALDRGDTVLLEGAQATMLDMDHGTYPFVTSSNPTAGGACVGAGIPPTAITKVIAVSKAYTTRVGSGPFPTELFDDNGAHLRKVGHEYGTTTGRERRCGWFDAVVARYACRLNGVTDLVITKLDVLTGLATVPICVGYEINGKRVDDMPMTQTDFHHATPIYEEHDGWWEDITKARTEEDLPDNARRYIARIEELCSTKVSVVGVGPGREENVTRHPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAC1</accession>
    <name>F4FAC1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNARE associated Golgi protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730856.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05280"/>
    <dbReference type="EnsemblBacteria" id="AEB42182">
        <property type="protein sequence ID" value="AEB42182"/>
        <property type="gene ID" value="VAB18032_05280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05280"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_2_2_11"/>
    <dbReference type="OMA" id="CCVIDGF"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="22443" checksum="25672B545B396069" modified="2011-06-28" version="1">MEAAIDLLRQTLTSPWVYLLLFGLTTVDAIFPLVPAEAAVITATVLATGGEPNLALLLVVATLGAAAGDHLSYAVGRGGGSRKLDHSPVDSRRRAGSEWARRAVDRRGGMILVAARYVPGGRTAVTLTMGAVRYPLRSFLLFDLIGSVTWAFYCVLLGVFGGLAFERHPLHGILAGIGLSLVITLGLELIRWLRHHAHRRAARGVDREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAS6</accession>
    <name>F4FAS6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733346.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17945"/>
    <dbReference type="EnsemblBacteria" id="AEB44691">
        <property type="protein sequence ID" value="AEB44691"/>
        <property type="gene ID" value="VAB18032_17945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17945"/>
    <dbReference type="eggNOG" id="ENOG5030KHX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692455_0_0_11"/>
    <dbReference type="OMA" id="WADLWSR"/>
    <dbReference type="OrthoDB" id="706113at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="465" mass="48289" checksum="17CCB3E58DBD5238" modified="2011-06-28" version="1">MLSTQLAQLQENVPVGLADADAVVAGFDDALVGGFARIGDEAAAALAALAGAVAGTPLHDRVAEAVAKVTAGSFSQEDLAALAGARSALLGAAHDALLGQFDAAVGRERTPWSAPVGVPAEVSAPRGAARAWLHETAVAGWRGVDHDLLSAVGTPVEAALAEPGLRRLAVLLDGIAAELRASLPVAMMAQVPARRWADLWSRAVLLAQDWSVPDGDVETITGRLLPLGVDIHEHGTAIGVQVHGVLEPADGGAVRLVRTTVVAAKVETITGPAVWRLLQAHPVLLAALAQRRAVTVTDLPLHGGDLRWIEAQARVGEPADPFAAARLLLGTAVAAATAPLDRHPTAIAEPVLLEGYTVRQDDDRLTVEWDGRQLPVAVDRLPAAGPLTPALVAASSCCVGLLRFDGGRWLVQPLAVQATVKRKPVEAHNGDWAEGITDPKVAKVEAKAGDAVAVLRERAGRLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAW1</accession>
    <name>F4FAW1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45924">
        <property type="protein sequence ID" value="AEB45924"/>
        <property type="gene ID" value="VAB18032_24130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24130"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2356568_0_0_11"/>
    <dbReference type="OMA" id="WTTRRQQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="11411" checksum="4D56BA9853AFC34C" modified="2011-06-28" version="1">MVMPWPWPMPDDHSFRALWDAPQDHDEDVRLAALVAQRLSADWSTRRQQITVMVQNRVVILTGLVAGAETRRAAGELAWDVEGVADVCNALRLAGHRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAY0</accession>
    <name>F4FAY0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24225"/>
    <dbReference type="EnsemblBacteria" id="AEB45943">
        <property type="protein sequence ID" value="AEB45943"/>
        <property type="gene ID" value="VAB18032_24225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24225"/>
    <dbReference type="eggNOG" id="COG5502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121888_1_0_11"/>
    <dbReference type="OMA" id="IHVRAVF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="157" mass="16801" checksum="FFFE57E8FD966A31" modified="2011-06-28" version="1">MPVTALGRRLLGRCAGTRRIRSEKGAGQVDDNEFIDSVASRTGASAEQATAIARATLTTLAERIDGGQARDLADQLPEGLRAYTFAPHEDAERFGLDVFVQRVGGRADVDPELAEAGIRAVLDTIRAATTADEYDDVIAHLPAELWQVADPVPPYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB20</accession>
    <name>F4FB20_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AlkA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00405"/>
    <dbReference type="EnsemblBacteria" id="AEB47165">
        <property type="protein sequence ID" value="AEB47165"/>
        <property type="gene ID" value="VAB18032_00405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00405"/>
    <dbReference type="eggNOG" id="COG0122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_72_6_11"/>
    <dbReference type="OMA" id="RWPDAFP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="423" mass="44917" checksum="A626F6F34B450EDD" modified="2011-06-28" version="1">MVGRAMRLIADGVVDRDGVPGLAARLGYTERHLHRMLRAELGAGPLALARAQRAQTARTLIESTELGLAEIAFAAGFGSVRQFNDTIREVYGVPPSQLRAGRRTALGGSGTITLRLAYRPPLHAPALLEFLALRTLPGIDEVRDGTYRRGLRLPHGTGAVALTPADGHVAATLRLTDLRDLAPAVARCRHLLDLDADPVAVDQTLSADPALAAAVAAEPGVRVPHAVDGFEMAVRAITTQQVSLTSARTTLTHLLTTLYTPALKSVDQEVCVGDGAREDANLLINGAEGVSVGEEGVRVGGFPAAEEVLRVPDEGFRMPAGRREAIRAVARAVVAGELDLEVGGERGEVARRLARVPGVGPWTGGYIAMRALGDPDVFMPTDLAVRRGAAALGLPDSPAALDEYATRWRPWRSYAVVRLWRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB91</accession>
    <name>F4FB91_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Copper resistance protein CopC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_00760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735881.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00760"/>
    <dbReference type="EnsemblBacteria" id="AEB47236">
        <property type="protein sequence ID" value="AEB47236"/>
        <property type="gene ID" value="VAB18032_00760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00760"/>
    <dbReference type="eggNOG" id="COG1276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023176_0_0_11"/>
    <dbReference type="OMA" id="MLRGPYE"/>
    <dbReference type="OrthoDB" id="1753926at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307775" evidence="9">
        <location>
            <begin position="37"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="10">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="11">
        <location>
            <begin position="328"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="551" mass="56420" checksum="FF58E0DCB0B4059A" modified="2011-06-28" version="1">MPTRTRAGVLLGLVLATCCATLGAVLGAAGPAAAHAVVVATTPQRDEVLGYAPREVLVTFSEPVAVVPGRVQVLAPDGKRINVGDPEVRDRTMRIALRAADRPLGTYLVSYRVVSADSHPISGSFTFAAGAPSATPPLPADAGAGSPAGILVPVAKYVGYLGLLLAVGPPLLATSMWPRRRSRRAATVLALVGLGLVAAATVGTWIGQAAQVVGAPVGRLSPADLRAVADSDIGLVLAVRLALVGLAAALLPAVTRGTAGRVRTGALAVVGVAGLTTWPLAGHPVAAPVPAVSIVLTTVHVAGITVWLGGLLALTVFLLRGTHERVLARILPAWSRWATVAVAWLVTAGLIQAAIELGRPSALLDSAYGRLLGAKAALLAVVLAVAAGQRRLIRRRAAAAQPRRVARAAGVELAVTAVVLALTALLVQTPPGRTAGTAAAGVTREGVAQSLTTDLFTLQFDIYPAAAGTTNSLHAYVYTPQAQELPVAEWTITAALPEAGIEPITVEVFALEPHHGSAEIHFPVAGDWTLRIAARTSDIDRSTATTTVTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBL7</accession>
    <name>F4FBL7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732148.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11825"/>
    <dbReference type="EnsemblBacteria" id="AEB43479">
        <property type="protein sequence ID" value="AEB43479"/>
        <property type="gene ID" value="VAB18032_11825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11825"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_4_0_11"/>
    <dbReference type="OMA" id="YGIMQEV"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="110" mass="12146" checksum="89C00D654D953AEA" modified="2011-06-28" version="1">MTEPAFFILTALLDAPRHGYGIVAEVADLSQGQVQLKIGSLYGVLDRLVGDGLVELDREEAWQGRLRRYYRVTEQGRATLAAEAHRLAANARLASTRLHEQRNPITGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBT9</accession>
    <name>F4FBT9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellulose-binding family II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733394.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18185"/>
    <dbReference type="EnsemblBacteria" id="AEB44739">
        <property type="protein sequence ID" value="AEB44739"/>
        <property type="gene ID" value="VAB18032_18185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18185"/>
    <dbReference type="eggNOG" id="COG5520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022864_2_0_11"/>
    <dbReference type="OMA" id="WSRYIRP"/>
    <dbReference type="OrthoDB" id="249425at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307783" evidence="5">
        <location>
            <begin position="36"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="6">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="570" mass="61000" checksum="DA1BF50E7869E329" modified="2011-06-28" version="1">MRHVKDRFRVNAARVTTGAVLLASAAVTVALPAGAAAAGCSATYAVSSQWQGGFGANVTITNLGDPVTSWTLNWNYGAGQRVAEAWNATVSQSGAAVTARNVGYNGTIPTNGSTSFGFNGTWSGSNPDPTSFTLNGVTCTGSTTPTTPPPTTPPPTTPPPTGPADITVNSTTRYQTVDGFGAATPIWGGTWSTSDTQTLVGLGANQLGLSIVRTGISPVSSEWSSQVNALRTAKSAGSNVKILASPWTAPAEWKTNNSRINGGKLRTDRYADYANHLNSYVQYMRNQGVTIDVTSVQNEPDWHPDYDSMDWSGTELRNFVRDHGTRVQNTRLMVAEAVNLNYTYTDPTLNDATARNNIGYIGGHLYGTEASGRLRSYPLADQHNKPVWMTEWNLHAADGNGSNIWGNPANLAVWNETLDDIMRTVHRSMESNWTAYIWWYGKRYYSFIGDGEAAFGTTAGAPLKRGYAFSQYAKYVRPGYQRVALTKSTKANPLEVTAYTGGGKTTLVILNRSTSAVNNAVIQVPQNVTRAEHYLTSQNANAASQSVGVNGGQVSVNVGARSISTVVLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBV1</accession>
    <name>F4FBV1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase E1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733406.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18245"/>
    <dbReference type="EnsemblBacteria" id="AEB44751">
        <property type="protein sequence ID" value="AEB44751"/>
        <property type="gene ID" value="VAB18032_18245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18245"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_11"/>
    <dbReference type="OMA" id="EYECTPK"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="5"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="34755" checksum="27424EDC93B01C1B" modified="2011-06-28" version="1">MSESLRYIQAVNAALTWALDSRSDTVYFGEDVALPGGPFGATKGLHKRFGSERIFDTPISETGFLGMALGAAMTGLRPIAEIMYADFSFVAMDQIVNQIANIRYSSAGRWKAPLVIRMQQGYSPGACAQHSQSIEAYLAHTPGLRVALPSTPDDAYQMLRTAVVSDDPVVVAEARMLYPTRGPVRTDAPVEPIGGARVVRDGRDATVVAWSRMVPAALAAADELAAEGIETEVIDLRWLNPLDFETVGASISRTGRLVVAHEANLTGGFGAEIAARAASECFTDLRAPVARVAAPDVPMPAAPALQKAVVPEAAHVVEAVRRTVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC20</accession>
    <name>F4FC20_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterol-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734670.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24600"/>
    <dbReference type="EnsemblBacteria" id="AEB46018">
        <property type="protein sequence ID" value="AEB46018"/>
        <property type="gene ID" value="VAB18032_24600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24600"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118604_0_0_11"/>
    <dbReference type="OMA" id="AVMLVMK"/>
    <dbReference type="OrthoDB" id="1982614at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="149" mass="16445" checksum="3AC6E983547B904D" modified="2011-06-28" version="1">MSIHDVRVDVMEPVEFARLVKRTPIEELRQVLHGARRTEILDHLIGGMPAAFRPEVAGRTRAVVHWRIGDRPDGGVDRYEMVIADGVCTLSPRADGTPQLTLDLAAADFVRLVTGNARAVMLVMKGKLQTRGDLALTARFPKLFAAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCX4</accession>
    <name>F4FCX4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18520"/>
    <dbReference type="EnsemblBacteria" id="AEB44806">
        <property type="protein sequence ID" value="AEB44806"/>
        <property type="gene ID" value="VAB18032_18520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18520"/>
    <dbReference type="HOGENOM" id="CLU_2903052_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="62" mass="6434" checksum="9FD17C76A990444F" modified="2011-06-28" version="1">MRALAALTASIVVRTRGDAVEVGRPAATTSTAAMIGESIQLSMVLLHSGRYGSIKCRCLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCY3</accession>
    <name>F4FCY3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733470.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18565"/>
    <dbReference type="EnsemblBacteria" id="AEB44815">
        <property type="protein sequence ID" value="AEB44815"/>
        <property type="gene ID" value="VAB18032_18565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18565"/>
    <dbReference type="eggNOG" id="ENOG5032TCD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053151_0_0_11"/>
    <dbReference type="OMA" id="SIGCHAG"/>
    <dbReference type="OrthoDB" id="1603080at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="425" mass="41636" checksum="7008F557188BE787" modified="2011-06-28" version="1">MECATGDAVYIGTIGQVVGFFERGIDGILSDIAAAIMGAAVELFANLGDIPTLGDQQLNESIHMQTDWLVVTIAVASLLAAAFRVALERKGQPLTVALLGLVRMVLTVGAAWTVANWLASEADAYSHHLYEEGIKAQLKLIANCGTDGLTAFLLIIVGLLLLIAGCVHVILMYIRLGVMVLLTGTLPLAAAASMSEWGGGWWRKHIAWMVAWLAFKPVVGLIMYSGAAMIGATGDNAKHYKLAGAAVLLMAAVALPALMRLVVPAMATLGSRDSSGTGMAAAGAAAGAVATGAKKIAGAGGQAASAISGKPRPPSGNSAPTGSGSRGSSAGGASGGGSSGGGASGAGGGGGGGAPGGSGDGDSGGSGSRLAAAGTAARRVAGGAIGVAAWTVGQGASAVQKTASGARSTHKHASDIASGALGDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD33</accession>
    <name>F4FD33_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734715.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24825"/>
    <dbReference type="EnsemblBacteria" id="AEB46063">
        <property type="protein sequence ID" value="AEB46063"/>
        <property type="gene ID" value="VAB18032_24825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24825"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_4_0_11"/>
    <dbReference type="OMA" id="WPTIYEG"/>
    <dbReference type="OrthoDB" id="1213908at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="4">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="118"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="38393" checksum="11570FC26DBED8E2" modified="2011-06-28" version="1">MPTSDTITLSQADYVRLLVHGTTAFELLRTALELELFERLEKTAIGLTVDEVATALDVQPQAARVLLLGLSSLGLVEVHEGRHVNTPMVRRKLLRDSHRFLGPLVDIQARVINPAMGDLADAVRENRNVGLRHFDSPGDTLYQRLTAYPELQQVFYANMGDASAKALEQLLGLYDFSGLRHVVDLGGGDGTNAVAIAKRYPDLRVTVFDQPTVTTLAAERVDDPDVASRVAFQPADLLTDPLPTDADAICYLHIFEIWSLERNTELLRRCWEALPEGGVCLVYSFVSRDDGTGPMSAGLVSPYFLTLASGEGMTYSARDMAQAVRDAGFRQVEEHRDLGFSHALVVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDC0</accession>
    <name>F4FDC0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="9" type="ordered locus">VAB18032_01235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735968.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01235"/>
    <dbReference type="EnsemblBacteria" id="AEB47331">
        <property type="protein sequence ID" value="AEB47331"/>
        <property type="gene ID" value="VAB18032_01235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01235"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_1_3_11"/>
    <dbReference type="OMA" id="VLWVFGN"/>
    <dbReference type="OrthoDB" id="1974284at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="14277" checksum="C99CB45DA46D1557" modified="2011-06-28" version="1">MADNKRRGEDADDERLNDEVVSDGADDDATDADEPVTRGGTATRERAKAESADSRSKTRADGEKVGLFGRIARFIREVVAELRKVIWPTRKELLTYTGVVIAFVSMMLAIVALLDFAFAKGVLWVFGNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDJ5</accession>
    <name>F4FDJ5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoN</name>
        <name evidence="8" type="ordered locus">VAB18032_06170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
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        <property type="protein sequence ID" value="AEB42358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
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        <property type="gene ID" value="VAB18032_06170"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="FYIRVIV"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
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            <begin position="306"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
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    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="150"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="516" mass="53969" checksum="ADC474CF0C39CF37" modified="2011-06-28" version="1">MNEFELPPIDYAALAPILIMMGAAVVGVLIEAFVPRRLRHPIQLPLALLAVLAALTMVVFNADKRLITIGVIAIDGPTLFLQGGILVLSAVALLMIGERAIERGGAFVAQAAITADSPDDRRQAQHAGGAGEVYPLVTFAIGGMLIFVSANDLLTMFIALEVFSLPLYLLCALARRRRILSQEAAMKYFLLGAYASAFFLFGLALLYGFTAGLGDRPAGVDFATIHAAVANSTQSPVLLFAGMALVAIGLLFKAAAAPFHVWTPDVYQGAPTPVTGFMAACTKVAAFGALLRVFHVAFEGARWDFTPVLGVVAVLTMLVGAVFAVTQTDIKRLLAYSSIANAGYLLVGVLAPGANGLSGTMFYLVAYGFAVLAAFAVVTLVRDADGEATHLSRWAGLGRRSPLYASVFTFILLAFAGIPLTSGFTSKFAVFGPALEGGQVWLVIAGVLTSMVLAFPYLRVVVMMWLSEPGESTPTVTVPGGLTSAALVIGVIATLVLGVAPGPLLDLASGAAEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDQ1</accession>
    <name>F4FDQ1_MICM1</name>
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        <recommendedName>
            <fullName evidence="2">DUF2231 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06450"/>
    <dbReference type="EnsemblBacteria" id="AEB42414">
        <property type="protein sequence ID" value="AEB42414"/>
        <property type="gene ID" value="VAB18032_06450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06450"/>
    <dbReference type="eggNOG" id="COG4244">
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    </dbReference>
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    <dbReference type="OMA" id="SYRHKIG"/>
    <dbReference type="OrthoDB" id="1566648at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019251">
        <property type="entry name" value="DUF2231_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09990">
        <property type="entry name" value="DUF2231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2231" evidence="2">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="161" mass="16523" checksum="F1505D1BB05A8F39" modified="2011-06-28" version="1">MESRLKVLGHPVHPMLVMFPAALLITAVLFDVIDTAGGPDFLGEVAYWNITVGLIGGLLAAAAGLFDLLAIPAGTRAKRVALTHAAANVAVILLFAAVWVVRLNADSRAAGGALIAIEVVALGILSVSAWLGGELVDRLGVGVDRDAHLDAPSSLRTSGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE60</accession>
    <name>F4FE60_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733584.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44929">
        <property type="protein sequence ID" value="AEB44929"/>
        <property type="gene ID" value="VAB18032_19135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19135"/>
    <dbReference type="HOGENOM" id="CLU_545056_0_0_11"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="500" mass="55053" checksum="D06535D55F314DB2" modified="2011-06-28" version="1">MGAFELHHWLLLSFVTVIFGGVIWMAVLAVDSFRATYGGVAGAVTVEDCVYADTDDGPQWTCSGPFVSADGAVRIDAVKLMPRYGAPWDDGVTVTGRISSPSAGTLHTDGQTWKWATGFTVLLLGIGVYLLRSALRIERQVAPPPVDPELAAISERARAFLTEWDHVLAPSTPAAAAPPPVLAVDAPKRANLAVGKVLIGWLLLVLTIAGTVWHLMEWERRQVASLTGQALGTVTGARLGAEDRIEVAYPDTTGAEWRVRWKPVDPDSYREGGQVPVRYDPAQPYEVMPAYPEFFEIEPRGRTVLVQLILLPGYVLAWAWTWRLGRWLLGACRRGRPAEAWIMVAQLHWGVEPTSFWLELRDADRIWYQRIVWDRRLVRRLAGDPAGGAQLPLSVELRRCPGLRRMYLVDVAGVGRLWPASTARARPPRNYELTPVELHLFGLAESTGRHLAILLALTVLAGGGWLLAGPATAAYLLALIGSYQLWGGGAPWRGFYTLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEF7</accession>
    <name>F4FEF7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoprotease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736034.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01575"/>
    <dbReference type="EnsemblBacteria" id="AEB47399">
        <property type="protein sequence ID" value="AEB47399"/>
        <property type="gene ID" value="VAB18032_01575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01575"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255528_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="22620" checksum="160D32D0DBAE417B" modified="2011-06-28" version="1">MKAILAIETSTKDYSVAIGTESAASVRLTTTRFEPDFDGIAGLVDKALAEAGIRSSDLAAVAVDIGPGNLTSVRAGVAYANGLAYALDLPIFATDSLSVMAHSVPADAPVLALRPARGVASSEVYAGIYVPGRPASLSRGDYWVIIDELATSLAEQGFDALTVVGAYRPEMTDVSTSLKVQDGGPAAPDASTLLAMAQAGEERMSPGPVGPLTEESETFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEI7</accession>
    <name>F4FEI7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736064.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01725"/>
    <dbReference type="EnsemblBacteria" id="AEB47429">
        <property type="protein sequence ID" value="AEB47429"/>
        <property type="gene ID" value="VAB18032_01725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01725"/>
    <dbReference type="eggNOG" id="COG4627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104148_0_0_11"/>
    <dbReference type="OMA" id="CDGASIF"/>
    <dbReference type="OrthoDB" id="1193902at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="241" mass="26115" checksum="7F693E17F9534D8A" modified="2011-06-28" version="1">MVALAHTPPSAERLRAVDGFLTEAWADQVGHDDRLRSLRVEVRFDRGVAHLTGEVDEPAQLRLVRDQVGRLAGVFGIWCRVRVGGRDPVVVDLGCGATKQWPGNLGLDIFPAPGVDAVADLSGSLPLADGSVDVLFAVHILEHLIDFLPLLDECHRVLRPGGVLHVMSPWWGHVNAVADPTHVRLLDVQTIKGVCVMRPPGTPRWYPLHAGTDGASIFADLTPLGPDDEGPSPTHLARFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEP7</accession>
    <name>F4FEP7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06585"/>
    <dbReference type="EnsemblBacteria" id="AEB42441">
        <property type="protein sequence ID" value="AEB42441"/>
        <property type="gene ID" value="VAB18032_06585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06585"/>
    <dbReference type="eggNOG" id="ENOG502ZBU7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035969_1_1_11"/>
    <dbReference type="OMA" id="PEWVPWS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="28921" checksum="77DB274944E94FDE" modified="2011-06-28" version="1">MTRPVSARAARLDQVCAAAVEVARAGITEVDATEVGEHLQAVAEGDRLVTHYFECLLAGYRGWRWAVTVTRVPRSRTVTICETVLLPGPDALLAPGWLPWQERLKPGDLGPGDLLPTPADDERLAPGYLLSDDPAVEETAWELGLGRARVLSREGRAEAAQRWYDGDHGPSAPISTSAPAAARCGTCGFYLPLAGQLRQCFGVCGNFYAPDDGRVVSTDHGCGAHSETLVEAETAVEEVPAVYDDSAVEPMSVSRAPGSVESGEPAEPYGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF00</accession>
    <name>F4FF00_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bioB</name>
        <name evidence="16" type="ordered locus">VAB18032_12990</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732380.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12990"/>
    <dbReference type="EnsemblBacteria" id="AEB43712">
        <property type="protein sequence ID" value="AEB43712"/>
        <property type="gene ID" value="VAB18032_12990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12990"/>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_2_1_11"/>
    <dbReference type="OMA" id="AMGVHRY"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="52"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB43712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="331" mass="35862" checksum="A923B8AAB71083E3" modified="2011-06-28" version="1">MPEILDQARNQVLEGGVGLDQAGVLAVLNLPDEHLTATLQLAHEVRMRWCGPEVEVEGIVSLKTGGCPEDCHFCSQSGLFTSPVRSVWLDIPSLVKAAKQTAATGATEFCIVAAVRGPDARLMKQMREGVAAIKAEVDIQVAASLGMLTQEQVDELVDMGVHRYNHNLETCRSYFPNVVTTHSWEERWETLRMVRESGMEVCCGGILGLGETVEQRAEFAAQLAELDPHEVPLNFLNPRPGTPLGDRPVVEGKDALRAIAAFRLAMPRTILRYAGGREITLGDLGTRDGLLGGINAVIVGNYLTTLGRSATDDLKLLDDLKMPVKALSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF08</accession>
    <name>F4FF08_MICM1</name>
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        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732388.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13030"/>
    <dbReference type="EnsemblBacteria" id="AEB43720">
        <property type="protein sequence ID" value="AEB43720"/>
        <property type="gene ID" value="VAB18032_13030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13030"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_4_0_11"/>
    <dbReference type="OMA" id="MHPYELG"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="198" mass="22971" checksum="395894C80352CAE0" modified="2011-06-28" version="1">MERRRKVPNPLALAVLAWLLWEPMHPYELGRRLKQAGQDRQIRYTRSSLYMVMEQLTRAGFVAPQETVRDSARPERTVYAITDEGRHEVHDWLRTLLAQPRQEYPHFAVALSLLSLLPPDEAVEVLRRRSAALAGQIEETRTTVAEARADGLAWIYLVEEEYSLALLEAERRFVADLIESLKQPDYARSWQETMGDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFA0</accession>
    <name>F4FFA0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733660.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19515"/>
    <dbReference type="EnsemblBacteria" id="AEB45005">
        <property type="protein sequence ID" value="AEB45005"/>
        <property type="gene ID" value="VAB18032_19515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19515"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OMA" id="AKREIYQ"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="263"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="512" mass="55965" checksum="18025E9A2872793F" modified="2011-06-28" version="1">MDDHILEMRRITKTFPGVAALQDVTLAVRRGEIHAICGENGAGKSTLMKVLSGVYPSGSYSGEILLDGKPVDFRGIRDSEAHGIVIIHQELALVPYLSIAENIFLGNERRGRSGLIDWNRTNAEAAKLLASVGLHENPVTPVVQLGVGKQQLVEIAKALSKEVKLLILDEPTAALNDVDSAHLLNLMRRLRDQGITCIMISHKLNEITAIADSTTVLRDGRTVERLEMGSGEVNQERIIRGMVGRDLDSFYPDRVSSPGAEVLRIEDWTVRHPTQDRLVVDGASLDVRAGEVVGIAGLMGAGRTELAMSVFGRSYGRDISGRLYMHGKEIRARSVSEAIGNGIAYATEDRKRFGLNLIDDIRHNVSSAGLRRLARAGWVHDNEETRVAESSRRDMNIKAPSVLSVVGKLSGGNQQKVVLSKWLFTDPDVLILDEPTRGIDVGAKFEIYTIINQLVADGKAVIMISSELPELLGMCDRIYTLSAGRITGVLPAAEATQEKLMELMAKDKESVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFB9</accession>
    <name>F4FFB9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19610"/>
    <dbReference type="EnsemblBacteria" id="AEB45024">
        <property type="protein sequence ID" value="AEB45024"/>
        <property type="gene ID" value="VAB18032_19610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19610"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_17_1_11"/>
    <dbReference type="OMA" id="PRSYLLW"/>
    <dbReference type="OrthoDB" id="1919220at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="39971" checksum="43FEE2B5FCDB3B9B" modified="2011-06-28" version="1">MPGAYWAWLGGTTLSLIGVQAMAFAMAWVAAGAGGGFAALVLTAVNLPRALLLLVGGAVADRLGAWTVMVVSDAAMVVVTVALAAAVWSAADPWLPLLLAALAIGVVDAFYLPSTGSMPRRLVPPAGLARAMSARHLAGQLAMFVGPAAGSLLLAALGLAAVALANASSFALMLAVLVVLRAAMGGRPSGSPELPDGQPPSQPLWRAAVDGLRIAASHAVLRPAMLLVGVAAGFLLPVSSLLVPLLGRERTWSSPATSAVVAALALGTATVAILVLVRGALPDPGRASAAALLVAAVGVVTLGAAAGSLSVSVAAGMVIGVGSGGFATHVGPLILAVAPDTHVSRVQSVLVLVQSLPLLLTLNVLGSLAEVVPVAALLYGCAGVLAVAAVTALTSPSLRRADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFR4</accession>
    <name>F4FFR4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetic acid degradation protein paan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736174.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02285"/>
    <dbReference type="EnsemblBacteria" id="AEB47541">
        <property type="protein sequence ID" value="AEB47541"/>
        <property type="gene ID" value="VAB18032_02285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02285"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036377_1_0_11"/>
    <dbReference type="OMA" id="CNTFPTW"/>
    <dbReference type="OrthoDB" id="618655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011975">
        <property type="entry name" value="PaaN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02288">
        <property type="entry name" value="PaaN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="90"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="558" mass="59141" checksum="B6D38164849BBEC6" modified="2011-06-28" version="1">MTDTPHPHYDRHAETLNRALTAITERGYWSAYPESPSPRVYGETAAADGKAAFEAYLGGNFPLDQPTDGKWIATETSPFGVELNVTYPHATADQLVAAASAALPAWRDAGPQTRAGVCLEILDRLHKNVFELANAVQFTSGQAFVMAFQAGGAHALDRALEAIAYSYAEMTRHPGTAGWEKAAGKGDPLRMTKTFHVVPRGVGLVIGCNTFPTWNSYPGLFASLVTGNPVVVKPHPRAVLPLAITVRYAREVLAEAGFDPNLVLLAPEAADEKLATMLALHPAVKIVDFTGSTEYGDWLEANARQAAVYTEKAGLNTVVIDSTDDFAGMCRNLGFTLVLYSGQMCTTSQNILIPRDGIDTDQGHKSFDEVAAGIAAAVGKLTADPARGVELTGAIVNDGVLERLDEVTKVGEPVLESRTVEHPAYPGAVVRTPTIVKLDAGDTATYSREWFGPISFAIATDSTAHSLEILRSTVGEKGALTAAVYSTDESVLAATENAAIEVGVHLSANLTGGVFVNQSAAFSDFHGSGANAAANAALTDGAYVANRFRIVQSRRHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFT4</accession>
    <name>F4FFT4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731187.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42514">
        <property type="protein sequence ID" value="AEB42514"/>
        <property type="gene ID" value="VAB18032_06950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06950"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712498_0_0_11"/>
    <dbReference type="OrthoDB" id="1961636at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="16799" checksum="72829EEE6FD4FA78" modified="2011-06-28" version="1">MAQYIVTITPVLGEKDAGEESSRTTMRVFAEDGQVYIKELTVRVAEDVKLGAADLLQVDLDLLMQAFAAKRPAAPAATAESSDPARAYRAVTPSRVAKSDRAYRRMPDPSELKDIYLKNRTVTGVAKHYGVPTHTAQGWITRLRRKGVIPSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGG2</accession>
    <name>F4FGG2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monovalent cation/proton antiporter, mnhg/phag subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733755.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19990"/>
    <dbReference type="EnsemblBacteria" id="AEB45100">
        <property type="protein sequence ID" value="AEB45100"/>
        <property type="gene ID" value="VAB18032_19990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19990"/>
    <dbReference type="eggNOG" id="COG1320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_0_5_11"/>
    <dbReference type="OMA" id="PISAHMV"/>
    <dbReference type="OrthoDB" id="2051355at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="125" mass="13067" checksum="42889A90A0B559FE" modified="2011-06-28" version="1">MSLDAVLDIVAAVCLISGALLSLAAGMALVRFPDLLARMHAAAKPQVLGLLLVLLGCGLRLRTGVDITTLVLIGVFQLATAPVAAHMVGRAAYPHDDIRTDLLLTDELAPHLDRLSTTTPPTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGH3</accession>
    <name>F4FGH3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26050"/>
    <dbReference type="EnsemblBacteria" id="AEB46308">
        <property type="protein sequence ID" value="AEB46308"/>
        <property type="gene ID" value="VAB18032_26050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26050"/>
    <dbReference type="HOGENOM" id="CLU_3141987_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="49" mass="5113" checksum="66CC74D6471CE878" modified="2011-06-28" version="1">MAQPPLMPAAPYELERADGAYSPVEIAIRRGLGQDTPDLDGVGTDDNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGJ4</accession>
    <name>F4FGJ4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="4" type="ordered locus">VAB18032_26155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734980.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26155"/>
    <dbReference type="EnsemblBacteria" id="AEB46329">
        <property type="protein sequence ID" value="AEB46329"/>
        <property type="gene ID" value="VAB18032_26155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26155"/>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_11"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="OrthoDB" id="143460at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="622" mass="68479" checksum="1980B6E7F937E7B4" modified="2011-06-28" version="1">MQLRTDLRNVAIIAHVDHGKTTLVDAMLRQAGAYGARGEVTERVMDSMDLEREKGITILAKNTGVRYLPADGSDPVTINIIDTPGHADFGGEVERGLTMVDGVVLLVDASEGPLPQTRFVLRKALKARMPIILVINKVDRPDARIKEVVDEAYELFLDLDADETQIDFPIVYACARDGIASLTQPADGSVPQDSTSLEPLFRTLLDTIPPPAYDEQAPLQAHVTNLDASPFLGRLALCRVRQGTIAKGQTVAWCRTDGSTQRVRISELLMTEGLERKPADSAGPGDIIAVAGIPEIMIGETLADAENPQPLPLITVDEPAISMTIGTNNSPLVGRVKGAKVTARMVKDRLDKELVGNVSLRVLPTERPDAWEVQGRGELALAILVEQMRRESYELTVGKPQVVTREIDGKTCEPVERLTIDAPDEYLGAITQLLATRKGRMEQLVNHGTGWIRMEWLVPARGLIGFRTEFLTETRGTGILHHVFESYEPWFGELRTRNNGSLVADRAGAATAFAMMNLQERGTLFVEPGTEVYEGMIVGENSRSDDMDVNITKEKKLTNMRSSTAEETEKLIPPRKLSLEQALEFCREDECVEVTPAAVRIRKVTLDQTQRARATARRKHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGJ5</accession>
    <name>F4FGJ5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734981.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26160"/>
    <dbReference type="EnsemblBacteria" id="AEB46330">
        <property type="protein sequence ID" value="AEB46330"/>
        <property type="gene ID" value="VAB18032_26160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26160"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031960_9_0_11"/>
    <dbReference type="OMA" id="HYAASTM"/>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="291" mass="31252" checksum="D1B289AA576C568A" modified="2011-06-28" version="1">MIFDGLDARLDEVPGTISVYAGRLDAPPTWTRHTEVTHYAASTMKLAVLAAVHHTAETDGPDLDTPVEVTNRFTSARAGAAPFSCAPAYDNDTEVWNRLGQRVPLRWLAERMIVRSSNLATNLLIEQVGLPAVAEIWARVGARHSVTRRGIEDFAAREAGISNLVTAADLAALLDAVATGVTRPGPIASPAGCAAMLDVLCEQQIRQDIAEGLPAGTRLAHKNGWVRGVRHGAAVVFPDDAAPYLLVVCTTTPLDDEQRSQDTDADARELVADISAQVWQARHDLTTADPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGJ9</accession>
    <name>F4FGJ9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="20" type="ordered locus">VAB18032_26180</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
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        <property type="protein sequence ID" value="AEB46334.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:nucleotide-excision repair"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="Helicase/UvrB_N"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="UVR_dom"/>
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        <property type="entry name" value="UVR_dom_sf"/>
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        <property type="entry name" value="UvrB_inter"/>
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        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
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        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UVR"/>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="33"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="437"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="657"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
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        </location>
    </feature>
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        <location>
            <begin position="653"/>
            <end position="699"/>
        </location>
    </feature>
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        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="RuleBase" id="RU003587"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AEB46334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="702" mass="79640" checksum="A100402EF71CE798" modified="2011-06-28" version="1">MALDIPRLDGRFKVISEFQPAGDQPAAIDELERRVRRGDRHTVLLGATGTGKSATTAWLIERMQRPTLVLAPNKTLCAQLAKEFSELLPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKDSSVNEEVERLRHSATMSLLTRRDVVVVATVSAIYGLGTPEEYLDRAVRVAVGQELDRDQLLRRLVDIQYTRNDMAFQRGTFRVRGDTLEIIPAYEELAVRIELFGDEVEKLYYLNPLTGDVVREVDHLLIFPATHYAAGPQRMERAIRDIETELAERLAELERQGKLLEAQRLRMRTTYDIEMMRQVGFCSGIENYSMHIDGRLPGSPPHCLLDYFPDDFLTVIDESHVTIPQIGGMYEGDASRKRMLIDHGFRLPSAADNRPLRFDEFLERVGQMVFLSATPGPWELEHAQGEFVEQVIRPTGLVDPEVVIKPTKGQIDDLMHEIKLRTERDERVLVTTLTKKMAEDLSDYLLENGIRVRYLHSEVDTLRRVELLRELRRGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSGRSLIQTIGRAARNVSGQVHMYADKITPSMADAIDETNRRRAKQIAHNEAHGISPEPLRKKIHDILDDIYREAEDIEATRAGGAVRQLSRGKAPVKETRSRARAGAATPAREGMARAELAQLIQDLSDQMLAAARELQFELAARIRDEVSELKKELRGMDAAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGQ5</accession>
    <name>F4FGQ5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="DUF4032"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF4032"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4032" evidence="1">
        <location>
            <begin position="219"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="396" mass="45073" checksum="322AC24A1F6BAF2E" modified="2011-06-28" version="1">MDPALLDLPWSTPLEQWPAEHLVALPQGISRHVVRFVRLGGYVYAVKETGERVAEREYDLLRALERIDFPSVQAVAIVADRESDSGEPLDPVLITRHLQFSLPYRALFSHTLRPETMGRLLDALAALLVRMHLTGFFWGDCSLSNTLFRRDAGAFAAYLVDAETGALRNGLSNGQRGEDLEIARVNIFGEALDLQAAGLLHDSIDPEVVCEEVVQRYERLWHEITYEQQVERDARHDIEGRIRRLNEMGFDVAEVAMSTIGNGRYLIRPKVVDAGYHHRRLLRLTGLDAEENQARKLLNDLDAYRAESDLTDEQQAAHRWLTEVFEPVVRAVPAHLRRKLEPQELFAQIIEHKWLLSERAGRDVGMRHAVQSFLTEELVHRPDEQAVLGVEIPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGW7</accession>
    <name>F4FGW7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum_form domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736259.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02715"/>
    <dbReference type="EnsemblBacteria" id="AEB47627">
        <property type="protein sequence ID" value="AEB47627"/>
        <property type="gene ID" value="VAB18032_02715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02715"/>
    <dbReference type="eggNOG" id="ENOG5030VN0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080960_0_0_11"/>
    <dbReference type="OMA" id="VRCYLWL"/>
    <dbReference type="OrthoDB" id="1953080at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026004">
        <property type="entry name" value="Septum_form"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13845">
        <property type="entry name" value="Septum_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313042" description="Septum_form domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Septum_form" evidence="2">
        <location>
            <begin position="50"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="298" mass="31721" checksum="6900B608143514E2" modified="2011-06-28" version="1">MQRATRTLTAALAVAAVLAGCGASHGLDGDLTDDWPAMAAPGAFTPAAEVCHEADFADAVPVAAYAPVDCATPHRVETVHVGVFTAERNEPPPIASPELRTAFADCDQRTNGYVGDNWRAGRLRLAVAVPSGAGWAAGSRWYRCDLMEVTTAEAGAKVVTRSGSLRNALRPPSPLWLGCQQARTNRSGVVQALVQVDCAERHNAEFAGVWQAPDRPYPANGAEWAPFYAGCRTVLARYAGLPDSTDLLYRTDLVVRPPSAGRWRAGDRGVRCYLWLSDRQVTGSLKGAGPAGLPVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGY6</accession>
    <name>F4FGY6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731273.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07390"/>
    <dbReference type="EnsemblBacteria" id="AEB42600">
        <property type="protein sequence ID" value="AEB42600"/>
        <property type="gene ID" value="VAB18032_07390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07390"/>
    <dbReference type="eggNOG" id="ENOG502ZMNB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1844264_0_0_11"/>
    <dbReference type="OrthoDB" id="2180489at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="14827" checksum="30E6996EE94CE0BD" modified="2011-06-28" version="1">MRIAEQTKKKAREYRPIGLHSTCDQYAELYTKAAQAAKHLFDVVSGLITKLIDVLIVINLASAVGTATIETGVGPVVGYSVAAYYAWQAYDLYGEISTFFGNAEATFKGIAGTLGMIQAGAAVAALPDLEPYRHPGQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH43</accession>
    <name>F4FH43_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42657">
        <property type="protein sequence ID" value="AEB42657"/>
        <property type="gene ID" value="VAB18032_07685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07685"/>
    <dbReference type="eggNOG" id="ENOG5032631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2482430_0_0_11"/>
    <dbReference type="OrthoDB" id="1994461at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="87" mass="9199" checksum="4BBA252FBB5DFEB9" modified="2011-06-28" version="1">MAGADADGQYLCMAAVESWFIGGPVDGRMMPVETTAAGVLPAVVRMPQAGMYVGASESAAPVLEHLYAQSDRWDDVQVYSYQGIAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH71</accession>
    <name>F4FH71_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pe-pgrs family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732516.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13685"/>
    <dbReference type="EnsemblBacteria" id="AEB43849">
        <property type="protein sequence ID" value="AEB43849"/>
        <property type="gene ID" value="VAB18032_13685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13685"/>
    <dbReference type="eggNOG" id="ENOG50322GU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980669_0_0_11"/>
    <dbReference type="OMA" id="FDADPPW"/>
    <dbReference type="OrthoDB" id="2074659at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="13374" checksum="AC240E8837240F3E" modified="2011-06-28" version="1">MTDRNRQDRGPEGVEPWGTTDGFDADPPWGVGEDSPMDEGSEPTAVAEGRRGERRAGETPREHPPAGRHGFGSVEPTRTPAAGPGAPPDPAPPRRSFPEEVAGEDLPDNALEEATGMRPEGISRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHE4</accession>
    <name>F4FHE4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733771.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20070"/>
    <dbReference type="EnsemblBacteria" id="AEB45116">
        <property type="protein sequence ID" value="AEB45116"/>
        <property type="gene ID" value="VAB18032_20070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20070"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184637_0_0_11"/>
    <dbReference type="OMA" id="TENDHRH"/>
    <dbReference type="OrthoDB" id="1395473at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="234" mass="23624" checksum="41EF38D056179EA1" modified="2011-06-28" version="1">MPRAGELDDVVRLTTRRSWALLTAVLLALGAGTTWAVVARIESTVSLDGILLAGAGPTLVTAPASATVASVSAVVGRPVAAGEVLLTLQGEDDDDAVTVTSPVAGILTTLTARPGTQVKGGATLGVVDRADQRLSALLLLDAGQPAAVPAGAQVRGAGLTGTVTRVEAYPLSTAELAGRYGIGRLPGHDDDRLVRPVLVDLGVSAWPGATLTPIRLDLIVGAERPVDVLLGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHF4</accession>
    <name>F4FHF4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Two component transcriptional regulator, winged helix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_20120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20120"/>
    <dbReference type="EnsemblBacteria" id="AEB45126">
        <property type="protein sequence ID" value="AEB45126"/>
        <property type="gene ID" value="VAB18032_20120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20120"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="OMA" id="GFSACKE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="37"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="159"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="28239" checksum="55CDB9351C6188D8" modified="2011-06-28" version="1">MTGSGDGCPAFGHPPPTVTASDDRGARDYPGYVMDGRVLVVEDDASIREVTALGLRRAGFRVDTAADGRQGLAAWRAGSVDLIVLDVLLPGLDGLQVCREIRRSNAVPILMLTARTDTIDVVVGLECGADDYLRKPFDLPELVARVRSLLRRAVAAPEPGPLRIGRLEIDPGAFVARRDGHELPLTATEFRLLLELARRPGQVFTRELLLERVWEQGYLGDSRLVDVAVQRLRAKVEDDPASPRLIRTVRGAGYKLTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHJ6</accession>
    <name>F4FHJ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, asnc family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733823.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20340"/>
    <dbReference type="EnsemblBacteria" id="AEB45168">
        <property type="protein sequence ID" value="AEB45168"/>
        <property type="gene ID" value="VAB18032_20340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20340"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="OMA" id="AGDENYI"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="17998" checksum="FCAD2719021A7503" modified="2011-06-28" version="1">MEEIDRAIVAALTVDGRLSYTDLAERVGLSVSAVHQRVRRLEQRGVIKGYGAKVSFEALDLPLTAFVAIRPFDPSQPDDAPERLAHLPEIDSCYSVAGEDFYLLLVRVAGPADLERVLQEIRTSANVTTRTTVVLSTPYEHRPPKLALPAEQPRPRGVAAEPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHS3</accession>
    <name>F4FHS3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ordered locus">VAB18032_26846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26846"/>
    <dbReference type="EnsemblBacteria" id="AEB46442">
        <property type="protein sequence ID" value="AEB46442"/>
        <property type="gene ID" value="VAB18032_26846"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26846"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041534_1_0_11"/>
    <dbReference type="OMA" id="WLWDVDY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="45"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="297"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="43850" checksum="25728D89A3135CA3" modified="2011-06-28" version="1">MSRTAAALSRAAGRGDGSVIGGWIGLKIDPDLLAHLSAGRAIALISGTNGKTTTTRLAAAAVGVLGRVATNSFGANMPTGHTSALAKAGSTPYAVLEVDEHYLAQVIEATEPHVVALLNLSRDQLDRAKEVAMMAQLWRAALVRHPDIRIVANADDPMVVWAATPPATHDQRITPPHVTWFSAGQRWHDDSWVCPECGSTIQRSGEQWWCTGCPLRRPQPQWTVDDQGVLDPTGAWYKVKLQLPGKVNVGNAATALAVAAEFGVRPFDAVPRLADVTSVAGRYAQVVRDGRTVRLLLAKNPASWLEAFDMAELAPTLLSINARDPDGLDTSWLFDVDFAPLRGRQVLITGDRAYDLAVRLDVNDVPFQHVRTFDDAVRAVPPGRLEVIANYTAFQDIRAELDRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHV1</accession>
    <name>F4FHV1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736276.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02800"/>
    <dbReference type="EnsemblBacteria" id="AEB47644">
        <property type="protein sequence ID" value="AEB47644"/>
        <property type="gene ID" value="VAB18032_02800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02800"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_0_1_11"/>
    <dbReference type="OMA" id="FSIDTYH"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="300" mass="30600" checksum="119F34080CFE6B29" modified="2011-06-28" version="1">MTDLVRAPAPVVMGVLNVTPDSFSDGGRYADVGAAVAHGVRLRDEGAGLVDVGGESTRPGAERVDPETEVARVVPVIRELAGAGVPVSIDTTRARVAAAALAAGAVVVNDVSGGLADPDMARVVADAGCPWVLMHWRGHSRRMTELAAYDDVVADVRAELGQRVEAALAAGVAADRIVIDPGLGFAKTAAHNWQLSARLPELLELGYPLLFGASRKSYLGLLLAGPDGVPRPTGGRGSATVATSLLAVAAGAWGVRVHDVRATVDALAVWQATGRPRLAPAAGTALAGAGSTGDPQGVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHW5</accession>
    <name>F4FHW5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02870"/>
    <dbReference type="EnsemblBacteria" id="AEB47658">
        <property type="protein sequence ID" value="AEB47658"/>
        <property type="gene ID" value="VAB18032_02870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02870"/>
    <dbReference type="eggNOG" id="ENOG5031XRZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195253_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313964" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="46" mass="4975" checksum="C1A10A9F55797C26" modified="2011-06-28" version="1">MKVSAAMEFLFVLFLLVVLTSASAAGLTADSRDSADWKPSDGGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHY3</accession>
    <name>F4FHY3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736308.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02960"/>
    <dbReference type="EnsemblBacteria" id="AEB47676">
        <property type="protein sequence ID" value="AEB47676"/>
        <property type="gene ID" value="VAB18032_02960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02960"/>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012617_2_1_11"/>
    <dbReference type="OMA" id="YAQAYLG"/>
    <dbReference type="OrthoDB" id="361195at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="572" mass="59360" checksum="51769584C7159F78" modified="2011-06-28" version="1">MSRATGAGAVLRVGNASGFYGDRFSAWQEMLDGGELDVLTGDYLAELTMLILGRDRMRDPDLGYAKTFLRQLEGTLGTALDRGVRIVTNAGGLNPAGLAAAVRSLADRLGLTVRVGYVEGDALARPDALTANAYLGAFGIAACLDGGADVVVTGRVTDASLAVGPAIAHFGWGRDDLDALAGATVAGHLIECGAQVTGGNFSFFTELPDGGHRPGFPIAELHPDGSAVLTKHPGTGGAVTVETVTAQLLYEVGGPAYLGPDVVTRLETVTLDQEGPDRVRVCGVRGTPPPETLKVGINNLGGFRNSMTFVLCGLDIPAKAALVEAQLTESVGPDGLEFTLARTDHPDAVDTETASALLHVHLRDGDKSRAGRAFSAAAVELALASYPGCTLTTLPGDATPYGVFTADTVPQGAVAHVAVLPDGSRVSIPPPPVTCLEGPLIQHQALIRCPSFHSTRRGVLGEVVGARSGDKGGDANLGVWARTDATWAWLRGWLSVERLAELLPETAALRVQRYELPNLRAVNFVIEGLLGAGVAASTRFDPQAKALGELLRARVVDLPAELTAGPASEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F193</accession>
    <name>F4F193_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732596.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14085"/>
    <dbReference type="EnsemblBacteria" id="AEB43929">
        <property type="protein sequence ID" value="AEB43929"/>
        <property type="gene ID" value="VAB18032_14085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14085"/>
    <dbReference type="eggNOG" id="COG4581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017075_0_0_11"/>
    <dbReference type="OMA" id="DEFHFYA"/>
    <dbReference type="OrthoDB" id="66530at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="219"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="834" mass="91978" checksum="C82A7C8ED657D02C" modified="2011-06-28" version="1">MTLTAALPKTADPDTLYDAFAGWASARGLNLYPHQEEAVIEIVSGANVIMNTPTGSGKSLVAIAAHFAALADDRTTFYTAPIKALVSEKFFALCEVFGAENVGMLTGDASVNADAPIICCTAEILANLALREGARADVGQVIMDEFHFYAEPDRGWAWQVPLIELPQAQFVLMSATLGDTTRFVDDLARRTGRSTAVVRSAERPVPLIFTYAMTPLHETLEELLETKQAPIYVVHFTQAAALERAQALMSVNVCTRAEKDMIAQAIGSFRFTSGFGKTLSRLVRHGIGVHHAGMLPKYRRLVETLAQAGLLKVICGTDTLGVGINVPIRTVLFTGLSKYDGVRTRLLKAREFHQIAGRAGRAGFDTLGRVVVQAPEHVIENVKALAKAGDDPKKRRKVVKKKPPEGSIGWGEPTFQRLVEAEPEPLTSSFQVSHSMLLNVIGRPGDAFAAMRHLLTDNHEDPAAQRRHIRRAIAIYRALKAGGVVEELPEPDETGRRVRLTVDLQLDFALNQPLSPLALATIELLDSESPSYALDVLSVIESILDDPRQVLSAQQFKARGEAVAAMKAEGIEYEARLELLDEVTWPKPLAELLNNAYEMYRQGHPWVADHQLSPKSVVRDMYERAMTFTEFVQFYGLSRSEGLVLRYLADAYKTLRQTVPEEAKTDELIDLIEWLGELVRQVDSSLIDEWERLRNPTDLPDVAAALDDRPTAVTRNARAFRVLVRNALFRRVELAALRHWDALGELDASAGWDADAWADALEPYFDTYDEIGTGPNARGPALLMIEQGRERWSVRQILDDPDGDHDWGISAEVDLAASDEAGTAIIRITNVGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F216</accession>
    <name>F4F216_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736395.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03395"/>
    <dbReference type="EnsemblBacteria" id="AEB47763">
        <property type="protein sequence ID" value="AEB47763"/>
        <property type="gene ID" value="VAB18032_03395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03395"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018914_3_0_11"/>
    <dbReference type="OMA" id="GRMWWAV"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="556" mass="61958" checksum="CAA3188F2A3A1AFB" modified="2011-06-28" version="1">MGRIDDIANRYVAEWAALSPTGATYVGISGYDDQLDDLSPDGYAAQADLTRRTLADLDATEPDTEAERIAREAMQERLGLDLARYDTGETTSEVSVITSGLHHSRMIFDLMPTEGAEAQANIAARLSLFAGAMEGYKTTLREAAAKGHVSSQAQLLKVAEQCDAWVDPQGDNVFHGLVERLGAEGALDADLRRGAAAATAAIAEFGQFLRTELAPHGRQKQAAGRERYELASQYFLGARIDLDETYAWGFAELARLEADMRTVAGQILTPGATIDEAVAALDADPTRTIQGKEAFRDWMQQLADQAISELHGTHFDIPEQVRRIECMIAPTSDGSVYYTGPSEDFARPGRMWWAVPQGITDFSTWREVTTVYHEGVPGHHLQIGQTAVRAEMLNRWQRLLCWVSGHGEGWALYAERLMDELGYLEDPGDKLGMLDGQAFRAARVIVDIGMHLELEIPKDNPFDFHPGERWTPELGWEFLREHCRVPDEMLRFELNRYLGWPGQAPSYKVGERIWLQARDDAKTRKGADFDLREFHRQALDLGALGLDPLRRALARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F250</accession>
    <name>F4F250_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731411.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08105"/>
    <dbReference type="EnsemblBacteria" id="AEB42739">
        <property type="protein sequence ID" value="AEB42739"/>
        <property type="gene ID" value="VAB18032_08105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08105"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_2_1_11"/>
    <dbReference type="OMA" id="RPAQRYD"/>
    <dbReference type="OrthoDB" id="2073616at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="15369" checksum="07EA16C1A4FE2F8E" modified="2011-06-28" version="1">MFENLNVWEVGALLLLALLIFGDRLPAVIGDGLRMVRNLRNMARNATTDLSKELGTDIQLEDLHPKAFIRKHLLSEEDEQAIRKPLQGMYDDLRSDVTKVQKDIKDVATAADPRTPGSSATASPPATAPAPRSASYDEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F256</accession>
    <name>F4F256_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08135"/>
    <dbReference type="EnsemblBacteria" id="AEB42745">
        <property type="protein sequence ID" value="AEB42745"/>
        <property type="gene ID" value="VAB18032_08135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08135"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_20_0_11"/>
    <dbReference type="OMA" id="CTHELPA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24354" checksum="1573D3D324605CD5" modified="2011-06-28" version="1">MLFDFFGTLTGPIRRGSGHRATAELLGCPPDAYIDVLDRTFYERASGRFGDAEATLRWVCDQVGVRPSPEALRAAVACRRQAVRADTRLRADAVPTLRALRERGMRTGVISDCTHELPAILPELAVAPLLDVRIFSIQAKRCKPDPALYLAACTWLGLPPADCLYVGDGGSQELTGAQQAGLSAVRLAAPDLVDHLAFNVDNDWGGPALGTLGEVVHLVDGTPVAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F290</accession>
    <name>F4F290_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731450.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08305"/>
    <dbReference type="EnsemblBacteria" id="AEB42779">
        <property type="protein sequence ID" value="AEB42779"/>
        <property type="gene ID" value="VAB18032_08305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08305"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068418_0_0_11"/>
    <dbReference type="OMA" id="GYMRRET"/>
    <dbReference type="OrthoDB" id="834480at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021243">
        <property type="entry name" value="DUF2804"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868">
        <property type="entry name" value="PTHR35868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10974">
        <property type="entry name" value="DUF2804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="36239" checksum="5F49AC3A16C57FDA" modified="2011-06-28" version="1">MTHEKEITEPVDLCLADGRLWPDAVGWSRRPVHRANLRGWGRNKRWEYWGIVTPQHIVGLVASSLDYAGVHSLYVLDRTTKVEIDRGAVVPFARGTAFPPVSGAGEVRARGGGISIDIDQSATGTTIRASAAGIEVDLVVPLPPGHESLGVVVPWSSRRFQYTVKDVGRPVHGTLRVDGVPHVVDDADSFAVLDHGRGRWPYSIRWNWAAGSGPGRAIQLGGRWTDGTGSTENGLFVDGRLHKIGDELRWEYDRADWLRPWRINGERVDVRFHPFHEKVARTNLGVLANETHQCFGHFTGWATTDDGERVDLDGLVGWAEEARNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2I7</accession>
    <name>F4F2I7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ordered locus">VAB18032_14735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732726.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14735"/>
    <dbReference type="EnsemblBacteria" id="AEB44059">
        <property type="protein sequence ID" value="AEB44059"/>
        <property type="gene ID" value="VAB18032_14735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14735"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_3_11"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB44059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="188" mass="19720" checksum="EF9B151BE8FC5397" modified="2011-06-28" version="1">MTETHSSGVRGDSGPDVARLVASRVLDVPDFPKPGVMFKDLMPLFADGAAFRDVIDGIVAYHGRESFDTVVGIEARGFVVAAAIAYATGVGVVPVRKAGKLPRPAYAASYALEYGEATLEVHQDAFTAGHRVLVVDDVLATGGTAAATLDLVERAGGTVTGFTVLLELAFLKGRERLAPRDVHALLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F378</accession>
    <name>F4F378_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03875"/>
    <dbReference type="EnsemblBacteria" id="AEB47857">
        <property type="protein sequence ID" value="AEB47857"/>
        <property type="gene ID" value="VAB18032_03875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03875"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027797_0_0_11"/>
    <dbReference type="OMA" id="FHGHEVC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307635" evidence="1">
        <location>
            <begin position="41"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="378"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="533" mass="57949" checksum="DA77B7FF152A1C93" modified="2011-06-28" version="1">MSGFPARRERTPRRRLVQVAVLATALVLPMLAGPASPAAAADRPAVQPLPAHLETIRAAEATQLYGTPGIRPLAQRRTALITMGDSQISGEGVGNYVPGTHQPGNWCDRSYDQAVFRTGIAADERYNIACSGATPWNLIAGGPTQHNELNQGDHLAIKARNTNIKLIWVVVGANGDGTIQFGPVATDCAVRRVLFQGPCWPTYTDQWTVRTDGSRRAVEDALTDIRRTMTGAGYLNTDYELVLMSYSSPASPDVEDNPNFPGWYAGGCLLYLADAAFARNKAVPLFESALRAAAANTGTRYLDGSRLFHGHEVCTDNTSVRGLYIELGVWDENAARQSFHPNYRGHGMFAQCITQFYASGQQQGTCVDPASTGNGVLYPGLMQFKQLRNAATGTCVDGKGYDSRNNTAQQSYRCHGGRNQGFWYDPTRQSLHSELSHDRCLDVSGGSLTSGTTVNIYDCHGGNNQKFVFSGNQIRAAGNTNLCLAFDNPLLGTPRLRLANCSSSSRQQWSFESRSFAQPVGYGYDDFIGSRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F396</accession>
    <name>F4F396_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ordered locus">VAB18032_08510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731491.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08510"/>
    <dbReference type="EnsemblBacteria" id="AEB42820">
        <property type="protein sequence ID" value="AEB42820"/>
        <property type="gene ID" value="VAB18032_08510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08510"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_0_11"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="234"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="35460" checksum="BCFC72AC8B1237AD" modified="2011-06-28" version="1">MGSIVAENRKSLMLFSGRGFPELAKEIGEVLGVAPTPADAYEFANGEIFVRFKDSVRGSDAFVVQSVTHGVNTWVMETLIMVDALKRGSAKRITVVLPFYPYSRQDKKHRGREPISARLVADLLKTAGANRILTVDLHTAQIQGFFDGPVDHLFAMDILAEYVERRYAGRPMTVVAPDSGRVRVAERWTDRLGGCPLAFIHKTRDPLKPNQVVANRVVGEVEGRVCLIVDDMIDTGGTICKAADILKESGAADVIVASTHALLSDPATERLKNSPISEVVVTNTLPLPPEKQLDKLTVLSIAPLLARAIREVFDDGSVTTLFGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F399</accession>
    <name>F4F399_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731494.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08525"/>
    <dbReference type="EnsemblBacteria" id="AEB42823">
        <property type="protein sequence ID" value="AEB42823"/>
        <property type="gene ID" value="VAB18032_08525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08525"/>
    <dbReference type="eggNOG" id="COG1218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071517_0_0_11"/>
    <dbReference type="OMA" id="VCRKDLA"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="27880" checksum="A1EEB58D643D743E" modified="2011-06-28" version="1">MVDGEFARWLAARAGEALVGLRAELGFDDPAALKAAGDKVSHDLIRAELARWRPGDAVLSEEDEGSRQASAAQGEAGVGSRLTADRVWIIDPLDGTREFSEQGRTDWAVHVALWARDASASHGLVAGAVGLPAQQRVLATDQPPAYPSVSVGGAGRLRLAASRSRPPAFLTDLAEEVGAQLVPMGSAGAKIAAVVTGEVDAYIHAGGQYEWDSAAPVAVATATGLHASRIDGSALKYNEADPRLPDLLVCREDLASRLLAALRRHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3B3</accession>
    <name>F4F3B3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_08595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08595"/>
    <dbReference type="EnsemblBacteria" id="AEB42837">
        <property type="protein sequence ID" value="AEB42837"/>
        <property type="gene ID" value="VAB18032_08595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08595"/>
    <dbReference type="eggNOG" id="COG3833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="AWLLKGY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="284" mass="31268" checksum="91D21004603594F0" modified="2011-06-28" version="1">MSKVTRRGHRRRSPAMSVLLHGTLILASLIAIGPIVWVLLSSLKPGYAIQSSELTLFRDTTLANYRYVLTETNFPRWFLNSVIVAAFTMTIGIFLSATTGYAVSRFNFPGRRPLMMVFLITQMFPVAILIVPIYTILARLGLINTMPALIVAYLTIAVPFCAWMLKGYFDSIPTSLDEAAALDGCGPFAIFWRVVLPLARPAVAVTAFYTFLTAWGEVAYASAFIQTDNKFTLAYGLQQFVPQFNPQWEYLTAAAVLVTIPAGLVFFFAQKHLVSGLTAGGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3C1</accession>
    <name>F4F3C1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731516.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08635"/>
    <dbReference type="EnsemblBacteria" id="AEB42845">
        <property type="protein sequence ID" value="AEB42845"/>
        <property type="gene ID" value="VAB18032_08635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08635"/>
    <dbReference type="eggNOG" id="ENOG50336PU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224319_0_0_11"/>
    <dbReference type="OMA" id="KGDHRSF"/>
    <dbReference type="OrthoDB" id="1700639at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025368">
        <property type="entry name" value="DUF4272"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14094">
        <property type="entry name" value="DUF4272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="25426" checksum="65914ACA00B26E10" modified="2011-06-28" version="1">MIVPAPDPREVREASLEELARLRLPLPPPQFPLVWEPGDRIELRPTAEIEARIAVLHLILARCFGMPPQAAMSWLLASHLVEMVTPPEFQFVTGAKGDHRSFVLHHDALFSLAWVLGLTKQLDPTMAVDERLVERLPNIAEGETFPQWRSRILAAPQHPADAAALLDLHYCLDWAYLEVDRSGGRLPGLVDANAIGQRRWALEWAVILRGPYHDEPPGWEEVDLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3D9</accession>
    <name>F4F3D9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731534.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08725"/>
    <dbReference type="EnsemblBacteria" id="AEB42863">
        <property type="protein sequence ID" value="AEB42863"/>
        <property type="gene ID" value="VAB18032_08725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08725"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926794_0_0_11"/>
    <dbReference type="OMA" id="AGPYFNL"/>
    <dbReference type="OrthoDB" id="1452155at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="33"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="28845" checksum="7F362E6CB60B988B" modified="2011-06-28" version="1">MSERVAVRKTYKLFIGGKFPRSESGRSYLVQSANVSLASRKDARDAVVAARSAVKGWAGATAYNRGQILYRIAEMLEGRRDQFVALGVPADEVDAATDRWVWYAGWSDKLPQVYGGANPVAGPYFNLSAPEPTGVVAVVAPETPALLGLVSVIAPAIVTGNTVVVAASPAAPLAAVTLAEVLATSDLPGGVVNILTGRLSETVPTLAAHMDVNAIDLTGVTDAELAAELEVKAAENLKRVLRPVPVDHDWSADPGLGRMTTLLETKTVWHPKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3E6</accession>
    <name>F4F3E6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731541.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08760"/>
    <dbReference type="EnsemblBacteria" id="AEB42870">
        <property type="protein sequence ID" value="AEB42870"/>
        <property type="gene ID" value="VAB18032_08760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08760"/>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_11"/>
    <dbReference type="OMA" id="LPRWNTI"/>
    <dbReference type="OrthoDB" id="154460at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="8"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="527" mass="57486" checksum="0C906A9DEEB512D6" modified="2011-06-28" version="1">MSERRLSESGFPIKDVYTAEDVPGDLDAQLGSPGEYPYTRGVYPTMYTSRPWTMRQYAGFGTATESNARYHQLLRAGTMGLSVAFDLPTQMGYDSDDPIASGEVGKVGVAIDSIEDMRLLFDGIPLDQVSTSMTINAPGSVLLLLYQLVAEENGVPGAALNGTIQNDILKEYIARGTYIFPPKPSLRLVADTFGYCRAEVPKWNTISISGYHMAEAGASPVQEIAFTLANGVEYVRAAIAAGLAVDDFAPRLSFFFVARTTLLEEVAKFRAARRIWARLMRDEFGAKNPKSMMLRFHTQTAGVQLTAQQPEVNLVRVAVQGLGAVLGGTQSLHTNSFDEAIALPTEKAARLALRTQQVLAYETDLTATVDPFAGSYVVEAMTSEIEAAADALMARVFEHGSAVEAIEAGFQKREIEQSAYRIAQEIDSAERVVVGLNRFAIDAEEPYEPLRVDPTIEAAQAERLAKLRAERDGAAVQRALADLREAATGSANVLYPMKEALRLRATVGEVCGALREVWGLYRPTDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3I7</accession>
    <name>F4F3I7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligosaccharide biosynthesis Alg14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_14915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14915"/>
    <dbReference type="EnsemblBacteria" id="AEB44095">
        <property type="protein sequence ID" value="AEB44095"/>
        <property type="gene ID" value="VAB18032_14915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14915"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064541_3_0_11"/>
    <dbReference type="OMA" id="VYDRIDT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="17092" checksum="AF6F1F2B1548F294" modified="2011-06-28" version="1">MGQQLLLVGSSGGHLAQLLALKPWYETWQRCWVTFDTPEAVSLLAGEDLIPAYHPTTRNVRNLLRNALLAARVLRRRRIAAVVTTGAGVALPFVVLARLRRIPTVYIEVYDRIDTPTLTARLCRPFLSKMLVQWDEQRRQYPEATVVGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Q3</accession>
    <name>F4F3Q3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21270"/>
    <dbReference type="EnsemblBacteria" id="AEB45354">
        <property type="protein sequence ID" value="AEB45354"/>
        <property type="gene ID" value="VAB18032_21270"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21270"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032306_1_0_11"/>
    <dbReference type="OMA" id="WCRIDIR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="333" mass="35730" checksum="6CD9C314183BD80A" modified="2011-06-28" version="1">MSDVAQSRYPPRRAAGRGPGWYRGDLHVHSLLSQGADLTPAHLAAAARTLGLDFIATTEHNTAAGHGEWGPYAGDDLLVILGQEVTTRTGHWLALGLAPEQAVEWRYGVRDDVVGQHLDQVRRSGGLCVAAHPHAPYPSGTLMYPYDWFDAVEVWNGRWASDLPWNADNEAALAEWGRSLAHDVHRGRWQPAIGNSDAHLAGQLGTPHTVVHAEELSCDAVLAGVRAGRSWIAESPAVTLDVTATAADRTGGVGEHLATDGEPIVVRVQVCGVPSGTITLHTEHGVVHRHSLPDDGAGVTQWRTTADETSFVRVEVRHPGRQMGALSNPIILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3T5</accession>
    <name>F4F3T5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21430"/>
    <dbReference type="EnsemblBacteria" id="AEB45386">
        <property type="protein sequence ID" value="AEB45386"/>
        <property type="gene ID" value="VAB18032_21430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21430"/>
    <dbReference type="eggNOG" id="COG5542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036370_3_1_11"/>
    <dbReference type="OMA" id="THPDEST"/>
    <dbReference type="OrthoDB" id="1421967at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="424" mass="46960" checksum="4875A316623B8673" modified="2011-06-28" version="1">MVGTGRVGRALARVPAPWPYVLAVFLGTKIVFTLVGVLTLAAFDGTEWAPPPDEAQMRQQQREVSPHGWLSLWFAWDSFLYHHLARLPLDEPWTDFAFPLLYPFLARPLAPLLGGDTALALLVIANVAFVGVLYYGVRLGERLLTDDRGPATDRADGPDAATSRIGGSGAAGGSGDGGRAARRFVRYLVLLPTAFLFHAALTESLFLCLTLATFYYAEKRRWLLVGVIGFFLALSRSAGFFVALPLVLVLLRQGGYRLRPRALWGYLRAGWPLLLLPAGWLSFMAFCWWQSGDWFAYKHAQEQGWNIRVQNPLGVLWHGLTGAAPDAVRVWIAVLFLAVLVAGARRLGLPYLVYGVMMVLVPLSMGTPVYKSLLRYLLAVFPVALVLAGWARRPQLDVWLTAVLAVLQGALFVIWLAYWTHFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F435</accession>
    <name>F4F435_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28041"/>
    <dbReference type="EnsemblBacteria" id="AEB46681">
        <property type="protein sequence ID" value="AEB46681"/>
        <property type="gene ID" value="VAB18032_28041"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28041"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_0_11"/>
    <dbReference type="OMA" id="QVEFAGY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309082" description="AP_endonuc_2 domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="76"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="354" mass="38336" checksum="9AE8E428393C57E9" modified="2011-06-28" version="1">MSRRRILGAFAGVAGAAAAGAAGFGSAAVANSKGNGNGVLVPPGKRGIILYSVRDRISAAPDTSGVPYGFERVLGRLAEIGYKEVEFAGYTQHTSILGRQITPTEIRKILDDNGLRANGSHASIPSTVTPNTIAAFEQTLDTAEILGMQHIGTGSDPTSSNYKADWDAAADRWNLFGEMARARGLKLYTHNHDAAYNFLLDSGPLDGLGRPTRSSGIRKLEYFFDKTEADRVFFEMDIYWAHVAQHRFRAYTDPDGNLQTDVFDPLATVATRTMRFPLFHAKDGAFNPNVAAGYEMVPLGQGDIDYGNFFANMGAKGYHNPMWEQDNAPGGAADPGRSLRYAEVSYQHMSGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F454</accession>
    <name>F4F454_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_03925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736499.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03925"/>
    <dbReference type="EnsemblBacteria" id="AEB47867">
        <property type="protein sequence ID" value="AEB47867"/>
        <property type="gene ID" value="VAB18032_03925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03925"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1633653_0_0_11"/>
    <dbReference type="OMA" id="AGKHTEF"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="149" mass="16986" checksum="02B520F750AE3B2B" modified="2011-06-28" version="1">MSVEPLRCAGALIVDPEGRLFFQRRSPDRRLFPNCWDIVGGHLEPGETVEEALRREVLEETGWRVAEILGPVGEFRYVGDDGLTRIEYDWLVRVDGDLAAPVLEAGKHTEYRWLGPDDVDVLDEHRHVNEGLIRQIAERAFALLRSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F474</accession>
    <name>F4F474_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell envelope-related transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04025"/>
    <dbReference type="EnsemblBacteria" id="AEB47887">
        <property type="protein sequence ID" value="AEB47887"/>
        <property type="gene ID" value="VAB18032_04025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04025"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_0_2_11"/>
    <dbReference type="OMA" id="METIMLP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="74"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="325" mass="35413" checksum="06168E97BEBC7FA7" modified="2011-06-28" version="1">MVAGVVVLALALIGGGGAWFYARSLDKNLARTDPFSEITGGRPAKSVDGALNILMVGTDSRDPDAPMDRPGEWRADTIIVMHIPADHQKAYLVSIPRDLYVPIPESAGADCGSGQRRKINAAFAFGGLPLAVRTVECFTDVHIDHVMAIDFGGFKQVTDALGGVDLEVERTITSIHKPYRKFTKGTNHMNGTEALDWIRQRKQFPDGDFARMRHQQEFLRALMDKAASTGTLTNPKKLNAFLRSVTDAVTVDHGFSLTDMAVQFRNLRGENLTFVTSPHLGSETINGESVVVSDREKALAMYRAMSADTMAEWMSANKPSTSGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F488</accession>
    <name>F4F488_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04095"/>
    <dbReference type="EnsemblBacteria" id="AEB47901">
        <property type="protein sequence ID" value="AEB47901"/>
        <property type="gene ID" value="VAB18032_04095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04095"/>
    <dbReference type="eggNOG" id="COG3824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123836_1_0_11"/>
    <dbReference type="OMA" id="GEWYAGV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="116" mass="13146" checksum="11EF20DD69B0F6DB" modified="2011-06-28" version="1">MAVEMERERFEELVGEALDEVPEELLALMSNVVILVEDDPPPGEDLLGLYEGHALTDRGWDYAGVLPDRILIYRNPILRICETEDDVVEEVAVTVVHEIAHHFGIDDERLHDLGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4C4</accession>
    <name>F4F4C4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_04275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04275"/>
    <dbReference type="EnsemblBacteria" id="AEB47937">
        <property type="protein sequence ID" value="AEB47937"/>
        <property type="gene ID" value="VAB18032_04275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04275"/>
    <dbReference type="eggNOG" id="ENOG5031JHI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041277_0_0_11"/>
    <dbReference type="OMA" id="WAATRRS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="439" mass="46012" checksum="759597509F6ADA37" modified="2011-06-28" version="1">MSNADATAPRPAWWHRLDATGGGLGLDLGIYAGSAAFATITAATSTLVTHRHWGSLAAVGYLAAALLVTGQLLIRRRRPDSALSGVPARWLVASLTWSTVTLLPLTWQSIQRAAGRTDRAQEEVLVVEDSGRRLLETGTPYLGPDAIAALPAGEQLLGYTPYQPGMALFGLPRAVHDSWWTDARVWFAVGTALALVLAARLLRPTPGLPARNRATLLRGMQAATVLPVCALTLATGGDDLPVLALCLLALACAGTARPGWAGIAVGVAGALKLFAWPVAMVLVIWGFTRRAGLRVAAGAFGIPALALLPVLLVDHEALVENVLRFPLGHGLVASPAQSPFPGYLIAANLPAGRAVAAALLVAAGLAIAVRLARRPPRTARTISLICAYGLLAAILLMPTTRFGYLLYPIAFLVWAPALDLPRIGQPAGEEARQGVHLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4F1</accession>
    <name>F4F4F1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gtra family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_08955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731580.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08955"/>
    <dbReference type="EnsemblBacteria" id="AEB42909">
        <property type="protein sequence ID" value="AEB42909"/>
        <property type="gene ID" value="VAB18032_08955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08955"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1199086_0_0_11"/>
    <dbReference type="OMA" id="SYLMNRH"/>
    <dbReference type="OrthoDB" id="1813832at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="239" mass="26492" checksum="CE2038AE0991F06A" modified="2011-06-28" version="1">MPLVRLLPERWQKFIHEALKFGLVGGINTVINYAVFNALALTIFVDGQLKATVIATVVATITSYLMNRHWTYRDRPKSAMQREYALFFLFNGAGLLIELGVLAAAKYGLGMTSLLALNVAKTGGVVLATLFRFWSYRTFVFQPAAPAEAKPAWQGLPRDEWDTMAGMDPVAELAESVTELEEEEPPATRPPSLTPRPLQPRAAALSNEAELTAALDKELEAELAAELQPAPAHRRFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4J7</accession>
    <name>F4F4J7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731626.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09185"/>
    <dbReference type="EnsemblBacteria" id="AEB42955">
        <property type="protein sequence ID" value="AEB42955"/>
        <property type="gene ID" value="VAB18032_09185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09185"/>
    <dbReference type="eggNOG" id="COG1507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097805_1_0_11"/>
    <dbReference type="OMA" id="IAHRCPC"/>
    <dbReference type="OrthoDB" id="1922611at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="19518" checksum="8D216AD971869373" modified="2011-06-28" version="1">MTVVPPPEPAAASVPPPEREPATDADLAAVAAQLGRPPRGTRAVAHRCPCGLPDVVETTPRLADGTPFPTLYYLTCPRATAACSRLESAGLMREMADRLATDPELAARYRAAHEDYLARRDAIAEVPEIAGISAGGMPGRVKCLHVHLGHALGAGPGVNPFGDETLDLVEPWWTAGRCVDVPESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4U9</accession>
    <name>F4F4U9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734091.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21690"/>
    <dbReference type="EnsemblBacteria" id="AEB45438">
        <property type="protein sequence ID" value="AEB45438"/>
        <property type="gene ID" value="VAB18032_21690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21690"/>
    <dbReference type="eggNOG" id="COG3806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061391_0_0_11"/>
    <dbReference type="OMA" id="RADPAWE"/>
    <dbReference type="OrthoDB" id="1789233at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="27924" checksum="6BBD0CFB80388E0C" modified="2011-06-28" version="1">MNTHPSLTQIDGYAAGDPGLDEAEVWAVEVHLEDCADCRARLAASTTADARSLIDRVAMNLDRELALSPVPAGRIRSWSVLRQRWFVGTLLPWLAMTAAVLACAVLLGELWVGMPSLVLLIAPLAPLPGVAVAWHRRADPAWELIAATPAAGLTTLLRRTAGVLAFVIPALAVAGARTGVSLALMLAPCLAFTAATLLLGTLIGVRRAALGLVAAWTIVVIAPSLAIARIPAVLAMESAGIWAAAAVVLTVAAFFRADGFRRLSQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Z7</accession>
    <name>F4F4Z7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21930"/>
    <dbReference type="EnsemblBacteria" id="AEB45486">
        <property type="protein sequence ID" value="AEB45486"/>
        <property type="gene ID" value="VAB18032_21930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21930"/>
    <dbReference type="HOGENOM" id="CLU_042795_1_0_11"/>
    <dbReference type="OMA" id="TMPDWGR"/>
    <dbReference type="OrthoDB" id="1513329at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="44022" checksum="B9929A3A1A17DEC5" modified="2011-06-28" version="1">MAAVVAAVALIVKLWALHRDPGNRTILAKAGICLGCGIAVTAGWAPVHSLIDRVSGVANLAKPIEHGSALIAATAIQFLFLHLGDPEKARRLMPRRLVFLGAVLAVMIAMFHAADFPESEPLHFAERYGDMPQVSIYMLAFLLYLGVTVVDILRMSLGYARYAGTRLKIIMGLLSAGAAFGAAFVAHKALFLGLKLADLAPPWPEPVVTQTLVTFSVVLICSSFVLATLWKAVDGVRAWPRRSAMYRDLHALWYLLYQAVPDIVLVTPRRPKRDPWWVFGVEQRLYRRCVEIGDGIQALGPQDAQVRTVASGRAAELGWDQARAAAAGEAAAILVAVRRLEQGRVVRREVEPDLEPQPAKVARVDVEADARRLALISISLSEPLVRETVARFASEPASGERARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F550</accession>
    <name>F4F550_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recO</name>
        <name evidence="11" type="ordered locus">VAB18032_28306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735382.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28306"/>
    <dbReference type="EnsemblBacteria" id="AEB46732">
        <property type="protein sequence ID" value="AEB46732"/>
        <property type="gene ID" value="VAB18032_28306"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28306"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066632_1_1_11"/>
    <dbReference type="OMA" id="LCTQSET"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="10">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="270" mass="29050" checksum="523229A56AC436DE" modified="2011-06-28" version="1">MAGYRRQLYRDDAVVLRVQKLGESDRIVTLLTRRHGRLRAVARGVRRTTSKFGARLEPFGHVDLQLAGDPKGELGSSLHTVSQVEGIDLYGKRFLGDYPRYTAASAIAETAERLTPVEREPSLRLFQLTLGALRALAQGEHAITLVLDAYLLRGMALAGWAPALTACAVCGTPGRHRAFSVPAGGAVCPDCRPPGAAHPAPATIDLMSALVGGDWRVANATDTGVRRECSGLVAAHLQWHLERTLRSLPLVDRGGPATTAVPEREQGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5D0</accession>
    <name>F4F5D0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736609.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04480"/>
    <dbReference type="EnsemblBacteria" id="AEB47978">
        <property type="protein sequence ID" value="AEB47978"/>
        <property type="gene ID" value="VAB18032_04480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04480"/>
    <dbReference type="eggNOG" id="COG1023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_0_0_11"/>
    <dbReference type="OMA" id="NGYALMY"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="159"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="31328" checksum="9509D050AB08F39D" modified="2011-06-28" version="1">MQLGLVGLGRMGGNMRERLRAAGHEVVGLDHNAELSDVANASELAEKLAAPRAVWVMVPAAVTDATIDELAEVLGEGDIIIDGGNSRFSDDAPRAERLNERGIGYVDVGVSGGVWGRQNGYGLMVGGSQEHVDRLMPIFEALKPEGDFGFVHAGPVGAGHYAKMVHNGIEYGLMHAYAEGYELMTASELVTNVPGVIKSWREGTVVRSWLLDLLDRALDEDPELAQLTDYTEDTGEGRWTVDEAVRLAVPLHVITASLYARFASRQDESPALKAVSALRQQFGGHAVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5D7</accession>
    <name>F4F5D7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09255"/>
    <dbReference type="EnsemblBacteria" id="AEB42969">
        <property type="protein sequence ID" value="AEB42969"/>
        <property type="gene ID" value="VAB18032_09255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09255"/>
    <dbReference type="eggNOG" id="ENOG5033ATF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444830_0_0_11"/>
    <dbReference type="OMA" id="GPRRIWP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="188" mass="19724" checksum="69C47E4AD00A738C" modified="2011-06-28" version="1">MIGNLTGRVRGLQTVASRVALAPVLIRLGIFVSSLAGLLLAYPAEVVAGQALPALLGVAALPALAPRRFWPTFAALVTVGGWLMATDGYDRPVALWRLTAVAVLLYLTHTLCALVAVLPYDAVVDPDLIVRWLTRTGGVLLATAVLGVLLLELGRLGAGTAGWQFVTIAGLLVALAVTATLAWLLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5M7</accession>
    <name>F4F5M7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_15640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732904.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15640"/>
    <dbReference type="EnsemblBacteria" id="AEB44240">
        <property type="protein sequence ID" value="AEB44240"/>
        <property type="gene ID" value="VAB18032_15640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15640"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040172_0_0_11"/>
    <dbReference type="OMA" id="FLIRQQC"/>
    <dbReference type="OrthoDB" id="1375732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307433" evidence="3">
        <location>
            <begin position="35"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="483" mass="47210" checksum="B23540CDF5DFC263" modified="2011-06-28" version="1">MPTSPLRRVGAGLGVAVATALAIVVATPPSGVAASSAAHSAAARDAAAWLAGEYADGVLPGPFGGADWGLTIDGMLALAATGVDPSTRQAATAQIAANVRSYNSYDDWGIEGFTDGGATAKLLYAASAAGTDPTDFGGWDLRAETLALVSGAHTGHQHGRITSRTTDESGQDPSNTFDQSFAVLGLARSGGAPQETVDFLVRQQCAAGGFRLYPDAAGAPSPSCDAESNATLDVDSTAMAVQALLAAGADDAAGRGADWLVAQQRADGSFGGSGPTSGANSNSTGLAGQALAAAGRDTEATRAAQALAALQLTGANGGAATADAGAIAYDTGALTEAVDEGITDNLRDQWRRATAQALLGLAQVPLGRIGLDPPPTGGPTPSTSASPTPTGSPAPSASPTPTDAPTASPTPSASPSDTPTAGPTPSDTPSTPVATPTVSTSPVAGGPGRLPTTGVAIGGYVLTALLLVGGGAVLLVLGRRRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F653</accession>
    <name>F4F653_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28671"/>
    <dbReference type="EnsemblBacteria" id="AEB46805">
        <property type="protein sequence ID" value="AEB46805"/>
        <property type="gene ID" value="VAB18032_28671"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28671"/>
    <dbReference type="HOGENOM" id="CLU_2995429_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="57" mass="6699" checksum="8C21DE4EB04319A8" modified="2011-06-28" version="1">MWRVEHVPYPTRGMNRLRPGMQRPSWWSDDLPVAMPATGSVGRVGKTRRPARRRDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6E6</accession>
    <name>F4F6E6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_09870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09870"/>
    <dbReference type="EnsemblBacteria" id="AEB43092">
        <property type="protein sequence ID" value="AEB43092"/>
        <property type="gene ID" value="VAB18032_09870"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09870"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_9_11"/>
    <dbReference type="OMA" id="WVLASHQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="450" mass="46999" checksum="F7CE2FC90FB2206E" modified="2011-06-28" version="1">MAFRPLVRPARWPQTLLVSRPVRLHPAWIVAAVAFVALVGAAGFRATPSVLLHPLHAEFRWPLATISAAVSVNLLLYGLTAPFAAALMDRFGIRRVVAAALTMVAAGSGLTVFMTASWQLIACWGVLVGLGTGSMALAFVATVTGRWFVHRRGLVTGVLTAGGAAGQLVFLPLLAMLVGAYGWRSAALVVAGAALLVVPLVLRLLREYPADLGLPPYGASEIVEPVRPTGGAAARALGALAQAARTRPFWLLAAGFAICGATTNGLVGTHFIPAAHDHGMPQTTAAGLLALVGLFDIVGTIASGWLTDRYDPRLLLGAYYALRGGSLLVLPGLFAATTEPSMLVFVIFYGLDWVATVPPTVALCREYFGLSGAVVFGWVFAAHQFGAAVAAIGAGLVRDELGTYTLAWHVAGALSVGAAVLSLMLLRRRGAVLMEPAPVAVAPKAWSYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6F4</accession>
    <name>F4F6F4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731771.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09910"/>
    <dbReference type="EnsemblBacteria" id="AEB43100">
        <property type="protein sequence ID" value="AEB43100"/>
        <property type="gene ID" value="VAB18032_09910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09910"/>
    <dbReference type="eggNOG" id="ENOG502Z9GY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543818_0_0_11"/>
    <dbReference type="OMA" id="GRSMRFR"/>
    <dbReference type="OrthoDB" id="1419476at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="508" mass="53934" checksum="268F0F17B67D2EAA" modified="2011-06-28" version="1">MSTLRALAAAQAVAAGMAQPVATVRHLHLSRRPLVLVPLAMAGEANAPLAAMVGAAPGEARLLIVPQPRNRDQRFAFVAELAATVLPYVDAHRGANEAVPVDRGRDVRYRYLDAPQLLVPNPAGVTFLRLLGRATRFRRVDGDHPVPPQVPLLGRWLTFFAERAEHPGSSALVAMTQALSLHWATGQSAVEDLHLPALLGWIAPPAGRSGVEAAAWAEDPVRCPPAGPATDPSFDNERLAPAIEAYAAAESDEVARGEAYAELEKLLRDQLTPTWELMWRGVGLLRALPPGARVAARWDGDRDAFTAYADHVDADGAPQPRRDGAVAAAARLHRLERAADLYAVQRAYDDPLVMAEYRLTGEAFVGEVVLADAARIDDSGRRPVLRPRIQLVTTDPVLVPVGAVLSSPNRPAQKARVVFVTPVADGKTEVVVELSGGMGRGLTAAPGSVPEVGERLCYTTLSEAYVPAGGFPAVEDTPWTHGGPPAAAPVDPLPIGEGAAPVPDEDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6I6</accession>
    <name>F4F6I6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732976.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16020"/>
    <dbReference type="EnsemblBacteria" id="AEB44314">
        <property type="protein sequence ID" value="AEB44314"/>
        <property type="gene ID" value="VAB18032_16020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16020"/>
    <dbReference type="eggNOG" id="ENOG5032XQ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633049_0_0_11"/>
    <dbReference type="OMA" id="HICSATH"/>
    <dbReference type="OrthoDB" id="1675221at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="433" mass="48753" checksum="A20257ED040074BB" modified="2011-06-28" version="1">MNLGTLMACATCGYSLTTHRHGDQIHYRHPVSETDRHPPVPVPAHLIDDVYDRCHICSATHPVWNYRTAELEAQGLGGTREVIQTYNTHWHVCLRCAQHIEADDPDTLTAASAALMGWHPHDPRHTILGMVHRAIVLTREGRTLITTTDWPPATITPDMLPKIRDRLTRLLRSPADLPDPLNTRTTRHTLADDLDRAPLYWINPEFTRLTHDVTGNQPPAPVTDRITPTRSGLLAWPHPIGQHHQIAAVSWTPHTDGWHLLAYRSIGAGLTNDLMPTLRHDIGWLIPTHTEHLPAGTTIDGHHPLGPLITTWLLMNQHMADAVPAKLPKTITKAYQRQQRPTPDVRLVRITPPTTTPPTEPNPNSQKRSRAQPDYRYWVSGHERNQAHGPGRRLRKTITIEPFLKGPEDKPIKLSTTVRILGTRQPPNTTTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6M5</accession>
    <name>F4F6M5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44353">
        <property type="protein sequence ID" value="AEB44353"/>
        <property type="gene ID" value="VAB18032_16235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16235"/>
    <dbReference type="HOGENOM" id="CLU_149294_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="97" mass="10841" checksum="21396FCF03525A16" modified="2011-06-28" version="1">MWVPTDVKICNATTGDSLPTPSWSSWQLKTTDDYQLQPADITPEPRQPALPYSATILPNDCVRGWLTFEIDKGSRIKEIRLIEDQLFGPGPAIAIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6T3</accession>
    <name>F4F6T3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="4" type="ordered locus">VAB18032_22540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734260.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22540"/>
    <dbReference type="EnsemblBacteria" id="AEB45608">
        <property type="protein sequence ID" value="AEB45608"/>
        <property type="gene ID" value="VAB18032_22540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22540"/>
    <dbReference type="eggNOG" id="COG0830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049215_3_0_11"/>
    <dbReference type="OMA" id="HCVAYET"/>
    <dbReference type="OrthoDB" id="1942614at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="234" mass="23819" checksum="48FD3252C78DAD72" modified="2011-06-28" version="1">MAATTIALLVADGRFPAGAHAHSSGLEAAVAAGRVTDLATLDEYLRGRLTTAGLVAAAFAAAARQAAGLPPRSDGVHDRRLTLAQLDAELDARTASPAQRAVSRRQGRALLRAGREIWPAATFDDLPATPGGPHQPLALGLVGAAAGLDAAQVATVAVHATVTGSASAAVRLLGLDPYQVQALLVRLADACDATATRAARAAELPPRRLPAAAAPLADIHAEAHATWEVRLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F702</accession>
    <name>F4F702_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28976"/>
    <dbReference type="EnsemblBacteria" id="AEB46866">
        <property type="protein sequence ID" value="AEB46866"/>
        <property type="gene ID" value="VAB18032_28976"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28976"/>
    <dbReference type="HOGENOM" id="CLU_3031192_0_0_11"/>
    <dbReference type="OMA" id="CGNRISV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="5787" checksum="CD4ADEBC64BF8AD9" modified="2011-06-28" version="1">MASISIGSAGRVTSGGKQLWCPACGNETNWRDITATNQRTQATCGDCGNRISVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F791</accession>
    <name>F4F791_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10155"/>
    <dbReference type="EnsemblBacteria" id="AEB43149">
        <property type="protein sequence ID" value="AEB43149"/>
        <property type="gene ID" value="VAB18032_10155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10155"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_976243_0_0_11"/>
    <dbReference type="OMA" id="RNSAWLL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="28753" checksum="564F2F6504643720" modified="2011-06-28" version="1">MHSWWLLLPILGLSCLGGFGFLYVGLRARRPAWWIAGIGYLLIGWTAFVLTGETDSESALSDWMAGLVLAVWAASIVHAFLINSSWLKWRAGHRPWYAEQPPGGPGSPYPPGPLAPPPSLSPTAPEYPSTPPISPAYPSEAPTMPVYPAGDPTFAAYPPLPQPTDYFGPGPAAGPVPDQRVDAGPQAANTGPVEVNSAGPHDLAALPGFDPQRARQVLAERDRRGGFGSLSEFVAAAGLAPHEYARLRDRLVCAPPAPPAPGLPPQGRVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7F2</accession>
    <name>F4F7F2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-deoxyerythronolide-B synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Type 1 polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">abyB3</name>
        <name evidence="8" type="ordered locus">VAB18032_16425</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733051.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="SMR" id="F4F7F2"/>
    <dbReference type="STRING" id="263358.VAB18032_16425"/>
    <dbReference type="EnsemblBacteria" id="AEB44391">
        <property type="protein sequence ID" value="AEB44391"/>
        <property type="gene ID" value="VAB18032_16425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16425"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_16_6_11"/>
    <dbReference type="OMA" id="EYATARL"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="913"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="888"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="890"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEK75504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="992" mass="104667" checksum="02219101B8D12ECF" modified="2011-06-28" version="1">MSETREEKLVEYLKWVTGELQETKAQLARARAEREPIAIVSAACRLPGDVHSPEDLWRVVVDGVDAIGDVPTDRGWAVHEVYADAPAHRPLGGFLSDAAGFDAAFFGIGPHEATAMDPQHRLLLESSWEAVERAGIDPTTLRGSATGVYAGLVSQNYAAYGTPPELNGHLMTGTATSVASGRIAYLLGLRGPAVTLDTACSSSLVALHLAAQALRRGECDLALAGGATVMATPALLAEFVTQGGLSPDARCKAFAAAADGTGFAEGVGVLVLERLADARRHHRRVLAVLRGSAVNQDGASNGLTAPSGPAQEEVIRAALADAGLRPSDVDHVEAHGTGTRLGDPIEAAALLATYGQDRAEPLWLGSVKSNIGHTQTAAGVAGVIKVIEALRHERLPRTLHVDEPTPHVDWAAGKVRLLTEEQPWPRGKRRRVAGVSSFGISGTNAHVLIEEGDPEPPPTPPTPSAHPVAWLLGAKTDSALRAQAARLRQRFAVASHDPLDVAVALATTRTAFDRRAAVVAADHDGLLRGLDALAAGETTPGRAVRGPTAFLFSGQGSQRVGMGTELRRVFPAFRDAWREVADEVDRHLDQPLDRVLADEDLLLRTEYAQPALFTLEVALVRLLGGWGLRPDLLLGHSLGELVAAHVAGVLDLPDAVALVAARGAAMQAAPAEGAMVAIRAAADEVRASLAGREHEVSVAAVNGPRSTVVSGDAGAVQEVAAHWAATGHRTSRLRVSHAFHSPHLDGVLDGFRAVAAGVRHHPPSIPVVSNLTGTVVEAFTAEHWVRHVRQEVRFAAGVSALTSAGVRRFVEVGPDAVLAALAGENAPGTPVVATLRRDESEALTVVRALAASHVTGARVDWRAFHDERTAAVPLPTYPFEHRRYWVSPPTGPAPTAPPPVADEPPRESTPHEERLLDLVRTHAAAVLGHDTPESVGPDDNFVEIGLSSFTALEVRNRLCEGTGLELSPLALFEHPTPAALAEHLRAVRAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7V5</accession>
    <name>F4F7V5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734394.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45742">
        <property type="protein sequence ID" value="AEB45742"/>
        <property type="gene ID" value="VAB18032_23220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23220"/>
    <dbReference type="eggNOG" id="ENOG5034B4P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741756_0_0_11"/>
    <dbReference type="OrthoDB" id="1913346at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313665" evidence="2">
        <location>
            <begin position="28"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="373" mass="38457" checksum="64425BDF96F1A570" modified="2011-06-28" version="1">MSLSRPAVAFTALALLIGLGHPLPAAATQPASAVPGGQPASALPGSRPASAGLGGQHVAAGKPGTAGTGEVRTVVRDAVTGAAARACLNLVPADRDPLTVVGLGEVQQGRSGGCSDLDGGPVVSTDVAPGRYHLLARPYDSARYGAQWVGPHGGTGQRERAAIIHVRPGRVVTTPRVRLDPPGTVTGRVTRVADGTPVSAAAVLLLPEIQHPKYGSQGVLTDDDGRYTMTGLGPYRWPLYFSGYGLASQWSGATADRLRATTVRVRAGATVTADTALTAGTVVSGTITTAEMPFYSQVVAFHARTGEVVGVADAAENYLLRLLPGQRVLLRCDCVYTPSRWYPNAAGIDDARTLRVRNAPVTAHFDLTGPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8J4</accession>
    <name>F4F8J4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_17175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17175"/>
    <dbReference type="EnsemblBacteria" id="AEB44539">
        <property type="protein sequence ID" value="AEB44539"/>
        <property type="gene ID" value="VAB18032_17175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17175"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="OMA" id="GVKPAGH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="274"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB44539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="437" mass="46921" checksum="9D7CB46C89FE4E2A" modified="2011-06-28" version="1">MGGYGVQIALVLVLVLVNAVFAGSEMALVSLRESQLQRLERTSRAGRVLARLARDPNRFLATIQIGITLAGFLASAAAAVSLAAPLVGPLGFLGSAAEPVAIVLVTIVLTFVTLVLGELAPKRIAMQRAQGWALLVARPLDALSAFSRPVVWLLGKASDAVVRLTGGDPRARRQEVTTEELRDIVAGQRNLTPEHRMIISGAFEVAERILREILVPRREVVTLSESLTAPQALRELGRSGQTRAPVVGRAGLDDTVGVVHMRDLLDQEGPVAEHVSVPLYLPETLKVTEAIREMRSQRQQFALVVNERGAIDGIVTMEDLVEEIVGEIYDETDRDVQALVREADGSLLLSGGFPLHDLPDVGVDLDEDTLEPGDYTTVAGLVLAHLGHIPKTPGEVVELPGLTAEVAEVTGRAITRVRLRTTARPDGPDTDEPEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8N3</accession>
    <name>F4F8N3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_23390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23390"/>
    <dbReference type="EnsemblBacteria" id="AEB45776">
        <property type="protein sequence ID" value="AEB45776"/>
        <property type="gene ID" value="VAB18032_23390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23390"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="OMA" id="AMNRVES"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="268"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="486" mass="51410" checksum="300170D23ED75763" modified="2011-06-28" version="1">MSVLRRWVAGWSLRTRLVVTLVALLAVVSLAIGGITTAALREFLVSRLDEQLLPMAGMRAGTPWEPGPGAPSWNDVRVPRGFPPGTINARVVDGQVTEAWTLADRQERSVPVDEVAALAAVPTDGRAHTRDLGDRGSYRLVARQSTAGVVRVLGVPLSGVQETVWWMVLAQAGVTAAGLLVAGTAATVIVRATLRPLRRVAATAGRVSELRLDRGEVALSERVPTADTDPRTEVGQVGAALNRLLGHVAAALAARQASETRVRQFVADASHELRTPLAAIRGYAEVARRGHDQVPADVAHALRRVESESTRMTSLVDDLLLLARLDSGRPLAVESVDLTALVVDAVSDAHVAGPDHRWQLDLPDQVIRVPGDPARLHQVLANLLTNARVHTPPGSTVTTSLRLAGEVAELGVTDDGPGVPAELRADVFERFARGDSSRSRAHGSTGLGLAIVAAVVAAHHGSVTLDSRPGRTVFTVRLPDPTLDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8R5</accession>
    <name>F4F8R5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_23550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734460.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23550"/>
    <dbReference type="EnsemblBacteria" id="AEB45808">
        <property type="protein sequence ID" value="AEB45808"/>
        <property type="gene ID" value="VAB18032_23550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23550"/>
    <dbReference type="eggNOG" id="COG2119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040186_2_0_11"/>
    <dbReference type="OMA" id="QGKWHSF"/>
    <dbReference type="OrthoDB" id="2050363at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="20397" checksum="2CD6BE744DA20613" modified="2011-06-28" version="1">MEGFLVALAVSFGVIFVAELGDKSQLMALAFATRYRTMPILIGITVATAVVHLASVAIGYGLGSALPTGWISLLAGAAFIGFGLWTLRGDSLTEEDKRKAARGGKSAVLTVGVAFFLAELGDKTMLATITLATQYGWFGTWVGSTVGMVAADALAIIVGRLLGRKLPERTIKYGAAALFAISGIWLIIDALSELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F930</accession>
    <name>F4F930_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, luxr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_04660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730732.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04660"/>
    <dbReference type="EnsemblBacteria" id="AEB42058">
        <property type="protein sequence ID" value="AEB42058"/>
        <property type="gene ID" value="VAB18032_04660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04660"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="221" mass="23649" checksum="A3DDE51B78CD3716" modified="2011-06-28" version="1">MTSVLIVDDQDLVRAGIRTLLSADPQIDVVGEAADGRSGLRLARQYRPDVVLMDIRMPVLDGLAATAAIRADAGLAATRVLILTTFDDDEDIIEAVSLGAAGYLLKDTPSDELRRAVLTTAAGGNLLSPTVTRRVMERLAAAPRPARPDPRLAVLTERERAVLARVGLGETNDEIGRALFISPATARTYVSRLLAKLNARDRTALAVIAHRAGLSEPPDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F952</accession>
    <name>F4F952_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730754.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04770"/>
    <dbReference type="EnsemblBacteria" id="AEB42080">
        <property type="protein sequence ID" value="AEB42080"/>
        <property type="gene ID" value="VAB18032_04770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04770"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_0_11"/>
    <dbReference type="OMA" id="SRQQGWW"/>
    <dbReference type="OrthoDB" id="1060221at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="293" mass="32892" checksum="E894A0171AAD220E" modified="2011-06-28" version="1">MSERRSPTIRRRRLGAELRRQRETAGITIEAVAEQLECSASKISRIETGHTTATPRDVRDMLRIYGVVGAESDELVQIAREARQKGWWHPYSTVLVGAYVGLEAAASSIRAYEQQVVPGLLETEDYAGAMIRAARPDFTAEQVRQRVRVRLGRQSLLTQDDPVDLWVVLDEAVMSRPVGGDTVMRDQLNRLVEVAQLPNVTLQVLPFEVGAHAGMDGTFTILSFPEPGDPDVVYAENATGGLFLEKSDELQKYSFIFDHIRAAAMRPEESVGYIAKLAEEPLWKWRRKDSPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F961</accession>
    <name>F4F961_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730763.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04815"/>
    <dbReference type="EnsemblBacteria" id="AEB42089">
        <property type="protein sequence ID" value="AEB42089"/>
        <property type="gene ID" value="VAB18032_04815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04815"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025431_1_1_11"/>
    <dbReference type="OMA" id="ITQDHTW"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="475" mass="49552" checksum="7D2198E5DB85CEFE" modified="2011-06-28" version="1">MTLTLRYAAHSDRGLIRDGNQDSVYAGPRLLAVADGMGGMAAGDVASNIVIGAMAPLDEDVPGDALVDALRSAVGTANQQLRETVDANPQLEGMGTTLTATLFSGSKLGMVHIGDSRAYLLRDGDFNQITKDDTYVQMLVDEGRISPEEASSHPQRSLLTRALDGRDIDPEYSVRQVLPGDRYLICSDGLSGVVSAETIAETMREYADPQQCVERLVQLALRGGGPDNITVIIADATDRDIVEAAPIVGGAAARDRGMATSADVSTPAARASALSAPRPPVPEEPAGNDDEPEARRRPLRALAMTTALLVIIGGGVFAGYDYTQRQYYVGATDDGQVAVFRGIQGEIAGMDLSTVHSKSTAQLDDLTLAAQEQVKQGIPARNEPDAARRLAELTMDSPTNVNLKPLCPPTSSPSVDPTTESTSPPPSTPAGSASPVSSGSPSPDGSLAPPVSTPDAPPTDAFTPTVDPAACRSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F968</accession>
    <name>F4F968_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730770.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04850"/>
    <dbReference type="EnsemblBacteria" id="AEB42096">
        <property type="protein sequence ID" value="AEB42096"/>
        <property type="gene ID" value="VAB18032_04850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04850"/>
    <dbReference type="eggNOG" id="ENOG5033BI6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186178_0_0_11"/>
    <dbReference type="OMA" id="LWFVVFP"/>
    <dbReference type="OrthoDB" id="2090823at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="100" mass="10931" checksum="0C83C80038716BA1" modified="2011-06-28" version="1">MYGWIWRKLPFGLPGKLIGSLLLATTVVALLWYVVFPWAGPLLPFTGEDVQVTQQDSEVPGAPGDVEPGTDPADDEPAGDEHDLPYDTDRNNTPPPDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9D6</accession>
    <name>F4F9D6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mnmA</name>
        <name evidence="8" type="ordered locus">VAB18032_11060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11060"/>
    <dbReference type="EnsemblBacteria" id="AEB43330">
        <property type="protein sequence ID" value="AEB43330"/>
        <property type="gene ID" value="VAB18032_11060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11060"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_0_2_11"/>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="37268" checksum="52A1C323BA22A421" modified="2011-06-28" version="1">MSGGVDSAVAAARAVQAGHDVTGVHLALARNPQTYRTGARGCCTLEDSRDARRAADVLGIPFYVWDMADRFHADVVDDFVAEYAAGRTPNPCLRCNEKIKFAAVLDRAVALGFDAVVTGHHARLGPDGLLRRSVDEAKDQSYVLAVLTREQLDRSMFPLGDSTKAQVRQEAAERGLAVADKPDSHDICFIADGDTRGFLAQRLGESPGDVVDATTGAVVGQHAGAYAYTIGQRRGLHLDRPAPDGRPRYVLSITPKTNTVTVGPAEALEVSTVSATRPVWTGGARPEQPIECEVQLRAHGVVVPAVVTVDGDRLHADLRRPVRGVAAGQAIVAYRPDPAGDIVLGSATITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9E2</accession>
    <name>F4F9E2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="3" type="ordered locus">VAB18032_11090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732007.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11090"/>
    <dbReference type="EnsemblBacteria" id="AEB43336">
        <property type="protein sequence ID" value="AEB43336"/>
        <property type="gene ID" value="VAB18032_11090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11090"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_1_0_11"/>
    <dbReference type="OMA" id="VTPMAMK"/>
    <dbReference type="OrthoDB" id="1780195at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="10862" checksum="9ABBD4664C748D13" modified="2011-06-28" version="1">MAAISREEVAHLARLSRLAVTEEELDTFAGQLDVILQAVAQVGEVAAADIPPTSHSVPLTNVFREDVVTPCLTPQEALSGAPDAEEQRFRVPRILDEDVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9N5</accession>
    <name>F4F9N5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17555"/>
    <dbReference type="EnsemblBacteria" id="AEB44613">
        <property type="protein sequence ID" value="AEB44613"/>
        <property type="gene ID" value="VAB18032_17555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17555"/>
    <dbReference type="eggNOG" id="ENOG5031KBW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042647_0_0_11"/>
    <dbReference type="OMA" id="NHCRAVW"/>
    <dbReference type="OrthoDB" id="1094961at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="2">
        <location>
            <begin position="170"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="43665" checksum="C6EC8D664D297FAC" modified="2011-06-28" version="1">MRERIRAVLAGAIDYESGLDALAVTRSTEVDPELVAAKDEACARLWRGGWQPAEVHRVVARRGQPRQAELVTDAVAAHLRRFPRDAVDGRWLAQADALGAQVWWTDDATYVDELAARWRLDRVAVLDLLVGLLVILAALPPIEVLVPPPGSAPPPAGGSGGAGSSRIDARLLDRVRALLAKAESTTFPAEAETYTAKAQELVTRHSLDEALLAARGGDATPVVPYARRIGVDHPHEREKASLLDVVARANRCHTVSSPELAFSTVFGFDTDIDAVDLLYTSLLVQAHRAMARAEPPGGKAGRNRLKAFRQSFLVAFAVRIDERLTDAAQRALAEVTAGSGGTGVSDPADLLPVLASRDEQIRETMRQVFPHTVRARASRVDSHEGWESGRQAADRATLPTDTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Y5</accession>
    <name>F4F9Y5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Group 1 glycosyl transferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_00060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735743.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00060"/>
    <dbReference type="EnsemblBacteria" id="AEB47096">
        <property type="protein sequence ID" value="AEB47096"/>
        <property type="gene ID" value="VAB18032_00060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00060"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_11"/>
    <dbReference type="OMA" id="SYTWERT"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="206"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="400" mass="43078" checksum="A24231039753C14F" modified="2011-06-28" version="1">MRVGLVCAHAAAPTSGDGTVVGTYQHIARVAAELAGRGHDVRVYTRRDDPDVADTDLVDGYRIERAPIGPVAPTPTADLVPYVSEFGQWLADRWATDWTPEVVHGHYWIGGLAAAHAVRETDIPVVQTFHSIGMEQLRHLGPRYDGPGTRIPLERALTRAVDIAVAQCNDEVEELTRMGLQRMSVAMVPTGVDTGQFHPDGEAAPRDQRPRILSVGGLSPGHGQDDLIRAMRLVGEAELVIAGGPPAGQLAGHAEARRLRELAERVGVADQVHLVGAVPHDQMATWYRSADVVACTPHYSSAGRVSLEAMACGVPVVGYAMGGIADTVVDEVTGKLVPPGDVRTLGMTLRRLITDNAGRFAYGHAAVDRVRCSYTWERTASALERLYERVIGRRKPVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA08</accession>
    <name>F4FA08_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735765.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00175"/>
    <dbReference type="EnsemblBacteria" id="AEB47119">
        <property type="protein sequence ID" value="AEB47119"/>
        <property type="gene ID" value="VAB18032_00175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00175"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_1_11"/>
    <dbReference type="OMA" id="VEISEYH"/>
    <dbReference type="OrthoDB" id="1508493at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="35933" checksum="AE918038870D688F" modified="2011-06-28" version="1">MPPASPGPILRRRRLGLELRRLREAAGLTGDQVIDHIGWASASKLSRLENGRSRPDPQDVRDLLDLYRVDATLRAELLGITQEAGDIRGWLKNFPAMTRQQRSFAELEAGCVEISEYNPVLVPGLLQTTGYARMRITSAWQVDREAGDPEVGEDIDTEIKARLARQSLLTRDTDAPRYTAVLEEAALSHRAGPPEVLREQMTQLCELAMLPNVTLHVLPRDTPIGQWYLPPTAFSLYRFADPLDPETLAIEGGFTDVMSTEVIALNRYKVAFEWLCTAALSATDTVSWLMESAGRLSEAGVPSTVVGGSATAPTQRRGSAGRLTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA11</accession>
    <name>F4FA11_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nudix hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735768.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00190"/>
    <dbReference type="EnsemblBacteria" id="AEB47122">
        <property type="protein sequence ID" value="AEB47122"/>
        <property type="gene ID" value="VAB18032_00190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00190"/>
    <dbReference type="eggNOG" id="COG2816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_0_4_11"/>
    <dbReference type="OMA" id="VWPPGRF"/>
    <dbReference type="OrthoDB" id="1435118at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="184"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="35846" checksum="8A0C23D8D848AB97" modified="2011-06-28" version="1">MIPRAATRSGGGTGWGGVGQGTGSGGEAAPPLARSTLDRAAHRRTDTDWLAGAWAGARVLVLDVKAGGRALVRTDTDLPSLVLVEADGLPPELAAEAMFLGVEPDGVPVFCVHTELPLAPDTRAANLRQIGHLLDDRDAGLFTTALALTNWHLRHLYHPVTGEPTRTNEGGWSRVDSRGERIWPRTDPAMIVLVHDGVDGADGRCLLGNNASWPSTPGQRRFSCLAGYVEPGESAEATVLREVHEEVGVPVTDVTYVTSQAWPFPGSLMLGFLATADPAHPVRVDAAEIAEARWFTRQEVGAALAGRPVDVGGAELRLPPPSSIALFLIHRWFDGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA31</accession>
    <name>F4FA31_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00290"/>
    <dbReference type="EnsemblBacteria" id="AEB47142">
        <property type="protein sequence ID" value="AEB47142"/>
        <property type="gene ID" value="VAB18032_00290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00290"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048109_1_0_11"/>
    <dbReference type="OMA" id="WTGRANS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="178"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="32657" checksum="CA18395BE1E474B8" modified="2011-06-28" version="1">MVRRVVGIRAGRPVFSDALGELVEVTDSYLTLTTRTGQLRVPITEVHRAKRVPPTRRPAADAVIEVELAADEAWPAPTRARLGGWLLRAADGWTGRANSALPVGDPDRPLPAALDAVERWYTDQGQPPLVTTPLPLAAPVGAELDRRGWDSRPPVLVQTVGLTVLTTPPDADAGAAVIELVGAPSDEWLAVAASRKGGLPAAARHVLTAVDQVRFAHAYVDGALVAVGRGTVTGQGRWLGLSLIEVLPAARGQGHATALTRALGRWAEAAGATDAFLQVEQHNTAAVALYRKLGFVTHHTYRTRFAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAE0</accession>
    <name>F4FAE0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_11245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732038.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11245"/>
    <dbReference type="EnsemblBacteria" id="AEB43367">
        <property type="protein sequence ID" value="AEB43367"/>
        <property type="gene ID" value="VAB18032_11245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11245"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_7_0_11"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="3"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB43367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="525" mass="56272" checksum="AF9FF9692B4D4DB8" modified="2011-06-28" version="1">MTFQVYDTTLRDGAQREGVSYSVVDKLAVARLLDEFGVGFIEGGWPGAVPKDTEFFRRARTELELRHAVLVAFGATRRANTVAADDPQVRGLLDAQTPAIALVAKADLRHVERALRTTAKENLAMIHDTVTHLVAEGRRVFVDGEHFYDGYRHDPAYTASVVETALAAGAERFVLCDTNGGMLPSQVTAAITDLTDRIGVAPELLGMHAQNDTACAVANTIAAVEAGVRHVQGTANGYGERPGNADIFAVVANLQLKLGLPVLPEGCLEQMVRVSHAIAEIANIAPDTHQAYAGAAAFAHKAGLHASAIKVDPLLYNHVEPEVVGNDMRILVTEMAGRASIELKSRELGLDLAGHPEALSRVTNRVKELEAGGWSFEAADASFELLVRSELPDAAPVRPFALESYRVLVEHREDGAVVSEATVKIRVRGERVIATAEGNGPVNALDEALRVGLGRHYPELRDFELADYKVRILEGSHGTGAVTRVLVETANGRGGGWTTVGVHPNVVEASWHALVDALTYGLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAH8</accession>
    <name>F4FAH8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11455"/>
    <dbReference type="EnsemblBacteria" id="AEB43405">
        <property type="protein sequence ID" value="AEB43405"/>
        <property type="gene ID" value="VAB18032_11455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11455"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078484_2_1_11"/>
    <dbReference type="OMA" id="GAREYAD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="18768" checksum="8AAB13A6725D4EF6" modified="2011-06-28" version="1">MPVDPLDRIEELIAMVEQARSVPMSRNNCMVDRGEMIGALDELRAELPADLRRAAALLEERDKIMEAGKREADRIISEGEAEHARLVSVNEITVSAEHEGARIIAEARAEAQRLREEVDDYVDTALANFEQFLTRALASIERGRDKMHALREIGTFGGEETERPLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAJ9</accession>
    <name>F4FAJ9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="10" type="ordered locus">VAB18032_11560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732096.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11560"/>
    <dbReference type="EnsemblBacteria" id="AEB43426">
        <property type="protein sequence ID" value="AEB43426"/>
        <property type="gene ID" value="VAB18032_11560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11560"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_11"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="515" mass="54831" checksum="D532DBF72E69C56D" modified="2011-06-28" version="1">MFDTLSDRLSGIFTKLRGKGRLTDADIDATAREIRLALLEADVALPVVKGFIANVKERARGAEVSQALNPAQQIIKIVNEELVTVLGGEGRRLQFAKQPPTVIMLAGLQGSGKTTLAGKLARWLKAQGHQPLLVAADLQRPNAVGQLQVLGGRAGVEVYAPEPGNGVGDPVQVAKASLEHARRAARDVVIVDTAGRLGIDAEMMQQAADIRDAVDPDEVIFVIDAMVGQDAVRTAEAFRDGVGITGVVLSKLDGDARGGAALSVREVTGQPILFASTGEKLEDFDVFHPDRMASRILGMGDVLTLIEQAEAAFDTDQKEKMTAKLMGGEQFTLEDFLDQLIAVRRMGPIANVLAMMPGMGQVKDQLAEVDDKHFDKITAIIRSMTPAERTNPKIINGSRRARIANGSGVTVMDVNQLLNRFADAQKMMKQMGGMMGLPGGRRKATKSPKNKRKGTKGGGRPRTGAGMPGGFPGGMPQLPPGMKPEDLAAGQGLPPGFKLPKIDFNKLGKGGQPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAK5</accession>
    <name>F4FAK5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">rimM</name>
        <name evidence="5" type="ordered locus">VAB18032_11590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732102.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11590"/>
    <dbReference type="EnsemblBacteria" id="AEB43432">
        <property type="protein sequence ID" value="AEB43432"/>
        <property type="gene ID" value="VAB18032_11590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11590"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_0_0_11"/>
    <dbReference type="OMA" id="DEFYHAD"/>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="4">
        <location>
            <begin position="112"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="187" mass="19922" checksum="44FBE71581B8E524" modified="2011-06-28" version="1">MLLIVGRIGKPHGIRGEVTVEVRTDEPDTRFAPGVVLATMPGVVPRGGQEPAAEPGERYEVPDALTVEAVRWHQGRLLVAFEGVLDRDVAEALRGTLLTVDSADVAPPEDPEEFHDHQLVGLAVVTPSGERLGEVARIDHAPASDLLVLRRPEGRTALIPFVKAIVPEVDLAGGRVVVDPPGGLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAX8</accession>
    <name>F4FAX8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LppX/LprAFG lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24215"/>
    <dbReference type="EnsemblBacteria" id="AEB45941">
        <property type="protein sequence ID" value="AEB45941"/>
        <property type="gene ID" value="VAB18032_24215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24215"/>
    <dbReference type="eggNOG" id="ENOG50333DA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076599_0_0_11"/>
    <dbReference type="OMA" id="VDIWVDD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009830">
        <property type="entry name" value="LppX/LprAFG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07161">
        <property type="entry name" value="LppX_LprAFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309204" evidence="2">
        <location>
            <begin position="25"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="28970" checksum="84E6A9C4540C501F" modified="2011-06-28" version="1">MLAVSVVAAAVLTACGDTKSDAGADAPARSSALELLATDLKGSLQKTVEATEKSDSVTLTVQGSVGGEKISMTGAVELRDPIKAELTTTGSENQTVTVRIIDGVIFVEVPADQRDSMDGKSWMKMDPAAGGGQQGLEFSKQLDDVDPTKQVKTLLASEGVTVVGEETVDGTRTVHYTVTTQLADYLEQVDAKLRSAVEGQLTEQGVKEIKIDLWVDEQYRPRRVSVVMGEMSDLTIDYTDYGKPVTVETPPDAETLDLAKMIADMQNPNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB69</accession>
    <name>F4FB69_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cdp-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00650"/>
    <dbReference type="EnsemblBacteria" id="AEB47214">
        <property type="protein sequence ID" value="AEB47214"/>
        <property type="gene ID" value="VAB18032_00650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00650"/>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862312_0_0_11"/>
    <dbReference type="OMA" id="PVLWLRQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="30997" checksum="A7F23D93850A9837" modified="2011-06-28" version="1">MVRVGRRDGELHSATDALAEPRYSDRPRRRYGLQRFHRTRIETIAPAAIGPAPQVESPAPDVATVSAVPLLPGARTMARRVKFALVNACTLASLVLGINAIFIAMNGDVRVAALLLIACVAFDGLDGALARKLGVSSPFGAQMDSLADMCSFGLAAPVVVYASLAGEVPTAAAGVAAALVAACAAIRLARFNVSPQDGRFFSGVPTTMAAAVLALMVVIGLPVPGAVQIAGVALLAFTMVSSFPYAKLARLVKLPPWLWLAPVIGALIDVRLTFGLIVVGYLISGPLLWLHQRRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB84</accession>
    <name>F4FB84_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735874.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00725"/>
    <dbReference type="EnsemblBacteria" id="AEB47229">
        <property type="protein sequence ID" value="AEB47229"/>
        <property type="gene ID" value="VAB18032_00725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00725"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038123_1_1_11"/>
    <dbReference type="OMA" id="LCRADAL"/>
    <dbReference type="OrthoDB" id="1249244at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Thump_like" evidence="3">
        <location>
            <begin position="340"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="434" mass="45402" checksum="03B85E65BDD05B19" modified="2011-06-28" version="1">MDLEQLAALRTPEGSDALAAAARVAGGDPLAAAAALRSAGIPAGLAAAALTQAELRRRAAGKFGPAASGMFFTRPGLEQATRGVVARRRAHRLRKAGVTSLADLGCGLGADALAAAQAGIRVYGVEADPLTAALAEANAQATGLAELFTVECGDATAFDVTRVEAVFCDPARRRAGTGRRIFDPNSYSPPWDFVTGLAQRVPRTVVKVAPGLDHALIPAGTEAEWVSVDGNLVEAALWCGPLAETPRRATVLKEGPPVNASGSKGAPSYHLVDGTSVHQLVGSGRQEAPVGPVRRYLYDPDPAVVRAHLVAELAADLDASLADPSIAYLYADAPTSTPYARCLEVTDVLPFSLKRLRALLRARRVGRVEILKRGSALEPERLRHDLRLTGDQPASLVLTRVAAAPTVLVCQPVTSKGHGGSRQESVWPSDRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBI9</accession>
    <name>F4FBI9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_11685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732120.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11685"/>
    <dbReference type="EnsemblBacteria" id="AEB43451">
        <property type="protein sequence ID" value="AEB43451"/>
        <property type="gene ID" value="VAB18032_11685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11685"/>
    <dbReference type="eggNOG" id="COG0575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_0_1_11"/>
    <dbReference type="OMA" id="FGKHPMA"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="43512" checksum="3213AA530924D0E0" modified="2011-06-28" version="1">MSHLDPYGGAEARGWDRPDQPAQLPWPDPNLDPGPWAADPHAERYATPTAQIEPVRGAADLLHDDAPTGQIERIPAGVGLDHDDAPTAQFAPVPGDEPEADDPPPGRRHRGRRRAGRPTNGQPASSPGEQPASHLDRPAGSPGKPAAPSRAGRNLPAAISVGLGLGAVVLLPLFLYTPSFLLVLAAAFGVGIWEMSRAVRRARAVVPLVPLIVGGVLTVTIGWFGGLDALLLGLLVTIAGTLVWRLGDGMANFRRDMTAATLIAVYVPFLGGFAALLASSPDDGALRILVTLVAVVLSDTGGYAAGANFGKHPMAPTISPKKSWEGFAGSVGAAALGSALLLWLLFDVAPWWGAVFGVAVSCAAVLGDLAESMIKRDLGVKDMSNLLPGHGGLMDRLDSVLFAVPTAYLLLVVLVPAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBM8</accession>
    <name>F4FBM8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_11880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11880"/>
    <dbReference type="EnsemblBacteria" id="AEB43490">
        <property type="protein sequence ID" value="AEB43490"/>
        <property type="gene ID" value="VAB18032_11880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11880"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="OMA" id="PMPIAAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="403" mass="43207" checksum="13751625403FF745" modified="2011-06-28" version="1">MLRRFASVVDAHLEELAGLEVRNAGHTVGNARWEAGNVRDVLDYYAGAPERLTGRQIPVPGGLDVTFHEPLGVVGVIVPWNFPMPIAAWGFAPALAAGNTVVLKPAELTPLTALRLAELALEAGLPEGVFTVLPGRGDVVGERFVTHPAVRKIVFTGSTEVGTRIMSGCAAQVKRLTLELGGKSANVVFADADLERAAATAPYAVFDNAGQDCCARSRLLVQRSVHDRFLELLEPAVQAFRVGDPAAEETEMGPLISAGHRDRVAGYVDDARVAFTGGCPSGPGYWYAPTVLLTDSPADRHWREEVFGPVVSVLPFDDEADAIRLANDTEYGLSGSIWTRDVGRALRVARAVESGNLSVNSHSSVRYWTPFGGMKRSGLGRELGPDALHAFTDVKNVFISTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC35</accession>
    <name>F4FC35_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 12 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24675"/>
    <dbReference type="EnsemblBacteria" id="AEB46033">
        <property type="protein sequence ID" value="AEB46033"/>
        <property type="gene ID" value="VAB18032_24675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24675"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799120_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="197"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="347" mass="37390" checksum="7666AAA41181C949" modified="2011-06-28" version="1">MNQRTWGDRRHPAILLFAADLPVGLSGDDVCRRLAAATRFVIRLDDETDGTADDDHRPTTAALAALDRWEVRRAHLVGGASAARMARHHADRVESVSVPAGTHPGQLPVPTIPLDGPDPVLALIRLTSGGWDPQGDRLAARAIAAGDTTGWFEELYAGGVRGEVDMPWDRTFPHPLLAEWAEREGVRGAGRRAVVTGCGLGADAEFLTGLGFRALGFDVAESAIKVARDRHRGSGTEYAVGDLLDPPADWIHAFDLVVDVITVQALPEPPRHTAIVNVGRLVAPGGTLLVIAYRSDGSTYVVPPWPLTRAEIDAYGTDGLVPVRIEELTIDGGDLTARWRAEFHRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC57</accession>
    <name>F4FC57_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">(S)-2-hydroxy-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734707.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24785"/>
    <dbReference type="EnsemblBacteria" id="AEB46055">
        <property type="protein sequence ID" value="AEB46055"/>
        <property type="gene ID" value="VAB18032_24785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24785"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_0_11"/>
    <dbReference type="OMA" id="ENLSVPM"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="284"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="307"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="356" mass="37607" checksum="5D7C5A5B607BBA6B" modified="2011-06-28" version="1">MPAVPTRFVRAEDFAAVAQAVLPTDVWDYVAGGAGDERTVRANEEAFHRLTLVPRMLIDVGTRTLHTTALGVPLAGPIGVAPTSYHTMAHPDGELAVARAAGAAGLLNIVSVFSSTTLEDVAKAATGPLWFQLYCLRDRGLTRSLIERAEAAGYRAIVLGVDLPVIGYRDRDIRNAFRLPPGVRPVNLPVGTEQDPTLADLNAVLVDPRLTWQDVEWIRSVTDLPLVVKGIVAPSDAERAVQLGASGVLVSNHGGRQVDGSVATMTALPDVLDVVGGSAEVYLDGGVRRGTDVLKAVATGARVVFAGRPVLWGLAVDGESGVRAVLDLYLRELDLVMATCGCPDVASIGPHLLRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCG7</accession>
    <name>F4FCG7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42294">
        <property type="protein sequence ID" value="AEB42294"/>
        <property type="gene ID" value="VAB18032_05840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05840"/>
    <dbReference type="HOGENOM" id="CLU_2468176_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="88" mass="9771" checksum="91F4029BA04F923A" modified="2011-06-28" version="1">MSLVGARALVVPVGDPVGQRDHVRDLLHLLRVLVEFLQVRVAGDEIRDGDGPFQALLLVLEQVLPFLVEGRFPAFDLRVGDRFPGLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCN7</accession>
    <name>F4FCN7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732200.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43531">
        <property type="protein sequence ID" value="AEB43531"/>
        <property type="gene ID" value="VAB18032_12085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12085"/>
    <dbReference type="eggNOG" id="ENOG502ZE1E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2570013_0_0_11"/>
    <dbReference type="OMA" id="GDKPLGW"/>
    <dbReference type="OrthoDB" id="2230611at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="75" mass="7558" checksum="AEC562D04CD17E5D" modified="2011-06-28" version="1">MATSTVRSTSAARICTIVGFVCAVLALLLNPILFGVIGLVLGVVGAVLGDKPLGWYAAGANVVAMLLSMLILSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCT0</accession>
    <name>F4FCT0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12300"/>
    <dbReference type="EnsemblBacteria" id="AEB43574">
        <property type="protein sequence ID" value="AEB43574"/>
        <property type="gene ID" value="VAB18032_12300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12300"/>
    <dbReference type="eggNOG" id="ENOG50347E5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918107_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309248" evidence="1">
        <location>
            <begin position="24"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="303" mass="33306" checksum="2F31294181A634C8" modified="2011-06-28" version="1">MSARWLVALVTVSFFATACSSSATDPPADLSAASSDNPFSLFLGEEIGQIDYAQLKVRNKCLAKAGYPQNLNVMLGQPRNPFRHLIITARTFGPTSVEEAKRVGFGRDSLSAPPSVVSFDPNYDRAYDKCTEDAWKALSDDAKNVYYGYFDLGNKLSQPLSRTINERMGDSAWRKLLSCLDDKGHRPRSEQEFLQTPNPGLFGVPVGVDAAEGLDRWQPKQIPGTIEVGPAVPATQYQAGPVESALAVAWFECRRQTGIDKLQLETAVQVQRELVDKYESSFMELNPQVTRIAKQAAELIGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCW1</accession>
    <name>F4FCW1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733448.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18455"/>
    <dbReference type="EnsemblBacteria" id="AEB44793">
        <property type="protein sequence ID" value="AEB44793"/>
        <property type="gene ID" value="VAB18032_18455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18455"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147052_0_0_11"/>
    <dbReference type="OMA" id="RQRVACM"/>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="146" mass="17161" checksum="3D6B6DCA87986B52" modified="2011-06-28" version="1">MEDYYEYRHTVGFEETNLVGNVYYVNYLRWQGRCREMFLHDKANDVLDDLRSDLKLFTLKVDCEFFAEITAFDQLAIRMRLVELAQTQIEFSFDYVRMHPEGEVLVARGRQRVACMRGPNNRTSPSRVPEALARALAPYRVRARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD57</accession>
    <name>F4FD57_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_24945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734739.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24945"/>
    <dbReference type="EnsemblBacteria" id="AEB46087">
        <property type="protein sequence ID" value="AEB46087"/>
        <property type="gene ID" value="VAB18032_24945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24945"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_3_11"/>
    <dbReference type="OMA" id="LCTPNDT"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
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        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
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        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
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        <property type="entry name" value="PLP-binding_barrel"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
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        <property type="entry name" value="ODADCRBXLASE"/>
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    </dbReference>
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        <property type="entry name" value="SSF51419"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="23"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="30"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="422" mass="45416" checksum="F5FA24793BE2BAA4" modified="2011-06-28" version="1">MSESTALGGVPVTELVERFGTPLYVYDGATITDRYQQLRERLHPAVRMFYSLKANPNISVCALLHSLGASAEVSSLTELVTAERAGVPAEDIMFLGPGKSRTELTACLKGEVTLICESLGELALIDELAAELGTTARVVLRVNPSFAVKGSGLTMGGKPRQFGIDEAALLAESDLAGRHPSVRLCGFQAYLGTRFLSEAMIVENTARILDLAERLSQHLAVDLEVVDVGGGLGVAYFAGEQDLDVAALTDQLNPVFAAFHARHPRTVLVMELGRYLVGHSGTYAVQVRYVKESMGERFAVADGGTNHHMAAVGIGSFVKRNFPMRLLNRDSTAEPVKWNVTGPLCTPNDTIGKAVELPADVRPGDVIGVERSGAYGPTASPVHFLSHGYPAEVLIHEGEPRLVRTRDDVESMLAAQILHDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD64</accession>
    <name>F4FD64_MICM1</name>
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        <submittedName>
            <fullName evidence="8">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_24980</name>
    </gene>
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        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24980"/>
    <dbReference type="EnsemblBacteria" id="AEB46094">
        <property type="protein sequence ID" value="AEB46094"/>
        <property type="gene ID" value="VAB18032_24980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24980"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_17_1_11"/>
    <dbReference type="OMA" id="ICAFLLD"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="22"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="471" mass="48049" checksum="2B29D3C42B22B3A5" modified="2011-06-28" version="1">MTSTELPKTAPDGVQAAVQWRKVITLTASQGLSLTADYVLLVALAWTAVQLGGVGAITTLMLAGTVPRALTLVFSGPIADSLGARFVLLRTTSARAVLLAAGAVVVFTTPWFWPLVVVAAIEGVLLGIGSPAAGTLMPRLAQGEQLARANSLSSLVTRLAPIIGTPIGAWLIATGELWEAMAVVAATCGVSFAAMWVVTRGMAGGDRTPGENMLRRSGDGIRLLRTYGRLRWLFICAFLLDMAFGWPIEVALPLIVDGRGWGVGSVAVVVVAFSCGAIAAGVTGALLAHRIPLMVRLVVTGVGIGLGILAMAAMNSVFTLAAVGALVGLMAGLNGPAIVTVYQQASPRARMGTAMSMLTLAGIGTVPVSIVVFGALSAVIGVTATWFVCGFVALAAPVAALRALRQPPPGPESLGGTDTAAPSPEPEPATAEAQPTPDSQPTPEAQPVPVAFEGSDRDPADQVLVAASRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD84</accession>
    <name>F4FD84_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase PA-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25080"/>
    <dbReference type="EnsemblBacteria" id="AEB46114">
        <property type="protein sequence ID" value="AEB46114"/>
        <property type="gene ID" value="VAB18032_25080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25080"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061746_0_0_11"/>
    <dbReference type="OMA" id="LSAGWHR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="76"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="28752" checksum="4C735C960A25A1EE" modified="2011-06-28" version="1">MVLLALVQTAAFIVVWRFALYTDVGQWIDTAALTGNRIGRDHIEDPVDRILNAMSVVSLLAATVTIGFIALIRGRVALAVAATLLIAGANVTTQLLKYGLVRPDYGIDPERAYVGNSLPSGHTTVAASVAVALVLVLPPKGRAFAAVVGAAYAALAGVATLSAGWHRPSDAVAAFLVVGVWAALAGLLLLITQREQAKVSSADAHRGVALLLGIGGLLAIAGCALALSWLAGQRATAAAELPRHPLFVGYAGSAAGIAGTMGVVMALALSAVHRIVPRHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDA3</accession>
    <name>F4FDA3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_25175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734785.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25175"/>
    <dbReference type="EnsemblBacteria" id="AEB46133">
        <property type="protein sequence ID" value="AEB46133"/>
        <property type="gene ID" value="VAB18032_25175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25175"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="IAFFIAW"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="30432" checksum="FC98CDB40EBDA4D4" modified="2011-06-28" version="1">MADTTARRAKLQWGLLNAVVVVFALIPVLWIMSLSFKTPATLTDGKFIPREWTLDNYRNIFGTDQFVRALINSIGIAMIATVIAVVLGAMAAYAISRLDFPGKRLLIGVSLLIAMFPQVSLVSPLFEIERQLGLFDTWPGLILPYITFALPLAIYTLSAFFKQIPWDLEKAAKMDGATQAQAFRRVIAPLAAPGLFTTAILVFIFCWNDFLFAISLTSTERSRTVPVALSFFTGASQFEDPTGAICAAAVVITVPIILFVLFFQRRIVSGLTSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDC4</accession>
    <name>F4FDC4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase/phosphodiesterase with gaf sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_01255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01255"/>
    <dbReference type="EnsemblBacteria" id="AEB47335">
        <property type="protein sequence ID" value="AEB47335"/>
        <property type="gene ID" value="VAB18032_01255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01255"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_11"/>
    <dbReference type="OMA" id="MQAEYAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="415"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="555"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="825" mass="88841" checksum="1FEBB4480406A86C" modified="2011-06-28" version="1">MITAPLALCAVLFSLLLGLTVRPALGDWLLTLLLTVAMIIAAIPTINVVVRRQALGTTFTEIPLVVALFVLPPLSVVLAYTVATLVVQVRRKLLPPKLWFNVALAAAATALATMVYTVLPTPAGAGPATWGLLLAAIGTHALVGFIAVVAVISVVQGWQSGRELIRAVPPMSLTVAINLSVGILIIIGLESTPWAVFLFAGLAVAFALVYDTYTQVIRQHRTLTEMYELTKAITESGSDGNLIDALLVRIRSLMQAEYATLWLPAQGRHPEVLLTAQEGKPGLLDSALTPQALRDAAVTRQSTVAVGSRFGADPELRESLGRVAKDVIVVPLRSGKAVIGTLEVANRLGDVNSFRPADVPVLQTVSAHAAVALENSRLVDRLRHDAYHDGLTKLPNRRRILGALAEAVRIRAPGEVVALLLFDVDRLRQVNESLGHAAGDKVLTEVANRLRGCVPSAALVGRAGGDEFLVTLRLESAEAAVELAGQLREQIRDEMVFDALTLDVDTAVGVVVHPDHGSDPATLLQRVDVAATAAKSVPGSVQLYNPALESRSLRRLGLAGDLRSALDNGELEIYYQPKVTLRDRRLVGVECLARWEHPTHGTVAPADFVAVAEHTGQLGRLTEFVLREGLRHSRDWAHGGQSLAVAVNLSARTLNDEHFPEQVRELLAEYDVPPQLLTLEIEEAGVLDGTDRPIPSLRRLRDLGVRLSVDDFGTGSSSLAHLRRLPVHEVKVDRSFVQGMATDPGDLAIVNAVVTLSQQFGLTVVAEGVESELTLELLQDIGCEIGQGFLFSRPLPYERLEAWFGAQVDSESISSRELPRLRAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDE8</accession>
    <name>F4FDE8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="6" type="ordered locus">VAB18032_01375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735995.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01375"/>
    <dbReference type="EnsemblBacteria" id="AEB47359">
        <property type="protein sequence ID" value="AEB47359"/>
        <property type="gene ID" value="VAB18032_01375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01375"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_4_2_11"/>
    <dbReference type="OMA" id="GWARKYS"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q6" evidence="5">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="197" mass="21200" checksum="960D4939C7360B1B" modified="2011-06-28" version="1">MQLPAVLGEPIRFVLNWGRRYSLWVFNFGLACCAIEFIATSMSRHDFMRLGVIPFAHGPRQADLMVVSGTVTDKMAPAIKRLYDQMPEPKYVISFGACSNCGGPYWDSYSVTKGVDQLIPVDVYVPGCPPRPEALLHGILRLQEKIAAEQSGIGGVPRPDPLAPPTDTAPGDLSPGGGVMPRSTASLTAPPVRPPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDF2</accession>
    <name>F4FDF2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ordered locus">VAB18032_01395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01395"/>
    <dbReference type="EnsemblBacteria" id="AEB47363">
        <property type="protein sequence ID" value="AEB47363"/>
        <property type="gene ID" value="VAB18032_01395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01395"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_2_0_11"/>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="278"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="215"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="369" mass="38339" checksum="C42CA9652F81832B" modified="2011-06-28" version="1">MRDAVTTARRVVVKIGSSSLTTATGGLDDERLDALVDALDTRTVDGREVVLVSSGAIAAGLAPLGLARRPRDLATQQAAASVGQGLLIGRYAAAFARHGRTVGQVLLTVDDVTRRAHYRNAYRTLRKLLDLRAVPIVNENDTVATEEIRFGDNDRLAALVAALVDADLLVLLSDVDALWTGNPSRPGARRIAEVRDESDLAGVDIGGTGRSGVGTGGMVTKVEAARIATGFGIPVVLTSATQAVAALAGEPVGTFFHPSSKRPAARLFWLAHATSPRGRLHLDPGAVAAVVGRRKSLLPAGITAVDGAFTAGDPVDLVDTAGAPVARGLVNYDAVELPGLLGRSTADLAAALGPAYEREVVHRDDLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDF4</accession>
    <name>F4FDF4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01405"/>
    <dbReference type="EnsemblBacteria" id="AEB47365">
        <property type="protein sequence ID" value="AEB47365"/>
        <property type="gene ID" value="VAB18032_01405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01405"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959395_0_0_11"/>
    <dbReference type="OMA" id="DATCFRL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="29382" checksum="39A8983DC0D30023" modified="2011-06-28" version="1">MVDIDAAIGFVVAHGDAVERARLSWLRTGAPPSPETLDSAEVGQTLGGGWPASWGDEVASVDATCFRLAELDDLGALSRPAARRALDWLAAAQRRDGCWEEDEALADVAPEWARPGDPEARLYLTANAAFWLTVAGLDARAAGPLDHRVGGAYAGVVHAAGQALAAHLNPDGSWPSFLATGWLTAAVLHRQQLFYESARIKAVLAERLPQSTPADAAWLASTLRRVGVDEQEWTMVAARRRLTETQRSDGGWTSDDGHQFDVHTTLAVIRAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDL9</accession>
    <name>F4FDL9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06290"/>
    <dbReference type="EnsemblBacteria" id="AEB42382">
        <property type="protein sequence ID" value="AEB42382"/>
        <property type="gene ID" value="VAB18032_06290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06290"/>
    <dbReference type="eggNOG" id="COG4965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650436_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="422" mass="43333" checksum="0FC769926CD9C903" modified="2011-06-28" version="1">MSGLSWWMPALLGLITVVALPVRKLVLRTVRSRRVDGDEALVDWIVALRKADDAPIAQPPAVRPAGRDCAVRERVDARVSTAGPSASTRPPQWRGSRRPPTSSRTPFVPNGSGLGAAGPMADDSERGLRPGSSPPTWPVSNPSTRPVSSPSSPSSRSAAMRADTTGASRWPTLQPRYLLLFLLVGSGVAGLLAGPVAAVACGGYGALGVRAWHRRGGAVLRVRARRERLDQLCALAADLRAGLPVPVAAEALGLVRSVSTVRRELAASATGPTARAQRPDKPVLPDPVVPGNSTSTGDLSESAGRLAAPDRPGQLAQAAVRLADRTGAPLADLIERIEADARSADRAVAAAAAQAAGARATAWLLAALPLGGIALGYGIGADPLQVLLHTPIGGACAVTAIALQVVGLLWADRLGTVPDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDT1</accession>
    <name>F4FDT1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase small</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732281.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12490"/>
    <dbReference type="EnsemblBacteria" id="AEB43612">
        <property type="protein sequence ID" value="AEB43612"/>
        <property type="gene ID" value="VAB18032_12490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12490"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022532_0_0_11"/>
    <dbReference type="OMA" id="TYRDGGM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="145"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="494" mass="53097" checksum="A8060F7605E90411" modified="2011-06-28" version="1">MDGHDMLLSPAGVDALRTALTNADFTANGIAGRLGSAATSGVARNDFRAALRATTDRDPLATLIRVFICEQTEPETAVAAALAPLTITEALEAGLVERHGDGLRMGLDLEPYADDWWVLADVPASARPGRPLHAEHVLGIGGATQTMIGAAVRRPVETALDLGTGSGVQALHLSTHARQVTATDVSRRALRFAATTAALNGQDWELLRGDMVAPVAGRRFDLVVSNPPFVVGPGTTTHVYRDSGRVGDAIGAELAAAAPALLTEGGTMQYLANWVHVSGEDWAERVTGWFAGTGLDAWVIQREVADPMAYVNLWLTDVGDVADPQRMADWLDWFDAHKVEAIGFGIVSLRRSGHDDPVLRVEDLRQRVQAPMGDRIATWFDRQDWLREQGTDGVLAARYRAADGLRLHQEATMGDDGWGVDRQVLEMPHGLRWNEEIDPLVLALVGGADGRLPLRDQLALLAVAHDVTVDELAEAAGPIVAHLVERGFIEPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE72</accession>
    <name>F4FE72_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19195"/>
    <dbReference type="EnsemblBacteria" id="AEB44941">
        <property type="protein sequence ID" value="AEB44941"/>
        <property type="gene ID" value="VAB18032_19195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19195"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_3_11"/>
    <dbReference type="OMA" id="HDLNTAP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="91" mass="10342" checksum="C66BB5D502D56E0D" modified="2011-06-28" version="1">MYKALADPTRRAILDELQDRSGQTLFELCVRLTGKGFTSTRQAISQHLAVLAEAGLVVLRRQGRYTFIDLDTSPLQQIYQRWRVGPCESDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEB1</accession>
    <name>F4FEB1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma-24 subunit, ECF subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_25395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25395"/>
    <dbReference type="EnsemblBacteria" id="AEB46177">
        <property type="protein sequence ID" value="AEB46177"/>
        <property type="gene ID" value="VAB18032_25395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25395"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OMA" id="HTHASWW"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="19121" checksum="1B691F0AA1CCF06B" modified="2011-06-28" version="1">MNTPEGFDDFVATRSSRLLRTAFLLTRDWTLAEDLLQTALARAWEAWRRIDGDPEPYVRRILVNTYASWWRRRWRGELPTAELPEVRVAADPQTGFDDRDQLWRALGRLPRRQRAVLVLRYFEELSEHEIAEALGCSVGTVKSQASRALAKLRLDETLAPEGMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEB7</accession>
    <name>F4FEB7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734835.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25425"/>
    <dbReference type="EnsemblBacteria" id="AEB46183">
        <property type="protein sequence ID" value="AEB46183"/>
        <property type="gene ID" value="VAB18032_25425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25425"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_6_1_11"/>
    <dbReference type="OMA" id="AMQPIQE"/>
    <dbReference type="OrthoDB" id="1893149at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="16209" checksum="83BC706E2CCA3F18" modified="2011-06-28" version="1">MTARIQNAASQPDLTAGIQQLFKQVYAGGVPRHTLELVHLRVSQINGCSACVDAGATSAAKAGVRHEKLLTLAAWYDNPLFDDAERAALALAEAATRLADRPGAVTDDIWADAAKHYDERQLGALVLMVGITNLFNRINTTLRVPAGTSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FED6</accession>
    <name>F4FED6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellulose-binding family ii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_25520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the faeC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25520"/>
    <dbReference type="ESTHER" id="9actn-a0a3s0rv05">
        <property type="family name" value="FaeC"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46202">
        <property type="protein sequence ID" value="AEB46202"/>
        <property type="gene ID" value="VAB18032_25520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25520"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_2_1_11"/>
    <dbReference type="OMA" id="GYLPWYG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034429">
        <property type="entry name" value="FaeC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="entry name" value="PTHR38050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="PTHR38050:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM2" evidence="6">
        <location>
            <begin position="309"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="418" mass="43281" checksum="753FB8CD0B88B2C7" modified="2011-06-28" version="1">MATGPTATASTTDVGTLAATAGCGRAPGLNSGTHTIQSNGKSRSYILRIPANYNNNHPYRLVLGFHWRGGSAVDVDTGQTVQRDTWSYYGLRQLANNSTIFVAPQGLNAGWANSGGEDVTFVDDLLRQVEANLCVETTQRFALGFSWGGGMSYALACARPNVFRAVAVYAGGLISGCSGGNGRIAYFGAHGIRDNVLGISGGRSLRDRFVNNNGCTPQNPPEPSQGSLTHRTTTYSGCAAGYPVVWAAFDEGHIAAPQDGAPGDSGSRTWLPAETWRFFTQFGSSTPPPTDPTTPPPTDPTTPPPGPTTPPPGGACRVAVTVNAWNNGLTQDLTITNTGGSAINGWSLVFTLPGGQNITGGWNASYSPTSGQVTARNVSYNGSIAPGASVGIGFQATHTGNSARPSSYTLNGATCTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEL1</accession>
    <name>F4FEL1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01845"/>
    <dbReference type="EnsemblBacteria" id="AEB47453">
        <property type="protein sequence ID" value="AEB47453"/>
        <property type="gene ID" value="VAB18032_01845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01845"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_2_11"/>
    <dbReference type="OMA" id="EPGRMKA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="261" mass="27959" checksum="EC411C79D2BE86AE" modified="2011-06-28" version="1">MGRDGGRIAYEVHGQGPLVVLSHGMGENHHSYRHLIPLLVAAGYQVASVDVRGHGDSTTGWATYAPAEVGRDLLAVVRDLGGRPATLVGNSSSAAAVVFAAAEAPDLVSGIVLEGAFVEQPKLNPVMRLGVWAVVRSPRLFGMFHRTLFPVHRPSDDAAYRKSLVTALRRPGRMLPVREVAAPVDPHWTTVAPQVRQPVLVLMGTKDPDFPDPGAEARAARRLFPLAEARMVTDAGHYPHADRPEATAAALTDFLAVTDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF44</accession>
    <name>F4FF44_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_19235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733604.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19235"/>
    <dbReference type="EnsemblBacteria" id="AEB44949">
        <property type="protein sequence ID" value="AEB44949"/>
        <property type="gene ID" value="VAB18032_19235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19235"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092392_0_0_11"/>
    <dbReference type="OMA" id="KDANTDC"/>
    <dbReference type="OrthoDB" id="1398994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027273">
        <property type="entry name" value="Neocarzinostatin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49319">
        <property type="entry name" value="SSF49319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307679" evidence="3">
        <location>
            <begin position="27"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="26756" checksum="7666634FEDF3F52E" modified="2011-06-28" version="1">MPARLAAALVSAMLLALGALATPAYANTVGKGPNGQRLSVSKTTGIPLGGTTVTVTGSGYDTTKGIYIAYCVDNGAGVAPSPCGGGVDTTGSTGASHWISSNPPSYAEGLTVPYGAGGSFTVQVKITSKIGDVDCTTSRCVVASRNDHTRASDRSQDVKVPVTFVTPAAPSAPAAAPAAPAPATPTNTSAATTPAATGSAPAAIVGSAAAAGATDAAGGEAAPAPGAEQPLLTTQVSDSTGAGRWFTPVLAGLAVLLVVVVALRMRGRRREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF75</accession>
    <name>F4FF75_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate transport system permease protein CysT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_19390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733635.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19390"/>
    <dbReference type="EnsemblBacteria" id="AEB44980">
        <property type="protein sequence ID" value="AEB44980"/>
        <property type="gene ID" value="VAB18032_19390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19390"/>
    <dbReference type="eggNOG" id="COG0555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_0_11"/>
    <dbReference type="OMA" id="VFISGNM"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF8">
        <property type="entry name" value="PTHR30406:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="75"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB44980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="29728" checksum="2AC38A98C4CEADFB" modified="2011-06-28" version="1">MTSATLAPDRPAAPRRSVRSGLPLTRVSGLGLGVAMVWFSLLVLIPLAAVAVTAAEGGWAGFWRSVTNEQTAATIRLTVGTALLVTLVNIVMGTLIAWLLVRDRFFGKRALEILIDVPFALPTIVAGLVLLSLYGPGSPLGVNIANTRIAVFLAFLFVTLPFIVRTVQPVLAELDPEVEEAAASLGASRYTTFRRIVLPSLTPAIAAGAALSFARAVGEYGSLVLLTGNLPMRTEVASVRILSSIENDNIDSAAAVAVVLLAVSLAVIVVLDVIQRRVIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFH4</accession>
    <name>F4FFH4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acVLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25890"/>
    <dbReference type="EnsemblBacteria" id="AEB46276">
        <property type="protein sequence ID" value="AEB46276"/>
        <property type="gene ID" value="VAB18032_25890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25890"/>
    <dbReference type="eggNOG" id="COG1503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082731_0_0_11"/>
    <dbReference type="OMA" id="RWVEGFT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040783">
        <property type="entry name" value="VLRF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18859">
        <property type="entry name" value="acVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acVLRF1" evidence="1">
        <location>
            <begin position="84"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="221" mass="23345" checksum="4FE1B1401B40C9C0" modified="2011-06-28" version="1">MPYGRGMTSRPAAGGGRWVEVDPARIARWVAGFADRHGPPTVTGQEYGLLLAAPDGATAELHRPPGAPATPDLDAFVGQAVASRRIGLLLARKGAVAVGVAEGERLPVHKVDTRYVQGRTAAGGWSQQRFARRRDNQAKAALGEAADLAVRLLLPEAGRLAALVVGGDRRTVDGILADRRLAPLAALRAERLLDVPEPRYAVLQDAATAARAVRILVRDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG63</accession>
    <name>F4FG63_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732474.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13475"/>
    <dbReference type="EnsemblBacteria" id="AEB43807">
        <property type="protein sequence ID" value="AEB43807"/>
        <property type="gene ID" value="VAB18032_13475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13475"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_1_11"/>
    <dbReference type="OMA" id="QVWPGHG"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="373"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="460" mass="50043" checksum="117261F07D940A59" modified="2011-06-28" version="1">MLFTQYYLDCLSQASYLIADESTKRAVLVDPRRDIEEYLADARARGLTIDGVINTHFHADFLAGHLEVAAATGAWIGYGHRAETEYPIRKLRDGERISLGEVTLEIMETPGHTPESISILVHERADAPVPYGVLTGDALFIGDVGRPDLLASLGVTADELGRMLYDSVQRKLMGLPDEVRVFPAHGAGSACGKNLSTERQSTIGEQRRTNYACAPMSEEQFVALVTGGQPAAPGYFAFDAVLNRKARELFDPHRAARPLTAAEFAQAHAEGAVVVDTRDPQEFATGHLRGAINIPADGRFAETAGSVLSPEHRVLVVAPQDREEEIVVRLARIGFDQVLGYLREPEAAFLEMIAEMTRASRVTATELREAQERPEPPVVLDVRNAGEREQGAVEGSLHIPLAELTRRLDEVPTERPIVVHCAGGYRSSVAASLLRSAGRVDVSDLLGGYAAWQSLHAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG64</accession>
    <name>F4FG64_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13480"/>
    <dbReference type="EnsemblBacteria" id="AEB43808">
        <property type="protein sequence ID" value="AEB43808"/>
        <property type="gene ID" value="VAB18032_13480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13480"/>
    <dbReference type="eggNOG" id="COG1671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152017_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="15408" checksum="8E2829AC487B556A" modified="2011-06-28" version="1">MTESQRFATMVTCIDGRIQRPLDEWVRQHLDVDYLDTITEPGPEAVLAATGEQRLTAVLEKVAVSQQAHGSGTLVIAGHADCAGNPVSAEEHRDQLRRSVARLARRLPDTRILAVHAGQCGERCWDPELVAEVSPAPRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGI8</accession>
    <name>F4FGI8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_26125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734974.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26125"/>
    <dbReference type="EnsemblBacteria" id="AEB46323">
        <property type="protein sequence ID" value="AEB46323"/>
        <property type="gene ID" value="VAB18032_26125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26125"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962486_0_0_11"/>
    <dbReference type="OMA" id="KPEANDM"/>
    <dbReference type="OrthoDB" id="1367532at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="298" mass="33468" checksum="B4ABE20A458901A7" modified="2011-06-28" version="1">MTRAPDNLMAVRRLLLDHLNRDPNRARDEDLEPNEVGIVGDANHRGGYHCGSDRVVTNDYSVVESPRDRNGLTLDAAALDVGMFQVTVDGRRHDLASFSTWCVAQCAANAADTRDIREIIYSPDGKVVRRWDRLGRRNTGDRSHLWHTHFSFFRDSIKANRDQRPLFRRYLTSIGLITQKPEANDMTPEEHNWLKTVHRNLTVLDGRNPIGQTYTRMSMGEDHTDPKFQVGHPTLRSIGAQLTALQTAMDALMKRDFTDEQAIVAGVLAGLSPQEIAAAIPPTVAEQVVRELGRRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGM6</accession>
    <name>F4FGM6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_26315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735012.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26315"/>
    <dbReference type="EnsemblBacteria" id="AEB46361">
        <property type="protein sequence ID" value="AEB46361"/>
        <property type="gene ID" value="VAB18032_26315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26315"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059164_1_0_11"/>
    <dbReference type="OMA" id="VNAAEFF"/>
    <dbReference type="OrthoDB" id="881796at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="322" mass="32637" checksum="C656462AB4565957" modified="2011-06-28" version="1">MRKLLVIALVGLAAQLVDGALGMAYGLTSSTLLLLVGVAPAAASASVHLAEIGTTLAAGTAHWRFGNVDWRVVTRIAIPGAVGAFAGATFLSSLSTEAAAPWMAAILFTLGAYLLVRFSRPLRRNPAAGQLRGRFLGPLGLVAGFVDATGGGGWGPVATPALLVSGRMEPRKVIGSVDTSEFLVAVSASLGFLIGLGTEGFLLPIVLALLIGGLIAAPIAAWLVRIVPAQMLGAAVGGVIVLTNARILMRTAELEGSLPVLVYVLLAAGWVTALVLAVRLVLRARRQRATAAAASLQTASTDGADPGAAAAQEVTALSGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGR9</accession>
    <name>F4FGR9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736212.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02475"/>
    <dbReference type="EnsemblBacteria" id="AEB47579">
        <property type="protein sequence ID" value="AEB47579"/>
        <property type="gene ID" value="VAB18032_02475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02475"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_2_11"/>
    <dbReference type="OMA" id="TENWAVG"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="26222" checksum="39C08C74DCFE5B9A" modified="2011-06-28" version="1">MLSAVVFDADETLLDLRPAVTGGLAAVLDEMRRLTPAAAEVSLADLESDWGAVFGDMASAPVMEIRRAALHRSLARAGLGDHLDELAKVFFARRFALTRPFPDVLPALATLRQRWMLGFATNGNSRAERCGLAGEFAFEVYAHENGLPKKPAPEFYAGVCEAAGVATPSQVVYVGDNLALDVVAAQRAGLRAVWLNRRGESLPPDVLPDAAVCSLAELPAVLVGLSGEADFLLPSGYRSGETSCVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGT6</accession>
    <name>F4FGT6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02560"/>
    <dbReference type="EnsemblBacteria" id="AEB47596">
        <property type="protein sequence ID" value="AEB47596"/>
        <property type="gene ID" value="VAB18032_02560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02560"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079635_2_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="188" mass="20425" checksum="2DCB3783693EE309" modified="2011-06-28" version="1">MPLAGFGARLGARLIDFGIVFLLNVLVNGWFVARLLDEISVPLNEFGRRLQNPERNTEPLPQAGDQTGSLIVVILLIATMLWLAYEVPSMAASGQSFGKRLMGIRAVPVEADAPLGFGRALRRWNTLGLPTLLWYCCGLGLLLQLIDALSPLFDHPLRQALHDKRAQTVVVKVPRTPADGANPPGDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH77</accession>
    <name>F4FH77_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_13715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732522.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13715"/>
    <dbReference type="EnsemblBacteria" id="AEB43855">
        <property type="protein sequence ID" value="AEB43855"/>
        <property type="gene ID" value="VAB18032_13715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13715"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_11"/>
    <dbReference type="OMA" id="ALHASMM"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="5">
        <location>
            <begin position="935"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1169" mass="130546" checksum="AB0915981CB9C208" modified="2011-06-28" version="1">MTAEPETLYGADDLTHLEGLDAVRKRPGMYIGSTDSRGVGHLVNEILDNSTDEGVAGHATTIEVTLHADGSVQVDDDGRGIPTDVHARSGISGVELVLTRLHAGGKFGGSGYKTSGGLHGVGASAVNALSRRFDVTVRRSGKVHTMSFRHGVPGIFDGDGPDAPFTPGPGLQVVGAMKRGQRTGTSIRYWYDPRYFETGATLDHDAVRAKLRHTAFLVPGVSYTLRDLTAEEPTKEQFHYPNGLTDMVEFLAPAGDRPVSGTLLVTGEGTYRENAADANGVMQSNVQRRAEIEVAFRWGTGYERTVECFTNTIRNAHGGTHRKGFERALARTLADAVRNTRGLLKAKEDAPTLDDVLEGMTAVVHVRVPEPQFTSQTKDELSTAGVTKVVQGLVEQHLKSWLDDRKTKTEARTVLQKIVDAARVRLTQKQQKDAARRKTALEGAAMPAKLVDCRATGVDRSELFIVEGDSALGCFTGDTMVALASGISRSFADLAEDWQRGVTHFGYTTNKAGRVVVAPLVEPRLTKRAAPLVRVTLDNGESVRCTPDHLFRLRDGSYRRADALTPGDSLMPLYRSLSSKAAGQKLQGYERVWMNDKDEWVYTHYLADAWNLRHGRDSAANGNVRHHIDIDKRNNDPRNIQRMTWADHSALHASMMGEHVHAGWREWFANGGREFKSAMLTAQWRDPDFREACLARLFALNESPAFRAKFEQGFQDWYAALSDDQRRAYADRMRQRQAGYWSNPEHRAAAAERVRRYFADPARREQWRERSVRQWQDSELRAWRSQKTIEQFSDPAERTRQRNAVLAWHADNPEFGEHHSRRMKQRLTDPNNDHLAKVQAGRARYVATVPRGERVSRQQDGRRLAALRRLAPMLALEDGDLAAAYEAERLRSARTGLRFDRLLKLYDGDYARLREAAALVNHQVVSVEPLDETADVYDLTVEGYHNFALEAGVFVHNSARVARTAEYQALLPIRGKILNVQKANLQQVLDNAECAAIVQVLGAGSGRTFDLSAMRYGRVLIMADADVDGAHIRTLLITLFARYMRPLIEAGRLYAAMPPLHKITTKGRNPETIFTYTQAEMEATVRKLEQAGKQIVTPIPRFKGLGEMDADELWETTMNPATRSVRRITLEDVDAAERILELLMGEKVEPRRNWLIDSADRVDRDAIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHI4</accession>
    <name>F4FHI4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20280"/>
    <dbReference type="EnsemblBacteria" id="AEB45156">
        <property type="protein sequence ID" value="AEB45156"/>
        <property type="gene ID" value="VAB18032_20280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20280"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019843_1_1_11"/>
    <dbReference type="OMA" id="RMFWGDP"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="40"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="336" mass="36663" checksum="14C3CC0CA9130809" modified="2011-06-28" version="1">MPVPPLSPTQQVLSPDDVADYIAASFGADRQVADCGPLTGGGFATVWWVRLDDGADVVLKVGPPSHVPLLRYETGMLAAEARYFRLVAARAPQVPVPPVLHHGRDARLGEWLVTGRLPGRALPDLDGADAGARYDFGATVATLHRITGDRFGYDAGRAGGITWSVAFAAIVDDLLADAVDWNVTLPAPPQRFREVVARHAGLLDQVRRPALLHFDGWDGNVLAAPDAHGAYRMCGLVDGERFLYGDPMLDLVSPLLFRRAEDEPEHPFLHGYADAVGTPLVFDDRVRRRLALYRMHLHLLMTVEMPSRGITVDNDPGRHTLLAELLDRDLADLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHI5</accession>
    <name>F4FHI5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733812.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20285"/>
    <dbReference type="EnsemblBacteria" id="AEB45157">
        <property type="protein sequence ID" value="AEB45157"/>
        <property type="gene ID" value="VAB18032_20285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20285"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014554_0_0_11"/>
    <dbReference type="OMA" id="IPSHRGY"/>
    <dbReference type="OrthoDB" id="1178571at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307903" evidence="2">
        <location>
            <begin position="25"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="900" mass="96577" checksum="FF16A7C22CA93CD5" modified="2011-06-28" version="1">MRKLLISAALVVALVTGATGPAAAEPPHNPAPRSAVEGWSVADGELTWRSDTPVPMGDAAVEFWSGQRRLGAARPHPDGRTFSLPLTAPVEPDELAVRVGGRRIDADAPRESARRSEPVAAAAAPQPAGPVDPGRPGPYRQITGEYDLPGVTLPEFPEKVEMRAVVVAPQGTTGARPLALFLHGRHAVCYRGDEQVPQQWPCPAGTDPIPSHRGYLQAQRLLASQGYVTVSISANGINGQDWAAADGGAQARSSLVRLHLAKWADWARTGRAAAPSIVRAAPRADLSQVFLMGHSRGGEGVSRAAMDSLTPPPRAQDGYPGTVRWTVRGMLLIGPTLFGHNPVPDVPSVTILPGCDGDVFDLQGQMFVDATRGLSPSRALRSALYVIGANHNYFNTEWTPGQSVAPSQDDFYTRDDEPDLVCSPGMPSRLTANQQQTVGATYIAAAARLFVEGDDRIRPLLDGTGRRAPSADPARVLAHALGGNRTPVLTPDASTQLSGGARICDQVTDDAERSCLDPMDRNAFLAHFTPFLWTIPEPNRYAAELAWSRAGTPIRLAPARPVSVAGARDLALRIIVAPNTTDTRFDVTVVGTDGRRSRLGEVRIDGLPGTGNTTSHWAQEVRVPLKGAPARLAAIEVTPRTAFGQAWLLDAWGWKPGTPDPRAPRLLRLDIGTLEVAEGDSGTKTYEIPATITGRGSATVQLNLTDDMFVSRSWLATVRPGQRSIRVPAEVVGDTLWNYTERYLLTAKAQQGMVVGSYLGGLDVLNDDPAPTITVEPVQRVTEGETLTWRFTSSAPTEQGIFAIAWPQPPTDGPELSTMDVDPDWFTEHAYSPVEPERPLSQTWLVPYLDLAPDAVVAEITVPTITDSVVEPDEWIELRFDQEPDGPQLPPVLTGVVTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHX4</accession>
    <name>F4FHX4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase, PA-phosphatase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736299.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02915"/>
    <dbReference type="EnsemblBacteria" id="AEB47667">
        <property type="protein sequence ID" value="AEB47667"/>
        <property type="gene ID" value="VAB18032_02915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02915"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_3_1_11"/>
    <dbReference type="OMA" id="WPDPVDS"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="90"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="239" mass="24921" checksum="E27866F186BC9783" modified="2011-06-28" version="1">MPAAGATPSGRTPAVSLLTFLPFALLAGLVLGGWAPLHRLDVTVTEHLHGYAVAHPIWVRVMSVWTDAFAPMPLRVAALFLVLWLARRGARRLTVWVVTTMVVGGLLGPLLKLLVGRARPELPDPVAEAPGLAFPSGHALNAMLAAGVLVVVFLPRPSTPARAGQPATGAGPGVQAAVWLGALLIALVTGFSRVALGVHWSSDVLAGWLLGLAVVIATTTALGVWPRAASHRRSPAPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHZ5</accession>
    <name>F4FHZ5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736320.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03020"/>
    <dbReference type="EnsemblBacteria" id="AEB47688">
        <property type="protein sequence ID" value="AEB47688"/>
        <property type="gene ID" value="VAB18032_03020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03020"/>
    <dbReference type="eggNOG" id="ENOG50329S8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1730650_0_0_11"/>
    <dbReference type="OMA" id="NRHRVFC"/>
    <dbReference type="OrthoDB" id="1856591at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="16088" checksum="DF8776E04AAA56E8" modified="2011-06-28" version="1">MRDTENTPRAQFPSGARGGGRPVGVGALGRLPVNERSYRRPVDPPGLEPAGGRDEESPGYVIHLPIKVTDLAAATTLAGRVATSLNFLPELDAGETEVSTADDQNNRHRVFCDLLLADRTRCPQPYDHRGPCGDLPTTPEPRPASEPSGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI30</accession>
    <name>F4FI30_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_30154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8 9">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AB-18-032</strain>
            <plasmid evidence="8 9">pVMKU</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30154"/>
    <dbReference type="EnsemblBacteria" id="AEB47994">
        <property type="protein sequence ID" value="AEB47994"/>
        <property type="gene ID" value="VAB18032_30154"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30154"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_2_2_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0614">Plasmid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="7">
        <location>
            <begin position="452"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="469"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="844" mass="88185" checksum="0C9F5E614A731AB5" modified="2011-06-28" version="1">MAAKPSTPDLPCTTCPDKETPPMANTSRRRSPRRKTEAEVDRGAELARRAGEATRVAWTGTARGAGRLARRLPSPHRTPGVDQPGHDTTGLVLLLTGLLVAAAEWTNPAGLPGRILDVPAAVTGGLLGMLSVLAPLPLLWLAVEAMRHPAGRHTVRILAQAAGIVLVTAGVGGLLDLAAPGLGGLLGQITGALDGPLSVWGAVPLLVGLIAAGLTAVTRITPVALVTSLATARRRKAPVDVDDLGDLDLTDLDDFNDVDGHQDPTEASSLAVPAPAHPSPVDSVESARPVSAPSTRPRTADPAPASMSVSTTPATVGGYQLPPLSLLAAGDPPRRRPGATDPGRVALQGVLDEFKVNASVTDAHRGPAVTRYEITLGPGVKVEKVTGLAKNFAYTVGQPEVRLLSPVPGKSAVGVEVPNADREVVTLGDVIRSRAARDGHRLLVGLGKDIDGKAVTANLATMPHVLIGGSTGSGKSGCLNTLLVSLLTRATPDEVRLLLIDPKRVELTAYAGIPHLVTPIITNARKAADALEWVVREMDMRYDDMAAHGVRHVDEFNRKVRAGQITAPAGSERELRPYPYLVVVVDELADLMMVAPRDVEDSVVRITQLARAAGIHLVLATQRPSVDVVTGLIKANVPSRLAFATSSLTDSRVIIDQPGAEKLLGKGDGLFLPMGAATPTRIQGAWVTDAEVTAVVDHWRRQADTTAPAMPSSAPTSAPVDVATPTSAPVDTSVVAALSDDERTLLAEAAELVVASQFGSTSMLQRKLRIGFAKAGRLMDTLHDLRVVGPSEGSKARDVLVTPDELPDLIATLHGGQAPTDQVDRTTATTGGTVLQFPRSGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI38</accession>
    <name>F4FI38_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_30194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
            <plasmid evidence="3 4">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30194"/>
    <dbReference type="EnsemblBacteria" id="AEB48002">
        <property type="protein sequence ID" value="AEB48002"/>
        <property type="gene ID" value="VAB18032_30194"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30194"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165425_0_0_11"/>
    <dbReference type="OMA" id="ALARMIC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309353" evidence="1">
        <location>
            <begin position="35"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="76"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB48002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="24658" checksum="861629643CE36548" modified="2011-06-28" version="1">MGRRDRVGGGPVKALTKVLLPAAAVVSVVGHVWAAYAVRSQQTELGRARREATTDPLTGLANRAGLAAALDELDGEPYDLVLVDLDKFKPVNDTWGHAAGDRLLVEIARRLAAVLDDIDGAVVARIGGDEFVLASPSPAALAHYLGAEVIQALGAPIEVADAVTVTVTASVGAVHATAGEDPARAMAAADAAAYEAKLRGGDGLVEHCPLTELPEVEQRPLLRLREMVDLTTALGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI45</accession>
    <name>F4FI45_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
            <plasmid evidence="1 2">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713131.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30229"/>
    <dbReference type="EnsemblBacteria" id="AEB48009">
        <property type="protein sequence ID" value="AEB48009"/>
        <property type="gene ID" value="VAB18032_30229"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30229"/>
    <dbReference type="eggNOG" id="ENOG5030MHW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2393247_0_0_11"/>
    <dbReference type="OrthoDB" id="2213876at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB48009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="83" mass="8885" checksum="94A5AB8C2EA09877" modified="2011-06-28" version="1">MTAKRSISVPDDVAQWLDGQPNVSAAITAAVRAQMAGARLDEALRRAGIEVTDAGKARWRDRLATPIPDEALAEGQRMLDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1P5</accession>
    <name>F4F1P5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ordered locus">VAB18032_26986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735121.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26986"/>
    <dbReference type="EnsemblBacteria" id="AEB46470">
        <property type="protein sequence ID" value="AEB46470"/>
        <property type="gene ID" value="VAB18032_26986"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26986"/>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_0_1_11"/>
    <dbReference type="OMA" id="NPRGWAT"/>
    <dbReference type="OrthoDB" id="1088517at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="32"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="290" mass="30130" checksum="8ADA01D87C074A7E" modified="2011-06-28" version="1">MTATQPGHRPIGSHTPTSGGLAKAALPYLDAAGSEVAQVYVGNSRGWAMPAGDPVQDALFRDGCAERGVAAYIHASLLVNLGSPTPATVERSQQTLAHALRRGAAIGARAVVFHAGSAVDAGHAEAAMRQVRESLLPLLDSAADSGGPMLLVEPSAGGGRSLACRVEQLGPYLDAVDRHPWLGVCFDTCHAWAAGHDLAAEGGMTETLDTLVATVGADRLQLVHANDSKDLCGSTRDRHENIGKGSIGEPAFAELMRHPATAGVPILVETPTDRHEGHAADIATLRRLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2G7</accession>
    <name>F4F2G7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LemA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_14635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14635"/>
    <dbReference type="EnsemblBacteria" id="AEB44039">
        <property type="protein sequence ID" value="AEB44039"/>
        <property type="gene ID" value="VAB18032_14635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14635"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_2_1_11"/>
    <dbReference type="OMA" id="YNNAVQA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="198" mass="21543" checksum="DB86906B0F9C62ED" modified="2011-06-28" version="1">MEVIIGLVCLVLIVVAVLGFGVSIYNGLVRARNTYRNAFAQIDVQLVRRHDLIPNLVETAKGYLKHERETLEAVIKARNAAVNAQATAAAAPGDPAAMQQLSGAENALTATLGRLFALSEAYPDLKANQNMMQLSEELTSTENRVAFARQAYNDAVMAYNNKREVFPSSLIAGMFSFGPAALFEPDDPQQRQAPQVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2K1</accession>
    <name>F4F2K1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_20830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733920.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20830"/>
    <dbReference type="EnsemblBacteria" id="AEB45266">
        <property type="protein sequence ID" value="AEB45266"/>
        <property type="gene ID" value="VAB18032_20830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20830"/>
    <dbReference type="eggNOG" id="COG3879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040273_1_0_11"/>
    <dbReference type="OMA" id="RVRDRDM"/>
    <dbReference type="OrthoDB" id="1508768at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="301" mass="31917" checksum="8165076FEEF7514F" modified="2011-06-28" version="1">MSERVGDDDERRGVRTFTPDFLTELFRNPLDPGYEDAAQARARRGGSPRPGWTVSPVSLVLIVLLGFLCAVAYRQTTAEESGRAQARSGLVAQIKQRQADTDAMSERADQLRDEVNRQREAQLSGSQASRLRNLAASTGLGRVRGDGVVVRLEDGPSGQDGLGGANVGPSQVLYSDLQGVANDLWGAGAEAIAINGQRLTATSTIRNAGQAILVDFRPVTGPYEVSAIGPRSMRERYEASRSALTMRKVAQDTGLSFGVRQVDDLTLPAAPEPRLRYAEPAVSPSVSPSGGGSPSPSGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2W5</accession>
    <name>F4F2W5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_27516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735226.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27516"/>
    <dbReference type="EnsemblBacteria" id="AEB46576">
        <property type="protein sequence ID" value="AEB46576"/>
        <property type="gene ID" value="VAB18032_27516"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27516"/>
    <dbReference type="eggNOG" id="COG3766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135044_0_0_11"/>
    <dbReference type="OMA" id="AFLVLDW"/>
    <dbReference type="OrthoDB" id="1874412at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="14444" checksum="C21F060B637BE9E5" modified="2011-06-28" version="1">MLEDLLSGAWQSVVFGVVGVGLMAAGFGLVDLLTPGKLRDLIWVRRNANAGLLLAANQLGVAGIVFTAILTSYHDFAKGLASTVLFGLIGLGIMALAFVVLDLLTPGKLGEVVCSDEPHPVAKVSAASHFGAALIVCACIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F310</accession>
    <name>F4F310_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736421.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03525"/>
    <dbReference type="EnsemblBacteria" id="AEB47789">
        <property type="protein sequence ID" value="AEB47789"/>
        <property type="gene ID" value="VAB18032_03525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03525"/>
    <dbReference type="eggNOG" id="ENOG50321MC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097904_0_0_11"/>
    <dbReference type="OMA" id="FRGRHDE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="205" mass="22437" checksum="274FEDC421EBC43B" modified="2011-06-28" version="1">MGGEWLVNENIDVDVNQLQDFARAIQKELDTNFQPSFENGLRPMLTVQAPFGGGGMKEAAFFRGRHDESRMAVSHLMGDVIKGLTALSAAATSISGEYLLGDALAEATNDDVYNAFNAVDGQNTLSGKWQQEGDPMEEIPEQARDPEVVGPYHGMDSCPTEDTREQAPEWAAAETVGNGPGAYQIEAEDQRMHGEEFRLDQSNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F334</accession>
    <name>F4F334_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03655"/>
    <dbReference type="EnsemblBacteria" id="AEB47813">
        <property type="protein sequence ID" value="AEB47813"/>
        <property type="gene ID" value="VAB18032_03655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03655"/>
    <dbReference type="eggNOG" id="COG2170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044848_0_0_11"/>
    <dbReference type="OMA" id="CCGCHVH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="358" mass="39099" checksum="DB8FB12F7D237D43" modified="2011-06-28" version="1">MEEEFLLLDPETGESLPVAEQVLDALSGTARTQSRQEFRHSMLEMVTPVCADLTQLREHLITLRRAAAEAASTAGARLVAVGATPVCEAHLTVPDEQRYHAMSRRFGPVAHDPAVCGCHVHVGVADRELAVQVCNHLRPWLPVVQALTANSPLYDGRDTGHNSWRSMQLERWPSIGPTPHFESVADYDATVQELITAGIMLDAAMVYWYARPSTKYPTVEVRVGDVCPSVEDTVLVAALVRALVVTMIDRVRDGVPPVRIRDCLVAAAHWRAAHDGVDGVLVDLLGGGARPAWDLVDDLLDTVTPALARYDDLDLVLRQVDRLRREGTGATRQRRVMAGTDGDVQAVLQHLIAQTVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F385</accession>
    <name>F4F385_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731480.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08455"/>
    <dbReference type="EnsemblBacteria" id="AEB42809">
        <property type="protein sequence ID" value="AEB42809"/>
        <property type="gene ID" value="VAB18032_08455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08455"/>
    <dbReference type="eggNOG" id="ENOG5033G9D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_661910_0_0_11"/>
    <dbReference type="OMA" id="PQWRHLL"/>
    <dbReference type="OrthoDB" id="601886at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="415" mass="45217" checksum="6E2EA0D416BE2C13" modified="2011-06-28" version="1">MSITPRAEGAAPEQTGLRVAYGGAVYPAEEIARGAAYELFSPHEVPGFQWAPRPNSALPWRRFVHVTEVGAVHCPTEPAEEPEAPLLVPLHRERGWSEVHRLSQQPNAADDPLVRAVRASAIIRRGTRMVKILSARQLAGHVRGWLPHGFCYREHDVAHLRTPAATSVLRTDGGGGGDAAEVTYALRWRAADPGDYDVPAGVAYRGLTALGARDRLGPAVLGTGFAPSSSQLVPEFVTRDFADLPMPANATLLAYPAEGIEVVLYVYQAEQRGWLRMVGPQWRHLLAAVPGLSPDQEYVPTGAAPWSTRLVGTYAGGEYEAVADLPGGFRVLALTRAARYPVDGVSRRLRQATWRGVPCLVLSEEADWLRLRLRHPNPDAVAVTGAQCHERGVYETWAPGSEVTDDRVIDHPYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3D2</accession>
    <name>F4F3D2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731527.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08690"/>
    <dbReference type="EnsemblBacteria" id="AEB42856">
        <property type="protein sequence ID" value="AEB42856"/>
        <property type="gene ID" value="VAB18032_08690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08690"/>
    <dbReference type="eggNOG" id="ENOG5032YFK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1239010_0_0_11"/>
    <dbReference type="OrthoDB" id="1961509at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24067" checksum="EE90D3E9933BBB02" modified="2011-06-28" version="1">MPVGDDVLVEEHLRQLAARLHGPRRLRADLLTEARHGLLDTVEAYRDGGLTGDEAARRAVAEFGTPEQLAPAYQAELAVAALRRLALWIVAFAGVAAIAGDLTWHGSSWSGGPPPPTGYLLLSRSVDVIWTAAFLFGAAGLVLVAMTARSSRPGFTVAAHTTGILLTGTTLLGAMAGVALFGWSIALWDAALSWPPMIVGMLVAGAAHLWLGRTAHTWLLAARPLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3E9</accession>
    <name>F4F3E9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08775"/>
    <dbReference type="EnsemblBacteria" id="AEB42873">
        <property type="protein sequence ID" value="AEB42873"/>
        <property type="gene ID" value="VAB18032_08775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08775"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091682_0_0_11"/>
    <dbReference type="OMA" id="FPGRVHT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="215" mass="23186" checksum="9B4892F447B795E7" modified="2011-06-28" version="1">MGGITMRLTKYAHSCVRIEHDGGVLVVDPGMFSEAAVALDGADAVLITHEHPDHVDAEAINRQLARRPFVIHGPTSVSKVLGDAAEALRPVSPGESFTAAGVPVRAYGGRHAVIHPDIPVVDNIGYLFNDVVYHPGDALFVPQDVPVDTLFAPIHAPWSKFSEVVDFIRAVAPRRVFALHDALLNTNGLTVLDRQYTALSGSEYQRLEPGSRIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3H2</accession>
    <name>F4F3H2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732747.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14840"/>
    <dbReference type="EnsemblBacteria" id="AEB44080">
        <property type="protein sequence ID" value="AEB44080"/>
        <property type="gene ID" value="VAB18032_14840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14840"/>
    <dbReference type="eggNOG" id="ENOG5033A8E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167343_2_0_11"/>
    <dbReference type="OMA" id="IAFRKIT"/>
    <dbReference type="OrthoDB" id="2087009at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307390" evidence="1">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="11251" checksum="483387C7EE474FA7" modified="2011-06-28" version="1">MRRLFWLGIGLAVGVVVVRKATRAAHAYTPAGIADNLSQSAGGLVEELRSFVADVRAGMAEREQEIHEAFAQGEAFDDQFAELREDPRLGDREIFPEEHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Q6</accession>
    <name>F4F3Q6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21285"/>
    <dbReference type="EnsemblBacteria" id="AEB45357">
        <property type="protein sequence ID" value="AEB45357"/>
        <property type="gene ID" value="VAB18032_21285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21285"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655436_0_0_11"/>
    <dbReference type="OrthoDB" id="1609859at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="45793" checksum="55D0F382ED7E9239" modified="2011-06-28" version="1">MLARLPLRPEQVRGVDEPDPSFGAGTVSCGRPLIFPVPVEDLPVELRRRAQASGRHYYGLLVAFDLNEPPDARRYTSVRFEVALDDAEAVAVRLDRDGGTLGLSYAASSPHPLTPAADRAILAATTRQGWLLRLAPRSGRPRAWSFGLHRHRFGWTYEDPSGAMFLPLTYGMHAMIEVPPSTRLLSGRIGLRVETLGTWRHRPVHRSATLADSVAFREALPENPVPSGAAVRLCLAADVTGYSRRPNHLAERTQSWLVRSLAEARAGAGLDEATVVVQAQGDGQFAVLPVGIDESRVIPDLICGLAEALRRTNDGLSAEERVRLRVALHRGLMKPADSGWVGTAAIAVHRILDSPPLRAAIRDTPTADYVLGVPDLLYQDVIRHSVVPPLPHQFTEITIDLPDKGFVEHGWLHVPVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3R0</accession>
    <name>F4F3R0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734015.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21305"/>
    <dbReference type="EnsemblBacteria" id="AEB45361">
        <property type="protein sequence ID" value="AEB45361"/>
        <property type="gene ID" value="VAB18032_21305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21305"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023673_0_0_11"/>
    <dbReference type="OMA" id="FWIYTRA"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="268"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="520" mass="57670" checksum="62529998F9E26BB4" modified="2011-06-28" version="1">MSHYDEARRDLDSYIAARVPLIGIRTPEQVRAVRLLREVASSTRRVNLPFSIYTRATGLRDLRTNNSLQDDRSLVAAMDFAASQFTRRAQATTAFVDPDMLDADSSVTRHMAELARLADDHSGSIVLITDTPLWSGLQRLGMSITLEPPNVDEMYDIVVGFLKEQQGAITIDWTATDARRAAQFLVGVPEGTAVNILATIATAGRLHREDLDRLTEVKDKHFSDLAGLERVPLGPADRMIGGLHQLRTWLDRRHKVMLSDLRETSLRPPRGVLLVGVPGCGKSLSAKAVAAQWRLPLYRLDFAAILGMYVGQSEARLREALEMADRTAPCVLWIDEIEKGLSGQYDSTGVSRRMVGQFLYWLQESRSRVFVVATSNDVRSLPPELLRKGRFDELFFVDLPDETERAEIIRLYHGRYLRTEPDDELVGRLVAASDGFAGSDIEAALRELGYTVHTEGTTSLRPEFVVDTFVNTNPMSRTHPEEIAELRAWGRERAIPAGAAGAAGTPAAGGRRRVIVPGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Z5</accession>
    <name>F4F3Z5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_27841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735291.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27841"/>
    <dbReference type="EnsemblBacteria" id="AEB46641">
        <property type="protein sequence ID" value="AEB46641"/>
        <property type="gene ID" value="VAB18032_27841"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27841"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_1_11"/>
    <dbReference type="OMA" id="RAPHEDT"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="5"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="27431" checksum="22D42C162C8EB0AB" modified="2011-06-28" version="1">MTLRVLITNDDGIAAPGIHALARAAVDRGLDVVVAAPLEEASGTSAAMSAIEQDGRVVVHEHPLPDLDGTPAFAVGGSPGFIALIAVHGAFGPPPQVLLSGINRGANAGRAVLHSGTVGAAFTAAANGCAAMAVSLDVLSVGEATAASGGAAVAAAARVRDADRYWSTAARVALDLLPRLPTGPVASVLNVNAPDLPYERLRGVRRGSLATFGQVQMTVAEAGHGFVRTSLEEPGQAVQPGTDLALLAEGYASVTAIRAVTEATDIDLSGLDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F401</accession>
    <name>F4F401_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein LuxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_27871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27871"/>
    <dbReference type="EnsemblBacteria" id="AEB46647">
        <property type="protein sequence ID" value="AEB46647"/>
        <property type="gene ID" value="VAB18032_27871"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27871"/>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006325_1_0_11"/>
    <dbReference type="OMA" id="SDWVSNA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="858"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="925" mass="98048" checksum="3D645DFABD2DEAF1" modified="2011-06-28" version="1">MGRMPDDRSEVRGAARARTPGGPAVLASRLSPAVLPEPVVLRPRLARLLDEAVARPVTLLRAPAGWGKTTLLASWRRTATQRDSGTPPPAWVSVEAGDDAERLWAYLAAALRSIIDVAATPIPDRPPGPDELEVLAAALAAREQPAVLVLDDLHRVTDPAAVAGLEFLLRHTDQRLRLVVTGRSGPPLAVQRLRLAGELTEIGPDELAFTGDEIADLLTAHAVAVPVAAVRRLRQRTEGWAAALRIAALALRQQPDPERWIDQLGADHPEIGGYLREEVLAGLTPQDRELLRRAAVVDTVCAGLAGALTDDPSVEGRLSGLAEDAGLLHHDGGRPAWYRCHPLLADLLHRELGRLPADELRDLHLRAAGWYAGNGRPAEALRHALAAENWVSAVDLFVTRWPELVPNGRVDRDVPAAAPPPEAVARDPELALACAADRALHGDREAAQTQLRLAAEHGGALPEPRRGRFGRLAAAVTLTLARATGDPETVRAAAARLLATASAAGAAPVARVEERAAGQTPRGDAGDDADVRAVAGTELARLALDAGELTEAADGFAASLTAARVTGRLRPELVCASRWALLAALRGHLRAAEEAARAALALPPCQGWSAQLDCGYAYLALGFVALHRDQPAEAAANLTLAAAATGEAPAGAVAAWCHSMLRHDEGDLVEAHRLLGQARECWSQRSGPVAAWLLAADVDLHAARGDLSTARELAAAGMARFTSPTQAGPAFPAAVLSVAAARVELRAGDPHAAARLLPDWAAGPATDWPLPVRLDAALLDAVLAGRGGDERRAGRTLEQALDLAAPDGYRRPFTRAEPGLRHLLTAHLDAGTAHWPMVSDLVRAVDPPADLAASGASVAPLDEPLTERELTILRYLQSILSNVEIAAELSVSVNTVKTHVRNIYRKLDATRRRDAVRRARELHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F464</accession>
    <name>F4F464_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component transcriptional regulator, lyttr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_03975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736509.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03975"/>
    <dbReference type="EnsemblBacteria" id="AEB47877">
        <property type="protein sequence ID" value="AEB47877"/>
        <property type="gene ID" value="VAB18032_03975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03975"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_11"/>
    <dbReference type="OMA" id="DIHMPDF"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="28567" checksum="A966D54030F87BAD" modified="2011-06-28" version="1">MTGNGGTPGFLRVLAVDDEPPALDELAYHLRTDPRVARLHTAGDATEALRVLRDDEVDVIFLDIRMPGLDGMELARVLRQFARPPAIVFVTAYDDGAADAFDLGATDYVRKPVRAERLAEALRRVVGSRVLPSHPAALARAEEDPTIPVELAGSTRMLPRSAVRWVEAQGDYARLHTTEGSHLVRVSLATLAERWADAGFVRIHRSYLVQLRLIAELRLVNSGYVVVVDDAELPVSRRHTRELKDKLVRAAKQEWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F483</accession>
    <name>F4F483_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04070"/>
    <dbReference type="EnsemblBacteria" id="AEB47896">
        <property type="protein sequence ID" value="AEB47896"/>
        <property type="gene ID" value="VAB18032_04070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04070"/>
    <dbReference type="eggNOG" id="ENOG5032SHB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1288440_0_0_11"/>
    <dbReference type="OMA" id="RPSPLEW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="23062" checksum="A46EC1D6F4B77428" modified="2011-06-28" version="1">MAARPSPLEWARRRRAERGARRLEAAGARALGQLGHLGPAWHVVDWPRVDPADVLLDESDDNRAGFLAIGPSGLFAVTIADHGRARVLVAGDVVQINGKRPPYVTEARRDARRASKALTAAVGHPIPVTPVLTFVGSGVISVYGLPKDCLMATHRELDRLLVAGGNRISPATAEKLSRVAQHPSTWTTGGHQPAADYRWYEDGRTAADKAATHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4C0</accession>
    <name>F4F4C0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor synthesis domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736565.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04255"/>
    <dbReference type="EnsemblBacteria" id="AEB47933">
        <property type="protein sequence ID" value="AEB47933"/>
        <property type="gene ID" value="VAB18032_04255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04255"/>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_4_1_11"/>
    <dbReference type="OMA" id="EYLTSEW"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="15829" checksum="D2CB35D00EA42777" modified="2011-06-28" version="1">MIRARVVVASNRAASGVYADTSGPLLVAGLREWGCAVDEPVVVPDGEPVGLAIRQAVADAVDVVLTSGGTGITPTDRTPDVTRALLDYEIPGIAEAIRAHSRDKVPTAALSRAVAGVAGRTLVVNLPGSTGGARDGLAVLGPILTHAVEQLRGGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4P4</accession>
    <name>F4F4P4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemolysin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_15370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732851.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15370"/>
    <dbReference type="EnsemblBacteria" id="AEB44186">
        <property type="protein sequence ID" value="AEB44186"/>
        <property type="gene ID" value="VAB18032_15370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15370"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058015_2_0_11"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="OrthoDB" id="1670446at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="3">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="284" mass="29288" checksum="42B11B7EDD61203C" modified="2011-06-28" version="1">MARRNRLDAELVRRGLARSREQAAALVEAGRVQLRGVRAHKAAAMVDPADPLLVTGDDPTSEYVSRGGHKLAGALAAFSPGGLTVAGRRCLDAGASTGGFTDVLLRAGAAEVVAVDVGYGQLAWSLRNDERVRVFERTNVRTLTTDVIGGPVELTVADLSFISLRLVLPALAGCTDGDLVLMVKPQFEVGKERVGAGGVVRDPALRAEAVLDVAAAAAGHQLGLVDVAASPLPGPSGNVEFFVWLRRGAPPADPERVRAVVAAGPQGPTMSGEVPGAATEEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4P7</accession>
    <name>F4F4P7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamin pyrophosphokinase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_15385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732854.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15385"/>
    <dbReference type="EnsemblBacteria" id="AEB44189">
        <property type="protein sequence ID" value="AEB44189"/>
        <property type="gene ID" value="VAB18032_15385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15385"/>
    <dbReference type="eggNOG" id="COG4825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046690_0_0_11"/>
    <dbReference type="OMA" id="MIIGDMD"/>
    <dbReference type="OrthoDB" id="1297228at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022215">
        <property type="entry name" value="SteA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12555">
        <property type="entry name" value="TPPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="TPPK_C" evidence="6">
        <location>
            <begin position="334"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="392" mass="41616" checksum="614905491338EBEA" modified="2011-06-28" version="1">MRLPTLRRARNAEPGQILGTARLDRRTKRLVGRLRPGDIAVIDHVDLDRVAADSLVAVGVGAVLNAKPSVSGRYPNLGPEVLVSNGIPLLDDLGEGIFERIREGDTVRIEGNTVFLGDDPVAHGSLQDAESVAKAMTDAREGLSVQLEAFAANTMDYLRQERDLLLDGVGVPDIVTEVQGRHCLIVVRGYDYKADLDVLRPYIREFKPVLIGVDGGADALVEAGYTPDMIIGDMDSVTDDVLRCGAEVIVHAYPDGRAPGLSRVNGLGVSAVTFPAAATSEDLAMLLADEKGASLIVAVGTHATLVEFLDKGRGGMASTFLTRLKVGGKLVDAKGVSRLYRQGISGSSLLLLVLSAVAAMASAVAVSTVGKAYLGVVSEWWDNFVFQLGQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F520</accession>
    <name>F4F520_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735352.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28156"/>
    <dbReference type="EnsemblBacteria" id="AEB46702">
        <property type="protein sequence ID" value="AEB46702"/>
        <property type="gene ID" value="VAB18032_28156"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28156"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_0_0_11"/>
    <dbReference type="OMA" id="GWVVVND"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="117" mass="13149" checksum="6C22926361887F22" modified="2011-06-28" version="1">MTVVWASLTIDARDPARLARWWAEALGYQVITEQPDEVEIRQSVDRLPGIVFVPVTGAKESKNRLHLDLRPADREAEVERLVDMGARHVDVGQDGTDWTVLADPEGNEFCILAPRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5D6</accession>
    <name>F4F5D6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731639.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09250"/>
    <dbReference type="EnsemblBacteria" id="AEB42968">
        <property type="protein sequence ID" value="AEB42968"/>
        <property type="gene ID" value="VAB18032_09250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09250"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052321_0_0_11"/>
    <dbReference type="OMA" id="HVREHHA"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="219"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="458" mass="49169" checksum="8D74771943A5E4A0" modified="2011-06-28" version="1">MRLADRSAPANWAPTSALGRAVLLTGLLLVAAVLLGRVDLIVLAAPFALGTAYALRNRPTELPRVWVSVDEGHLVEGGELVGRVSVGNPDATPYDVAVLRTRVSPWLRIEQATLAGGAVSGRSGDRRSVTDRPFVTSVDPDTAVDLELTGTALRWGRHPFGPAGARVAAAQGLLVSRAVIAEPVVNRVYPKTEPFEAVNAMPRAAGLVGAHHSRRAGEGGELAGVRVFAPGDRLRRIDWRVSLRARQLHVAATLSDRDAEVVVLLDVLAEAGRSGGIAGAATVLDTTVRAAAAIAEHYLHRGDRVALLEYGPNARRLRPATGRRQYLTVLEWLLDVKAQHSPHEPYDQVFGSQLLSADALVVVLTPLLEERSAQMLARLARSGRFVVAVDTLPADLSPPKDRGWAEVAYRLWRLDRDTMIAQLREHGVPVVPWAGAGSLDQVLRDVARLATAPRVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5E3</accession>
    <name>F4F5E3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_09285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731646.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09285"/>
    <dbReference type="EnsemblBacteria" id="AEB42975">
        <property type="protein sequence ID" value="AEB42975"/>
        <property type="gene ID" value="VAB18032_09285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09285"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050180_0_1_11"/>
    <dbReference type="OMA" id="NDVTHRM"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="80"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="36220" checksum="B1CD404B7FF06EB0" modified="2011-06-28" version="1">MGAVGSVVPDRPRLQRAWRVARLAAFGTGATAAAAAAATGILLGQARQARRTIPMAEAPPPRCDGVYGAKFPGPALNLVVLGDSSAAGYGVHRRRETPGSLLATGLSRRLQRPVRLRCFAVVGAISAGLKFQVEAALEGDPDVAVILIGGNDVTNRAPLGLAVRHLVEGVRALRAAGAEVVVGTCPDLGTIRPIQPPLRWLARRWSRQLAAAQTVAVVSAGGWTVSLGDLLGPRFTAEPGRMFAWDRFHPSAEGYAVAAAAILPTALAALGHGAERRPSPTRVEGVRSLPKAAHEAARHPGTEVSGTQVRGSESGPGGRWAQLRRRGLFGVGAVSQPAGADSPAVEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5F5</accession>
    <name>F4F5F5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09345"/>
    <dbReference type="EnsemblBacteria" id="AEB42987">
        <property type="protein sequence ID" value="AEB42987"/>
        <property type="gene ID" value="VAB18032_09345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09345"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_4_11"/>
    <dbReference type="OMA" id="NDGMGSL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="469" mass="48780" checksum="2C1022715104D8C4" modified="2011-06-28" version="1">MQDIMPTWVGATAKQIARGVRRGDVSATQVLADHLDHIAKADADLAAFRTVRGGEAVTEAEKVDEQEDLANLPLAGVPVAVKENTPVAGVPTWNGSATVRTTVAEADHEVVRRLRGAGAVILGVTRMPELGLWAVTDDDTAVTRNPWDLTRTPGGSSGGAAAAVAAGLVPIAHGNDGLGSIRIPAACCGLVGLKPGRGVVPCQLGAEDWFGLTEHGMLSTTVADAAVGFQVLAGRAQQKLVPPQRLRVGVSLRSPVRGVSADAPNRDAVAAAGRLLAAAGHDTVPADPVYPTALGLQGIATWFAAAAADVRAAGIERRSLQPRSRRHVALGEWALRRGYVREADRLAWRERSVGFFTDHSVDLLLTPALAAAPPPAASWSARSWQANMLASIRYAPYAAPWNVAGLPALVVPVGRRPDGLPLAVQLVGPPGSELLLLGVAGQFEMEAPWSRHAPGYPRVGTGLPGAVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4F601</accession>
    <name>F4F601_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45560">
        <property type="protein sequence ID" value="AEB45560"/>
        <property type="gene ID" value="VAB18032_22300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22300"/>
    <dbReference type="HOGENOM" id="CLU_3241124_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="43" mass="4575" checksum="6D03B9A99274579B" modified="2011-06-28" version="1">MEVPDVVVRYASSSRCRSAAPMRASGAGSVIDQWFAATSTRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F629</accession>
    <name>F4F629_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase like protein, ahpd family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28551"/>
    <dbReference type="EnsemblBacteria" id="AEB46781">
        <property type="protein sequence ID" value="AEB46781"/>
        <property type="gene ID" value="VAB18032_28551"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28551"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_6_0_11"/>
    <dbReference type="OMA" id="NRFGVTC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="143" mass="15906" checksum="94FD7EE7C70D54A7" modified="2011-06-28" version="1">MDVAEVAPEAYQSVLGLEKYVRANVEHTVLELVKLRASMLNGCAYCVDMHSRDAMDAGESHRRLFAVAAWREAPFFDERERTALALTDAVTRLGEHGVPDDVWAAAAKVWPEKALADLVLAIATINVWNRIAVTFRKDLPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F649</accession>
    <name>F4F649_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735450.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28651"/>
    <dbReference type="EnsemblBacteria" id="AEB46801">
        <property type="protein sequence ID" value="AEB46801"/>
        <property type="gene ID" value="VAB18032_28651"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28651"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816222_0_0_11"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="210"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="34213" checksum="0F7BE30D98CEDCE8" modified="2011-06-28" version="1">MTGALLLAAQLALGGTLGWALAGKVRNRAAFATFRASLPRTVGVPAARAGALAVGVLAAEALTAATLLAAVAVPALAPTAFALATGLFAAFTVAVAGMVRRGVREPCRCFGVTERPPGPAHVVRNLLLTAVALGGAALAFGGVRPPSPPTLTADPTGGDMALTTVLLLVVTVLCLVNTTVLLVVLAQLRRQSTLLKVSIEGVENPEPIMLTAGATIGDFTATTVDGTPVSRAGLRGETLVAFLSPSCPACAESLPGFVARAEAIPGGREQALAVVLGAGEAATQLCERLTPVARVVNEPERGPVARAFGVDGYPAFGLLSGDTVVASHFVLDRVPATNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F677</accession>
    <name>F4F677_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C60 sortase A and B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_28791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28791"/>
    <dbReference type="EnsemblBacteria" id="AEB46829">
        <property type="protein sequence ID" value="AEB46829"/>
        <property type="gene ID" value="VAB18032_28791"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28791"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062592_2_0_11"/>
    <dbReference type="OMA" id="NLRLITC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="29602" checksum="82F54049F27E76E1" modified="2011-06-28" version="1">MIGHRVPVPEPRPAPPRTVTRRSYRLWRTVTAVAGRLGRVTAQMGSASIATPDPSAAPVPPRPRRAWPAAARRSLRASPGLPVLVIGSLMLLIITMLGVERLTGTNLLPDRFIAGLAPPPKKFPLLPASQPVGIEINKIDLAAPVHNVGVAADGSIAAPTAERAQEAGWYDQGPTPGQYGPAVIVGHVDTSTGPAVFQDLRQLRAGDRVEVARTDGTVAIFEVDRVGRYDKEALPADEVFGDFSRPQLRLITCGGRWVGGETGYADNVIVFASLVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6F9</accession>
    <name>F4F6F9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731776.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09935"/>
    <dbReference type="EnsemblBacteria" id="AEB43105">
        <property type="protein sequence ID" value="AEB43105"/>
        <property type="gene ID" value="VAB18032_09935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09935"/>
    <dbReference type="eggNOG" id="COG3468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_733392_0_0_11"/>
    <dbReference type="OMA" id="DCVPGFW"/>
    <dbReference type="OrthoDB" id="1280717at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="385" mass="41510" checksum="8C2C3B3C79C57D2C" modified="2011-06-28" version="1">MARTDSTGSTWRYRWARRQNERRLRLFRSAERAWRRRDDELRRLRTLAEQCHGSAAAGEGLLLELGPDEIVLRVVPAAQLVEVRHTAVLPAPELTVGVEHGRLHRRLPDGVRVTDAGMAVITNRRLVLLGGRGRRDWAYGRISGLAHDPQAPVSLIQVLDRRRTSGVLVPADAAAEFRFLLTLAFADAIEQRDAVIAQLDELIAEHTKARPSRPGIATPAQARLLALLPGGRRTAVVAAALAVLVPLALANSGPSDPTGRETAVAATPAPVAATVAPKAPRATGSPQALRVTGPKTPRASGSPTADRSSPQRRCGAPANPMGYDFCSGERIREPDPQVCEHFDCVPGFWEGRGYLVQCTNGKISLAGGSPRACGLHGGVRRTVWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6S6</accession>
    <name>F4F6S6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_22505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22505"/>
    <dbReference type="EnsemblBacteria" id="AEB45601">
        <property type="protein sequence ID" value="AEB45601"/>
        <property type="gene ID" value="VAB18032_22505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22505"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_1_1_11"/>
    <dbReference type="OMA" id="PYIYTPV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="33"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="377" mass="40425" checksum="E363440654CDCF56" modified="2011-06-28" version="1">MFMSGPAAGIGSPRAAQSVAAGTSWLTVDRGVVSIALVYPMRGPAGMFGPSCELCAQLAVEEVNGRGGVLGRELRLVPVDGGAPPAEVAAEVEALVSVGAVQGVTGWHISSVRQAVAPRIAHRVPYVYTALYEGGERTEGVFLTSETPDAQLLPAMRVLATDVGVRRWFVVGNDYVWPRRTTQAAYRYAQRTGGRVVGHHFLPLETHDYAEVLRRIERSDADAVLMLLVGADAVRFNRAFARSGLDQRCLRLSTLMDENMLLASGVAGTRGLFSTAGFFAGLVTPENLDFHGAFARRFGLEAPPLGSLGESCYEGVMLLAALIAKAGTLDVRAVEASADVVSYDGPRGELRLRRRHVRQRIYLAEADGLDFTVVAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6W1</accession>
    <name>F4F6W1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter/signal transduction systems periplasmic component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734288.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22680"/>
    <dbReference type="EnsemblBacteria" id="AEB45636">
        <property type="protein sequence ID" value="AEB45636"/>
        <property type="gene ID" value="VAB18032_22680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22680"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_4_11"/>
    <dbReference type="OMA" id="GVKDDQY"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309128" evidence="3">
        <location>
            <begin position="24"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="46"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="38603" checksum="465F79152F2B21A6" modified="2011-06-28" version="1">MRWLRLAALLVLLVVAAVTVVRVVSVTGPPSRDQLRERAGLTGKQELLIGVKDDQPGVSQLLENGAFVGFDIEIAYMIAEDLGFDAPRVRFLPIESEDRARRQARTPDGRFVTVDLVIASYSITEDRRRQGVVFSAPYLQTEQSVVTRADSKLAPTTFADLAGRKVCTLATSTAEQNLAAAGAQAHGRNRISQCIQELYDGTIDAVTTDAAVLAGFVAPPLAEQAPPVKKLTNPKPLRHFDIGADGDELWGVNTGPDPAMRDLVNLSLEEARNGRNGKRWRTAFDRYFGYSQKYNDQQQVAVDQQPPPGPADKVEVRQWPWERSAWRHPNQPRPGLSAAAVRVRARRSSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6X6</accession>
    <name>F4F6X6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734303.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22755"/>
    <dbReference type="EnsemblBacteria" id="AEB45651">
        <property type="protein sequence ID" value="AEB45651"/>
        <property type="gene ID" value="VAB18032_22755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22755"/>
    <dbReference type="eggNOG" id="ENOG5031TDC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188865_0_0_11"/>
    <dbReference type="OMA" id="MLMWVWI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="82" mass="9212" checksum="8D2DEB3859BC437C" modified="2011-06-28" version="1">MLKWIVLALVLVPLVVLALAVRPLLARLPQLRRAAVRLQRRADEATALRVAAESLQQRAEGLQGRLETTQRRLAVIRARRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Z1</accession>
    <name>F4F6Z1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735504.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46855">
        <property type="protein sequence ID" value="AEB46855"/>
        <property type="gene ID" value="VAB18032_28921"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28921"/>
    <dbReference type="eggNOG" id="ENOG50335GU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160021_0_0_11"/>
    <dbReference type="OMA" id="KVTLECW"/>
    <dbReference type="OrthoDB" id="1785527at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="137" mass="15113" checksum="B4E43F2F2CFB540F" modified="2011-06-28" version="1">MSTNPATVAKCLRLNAGFSQADRNWIVEQFATLDARLATFDADATDLELSIKDREAKGQRVTLECRIAGWEKIVTTSSEQDLRAALNDVRDDLRRKLNDAKTRQEPRNNKHLRVAPPPAPGVPAEELTGAGATSDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F718</accession>
    <name>F4F718_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735531.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29056"/>
    <dbReference type="EnsemblBacteria" id="AEB46882">
        <property type="protein sequence ID" value="AEB46882"/>
        <property type="gene ID" value="VAB18032_29056"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29056"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_1_11"/>
    <dbReference type="OMA" id="FESDHAS"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="386" mass="42948" checksum="F65674369A1C8D7A" modified="2011-06-28" version="1">MVPYRIEVPQEALDDLDRRLAATRWPGEMPGAGWDRGAPVGYLRTLAEYWRAGYDWRAAEAELNRLPQFTTEIDGANIHYVHVRSPEPDATPMIITHGWPGSFVEYLDVIGPLTDPRAHGGSPEDAFHLVIPTLPGFGLSGPLREPGWSMPRVAGAWAQLMARLGYDRYVAQGGDFGSWVTVMLAGMDHEHVLGGHLNFLPTPAVTESELAQLTEAEQERLYQFWRTSGQLAGHLYIQSTRPQTLGYGLTDSPVGQLAWIVEKFKDWTDSAKVPEDAVDRDRMLTNVMLYWLTSTGASSAHFYYENAALLPIATTPPPELPPPPLPFGVAVFPYDVGQPIRRFAERGLPNIVQWSEYDRGGHFPAMEVPDLFVGDLRAFAAKIRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F738</accession>
    <name>F4F738_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_29156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29156"/>
    <dbReference type="EnsemblBacteria" id="AEB46902">
        <property type="protein sequence ID" value="AEB46902"/>
        <property type="gene ID" value="VAB18032_29156"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29156"/>
    <dbReference type="eggNOG" id="COG0722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_11"/>
    <dbReference type="OMA" id="DINTGLR"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="48"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="369" mass="39053" checksum="F94D0D93534E3BFD" modified="2011-06-28" version="1">MTTPDNRRVIDQRIDRVVPLTTPALLHHELPLEDDLASAVVAGRRTAAQVLDRIDDRLLVVVGPCSVHDPAAALEYAHRLREAADRVADDLLVVMRVYFEKPRSTVGWKGLINDPGLDGSGDVNAGLRLARALLLDVLRLGLPVGCEFLDPITPQYIADTVAWGAIGARTVESQVHRQLASGLSMPIGMKNRPDGSIATAVDAIRAAGVPHVFPGIDVSGTPAIMHTRGNADGHLVLRGGGGRPNYDAASVAGALELLRAAGLPERLVVDASHANSGKDHRNQPAVVADVAGQIAAGQRGIVGIMLESFLVPGRQDLDPTRELTYGQSITDACIGWDTTDEVLTELAAAVRARRATRSSADPHSLPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F747</accession>
    <name>F4F747_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nlp/p60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_29201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735560.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="C40.007"/>
    <dbReference type="EnsemblBacteria" id="AEB46911">
        <property type="protein sequence ID" value="AEB46911"/>
        <property type="gene ID" value="VAB18032_29201"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29201"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034085_1_0_11"/>
    <dbReference type="OMA" id="QVIHAPY"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307467" evidence="4">
        <location>
            <begin position="30"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="209"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="35250" checksum="332DDB66FF5477F4" modified="2011-06-28" version="1">MSPLLHTLRALTVTAFALVLIAPATVARAEPSPAELTRRIDKASTELENVVEAHNELREKIKKNQAAVARLQERIGPLERQAAQSRADVSELAATAYKTGNLGAVDALLHGGDSASVLDRLGTLDHLTRQRQATIAGYTADQRRLLDEKTRLDVTLTQQAARSRELSTAKRRIERDLAKLYELRRQAYGRAAERPNNRPDSANDAPAVSGQAGVAVRYAYGALGKPYAWGQDGPNGYDCSGLTSAAWRAAGRSLPHNTRMQWGVVAHISRSELRPGDLVFYRSLGHVAIYVGGGQVIHAPTFGRNVEKRAVDLMTPYGYGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F786</accession>
    <name>F4F786_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin resistance abc transporter atpase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10130"/>
    <dbReference type="EnsemblBacteria" id="AEB43144">
        <property type="protein sequence ID" value="AEB43144"/>
        <property type="gene ID" value="VAB18032_10130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10130"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="ITAPMAD"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="337" mass="35122" checksum="5FCEF5D0F1B41AFA" modified="2011-06-28" version="1">MSRRATGLAIEAAGLTKSFGETHALAGLDLAVPAGAVYGLLGPNGAGKTTAVRVLATLLRPDGGQARVFGHDVVGEADAVRARVSLTGQYASVDEDLTGTENLVLLGRLLGLGKAAARARAEQLLEAFGLTEAAGRQVKKYSGGMRRRIDIAASILSTPDLLFLDEPTTGLDPRSRNQVWEIVRAVVAHGTTVLLTTQYLDEADKLASRIAVVDHGRVIAEGTPGELKSSVGSGTIHLRLRDAAKRPDAEQLLRTTLNVPVQLDPDPVAITARVGGDGSDLDAGAQAARALGELSRAGIVVDDFSLGQPSLDEVFLALTDRPAVPAEAEPEALEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7C8</accession>
    <name>F4F7C8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10340"/>
    <dbReference type="EnsemblBacteria" id="AEB43186">
        <property type="protein sequence ID" value="AEB43186"/>
        <property type="gene ID" value="VAB18032_10340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10340"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_2_11"/>
    <dbReference type="OMA" id="DFVDSWP"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="20190" checksum="9C208FC2CC3C047A" modified="2011-06-28" version="1">MANALIIVDVQKDFCEGGSLAVAGGAGVAAGISRLLASEPHRWDHVVATKDYHVDPGAHFGDPPDFVSTWPQHCVVGTPGSEFHPELATDRVEAIFHKGEYAAAYSGFEGHAGDGETLADWLRRHQVDSVDVVGIATDHCVRATALDAAQEGFATTVLLDLTAAVAPDTLDVALRAFEGAGITTHGTPVIRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7E0</accession>
    <name>F4F7E0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 6">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_10400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731869.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10400"/>
    <dbReference type="EnsemblBacteria" id="AEB43198">
        <property type="protein sequence ID" value="AEB43198"/>
        <property type="gene ID" value="VAB18032_10400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10400"/>
    <dbReference type="eggNOG" id="COG2986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014801_4_0_11"/>
    <dbReference type="OMA" id="CAPQVAG"/>
    <dbReference type="OrthoDB" id="715502at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="511" mass="53043" checksum="A3D1CA9FE6DA8662" modified="2011-06-28" version="1">MTVTIQPTGICPADVLAVARGTAKVVLDPATLDAMATSRSIVDGIEAAGRPVYGVSTGFGALANTFVAPERRAELQHALIRSHAAGVGAPMPREVVRAMMLLRVRSLALGHSGVRPLVASALVDLLNHDVTPWVPEHGSLGASGDLAPLAHCALVLLGEGWVLGPDGQRLPAADVLRQAGLAPIELAAKEGLALINGTDGMLGMLLLAIDDAAHLFTMADVTAALAIEAMLGSDRPFLPELHAIRPHPGQGRSAANIHRLLQNSAVMDSHRDDVDHAVQDAYSMRCAPQVAGAARDTLDFVRTVAGRELLSVVDNPVVLPDGRVESTGNFHGAPLGFAADFLAIAAAEVGAIAERRVDRLLDVTRSRDLPAFLSPDAGVNSGLMIAQYTAAGIVAENRRLAAPASVDSLPTSGMQEDHVSMGWAAAKKLRTVLDNLTSLLAVELLAAVRGLQLRAPLTPSPAGRAAIAALGEIAGEPGPDVFLAPVMEAAREVVATPTLRTTIEQAVGTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7J6</accession>
    <name>F4F7J6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="6" type="ordered locus">VAB18032_16655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733095.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16655"/>
    <dbReference type="EnsemblBacteria" id="AEB44435">
        <property type="protein sequence ID" value="AEB44435"/>
        <property type="gene ID" value="VAB18032_16655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16655"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_3_1_11"/>
    <dbReference type="OMA" id="FEPNLHT"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="78" mass="9065" checksum="590281A7498DC168" modified="2011-06-28" version="1">MSRRCDVTGAKPSFGNAVSHSHRRTRRRWNPNLQNHRYWLPSERRWVSLTLTAKALKTVDRKGIEKVVAELRARGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Q8</accession>
    <name>F4F7Q8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734347.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22975"/>
    <dbReference type="EnsemblBacteria" id="AEB45695">
        <property type="protein sequence ID" value="AEB45695"/>
        <property type="gene ID" value="VAB18032_22975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22975"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_5_0_11"/>
    <dbReference type="OMA" id="VCWAAEA"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="350" mass="37729" checksum="EB8FE3821D9ED2A5" modified="2011-06-28" version="1">MRLGLSLGYQTAWSTPADHLALAQEADRLGYSVVWAAEAYGSDSPSMLAWMAGQTERIDIGSAVMQIPARTPAMTAMTAATIDTLSGGRFRLGLGVSGPQVSEGWHGVRFGKPLARTREYVDIVKLAVARKEVSYDGQFYTLPLPDGPGKALRLGFHPPREHIPIYLAAVGPKNLELAGEIADGWLAIFYAPEYAQEQLASVTAGRARAGKELAGFDVVPSVPVVVGDDVASCAELVRWYAALYVGGMGSREQNFYNQLATRMGYGDAAREVQDLYLAKRQRDAAAAVPLEFIDRTSLLGPKERIAERMREYAEAGVTTLSVTLFVADRDSGVQTLRTVAEALELSGVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Y7</accession>
    <name>F4F7Y7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_29456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29456"/>
    <dbReference type="EnsemblBacteria" id="AEB46962">
        <property type="protein sequence ID" value="AEB46962"/>
        <property type="gene ID" value="VAB18032_29456"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29456"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_6_0_11"/>
    <dbReference type="OMA" id="YLQFEAY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="425" mass="44675" checksum="FA23AED1F6163850" modified="2011-06-28" version="1">MAHDGPHRSGPEQPGPEQSKPNQRDGPQQSRPDQQDGPQRQAAEPTAAAPQPQPPASTGTPPEQPAAPAPGSAGGDAGRFGIPGRPLRRNSFLVGFTGALGVLSAYAVYLGLRNAAGILVLVVIALFLAVGLHPAVVRLCAWGLPRGLAVAAVTLTVLALLAAGVLALVPPIVTQSGQFLDQLPSYLDTLRRNEAVNDLVVRFDLMRRAQEAANADVVGRALGGVLGGAQLVFGTVFRVLTVLVLTIYFLVYFDRMRELGYALVPRSRRERVQLIGDEILTKVGAYMVGALSIAVLAGVTTFVFALIVGLPYPFALAVVVAVTDLIPQIGATLGAVIVSLVGFATDPSVGIACVVFFVVYQQIENYLIYPKIMRRSVHVNEVAALVAALLGVSLLGVIGALIAIPTVAATQLILREVVLPRQDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F801</accession>
    <name>F4F801_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_29526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735624.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29526"/>
    <dbReference type="EnsemblBacteria" id="AEB46976">
        <property type="protein sequence ID" value="AEB46976"/>
        <property type="gene ID" value="VAB18032_29526"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29526"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_11"/>
    <dbReference type="OMA" id="CKLGFGH"/>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="186"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="29995" checksum="1420817C0C43A37D" modified="2011-06-28" version="1">MAGRLAVVGAGLMGSGIAQVAAQAGWQVTLRDLDDAATQRGVDGIRKSLTRFAEKGKISADEVEATLGRITPTTDLEAAADADIVVEAVFEQLEIKHEVFRALDRICKSDAILATNTSAIPVTQIAAVTERPEAVVGTHFFSPVPMMKLCELVRGYKTSDATLEAVKSFAEEIGKTVVVVNRDIAGFVTTRLICALAMEAVRLVEAGVISAEDLDTACKLGFGHAMGPLATVDLTGVDVLLNATRNIYTDTADEKFFPPELLQRMATAGDLGRKSGQGFYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F878</accession>
    <name>F4F878_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent dipeptidase microsomal dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10605"/>
    <dbReference type="EnsemblBacteria" id="AEB43239">
        <property type="protein sequence ID" value="AEB43239"/>
        <property type="gene ID" value="VAB18032_10605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10605"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_2_1_11"/>
    <dbReference type="OMA" id="WMRNGRW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="400" mass="44273" checksum="E366C9395372B10F" modified="2011-06-28" version="1">MLLDPAPRYQGHRSYSYLEPHSDYRVFTLAKEVGRVPEHDLGLTDAQRARVTRLLTEHTAISLHEHPVILPEDVRELRAYNRTARQRTGYEGLARSGLTAVFDNFMAGASCVTSENGWKWNDLIYALGMRMSDLYKQDHVFLATSLADIHAAKRDGRLALVAGLECSSPIENELDRIDILYGFGVRQLGIAYSQANMLGGGLSEKHDGGLTHFGRRAVDRMNKLGIAIDISHSGDQTCLDVIEASRVPVFITHAGARAVWDTSRMKPDEVIRACAERGGVIGIEAAPHTTLSEAHKHHSIESVMDHFTYCVDLVGIDHVTFGPDTMFGDHVGVHNTYAGNYAHDAGNRPEHPRVEYVSGVENPGEAFGNIVGWLVKHDYSDDEIAKVIGGNTIRVLEQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8B7</accession>
    <name>F4F8B7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, PaaX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10800"/>
    <dbReference type="EnsemblBacteria" id="AEB43278">
        <property type="protein sequence ID" value="AEB43278"/>
        <property type="gene ID" value="VAB18032_10800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10800"/>
    <dbReference type="eggNOG" id="COG3327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067515_1_0_11"/>
    <dbReference type="OMA" id="WDGTWTL"/>
    <dbReference type="OrthoDB" id="1210594at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="2">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="3">
        <location>
            <begin position="173"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="32357" checksum="99A965D6B249A944" modified="2011-06-28" version="1">MRSRQPKQLLLAFFGEHVVDAATGPIRASALISVLEPAGVAAPATRATLDRLVGSGILARTRNGRETLFSLTEHGAAVLREATDRVRGPRPFDPQGNGWTLVTFSIPEGQRMLRHRLRSTLTWEGFAPIRDGLWLAPGEVDLAGSLEPLRQDLPPHTVMAFHARELDGFPIGESVRAAWDIEAIRREHLAFIEVWDDPAAVALAPSALTVRTMLVADWLALLRADPRLPAEFMDEQWPATRSAETYRRMHEKLAEASAAEFAELVAARTSVRRRNGRAGPPSAPSPTPSAATRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8C5</accession>
    <name>F4F8C5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16830"/>
    <dbReference type="EnsemblBacteria" id="AEB44470">
        <property type="protein sequence ID" value="AEB44470"/>
        <property type="gene ID" value="VAB18032_16830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16830"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053651_0_0_11"/>
    <dbReference type="OMA" id="FTLAHYY"/>
    <dbReference type="OrthoDB" id="1840229at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="363" mass="39914" checksum="E10E46530BA0A0EF" modified="2011-06-28" version="1">MADGWDWPLVGEQVRQARLSLGISQQDLATMVGLDRTMLAKVEAGSRRLDALELAKLSRALKVSMEYLIQPPPTVLSRRAAPLTEETDTEAARSSERLEIALVEWLHNVQQLLDIGVLRARPLLRYPHSVTSEDDARQTARWLRQRFDLGDGPIDSIMDVCERAGQWVLVTDLPGDGASLIEGDIAVAVVSTTGDPGRRRATAAHELGHLIIGDEYSADLGLSASRAQRETVIDAFAAELLLPVQAIAAARGTVGRDQIVSYAARYRTSWLLALRQAEQAGAIDAETRRAWSQVRPTHAEFMEAVGWVPQPDLESVRVSPTYAKAVMGALRNRRITRTRALELMNGHIAEADLPQDDDLEIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8I4</accession>
    <name>F4F8I4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17125"/>
    <dbReference type="EnsemblBacteria" id="AEB44529">
        <property type="protein sequence ID" value="AEB44529"/>
        <property type="gene ID" value="VAB18032_17125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17125"/>
    <dbReference type="HOGENOM" id="CLU_2371938_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="95" mass="10044" checksum="DE79627888375AD0" modified="2011-06-28" version="1">MVLFGDRTGDDAGDVFADVLGSLFLRRFIEFVEGVEFPFEGAPLGVVLHQVQCSLAERKVLGFMAAAHSPSLAIAGKELDGQSRAAMACTSTAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8V4</accession>
    <name>F4F8V4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snare associated golgi protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735682.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29816"/>
    <dbReference type="EnsemblBacteria" id="AEB47034">
        <property type="protein sequence ID" value="AEB47034"/>
        <property type="gene ID" value="VAB18032_29816"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29816"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_1_1_11"/>
    <dbReference type="OMA" id="IYLAYKV"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="219" mass="23873" checksum="2CE112A72E5FCF1D" modified="2011-06-28" version="1">MALAQDVDPSQVGGLTGWVAGVIEAAGPLGVALLVALESIIPPIPSEIVLALAGYLAGEGRFNVVVVTVAATVGSVLGALVLYWLGAAVGEDRLKRWLDRLPLVDLDDLEKADRWFERYGRWAVFFGRMAPVVRSLVSIPAGANRMPLVEFVTLTTLGSALWNGLFIGLGYALGTRWNQIDRYSSWFDYGILAILALMLATWALKKHRRRTHPRTPTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9P4</accession>
    <name>F4F9P4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_17600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733277.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17600"/>
    <dbReference type="EnsemblBacteria" id="AEB44622">
        <property type="protein sequence ID" value="AEB44622"/>
        <property type="gene ID" value="VAB18032_17600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17600"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_0_3_11"/>
    <dbReference type="OMA" id="FEIETSR"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="67" mass="7197" checksum="DD7B5E5F4A72314A" modified="2011-06-28" version="1">MATGTVKWFNGDKGFGFISQDDGGADVFAHFSAISASGFRSLDENQRVQFEITQGPKGPQASDIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9P9</accession>
    <name>F4F9P9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_34 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23635"/>
    <dbReference type="EnsemblBacteria" id="AEB45825">
        <property type="protein sequence ID" value="AEB45825"/>
        <property type="gene ID" value="VAB18032_23635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23635"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142189_0_2_11"/>
    <dbReference type="OMA" id="LRLAIMS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="2">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="13172" checksum="7C2314732FC84062" modified="2011-06-28" version="1">MTEPSSGAPDAGSSPHPATTLDDVVHQRVRLGILTVLSEATECRFATLRDELGLTDGNLNRHLRILEQAGLLQATKGYEGRRPVTWLRLTRAGRTALRAEVAALEQLVSRIRTATVADEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Z8</accession>
    <name>F4F9Z8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00125"/>
    <dbReference type="EnsemblBacteria" id="AEB47109">
        <property type="protein sequence ID" value="AEB47109"/>
        <property type="gene ID" value="VAB18032_00125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00125"/>
    <dbReference type="eggNOG" id="ENOG5032Z35">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200516_1_0_11"/>
    <dbReference type="OMA" id="GEFYCVK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="1">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="55" mass="6044" checksum="EFBB075388F15D6D" modified="2011-06-28" version="1">MADQAQTYNGYCVKCKEKRDFEGRVEVSKTGMNMAKGKCPVCGTTVNRILGKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA00</accession>
    <name>F4FA00_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735757.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00135"/>
    <dbReference type="EnsemblBacteria" id="AEB47111">
        <property type="protein sequence ID" value="AEB47111"/>
        <property type="gene ID" value="VAB18032_00135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00135"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_9_3_11"/>
    <dbReference type="OMA" id="WGLGKRI"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="93"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="442" mass="47980" checksum="5A0B2688040DCEA3" modified="2011-06-28" version="1">MTDIPRRAVSRTAKLAALPLGFAGRTVLGMGKRVTGLASDVISAEIQQRTAEQLFSVLGQLKGGAMKFGQALSVFEAALPEEVAAPYRQALTKLQEAAPPLPAASVHRVLAEQLGPAWRDRFDSFNDSPAAAASIGQVHRAVWRMPDDTTRDVAVKIQYPGAGDALLADLKQLSRLGGMFRAIQPGLDIKPLLTELRERITEELDYELEAESQRAFATAYADDSEIYVPTVFSASPRVLVTEWVEGTPLADIIRDGSEQQRDEAGRLMATLHLSAPMRAGLLHADPHPGNFRLLPDGRLAVIDFGAVARMPEGTPEPIGRIAGLALRGDADKVVAGLRAEGFVSADAPVDGQALLDFLRPMLEPIATDEFRFTRAWLRAEAARLANPRSPAYQFSRQLNLPPSYLLIHRVTLGSIGVLCQLEARAPYRGIMERWLPGFAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA01</accession>
    <name>F4FA01_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47112">
        <property type="protein sequence ID" value="AEB47112"/>
        <property type="gene ID" value="VAB18032_00140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00140"/>
    <dbReference type="HOGENOM" id="CLU_3349991_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="37" mass="4005" checksum="32B6CAA5DA93CE86" modified="2011-06-28" version="1">MLRPQAGRTTTSTEATRSARTVAMASRNRSARELGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA18</accession>
    <name>F4FA18_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735775.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00225"/>
    <dbReference type="EnsemblBacteria" id="AEB47129">
        <property type="protein sequence ID" value="AEB47129"/>
        <property type="gene ID" value="VAB18032_00225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00225"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_4_0_11"/>
    <dbReference type="OMA" id="HQKPIGL"/>
    <dbReference type="OrthoDB" id="1255127at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="19239" checksum="DDAC6D9A87B947DC" modified="2011-06-28" version="1">MAAICVFCASSRTLDQRWLDLATATGAEIARRGHTLVSGGGCVGMMGALVDGARSAGGRTIGVIPQALVDLEVADLASDELVVTDSMASRKVVMIEKSDAFLTLPGGLGTLDELFEVWTTATLALHRKPMVLVDTDGFYSPLVEWLRNVTAQNFLKPGGFNLLQFADTLPAALDLLESRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA86</accession>
    <name>F4FA86_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05105"/>
    <dbReference type="EnsemblBacteria" id="AEB42147">
        <property type="protein sequence ID" value="AEB42147"/>
        <property type="gene ID" value="VAB18032_05105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05105"/>
    <dbReference type="eggNOG" id="ENOG50309VF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775709_0_0_11"/>
    <dbReference type="OMA" id="IGDIRRP"/>
    <dbReference type="OrthoDB" id="2058061at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="365" mass="39529" checksum="607CF461D16EF52D" modified="2011-06-28" version="1">MAMAALVPTLAGCSIGDIRRPPPTPTPVPSSAAPSSPPQIAEVRGSRLAVPRQYDRPYVEFVDAYRGYALFGSCDGQPPGRNCPALLWSTGDGGRSWQRLRHPKPVADNQQMYTAPGLLALWAEPYGWWTSTDDGRTFRHSPGEVAPPQWRATQGRFQISEKTGKVGRWTGRTLRPLATQPPLPALNAVVLGDAWLVRNGTRYEGPLVAAGAGEDGRPYAAISWDEGRSWEPTTLPAPDGEVWLLRVESVAGELWLIGERPDRISFPALWRLEGASWQRVRAEGQPGAGRAVPLGAGVVAVVSSRGAGALLGGRYVDLPRWPLTDRHHLRRLPDGTLFAGTSETILLGIGHLGDRTWVEVALETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAC3</accession>
    <name>F4FAC3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05290"/>
    <dbReference type="EnsemblBacteria" id="AEB42184">
        <property type="protein sequence ID" value="AEB42184"/>
        <property type="gene ID" value="VAB18032_05290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05290"/>
    <dbReference type="eggNOG" id="ENOG502Z9FH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064457_0_0_11"/>
    <dbReference type="OMA" id="QIMFGAI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="316" mass="34703" checksum="B19066F4BC4A24B8" modified="2011-06-28" version="1">MWSTDVYDAADRYRRATGTSAFAYSDSGARKVHPALDPRDSVRESRDSAEHPQSTPVAVLFDVTGSMGHVPRTLQAKLPQLLGLLLRQGYARDPQIMFGAIGDATCDRVPLQVGQFESDNRMDDDLGRIVLEGGGGGQMMESYELALYFMARHTVTDSWEKRGRRGYLFIIGDELAYSKVKSAEVSRWIGGDLRKDMPVQQIVDEVTRRWDTYYLLPAGSHYAGNRKVLDFWRGLLGQNALELDDLDAVCETIALTVGLGEQAIDLDTGLRDLDRAGSTATGTVSKALARIGNTGRRTETSRLPATGTGRGGVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAD9</accession>
    <name>F4FAD9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732037.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11240"/>
    <dbReference type="EnsemblBacteria" id="AEB43366">
        <property type="protein sequence ID" value="AEB43366"/>
        <property type="gene ID" value="VAB18032_11240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11240"/>
    <dbReference type="eggNOG" id="COG3861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136247_0_0_11"/>
    <dbReference type="OMA" id="FTPWTWR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="16461" checksum="AC8427DB04CCB347" modified="2011-06-28" version="1">MDRLDPNTTNATPDPALRAVDRDVVTTGGATNAFDPWSYRDEAGVAGTNLIGYKVEATDGSIGKIDSDSSEVNASYLVVDTGPWIFGKKVMLPAGTVNHVDHDEQKVYVDRSKDQIKAAPEYDDTINDPSYRDKLGGYYNDTYAATPPGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAG4</accession>
    <name>F4FAG4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rok family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11375"/>
    <dbReference type="EnsemblBacteria" id="AEB43391">
        <property type="protein sequence ID" value="AEB43391"/>
        <property type="gene ID" value="VAB18032_11375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11375"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_11"/>
    <dbReference type="OMA" id="LPYWLTR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="35681" checksum="9415DD93BAFA0A12" modified="2011-06-28" version="1">MVVGIDNGGTSNNATVLTLDGRFLVDQLVETPSEVRAGPQAAVEAMARSFDGVLALTGLSRDQVRAVGLDTPGPASATGVISSKGSTNFSQPAWRGHDIRGALERRLGLPVIYHNDGNAAALYAHHVHFGVDAMHRSSVSAIVGTGLGGGLVEYGRVIAGAAGMAGELGHVHVPLTDVLAPGQPVPVCACGFAGDVESIASLTAIERNLLPYWLTRFPDHPLAGEPPALAAKLVRGYGERGDEMAREVFAQQARALGALFTIAANFTDPHAYFVGGGVVETAPEFRDWFLATVREHTVLRDEQAASATFALVPERDMAGARGAALAALAAARELPVPPPLVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAL3</accession>
    <name>F4FAL3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_17630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733283.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17630"/>
    <dbReference type="EnsemblBacteria" id="AEB44628">
        <property type="protein sequence ID" value="AEB44628"/>
        <property type="gene ID" value="VAB18032_17630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17630"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_9_2_11"/>
    <dbReference type="OMA" id="AWVHFPE"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="112"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="218"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="385" mass="42147" checksum="DC416F420F5D2512" modified="2011-06-28" version="1">MSDHTAHGLRALVAAFLDTHDPDGDRLGFLRARFDAGLAWVQHPPGRGGLGAPPQLQAVVDDAFAAAGAPDNRPRRNSIGLGMAAPTLLRHASDAQCRRWLRPLWTGEEVWCQLFSEPDAGSDLASLRTRAVPDDDDWIIDGQKVWTSLAHEARWAILLARTDPAAPKHHGITYFVCDMTAPGVQVRPLRQATGEAEFNEVFLTGVRVPDAHRVGAVGQGWQIARTTLMNERVAIGGRPLPREGGMVGVLARLWRERPELRTAGLHDEVLRAWVGAEAARLAALRLRQLIAAGEPGPEGSAVKLSFAELSQRISGLEVELRGAEGLRHDDWTMRRPTEPDLLGRTATYRYLRARGNSIEGGTSEILRSIIAERVLGLPTEPRVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAM1</accession>
    <name>F4FAM1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17670"/>
    <dbReference type="EnsemblBacteria" id="AEB44636">
        <property type="protein sequence ID" value="AEB44636"/>
        <property type="gene ID" value="VAB18032_17670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17670"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007526_0_0_11"/>
    <dbReference type="OMA" id="AYQCMQL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="55"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="37962" checksum="D7AEC5082B944E90" modified="2011-06-28" version="1">MPDPADHATSDDATPDDAASDDGGPLPGLDLDRLATYLHRQVPGLLAGPLHGALLTGGRSNLTYAVTDGQTRWVLRRPPLGHVLATAHDMGREYRVMHALAPTAVPVPPMVHHCADPTVLGVPFYLMGQVPGRVHREPEELVGWSPSQVRDLAFRLIDLLAVLHTVEPASVGLADFGRPDGFNARQVRRWKRQLDASRSRDLPGIGDLHDRLAAAVPETRSAAVLHGDFRLDNVLLGEDRTVRAVLDWEMSTLGDPLADLALSLVYARRVTAPGQPDTDELADRYARRTGRSVDALPWYLAFAAFKLAVILEGVHYRYVQGQTVGDGFDQIGARVPPLIAEGLSTLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAU5</accession>
    <name>F4FAU5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secreted pectate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_24050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734560.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24050"/>
    <dbReference type="EnsemblBacteria" id="AEB45908">
        <property type="protein sequence ID" value="AEB45908"/>
        <property type="gene ID" value="VAB18032_24050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24050"/>
    <dbReference type="eggNOG" id="COG3866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_2_1_11"/>
    <dbReference type="OMA" id="DNTQYVT"/>
    <dbReference type="OrthoDB" id="660314at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PTHR31683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307573" evidence="4">
        <location>
            <begin position="34"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Amb_all" evidence="5">
        <location>
            <begin position="78"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="522" mass="53987" checksum="9740F7F9E16392BF" modified="2011-06-28" version="1">MRRTVALRVLAALATTATGAAVCVAVMTPQASAAVGSATGFATRNGGTTGGAGGQTVRATTGTQIHAALCNRASSSTPITIQVEGTINHGNTTKVSGSSCNTAADVIELKQISNVTILGVGNGATFDQIGIHIREASNIIIQNVTVRNVKKSGSPTSNGGDAIGMEANVRNVWVDHVTLEASGGESQGFDGLFDMKNNTQYVTLSYSILRNSGRGGLIGSSESDLSNGFVTFHHNLYENIDSRAPLLRGGVAHIFNSHFSRINESGINSRAGAQAKVENNYFQNAKDVLGTFYTDQAGYWQVSGNIFDNVTWSSRSGDTNPAGPNPTSNTSVSIPYSYRLDPANCVPDIVRQTAGANKGIRTSNGSCTPTNPTSNPTTPTPGPTTPTPGPTSPTPTPSQPSGTNLSIGAGSDGSSKASGTSYGDVRDGNMSTAWSPSGSTGQISIKWDTATRVSRVNIREASGAVGNVRSWRLLNHDTGAVLATGSTAGVITFPATSLRKITFDITSSSGTPRIAEFETYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB01</accession>
    <name>F4FB01_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate-binding CenC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_24330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734616.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24330"/>
    <dbReference type="EnsemblBacteria" id="AEB45964">
        <property type="protein sequence ID" value="AEB45964"/>
        <property type="gene ID" value="VAB18032_24330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24330"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016001_0_0_11"/>
    <dbReference type="OMA" id="NINNGEW"/>
    <dbReference type="OrthoDB" id="386120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309206" evidence="3">
        <location>
            <begin position="35"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="571"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="803" mass="84559" checksum="7456C06B1E6D0F65" modified="2011-06-28" version="1">MTSHLRRATRRRVTAIAAAGLLLAGFVSAAPVQAADTNLIVNGGFEEGLTGWFVNNGNSTDAATLTPTSDAYSGATAVHVTNRATTGSGPMQDLSGKVQAGQTYALSARIKYDNPQSPGTKQFFATMHYGGGTYTNLVSVTATRGQWAHFNGQFTIPASQGVSTARLFFETPWTSNPASDPNLHLMDFTLDDVSVVGAPPPPPASKTIEVVGKLPGEHNPLIGHKFGADGYGFVHDGRVYMYMTNDTQGYAPNPTTGVSPGINYGDINQITVISTTDMVNWTDHGEVQVAGPNGVAPFTSNSWAPGMAKKVVNGQEKFFLYYANNGSSSNVITGASPIGPWTSERTSTLIDGRTPGAEAVAWKFDPAPFVDEDGEPYLYFGGGPASTSMPAAERFNNPKNLRAIKLGDDMVSTEGTAAVVDAPVAFEAAQVFKRDGKYYLSYSSHFGGSDFGGNQTPLPGYPGGGQIGYMISDDPMSWPKETYAGVLFPNQSQFFGSGTGGNNHQSVFEYEGKYYFTYHAPTLNKRINGNTTQGYRSPHIQELAFNADGTIQQVVGTYAGVEQVRDFDPYRVFEAETFGWSKGIATAKVDGGSAEFGGSAPNLIVRDIDNGDWTALSSVNFGAGAGTVTAKVRPLAAGGQIQVRLDEVGGPVVATIAVDGTIGEWTELSAQLDGVAGVHDVYFTYSGPAGADLFELDTWQFTAAAAELPVTATAQTRCIGGTVYLAVQARNDHDGPVAIELETAYGKRSLSAVAAGANAFQQFNTRTATLAAGTATVRVTGSIDGRTVTTTHTVNHPGATCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB79</accession>
    <name>F4FB79_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735869.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00700"/>
    <dbReference type="EnsemblBacteria" id="AEB47224">
        <property type="protein sequence ID" value="AEB47224"/>
        <property type="gene ID" value="VAB18032_00700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00700"/>
    <dbReference type="eggNOG" id="ENOG5032U9K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122324_1_0_11"/>
    <dbReference type="OMA" id="PDHYVTW"/>
    <dbReference type="OrthoDB" id="1745545at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035165">
        <property type="entry name" value="DUF5319"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17252">
        <property type="entry name" value="DUF5319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="15578" checksum="47836CAD599E0AFE" modified="2011-06-28" version="1">MQDEPIDPFTGDPADPAAGLDDPDRDSSLDPLTDVERQDVLEDLADLEIYQALLAPIGVRGLVIECEDCREPHYFDWDLLRGNLRHLLSSGRPRVHEPAFDPDPDHYVTWDYARGYADGVHDTLSEGTEDSEDEAASRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBC9</accession>
    <name>F4FBC9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly-gamma-glutamate synthesis protein PgsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730898.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05495"/>
    <dbReference type="EnsemblBacteria" id="AEB42225">
        <property type="protein sequence ID" value="AEB42225"/>
        <property type="gene ID" value="VAB18032_05495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05495"/>
    <dbReference type="eggNOG" id="ENOG50333YX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143404_1_0_11"/>
    <dbReference type="OMA" id="CITYVIL"/>
    <dbReference type="OrthoDB" id="1730371at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008338">
        <property type="entry name" value="Capsule_biosynth_CapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14102">
        <property type="entry name" value="Caps_synth_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="161" mass="17139" checksum="9AC8C6C1A128D823" modified="2011-06-28" version="1">MIFGGELSAQLATACLGIGLVFALLCYLTTNLSPGGMITPGWIALALIEDPLQAGVIVVMTVVTYGLTRLMQRMVILYGKRLFAAIVLLSVFLQMTLFIIVQRDLPLLFAHQTLGFVAPGLIAYQLVRQPPKATVLATIMVTAITYGVAVSGIVAGFVPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBI4</accession>
    <name>F4FBI4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11660"/>
    <dbReference type="EnsemblBacteria" id="AEB43446">
        <property type="protein sequence ID" value="AEB43446"/>
        <property type="gene ID" value="VAB18032_11660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11660"/>
    <dbReference type="eggNOG" id="ENOG502ZNCM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860217_0_0_11"/>
    <dbReference type="OMA" id="YESDWRA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="331" mass="34677" checksum="9F87E0CBAEB9D68C" modified="2011-06-28" version="1">MDGRRSFADDHESGWYPGDRDHGYGDPDWRDTAQARYRDDTPVPPEQRIDDEDRYDTAARRFGGVDPLADIPAEPERYRASRARRAGSTDPDVSGELPTERPGRRAARETTAPVGADPLLNDPAPFAPVVSDPAPFASAVDEPAPLASVVGDPARSVPLTGYPIVEAKRGTEAMNPLEQPTGPMPPVAPRGDLAAGNTGDQQAAGDTGFRPTTGEGGYQVPGVPAGPPSGDGVYRTRRPVLAVLFAVLVVIFEVPALRVLLHGATADPVSAADVLVGTFLVAGLPIFAVGLYGLRTTGFSLADGARGWLRPPTAYLTVGLALFLAAALAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBM2</accession>
    <name>F4FBM2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_11850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732153.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11850"/>
    <dbReference type="EnsemblBacteria" id="AEB43484">
        <property type="protein sequence ID" value="AEB43484"/>
        <property type="gene ID" value="VAB18032_11850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11850"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764876_0_0_11"/>
    <dbReference type="OMA" id="VSTVHHW"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="370" mass="40889" checksum="8466EC6243B38683" modified="2011-06-28" version="1">MDELLTVGRVARLTGVSVRTLHHYDEVGLLVPSARTTSGHRAYSAEDVERLREVLAYRRLGFGLREIADLVGDPATDAVAHLRRLRGLLVDRQDRAAAMVAAIDRELAARAMGVTTPQVPLKAFGARLYDAIGSAYPATRRTEPRIAARVWAALGDARTVLNVGAGTGSYEPPDREVTAVEPSAVMRAQRPPGAAPCVAAAAESLPFEDQSFDAAMAFSTIHHWHDPIAGLREMRRVARRVVVFTHDASDTGWRHRFWLTRDYLPEVVDLVADRPSVDQVARAIGAHMEPVLIPWDCADGFFEAHWRRPEAYLDERVRGAVSVWARVGPQAQRRAVETLRDDLASGRWVERNREILALDAAELGLRLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBP7</accession>
    <name>F4FBP7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11975"/>
    <dbReference type="EnsemblBacteria" id="AEB43509">
        <property type="protein sequence ID" value="AEB43509"/>
        <property type="gene ID" value="VAB18032_11975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11975"/>
    <dbReference type="eggNOG" id="ENOG5031J2Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1874563_0_0_11"/>
    <dbReference type="OMA" id="VWWTLPV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="15013" checksum="6A0273ED24D1BBB7" modified="2011-06-28" version="1">MMEQPHDLTLDAPRTWERPVVSVPVLVALSLVGGRFPSFSTEANLYVFGAGGALIWLGLSNRVPRRPAPQRLSSGAVWWTLPVLVFGVFEGATFFSAAGEDFPTFSLLADPLLEDRLVRSAGWLVWLSAFWGLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBS5</accession>
    <name>F4FBS5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733380.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18115"/>
    <dbReference type="EnsemblBacteria" id="AEB44725">
        <property type="protein sequence ID" value="AEB44725"/>
        <property type="gene ID" value="VAB18032_18115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18115"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OMA" id="VGHHISL"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="299"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="389" mass="42123" checksum="C312EE2F2A662CE7" modified="2011-06-28" version="1">MARWSRTARHGLAGEIGPALVVLAVSLSATAIIGWQDGSPHPPLPFGYLLLTIDAALIALHRRWPLVMLAGTLALSLTYHGLNFPGGAFTIPPAVAIYFAVVSRHRLAAGLTALAFLAGVFLLGPLHDREPNTQGAVWLVAWLSLIMAVGEAARSHQERLRQVQERAALAEATREEEARRRAVEERMRIARELHDVLAHRISTVTIQAGVAAHLIDRDVDQAREALLAIRETSRGVLVEMRSTLGMLRRVDEDELPTDPVPGMADLDSLVRDAEANGVDVALDVVDVPAVLPASLDLALYRIVQESLTNVIRHSGAVRARVRIVHERGEVEVEVRDDGRGAPPEPFSQGNGLLGMRERVAAVNGTFEARGADDGGFVVSARMPLRSDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC89</accession>
    <name>F4FC89_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735912.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00920"/>
    <dbReference type="EnsemblBacteria" id="AEB47268">
        <property type="protein sequence ID" value="AEB47268"/>
        <property type="gene ID" value="VAB18032_00920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00920"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_6_2_11"/>
    <dbReference type="OMA" id="GWYEREH"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="316" mass="34335" checksum="4AA960E749E1F86B" modified="2011-06-28" version="1">MRVTVFTEPHRGASYDDQLRFARLAEEGGFEGFFRADHYQAMGDEPALPGPTDAWLTLAALARETSRIRLGTLVTSATFRLPGPLAVMVSQVDQMSGGRIELGIGAGWYAREHISYGIPFPSVTERFDRFAEQLEVISGLWATPSGESFSYAGKHYQLTDAPALPKPVQTPGPPIIVGGRGPRRTPELAARYADEFNVPFTSLEQTADAYERARQASERIGRADSGRAPLVLSAGIVVAVGRTDAEAARRAAPLHVKSALPPEDAVIGSPQQLVDRIGEFAAIGTERVHLRLIDLTDLDHLELIASEVLPRLEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC97</accession>
    <name>F4FC97_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine oxidase thio</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00960"/>
    <dbReference type="EnsemblBacteria" id="AEB47276">
        <property type="protein sequence ID" value="AEB47276"/>
        <property type="gene ID" value="VAB18032_00960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00960"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_5_11"/>
    <dbReference type="OMA" id="CRRLEPM"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012727">
        <property type="entry name" value="Gly_oxidase_ThiO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02352">
        <property type="entry name" value="thiamin_ThiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="3">
        <location>
            <begin position="2"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="358" mass="37462" checksum="70477F07E63F1F17" modified="2011-06-28" version="1">MGAGPIGLAIAWRCAARGLRVVVHDPAPGSGASHVAAGMLAPVAEAYFGEHELTGLLTESARRWPGFAAELTEATGVDIGYRTEGTLMVGLTADDLAEARRLWSYQQGLGLPVSLLRPSQLRAREPALAPRVRGGALAATDHQVDPRRLVPALRLAAARAGAVLVTEPVRQLSEPSGGVTVVAAGCGAAALTGLPVRPVKGQVLRLRTPDGGPPGFRHVIRGYADGEHVYLVPRECGEVVVGATVEERTDVAVSAGAVLRLLRAAVDLMPELAEYDLVETIAGLRPGTPDNAPILGPLPGRPDVLAATGHHRHGIVLTPVTADLITGLITGEGTDDPLLTPFRADRFHPDSKEEDLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCD2</accession>
    <name>F4FCD2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">rplV</name>
        <name evidence="13" type="ordered locus">VAB18032_01135</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01135"/>
    <dbReference type="EnsemblBacteria" id="AEB47311">
        <property type="protein sequence ID" value="AEB47311"/>
        <property type="gene ID" value="VAB18032_01135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01135"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_2_11"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="14178" checksum="EC602062B82999AD" modified="2011-06-28" version="1">MRISPMKARRVVNLVRGLPAKEALTVLQFAPQAASEQVYKVLASAIANAENNERLDPDALLVSEAFVDEGPTMKRFQPRAQGRAYRIRKRTCHITVAVEAVAPAAPKKSAKKAAPAAQSAPAETQSNTEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCD6</accession>
    <name>F4FCD6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplD</name>
        <name evidence="7" type="ordered locus">VAB18032_01155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735953.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01155"/>
    <dbReference type="EnsemblBacteria" id="AEB47315">
        <property type="protein sequence ID" value="AEB47315"/>
        <property type="gene ID" value="VAB18032_01155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01155"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_0_11"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="22975" checksum="6B119FE57C6FA54F" modified="2011-06-28" version="1">MTTVDVLNSEGTKTGSVELPGDIFDVQANVPLMHQVVVAQLAAARQGTHKTKTRGEVSGGGKKPYKQKGTGRARQGSIRAPQFAGGGVVHGPVPRDYSQRTPKKMKAAALRGALSDRARAGQVHVVEAFVSGEKPSTKAALAALTKVTEARRVLVVLSSVDELNWVSLRNEPRVHLIEAGQLNTYDVLVADDVVFTKEALDEFLGVPAETTEEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCJ6</accession>
    <name>F4FCJ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M14, carboxypeptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730996.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05985"/>
    <dbReference type="MEROPS" id="M14.007"/>
    <dbReference type="EnsemblBacteria" id="AEB42323">
        <property type="protein sequence ID" value="AEB42323"/>
        <property type="gene ID" value="VAB18032_05985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05985"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019326_3_0_11"/>
    <dbReference type="OMA" id="HQHAREH"/>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03859">
        <property type="entry name" value="M14_CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033810">
        <property type="entry name" value="Carboxypeptidase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307795" evidence="1">
        <location>
            <begin position="33"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="452"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="626" mass="66892" checksum="B3FF8C1E35C70805" modified="2011-06-28" version="1">MAFRSIPVRRTLAMIVAAGLGLLALSAPPVSARPAPDRDEQPAAAPYRVLGPRTLADRTAVARTGAAIDYSEHGVLHISATRAEAAAITRLGFTLEPIAAPPTDRGHDHGDVGALAFPPADANYHDYAEMVAVVNKVVADHPAIARKISIGTSYEGRDLVAIKISDNVATDENEPEILFNSQQHAREHLTVEMAIYLMNLFTDSYGTDSRITNLVNNREIWIVPSVNPDGSEYDIATGSYRSWRKNRQPNSGSSYVGTDLNRNWSYNWGCCGGSSSSTSSDTYRGPSAFSAPETQALRNFVNSRVVGGVQQIKANIDFHTYSELVLWPYGYTYNDTATGMNADQYNTFATIGRQMAATNNFTPQQSSDLYITDGSSIDWMWAVHGIWAYTFELYPRSASGGGFYPPDEVIPQQTSRNREAVLILAEYADCPYRAINKQAQYCGGGSGGTTVWSDTFETNTGWTINPNGTDTATSGQWERGAAQATNSSGAKQLTPYAGSNDLVTGRLAGSAAGDYDVDGGVTSARSPAITLPSSGTLTLSLAWYLAHGSNSSSADYFRVSVVHNGGTTTLLSQAGAASNRNGAWTTSNLNLTPYAGQSIRILVEAADASTASLVEAAVDNVTITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCT1</accession>
    <name>F4FCT1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732244.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12305"/>
    <dbReference type="EnsemblBacteria" id="AEB43575">
        <property type="protein sequence ID" value="AEB43575"/>
        <property type="gene ID" value="VAB18032_12305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12305"/>
    <dbReference type="eggNOG" id="ENOG5030VV3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1916197_0_0_11"/>
    <dbReference type="OrthoDB" id="2096612at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307804" evidence="1">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="14854" checksum="B0062DF7419A2FFD" modified="2011-06-28" version="1">MRVRQIIAAAMTGAAAVAIAAAPAQADRGDSKAACNKGEICFQWIYDNFSTSSYQRHFWYNDSNHGDDYWSNIPDLYPAFVIKDDAEGLWNRDTTCAVTIYDLANYVTPYTTFPRDFRAAISPRNNSHKRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD63</accession>
    <name>F4FD63_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24975"/>
    <dbReference type="EnsemblBacteria" id="AEB46093">
        <property type="protein sequence ID" value="AEB46093"/>
        <property type="gene ID" value="VAB18032_24975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24975"/>
    <dbReference type="HOGENOM" id="CLU_1694760_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="155" mass="16484" checksum="99BA6BB25A81F6BB" modified="2011-06-28" version="1">MRHHPEPTGRRCRPTNSTRPGRSRCGEHDDRCGTRRPAGGPYPPSAAPRVRFTPSAIPVLTCTPARHEAALRGAAEALARLGRSDLGGSLRVSAPGPVDAAAERLAARRAVENALHGGCGSVLLPPPYPPDRQSRDTTPPPGPRPATPYQSEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDA0</accession>
    <name>F4FDA0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_25160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734782.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25160"/>
    <dbReference type="EnsemblBacteria" id="AEB46130">
        <property type="protein sequence ID" value="AEB46130"/>
        <property type="gene ID" value="VAB18032_25160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25160"/>
    <dbReference type="eggNOG" id="COG1620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021628_0_0_11"/>
    <dbReference type="OMA" id="LFVYKMP"/>
    <dbReference type="OrthoDB" id="732251at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="575" mass="59143" checksum="EA727B95DD14C300" modified="2011-06-28" version="1">MYRPTLDPLADSLALSALVAGLPIVTLFLLLGVLRVRAWLAALGALAVALLVSVVAYSMPTGQALLTASQGATFALFPLVWTFGTAIWIYRMTVTSGHFDVLRRSFARVSDDQQVQALVIAFCFGSLLEGLAGQGTPVAITTVMLLALGFRPMKAATVALVANTVPAAFGPLGLPITTLARVTDLPTGDLGAMAGRQVPVIALFIPLLLVGMVGGRRGLRRTWHIALACGVSFALAQFLTSNYFAMALADIVAGLVSAVVVTVTARVWPPRRQDDPVIDAAAPAGPGTTVTPGGPIGSGAPGGSGAPGRPTEQAVAVVGRTDVASPTPDTSVEVWRAYAPYLVIVAIFGLSQVPAIADALNAVTVTFNWPGLHLLTTSGAPSTLPVFRFNWLSSTGTLLVLAGLVTMAILRVTVRTAVVAYGQTLASLRWAILTVCGLLALAFVMNGSGQTATLGTWMAGAGGLFALLSPVLGWLGVALTGSDTSSNSLFGALQVTAAQRAGLDPVLLAAANASGGVVGKMISLQNLTIAASAVGLNGREGDLFRRMFGWSVVLICAMAVLVGLQATPVLSWMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDB6</accession>
    <name>F4FDB6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rplJ</name>
        <name evidence="9" type="ordered locus">VAB18032_01215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735964.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01215"/>
    <dbReference type="EnsemblBacteria" id="AEB47327">
        <property type="protein sequence ID" value="AEB47327"/>
        <property type="gene ID" value="VAB18032_01215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01215"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_1_0_11"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="18837" checksum="AB821D651CB57C33" modified="2011-06-28" version="1">MADKPIRADKATAVAELTESFRSAGATVLTEYRGLTVSQLTQLRRSLGKETSYTVAKNTLAKRAAADAGISGLDELFTGPTALTFVSGDVVEAAKGLRDFAKANPKLVIKGGVFEGKAISAAEVTKLADLESREVLLAKLAGAMKGNLSKAAALFQAPLSKTARLAAALQDKREKEGAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDL0</accession>
    <name>F4FDL0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731046.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06245"/>
    <dbReference type="EnsemblBacteria" id="AEB42373">
        <property type="protein sequence ID" value="AEB42373"/>
        <property type="gene ID" value="VAB18032_06245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06245"/>
    <dbReference type="eggNOG" id="ENOG5033BVD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2025642_0_0_11"/>
    <dbReference type="OMA" id="GWLRVEY"/>
    <dbReference type="OrthoDB" id="1901070at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="13871" checksum="EC16EBDD4825AAB3" modified="2011-06-28" version="1">MTRDGYVARWRGREYQASPDGGDVRLYQAEPGDSFVEVRPGRYVRVVPATEVEELAYVRTTCTWKGQPFIVLGEHDGWLRVEYTGGRWPVAQAMRLEAFDFGVYQGWAPVGEVTDLREQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDV8</accession>
    <name>F4FDV8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_12625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732307.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12625"/>
    <dbReference type="EnsemblBacteria" id="AEB43639">
        <property type="protein sequence ID" value="AEB43639"/>
        <property type="gene ID" value="VAB18032_12625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12625"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_4_11"/>
    <dbReference type="OMA" id="RWTADQM"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="134"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="23808" checksum="69553BC176325EDC" modified="2011-06-28" version="1">MHIVIMGCGRVGSILAHNLESRGHSVAVIDQDADAFRRLGPEFAGTTVTGAGFDGDVLRQAGIERADAFAAVSSGDNSNIISARLARETFGVSRVAARIYDQRRAQVYERLGIPTVATVRWTADRMLRHLLPEGNVEIFRDPTSTVSIIEVPVHREWIGHRVQRLEQATGARVAYLLRFGIGTLPTASSVVQEGDQIFMLVTDDMVATVTEIAAAPDGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDW7</accession>
    <name>F4FDW7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732316.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12670"/>
    <dbReference type="EnsemblBacteria" id="AEB43648">
        <property type="protein sequence ID" value="AEB43648"/>
        <property type="gene ID" value="VAB18032_12670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12670"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050005_0_0_11"/>
    <dbReference type="OMA" id="AWSECAD"/>
    <dbReference type="OrthoDB" id="2021377at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="430" mass="46461" checksum="F3765D4180261224" modified="2011-06-28" version="1">MTLIDLGELTEPTDPQPPRSRRRPSGRGRQWPLALVALAALVGLTSAAPPPVRVHATVPGGLAADLFLTAQRIFTVTPVRGVTDGSRELTAYARPRRATVTPQRLVPLWRMPVAPGIRFFRVEDTAAGVLLSLVPSQDLGRSSETMLLDAATGQQRWRSAGFGTRDASGRVLLQTWAVQQSTTLRSVEVATGRELWSRTLPPSWVEHHQRDGVIDAIVVSTTAGDVEVLDARTGQLRDRLPAADSTGYQQSSVVDDLLLVVRNSRTITAYDLAGLVPRWQTTVPLADHVTSCGALLCARANRGGTHVIDPVAGDVRWSTSEDGDLLRVTPTRALAQLGESGLVTLDAATGRVLTGYGSWETVASYEQELRLLGIHLLPEVGAVLARLDPAEAQPRRLDVLPGVVGDCQSRYDLIACRRQSGDFGVWQLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE61</accession>
    <name>F4FE61_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="5" type="ordered locus">VAB18032_19140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">2 residues (Tyr-69 and Arg-72) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733585.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19140"/>
    <dbReference type="EnsemblBacteria" id="AEB44930">
        <property type="protein sequence ID" value="AEB44930"/>
        <property type="gene ID" value="VAB18032_19140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19140"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_11"/>
    <dbReference type="OMA" id="SMQVYPA"/>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="26739" checksum="9E2FBB1AAD122E59" modified="2011-06-28" version="1">MTESGPTQAAKLLGQARRTVVFTGAGMSAESGVPTFRDALTGLWQRYDAQQLATPEAFDADPDLVWGWYEWRRAVVARARPHPGHLAVAAIEARAPHSVLITQNVDDLHERAGSTAPLHLHGSLFAPRCSACAHPASTGDPAEPAEGRRLPPPRCDRCSAPIRPGVVWFGEALPQPALEAAAEAAASCDVLLTVGTSGLVYPAAEIPHVAARCGATVIQVNPEPTPLDQVSDINLRGPAARVLPTLVDAAWGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEB3</accession>
    <name>F4FEB3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional 3'-5' exonuclease/DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25405"/>
    <dbReference type="EnsemblBacteria" id="AEB46179">
        <property type="protein sequence ID" value="AEB46179"/>
        <property type="gene ID" value="VAB18032_25405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25405"/>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035229_0_0_11"/>
    <dbReference type="OMA" id="EVIVHCP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307846" evidence="2">
        <location>
            <begin position="24"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="3">
        <location>
            <begin position="306"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="548" mass="57122" checksum="9BB6791DC42CE478" modified="2011-06-28" version="1">MRACCARCAPTGSAPARPNPSPTSPPPSPHGRPPTGPAGSGPAARPSTPTLLRAGVRVERCHDVELTESLLLGHAGRWGEPRSLAAAWARLTGAPVPPDPPPRAPAPPGAGQAALFDAVPGPPGPGITALTRVYADQLDRIAATGHPGRFRLLVAAESAGALIAAEMGAAGLPWRADVHDAILAELLGEPSPVGGPPRRLADLAAQIAEAFGVRQVHADSPAELLRAFARAGIDLPNTRSWVLRGVDHPAVPLVLEYKELYRIWTAHGRAWRDAWVRDGRFQPEYVPGGVVSGRWATRGGGALQIPKVIRRAAMADPGWRFVVADAGQLEPRVLAAVSGDARLAAAGATGDLYQALARDAFGGDRGRAKLALLGAMYGQTGGEAVPALAGVRGNYPTAFGYVEAAARTGEAGGLVRSWLGRTCPPGSAGFATDEGVADPDAAGDPQSPRARAARSRGRFTRNFVIQATAAEWASTLLAVLRGELAGTEAELVFFQHDEVIVHCPAEQAERVAEAVQRAGRRATVLLFGDTPVRFPLDLSIVECYGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEI1</accession>
    <name>F4FEI1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase/Xis, DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736058.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01695"/>
    <dbReference type="EnsemblBacteria" id="AEB47423">
        <property type="protein sequence ID" value="AEB47423"/>
        <property type="gene ID" value="VAB18032_01695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01695"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_9_1_11"/>
    <dbReference type="OMA" id="LYQWKWR"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="7467" checksum="E3618077D2462A93" modified="2011-06-28" version="1">MTPPATPEPLWEIEDVSAYLRVPVQTLYQWRKRKYGPPAARVGRHLRYDPDVVRAWFAEQSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFC4</accession>
    <name>F4FFC4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="8">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hemH</name>
        <name evidence="8" type="synonym">cpfC</name>
        <name evidence="10" type="ordered locus">VAB18032_25640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734878.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25640"/>
    <dbReference type="EnsemblBacteria" id="AEB46226">
        <property type="protein sequence ID" value="AEB46226"/>
        <property type="gene ID" value="VAB18032_25640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25640"/>
    <dbReference type="eggNOG" id="COG0276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_2_0_11"/>
    <dbReference type="OMA" id="WLEPDIC"/>
    <dbReference type="OrthoDB" id="780534at2"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="343" mass="37831" checksum="E0A809EF2A0017DA" modified="2011-06-28" version="1">MAYDAVVLVSFGGPEGPDDVLPFLQNVTRGRGIPPQRLAEVAEHYRHFGGVSPINQQCRDLLAAIRADFAAHGLDLPVYWGNRNWHPMLADTFAQMRDDGVRRALAFVTSAFGGYSSCRQYQEDITAARAAVGPDAPVIEKIRQFWDHPGFVEPHVDAVRAALSQLDLTRRDHTRLVFTAHSVPVSMADSAGPHGGRYTAQLAETARLVHTAAASDLPYDLVWQSRSGPPHVPWLEPDINDHLTALAAKGVTAVVVSPIGFVSDHLEVIWDLDTEARDTATRLGLEYVRAQTPGTDPRFVTMVRELVQERIDPAGVDRRRRLGELPMWDSCPSVCCVPPRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFH6</accession>
    <name>F4FFH6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734929.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25900"/>
    <dbReference type="EnsemblBacteria" id="AEB46278">
        <property type="protein sequence ID" value="AEB46278"/>
        <property type="gene ID" value="VAB18032_25900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25900"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006954_1_0_11"/>
    <dbReference type="OMA" id="SIMAYAG"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="990" mass="102345" checksum="4001D5073A547AE2" modified="2011-06-28" version="1">MLPVLAAPTAAVAAPSSESLWRKVDGKPAPTKSGKKAAIKAKKQKTFTLDRAGIESLLDKAPAENRLAARQQRQLVSLPAPDGTFQRFELVESPVMEADLAAAHPEITTYAGKGVDDPTATVRADLTPLGFHASVRSSDGTWYIDPYYHRDQSLYASYFAKDLEDTHGEFHEHEDVETAAHALKEELGAQAEPTIGPLVSLRTYRLAMVTDPSYANYFGAENVTAAKVTLINRVNQIYEDETAIRLVLVNATDETNLNTPALATEPNGPCGAAPCYTPAQLAGCSSGLLNRNRIVLGQIVGASNYDVGHIALGLAGGGIAGLGVVGGDGKARGCTGLPNPVGDYFAVDYVAHEIGHQFAGNHTFNGNQHNCSGGNRSAANSYEPGSGSSIMAYAGICRQDNLQPHTDPYWSHRTFTEITTFVTATRPAINEVQTVSLLDFDADGDSFTISYGGANSAPIVRGVNYTTAGIKAAIEAIPGWPAGATVNVAAFGGSGTLNDTGFQVTFTGALAQTNVEQLALTNVFGASGFVGETSKGGAIDNGGHLVQETANHAPVVTVPDSVTIPVRTPFALTGSATDADGDVLTYLWEQNDRGGSAGTALMSNTKTNGPLFRVFGEAANVTPEDAQQYHSPGQNVVTTNSTRVFPDMKQILAGNTNAKTGACPVAPAPPTSGSASNVPAEIVDCYSEFLPTQDWVGFNNDRTMNFKLTARDGRLGGGGVGSANVAVALAPQAGPFLVTSQGTDAGLDGGSTQTVTWDVAGTDQAPVNVSEVKITLSADGGETFPYVLAERTANNGSADVRLPNVSTDKARIKIEAVGNVFFAVNEADFTILLNGGDAQQQITTTVKPGPLALSVAGSTVALPAVNLGDITTGALNQATVEDLRGTSAGWSLTGQVSDFTSTNGASIAAGNLGWVPSAEAQTERFIGTQGVVTPGAVAEPGAGLGEARALCTSAAGVSGGVFTCDAELNLGVPSSARAGDYIATLTLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFL0</accession>
    <name>F4FFL0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix type 11 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736121.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02015"/>
    <dbReference type="EnsemblBacteria" id="AEB47487">
        <property type="protein sequence ID" value="AEB47487"/>
        <property type="gene ID" value="VAB18032_02015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02015"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_5_0_11"/>
    <dbReference type="OMA" id="VWYLCAR"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="36073" checksum="A4FC42B08CC7D455" modified="2011-06-28" version="1">MRAARLISLLLLLQAREAMTAAELARELEVSERTVYRDIVALSAAGVPVYADRGRAGGYRLLGGYRTRLTGMTRDEAEALFLAGLPGPAGDMGLADAVAAAELKVLAALPPSLRDAPTRTGQRFHLDVPGWYAQHAPPPWLADLAGAVWRDRVVTLHYRRGDREVTRRVHPYGLVLKNGIWYLVGRVDADLRTYRVDRIVDVEPDEEAFEREPDFDLPAYWHAQAEAFLRGMLRAEVRIRLSPAGLRQLKHRSDIPFGYAEAVAAADEPDEQGWVTTRLPVESVDVAYTQLLGLGPEVEVLDPPDLRARLAEAAARAAALYTAPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFQ4</accession>
    <name>F4FFQ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02235"/>
    <dbReference type="EnsemblBacteria" id="AEB47531">
        <property type="protein sequence ID" value="AEB47531"/>
        <property type="gene ID" value="VAB18032_02235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02235"/>
    <dbReference type="eggNOG" id="ENOG503224S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1576715_0_0_11"/>
    <dbReference type="OMA" id="QCRDCAG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307701" evidence="1">
        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="169" mass="17493" checksum="47667A6BFF42C484" modified="2011-06-28" version="1">MALSWSRLAHLCASALLAVAVTGCAPFGDQRDPAGQPAAAGNAAGSSGKYRVSLLQNEGTDGPLRTLNVEPDGRWECVDCAGDGVTSTGALSQEHSERLQLLLADPALVMETDEARGYKVTCIGALTSSLLTTAGLITSQDCPGEERPPVAEEILLLLTQNTPAQLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG05</accession>
    <name>F4FG05_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731258.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07305"/>
    <dbReference type="EnsemblBacteria" id="AEB42585">
        <property type="protein sequence ID" value="AEB42585"/>
        <property type="gene ID" value="VAB18032_07305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07305"/>
    <dbReference type="eggNOG" id="COG5606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029927_5_0_11"/>
    <dbReference type="OMA" id="QPDVQAW"/>
    <dbReference type="OrthoDB" id="602102at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="451" mass="49071" checksum="F89DF6C4309EA52B" modified="2011-06-28" version="1">MATSDEIRNARRALGRRLAQLRKAAAYTQHGFAQLVQYGRSSVANTETGHQYPDRGFWARCDAVLQTGGALAAEYDRIAGMGRRRHRVTAMQEPGRMLRQATPIRTGTSTTESGNCDVLWEHENSIDARRLALKSGTDDDARLAYLEDEIRQAITDNERLTPTILTARLRPLRAYVDQLMWGRQHPPQRARLYTAAAHLSGLLGALALDLRAYRMAHAYAAEAFDLADAAQQPDVQAWARATQSLVAFYSGDYHDALAYAQDGLRRAGTSPHRIRLAVNGQARALAHLGDRYGVDRTVDGAFTMLSDYPVDSTVSASLTLGPYCQARTAANAATAYLALGRTSGVTDHLTTAITAFDAAGLAGPRALSRLDLATAHLHADNPDPERAATLAVEALTLTAEQRFESVHQRARQFLTAAQPFAHHPQLRHVADLLADRTQVGATAPSALPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG94</accession>
    <name>F4FG94_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733687.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19650"/>
    <dbReference type="EnsemblBacteria" id="AEB45032">
        <property type="protein sequence ID" value="AEB45032"/>
        <property type="gene ID" value="VAB18032_19650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19650"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_11"/>
    <dbReference type="OMA" id="NILHHWC"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="33888" checksum="6758B1F40C03C811" modified="2011-06-28" version="1">MPHWTYDDIPDQRGRTAIVTGANSGLGVETARALAGKGARVVLACRDRGRGEAAAEVIRARHPRSEVHCRPLDLADLDSVTAFATAYRAEHDRLDLLVNNAGVLYPPLRRTRQGFELQFGTNYLGHFALTGRLLPLLLATEQARIVNVASNAHRTGRIDLDDLNWQRRRYARFAAYGQSKLAMLLFTLELHRRLTGAGTSLRVTAAHPGWTYTGPSQGRDRLVTIVNGIGRYLAMPLSEGALPILRAATDPDAEGGSYWGPAHRAENVGPPVPATRSARAVDVEVAQQLWAQSERLTGVPIDLPPVDATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGB2</accession>
    <name>F4FGB2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoadipate enol-lactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733705.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19740"/>
    <dbReference type="ESTHER" id="verma-f4fgb2">
        <property type="family name" value="Carboxymethylbutenolide_lactonase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45050">
        <property type="protein sequence ID" value="AEB45050"/>
        <property type="gene ID" value="VAB18032_19740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19740"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_3_11"/>
    <dbReference type="OMA" id="MWRWQRE"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042952">
        <property type="term" value="P:beta-ketoadipate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026968">
        <property type="entry name" value="PcaD/CatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02427">
        <property type="entry name" value="protocat_pcaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="26727" checksum="88CFD094E094B923" modified="2011-06-28" version="1">MTLHATVDGPPDAPVLLLGSSLGTTGAMWQPQVAALADRFRVVRYDHLGHGRSPVPPGPYTIDLLGREVLGLLDHLGVGSAHYAGLSLGGMVGMWLAAHAPERIDRLALLCTSACLGPAQVWRARAAGVRAGQLGTIADTVVSRWFTPGFAAARPDTVAGYRDMLTATPPAGYAACCEAIAAMDLRADLAAVRAPTLVIGAADDPATPPEHAADIAERIPAARLAVVDDAAHLANVEQPAAVARLLRAHFEPEGGTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGC5</accession>
    <name>F4FGC5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional deaminase-reductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733718.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19805"/>
    <dbReference type="EnsemblBacteria" id="AEB45063">
        <property type="protein sequence ID" value="AEB45063"/>
        <property type="gene ID" value="VAB18032_19805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19805"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_3_11"/>
    <dbReference type="OMA" id="FEGPDHD"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="197" mass="22102" checksum="F01E750821192718" modified="2011-06-28" version="1">MPGRFVYWMNVSVDLRIEYAPGEAGGGKWMRITEPLHRVFNERARAMSLAVEGRTIYETMESFWPAARHDDSLPDFLREYGEIWTSMPKVLVSRTRTHADHNTRIIGGDDAIEQLAKLRAETDGVIGVGGATVATQLLRARLLDEVLLFTHPVVLGSGRPLFDAHDEPLELDLLEQASFDEGVTMHRYAVRGTRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGM2</accession>
    <name>F4FGM2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_26295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735008.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26295"/>
    <dbReference type="EnsemblBacteria" id="AEB46357">
        <property type="protein sequence ID" value="AEB46357"/>
        <property type="gene ID" value="VAB18032_26295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26295"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_0_3_11"/>
    <dbReference type="OMA" id="HVSGDYD"/>
    <dbReference type="OrthoDB" id="1534467at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="159" mass="16889" checksum="43EEFA6B885C2F5E" modified="2011-06-28" version="1">MPPASNVLRPFTGLDDTDRAILTELSADGRLPNNALAERVGVAPSTCLARTRALRESGAIRGFYADVDPAALGLPLQALVSVRLTEHARAAVDAFRARSVRLPGVVSVFHVAGAEDYVLHVRAASAEALRDFVLDHLAVDPAVQHTQTSLIFEQARGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGP2</accession>
    <name>F4FGP2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VbhA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735028.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26395"/>
    <dbReference type="EnsemblBacteria" id="AEB46377">
        <property type="protein sequence ID" value="AEB46377"/>
        <property type="gene ID" value="VAB18032_26395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26395"/>
    <dbReference type="HOGENOM" id="CLU_2959583_0_0_11"/>
    <dbReference type="OrthoDB" id="1702165at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041535">
        <property type="entry name" value="VbhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043038">
        <property type="entry name" value="VbhA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18495">
        <property type="entry name" value="VbhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VbhA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="59" mass="6519" checksum="1DE57FF26BA0D7B9" modified="2011-06-28" version="1">MSDVETAVANAVANAALAGVEFDEEWKRTLRDVATGLIDANELIAQEIVRFRSDRDAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGU6</accession>
    <name>F4FGU6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, card family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007073334.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02610"/>
    <dbReference type="EnsemblBacteria" id="AEB47606">
        <property type="protein sequence ID" value="AEB47606"/>
        <property type="gene ID" value="VAB18032_02610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02610"/>
    <dbReference type="eggNOG" id="COG1329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048259_1_2_11"/>
    <dbReference type="OMA" id="DMKVMIP"/>
    <dbReference type="OrthoDB" id="1942592at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="161" mass="17850" checksum="982AB6BA78180D9A" modified="2011-06-28" version="1">MVFSVGETVVYPHHGAALIEAIETRVIKGEPKQYLVLRVAQGDLTVRVPAENAEIVGVREVVGEEGLGKVFDVLRAPHTEEPTNWSRRYKANLEKLASGNPLKVAEVVRDLWRRERERGLSAGEKRMLAKARDILVGEVALAEKSTKDEAETLLDKVLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH14</accession>
    <name>F4FH14_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chromosome partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731301.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42628">
        <property type="protein sequence ID" value="AEB42628"/>
        <property type="gene ID" value="VAB18032_07540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07540"/>
    <dbReference type="eggNOG" id="ENOG5033UNE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107905_0_0_11"/>
    <dbReference type="OMA" id="HLHEVIG"/>
    <dbReference type="OrthoDB" id="1872752at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="164" mass="16901" checksum="234F9124EF70378C" modified="2011-06-28" version="1">MVIEAGLIAGYVIAWAVRKARRAAGRLDAEVDTAIDAGLDKLHDAVAAKLGAHPALDDLAEEAATEEGQVSELTRQQVELALTAAARKDDNFGQSVTELLAKLQAAEQASGVSVIGPGARVFTGNAHAHASGHGIAVGQVAGDVNTGATDRPQRDPSEPGRSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH17</accession>
    <name>F4FH17_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731304.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42631">
        <property type="protein sequence ID" value="AEB42631"/>
        <property type="gene ID" value="VAB18032_07555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07555"/>
    <dbReference type="eggNOG" id="ENOG5030QC7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712499_0_0_11"/>
    <dbReference type="OrthoDB" id="2118029at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="16902" checksum="42128ADB4C34FC5F" modified="2011-06-28" version="1">MHWFGLHPDPTSDDTDSRYRISRDRGDISPPLATWTPAAVTCDVVGGGAYRAMVAPGYTTLGRTGVLCRFPLFAVQRMAAHLDSLHPGGMPGEHPRLRFDGDEVVIEWEHDDGLGGRWVEHDRVVPDANGCYAIGAYQWPWVLVPAETTAPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH61</accession>
    <name>F4FH61_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13635"/>
    <dbReference type="EnsemblBacteria" id="AEB43839">
        <property type="protein sequence ID" value="AEB43839"/>
        <property type="gene ID" value="VAB18032_13635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13635"/>
    <dbReference type="eggNOG" id="ENOG50335PD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626368_0_0_11"/>
    <dbReference type="OMA" id="CSFGDGI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="16692" checksum="9E8E706C20EFAEB6" modified="2011-06-28" version="1">MLLATALALTGCGGSEPAARGAGPDAGSDADLDLPVDGADTVRPACPFTAEQVTGIVGQQLDDKGNCSFGDGIALLTVTTASRVAGEMTYDYQRQQADQTYQSVTDLGVGDKGYLAVKDIEAEAVVINGAGSFTVTLSSFQRLGAQPDGYAQAMRKLADALPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHC1</accession>
    <name>F4FHC1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PilT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_13935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13935"/>
    <dbReference type="EnsemblBacteria" id="AEB43899">
        <property type="protein sequence ID" value="AEB43899"/>
        <property type="gene ID" value="VAB18032_13935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13935"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137728_0_0_11"/>
    <dbReference type="OMA" id="GEMHRRH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="156" mass="17185" checksum="4203B39884ED8CD1" modified="2011-06-28" version="1">MATERIRGVANRAPDTIATLVDTNVLLDIFTDDPKWADWSAEALAAARDAGVLVINPIVYAEVSVRFARVEDLDDALPASDFLREELPYSAGFLAGKAYARYRRQGGAKRSPIADFYIGAHAAVCRYRLLTRDSSRYRTYFPTLTLIAPEGGPSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHW1</accession>
    <name>F4FHW1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02850"/>
    <dbReference type="EnsemblBacteria" id="AEB47654">
        <property type="protein sequence ID" value="AEB47654"/>
        <property type="gene ID" value="VAB18032_02850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02850"/>
    <dbReference type="eggNOG" id="ENOG5031H6Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165424_0_0_11"/>
    <dbReference type="OMA" id="DPAESAW"/>
    <dbReference type="OrthoDB" id="1735246at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="24713" checksum="8E44A05F24BEB02E" modified="2011-06-28" version="1">MTISQAGTTPVRPGRQRTAAAPTPEESLPTAWADYLAAARQLDGVRRDAATAASEQARTVQAAREELVTVRTRLAAQEARLCELGVPPISLAPTPPELSEATRSMSGGPAAVLASLREARRWAYGVDDILAARGLSRVAHLSPRPRNLLVYGPLGLLVPLLLIAIYLAAGTGPVTILALVVGLPGPAVAFGAGWLAVGRLFPSQPGERVDRTPRFGALACLIPAVVATAGIVLAMLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI36</accession>
    <name>F4FI36_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
            <plasmid evidence="1 2">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713122.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30184"/>
    <dbReference type="EnsemblBacteria" id="AEB48000">
        <property type="protein sequence ID" value="AEB48000"/>
        <property type="gene ID" value="VAB18032_30184"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30184"/>
    <dbReference type="eggNOG" id="ENOG5031VB1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2605098_0_0_11"/>
    <dbReference type="OrthoDB" id="1990240at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB48000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="8448" checksum="9DD0FFE80D282CAB" modified="2011-06-28" version="1">MAGRLVVRVQLDWTGPGHYDAGRALPCRCCDTPTKMRDGQGAACHKSCAEDEIARELLGTGRARIADERVPTPARLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI51</accession>
    <name>F4FI51_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30259"/>
    <dbReference type="EnsemblBacteria" id="AEB48015">
        <property type="protein sequence ID" value="AEB48015"/>
        <property type="gene ID" value="VAB18032_30259"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30259"/>
    <dbReference type="eggNOG" id="ENOG50313NZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936725_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="32473" checksum="FD74C517249B211F" modified="2011-06-28" version="1">MAGHRRIEHMKRPSRGASPVGAAVLVDDHGDTGRRIRPCGERRDLGPGQRRPARGHRQRRTPAFGQGDGLQRGPGDHGPARLVGLLGEPEQHLGRSEDRRRRAVQHRHHVRHAGWGVAGEADHRPVRIAVVTDTDHHPVAEPVDQLPAAASRGEPGRADLHIGEALPPKLVDQRRRPVRRVPDRPLAVDRHTLSGQPPGRRRAVGSVELGAVELGGHALSGQQALSPRVRHRRQARRAGDLSGQRPGAVPQRGGPVDRGRDALNDLPRRLVRCRHQGRPSSGSVGSSPRVRNDSNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1B5</accession>
    <name>F4F1B5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732618.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14195"/>
    <dbReference type="EnsemblBacteria" id="AEB43951">
        <property type="protein sequence ID" value="AEB43951"/>
        <property type="gene ID" value="VAB18032_14195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14195"/>
    <dbReference type="eggNOG" id="ENOG50332VQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219074_0_0_11"/>
    <dbReference type="OMA" id="GHHRYLT"/>
    <dbReference type="OrthoDB" id="1378381at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="240" mass="25515" checksum="8122E1DBC0319B35" modified="2011-06-28" version="1">MLDPAVPHLVVNSRALYFSWLPADPDAVAALVPAGLRPHPDRQVFMNQYVVDDPVQTSGFGSYSLAYLGVTLADVPAPDGVTPGGWWTHYVASSDQVRDYALARGAPALAGSTTIRSDHDKVVAETEIGGVPVIRAQARVGETGTTTHNGHHRYLTALDGQVVSSTYPVISEPVGGFEIESVEFLEPEHPVYALRPENPLTIAWGYYAPRSSFAYPGGLTVWGELELSSGATGVSAGPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1I1</accession>
    <name>F4F1I1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Thymidine kinase</fullName>
            <ecNumber evidence="2 9">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_20550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20550"/>
    <dbReference type="EnsemblBacteria" id="AEB45210">
        <property type="protein sequence ID" value="AEB45210"/>
        <property type="gene ID" value="VAB18032_20550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20550"/>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_2_0_11"/>
    <dbReference type="OMA" id="GTMDCGK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB45210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="232" mass="25512" checksum="373A36EB41223EAC" modified="2011-06-28" version="1">MSRPALDGSSDTPAGCVAARGVDGRPAHAAALRFYWGPMDCGKSTMALQMNYNHARQGRRGLVTTRIDRSLGPQVTTRIGLAHEAIEITDEVDLRALVRDAWADGVRVDYLICDEASFYSVQHVEQMAELVDSYDVDVYAFGLATDFRSCLFPAAQRLFELADTVARIQVEVLCWCGREGLLNARVAGGRVVREGEQVVIGDTVDTADVRYQVLCRRHHRSGDLGPRVTVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1M3</accession>
    <name>F4F1M3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase component I/chorismate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20760"/>
    <dbReference type="EnsemblBacteria" id="AEB45252">
        <property type="protein sequence ID" value="AEB45252"/>
        <property type="gene ID" value="VAB18032_20760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20760"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_1_0_11"/>
    <dbReference type="OMA" id="YQANLCR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="128"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="381" mass="40013" checksum="9D9628E05CC6DBCB" modified="2011-06-28" version="1">MVVAPPAAPTACRGRLVERARWQWRPTDGGDPATAIQDFLTAHDLHLHDLTRPAPRHDHDHEQLCGAALYVSAAAGALMVGGDPGPPSPADLPDVAVVVYGHTDTPPPPPPATSWSRGPWTESWSPPQHAAAVEAVRHAISRGQVYQVNLVGHAAAPYTGNPLPALARLGRLPGARYGGVLSGPDWAIGCASPETLIEVRDGTLTTRPIKGTRPATATGRADLLASRKERAEHIMIVDLERNDLARIAATGSVRVDDLFAVRRWCDLWQAESTIRAQAADGLGLADLLRAVCPGGSVTGAPKLAALHHIAALEPVGRGASMGGLGWVAPGHIDLGLTIRTAAVDHHTVHVWAGGGITWDSDPDAEVAEAAAKTRPVRAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1P4</accession>
    <name>F4F1P4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_26981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735120.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26981"/>
    <dbReference type="EnsemblBacteria" id="AEB46469">
        <property type="protein sequence ID" value="AEB46469"/>
        <property type="gene ID" value="VAB18032_26981"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26981"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_2_11"/>
    <dbReference type="OMA" id="WYINSGQ"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="403"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="467"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="535"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="602"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="662" mass="70447" checksum="AE11AD03DD315447" modified="2011-06-28" version="1">MDTQVADTLLGSLIDGRYRIRGRVARGGMATVYTATDERLERTVAVKIIHSSQGPTDRAGLAGFVERFTDEAKTIARLTHPNVVAVYDQGTHGGRPYLVMEYVRGRTLREVLTERRRLNPDEALAITEQILAALATAHRAGLVHRDVKPENVLVAEAPSGGPANLVDSVVKVTDFGLARAVEASTDHDSGNQLMATVAYVAPELVTTGRADARTDVYSSGIVLFEMLTGRVPYDGDRPIDIAWQHVDRDVPAPSTLVPGLPKALDDLVARATRRDPAGRPADAGTLLAEVQVARDGLGNANAQTAMLSAVSDGPAVAQPTMVVAAVRPAERPTWARLPEGGTPTRGRRRAVPDEDVHRFSPLAGWRARLFGDSSSRLAVAAVVVVLGLVAALGGWWFGVGRYTTTPQLVSMTKAQAEAQAAQGGFTLQYADPRHDEQIPRDGVVAQQPASAARILKGGTITLTLSLGPARFPMPDVVGKEFDLAEADLVNAQLKVVKGTARYDDGLPEGVVVATKPEAGKEVEPGDEITVILSKGRAPITVPNLVGKSLNDARTQIAQLGLVLVEPTYKQSDKPRDEVLGQSPADGSGVEKGAQIRLEVSEGPPLVTVPRVIDLPCQQAKQVLESQGFPVAVQFNPEAVARFQNPNENAQVAPGTQITIGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Q6</accession>
    <name>F4F1Q6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ordered locus">VAB18032_27041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27041"/>
    <dbReference type="EnsemblBacteria" id="AEB46481">
        <property type="protein sequence ID" value="AEB46481"/>
        <property type="gene ID" value="VAB18032_27041"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27041"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_11"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="159"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="268" mass="28078" checksum="F038117984574AF1" modified="2011-06-28" version="1">MRTVAVIGAGKIGELMLSGLLRSGWPVDRLLATARRPARAEELTARYGVRVVDNLTAVDEADVLAVSVKPQDAAVLLDEIGPKVPGGKLVISLCAGLPSSFFSRRLPEGTPVVRVMTNTPALVDEAMTAISAGAHATGEHLALAEEMFKPLGSTIRVPESQQDAVTALSGSGPAYFYLLVEAMTDAGILLGLPRQVAHDLIVQTAIGSAVMLRDSGEHPVKLREAVTSPAGTTISAVRELENHGVRAALLAALEAARDRARELAAQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F293</accession>
    <name>F4F293_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase sdr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731453.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08320"/>
    <dbReference type="EnsemblBacteria" id="AEB42782">
        <property type="protein sequence ID" value="AEB42782"/>
        <property type="gene ID" value="VAB18032_08320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08320"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OMA" id="DGPLDHY"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="24846" checksum="317DB6A7C4E52D06" modified="2011-06-28" version="1">MTVRSGHRVALVTGGSRGIGAAVARRLAEDGIHVAFTYRAAEASAKAVVADIEAYGRRGLSISADSADPVAIVGAVERTVAEFGRLDILVNNAGVFAGGPIESVSFEDLDRAVAVNVRGVYLATQAAVRHMGAGGRIVNIGSSFSSRVAAPGVSAYAMTKSAVNGLTRALARELGPRGITVNLILPGSTDTDMNPADSAAADAQRAQIALGRYASPADVAATVSHLVGDGGRHISGASIAVDGGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2I0</accession>
    <name>F4F2I0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxybutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14700"/>
    <dbReference type="EnsemblBacteria" id="AEB44052">
        <property type="protein sequence ID" value="AEB44052"/>
        <property type="gene ID" value="VAB18032_14700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14700"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OMA" id="FPADKWQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003858">
        <property type="term" value="F:3-hydroxybutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011294">
        <property type="entry name" value="3-OHbutyrate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01963">
        <property type="entry name" value="PHB_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="25973" checksum="C2172B6EC3231E56" modified="2011-06-28" version="1">MNVDLTGRIAVVTGGGSGIGRACALRLAVAGAQVLVVDRNAEAAEQVAAEAGGRAVGVDLADAAAVDRLDAGVDIVVNNAGLQHVAPIQDFPVERFEYLQRVMVEAPFLLIRRALPHMYAQGWGRVVNISSVHGLRASPYKAAYVAAKHALEGLSKVVALEGAAHGVTANCINPAYVRTALVEDQIADQAATHGIPETEVIEKIMLARAAIKRLIEPDEVAELLAYLCSPPAAFLTGASIALDGGWTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2K2</accession>
    <name>F4F2K2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cdp-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_20835</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733921.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20835"/>
    <dbReference type="EnsemblBacteria" id="AEB45267">
        <property type="protein sequence ID" value="AEB45267"/>
        <property type="gene ID" value="VAB18032_20835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20835"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_6_1_11"/>
    <dbReference type="OMA" id="GTTLYWW"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB45267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="22610" checksum="A12D34B49CF6EAD4" modified="2011-06-28" version="1">MSRRPARTEPPQAADAGGEHRVLTVPNVISFVRLAGVPLFLYLFLVARADVAAVVVLAVGGTSDWVDGWIARRLRQVSRLGELLDPLADRLYILAVLIAFTARDVVPWQFTAALLAREALLLVSLAVLRRHGYGPPPVHYVGKTATFLLLAAFPLLLLAATVSATTAVAHPMGWALAWWGLVLYWVAGAFYVIQARQLVRAVRGRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2K6</accession>
    <name>F4F2K6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733925.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20855"/>
    <dbReference type="EnsemblBacteria" id="AEB45271">
        <property type="protein sequence ID" value="AEB45271"/>
        <property type="gene ID" value="VAB18032_20855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20855"/>
    <dbReference type="eggNOG" id="ENOG5032DYN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2771306_0_0_11"/>
    <dbReference type="OrthoDB" id="2016012at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="70" mass="7717" checksum="01D3A67DC7489FF4" modified="2011-06-28" version="1">MPGPRPGSNAYDKQRARLRNALDNSGRGVTDERADEAANRILQDERGQRGIARGERTYGPKGNREPGDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Q3</accession>
    <name>F4F2Q3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferredoxin-dependent glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_21090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733972.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21090"/>
    <dbReference type="EnsemblBacteria" id="AEB45318">
        <property type="protein sequence ID" value="AEB45318"/>
        <property type="gene ID" value="VAB18032_21090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21090"/>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026563_1_1_11"/>
    <dbReference type="OMA" id="MWRMARS"/>
    <dbReference type="OrthoDB" id="151647at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="3">
        <location>
            <begin position="143"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="524" mass="55882" checksum="39C7493A496962DC" modified="2011-06-28" version="1">MRWARHAVPAAVAALAAVATRDLLQREHALRRNFPLLGRARYLLEAIGPELRQYIVAGNNEERPFTRDQRRWVYASAKQQNNYFGFGTDNDIEFTPGYPVIKHRTFGRAVPASTPTVGHEVRLPCAKVLGAARGRARAFRPESVVNLSGMSFGSLSGPAVEALNRGAAIAGCLHNTGEGGLSPYHRHGGELIFQLGTAYFGCRDDRGRFDLARLKDVVAGAPVRALEIKLSQGAKPSLGGLLPAAKVSAEIAATRGIPVGRDCVSPSRHAEFSDCDSLLDWVELLAAETGLPVGIKSAVGDLDFWTELTDLMRDTGRGVDFVTVDGGEGGTGAAPLIFTDSVSLPFQQGFTRVYTTFAERDLHEQVVFVGSGKLGLPDNATVAFALGCDMVAVGREAMLAIGCIQAQKCHADSCPTGVATQNAWLTRGLDPASKAVRAAHYVKTLRRDLLKVAEACGVEHPGLIDTDAVEILGGRTTSTPLREVYGYRPDWGLPSAADRAAIAELMSQESPQGGSATPSPTAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F336</accession>
    <name>F4F336_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="3">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_03665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. Acts synergistically with the xylanases and binds specifically to xylan. From small arabinoxylo-oligosides (ranging from arabinoxylotriose to arabinoxylohexaose), it liberates arabinose and, after prolonged incubation, the purified enzyme exhibits some xylanolytic activity as well.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03665"/>
    <dbReference type="EnsemblBacteria" id="AEB47815">
        <property type="protein sequence ID" value="AEB47815"/>
        <property type="gene ID" value="VAB18032_03665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03665"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041805_2_0_11"/>
    <dbReference type="OMA" id="QYDDWGG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="PTHR40631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307369" description="Alpha-L-arabinofuranosidase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="5">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="503" mass="54595" checksum="35263C06709133F5" modified="2011-06-28" version="1">MLAPPSRRRGRLLRVVAAGVAAVVGGVTAVAVTSTPAAAATVDTNAWYVLVNRNSGKALDVYNLATNDGARITQWTRNNGNQQQWQFVDSGGGYYRLKSRLSGKVLDIYNWSTANGGSIVQWTDHNGANQQFRLADSDGGHVRLISRHSNKVVEVQGASTADGGNIVQYDDWNGANQQWQLVRVDGGNNPDPTPTTPPPTGTCNLPSSYRWSSTGALAQPRSGWVSLKDFTHAPYNGQHLVYATTHDTGTTWGSMNFGLFSNWNQMGSASQNQMPFAAVAPSLFYFAPRNIWVLAYQWGGPAFSYRTSTNPANVNSWSAHQTLFTGSISNSGTGPIDQALIGDDQNMYLFFAGDNGRIYRASMPIGNFPGSFGSNYTTIMTDTTNNLFEGVQVYKLQGQQRYLMLVEAIGSQGRYFRSFTATSLGGTWTPQAATESNPFAGKANSNATWTNDISHGELIRSNADQTMTVDPCNLQLLYQGRAPNSGGDYGLLPYRPGVLTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3A3</accession>
    <name>F4F3A3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_08545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731498.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08545"/>
    <dbReference type="EnsemblBacteria" id="AEB42827">
        <property type="protein sequence ID" value="AEB42827"/>
        <property type="gene ID" value="VAB18032_08545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08545"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_11"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="35053" checksum="24C20A508BD6E8D3" modified="2011-06-28" version="1">MKLLVTGGAGFIGSVVTRMLLDAGHQVVVLDDLRTGHREALAPDATFVEAGIHDAARVLTPEAGFDGVLHFAALIAAGESMVAPERYWHNNTVGSLALLDAVRAAGVPRLVFSSTAAVYGNPVELPIVETAIKAPTNTYGATKLAVDMALTSEAIGHGLAAVSLRYFNVAGAYLDGDTALGERHDPETHLIPIALEVAADRRDKLQLFGDDYPTIDGTCVRDYIHVADLARAHLLALDAAVPGQHRIYNLGNGNGFTNRQVVEVVREITGHPLPVEMAPRREGDPAELVASAALARAELGWEPQKPTLHDMISDAWFFYRTHRLAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3D5</accession>
    <name>F4F3D5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_08705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731530.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08705"/>
    <dbReference type="EnsemblBacteria" id="AEB42859">
        <property type="protein sequence ID" value="AEB42859"/>
        <property type="gene ID" value="VAB18032_08705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08705"/>
    <dbReference type="eggNOG" id="COG1294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049294_0_1_11"/>
    <dbReference type="OMA" id="MELAWYA"/>
    <dbReference type="OrthoDB" id="761975at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="335" mass="34691" checksum="C44F0297D16F595E" modified="2011-06-28" version="1">MELAWYALLGLFFAGYLVLGGYDYGVGLLLARRTDPARRRAALNAVGPFFLGNEVWLVAAVGILFGAFPVLEGELLAGSYPAVLGALVGVILVTVGVQLRSRPASGWARAGWDRVIVVGSLLAALGWGVVLAGLLQGVPRHLDGHVVGVTHLFTPFAAAAALALVALVAAHGATFLTLRLPAAEADRLRPLARRLVLTAAGAVGTAAVVGLSSDRVRVAAQRPAVGVLLAVGLVAALLVARTALGRRRDGVAFTATATALALPVLLVGATLWPYALVSTVDPAASLTVTEAAASAPTLRLLGWLAVPLLPALLGFQAMCLWIFRGRTEGRALVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F439</accession>
    <name>F4F439_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_28061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735335.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28061"/>
    <dbReference type="EnsemblBacteria" id="AEB46685">
        <property type="protein sequence ID" value="AEB46685"/>
        <property type="gene ID" value="VAB18032_28061"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28061"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002470_0_1_11"/>
    <dbReference type="OMA" id="TEFGRGW"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313578" evidence="2">
        <location>
            <begin position="44"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="506"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="694"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="4">
        <location>
            <begin position="826"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="951" mass="98884" checksum="AD7E1A3518448A5D" modified="2011-06-28" version="1">MDSTRHPARWLTSGAALLLAVTAGTVALGVGPTALGGPTPAQAHPIVATDFQQVTLAKGVAEVGEPMTLAVLPDRSVLHTARNGTLRRTDAAGNTTVIGTIPVYTHDEEGLQGVGVDPNFASNRHIFLYYAPPLSTPGGDAPATGTSFSAWQGVNRLSRFTLNADFTVNAASKVDVLDVAADRGMCCHVGGDIDFDAAGNLYLSTGDDTNPFDSGGYAPIDERTNRNPAYDAQRSAANTNDLRGKILRIKVNANGSYSIPAGNMFAPGTANTRPEIYAMGLRNPFRMSVDKATGIVYVGDYGPDAGSTSARGPSGQVEFNRITGPGFYGWPYCTGTNTTNETYAEWNFANNTAGAKYNCTGGATNNSFRNTGLTTLPAAKPAWIRYAGDAGSPPEFGGGSESPSGGPVYRYNAASTSTTKWPQSFDGQFFAGEFGRGWIKPIHVNADGSVGTIDASFPWNGKQVMDMAFGPDGALYVLDYGTGYYNGDANSALYRYDYVGGGNRAPTAVASANRTSGIAPLTVNFSSAGSSDPEGGTLTYSWAFGDGTTSTAANPSKTYTANGNYTATLTVRDPQGATGTASVRIGVGNTAPTVTITSPGNGQLFSFGDTVPFSITVTDPEDGTIDCTRVKMTYVLGHDSHGHQITSQNGCTGTISVPVDGEHDDAANIFGIFDAEYTDAGGLTTHTQHTLQPRKRQAEHYRTASGVDAFDKPTAEGGKTVGNINNGDWIAFEPYRLGNVTSFSARVSSAGAGGTLQVRTGSATGTVLGSATVPVTGAWDSFTTVTGAIGNPPTGTTTLYLTFAGSGTGHLYDLDSFAFTTGSGDRTGPITGLGGKCLDVRNAATADGTQIQIFTCNGSAAQTWTVTPNSTIRALGKCLDVNAAASADGTKIQLWTCNGGVAQVWSAQSNGTLRNPNSGKCLDVSNNSSADGQAVHLWTCHTNANQRWILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F459</accession>
    <name>F4F459_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736504.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03950"/>
    <dbReference type="EnsemblBacteria" id="AEB47872">
        <property type="protein sequence ID" value="AEB47872"/>
        <property type="gene ID" value="VAB18032_03950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03950"/>
    <dbReference type="eggNOG" id="ENOG50310G9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2107990_0_0_11"/>
    <dbReference type="OMA" id="AYASDDC"/>
    <dbReference type="OrthoDB" id="2071811at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307407" evidence="1">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="115" mass="12296" checksum="D8D837E9B808A65B" modified="2011-06-28" version="1">MRKTAKRIASVLAVAALTTTLAAAPAVAKEVAREPFKVPDQGLVLYTANSAYVVARHTAADDLCHPMQDAVTSISWTPVYAIAYASDDCTGYGLQLSGWQGWSPGVFLSYKLIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F477</accession>
    <name>F4F477_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04040"/>
    <dbReference type="EnsemblBacteria" id="AEB47890">
        <property type="protein sequence ID" value="AEB47890"/>
        <property type="gene ID" value="VAB18032_04040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04040"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_13_0_11"/>
    <dbReference type="OMA" id="ICHHGAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="127" mass="13543" checksum="468379303A6D7CFB" modified="2011-06-28" version="1">MASILAGPAEDLPLVPVFGSQIPTVTVSEITDDTYLLDVREDDEWAAGHAPEAHHLPMMELPARIAEVPTDRDVAVICRSGGRSAQVVAYLMRNGWDQVRNVAGGMGDWASAGRPVVADNGQPGRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4D9</accession>
    <name>F4F4D9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42897">
        <property type="protein sequence ID" value="AEB42897"/>
        <property type="gene ID" value="VAB18032_08895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08895"/>
    <dbReference type="eggNOG" id="ENOG5030S5R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144124_0_0_11"/>
    <dbReference type="OMA" id="MIPEEGH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="142" mass="15410" checksum="0F330A67E6E59327" modified="2011-06-28" version="1">MGGYRTIEADIRQMREFADRLRAEVESNYTPHLRYIASDMLTQVSNPADAFIELVQFMRAHWETQQAATNAVWGVGHTTGHLAEAAHQVALRYGDADAFSAARVADIERALARPGITTAPPAPSPSFADPTGPDQPGPVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4G8</accession>
    <name>F4F4G8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731597.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09040"/>
    <dbReference type="EnsemblBacteria" id="AEB42926">
        <property type="protein sequence ID" value="AEB42926"/>
        <property type="gene ID" value="VAB18032_09040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09040"/>
    <dbReference type="eggNOG" id="ENOG5033C4E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095244_1_0_11"/>
    <dbReference type="OMA" id="QHADREP"/>
    <dbReference type="OrthoDB" id="1684239at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025339">
        <property type="entry name" value="DUF4245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14030">
        <property type="entry name" value="DUF4245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="22498" checksum="8582E8F23EEAC452" modified="2011-06-28" version="1">MEPAQHADREPADQTPGDDRPTADRSGGPGIGQPLPGPSAGAAKPASTRSPRDMAISLLVLLVPIALLLAFYRGFLGGDQPTSVDPTPAFEQARAAAEFPVSEPSGLGEGWRTVRASYRAVEGGATLRVGYVTPEGRGLQLVQSNVPPEQLLPTELTERGQPQGQADLGGGTWQRYTARGNEQALVLLQPERTVIVIGDARDNELREMASAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4I3</accession>
    <name>F4F4I3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_09115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731612.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09115"/>
    <dbReference type="EnsemblBacteria" id="AEB42941">
        <property type="protein sequence ID" value="AEB42941"/>
        <property type="gene ID" value="VAB18032_09115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09115"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="IHVMRFN"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="357" mass="38791" checksum="0EA460CD41A4AE2E" modified="2011-06-28" version="1">MIDVRLTAVSKRFDKSSDAAAVDEVTVTIGAGEFFTLLGPSGCGKTTTLRMVAGFYFPTSGQIHFGDDDVTHWSPNKRDTGMVFQNYALFPHMTVAQNVAYGLRVRRVSRTERDRRVSEALAQVHLSGYGARRIDALSGGQQQRVALARALVIRPRTLLLDEPLSNLDAKLREETRTEIRRIQRESGNTAIYVTHDQAEAMAMSDRIAVMQSGKVQQVGSPQEIYYRPTNAFVARFIGRSNVLSLPVVGAGENRVEVRLSSGATIEVGAATGHGLTEGDTALVSARPEHITLAGGDEESALRGRVTHVEFTGMATNLTVDCDGTEVMAAVIDAPATINVGDLVGLRLVRERLWVVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4P1</accession>
    <name>F4F4P1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15355"/>
    <dbReference type="EnsemblBacteria" id="AEB44183">
        <property type="protein sequence ID" value="AEB44183"/>
        <property type="gene ID" value="VAB18032_15355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15355"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169722_0_0_11"/>
    <dbReference type="OMA" id="MATIEEC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12503" checksum="A4129D71C0894E2F" modified="2011-06-28" version="1">MVATVDECRQALQDLAARLESNAQTVRERVDLDRTLACRITDLETAFHGRISDGRLIDLADGDDPKAKIALSTTSDDLVALVRGELDVTRAVANRRVSIKANPFDLMKLRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5C5</accession>
    <name>F4F5C5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04455"/>
    <dbReference type="EnsemblBacteria" id="AEB47973">
        <property type="protein sequence ID" value="AEB47973"/>
        <property type="gene ID" value="VAB18032_04455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04455"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_5_1_11"/>
    <dbReference type="OMA" id="QPTCSHY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="95" mass="10260" checksum="EAF65603453C109E" modified="2011-06-28" version="1">MNTEPKTGRPATLGARMLALPIIAYRRWISPALPARCRFYPSCSAYALEAVTRHGALRGAGLTVRRLSRCHPFNPGGYDPVPVPGDRRAADVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5D4</accession>
    <name>F4F5D4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gyrB</name>
        <name evidence="12" type="ordered locus">VAB18032_04500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736613.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04500"/>
    <dbReference type="EnsemblBacteria" id="AEB47982">
        <property type="protein sequence ID" value="AEB47982"/>
        <property type="gene ID" value="VAB18032_04500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04500"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_11"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="425"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="648" mass="71982" checksum="02D557C266B43F67" modified="2011-06-28" version="1">MAAQENQQYGAESITVLEGLEAVRKRPGMYIGSTGERGLHHLVWEVVDNAVDEALAGHCDTIDVVLLADGGVRVTDNGRGFPVDLHPKLKKPGVEVALTVLHAGGKFDGKAYAVSGGLHGVGVSVVNALSTRMAVEIHKDGFVWRQQYDHSKPSTLEKGEPTDRTGSAVSFWPDPDVFETTDFDFQTIYRRLQEMAFLTRGLTIHLLDERVAEGEDGKVREVTFKYDGGIADFVRHLNASKSPMHKTVIEFGAEEEGMSLEIAMQWNESYGESVYTFANNINTHEGGTHEEGFRAALTSVVNRYGADKKLLKGDEKLSGEDIREGLAAIISVKLTNPQFEGQTKTKLGNTPVKSFVQRVCNDRLVDWLDRNPAEAKIIITKASQAARARIAAQQARKLARRKSLLESGSMPGKLADCQSTDPRESEVFIVEGDSAGGSAKQGRDPRTQAILPIRGKILNVEKARIDRVLKNNEVQALITALGTGIHDDFDMEKLRYHKVVLMADADVDGQHIQTLLLTLLFRFMRPLVELGHVYLAAPPLYKIKWNKKGDDAQYAYSDRERDGLIALRQQKKPNAKPDDIQRFKGLGEMNYPELWETTMNPATRTLRQVTLDDAATADELFSVLMGEDVEARRSFIQRNAKDVRFLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5G5</accession>
    <name>F4F5G5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09395"/>
    <dbReference type="EnsemblBacteria" id="AEB42997">
        <property type="protein sequence ID" value="AEB42997"/>
        <property type="gene ID" value="VAB18032_09395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09395"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="VEPDFFV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24532" checksum="0894293EF795D445" modified="2011-06-28" version="1">MIAVAESERGTQAAQGTQAERVRVGLAHGSSSVRLRMALAAGTTPDPQVVDVLVERCAVEPEFFVREMLTWALTRQPASVTVPRLIEELRSASGQARSQALHTLSKIGDRRAWPAITHELLTDADDEVARSAWRAAVVLVPEGAESGLVAVLATQLGRGERETQLSLSRALVGLGEVIMPVLRAATTHPDPRVRQHAIATEQLWRDPDTGFDFAVEEAKRIVALGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5H3</accession>
    <name>F4F5H3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731676.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09435"/>
    <dbReference type="EnsemblBacteria" id="AEB43005">
        <property type="protein sequence ID" value="AEB43005"/>
        <property type="gene ID" value="VAB18032_09435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09435"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076053_1_0_11"/>
    <dbReference type="OMA" id="ATFANWV"/>
    <dbReference type="OrthoDB" id="1389630at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017523">
        <property type="entry name" value="CHP03089"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03089">
        <property type="entry name" value="TIGR03089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="24346" checksum="2FBA3A649A9C78F7" modified="2011-06-28" version="1">MADNIARVFADAIATDPNRPLLTWYDDATGERTELSGATLANWVAKTANLLTDELALGPGGTAAVLLPPHWQTAAVLLGCWAAGLTVAEQPGDVDVLFAAADRVAEADAWSADERYALALHPFALPLREVPAGFADYVTEVRVHGDHFGAYPPGGPAHTALIERARARAAELGISPADRVLIDVDRHPDPLDWLLAPLTANATVVLCAHPDPTLLPTRQSTEHTTHTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F613</accession>
    <name>F4F613_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_22360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734225.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22360"/>
    <dbReference type="EnsemblBacteria" id="AEB45572">
        <property type="protein sequence ID" value="AEB45572"/>
        <property type="gene ID" value="VAB18032_22360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22360"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OMA" id="LMSVFTM"/>
    <dbReference type="OrthoDB" id="1884934at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="291" mass="31993" checksum="492514CA1DAD3598" modified="2011-06-28" version="1">MSRPRRPLTGWAFLAPYAIAVALLVAVPALLNLGYAFTDHTGLTRDPQFIGLDNIRRMLDDRFLLDSLEASLFHVALAVPVRFVAAVGLGLLLAAPRPGGRWFRTAVYLPTVIPDVALAVLFLWVLNPLYGPLNQLLGLFGHQGYNWLADPTTARIGVVLMLAFPIGEGFVVVLAARRLLNGRLYEAAALEGCGPFGQLRRLTLPLLAPVLVLLAVRDIILTLQVNFVPAYVLTDGRPANATLYLPVYIFDQVFEFSGFAYGSLVTILLMLITAVIIIVLLLAVRRWRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F625</accession>
    <name>F4F625_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28531"/>
    <dbReference type="EnsemblBacteria" id="AEB46777">
        <property type="protein sequence ID" value="AEB46777"/>
        <property type="gene ID" value="VAB18032_28531"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28531"/>
    <dbReference type="eggNOG" id="ENOG5032H3V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037752_0_0_11"/>
    <dbReference type="OMA" id="CCGCPAY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="539" mass="55804" checksum="17BE1DB32A3907A9" modified="2011-06-28" version="1">MPEPQPGTDRPVDGNRPDAHRDGEPAVTQEQPTPVVLGAPTGPDGTRVLPADAPDPTSAPRDADQPTREDSAVGSDATAAPPADADATAPTATAPGQPDDVPRSPRQAAGGSGDAHPTKIDPGDAQRTTIDPGEAQRTAIDPGDAQRTAIDPGDAQSAGTPPTAVGPQGTRVMSQPVPDEEPAPRWSGSAAVPPAAPRRPSWGESAEPTPPPVAAAHQPEHQTPVDPWAGVDTSGWELHSADFPALPPTLSYPAPPPTTPYSGPPAHQPPAQQPPAANFPPPAVPAPPMPPASPAYPQAGYPPPPVHQAPAPSPRPAARPPAPVGPPPPPARGRKVKKLPPAAPPPGWQPPPGNVRARKRRRWPWVLLLTLACCCGCPAYYGMPMATQYPADAALPRQVADLRLREDPRNAQTARKLEAQTRQAHLLSDNIFAGVYTTSVGKRVTVFGGTGFRLTPSSDADAEIERLTQEYSLGAAEVVDSGVRGRHGRCAVGSSDGIGVVVCTSVDHGSLTTAVFTGLSVDDSARLLDTLREEIITPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F630</accession>
    <name>F4F630_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase, sigma subunit, ECF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_28556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28556"/>
    <dbReference type="EnsemblBacteria" id="AEB46782">
        <property type="protein sequence ID" value="AEB46782"/>
        <property type="gene ID" value="VAB18032_28556"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28556"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_0_11"/>
    <dbReference type="OMA" id="HQIAHRA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="286" mass="31712" checksum="7392EE5DDB5CE129" modified="2011-06-28" version="1">MEAAGALEAHRPMLLGLAYRLLGSRHDAEDVLQEAYLRWMRVDRAGVAEPRRYLSRVVTHLAIDRLRARQAAREAYVGMWLPEPVPTAPSPFGPLERAELRDSLATALLHLLERLTPPERAVYVLHTAFEMPYAEIAELLDRSAEDCRQLHHRAAMRIGRDQRRFTIDRAEQQRLLDAFIAAVDDGDLAALTDLVAAEATAWSDGGGRVRSARNPVTGVDRVTRFLLGIRAKGWPLTVHRTELNGQPAAVVVTAAGHRYALTLATADGRITDIFLVANPDKLAWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6I2</accession>
    <name>F4F6I2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16000"/>
    <dbReference type="EnsemblBacteria" id="AEB44310">
        <property type="protein sequence ID" value="AEB44310"/>
        <property type="gene ID" value="VAB18032_16000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16000"/>
    <dbReference type="eggNOG" id="ENOG50320NR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1069376_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="27620" checksum="11968FE387BA8416" modified="2011-06-28" version="1">MRGYRITVQVRLHVWATASRSADAHHAARTAMQAHLPALAAAGIVLTGLTWLADSPDDSAVSQSSSAGQSTADDDLAAATAERAAAFDALVGLRRKIRARAIRALVDAEFDGPYQPSARRVDRFLTGLGLDALPRAHHITVVVELTLLVVARTVEQACDAASQVMRAVTSTGLGAAWEAYGGAESDYATGEHGRWRVPWRHEYETWLRGHATSADAGAAAHAAVRVALHHTLAGLAHELMTVTATVHTAGIDQFLDPESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6I3</accession>
    <name>F4F6I3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732973.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16005"/>
    <dbReference type="EnsemblBacteria" id="AEB44311">
        <property type="protein sequence ID" value="AEB44311"/>
        <property type="gene ID" value="VAB18032_16005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16005"/>
    <dbReference type="eggNOG" id="ENOG5031GJC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030181_0_0_11"/>
    <dbReference type="OMA" id="CARRCEF"/>
    <dbReference type="OrthoDB" id="2064731at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="339" mass="36204" checksum="EE2865A3904E362E" modified="2011-06-28" version="1">MSFTEKLTLRSPADVVTAVPYLLGFHPTDASIVVIVSRHGRVVFAARTDLPAPDAPAHQIRDLAGRLIPVLHQQQPITELLLVGYGTAEHVDPALHAVRDTFTAEGMTVQEILRVTGTRFVSLLCDNRACCPPEGTPFDPTASLVAVQATAAGLVAFPDRAAVAARFAPLTGAARDRMQQATDTAVARLEALLADDTAAVDEAGPQAVRAALRHPDRALTDDEAAWLTVLLVRLSVRDLAADLSPPTDQYVTFWTDITRRAHETLVPAPATLLAITAWRCGDGALAAMAAERALQVDPGYRLADLLLQALHAGLPPSMFEQTATPTDPDAGWSSCPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Q0</accession>
    <name>F4F6Q0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">orfS</name>
        <name evidence="3" type="ordered locus">VAB18032_16360</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733038.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16360"/>
    <dbReference type="EnsemblBacteria" id="AEB44378">
        <property type="protein sequence ID" value="AEB44378"/>
        <property type="gene ID" value="VAB18032_16360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16360"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_2_11"/>
    <dbReference type="OMA" id="QACAEDK"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEK75517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="197" mass="21170" checksum="C8D3CA298AFB11E0" modified="2011-06-28" version="1">MTTERADAARNRAMILRATEDLLTYREAMPISVDSIAARAGVGKGTVFRRFGSRSGLFRELLAERATRIGEQISHGPPPLGPGAPPGDRLLAFLDALADLAATNATLLAAHAMACAAGRHDDPTYRRWHEHLRQLVGQLRPDLDAGYVAHVLLGAFDAELVRRTIADGGGDRLRAAVRALARCLLPPGPERSCRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6R9</accession>
    <name>F4F6R9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_22470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734246.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22470"/>
    <dbReference type="EnsemblBacteria" id="AEB45594">
        <property type="protein sequence ID" value="AEB45594"/>
        <property type="gene ID" value="VAB18032_22470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22470"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_4_11"/>
    <dbReference type="OMA" id="RRDFINW"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="78"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB45594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="171" mass="16039" checksum="816E7C1045A42B54" modified="2011-06-28" version="1">MNHEQAGCCRSRRALLAGTGAAGVAALTGCATYGQPAAAPPPAAPGGNTAPAGGSAAPGGGSPAPGGSGAPDDEPGPPALATLADIPVGGGAIFASAGVVVTQPTEGTIKAFSATCTHQGCTVTSVDNGAITCACHNSVFDIADGSVRSGPARAPLPAANVTVDGDAIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F760</accession>
    <name>F4F760_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_29266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735572.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29266"/>
    <dbReference type="EnsemblBacteria" id="AEB46924">
        <property type="protein sequence ID" value="AEB46924"/>
        <property type="gene ID" value="VAB18032_29266"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29266"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="WTIPTFG"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="34973" checksum="CC941E8AA60BC2F1" modified="2011-06-28" version="1">MTTTTPPAAVGAQQSDGSTRASRVRKRLNSRTATVVAIVIAVVWTIPTFGLFISSFRPEAELKTTGWWTAFTDPQFTLKNYQDVLFGQTASSGQLANYFVNSLVITLPSVLFPLAFAALAAYALAWINFRGRDWLYIGIFALQIVPLQMALVPLLSFFSRGVSLGGVTLMPAWNLDGAQNFAQVWFAHTCFALPFAVFLLHNFISQLPKDLMEAARVDGATHPKIFRTIVLPLVAPALAAFAIFQFLWVWNDLLVALIFAGGSEVTAPLTVRLAELAGTRGNEWQRLTAGAFVSIVVPLIVFLSLQRYFVRGLLAGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7B0</accession>
    <name>F4F7B0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10250"/>
    <dbReference type="EnsemblBacteria" id="AEB43168">
        <property type="protein sequence ID" value="AEB43168"/>
        <property type="gene ID" value="VAB18032_10250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10250"/>
    <dbReference type="eggNOG" id="ENOG5032I8M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157192_0_0_11"/>
    <dbReference type="OMA" id="VCRNDAS"/>
    <dbReference type="OrthoDB" id="2006855at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="104" mass="11004" checksum="D84526363E111BC5" modified="2011-06-28" version="1">MPSSSTLRPTAPTGEPAGAAMREIPLPPYVTAEDAQFAVRAVVVHAPRRWSGGTVCRNDASPHPCRLHRWGTRVLALRGLHDADIAALIERGDPAAPLPPSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7D2</accession>
    <name>F4F7D2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="3" type="ordered locus">VAB18032_10360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731861.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10360"/>
    <dbReference type="EnsemblBacteria" id="AEB43190">
        <property type="protein sequence ID" value="AEB43190"/>
        <property type="gene ID" value="VAB18032_10360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10360"/>
    <dbReference type="eggNOG" id="COG2127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153743_1_0_11"/>
    <dbReference type="OMA" id="RDVQAMH"/>
    <dbReference type="OrthoDB" id="1829294at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="96" mass="10784" checksum="CA15DF7BAF2DF0C7" modified="2011-06-28" version="1">MAAPQVAPVETPATDEVSASDRPWVTIVWDDPVNLMSYVTWVFQKLFGYSREKAEQLMLDVHHKGKAVVSSGARERMEHDAAQLHAYGLWATVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7H5</accession>
    <name>F4F7H5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RbsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_16550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16550"/>
    <dbReference type="EnsemblBacteria" id="AEB44414">
        <property type="protein sequence ID" value="AEB44414"/>
        <property type="gene ID" value="VAB18032_16550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16550"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OMA" id="IDWKEMR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="282"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="534" mass="57855" checksum="0E8C8EB5284E9DE0" modified="2011-06-28" version="1">METPLPVPDEAQRFAEAPHLRMTDISKRFQGVQALDRVSLLVHSGEIHALLGGNGAGKSTLLNVLSGLVVPDSGTMELTGREVVIGHPREAQALGISTIHQELSTVPDLTVLENIFLGREKALIGNGALLLNRRQIARQIQDLAGEFGITRSELWRPVGEFGALKKRVIEIVKALAVPPRILILDEPTSGLEEHEKTLLFEHMRGLQRRGVALIWVTHHLDEVFGLADVVTVMRDGRTIARTATAELTQRELAVQMFGGDATKLMESADAVAAPRRQAGSECRQPRLRALNLTRRGVLRDISLEVASGEILGIAGLAGAGRTELVRALMGLDKLDSGRIEIDGQARTIRHPKMAYRAGLAMVPEDRKQLGILPDLSVAANITVANLGSVTTAGVLRGRSEQTLADSYIRSLGIRTPGPAEPIRNLSGGNQQKAIIARCLNTRPSILIFDEPTQGIDIHAKAEVHRLVRDVADQGTSVIVIASEFAELISLCDRVVVLNRGALVGEIRDIPHRVATEGYDAVKHAIIDKASRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7H6</accession>
    <name>F4F7H6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase subunit DhaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733075.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16555"/>
    <dbReference type="EnsemblBacteria" id="AEB44415">
        <property type="protein sequence ID" value="AEB44415"/>
        <property type="gene ID" value="VAB18032_16555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16555"/>
    <dbReference type="eggNOG" id="COG2376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_0_0_11"/>
    <dbReference type="OMA" id="MLSAACP"/>
    <dbReference type="OrthoDB" id="857242at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="35230" checksum="0DEDDEB11A17BE92" modified="2011-06-28" version="1">MQKIMGDATTVVPDYLRGLAAAHPGVVEYDPVDRIVVRRAPAAPGKVGLVSGGGSGCEPLHAGYVGLGMLDAACPGEVFSSPVPNQIMAATRRADHGAGVLYVVKNFGGEVMNFGLAAEILRREGVRIEKVLVDDDASFPPELAARRRGLGAAVLVEKIAGAAAEEGRPLDDVAALARRVVGRSRTFGVALSSCTHPKTGRRTFDLPHGEYEVGVGIGGDRGHERRPLPPVDEIADVMLKRIIDELELRPGNQVVVLLSGLGATPAIELYGLFAAVRDRLVKQGVEPVRSLVGDYITSLDSQGALLTVLHADEELLELWDRPVHTASLRWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7P5</accession>
    <name>F4F7P5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium/calcium exchanger membrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_22910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734334.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22910"/>
    <dbReference type="EnsemblBacteria" id="AEB45682">
        <property type="protein sequence ID" value="AEB45682"/>
        <property type="gene ID" value="VAB18032_22910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22910"/>
    <dbReference type="eggNOG" id="COG0387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050648_1_0_11"/>
    <dbReference type="OMA" id="AAVMITC"/>
    <dbReference type="OrthoDB" id="988251at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="37"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="221"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="365" mass="37470" checksum="4D1BA8378BFED8D3" modified="2011-06-28" version="1">MLALRRTLTTWTVSVPIAALVVLALTWNQKLDGIMVVIVGLFLAGAVLAAVHHAEVVAHKVGEPYGSLVLAVAVTVIEVALIVTLMISGGEKTQSLARDTVFAAVMITCNGILGLSLLIGALRRRLAVFNPEGTGGALATVATLATLSLVVPTFTIGRAGPQFSPAQLTFAAVVSLALYALFVMVQTGRHRDYFLPVGSEGETLPEEVHADPPSTRQALISLGLLLVALVAVVGDAKSVSPAIEAGVAAVNLPPAFVGVIIALLVLLPETLAAARAARRDRVQISLNLSLGSAMASIGLTIPAIAIASIWLEGPLLLGLGGTQVTLLALTVITGVLTVVPGRATLLQGGVHLVLFAAFVFLAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F815</accession>
    <name>F4F815_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="7" type="ordered locus">VAB18032_29596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735638.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29596"/>
    <dbReference type="EnsemblBacteria" id="AEB46990">
        <property type="protein sequence ID" value="AEB46990"/>
        <property type="gene ID" value="VAB18032_29596"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29596"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088880_0_0_11"/>
    <dbReference type="OMA" id="FRFGRIV"/>
    <dbReference type="OrthoDB" id="1937493at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="28872" checksum="5C719BDE56F98766" modified="2011-06-28" version="1">MQAASRESYATALARLEEYISRAEPSAVAATGAELLAVADLLRREVRLRRALSDPARAGADRTGLLTSVLSGKVGADTLDLLGTLVAGRWSAPSELLDGAERLGVQALLGSADRADELGEVEDELFRFGQVVAADPQLSNALSDPNAPVAQRAELVGMLLTGKARPATVRLVEAALAGFGGRSFSTALSRLVELAAERRDRQVAYVTVAAPLSEDEERRLSDRLAAIYGRAVAVKLTVDPAILGGASVRVGSDLYDGTILRRLNETRNALAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F821</accession>
    <name>F4F821_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="5">SHMT</shortName>
            <shortName evidence="5">Serine methylase</shortName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glyA</name>
        <name evidence="8" type="ordered locus">VAB18032_29626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735644.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29626"/>
    <dbReference type="EnsemblBacteria" id="AEB46996">
        <property type="protein sequence ID" value="AEB46996"/>
        <property type="gene ID" value="VAB18032_29626"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29626"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_11"/>
    <dbReference type="OMA" id="CATTHKV"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="7">
        <location>
            <begin position="16"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="428" mass="45287" checksum="09DCC29F57D291C3" modified="2011-06-28" version="1">METATGTFWGPDFEQLSTSDPEIAEVVLGELDRLRTGLQLIASENLTSSAVLAALGSTLTNKYAEGYPGRRYYGGCAQVDRAEEIGIARAKDLFGAEHANLQPHSGASANLAAYAALVQPGDTVLAMELPHGGHLTHGSRVNFSGKWFQPVGYTVRRDTELIDYDEVRDLALTHRPKMIICGATAYPRLIDFALFREIADEVGAYLMVDAAHFIGLVAGQAVPSPVPYADVVCATTHKVLRGPRGGMILCRESLAERIDKAVFPFTQGGPLMHAVAAKAVALHEAAQPEYRRYAAQVVANAQALADGLAAEGMRPVSGGTDTHLALIDLQETGVTGAEAEARCDAATITLNKNAIPYDPHKPMVASGIRVGTPCVTTQGMTEPQMRQVAELIARAVRADPSAPGGADVLAGVAADVAELVADHPAYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F830</accession>
    <name>F4F830_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ordered locus">VAB18032_29671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735653.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29671"/>
    <dbReference type="EnsemblBacteria" id="AEB47005">
        <property type="protein sequence ID" value="AEB47005"/>
        <property type="gene ID" value="VAB18032_29671"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29671"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_3_0_11"/>
    <dbReference type="OMA" id="TTDLMGA"/>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="307"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="426"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="438"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="680" mass="74306" checksum="C4F2B5989E177245" modified="2011-06-28" version="1">MSDTTDVTSDVSNVAGDATTAAPARRRRSGTGLSAMLLPELQSLAASLGISGTARMRKGELISAITERQGSAAGAPRPRAEVAAAAAPAREEVHAEVRETGERPEAGRRAAEQPAASVETEGRTRTRRTRATAVAEPRAEEAAAETGERSEGRTSRAAERGGERAAERAERTADRSGERAERGERAAERGDRAERGDRAERAERGDRAERGERAERGAERGERAERGERTERGDRGERAAERGERGDRGERGQRTERDNNTDDDDENGGRRSRRSRFRDRRRGRNERGESGGEGGGREPQVGEDDVLVPVAGIVDVLDNYAFVRTTGYLAGPNDVYVSMSQIKKYGLRRGDAITGAVRAARDGEQRRDKYNPLVRLDTINGMEPDEAKRRPEFYKLTPLYPQERLRLETEPHILTTRVIDLVMPIGKGQRALIVSPPKAGKTMVLQAIANAITHNNPECHLMVVLVDERPEEVTDMQRSVKGEVIAATFDRPPQDHTTVAELAIERAKRLVELGHDVVVLLDSVTRLGRSYNLAAPASGRIMSGGIDSTALYPPKRFLGAARNIENGGSLTILATALVETGSMADTVIFEEFKGTGNAELKLDRKIADKRTFPAVDVSASGTRKEEILLAPEELAIVHKLRKVLHSLDSQASLDLLLDRLKQSRTNIEFLMQIAKSTPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F837</accession>
    <name>F4F837_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42029">
        <property type="protein sequence ID" value="AEB42029"/>
        <property type="gene ID" value="VAB18032_04515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04515"/>
    <dbReference type="eggNOG" id="ENOG502ZNDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_216330_2_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307494" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="42" mass="4637" checksum="9BC2A63BA53F3BB1" modified="2011-06-28" version="1">MFKKLLILVGVVGVAAVVAKKMKEANDERALWHEATTSPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F880</accession>
    <name>F4F880_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Erfk/ybis/ycfs/ynhg family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_10615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731912.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10615"/>
    <dbReference type="EnsemblBacteria" id="AEB43241">
        <property type="protein sequence ID" value="AEB43241"/>
        <property type="gene ID" value="VAB18032_10615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10615"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039404_3_1_11"/>
    <dbReference type="OMA" id="KMVISEQ"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313687" evidence="5">
        <location>
            <begin position="37"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="65"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="254"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="437" mass="46743" checksum="27A63C1D21576100" modified="2011-06-28" version="1">MRVRDQRNRRRGVLAAGMLAVALALTSACTGGGGKGDGNAPGWQGGADQPAAKASVTISEPAADAKNVPAATAITFATEQAEETSVELTDSAGKKVKGALAKDGKSWLPAKALAYGESYTATVTATGDDGLPVTATSAFTVMKQPSKQVRITSFLGDDQTVGVAMPLIVKFGRAIPEKYRPEVQRRMTVTSSPAQEGIWHWVSPTEVRYRPKEFWQAGSKVSYRVQAGGLPLGDGWYGRADLTVDIKIGPKLVMTVDNSTKRMVVTRDGETIKTIPVSLGKKSTPSSSGTMVVMEKLRKTVFDTYDELGPEDGYRTKIDYAQRLTWGGEFIHAAPWSEGQQGTTNVSHGCVNVSMANGAWLFNNTRVGDPIVVKGTERKLQLGNGWTDWNVSWEQYVKGSALPYEPAEDEAADDETADDGTTEDESTDPDVSASAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F899</accession>
    <name>F4F899_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_10710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731931.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10710"/>
    <dbReference type="EnsemblBacteria" id="AEB43260">
        <property type="protein sequence ID" value="AEB43260"/>
        <property type="gene ID" value="VAB18032_10710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10710"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_3_0_11"/>
    <dbReference type="OMA" id="YSWRASG"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307734" description="Beta-xylanase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="9">
        <location>
            <begin position="40"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="8">
        <location>
            <begin position="355"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="476" mass="50833" checksum="33EC276EE9548DF9" modified="2011-06-28" version="1">MDLVHQSGSPRRKRFITATLRTVAAAALAAGFVLAPVTAASAASTLGASAAEKGGRYFGAAVGTYKFNDNTYMTVLNREFNSLVAENEMKWDATEPQRGVFNYSAGDRIVNHARSRGMKVRGHTLLWHAQQPGWAQGLSGGDLRNAAINHVTQVASHFRGQIYSWDVVNEAFADGGSGARRDSNLQRTGNDWIEAAFRAARAADPNAKLCYNDYNTDGINAKSTGIYNMVRDFKSRGVPIDCVGFQSHLGTTLPGDYQANLQRFADLGVDVEITELDITQGGNQANMYGAVTRACLAISRCTGITVWGVRDCDSWRGGDNALLFDCAGNKKAAYNAVLDALNSGSNPNPNPTGNRLRNEASGRCLDVNGASSTNGSQMIIWDCHSNANQQFTQNGRALQVMGKCLDVPSNAGTGTRVQIWDCSGAANQQWVFNSNGTISSAQTGLCLDVNGAATANGSAVIVWSCHGGGNQRWARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8A1</accession>
    <name>F4F8A1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10720"/>
    <dbReference type="EnsemblBacteria" id="AEB43262">
        <property type="protein sequence ID" value="AEB43262"/>
        <property type="gene ID" value="VAB18032_10720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10720"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013864_1_0_11"/>
    <dbReference type="OMA" id="NIWKAPL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312789" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="752"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="882" mass="93994" checksum="DE6356B29B7E39DC" modified="2011-06-28" version="1">MGVLVSAVLPAVVADQAPASAATQATYYVAPGGNDSNAGTLAAPFRTVQRARDAVRAINANMTGDIQVYLRGGTYPVSSTIEFGASDSGTNGYRVSYAAYPGETPVLQGGVQVAGWTQHSGNIWKAPLDRANKLRSLYVNGKRAFMAAKTINSAGCHGSYAITAGQADWAWESGSQCAGARYSQADFPAVAANQEDIEIETATTWTTAIVGVRQVITDGSNRVALFQQPGAAIAQGAFNGNAQINGSHKVMNAYEFLDAPGEFYFDKSSRTVYYYKASSENMATASVFAPNNVATVLRIAGTSTSNRARNITFSGLTVEHSDWNLVNVAGSVFKQAQQGNLSAFAYARGNFHVYHYRNVDVTPGIVHLQNADGILLERNRVQHTGADGINMVNDVINTRLIGNYTNDVAGTAVSVGHPQHVYIGDHTSSNREKYSPQVEGAPRNIEIKNNYIHDSAVLFNGHGAVAAYFVDALTVQYNRIEKAPWAGITMGWGWWNFDGSSGSIVPNRPTTTAKNNTISHNHIIDTVQRLSDTAPIYTLGSQPGTVVSNNYLQGVPAGHKYGLHPDEGSAYMTFRDNVLSVDKNITWMINSDNFGRKHDLTITRTYGPINKVSEKNLPNSTIDDIIVSSDYVWPAAAYQIAVNSGPEESYRDVVQARGVSMQDHVLPASTTAASGVTSIPIRSTGDAARSLWLAPSGTTSFAAGPTMTRADGNATSIAVPTTSGDYRLFVLDAQGNRSAESVSIVRRQGTSSGQSVQLVGGQSGRCIEVPGAATANGTQVQLWDCGAGTHQRWTYTAGKQLTVYGNKCLDAFGNGTTNGTAVIIWDCHGGLNQQWNVNANGTITSVQSGLCIDANGAATANGTKIILWSCNGGTNQQWTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8L5</accession>
    <name>F4F8L5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45758">
        <property type="protein sequence ID" value="AEB45758"/>
        <property type="gene ID" value="VAB18032_23300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23300"/>
    <dbReference type="eggNOG" id="ENOG5032AJS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2995427_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="57" mass="6771" checksum="54BDE29755010467" modified="2011-06-28" version="1">MRDGHDEPAMSRGEQIQAAEREAAKRRLLEQAEAERVPMEETTRAVPDRRWRRDRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8V3</accession>
    <name>F4F8V3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735681.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29811"/>
    <dbReference type="EnsemblBacteria" id="AEB47033">
        <property type="protein sequence ID" value="AEB47033"/>
        <property type="gene ID" value="VAB18032_29811"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29811"/>
    <dbReference type="eggNOG" id="COG3506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082825_0_0_11"/>
    <dbReference type="OMA" id="GLMVRID"/>
    <dbReference type="OrthoDB" id="1485526at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="PTHR35332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="197" mass="21416" checksum="B9820F53290C5C68" modified="2011-06-28" version="1">MVQSIEWSSGNWHQQPVRAVEDADGGLSVEPQADSDLWRHTGYGFVHDYAPALLVDFPVGSAVEVDFRLDYAEQFDQAGVLVRVDDRNWVKTGVEISDGQPQIGAVVTNEFSDWSVAPVPQWAGREVTVRVSRVADALIVRARPAGEPWQLVRLAPLDGDAPAAAGPYCCSPSRGGLTVRFSGWRQGPADATLHPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9E0</accession>
    <name>F4F9E0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ligA</name>
        <name evidence="13" type="ordered locus">VAB18032_11080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11080"/>
    <dbReference type="EnsemblBacteria" id="AEB43334">
        <property type="protein sequence ID" value="AEB43334"/>
        <property type="gene ID" value="VAB18032_11080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11080"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_0_11"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="626"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="109"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB43334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="717" mass="77332" checksum="0A8912176A6ECFA6" modified="2011-06-28" version="1">MAGGGSVSEEASGQPLSAEQEAAAGAEPTPQARERHATLSQELTEHQYRYYVLDAPTVSDAEFDRQLRELTALEEEFPALRTPDSPTQRVGGTFSTDFTPVAHAERMMSLDNAFADEELAAWAERVERDAGGPVPYLCELKVDGLAINLTYQGGRLIRAATRGDGRTGEDVTANVRSIRDVPSRLTDSAEYGPVPEFIEVRGEIYFPVEAFADLNAGLVEQGKAPFANPRNAAAGSLRQKDPRITASRPLRLVVHGIGARKGFQPSTQSESYSALKAWGLPTSDRWRVLPDLTGVRDYIAHYAAHRHDVEHEIDGVVVKVDPVPIQGRLGSTSRAPRWAIAFKYPPEEVNTKLLDIEVEVGRTGRVTPRALLEPVKVAGSTVAYATLHNAREVERKGVLIGDTVVIRKAGDVIPEVLGPVVDLRPPDARPFVMPTTCPACGTPLAPAKEGDVDIRCPNSRSCPAQLRERVFHLAGRGAFDIEALGYKSGAALLDAQIITDEGDLFSLDAEQLARSPFFVNKDGSLGSNATKLLDNLAVARERDLWRVLVALSIRHVGPTAAQALARHFRSIEAIDNASEEELSSVDGVGPTIAASIREWFAVDWHREVVRKWAEAGVRMAEEAVAEGPRPLEGLTVVVTGTLSGYSRDQAAEAIQSRGGKVSGSVSKKTGFVVVGDNPGSKADKAATLKVPILDEEGFQVLLDAGVEAAREVARVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9I4</accession>
    <name>F4F9I4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733217.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17300"/>
    <dbReference type="EnsemblBacteria" id="AEB44562">
        <property type="protein sequence ID" value="AEB44562"/>
        <property type="gene ID" value="VAB18032_17300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17300"/>
    <dbReference type="eggNOG" id="COG2453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047330_5_2_11"/>
    <dbReference type="OMA" id="EQREWTM"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022778">
        <property type="entry name" value="CDKN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05706">
        <property type="entry name" value="CDKN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="4">
        <location>
            <begin position="90"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="169" mass="18197" checksum="DF195DB1800875BD" modified="2011-06-28" version="1">MRLTPTLYRIPTPSPGQLSTMPRPRGDDWLDDEMIALRDLGVDVLVCLLTPTEAAELGLTGEAAAATNAGLEFHALPVDDLGVPDRALAQPLLDLLHDRLTGGRHVAVHCRAGIGRSSLIAAACLLRLGAPLDDVWKVIGEARGVSVPETDEQRHWPLTSHVAPVDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9J8</accession>
    <name>F4F9J8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_17370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733231.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17370"/>
    <dbReference type="EnsemblBacteria" id="AEB44576">
        <property type="protein sequence ID" value="AEB44576"/>
        <property type="gene ID" value="VAB18032_17370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17370"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432074_0_0_11"/>
    <dbReference type="OMA" id="DWTAPDN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="560"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="633" mass="66067" checksum="950C24575B165DA6" modified="2011-06-28" version="1">MDTAWVAAERGGVGALEALQCSDGTTWLVSGGTDHVVQVWQVAQGRATPMLRFTHAAEVLALAVWEGQAGARVACAGSGGDEGGGYLGVWDLVTGAPVAQAWRAHDRWIPDIATWITHDGSVRLVSAAVDGTVRLWDPETGAALGDLTVAGSGPVNALATWTDPAKGARLAGGSEEAGILVWDLDTGALVNRLPASRVWSLAAWTARDGTLRLASGHTDGMIQIVDPESGDVSALSSAGHAGWVHSLATWVTTDDGHRLASASMDGTVRIWDLEIGEPVGQPLTGHIGGSESSMTAWTGPEGHGYLAVAAASGTIRIWDTDAHRVVDEPRTSHSAGVWAVTSWRTSEGRTHLATAGDGGSIRIRDADTGTEVTAPLVGHTAAVWCLVSWFDEHGRIQLASAGDDGTVRIWDPTAGTEQAVLTGHAGWIPALVHWTDSDGRPRLASGGADGTVRVWDPATGAAEQVVDCRPHLRWVLTLAVWPRSDGRTCLGVGGDDGIIRVHVLGDRARPWLSLDGQIGWVRSLTTWTGPDGRIQLASSGVSGLIRIWDAESGTPIGPSLTAHAGAVRSLVTWTDTAGRPMLASAGSNDSTIRRWDLQSGTAVGGPMTGHTGGVWNLDVWTSEDTTSGKSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9K2</accession>
    <name>F4F9K2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733235.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17390"/>
    <dbReference type="EnsemblBacteria" id="AEB44580">
        <property type="protein sequence ID" value="AEB44580"/>
        <property type="gene ID" value="VAB18032_17390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17390"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914287_0_0_11"/>
    <dbReference type="OMA" id="FHRWTRQ"/>
    <dbReference type="OrthoDB" id="1203604at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="309" mass="33939" checksum="C7E8448595BBB676" modified="2011-06-28" version="1">MLVFVTSHKGGTGRSVTAANIAYRSALSGRPTCYLDYDFGSPTAGITFQIPDAVNGVEGAGPNNGGLHRYLRGEIPFPEQLDVWGSSERASLRQRPIGSGPLVLLPGQRNGSEFGFTNDIAKRCAELFLRLEEEFDLTLVDLSAGRSYASQMVLAATATPALRKVVARWLVFHRWTPQHVTAAADLAFEAGGILAMAKEYGHEPERLRESLRFIRTAVIDSRGPEVGHLDLAQQAFLRKCDTELSELARRRGVGRTTLLGAVPLDPLLQWREQLISDHDVQAKIANVKTVDAIVELTEKLFDETAWETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9M3</accession>
    <name>F4F9M3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733256.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44601">
        <property type="protein sequence ID" value="AEB44601"/>
        <property type="gene ID" value="VAB18032_17495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17495"/>
    <dbReference type="eggNOG" id="ENOG5034CGM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1408212_0_0_11"/>
    <dbReference type="OrthoDB" id="1572751at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="21071" checksum="039033C48E7368BA" modified="2011-06-28" version="1">MRLDPVVGAAIADAYMAAPTRDERAYPAYAAFCRETVQQYHFLIGRAEFGGLGISVHIVDVDPYPNVAAMVDDVRQRRLMVWASAASGNAHPYLSDGENDMFRAVHDVFGHAASGRGFDRHGEEAAWWKHSSMYSSLAGRALATETRGQNCARIFRYDPGRFPEQKAVLLPPAFSDPRLVRLTGSAATSAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9P1</accession>
    <name>F4F9P1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733274.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17585"/>
    <dbReference type="EnsemblBacteria" id="AEB44619">
        <property type="protein sequence ID" value="AEB44619"/>
        <property type="gene ID" value="VAB18032_17585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17585"/>
    <dbReference type="eggNOG" id="ENOG502Z93N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570643_0_0_11"/>
    <dbReference type="OMA" id="INHFNQA"/>
    <dbReference type="OrthoDB" id="434836at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="475" mass="53091" checksum="74E31FE7C7B01B9B" modified="2011-06-28" version="1">MSRADRIACEDVVMFVNAAITSTAQREFRSTAAAQRLSLDFLHEYVLGNYRDLYAATLALDVNQLNAAMVVTNLLRTAREASREQRAREGRLIAARLRTLPPQRVYGVFRDLRRLGINNRRTRAIVRDWVAARPDPAFDAVKYRRSLSVAARHAHLPLPGEVGTALFAWRRPRRYETPILEAWRRAHYDQRALYELPYTVAEGLAAQHGIDRARFLSGIAPRLTAGERLRLQGSAVRHKVDGVAMDLATAPLTRLASYALSLPRPERLRRRDELTGALRAAARRAARRQAGTWGRVVAVLDDSYSAAGSGTKRRRPLAVALATHYLLEALAADFTGLWLHHRGDPLLVHPVGATGLGVRILDALERRPDRLVIVSDGWDNDPPGQAAEVLRIWRTRLDPDQHTSIVHLNPVYDADTFDVRRLADGVATVGVRDAEDAAALVELARFATGRAGFDELRRHLADRVERFLDDQEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9X4</accession>
    <name>F4F9X4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 1 extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734552.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24010"/>
    <dbReference type="EnsemblBacteria" id="AEB45900">
        <property type="protein sequence ID" value="AEB45900"/>
        <property type="gene ID" value="VAB18032_24010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24010"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_5_0_11"/>
    <dbReference type="OMA" id="GWLKPSM"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309184" evidence="1">
        <location>
            <begin position="44"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="445" mass="48277" checksum="43601E92E29F3C4D" modified="2011-06-28" version="1">MHPATHPTSAPDGRTYRTPLLRRRLLRGLLAAVVALPLVGAAAACGGDDASDGKTKVSIFWWGGDARNELTVQALDLYTKKNPDVVFETTWQANQGYFDKLATLTAGGNPPDIFQIDDNYLTEYAARNATLDLKKYQDAGDLDTSKFPPSLLQYGEVDGKLAGLAAGENTQGLVYNKTLLDKNGLPEPTTGMSWEEHIAWAEQVSKKTGVPGTQDPSADYKAFWVWLRQQGKDLYSGSDLGFTAEDVTRWFELWKGARDAGATPTPDVIHEGNATDITKQLVVTGKSATSWVWVNQMPELKKNTADELGVIAYPGDPSAQWARASMYWSVFRGSKNADIAVDVINFLVNDPEAVKLLGTDRGLPSNLDLRRVVSDDTTDPAMKQSIEVETKLAETFGEAPQVPIKGHSKVRAELTKAAENAQYGRVTPAEAAAQFVAACKAAIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9X5</accession>
    <name>F4F9X5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, laci family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_24015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734553.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24015"/>
    <dbReference type="EnsemblBacteria" id="AEB45901">
        <property type="protein sequence ID" value="AEB45901"/>
        <property type="gene ID" value="VAB18032_24015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24015"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_11"/>
    <dbReference type="OMA" id="IVFQTFY"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="376" mass="39289" checksum="1656483ABA42BBC8" modified="2011-06-28" version="1">MPVTIRDVARASGVHISTVSRTFSAPHLVNPETRVRVLACAEDLGYRPNRAARALITGRTHNIGLIIADIANPFFPPLIKAAESQARHRDYHVFVADTNEDAAAEEELVHALAKQVDGVLLCSPRMSNSLIEQLSREVPLVVVNRQLAGLPCVLMDVGQGARSAIEHLAGLGHREIALLGGPRGSWTSREIRRAAGAAARTAGAELTVLGPNPPTEHGGLAQAEQVRRAGASAVLAYNDLMAIGLLEGLDALGVAVPQEVSVVGVDDISLSRLTRPKLTTVATPTAAAGRTAVDMLLQHDTDLPRTGRAGGAGTTVGVRRTTAQVMLQTELVIRDSTGPGPYAGRDRPGATAEGPGPHRRADPGGPRVAAGDVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAA0</accession>
    <name>F4FAA0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730835.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05175"/>
    <dbReference type="EnsemblBacteria" id="AEB42161">
        <property type="protein sequence ID" value="AEB42161"/>
        <property type="gene ID" value="VAB18032_05175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05175"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064453_0_0_11"/>
    <dbReference type="OMA" id="DNATPNY"/>
    <dbReference type="OrthoDB" id="902542at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="415" mass="44592" checksum="BE70B90B44172DD2" modified="2011-06-28" version="1">MPTPPPADVIEPHTWTNEIQTRAEFDRRLASGSLVGLTVQGLRLDLDPIPDFTTVEVAGTLFVGCRFASRQVGADLVRRGANVVPPFSGLPYPTQPPHLYTPEELAAGFAEGGFEAMYDARVYAHFRAHGGALPDVREALGQRLHDHGVDNALADATRAWLTAHGPQSVVGVMGGHAVRRGSRSYRMAAVLGRELARANRLVVTGGGPGVMEAANLGAYLSTRPAEDLTAAIDLLATAPDFSDHDRYTAVALRVRELFGRSVTPPPDGTEPATAYQADSTELATGDLDWAHCGGLAVPTWLYGHEPANLFAGRIAKYFSNAIREDTILRLARGGIVFAPGRAGTVQEVFQAATKTYYGTDGASGAYVFLDRAYWTEELPVESLLRPLLATSPFGDLSDTVHLTDDAHEAVRLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAI5</accession>
    <name>F4FAI5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allergen V5/Tpx-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11490"/>
    <dbReference type="EnsemblBacteria" id="AEB43412">
        <property type="protein sequence ID" value="AEB43412"/>
        <property type="gene ID" value="VAB18032_11490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11490"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688508_0_0_11"/>
    <dbReference type="OMA" id="TAWPGHE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="368"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="485" mass="51384" checksum="2F821C928E4D65E4" modified="2011-06-28" version="1">MHGWNDPLDPDATRRPAPPTDDPAWLTDRPAPRSSYLFGDEPESSSDRWYHDQPTEQWHRPHRPAEAGYPAPAHPRWADQDGAGQDGAGQHHRDTAWSTEGHHGAPSHGRHDGGWRADEPTTQVSRWSDQHDGQQPARHAAPDPHHDNQGYDNQGYADTRPPYTGQAPYGAQPYGDQPYGAQLPYAGQQHYGRGDEGQWHGEGSYGVPEDPTARTEAVADASGTDARPSRRRLSRPLVLGGAAAAATLAVSIGVAALALPGNDAPTSTTAGERPVATGPALLETDESVDVLDPLDSPSPSPSPSVSPSAATPSPSPSQAVKPKPTPARSSTAPSRQSAERRGSPSRGATVTASPSNPAGASQAAQVVDLVNAERAKAGCGALTVDEKLTTAAQRHSQDQADNRNMSHTGSDGSDPGERIDRVGYAWRTYGENVAWNQQSPAAVMDAWMNSPGHRANILNCAFTEIGVGVASSNGPYWTQVFAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAJ3</accession>
    <name>F4FAJ3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhoD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732090.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11530"/>
    <dbReference type="EnsemblBacteria" id="AEB43420">
        <property type="protein sequence ID" value="AEB43420"/>
        <property type="gene ID" value="VAB18032_11530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11530"/>
    <dbReference type="eggNOG" id="COG3540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512549_0_0_11"/>
    <dbReference type="OMA" id="VYQHLGN"/>
    <dbReference type="OrthoDB" id="165142at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="143"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="567" mass="63256" checksum="4048597BAA8CC71E" modified="2011-06-28" version="1">MPAELLIGPLLRRVVGTRATVWVETTAPAVVTVRTADGATGTTNTFTAYDHHYALVVVDGLTPDSTTAYQVFVDDQEVWPLPDGRFPPSVIRTRAAEDRDQPVRLLFGSCRETTQHATTRKLPPDALDAYARRILADPDPAALPDLLVLLGDQVYADETSPTVKRLLRRRRRRPAGAPSDQVVSFDEYTKLYLESWGDPEIRWLFSTVPSVMIFDDHEIIDDWNTSASWRADMREQPWWAERITSGLASYWVYQHLGNLSPDEIAADPIFAKVTTAGDATEVLREFGQRVDTEADLAHDIERWQAVQYQWSYSLDLGRTRLVMLDTRCSRVLQPGHRAMLPPGEWSWFVDRVHGDYDHLVVGSSLPWLLPPGIHHVEAWNEKLADSSRPWLAALSERLRRGLDLEHWGAFRRSFDAMGALFARVGGGTPGEPDDRKGAGPAYPPPASINVLSGDVHHSYVARVRFADPTVRTPVHQLTCSPIHNQVPAGMRPLMRLGWSRGPAGATRALARTAGVPRPQVRWRKLAGPYFGNAVATLTHASRTADVVIEGTTNDGHLRQVAHHRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAL7</accession>
    <name>F4FAL7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_17650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733287.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17650"/>
    <dbReference type="EnsemblBacteria" id="AEB44632">
        <property type="protein sequence ID" value="AEB44632"/>
        <property type="gene ID" value="VAB18032_17650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17650"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_1_1_11"/>
    <dbReference type="OMA" id="FATWFVI"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="292" mass="29913" checksum="BE955D7E0CCAFEF1" modified="2011-06-28" version="1">MDRFLFLTLDGLSRGAVYAAFALALVLIWRAGRIVNFAQGAMAVAAAYVAYSVTAATGSYWLGFAAALLAGLLLGAIVDIAVMRLVDHRSPLNPVIVALGLVLLIQAILGMVYGNEYLPAQAPLSRTALTVGDTAVLSPYDLFVFATVGAVGAALVWIFTRTAIGLRMRAAAFAPEVSRLLGVNVGGMLTLGWALASGVGALAAMLVIPTELGLHPHAMDLVFVSAFTAAVLGGLDSPPGAVVGGLGVGLLLSYVSGYAGGDLIPLAVLALLLTVLLLRPGGLFATVTARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAM3</accession>
    <name>F4FAM3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733293.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17680"/>
    <dbReference type="EnsemblBacteria" id="AEB44638">
        <property type="protein sequence ID" value="AEB44638"/>
        <property type="gene ID" value="VAB18032_17680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17680"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097157_0_0_11"/>
    <dbReference type="OMA" id="SHFADME"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="22342" checksum="2424957640914966" modified="2011-06-28" version="1">MVGAETAGRVDGRTARAERTRAAIVEAHLALISEGDLRPTGERIAERAGISLRTLWTNFKDMETLFEASGAELLRQQDAAWRPISPTLPLAKRVDAFCRQRAKLLQLIAPSARAAQMREPFSAQLRRNRLKHIARVRDEIEQLFADELDRAGPARDQVVNAVVAASTWPAWSTLRDGLGLGVDAARAVMARTVGALLAQLDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAX6</accession>
    <name>F4FAX6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734591.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24205"/>
    <dbReference type="EnsemblBacteria" id="AEB45939">
        <property type="protein sequence ID" value="AEB45939"/>
        <property type="gene ID" value="VAB18032_24205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24205"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_11"/>
    <dbReference type="OMA" id="EHMRSEL"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312855" evidence="2">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="298" mass="31739" checksum="CB027CC27F65321D" modified="2011-06-28" version="1">MLDVHRLRIFRSVVASGSVQAAAANLGYTPSAVSQHLTALQRETGLALFARAGRGMRPTAAGHALAAEADRLLARVGEAESLIADLRAGRTGVLTIAYFASVGAAWMPYVVRRIGTELPGVRLNLELREEIPSTREERADLQVVVAPRGFEPGSGFTAHHLVDDPYVAVLPAGHRFADQQEVELAALAEERWVDNDFARGWCRANLIEACTAAGFTPTFGVEAHDYPTALAFVEAGIGPTVLPALGAVRLPDGVTRVGLLRPTPVRSIHLVIHDAVEHTPAVRIAIAALRQVAAGPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB68</accession>
    <name>F4FB68_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_00645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735858.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00645"/>
    <dbReference type="EnsemblBacteria" id="AEB47213">
        <property type="protein sequence ID" value="AEB47213"/>
        <property type="gene ID" value="VAB18032_00645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00645"/>
    <dbReference type="eggNOG" id="COG0688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658706_0_0_11"/>
    <dbReference type="OMA" id="EHNVAAY"/>
    <dbReference type="OrthoDB" id="891720at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="415" mass="43368" checksum="9CF162D99F30798F" modified="2011-06-28" version="1">MTQFPGVRAAGRSGPVRLGERAARTLVAELARINDPKAALLVGAAPESAVLAAAIEALLPGDTLTVVPAESVSPTALREHVSAQGRWVADRVRVVDSLAEAEPAAVVVAGEALAGTAEEARATVETLTKYLADGALLSVATAVGRTAGAAAELERQGALHGVGVDLVLRNPEPVRVFRLRFTPTDAAAAERLAPAYRPSSVPVTRDMHIDSNGVAAAGIALGLAALTRLARPKSKLWLVPALAAAPVAAFFRDPERDVPEDPSAVVAAADGKVLSVQRLHDERFGDGEFLRIAVFLSVLDVHVNRSPVAGKVVDYFVADGGFVNAMKPDAEHNVAAYTVLDTTHGTVVVAQRTGLIARRIVQRAPIGTLLARGERFGLIRFGSRTDVYLPVEAADPLVGPGDKVVGGSTVIARWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB80</accession>
    <name>F4FB80_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component transcriptional regulator, luxr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00705"/>
    <dbReference type="EnsemblBacteria" id="AEB47225">
        <property type="protein sequence ID" value="AEB47225"/>
        <property type="gene ID" value="VAB18032_00705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00705"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="PGRANRH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="225" mass="23589" checksum="B09889454BE6234C" modified="2011-06-28" version="1">MLRLAERPADVVLADTALTRPDSAGFVRRVLARAPQAAVLLLGMEESEAAAATIHAGARGLIQGIDHDLTSAVAKALLLLAAPGRANRHRIADPARDTAAVGGQRPAPNGRPTGDSSPTWTATDAAGSPAMVPVQRGEDPAEPDAEEEKSAARPPRADRSTIGLTERELQVLLGMAEGRSNAEIGRELFVSEDTVKTHARRLFRKLGARDRAHAVAAGFRAGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB98</accession>
    <name>F4FB98_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_00795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735888.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00795"/>
    <dbReference type="EnsemblBacteria" id="AEB47243">
        <property type="protein sequence ID" value="AEB47243"/>
        <property type="gene ID" value="VAB18032_00795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00795"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_0_0_11"/>
    <dbReference type="OMA" id="HMTHFSD"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="240"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="39264" checksum="8A761BAFF5140175" modified="2011-06-28" version="1">MWQAEVRVDLDAIRENVDRMRAGTSAELMAVVKADGYGHGMVPAARAALDAGATWLGVCTLDEALALRAAGIDAPVLAWLLAPGLPLHTGVAADVDLGVASLPQLDEAVEASRRAQRPARVHLKIDTGLSRNGATVADWPALLDAAAKAQADGLVEVVGVWSHFVYADMPGHPTTDRQLAVFHEGLAMVERAGLRPRYRHLANSAATLTRPDTHFDLVRPGLAVYGLSPVAGETHGLRPAMTARARVMLTKRVPAGTGVSYGHTYTTERDANLAVVPLGYADGVPRHASNTGPVQLGGRRRTISGRVCMDQFVLDCGDDPVAAGDVATLFGSGADGEPTADDWAEAVGTINYEIVTRFGSSRVPRVYDGTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBC7</accession>
    <name>F4FBC7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05485"/>
    <dbReference type="EnsemblBacteria" id="AEB42223">
        <property type="protein sequence ID" value="AEB42223"/>
        <property type="gene ID" value="VAB18032_05485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05485"/>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377970_0_0_11"/>
    <dbReference type="OMA" id="GWTVVSW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="647"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="733" mass="78410" checksum="D9B122B3622A640E" modified="2011-06-28" version="1">MRSGSAQGAPQQPIDGSVNDQAQLVAWRRRALEQQLPAAAFPAGTNAPSLVYLLATMFVVVAAVLGFAVNAQHGALPAVVDSQRDIVAKLASSIRLDAAARREELTRMVQTRGETSDAELLNRLISGGRNISGVLIMDAGTRQVIAAKGAELPLDLLPAELPIGSTLAVTNADGPLMVYGIALDETRVVLATQPLTMRNLRLNPDAGHGIHALTPDGTISLMQGANAVEAAHLPAIFEGLVDAGSRQSRQVVVKEWSDRRLLVSSAPVGSSGLVIVSLLTTEVSTGTSLRKGLLLGLSLLAVGLLSFWIMRRSLFLPVRVLLSQAKADACGAITARRPKLRIREAHRIARALALTSGEQFPTDRRWRPTVLQGLSVALVIALLWPAAVVVLGLRAPAPTVPVQLMRDEENRAEEASSALGNLLDGGLVTVSRTSYGFNVQDLEQAGRRLDRELDTDDRLRALYLVDRDGKVLAGAGRRPLRTVEPLPGEIGIHLDRTVQRLPVVYAYNQMADGYSIVGEFDPDRLLGLVRRVSGRTYVVDAELRTVLDSEGFQAFQPLQGDLVREAAVEALPGGTVGRSRTADGKPALVAAAGLSAPGTVAHLEWAVVIEQDTSGLRLPELIEQRWTLLMAGAAVGVVLLTHVWQLYIFVRPLRRLANVADRMSEGNVELPVPPQRHDDIGAIAMCLEICRQVRHTGSARFGGALRLRGAGADRTTVLPRVRSAAGTGRGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBE0</accession>
    <name>F4FBE0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730909.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05550"/>
    <dbReference type="EnsemblBacteria" id="AEB42236">
        <property type="protein sequence ID" value="AEB42236"/>
        <property type="gene ID" value="VAB18032_05550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05550"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_6_0_11"/>
    <dbReference type="OMA" id="MESGRIQ"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="138"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="511" mass="56297" checksum="BFC8FC6FC168677B" modified="2011-06-28" version="1">MRFEPVSSDPRRQPPGATSTAPPLPVANGRHYASMPVPVSAAPTAAEPPPRPRVDFQVVRELRRQLSEQLTRWQRGREFSVDEEDTERARLAVLLVAEYADSVRRAGTPMAAGEERLLLDQVTAELAGLGRLQTLLVDDTIEEVHILGCDQVRITRHGGGVDWVEPIADSDDELVEILQAAARRAGATERSLSTSKPTLDLQLPDGSRLAAVFLVSHRPYAVIRKHNTLDVTLDDLAGTRGDLDEMIDPLLRDFLRASMRAGLNIMVAGLAGAGKTTVIRALMSEIPPDEPYVLLEESRELLPARRTDRHRAVMSFEAREGHGERGPDGRPAGEISIADLIPVSLRMGVLRIIVGEVRSREIVPMLQAMTTSRGSMCTIHARTPGGVSERIIELALAHGREMTVDQARRMAGNALDLIVYVTVEDETGIGGRKHRFVSHVEEVIGVGDSNRITTTKVFAPGPDGRAVPRHLPERVRDQLLRVGYDARLLSRWIEAGQGAWRRPKQTRLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBH4</accession>
    <name>F4FBH4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nad-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730943.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05720"/>
    <dbReference type="EnsemblBacteria" id="AEB42270">
        <property type="protein sequence ID" value="AEB42270"/>
        <property type="gene ID" value="VAB18032_05720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05720"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_0_0_11"/>
    <dbReference type="OMA" id="DAAYCRE"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="360" mass="38866" checksum="3DAC8C7D6DA8E76F" modified="2011-06-28" version="1">MRIVVVGASGNMGTALLRRLRRERDVQVVGVARRLPHAGAGEPYDGVRWHSCDIGLPGAADELTGVFAGADAVVHLAWQIQPSHDQHVLRRTNVDGSRAVVDAVLRARVPALVYASSVGTYAPGPKSAPVSERWPATGVVESSYSRDKAAVEEMLDGIERTHPGLRVVRLRPGLIFQREAGTEIARYFLGPLVPVRLLRYGRLPLVPANRRLRMQAVHADDVADAYARAILGDVRGAFNVAADPVLTPELVARHFHGWTVPVAAPVLRAAAALTWRARLQPIDAGWVELALNVPLMSSHRAETELGWRPRVNAVDALKELVAGMAERAHTDSPPLSATPTLPGRPAGLVRARPAGHSNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBQ1</accession>
    <name>F4FBQ1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">truB</name>
        <name evidence="9" type="ordered locus">VAB18032_11995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732182.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11995"/>
    <dbReference type="EnsemblBacteria" id="AEB43513">
        <property type="protein sequence ID" value="AEB43513"/>
        <property type="gene ID" value="VAB18032_11995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11995"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_0_11"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015225">
        <property type="entry name" value="tRNA_psdUridine_synth_fam2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09142">
        <property type="entry name" value="TruB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="8">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C" evidence="7">
        <location>
            <begin position="237"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="294" mass="30621" checksum="46356E0BBB79BF6E" modified="2011-06-28" version="1">MSTDGLIVVDKPGGMTSHDVVARLRRLARTRRVGHGGTLDPMATGVLVIGVGRATRLLTYVIGADKTYAATIRLGQSTVTDDAEGDVISTAPAGGVTDEAIRAALAALTGEIDQVPSAVSAIKINGQRAYKRVRDGESVDLPARRVTVSRLDVLAIRRDQPDLVDVDVEVACSTGTYIRAIARDAGLALQVGGHLTALRRTAVGGFTLAEAATLDELEQRAPEVVDLPLAAAAARFFTRRDASPDEAKVLSHGGPLDAVGHAGPYAVFDPAGQLIAIVSERAGRARAEIVLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBT0</accession>
    <name>F4FBT0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733385.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18140"/>
    <dbReference type="EnsemblBacteria" id="AEB44730">
        <property type="protein sequence ID" value="AEB44730"/>
        <property type="gene ID" value="VAB18032_18140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18140"/>
    <dbReference type="HOGENOM" id="CLU_2940551_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="60" mass="6569" checksum="AE85F15551DB7521" modified="2011-06-28" version="1">MSELWRRLGRPVARVLAAYGWYSALTHPMGPPMPRSPRRPLPPAAGRPDPVDERGGLGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBW2</accession>
    <name>F4FBW2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 11 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733417.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18300"/>
    <dbReference type="EnsemblBacteria" id="AEB44762">
        <property type="protein sequence ID" value="AEB44762"/>
        <property type="gene ID" value="VAB18032_18300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18300"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057148_1_0_11"/>
    <dbReference type="OMA" id="WWGGMWA"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="29243" checksum="6A178857612AE2CC" modified="2011-06-28" version="1">MPAAPNVYTHGHHESVLRSHRWRTAENSAAYLLPHLAPGSSVLDVGCGPGTITVDLAARVAPGRVTAVEITDDALQLARTEADARGQGNIDFAVADVHALDLSDGTFDVVHAHQVLQHVADPIQALREMRRVCRPGGIVAARDSDYAAFTWFPRVPALDDWLALYQQAARANGGEPDAGRRLLSWAHAAGFTDVRATASTWCFATPEDREWWGGMWAERILNSDLARQVLAAGVATAQDLRNISDGWREWAEAADAWFAVLHGEIVCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC14</accession>
    <name>F4FC14_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24570"/>
    <dbReference type="EnsemblBacteria" id="AEB46012">
        <property type="protein sequence ID" value="AEB46012"/>
        <property type="gene ID" value="VAB18032_24570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24570"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_1_0_11"/>
    <dbReference type="OMA" id="MDHLWST"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="131" mass="14699" checksum="59DB87A5F133CB20" modified="2011-06-28" version="1">MSRDRRKDPGNDRPLGPLEAAVMDALWAATEPLTVRQMVDAMADRRLAYTTVMTVLDNLHRKGWADRDLAGRAYRYRPRASREEHVGQLMAEALSSAADQHAALARFVDAMRPEEAAALRELLDQRGRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC37</accession>
    <name>F4FC37_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24685"/>
    <dbReference type="EnsemblBacteria" id="AEB46035">
        <property type="protein sequence ID" value="AEB46035"/>
        <property type="gene ID" value="VAB18032_24685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24685"/>
    <dbReference type="eggNOG" id="COG1944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056369_0_0_11"/>
    <dbReference type="OMA" id="CHLHPEI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="2">
        <location>
            <begin position="67"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="408" mass="44442" checksum="C337CD33DA80ECF6" modified="2011-06-28" version="1">MEAGTDKTYRDGTDRAIAPAETWQRVLPRLPEMGITRVADVTGLDHIGVPVFMAVRPNSRGLTVAQGKGLSVDAARVSAVMESIEAYHAERIEAPLLLGSWDELARHRRLVDTSFLITAAGEPLRRDRRLLWIEGTDLMSGEPVWLPFDLVHNDYTGASQAGQSPFAVTSNGLASGNHLLEATSHAICEVIERDAEALWLATPKQRQDELRVDPDTVDDPACRYVLDTLAAAGVAAACWDMTTDIGLPCFTVDIAEDPRVSISRVAVAQGQGCHPRREIALLRALTEAVQSRLTVIAGSRDDFYRSLYARANDLDNREAAWRTCAAGNAPRHFTDVPTRDNGSFQEDIEHELAALRQAGITEAIQVPLGGEQLGISVVRVMLPGAEHAPTPDTYHPGPRARRLREAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC44</accession>
    <name>F4FC44_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734694.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24720"/>
    <dbReference type="EnsemblBacteria" id="AEB46042">
        <property type="protein sequence ID" value="AEB46042"/>
        <property type="gene ID" value="VAB18032_24720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24720"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_2_11"/>
    <dbReference type="OMA" id="NEGVGYF"/>
    <dbReference type="OrthoDB" id="543793at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="6">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="526" mass="55823" checksum="B2C7DF36774EFA47" modified="2011-06-28" version="1">MYDYVVVGAGSAGCVIANRLTEDPDVTVCLIEAGGDDSAPNIKVPAAFSKLFRTEYDWDYSTHDEPALAGRRVYLPRGRGLGGSSSINAMVYVRGDRTDYDGWGQPGWSYDELLPYFLRSEDNERGASPYHGVGGPLRISDGRSRNVSCGAFIEAATEAGYAANDDFNGPQREGFGFFQVTQRDGRRWSTADAFLRPALDRPNLVVETNLQVHRVLISGGRATGVTGRRHGAEVTIEAGREVILAAGAYNSPHLLMHSGIGPADLLRALGIEVVLDQPEVGQNLQDHVLIPLNYVHSQPVSLLVSGAPENVQLFMEQGQGPLCSNGPEAGGFVRTRADLPGPDVEFFAAPIMFVDSGLAPPTAHALSCGPVLLTPASRGAVTVASDDPTAKPRIQHNYLTDPADVETAVAAVRIGMEIARQPAMRPYAESLDRAPASESDRDLADYARRYAHSIFHAAGSCALGRVVDPQLRVLGIDGLRVADASVLPTVTRGNPHASVIMVGEKAADLIRGGATVPVPATAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCD7</accession>
    <name>F4FCD7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplC</name>
        <name evidence="8" type="ordered locus">VAB18032_01160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01160"/>
    <dbReference type="EnsemblBacteria" id="AEB47316">
        <property type="protein sequence ID" value="AEB47316"/>
        <property type="gene ID" value="VAB18032_01160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01160"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_11"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="207" mass="22021" checksum="79A01C335A018816" modified="2011-06-28" version="1">MTQVWDNNKVVPVTVVQAGPCVISQVRDADKDGYSAVQLAYGTIDPRKAKKPLRGHYAKADVAPRRHIVELRTSDAADYSLGQEITVEEFPAGISIDVTGKTKGKGYAGPMKRHGFHGLRASHGVERKHRSPGSIGACATPGRVFKGTRMAGRMGGVRYTVQNLTVQAVDTENNLLLVRGAIPGPKGALVLVRTAAKTKAKKGGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDF5</accession>
    <name>F4FDF5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin biosynthesis-like protein MoeZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_01410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736002.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01410"/>
    <dbReference type="EnsemblBacteria" id="AEB47366">
        <property type="protein sequence ID" value="AEB47366"/>
        <property type="gene ID" value="VAB18032_01410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01410"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_1_1_11"/>
    <dbReference type="OMA" id="MIYDALE"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="301"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="42345" checksum="1F1F201A43C14B6B" modified="2011-06-28" version="1">MSLPPLVEPAAELTVDEIRRYSRHLIIPDVGVTGQKRLKNARVLCVGAGGLGSPALMYLAAAGVGTLGIIDFDTVDESNLQRQIIHGVSDIGRSKAESAAASIREINPLVNVEIHNTALDRDNVREIFAQYDLIVDGTDNFATRYMVNDAAVLLGKPYVWGSIYRFDGQASVFWAEHGPCYRCLYPEPPPPGMVPSCAEGGVLGVLCASIGSIQVNEAIKLLAGVGEPLVGRLMVYDALEMSYRKIKVRKDPNCVLCGENATLTDLMEDYEDFCGAVSVEAQEAVVDSTITAAELKEWQDAGKDIFLVDVREPAEYEIVRIPGATLIPKGEILSGEALAKLPQDKQVVLHCKSGVRSAEALAALKAAGFRDAVHVQGGVLSWIKQIDPSLPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDG9</accession>
    <name>F4FDG9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736015.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47380">
        <property type="protein sequence ID" value="AEB47380"/>
        <property type="gene ID" value="VAB18032_01480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01480"/>
    <dbReference type="eggNOG" id="ENOG5031K7Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076067_0_0_11"/>
    <dbReference type="OMA" id="AYEMLNG"/>
    <dbReference type="OrthoDB" id="1831297at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307818" evidence="1">
        <location>
            <begin position="38"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="27895" checksum="88374263B20E1981" modified="2011-06-28" version="1">MTQRTGITVTGRRVAVTAVALLTVALVAGCDDETPQAAPPPPDPKQELLAAVPTDEDPAFRFTTSDTSGDVSGVIDPANQGMDIDTVTKDKDFTLEMSFRMVDSRTWMKVNFKGSKDIQKLMKLPTKWMEMDPAKLDGPDTLPTYQGTDPGNAEVIIRAASDVQAGEAGSYTGVIDPTDQPDLADALEGIATLGDAAEPIPFTAVVGADGNLTTLTLKIPAAGKKKASEYVVEYYDFGTTPPIAALTPDEAQKAPTSAYDLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDP4</accession>
    <name>F4FDP4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PSP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06415"/>
    <dbReference type="EnsemblBacteria" id="AEB42407">
        <property type="protein sequence ID" value="AEB42407"/>
        <property type="gene ID" value="VAB18032_06415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06415"/>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033149_2_0_11"/>
    <dbReference type="OMA" id="YGGLGPC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="57"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="31533" checksum="0374E8E28934BA24" modified="2011-06-28" version="1">MLCAVSFQRYGRLYYLDPGELRPQVGDKVLVPTDDGPEVAECVWAAQWVTEDTDGFPKLAGLAQDEDLRRDEDLRRRKAAAKVAAKRLIREHGLPMKVVAVDHVLSRGDDGGERSTIYFTAPHRVDFRSLVRDLGATLHCRVELRQLSARDSARVQGGIGSCGRDLCCATFLNDFEPVTIRMAKEQDLPLNPLRISGACGRLMCCLKYEHPLYASSGTYPASGQRVETPSGLGKVVSRHPPSETVTVRQLSDGSVNRCSLADVCRPRIAYDERPPSAEPGGLSPQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDZ1</accession>
    <name>F4FDZ1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732340.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12790"/>
    <dbReference type="EnsemblBacteria" id="AEB43672">
        <property type="protein sequence ID" value="AEB43672"/>
        <property type="gene ID" value="VAB18032_12790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12790"/>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099864_1_0_11"/>
    <dbReference type="OMA" id="NWIATRG"/>
    <dbReference type="OrthoDB" id="1624386at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313830" description="Peptidase_C39_2 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="49"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="22605" checksum="FB6C7F2BE424A2E4" modified="2011-06-28" version="1">MRTTLLRKTALTFAAAAATAGGIAGPAVAAHAAPAGVQADRKPSDERQLDVRYEAQPNFYFCGPAAARNALSVQGKNIDVYDMAERMGTTEAGTDSINDITPVLNKETGKDVYKSVEIRDAKAAEKQTDKLREDIKRTVDDGRAVVANIAGTATDTDGVAHSFEGGHYVSVTGYDDEGKTVTIADSANPAQASYQMDIKTLANWIATRGYSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE23</accession>
    <name>F4FE23_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733547.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18950"/>
    <dbReference type="EnsemblBacteria" id="AEB44892">
        <property type="protein sequence ID" value="AEB44892"/>
        <property type="gene ID" value="VAB18032_18950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18950"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056519_1_1_11"/>
    <dbReference type="OMA" id="YHMPFPA"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="76"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="34368" checksum="142B068E1AD9C8CA" modified="2011-06-28" version="1">MTNPQPDTTPRWQDTGGGDGPLWSFSVGDVEVFPIREVDYFPLPTDFFPQLATESWTDGAFYTAEPWTRDGRIVLNQEAHLLKTRDRLILVDAGGGNGKPRNGGVFDRADRPFLEQFARAGVSVDDIDTVVFTHLHVDHVGFATSSDGAGGWVPTFPNARYLVVREEYDWWTGPEGAAAMARTGDYLADSILPLRDAGVLDLIPADHVISPEIHLVPAFGHTPGNVYLVVESAGRRALFAGDMLHHGVQLERPEWSIRYCVVPGDSADQRRRLLERVAGSGDLLVPTHFPFPAAGYVHRAERGFTYTFIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE68</accession>
    <name>F4FE68_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_19175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19175"/>
    <dbReference type="EnsemblBacteria" id="AEB44937">
        <property type="protein sequence ID" value="AEB44937"/>
        <property type="gene ID" value="VAB18032_19175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19175"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046383_0_0_11"/>
    <dbReference type="OMA" id="QRAFPPI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026281">
        <property type="entry name" value="HTH_RamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018653">
        <property type="entry name" value="ScfR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09856">
        <property type="entry name" value="ScfRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019251">
        <property type="entry name" value="Rv0465c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="474" mass="53389" checksum="6EF734C6645E8006" modified="2011-06-28" version="1">MTRQNLLAWEVRTISKTFAGARLRRLREERALSQTELARHLGISPSYLNQIEHDTRPLTVPVLLRITELFGVDPTVFAAHDTPRLVTGLREALPNRASPAELTELATRLPELAAAVIDLHRRYQQAEEQLAELVGDRERLGRSPHDQVTEFFYRRQNYVPEMDEEAERLAAAMGLRRGEVRGRLRDRLAQRHGVRILREDDGALGGELHRYRPQTRTLHLSTSLRGGQEAMRMAAQIALLEFADVIDEIVESENFDDPQTQILTRVGLANYFAAALILPYDQFLTAAEQRRYDIELLTQHYAIGWETVCHRLSTLQRPRARGVPFSFVRVDRAGNMSKRQSATGFPFSRTGGTCPLWNVYEAFGAPGRVVTQVAAMPDGQRYLWIARTITRHHGGYGQPGKVYAIGLGCETRHAGRLVYSTGVDLHAAEAATPIGPGCKTCDRMTCPQRAAPPISRPLDLDENRSTFIPYPLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE85</accession>
    <name>F4FE85_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_25265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734803.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25265"/>
    <dbReference type="EnsemblBacteria" id="AEB46151">
        <property type="protein sequence ID" value="AEB46151"/>
        <property type="gene ID" value="VAB18032_25265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25265"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_20_1_11"/>
    <dbReference type="OMA" id="VHNAGAF"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="497" mass="51293" checksum="FCD6D954EDE8AEA5" modified="2011-06-28" version="1">MSHSKPDTVSAVLARGRLGIPSVVFFVIAAAAPLTVVAGGATTGYAVTGVTGIPVSYLLVAAVLALFAVGYVAMSRRIVNAGAFYTYVTRGLGRPAGVGAAMVALLAYNAMQIGLYGGAGAVTAQFLNDRYGVGLTWWSCALAVWAVVAVLGVARIDLNGRVLAVVLVAECVVALTFDAIMVTHPADGTVSFDTLAPSHVFAAGIGAALVTAITGFVGFEGTVVFSEETKDPRRTIARATYIAVAVTGLLYGLSAWAMSVATGPDRIVAAARADGTDLIFNLVSPYLADSIVTVARVLFITSLFAALLSFHHTVARYLFALGRERVLPAVFGRTSRRTGAPKVGSLVQSGLAFAVLVGYAVAGADPIVHLFFWVTVTGGLGVLILMTVTSAAVIGFFARSTHTEGPWRSLIAPGLATVALGGILTVTLREFATLLGVAPDSPLRWAFPAAYAAVALLGVAWALLLRTTNPDVYAAVGLGADRDTGPLRAPDTVRQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEA0</accession>
    <name>F4FEA0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734818.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25340"/>
    <dbReference type="EnsemblBacteria" id="AEB46166">
        <property type="protein sequence ID" value="AEB46166"/>
        <property type="gene ID" value="VAB18032_25340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25340"/>
    <dbReference type="eggNOG" id="ENOG5031S3V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1739738_0_0_11"/>
    <dbReference type="OrthoDB" id="1789148at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="16705" checksum="AF195E0092D9ED5C" modified="2011-06-28" version="1">MAVEFRLVLAGDPPVAEVAALTAADPREVPRPASNPALFSARLYEQRGYAITVRAGTDGYWEAEADGETRWEWAPTSYVSVTFSMRADDIVEKGIPNMMAAVTRVLAGRDEDAALVQDGNYLLLTRTDGVVHTYRPDWWDHYHLDRSFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEN4</accession>
    <name>F4FEN4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_01960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736110.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01960"/>
    <dbReference type="EnsemblBacteria" id="AEB47476">
        <property type="protein sequence ID" value="AEB47476"/>
        <property type="gene ID" value="VAB18032_01960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01960"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OMA" id="QYIYQMA"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="93"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="335" mass="37379" checksum="EBBB2C4391F73836" modified="2011-06-28" version="1">MALQLDARGPTAPAPGRSRLLRAGRLSRIDAKYSPYLYIAPFFVIFAIFGAWPLAYTFWVSLHDWDLLGSNPTFIGADNYTRLLADGDFWHSVVNTLGIFVLSTVPQLLLALWLANLLNRQLRMRTGWRMAVLVPNVTSTAAVAIVFGVLFGREFGMINWLLDLVGIDGIEWKSNRFASWVAISTMVDWRWTGYNALIFLAAMQAIPRDLYEAAAIDGANRARQFWSVTVPLLKPTIIFCVIISTIGGLQLFTEPRLFHSGTNAIRGGPLRESQTMTMYMFENAFAPYYNFGYGSAVAWLLFALIAIVAAINVLIIRRLGSSARPPEGNRKGGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEP3</accession>
    <name>F4FEP3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold-shock DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731110.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06565"/>
    <dbReference type="EnsemblBacteria" id="AEB42437">
        <property type="protein sequence ID" value="AEB42437"/>
        <property type="gene ID" value="VAB18032_06565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06565"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125944_0_0_11"/>
    <dbReference type="OMA" id="QRVEFGM"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="128" mass="14079" checksum="368DEB2A1DDA7D1D" modified="2011-06-28" version="1">MPTGRVKWYDATKGYGFVTSDEGGDVFLPKAALPAGVTDLKGGQRIDFSVVDSRRGTQAMGVKLLEAPPSVAELRRRPAEELHGLVEDMIKVLEAKVQPDLRRGRFPDRKTAQKIAQLVHAVARELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEW8</accession>
    <name>F4FEW8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ligC</name>
        <name evidence="4" type="ordered locus">VAB18032_12830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12830"/>
    <dbReference type="EnsemblBacteria" id="AEB43680">
        <property type="protein sequence ID" value="AEB43680"/>
        <property type="gene ID" value="VAB18032_12830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12830"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_4_1_11"/>
    <dbReference type="OMA" id="AGFRWHK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="137"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="385" mass="42901" checksum="A94FCC9885D0EA41" modified="2011-06-28" version="1">MICLTVVGGVWLTVAVDLPINPPVEPMLARSVASIPTGPGMTYEPKWDGFRCIIFRDGDEVELASRGGKLMTRYFPEVVEQARRQLPARCAVDGELIVIRRDSPNAAPRLDFELLAQRIHPAASRVKLLAETTPADFVAFDLLALDGESLLDVPYPTRRARLEQALAKVRPPVHVTQITTDADTARRWFDVFEGAGLDGLIAKPADLPYEPGKRLMFKVKHARTADVVVAGFRWHKSGPVVGSLLLGLYDDAQVLHHIGVSASFTMARRAELLEELAPYREVGAEHPWVHGDHERGQRIPGGVSRWTGTKNLEWEPLRPELVVEVAYDAMEGDRFRHTARFVRWRPDRDPLSCRYDQLDRPVRFDVDQVLRGDPTVTVGSGTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEY1</accession>
    <name>F4FEY1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732361.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12895"/>
    <dbReference type="EnsemblBacteria" id="AEB43693">
        <property type="protein sequence ID" value="AEB43693"/>
        <property type="gene ID" value="VAB18032_12895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12895"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_1_2_11"/>
    <dbReference type="OMA" id="HACPVCE"/>
    <dbReference type="OrthoDB" id="1143316at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="619"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="824" mass="87336" checksum="41AFD730F6D6A1D9" modified="2011-06-28" version="1">MRPMRLDLAGFTVFRDETTIDFTDADFFALVGPTGSGKSTVLDAICFALYGTVPRWGGTRGLGNALAPSATEARVRLVFESAGARYVATRVVRRDGRGNVKTANAGLQLMPDGFDVTKLDTGLSPEDLGEVVAGTPGEMDEAVLAAVGLPYEQFTSCVVLPQGQFADFLHARPATRQQILVNLLGLGVYEQVQQRATGRAAQAEAKLEAVDQLLAGLADTDDATLERATEQVERMTELATAVTAAVPELETARATAREVMQALAALDAELSVLDAVRAPDGTAELTQAVAAARAAADAAVDAVSLAEEREEKLRGELTALGDESTLRLQLRSYAEREQLAGQADALRAAVQAAGAEHDAAVAALAQATAAAERAEAELAAAFQAHEEAKTADQAAALRAHLSDGDACPVCEQVVARVPAVPAGSAVARAVAAGKSARAASEAAKRLVVERDAAARDLDRVLVRTRAEHDGIQARLSALDELLADAASAQTLRERLDEHTRLRAALDEAATAVRAGRDAARRARGTVDAAQERLRTAWRHFDGTRDGLARFGPPAADRDDLAAAWATLAEWAQEQARQRRSQRDGLATSVADAEAATRAVAARIDGIFADAGLPAPDDPVRAATVAVERAEAELRRLVERREQAAELREQRAEHERQAQVARALAGHLRANNFERWLLAEALDLLVDGASGILRELSGGQYDLIHDKGEFFVVDHHDAGLRRGVRTLSGGETFQASLALALALSEQLAGLSTTAASLESIVLDEGFGTLDAATLDTVAATLENLAARGDRMVGVVTHVPALAERIPVRFEVRKDARSARVERTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF04</accession>
    <name>F4FF04_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal L11 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732384.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13010"/>
    <dbReference type="EnsemblBacteria" id="AEB43716">
        <property type="protein sequence ID" value="AEB43716"/>
        <property type="gene ID" value="VAB18032_13010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13010"/>
    <dbReference type="eggNOG" id="COG3897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074455_1_0_11"/>
    <dbReference type="OMA" id="ILNCELN"/>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="222" mass="23628" checksum="7F41DAB0079F59FD" modified="2011-06-28" version="1">MSALSTAFVRLHARLAPVAFVPEVRLHQADEPIGLWELTEGEFRSDQPPPFWAFAWAGGQGLARYVTDHPQLSAGRRVLDLASGSGLVAIAAARAGAAAVRAVEVDPLAVAAITLNAEANGVRVDAELADILDGEAGDAEVIFAGDVFYSAAMTNRVLRFLLRAARGGAQVLVGDPGRAFLPRDRFDELASYDVPVSEALESVRVKRTTVWQLRAGRPEATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF38</accession>
    <name>F4FF38_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase, g6pdh family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732418.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13180"/>
    <dbReference type="EnsemblBacteria" id="AEB43750">
        <property type="protein sequence ID" value="AEB43750"/>
        <property type="gene ID" value="VAB18032_13180"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13180"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_4_0_11"/>
    <dbReference type="OMA" id="LMTEQSG"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="35117" checksum="BDD861B0606F8FF3" modified="2011-06-28" version="1">MVNIGYTLMCEQAGPKELVDYAVRAEAAGFDHIVTSDHYYPWLESQGHSPYAWSVLGAVAHATSRAELMSFVTCPIRRYHPAVVAQKAATIGVLSDGRFTLGLGAGENLNEHIVGAWPHVQQRHEMFEEALQIIRPLLGGETLTFSGNHYDVPDAYIWDRPDAPVPMAVAASGRQSATLAAEYGDAMVATDPEARLVEMYEQAGGAGRPRYGQVAICYGPDEAECRKIAHDQFRWFGLGWKVNTDLPDNDAFEAATRSVREEDVAAGISCGPDVDKHVEAFKKFVDAGFTHVALVQVGGDSQPMFLDWAQEQLLPRLRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF77</accession>
    <name>F4FF77_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733637.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19400"/>
    <dbReference type="EnsemblBacteria" id="AEB44982">
        <property type="protein sequence ID" value="AEB44982"/>
        <property type="gene ID" value="VAB18032_19400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19400"/>
    <dbReference type="eggNOG" id="COG1118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="HLGWEIQ"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102025">
        <property type="term" value="F:ABC-type thiosulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03296">
        <property type="entry name" value="ABC_CysA_sulfate_importer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005666">
        <property type="entry name" value="Sulph_transpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00968">
        <property type="entry name" value="3a0106s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="335" mass="36563" checksum="D0E5593BFEFC96B6" modified="2011-06-28" version="1">MSIEIVNVGKRFGDFVALDDVSVSIPSGRLTALLGPSGGGKSTLLRIIAGLERADTGKVEIEGVDATGLPPQKRNVGFVFQHYAAFKHLTVRRNVAFGLEIRKRPKDEIRRRVDELLALVHLEQFAERLPAQLSGGQRQRMALARALAVEPTVLLLDEPFGALDAKVRKELRDWLRRLHDEVHVTTVFVTHDQEEALEVADEIVVINEGRVEQIGSPDDLYDRPANEFVMRFLGPVTQLGDQLVRPHDLHLSAGGTAGVAARVTRVTRIGFEIRVDVATTGGQPVTVTLTRNEFLALGIAVDSEVRVQLAPGSPSTTVSTPEQRTAEPSLATTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF78</accession>
    <name>F4FF78_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733638.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19405"/>
    <dbReference type="EnsemblBacteria" id="AEB44983">
        <property type="protein sequence ID" value="AEB44983"/>
        <property type="gene ID" value="VAB18032_19405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19405"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_1_1_11"/>
    <dbReference type="OMA" id="GADWTIM"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="173" mass="18253" checksum="16D8D8342BF0F789" modified="2011-06-28" version="1">MAPPTDDLKPVDADVAELRNLLRHQASTVTVVTAPGPPLAGFTATSFSAVSLRPPVVSFCVDTGSSSWPTMAAARHVGVHLLAHDQHQLARTFATSGIDRFAAPTRWQPGPEGVPVLADALAWLLCRVIDRVRVGSHAIVLAEPELLHSAGVGSPLLYHRGRYTGLPAAHVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFA1</accession>
    <name>F4FFA1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733661.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19520"/>
    <dbReference type="EnsemblBacteria" id="AEB45006">
        <property type="protein sequence ID" value="AEB45006"/>
        <property type="gene ID" value="VAB18032_19520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19520"/>
    <dbReference type="eggNOG" id="COG4214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_0_11"/>
    <dbReference type="OMA" id="FDVWNKR"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="416" mass="43507" checksum="9829D4C9123FBCB6" modified="2011-06-28" version="1">MTSTKPSSVHKGGSTESTPADALHVGSSDPRTLIMNNLRQSGIFVALVVIVALFAFLTDGLSLSPGNITNIVLQYSYILVLAIGMVIVIIGGHIDLSVGSVVALTGAVSAVVVIRQGQPWWLGVLAAVAVGLAVGAWHGFWVAYVGIPAFIVTLAGMLLFRGLTLRVLDNISLSPFPAEYNRIAAGFLNGLIGGDGYDAFTLLIGGIAVAGYVVSCFRTRVARIRYQQPVESFALFVARMVLVGAVVMWFAWQLANARGLPIVLIILAVLVLVYGLLTRRTVFGRQVYAIGGNLPAAMLSGVKVRTVNFWIFVNMGFLSAVAGVIFSSRSNGAQPAAGNMFELDAIAAAFIGGAAVTGGVGTVVGAMVGGLIMAVMSNGMQLMGVDQSMQSVVKGLVLLVAVAFDVYNKRRAGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFE8</accession>
    <name>F4FFE8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25760"/>
    <dbReference type="EnsemblBacteria" id="AEB46250">
        <property type="protein sequence ID" value="AEB46250"/>
        <property type="gene ID" value="VAB18032_25760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25760"/>
    <dbReference type="eggNOG" id="ENOG5033C84">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208507_0_0_11"/>
    <dbReference type="OMA" id="MRSIWKW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="58" mass="6505" checksum="5EF45A242B6C1D85" modified="2011-06-28" version="1">MRWWKVLGLAGLAGVAASGVVIARAERRRRAYSPEEIRDRLRNRHAEANSFSPAGEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFM9</accession>
    <name>F4FFM9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Winged helix family two component response transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736140.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02110"/>
    <dbReference type="EnsemblBacteria" id="AEB47506">
        <property type="protein sequence ID" value="AEB47506"/>
        <property type="gene ID" value="VAB18032_02110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02110"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125428_0_0_11"/>
    <dbReference type="OMA" id="RLWSYER"/>
    <dbReference type="OrthoDB" id="1865799at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="61"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="172" mass="18734" checksum="E2CFA472CAE0E7CF" modified="2011-06-28" version="1">MSGVEIPILVCVSSDAAVRQRVVQRLDGVGPVVICADLAQLRAMFPEPPGEPDLTDVRPPERRPDAADGWLDLVIDRAGHLVSWRGVPLGLTRTERELLARLASSPVSLWSYERLFASVWGGAYLGDTAILHSAVKRLRRKLRALPGGPQVQTVRGVGYRLTAPPDAVEDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFT3</accession>
    <name>F4FFT3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_06945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06945"/>
    <dbReference type="EnsemblBacteria" id="AEB42513">
        <property type="protein sequence ID" value="AEB42513"/>
        <property type="gene ID" value="VAB18032_06945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06945"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="OMA" id="WNFPLMF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="23"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="485" mass="50835" checksum="C5462692D94D74EC" modified="2011-06-28" version="1">MSQPPTHLLPEPALWIGEERVVDSSGGRTDHVYAATGQPTTQVVLAGPAEIDRAVTLARESLPRWRDSSAEVRRDALLRLADLLLVHAESLAALQSLEIGLPIQLARRLPALAADHLRYYAGWCDKIGGEVLPTWPGRSLDYTLDEPFGVVAGIIPWNGSLMSMAQLLGPALAAGNAVVVKPSELAPFVGPRFAELAVQAGVPRGVVVVVPGGPSAGAALAGHPGVDKVHFTGSGATGRQVLAEAARNLTPVALELGGKSPHLIFDDADLRSAARYAMSGVVALSGQGCANGTRLLVHSAVRDQVLQTLTARLRRVRVGDPADETTVMGPVVSGQACDRIIGVIDRARTAGAQLLVGGGRCGGDLADGFFVEPTVFVDADRDTELVQEEIFGPVLAVSSFDTEDEAVELANATRYGLGAYLHTNDLRRAHRISRAVAAGSVWVNGAPGLMPSAPFGGVKQSGSARIGGLAGLREFLRPKNVWIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGB5</accession>
    <name>F4FGB5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/h+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_19755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19755"/>
    <dbReference type="EnsemblBacteria" id="AEB45053">
        <property type="protein sequence ID" value="AEB45053"/>
        <property type="gene ID" value="VAB18032_19755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19755"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_2_11"/>
    <dbReference type="OMA" id="AGMMMNY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="7"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="523" mass="56681" checksum="5014F1FCB1672FEA" modified="2011-06-28" version="1">MQELLLIIVLGITVLIGTTVGGRYRVAPPVLLICFGALLGLLPPFSHVMLAPEVVLLLFLPAILYRESLTTSLREVRANITVIAMLAVVLVGLTMVAVSLVVQRFGIDPAVAWVLGAVLAPTDAAAVAGLAKQMPRRLLTTLHTESLINDGTALVLFAVALGLLGGGAAPNAFELVERIGLSFLGGIAAGLLVGIVVIGIRKHLDDPLREGAVSVLTPFAAFFLAEAVHESGVLAVVVAGLILAYASPRVIRARSRVLALSFWDLTTFLINGGLFVLVGLQIPRAVSDVTSLALTRALLIAVVVAVVLVAVRMLWVHAMALILRLVDWRKVHLDRRVNWRVRTVAGWAGFRGAVSLAAALAVPMSIDGQPVPERDLIIFCVAAVILLTMLVQGTTLPLVMKWARLTGDPDRTDEKRQAQRHAIRQTLHALPDLADRVGADPDTMRRIQDEYESHLDGLQSDPQDETAAAQEAEHQLRLAALDHKRREITRLRDRRQIDDAVQRELEARLDVEEIRLLGPRTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGR6</accession>
    <name>F4FGR6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_02460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02460"/>
    <dbReference type="EnsemblBacteria" id="AEB47576">
        <property type="protein sequence ID" value="AEB47576"/>
        <property type="gene ID" value="VAB18032_02460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02460"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_5_4_11"/>
    <dbReference type="OMA" id="VNRTVVY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="62"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="21115" checksum="D900959D6E6CEEC2" modified="2011-06-28" version="1">MPGGETSQTLDRGLRLLHLVADAPGGLTVTEAANRLGIGRAAVYRLVTPLAGHGMLRRDTDGRLRLGAGVLHLARRAQPLLAEGALPALRRLAEQAGATAHLTVVEGGEGVALAVVEPSWTSFHVAYRTGARHPLERGAAGQAILAGRSGVAGPVSTVGELQPGAYGVAAPVLGVPGLEASVGVVALAPLDADAVGAQVLAAATAIAAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGZ8</accession>
    <name>F4FGZ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731285.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07450"/>
    <dbReference type="EnsemblBacteria" id="AEB42612">
        <property type="protein sequence ID" value="AEB42612"/>
        <property type="gene ID" value="VAB18032_07450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07450"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067324_1_0_11"/>
    <dbReference type="OMA" id="FAALTCE"/>
    <dbReference type="OrthoDB" id="1755732at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="292" mass="32069" checksum="62E52B61A906C5D8" modified="2011-06-28" version="1">MSVSDATNWPTSALDAAQTAFAALTCEPAPLVFDCTVLACDAGLRQPVMPLPALRDWLLRHPRAYTARDEVWRELIRRARLDGPHWVVAAVGMAMPALQRYAAALCEGYDGDPADIDAEILTGFLTALRDRADLTKPAPYASLCKAAWRAGRNLRLQRQEHVPVEDIEHVTPGSRTPRMPYGHPDLLVRRAVTLGILDPEDEQPYIDVRLGYRAIEPIAAAHGVSVDALRMRLSRIDSRIAAALADGLLTGLVSPETTARLRQRAEQRRRRRAGRAATTRRENAGQHAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH02</accession>
    <name>F4FH02_MICM1</name>
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        <submittedName>
            <fullName evidence="5">Mercuric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_07470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07470"/>
    <dbReference type="EnsemblBacteria" id="AEB42616">
        <property type="protein sequence ID" value="AEB42616"/>
        <property type="gene ID" value="VAB18032_07470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07470"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792131_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="128"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="227"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="350" mass="38087" checksum="34BCCA487B2580B1" modified="2011-06-28" version="1">MDTNRYAIVLIDMHTRRPSMSCPTPSPPGCASTPRRRDHLPGSRRQFRRERPQGAPDAIQAADRWHHLLKNLSDTVEKIVCGHRQCLRTHTDTIPALATPAAVEPVRAGRRAHPENDHSSRTTIDHYSLTLTTSTGTLELAAEQLLVATGRRPLTGGLNLDQVGVTVGRRGEIIVDEHLRTSNRRIWAAGDVTGHPQFVYVAGAHGTLIVDNAFDDADRSMDYTHLPRVTFTTPAITSVGLTDAQAAEQGLDCECRVLPLDYVPRAIVNRDTRGLIKIVAERGNGRIRGVHALADNAGDVIAAAVYAVQAGMTVAQMADTWCPYLTMAEGLKLAAQTFTRDVAKLSCCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHC9</accession>
    <name>F4FHC9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_13975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732574.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13975"/>
    <dbReference type="EnsemblBacteria" id="AEB43907">
        <property type="protein sequence ID" value="AEB43907"/>
        <property type="gene ID" value="VAB18032_13975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13975"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673748_0_0_11"/>
    <dbReference type="OMA" id="EGERYVH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="45390" checksum="448B47DA7C1EE4E6" modified="2011-06-28" version="1">MLARLAWSLLLVLLFGTMIAGRLTMSRWGISEAGDLEIRLPLLGLLLTWFLLWPWATRRELSEGWPTAMKLVVLHLGVLILAGMWADPQARVWRSIFDLLVVLTMVGIAIVATRWDPRQAALQFVVMLYATGIFFALVGLATASFSDRGRLAALGGGPNVFVRFMVLGLLAAIVLAVHRKRLWYLAPVPLLGYAALLSGSRGGLISALLIALVALLWYARRIRPRYVIGGALLALVGLRFLTNTDTDGRLGWIYRRYSIESLTENQYASRPELLRQALDIFNQHPIAGGGIDSFAATYAPGQSGAYAHNYFASVAADTGTVGLCVLAAALLAILVSAARNLSHATAPQAGLVFGALFILTASNFSGDYYDSRIGWVLLAVALTGLTSRHARDTAAAAHRARPAPSATGHRARRDLPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHH0</accession>
    <name>F4FHH0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733797.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20210"/>
    <dbReference type="EnsemblBacteria" id="AEB45142">
        <property type="protein sequence ID" value="AEB45142"/>
        <property type="gene ID" value="VAB18032_20210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20210"/>
    <dbReference type="eggNOG" id="COG2315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138549_2_0_11"/>
    <dbReference type="OMA" id="MPHPIMF"/>
    <dbReference type="OrthoDB" id="1817663at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="132" mass="14595" checksum="3A5402FE12510834" modified="2011-06-28" version="1">MPHPIMFDEADPVLGRVRTLALAFPDAAEKVSHGRPAFFTTKVFAYYGGSVKVDGVYHQHDQSVMVLVDPEERAALLTEERCFVPAYLGASGWVGVDLTDDTSWDEVGELLDASYRLTAGARRIARLDARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHL2</accession>
    <name>F4FHL2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S8/S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_26415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26415"/>
    <dbReference type="MEROPS" id="S08.051"/>
    <dbReference type="EnsemblBacteria" id="AEB46381">
        <property type="protein sequence ID" value="AEB46381"/>
        <property type="gene ID" value="VAB18032_26415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26415"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_7_11"/>
    <dbReference type="OMA" id="PKVMFVE"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309346" evidence="6">
        <location>
            <begin position="17"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="140"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="399" mass="41265" checksum="0DCEB04C4058273A" modified="2011-06-28" version="1">MATALLVSVAPSPAAAAEGNILGASNPNAIPDSYLVVLKDDTAMKTQALTRELTTTYNVKVTHTYSHTLHGFAGTMSEADARRLAAQPGVAYVEQDVEVRLTGTQTNPPSWGLDRIDQRHLPLDNTYMYPDATNRVRAYVIDSGIRTTHADFGGRAVWGINTTGDGINTDCNGHGTHVAGTLGGRAFGVAKSVSLVAVKVLGCGGVGAIAGIIAGVEWVTAQHVTRTTAVANMSLGAKGSNLTLENAIRGSILKGVLYTISSGNNNSDACEYTPAKVLEAITVNASTIGDTRALFSNWGRCTDIFAPGQEIRSAWYTSDNSSYIASGTSMAAPHVAGAAALILGNNPGLTPQQVGNVILGNATGNKIPNPESSPNRLLYVGPTGVIPVPDGAPLSPTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F157</accession>
    <name>F4F157_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, SARP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07965"/>
    <dbReference type="EnsemblBacteria" id="AEB42711">
        <property type="protein sequence ID" value="AEB42711"/>
        <property type="gene ID" value="VAB18032_07965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07965"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_2_1_11"/>
    <dbReference type="OMA" id="HQQCHDI"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="177"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="819" mass="88881" checksum="7049AA6E61159E1F" modified="2011-06-28" version="1">MSGSGREAQEALARFVGELKRLRQLAGAPSLNTLVAISASLGQPLARSTLSDKLTAKSLPDWSFVASFVNACLGHADQLGIRLPAELADLGRWDAEHLRLLRIVDAARVEDRLRAAAHMQLGQRASGTLPATRTGPAGLLDQVTPRQLPAAVPSFVGRRAALARLAALLPTGGRAATVPIVLISGMAGVGKTTLAVRYAHQVADRFPDGQLYVNLRGFDATGPAANPAEVLREFLEALGVPAQRVPVGLDARSGLFRSVLAGRRVLVLLDSAGDADQVRPLLPSSPGCLALITSRGHLPGLVTIEEAHPLILDPLSRMEAYELLAQRLGMARVENEPEAANRIIAAAAGLPLALAIVASRAAIQADFSLGRLADELTEPGVLDSFSHVDPRADIRTVFSWSYRNLDPTSARTFRLLGLHPGPDVCVPALASLASVSEAQAGRTLAVLVRANLAAEQLPGRFVLHDLLRAYAAELVSGHEPETVRREALGRLLDYYLHTAYAADLLLYDQRDPISLTPVRKGTAATPLTDRAQAWRWLAREHQVLLAAVGIAVDARFDTHAWQLAWTVNTYLDRLGAWQDQLVVQERALVAASRAGDRDGQARAHRNRAVACLRLEDYDQAHAHLDRSLALYTTLGDAIGSARAHLNLGILAERQGRYQQALYSAEQARDLFTAAGNTSGAANALNNIGWYHSQLGNFQQALDRCTQALLLQQQVGNRYWQAHTWDSLGYVHFRLDHQAEAIRCYENALVLWREAAERYYEATTLTHLGDSRHAAGAPDLARDVWQRALEILEELGHLDAEEVRTRLGSEPTQSAPTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F160</accession>
    <name>F4F160_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731387.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07980"/>
    <dbReference type="EnsemblBacteria" id="AEB42714">
        <property type="protein sequence ID" value="AEB42714"/>
        <property type="gene ID" value="VAB18032_07980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07980"/>
    <dbReference type="eggNOG" id="ENOG502Z9UG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_583861_0_0_11"/>
    <dbReference type="OrthoDB" id="445350at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="468" mass="50972" checksum="1511BF1D5D5987A0" modified="2011-06-28" version="1">MSGDQLSAAAAVVAYQAVTLTELRSLFDQVDFDLKEVLEREGRISDTLDSVTSEFDAVRARLQAMGVLVPAPPSQPVAAATVSVEASHHSRYAVPIVPTEDDFDQLVRLAEAQLDLLGIDLTRDPLQQILPPGQIAGSLRSYTEEHGDISWDEADWTVVLVAGALATILDIVLVRIPQDSTFLGTKQAGSPLTNWLKDKDRADGIHARFFKGFEKLAKVPYDAPTTKATGGLVSGMRPATHRLQSLGHDPLLGFFYGVADLMRGTGTYIDKAGQLVQVATTHDSVDLITALITQVRHLLSDVYTPAGLQPPFFSLLQLGQINSPFALTSSGVKVPWTDVARYMYTNGYDLRHFFTMGITPGIVSAIIRGYWLLKSYATGGTAAQRKLEHAKLTSMLLLGHTIATSGTLLKTGLVFGMNPAALNYSQILAMAPATIAWLKEAIARDRRINRALAQEWELLLTTSERHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1A8</accession>
    <name>F4F1A8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732611.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14160"/>
    <dbReference type="MEROPS" id="S33.971"/>
    <dbReference type="EnsemblBacteria" id="AEB43944">
        <property type="protein sequence ID" value="AEB43944"/>
        <property type="gene ID" value="VAB18032_14160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14160"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_1_11"/>
    <dbReference type="OMA" id="SAARFYW"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="408" mass="45129" checksum="D3C236E3B2E270F6" modified="2011-06-28" version="1">MAVKIEAPVRTEQIRPFTVQIPEAELDALRRRIAATRWPEKETVDDQSQGVPLATIQALARYWENEYDWRKVEARLNDLPQFLTEIDGLDIHFIHVRSRHEDALPLIVTHGWPGSVIEQLKIIGPLTDPTAYGASESDAFHLVIPSLPGHGFSGKPSVPGWGPEHVARAWTELMRRLGYTRFVAQGGDWGAIITDLMGVQAPAELLGIHTNMPGAVPPDLDALFQSDISGATNALGSLPAGLSAEERHASEQLDFVWKHVAYALMMATRPQTLTALADSPVGLAAFLLDHDARSLDLISQAFAGRQVGLTRDDVLDNITLYWLTNTAVSASRLYAENPLSFFATKGVSVPAAVSAFPDELYQAPRSWVERAYPNLVYYHRLDKGGHFAAWEQPEVFAEELRAGFRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1C6</accession>
    <name>F4F1C6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732629.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14250"/>
    <dbReference type="EnsemblBacteria" id="AEB43962">
        <property type="protein sequence ID" value="AEB43962"/>
        <property type="gene ID" value="VAB18032_14250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14250"/>
    <dbReference type="eggNOG" id="ENOG5032RS7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070264_3_0_11"/>
    <dbReference type="OMA" id="WPIGSYP"/>
    <dbReference type="OrthoDB" id="1658396at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="19854" checksum="305F483EFF46103E" modified="2011-06-28" version="1">MTTQSNPPAWQPGVTGGGTLPSGPGGRTAAPSGDGHGPQLGPPTVTIGAYPDYPSAQRVVDHLADNRFPVERSAIVGTDLTLVETVLGRMTTARAGLIGAGTGAWFGLFIGLLFGIFTVGNWLAVILAGLVIGAIWGAVFGAVAHAMTGGKRDFTSASSLRANQYAVIVDADVAEQARQLLGRLHLGGRAPQTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1D1</accession>
    <name>F4F1D1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14275"/>
    <dbReference type="EnsemblBacteria" id="AEB43967">
        <property type="protein sequence ID" value="AEB43967"/>
        <property type="gene ID" value="VAB18032_14275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14275"/>
    <dbReference type="eggNOG" id="ENOG5033NR2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130918_0_0_11"/>
    <dbReference type="OMA" id="MNGLFSN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045647">
        <property type="entry name" value="DUF6401"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19939">
        <property type="entry name" value="DUF6401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="103" mass="10547" checksum="48504364567BA93D" modified="2011-06-28" version="1">MGLANAVGLDGLAAANQLPGLLAVVDQHAAAVRDSLHGDQRPLTAAALAGYAEGVRAAADEHGWQPPTDPIDWSEADWVLVRLLAVCALTAALDTPAPQPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1D9</accession>
    <name>F4F1D9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732642.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14315"/>
    <dbReference type="EnsemblBacteria" id="AEB43975">
        <property type="protein sequence ID" value="AEB43975"/>
        <property type="gene ID" value="VAB18032_14315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14315"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019327_1_0_11"/>
    <dbReference type="OMA" id="WSYTHLP"/>
    <dbReference type="OrthoDB" id="453021at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="537" mass="56809" checksum="97536EF80FF3A182" modified="2011-06-28" version="1">MISPGSTGSERADAVVIGAGHNGLVAANLLADAGWDVLVLEATQVPGGAVRSAQVTAPGYLSDLYSSFYPLGYVSPVLRDLDLPRHGLVWRHAPDVLAHLFPDGRAALLNRDPAVTAASLEEFAPGDGQRWLTAYEQWRQVAAPMIDVITTPFPPVRGGLDLLRRLRVGGALRLARRMVLPVRRLGAELFAGDGGTALLAGCALHTDLSPEEAGSGVYGWLLAMLGQQVGWPVPVGGAQKITDALVDRLTERGGRISYGARADRVLIARGRAVGVRTVGGRLWQARRAVLADVPAPALYLDLVGASALPPRLVADLEHFRWDGSTLKVDWALSGPMPWRNPRLSTAGTVHLGADLGGLTGYAADLARGDLPRDPFLLLGQMSVADPSHSPPGTESLWSYTHLPFRQDWRAEELMTHVERMEEVLEAAAPGFRQLVVGRHVAGPAELEQANPSLVGGALGGGTAAPYQQLFLRPIPGLGRADTPVDRLFLASSSAHPGGGVHGAPGANAARAALARDGVLTGDLYHGAVRTAHRAIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1K8</accession>
    <name>F4F1K8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733891.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20685"/>
    <dbReference type="EnsemblBacteria" id="AEB45237">
        <property type="protein sequence ID" value="AEB45237"/>
        <property type="gene ID" value="VAB18032_20685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20685"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_1_3_11"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="171" mass="17780" checksum="967272247CDB44E8" modified="2011-06-28" version="1">MTHTGPDRLVETARFRAAFRQVPAPVAIILVPGGPAGVTGLTCTSATSLSGEPPMAMVGIDQKTGLAALAQQAGRFSINYLAADRATWAQAFAARGRHLDELAAAVIAGHTTVPTLATGTTAVLECRTTTVHPGGDHFILCGEVLHTRAQTDAPPLLYLGGRYGSFQPTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1L5</accession>
    <name>F4F1L5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20720"/>
    <dbReference type="EnsemblBacteria" id="AEB45244">
        <property type="protein sequence ID" value="AEB45244"/>
        <property type="gene ID" value="VAB18032_20720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20720"/>
    <dbReference type="eggNOG" id="ENOG50340G7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_595339_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="467" mass="49558" checksum="1080295083AB2921" modified="2011-06-28" version="1">MTRNMETELREALRTEADTLAVTADPWPRFTRREAGHRRARRVRTGAIAAFLTAAVAIQTNLIPLPGWVPGIAVASSPSPLTDGPARGDLAADHNWTDGLLRQVADLQEPGGWWRVTDRDDIRIVYADDIPGRRIALLLVPLRLGLLTDATLVWFSGPPGAEPEQMRKGGNEPADTPVAIWMESDPTNGGAAVVIGPAGSTVTINGFSGYSSTGVVESHQLSSSVGTGIGVTSLPPTDMVGGPALTARVTNGDTLIYEGPVYGLWSGSDTDRQEPTDEMLTAAVRDTRGSVIDRDVLARFIDHALRDSRLSAQDVTIRVRWCGTVNDKPATLFTIQPTDGGVIAYAVHGDITSWRTDLRLLLPADGAERRPIAWRMRAEGGDTRTDRVMLVAPPQAVTAAITARDGTRTPVVLDPSGFGSTTIPPNMPATVTASTADGTPFISTPVPGFDANAGGLPGTSRNTRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1S1</accession>
    <name>F4F1S1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735147.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27116"/>
    <dbReference type="EnsemblBacteria" id="AEB46496">
        <property type="protein sequence ID" value="AEB46496"/>
        <property type="gene ID" value="VAB18032_27116"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27116"/>
    <dbReference type="eggNOG" id="COG2867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128243_0_0_11"/>
    <dbReference type="OMA" id="MLGMIKR"/>
    <dbReference type="OrthoDB" id="1691158at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="16931" checksum="3C7589D69D377B6C" modified="2011-06-28" version="1">MADSSTQSITIAASPDQVATVICDFPSYPRWTDAMREVEVIEEYEDGYASQVRFVLDAGVLADEYVLEYAYAEDLSRIEWHLVTPSKMQRLQRGSYDLVGNADGSTTVTYTLEVELAVGMLGMFRRKAEKMIMDTALKQLKRRVEATGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F263</accession>
    <name>F4F263_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731424.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08170"/>
    <dbReference type="EnsemblBacteria" id="AEB42752">
        <property type="protein sequence ID" value="AEB42752"/>
        <property type="gene ID" value="VAB18032_08170"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08170"/>
    <dbReference type="eggNOG" id="COG1832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_0_0_11"/>
    <dbReference type="OMA" id="MVMDRCP"/>
    <dbReference type="OrthoDB" id="1910664at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="135" mass="14602" checksum="63D1D7C59CEA64EE" modified="2011-06-28" version="1">MRSPSQILAESAVIAVVGASRDPDKTAHSVPAAMQRQGWRIIPVNPFADELFGEPAYRTLADIPHPVDLVNVFRPAEDAVEVVRQAVAINAPAVWLQLDIVSPQARQIAEQAGIDYVENRCIAVERAVAGLTRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2B7</accession>
    <name>F4F2B7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42806">
        <property type="protein sequence ID" value="AEB42806"/>
        <property type="gene ID" value="VAB18032_08440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08440"/>
    <dbReference type="eggNOG" id="ENOG5034BVZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1011264_0_0_11"/>
    <dbReference type="OMA" id="VHWDGTP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="32506" checksum="141923095D32E8F4" modified="2011-06-28" version="1">MNRVTGSRAARDHDDGLPTDARPDPGTAPRTPWSEVAAAARTSAVAPQPRTVPPDGATSTDPAPPGVEVEPTTGAPVDALPRRVPLRAAGRRGRRTDDGTEEVFWAPIEQVHWDGTPVRQDASGATRAWWRPTWRLRRDRKRSSRPPDPLAGLAALVGLSLATAFFAWVSAGPLWLAVGHATSGSVVVTDCTGGGLSQRCRGNFAAAEDRFRSYGIRVSGVPERRATAGAVLPARVTGPNADIAYADRGIGAHLRWLLGLLGVLGCAAGIARWTGATRFSDPGDRRWAVAAAFAGPLVITLGFLVAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2J9</accession>
    <name>F4F2J9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733918.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20820"/>
    <dbReference type="EnsemblBacteria" id="AEB45264">
        <property type="protein sequence ID" value="AEB45264"/>
        <property type="gene ID" value="VAB18032_20820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20820"/>
    <dbReference type="eggNOG" id="COG3879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040273_0_0_11"/>
    <dbReference type="OMA" id="VHEQHVF"/>
    <dbReference type="OrthoDB" id="1711743at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="31896" checksum="42198B5374AF379D" modified="2011-06-28" version="1">MTDEHTETGTGWPQPAGPVRPDGPAGEPDPRPEAPDPDELSPLSPQGRPPEDDAPANGGDESAAGSFAAAVAAGWRRFGSATVMISVLLVLLGFTLAVQLKTTSTDSSLAAARQEDLVRILYDLEARDVRLRQDISALEESQRQLRSGEQGRQAALQEATRRADELGILAGTLPARGPGLAVRFQAGAKPISAIRVLDAVQELRGAGAEAMQISGGDRASVRIVASTYFLDGENGSLIVDGRPLSGPFTITVIGDPATMRTGLNIPGGVVASVAQDGGNVIVEDREVAEVSALHVPRTLEHARPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2R7</accession>
    <name>F4F2R7_MICM1</name>
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        <submittedName>
            <fullName evidence="7">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_21160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733986.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21160"/>
    <dbReference type="EnsemblBacteria" id="AEB45332">
        <property type="protein sequence ID" value="AEB45332"/>
        <property type="gene ID" value="VAB18032_21160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21160"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="AHENLMF"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="318" mass="33664" checksum="C03ECC13C8EA66DB" modified="2011-06-28" version="1">MGASFAAELHEVSKRYPGGVTAVDGLSLRVREGEVLGFLGPNGAGKTTTMRMLVGLVRPSAGRIQVLGQPPGRQLARIGALIESPTFYPHLSGRDNLRLAARYAGVPDAAADRVLDEVGLTARASSPFRTYSLGMKQRLGVAAALLKEPALLILDEPTNGLDPAGVAEMRELLRSLGQGGRTVLLSSHVLGEVEQVCDRIAVIDRGRLIAEGTPDELRDALGTGVLLIDADPADEAIACLGADDRVRAVEQVDGTLRVSTDPALAGALNRRLVTAGVDVRELRPLRHSLEEAFLELTTPTASAHRRSDQPEATTGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3I0</accession>
    <name>F4F3I0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GH26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_14880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732755.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14880"/>
    <dbReference type="EnsemblBacteria" id="AEB44088">
        <property type="protein sequence ID" value="AEB44088"/>
        <property type="gene ID" value="VAB18032_14880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14880"/>
    <dbReference type="eggNOG" id="COG4124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038234_2_0_11"/>
    <dbReference type="OrthoDB" id="669354at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="7">
        <location>
            <begin position="258"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="571" mass="61969" checksum="BBE2BADA6547C2BE" modified="2011-06-28" version="1">MTRRGLHRLIRHPGPRRKAVVLGALGITVVLGLTATMVPLLADDDVSIPVVADTTATAVVQDGDNSVKSTLATCPARCDGNPRGGRDAVLAFMVTTLPANATNVRATLRVHAWQAFKATVSAHASNLDATAQRPAPERLASALDTVTGVAKGFNEWDVSGLVTGNGIWTVSLAQAGLDTRIYWASAENRSADLRPNLVLSYDVAGRPAPPPPSATLPPTAEPTRPPVSPSPSPSASPSLSPTPARPTPTATRPPADSGACGKVSDKLVPSCGAWWGMYSPTNPQTWDHGRAVTDIEAQVGRKFDIVHRYHDFSNTGSNGAFPDAYQQQQMREGRLMFFAWESRVFSSGTVLTWKDVYSGRYDETIDAVAGRIRAVGQPVFIGFDHEPEDEPAKGSDADFVRAWRYVHDRFAAADVRNAVWVWTMMGWSGHYDRYAGLYPGDRYVDWVAWDPYNFHVCNGSTVWKSPSTTVGSFYRWLDEKGIGAGKPRMLAEFGTNFDANDPNAKRRWFEEFPAALKAHPKIKAAIYFNSPGMTTTTKTCNMTMNHDAAALAGFTAAGRDSYLRQPTGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3J7</accession>
    <name>F4F3J7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ordered locus">VAB18032_14965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732772.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14965"/>
    <dbReference type="EnsemblBacteria" id="AEB44105">
        <property type="protein sequence ID" value="AEB44105"/>
        <property type="gene ID" value="VAB18032_14965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14965"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_11"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB44105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="19934" checksum="6B1826688C8697CD" modified="2011-06-28" version="1">MATTNDLKNGLVLNLDGELWAVVEFQHVKPGKGGAFVRTTLKNVLSGKVVDKTFNAGTKVETATVDKRTMQYLYADGEDYVFMDMETFDQITVPGGTVGEAANYLLPEAEATVATHEGVPLYVELPTSVVLEITYTEPGLQGDRSTGGNKPATVETGATVQVPLFITTGEKIKVDTRDGRYLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3T1</accession>
    <name>F4F3T1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-amino-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734035.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="SMR" id="F4F3T1"/>
    <dbReference type="STRING" id="263358.VAB18032_21410"/>
    <dbReference type="EnsemblBacteria" id="AEB45382">
        <property type="protein sequence ID" value="AEB45382"/>
        <property type="gene ID" value="VAB18032_21410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21410"/>
    <dbReference type="eggNOG" id="COG1231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_8_3_11"/>
    <dbReference type="OMA" id="YFAGDHL"/>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307649" evidence="1">
        <location>
            <begin position="39"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="538" mass="58385" checksum="ABD889B681119AD1" modified="2011-06-28" version="1">MTSPTTRRQFLQAVGVSGGAGVLYSTMVALGLAPAAQAAPAFRAPNRSDFTLTGRSAKSVLILGAGVAGLATAYELAKAGYRVQILEARNRPGGRNWTVRGGTVETDLDGQTQRARFSGGQYLNAGPARIAQHMVTLDYCRELGVPVEVFGNQNADSYYFNDNVGALSGQPIRHREAKADVYGYVSELLAKATDQGALDTHLTGEDKERLLEFLRSFGAIGPRVAGDPAASWRYTGTNRRGYEVEPGAGFQAGTPKLTPYPLSDVLASGVGRYFSFEFGYDQAMLMFQPVGGMDRIAYALEEAVGRRHITYDAEVRSISNTGAGVSVVYTGPGGRTRTATADFCVCTIPPQVLAKIPSNLTEPVRTALAYAVPNATGKIGLQYRRRWWEQDEKIYSGITNTNLDLSAIWYPSYGYHGAKGVVVGYYNNGANARAYAALSPADREARAVAQGVRIHGEKYRTELETSFSVAWERTRYSEGGWVSWPSRTTGGHYGRLLEPDGRVYFAGDHLSHYIAWQAGAFESARKVVTDLHTRVMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F461</accession>
    <name>F4F461_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">VAB18032_03960</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736506.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03960"/>
    <dbReference type="EnsemblBacteria" id="AEB47874">
        <property type="protein sequence ID" value="AEB47874"/>
        <property type="gene ID" value="VAB18032_03960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03960"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_1_2_11"/>
    <dbReference type="OMA" id="LQYCPTC"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB47874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="286" mass="30592" checksum="85ABF66088497521" modified="2011-06-28" version="1">MPELPEVEALAGYLRQRAVGRRVERLEAVAISALKTYDPALTAVTGRSVTDARRHGKFLDVVFDGDLHLVVHLARAGWLHYREAFASTVPLRPGKGPIALRARLDDGSGFDLTEAGTQKKLAVYLVTDPQAVPGVAKLGPDALSADLAAFAGALRSRRGQLKGVLTDQAVLAGVGNAYSDEILHAAKLSPFALTDRLTDDQMATLHAATRRVLGDAVTRSLGQRAAELKGEKRSGLKVHARTGLPCPVCGDTVREVSFADSSLQYCPTCQTGGKPLADRRLSRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4C8</accession>
    <name>F4F4C8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47941">
        <property type="protein sequence ID" value="AEB47941"/>
        <property type="gene ID" value="VAB18032_04295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04295"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061547_0_0_11"/>
    <dbReference type="OMA" id="WERGAAN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="318" mass="34178" checksum="00A815FCF6C194A2" modified="2011-06-28" version="1">MDPWDASGLHAWQEPAEIRDRGAAGPADPWDADSTSQWLRTSASDQWLEPDQTGQWLQPDTTGQWERPAEVDRWDRRRGEDRWDGYSGPDRWDRTQPPGSGATSGAGQWAWAEPAAPEPAPERFWPGTRLAGDDPRWVEASASAPRSPVVGYTAPRPRSATRRRPAAVPAPRQTGMESVRRRIEAVGTGGWSRRLEDDLLDPDPGAPWLPLLYTAACYLLPAVVIFFWLLTLDGAPPTGCVTDISGGGCESPRARAFGATVGGIPRFGLALVSSLVVATLLRRVGTSWKPTTVALAAAVVGGGLSTVMISAVTGEPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4E0</accession>
    <name>F4F4E0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731569.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08900"/>
    <dbReference type="EnsemblBacteria" id="AEB42898">
        <property type="protein sequence ID" value="AEB42898"/>
        <property type="gene ID" value="VAB18032_08900"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08900"/>
    <dbReference type="eggNOG" id="ENOG5031VF6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175330_4_1_11"/>
    <dbReference type="OMA" id="APVSQWA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7020" checksum="F668A54E1FF0D252" modified="2011-06-28" version="1">MCGEEPLLRIVRGVPTAEELAALVGAVVTRPRAAGPAPAPTSTWARSGRPGSNGHLPGPGAWRASALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4N6</accession>
    <name>F4F4N6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732843.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15330"/>
    <dbReference type="EnsemblBacteria" id="AEB44178">
        <property type="protein sequence ID" value="AEB44178"/>
        <property type="gene ID" value="VAB18032_15330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15330"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_13_3_11"/>
    <dbReference type="OMA" id="QHGGVYC"/>
    <dbReference type="OrthoDB" id="2060970at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="14272" checksum="86C52EA1EC2A7B0A" modified="2011-06-28" version="1">MEMSELSTGFFALLGLEYGEASGDRVTVRWRVRPELLQPYGIQHGGVYCSVVETAASVGAGLWLGERGRVVGVSNQTDFLRPVGDGELTAIATPVHRGRSQQLWQVEITDAKDRLVARGQVRLQNLYPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Z5</accession>
    <name>F4F4Z5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734137.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45484">
        <property type="protein sequence ID" value="AEB45484"/>
        <property type="gene ID" value="VAB18032_21920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21920"/>
    <dbReference type="eggNOG" id="ENOG5033U8B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1250215_0_0_11"/>
    <dbReference type="OMA" id="TTGTNGM"/>
    <dbReference type="OrthoDB" id="2158623at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="221" mass="22378" checksum="46236997144CF360" modified="2011-06-28" version="1">MTLADNDPGARLAGMLLLISLVAILTAAAIVVPSGLTLNPADPATTLTAVHDHVGLHLTELAFDVLGWLALTAAGLVLAGKPDVMVRPHLAVLAGGLLAAAGLAGLLHDAGNLAVTQLAATPADTVADVAGAVLLTAKWTVNLAGLLWAAAAAVTAIGVDLPDRLRRAGGLAALAGLAAVAVPWTTGTNGMSPTLEQLGYALQLPVMIWYGLLGWRLVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F570</accession>
    <name>F4F570_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ordered locus">VAB18032_28406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735402.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28406"/>
    <dbReference type="EnsemblBacteria" id="AEB46752">
        <property type="protein sequence ID" value="AEB46752"/>
        <property type="gene ID" value="VAB18032_28406"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28406"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_11"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="625" mass="68507" checksum="A9369158FA738F3C" modified="2011-06-28" version="1">MPPTLDTGANAPGATDPARIRNFCIIAHIDHGKSTLADRMLQLTGVVDPRQMRAQYLDRMDIERERGITIKSQAVRMPWTIRDGERAGEQAVLNMIDTPGHVDFTYEVSRSLAACEGAILLVDAAQGIEAQTLANLYLALENDLHIIPVLNKIDLPAAQPEKYAEELAHLIGGDPADCIKVSGKTGEGVPYLLDEIVRQFVPPVGDADAPARAMIFDSVYDVYRGVVTYVRVIDGRISARDRIKMMSTGAVHELLEIGVISPEMVKSDALGVGEVGYLITGVKDVRQSRVGDTVTINGRPAAEPLGGYKDPKPMVYSGLYPIDGSDYPALRDALDKLKLNDAALTYEPETSGALGFGFRCGFLGLLHLEIIGERLEREFNLDLISTAPNVVYRAISEDGQEVVVTNPSEYPTGKIAEVYEPTVRASVLTPNDYVGAVMELCQSRRGSLLGMEYLSADRVELRYTLPLAEIIFDFFDQLKSRTKGYASLDYEPTDEQASDLVKVDILLHGEPVDAFSAIVHKDKAYAYGTTIAAKLRNLIPRQQFEVPIQAAIGSRVIARETIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGRVEVPQEAFIAALSSDSGDGKPTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5A6</accession>
    <name>F4F5A6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_04360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736585.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04360"/>
    <dbReference type="EnsemblBacteria" id="AEB47954">
        <property type="protein sequence ID" value="AEB47954"/>
        <property type="gene ID" value="VAB18032_04360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04360"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_11"/>
    <dbReference type="OMA" id="INNPKSC"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="159" mass="16985" checksum="911DD8831900EE40" modified="2011-06-28" version="1">MRWTLLDSPIGIFSVATEGGSVCGTRFGPVETATEVPADETSRRAVAELRAYFAGELTEFDIPVTVPRGSDFERAVWREMTRIPYGETLTYGQVARLVGDPGAARAVGVACNRNPIPVIVPCHRIIGAGGKLVGFGGGLDRKVKLLELEAGVALQQAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5L1</accession>
    <name>F4F5L1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09625"/>
    <dbReference type="EnsemblBacteria" id="AEB43043">
        <property type="protein sequence ID" value="AEB43043"/>
        <property type="gene ID" value="VAB18032_09625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09625"/>
    <dbReference type="eggNOG" id="ENOG5033U9G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670514_0_0_11"/>
    <dbReference type="OMA" id="DQAGEWF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025850">
        <property type="entry name" value="SUKH-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025968">
        <property type="entry name" value="YwqJ_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14433">
        <property type="entry name" value="SUKH-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14431">
        <property type="entry name" value="YwqJ-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="410" mass="45038" checksum="8DD8173042088DDA" modified="2011-06-28" version="1">MIDREQAEQIAAVWARRDSQRLGHECRPMVTEFDLGYVITSTVSTQVRSMPGDLPTTVVDKETGEVTTWPRVPPDVVEQLFRRGRPTGPPAPRTVDPAGQLLREIRRLPTPTTAAHLTIEGRIFTAHGAKGDIELNHHPLVRAYLDGLPAGHLVRGGDRHAELVVVSDVLHEYDHRRTAEGIAPMEAGDAEALLSAARFDCYLVREEGDPAGGRVERPCDTCINFLVHFNVLPWSERGWTAPWYPEPAPDPEPGRFPADVTNALVAAGWRPHFGDEVVATSAIRDVREVRGKTHEHAVPPAALRTLTAFPSLVGAKLGPGEEVWISRFDIRPRQVAHTADTLADFAAVIGARLFPIGTENQHSIIAVDEHGRIFALDQAGEWFLGANIDEALVTLLLGRAPARVRDDGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5L7</accession>
    <name>F4F5L7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44230">
        <property type="protein sequence ID" value="AEB44230"/>
        <property type="gene ID" value="VAB18032_15590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15590"/>
    <dbReference type="eggNOG" id="COG5502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2588767_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="80" mass="9018" checksum="6E0B257F5E94D3F1" modified="2011-06-28" version="1">MARPTEDPERFGLAEFFERVQSRAGVDHQVATDGARAVLDTLRESVRAKEYGDTVDQLPQEFWQLTGPRAERLQTRGVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5M2</accession>
    <name>F4F5M2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15615"/>
    <dbReference type="EnsemblBacteria" id="AEB44235">
        <property type="protein sequence ID" value="AEB44235"/>
        <property type="gene ID" value="VAB18032_15615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15615"/>
    <dbReference type="HOGENOM" id="CLU_2792877_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="68" mass="6870" checksum="5938C7EE5BC36928" modified="2011-06-28" version="1">MFSGSSIKSDGDDAHHHAVCGACGDMRQLPEAVDASLATARAVGPDLPAQPGGVVVYGRCAGCRTATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5P7</accession>
    <name>F4F5P7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732924.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15750"/>
    <dbReference type="EnsemblBacteria" id="AEB44260">
        <property type="protein sequence ID" value="AEB44260"/>
        <property type="gene ID" value="VAB18032_15750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15750"/>
    <dbReference type="eggNOG" id="ENOG502Z9PB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031612_0_0_11"/>
    <dbReference type="OMA" id="FHPKLWA"/>
    <dbReference type="OrthoDB" id="668062at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="583" mass="62067" checksum="0B3D68D0B3E530E1" modified="2011-06-28" version="1">MLAPDSRALLLDALRPPAGARLSRAVALTFTLDLESLLVAPLAFAAQGLRESTDPITVMEGVRHCADRIDVFCQAGQITVPPTQSALLAFVEPMVHQVRRPKPGHLFHPKLWALRFHDETTGETSLRLLVLSRNLTKDRSWDVCLRLDGVIGPRPKADNRPLSDLLRHAMRLAVAPPPPVRQAAIEALAEDLRRAQWELPDRAREMSFHALGVPGACPPRFEGTRHLIISPFCTPGGLGRCAPGGQLALVSRQETLDCLPEETVVGSEAFVVNALAGLPAEGAPPGQEVLHGLHAKVYVVEKGHQARVLLGSANATDAAFGGNVELLVELVGSRAQWGINAVLGPEAGLRGILDPYDRHDATESEPESTALRDLIRDIAAIPLSATVTTDTDSYGIRLTSQEDLPDLPGVRLTAQVHTRRGEAVPLVAGQPAAAVFAGLALADLTPFIVITAEDTTGREQTVVLATLIGDPAHRLDHVLAQQIDTPEKFLRFLLLILGLGTEAAAAVGGGTGGSGAWRAGGAGILELLLNALADRPDQLDDLARLVTRIEASGDSGRLLPAGFPALWRVITAARETMTEAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5V8</accession>
    <name>F4F5V8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22085"/>
    <dbReference type="EnsemblBacteria" id="AEB45517">
        <property type="protein sequence ID" value="AEB45517"/>
        <property type="gene ID" value="VAB18032_22085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22085"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_2_0_11"/>
    <dbReference type="OMA" id="PGCLTIV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="844"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="941" mass="102728" checksum="8F3552F53DEC3033" modified="2011-06-28" version="1">MPIHFDLLGPLSLVRDGRPVDLGSVKQRLVLACLLFRPNEAVSKERLVTALWDDQPPASANANIRTYVRGLRQALHDEADDQPRIVTTHGGYLLRVEPDERDLDRFDAATARGREALTSGDAERAEAELVAALGLWRGRALAELPLPPQLSRWVEQLMERRLLAEEDHAEAKLALGAPAEVIPRLRALLDRHPLRQRAWVHLMSALYASGDVAGALAAFRQVRRVLAEETGMDPGPELTRLHDDILHHRRHPDGSSATVERVAVSSVRVRPEQLPLVPPGFVGRELHLSRLDAAVGDRASGPTTVVISAVCGMAGIGKTALALHWAHRVADRFPDGQLHVNLRGYDDGERVAPADALLGFLEALGVPLARIPSSLDARIGLYRSLLASREMLIVLDNARDAEQVRPLLPGAGRCVVVVTSRDQLHSLVAAEGARLLALDLLTATESRNLLRSRIGGDRLDDEPDAVADMIEASGRLPLALSIVAARVATRPTFPLEAIAAELRPPEARLEVLADGDVRRVFSWSYRALSPVAARLFRLIGLHPGPELTSAAAAALLGCSAAAVGPVLKELTRLHLLTEHRPDRYACHDLLRSYAAELTQGAEQGAERHDARHRLYDHYLHSAYPAARLVQPQWTPITPVPALGDVIHVPMADQDAALAWFSTERRVLLRVIRQAATTGFEAYAWQLAWALTTFLAPRGLWHDQFAAQQVALQAAECLGDLNAQATASRLLGRAAARLGQHDTAGDRLEWAIKLYEQLDDEDGLAQTLHNYTEHCFVLGRVDEALTHGHEALRLYRRTGNRAGEGRALNAVGYMHAVRGDYRQAIVDCTAALTQQRLIDDHNGQAATLDSLGFAYHALGDHARAVSCYERSVELFRASADRYHQAETLVRLGETHAAMGNAEAAAQAWRLASAIYDDLGDPTVDDARRRLAGLGQAVGGPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6C2</accession>
    <name>F4F6C2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731739.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09750"/>
    <dbReference type="EnsemblBacteria" id="AEB43068">
        <property type="protein sequence ID" value="AEB43068"/>
        <property type="gene ID" value="VAB18032_09750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09750"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762138_0_0_11"/>
    <dbReference type="OMA" id="ARWWITE"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="200"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="369" mass="39714" checksum="CAE0978548B8EB54" modified="2011-06-28" version="1">MTPETIEAHGVRLRPFRPADEADVVAGCADPLTQRFLDGLPSPYTEADARWWITEGAPAAFAAGGAAYAVADPATDRLLGTIGLSHAMPPRRQAEIGYWVHPDARGRGVATAATRALAERAFTDGIERLELLAQVENVASQRVALATGFRPEGIRRGGGRARDGGRRDLAVWVRLADDPPGPYPRLLPDLPGGRLTDGVIVLRRLGPEDTDEMYRLNTSPDVVASRVPPGPPAREEIVRRSVGAAHQWLVGTVASMTILDAASGSVAGTCMLLHDQPGGQGMLGYSLFPQWRGRGFATRAVRLLARWGFEQVGLARLWAGTLPENQASRRVLERAGFRYEGLLRARLPGAEGSRGDSTVYGLLPGELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6G2</accession>
    <name>F4F6G2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731779.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09950"/>
    <dbReference type="EnsemblBacteria" id="AEB43108">
        <property type="protein sequence ID" value="AEB43108"/>
        <property type="gene ID" value="VAB18032_09950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09950"/>
    <dbReference type="eggNOG" id="COG3795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130902_0_1_11"/>
    <dbReference type="OMA" id="KEVVGGW"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="126" mass="13892" checksum="C53C454E9A479D31" modified="2011-06-28" version="1">MRFMVMHKLDENRPELWQPDEAFMARMGAFMGEANQAGVLLAGEGLRPSSVDAGRITVTGGKATVTDGPFAETKELIAGFALLQVRDKAEAMHWAQKFTDIFIAADIDVEVDVRRVTEWEDLAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6R0</accession>
    <name>F4F6R0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglycosylase-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734237.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22425"/>
    <dbReference type="EnsemblBacteria" id="AEB45585">
        <property type="protein sequence ID" value="AEB45585"/>
        <property type="gene ID" value="VAB18032_22425"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22425"/>
    <dbReference type="eggNOG" id="COG2261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160040_1_2_11"/>
    <dbReference type="OMA" id="DWIRHIF"/>
    <dbReference type="OrthoDB" id="2084822at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="88" mass="9314" checksum="BAD9EE7B7E26DD92" modified="2011-06-28" version="1">MEITGFFTAIIIGLIIGALGRLVVPGRQRIPILLTLAIGVVAALLGTLVAGVLGVDDTRGIDWIELFIQIAFAAVGVSLLARTYGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6T4</accession>
    <name>F4F6T4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">ureC</name>
        <name evidence="13" type="ordered locus">VAB18032_22545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734261.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22545"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="EnsemblBacteria" id="AEB45609">
        <property type="protein sequence ID" value="AEB45609"/>
        <property type="gene ID" value="VAB18032_22545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22545"/>
    <dbReference type="eggNOG" id="COG0804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_11"/>
    <dbReference type="OMA" id="GFDSHIH"/>
    <dbReference type="OrthoDB" id="157757at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="132"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB45609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="567" mass="59803" checksum="8134E4C49F3C0A4D" modified="2011-06-28" version="1">MSIVERNRYAALYGPTTGDRIRLADTNLLIQVEHDHCVGGDEAVFGGGKVIRESMGQSRATRAEGALDTVITGAVVLDHWGVVKADVGLRDGRIVALGRAGNPDTMDGVHPDLVIGPATEVIAGNGRILTAGAVDTHVHFICPQIVTEALAGGVTTLVGGGTGPAEGTRATTVTPNAWHLARMHEALDTFPVNVLLLGKGNTVSTEALWEQLRAGAGGFKLHEDWGTTPAAIDACLRVADASGVQVSIHTDTLNEAGFVADTLRAIGGRAIHSYHTEGAGGGHAPDIITVAGEPNVLPSSTNPTRPYTRNTLAEHLDMLMVCHHLNPAVPEDLAFAESRIRPSTMAAEDLLHDLGAISIIGSDSQAMGRVGEVVLRTWQSAHVMKARVGALPGDGAADNHRARRYVAKYTICAAMANGLDHEIGSVEPGKLADLVLWEPAFFGVRPHLVIKGGMIAYAQMGDANASIPTPQPMLPRPMFGAHGGAAAVTSLAFVAPAALEAGLRLDVRRRVVPVADVRSRGKADLPENNALPRIEVDPDTFTVRIDGEVVEPDPVTELPMAQRYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Y0</accession>
    <name>F4F6Y0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734307.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22775"/>
    <dbReference type="EnsemblBacteria" id="AEB45655">
        <property type="protein sequence ID" value="AEB45655"/>
        <property type="gene ID" value="VAB18032_22775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22775"/>
    <dbReference type="eggNOG" id="ENOG5031TC2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2920007_0_0_11"/>
    <dbReference type="OMA" id="EYTVPTW"/>
    <dbReference type="OrthoDB" id="2097674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="61" mass="6912" checksum="B21AA9470522A0CF" modified="2011-06-28" version="1">MFPSEPPTPGAQRQGWLERRRDKVRAEIERNRRGEYTVPTWVLAAALALIVGAWLALIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F742</accession>
    <name>F4F742_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_29176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="ELTACWR"/>
    <dbReference type="OrthoDB" id="1986546at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="104" mass="11228" checksum="578B7740F9EF91CF" modified="2011-06-28" version="1">MAYAERGISAPPEVVFNTATDPDRSSAWLPEPLLSAVPDGDPDGLWARWRARDTDWTAELRVAAEDSGGTRARLDLVGDGRPDRLADQALTNLAREVADNLQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F792</accession>
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            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ordered locus">VAB18032_10160</name>
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    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
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    <dbReference type="STRING" id="263358.VAB18032_10160"/>
    <dbReference type="EnsemblBacteria" id="AEB43150">
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        <property type="gene ID" value="VAB18032_10160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10160"/>
    <dbReference type="eggNOG" id="COG0602">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089926_1_0_11"/>
    <dbReference type="OMA" id="EVNGPGC"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="37"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="216" mass="22827" checksum="59FA89EEC20A8062" modified="2011-06-28" version="1">MSEPVPIPRGPAETVALARFLAATRAEGPGERTAIWVQGCAIRCPGCFNPHLWGFRGGEQVAPHELARLVLDAGTDGLTLLGGEPFDQAAALARVAAEVGAAGRSVMTFTGYTRSQLDAAVDAGRTDVAALLAATDLLVAGPFQADRIDIRRPWVGSTNQEFVVLSDRFPDLLDELPANPDRVEITVDPAGRVAVNGWADPDALDELLAGLRASHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7C7</accession>
    <name>F4F7C7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_10335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10335"/>
    <dbReference type="EnsemblBacteria" id="AEB43185">
        <property type="protein sequence ID" value="AEB43185"/>
        <property type="gene ID" value="VAB18032_10335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10335"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033532_1_1_11"/>
    <dbReference type="OMA" id="TLTFYVV"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="411" mass="41990" checksum="42C2020EA0160714" modified="2011-06-28" version="1">MKPYREALALPGLRSLLLVAILARVPLTATGITLTFYVVQDLGRGYGAAGLVGAAITVGAAIGAPLLGRLVDRRGLRPVLVLTVVAEAIFWSTAPMLSYALLLPAAFLAGLLALPIFSVIRQSIAALVPVAKRRPAYALDSMSVELSFMIGPALATVGVTTISARLTLYLVGAGIVVSGAVLWLLNPPVRSASETTSGPQPRLARRQWLTSRMIAVFAVSAAATLVLGGTDVAVIAALRENDDTAFTGVVLAVWAIASLVGGFAYGAARRSFSPVALIGLLGLLTIPVGLGGSHWWLLALALIPAGVLCAPTLASTSDAVSRLAPASVRGEAMGLHGSAVTLGMAVGAPLSGAVIDASSPLWGFAVIGAIGTLVTLAVLPVELRHRRDDAAALTTATTDKNTPQPLTPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7E6</accession>
    <name>F4F7E6_MICM1</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731875.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10430"/>
    <dbReference type="EnsemblBacteria" id="AEB43204">
        <property type="protein sequence ID" value="AEB43204"/>
        <property type="gene ID" value="VAB18032_10430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10430"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415009_0_0_11"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="661" mass="67971" checksum="DF133CC615780D00" modified="2011-06-28" version="1">MQPDGPYRYTHLLGGSPVGKAWAALDQQGRFVTVAVLDATVAAAPGWREAFAGIVNHLAQTPGGTPFVYADFSAAAPWVAYGPEAGPAAEKLFQALGVAYQPVPPSAPPAVSPPVSGVPHPVSGVPQTVPGVPQPASGVPQSVSGPPQPVSGVPQPVSGAAQPASGPPQYPSGPPQAVSGPPQPVFAAPQPAGPVSAQPVYSDPVSGAPASPGFGPTVDDPLRHDPFSSPARRIQPSTSRKRQGGLWIAIAALLLVAAIGGGAGIWAISAGDTDTPPVATAPTETPPQPGLKPWAEATPRSPAEHALATAAPAVVFLEAIFTGYVRNKQDNALLHPEPFTFSRRCTGVVINRDGHLLTNGQCVAPTVDILLEHALGSLADTLVADGKLKAGEVGGYVRGRQASSAFTGPDAGTEPAVILHGQLNVSQGDLKDDPAIPGTVLRTFTLEEGNLALVKLDRADLPVAELNTSATIAAGTALHVLGYATTDAEYRSATYTVRSAPVEVTEVDIESSVYRINADIGGYSRGGIAIDAQGRVVGMLDNDLLAPERPNRLVVPVSRMTRLLDAAGVANQLGEPDQTYRSALETYFGGDEAKAARQFAEVAEQSPTNALAAAYREAAVAAGGDTAERRPGWAVPVLVVAGVAFLAGLGVLIWSRRRPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7L9</accession>
    <name>F4F7L9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733115.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16770"/>
    <dbReference type="EnsemblBacteria" id="AEB44458">
        <property type="protein sequence ID" value="AEB44458"/>
        <property type="gene ID" value="VAB18032_16770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16770"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_0_11"/>
    <dbReference type="OMA" id="ENDFFRA"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="135" mass="15163" checksum="4B682401E82C0C5D" modified="2011-06-28" version="1">MHAFDVLGDPVRRRILELLADGEQAAGTISEVVRAEFGISAPAVSQHLRVLRESGFVTVRPDGTRRLYAVEAAPLQEVDIWLGRFRQFWSQRLDALATELARGKRQRREPRDNPGNPGETPERRQAAESDSEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Q4</accession>
    <name>F4F7Q4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734343.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22955"/>
    <dbReference type="EnsemblBacteria" id="AEB45691">
        <property type="protein sequence ID" value="AEB45691"/>
        <property type="gene ID" value="VAB18032_22955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22955"/>
    <dbReference type="eggNOG" id="ENOG502ZW25">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098984_0_0_11"/>
    <dbReference type="OMA" id="HVCPRQN"/>
    <dbReference type="OrthoDB" id="1271408at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021441">
        <property type="entry name" value="DUF3090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11290">
        <property type="entry name" value="DUF3090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03847">
        <property type="entry name" value="TIGR03847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="191" mass="20918" checksum="DCB164AB2D76F05C" modified="2011-06-28" version="1">MTHQVHAFEPPERFVAGTVGPPGERTFFLQARGGGRLVSVALEKVQVSLLAEKLEELLTEAQRRFGVELPEAPASVGDNEPLETPVDEEFRVGTLGLAFDADTATVVIEAIAVGEVEAEMELGESEEDEADDVEPDEDLDRLRVRLTPEATREFIERARRVVNAGRPPCPLCGQPLDPAGHLCPRNNGYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Q6</accession>
    <name>F4F7Q6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734345.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22965"/>
    <dbReference type="EnsemblBacteria" id="AEB45693">
        <property type="protein sequence ID" value="AEB45693"/>
        <property type="gene ID" value="VAB18032_22965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22965"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093167_0_0_11"/>
    <dbReference type="OMA" id="YEDICCD"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309150" evidence="1">
        <location>
            <begin position="29"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="20705" checksum="67067C8D6D8D8C45" modified="2011-06-28" version="1">MNTMLRKSVLAIAGLTVAGGLAAGPLNHTDTTTNTSTATVAQATKPDTAKLIPHGVQGNQSHIDLNDEQVANTKAIIAATKKTGMDERAAVVSIATALQESKLENLGHLGDRNDHDSQGLFQQRPSSGWGTVEQITDPEYSTTAFLKGLQQVDGWQNMPLTEAAQTVQVSAYPFHYAQWEQQAADLVAEHWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Y6</accession>
    <name>F4F7Y6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735609.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29451"/>
    <dbReference type="EnsemblBacteria" id="AEB46961">
        <property type="protein sequence ID" value="AEB46961"/>
        <property type="gene ID" value="VAB18032_29451"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29451"/>
    <dbReference type="eggNOG" id="ENOG5031TCK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="WRTFIDS"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="60" mass="6663" checksum="D3DE615F6B19303C" modified="2011-06-28" version="1">MDLTGATWRTATRSGNTDCVEVADNLPDVVAVRDSKDRQGPVLAFTPQTWQTFVGQVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F886</accession>
    <name>F4F886_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10645"/>
    <dbReference type="EnsemblBacteria" id="AEB43247">
        <property type="protein sequence ID" value="AEB43247"/>
        <property type="gene ID" value="VAB18032_10645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10645"/>
    <dbReference type="eggNOG" id="ENOG5031YP1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105034_0_0_11"/>
    <dbReference type="OMA" id="CAIWDYR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="178" mass="19184" checksum="F82514A98786720E" modified="2011-06-28" version="1">MTNDPAALDPAVKVDLWRQRFFEAQAAAEEFILGVHGDEGVSAWIQANSRITADLLQSQRPAGESATVHFMNRLQRQLLLYDSAVTSEPQPSGTVLRNAECGILRYRKQAAGAGVKLTYASPCPYCQELNTAIAARYVESDVTVSCEQAGDGCTWRAESRHASEGDAAGPPDRGGTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8F7</accession>
    <name>F4F8F7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_16990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733157.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16990"/>
    <dbReference type="EnsemblBacteria" id="AEB44502">
        <property type="protein sequence ID" value="AEB44502"/>
        <property type="gene ID" value="VAB18032_16990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16990"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677826_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="406" mass="44622" checksum="28A6CDC1310B9766" modified="2011-06-28" version="1">MSSLATCELQVTRNDQELRLVTGARAEIERRNRTLLDTDNFRHEVLGAGWISDGTDLAAMVAAGVDGWDLEIGEPGPATTAALRLLLADLLPAGAVDELAALADGLRDEPMPWHTEWIPPVPPPLAREGAVWFDVLAPSVNWRQDDTAADPVAHYRHARIIWAPRWCVVVWSGRTGGEGSKYRTWGLPDRRLEDQSAGGSGAERMARVLRAVVRHIEWSVDMVDLELETWENYFLAQAAGDGGLFVGPDFNRLQRHLALLGHGTALNRDAVRTLVRRIEIQPGIPGDVRDLVREKCERFLSQSQAQRRAVRQSFDLIANATSGQQFRLAQERADRDGAFQAIVGILAAVFVAPALIAAFYGANLKGLPGADAREGLWYMLLGSVLAGLISVCLILVVRARSRRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8G4</accession>
    <name>F4F8G4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_17025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17025"/>
    <dbReference type="EnsemblBacteria" id="AEB44509">
        <property type="protein sequence ID" value="AEB44509"/>
        <property type="gene ID" value="VAB18032_17025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17025"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OMA" id="AMSETVQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="494" mass="50282" checksum="1AB57B772025B329" modified="2011-06-28" version="1">MREWLGLAVLALPTLLLSVDATVLYLALPHLTTDLWPTATQTLWIVDIYGFMIGGFLITMGTLGDRIGRRRLLMIGALAFGAASVLAAYATDPTVLIAARALLGVAGATLMPSTLALITTMFRDPGQRGMAIGVWAACFSAGLAAGPLIGGALLELFWWGSVFLLAVPVMVVLLVAAPVLLPEAKDPQAGRIDLVSVALSLAAMLPAIYSLKVIATEGIEVGALVALVASVVFGVLFVRRQRTLADPLLDLRLFTRPSFVGALLALLVGLAVVGVVYLFATQYLQMVSGLSPLAAGLWLLPSAVAMIVTSIAAPVLARKVAPGLLVAASLVVSAVGYVLLAFVDGPNGMALVVAGLVVIYLGIGPMMALGTDLVVSRAPAERAGSAAAMSETSMEFGLALGVAVLGSLGAAVYRSELPGGTPAEATESLAGALAVGNADLVAAAREAFTSALNAVGWAGAVAAVGIAVVTALLVRGPEAGPNQSAMEEAATSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8H3</accession>
    <name>F4F8H3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733173.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17070"/>
    <dbReference type="EnsemblBacteria" id="AEB44518">
        <property type="protein sequence ID" value="AEB44518"/>
        <property type="gene ID" value="VAB18032_17070"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17070"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="18740" checksum="C66294BDEBEB371F" modified="2011-06-28" version="1">MDTATNASLVGAAQMRSTMSQFATGVVVLTVGGDHLHGMTANAFSSVSLEPPMVLCCVGKNAVMHRAITGSGHFAASVLRAGHEPYARHFASRDRPLGSAQFAVGDWMPGALTGAPLLTDSLAWVECALADVYEAGDHSVFLGRVIGSGHRSGAGLLFFDGAFHPTTTWPPSTDAGPTDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8U0</accession>
    <name>F4F8U0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcxB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_29746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29746"/>
    <dbReference type="EnsemblBacteria" id="AEB47020">
        <property type="protein sequence ID" value="AEB47020"/>
        <property type="gene ID" value="VAB18032_29746"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29746"/>
    <dbReference type="eggNOG" id="ENOG5031SGF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1673930at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="96"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="18019" checksum="3E0F398ED5DD52BC" modified="2011-06-28" version="1">MHIRFDVPADPAYPGRVAAALSGDRLRRYGYAGAVLTAVGTIGFVASRGTSWGELISPFWVTMAVGGLLAMLYWPWLQLRARRRSSGYAVDGSYDITDEQILMRSGTESGGIAWDGVARVKGTPDFWIVYVGGMPATVIPRWLMSAADAETLRAFMTERGLLQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F932</accession>
    <name>F4F932_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04670"/>
    <dbReference type="EnsemblBacteria" id="AEB42060">
        <property type="protein sequence ID" value="AEB42060"/>
        <property type="gene ID" value="VAB18032_04670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04670"/>
    <dbReference type="eggNOG" id="ENOG5032QVU">
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    </dbReference>
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    <dbReference type="OMA" id="WDSSLGM"/>
    <dbReference type="OrthoDB" id="1887051at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="149" mass="15689" checksum="742BEC06A6DD6660" modified="2011-06-28" version="1">MSTAQPVPQRRTALGIPWPALLGLALLGLPRVVLHDLGLVHEGTFVNLLLVVVPPMVWIVTAVLRRVPNPFLTLLVLGLIYGVLLALTHQVLWDAAFDAPPTLGGNLGDLAPGTQAVIIRVFAAISSVFTGVLVGAVSGLIAWSLARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F974</accession>
    <name>F4F974_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NLP/P60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_04880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730776.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04880"/>
    <dbReference type="MEROPS" id="C40.007"/>
    <dbReference type="EnsemblBacteria" id="AEB42102">
        <property type="protein sequence ID" value="AEB42102"/>
        <property type="gene ID" value="VAB18032_04880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04880"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034085_1_0_11"/>
    <dbReference type="OMA" id="MYVGDGW"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312817" evidence="4">
        <location>
            <begin position="51"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="231"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="159"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="346" mass="37185" checksum="30DA016E88835762" modified="2011-06-28" version="1">MAHHAPRPPSARPATPGPTTAAPRSRWYRCTTALAALSATAVMLTGGATAAHAEPTVDAIERQIDADWNRLEPLIERHNSTRQDLAGKRREADALAARIAPLEQQVDAAMTRVGALAARAYKGGTVGAVNALLDSRSPGEVVEQIGLLNRYAHFQQQDVREASELRDELTTAKAGLERTIDQLARTEAELAQKRRQIDAEIDRLQRLRLRAYGNGGGGPLRPAPCPAGYPGGPAGVAVKFACAQIGKPYVWGAEGPHAYDCSGLMLAAWARAGVALPHNAARQRQVTASVSRSALRPGDLVFYYRDLHHVGMYVGDGWVVHASRAGQPVKMKRMDTSPIHSFGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9A2</accession>
    <name>F4F9A2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731967.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10890"/>
    <dbReference type="EnsemblBacteria" id="AEB43296">
        <property type="protein sequence ID" value="AEB43296"/>
        <property type="gene ID" value="VAB18032_10890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10890"/>
    <dbReference type="eggNOG" id="COG2273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019533_4_1_11"/>
    <dbReference type="OMA" id="WMLGTPV"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313698" evidence="1">
        <location>
            <begin position="36"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="40"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="287"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="415" mass="45180" checksum="3BB173B2F15ADE51" modified="2011-06-28" version="1">MSVISRRLRRPAAVLVAALVASTLVVPVNATPAAAAIGGLTWQDEFNAPAGTPVDQSKWRFDIGGHGWGNNERQYYTNSTSNAVHDGQGNLVITARRENPANYQCHYGRCEYTSARLLTAATFNQAYGRFEARIKIPRGQGIWPAFWMLGSDFGNVGWPASGEIDIMENVGREPNTVHGTIHGPGYSGGGGIGGSRTIGQPLADAFHTYRVDWEPNVIRWYLDGQEFFRVDPSRLGGSRWVYDHPFFMILNVAVGGNWPGYPDGSTQFPQQMLVDYVRVYGYVPDGNTGTTRIRGQQSGRCIDIPSANPYDGAPLQIWDCNTTAAQAWTFAADGTIRAMGKCMDPAWAGTANGTEVNLVTCNGNPAQRFTLNAAGDLVNLNANRCVDVRDNNPANGGRLQLWDCTGAANQKWSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9F4</accession>
    <name>F4F9F4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_11150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732019.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11150"/>
    <dbReference type="EnsemblBacteria" id="AEB43348">
        <property type="protein sequence ID" value="AEB43348"/>
        <property type="gene ID" value="VAB18032_11150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11150"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OMA" id="PINATEM"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="94"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="36740" checksum="0E03C68B94EA9647" modified="2011-06-28" version="1">MSRATAPEPATRRPPTGRSTTWRDRLHRFDVRYVPYLLIAPFFLLFVVFGLFPMVFNAVVALRHWRLDEPDRTGWAGTENFRRLFTDGDFGNALYNTFGIFLLSTVPQLLLALVIASMLNRRLRAQTWWRVSVLLPYITPITASTLVFNVFFARDLGMANWALGLVGIGTENPIDWRADKLHSWIAIATMVNWKWVGYNALLYLAAMQSIPRDVYEASALDGAGPWRQLWRITVPMIRPVVIFTVVLSTIGGLQLFTEPMLFDLNAQAARGGAGGEWQTVAQLIYKVGWKDLNLGYAAAMSWTLFLVILVVAALNTALTSRISGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9L7</accession>
    <name>F4F9L7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733250.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17465"/>
    <dbReference type="EnsemblBacteria" id="AEB44595">
        <property type="protein sequence ID" value="AEB44595"/>
        <property type="gene ID" value="VAB18032_17465"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17465"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_11"/>
    <dbReference type="OMA" id="IRTHYIE"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="28260" checksum="45D5F4BF7888A0B4" modified="2011-06-28" version="1">MTALRTVTVHGSPVHLMESGTGPAVLMLHGSGPGTTGSGAWAATAQALGTSWHFVAPDQAGFGRTPVPPGSRGGLRLWTEQAAGLMDALGIEHYTVVGHSMGGAVALALAAARPQQVTRVVAVSTMGAPGAPLSADLDAIWAVPASVLGARDMLSRLVLDQTLVTDAAVDARAAAMRAGADAFASLFPPPRARWADDLSLSAQTLAAIRAPVLLVHGAEDRVTPLETAAQPLLAHLPDVRLHVFGRCGHVPAIEHPHEFRQLLSCFLHPDLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA30</accession>
    <name>F4FA30_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_00285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007464872.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00285"/>
    <dbReference type="EnsemblBacteria" id="AEB47141">
        <property type="protein sequence ID" value="AEB47141"/>
        <property type="gene ID" value="VAB18032_00285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00285"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_0_3_11"/>
    <dbReference type="OMA" id="DRMLYIH"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="108" mass="11929" checksum="898D24577A976583" modified="2011-06-28" version="1">MTYIIAEPCVDVLDKACIEECPVDCIYEGNRMLYIHPDECVDCGACEPVCPVEAIFYEDDVPEQWKDYTGANYEFFEDLGSPGGASKIGKVEKDATFVAAQPPRGEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA56</accession>
    <name>F4FA56_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04955"/>
    <dbReference type="EnsemblBacteria" id="AEB42117">
        <property type="protein sequence ID" value="AEB42117"/>
        <property type="gene ID" value="VAB18032_04955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04955"/>
    <dbReference type="HOGENOM" id="CLU_3141980_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="49" mass="5583" checksum="8A2BCF1539886674" modified="2011-06-28" version="1">MVRRDVSGHRAARPIAGRMIGFRYRRNSGHTTMITLTSEVLLSLWSDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAB6</accession>
    <name>F4FAB6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05255"/>
    <dbReference type="EnsemblBacteria" id="AEB42177">
        <property type="protein sequence ID" value="AEB42177"/>
        <property type="gene ID" value="VAB18032_05255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05255"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003361_0_0_11"/>
    <dbReference type="OMA" id="MGNNVML"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020958">
        <property type="entry name" value="DUF3686"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12458">
        <property type="entry name" value="DUF3686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3686" evidence="3">
        <location>
            <begin position="67"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_5" evidence="2">
        <location>
            <begin position="1328"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1690" mass="185760" checksum="120BDF1A4B21172B" modified="2011-06-28" version="1">MSEPTAGSAAGRTSSGRPGPVPLIDEAEAAVPTAGADGTTGSPGAAPGLDDGSYEVLRRRLATQAAELARRAEALNARRLEVFGSTELRLLSTERIRTEHNCVPRDIVSVGGLMLFGYNVFIGLKPETSVDDVFSLHRFVREPVTDAFRFDEAGHDELPGLLRHPQFVRDFSELYRYYRQARLLQLRRVDGRLLAVFQTGPRTEDIRVLRWQVGVDGVPEYLDSRGERDHVFPPSHDFEWIETTREDHVLGRHPHISIGGEVFVETVGGTLTVKVENNTEVGEGIYSEPVDEPLQSLADADVHWARVGTLILMRLRPYKETQWRHLVFNTITREVVRLDGIGVACQRLPEDHGIIFPGGYHLATGVTRTFDAEVAGLEFERVVRSPNGEDVLYVFHARADGRSLLLPYNAIRKEVAAPIPCHGFSLFDDGTLVVFRAVSEEPTRVHPMQIWQTPYVSDAYAAAQPAGTGPLERVGNADLVRGISDSLSAARMVEGTATAEVYEALIAACGRIGDHYHWLGEEELGDLATPLAGLRRTATAVLEEHEKVRTLTERARAEVEASAEQIASLARRARGEAPLTADDWVAQLGGLRRARGHLETLRELRYVDHARIDELAGRLDEELAVAGRRAVEFLRRDEAFTGYQQEVDRLATRAAEIGTVAEAGTVGDELAARTEGLQTITDVVGGLDIADATVRTAILGRVGEVLGAVNRARAVLDKRRRELAAVEGRAGFAAEFALLGQAVAGALAASDTAERCDEQLGRLLLRVEELESRFGEFDDFLAELATRRTDIYEAFSSRKQALLDERARRADRLVASAERIMVSVHRRAGTLGSLDEINTYFAADPMVGKLRTVVEELRTLGDAVRAEELDGRVRAARQEAGRGLRDRLDLYADGGETIRLGRHRFAVNTQPIDVAVVPHDGRMVVAVTGTDYRAPVRDEQFQQTRRFWDQLLVSESPQVYRAEHLAATILSAAEAGRDGLTLDALHTAAVDGDDLRELVRRIAETRYDEGYERGVHDHDAAEILRVLLRLHAGAGLLRYPPADRAAACLFWRYGTDEATRTAWTARAASLARARERFGRPDGEDAADRLCAELATAIDGFLRETGLPVPTGGTGLAGEYLFAELSAPPVRFVTGSGAQTMLERFRRALGGAQSRSSREFDDDLRALGGDLAGRYQLVDAWLTAFLATDDGALSSYDLPEAIAVELCGTELPRSDSAAAMTETVGGLLGAHPRIEGSTLDVRLDEMLARTRAFRTELIPAYRAYQRQRNALVDAERDRLRLDEYRPKVMNAFVRNRLLDEVYLPLIGDNLARQLGATGDGKRVDQSGLLLLISPPGYGKTTLMEYVASRLGLVFVKVNGPALGTKVTSLDPAEAPDATARQEVEKISFALELGNNVLLYLDDIQHTNPELLQKFISLCDGQRRMEGVWNGRTRTYDLRGKRFAVCMAGNPYTESGKRFRIPDMLANRADVWNLGDVLSGREEVFALSYIENSLTANPVLAPLAGRDRADLELLVRMARGDDSVRPDQLSHPYPPVELEQIVSVLRKLLRVQQVVLANNQAYIASAAQSDDARTEPPFQLQGSYRNMNKLAERVVPVLTDDELEAVIDDHYLGEAQTLAAGAEANLLKLAELRGRLTGEQAARWAEVKDAFRRTRALGGAGDDPVDRAVGALGLLADRVNSIATALTRTTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAF5</accession>
    <name>F4FAF5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">leuD</name>
        <name evidence="12" type="ordered locus">VAB18032_11320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732053.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11320"/>
    <dbReference type="EnsemblBacteria" id="AEB43382">
        <property type="protein sequence ID" value="AEB43382"/>
        <property type="gene ID" value="VAB18032_11320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11320"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081378_0_1_11"/>
    <dbReference type="OMA" id="AFTTHTG"/>
    <dbReference type="OrthoDB" id="1384217at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="21470" checksum="F82E5F093EC2B856" modified="2011-06-28" version="1">MEKFTVHTGTAVPLRRSDVDTDQIIPAVYLKRVTRTGFADGLFSAWREDPGFVLNDQSYSGASILVAGPEFGTGSSREHAVWALRDYGFRVVIAPGFGDIFRGNALKEGLLPVELELKAVEEIWGLVESDPATAITVDLATRQVQAGAATWSFPLDDFSRWRLMEGLDDIGLTLRHEAQISTFEATRPSFLPRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAX4</accession>
    <name>F4FAX4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734589.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24195"/>
    <dbReference type="EnsemblBacteria" id="AEB45937">
        <property type="protein sequence ID" value="AEB45937"/>
        <property type="gene ID" value="VAB18032_24195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24195"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_1_11"/>
    <dbReference type="OMA" id="FVAMMQF"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307766" evidence="1">
        <location>
            <begin position="28"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="547" mass="61427" checksum="5F415A0E62C63834" modified="2011-06-28" version="1">MFRRSWRHTAAVATVALLALSSVTACGDDSSDAQDLSENRAGAMENYAAGTQFKATEPLSFSVLYNNHPNYPLKNDWLFWKELTARTNVTLDPVAVPLSDYNQKRSLLIGAGDAPLLIPKTYPPDVHAYVSSGAILPVSDYLDLMPNLKDKIEKWNLKPELDTLRQADGKFYLLPGVHEKPWHEYSLVVRTDILDELGLEIPKTWDELYTVLKAMKAKYPDVYPFSDRYSQPNPAGNLLNLLAVSHGLEGAGWNFQHVSWNAGAQKFEYTAATEHYRHILEYLNKLVAEKLLDPESFTQTDDLARQKLANSKSFVISGNAQALVNDYRPDLAATNPKAKITKIPLPVGPAGEINPASRLENGMMISSKARDSKNFVAMMQFVDWLWYSDEGQMFARWGVEGTTYVKDAAGKAGLAEDVDMIGLNPGAPKHLQKDFGFANGVFAYGGKPELVQAFFSAEEQEFQKVMNARTPKSPPPPYPLTDEEREQVSLWETPLKDHVYQATLQFALGQRDLAQWDAYVTELKSKNMDAYLDTVNKAYERYRDEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAX9</accession>
    <name>F4FAX9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_24220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734594.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24220"/>
    <dbReference type="EnsemblBacteria" id="AEB45942">
        <property type="protein sequence ID" value="AEB45942"/>
        <property type="gene ID" value="VAB18032_24220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24220"/>
    <dbReference type="eggNOG" id="COG3661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007125_1_0_11"/>
    <dbReference type="OMA" id="DNNGWGQ"/>
    <dbReference type="OrthoDB" id="207695at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Glyco_hydro_67M" evidence="6">
        <location>
            <begin position="174"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67C" evidence="5">
        <location>
            <begin position="487"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="717" mass="79586" checksum="77218BB2137C2AE1" modified="2011-06-28" version="1">MRRHRDQVRMSTPDPTDVHPAWLPDEAWRAIGVRRILVRGEGTLVDTVQAEVERATHRYGGAVWRNPTDVDLPSADLVLALTGAPPPDSPPAPEPGPPETSGTLASTAVATAKAQLDTATAQVGESLGAEGFVVARHAGVTVVLADAPAGLLYGLFELVRLGAAGFGPTHPVRVHRPAMARRMLDHWDNVDVHPVMGQVERGYAGGSIFWRDGRPRGDVARVTAYARLLAACGINAVSVNNVNVHATEAQLLTERLDDVAELADLLRPYAIRVHLAVTFAAPVVLGGLPTADPLDPAVRDWWAETTARVYARIPDFGGYLVKADSEGQPGPFSYGRDHADGANLLAEALAPYGGVVHWRAFVYNHRQDWRDRSTDRARAAYDHFAPLDGRFRDNVIVQVKHGPMDFQTREPVSPVIAAMPGTRLAVEFQVTQEYTGQQRHVCYLAPWWSEILRFAPWGDDGRTVADVAADGGGLVAVSNVGDDRFWTGHPLAQANLYAFGRLCWNPRLGPQAVLDEWIDLTFAPDTRVDPDLLRRTLHEIMDDSWRTYERYTAPLGVGFMVRPGHHYGPDVDGYEYTPWGTYHFADRDGVGVDRTRATGTGFTGQYPPPFAERYESVETCPDELLLFFHHVPYGHLLHSGSTVIQHIYDTHFEGVREVEAMCRRWEWLARLVDPAVHARVTERLAEQLRCAREWRDQVNAYFHRKSGIPDAHSRMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBN9</accession>
    <name>F4FBN9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732170.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11935"/>
    <dbReference type="EnsemblBacteria" id="AEB43501">
        <property type="protein sequence ID" value="AEB43501"/>
        <property type="gene ID" value="VAB18032_11935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11935"/>
    <dbReference type="eggNOG" id="ENOG502ZGVP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1657108_0_0_11"/>
    <dbReference type="OMA" id="THEAHAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="15021" checksum="67358D22516A6D5F" modified="2011-06-28" version="1">MLRAGALLALGGAAAPLTGCGLLDRDEPPRPDPLAPLIDESLRLAAGLRSAADAHPDLAARLVPLAETHEAHATELARVTGTALPSGSPSGSAAPPSPEQPAGRAATLSALRKAERAGRDSATAACAAAPGDRAALLGSIAAARATHLEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBQ8</accession>
    <name>F4FBQ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase involved in albicidin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_18030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733363.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18030"/>
    <dbReference type="EnsemblBacteria" id="AEB44708">
        <property type="protein sequence ID" value="AEB44708"/>
        <property type="gene ID" value="VAB18032_18030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18030"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_4_1_11"/>
    <dbReference type="OMA" id="HLIGIWA"/>
    <dbReference type="OrthoDB" id="1213908at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="145"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="347" mass="37843" checksum="8323C9E995AC3AB1" modified="2011-06-28" version="1">MPATTAPPVTRERLNGLMQAYKSTSLLRTAVELGVFDALADGPATADALATRLGAHPRGMRILLDAMVAISLAGVEDGTYRLPPGADQFLVSKSPYYLGDMTKVISSDWEWDALKRLTDAVRHGGTVMDEHAETAEYEYWVDFASFASAIATPTARVMTNALQEFAAARPSLRVLDLACGHGIYGYTFAQRHTQATVTSLDWENVVPVAARHAERLGVADRVEYRTGDMFTAPLGGPYDVVMLTNVLHHFSEERGTDLLRRAREALKPDGRLALVGFTTGDGTPAEDPAPYLFSILMLVWTSEGEVHSRAAYDRMLTESGFVEPELHSVAHLPLRVLIASPAETSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBR1</accession>
    <name>F4FBR1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative multi-domain non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733366.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18045"/>
    <dbReference type="EnsemblBacteria" id="AEB44711">
        <property type="protein sequence ID" value="AEB44711"/>
        <property type="gene ID" value="VAB18032_18045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18045"/>
    <dbReference type="eggNOG" id="COG2521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1271838_0_0_11"/>
    <dbReference type="OMA" id="LMWASAD"/>
    <dbReference type="OrthoDB" id="1196895at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="217" mass="24012" checksum="3931CD3610030648" modified="2011-06-28" version="1">MTSTPDISLVHDANGGVTLLIDGVQAMQGWEAELMWRSADLLCADGGDFLEVGLGLGYSALRIAGHPGTRRHTVIEKHADVIDLFRTGHPAVPGNLEIVHADFFDHLERLPQAAYDGIFFDPELPRDLFEDRALLDEFMPRLINALRPGGRFVPMFALDGAVPDAATCTTTPAAMLDRYLRYFDRVEMVRHPYRAYVGTEYTPSDSGDAFILCFGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBR4</accession>
    <name>F4FBR4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733369.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18060"/>
    <dbReference type="EnsemblBacteria" id="AEB44714">
        <property type="protein sequence ID" value="AEB44714"/>
        <property type="gene ID" value="VAB18032_18060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18060"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146613_1_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="105" mass="12067" checksum="468FDC055E32A2B3" modified="2011-06-28" version="1">MTIDTTTAIRVILWYRTPERDVAGLAETYRQIGEHLAGTPGMVSSELLVSRDEPGVLMVTSRWRTAEDLQRWVHSDTHRHTTPLRPYLDTGRTRPWETFSVVSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBU6</accession>
    <name>F4FBU6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733401.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18220"/>
    <dbReference type="EnsemblBacteria" id="AEB44746">
        <property type="protein sequence ID" value="AEB44746"/>
        <property type="gene ID" value="VAB18032_18220"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18220"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OMA" id="FRHAREW"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="319" mass="35097" checksum="647F30F896702540" modified="2011-06-28" version="1">MSISTAPAAEPAAATTPPAPVRRTRRFRHAREWWLGALLVLPALALAFTFKLVPLVRGVTTSFESSSGFGDSSFAGFDNYTRMFDDPMVLASFRNALLVVATLPVWIVVPLVLAVLIHQRAPGWKFFRAVYFIPYTIAPIVVGIMFRQILAPDGPINALLRTVGLEPLALEWLNGRNSALFSLVAVALWSFFGLGVMTYLAGLATIPDEVLEAAYLDGAGFWRRLFSVVVPMLRPTVAYWSVLCASGVLIWLFPLIYALTQGGPGDATMLPEYLVFLTTFQFLDRGYGSAIGIALFVFVALISVFSVRHMFKEGTRKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBY4</accession>
    <name>F4FBY4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733439.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18410"/>
    <dbReference type="EnsemblBacteria" id="AEB44784">
        <property type="protein sequence ID" value="AEB44784"/>
        <property type="gene ID" value="VAB18032_18410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18410"/>
    <dbReference type="eggNOG" id="ENOG502Z8MJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074815_0_0_11"/>
    <dbReference type="OMA" id="YEVWRQR"/>
    <dbReference type="OrthoDB" id="1529280at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012964">
        <property type="entry name" value="DUF1702"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08012">
        <property type="entry name" value="DUF1702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="315" mass="34598" checksum="4B338A6D76D36404" modified="2011-06-28" version="1">MAGLWRTLRAQLMTPDIAETTMSRRGFHVKDEPARQRLESVGASFLTGFRAAVEAREESDIGRLDLIERQFRGFAYEGAAMGYAVLDGVAGGNRTTRFLTGAGAPHIYMAYVGIGWAFAKVPRWRWRALAAPDPLLRWLVLDGLGFYRAYFETDRYVRQQTVAPVAWPPDLPGDYPRRALDQGIGRASWFVAGADPDVAADIIGRFDADRHADLWSGMGLAATYAGGADPDDLKKLAVHAGRYRPQLAQGATFGAQARLRAGLVTEHTPLATEVFCGCSPEEAAAVTDRARENLPPDGAEPAYEVWRQRIQAQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBY9</accession>
    <name>F4FBY9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734639.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24445"/>
    <dbReference type="EnsemblBacteria" id="AEB45987">
        <property type="protein sequence ID" value="AEB45987"/>
        <property type="gene ID" value="VAB18032_24445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24445"/>
    <dbReference type="eggNOG" id="COG2356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043034_3_1_11"/>
    <dbReference type="OMA" id="RTAYRCT"/>
    <dbReference type="OrthoDB" id="1510738at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307785" evidence="1">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="210" mass="22997" checksum="60BA9C56A12A7B79" modified="2011-06-28" version="1">MAHVRKAAVTLVVALALSLVLVPRPAHATPPNIPSYATALSRLNSLTVAAESHQSSYNRDLFPHWSTVTGTCNTREQVLKRDGTNVTVDASCYPTSGSWYSPYDGLTRTSPTQIDIDHVVPLAEAWRSGAWSWTTSRRQTYANDLGGPELWAVTSTVNQAKGDKDPAAWKPPRAAFHCTYARAWIQVKWYYALSVDSAEKSALASMLSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC03</accession>
    <name>F4FC03_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734653.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24515"/>
    <dbReference type="EnsemblBacteria" id="AEB46001">
        <property type="protein sequence ID" value="AEB46001"/>
        <property type="gene ID" value="VAB18032_24515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24515"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014290_1_0_11"/>
    <dbReference type="OMA" id="FIHMVSR"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="514" mass="59069" checksum="ADF53E1B95C71E2D" modified="2011-06-28" version="1">MVSNEHRYVIIGAGPAGVQLSYYLQQHGADYLTLESGDSPGGFFRRFPRHRRLISLNKVHTDSTDPEIRLRWDWNSLLNDSPDLLFPNFSKEYLPAADDLVRYLAEFQRHYQLNISFGTTVEQITRTADGFTLRTDQGEVRARCLIVATGWGKPFVPAIKGIEHAIGYEDMVVDPEEYEGQRVLVIGKGNSAFETASAILGRASMVHLASRHPLKLAWNTKHPGDVRGQYGAILDSYQFKTLHSVLDCTIDEIRPVDGRFQVSITYTHADGETAVLDYHKVVRCTGFQMDTSLFDETCRPDMVRDDRMPDLRPDWQSTNVDGLYFAGTIAQARDVKHASSPFIDGFRYNLRTFTRMLRERYEDVPLSYATTPADPASLTKLMLDRVNWSSALWTQFEYLCDAFVRDDTTGDFRHYEDLPEDYAVERFADATQWYTLALRWGRDEYGDVFAIERHPTPDRARESAFIHPVIRRYRGTELLAEQHLLEDLLAEWRRPDRHVEPLVEFLSKDFTNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC25</accession>
    <name>F4FC25_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734675.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24625"/>
    <dbReference type="EnsemblBacteria" id="AEB46023">
        <property type="protein sequence ID" value="AEB46023"/>
        <property type="gene ID" value="VAB18032_24625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24625"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_2_0_11"/>
    <dbReference type="OMA" id="GGSVWFL"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="841" mass="86988" checksum="588CDF5021E0FAC3" modified="2011-06-28" version="1">MLGLALRMLRHRIGTAIATLVALACGVMILMSVGLLVESGLRYTPAPQRYAAADIVVANHDITITGKEFDGTTITTRVRLPEGGTVPVDLAEQLRRVPGITIVAVDRSIRAVVPIAATSHTLAHGWSSAALTPYRIVDGRQPSADGEVAVDLRLAKAAEDEIRPGDRIPVLVGGAVRTYTVSGVVERAVDGDWPAALFFTDRHAAALNPHPGRADAIGIVLASDADTSAVVAEVRRLSSEAGARVYTGADRGTLTQSEALAARDLLVQVGAAFGGYVVALVVFVVAGTVGLAVRHRRRDLALLRAVAATPGQVRGMLLAEVVQVSIVAVVVGIPAGLFVTDRVHRQMIARGFVPDGFPISGGVLSAVAVTAVTLLVAVTAALIAAGRTVRIRPTEALGEVAVEPSRNSRTRLVIGLVTLGAGVSLTMVTTVARGPAALGAALGMLYVFVLAAALLAPWINRYAARALGPVLRAVWGDSGYLAAANLRANAQGMVTVLTALVLAVGFGGSVWFLQDNLQRQTVAQTRDGMLAQHALLSPVGLPQSAVADARAVPGVVAATGIRRTSVITRVMGEPQEVSAQAVDPDGADRTLDLTVTEGRLADLRGATVALSTLQASSQGAELGDQVAMWLGDGTPVTLRVVALYERGLGFGDVTLNRETVDGHTATNLDDQVLIRTEGGGAALTDLVDRHPGSSLIDTAAINGELAKDLAISAWLNKLLIGVMVGYAALAAANTMVMAALARGRELALLRLVGVTRRQVKRMVHAEQVGLLGTSLLVGGAIAAITLVSVVRTLTGEPVPYVPTAGWISIIGGTALLALATTVLPIGALLRTPPVDGIGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC65</accession>
    <name>F4FC65_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.136</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ADP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nnrD</name>
        <name evidence="17" type="ordered locus">VAB18032_00800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 15">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 15">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="14"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00800"/>
    <dbReference type="EnsemblBacteria" id="AEB47244">
        <property type="protein sequence ID" value="AEB47244"/>
        <property type="gene ID" value="VAB18032_00800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00800"/>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_0_11"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 15" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="385"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB47244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="472" mass="47418" checksum="547D152927DEDB23" modified="2011-06-28" version="1">MAELPPGTLMQRAAAGLARRCALLLAERGGVYAAPVLLLVGSGDNGGDTLYAGARLAQRGAAVSALLLTPERAHADGLAALRAAGGRVVAHPPAVVDLVLDGIVGIGGHGGLRETAEQLAASLLDHAGRDGARATVVAVDVPSGVAVDTGDVPLTASGRPNAVRADVTVAFGALKPALVVGPAAALAGQVELVDIGLTPWLRGTPALHVVEWSDVAQWWPRLGATSEKYTRGVVGVATGSATYPGAAMLSVGGALAGPTGLVRYAGGARDDVVREHPSVIVTGRVADAGRVQAWVCGSGLGTDERATTELRTVLAAPVPAVLDADALTLLVDGSLADQLRRRDAPIVVTPHDREFTRLCGETPGADRVAATLRLAAWMNAVVLLKGDRTVIGTPDGRAYVNPTGTPALATGGTGDVLAGLLGSLLAAGLPAERAAASAAYLHGLAGREAARSGPVTAPDVAAALRPVLARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC76</accession>
    <name>F4FC76_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00855"/>
    <dbReference type="EnsemblBacteria" id="AEB47255">
        <property type="protein sequence ID" value="AEB47255"/>
        <property type="gene ID" value="VAB18032_00855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00855"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_4_11"/>
    <dbReference type="OMA" id="DGPPCCY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="3">
        <location>
            <begin position="582"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="697" mass="74079" checksum="4DE1371C52056120" modified="2011-06-28" version="1">MSVLPRQFPTNRGGLCQKGWTSAELLTHPDRLTTPLLRDPASGELRPASWEAALDRIATGIGEVQRRHGRDAVAVFGGGGLTNEKAYALGKFARVTLGTRNIDYNGRFCMSSAAAAGMRAFGVDRGLPFPLSDLGHADTLLLVGANPAETMPPLVRWLTELRQRGGTLIVVDPRVTATARQADLHLQPLPGTDLAVANALLHLALTEGYVDDDYVATRTTGFTDVRRTVAGWWPARAEALSGVPVADLEATARALGTAERAIILTARGAEQHAKGVDTVTAFVNLALALGLPGRPGSGYGCLTGQGNGQGGREHGQKADQLPGYRRIDDPAARAHVAQVWGVSADDLPGPGVPAYQLLDSLGTSDGPRALLVFGSNPVVSAPRAARIESRLRELDLLVVTDLLLSETAALADVVLPTAQWAEEDGTMTNLEGRVLRRRALRPPPPGVRTDLAILATLTTRLKGRAPSYRLVHSKGPLLTADSAADSAAEAAVDGEREALAADPRTVFAELRRASAGGIADYAGIDWDRIDAADGVFWPCPSEDGPDSPRLFADGFPTPDGRARFHPVEHRPAAEEVCAEYPLHFTTGRVLAQYQSGTQTRRVAALRQAAPDAFVELHPDLAGRLGVADGEPVRVLSRRGEFRAPARLSSAIRPDTVFAPFHWGGAARANSVTNDAVDPISGMPEFKICAVRVERVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC86</accession>
    <name>F4FC86_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735909.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00905"/>
    <dbReference type="EnsemblBacteria" id="AEB47265">
        <property type="protein sequence ID" value="AEB47265"/>
        <property type="gene ID" value="VAB18032_00905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00905"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_2_1_11"/>
    <dbReference type="OMA" id="FWKLRVP"/>
    <dbReference type="OrthoDB" id="916788at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="30367" checksum="3EB089B527D7C8D8" modified="2011-06-28" version="1">MTDVRPRQTAGSVPEPLHAVPRGRRVRAGDLRLATVAALLPAVGLLVAFGLWWLVARLELIHPAALPPPGSVLSAFLERPDRLLEHTAVTTRAILVGFALSAAAGVLIGLALAASRTVERMFTPLLVAVNAVPKITLGPLLVVALGWGQKPILTMVFLLCFFPIVLSTATGLTTTPAELAELVRSYNASRWQSFRKIRFPAALPQIFVGLKVAMPLAAIGAVIGEFQAGEGGLGYVIQQYAGVGDTATAWAAIILIALVSILFYGALVLIERFSLPWVRETTSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCJ8</accession>
    <name>F4FCJ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_05995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730998.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05995"/>
    <dbReference type="EnsemblBacteria" id="AEB42325">
        <property type="protein sequence ID" value="AEB42325"/>
        <property type="gene ID" value="VAB18032_05995"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05995"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_11"/>
    <dbReference type="OMA" id="SFRMPRI"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="363" mass="37015" checksum="627F3D3DA9037A11" modified="2011-06-28" version="1">MRQALKRGPSVSPATRPAGLRKRWLAAGVVAVLVAVVAGVSLGPVSLPPGSVALELLNLLPGVHVDSGLTEREVAIVTELRLPRVVLGLLVGGLLALAGGAYQGVFRNPLADPYLLGVAAGAGLAVTVVLTIGGVGASGALTGLPPTIPLAAFVGSLGAVIMTYLLGAAGGRSRSPAALILAGVAVSAFLSAGQTYLLQRNADSIQAVYSWLLGRLATAGWQDVRLVLPYFLITTVVVLLHRRELDVLSVGDDEAASLGLHPQRSRYLLIAAASLGTAAAVSASGLIGFVGIIVPHTVRMLAGSSYRVILPLSLLFGGAFLALTDVVARTAAAPQEIPIGVVTALLGGPFFVLVLRTARRVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCL5</accession>
    <name>F4FCL5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ordered locus">VAB18032_06090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731015.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06090"/>
    <dbReference type="EnsemblBacteria" id="AEB42342">
        <property type="protein sequence ID" value="AEB42342"/>
        <property type="gene ID" value="VAB18032_06090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06090"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_0_0_11"/>
    <dbReference type="OMA" id="VRNFENL"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="236" mass="25515" checksum="914954A63CC3F6E9" modified="2011-06-28" version="1">MSRSPQGQRASLDKQPHEVAAMFDGVAARYDLTNTVLSFGQDRFWRRATRSALELRPGDRVLDVGAGTGVSTEELAHSGAYAVGADLSLGMLYAGKRTRPQVPLLAGDALRLPFADASFDAVTISFALRNVNDTDAALRELARVTRPGGRLVVCEFSTPVNPAFRTVYLSYLMRSLPAVARSVSSNPDAYVYLAESIRAWPDQAALAARVQAAGWGRVAWRNLTGGVVALHRGIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCQ1</accession>
    <name>F4FCQ1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732214.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12155"/>
    <dbReference type="EnsemblBacteria" id="AEB43545">
        <property type="protein sequence ID" value="AEB43545"/>
        <property type="gene ID" value="VAB18032_12155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12155"/>
    <dbReference type="eggNOG" id="ENOG50322G4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1538348_0_0_11"/>
    <dbReference type="OrthoDB" id="2150581at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309242" evidence="2">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="19820" checksum="AE802237EC45B709" modified="2011-06-28" version="1">MTYRKILPAVVLLSATVALTACGDDPDRPSTAAPTVTSADSTAPPPPSPEATATAAAGPESTGAPSDEASTESSSPKLPLSPPPIELPPRQADAPSAREVIAAFRAAGLKVANSRDRSDECGPDGLGLGCSELVVTDGIAVYVFPDEGSATDMAELWDGVSYRKGTVVLNYLKASTPKAERPRYEKVLADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCQ3</accession>
    <name>F4FCQ3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732216.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12165"/>
    <dbReference type="EnsemblBacteria" id="AEB43547">
        <property type="protein sequence ID" value="AEB43547"/>
        <property type="gene ID" value="VAB18032_12165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12165"/>
    <dbReference type="eggNOG" id="ENOG5031RXD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2060467_0_0_11"/>
    <dbReference type="OMA" id="VHYFVLR"/>
    <dbReference type="OrthoDB" id="2011661at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="119" mass="13046" checksum="DA07C91587132474" modified="2011-06-28" version="1">MAVEQRGPGSGTDVLIRKVDSRVVALRAGLRGPDLELAERLASCLRELVVVTAQASAADRAQVRVAVHYFVLRRESRGRLLSVRSLTATQRLVNEAARRIGRPDLMVEPARDPARPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCS5</accession>
    <name>F4FCS5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12275"/>
    <dbReference type="EnsemblBacteria" id="AEB43569">
        <property type="protein sequence ID" value="AEB43569"/>
        <property type="gene ID" value="VAB18032_12275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12275"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012961_0_0_11"/>
    <dbReference type="OMA" id="WAFDQFY"/>
    <dbReference type="OrthoDB" id="379641at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="794" mass="87229" checksum="3E228B8493600EFC" modified="2011-06-28" version="1">MEAMVDDKVLEAQQWVNSTYGAVPGYNRCPENGRTGWSTMYSLTRGLQHELGITSLSDAFGPTTLSRLAALGAIGPDTTNPNIVNIVQYALFCKGYWGGPGDGVYGVDTASAIAELKYNAGLDASDTNVQPKIFKALLTMDAYVVLAGGTETIRSIQKWLNSRYFSRRDFFLIPCDGIFSRDVQKALFLAIQFELGLTDDEATGVFGPGTQAGLRNNLLSQGSSGIFVSIFTAAMVFNRIRLSNGNTYANFTSSFTSSVASAVSDFQTFSALLPPNGRGDFATWCQLLVSTGDPSRPGTAVDCITTITDARAKTLYSNGYRFVGRYLDEKPWGTLNKRIQPGELDTIFANGLKVFPISQYYGEVVSYFTYSQGFQDAVDAHIAATGYGFSTGTVIYFSVDYDATQDEIESHILPYFRGVVAGLADRGKKYIHGVYGSRNVSAQVTAHTYARWSFVSGMSTGFSGNMGFPLPENWSFNQIQTLWLGTGDGRIEIDKNIYKPGSDPAVASVNDPISEADTFVGYISTLLSWARSYGGNRPADQLVMEFLRHEDYNSEQWKLLIGSIDEGFKNHVLDRLRANNMHMIREFRDPFYGVDIKVSHLGASCNAAYLLPQPAGTYTNRGDVGGWGGDWMTFYGEWRRDSDSYSSGRTYCHEKLAKVDGVGTFKLRDLIEDADAYNIAKDVRNGTSIWASMYVNYSGGGHLSRFKRFYEGRFVNAANAKAISRDILLTTADPILSTGRAYLIQTTGGVPTLMPHLLPSNKLDEFCQGFADMLLDRVGQENARVAALRAQGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCV3</accession>
    <name>F4FCV3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Erythronolide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18415"/>
    <dbReference type="EnsemblBacteria" id="AEB44785">
        <property type="protein sequence ID" value="AEB44785"/>
        <property type="gene ID" value="VAB18032_18415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18415"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553154_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="493" mass="52509" checksum="6AC784ECAAA88A1C" modified="2011-06-28" version="1">MAFAARFTRAVLVHDPGRLLVTTTTLSPGETPGLDEPRDRSAPLLPAAHVLEALAQGWAALTGHRGPPVFEAVEFGAPLVVGEDVVRLRLTAAAEPVANAVVVTLRGEHRGRQVTYAHARLRHPGAGRSAVPASAVPSAAGLPVPTALPVPPVRVGGLAPYRPPRAFFIEAGASGRRLRYREITASGCVLELTAGDAVGSLAAVAGPLVLGDPGVRDAFLRALHPWAPDTVLQPLGVDRIWLAGAGPYEHVTLRATRRVEDDDVHRFDLETLAGGRIVERWTGLRLRPLPVRRATGPWPAQVLGPYLRRRLAALTAHDVAAVLEPGLRRGWRRQHTALAVSRLLGDGTTVRYRRDGRPEVGGGWWISAAHGAGHTLAVAARTPVGCDLETVVERTPVEWRQLLGAHHALAELIVAETGESPHRAGTRVWSALESLHKVGVTAFTPLTYDRDTSDGWLLFSAGGWRVSTCATGLRGGPDELVVAVAARHQPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDA7</accession>
    <name>F4FDA7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46137">
        <property type="protein sequence ID" value="AEB46137"/>
        <property type="gene ID" value="VAB18032_25195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25195"/>
    <dbReference type="eggNOG" id="ENOG50346I7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1795669_0_0_11"/>
    <dbReference type="OMA" id="DYSYEVR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036614">
        <property type="entry name" value="RusA-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="144" mass="15436" checksum="EAA5187094DFFB6D" modified="2011-06-28" version="1">MVQDTRTLALTFEVSGLPPVKTEALSIFAAGHRQATRVRALLQAACEAAQRTGWTPLSGPIEVDLTLRCPPGHRTSDASTLLGGVCAVLQDKKRVANIGLAHLGVLVDVAVYGDDKQIRRLSYAEEPAEEFSYQVRVAAVPEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDC6</accession>
    <name>F4FDC6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735973.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47337">
        <property type="protein sequence ID" value="AEB47337"/>
        <property type="gene ID" value="VAB18032_01265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01265"/>
    <dbReference type="eggNOG" id="ENOG5032ZAK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1739490_0_0_11"/>
    <dbReference type="OMA" id="REFTFRI"/>
    <dbReference type="OrthoDB" id="1690756at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="170" mass="18485" checksum="0D4906464085D4DA" modified="2011-06-28" version="1">MHDALARLQDAAALWSVNPSTAADVIDTACDCLVVGIDSPTLRIIAGISPTRGNESDELRRWLEGALAELSLNYYPAGSREGEEAALRVMARRLLTQTIAPRDLTSWAYRFVTWDGTPLAADLIALDNAYDYVDSVYNGHPYTSTTSADLDADVMAEARRLVGDTTALSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDW0</accession>
    <name>F4FDW0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxyribonuclease/rho motif-related TRAM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_12635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12635"/>
    <dbReference type="EnsemblBacteria" id="AEB43641">
        <property type="protein sequence ID" value="AEB43641"/>
        <property type="gene ID" value="VAB18032_12635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12635"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_0_11"/>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="422" mass="44756" checksum="108E8669EA883D93" modified="2011-06-28" version="1">MNEVTLPVQQSEAADGRGGLTEAEQVELTVAAVAPGGHCVARVDGQVVFVRHALPGERVVAEVTEVHRGFVRADAVRVLEPSPDRVEPPCPYARPGRCGGCDLQHVAVPAQLRWKTDVVREQLIRLGGLDEAGCDALNVRVETLPGGPLGWRSRVRYAVDAAGRAGLLKHRSHEVVPVDRCLIAHPAIQDQPVLTSSGTRWPADDAVEVVASTGGDVTVTASTAGRTRRVSGPERVRELAADREWHLPASSFWQVHPAAADTLVAAVLELTGPKPGERAWDLYGGAGLFAAALAERVGESGRVTLVEAAGDGVAAARENLRDLAQVEVVAARVETALARRRITGPVDVVVLDPPRSGAGARVVRDVVAAGPRAVAYVACDPAAFARDLRVFTDLGWRLAALRGYDLFPMTQHVELVGLLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE97</accession>
    <name>F4FE97_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_25325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734815.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25325"/>
    <dbReference type="REBASE" id="34486">
        <property type="entry name" value="VmaORF25315P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46163">
        <property type="protein sequence ID" value="AEB46163"/>
        <property type="gene ID" value="VAB18032_25325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25325"/>
    <dbReference type="eggNOG" id="COG0610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010804_0_0_11"/>
    <dbReference type="OMA" id="VQIIVEH"/>
    <dbReference type="OrthoDB" id="25184at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="282"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB46163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1057" mass="117267" checksum="83FC177C2DE49931" modified="2011-06-28" version="1">MADHNEVVFESEICAYLESHGWLYSTNDTGYDRERALFPEDLFAWLEQTQKPAYTKALKAAGSQAKFLDVLTTALDKPLEHGGGTLNILRNGVQYIGGGRLKMAQFRPDTSLNATTNEQYAAMRVRVMRQVHFSTADRRSIDLVFFVNGLPVATVELKTDFTQSLDEAINQYRKNRHPLTNGRPEPLLSFGHRALVHFAVSNDLAAMTTKLESEKTHFLPFNMGHDSGAGNPPAEGGRSATAYLWERVWEKDAWLTIIGRLMIVETKEEWDVATGTSVRRTSMLFPRFHQWEAVTKIVAAVREEGVGHRYLIEHSAGSGKTNTIAWTAHRLARLHVNDEKVFDSVIVVVDRNVLDGQLQEAIRQIDGSGKIVATISPVDVRKAGAKSKSGLLATALKNGELIIAVTVQTFRFALDEIRVDTSLKGRRFAVIADEAHSSQSGQMSSKLKAVLTAEEIKEIEEGGEVDVEAILAAEMTERAESENISWFAFTATPKNKTLELFGREGPDGKRVEFHLYSMRQAIEEGYILDVLRGYQSYDTALKIDGRAASGDGKVVEEVTARKGLMRWVKLHPTNISQKVQIIVEHFHINVAHLLEGKAKAMVVTDSRKAAVKYKKAIDAYIAKRAAEDASYNYRTLVAFSNSVKMDEDEEWASDWGPQPSKDEEFTEAKLNPGAGADLAAAFKGTTYKIMLVANKYQTGFDQPLLSALYVDKKLSGVTAVQTLSRLNRTHRTAGGEQKRKTFVIDFVNKPEDIRTAFEPYFTNATLETETDPYIVVHLSNKLAQAGIYTPEQVREVAELWVIRKGNNALSAAISPAKNDFARRYAAAIEAEDKVTLNTLDLFRKDVSTYVRLYDFMSQIVDYGDPYLEMLSIFLRLLEKVIADSSWSAEVDLSDVVLVGVKHTKAAAVDISLTGDGQLKGIGAAGTGTRKEPKYVALQVVIDKMNDLFGAESFSSSQIREFVQGLVERLLAYPDLVNQAKVNSKKQFMESQDFQAAVTEAVIDNQEAHNTMADYFFSDGPGINAVIVALADAFHEAAIDQQTDVWQPGPEMGSRTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF30</accession>
    <name>F4FF30_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clp domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732410.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13140"/>
    <dbReference type="EnsemblBacteria" id="AEB43742">
        <property type="protein sequence ID" value="AEB43742"/>
        <property type="gene ID" value="VAB18032_13140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13140"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090963_2_0_11"/>
    <dbReference type="OMA" id="HIGDEHI"/>
    <dbReference type="OrthoDB" id="1708060at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="21116" checksum="6F8E07CB13A00C11" modified="2011-06-28" version="1">MFERFTDRARTLVRQARDEARAEGQRPVGTEHLLLALLADGDSLAVRVLRDAGVTADDLRARIRRHTETSSTGLAEADAAALREIGIDLAAIVARIEESFGPDALREAVPPPRRRWGRRQRPGGPFSHRAKKVLELSLREAIRLRHRHIGTEHILLGLLREGSGLGALVLAEAGVDLADTRRRVEAALRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF33</accession>
    <name>F4FF33_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase PA-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732413.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13155"/>
    <dbReference type="EnsemblBacteria" id="AEB43745">
        <property type="protein sequence ID" value="AEB43745"/>
        <property type="gene ID" value="VAB18032_13155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13155"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527661_0_0_11"/>
    <dbReference type="OMA" id="PTDFMGA"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="103"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="348"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="496" mass="54074" checksum="431993594B34C84D" modified="2011-06-28" version="1">MGAVKDVLRRPLGHFTERTLAGLALVLGAGVGFGLVLVLVRVQWSPLYDIDHGVAQWLNARVSPIGPLVTVLNAITDLGGRAVIVWLVTVAVVGLLIRRQGRLAVFVIVTGAGALILDPALKTLVDRLRPEVATPIGSYAGQSFPSGHALGSMVAYGALLLVFLPAMAPRWRKPAMVAVGVVVFLIGFTRIALGVHFLSDVIGAWLLGAAWLGVTAYAFRLWRVERGRPAAPLTEGLEPEAAHEVAPAPDEEKLLPHARAGIAEIIVGWVLVFGALYAFGTFVGYHAKGTFLATWDEVVPTWFAARQTPALNDLSWWWSKFGDTHAILLVSMIFCPLVLAIWRRWRPVLFVALTMFGELTLFLASAAAVDRPRPPVENLDGPMPTSSFPSGHIAATLCLWVAIAVIVFPRTDRWWRWLFVVSAVVMPVGVAVSRMYRGMHHPTDFMGAIMLTGLWIGLLYWVLRPNEDVYEGNQPTIESEDVDTLDDELAKAGRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFD1</accession>
    <name>F4FFD1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25675"/>
    <dbReference type="EnsemblBacteria" id="AEB46233">
        <property type="protein sequence ID" value="AEB46233"/>
        <property type="gene ID" value="VAB18032_25675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25675"/>
    <dbReference type="eggNOG" id="ENOG5032YQ8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182353_1_0_11"/>
    <dbReference type="OMA" id="NPKIHTP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="92" mass="10496" checksum="80C650C8CCE36C65" modified="2011-06-28" version="1">MSEPDPSTTTTTLVCSARGCHAPAEWSLRWNNPRLHQPERRKTWLACDAHRGHLGDFLTARGFLREVAPLAESPTLQEWTRTTEGPSREREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFI6</accession>
    <name>F4FFI6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome oxidase assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_25950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734939.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25950"/>
    <dbReference type="EnsemblBacteria" id="AEB46288">
        <property type="protein sequence ID" value="AEB46288"/>
        <property type="gene ID" value="VAB18032_25950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25950"/>
    <dbReference type="eggNOG" id="COG1612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060266_1_0_11"/>
    <dbReference type="OMA" id="LVYAWLM"/>
    <dbReference type="OrthoDB" id="1135592at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="33862" checksum="CB3568CF6F7BA53B" modified="2011-06-28" version="1">MKRPARFPVSSTLLRRLAFANIVANVVIVVTGGAVRLTASGLGCPTWPRCTDDSYTTTAEMGMHGVIEFGNRLLTFVLVLIAGATLLAVLAHRPRRRGALPLALAVVLGIVAQAVIGGITVRTQLHPSIVGIHFVVSMLLLLVSYALWRQVREPDGPKVVLVPPALRALTWITVVVSAAVIVVGVLVTGSGPHAGDADAVRNGLDPQTISQVHADLVFLLIGLTVGLWLALRALGAPAGAVRAVRTLLLVELAQGVIGFVQYFTNLPVLLVGAHMLGSCLVWLATLSVLWSIRERRPAHPDHPATPPASVTPAQEPVTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFJ2</accession>
    <name>F4FFJ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglucose isomerase (PGI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734945.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25980"/>
    <dbReference type="EnsemblBacteria" id="AEB46294">
        <property type="protein sequence ID" value="AEB46294"/>
        <property type="gene ID" value="VAB18032_25980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25980"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036298_0_0_11"/>
    <dbReference type="OMA" id="FGDWAEQ"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="542" mass="55571" checksum="F3066B1CAE557326" modified="2011-06-28" version="1">MGDLLAAPVEAAGGLAVHGARAVDASASASTRQALVDADVPRRLLARDPTLWGPDAVGRLGWLDAHRRGRELLPQLAELTAELADLDHVVLAGPGGPSLAAQVVARTTGRALTVLDTTDPGRVRATLADRLARTVVVLAGSTPEVDCLRRAYRQAFLDSGMTESEVGRHFVVVTDPGSPLAAVAAELGAIIVPADPEVDGGFTALTAYALVPCALAGVAVADLLDQAEAFAATLDSADANPGLALGAALATAATTGRDTVVLVDDGTGVEGLGDWVEQVLAESTGKDGLGLLPVVVESPASPHLTGPDRLTVSYGGALAAGDLPALGVTPDIAVNGPLGAHFLAWQYATALAADVLGVDPFDRPDVSAADEHTAAVLAHRPSASTPSSVEDTIEVYAPAGTPADLTGALRHLLTGLDDRGYLAVTAYLDRHADADAARLRPLLAQLTARPVTFGWGPRHRHATGQYHNGGPRLGSFLQITGTVDVDLPVPGEPYSFGELQAAQAAGDRQALAGHERPLLRLHLTDRSAGLAQLLDAVGSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFM0</accession>
    <name>F4FFM0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Folate-binding protein YgfZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_02065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736131.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02065"/>
    <dbReference type="EnsemblBacteria" id="AEB47497">
        <property type="protein sequence ID" value="AEB47497"/>
        <property type="gene ID" value="VAB18032_02065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02065"/>
    <dbReference type="eggNOG" id="COG0354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_6_0_11"/>
    <dbReference type="OMA" id="RHHELGP"/>
    <dbReference type="OrthoDB" id="1984573at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="32"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="370" mass="39641" checksum="CA1C99C15EE1BECF" modified="2011-06-28" version="1">MIDIAGAVAVESIDESSRDQPEPAHVAAGVRPVAAHYGDPMREQRLLDTEVGLVDRSHRGVIAVPGADRISWLHTLTTQHLAELGPWQGTELLVLSPNGHIEQHAMVAEDGDTTWLDTEPGATEGLLTYLEKMRFFSRVEPRDVTADQALLSLVGPRVAEALALLDVPTLNAPDVSGVPGPKFRSGEVPPRPTARYDVKPLPSGGWARRGPLGVDLLVPRTAMDQVVTRLRDGGVGVAGLWAYEAVRVAARRARVGVDTDHRTIAAEVDLIAPAVHLDKGCYRGQETVARVHNMGRPPRRLVLLHLDGVTTDQLPVAGTPVDLAGRTVGFVGTAVHHHELGQVALAVIKRSVPDDAVLRVGESAAAIDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFM5</accession>
    <name>F4FFM5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dsre family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736136.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02090"/>
    <dbReference type="EnsemblBacteria" id="AEB47502">
        <property type="protein sequence ID" value="AEB47502"/>
        <property type="gene ID" value="VAB18032_02090"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02090"/>
    <dbReference type="eggNOG" id="COG2044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139144_2_1_11"/>
    <dbReference type="OMA" id="ERCSQAF"/>
    <dbReference type="OrthoDB" id="1997912at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="12811" checksum="CACCF891E391487D" modified="2011-06-28" version="1">MLGTMARSLVVKATAGADAPERCAQAFTVAATAAAAGVHVSLWLTGESTWFALPGRAQNFELPHSAPLAELLHVILTTGTVTACTQCAARRDIGTDDVIPGIRIAGAAVFVEETMTEGAQALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFV5</accession>
    <name>F4FFV5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_07055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731208.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07055"/>
    <dbReference type="EnsemblBacteria" id="AEB42535">
        <property type="protein sequence ID" value="AEB42535"/>
        <property type="gene ID" value="VAB18032_07055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07055"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_9_0_11"/>
    <dbReference type="OMA" id="DIMIHET"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="385" mass="42297" checksum="9B2CA97056FC1836" modified="2011-06-28" version="1">MNLHDDPAEAAFRAELRDWLRSRLPDDDPSRTWSTAELRDWSRDLSAAGYAGITWPKEYGGRGLSAAYQAIFVEETARAGAPDHINIIGMNMVGPTLIAHGTDEQKARYLPGILSGRTLFCQGFSEPDAGSDLAAVRTSARRAEPDGYLLDGEKVWSSYAHLADYCLLLARTGPAEPKHQGLTCFLLDMRAPGVKVSPLRQLNGDTDFNQIILTDARVDDGDVVGEVGRGWSVALSTLAHERGTFGITLTARLVAQFDRLLRLVHEVGAEDDPAVRRELAMLHARLQGLRYTGYRSLAALRRSGEPGAESSILKLEWSLLHQRVCALALRLQGPAALLDGGDAAWHGYWQRQRLRSRANTIEGGTSEILRGIVAERVLGLPRSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG15</accession>
    <name>F4FG15_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732427.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13225"/>
    <dbReference type="EnsemblBacteria" id="AEB43759">
        <property type="protein sequence ID" value="AEB43759"/>
        <property type="gene ID" value="VAB18032_13225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13225"/>
    <dbReference type="eggNOG" id="ENOG50342Y9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070789_0_0_11"/>
    <dbReference type="OMA" id="YVHGYAD"/>
    <dbReference type="OrthoDB" id="510345at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="286" mass="29287" checksum="70AF56031789BDFB" modified="2011-06-28" version="1">MAGLWVWERYLGGWLTGACQRARRATLAIVYAGDDARPAEIALRVIGEHGDRLRGCRLSVLVLADGTEDLPARLGAVEAQLPPQVAVHLMPGAPGAPGRLSVALRAAGAAGAPVLSYLGTGGALDPATLAAAATGRPAEVLVLSGAGTSLRPALADAGFPLVTEVELADPAGRIGFGTGSDRNLEALKEAVWATGAALRDPDGVPLRADLPVDVAPLAGVLLAELVRHGPRTVTELRRHAVTDTAYRATDAVRALTGLLDAGQVSRDPEQGRLGGDVLVTAVRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG18</accession>
    <name>F4FG18_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin reductase domain protein fmn-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13240"/>
    <dbReference type="EnsemblBacteria" id="AEB43762">
        <property type="protein sequence ID" value="AEB43762"/>
        <property type="gene ID" value="VAB18032_13240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13240"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_1_1_11"/>
    <dbReference type="OMA" id="CINVLPA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="49"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="21908" checksum="F4D1FDE89F020A0C" modified="2011-06-28" version="1">MQHPAPLRASNTILPRRDTDTGVTTAGRDRVDQLRPVDGDLFDRLRQQQVGTVTVVTAVARNNRSACLGGLGATPRAGFTTTSFTTVSLDPPRVSFSHDTAAPTAPVLDRAEHVAVHLLAANQTEAATVFATPGVDPFAAYPYWEAGPFGLPLLTGVLGRLLCRVVHRIPVGDHTLVVAEPLALSVGVDGDPLLHQPGGYATATPAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG67</accession>
    <name>F4FG67_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732478.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13495"/>
    <dbReference type="EnsemblBacteria" id="AEB43811">
        <property type="protein sequence ID" value="AEB43811"/>
        <property type="gene ID" value="VAB18032_13495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13495"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130332_1_3_11"/>
    <dbReference type="OMA" id="DCRDVIT"/>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="88" mass="9571" checksum="BE68C80F75510E60" modified="2011-06-28" version="1">MQVDENAVDDVIKRLRRAEGQIRGVIGMLEDGRDCAEVVTQLAAVSRALDRAGFKIIASGLQQCVTAAPGEERKANLDQMEKLFLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG84</accession>
    <name>F4FG84_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13580"/>
    <dbReference type="EnsemblBacteria" id="AEB43828">
        <property type="protein sequence ID" value="AEB43828"/>
        <property type="gene ID" value="VAB18032_13580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13580"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_7_11"/>
    <dbReference type="OMA" id="FFDPACE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313019" evidence="1">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="22660" checksum="D41ADCE9E4DC9330" modified="2011-06-28" version="1">MILVVILAMIVVIAVNRNTSRPVASGAPVDPAVLVRDDSHRLSTATDGRVTLVEFLDFECEACGAVYPSITEILDTYQDRITFVVRYFPIASHPNADLAARAAQAAAEQGRFPEMYATLFENQAQWGHQSAPQTDRFVGYARDLGLDVERFRRDLDAAATAQRVAADRADGETAGVRGTPTFFLNGRQLTEVRTQSDMVAAIDAALAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGP3</accession>
    <name>F4FGP3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTPase-like protein probably invoved in signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26400"/>
    <dbReference type="EnsemblBacteria" id="AEB46378">
        <property type="protein sequence ID" value="AEB46378"/>
        <property type="gene ID" value="VAB18032_26400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26400"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255237_0_0_11"/>
    <dbReference type="OMA" id="RTWRSAQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="282"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1252" mass="136447" checksum="0F6D450DF0771977" modified="2011-06-28" version="1">MEPASLTSALAKAIMSQLVRQLAGPALTSVKTRLVGDPERKALEQALDRAFGQTRQAYGHQLADFDVNPDFWQHEGAMELAKVLLPGARPSPAALARRAVESLGTFQSDDEQLDRINLLRPVFKAFLDALSTEVRREPALQALLHRSDEAHSAQATGRLAEQSGAAGAGEDDLLHYLTWLIDQHRYLPTVGVVRNTTVRLPLTEVFVGLQAQVDRRPGDRAWEWFTRERDKLTALMETGQLDQTGFEAALDRLQLTYGRKFPADGERDDTATPVLDTVGRNAQLLVLGDPGSGKTTLLRYLALTYAKARIADSTDPATRLPIYLRIGEYAQHGYPRVGIGEFLVEHLRRHECRTPGLADLLQRHLDTGRCLVLLDGLDEIASAELRRGVVAAVVNFVTAHARQGNRFVVTSRISGYQAAPLPDSFHAVRLTEMDDATIEAFLEVYCREVERAETPERSASATREAAAREAAAIGAALKTTPGVRRLAANPLLLTALVLVHRSSGRLPHRRVEAYIEVCHALGRTWRSAQGVAEADLPDERILNRWLARLGAWLHEHRPEGAASKLELLDVLGPLWAAHHGSPWDPQVLRDADPLDTDPGRGVLDFVRKVDAHTGLLVERAPGRYGFAHLTFEEYYTGRALALLGPIENRASEIRRRLHDPRYDEPILLALGLIGTDYAEQIDEVVAQAIWPAAEPSEYEDLLGRDFLFMLRVLADDVPLTRTATIDEILHQAIEEYLHRDSSRCRFTAYREALVQRLSALGGTRAGERFRAAVDAWVEILDSLAGIPDALEPGRWCELAGIAAAHGQLLPATRNRLVRLATNSSDPYRAIQAMVVLAKQNAWTDAVVAAALALLRSDCGSDVKRFALIALRLADAFTPDVVDAIMEMATSAADPFNRPLAVEMLALRGLLTDELIAAVVGLTTKEQSEDTALALMELAWAGVLTDEVIAALVGLATGADRVDVRVMAAEVLAAGGEPAPEVVAALAELATSAADFEVRVVAVEELARCGRLTGESVTSAMEVATSIGAPESRTRAIKVLADGGRLTDEVVAAAVELATGPGRTAVRVRAMKALTSNETRTDEVTAALVRVATTESENLSERVQAMEVLGEIRALGGEVVAAAVGVATGEHPPDLRARAIWALAAGGMLTGPLAAIAQEIVAEVEDWRIRRALVRHLRYAPPTMELFDTLMARFRDRSAPVWDEVGDTLVEISRRHPEVAADIRSRLAAACTDPLMRSDFVYRALHRQVEAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGV1</accession>
    <name>F4FGV1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736243.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02635"/>
    <dbReference type="EnsemblBacteria" id="AEB47611">
        <property type="protein sequence ID" value="AEB47611"/>
        <property type="gene ID" value="VAB18032_02635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02635"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042432_6_0_11"/>
    <dbReference type="OMA" id="AGEWWRP"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="55"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="245" mass="26119" checksum="89C2EB45E6FE089F" modified="2011-06-28" version="1">MRDAGLSLPRNDPRQYDDLAGEWWRPDGAFAMLHWLAQARAALVPPAARPGALLVDLGCGAGLLAPHLVGKGYRHVGVDLTRSALIQAADHGVTVVNGDATAVPLADGCADVVAAGELLEHVPDWRAAVAQACRLLRPGGLLVLDTLNDTALSRLVAVRIAERLPTVPRGIHDPRLFVDDRELVAECARHGVDLRVRGVRPAVPGLLRWLLRRARGIETPSGQVPRIVPTASAAVLYQGHGVRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH15</accession>
    <name>F4FH15_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731302.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42629">
        <property type="protein sequence ID" value="AEB42629"/>
        <property type="gene ID" value="VAB18032_07545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07545"/>
    <dbReference type="eggNOG" id="ENOG5031GBR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029786_0_0_11"/>
    <dbReference type="OMA" id="WHVYEAR"/>
    <dbReference type="OrthoDB" id="2043824at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="25818" checksum="24243D8EA60EF6AD" modified="2011-06-28" version="1">MGKTPRKVTPAAAVKPKAMIRAMILCIPAELPREALTAHQLDRNFGVRGTLSPRFWASTALHRWQHRQMISLRKGRPASCAGGPAKLLDLDGMLQAAAMGAGIRHQLFSRVVHGTRNAVPWHVYEARHLAAPDTYPWDKAVADFNNQPRVNAIRMHNAATYGAGQIALAEVEMYQAGYMAYQHYSALTAVAGDALITTGGATLAPASAAMADRVTYLEQANRLFAAIDPDQRLLAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH33</accession>
    <name>F4FH33_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42647">
        <property type="protein sequence ID" value="AEB42647"/>
        <property type="gene ID" value="VAB18032_07635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07635"/>
    <dbReference type="eggNOG" id="ENOG5031R81">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2037085_0_0_11"/>
    <dbReference type="OMA" id="MTTHISG"/>
    <dbReference type="OrthoDB" id="2167719at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="121" mass="13301" checksum="1E006D87AD985EC0" modified="2011-06-28" version="1">MLLIGVVGYAVWDRYVREDSGVAACKAMSEGRQPDGSEDAGEDAKLTEAQYREARKVFEDSRHEKIREHGTALMDIVWQVDQMNDDEALGALAFMGPLGTHMTGLQTACADQGVILNLNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH65</accession>
    <name>F4FH65_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_13655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732510.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13655"/>
    <dbReference type="EnsemblBacteria" id="AEB43843">
        <property type="protein sequence ID" value="AEB43843"/>
        <property type="gene ID" value="VAB18032_13655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13655"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_10_1_11"/>
    <dbReference type="OMA" id="GIWMFGG"/>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313942" evidence="2">
        <location>
            <begin position="38"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="60"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="328" mass="34213" checksum="95E0B031F040810D" modified="2011-06-28" version="1">MFRTRVTALVAAAATALLLAACGTTENTAEPAPSASAAGGPVTVTDSRGKEIKLDSPATKVVGLEWGEVEMLVSLGVMPVGVADPKGYATWVTAAKLDPAVKDVGTRGEPSVDSIVALAPDLVVVSDGRGATLLDQLEKYVPVLVTKSSDATDNVGRMRADLNMIAKAVGKTAEAEKLLADFDAALADGKKKIADAGAAGKPFAIADGWKEGSTVSIRMFGQGAFVSQLGIQLGLTNAWNGKVDEVWGLGQTDVEGLTALKSPDLHFFYNASDGTDVFADGLADNAIWKSLPFVKQGNLHRMPDGIWTFGGPLSAKQYIDQFVNTYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHQ9</accession>
    <name>F4FHQ9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ordered locus">VAB18032_26776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735079.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26776"/>
    <dbReference type="EnsemblBacteria" id="AEB46428">
        <property type="protein sequence ID" value="AEB46428"/>
        <property type="gene ID" value="VAB18032_26776"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26776"/>
    <dbReference type="eggNOG" id="COG1799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078499_0_0_11"/>
    <dbReference type="OMA" id="STHANER"/>
    <dbReference type="OrthoDB" id="2064885at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="230" mass="25847" checksum="6AD9EA687CEC137A" modified="2011-06-28" version="1">MGALRKAGVWLGLVEEDDERAYDDGGYDKGGYRESRYRQSRYAEEFADEVDDEVDEPPAPRPRLGDRGRLGERSGGRLSESERLDSERPERVERSSVRSITRSTGEQSGALTYHTRDNLALAPQAQPRERAVVQEEEQRYQITTLHPTTYREARTIGEHFRDGVPVIINLTEMDEADARRLVDFAAGLAFGLRGTIERVTNRVFLLSPANVQVTAEDKAKIAEGGFFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHY9</accession>
    <name>F4FHY9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_02990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02990"/>
    <dbReference type="EnsemblBacteria" id="AEB47682">
        <property type="protein sequence ID" value="AEB47682"/>
        <property type="gene ID" value="VAB18032_02990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02990"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_169_0_11"/>
    <dbReference type="OMA" id="WNLEVLP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="443" mass="47031" checksum="FFB9D48EC72D7B1B" modified="2011-06-28" version="1">MENRTLASERDQARFLREARAAGRMSSHPHVVDLFDVGVTIDQHPYLIMELCDGSYAERMRTSPLDAVEARDLGVKIADAIAHSHGAGVLHRDVKPANILYSHFNSAVLADFGLAVVAEMRDASVALEVLTPAYAPPEMFNHSPPSPAVDVYALCATLYAVMHGRPPRWQAERNPSLVTVLEMFHQPIPSLPGVPEDLMDVLRVGMANDPGERPSAAELRDLLASLSLGAPGRYAQDSSIGFGGGRYAAAGPPHPPPTAAVSGDSGRQRRRRWFFGMAGVAALAASAGVGAWAAGGLPSTQPTLPARPSATGVLRPGCAAVPQALPSGARCAEELECFGPVQVRGQRAEASRVPCDSRHTWESYAQGELPAALVDADHDEIVADPAVRRVCNEETFRLISGGRTTTGWNLEVLPPADAQVDPTYRCLAGRGLDGLASPTLTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI31</accession>
    <name>F4FI31_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_30159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
            <plasmid evidence="3 4">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713117.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30159"/>
    <dbReference type="EnsemblBacteria" id="AEB47995">
        <property type="protein sequence ID" value="AEB47995"/>
        <property type="gene ID" value="VAB18032_30159"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30159"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_425746_0_0_11"/>
    <dbReference type="OMA" id="IRRATWP"/>
    <dbReference type="OrthoDB" id="947135at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="643" mass="68292" checksum="9B90CCD0AFEE3FDD" modified="2011-06-28" version="1">MSTRTVSEVRADRMAAFGRVLTALLAAVAYGVGWLVRRSWRRLLPFYWIAAELAVAWLAGPLGLSWQTVALLTLAIAATAAGWRARSRAVRMWRAAIVVVLGTVAVATVAAGGPAAMAAHPTATIALPTLAGVLLGWPWWYHLRSRPPQDEPVPVPVAVGVPTTVVDPLTDQWSRRWRTEVVDEGVCAGTTLIKATEPRPGVTEALIRLAPKTKPGPLLKSGTDVEVALDLDEGAVGWRSTGKTAWLRVVIVERSYIAAGVPWHGPTYADGRCEIARFTDGSPGHWVFSRPNFGVLGGLVVGSTGSGKTRALGALNANLLEGGFQVVVGDPQNGQSLPAWKDAVEYHAGVEATTLLLRRFHAEVMRRSALLADAGVDTYDENDPRVQALGLGKLMVVVDECQLVLIPNTPLVPLVEQAAETMRKTGAGLVLATQLPQMRSLGGSVRLRDALVAGNALILRLSNRGSGTTILPDDFVGDPFAIEREIDGKSTAGMGYLRHSNRVGMICRVPHLDETAAAAASPRVPVRWNVPPIDPNTPIKAPRTTTTGNSPAAAGGSAGDRLRAAFGIGRKTTTAVVEQSTPQTSAEWVLACLRRGPASAQALLDRPDCPVNQAQLYALLNRLKDSGRIVAPAQRGGPWTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F133</accession>
    <name>F4F133_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_07845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07845"/>
    <dbReference type="EnsemblBacteria" id="AEB42687">
        <property type="protein sequence ID" value="AEB42687"/>
        <property type="gene ID" value="VAB18032_07845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07845"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069543_5_2_11"/>
    <dbReference type="OMA" id="LYWHVKT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="196" mass="21570" checksum="FAA1C61287D25B4F" modified="2011-06-28" version="1">MTLLDEHGIEGLTMRCLAQQLDVTATALYWHVKTKDDVLDLAADHIFGDVPIPDVSDDWLEDIRVLARAWRSAMLRHPWAPRLIGRPMLGPNVLARTEFLQSALVRGGCRGLQLAVATRMLANYVIGASLTEATWHQTADPRTRTAARDHIAANADAYPTLNASGHLDDSRWNDDLLFEEGLDGILLAAARAGTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F135</accession>
    <name>F4F135_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_07855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731362.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07855"/>
    <dbReference type="EnsemblBacteria" id="AEB42689">
        <property type="protein sequence ID" value="AEB42689"/>
        <property type="gene ID" value="VAB18032_07855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07855"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_4_2_11"/>
    <dbReference type="OMA" id="MHTITSE"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307572" description="Carbonic anhydrase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="235" mass="25085" checksum="9897690BC47EF0B3" modified="2011-06-28" version="1">MNPSPLSRRSLLATGGAVVVAATATAAARPAVAAETKRPPVTPDEALRRLLHGNHRFVTGHSRHPHQSLNDLRRLAAGQHPFAILLGCADSRVTPELLFDQGLGDLFDNRVAGNIVDDLVLGSVEFAVEEFHSPLIVVLGHERCGAITATIDAIRSGGTAPGHIGTIVDSLRPIVQPVLGQPGDPVDNSVRANVRAQVRNMIERSPIIAERVHERALRVVGARYDLDTGHVTLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1G8</accession>
    <name>F4F1G8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase fkbm family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733851.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20485"/>
    <dbReference type="EnsemblBacteria" id="AEB45197">
        <property type="protein sequence ID" value="AEB45197"/>
        <property type="gene ID" value="VAB18032_20485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20485"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095342_0_0_11"/>
    <dbReference type="OMA" id="CARSIRA"/>
    <dbReference type="OrthoDB" id="1340956at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="53"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="27433" checksum="93D3513D4DADFF25" modified="2011-06-28" version="1">MSFQSAAVEALKADPATAALHRSLEVYYGDPERDAAMDAFYARFVRPGDLVFDIGSHVGDHIGSFRRLGARVIAVEPQPLCLRALRAIYADDDQVTLVAAACGAQPGRIGFLVNSANPTVSTASGDFVAAAAGAGGWEDQVWDGQIEVPVTTVDALIAEHGTPTFTKIDVEGFEDAVLAGLSRPLPALSFEFTTIGRSVALRCLDRLAALGFGGFDVALGDTKALTLGRWVDAAEMATHLLALPHETNSGDVYCVPSTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1M5</accession>
    <name>F4F1M5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvP</name>
        <name evidence="9" type="ordered locus">VAB18032_20770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733908.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20770"/>
    <dbReference type="EnsemblBacteria" id="AEB45254">
        <property type="protein sequence ID" value="AEB45254"/>
        <property type="gene ID" value="VAB18032_20770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20770"/>
    <dbReference type="eggNOG" id="COG0403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_11"/>
    <dbReference type="OMA" id="CVPMSEY"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="940" mass="99580" checksum="E33198B36A5119D6" modified="2011-06-28" version="1">MTAELFADRHIGPGPDDERRMLETVGYASIDELMDAAIPEVIRWHGRLDLPEPASEHDALAELRALAAENTVAVSMIGLGYHGTHTPAVIRRNVLENPAWYTAYTPYQPEISQGRLEALLNFQTMVSDLTGLATANASMLDEGTAAAEAMTLARRASKSSSPVYVVDADTLPQTLAVITGRAQPLGIEVRVVDVDRDELPAEFFGLHLQYPGASGTVRDHARLVEAAHAVGALVTVAADLLALTLLRPPGEIGVDIAAGTTQRFGVPMGFGGPHAGYLAVRRGLERMLPGRLVGVSRDTAGQAAYRLALQTREQHIRREKATSNICTAQVLLAVMASMYAVYHGPDGLRRIARRTHASAARLAAGLRAGGVDVADVPFFDTVTATVPGRAVEVVAAAAARNVNLRLVDADRVGISCDETTTGAHLAAVWAAFGVDGVDGDTDVALPGALARTSDFLTHPVFRSHHSETAMLRYLRRLADLDYALDRGMIPLGSCTMKLNATTEMEPISWAQFAHLHPFAPAEQTTGYRTMISQLEGWLAEVTGYDAVSVQPNAGSQGELAGLLAIRAYHRSRGEGHRTVCLIPSSAHGTNAASAVMAGMRVVVVGCDADGNVDLVDLDAKIEAHADTLAAIMVTYPSTHGVYETGIAQLCAKVHDAGGQVYVDGANLNALVGFAKPGRFGADVSHLNLHKTFCIPHGGGGPGVGPVAVRAHLAPFLPGDPVGEPVDGRPAISAARYGSAGILPIPWVYLRMMGAHGLARATGVAVLAANYVAARLRGHFPVLYAGNKGLVAHECILDLRPLTKATGVSVDDVAKRLIDYGFHAPTMSFPVAGTLMVEPTESEDLAELDRFCDAMIAIRAEIDAVAAGQWPADDNPLVNAPHTAAMVSGDQWPHAYPRSVGGYPAGVDRVAKYWPPVRRVDGGYGDRNLVCSCPAPQAYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1W6</accession>
    <name>F4F1W6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736345.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03145"/>
    <dbReference type="EnsemblBacteria" id="AEB47713">
        <property type="protein sequence ID" value="AEB47713"/>
        <property type="gene ID" value="VAB18032_03145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03145"/>
    <dbReference type="HOGENOM" id="CLU_2653482_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="76" mass="8949" checksum="AD246EFA19C4ACA4" modified="2011-06-28" version="1">MRRPRLRQVLLGLGFLLWLVAGLDLWFDWLGWLTPPLLLVAGALVHGPDVVRAWRERTSKPPEPAERVLRHYPTWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F215</accession>
    <name>F4F215_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_03390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03390"/>
    <dbReference type="EnsemblBacteria" id="AEB47762">
        <property type="protein sequence ID" value="AEB47762"/>
        <property type="gene ID" value="VAB18032_03390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03390"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_2_11"/>
    <dbReference type="OMA" id="TSPLWGM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="159"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="34573" checksum="B0D9606AD34721B9" modified="2011-06-28" version="1">MDLTPDKLALRSWLPGFVALAAIWGSSFLFIKVGVAELHPLHLTLYRVGAGALTLLVVLALLRDRLPRDPRVWGHLCVIAAFGVAVPFSLFGYGEQRIESLLAGIWNATTPLVVLPMAVLVFRTERLTVRKAVGLALGFAGVLVVLGVWQGVGGAHLVGQLMCFAAAACYGLAIPYQKKFVAGSELSGLSLSTAQLVLATAQLAIVAPLVAGAPPVPTSLSPSVVASVLVLGAIGTGLAFVINLRNIRIVGATTAAMVTYLIPVFAIVIGALVLDERLTWHQPVGALIVLLGVAVSQGLIGRRRAGTARPSDPVRAGTTPAGVPSAVSAEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F259</accession>
    <name>F4F259_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08150"/>
    <dbReference type="EnsemblBacteria" id="AEB42748">
        <property type="protein sequence ID" value="AEB42748"/>
        <property type="gene ID" value="VAB18032_08150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08150"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_11"/>
    <dbReference type="OMA" id="NRPVVGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="280" mass="30389" checksum="6C2854DF9D7C341E" modified="2011-06-28" version="1">MTGVNGSLRDTDRRLVVVTGASAGIGLAAAVELARRGDQVVLVGRDPSRLRTAADEVRESSGERPAVFRADFAVLDDVRQLAEQLRAAYDRIDVLANNAGAIVLAPVTTVDGFELSVQANHLAPFLLTNLLADRVRRMVVTASGAHRSGVLDPDDLNAPLRRYRPLTAYGTSKQANILFTAEAARRWPQIGSYCFHPGVVRTRFGNESRLVAVGMRLLPLRSPGKGAQTLVWLANQDRSRLRDGGYYFDCRPRRPLRKAADPQLAARLWTASAAAVGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2I5</accession>
    <name>F4F2I5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="11" type="ordered locus">VAB18032_14725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14725"/>
    <dbReference type="EnsemblBacteria" id="AEB44057">
        <property type="protein sequence ID" value="AEB44057"/>
        <property type="gene ID" value="VAB18032_14725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14725"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_4_2_11"/>
    <dbReference type="OMA" id="WPRARRT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB44057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="614" mass="64215" checksum="5BEF5B979D87EA90" modified="2011-06-28" version="1">MAVLGGILVVLYLLVFFAGGASGGWKDRLEPRLGLDLVGGTRLTLEATNTLDGRAPTADNLEQARQIIESRVNAYGVAEAEVVTEGDRNIVVSLPGENRDLTEIGSAAELRFRKVLKIVDGSGAIPSPAPSPSGTADPAATPSPTGSATPTPNAEATASPSGGQGGGAPSESPSATPSPSASASPSASEEPVPQSLEDQRKAVEAKVGAEAWAAASGLQAPADFSADPTLAEKLKPFAELTGREVAVLPTQMQFNVPTIGCLQLDDRPPASISAADQQVVACEGGYAKNLLDQAKVLGTDVDSAAAVRDQTSQWVVSLDFTRNGQEKWTALTREAFNNEGQACDASALGDEGRCRVAVVLDNQIISSPQIQGVLTGNSQITGNFSNAEASELAGYLNYGALPVTFEAQEQQNVTATLGASYLRAGLLAAGIGMLLVIIYSFFYYRLLGTVIFASLVLSALLLFGALVVLGRQIGFTLTLAGISGIIVSLGVAADSFVIYFERLKDEIREGRSPRSAVSRAWVRARRTIISANAITIMSAVVLYIVSVGTVKGFAFALGLATVLDLVVVFLFRHPMMTMLARSQAFLSPRVSGLGRVLPAKSEQAQPRNPRVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2M0</accession>
    <name>F4F2M0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20925"/>
    <dbReference type="EnsemblBacteria" id="AEB45285">
        <property type="protein sequence ID" value="AEB45285"/>
        <property type="gene ID" value="VAB18032_20925"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20925"/>
    <dbReference type="eggNOG" id="ENOG5033A88">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084427_1_1_11"/>
    <dbReference type="OMA" id="GPVMHLD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="219" mass="24291" checksum="DA4CD1D661FDB2BE" modified="2011-06-28" version="1">MITPHPHDFYREVARVALTVAGPYRFVLGGGVAWAAHGLVTRPTEDVDLFADVEGAAAAAAADVRDALRAAGFEVTDADPDSDLGDLFDGFHADMRDFVVARDGRRIRLSLARLDRHRSPVVMDFGPVMDVRDLIANKTAALVNRREVRDYIDVAAALADRSVAELLELARQLDPALDDEDVRAAGRYLDRIPDRRFARYGLDTADITRVRRQLATWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2M4</accession>
    <name>F4F2M4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily mfs_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_20945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20945"/>
    <dbReference type="EnsemblBacteria" id="AEB45289">
        <property type="protein sequence ID" value="AEB45289"/>
        <property type="gene ID" value="VAB18032_20945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20945"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OMA" id="QNIGSAF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="476" mass="49648" checksum="6A673DCA8B4784D7" modified="2011-06-28" version="1">MTDAARAAPESYDGRRRWQALGVGLVAAFMTLLDISIVNVAIPSLDRGLDASPADLQWVLSGYALAFGLVLVPAGRFGDVHGRRNAFVFGIALFTATSAVAGLAQSATWLVLARLLQGAAAGLVNPQVTGMIQQLFQGPERARPFGLLGATIGISTAIGPLLGGVLIAAGGPEHGWRWVFFVNVPVGIVAMVLGWRLIPHRPVGQTVRRRADPVGVLLLGVGVTLLLLPMVQREQWHGPAKWLLLPAGLITLVGFTFWERRYARRGPPLFDVGLFRVQSYALGALIALSYFGGFTAIFFIFTLYLQTGLGYSALVAGLAITPFALGSAVASAIGGRIVNRFGRPLVAAGLLAVVVGLGLVALAIEVAPHAPVPWVTAAPLLLAGIGSGLVIAPNQTLTLSEVPVPQAGSGAGMLQTGQRIGSAAGIAAVGAVFFSAVGSDNDWSKAFEQSLLVSAGIIALALLVALVDIFRHRRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2N7</accession>
    <name>F4F2N7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733956.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21010"/>
    <dbReference type="EnsemblBacteria" id="AEB45302">
        <property type="protein sequence ID" value="AEB45302"/>
        <property type="gene ID" value="VAB18032_21010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21010"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_6_0_11"/>
    <dbReference type="OMA" id="DYGHDLI"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="295" mass="31429" checksum="060F3AF5B283CBAB" modified="2011-06-28" version="1">MSDYGHDLIFGSFLTPGSADATQPVRLAMLSEQVGLDLVTFQDHPYQPAYLDTWTLMSFVAARTSRVRLAANVTNLPLRPPAVLARSIASLDLLSGGRTELGLGAGGFWDAIESMGGRRLSPGQAVRALEEAIEIIRQVWDAGARGGVRVDGEFHRVIGAKRGPAPAHDVPVWIGAYKPRMQALTGRLADGWLPSLPYLQPGDLAKGNAVIDEAATAAGRSPTDVRRLLNISGRFTATGSGPLQGPAEQWAEELADLALTEGVSAFILASDDPDDLRRFAAEVAPATRELVAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2T9</accession>
    <name>F4F2T9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735200.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27386"/>
    <dbReference type="EnsemblBacteria" id="AEB46550">
        <property type="protein sequence ID" value="AEB46550"/>
        <property type="gene ID" value="VAB18032_27386"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27386"/>
    <dbReference type="eggNOG" id="ENOG50331DK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129731_0_0_11"/>
    <dbReference type="OMA" id="KTGYPQR"/>
    <dbReference type="OrthoDB" id="1937643at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="109" mass="13027" checksum="9EB59FFF21654553" modified="2011-06-28" version="1">MGLFRRRKRARAAEPDRTANRADLEHLENFVRTRKGVEAYIEPRTTVTETTVILIADDGEWTRRRINGPDGARRFAYRLSIPIYDVALMGYPQRMRDYNERRKRRPELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Y1</accession>
    <name>F4F2Y1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27596"/>
    <dbReference type="EnsemblBacteria" id="AEB46592">
        <property type="protein sequence ID" value="AEB46592"/>
        <property type="gene ID" value="VAB18032_27596"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27596"/>
    <dbReference type="eggNOG" id="ENOG5031TGP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2095860_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="116" mass="13197" checksum="9DE8419D73F756E5" modified="2011-06-28" version="1">MSALRSCVQLYRPIGFQTTLSFLDELAGPFHREEAALLRALDALSMSRDQRRTEFRRYAAARRAAKRRGHRSPHPELANDPGSLITTVQVHHAPDELLKARIETIMSMLARYQVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F341</accession>
    <name>F4F341_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_03690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736452.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03690"/>
    <dbReference type="EnsemblBacteria" id="AEB47820">
        <property type="protein sequence ID" value="AEB47820"/>
        <property type="gene ID" value="VAB18032_03690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03690"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="DMMFLIG"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="22485" checksum="83C4916E87F4D365" modified="2011-06-28" version="1">MSHCSPIRVAVVDGQPIFARGLELLLPAATDGRAQVVGFTADAAAAASLVRRCVPDLALVDLHMPAPGGIRAVAAIRRTTPQVRIVAMSDAEDLSSPLQALEAGAEAYMPKSAEPEKLLPPLLAVLDGWAVMPTQLLSTLLRPARFPPVSLDEAERALLRSIAAGRSTLEIADQMHVSDRTVKRMSAALLRKLRVSNRAQAAALAGHAGLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3C5</accession>
    <name>F4F3C5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_08655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731520.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08655"/>
    <dbReference type="EnsemblBacteria" id="AEB42849">
        <property type="protein sequence ID" value="AEB42849"/>
        <property type="gene ID" value="VAB18032_08655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08655"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002554_0_1_11"/>
    <dbReference type="OMA" id="EFARPDF"/>
    <dbReference type="OrthoDB" id="811938at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="557"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="693"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="758"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="852"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="971"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1114"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1150" mass="121273" checksum="4F456A47159C8B68" modified="2011-06-28" version="1">MSKRPKTAGSFLSRLRRPVGRLRDMPIWSKLGLIMIVPTIATVVVGTSGLFDHLDSLNDANRAGDLAELIGYSGELVDGLQDERTAAVLLLGVPPQQAGQPEPEAKKKYSALYNEVAKRVDDDKGPYSQQRSELTDLPVSLAGLLDQIDGRLADLPGTRSQVFNGKFKITDALQSYDELINQLLTIRDSASQLAGDNELSDRMRAAAAVAREKEWLSVRRVVVHRALQRGMSSALRTDYIASETGQQQAQQSFTSVATEEEAEFHAQTIGGGDRRQATIYISQVNADTSADLSGVSFNADQWDAALVANGKLIRTVEAKFDADVQDQAAELRSDVQRQVFLETGLLLTMLLLAVILAYLVARSMARSLRELRQGALSIAQYGLPQAVARLRDPQVTGQLSPVQLANQIAEPLPVRSRDEFGQVTEAFNAVHLEAVRTAAEQAALRASVATMFVNLARRSQILVDRLIGHLDRLERGEEDPDRLAELFQLDHLATRMRRNDENLLVLAGADSTRVQREPAALIDVLRAAQSEVEHYTRIEFGVIDRDIEVAAHAVNDLVHLVAELFDNATAFSPPDSQVLVEARRVGDRASLYVEDRGIGISPEQLTDLNERLATPPQVDVAVSRMMGLVVVARLASRHAVKVELRPGTDRGTVADVTLPPTVLVPRALSGRGPHPAALPAPAAPLPGPSPAFGALPALGNGPSAPAAPAAPSVPTQRSGGSGNQVTLGGRPFEPANRNGSGTPAGAGNLPAWSDLTGASGVTGGNSFTPRPTGGQSTDPLPQRRVADEQTGGQPSVPRQLSSSPEVAPYAPPAVSAPPIPPVSSPPVSGTPYSAPPVSAAPVSGQPVSAAPISTPPGSPLPQRPVSAGPAGPATPAPPAWPPVAAEQAAPAVPERLAAALDMTTELPRVPRPAAQPTRPAQPTVPTPAQAQNRQRYADETMELPIFRELESAWFRTRRPGPEESAGARQPAANGAPTQQFSSVDPVGRPSTQNQTGTTGNAPMAETPTAAGGNGAAANGGPRPGSAESRPTYRPPSPESVWQTAADDGWRAASAASQAPPAGTTQTGLPKRTPMAQLVPGAVEKPTNSVQRRNPESVRGLLSAYHRGVQRGRSHPSDGNPTGPEGTPGGQQSSQSGSGPVAGSRQKEQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Y8</accession>
    <name>F4F3Y8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_27806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735284.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27806"/>
    <dbReference type="EnsemblBacteria" id="AEB46634">
        <property type="protein sequence ID" value="AEB46634"/>
        <property type="gene ID" value="VAB18032_27806"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27806"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_11"/>
    <dbReference type="OMA" id="DAMNMAP"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313573" evidence="4">
        <location>
            <begin position="33"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="5">
        <location>
            <begin position="109"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="582" mass="58793" checksum="0EE757E6A9E8EBB8" modified="2011-06-28" version="1">MGRVSTTPRRVAAVLVAVTMLLASGCSQPGQRPGSAPASGSTSPSTPAAPDPSPTATPDDPATRAAALVAELGDEDLVGQVLMPYAYGDRATQVSAGSAAGNRALAGVDTPAEMIEKYRLGGLILVGFSADDPTQGNQPTTNVDNPKQVRELTTGLREAAGKLAAGAAPLLIGTDQEYGVVTRVTEGVTLLPSALAAGAAADPALTEAAWRAAGTELAAMGINVDFAPVADVLVTRSAVIGSRSFGADPQRAGQQVGGAVRGLQAAGVAATVKHFPGHGHSADDSHQDLPVLSQSRKKLAAQAWPPFTAGIEAGALAVMSAHLDVRSVDPGVPATFSYKLLTEVLRGELGFQGVVVTDGMNMAPARRWGPGEAAVRALKAGNDLILMPPNVSQAYDGLLAALRDGSLPRARLVEAATRVLTMKFSLAGAPTPELSALATPAHRAAARALAAAAVTVLRGRCDEVAIRGPVTVTSSDGRAHTRTALTEALTEAGVRVVPSGGTIVHLVGYGDRAGDLRADAAVTVAMDTPYVLGQAKSPTLLATYSSSRASMEALADVLAGKATAPGRSPVPVSGLSATTCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4A2</accession>
    <name>F4F4A2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ordered locus">VAB18032_04165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04165"/>
    <dbReference type="EnsemblBacteria" id="AEB47915">
        <property type="protein sequence ID" value="AEB47915"/>
        <property type="gene ID" value="VAB18032_04165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04165"/>
    <dbReference type="eggNOG" id="COG1526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056887_3_0_11"/>
    <dbReference type="OMA" id="RAFWNLK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="29029" checksum="A8C1DE89745D9878" modified="2011-06-28" version="1">MVLRVDLDATADGRTLTRRPDTLAAEEPLEIRVGAAGPGRRRPLSVTMRTPGADLDLALGFLFAEGLIRSADDVSTAQLCAGAETPNTYNVVDVALAPGVPEPAAEASRQFTTTSACGVCGKESIEAVRTRSMFDVAGDPLTVPAELLAELPQRLRAGQRGFDRTGGLHAAGLFTADGDLVVLREDVGRHNAVDKVIGWAVRERRLPLAGYVLLVSGRASFELTQKAWMAGLPLLAAVSAPSTLAVDLAAEAGMTLVGFLRGRTMNVYTGAHRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4B9</accession>
    <name>F4F4B9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_04250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736564.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04250"/>
    <dbReference type="EnsemblBacteria" id="AEB47932">
        <property type="protein sequence ID" value="AEB47932"/>
        <property type="gene ID" value="VAB18032_04250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04250"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_1_2_11"/>
    <dbReference type="OMA" id="VDHVHPT"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="169"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="402" mass="41226" checksum="E3CDD90343DB0D17" modified="2011-06-28" version="1">MGWEQARSRAYAVGLAAALPTVDVLLADADGHTLAEPLAPRTDLPAFTTSSVDGWAVRGPGPWRIVGRVLAGTTPAPLTEDGTTVEIATGAMVPPGASAVLRVEESTRTPEGFVDGVPRPAPEWRLPGEEAAAGEELLPVGTPVDPSVIGLAASCGHDTLRVRAQPRAALLVFGDELLTAGPPADGRIRDALGPAVPGWLRRYGCQVRTTDVVGPVADTLPAHEAALRSALVEVDLVCTTGGTMRGPVDHLHPALAALGADYVVNTVAVRPGFPMLLARVIGPDGRSRFVAGLPGNPQSAVIALVSLVAPLLAGLAGRPMPVLPHAMLAEPIPGRGNHTHLALVRLDRVAGTAHPVRHVGSAMLRGLSGADGFAVIAPGSSGAAGDRVPVVPLPLLPGERTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4E8</accession>
    <name>F4F4E8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731577.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08940"/>
    <dbReference type="EnsemblBacteria" id="AEB42906">
        <property type="protein sequence ID" value="AEB42906"/>
        <property type="gene ID" value="VAB18032_08940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08940"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_11"/>
    <dbReference type="OMA" id="YAYAECT"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="277"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="527" mass="56978" checksum="93715DCA936BB834" modified="2011-06-28" version="1">MTTETGSNLHSTAGKLADLARRVDEAVHAGSTRAVEKQHARGKKTARERIDLLLDEGSFVELDEFARHRSTNFGLDRTRPYGDGVITGYGTIDGRQVCVFAQDFTVFGGSLGEVFGEKIVKVMDLAMKIGCPVIGINDSGGARIQEGVVSLGLYGEIFFRNVRASGVIPQISLIMGPCAGGAVYSPAVTDFTVMVDQTSHMFITGPDVIKTVTGEDVGMEELGGARTHNSRSGNAHYLATDEDDAIDYVKALLSHLPSNNLDEPPVFPVDADLAVTDADRELDTLIPDSANQPYDMHRVLEHVLDDGEFLEVQPLYAQNMVVGFGRVEGRPVGVVANQPMHFAGTLDIAASEKAARFVRTCDAFNIPVLTFVDVPGFLPGTGQEWDGIIRRGAKLIYAYAEATVPKVTVITRKAYGGAYDVMGSKHLGADLNFAWPTAQIAVMGAQGAVNILYRQELAAAEDPAAVRAEKIAEYEDTLANPYVAAERGYVDAVIPPHETRTQIVRALRVLRTKRETLPPKKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4G2</accession>
    <name>F4F4G2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731591.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09010"/>
    <dbReference type="EnsemblBacteria" id="AEB42920">
        <property type="protein sequence ID" value="AEB42920"/>
        <property type="gene ID" value="VAB18032_09010"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09010"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059319_2_0_11"/>
    <dbReference type="OMA" id="KWGLSYM"/>
    <dbReference type="OrthoDB" id="1611492at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="225" mass="24548" checksum="F24727EED5472CC5" modified="2011-06-28" version="1">MSRLWSRFAARGVAVVLLSGGVAGGFYLSDDRQTPRPDPGAQVAGSVTQIDVDYRQEQQVSRQVRAARQQAVETRKRARAAAEKARKAEEAARKKAAEEKAAKEAAARARALKPYDGPIPASCAEYSGNRKTGCALMIDAGFKIDQFPCLDKLWTKESGWNPRAHNNSSGAHGIPQARPGNKMATVGSDWETNPVTQIKWGLGYIKGRYGTPCSAWNHSQNTGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4L2</accession>
    <name>F4F4L2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
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            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:transferase activity"/>
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        <property type="entry name" value="Glyco_trans_2-like"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
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        <property type="entry name" value="Glycos_transf_2"/>
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    </dbReference>
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        <property type="entry name" value="SSF53448"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="28859" checksum="EA781580841A9F0D" modified="2011-06-28" version="1">MIPRVSVIVPVYNEGAAIVRCLERMLREMLLPAEVLIVHDMPEDTTVPYVVQAARTDPRVRAVLNTYGRGPANAIRFGIDVARAPVVVVTMADGCDDPRQIDELARLVDRGVVVAAASRYMPGGQQVGGPRLKRLMSRWAGRSLYTLARVGTRDATNSFKAYDTAFVREVGIESRTGFEIGLELTAKATRLRLPVAEIPTIWLDRPLGESHFDLGRFLPGYLRWYLFAYGRRLSREKLAARTRPAAVQSVESTEYEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
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        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB44181">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="34739" checksum="163923A42502F957" modified="2011-06-28" version="1">MATGQLIDEDPEQALAHALAARRLASRISAVREAVGLAAYHAGEWQTAIAELRTYHRMSGLQSHLAVIADCERALGRPERAIDLFRGADQEKLDRAVAIELLIVAAGARGDLGQRDAAVAMLQVRELTSDTAEPWTARLRYAYADALLAVGRRAEAREWFSRAAEVDADAETDAAERLLELDGVLIEGDEEDEAAEELVAGPGAPGAVEAQPDTDVSGAAVAFAERAGDDDDDDDDDDEDEDEDEDEDGATEDVTVAVALEGEPGDAVNAGDAVEDSPVVEGDAVEDVAGEAADEERDADAVVPPTVTPVDGADRSEQGGSPESETQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Q0</accession>
    <name>F4F4Q0_MICM1</name>
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        <submittedName>
            <fullName evidence="9">Virulence factor mvin family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ordered locus">VAB18032_15400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15400"/>
    <dbReference type="EnsemblBacteria" id="AEB44192">
        <property type="protein sequence ID" value="AEB44192"/>
        <property type="gene ID" value="VAB18032_15400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15400"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_2_0_11"/>
    <dbReference type="OMA" id="WLYFANR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB44192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="564" mass="57268" checksum="677BF51C63A11C0A" modified="2011-06-28" version="1">MTSTRWAAAPTDVTRPAPLAGAGRVASAAALIAVLTVLSRVAGFGRTAVFTWVVQDSDLGAMYVLANTAPNIIFEIVAGGALASLVVPLLAGAVAAGDRRAVAATTGALLTWTVTLLVPLAVLLALGAGPLINLLGDSRSPEELAAGARMLRVFAPQLPLYGIGIVLSGVLQAHRRFAWPVIAPLLSSLTVIVVYLVFVGVAGPGASVAQAGRGAELILSAGTTLGVAVLSLSLLIPIRRLRLRPRFGYTFTADARARVGGLAVAGVVTVTAQQVALAVILYRVAGGLTEAPQVFNLAQTFYLLPWAVLSVPLATAAYPTLAAASAGGDEQTYRRTLAATLRGVLLLSFLGAAVLVGTAGPIGRFFPLNADATAHAIAGYAPGLLGYGLFAVLSRALYARGATRSATAAITAGWLVVPLALLPLSTLLPVADRVLAAALANSVGMLLLGGLLLLAVRRAAGPVALAGAGRAAGAGLLGATAGTLAALGLLRLLADADGTPTRWVALGQGMLSGALVGVVFLAVVWLVDRRDVRPVLAGLRRRLPARVRGRQADGNRPEQADGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4V4</accession>
    <name>F4F4V4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21715"/>
    <dbReference type="EnsemblBacteria" id="AEB45443">
        <property type="protein sequence ID" value="AEB45443"/>
        <property type="gene ID" value="VAB18032_21715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21715"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010262_0_0_11"/>
    <dbReference type="OMA" id="WREYPTD"/>
    <dbReference type="OrthoDB" id="1388830at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="739" mass="78978" checksum="5E35D032AB9CBB4C" modified="2011-06-28" version="1">MTVSSTYHFLPWAREGLANRLRAPGPREDPRRGHVTVTATLNEESLGDIAVATLGPGDVTGLAPHQILRTDPPPDTLGFEPDHYPTLDLDSPTLPWLFTPLPPTGDRLPPWLCLVAVRQQPGVRLRTDGVRNTTVLEIRAPADARRELPDLTHSWAWAHVQLVGALATGESAAQVLRQAPERTVSRLICPTPLRPDARYHACLVPTFAIGRAAGLNLPLPEGTGPAWHATDQEVTLPVYHHWEFSTGTGHSFADLVRALRFRSAPEGVGRRPFDLAGSGLTAPTGAAPLPPFDGALVRLGSGHTAPPDWVRQALAPLVGTGSGSAAPLYGGEHLDRRTVSVGDTGWLAELNLDPRYRGVAGLAAAVVRERQEDLVAAAWQQAGDVGPVNRLLATSDVANTVNGSLHARRLTGLPADGLTLTQLAAPLGRTAGAAVVTTTAYRRVSRRRGPIARRVAAPAPVTVAPADVAALTRALEPARTVKQRVDSRLNGATGADQPDRIRVAPTFPTPMVGELARLAPQFLLPGADRIPPESVVALETNPRFVAAFLAGLTTELASELRWRDFPLAERATLFRHFWDQRGQGGDGTADVPPIDKWPADRRLDQVVTGDAARLVLAVRGELLRRHPRTAVYAVRAASRTAPADEAGTGNVAYPIFGGTLGADLRYFGFDLTEEQATGLTDPPGWFFVFAEQPTETRFGPPPTGDPLAGAGVTAAEVARRTLRLPLRVLIHAADLLTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F545</accession>
    <name>F4F545_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_28281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735377.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28281"/>
    <dbReference type="EnsemblBacteria" id="AEB46727">
        <property type="protein sequence ID" value="AEB46727"/>
        <property type="gene ID" value="VAB18032_28281"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28281"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_11"/>
    <dbReference type="OMA" id="CHCVSGP"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="252"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="287"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="523" mass="55421" checksum="727B410B27594432" modified="2011-06-28" version="1">MGGVRLRGFGWRHAGRRAWAVRGVDLWVRRGERVLLLGPSGAGKSTVLAALAGLLPEDSGEQEGIIEIDGRPPAEVRERVGIVFQDPQSQLVMARSGDDVAFGLENRGVPAAQIWPRVDEALQRVGFPYHRDRRTAALSGGEQQRLALAGALALRPDLLLLDEPTANLDPAGADLVRAAIARAVDGDTTLILVEHRIADALPLVDRVVVLEAGGGVRADGTPEAVFAAHGDALAADGVWVPGRQFPPRPAIAPAGEVLLTADRLGQPPRLAPTNLTVRAGEALAVLGPNGAGKSTLALLLGGLLKPGTGRLSGSTELAGADARTAPHRWRAPALARRIGSVFQDPEHQFVTSTVFDELALGPRRTGATDAVVRQRVDDLLQRLRLDKLAGANPYTLSGGEARRLSVATALATAPRLVICDEPTFGQDRRTWRELVDLFAELRDAGHGLVTVTHDTDFVAALADRTLTLRPVPRRGDDPSDRPDLPTREPGDGRPVDRGRPAGSEGGMRMSPTDDAGPATAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F4F553</accession>
    <name>F4F553_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">era</name>
        <name evidence="12" type="ordered locus">VAB18032_28321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735385.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28321"/>
    <dbReference type="EnsemblBacteria" id="AEB46735">
        <property type="protein sequence ID" value="AEB46735"/>
        <property type="gene ID" value="VAB18032_28321"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28321"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_0_2_11"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="209"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="45"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="66"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB46735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="299" mass="33032" checksum="6396840E6A41EF71" modified="2011-06-28" version="1">MSAAPTPRAYRAGFACFVGRPNAGKSTLTNAIVGQKIAITSNKPQTTRHIIRAVLHRPDSQLVLVDTPGLHRPRTLLGERLNDLVRQTWSEVDVIGLCIPADEPIGRGDRFITGELAELKATVLAVVTKTDLVDKKRLAEQLLAVSELGEFAEVVPVSAVAGHQVDTLVEVMTRYLPESPQLYPDDMLTDDPEQVLVAELVREAALEGVRDELPHSIAVVVEEMIPEGQLTKIYADLYVERPSQKAIVIGHRGSRLKAVGTAARRQIEELLGTRVYLDLHVRVAKDWQRDPKQLRKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5D1</accession>
    <name>F4F5D1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">recF</name>
        <name evidence="10" type="ordered locus">VAB18032_04485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736610.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04485"/>
    <dbReference type="EnsemblBacteria" id="AEB47979">
        <property type="protein sequence ID" value="AEB47979"/>
        <property type="gene ID" value="VAB18032_04485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04485"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_1_1_11"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="377" mass="40764" checksum="D6B2FFFC0C86D0D2" modified="2011-06-28" version="1">MYVRRLELVDFRSYERVGVDLEPGPNILIGANGVGKTNLVEALGYVATLDSHRVATDAPLVRMGATAAVIRCAVVHEGRELLVELEIVPGKANRARLGRSPARRARDVLGALRLVLFAPEDLELVRGDPAERRRYLDDLLVLRQPRYAGVRADYDRVVKQRNALLRTAYLARKTGGTRGGDLSTLAVWDTHLARHGAELLAGRLELVAALTPHVAKAYDAVAAGRGAAAIAYRPSVELTEPTTDRETLAKVLAAALEEQRSAEIERGTTLVGPHRDDLTLNLGPLPAKGYASHGESWSYALALRLAGYDLLRNDGIEPVLVLDDVFAELDAGRRDRLADLVGGASQLLVTCAVADDVPDALRGARYEVSEGTVRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5F9</accession>
    <name>F4F5F9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="2">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mca</name>
        <name evidence="3" type="ordered locus">VAB18032_09365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09365"/>
    <dbReference type="EnsemblBacteria" id="AEB42991">
        <property type="protein sequence ID" value="AEB42991"/>
        <property type="gene ID" value="VAB18032_09365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09365"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_2_2_11"/>
    <dbReference type="OMA" id="PLKLYYN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="286" mass="31697" checksum="C38284F0D12FC590" modified="2011-06-28" version="1">MAVHAHPDDESSKGAATTAKYVAEGVDVLVVTCTGGERGSVLNPKLDRPEVWANIGDIRRAEMDAARAILGVEQAWLGFVDSGLPEGDPLPPLPEGCFALQDVEVAAGPLVRLMREFRPHVVTTYDEEGGYPHPDHIMCHKISVAAFEAAGDAERYPELGEPWQPLKLYYDIGFSKGKILALHEAILATGAESPYEEWLIRWEDRIDKGPRITTRVECAEYFPVRDDALRAHATQVDPDGFWFQVPMELQQQAWPTEDFQLARSLVDSPLPESDLFAGVRQTAHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5W8</accession>
    <name>F4F5W8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">OMP decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pyrF</name>
        <name evidence="8" type="ordered locus">VAB18032_22135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22135"/>
    <dbReference type="EnsemblBacteria" id="AEB45527">
        <property type="protein sequence ID" value="AEB45527"/>
        <property type="gene ID" value="VAB18032_22135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22135"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060704_0_0_11"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="30236" checksum="674C829DF47BFE03" modified="2011-06-28" version="1">MPLTREGTSFAGTWSRLSAQRGSLCLGVAPSASWLRRWELDDTSESLDRYGDIILEAAGDGVAGYKVQVPFYLRHGTAGLAALRRFVDGAHERDALVLLDAKVGDADDTMAAYADLYLGPDSQLGGDAVTTCAFMGTATLHPLLRIAQDSGTAVFTLVRTSNHGAGEVQGSRTAGGTSTAEAIADALTGWHTEHCGTDQPGPAAAVVGARPPESAQLVDRLPHSVLEIPGLGRADRRTEEVLAPVRDATDRAMLTVTTGVLRHGPAPTALRAGIRWWHEEIARHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F634</accession>
    <name>F4F634_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FolC bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_28576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28576"/>
    <dbReference type="EnsemblBacteria" id="AEB46786">
        <property type="protein sequence ID" value="AEB46786"/>
        <property type="gene ID" value="VAB18032_28576"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28576"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_2_11"/>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="82"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="335"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="477" mass="50213" checksum="2AEC14621A173753" modified="2011-06-28" version="1">MTDSNEHDDRSGAGRPASDGRPGRADERPERGKAAERAAFAEIEAELAGRGFTRMVFELDRISDLLDLLGSPQRAYPSIHLTGTNGKTSTARMIDSLLRAFGLHTGRYTSPHLETVRERISLDGEPVDEARFTAVYQEVKPLAELVDDRSAEPLTYFDMTTALAFAAFADAPVDVAVVEVGLGGAEDATNVIQAGVCVLTPIGLDHTEWLGDTLQDIAVAKSGIIHPGATVIAAAQEEEAARPILQRCAEVGATIAREGSEFGVLRRAVAVGGQVLTLQGLGGVYEEVFLPLHGAHQAQNAAVALAAVEAFLGAGARRQLDLETVREGFATASSPGRLERVRTAPTILLDGAHNPQGMAATVTALQEEFAFSKLVAVVGTLADKDAASMLELLEPVVDQVVVTRNSSPRALPADELAALAAEVFGPDRVEVAEEMPDAIEAAVALAEEDVPGELAGVGVIVTGSVVTVADARRLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6C7</accession>
    <name>F4F6C7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731744.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09775"/>
    <dbReference type="EnsemblBacteria" id="AEB43073">
        <property type="protein sequence ID" value="AEB43073"/>
        <property type="gene ID" value="VAB18032_09775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09775"/>
    <dbReference type="eggNOG" id="ENOG5032URV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108513_0_0_11"/>
    <dbReference type="OMA" id="MRVYVPL"/>
    <dbReference type="OrthoDB" id="1943830at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="172" mass="18403" checksum="1EBE8BFB5C87C632" modified="2011-06-28" version="1">MTDQLVRVYLSATVPMLTRLPEHGLAATQAHAVTPMLREWYAEGDEEELEYVAFTRAAQDALQLLHHDPAAPRRRVVVSADLPASALGRGDGELGSSLVELRGVVAANAVAALHVDGVDAVPDVTAAAKVVMEALAGDPDAQFTVDGVEDHELEWYDPSELELLLRDAADQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6E8</accession>
    <name>F4F6E8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09880"/>
    <dbReference type="EnsemblBacteria" id="AEB43094">
        <property type="protein sequence ID" value="AEB43094"/>
        <property type="gene ID" value="VAB18032_09880"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09880"/>
    <dbReference type="eggNOG" id="COG2343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126578_1_1_11"/>
    <dbReference type="OMA" id="FPPDSIV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="85" mass="9794" checksum="E9967D78F2D112CC" modified="2011-06-28" version="1">MIAESNDTVVVEGNHYFPRAALREDLIRDSDTHTVCPWKGTASYYTLEHAGRTSADAVWYYPEPFPEAEMVRDRVAFWKDVQVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6G0</accession>
    <name>F4F6G0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_09940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731777.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09940"/>
    <dbReference type="EnsemblBacteria" id="AEB43106">
        <property type="protein sequence ID" value="AEB43106"/>
        <property type="gene ID" value="VAB18032_09940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09940"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_0_11"/>
    <dbReference type="OMA" id="RYEDTDW"/>
    <dbReference type="OrthoDB" id="1469807at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="424" mass="45945" checksum="FFBC79AFE71AF933" modified="2011-06-28" version="1">MGVAEVNRSIDAVWRIESGRVIAALAGLVRDVSWAEELAQDALVAALEQWPRDGVPTNPGAWLTAVGKRRAIDGLRHRQVRDRKVAELGRDLGEGAFTPDFDAAFEDTIDDDLLRLIFTACHPVLTPQARAALTLRMVGGLKTEEIARAFLVPESTMAQRITRAKKTLAEAGVPFEVPGTADRPQRLASVLEVTYLIFNEGYAATAGQDWMRPALCEDALRLARMLQTLMPDEAEVHGLAALLEIQASRTAARTDAAGEPVLLLEQDRRRWDHLLIRRGLAALERARTSSDQAGPYTLQAEIAACHARARTAEETDWARIAASYTELAQVAPSPVVELNRAVAVSFADGPAAGLAVARPLASEPALARYHLLPAVLGDLLAKLGRYDEAAAEFTRAAELTGNAREQALLRDRAADCTAGVPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Q1</accession>
    <name>F4F6Q1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase zinc-binding domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">orfU</name>
        <name evidence="2" type="ordered locus">VAB18032_16365</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16365"/>
    <dbReference type="EnsemblBacteria" id="AEB44379">
        <property type="protein sequence ID" value="AEB44379"/>
        <property type="gene ID" value="VAB18032_16365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16365"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="OMA" id="QSIGWAS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEK75516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="30836" checksum="19DF4D6715F3EF5A" modified="2011-06-28" version="1">MQALIAAPDTAEGHRLAEVPEPVPTPGQLLVEVRQSSVNFGEARFRAGMPAGTVLGYDAAGYVVRAAEDGSGPAVGDRVVAFGPGTWAERAVFDVDSVARIPDGLDLAATAALPMVGLTALRTLRGAGPLLGRRVLVTGASGGVGRLAVQLARLGGATVVASVGSPARGEGLRDLGAAEVVVGLDDVREPVDVVVETVGGDHLTRAWSLLKPGGICQSIGWASGAAAVFAPNSTFALGEPRRLQSFGDTSRPGADLATLLAFVAAGDISLPVGWRDSWKRVDDAIEALLGRRVAGKAVLDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6S9</accession>
    <name>F4F6S9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734256.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22520"/>
    <dbReference type="EnsemblBacteria" id="AEB45604">
        <property type="protein sequence ID" value="AEB45604"/>
        <property type="gene ID" value="VAB18032_22520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22520"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037315_0_0_11"/>
    <dbReference type="OMA" id="IPRIFNI"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017031">
        <property type="entry name" value="Pre_MeTrfase_YjhP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034653">
        <property type="entry name" value="Mtase_yjhp_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="27409" checksum="3652265D48AF6DB7" modified="2011-06-28" version="1">MDLPRQFVIREGDLRILNPFDAEKLATLGRALKLAPGTSILDLCSGKGELLCTWARDHGVVGTGVDISTAFTAAARQRATELGVAEQVRFVHGDAAAYEGEALVDVAACVGATWIGDGVPGTLEILARRLRPGGMALVGEPYWRIEPPDQATVEGCDITNRDDFQDLPGLVGLFGEQGWDLVEMVLADQDSWDRYAAAHWLNLRRWLDDNPDDPLAGELRQELTEDPLRHVRYRRDHLGWGVFALIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6U5</accession>
    <name>F4F6U5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_22600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734272.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22600"/>
    <dbReference type="EnsemblBacteria" id="AEB45620">
        <property type="protein sequence ID" value="AEB45620"/>
        <property type="gene ID" value="VAB18032_22600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22600"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618124_0_0_11"/>
    <dbReference type="OMA" id="VISWARD"/>
    <dbReference type="OrthoDB" id="250960at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031768">
        <property type="entry name" value="CBM60_xylan-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16841">
        <property type="entry name" value="CBM60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312734" evidence="1">
        <location>
            <begin position="26"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="CBM60" evidence="3">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="158"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="443" mass="47949" checksum="CE8605B7E59B5063" modified="2011-06-28" version="1">MRVTRAIVAIVVVLSAGVLAGSANAAASSPFTVVNGSIQPATGTPEPASGTHATLWRNTSYALTTVQGAGTLVVGAIGDHCEGWPTIRVSVGGTPVGEVDVVSATDYGAYQVGAPLPAGQHTVRIDLVNDRYTGACDRNVHLAYVRTEATPPTDTRFSFAVVPDTQEEVLDAADNRFRQRIDWLVAQRNALDLRFVTHSGDVINYDTSDHVQYVRASNALRPLEQAGVPYTLAIGNHDGQVFGPDGKPRSPAGPLLRDTAVFNRYFTAARFGSVQGQFEAGKVDNAYATYTAGGVHWLVLTLELWPRRAAVTWAQQVVAAHPRHNVVLVTHHYLESDASIGQSAGFGASSPQYVFDNLVRRYPNIRFVFSGHTGTAASRVDTGVNGNRIYSFLQTFHSKRTNPVRLVEIDTAADSLRTWIYAPHTTENFPAHERRYTGLGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F741</accession>
    <name>F4F741_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735554.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29171"/>
    <dbReference type="EnsemblBacteria" id="AEB46905">
        <property type="protein sequence ID" value="AEB46905"/>
        <property type="gene ID" value="VAB18032_29171"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29171"/>
    <dbReference type="eggNOG" id="ENOG5031MWT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111071_0_0_11"/>
    <dbReference type="OMA" id="TCPFCLD"/>
    <dbReference type="OrthoDB" id="1992831at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010773">
        <property type="entry name" value="Mycophage_PG1_Gp7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07098">
        <property type="entry name" value="DUF1360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="178" mass="18845" checksum="6DE3D1F42FE08128" modified="2011-06-28" version="1">MSLLKQKVTRLRQAYAPHEHRPLGGYLVAMGTYAGVAGAIAALVKATGRTVPQRPATADVVLLSIATHKLSRLLSKDAVTSPLRAPFTRYDRPIGSGEVMEQVRDSGSPTRHAIGELLSCPFCLAVWVATGMTGGLVLAPRLTRLVATALTAVAASDFLQMAYAMAQQGAEGHHRSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7M7</accession>
    <name>F4F7M7_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_22820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734316.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22820"/>
    <dbReference type="EnsemblBacteria" id="AEB45664">
        <property type="protein sequence ID" value="AEB45664"/>
        <property type="gene ID" value="VAB18032_22820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22820"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_4_0_11"/>
    <dbReference type="OMA" id="ITTCRGL"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="36816" checksum="C6171CE73B317493" modified="2011-06-28" version="1">MSPARVTAVMLAYGPEPWLVDAAQAVLASTGVDVELIVVDNGCTSDGIDVVKGLPGVRVIRPEQNTGFSGGCNLGAAEAGGDWLAFVNSDAVVAPDALAKVTAVAAEPGVGAAMASIRLADNPELINTSGNPLHFTGLSWAGGNGEPAAAHARRTAVPSLSGCCFVISRERWEELGGFATEYFAYHEDTELSLRLWHRGLRLEYVPDAVVRHHYEFSRNALKLYLVERNRLVTLLTAYQGRTLALLAPMLLLTEAAMLAAALAGGWGRQKVRGWAWLWQHRTWVRTRRRQLQSERTVGDGTLAHLITARVAPSNVDAPPGMGVFNAIAAAWWTLVRPLLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7V0</accession>
    <name>F4F7V0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23185"/>
    <dbReference type="EnsemblBacteria" id="AEB45737">
        <property type="protein sequence ID" value="AEB45737"/>
        <property type="gene ID" value="VAB18032_23185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23185"/>
    <dbReference type="eggNOG" id="ENOG502Z8ZN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590316_0_0_11"/>
    <dbReference type="OMA" id="EWWLAGS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="470" mass="50070" checksum="4D8E59156E32000C" modified="2011-06-28" version="1">MRKVRREITASGAGLTGDRIVATGSTARILVAAIARALRGADCADISHVGPASRFVGTPDPVRRAVAIRSAGRVALTAGQAAELDAGQVAEWFVGQYPSGRYPGVLLGSPHGAAAHLAVALGVPWLPAGFEMIAHWPKGSVDRPLAALDHGAGLAGRMLAGNPDLHLRQVHCPASRGALAAATVALAGRWHRLPQAYRRFLADRLEPGAPVMVLRDTRTWPVYEAADGHSFQVGCPASGLDPVDFHPDSHTLRQVLRSAGGDGSHWEPPEISTPPGVAEHGVEPGFDRDVAQWTTREGHPLRQIVVPAPAALSAATADLYRRWLRAAGKTGNRLVVECGRLLDPWQVVRAGLVPYWCENATRRCVEQAEWWLAGSEAFSSVDVLPEPPGVRSPALAGLPQWLAVAGFGRRRRALDRSAARGYPVTSVPTRRATEVLRAQPYDLPTPPRIEVTDALAALRDSGAPHGLLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7X7</accession>
    <name>F4F7X7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735600.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29406"/>
    <dbReference type="EnsemblBacteria" id="AEB46952">
        <property type="protein sequence ID" value="AEB46952"/>
        <property type="gene ID" value="VAB18032_29406"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29406"/>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_11"/>
    <dbReference type="OMA" id="CGVAIDS"/>
    <dbReference type="OrthoDB" id="154460at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="28"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="562" mass="61437" checksum="8313371E5095D604" modified="2011-06-28" version="1">MNADEIAAGRARWQARYDAARKRDADFTTLSGIPVEPVYGPPEGVAYPGFDRIGWPGEFPYTRGLYPTGYRGRTWTIRQFAGFGNARQTNERYKMILGAGGGGLSVAFDMPTLMGRDSDDPQSLGEVGHCGVAVDSATDMEVLFDGIDLAAVTTSMTISGPAVPVFCMYLVAAERQGADLSTLDGTLQTDIFKEYIAQKEWLFDPEPHLRLIGDLMEYCATEIPRYKPLSVSGYHIREAGSTAAQELAYTLADGFGYVELGLSRGLDVNVFAPGLSFFFDSHVDFFEEIAKFRAARRIWARWLRDVYGATSEKALWLRFHTQTAGVSLTAQQPVNNVVRTAVEALAAVLGGTNSLHTNALDETLALPTDESAEIALRTQQVLMEETGVTNVADPLGGSWYVEALTDRIEAEAEEIFARIKQLGGEGPHAIGPMTSGILRGIEDGWFTGHIAESAFVYQQALEKGDKKIVGVNCHTGTIAKDLEILRISHEVEVEQRRALAERKTGRDDAAVRAAVDKMVAVSRTGENMIPAMLDAVRAEATLGEICDALRAEWGVYREPARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F864</accession>
    <name>F4F864_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_10535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10535"/>
    <dbReference type="EnsemblBacteria" id="AEB43225">
        <property type="protein sequence ID" value="AEB43225"/>
        <property type="gene ID" value="VAB18032_10535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10535"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_5_11"/>
    <dbReference type="OMA" id="QAEVWRF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="48"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="143"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="201" mass="21519" checksum="4AB5538F0DC761D7" modified="2011-06-28" version="1">MIPAPRDSAAADSDAADRRAQECPETADLATVAALAARDGDPAAQADFVRATQAEVWRFAAALVDPDSADDLTQETYLRAFRALPAFEGRSTARTWLLGIARRTCADHLRTVVRRRRLAQRLTADAYTDVPHPDPAGQFGAADLVRRLPTERRGAFVLTQLLGLSYAEAAAVEGVPVGTIRSRVARARSELVNAVGEALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8L0</accession>
    <name>F4F8L0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23275"/>
    <dbReference type="EnsemblBacteria" id="AEB45753">
        <property type="protein sequence ID" value="AEB45753"/>
        <property type="gene ID" value="VAB18032_23275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23275"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873440_0_0_11"/>
    <dbReference type="OMA" id="PFPLFRQ"/>
    <dbReference type="OrthoDB" id="1308935at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="35579" checksum="46CC76E66B1E1FAD" modified="2011-06-28" version="1">MTQAERRTRPPQAADKIQLPSDSRATSLFAPGDVPRRRGLIILLSLLGGFLLTVVWSAEFVDSTIGDNVANTLLGHDAKETPISGAVAGVIFAFVSGVAGTFTACNIAAFGALAPLTGTADSRMSRFLAPLRPLGWMAVGMIAISALYGAIVGLVGTAMPQFSTAPNVPGSLSPRSIQSMVVYGIIGLVMIYLGLAALKVVPDPFARISQRYPNAPLVFMGALIAGFLIGRPFPLFRQMFRDAAESGNPLYGAAAFTLQSIGNIVIMAIMFLLLSWFVGSRLQRWFAAKPSRLAATIAVAFIIAGAFMFLYWDVRLLARREIIPWYPVAPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8N8</accession>
    <name>F4F8N8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734433.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23415"/>
    <dbReference type="EnsemblBacteria" id="AEB45781">
        <property type="protein sequence ID" value="AEB45781"/>
        <property type="gene ID" value="VAB18032_23415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23415"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989764_0_0_11"/>
    <dbReference type="OMA" id="HQAIGWD"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="291" mass="30591" checksum="DADE0ED408884FA9" modified="2011-06-28" version="1">MHPDDDFDQKLPPQQQASQSADGSSPERVTGRHRAAIAPRRGIAAALGGTGLRVALATGVACCLGVTAVAVASTRDTDEAPRPQVAEAVADRVLAAEDGAASRSLERTSPSPTPSSSPSPSASPTAKPSATPKPKKTTAKPTKPPRPRPVAGLTQAQMDNAKVIVDVGVDMKIPRKGLVVAVATAMQESTLLNYASGVLPESQNYPHQAIGWDHDSVGLFQQRPSSGWGTVRDLMRPAYSARAFYEALLEVPGWEQMSLTLAAQAVQISAFPYAYAQHEERANTIVAALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8R7</accession>
    <name>F4F8R7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtC</name>
        <name evidence="4" type="ordered locus">VAB18032_23560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide</text>
            <dbReference type="Rhea" id="RHEA:42684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="EC" id="3.5.1.118"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.118" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23560"/>
    <dbReference type="EnsemblBacteria" id="AEB45810">
        <property type="protein sequence ID" value="AEB45810"/>
        <property type="gene ID" value="VAB18032_23560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23560"/>
    <dbReference type="eggNOG" id="COG0121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042555_3_0_11"/>
    <dbReference type="OMA" id="FSHNGAV"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02036">
        <property type="entry name" value="EgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017808">
        <property type="entry name" value="EgtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032889">
        <property type="entry name" value="EgtC_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03442">
        <property type="entry name" value="TIGR03442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="279" mass="29409" checksum="A7161812BE11560E" modified="2011-06-28" version="1">MPATPTPSRPAGDGGLMCRHLVYLGPPVTLREVLFDPPYSLLRQSWAPRDMRGGGTINADGFGVGWYPGDGPPVRYRRAQPIWSDPTIADLAAVTSTTAVLAAVRSATVGMAVIDGAAAPFTEGRWLFSHNGVVRGWPDSMVPLAAELPVRDLLTLDATTDSALLWALVRHRLRAGVAPEQAVAETVTRVAAAAPGSRLNLLLTDGHTAVATTVGHALSLRTTPASVLLASEPHDDEPGWREVPDGQLVRATATTVRQRALAGPCTTGTNRQASPKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8W4</accession>
    <name>F4F8W4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_29866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735692.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29866"/>
    <dbReference type="EnsemblBacteria" id="AEB47044">
        <property type="protein sequence ID" value="AEB47044"/>
        <property type="gene ID" value="VAB18032_29866"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29866"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_11"/>
    <dbReference type="OMA" id="DVFPRFA"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="42632" checksum="E866578567CD7CE7" modified="2011-06-28" version="1">MIEDMLRTPAAVQDAERHTAHNYHPLPVVISSAEGAWVTDVDGRRYLDCLAGYSALNFGHRHPALIAAAHAQLDKLTLTSRAFIHDQFADFCRELAALCGKDLVLPMNTGAEAVETGIKVARKWGYQVKGVPAGQATIVVAEGNFHGRTTTIVSFSTDDDARADFGPYTPGFRIVPYGDLTALAEAVDETTVAVLLEPIQGEQGVVVPPAGYLPGVRQLCTERNVLFIADEIQSGLGRTGATFACEQEGVVPDMYLLGKALGGGIVPVSAVAADADVLGVLRPGQHGSTFGGNPLACAVATEVVRLLATGEFQRRSTELGERLHAGLHALIGKGLVAVRGRGLWAGLDIDPALMSGREACERLMERGVLAKDTHGSTIRLAPPLTITAEEIDHAVAQLAAVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F901</accession>
    <name>F4F901_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_30051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735728.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30051"/>
    <dbReference type="EnsemblBacteria" id="AEB47081">
        <property type="protein sequence ID" value="AEB47081"/>
        <property type="gene ID" value="VAB18032_30051"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30051"/>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015667_2_3_11"/>
    <dbReference type="OMA" id="MGMTHGD"/>
    <dbReference type="OrthoDB" id="1588103at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="103"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="177"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="350"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="427"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="570" mass="63720" checksum="DBB50A9888374490" modified="2011-06-28" version="1">MAVSDIPARTGNLSARPPRAPRRARGEGQWALGHREPLNPNERIKKDDDPLNVRDRIENIYAHRGFASIDPQDLRGRFRWWGLYTQRKAGIDGGRTAVLEPHELEDEYFMLRVRVDGGQLDLAQLRTIAEISREFARDTADITDRQNIQYHWIRVEDMPEIWRRLESVGLQTTEACGDCPRIVLGSPVAGVAEAELVDPTPAIDEIVARYVGDKQYSNLPRKFKSSISWLVDTPYEANDIAFLGVDHPEHGPGFDVWVGGGLSTNPMLAQRLGVWVPLSEVPDVWAGVVGIFRDYGYRRLRHRARLKFLVADWGVTKFREVLEKEYLGRTLLDGPAPQLPDKPVDHIGVHRQRDGRNYVGAAPVVGRVSGTQLAQLADVVQAHGSDRVRLTPYQKLLVLDVPPERTESLVAGLREIGLEARPSAWRRGTMACTGIEYCKLAIVETKARGEELVARLEQQLRDFDADISIHINGCPNACARTQVADIGLKGQLVTGPDGRQVEGFQVHLGGGLGMAEGQTAGFGRKLRGLKTTADELPEYVERLARRYLAGRTEGETFANWVIRVDEEQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F909</accession>
    <name>F4F909_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spread protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04555"/>
    <dbReference type="EnsemblBacteria" id="AEB42037">
        <property type="protein sequence ID" value="AEB42037"/>
        <property type="gene ID" value="VAB18032_04555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04555"/>
    <dbReference type="eggNOG" id="ENOG5031RNE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179404_0_0_11"/>
    <dbReference type="OMA" id="GEPPEWI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="102" mass="11680" checksum="D70C4481FDC428B4" modified="2011-06-28" version="1">MTDQLPESTPVRMPYADEPDEQTPEPRRFYRLRAPHVDKASVPVTVRVTPDADLYLAVGSGRRRMYLTPAEAWALWRCLSEAVASTGEPPEWIRVHINPTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F946</accession>
    <name>F4F946_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_04740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730748.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04740"/>
    <dbReference type="EnsemblBacteria" id="AEB42074">
        <property type="protein sequence ID" value="AEB42074"/>
        <property type="gene ID" value="VAB18032_04740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04740"/>
    <dbReference type="eggNOG" id="COG2170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029030_0_0_11"/>
    <dbReference type="OMA" id="CRRRVNG"/>
    <dbReference type="OrthoDB" id="367541at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="492" mass="55167" checksum="8D56D7C366E984D2" modified="2011-06-28" version="1">MGRDVDRAAFSREDRVLYRQKVRRCLDVFALMLDDFGFDADRPMTGLEIELNLVDPAAEPAMRNEEILAAIADPLFQTELGQFNLELNANPRLISGAGFTDYERGLLGSLNRASERAARSDTRIVLVGILPTLTERHLVADNLSTNERYRVLNDQIVGARGEDIELDIRGVERLRTHTDSIAPEAACTSLQFHLQVAPDSFADYWNASQAIAGAQVAVGANSPFLYGRQLWAETRIALFEQATDTRPDELKAQGVRPRVWFGERWITSIFDLFEENVRYFPPLLPICESEDPVEVLHAGGVPELAELRLHNGTVYRWNRPVYDIMNGRPHLRVENRVLPAGPTVVDMLANAAFYFGLVRGLAEADRPIWSQLTFSSAEENFHIAARRGMDAVLHWPRLGEVPVTRLVLDVLLPIASAGLDAFGVAPAERDRLLGIIEQRCRTGRNGAVWQTATVWAAQRQRGLDRPAALHHMLQRYAELQGSNEPVHTWPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9C7</accession>
    <name>F4F9C7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11015"/>
    <dbReference type="EnsemblBacteria" id="AEB43321">
        <property type="protein sequence ID" value="AEB43321"/>
        <property type="gene ID" value="VAB18032_11015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11015"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079365_0_0_11"/>
    <dbReference type="OMA" id="TRGHDLP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="28178" checksum="80A9D0CA8FEB5BE9" modified="2011-06-28" version="1">MTTLRAAYDAQLRPGLPDPVPQGARVEQDGPLFRVFGLDDVGLVTYRDLGGAVDAELDALIARQTAVARERGEPVEWKLHGHDEPADLPQRLRAAGFVPQAQETVMVGPVAPLASALPVVPEGVRLREVTTRADLDRIAALETELWGHDVSGLADGLQREIAADPQAITVVVAEAGETVISAGWVRYPPDTTFATLWGGSTHPQWRRQGVYRALVTYRARLAGQRDRTLLQVDAADESRPLLGRLGLVPVTSTTPYVYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9V8</accession>
    <name>F4F9V8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23930"/>
    <dbReference type="EnsemblBacteria" id="AEB45884">
        <property type="protein sequence ID" value="AEB45884"/>
        <property type="gene ID" value="VAB18032_23930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23930"/>
    <dbReference type="eggNOG" id="ENOG503257P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2393244_0_0_11"/>
    <dbReference type="OMA" id="LMIDFRS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045635">
        <property type="entry name" value="DUF6412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19950">
        <property type="entry name" value="DUF6412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="93" mass="9811" checksum="0379C2BC780EC024" modified="2011-06-28" version="1">MIGLGMLWYLVGILADAGATGLVTGTAAATGVLLTVVLAAANLLRRVVTPAELRVTRRLMRERTRRTGVPRHRDPDAAGRARPRAPTATLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Z5</accession>
    <name>F4F9Z5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00110"/>
    <dbReference type="EnsemblBacteria" id="AEB47106">
        <property type="protein sequence ID" value="AEB47106"/>
        <property type="gene ID" value="VAB18032_00110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00110"/>
    <dbReference type="eggNOG" id="COG5282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031872_1_0_11"/>
    <dbReference type="OMA" id="LFAHVPW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="410" mass="43765" checksum="C055431374E0EF86" modified="2011-06-28" version="1">MQQFMSQLQHLLSAPGSGPVNWDLARQVAASQLAAAGDPAVSPYERNAVEEALRIADLWLEPASALPSGIRTVVAWNRNEWIFKTLDVWRKLCDPVASRMVGAMGDLVPPEARAQLGPMQSMVATLGGALFGGQLGQALGSLAAEVLSAGDIGLPLGPAGTAALIPANIRSYGEGLELPEDEVRLYVALREAAHQRLFEHVPWLRGHVLNAVETYAAGIRVNREAIEEAMGRVDPTDPESMQAIALEGIFTPEDSPTQKASLARLETALALVEGWVCHVVDGAAAGRLPNVVALGEAFRRRRAAGGPAEQTFAALVGLELRPRRLREAAALWAALTEHRGIGGRDALWGHPDLLPSDNDFADPVAFAMADVDLMTELENFDFTAPGGPEEKAPGEQDRRDDDPKGGDTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA36</accession>
    <name>F4FA36_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00315"/>
    <dbReference type="EnsemblBacteria" id="AEB47147">
        <property type="protein sequence ID" value="AEB47147"/>
        <property type="gene ID" value="VAB18032_00315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00315"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_9_0_11"/>
    <dbReference type="OMA" id="GWGQDWP"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307553" evidence="1">
        <location>
            <begin position="24"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="111"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="580" mass="62527" checksum="CDB8C7CB66068881" modified="2011-06-28" version="1">MRARLTTALCTATTLVAVLGACAANTGGSSTVDTGRQQTGVIATDPKDSWGPAPEVPGARAGGTFTIIRETPVSHLDPQRTYSFAGLMAAPLFARSLTTWKDDGQGNLVLVGDLAETPGSNVEDDCTVWEFKIKDGVRFEDGRPVTAKEIAYGIARSFDPDLTGGPTYLQEWLADTPQYDTAWDFGANRGALPPGLTTPDDRTLRFEFARPRCDLPFAASLPSTAPLPADRDTGINLGHAPFSSGPYKVTRFRAGVEIVLERNEHWDPATDPVRHQYPDRFVWSFGPTTDTAANRVIADNGADQAALSWDYVPASLVSRVAGDAALRSRTILSPTPTANHLVINNKRVTDLRVRQALNYAIDREGLVKVLGGPHVAAPNTTLMPPATIGHRAYDAYPAGRNGDPDRARELLGGQTPELVLGAADSSVEQQLATQLKGNLERAGFKITVRAIPDDAKLDEIKKRDNPWDLYLSSWAADWPSGAAILPVLYDGRGIRAAGNSNESYFDDPAISAEFDRILALPPAEQAPQWAGLDERIMREHAPVVPLYVDVAYLVHGSKVGGVFVSSVFGYPCLLDAHVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA53</accession>
    <name>F4FA53_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_00400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735809.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47164">
        <property type="protein sequence ID" value="AEB47164"/>
        <property type="gene ID" value="VAB18032_00400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00400"/>
    <dbReference type="eggNOG" id="ENOG5031UBD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1659480_0_0_11"/>
    <dbReference type="OMA" id="GMWVHHW"/>
    <dbReference type="OrthoDB" id="2130716at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="161" mass="17704" checksum="64848E39D1CF73D2" modified="2011-06-28" version="1">MASVVGRAAEPRQGQVPLDESVVQRFYERMRAVAPAAVGAIERDRADDPARTFADTACGRLLRSLDDDGVRALGMWVHHWCMRFYDDDTRAALRLLREIAGRPQLGWTADEVHWMLNESHQANSVAAARLTLPLAAAAELAPGTLRVDALIPRQTSPTPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAD2</accession>
    <name>F4FAD2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase s1 and s6 chymotrypsin/hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730867.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05335"/>
    <dbReference type="EnsemblBacteria" id="AEB42193">
        <property type="protein sequence ID" value="AEB42193"/>
        <property type="gene ID" value="VAB18032_05335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05335"/>
    <dbReference type="eggNOG" id="COG5640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_5_11"/>
    <dbReference type="OMA" id="NAWRGDS"/>
    <dbReference type="OrthoDB" id="1468733at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307759" evidence="1">
        <location>
            <begin position="27"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="33"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="226" mass="22976" checksum="8CF74E05FC292273" modified="2011-06-28" version="1">MRIRSLLAVLATALAGVLGASSGAVAAPVGPYIIGGGTVSSAPWAAAVFSNGSFTCSGTIIAPQWVLTARHCLGGTMSVRVGSVYYGSGGVTRTVSATYGRYDLALMRLSSSVSTSYVTLANSNPPVNSTNTIYGWGMTCYSGCGASPQLKTASVRVTSTNVTDAYGGQAIRSTRINGNAWRGDSGGPQFYNGAQVGVASTADGQSIQNYGSVAFNRAWITSVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAL5</accession>
    <name>F4FAL5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733285.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17640"/>
    <dbReference type="EnsemblBacteria" id="AEB44630">
        <property type="protein sequence ID" value="AEB44630"/>
        <property type="gene ID" value="VAB18032_17640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17640"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="HHGQKIA"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="260" mass="27396" checksum="F2B683275B16743C" modified="2011-06-28" version="1">MTDGLALHQVGVRFGGLTALDDVSLQVGPGEVVGVIGPNGAGKTTLFNVVCGFVTAHTGTLTLDGRPLRPRPHRLTRLGIARTLQGTGLFAGLTVLENVMTGATHTARAGLLPALLGLPRSDRDERRMREHARTVLDELGIAQHADAAPDTLPFAVRQRVALARALAARPRLLLLDEPAGGLGADDVDNLAELIRTLPHRSTDPCAVLLVEHHMDLVMAVCDRIVVLDFGRVVAAGPPEAVREDPAVVDAYLGATVDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAQ1</accession>
    <name>F4FAQ1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-amino-5-chlorophenol 1,6-dioxygenase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733321.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17820"/>
    <dbReference type="EnsemblBacteria" id="AEB44666">
        <property type="protein sequence ID" value="AEB44666"/>
        <property type="gene ID" value="VAB18032_17820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17820"/>
    <dbReference type="eggNOG" id="COG3384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1011734_0_0_11"/>
    <dbReference type="OrthoDB" id="1593426at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="275" mass="30083" checksum="C0E3D9142BF95E87" modified="2011-06-28" version="1">MADTGIVAGALLPGMPHLLAEKPAQCWADLAAAAREVGDRLRRLKPDVVLLLSTQWFTVLGHQFQCDPNPRGEHVDENWYAYDYGELRYDLRFDVPFTERWTDHVNKAGMQARRTRYDGFPIDTGTIVTSALLDPDRELRWAQVSCNLYADAQTLADVGAAGAAAAREAGVRAAVVVVTGMSSGLIQQWIEPHDDHVSDPGHDRWNRRVLDLLTAGKVDEVLKIREDFARQAQADSQFRALAFAAGAGATAGPAQLHAYGPLWGTGGAVLSWNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAQ6</accession>
    <name>F4FAQ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17845"/>
    <dbReference type="EnsemblBacteria" id="AEB44671">
        <property type="protein sequence ID" value="AEB44671"/>
        <property type="gene ID" value="VAB18032_17845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17845"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_11"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="26563" checksum="CDF546CEC275C414" modified="2011-06-28" version="1">MNEPSVLLERAGRLARITLNRPHRRNSFDLAMLARFEDVLHEVGRDSEVEVLVLTGAGSAFCAGTDLDELATLDATTTMHVQRRTAEVVERWYRMEQTTVTAFNGPAIGSGAVLGLAADLRVAADSCFFTFPEVTFGIPLTWSGMAILADLVGADRAKRWLLLGDRITPAEMLRHDLVTAAVPADELGAACDAVIERLLAVSPVGRSMTKRAARLAGPRFEAAANDSYLGALSVALRPAGAYPKGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB60</accession>
    <name>F4FB60_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00605"/>
    <dbReference type="EnsemblBacteria" id="AEB47205">
        <property type="protein sequence ID" value="AEB47205"/>
        <property type="gene ID" value="VAB18032_00605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00605"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="YEPAHPY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="341" mass="37225" checksum="C48D9C954764B5B4" modified="2011-06-28" version="1">MNVKLDALPGLDPNALPLEVKNLQVEFRTRNGIAHAVNGVSFDVRAGETRAILGESGCGKSVTAQAIMGILDSPPGFITGGEILYRGVDLLKLPEAQRRRVRANRIAMIFQDALSALNPVFTVGFQLAELFRKHRGMSRQDAKARAVELLDLVKIPAAKQRVNDYPHQFSGGMRQRVMIAMALALDPEVLIADEPTTALDVTVQAQIMALLAELQQERNMALVLITHDMGVVADVADRISVMYAGRVIEEAGVNDIYASPAHPYTKGLLESIPRLDLKGQELSAIKGLPPALTNIPTGCAFNPRCRYAQDVCRQNPGPPLYQVTPSRTSACHFWKEVKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBC2</accession>
    <name>F4FBC2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">idi</name>
        <name evidence="10" type="ordered locus">VAB18032_05460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730891.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05460"/>
    <dbReference type="EnsemblBacteria" id="AEB42218">
        <property type="protein sequence ID" value="AEB42218"/>
        <property type="gene ID" value="VAB18032_05460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05460"/>
    <dbReference type="eggNOG" id="COG1443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_2_1_11"/>
    <dbReference type="OMA" id="FPLRWAN"/>
    <dbReference type="OrthoDB" id="1345242at2"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="196" mass="21440" checksum="B06AD4AEA516B546" modified="2011-06-28" version="1">MSPSRESHLVELVDETGQPVGSTTVATAHQPPGRLHRAFSVLLVAPDGRVLLQRRAAIKTRFPLRWANSCCGHPQPGEPLSVAANRRLDEELGVGPVPLTEVGVHIYRAEDPATGRIEVEYDHVLRGEFRSDEPLHPEPSEVAELRWTDPVTLATQLIEDPDSYAPWLGGVLDRLLHPSSPAQLPPSDPSERSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBG6</accession>
    <name>F4FBG6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05680"/>
    <dbReference type="EnsemblBacteria" id="AEB42262">
        <property type="protein sequence ID" value="AEB42262"/>
        <property type="gene ID" value="VAB18032_05680"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05680"/>
    <dbReference type="eggNOG" id="ENOG50324D5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2195811_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="108" mass="12876" checksum="6F510CE10A7B0103" modified="2011-06-28" version="1">MTLRVQQFYILLYLQSYVGTVNEQVRRSDDQLRPGRRAVDPHPRGDLVPRVSYEEYLIATALTFARRHRPVWSWQKWRRICRCGADLPCHARHRIPINRGHWPGEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBI0</accession>
    <name>F4FBI0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="14" type="ordered locus">VAB18032_11640</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732111.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11640"/>
    <dbReference type="EnsemblBacteria" id="AEB43442">
        <property type="protein sequence ID" value="AEB43442"/>
        <property type="gene ID" value="VAB18032_11640"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11640"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_11"/>
    <dbReference type="OMA" id="QAFWYLI"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="191"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB43442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="376" mass="40144" checksum="5DC47581F19559A9" modified="2011-06-28" version="1">MGGTEDRNTRGTRAVHAALPEPLRDAVDEFARHLASVRNRSAHTVRAYVADLVSLLDHAHRMGCAEVAELSLDTVRSWLAKQRTMGAARASLARRAAAARTFSAWAHRGGLLPTDVAATLASPRPQRTLPTVLRTDQAALLVEAPTRHSTSPTHPTPDDHPVDDHPVDDHADSHRTADAHPTADGHGTAGGPVAAETGDGAGAEEVVAEAVRLRDRVLLELLYGTGVRVSEACGIDVADIDHGRRVVRVRGKGGRERVVPYGSPAQRALDEWLRRGRPVLVVPGSRDALLLGVRGGRLNPTTARQIVGAYAQATGLPRIGPHALRHSAATHLLEGGADLRAVQELLGHSSLASTQVYTHVSVDRLRAAYRQAHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBN6</accession>
    <name>F4FBN6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_11920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11920"/>
    <dbReference type="EnsemblBacteria" id="AEB43498">
        <property type="protein sequence ID" value="AEB43498"/>
        <property type="gene ID" value="VAB18032_11920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11920"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="FVYQSHR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="36"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="28096" checksum="DA00EA9BA595B88C" modified="2011-06-28" version="1">MSSGNEPTPALSNRSGQPGAGGQGSAPTATTTDAVLELRDVHRTHGNGPAAVHALRGVSLVVRPGELVAVMGPSGSGKSTLLTLAGGLDSPTSGEVHVEGQPLHALDRSGLARLRRRRIGYIFQNLNLIGSLTAVENVALPLELDGTGVRRARRLALDALTEVGMSELGDRVPDQLSGGQQQRVAIARALVGERRLVLADEPTGALDSQTGEAVLRLLRRRVDAGAAGVLVTHEARHAGWADRVVFLRDGLAVDSTAPLVGIESLLSGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBP5</accession>
    <name>F4FBP5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">rbfA</name>
        <name evidence="4" type="ordered locus">VAB18032_11965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732176.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11965"/>
    <dbReference type="EnsemblBacteria" id="AEB43507">
        <property type="protein sequence ID" value="AEB43507"/>
        <property type="gene ID" value="VAB18032_11965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11965"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_0_0_11"/>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="17844" checksum="C5A3F5DAA24EAF62" modified="2011-06-28" version="1">MTDPAKVRRHAERVRELVASVVRSQIKDPRLGMITITDARITADLRDATVFYTVLGDAAAQAGTAAALDSAKGMLRSTVGKALGLRHSPTLTFVLDDVQDQVKHIDDLLAAARNADAEVQRLAARAAYAGDAQPYRLEADDEDVDEAEDGDEAEGADSDGARGGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBX8</accession>
    <name>F4FBX8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18380"/>
    <dbReference type="EnsemblBacteria" id="AEB44778">
        <property type="protein sequence ID" value="AEB44778"/>
        <property type="gene ID" value="VAB18032_18380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18380"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092691_1_0_11"/>
    <dbReference type="OMA" id="NEFCVIE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="129"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="27925" checksum="2F2F328B274C9C65" modified="2011-06-28" version="1">MSNEMACHLFALCVDAHQPSRLARFWSELLRWNVTDDPLDGVALLPTDDTGFRLRFLASQEPKIGQNLMHFDLTSTSVEDQRQTVARALALGARHVDVGQGPEDEHVVLADPEGNEFCVIEPGNNFLAECGFVGALACDGSQQVGYFWAAALGWPLVWDQDQETAIRSPHGGPKITWGGPPLMPRLGRNRLHFDVVPPPGGDQQAEVDRLLALGATRIDADLDAGRGETNRGETGRSETGRVAMADPDGNEFCVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBZ0</accession>
    <name>F4FBZ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YceI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734640.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24450"/>
    <dbReference type="EnsemblBacteria" id="AEB45988">
        <property type="protein sequence ID" value="AEB45988"/>
        <property type="gene ID" value="VAB18032_24450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24450"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_0_11"/>
    <dbReference type="OMA" id="GARRDPY"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="221" mass="24276" checksum="F376F2DAD025EF61" modified="2011-06-28" version="1">MTGSTRIWNGMSIPAPGSYELDAGHKRIGFVAKHMMVSPVRGEFRQATARITVAEDPLESTIVATIQSASIDTANVDRDTHLRSADFLDVEQFPTLEYRSTGITALDKTDPIFYWAKLKNHRLGRRSVVEEPAPPTRPVTARFVLSGELTVKGITRPVDCQVEFGGARRDPYGQDIFGFSATAELNREDYGLVWNVALDSGGVLVGRTVRIEIAGEAIRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC62</accession>
    <name>F4FC62_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734712.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24810"/>
    <dbReference type="EnsemblBacteria" id="AEB46060">
        <property type="protein sequence ID" value="AEB46060"/>
        <property type="gene ID" value="VAB18032_24810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24810"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_11"/>
    <dbReference type="OMA" id="MGTEDQG"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="35514" checksum="E4E6E8B1A090C032" modified="2011-06-28" version="1">MSGARAVVTGGCGFLGSHLVERLVAQGDEVTVFDAAPPPPEQRIARQHSRHVTGDVRDPEALAAAIRPDVDVVYHLAAVVGVDQYLSRPLDVIDINFTGTRRVLERAAEVGARVVVASTSEVFGRNPAVPWAEDAERVLGPTTADRWTYSTSKALAEHLTFAFVRQHGLAATVVRYFNAYGPRQRPAYVVSRTVHRVLNGRSPVLYDGGRQTRCFTYVDDAVTGTLAAAASADAVGEAFNIGSMTETTMAEVVAVILRLTASTVPVTEVDTAQRLGAAYEDLSRRIPDNAKARKVLNWSCDTPLEDGLRQLVAWARANPDWLALPDQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC78</accession>
    <name>F4FC78_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">VAB18032_00865</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735902.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00865"/>
    <dbReference type="EnsemblBacteria" id="AEB47257">
        <property type="protein sequence ID" value="AEB47257"/>
        <property type="gene ID" value="VAB18032_00865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00865"/>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_0_0_11"/>
    <dbReference type="OMA" id="IVIGHGM"/>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
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        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
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        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
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        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
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        <property type="entry name" value="Nitri_red_NirB"/>
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    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
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    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
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        <property type="entry name" value="Rubredoxin_C"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIROHAEM"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="nitri_red_nirB"/>
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    </dbReference>
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        <property type="entry name" value="NIR_SIR"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="7 12" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="17">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="18">
        <location>
            <begin position="315"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="16">
        <location>
            <begin position="413"/>
            <end position="460"/>
        </location>
    </feature>
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        <location>
            <begin position="545"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="14">
        <location>
            <begin position="617"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="804"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AEB47257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="840" mass="88749" checksum="F2292AB51614100D" modified="2011-06-28" version="1">MTGGNVVVIGNGMVGQRFVDALRSRDPQGRWRVTVLAEEPRPAYDRVRLSAYFDGVSADDLNLHTAYDGVRLRLGEAALGVDRARRVVTTADGEYPYDMLVFATGSSAFVPPVDGVGLPGVFVYRTLDDLAAIEEHARGRRTGAVIGGGLLGLEAANALRLLGLSTSVVEFAPRLMPAQIDTAGGALLRRYVEELGVGCHLGVATTALRPGPDGTVAALELADGTLLDADLVVVAAGIRPRDELARAAGLDIGPRGGLLVDDACRTRDERIYAIGECAAVEGTCYGLVAPGYAMAEVVADRLVGGAATFPGADTATKLKLLGVDVASFGDAHGTTPGCLDVTYTDPATRVYAKLVLSDDATTLLGGVLVGDAGAYPTLRASVGGPLPAPPLALLAPAGAEGATVGALPASAQVCSCNAVTRADIDAAIADGCADVAALKACTRAGTSCGSCVPMLKQLLDAAGVVQSRALCEHFDLSRQELFDIVRVRGIRTFSRLIAEHGQGRGCDICKPVVASILASLGNGHILDGEQAALQDTNDHFLANLQRDGSYSVVPRIPGGEITPEKLIVIGEVARDFQLYTKITGGQRIDLFGARVEQLPQIWRRLVDAGFESGHAYGKALRTVKSCVGSTWCRYGVQDSVGLAVALELRYRGLRAPHKIKSAVSGCARECAEARSKDFGIIATETGWNLYLGGNGGFRPRHADLFATDLSTEALIQLIDRFLMYYIRTADRLQRTAAWIEAMDGGLDHLRAVIVDDSLGLCADLDAAMARHVTSYSDEWRDVLDDPDRLRRFTSFVNAPDVPDPSITFVTERGQPVPAGGRPATSEGRQPVTLGLPEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC80</accession>
    <name>F4FC80_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein</fullName>
            <ecNumber evidence="3">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_00875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.75" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735904.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00875"/>
    <dbReference type="EnsemblBacteria" id="AEB47259">
        <property type="protein sequence ID" value="AEB47259"/>
        <property type="gene ID" value="VAB18032_00875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00875"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_9_1_11"/>
    <dbReference type="OMA" id="DAVCFTT"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="269"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="269"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="362" mass="38786" checksum="9F3DF34101FEC4AE" modified="2011-06-28" version="1">MREELAGFTIGVTADRRRDELAALLQRRGARVVLAPALRIVPLADDSALREATRACLDRPPDVLMANTGIGMRGWLEAAEGWGVAEPLRSVLSDAYVVARGPKARGAIRAAGLYDQWSPESESCDEVVEHLRQRGVAGQVIAMQLHGDRQPECTRALEEAGATVIEIPVYRWAPPTDPAPLHRLVDLVAGRLVDAVTFTSAPAAEALLRAAGDRTEAVLAALRSDVLASCVGPVTAEPLVRRGVPVSAPSRARLGALVRTIVDELPRRTVTIKVAGHLLTLRGHAAVIDGELRPLAPAPMAVLRALAQSPGRVLSRTALLRTLPRGADEHAVEMAVARLRAGLKAPRVVQTVVKRGYRLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCA5</accession>
    <name>F4FCA5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735928.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01000"/>
    <dbReference type="EnsemblBacteria" id="AEB47284">
        <property type="protein sequence ID" value="AEB47284"/>
        <property type="gene ID" value="VAB18032_01000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01000"/>
    <dbReference type="eggNOG" id="ENOG5033WXY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852093_0_0_11"/>
    <dbReference type="OMA" id="QSQWDPW"/>
    <dbReference type="OrthoDB" id="1945039at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="360" mass="37912" checksum="4907F1F6EC1A93D0" modified="2011-06-28" version="1">MVYRYDSDEDAVVPYRDDSEGQPPPAAGAVPAGPSPSRFPAPSLPRPNQLVLPSTGTSMAASPPVQDAVPHYEATATAQYDLPAAVPPPQESTTAPPPRRGGGRTWQVLIGGAAALVLLALCGLAGAALLDGRQLINQQAAPNTTPDNTPGTDPTQASDLDSRDTDQAPLTAREVFPSSTLAIGDSQNGYEVLRTQSSASCPVAATGEVADLLVRLGCNQVVRATLRAPDQEHLVTTGLFNLTDRSSAERARDRIRQVLDERAGRFRGMPAGDGTDAIASAPARVGWQVRGHYVAYAVVSRADGATIRSGDTVVREILFDMLELHLNRDVLERRANGGVANQPSPEPTDSTGRQDGSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCI5</accession>
    <name>F4FCI5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA binding domain protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05930"/>
    <dbReference type="EnsemblBacteria" id="AEB42312">
        <property type="protein sequence ID" value="AEB42312"/>
        <property type="gene ID" value="VAB18032_05930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05930"/>
    <dbReference type="eggNOG" id="COG2452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2393241_0_0_11"/>
    <dbReference type="OMA" id="PANAGMY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="88" mass="9352" checksum="778692C6D1C80D50" modified="2011-06-28" version="1">MDTGDRLLTPGEVAALFRVDPKTVTRWAAAGRIGSIRTPGGHRRFRESEVRALLEGEGMLEEADEMGRARNVGPAATTGPGPANAGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCJ2</accession>
    <name>F4FCJ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NLP/P60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_05965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730992.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05965"/>
    <dbReference type="EnsemblBacteria" id="AEB42319">
        <property type="protein sequence ID" value="AEB42319"/>
        <property type="gene ID" value="VAB18032_05965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05965"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034352_0_0_11"/>
    <dbReference type="OMA" id="GDPYLWA"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313787" evidence="4">
        <location>
            <begin position="40"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="275"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="515" mass="53914" checksum="A0867D7CAD708F71" modified="2011-06-28" version="1">MVDSGHGRRQRRRPPVISPVLRPMLWSALLSAVATTVLAAPAYAEPGVPVTVPDTGSRPVVTGPLQLPGGTPATVTPGVIPTTSSPGASALEQQINAAEARIGELGTQLLDLKQQLTEAETQQATAARDLEFAQAALQQAQQLADQAAAQAIKVDAALPTAGFAADLLELDLLRRVNRGERAEHDTAPAAGELARAQTDAQVATQAYTAAESRLRGVQEQHTATEKALRDEEAKLVKLREQNATQLVELARQQERAEQQLGADYPTQSADGLIAHPTALAALAYARRQLGDPYVWGATGPNSFDCSGLVWSAYRSAGYYKLPRVARDQYYATRSRTVSRAALLPGDLLFFASGSSWRTIHHMGMYVGNGKMIHAPTSGDVVKISTVRWSRLYAATRVVGAVPAPSVTPTPTPKPTPKPTPTTPKPTPTTPKPTPTTPRPTPTTPSPTPNPTPTPSDTPPPSATPPGTTTPTPTSTGTPGDNGDSDGGDDTSPTTAATSLAPQESVSATPSAVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCN2</accession>
    <name>F4FCN2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ordered locus">VAB18032_12060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732195.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12060"/>
    <dbReference type="EnsemblBacteria" id="AEB43526">
        <property type="protein sequence ID" value="AEB43526"/>
        <property type="gene ID" value="VAB18032_12060"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12060"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_1_11"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="32"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="375"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="563" mass="60196" checksum="5966917566B15F89" modified="2011-06-28" version="1">MTEAHNEEAQLPPPLPEGGLRIIPLGGLGAIGRNMTVFEYDGKLLVVDCGVLFPDVEQPGVDLILPDFGPILDRLDDIQAIVLTHGHEDHIGAVPYLLAHKADIPLVGSQFTLALVEAKLAERRIQPYTLTVREGGRERLGPFECEFFAVNHSIPDALAVAIRTPAGLVLHTGDFKMDQLPLDGRITDLAGFARLGAEGVDLLLSDSTNAEIPGFVTPEREIGPVLDSIFAKARGRIIVASFASHVHRVQQVFDSALEHGRKVALIGRSMVRNMGIARDLGLLNIPAGLVVGLDEATSMPPEQIVLMSTGSQGEPMSALGRMASGDHRHITIAPGDTVVLASSLVPGNETSVYRVINRLARAGAVVVHKDVAKVHVSGHAPAGELLYLLNVVRPSNLMPVHGEWRHLRAHARLGIESGVAPDRVVLCEDGDVVDLVEGRASLVGRVKSRYVYVDGLAVGDVSESLLTERRILGDGGFIATTVVVDSVTGKVVAGPTVSAKGFSEDAAAFNAVIPLVTEALNRAAADGITDPHQLQQIVRRTVGRWVNDAYRRRPMIVPTVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD10</accession>
    <name>F4FD10_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733497.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18700"/>
    <dbReference type="EnsemblBacteria" id="AEB44842">
        <property type="protein sequence ID" value="AEB44842"/>
        <property type="gene ID" value="VAB18032_18700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18700"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760051_0_0_11"/>
    <dbReference type="OMA" id="PIFRTEQ"/>
    <dbReference type="OrthoDB" id="1341386at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="368" mass="37908" checksum="57642F907EA77173" modified="2011-06-28" version="1">MRHPTDGTLRRLLDEPAGVADADRAHVANCPVCLSGLAAARQDATLSAAALGGRPGVGVEADVDVDAGWQRLSRTVAESGRGRVPTVARERRWRAALRSPVVAAVAVLALVGGAGAAAAGNWLQVFHTERIAPVTIAQADLVALPDLSAYGEVEMTEPANVREVTDAAEAQRITGLPLPRLDRLPRGVTGEPTFQVGDRASAVFTFSVARAAQTAAAHGKPLPEPPAGLDGSQFRLTAGPGVAAVWAGQHGMPNLIVARMAAPTAYSSGIELSTAVDYLLSLPGLPENVAAQLRHFTGDGTTLPLPVNARYLTASPADVNGTPATVLTSRDGVLAGVVWVDGATVTAVAGPLSADEVVSVARGLRWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDH7</accession>
    <name>F4FDH7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">H(+)-transporting two-sector atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_01520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736023.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01520"/>
    <dbReference type="EnsemblBacteria" id="AEB47388">
        <property type="protein sequence ID" value="AEB47388"/>
        <property type="gene ID" value="VAB18032_01520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01520"/>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026429_0_0_11"/>
    <dbReference type="OMA" id="QATQFFI"/>
    <dbReference type="OrthoDB" id="756220at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="444" mass="47270" checksum="814E06B2571233D4" modified="2011-06-28" version="1">MRRFLRHPVRLVPLAFLLAIGIGTGLLMLPSMTVRHEAAPTLTALFTATSAISVTGLAVVDTPGFWSTPGLIVITVLTQIGGLGILTGAALVILTVSRRLGLHNRMLVQAETLEYGIGNLRRLLLHIGGTVLVCETVMTAIVTARLWLGYDYPLGRALWSGGFHAIQAFNNSGFSLYPHGLLSFSRDPWVSLPLALGSIIGGLGFPALFEAAREWRRPTRWAVATKLTIWGSAALVGLGFLTFLLIEWGNARTIGQYAVTDKLLAAFTQIALSRTGGIEVVSTTGLREESYPLLTGLMFIGGGSASTAGGIKVTTFFLLAFVIWAEIRGEPDVTVGHRRVATASQRQAVTVSLLSVAIVAVGTSLLIAVTNKVPFHSALFEITSAFSTTGLSAGVTSALPDSGLLLLTVLMYIGRVGPLTLGSAIALNTRHRLYRYPEEQPIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDI8</accession>
    <name>F4FDI8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-quinone oxidoreductase</fullName>
            <ecNumber evidence="9">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_06135</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731024.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06135"/>
    <dbReference type="EnsemblBacteria" id="AEB42351">
        <property type="protein sequence ID" value="AEB42351"/>
        <property type="gene ID" value="VAB18032_06135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06135"/>
    <dbReference type="eggNOG" id="COG1034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_11"/>
    <dbReference type="OMA" id="NVYFGRV"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0874">Quinone</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="12">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB42351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="831" mass="87630" checksum="93BACB21C65DF72B" modified="2011-06-28" version="1">MTDVAKSTETVTLTIDGVEVTAPKGALLIRVAEQIGTEIPRFCDHPLLAPAGACRQCLVEVEGQRKPVASCTQTVAEGMVVRTQLTSPVAKKAQEGVMELLLLNHPLDCPMCDKGGECPLQNQAMSTGRTDSRFHEHKREYPKPLPISTQVLLDRERCVLCQRCTRFSEEIAGDKFIDLMNRSSAEEINIYRDEAYGEEGDEGDVPFNSYFSGNTVQICPVGALTGTQYRFRARPFDLVSTPSVCEHCSAGCAQRTDWRRGKVLRRLAGDDPQVNEEWNCDKGRWGFQYARATDRLTTPLVRDQSTGELREASWSEALRVAAEGLRAARDGGQGSAVLTGGRLTVEDAYAYAKFARVALHTNDIDFRARPVSREEADFLASTVAGSTDVTYADVEKAPAVVLVGLEPEEECPILFLRLRKAYLKNKLKVYAIAPFATRGLEKLGAKLARVVPGEEAGVLAEHATVAEALSAEGAILIVGERLASVPGGLSAAAEVAARTGAKLAWVPRRAGDRGAVDTGCLPNLLPGGRLVTEPAARAELGEAWDIPAGVIPSQAGRDTDGILAAAAAGQLGALVVAGVDPADLADPRLAEQALDAVPFLVSLELRATAVTRRADVVLPVAPVVEKAGSFLDWEGRLRPFDAVLTTAAMTDGRVLDALAAQLDVRLGTGDVLSVRRELGGLPQTRTTRPGAPSVTPTAVPQPGAGEAVLSTWHQLIDLGSLTDGDEHLGGTARPPVVRLGKGTAEALGVADGDPVTVGTDRGALTLPVAITEMPDGVVWLPTNSPGATVRRSLGATSGAVVRISAPGTAESVAADAAGRPGPLLNSSGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEA9</accession>
    <name>F4FEA9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734827.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25385"/>
    <dbReference type="EnsemblBacteria" id="AEB46175">
        <property type="protein sequence ID" value="AEB46175"/>
        <property type="gene ID" value="VAB18032_25385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25385"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_2_0_11"/>
    <dbReference type="OMA" id="FNVTIVQ"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="239" mass="25304" checksum="DBF090AEE478EF9D" modified="2011-06-28" version="1">MSDVSPPEPARNVVLVHGAYADGSSWSDVIPILQRAGLNATAVQNPLTSLADDVAATRRALDRQDGPTVLAGHSWAGTVITEAGDHPNVSALVYVAARAPDVGEDYAALAAKYPTPPANAGLVHHDGFAQLSEEAFLADFAGGVDEARARALYAVQGPIAGDLFKARTTTAAWRDKPCYYSISTLDRTTAPELERFLAQRMHATTIEVESSHLAMVTHPEAIADLILKAAQGTKQHSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEC3</accession>
    <name>F4FEC3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BadF/BadG/BcrA/BcrD type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734841.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25455"/>
    <dbReference type="EnsemblBacteria" id="AEB46189">
        <property type="protein sequence ID" value="AEB46189"/>
        <property type="gene ID" value="VAB18032_25455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25455"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_3_0_11"/>
    <dbReference type="OMA" id="QFSPAIF"/>
    <dbReference type="OrthoDB" id="1589192at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="33224" checksum="92E33736EEB04B87" modified="2011-06-28" version="1">MSGSVVVGLDVGGTSTRALAVTLDGDRLGTGRAGGGNPTSHGAAHAAEQLLIALRQALTDVDPTRVRAGVIGLAGAGRLHADPAARTAVDHAWTAAGLRCPYAVHGDALIAYASGTADPDGTILIGGTGAVAAQVRDLRLDRVADGHGWLLGDAGSGFWLGRQAVRRLLTALDTGTDPGDLGRRVLTELTGSAEVAPHPRVTVDTLIQTVTRRPPVELARLAPLVLDAAADPTATTLITEAAALLIATLGRIRPPDDTRALVLGGGLLTGDNPLAAAVHAQARRHWSHAPIVPAGDGAAAAAWLAARDLPEATDPTALHTRLVPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FED1</accession>
    <name>F4FED1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase</fullName>
            <ecNumber evidence="1">5.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-L-Ala-L-Glu epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murL</name>
        <name evidence="2" type="ordered locus">VAB18032_25495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes epimerization of the terminal L-glutamate in UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate = AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:58812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:142725"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="5.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurL family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734849.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25495"/>
    <dbReference type="EnsemblBacteria" id="AEB46197">
        <property type="protein sequence ID" value="AEB46197"/>
        <property type="gene ID" value="VAB18032_25495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25495"/>
    <dbReference type="eggNOG" id="COG1365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045660_0_0_11"/>
    <dbReference type="OMA" id="CRFVFLA"/>
    <dbReference type="OrthoDB" id="306410at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02209">
        <property type="entry name" value="MurL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043689">
        <property type="entry name" value="MurL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="451" mass="48386" checksum="5BC25C4B9DBC9DA9" modified="2011-06-28" version="1">MPNTQLARMDSFTFPSYSIDLSTGEALFDYALTGPDGEQRFTEVITLPVPEQSPSDAAVAALGRVLELLHVVAGVSYYKAAAPGQLVLPAPLGPAAAEFVTAVYTKGLAEYAYRNQLPYVLELTPQIPQGRVRPAAEYDNSDRRPLSAVGGGKDSIVSLEALRRAGLDPVPFSVNPNHVIKAVNAASGLTALAARRRLDPVLFELNAAGARNGHIPVTAINSLIAVATAVLHGLGPVVMSNERSASDPNLIWNGHEINHQWSKGVAAEGLLRAALAEHAGLTEPYFSLLRPLSELHIARLFATIDRYDDVVTSCNAAFKLRDASERWCRDCPKCRFVFLALAPFMSRQRITHIFGGDLLADATQIPGYRELLGIDGHKPFECVGEVEESVVALSLLAQQPEWRDTPVVTALVAALPDTAWETAATSDTFTPSGGPSYVPPTYAKALNSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEI2</accession>
    <name>F4FEI2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_01700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736059.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01700"/>
    <dbReference type="EnsemblBacteria" id="AEB47424">
        <property type="protein sequence ID" value="AEB47424"/>
        <property type="gene ID" value="VAB18032_01700"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01700"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_5_11"/>
    <dbReference type="OMA" id="HVQDRWY"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="81"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="177"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="412" mass="45735" checksum="43DC3E833F1986AC" modified="2011-06-28" version="1">MAHIVDRWYRSIVGPDGKTRQEPKPECGQGMRYRVRYIAPDGKEKSQSFPDRKKREAQAFLANVQADILKGTYVDPDAGRTTFKQYADEWLAAATTDILTRDRIEYELRLHVYPVLGHKPMASIQPATIREWARRIQESGLSVGYRRVLFTDVSMIFNAAVDDRKIVSNPFSAKSIRRPKPAPTRVVPWSVDRLAAFRENLPLRYRVAVDLGAGCGLRQGEIFAVSPGDIDPTRPVLHVTRQIKLVRGVLIFAPPKGGKSREVPLPSSVAGRLRKHAQDCQPVAVTLPWGSLTGEPRTVELYLTNPAGTALTRSMFNSGVWKPAVRATGIPDDRHNGMHVLRHTYASVLLDAGESIKALSAYLGHADPGFTLRTYTHLLPASEDRTRRAIDRALGEDQADNDSSATDGLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEN3</accession>
    <name>F4FEN3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01955"/>
    <dbReference type="EnsemblBacteria" id="AEB47475">
        <property type="protein sequence ID" value="AEB47475"/>
        <property type="gene ID" value="VAB18032_01955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01955"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_2_3_11"/>
    <dbReference type="OMA" id="EQQAHIF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="422" mass="44846" checksum="74D8A312AAF6B5E5" modified="2011-06-28" version="1">MATVGALLATSGCAGDEDAAGDGKITLTVDVFGQLGYEQLYQEYMDANPNVKIVERGTGGNLDEYSPKLTQWLAAGKGAGDVVAIEEGLMVEYKANPDNFVNLLDHGAAELKGNFLEWKWNQGLTADGQKLIGLGTDVGGMAMCYRTDLFAKAGLPTERDEVSKLWPTWEDYIAVGERFKAADTGASFLDAATNTFNTIVLQTAGKAQGYHYYDTSNNLVVDSNPAVKQAWDTTMKIIGAGLSGKYGSWSEEWVSAFKQAKFATIACPAWMTGVIEGNAGAEASGKWDIARVPGDGGNWGGSHLAVPAQSKNKEEAIKLVKFLTSPQGQIGAFKAKGPLPSSPQALDDPAIADAKNAYFSGAPIGTIFAEGAKTLKPVYMGPKNQAVRTEVENAVRTVELGQRTPEQGWQDAVNNAKKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FER4</accession>
    <name>F4FER4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_06670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731131.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06670"/>
    <dbReference type="EnsemblBacteria" id="AEB42458">
        <property type="protein sequence ID" value="AEB42458"/>
        <property type="gene ID" value="VAB18032_06670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06670"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022305_0_1_11"/>
    <dbReference type="OMA" id="SAAMGGC"/>
    <dbReference type="OrthoDB" id="225730at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="12">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="11">
        <location>
            <begin position="187"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="252"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB42458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="505" mass="52861" checksum="A199E8D22B337198" modified="2011-06-28" version="1">MISVFDLFSVGIGPSSSHTVGPMRAARTFVHGLKGDGRLSEVSRVRAELFGSLGATGHGHGSDRAVLLGLAGEVPETVDTDTVDARVTEIRSRRRLALLGTHEIDFDPDRDLLLHRRRSLPYHPNGMIFSAYDGSGAEVRTRTYYSVGGGFVVDEAAAGADRIKPDSTEVRHPFVTGAQLLDVTASTGLSISEVMLANELSWRSEADVRAGLLDIWRVMQECVERGCTRDGTLPGGLKVRRRAAELRRSLEADAATPHPATPHQAAADAANPHPGTPHQSAAQPATERPVAERPANPQAGAAARAVDPLHVMDWVTLFALAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYTRFVPGASADGVVRFLLAAGAIGVLFKENASISGAEVGCQGEVGSACSMAAAGLAEALGGTPAQVENAAEIGMEHNLGLTCDPVGGLVQIPCIERNAVASIKAITAARLALRGDGVHAVSLDKVIKTMRETGADMKVKYKETARGGLAVNVIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEU4</accession>
    <name>F4FEU4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ordered locus">VAB18032_06820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731161.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06820"/>
    <dbReference type="EnsemblBacteria" id="AEB42488">
        <property type="protein sequence ID" value="AEB42488"/>
        <property type="gene ID" value="VAB18032_06820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06820"/>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_2_1_11"/>
    <dbReference type="OMA" id="FLMFESF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="12400" checksum="DB3357A0E29ACBF3" modified="2011-06-28" version="1">MTVLLVALGAAVGAPLRYLLDRAVQARHGSTFPWGTLTVNVLGSLILGVLIGGAGAGAVPGSLAALLGSGLCGALTTYSTFGYETIRLVETDARRYALANAVISVAAALGAAFLGVTLAEALWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF94</accession>
    <name>F4FF94_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-deoxy-D-gluconate 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19485"/>
    <dbReference type="EnsemblBacteria" id="AEB44999">
        <property type="protein sequence ID" value="AEB44999"/>
        <property type="gene ID" value="VAB18032_19485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19485"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_11"/>
    <dbReference type="OMA" id="KLDKAGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="253" mass="26591" checksum="CA2A0A766F9A9D04" modified="2011-06-28" version="1">MTMFDLGGRLAVVTGCRRGIGLAMAEALAAAGADVIGVSAALGETGSEVAARVGAQGRSFVPYRADLSDREAVRALARWLGQRDRPVDILVNNAGTIRRAPAAEHSDADWDHVLEVDLSAPFLLAREVGRDMVARGSGKIIFTASMLSFQGGITVPGYAAAKSGIAGLTRALANEWARHGVNVNAIAPGYISTDNTQALREQPERNQAILERIPAGRWGRPEDLAGITVFLASDAAAYLHGAIIPVDGGWLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFE9</accession>
    <name>F4FFE9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Parallel beta-helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46251">
        <property type="protein sequence ID" value="AEB46251"/>
        <property type="gene ID" value="VAB18032_25765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25765"/>
    <dbReference type="eggNOG" id="ENOG502ZB9C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025387_0_0_11"/>
    <dbReference type="OMA" id="DWGADGL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectate_lyase_3" evidence="2">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="252"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="557" mass="59385" checksum="E2A23C904978FE55" modified="2011-06-28" version="1">MVQQGRSVAIRQHPAPVAGAPLWCDAREYGLQGDGTTNDQPALAALVDRLGEGYAADGRARVIYCPPGIYSIRDAGTVWRSGVSLIGAGSGATRFLLSNEGNRAEPTPLAYWTTVQHGADRDRHIADCTFADFEIDGSGVAMTQYDYLAKGLGLQYVVRGVFRNLYIHHTGATGLGCDFLQDCLIDGVVAVGCGRLDNGEQMGGAGIGVGIGGWGDVERCTISNCTTLGNGTNGIFLELQKPYWTPPRGYRIIACHSQANRFGISDWGADGLIVSACTMTGNLEAGFDVSANGTAGIAGRGGILTSCVIDRNVGDGISVGNTPGPYTIEGNRISGNGRHGYHQHDLGNGFEGPAMDIVIDSNQFWDNGLDGIRIDRPTIDTVVVDNRIRNNGRQCAPAATGAGESVHYARRAMTDRSAHWPIDGHRGKVLRVGTRYAVVVANTDTDLSLADLRPDAENAWNEDVPPPGAAYELPSPVPIRAGITINSELRSATVRGNRIWDNRENPTQGYGMWITPQGSCVSCRVEDNDLAGNAEGALRLENPPEGGRWERNHAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFJ1</accession>
    <name>F4FFJ1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Transaldolase</fullName>
            <ecNumber evidence="6 7">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tal</name>
        <name evidence="8" type="ordered locus">VAB18032_25975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="6 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734944.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25975"/>
    <dbReference type="EnsemblBacteria" id="AEB46293">
        <property type="protein sequence ID" value="AEB46293"/>
        <property type="gene ID" value="VAB18032_25975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25975"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050771_1_0_11"/>
    <dbReference type="OMA" id="ATECYYQ"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="385" mass="41729" checksum="94CD842DF9483E5E" modified="2011-06-28" version="1">MTTDRLGELSAAKVAVWLDDLSRVRLSSGGLDQLRREKHVVGVTTNPTIFAKALSDADTYDGQLRDLAVRGVDVEEAVRMLTTYDVRWACDVMRPAYDASGGVDGRVSIEVDPRLAHEAERTVAEAKALWWLVDRPNLFIKIPATEDGLPAITATLAEGISVNVTLIFGLDRYSQVMEAFLAGLEQARANGHDLSTIASVASFFVSRVDTEVDKRLEKIGSDEAKALRGKAAVANARLAYERYSEVFGSDRWQALADAGAHPQRPLWASTSTKNPDYRDVIYVEELIAPGTVNTMPEAVIHAYAEHGETRPDTVTDAYDDARQAFERLAAVGVDMADVIETLEREGVEKFEASWQELLDGVRKSLVAAAQGTGHPGGAAQAGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG13</accession>
    <name>F4FG13_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein marr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13215"/>
    <dbReference type="EnsemblBacteria" id="AEB43757">
        <property type="protein sequence ID" value="AEB43757"/>
        <property type="gene ID" value="VAB18032_13215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13215"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_2_2_11"/>
    <dbReference type="OMA" id="KNGWVRR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="154" mass="17434" checksum="5C440091F7F4CEFC" modified="2011-06-28" version="1">MMAVMTRWLDPDEQRTWRAFLAASRALMDTLDRELQRDAGMPHAYYEILVRLSEAPERRLRMSELADATGSSRSRLSHAVTRLEAAGWVRREDCPTDRRGQIARLTDDGFATLAAAAPGHVEGVRRHLFDALSPAQVDQLRRISEALTDHLNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGE3</accession>
    <name>F4FGE3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733736.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19895"/>
    <dbReference type="EnsemblBacteria" id="AEB45081">
        <property type="protein sequence ID" value="AEB45081"/>
        <property type="gene ID" value="VAB18032_19895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19895"/>
    <dbReference type="eggNOG" id="ENOG503315W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_1_0_11"/>
    <dbReference type="OMA" id="SGNCVEM"/>
    <dbReference type="OrthoDB" id="1903180at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="79" mass="8432" checksum="6C70B07165A4D3D3" modified="2011-06-28" version="1">MQQPPNGVPANQLPPLAWLKSRRSNPSGNCVELAELPGGAGIAMRNSRHPEGPALIYTVDEIAAFVLGARDGDFDHLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGE6</accession>
    <name>F4FGE6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19910"/>
    <dbReference type="EnsemblBacteria" id="AEB45084">
        <property type="protein sequence ID" value="AEB45084"/>
        <property type="gene ID" value="VAB18032_19910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19910"/>
    <dbReference type="eggNOG" id="ENOG503281A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2792879_0_0_11"/>
    <dbReference type="OrthoDB" id="2212783at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="68" mass="7503" checksum="D57AAFDBBA6618C2" modified="2011-06-28" version="1">MEQPTGFVFAIDAVTRHVNSARPDAPVRPEPPRTPRLSGARHLAAVTLRRLADQIQPAPRTVTPHCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGF7</accession>
    <name>F4FGF7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative monovalent cation/H+ antiporter subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_19965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733750.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19965"/>
    <dbReference type="EnsemblBacteria" id="AEB45095">
        <property type="protein sequence ID" value="AEB45095"/>
        <property type="gene ID" value="VAB18032_19965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19965"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_2_0_11"/>
    <dbReference type="OMA" id="AFILQYM"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="892"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="10">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="9">
        <location>
            <begin position="125"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="12">
        <location>
            <begin position="597"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="11">
        <location>
            <begin position="790"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB45095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="940" mass="98477" checksum="693808AB3B729A05" modified="2011-06-28" version="1">MLVLVAVHALTAVIAPALVRLWGRHALYVVALVPGATLAWALTHTGEVRSGEPVVETLTWVPQLDLEIALRMGTLSWLMVVLVGGVGALVLAYSARYFRSDDPGLGRFVAVFVAFAGAMLGLVVSDDLLLLYVFWELTTVFSYLLIGYDPAKRASRRAAMQALLVTTLGGLAMLAGFVMLGQHAGSYRWSVVAENLPGGGYLAVALVLILLGALSKSAIFPFSFWLPGAMAAPTPVSAYLHAAAMVKAGVFLVALMGPAVAEVTPWRPVLLVGGLITMFLGGWSALRQVDLKLLLAYGTVSQLGLLMVILGAGTRDAALAGVAMVLAHALFKATLFLTVGIIDHATGTRDLRELSGVGRRAPALAVVAGLAAASMAGLPPMAGFVAKEAAVEALLHGGSAELAVLAGVIFGSALTVAYTLRYLWGAFADKPGVEPTTVRPVSWAILTPAAVLAVAGVAVGVLAPAVDRLLAPYADLYRSAEPGYHLALWHGLTPALGLSVLAVAGGAGLFDLMRRERVRATMRLPFDGAVAYKKCINAIDRLAVELTGRTQRGSLPFYLGVILVVMVVLPGGALLAGSPWPQRFHLWDTPLQGVAAAMVVIAAVMAARALRRLTAMILVGVAGYGIALMFILHGAPDLALTQFLVETVTIVMFVLVLRRLPAKFSERPIRSSRRGRVAIGVAVGAVTAGMAYVAAGARQAVPISVDFPDEAVSYGGGKNVVNVTLVDIRAWDTMGEIAVLVVAATGVASLIFRHARDLGRRGDIPGDGPTEYNRPRWLTTGATARSQSVILQVITRLLFHAIVLFSIYLLFSGHNAPGGGFAAGLVAGLALAVRYLAGGRTELNGAAPVDAGVVLGAGLFVAVGTGVAAMLLGGEFLQSALLDFHLPVLGHIHFVTSAFFDVGVYLIVVGLVLDILRSLGAEMDRQHETEGDEVREKELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGL1</accession>
    <name>F4FGL1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polar amino acid abc transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_26240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734997.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26240"/>
    <dbReference type="EnsemblBacteria" id="AEB46346">
        <property type="protein sequence ID" value="AEB46346"/>
        <property type="gene ID" value="VAB18032_26240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26240"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_2_11"/>
    <dbReference type="OMA" id="VFEYINL"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="35146" checksum="9DE2341995F07BD6" modified="2011-06-28" version="1">MSVDTDSPERARPEPIQAVPVRHPGRWVAVAVIGVLVAMFVHLLVTNEAFNWSFMIDNMFRPPIMAGVRGSLALLVTSMLIGIVLGVVIAIMRLSGNPILRGVAWAYTWFFRAVPRLVLAILFGNLGLLWSRIEFGLPFDRQIGALFGVQDFQARLFGFSARDLLTGFVAGMLALGLSEAAYMAEIVRAGIQSVDEGQTEAAQALGMTQGQILRRIVLPQAMRVIVPPTGNETIAMLKDTSLVAFVPVSTELFFQLRAVGSRTFQVFPMLVAATLWYLLLSSVLLVGQYYLERHFARGSGRAGQAKARLRGMAVGGGGAAGGAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH04</accession>
    <name>F4FH04_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_07480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731291.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07480"/>
    <dbReference type="EnsemblBacteria" id="AEB42618">
        <property type="protein sequence ID" value="AEB42618"/>
        <property type="gene ID" value="VAB18032_07480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07480"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151893_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="147" mass="16213" checksum="FC80340B696A8010" modified="2011-06-28" version="1">MSPSRRELTRERETFFRSLSSRAGRVLPCWVAGVVLIKVEEGDSGEFWRVAMRDRGVVVDRGSEPADATVVLSADLFHDLITGADQLIAALLRNEATVVGEVALLLVFRRFFPSAPGSGDPRDVVGGSRWRERMDETVARSTPAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH59</accession>
    <name>F4FH59_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732504.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13625"/>
    <dbReference type="EnsemblBacteria" id="AEB43837">
        <property type="protein sequence ID" value="AEB43837"/>
        <property type="gene ID" value="VAB18032_13625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13625"/>
    <dbReference type="eggNOG" id="COG4129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046662_1_0_11"/>
    <dbReference type="OMA" id="HREPFFA"/>
    <dbReference type="OrthoDB" id="1800547at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="398" mass="42026" checksum="563CAADCE93420F8" modified="2011-06-28" version="1">MAAGERNGSWARGAAGSARDRIAGTVAALSVRVDWRERRRTLELYAILAVQAGVAAALAWWVAHNLLHHPSPVFAPTAAVGTIAAAIGRRTRRTVELLLGVLAGLLVGDALIAVIGTGPWQTGTVVTLAILLALSLSRGGQVVTQAGGTAVLIATLAPVQRGLEVPRIVDAVIGGVTAVVVVAVLPVNPVRIIQRAARPLFAALIEHLHDAADGISRSDYPAVTQARDALSGLDPQLKLLKDAVSGAGEAVAISPARWHRRKEFEHYERGTRYLALAIRGGQEMLRRAATAIRDDEPVPSGLAAAVHYFGDALALLQVEAESGRPTDRSEQLILKAVDRAAEAYAEGVGFSGSVVVAQIRTVATDLLRSLGCDEQEASDVIRKRFDARYEITGQPDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHA3</accession>
    <name>F4FHA3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_13845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732548.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13845"/>
    <dbReference type="EnsemblBacteria" id="AEB43881">
        <property type="protein sequence ID" value="AEB43881"/>
        <property type="gene ID" value="VAB18032_13845"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13845"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_4_0_11"/>
    <dbReference type="OMA" id="FVMRTWM"/>
    <dbReference type="OrthoDB" id="1543624at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="57"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="299" mass="32964" checksum="FF90A9C8BA8EF405" modified="2011-06-28" version="1">MANSTLADPDSGLPPAQLAARHGLRMAGQRPSLGTYSRQLWRYRHFITAYANAKLAASFSNARLGQLWQVLTPLSNAAVYYLIFGLVLQQSRGMDNFIAYLTAGLFIFNFTQTSVQQGTQAISGNLGLIRALHFPRASLPLAITITQFQQLLGSMVVLIAIVLVTGEPITLMWLMLVPAVLLQTVFNAGLTMTVARLGAKATDLKQVMPFILRTWMYGSGVLYSVELFAENLPGWATAIVQFNPMLVYIELARVALLENTPLLNDSLPLTWLVAIGWSLVMGLGGYLYFWRGEQEYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHD4</accession>
    <name>F4FHD4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733761.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20020"/>
    <dbReference type="EnsemblBacteria" id="AEB45106">
        <property type="protein sequence ID" value="AEB45106"/>
        <property type="gene ID" value="VAB18032_20020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20020"/>
    <dbReference type="eggNOG" id="ENOG50347DB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2144807_0_0_11"/>
    <dbReference type="OrthoDB" id="2089495at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036648">
        <property type="entry name" value="CN_Hdrase_a/SCN_Hdrase_g_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027615">
        <property type="entry name" value="TOMM_nitrile_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56209">
        <property type="entry name" value="SSF56209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04351">
        <property type="entry name" value="TOMM_nitrile_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="11609" checksum="3FF8BFB9AE98716A" modified="2011-06-28" version="1">MAEGIYVLSDEDRRKFAKIVSSAWSDTEFADRYQNTPYEVLAEHGIDYPAAVAPPLLPPKPSGDLSMEALEAVAAGAAEGTLGSASSISTIGGTAFTASTAGTFGIEEPIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHK6</accession>
    <name>F4FHK6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20390"/>
    <dbReference type="EnsemblBacteria" id="AEB45178">
        <property type="protein sequence ID" value="AEB45178"/>
        <property type="gene ID" value="VAB18032_20390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20390"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149200_0_0_11"/>
    <dbReference type="OMA" id="YAGDYIE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="131" mass="13801" checksum="BCE2B062C0B4EAA8" modified="2011-06-28" version="1">MMSDSRVGLSVTHRRYVPYSHAHYAGDLVDGAYALGLFGDVATEVCIRTDGDEGLFASYSDVQFRAPIRAGDVLEVVATVTRVGTRSRTLDFEARVVCRGRPDRGGSAAAVLAEPVVVVTATGTVVVPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHL3</accession>
    <name>F4FHL3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_26420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735033.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26420"/>
    <dbReference type="EnsemblBacteria" id="AEB46382">
        <property type="protein sequence ID" value="AEB46382"/>
        <property type="gene ID" value="VAB18032_26420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26420"/>
    <dbReference type="eggNOG" id="ENOG50346CV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129791_0_0_11"/>
    <dbReference type="OMA" id="DYHEREL"/>
    <dbReference type="OrthoDB" id="1865442at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="15543" checksum="7F8433388BDB21C9" modified="2011-06-28" version="1">MGDGGMLDGFHIGHLPGGLGDLVSDFASEWEDVQITSRIWERQTADGYRVDLRVHVLRGPRLSDLDGLRAFLVDYHERELDDSQLVDFPHPDGPGRATDAQAFWLTEPGVAVTVLVDPEQFGQDALLTVAHSVVRPREQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHN9</accession>
    <name>F4FHN9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_26676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735059.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46408">
        <property type="protein sequence ID" value="AEB46408"/>
        <property type="gene ID" value="VAB18032_26676"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26676"/>
    <dbReference type="eggNOG" id="ENOG5030FPF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1711153_0_0_11"/>
    <dbReference type="OMA" id="DAWIFVS"/>
    <dbReference type="OrthoDB" id="1559961at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="17012" checksum="A776373CD0EA2CB4" modified="2011-06-28" version="1">MGENAWRRTDAWIFVSLVIASGAGRHRRSPTTRRPEGVRLADVLSTADHLDQSIPERHDIEEAIRRLLGAGLVDVADGWFRITPAGERLWRSRPTAGLATTVDTVQSVLDRRHAPGTAEWHLDEAEHAAAVQEYLVRTIPMPRQSPEGHSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHP1</accession>
    <name>F4FHP1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisA</name>
        <name evidence="10" type="ordered locus">VAB18032_26686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735061.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26686"/>
    <dbReference type="EnsemblBacteria" id="AEB46410">
        <property type="protein sequence ID" value="AEB46410"/>
        <property type="gene ID" value="VAB18032_26686"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26686"/>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_1_11"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="OrthoDB" id="794219at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010188">
        <property type="entry name" value="HisA/PriA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01919">
        <property type="entry name" value="hisA-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="241" mass="25256" checksum="9DCD49533B995B5C" modified="2011-06-28" version="1">MSLTLLPAVDVADGQAVRLVQGAAGSETTYGDPLEAALAWQRDGAEWIHLVDLDAAFGRGSNAALLAEVVRRLDVQVELSGGIRDDASLRAALATGATRVNIGTAALEDPQWCDRICGEYGDRVAIGLDVRGRTLAARGWTRDGGDLYEVLERLDKAGAARYVVTDITKDGTMRGPNLDLLREVCARTDAPVIASGGVSTLDDLRALATLEPIGVEGVIAGKALYAGAFTVAEALQALAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI54</accession>
    <name>F4FI54_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_30274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4 5">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AB-18-032</strain>
            <plasmid evidence="4 5">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30274"/>
    <dbReference type="EnsemblBacteria" id="AEB48018">
        <property type="protein sequence ID" value="AEB48018"/>
        <property type="gene ID" value="VAB18032_30274"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30274"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000181_8_6_11"/>
    <dbReference type="OMA" id="VGNFFGM"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="787"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1743"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1893"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB48018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1923" mass="210287" checksum="490D69560AB7B58C" modified="2011-06-28" version="1">MARLNANLAALRTLRTLQAEDRPATAEEQAVLARWSGWGAVPGVFEGRADHRDHARFAAAREQLRQLLDEREYAAAERNTLNAHYTDAAYVRAIWDAVTGLGFEGGDVLEPGCGSGTFIGLAPNGARLTGVEVEPVTAGIAAALYPHATIRTESFADTRAPAGAFDLTIGNVPFGKFVLADRRHNPGKHSIHNHFLIKGLHLTRPGGLVVALTSRYTMDTANPAARREMAALADLVAAVRLPTSAHEAAAGTKVVTDLLILRRREPGREPAGVAWEQIQEIDVPGGETIHVNEFFARRPDRILGDLSVGRGAHNAADLVVTGTGDTATDLARVLADVVDEARLAGLTLTPRVETGPAAPIAVLAAVGREEGHIEALDDGTFTTVVAGQVVEHKVPATQADELRALLLMRDTVTALLQAESSSLDDGDEHPDGPPAGSAAFLRIRLNTLYDAYVEQYGFLNRYDTYTRRQRNKVTGELETILDEETGQPKQYRNYPDMGKFRATDPYAATVFALENFNDDTRTATKADIFSKRVILPRAPRLGADSPEDALAICLDERGAVVLPEIARLLGVDEIQAREALGELVYDDPGTRRLVEAAAYLSDNVRAKLDQALIAAEDDPRFEVNVRALQRVLPRDVGPGEIMVSFGAPFIDYTEVQAFLQEILQDPQLRVSHPGGSDWQVKGSRTGVLARSTWGTAGMSAPELAQRLLTKTPIRVFYEVEKGKRALDVDATAAAQAKAVELEERFESWVWEEPERAARIAATYNRMFNAHVPRSYVGVQRSLPGISVEFKPRPHQIEAVTRIINEPGVGLFHCVGAGKTAVMAIGAMELKRLGLVNKPAIVVPTHLLEQFSREFLQIYPQARVLAAGQDDTSAARRQRFVARCATGNWDTVIMAASFFETLRLSDDEQRRFLDGELKELRNKIERAHTQAVANGEDPGRNAAVKRLQGALVRKESKIKEKFDKPTDPGVTFDQTGIDFVFRDEWHDLKNDTITSSIVDASNDGSDRAVDFRAKLDYLRRRYGPRVVCGATATPIANSVRELYVVTRHLRPDLLEATGTMDFDTWASVFGKVVTSVEISPTGSGFQTKSRLAKYTNAAELSLMLRNFGDIRTPEDLQLPTPQLTVNADGHRAPHVITIDPAPELVDFIATLDDRVEWCRQHPREREIDNILKISGEARAASLDLRLLGLAQNTPGKIDVAARNIAEIWQAHRETRYLANPDADNPVEHETPGALQIVFCDLGTPKPKDPDRWTAYEALRERLVDLGMPRESVRFIHEADSDKEKANLFAACRNGDVSVLIGSTGRMGTGTNIQNRAVALHHLDCPWRPADITQRDGRILRQGNQNDEVSIYRYVVTGSFDAFSWQTVARKGGFIDQMMRGTEAREIEDVSDETLQAHQIKAIATGNPLLIEKEELGMELARLERANRSHHNTHAALEKQIRELHQWITVDERRIEALDQTIARRQDIRSDKFRMTVTGHQFDKRPDAGRALQHALTAAAAGLGSTEQRDQVPLAELGGFAVTVTVWNGRDGILVSLMVNDDSGMTTQMSLTDATTGDATGLVRRLEHHLASLETRRGQLVANIARQNEEIDRARTQLGQPFARHDELVDTRRRMRAVSAAVDAIADLDSVPVNAAGTPAVPVTLDDGWMPDQIRNSLTDDERTWLSSRLHRVANAGTLQAAARAHDDIAAFAATFDKALTAMLGDPDQPNLSVAIFLKCDDPDWRANLFNAARRAVHDTIRATPVPAPVTGTTAAGPHRPGPDSAATLRVVLTEDEIRTLVPKLAAALTRDERIWLNQATARLCAHPDLRAIAQADDPDRFAQVFGPAITAQLADAPDRLAELAAGGDGLVDELRTLIQHYVYTKTRTDPEPSTGTAPASDAAKAAAVVATAFPSATTATPPPTTASAAAARGTAPATEPEPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI55</accession>
    <name>F4FI55_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_30279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
            <plasmid evidence="3 4">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30279"/>
    <dbReference type="EnsemblBacteria" id="AEB48019">
        <property type="protein sequence ID" value="AEB48019"/>
        <property type="gene ID" value="VAB18032_30279"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30279"/>
    <dbReference type="eggNOG" id="ENOG5031V6Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789727_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB48019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="37784" checksum="933237912A5137A3" modified="2011-06-28" version="1">MADNEMAEFQQRATAAVTAAIQAAGQIAQLLIDARIAELQRAARASEDRARRARAQARAAQQADAAVWRQATRASWWRRASADDIARAWRASATWSAVDPRARDAQRVMVERLAARGVHVDPETGMQPANEDWLADQLDHAAVESTDSAPATAHSAATTGEPRRTARQRQEEMADHIRQVWSPDRAERVIQSAAWLALAYKLDQLERAGHDVRDLLRRVPGFVDRAHTPAAYAFRVVVDYAADVDQAAAGKRAATDGQQNQEHPPVTIQGEWRESAGTVPGVTETHTDAAPDATGAVAHDVRAAQLAARGFPTSTKSAVADTAVAAHPQIGAQQRPARSAAPAASPQTASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1F9</accession>
    <name>F4F1F9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733842.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20440"/>
    <dbReference type="EnsemblBacteria" id="AEB45188">
        <property type="protein sequence ID" value="AEB45188"/>
        <property type="gene ID" value="VAB18032_20440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20440"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_11"/>
    <dbReference type="OMA" id="NMTEFRY"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="SSF50405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="715"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="814" mass="87875" checksum="ADB65F607BAA5D63" modified="2011-06-28" version="1">MTDRSTPPHQTRVDDLVAALTLPEKIGLLHQWQAPVPRLGLPGFRTGTEALHGVAWLGPATVFPQVIGLASSWNPELVRAVGVAVGEEVRAKHHADPQRVGLNVWAPVVNPLRDPRWGRNEEGWSEDPWLTGTLATAYAHGLRGDHPQRLRTAPTVKHFLAYNNETDRATTSSDLPPRVLHEYELPAFRAPIAAGAAVAAMASYNLVDGVPAHLSPLIEAELRRWAPGEVLVVGDAGAVSNLAGVQRHLPDHVSGFAAALRAGVDSFTEDDTDSAPTRQRLTEALRRGLISVADVDRAVRRILTLRCRLGDLDPPETDPYVTGTDVIDCPAHRRLAREAARQSVVLLRNDGLLPLAAPPRIAVLGPLADTVYEDWYSGTLPYAVTLHDALTARLPQVSTHAGADRIALRVAGRYVGCPDDADGGPLTVDVEPAWFDVFDWGRDTVALRAVGNGRHVGVDDDGVLVNDRPGPGGWVVRETFQFDPLPAGTVLLRHLATDRYVTVDADGRLRVDGDGPQAATAFVIELGVDGAAEAAALATDADVAVVALGNHPMVNGRETEDRVDLALPARQEALLRAVYAANPRTVLVVTSSYPYAIGWAEQHLPAVLWSAHGGQEHGNALADVLLGDAEPAGRLTQTWYADTAELPDLLDYDVIGADFTYLYHRGEPLFPFGHGLSYTDFDYTNLRLSATAVPAGAEVEVSVDVTNTGERVGEEVVQLYTRQRRSRVKQPLRQLRDFARVTVAPGECRTVTLRLRTAELSWWDADQGRLVVEDATHSVLVGRSATDVRLTGTVAVRGETLPCASRLSSTSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1H4</accession>
    <name>F4F1H4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733857.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20515"/>
    <dbReference type="EnsemblBacteria" id="AEB45203">
        <property type="protein sequence ID" value="AEB45203"/>
        <property type="gene ID" value="VAB18032_20515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20515"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_9_0_11"/>
    <dbReference type="OMA" id="PMPLDAY"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="15833" checksum="66A675F084FB5951" modified="2011-06-28" version="1">MLMRTDPFREIDRIAEQFFGTTSRPAVMHMDAYRDGDYFYAAFDLPGVDPDSIDCTVQRNVLTVRAERRRPTGDSVELVAAERPMGVFHRQLFLGDTLDTDKLEAGYDNGVLTLRIPVAERAKPRKVAISATGNGRKQINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1I2</accession>
    <name>F4F1I2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_20555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733865.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20555"/>
    <dbReference type="EnsemblBacteria" id="AEB45211">
        <property type="protein sequence ID" value="AEB45211"/>
        <property type="gene ID" value="VAB18032_20555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20555"/>
    <dbReference type="eggNOG" id="COG2270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_3_0_11"/>
    <dbReference type="OMA" id="WAFYDWA"/>
    <dbReference type="OrthoDB" id="1249292at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="270"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="464" mass="49652" checksum="C21404B3A4B57CBB" modified="2011-06-28" version="1">MAETVTPTAQDDAPPPASTRRERTGWYFYDWANSAFQTTVITVFLGPFLTSVAKVAAGCELGADCNGYVYPLGIKVAAGSYYPYLISLSVLLTVFVLPVIGAIADRSLHKKRLLAATAFTGAFATIGMIFVTGDRYLLGGLLFMVANISFGAAIVVYNSFLPQLGGPDERDGISSRGWALGYLGGGLLLALNLVAVQSFDNGTAERTLDLARWSIVSAGLWWAVFTLVPLRWLREHPTAAALAAGGRGNVLTDGFRQLGRTLREVKAYPLTLFFLLAFLVYNDGIQTVITLASQYGTEELRLDQSTLIVTILLVQFLAFGGALGLGALAGRIGAWKTVLLSLVLWTAVIVGAFRLPAEAPLPFMILGAAIGLVLGGSQALSRSLFSQLIPAGKEGEYYGFYEISDKGTSWLGPLAFGLVFQLTNSYRVGLVSLLIFFVVGFVLLLAVPMRRAIVAAGNTPPRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1M1</accession>
    <name>F4F1M1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733904.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20750"/>
    <dbReference type="EnsemblBacteria" id="AEB45250">
        <property type="protein sequence ID" value="AEB45250"/>
        <property type="gene ID" value="VAB18032_20750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20750"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_11"/>
    <dbReference type="OMA" id="FVGWWLL"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="188" mass="20855" checksum="CC84EEBB293F553C" modified="2011-06-28" version="1">MTQATLRTARLVLVPLADEHLAGEIALDADAQVMRFLGPVRSAEEVRGLHRRRLAVAGQAPGLGFWAGLVEGEFVGWWLLEPPQRADQGPVAGQAELGYRLVRRWWRRGLASEGARELIRHGFVDLGLRRIFAETMAVNVASRATMAAVGMRYVRTFHQSWSDPLPGAEQGEVEYEITREQWVVSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1R2</accession>
    <name>F4F1R2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylyl cyclase class-3/4/guanylyl cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_27071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27071"/>
    <dbReference type="EnsemblBacteria" id="AEB46487">
        <property type="protein sequence ID" value="AEB46487"/>
        <property type="gene ID" value="VAB18032_27071"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27071"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004435_3_1_11"/>
    <dbReference type="OMA" id="CPPFGEN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="6">
        <location>
            <begin position="73"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1208" mass="129249" checksum="75A5B4BF6B7F8FAF" modified="2011-06-28" version="1">MEGVIATQCDRCGRTAADGDRFCGGCGAELGAVCPHCLRPLAPDVAFCTSCGAPRAGNDRAPAIPQEDRRRVSVLFVDLIDFTPYVERADPELVRGMQTGFFSAARRVVGQYGGVVEKYIGDAVMALFGAPVATETDALRCVRAGLELQRVLTRFTPTGTDGLRFRVGVATGEALVDVAAARDGGQAIVAGDVVNTASRLQSVAPPGGVLVDGTTHALTRDTIRYAEQPPVTLRGRSAPTEVWLALAAVRQQPADREPDATPLIDREHELGMLVNALHRSLRDRRPQVVTVFGRAGIGKSRLVRELHRHTDRLVDEPLTWRIGRCPPFGENVTFAALADIVKAEAGILDTDPAGTAAQRLAAAVGELVGPGERDRVADALRPLVGLAGTPLPAEEAESAWRRFLLALAARRPTVLVFEDLHWADDAMLRFVELLGAAARDVPLLLLCTARPELVDRDPSWAGTITGSVTITLPPLRDTGIAALYAHMFGQAAFSADLLTPLIEVAGGNPLYAHEYVRMLIEQGALRQSGRGWSLEKHLDLPMPESVHAVIANRVDLLDAKERAVLLAAAVVGVQFWPGAVAAAVGQSVEAVERALRRLEQRDFVHEQGASTMAGQPEYRFRHVLVRDVCYQRLPRTERVARHERTADWLDTLSQSRDTDLAEVLAHHRWAAHEIARSLGMDTTRYAGPARAALHRAARRAYALHGLDAAAGHAGRALGLADDSDPVGRLQLELLSTEISFYRDGNAFLSGGGPEQVQTLADRLLAHGDEACAARAWTLLGQAAWLRADRQAALACLDHAVRLFEPLPDSAQKADAYAELGRLHMLNYERDAAVTAADTAAEIGERLGLTEIRTNARITAATARYQAGDRSGLDELYAIVEFSRGRQLLALPRATQNLAYAVREEGDWLRSDALLSAAPARTASGQTLTTSYSGEAMRAWFEGDFGRLLAAAEAFVDTPTGSWDMQVRGLRSCLLVLRGQPVPPAATPQAQTQRAAGAAASASDVADPTPLSAGQPSPPYDDVAAALDTARRSGFHRLHWTMLAMGALCRAVQGRTAEAAALVDELAEAWTKIPALASGEWIAAVGWAATLAGRRSAARVRAMLDQVGHRTPWSEAALRTVTAALTGADGDHRHAAELHLAAAEIYAGIPDVTDRMLSLTFAIRELTAGDDPAAAGPLLSELRAFAHRNAAPGLLALAHPPVGAQPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1S2</accession>
    <name>F4F1S2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27121"/>
    <dbReference type="EnsemblBacteria" id="AEB46497">
        <property type="protein sequence ID" value="AEB46497"/>
        <property type="gene ID" value="VAB18032_27121"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27121"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_11"/>
    <dbReference type="OMA" id="PRIWTKF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="42"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="618" mass="65966" checksum="841A4DA8F3E91040" modified="2011-06-28" version="1">MSRPAGGTRTGQCKHEGVQVREFSVPPIVTVGDSANLTDPVWENAEVAPDAVQFIRRDSQGGLVDVTCRQFRDEVVAVARGLVAAGVRPGDRVALMSRTRYEWTLVDYAIWAAGAVTVPVYETSSAEQAAWILADSGAVAAVVESTAHATLVAGVRDRLPELAHLWQIDLGGIDELMTTGNTVEPAEIEQRRAGLRSVDIATIIYTSGTTGRPKGCVLTHRNMYSDIANAVPVLPNLFGPNASTLLFLPLAHAFARLIQIGVVQARATMAHCSDVKNLVPELQEIKPTFVLSVPRVFEKVYNGAKQKAEAAGKGKIFARAEAVAIAYSEALETSAGPGLALRVQHALFDKLVYGKLRAALGGRCRDAISGGAPLGARLGHFFRGVGVPVCEGYGLTETSPAASANLPGFTRIGTVGRPLPGVTIRIADDGEVLIAGDIVFQGYWRNDEATAEAISSDGWFRTGDLGSLDGDGYLTITGRKKEIIVTASGKNVAPAVLEDQVRAHQLISQCVVVGDRQPFIAALITLDEEALPAWLESVGLPADTSAETLREHEGLRAEIQSAVDLANQSVSKAEAIKVWRILPQDFTEATGELTPSMKVKRQVVHKTYAAEIADIYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F201</accession>
    <name>F4F201_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_03320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03320"/>
    <dbReference type="EnsemblBacteria" id="AEB47748">
        <property type="protein sequence ID" value="AEB47748"/>
        <property type="gene ID" value="VAB18032_03320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03320"/>
    <dbReference type="eggNOG" id="COG5555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496898_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="540" mass="54368" checksum="5513108718D2AB40" modified="2011-06-28" version="1">MLAGLAVSAPAQAADEFRTITRDGLIMQYHRVAKAVTPVKGTGATRSDFDGDGVDDIAASAGWLNHSLPHYPTGVVVVRYSSAPHVDYFIGTGVDNISSFGIALVAGDFNGDGYDDLAIGDADEADTKKNNAHGGGVWIIPGSRTGLVVDSTKHFNQSSPGVPGESENRDAFGASLAAGDINGDGRDDLAIGAFKEAIGSVKEAGAVTILYGGSGGLTGTGAQQLHQNQAAVPGSAERRDHFGMSLAIGKVNNNKYADLVIGAPHENDGSGANGSGMVTLMWGSASGVKLSGATSVTGAGVYKATGRKDTIAWYLGMSLAIGDVNGDGLGEVIAGAPNAQTPHVDGGLIAVFTGRTGGAGLSGKAVKIITQRTAGVPGSPESADRFGATLAAGDVTGDGRADVLVGAYTEAIGTKDEAGMIVLLKGSSSGLTGTGAQGFDQNHSVVPGGAERGDRFGGSLALLNLNGKGPLDALVASTGEEVAGDIPGYPSATLSRFHGSSSGIVAQSGSWSGRALNTNRLELLNYGQRIAGPQSSGPWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F211</accession>
    <name>F4F211_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736390.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03370"/>
    <dbReference type="EnsemblBacteria" id="AEB47758">
        <property type="protein sequence ID" value="AEB47758"/>
        <property type="gene ID" value="VAB18032_03370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03370"/>
    <dbReference type="eggNOG" id="ENOG502ZNQN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048094_0_0_11"/>
    <dbReference type="OMA" id="YREPHPI"/>
    <dbReference type="OrthoDB" id="2073217at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="11874" checksum="D6C22FF55BB64CD4" modified="2011-06-28" version="1">MMPYSPSGLFPSGRPPRPTYREPHPVSGAAIAAGATGTTAWLVIFGLLGGTFTGYAWWTLIAGALAWLVSLVLVRYGDRGVATGIAIVTAGGWSIAAAAVAVRWWTSGDWPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F272</accession>
    <name>F4F272_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731432.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08215"/>
    <dbReference type="EnsemblBacteria" id="AEB42761">
        <property type="protein sequence ID" value="AEB42761"/>
        <property type="gene ID" value="VAB18032_08215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08215"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_656905_0_0_11"/>
    <dbReference type="OMA" id="HEQEGWL"/>
    <dbReference type="OrthoDB" id="1719870at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="404" mass="42026" checksum="EE23169F5D49CF3D" modified="2011-06-28" version="1">MNVEQDGLERAVREELSRRAAMPHATVPDPADAVIRRAKRIQRRRAVTGMSFAAVAMVMVSAGATQLGQEPPPNGTRVVIGEREQPPEVTWTPTAPAPSPANGTPLAEVDLVLGEAIATAQGRRVSIAGVGRIERAHRLADGRGWLVVSAPGLAGRFLWAVSPTGAVQVLLAGADEIVVDAEGHQVAWKQGSVLASARIINGELSPAARAEVPAEAMPLRIVEGAVLVRLAPDRPGHALWRLHPGVFEPGTDRSTSRIFGALPDGRLVGEVVTGTATCLTLLDPAGGLAPTGPECGPRLDGDGLGSVSPDGRWLLANGRSDDGDKALLVDLARLDRSVKPVVAGPAISGAVAWSTPSTAYYHADTVDRLARVDVDRATKGASPTLIALTGWPPDQPPVVVSHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F281</accession>
    <name>F4F281_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, fmdb family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08260"/>
    <dbReference type="EnsemblBacteria" id="AEB42770">
        <property type="protein sequence ID" value="AEB42770"/>
        <property type="gene ID" value="VAB18032_08260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08260"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_1_0_11"/>
    <dbReference type="OMA" id="TYQYQCT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="118" mass="11626" checksum="C74A8B03D90A1057" modified="2011-06-28" version="1">MPTYQYACTACGHQLEAVQSFSDEPLTECPACEGRLRKMFNSVGIVFKGSGFYRTDSRSSGSESTSSSTTSKSSGSDSSSSGTSTPSSPSSSSSSGSTGGSSSGSSGGGKAPAAASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2B9</accession>
    <name>F4F2B9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732658.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14395"/>
    <dbReference type="EnsemblBacteria" id="AEB43991">
        <property type="protein sequence ID" value="AEB43991"/>
        <property type="gene ID" value="VAB18032_14395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14395"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_4_0_11"/>
    <dbReference type="OMA" id="DHYHPWN"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="316" mass="34895" checksum="BBBAB738A96376B3" modified="2011-06-28" version="1">MKIGYFLSTEEYAPAELLAQARAAERAGFAALWISDHYHPWIDAQGQAPFAWSMIGALSQVTRLPVTTAVTCPTTRIHPAVLAQAAATSAVLHEGRFVLGVGSGEALNEHILGDRWPQAGIRLEMLEEAVEVMRKLWDGTFVNHHGRHYQVEHARLYTRPETPPPVYVSAFGPKAVDLAARIGDGFINTVPDADLVRRFRDNGGGDKPCQAGFKAAYAPTEQEGVRLAYERWPTEAIPGELLQVLPSPRHFEQAAQLVDPQAMREAIVCGNDTDAHLARIDAYAKAGFDEVYVANTGPHWQELLDLYQREVLPRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2F3</accession>
    <name>F4F2F3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732692.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14565"/>
    <dbReference type="EnsemblBacteria" id="AEB44025">
        <property type="protein sequence ID" value="AEB44025"/>
        <property type="gene ID" value="VAB18032_14565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14565"/>
    <dbReference type="HOGENOM" id="CLU_179376_4_0_11"/>
    <dbReference type="OrthoDB" id="2217544at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="70" mass="7679" checksum="F2D3307DC22C0791" modified="2011-06-28" version="1">MAKTLLDLDEDLLAEATAALGTATKKETVTEALRQAVESSRERRQRALADLQEVADGGGFDFDQLDELDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2G5</accession>
    <name>F4F2G5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732704.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14625"/>
    <dbReference type="EnsemblBacteria" id="AEB44037">
        <property type="protein sequence ID" value="AEB44037"/>
        <property type="gene ID" value="VAB18032_14625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14625"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OMA" id="YTVGAWE"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="328"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="426" mass="46059" checksum="00A99AECA0FF1995" modified="2011-06-28" version="1">MTSETADGWQRPGPTPEQQRVDLYAGLAATALALFSLTLAHSTGSFLLGPPPSGLEQILWTVAVPLPLICRRRYPTVTTLLISAAFIGSQVRAVPEWQLSQWALFAAIFTLGAWGRDRRLSRRVRVGVIVAMFVWLAISYGINLGSLPPDAFADAVGPVPPVLAAIVTGVLINVLFFGFAYFFGETAWVAARRQHEVAEQAEALRRSQAEARENAVVGERVRIARELHDVVAHHVSVMGVQAAACRRVFDKDPTKARTALTAIEESARTAVDELRRMLGVLRARDSEPDAPQQVAGIAQVEAVVTRAREAGLEATLGVYGDPTPLPESVSQAAYRVVQEAVTNVLKHATGARLLDVRIRYLAQEVEIEVTDDGRGSRAPNADGLGLIGMRERVATHGGELEVGPRTGGGWRVRVRFPLPVPTGRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2H7</accession>
    <name>F4F2H7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732716.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14685"/>
    <dbReference type="EnsemblBacteria" id="AEB44049">
        <property type="protein sequence ID" value="AEB44049"/>
        <property type="gene ID" value="VAB18032_14685"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14685"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_25_6_11"/>
    <dbReference type="OMA" id="QMKSSPK"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="199" mass="21700" checksum="23F56886FCD4AD18" modified="2011-06-28" version="1">MTSTADAPRPPGRPRSVRADEAIIEATLDLLAEGSTIEAISVEAIAARAGVGKATIYRRWAGKDALLHDALRTLKGEPPQPSGRSVREDLIALVGAVGQNIDPRAAKIMPCLVPNVKRNAEHYALYQSIVEPRRAVMREVLRRGIRDGELRPDIDVEVTLALITGPLLIQRMLNWNPDLDETTLPARVVDQVLAGIQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F352</accession>
    <name>F4F352_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736463.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03745"/>
    <dbReference type="EnsemblBacteria" id="AEB47831">
        <property type="protein sequence ID" value="AEB47831"/>
        <property type="gene ID" value="VAB18032_03745"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03745"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082726_1_0_11"/>
    <dbReference type="OMA" id="RRWFVEL"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="236" mass="25955" checksum="25638F40BCF2DBAD" modified="2011-06-28" version="1">MTEITGDQRIQSEVLEGLATAVNHRRWFVELAVPYLGDNPIEIGSGLGDYALEWAEHFPRFTATEADPDRLVALKERLADRPNIEVRQMLLPHSEQGDYSAAVSYNVLEHIEDHVGALRSMGELVRPGGAVVIIVPAFQFAMSPADIATGHVRRYTKKTLSAAMTEAGLRVEKIHYANALGLIGYFMATKVFRLMPKEGPMVKVYDTLVLPATKAAEQVLLPPFGQSVFAVARTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F389</accession>
    <name>F4F389_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_08475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731484.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08475"/>
    <dbReference type="EnsemblBacteria" id="AEB42813">
        <property type="protein sequence ID" value="AEB42813"/>
        <property type="gene ID" value="VAB18032_08475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08475"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="292"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="533"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="324"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="602" mass="65481" checksum="4295F3C1A83CB6A4" modified="2011-06-28" version="1">MANIVNLDRVSKGYGAAGPLLTDVSLGLDDADRIGVVGLNGAGKSTLLRLLTRAEEPDDGRVTHRRDLRVAWLPQNLTLSPDATVRDVVLGTEWLAESMGAEHEWAGDAGVRAILDGLGMPYLGLDTPVGPMSGGERRRVALAALLVREADLLILDEPTNHLDVGGVDWLARHLLGRKGALVVVTHDRWFLDAVCTTTWEVADQTVRAYEGGYAAWTLARVERERVAAATEARRQNLLRKEIAWLRRGAPARTSKPKFRIDAANALIADVPPPRDTTSLQRLATARLGKQVYDLEHVRLHAGPKTILEDATWQVGPGDRVAILGANGAGKTTLLRMLAGITHPDGGRLITGSTVRPAFLSQELRELPSELRVLEAVEEVARRVRLGDREISAAQLAEVFGFDDRRLWTPVGDLSGGERRRLQMLRLLAGEPNVLLLDEPTNDLDTDTLAALEDLLDSWPGTIVVASHDRYLIERVADTAYGMFGDGRLVHLPGGVEEYLSRAANRPGLNAAPGEPAAPTTTAATTSGMSAAEARQARKELTRLERQVSKLEQKEATLLDQLAANATDYNKVAELDAQLNQVRAEREQIEETWLALADEIPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3P8</accession>
    <name>F4F3P8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cbs domain containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_21245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734003.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21245"/>
    <dbReference type="EnsemblBacteria" id="AEB45349">
        <property type="protein sequence ID" value="AEB45349"/>
        <property type="gene ID" value="VAB18032_21245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21245"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_1_1_11"/>
    <dbReference type="OMA" id="PACIEET"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="233" mass="26210" checksum="7CEBFFF19A78D2FF" modified="2011-06-28" version="1">MRAWQVEDVMTRDVATVVEQTPYRQIVDLLAERRVSAVPVVDDFGHVLGVVSEADLLHKVEWMGEPHERRVFEGARQRRSRRKGEADNARELMTTPAVTTSPHTSLVAAAKLMDREQVKRLPVVDDMGRVVGIVTRSDLLRVHLRPDADIRHDVVQEVLRRVLAVREGAVRVEVRDGVVTMTGRLDRRSAVDIAGRLAARVSGVVEVVNELAFDFDDTDLPRFASFPVQPTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3S5</accession>
    <name>F4F3S5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734029.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21380"/>
    <dbReference type="EnsemblBacteria" id="AEB45376">
        <property type="protein sequence ID" value="AEB45376"/>
        <property type="gene ID" value="VAB18032_21380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21380"/>
    <dbReference type="eggNOG" id="ENOG50332WB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830651_0_0_11"/>
    <dbReference type="OMA" id="GRQLNHR"/>
    <dbReference type="OrthoDB" id="1863246at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="36311" checksum="37AFEAA93D6AE319" modified="2011-06-28" version="1">MSDPQLIDAVVEDSAEQDVPGFRKKRNLCRQLLLDDPAVYHIAHYTGGVLDFSLDLLAHDSAPAGRPDTDPTQRREAYRRVGAQLAYRAAELSRRVWHLQHGGLVRLAAQTRVDYVFCNTTVGGEHVVGFARTAAATDSVVDPAAASQTDQGAAKLATDLRGLVRQPSQNPGGWQTETYDPSSSDGDITPYLAEVGDSEAILTRALRPAGLHYLSHHRLGEQVSAVDILVHPDLEQFFNRGATVVDRRTGYQRLSRDLSLLALQVSRDLRRAITGEVERLVLDLEIGAVYYYLLAPDEYLFGVCLDQDWVSHADQAMWKVGGQLSRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F411</accession>
    <name>F4F411_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Erfk/ybis/ycfs/ynhg family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_27921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27921"/>
    <dbReference type="EnsemblBacteria" id="AEB46657">
        <property type="protein sequence ID" value="AEB46657"/>
        <property type="gene ID" value="VAB18032_27921"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27921"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086383_0_0_11"/>
    <dbReference type="OMA" id="NRRIGWV"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="151"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="29774" checksum="216056F2CFEC37EA" modified="2011-06-28" version="1">MLVGGSAYAGWALTPSAGPAPVARPSDQVPVPTVSVPTESAETVAPAAPAPDDLPEIDYDPAPVGFPDDPDALDTTPLTEGVRPQRRLAAYDGPGGRPIAFLMPTISGVDLTVPVARREAGWTAVLLPSANRKLAWLPPGGFDTVELRDQIVVERVPYRLTWYRDGVAKRSWRVSLGQRGQETPLGRTFVLGRTPPPESVYGGVDIYALGSVPDDPESVPAGLRGAHIGIHTWYHDGELGRQTTNGCIRLTPSGQRLLLKEVPPGSPVTVVDTLPTPPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F494</accession>
    <name>F4F494_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04125"/>
    <dbReference type="ESTHER" id="verma-f4f494">
        <property type="family name" value="Est9X"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47907">
        <property type="protein sequence ID" value="AEB47907"/>
        <property type="gene ID" value="VAB18032_04125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04125"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_10_1_11"/>
    <dbReference type="OMA" id="LIHGGCW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="117"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="27127" checksum="310B4AE217E896CF" modified="2011-06-28" version="1">MLSRPAPEPDLTVAYGEHPDQVADLRRPPGATPPRPLVIVVHGGFWRVEYDRRHTDSLAVGLARLGFPIAQLEYRRTGQPGGGWPVTLTDVRSGVSALPGLAAAALPGQVAPVPPILVGHSAGGHLALHTATRSPQDVGGVLALAPVVDLAEAYRLDLDAGAVAALLGGGPADVPDRYEVADPRATPPPSTRTVVIHGTLDQHVPVHMSRAYVQAAQALGADMHLVELPDCEHFGLIDPESPAWSQVTAAFRSLVEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4A9</accession>
    <name>F4F4A9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_04200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736554.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04200"/>
    <dbReference type="EnsemblBacteria" id="AEB47922">
        <property type="protein sequence ID" value="AEB47922"/>
        <property type="gene ID" value="VAB18032_04200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04200"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005571_0_0_11"/>
    <dbReference type="OMA" id="YLVPAHI"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="512"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="747"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="533"/>
            <end position="540"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1064" mass="116480" checksum="ADA751D4E9AC5B50" modified="2011-06-28" version="1">MPPFSAVPPGGLPPFVADLHIHSKYSRACSRDLTLPNLGWWARRKGISVLGTGDFTHPAWYDHLRETLHPAEPGLYRLSAEMERDIARRLPPRLASEADTDPVRFMLSVEISTIYKRDDRTRKVHHLIYLPDLDAVGRFNAALGRIGNLGSDGRPILGLDSRDLLEITLEASPDGYLVPAHIWTPWFSALGSKSGFDAIADCYADLAEHIFAVETGLSSDPEMNWRVGSLDRYRLVSNSDAHSPPALAREATVFAAPRDYFGIRDALRTGDGLAGTIEFFPEEGKYHADGHRLCGVNWAPERTRQAGGRCPECGKPLTVGVLSRVEELADRPQGYRPEHAREVTHLIQLAEILGEINKVGPRSKKVEGKLTDLVAALGPELEILTRTPLDEIGRVGGELLAEGIGRLRRGEVRRVPGYDGEYGVITLFDPAELSNSGASGGQETLFDVPVPAQRRPADSDRPVARVKRPATKAEPKRQPAPPPPPIAPQPSPHEPFEPMLAGMEEVGTGLLDRLDAMQRVAASAPGGPLLIVAGPGTGKTRTLTHRIAYLCAELNVFPEQCLAITFTRRAAEELRHRLDGLLGPVAEDVTVGTFHSLGLTILRENAEAAGLPGDFRIADDAERAAARAEAGDDLARYTGLLRKQGMVDLDELLTLPVALLRENRKLVQRYRDRWQWIFVDEYQDVDAVQYELLRLLSPADGNLCAIGDPDQAIYSFRGADVGYFLRFSQDFTDARLVRLNRNYRSSAPILAAAVQAIAPSSLVRGRRLDPARLDPEAPLVGRYAAASVADEADFVVRTVDELVGGLSHRSLDSGRIDGRSTTLSFSDIAVLYRTDSQAAPIVDALSRANIPVQKRSHDRLRDRPGVLAIARELRHASGVDGALPARVRLAGQVLAERFAIPTLDGSGGVRPEDVRTAVDLLTPLARRCGDDLETFLSQLATGAEVDALDPRAEAVTLLTLHAAKGLEFPVVFLVGAEDGLLPLRWPGSTPDDDAVAEERRLFFVGLTRAQDRLYVSHAARRVRHGSEHDCRPSPFLDVIDPGLFERLGDSDAPRRPKDRQLRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4I2</accession>
    <name>F4F4I2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron abc transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09110"/>
    <dbReference type="EnsemblBacteria" id="AEB42940">
        <property type="protein sequence ID" value="AEB42940"/>
        <property type="gene ID" value="VAB18032_09110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09110"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_0_2_11"/>
    <dbReference type="OMA" id="GQELAWK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="346" mass="38022" checksum="47E9964D660F691A" modified="2011-06-28" version="1">MAIAIAIGAMLAVTAGCGGSDDADTGSSGTPTAEKFVIYSARDKSVTDYVVEQFTTKNPEYKGKVEVLNMGAQEVLERVRAEKANPQASVWWGGTQQGLAAGASEDLLESWQPSFAAKMDARYKDEQGRWFGEILLPEIIMYNNKALTPQTAPQDWDDLIDPKWKDKIIIRDVAASGTMRSIYSSMIQRLSPDGSNPQPGYEWLLKLDANTVEYAANPADLYLKMSREQGVVSAWNLQDVLLQANEGMPFDYIMPASGAPVLVDGVAAVKGGNTAAAQKFLEFLFDDSLRATLAKDYFQIPAVEIGEKPEWLANLNLKPMDVDWDVIGKNETAWITHWNAEIKDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4P9</accession>
    <name>F4F4P9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15395"/>
    <dbReference type="EnsemblBacteria" id="AEB44191">
        <property type="protein sequence ID" value="AEB44191"/>
        <property type="gene ID" value="VAB18032_15395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15395"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078449_0_0_11"/>
    <dbReference type="OMA" id="RPGRCIK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="27322" checksum="8C8498143DF47237" modified="2011-06-28" version="1">MRGLLAAGIGAAAARYALRQVRTSPAGAGLARTNFRGRTVTLAAGPALAAGASGAAACGAASVPAGAATLLAGLGAGAVGLYDDVVGARPEQKAYKGFAGHLAALRQGRVTAGLVKIVGVGAAGLGAATLLAADQGVAGHRRRARQGPLGRGVDVLLGAGVIAGTANLLNLLDLRPGRALKSGLLLGAPLTAGRQGGIAAGAVGAAAGLLPADLDEDVMLGDSGANALGAVLGVALAARTGPVGRAALLAVLAGLTAASEKVSFTKVIASTPGLRDLDALGRRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F576</accession>
    <name>F4F576_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA internalization-related competence protein ComEC/Rec2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_28436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28436"/>
    <dbReference type="EnsemblBacteria" id="AEB46758">
        <property type="protein sequence ID" value="AEB46758"/>
        <property type="gene ID" value="VAB18032_28436"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28436"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010363_4_0_11"/>
    <dbReference type="OMA" id="RTDKQGA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4131" evidence="9">
        <location>
            <begin position="70"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="8">
        <location>
            <begin position="267"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="583"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="824" mass="83740" checksum="1BB47FDC3B480332" modified="2011-06-28" version="1">MTTDGAPTSRRTSAPAGLVRSGDGTFGAAGAIAGLDGAQIPDLRLAGLAVAAWLTALAGLHVDAGRALLVAAVAAGLAVLVALHLIGVAGRPGTIARRYGWIVVSVLIGVVCGGAATSARLAVRDAEPIRALVDDRAQVTAELVVRDDPRPVRGGIVGRPPTLLVRAKLVNVTGPAGQRVAVPARVLVLTDDPAWRQLLPGQRLTAEGRLTEPRGGDLTAAVLLAAGPPDRLGAPSALQRAAGRLRAGLQQACASLPDEPGGLLPGLVVGDTSRLPDAVEEDFRATGMTHLNAVSGSNVAIIAGAVLLVARWARAGPTLAAVLCGLALVGFVILVRPSPSVVRAATMGAIGLAALAAGRPRAAVPALAAAVAVLVLVDPDLAGDPGFALSVMATGGLLLLAPRWRDGLRRRGVPPGAAEALAVPAAAQLACSPVIAGLSGTVSLVAVPANLLVVPAIAPATVLGVVAATVSPVWPFGAEMAAWLAHWPAWWLVLVARYGARMPMGNLPWPGGVTGALLLAALTVALLVAARRPVVRRLVAVGTVAVMLGTVPVRVIAPGWPPKGWVIAVCAVGQGDTVVLPVAPGRAVVVDTGPDPGAADACLRRLDVRRVPLLVVSHFHADHTAGVAGVFRGRRVDLVSTPQWPEPATGRNQVHDTAATHGTRVVPVAAGWRYQAGAVDLFVVGPPYPMRGTRSDPNNNSLVLLATVAGVRIMLTGDAETEEQQALRERLPAHRLRADVLKVAHHGSAFQDAAFLDAIAPAVALVPVGAGNTYGHPSDALLARLSRGGARVLRTDVDGDVAVVLDASGLAVVLGGVDLSRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F582</accession>
    <name>F4F582_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ordered locus">VAB18032_28466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28466"/>
    <dbReference type="EnsemblBacteria" id="AEB46764">
        <property type="protein sequence ID" value="AEB46764"/>
        <property type="gene ID" value="VAB18032_28466"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28466"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_1_1_11"/>
    <dbReference type="OMA" id="IHIGHLI"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="188" mass="20783" checksum="D853805ACC9FC441" modified="2011-06-28" version="1">MGGTFDPIHHGHLVAASEVADRFGLDEVIFVPTGEPWQKADLPVSSAEDRYLMTVVATASNPRFQVSRVDIDRGGPTYTVDTLRDLHAMYGPKAQLFFITGADALERILSWKNLDEIFELAHFIGVTRPGFALSDAHLPADTVSLVQVPAMAISSTDCRARVARGEPVWYLVPDGVVQYIAKRRLYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5H5</accession>
    <name>F4F5H5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731678.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09445"/>
    <dbReference type="EnsemblBacteria" id="AEB43007">
        <property type="protein sequence ID" value="AEB43007"/>
        <property type="gene ID" value="VAB18032_09445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09445"/>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_0_1_11"/>
    <dbReference type="OMA" id="LIVCNEK"/>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="322"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="363" mass="38391" checksum="E8CD6AF6F0D945CC" modified="2011-06-28" version="1">MIYVVIPAGGSGTRLWPLSRAGHPKFLHPFTGTSASLLQATVQRAAPLTTPERTMVVTGAAHAAAVARQLTGLPEENILVEPSPRDSCAAIALAAAVIAVRDPDAVMGSFAADHLIGDPQSWVETVQAAIRGAEQGLLMTVGITPTRPETGYGYLQTGDPVGDGPMRPVTEFKEKPNAEVAEAYVRSGRYLWNAGMFVWRVSAFLAELARQQPALHAGVTSIAAAWGSDEQDDVLGAVWPTLPKISVDYAVMEGAASAGRVATVPGDFRWNDVGDFHTLGEVLPADADGNVVLGMDDKAEVLLRDSSGMVVVPQSGRLVATVGVRDLIVVDTSDALLVCPRDRAQDVKAIVDELKERGEDKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Z3</accession>
    <name>F4F5Z3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD linked oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734205.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22260"/>
    <dbReference type="EnsemblBacteria" id="AEB45552">
        <property type="protein sequence ID" value="AEB45552"/>
        <property type="gene ID" value="VAB18032_22260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22260"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_11"/>
    <dbReference type="OMA" id="YLHYSKD"/>
    <dbReference type="OrthoDB" id="1034540at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="474" mass="50769" checksum="33D8A68CD200ECA5" modified="2011-06-28" version="1">MNLVQRLTGLVGADHVLLGDAIGARYAQDLWGSDRVGTPTVVVRPADTGEVAAVLAECHRRRQPVVVQGGMTGLVGGGVPDAHEVVLSLERMTAIEEIDVVGATMTVQAGATLQQVQEAAERHGLMFPLDLASRGSCTIGGCLATNAGGNRVLRYGMTRDLVLGVEAVLADGTTLPGLHKLVKNNAGYDLKHLFIGSEGTLGVITRAVLRLQPLPRTRYVAFCGLPGVDAALALLGRLRAALPGSVSAFEAIWDEAYQLILPLRDTVRTPLVGRYPVYALVEIQGSDPVGDTERFVSALNGCDDLITESAVGLEPAEVAALWAVRERIPSLILGGEGPLFGFDVSLPATCLEAYLATVDRELRELWPQVSLQVFGHLGDGNVHIAVITGETTRRRKAEVEHIVYRNVERYHGSISAEHGIGFEKEPYLAYSRRPAEIATMRLLKQALDPHGILNGGRIFATGADRVRIESEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F607</accession>
    <name>F4F607_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734219.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22330"/>
    <dbReference type="EnsemblBacteria" id="AEB45566">
        <property type="protein sequence ID" value="AEB45566"/>
        <property type="gene ID" value="VAB18032_22330"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22330"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_0_11"/>
    <dbReference type="OMA" id="DNSGNWL"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="143" mass="15798" checksum="32083F7382D98DB1" modified="2011-06-28" version="1">MITNVSLTSVFVKDIDAAKAFYIDVLGFVERTDITIGDGSYRWCTVGHPGQPELEVHLQLPGPPLSPEVAELFARARDEGSLFALGLAVDDCRKTYDDLRAKGVEFLQEPADRPYGVEAVARDNSGNWLVLVEHKEFSPADFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F648</accession>
    <name>F4F648_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carbohydrate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_28646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28646"/>
    <dbReference type="EnsemblBacteria" id="AEB46800">
        <property type="protein sequence ID" value="AEB46800"/>
        <property type="gene ID" value="VAB18032_28646"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28646"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="LYMELLY"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="343"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="605" mass="65164" checksum="993CEFCFB7914DF3" modified="2011-06-28" version="1">MIRQAGGSLIEATRMAWAASRRWLIARVLLTVVGGMVPIAVAWLMKVVLDRLAAGDDRLTGPVLLLAGAGAAAVLLPELGRYVDAELQRSVGLAARHRLFAAVGRMLGLRRFEDPAFHDRLSIAAETGPAGPPEVVSGFLGAAQGLITMLAFLTTLAAINPWMVLVVAVAAVPTLRAELRLGRQRAALLWEYGHAARREFFYAQLMTSVTAAKEVRLYGLGGLFGARMLTELRGIQAGQRRMDRRELLVQSVQGLLGAVVAGLGLIWAVAAARSGALTIGDVSVFVAAVAGVQGGLSTAFVNAGRLHEAMLLFGHYRFVVEAPPDLPARATALPAVPPLRHGIELDDVWFRYGDDLPWVLRGVSLRIPAGSSVALVGRNGAGKSSLVKLLCRFYDPTRGSIRWDGVDLRDLPPAELRARIGVLFQDFMAYDLSAADNIGLGEVAALDEPARIRAAAQLAGVDDILSTLPRGYDTLLTRVYMNAEDRDDPTTGVVLSGGQWQRVALARALMREDADLLVLDEPSAGLDAEAEYEISRRLAAHRAGRTSLLISHRMNTVRDADLIVVLSDGTITERGRHQELIDLDGTYARLFRRQAAGYQDPQPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F686</accession>
    <name>F4F686_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28836"/>
    <dbReference type="EnsemblBacteria" id="AEB46838">
        <property type="protein sequence ID" value="AEB46838"/>
        <property type="gene ID" value="VAB18032_28836"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28836"/>
    <dbReference type="eggNOG" id="COG0380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_7_1_11"/>
    <dbReference type="OMA" id="YYGFSNR"/>
    <dbReference type="OrthoDB" id="556566at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
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        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="466" mass="52290" checksum="F5530C0479FFA5FB" modified="2011-06-28" version="1">MTVRSSFVVVANRLPVDEVSTPEGRQWRRSPGGLVTALHPVLAEHQGTWVGWAGGTGAAPEPFDLEGIRLHPVPLSAEELERYYEGQSNATIWPLYHDAVETPAYKRRWREAYRLVNARFAEAAAEVAADGATVWVQDYQLQLVPAMLRELRPDLRIGFFLHIPFPPIELFMQMPFRTEILRGLLGADLVGFQQRLAAQNFVRLARHLLGLRYEGQMIQVDGRQVKAGAFPISIDTKEMERLAADPAIQARAKEIREELGNPRTIILGVDRLDYTKGIELRLKAFRELLADGKLTVPDAVMVQVATPSRERVEHYQALRVKVEREVGRINGEFGRVGVPAVHYLHQSYSRTELAAMYAAADVMMVTPLRDGMNLVAKEYVASRADHGGALVLSEFAGAATELRQAFLCNPHDPDAVKDALLRAVHVEKPEARRRMRTMQRHLRTHDVGHWAKSFLTELGVPDMEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6D8</accession>
    <name>F4F6D8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_09830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09830"/>
    <dbReference type="EnsemblBacteria" id="AEB43084">
        <property type="protein sequence ID" value="AEB43084"/>
        <property type="gene ID" value="VAB18032_09830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09830"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_231242_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="PTHR13055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307445" description="LamGL domain-containing protein" evidence="3">
        <location>
            <begin position="44"/>
            <end position="2197"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="831"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="2197" mass="231319" checksum="39A38B01C79B7BC9" modified="2011-06-28" version="1">MSTALGIRGRNNRHRYVWRARTAGLAALVMVASSLVATSPAAAEPAAPAEPACVDEQPDARSAESMVAICQSRVEILSERTEVSQTFLNPDGSRTLEESLAPVRVRRGSSWVPVNTTLKATSQGVSPKASVLPVFLSTGGDGPLARVVDGSRELSVSWPDPLPAPELSGDTAIYREVLPETDLQVTASALGFSHVLVVRTPRAAKNSRLSELRFGMSTKGVTVKEGDGGTLVAHDDRGSAVFTAPAPLMWDSSVNSDLPGDELRLSSPPAGAAPARRKGEDPATAAADKDAKAKSADAAAREPAEGARRAVMPVKIGRNSLTIVPDKALLNSPTATFPIYIDPAWTGNISGSSWTTVWSKYKTSSFWKNASALNNGSTNGSAGAGRTEDCAGCGDHIIRSFFRMDVSGVKGKIIQAATFRIEQRHSWTCSPKSNAKLWLTGDISSSTTWNKQPTWNSSYTAQTAANRKNGAVHGCLGVGPIEFNVLSMVKKVAEQDKKSTMTVGLRAVDESTKNQWKRFNHSSPKLAITYNTKPAAPTDRKSDGRACATGSARPYVLTLTPTLAARQSDPDTGQQSLTTWFHWWPLGGSRNDTDRISQASGNPSTVSRAIPASKLVDGGTYVWQSRTHDGSHYSDWSGTCEFVVDATPPETPSNVASTDYPTGSTPRGGVGIEGTFEVTAPTLRRHEVKEYAWTLDSGTYLNAATVPARSGDYGATLTVKPVRDGTQTLRVWSKDHAGRYSATPRTYTFVVRAGAGPAAHWTFDEASGSAGDVTEHDNDLSLAGGASRTAGRSGVGSALSVNGTTGHGVVTGAVRYPHPDTNVLTSMRTDSSFTVTARVRVDSTNGVTGQRTIVSANGLRVFAYTLGYSGPDNRWRFTMAGADADNPALFSVLSNSAPTAGRWTHLAAVYDASTSTLRLYVNGVAQTATATLSGGFNAATNVTVGKRKWNGGDDGFFAGAIDDVRIYNFAESAANLAELAVPLPAVVAFPGGTEANTGSQLAVTFNAGGDTNVTKFRYSVGSTAVDTEVSASAPGGTATVSINVGSVVGERSLFVVAVDDGNRRSGLAQAYFEVTAATSLSGSVLDDADFSPLVGAVVTLEPGGFQTTSDNSGAYAFTGMPPGTYTLTASYGDRCGLTASATITITAGSPRWRDLYLAPYTDDSGYTCASRTASFATANETVLPLTGDNAVTEVSLPFAFPFYGQAYLSGWVDTNGYLTFIDPGGSHPKTNGTWPLPAAPNALIAPFWDDLVVDGSASVRTASTGSGADQRFVVEWRNVHRKGNTAQRLSFEVVLAPDGTITTNYDGLTSDPVRGAYAAVGIEAPDGEVGLAYSVDEPALASGQAVTFVHPQEDGTLELHDLSGVLRDENGNPVVGATVTLDPRGLSTTTGPGGAWGFEDLVADSYTVSTRVGARCGRSAEDQVELDDNRTVDLRLGPDHGTMGYACVVGASGYVAASNVVALTGDDAWANLNLPFPFTYHGRPYSKAWLHTNGLINFGAEPGNVQQIWVNPTMPTAAIPNGVIAPFWDDLNVDSSASIRTELLGSAPNRRFVVEWRNVLMQGVAAPNNRVTFELMLHEDGRIGFHYGTLTTPIQQGAGATVGLESTERAEVAALYSFQTAVVPSNGSIVYSPNTSGTVRGTVTTAVTSEPVAGRTVTLTPSGATTTTAADGSYEFTGVPIGEHVVAAATGDDRCAGQYAREVFNFAGGTTSWIDLSVMIDGDEFGYGCRTGSQPFIPGNVTESWSGDDTVWQKNPPFPIKLYGESYTSAWISANGVMTFRNPAFHGWIYANSTPIPSPLSEGRPNAAVYVHWNDWIVDSAARIATATSGTAPNRRWVVEWRNVHLYGDTSARASFSAVFDENGDVTFTYADINPAHAGERGSAATVGIENGAGTIAFQYSHKEAVLATGKGIFFKPNPPGSGVVSGTVTCQGTPVAGATVAMAGRSATTSAGGGYQFDDVPGGTYAVIVTLSSGPCVGSAVTPVTVGTNTTSAVNFDRGATPSGARYTIAEQPVSFVPADGTVLPLTGDDAYTPITLPFPVTHYGQTYTTAWVDTNGLLTFVEPAASSPDAWPIPSSAESQLPKAAIYPLWHDWIVDADASVRTATTGSGPNRRFIVEWRNVRSYEDPTTRISFEVIMDEAGGYTFAYTDNDGTHIEQGGASTIGIDNADGTSALRYTYRQPVLHPGTGLRIERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6T5</accession>
    <name>F4F6T5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">ureB</name>
        <name evidence="3" type="ordered locus">VAB18032_22550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734262.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22550"/>
    <dbReference type="EnsemblBacteria" id="AEB45610">
        <property type="protein sequence ID" value="AEB45610"/>
        <property type="gene ID" value="VAB18032_22550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22550"/>
    <dbReference type="eggNOG" id="COG0832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129707_1_0_11"/>
    <dbReference type="OMA" id="FYEVNDA"/>
    <dbReference type="OrthoDB" id="1755809at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="109" mass="11222" checksum="C1C38C9851F1C249" modified="2011-06-28" version="1">MIPGEILLAADPVEINAGRPVTTLLVVNTGDRPVQVGSHYHFAEANPALDFDRDIAWGQRLAVPAGTSVRFEPGVSRSVDLVPLAGARIVPGLRGECGGALDAEPGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6V5</accession>
    <name>F4F6V5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_22650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734282.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22650"/>
    <dbReference type="EnsemblBacteria" id="AEB45630">
        <property type="protein sequence ID" value="AEB45630"/>
        <property type="gene ID" value="VAB18032_22650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22650"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="QSIVTFP"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="241" mass="25633" checksum="C317EB38C7211B6B" modified="2011-06-28" version="1">MASRTSSQLTGPLLTATGVRRRFGATTVLTGVDLRIAPGEVVALLGGSGSGKSTLLRVLAGLDDEATGEITLRGQAAVVFQEHRLLPWKRVADNVALGLSGPDVAERVARALAEVGLAERHRAWPAELSGGQAQRVAVARALVREPDLLLLDEPFGALDALTRLRMQGLLRRLRAEHGFAALLVTHDVEEALLLADRLLVLEAGVIAEELPVDLGPTRSPDDPAFGALRRRLLDRLGVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6V7</accession>
    <name>F4F6V7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22660"/>
    <dbReference type="EnsemblBacteria" id="AEB45632">
        <property type="protein sequence ID" value="AEB45632"/>
        <property type="gene ID" value="VAB18032_22660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22660"/>
    <dbReference type="eggNOG" id="ENOG502ZQJB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_211607_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="47" mass="4874" checksum="FD9C4AF0F97C02BA" modified="2011-06-28" version="1">MTKLEPQPSPTAPESRFSINEDWAATILGLALLCLVLAGAIPAGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F736</accession>
    <name>F4F736_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735549.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29146"/>
    <dbReference type="EnsemblBacteria" id="AEB46900">
        <property type="protein sequence ID" value="AEB46900"/>
        <property type="gene ID" value="VAB18032_29146"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29146"/>
    <dbReference type="eggNOG" id="ENOG502ZJI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2735591_0_0_11"/>
    <dbReference type="OMA" id="GMSHDQT"/>
    <dbReference type="OrthoDB" id="2061109at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="71" mass="7728" checksum="C4065464ADD26AFB" modified="2011-06-28" version="1">MSDAKSDQERVESRAHLLPEEAAAGSEDPEAQADAILTESDIREDNPNAAPDTILERRTSEQTVTPIEPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7D8</accession>
    <name>F4F7D8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rph</name>
        <name evidence="7" type="ordered locus">VAB18032_10390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731867.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10390"/>
    <dbReference type="EnsemblBacteria" id="AEB43196">
        <property type="protein sequence ID" value="AEB43196"/>
        <property type="gene ID" value="VAB18032_10390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10390"/>
    <dbReference type="eggNOG" id="COG0689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050858_0_0_11"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="163"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="243" mass="25736" checksum="25DBF0BF1E9BEF92" modified="2011-06-28" version="1">MARPDGRQPDQLRPVTLTRGWSTHPEGSVLVEFGATRVLCTASVTEGVPRWRRGSGLGWVTAEYAMLPRATNTRSDRESVKGRVGGRTHEISRLIGRSLRAAIDLKALGENSIVLDCDVLQADGGTRTAAITGAYVALHDAVSWLAARKALTGTPEKVMHRSVAAISVGVVAGEPRLDLCYDEDVAAEVDMNVVCTGAGDFVEVQGTGEAGVFARDQLDALLDLATVGCLDLAEAQRKALGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7F8</accession>
    <name>F4F7F8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FkbH like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Phosphatase and glyceryl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">abyA2</name>
        <name evidence="3" type="ordered locus">VAB18032_16455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1401" last="1410">
            <title>Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.</title>
            <authorList>
                <person name="Gottardi E.M."/>
                <person name="Krawczyk J.M."/>
                <person name="von Suchodoletz H."/>
                <person name="Schadt S."/>
                <person name="Muhlenweg A."/>
                <person name="Uguru G.C."/>
                <person name="Pelzer S."/>
                <person name="Fiedler H.P."/>
                <person name="Bibb M.J."/>
                <person name="Stach J.E."/>
                <person name="Sussmuth R.D."/>
            </authorList>
            <dbReference type="PubMed" id="21656887"/>
            <dbReference type="DOI" id="10.1002/cbic.201100172"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF752342">
        <property type="protein sequence ID" value="AEK75498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733057.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16455"/>
    <dbReference type="EnsemblBacteria" id="AEB44397">
        <property type="protein sequence ID" value="AEB44397"/>
        <property type="gene ID" value="VAB18032_16455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16455"/>
    <dbReference type="eggNOG" id="COG3882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018095_1_0_11"/>
    <dbReference type="OMA" id="TTRRYND"/>
    <dbReference type="OrthoDB" id="1310135at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010037">
        <property type="entry name" value="FkbH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01686">
        <property type="entry name" value="FkbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="457"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEK75498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="622" mass="68048" checksum="9030569BD80627CA" modified="2011-06-28" version="1">MTAGAAAPSATGSDAAAELSELYRSGRLPTEFPRLRALLAELPDTELHRAGRLLERVGPDAVRAAHPDVPVVPITVSGYGTVAPLVPLLTVELARHGLLLDPRLGDFGGYLDALAAPDDSSLLLTLLDAQVVFDQVPTPWRPEDVAHTFTAKIDLIEGLLARSTTPVVLNTIPLPRIFPAQLIDHRSRALLGAVWREANARLLRLSQDHPTVVVVDLDPWAATGLAVRDARLSVYAKAHLTPPLLHAYAREVAHLARARAGAARKVLALDLDETVWGGVVGEVGPLAVEVADSHRGEAFREFQRVVRQLGSQGVLVAAVSKNDPEPVREALRAHPGMTLREDDFVRVVANWRPKHENLRTLAEDLNLGLDSVVFVDDSPFEQGLVRRELPEVAVVAVDDEPADHVGRLLADGWFDTVTLTAEDRQRPGLYRAEVERRDFLHSFDSLRDYLAELKVRVDLAVADETDVPRVSQLTLRTNQFNLTTRRLAPADVLALLRHPAATVLTVRCADRFGDIGLVGAVVLRHDDDVLHVDNFVLSCRAFSRGVETATLAEILRHARGSSASAVTAEYLPSRRNAKVADFYPRNGFTRLDATHFRHDLTDMPRPPEHVQLTGSWPPGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F844</accession>
    <name>F4F844_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Group 1 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10435"/>
    <dbReference type="EnsemblBacteria" id="AEB43205">
        <property type="protein sequence ID" value="AEB43205"/>
        <property type="gene ID" value="VAB18032_10435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10435"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_753664_0_0_11"/>
    <dbReference type="OMA" id="GRHINRT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="373" mass="41289" checksum="DAA6976832ED1789" modified="2011-06-28" version="1">MSAVEGRADDVHTWSGIPANVVRTMRDLDVDHVVLDEPSPLLVRSGKLVAAASKRAGHKLNWEVEPRLVRHLTRQIQAQARQANADLLLLLGWHTLGVEPGDVPAVIWTDATYAQRVERAPHWQHLSGRTRGQVEPVEGESLRQMAAVVMSSTVAYEDAAARYRVDPSRLHRIGFGANLTATQAGPRSRIGDPPRLLTVGVKWERKGVDRSVLIADELHRRGIPVHLDVVGVRPPDDSWRRDHVTYHGFLHQDREADRNRLQRLYADADLFLLPTRNEPFGIVFAEAAAYALPSLGSAVDGVPDVVQHDRSGILLPVDATAQQYADEIAALLAAPDRYADLSLGALTHYRSSLTWDSAVRRVLDVCEIAVKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F855</accession>
    <name>F4F855_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731887.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10490"/>
    <dbReference type="EnsemblBacteria" id="AEB43216">
        <property type="protein sequence ID" value="AEB43216"/>
        <property type="gene ID" value="VAB18032_10490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10490"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077728_2_1_11"/>
    <dbReference type="OMA" id="GYKEVGR"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="20293" checksum="715B38F8614F0036" modified="2011-06-28" version="1">MTLRFVLDPELTPHLRADIVALWVDVTNAGGAVGFVAPVTADKVRTIADPTLAGIADGPDRLLLGYDDDRLVAMAIFTDPRFHLKQHLRVLTRVMVHPDTQGRGVGDALMRKAAQVGRDLGLTALHVTVRDGLGLDRFYRRLGYREVGRWPGAIRVAPGDDRDEILMWLGLSEDSAKQTTSGPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F862</accession>
    <name>F4F862_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731894.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10525"/>
    <dbReference type="EnsemblBacteria" id="AEB43223">
        <property type="protein sequence ID" value="AEB43223"/>
        <property type="gene ID" value="VAB18032_10525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10525"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_3_11"/>
    <dbReference type="OMA" id="GTHDSWV"/>
    <dbReference type="OrthoDB" id="1678187at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="75"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="25519" checksum="46D73D6350F936AC" modified="2011-06-28" version="1">MSSRKGRKDAARVVREQLARERRRKRTLWVSIGAVAVLVVAGLIGWSVWSSQSSGTFVAPPGATEDGTGIVVGSGPVTIDVYEDYLCPACKQFEQTSGATIEQLVSDGKARVVYHPVAYLNRFSSTQYSTRASAASGCAAEGGKFTEFSKALFDKQPPENGAQLSDNELIDIGAEVGLNRDSFGSCVRDGKYKPWTSHVSEEATRANVTGTPTVLVNGEQVREWTPENITAAVEAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F865</accession>
    <name>F4F865_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Copper resistance protein CopC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_10540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10540"/>
    <dbReference type="EnsemblBacteria" id="AEB43226">
        <property type="protein sequence ID" value="AEB43226"/>
        <property type="gene ID" value="VAB18032_10540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10540"/>
    <dbReference type="eggNOG" id="COG1276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023176_0_0_11"/>
    <dbReference type="OMA" id="MYKGNAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309156" evidence="9">
        <location>
            <begin position="36"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="10">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="11">
        <location>
            <begin position="330"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="551" mass="56974" checksum="26CE2AC5B58E3F78" modified="2011-06-28" version="1">MTAAPRRRFARLTAAAGLLVTVVALLLAPASPAAAHAVLSSSSPAASSVVPNAPTEVVLTFSEPVRKVPDKIRVIAPDGSRVDRGEPTFADSVVSIPVDNSAGNGTYLVTYRVISADSHPVSGAFTFSVGAPSEPPVDAGNDSRADPVVSNAVKVSKFVGYAGLLLLVGATLVLALLWPRRLPRTAPARLAWIGLGLVALATVATTLLQVPYTNGGGPFDITGAGLGLVLGSTFGAAHLVRLGLLAAAAVLLRPLFAGSVGRTDLIILGVLGGAALLTWPLAGHPAASPAPAVSVLVDAVHLGSMAVWLGGLVMLVVFLLPRADERELGAILPIWSRWAALAVSALLLAGIVQALIEVATPTALVNTTYGRLVLAKVGLFALVIAVAAYSRHLVRKRIAASRPAPMRRAVWVELAVTAVVLAVTSVLVQTPPARTAGADVAGAESGYFTTTVQSSLYSMQIEMAPAQRGNNSVHFYAYTLDNQPLPIKEWKATVALPSAGIEAIDVPLLPLTDNHATGEINLPSAGEWELRVTARTTEIDQATVTATVSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F869</accession>
    <name>F4F869_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligoribonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10560"/>
    <dbReference type="EnsemblBacteria" id="AEB43230">
        <property type="protein sequence ID" value="AEB43230"/>
        <property type="gene ID" value="VAB18032_10560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10560"/>
    <dbReference type="eggNOG" id="COG1949">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064761_3_0_11"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="20508" checksum="A9EF948DDA749EDD" modified="2011-06-28" version="1">MTGLDLGSDKLIEVAALVTDPDLNVLGDGVDVVIHADDAALDAMPEIVRTMHGKSGLTEEVRRSTVTLAEAEDMVLDYVSRHVKDPRTAPLCGNSIATDRGFIARDMPRLDAHLHYRMIDVSSIKELCRRWYPRVYFGQPQKGLAHRALADIRESIRELEYYRRTIFVPLPGPDVDTAKGIAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8C7</accession>
    <name>F4F8C7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16840"/>
    <dbReference type="EnsemblBacteria" id="AEB44472">
        <property type="protein sequence ID" value="AEB44472"/>
        <property type="gene ID" value="VAB18032_16840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16840"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="OMA" id="MQYVTAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="6"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="33269" checksum="FF812A7EFF0E8B6F" modified="2011-06-28" version="1">MFDETGGPDVLRVVDEPVIEPAAGEVRVRIEAFAVNPLDQMVRAGQSPRPVQLPHARLGVEGTGVIDALGSGVTGLAVGDPVILGAVPDFETRGAYAEYTTLLADRVVPRPAGLEPVGAAALWVSYFTAYGALVDRAGMRPGDQVLITAASGGVGRAAIQIARQIGAVPIAVTRQSARVQSLLAAGAAAVIATDREDIGEATRRHTGGVGADIILDAVMGPGLAELSLAAKLGGTLATVGWLDPRPASFPANPSLTIHRYMSFADMVDPQTARRVAAFLAAGVRTGVLQPTVDRVFPLDDIIEAHRYLEKGTPAGKIVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8F6</accession>
    <name>F4F8F6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GltA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16985"/>
    <dbReference type="EnsemblBacteria" id="AEB44501">
        <property type="protein sequence ID" value="AEB44501"/>
        <property type="gene ID" value="VAB18032_16985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16985"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085736_0_0_11"/>
    <dbReference type="OMA" id="LLYRKWP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="283" mass="31830" checksum="B6D2C066BC1CC525" modified="2011-06-28" version="1">MISVITPVLPAHVDMLAQAHESLLSQDSGPDWEWLIQIDGTPDGPVDETFPAAATDGRIRVAANGERLGVSATRNRALLRSTGRWVAPLDADDEFFPNTLALLSEPLRTRPEVSFVFGESVDVFPDGKRLARFTRRPYEPGSVPPGRLEDIWRHHKNLFFHPGAVMFDRTWLLAAGGWPAGTEMEDQDVLLAISTFASGWYVPHPVHLYRQHRDQTVRTARFESNRESYRRWSHTRLVALRTLRGDDPDELRMLETPLPSPEEISTFTTAEWQAEIAGQVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8G3</accession>
    <name>F4F8G3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_17020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17020"/>
    <dbReference type="EnsemblBacteria" id="AEB44508">
        <property type="protein sequence ID" value="AEB44508"/>
        <property type="gene ID" value="VAB18032_17020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17020"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012609_0_0_11"/>
    <dbReference type="OMA" id="HAILTHD"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="746" mass="80125" checksum="4DA5EF3FCFE6DE64" modified="2011-06-28" version="1">MMFRVLGPLEVLIDSRPIRLGGIKQRATLGFLLLKANQVVPTSQLLSALWPDKDPPASARKVLQNAVWSLRAALSVTKGTDMLRLSTQAPGYILQVDPAYVDLFRFHQLAERGRDEKAQPDRAAAILREALATWRGTALSDLVENGISWPELAAVENARLDTQQDWFDAELACGRHQSVLGELKAMVEAHPLRERACGQLMLALYRCGRHADALAVYSGLRTSLVEDLGLEPGPALQKLQHAILTHDPSLTLDPATVPAPARDVAVMRPPRPIPPIPAPRAPSDPRRAHLTLAMVRVRTCADATDPVRVDYELAAATRMVRSGIEELGGTVATSIGSATLALFGRPPTRGGDEERAVRAALTLRDCFADGMGRGLVMQVAVATGETLVLTEPNSRLTVSGALVDRCHQMLSAVPEGTVWVCPRTRELIGDGFDALPAAEGAWEIRGVGGHDPERDSDLALIHGLLERALRRNTPHLVTVLGDSDDLLDRLTGLVNGPRVLDGRTASDDPLRAAAELVTELCAVAPEDTPEVIRDRLRTILGADGPAESVVSALLPLLCPEHSTQPGTLAAWQLLLEQAARAQPLVVLLRDLHLAGDDLLDAVEELADLNAPLPLVVVAAARSALLKRRPSWGGGKPHAACITLDPPQSGTINRLRHLMASASIGGRCDGELPDQRRRSAPLTPPWDLGRPEPRLAALDVPPLTHGIRLSTPDSADTLCRAVFEDVADDTLALASTVRLDGPCPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8J6</accession>
    <name>F4F8J6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44541">
        <property type="protein sequence ID" value="AEB44541"/>
        <property type="gene ID" value="VAB18032_17185"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17185"/>
    <dbReference type="eggNOG" id="ENOG5031CVH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062995_1_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="187" mass="21342" checksum="780443A700D27BE3" modified="2011-06-28" version="1">MLPGAEILSDRRLVLDRPSELPAHLLQAGAGRRIIMHGMHSVVDWCCFALWENGKLVRSLSLSPDGGIEENIGEPFDFERPYWDGEHPVEPVPGWSEYPYPLPFHPLDLGEEALRVLFGFVLEGRPEPDDILAETVHTHEFRVADPSGEEQTAREAAYEQVRRDIGPLRMFRMGPDGTMREVDWDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8S0</accession>
    <name>F4F8S0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23575"/>
    <dbReference type="EnsemblBacteria" id="AEB45813">
        <property type="protein sequence ID" value="AEB45813"/>
        <property type="gene ID" value="VAB18032_23575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23575"/>
    <dbReference type="eggNOG" id="ENOG5033C8E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119179_0_0_11"/>
    <dbReference type="OMA" id="AGHCRAY"/>
    <dbReference type="OrthoDB" id="2098830at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="297" mass="30255" checksum="6BC6CA4C1C110A86" modified="2011-06-28" version="1">MYLRRLDGTGVPTDHDHLLDAAREPRPTAAPSGSPDPLAGLLRAAAAPPRPGELAGEEEALAAFRAARQAGLTPPVSRPTRRRRFTAGVVVWIAGVAATATAGAALAAVRLDWPHERSAPPSTPITRPVAPSPSAAGGQPDRGGVTPSQDGPGAAPTATGGVTPGVSVEPTAGAPDPTSAPPTSEPPQSREPTVERTVQAGPGNSDNTADRPGLCKAYLSKSERQREKALRTPAFSELVVAAGGADNVLAYCQAVLAETDPEWLAKHGPAAGSAARSIDPAGLFPGRYAEEFPLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8V5</accession>
    <name>F4F8V5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cellulose-binding family II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_29821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735683.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29821"/>
    <dbReference type="EnsemblBacteria" id="AEB47035">
        <property type="protein sequence ID" value="AEB47035"/>
        <property type="gene ID" value="VAB18032_29821"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29821"/>
    <dbReference type="eggNOG" id="COG3469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019399_1_1_11"/>
    <dbReference type="OMA" id="CIQLEAG"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307738" evidence="8">
        <location>
            <begin position="31"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="9">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="173"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB47035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="467" mass="48343" checksum="0B73E5292E7624BB" modified="2011-06-28" version="1">MKRSRALVLSVVGALAAALGAVWLAPAAYAASVTASFVKTSDWGTGWEGKYTITNGGTATVNGWNLGFDLPAGTTVGTYWDALLTSSGQRYTFTNRSWNGTIAPGASVSFGFLGSGSGVPSNCRLNGAACAGGTTPTTPPPTTPPPTTPPPTTPPPTTPPPTSPPPVTGLPKHILTGYWHNFDNPAVELRLRDVPAEYDLVAVAFADATGTPGAVGFAIDPGLSASLGGYTDADFSADVRTLQSRGKKVIISVGGETGRVVVNSSASAVAFADSVYALIQRYGFDGVDIDLENGLDPTYMAQALRSLRAKVGSSLIIAMAPQTIDMQNPATSYFKLALDIRDILTVVNTQFYNSGAMLGCDNNAAYAQGTVNFIVALACIQLEAGLRPDQVGLGLPAGPGAAGGGIVTPSVVNAALDCLTRGTNCGSFRPPRTYPALRGAMTWSINWDVTHNTSFARTVSPHLRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Y5</accession>
    <name>F4F8Y5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="6 15">2.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Phosphotransacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">VAB18032_29971</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in acetate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + phosphate = acetyl phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19521"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">In the N-terminal section; belongs to the CobB/CobQ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="6 15"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29971"/>
    <dbReference type="EnsemblBacteria" id="AEB47065">
        <property type="protein sequence ID" value="AEB47065"/>
        <property type="gene ID" value="VAB18032_29971"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29971"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019723_3_3_11"/>
    <dbReference type="OMA" id="FFMCLAD"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016475">
        <property type="entry name" value="P-Actrans_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006107">
        <property type="entry name" value="PhpActrans_proteobac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="S5A_REDUCTASE" evidence="16">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR006107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB47065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="689" mass="72512" checksum="29ACAA04995EE17D" modified="2011-06-28" version="1">MYLTSVGSGGGKSTIALGLAELLSRQVGQIGVFRPLVASDRPDPILALLSERYRVGLPVADLSGTTYAEATALVADGRREELITRIVERYRDVERRFPAMVVVGSDFADAGDGAGPRELAFNARLATEFGSVVVPVVDGFGQQPAAITAASRGAYHDVVDLGATVLAVLANRVPGSMRLPRLPVPAYAIPEVPSVSAPTVAEVAAALGATRLAGDDTALARDVLDYVVGAAHVPTVLEHLTEGALLIMPGDRDDLLVAASAAHVAGQVSLAGLVLTLGVAPDPRAMQLVEALNARLAVLSVPTDSFHTVAASSRIEGRPSAANPRKVEAALGAFEAHVDTTELASRLRVSRSTRVTPLMFEYDLIDRARSRRRHVVLPEGTDERILRATEILLRRGVADLTLLGRPDEVARRAREVGVDIGTARVVDPADSQWRDEFAEAYAKLRAHRGVTVELAYDIVAQPNYFGTMMVWAGYADGMVSGATHTTAATIRPAFEIVKTMPEVSVASSVFFMLLADRVLVYGDCAVNRDPDAAQLADIAISSADTAARFGLEPRVAMLSYSTGSSGAGADVEKVAEATALVRERRPDLAVEGPIQYDAAIDPAVAATKLPESTVAGRATVFIFPDLNTGNNTYKAVQRSAGAVAVGPVMQGLRRPVNDLSRGATVPDIVNTVAITAIQAATLTDNGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Z7</accession>
    <name>F4F8Z7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ordered locus">VAB18032_30031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007072794.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30031"/>
    <dbReference type="EnsemblBacteria" id="AEB47077">
        <property type="protein sequence ID" value="AEB47077"/>
        <property type="gene ID" value="VAB18032_30031"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30031"/>
    <dbReference type="eggNOG" id="ENOG5032RSG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106245_6_2_11"/>
    <dbReference type="OMA" id="DTCLKWA"/>
    <dbReference type="OrthoDB" id="1944871at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
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    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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        </ligand>
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        <location>
            <position position="40"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="85" mass="9520" checksum="38DF3F8CCCE7821C" modified="2011-06-28" version="1">MDWRHHAVCRDEDPELFFPIGTSGPALLQVEQAKAVCRRCSVTDQCLQWALESGQDAGVWGGMSEEERRAVKRRGGLRVLRAHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F910</accession>
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        </submittedName>
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        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42038.1"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0051301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
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        <location>
            <begin position="236"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="261"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AEB42038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="542" mass="60543" checksum="4FF8C3CF1D499187" modified="2011-06-28" version="1">MNFRRFQITAPWPLVWTVTGLFLLLRSIVAVVRLAVFAVRHWRAWPLVALVLLAIDGYRSHGWWPHLLVLLVAAAGGGVWWWKGRESFHHLVALRAVTVWRRLWVYRRQWHEVMSLCGLVKKYDGGEVVPRLLSVRCSYATDELVVRMPKGQNPEVYHKAARDLAYSFGTRHCRVFSGRRQAPPARTGRLAWLLRLVDRVRFRDRPRHVWLVFIRRDPLTRVVAPLPVPARPDFTALPLGVREDLAVYCLRLLATHVLIGGATRMGKGSVIWSLLRSLAAGIRSGLVRVWAIDPKGGMELSIGRALFSRYVDDDWTRMADLLDDAVARMRARQQALRGKVRVHTPSVDEPLIVVVIDEIAALLAFLPDSDIRHRITQALGLLLTQGAGLGVLVVAATQDPRKEVVSVRDFFPTRIALGLTERAHVDLLLGDGARDRGALADQIPTSAKGVAYVLLDGQPEPARVRFSYLPDDVIRDMAATFPAPPETQPEPIDVPAPAKPVRSSGNGRHVYRPTPPKQAAPLLPPSLLNALDLNTTNGSDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F960</accession>
    <name>F4F960_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730762.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04810"/>
    <dbReference type="EnsemblBacteria" id="AEB42088">
        <property type="protein sequence ID" value="AEB42088"/>
        <property type="gene ID" value="VAB18032_04810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04810"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131367_0_0_11"/>
    <dbReference type="OMA" id="GQWIVED"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="162" mass="17327" checksum="74163BB3F8AFA01C" modified="2011-06-28" version="1">MPELVITVARFGFLVLLWIFVFTVVGVIRRDLFAGARSGRLVAAPRTVGASTGQATAKPAKVKRGRAAHQLVVTAGQLAGTRITLGEAQITIGRAEDSTLVITDDYASARHARLVPRDGQWFVEDLGSTNGTYLDRAKVTGPTPVPLGVPIRIGRTSLELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9Z9</accession>
    <name>F4F9Z9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00130"/>
    <dbReference type="EnsemblBacteria" id="AEB47110">
        <property type="protein sequence ID" value="AEB47110"/>
        <property type="gene ID" value="VAB18032_00130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00130"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042635_0_0_11"/>
    <dbReference type="OMA" id="SGTPHLY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="352" mass="36699" checksum="76675817DD8BA0C5" modified="2011-06-28" version="1">MPGLSRLWRDRHTLQLGLDQERAVLVEIADPRTAGLLDLLDGTHSERQVLTGAGARTEYARTLLDALRTAGLVVPLHTLVPRELTGPRRARLVTEAAALALAAARLPGTPAQVLRRRLASRVTVTGVGPLGAAIAVALAQAGVGHVHPDLPGCVRPIDLVGTGITAGEIGRPLGRAVQAAVARSAPGTGTSALRRPRPDLVIQLGADRPAPLLAAGHAQRRQPHLMVDLREGVPVIGPLVRPPDGPCLGCLDLHRTDRDPDWPALAAQLASRPAAPSCAASILLAATALAVGEALHQLDGGTPETLGAAIEIASPGNLRRRHWPPHPRCGCSRTRTSGGQPGRTAATRVQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA28</accession>
    <name>F4FA28_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735785.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00275"/>
    <dbReference type="EnsemblBacteria" id="AEB47139">
        <property type="protein sequence ID" value="AEB47139"/>
        <property type="gene ID" value="VAB18032_00275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00275"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_1_0_11"/>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="34806" checksum="9E5C7BA06DADD4C1" modified="2011-06-28" version="1">MVVRAGARLRAAVLGTGLIGGSVLLRLHAAGLDVIGWDPDEATRGQARALGVPTADLLADAVADRDVVFLGGPLPTLPATLVEVAGLTGEDCLLTDVGSTKAELAAFAAAQGLTHRFVPGHPMAGTDRAGLSAAVPDLFAGAAWVLCPAWDGLAAFRRLTALITEVFAARVVPMAADRHDRVVAFASHVPHLLAGALAGAAERSALRDAVLTLAAGSFRDGTRVAGTPPQRTTNMLRGNRAEVLAALAEVTGYLDELSRALRDDEPELLTARYAEAAAARAALTDRPHAEQDLSFPLAGAPADEVAWLGELGAAGGHLSDCRVGGDVVSYRAHLPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA49</accession>
    <name>F4FA49_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735805.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00380"/>
    <dbReference type="EnsemblBacteria" id="AEB47160">
        <property type="protein sequence ID" value="AEB47160"/>
        <property type="gene ID" value="VAB18032_00380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00380"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_4_0_11"/>
    <dbReference type="OMA" id="NALMHLY"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="26870" checksum="4BB092FDB175FCDD" modified="2011-06-28" version="1">MSVFDDPGHFGRLWADTYDLPSGLPDPALAVEFLAEKSGGGRVLELAIGTGRVALPLAARGVTVEGVEASPEMVAKLRAKPGGADLPVAIGDMADVPVNGPYAMAYLIFNTLFNLVREQRQADCFRNVARVLAPGGAFVVETYVPNAADFDRDEQVQPYSITEDSVRIRLHRYDRAAQTFLRQTVTFNNAGVHLHPFAMRYMWPEQIDEMAGRAGFHLAERYADWDRTPFGPDSTSHISVYRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA94</accession>
    <name>F4FA94_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730829.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05145"/>
    <dbReference type="EnsemblBacteria" id="AEB42155">
        <property type="protein sequence ID" value="AEB42155"/>
        <property type="gene ID" value="VAB18032_05145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05145"/>
    <dbReference type="eggNOG" id="COG2035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055621_0_0_11"/>
    <dbReference type="OMA" id="PIPVWSF"/>
    <dbReference type="OrthoDB" id="1426624at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="33204" checksum="3248A2D9E10C7549" modified="2011-06-28" version="1">MAFGERLGHGVRGAAIGVAEAVPGISGGTIALVTGVYERVIASAGHVVSAIRYAASDLPRGRGGIRARQQLRQVHWEVVVPLLIGMLPGLLIAAKTLEPLLTDYPEQTRGLFLGLVLASVLVPVSMVGAPWRRKEIAALVLAAVGAFALTGLPQATLDPHPLIVLMAAAIAVCALVMPGVSGSFLLLTVGLYEPTITALNDRDFGYLAIFATGMVIGLSLFVKLLQWLLEEHRRMTLAVMSGALLGSLRALWPWQSDERTLHAPGDNILPITALFLVGIAVVTAMVVAERRRLRRAAQDLTEEAYETPQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA98</accession>
    <name>F4FA98_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05165"/>
    <dbReference type="EnsemblBacteria" id="AEB42159">
        <property type="protein sequence ID" value="AEB42159"/>
        <property type="gene ID" value="VAB18032_05165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05165"/>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120441_0_0_11"/>
    <dbReference type="OMA" id="TLGLFHI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="148" mass="16098" checksum="619DF6EDB77D07AF" modified="2011-06-28" version="1">MTAGQSAEPTRRWPPRCQDVVVGFLIRLATTAVALWVTTLIVPGVEVTGRSGYDTAFTLLIVALIFGVINAVLKPLIKVVGCVFYLVTLGLFALVVNALLFLLTDWVAGVLKLPFHVNGFWAAFWGAIVMAVVTWLISVIVPDSTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAK4</accession>
    <name>F4FAK4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ordered locus">VAB18032_11585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732101.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11585"/>
    <dbReference type="EnsemblBacteria" id="AEB43431">
        <property type="protein sequence ID" value="AEB43431"/>
        <property type="gene ID" value="VAB18032_11585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11585"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_3_0_11"/>
    <dbReference type="OMA" id="AVKMDKR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="77" mass="8509" checksum="D2388EC08349CEB6" modified="2011-06-28" version="1">MALRPALEHLVKGIVDHPDDVRVRMVDSRRGKRLEVRVHPEDLGTVIGRSGRTAKALRQVIGSIGGRGVRVDIVDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAQ8</accession>
    <name>F4FAQ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733328.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17855"/>
    <dbReference type="EnsemblBacteria" id="AEB44673">
        <property type="protein sequence ID" value="AEB44673"/>
        <property type="gene ID" value="VAB18032_17855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17855"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_11"/>
    <dbReference type="OrthoDB" id="1015470at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="432"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="521" mass="54173" checksum="151BEB54B3A4755E" modified="2011-06-28" version="1">MAPLALDAVLLDAAARHPDRPLYAFAELDRPVTYAEFAELAGRGAAVLAAHGIGRGDRIAVWSENSLAWLTLLAAAAWRGAALVTLHPGLTGAELAEAVARARPRRLFVAGRIRDRDAVAEANAALTGAPYAPDGIHLLGDDGGRQALAGLPGWADPTPEPVGDADAVLNIQFTSGSTGPAKMVTLSGRNLVRNAQWTAQAAGLHAGDVLASPLPLAHAAGLSSGAVLALVTGALWVSTRRFRSETVLDLIERHRCTVLQAVPTMATMIADRVQAEPRRWDISSLRVGFLGGAPCPPALRERTVRVLGLDRAAVIYGQTEAGPTISVDPGDGSCAPVGLTVGRIVPDLDAVVVQPGTRHPVPSGEAGELLVRGESVTSGYLDDPAATAAALTDDGWLRTGDLGALSSERVFTLTGRVKELIIRGGENVSPAEVEAVLCEHDTVGQACVLGVPSARWGEEVGALLIAAPGARLDIDDVLAAVAGRLARHKLPTRVRVVADLPLLPSGKVDRRAALTLFEGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAU0</accession>
    <name>F4FAU0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxaC</name>
        <name evidence="7" type="ordered locus">VAB18032_24025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734555.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24025"/>
    <dbReference type="EnsemblBacteria" id="AEB45903">
        <property type="protein sequence ID" value="AEB45903"/>
        <property type="gene ID" value="VAB18032_24025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24025"/>
    <dbReference type="eggNOG" id="COG1904">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044465_0_0_11"/>
    <dbReference type="OMA" id="IWHQCNE"/>
    <dbReference type="OrthoDB" id="167900at2"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="476" mass="52773" checksum="FB594C48E9A5FC7C" modified="2011-06-28" version="1">MPTSTRPDLLLPADPGQRALARELYALVARLPIISPHGHVDPALLAEDQPFGDPAQLLIVPDHYLTRMLLSQGVPPSELGVPSRDGTPVETDGRRIWRRFAEHWHLFRGTPSRLWLEQTFTEVFGVDTRLSPATADEVYDALAAKLAEPDFRPRALFERFNIEVLATTESPLDDLGRHAKLAADGWGGPGGRVVTTFRPDNVVDLEFEDWSANVDRLGEITGEDTGTYAGYLAALRARRAAFIDAGATSSDHGHRTARTLDLGADAATLFDRARRGRAEPGDAEAFAAHMLLEFARMSLDDGLVMQLHPGAVRNHNRWLYARHGRDVGGDIPQVTEYVHALAPLLDAYGNDPRLRVVLYTLDEDTFTRELAPLAGGYAALLLGAPWWFLDSPEVLRRFRETVTETAGFYNTAGFVDDTRAFCSIPVRHDVARRIDAGFLARLVAEHRLPMDEAAETIVDLAYRLPKQVYKFGEGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB40</accession>
    <name>F4FB40_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735830.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00505"/>
    <dbReference type="EnsemblBacteria" id="AEB47185">
        <property type="protein sequence ID" value="AEB47185"/>
        <property type="gene ID" value="VAB18032_00505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00505"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="THHPGRK"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="345" mass="37688" checksum="2ACF0FE7498B1EAA" modified="2011-06-28" version="1">MSTPTSPPTPASPTPPGGHLLEIRDLHIEFRTGEGVAKVINGVSYHLDPGETLAVLGESGSGKSVTAQAIMGILDTPPAHISSGQIRYQGRDLLELPEEQRRQVRGKEIAMIFQDALSALNPVFPVGWQIGETLRQRLGMSRVDARRRAVQLMELVQIPGAASRLDDYPHQFSGGMRQRVMIAMALAMEPKVLIADEPTTALDVTVQAQIMDLLADLRRDLNMALILITHDLGVVADVADRIAVMYAGRIVEHADVRSLYRAPAHPYTKGLLESIPRLDQRGGKLSTIRGLPPNLMRIPSGCPFHPRCPYVQQVCVDVVPHDLVLGDGRTSACHFAQEVHDDRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBK9</accession>
    <name>F4FBK9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-oxoadipyl-CoA thiolase</fullName>
            <ecNumber evidence="4">2.3.1.174</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_11785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:19481"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57348"/>
            <dbReference type="EC" id="2.3.1.174"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732140.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11785"/>
    <dbReference type="EnsemblBacteria" id="AEB43471">
        <property type="protein sequence ID" value="AEB43471"/>
        <property type="gene ID" value="VAB18032_11785"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11785"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_11"/>
    <dbReference type="OMA" id="NASPMND"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012793">
        <property type="entry name" value="PcaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02430">
        <property type="entry name" value="pcaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="9">
        <location>
            <begin position="275"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="400" mass="41770" checksum="C17D57A118A3743C" modified="2011-06-28" version="1">MTVAYLVAGVRTPIGRYAGALAGVRPDDLAAHVIRELVARHPSVDWSRTDDVVFGCANQAGEDNRNVARMAALLGGLPEQVSGSTVNRLCGSGLDALATAARAIVAGEADLMVAGGVESMSRAPFVMPKATSAFSRAAEMYDTTIGWRLVNPLMEQGWGVDSMPETAENVAVEFGVDRLAQDEFAYRSQMRAAKAQADGRLAEEIVPVTVPAGRRETRLVEVDEHPRQTSMEKLGALPTPFRTGGTVTAGNSSGVNDGAVALLVASQRAVEEYGLTPLARVVGTATAGVPPRIMGIGPVPATRRLLQRQGLSVTDLDVIELNEAFAAQSVAVLRELGLPEDAEHVNPNGGAIALGHPLGASGARLALTAALELRRRGGRRAVATMCVGVGQGISMLLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBP8</accession>
    <name>F4FBP8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11980"/>
    <dbReference type="EnsemblBacteria" id="AEB43510">
        <property type="protein sequence ID" value="AEB43510"/>
        <property type="gene ID" value="VAB18032_11980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11980"/>
    <dbReference type="eggNOG" id="ENOG5031SDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205103_0_0_11"/>
    <dbReference type="OMA" id="CAYVMRY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046177">
        <property type="entry name" value="DUF6186"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19684">
        <property type="entry name" value="DUF6186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7808" checksum="F331BBAECFA69620" modified="2011-06-28" version="1">MRAVAIGGFLLGLALFGLVEWLARREGSRIPTLGEVCAYVMRYEVGPVPVGRIGLFGFWWWVGWHFLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBU8</accession>
    <name>F4FBU8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733403.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18230"/>
    <dbReference type="EnsemblBacteria" id="AEB44748">
        <property type="protein sequence ID" value="AEB44748"/>
        <property type="gene ID" value="VAB18032_18230"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18230"/>
    <dbReference type="eggNOG" id="COG3254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100689_3_0_11"/>
    <dbReference type="OMA" id="KRHDEIW"/>
    <dbReference type="OrthoDB" id="1694303at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="107" mass="12231" checksum="2C52F71954211C80" modified="2011-06-28" version="1">MCYLYRLRPGAEAEYERRHAALWPEMAALLDEAGMYDYHIYRHGLLLICVLRTRWGFDHARRVTGASPVQARWSASLAHLFAEIADADGEPLWAYPVFHHPGRPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC29</accession>
    <name>F4FC29_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734679.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46027">
        <property type="protein sequence ID" value="AEB46027"/>
        <property type="gene ID" value="VAB18032_24645"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24645"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178398_0_0_11"/>
    <dbReference type="OMA" id="VIRYTTR"/>
    <dbReference type="OrthoDB" id="2027025at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="11129" checksum="85FDE797A27D0122" modified="2011-06-28" version="1">MRQTTVIRYTTRPEVADENAKLVEDVFAELAQTRPAGLHYATFRLGDGTEFMHVLVAEEGSTALTDTAAFQRFQEGIRSRCAAPPQFEQATVVGSYGFGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCB3</accession>
    <name>F4FCB3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ordered locus">VAB18032_01040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007073013.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="SMR" id="F4FCB3"/>
    <dbReference type="STRING" id="263358.VAB18032_01040"/>
    <dbReference type="EnsemblBacteria" id="AEB47292">
        <property type="protein sequence ID" value="AEB47292"/>
        <property type="gene ID" value="VAB18032_01040"/>
    </dbReference>
    <dbReference type="GeneID" id="5704894"/>
    <dbReference type="GeneID" id="67457610"/>
    <dbReference type="KEGG" id="vma:VAB18032_01040"/>
    <dbReference type="PATRIC" id="fig|391037.6.peg.4332"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_11"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="73" mass="8485" checksum="E4861C9BCB9D1E59" modified="2011-06-28" version="1">MPKKDGAIEIEGRVIEPLPNAMFRVELANGHKVLAHISGKMRQHYIRILPEDRVVVELSPYDLTRGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCJ7</accession>
    <name>F4FCJ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730997.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05990"/>
    <dbReference type="EnsemblBacteria" id="AEB42324">
        <property type="protein sequence ID" value="AEB42324"/>
        <property type="gene ID" value="VAB18032_05990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05990"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_8_11"/>
    <dbReference type="OMA" id="WQGINLE"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313792" evidence="1">
        <location>
            <begin position="25"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="57"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="311" mass="32635" checksum="5BB362E0A9D686BE" modified="2011-06-28" version="1">MFRRTPRILAATLAVAALALGACAEKTTETPTASGSPAGGAFPVTVGSLTLEQRPEKIISLAPTATEMLFAVGAGPQVVAVDDQSNHPADAPKTDLSGYQPNAEAIAAKNPDLVVLSDDRNKIVDQLAALKIPVYLTPAAQTLDDTYQQITDLGVLTGNATAGADVVQRMKDDIAKIVAEVPQRVQAPTYFHELGPELYTVTSKTFIGSIYSLAGLENIADAADADGKSGGYPQLSQEMIVAANPDFVFLSDVKCCQQSAATVSARSGWAGINAVREGQIVELDDDVASRWGPRVVDLLRAIVDATTKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCK4</accession>
    <name>F4FCK4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_06035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731004.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06035"/>
    <dbReference type="EnsemblBacteria" id="AEB42331">
        <property type="protein sequence ID" value="AEB42331"/>
        <property type="gene ID" value="VAB18032_06035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06035"/>
    <dbReference type="eggNOG" id="COG3973">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010312_3_0_11"/>
    <dbReference type="OMA" id="KHDARMA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="264"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="285"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="800" mass="84865" checksum="DB340334AA0FB19D" modified="2011-06-28" version="1">MSLHAQQLPQPTPHRPPTLDDELAAERAHLSDSRAALARMRERAEALFATGDKVAGDRYTAEQLGRHLARRVAELADDPRTPLFFGRLDFGSTDIPATSNTPATSNTATSDVATTTDTAATTGLDLTATADTGATADTAPTNTAGAAATTGIEDGDYTEQAASAGYGEHAGRRYHVGRRHVTDEQGEPLVLDWRAPVSRAFYQASARDPQGLAVRRRFGFDNGMLTSFEDEHLDRGEELGTASRILTAEIERPRVGPMRDIVATIQPEQDELVRADLAQSICVQGAPGTGKTAVGLHRAAYLLYLHRERLRRSKVLVVGPNRAFLAYIAAVLPALGEVEVEQATVEDLVDRVVVRAVDPPAVAVIKHDARMAEVLRRAVDAYVGEPTEPIVVSDGSFRWRIGLEPLHRLVQETRAEQLPYALGRERVRARVVALLQRQAEARRAESPSEAWLRRMGRSKPVTTFLDTVWPALTPDGLVHALLADPARLAAAADGLLTPAEQALLTGQDTTRTTTDAPSGTPEATAPEGSGTPASSGGAPGSSRPRSGTKLGRTPKATRWSAADAVLIDEAAGLIERPGSYGHVVVDEAQDLSAMQCRVIARRSEHGSLTLLGDLAQATAPWAATDWRVTLRHLGKPDATVVPLTVGFRVPADVLAFANRLLPLLAVDVPPAESLRRDGVLTVRTVTDLVGAAVAEVGAALAHEGSVAVIAAADAVDRLVAALAAAGIETATAADAGGGPRVTVVPATEVKGLEYDHVVVVEPADIVAAEPRGLHRLYVVLTRAVSRMSVLHRAPLPAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCM4</accession>
    <name>F4FCM4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ordered locus">VAB18032_12020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12020"/>
    <dbReference type="EnsemblBacteria" id="AEB43518">
        <property type="protein sequence ID" value="AEB43518"/>
        <property type="gene ID" value="VAB18032_12020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12020"/>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_0_1_11"/>
    <dbReference type="OMA" id="HHPNKAD"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="112"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB43518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="25788" checksum="62665091FDD38821" modified="2011-06-28" version="1">MGGPIRVGVLGARGRMGAEVCKAVDAAADTTLVAAVDQGDELAAVADAGAQVVVDFTTPGVVMDNLRWCIEQGIHAVVGTTGFTEQRLDQVRDWLAGKPGVGVVIAPNFGIGAVLMMQFAARAARHFESVEIIEQHHPRKLDAPSGTATHTARLIAAARAEAGLGPVPDATADEVAGARGADIDGVRVHAVRATGLVAHQEVLFGTTGETLTIRHDSYDRVSFMPGVLVAVRAVGNRPGLTVGLDPLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCM9</accession>
    <name>F4FCM9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12045"/>
    <dbReference type="EnsemblBacteria" id="AEB43523">
        <property type="protein sequence ID" value="AEB43523"/>
        <property type="gene ID" value="VAB18032_12045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12045"/>
    <dbReference type="eggNOG" id="ENOG5033408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098258_0_0_11"/>
    <dbReference type="OMA" id="NLPFGGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="16591" checksum="A4E74B1B41E61361" modified="2011-06-28" version="1">MVESDRLSRFVARVHARTPRWVVPLAALGCVGAGIGYTLISDPTRSAPDALPSCLLKLTTGLDCPGCGGTRALWYVLHADLPAAARHHFLFVFALPFLAYFFIAWAGKQAFGWRLPELRVGPKAVGVFLAAWLAFSVARNLPWYPFTTLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCP2</accession>
    <name>F4FCP2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cina domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12110"/>
    <dbReference type="EnsemblBacteria" id="AEB43536">
        <property type="protein sequence ID" value="AEB43536"/>
        <property type="gene ID" value="VAB18032_12110"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12110"/>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_1_0_11"/>
    <dbReference type="OMA" id="VEHALNM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="17619" checksum="658E112C67B9C185" modified="2011-06-28" version="1">MGRAAAGVVHRLTERRETLATVESLTGGLLAATIVEIAGASAVYRGGLVVYATELKEWLAGVPAQLLAERGPVDADVAAALAEGGRQRCGADWGLATTGVAGPEPQDGKPVGLVFVAVAGPDGTEVRELHLDGGRDQIRGASVTEALRLLTEHAQLSEGVTAAAGGGGRGGYAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCQ0</accession>
    <name>F4FCQ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12150"/>
    <dbReference type="EnsemblBacteria" id="AEB43544">
        <property type="protein sequence ID" value="AEB43544"/>
        <property type="gene ID" value="VAB18032_12150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12150"/>
    <dbReference type="eggNOG" id="COG1912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_1_0_11"/>
    <dbReference type="OMA" id="EIPYQKA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="28355" checksum="1E490037653C0EF1" modified="2011-06-28" version="1">MTSRTRTTGSAEVVSLTTDYGLADGFVAACHGVIARLAPTVRVIDVTHLVPPGDVRRGAAVLAQTVPHLPVGVHVAVVDPGVGTARRGIALATPEGLLVGPDNGLLLDAAAALGGVTGAVELTNPRWQADRVSATFHGRDVFAPVAARLAAGGAPADAGRAVDPSTLIRLPDPVVEVLPDGFTAEVLTVDHFGNVQLAAAAELLLPLPDRVRIRRVGEEGWERTAVHGRTFGDAPTGALVAHADSAGRVALSVNGGRAAELLAVTAGTLLRIDRLAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCR8</accession>
    <name>F4FCR8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732231.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12240"/>
    <dbReference type="EnsemblBacteria" id="AEB43562">
        <property type="protein sequence ID" value="AEB43562"/>
        <property type="gene ID" value="VAB18032_12240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12240"/>
    <dbReference type="eggNOG" id="ENOG50339KE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179041_1_0_11"/>
    <dbReference type="OMA" id="TATIWRA"/>
    <dbReference type="OrthoDB" id="2041175at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="66" mass="7393" checksum="DA16B7ADDDEF876D" modified="2011-06-28" version="1">MRLTDFWTRLEEAFGPGYAASIASDQVLSQLGGRTIEQAFAEGEQTHVVWRAVVAAYPDRVPTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD23</accession>
    <name>F4FD23_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733510.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18765"/>
    <dbReference type="EnsemblBacteria" id="AEB44855">
        <property type="protein sequence ID" value="AEB44855"/>
        <property type="gene ID" value="VAB18032_18765"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18765"/>
    <dbReference type="eggNOG" id="ENOG5030QZQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076574_0_0_11"/>
    <dbReference type="OMA" id="GEGWPVM"/>
    <dbReference type="OrthoDB" id="1253790at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041273">
        <property type="entry name" value="DUF5596"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041644">
        <property type="entry name" value="GNAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18164">
        <property type="entry name" value="GNAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18082">
        <property type="entry name" value="NAT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAT_N" evidence="1">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GNAT_C" evidence="2">
        <location>
            <begin position="175"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="314" mass="35382" checksum="0A4D048320E521F1" modified="2011-06-28" version="1">MDPVDTAARLAVPVEEVERVHRLAGDRPSAPLPAASDAPAILARLAVPPDDAAEIIAGWPDPGSPQWTPELRWLLDRSIALVRADLGGHGWLVPGPELPRDRGPAWRHLYVYAYLALVDVAMAYHRDHGIADAVSWTTLADLGRNLAIDRRMRGEGWPVMQSWLTLHIRGSLYELGRLQHHRAGTTIDLHIPDSGPLSPEAIDASLDQARAFFPRHFPDEHYTAFACGSWLLDPQLAEYLPEDSNIIRFQRRFELEPYEQPDGLDADVEVLRFVFRTLSTPLDALPRRTVLQRAIIDHLAAGHHWQWRRGRFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD93</accession>
    <name>F4FD93_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase, fggy-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734775.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25125"/>
    <dbReference type="EnsemblBacteria" id="AEB46123">
        <property type="protein sequence ID" value="AEB46123"/>
        <property type="gene ID" value="VAB18032_25125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25125"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_2_11"/>
    <dbReference type="OMA" id="HQRTGTW"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="250"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="461" mass="48915" checksum="5E9BBE38185A80D9" modified="2011-06-28" version="1">MNILALDLGTSSVRGLVLGDDIQPVPGALARRRIDLTVDDEGTGTLDARGYLTCLLDCLDELNEQGWLREVGMVAISAQWHSVLPLGVDGQPLGPVLTWLDTRPEPAPTQTGPADPDAYHQRTGTWWHRCYWSVRLPWLRARCGSPVARFVGLVEYALSQLLDDAPMSMSQASGTGLLDISTLDWDPEACALAGVGGDELPQLAPSHWRGRLRPAYARRWPALARASWSPPIGDGAASNVGSGCIDHTRAAVTVGTSSAVRLLQRMPAHAPLAPLPPRLWRYRVDHEHVVTGAAYSSGGNVFAWADRELRLPEGPALEAALWGLSPGDRRPVNVALGGDRPPGSRRAGSGELGGLSFSTTAVQMLAGLMYGVCEQVVDDLAALESTVGAPVEVVLGGGAMAASPWWRAAFVEVLAPRQVRFGRHPEIGATGAALVACDRIADAVELADIGQTDDQSSPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDE1</accession>
    <name>F4FDE1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoI</name>
        <name evidence="8" type="ordered locus">VAB18032_01340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735988.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01340"/>
    <dbReference type="EnsemblBacteria" id="AEB47352">
        <property type="protein sequence ID" value="AEB47352"/>
        <property type="gene ID" value="VAB18032_01340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01340"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_2_11"/>
    <dbReference type="OMA" id="PVVDWVM"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="22452" checksum="97C3C8D9887C5E6B" modified="2011-06-28" version="1">MSERSEPAGVPGSGLVKGLAVTLKTMTKRSTTQQYPDVAPELPPRSRGVIALLEENCTVCMLCSRECPDWCIYIDSHKEEVAVPGAARPRQRNVLDRFDIDFSLCMYCGICIEVCPFDALYWSPEFEYAEYDIKDLLHDKDHLGEWMATVPPPPAHDPNGEPAKEETAAARKAAIPAASAARPTAPPVRPEPASGGTAAPGDGEGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDI3</accession>
    <name>F4FDI3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736029.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01550"/>
    <dbReference type="EnsemblBacteria" id="AEB47394">
        <property type="protein sequence ID" value="AEB47394"/>
        <property type="gene ID" value="VAB18032_01550"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01550"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_11"/>
    <dbReference type="OMA" id="FEKFWFS"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="150" mass="17074" checksum="8EB71ED9CE03000D" modified="2011-06-28" version="1">MTAPADGNSPIEVLLVEDDPGDVLMTREAFEEHKLRNRLNVVSDGAEALAYLRREGQYADAVLPDLILLDLNLPRRDGREVLEEIKNDEQFRRIPVVVLTTSQADEDILRSYQLHANAYVTKPVDFERFISVVRQIDEFFVSVVKLPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDM6</accession>
    <name>F4FDM6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731062.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06325"/>
    <dbReference type="EnsemblBacteria" id="AEB42389">
        <property type="protein sequence ID" value="AEB42389"/>
        <property type="gene ID" value="VAB18032_06325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06325"/>
    <dbReference type="eggNOG" id="ENOG5030KY3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2789259_0_0_11"/>
    <dbReference type="OrthoDB" id="2088475at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="68" mass="7582" checksum="53DE5F4CEB1D575C" modified="2011-06-28" version="1">MADTIAETVDLLYTIDQEKLSVDQQIALSTALATLAQAERLDQINERLRSIQQLLTNATHRSTVDGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDQ0</accession>
    <name>F4FDQ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06445"/>
    <dbReference type="EnsemblBacteria" id="AEB42413">
        <property type="protein sequence ID" value="AEB42413"/>
        <property type="gene ID" value="VAB18032_06445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06445"/>
    <dbReference type="eggNOG" id="ENOG502ZRG0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2132460_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307825" evidence="1">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12080" checksum="86EA1DC73EADDF42" modified="2011-06-28" version="1">MGTARRDLVLTAKAGIVAVLATASVFTVTASAQASFTGNTVEGCYGIGWTRDWNQECVSGGAKKTGNFRTDADCNNSGDKTLTRYRQKGDGQSVDGEDCFTGSLRNLTTWFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDT7</accession>
    <name>F4FDT7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HhH-GPD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12520"/>
    <dbReference type="EnsemblBacteria" id="AEB43618">
        <property type="protein sequence ID" value="AEB43618"/>
        <property type="gene ID" value="VAB18032_12520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12520"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117222_0_0_11"/>
    <dbReference type="OMA" id="HRYPGSM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017658">
        <property type="entry name" value="CHP03252_HhH-GPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03252">
        <property type="entry name" value="TIGR03252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="24"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="193" mass="20842" checksum="2085F21353AF6A01" modified="2011-06-28" version="1">MTLALPIDPQANQLLVSDPLALLVGMVLDQQVSMEKAFSSPYVLTQRLGHDLDAREIAGYDPEALVALFAQPPALHRFPKAMAARVQEVCRALVAHYDGDAARLWADAADGRELLARIAALPGFGRQKAQIFLALLGKRFGVQPPGWQEAAGDYGDPDAHRSVADVTDAESLRLVREYKQQMKAAAKAKATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE33</accession>
    <name>F4FE33_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Non-ribosomal peptide synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_19000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733557.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19000"/>
    <dbReference type="EnsemblBacteria" id="AEB44902">
        <property type="protein sequence ID" value="AEB44902"/>
        <property type="gene ID" value="VAB18032_19000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19000"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_49_0_11"/>
    <dbReference type="OMA" id="WCEAMAG"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1388"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1418"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1450"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1483"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1545"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1596"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1628"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1659"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1682"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1717"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1747"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1772"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="12">
        <location>
            <begin position="1385"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="970"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1361"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB44902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1832" mass="196429" checksum="F143E53132BDC450" modified="2011-06-28" version="1">MTDVDAPAWSRTDSPELRRSTDRPRLSFAQERIWFTEQLTPGTAAYVIYATVRLHGALEIDLLRTALDATAARHDSLRMRFTENADGEPVVQVLPEVRVPVTVTTAESEQAARELVTAAVDTPFDLAAAPLLRALVVRIDDEQQLLHLAMHHIVSDGWSLDILLGEVAATYGALRDGGTAPAAPSTGYLDYAAWQRARLDGPASGDGFAYWHTALADVPPLDLPTDRPRPAVLSYAGGTHRFAFDADLTDGLRRLGRTHRSTLYMTLLAGLQAVLFRYSGQRDFAIGSPVAGRVVPELERLVGLFVNTLALRADLSPIATGPDGPAEPSFAALLKRTRGTVVRALAHQEIPFERLVADLNVARDVSRTPVFQVLFTLQNYDQGGTGWPAGLRAEGVGTDASTARFDLSLYVGESADGLRGMVVYNTDLFDAATVRRLAASFETLLRGAVAAPDRPVIDLDLLDPTERDRTLALGRPDTDGTTGVTGGATTLADLIDRHVAATPDAPAVVGEQSQTLTYRRLDRRANQLATWLRGKGVGPDTLVGVLLEQSVELAVTLLGVLRAGGAYLPLDPEQPAARLGLMLADARPSLVLTSADLRDLLPAELPTACLDEVAAEVAVGPDTAPEATATGDNLAYVIYTSGSTGTPKGVAVAHRQVLRYLDGVADRFAIVPAARYGLLQSMSFDFSVTVFYLALATGGAVHLLPRRCTGAELAERLRARHIDYLKITPSHLTALTADAEPGDLLPARALILGGETSDLERIAPLATGPARIFNHYGPTEATVGVTTYEVPATEAGTGAVPIGRPLPHARVYLLDERMRPVPVGVPGELYLGGDRLARGYLNRPELTAQRFLPDPYGPPGARLYRTGDLARWRNDGQLMFLGRRDHQVKIRGYRVELGEIEAALRDCPEIRQAAVLLRDDRLVAYLEPATETDPPQPAQLRRRLAERLPEHMLPSRWVLLDRLPLQDHGKVDRRALPAPTDEPTTDAERVAPDGPVETLIAGIWQAVLGIAQVGAGDDFFDLGGHSLLATQVVARLRRELPEVLGTAAPTVSVMDLFRHRTVRELAQLVGGDATGDSGLLYELTPPVPTGQRIATLVCVPYGGGSAVVYQPLADALPPGHRLLSVAVPGHDIGVADDPAPIDQVAADVVAEILDRVSGPLILYGHCGPGGALVVEVARRLEAAGRELTAVYLGAVFPFGRPAGGLLGPLLRLRLAERLRSDRIYRTWLQAQGTNIGQLAPDEVRFLIRAMRHDAEVSEEYFTELMRRRVTPLRAPIISVVGERDRGTEFHEERYREWHFLSDRTALAVIDEGGHYFLKYRAVELAEIVTDVHRRIDTPAPAAVETSTGVDPEPAWQLAAVSDRGAEPPPTGRSRTDTAPAPSMRRFGLVAAGQITSGLGTALTTFAVPLWIYTQTGSLARFALFAVLALLPGLLIAPLAGALVDRFSRRAVLLTACVAAGGGNAALAVLVLLDRVEVWHFYPFTAWLSVALAFQRLAFVSAVPQLVPKRFLGHANGLAQTAVGLTQFVVPLAAVALLQAVGLRGILLVDVACYLFAITVLAVVKFPRTLALQRRESIGAEILAGLRYALRRREFRAMLTFFAALNLFLFPVLFLLSPLVLGFASLDEVAQVALTGGIGAATGGLVMLVWGGPRHRRMRAVLLGTLGIAAAAMLTGLRPNLALIAAGAFGMYASLAIVNGVYATIIQTKVPPRVHGRVFALNQMVAQSTLPLGWGLIAPAAARITEPMLLADGVLAGTVGVVLGVGPGRGHGLLYVLFGLCIAITALISLITPVLARFDDQVPDAPPDDLVGIEDRRARAAAVTPVPADRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEZ4</accession>
    <name>F4FEZ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid-binding act domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12960"/>
    <dbReference type="EnsemblBacteria" id="AEB43706">
        <property type="protein sequence ID" value="AEB43706"/>
        <property type="gene ID" value="VAB18032_12960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12960"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086331_0_0_11"/>
    <dbReference type="OMA" id="PMFRAAE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="250" mass="26080" checksum="100A327188ECE0A2" modified="2011-06-28" version="1">MISLPALVLARRAEGFEMLLRVRVTLPDRPGTLGQVARTLGVSGADIVQVVVLERLGGRAVDDFTVVWPGAARVERLLAGLAAIPGVRVDGVWRAIGAPTTTGQDAELLAQVAANPADGLATLVDAVPGLLAADWAVAAVVPVDWASRTGGGGATVAHASWRTPEPPRLPEVTPLRARSMTMRDGGHFAVAPFGRAGLVMVVCREHSESLTPATFHSTEVDRLAQLVRASAVILGDRLDLVDVPPISATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF76</accession>
    <name>F4FF76_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_19395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19395"/>
    <dbReference type="EnsemblBacteria" id="AEB44981">
        <property type="protein sequence ID" value="AEB44981"/>
        <property type="gene ID" value="VAB18032_19395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19395"/>
    <dbReference type="eggNOG" id="COG4208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_0_11"/>
    <dbReference type="OMA" id="NEYNFVA"/>
    <dbReference type="OrthoDB" id="1110665at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011866">
        <property type="entry name" value="CysW_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF1">
        <property type="entry name" value="PTHR30406:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="65"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB44981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="29827" checksum="79078F40006E249D" modified="2011-06-28" version="1">MAEHSITTRNQVGRRPGRYVLRAVVTAYLFLLVAWPLYLVGRNALADGFTSLGDILTDPDVTHALRLTVVIAVTAVVINTVFGVGISILLVRYDFPGKRTLNALLDMPLSVSPIVVGLALVLVYGGREGWFGPTLESAGLQIIFATPGMVLATVFVALPLVIREVVPVLQEIGDEQEQAARSLGANAVQTFRRITLPAIKWGVIYGVVLSLARSLGEFGAVKVVSGNVLGETRTATLVVEEKYLNFDKGGSYATAFLLALVAVACIIVVSVLRPKEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF95</accession>
    <name>F4FF95_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733655.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19490"/>
    <dbReference type="EnsemblBacteria" id="AEB45000">
        <property type="protein sequence ID" value="AEB45000"/>
        <property type="gene ID" value="VAB18032_19490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19490"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1730649_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="151" mass="16573" checksum="12124F087352E892" modified="2011-06-28" version="1">MRLPGQVRYAGRLPSGTTAAAFVALDRVRRQPLDAAAEQRAATAAFDLAYHALPASRRRLFRCLGLHPGPDFDVCAAAALGNLTLVHARRTLADLVERRLVVECGVRYRIPDLIVEHARRLALDEPAVLRTAALVRLANMDRIPHPRRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFE6</accession>
    <name>F4FFE6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734900.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25750"/>
    <dbReference type="EnsemblBacteria" id="AEB46248">
        <property type="protein sequence ID" value="AEB46248"/>
        <property type="gene ID" value="VAB18032_25750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25750"/>
    <dbReference type="eggNOG" id="ENOG50332QW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1894691_0_0_11"/>
    <dbReference type="OMA" id="VAVRWEF"/>
    <dbReference type="OrthoDB" id="1667181at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="129" mass="13886" checksum="D3381336C6B97D33" modified="2011-06-28" version="1">MTASTDLDALTDFFDRYGVALTSGDLPAIAGCYTLPGLVVADTYSFSFTSTAAVALSFVGAAPDYSERELVAAHADIEQIQPISALLTLVAVRWEFLDSQGRQVPGERYRYLLRTTDDGPVICTVVRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFT9</accession>
    <name>F4FFT9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731192.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06975"/>
    <dbReference type="EnsemblBacteria" id="AEB42519">
        <property type="protein sequence ID" value="AEB42519"/>
        <property type="gene ID" value="VAB18032_06975"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06975"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_1_0_11"/>
    <dbReference type="OMA" id="CEDPWLV"/>
    <dbReference type="OrthoDB" id="919913at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="366" mass="40511" checksum="0EBE4D4815C19E80" modified="2011-06-28" version="1">MTLRLHWFLPLHGDGREVAKSADGVAEARNIRREPELNYLGQVAQAVDGLGFAGALVPTGLFCEDPWLVSAALSQQTRNMHFMIACRPSSLPPMVCAQSAATFQRLSGSRLMLNIVTGGDADEQRRYGDWLDHDERYARTEEFLDVFHQAWRGEPFDFHGRHYQIKAGLLSRPHDVRPTILLGGSSAAAQRVAAAHADVYLAWGERPDGLTSLTSRVSELAAERGRSVEFGTRFHVISRDTAQEAWAVTRRLLDGMDASRIADAQRRFRRTESEGQRRMAALHGGRTDDLEVYPNVWAGYGLVRPGAGAALVGSHEQVAERIAEYHALGMNHLILSGQPHLEEAYNFAEGVLPLLRRQGLLGQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG23</accession>
    <name>F4FG23_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732434.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13265"/>
    <dbReference type="EnsemblBacteria" id="AEB43767">
        <property type="protein sequence ID" value="AEB43767"/>
        <property type="gene ID" value="VAB18032_13265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13265"/>
    <dbReference type="eggNOG" id="ENOG5032ZIV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122355_1_0_11"/>
    <dbReference type="OMA" id="IWAVEFH"/>
    <dbReference type="OrthoDB" id="1986389at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013434">
        <property type="entry name" value="CHP02611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02611">
        <property type="entry name" value="TIGR02611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="138" mass="15376" checksum="34A94280A8DF94EF" modified="2011-06-28" version="1">MPERRDRPRWRRRVSTTLALIRSNPTGRLALRVIIGVLGALVVAVGILLIPLPGPGWLIVIAGLGIWAVEFHWAKRLLTFTRRHVHGWANWVKRQSLAVRFVLGAVGIVFVGAVALISIKLSLDIDVIAQVLHYFATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGN8</accession>
    <name>F4FGN8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735024.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26375"/>
    <dbReference type="EnsemblBacteria" id="AEB46373">
        <property type="protein sequence ID" value="AEB46373"/>
        <property type="gene ID" value="VAB18032_26375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26375"/>
    <dbReference type="eggNOG" id="ENOG5031TCX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="WAAFIAR"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="6891" checksum="454FBD6BDDADA438" modified="2011-06-28" version="1">MDNLTGARWRTSSRSSTNGGVCVEVADNLPGVVGVRDSKDPTGPALTFTPAAWRAFLTRFPERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGZ0</accession>
    <name>F4FGZ0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42604">
        <property type="protein sequence ID" value="AEB42604"/>
        <property type="gene ID" value="VAB18032_07410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07410"/>
    <dbReference type="eggNOG" id="ENOG5031SES">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2845011_0_0_11"/>
    <dbReference type="OMA" id="VWRACLY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="63" mass="7079" checksum="0303C6E9115F75FB" modified="2011-06-28" version="1">MLLRGGPGDGQVVTGGGEAVVWRACLYEITTEFTHRHGHDLRVYRHRTDCCEPHARGAEDRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH13</accession>
    <name>F4FH13_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07535"/>
    <dbReference type="EnsemblBacteria" id="AEB42627">
        <property type="protein sequence ID" value="AEB42627"/>
        <property type="gene ID" value="VAB18032_07535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07535"/>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005511_0_0_11"/>
    <dbReference type="OMA" id="HTRAEQI"/>
    <dbReference type="OrthoDB" id="956321at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1166" mass="123967" checksum="57831CA50AB568F3" modified="2011-06-28" version="1">MRPVRSAYLEQVKRIAPPELLGRDTELAELAAFCLDPDRSPYVCWRAEPWAGKSALMSTFVLRPPPQLTGRVRIVSFFVTARLAAQDTRVAFTTVLIRQLCELTGQDWPAMVDEASREELMLDLLRQAAAACQVDGGRLVLVVDGLDEDRGVTSGPDAHSIAALLPAAPPHGMRVIVAGRPNPPIPDDVPDWHPLRDPGIIRLLAPSEHAHDLQRLGQSELKRLLKGNQIEQDLLGLLTAARGGLSGTDLSELADADLVHIEDVLHTVAGRTFARRVNQWAGAPEAEVYLLGHEELQRAATRYLGSTRLADYRDRLHAWAERYRQSGWPPHTPEYLLRGYASLLQATGEVERLVTLATDARRQDRMLVLSGGDAAAFDEIRAAQKLVMAQPTSDLLAMARLSFGRDNLASRNANLPAGLCAVWAALGDLARAESLARTIPNLRQQTRALAVLAEVAAEAGNADRAGRLASDAETIARTITNPLEQAQALAVLAEVAAEAGNADRAGRLASDAETIARTITNPLEQAFALAKLVEAVVLIGDADRAEAIVREVAEQLGQASVLKELVWVTALAGSADRAEAIVRGIKDPSDRARALAALARGVAESGDATRAEAIARTMPDPTYQASVLVKLVRMATETGDADRAGRLASDAETIARTITNPTYQASVLVKLVRMATETGDADRAGRLASDAETIARTITSPHEQTQVLAALAEVTAEAGDDARAGRLAADAETIARTIARPHEQTRALAALAEATAEAGDAARAEVIARTIPDPTHQASVLVKLVRMATETGDADRAGRLAADAETNTRSITDPFAQAITLVELVQVVAEAGDPGRAETIARSITRPYAQAWALAALARFVAGAGDADRARRLAADAETIAHHITHPSDRADTLAAVARFVAGAGDADRARRLAADAETIARSMSDPLPQARTLVKLVKVVAEAGDPSRAETIARSILRPYAQAQAHAALALGVAEAGDAARAEAIARSISEPFVQASVLVRLVQVAARAGNTDRARRLAADAEARSRRITDPSGQARALTALARVVAETGAADRAGRLATDAETISRSITISEQESVLMELVEVVAGAGDAARAEAIARSIKVPSTRARALVAVAGVAGTPRARRLLGEAFAIGHWLIPLPVLAKHWPHLVIQVADEHMRMMKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH54</accession>
    <name>F4FH54_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732499.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43832">
        <property type="protein sequence ID" value="AEB43832"/>
        <property type="gene ID" value="VAB18032_13600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13600"/>
    <dbReference type="HOGENOM" id="CLU_2940550_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="60" mass="6424" checksum="083445955E304D07" modified="2011-06-28" version="1">MAGLTRSRRRDLLRGGALVTFGAGLGVVDFAEAADVADRRLPIRAAPQTSRCRARIRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH67</accession>
    <name>F4FH67_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding 9, siderophore-interacting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732512.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13665"/>
    <dbReference type="EnsemblBacteria" id="AEB43845">
        <property type="protein sequence ID" value="AEB43845"/>
        <property type="gene ID" value="VAB18032_13665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13665"/>
    <dbReference type="eggNOG" id="COG2375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040923_2_0_11"/>
    <dbReference type="OMA" id="PYAWIAG"/>
    <dbReference type="OrthoDB" id="1630289at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="34795" checksum="DF2DCBD5E4731B34" modified="2011-06-28" version="1">MTNTLPVAPWRLFSVEIRAVRRLSPSFVRVTFTGPDLDRFADNGYDQRIKLALPLPGQRAVYLPQGPDWYAQWRALPEHRRNPIRTYTARAVRPHLHELDVDLVLHGDGGPASRWAQQVRPGDEIAIAGPDAGYEGDHGGREFRPPSTGCLLLAGDETAVPAISGICERLPLDACGRVLLEVPDPADVLPLVAPPGVEVTWLPRNGGQYGDRLIGAVADAARDLLAASGGGQHRQSTPQPHVPVAGDGMADGAPVDDVDVDTTILWEVPDVPPSAPLYAWLAGEAGVIRTLRRHLVSDCALDRRAVAFMGYWRQGRPDPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH81</accession>
    <name>F4FH81_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732526.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13735"/>
    <dbReference type="EnsemblBacteria" id="AEB43859">
        <property type="protein sequence ID" value="AEB43859"/>
        <property type="gene ID" value="VAB18032_13735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13735"/>
    <dbReference type="eggNOG" id="COG3145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048788_4_1_11"/>
    <dbReference type="OMA" id="QRTWEHC"/>
    <dbReference type="OrthoDB" id="1309191at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="111"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="23183" checksum="3F724C38929121D5" modified="2011-06-28" version="1">MSQASYQPSMLDVTDAEPTLGSLPGRLRRHPLSRGAWVDHLPGWVHGSDQVLDVLLREVPWRAERRTMYDAEVDVPRLLCWYGAGRPLPHPVLSAARTTLTRHYADELGEAFVTAGMCLYRDGRDSVAWHGDTQGRSAHTDTLVAIVSFGSPRHLLLRPRGGGASLRFPLGHGDLVVMGGSCQRTWEHAVPKTTRPVGPRVSVQFRPAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHE5</accession>
    <name>F4FHE5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_20075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733772.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20075"/>
    <dbReference type="EnsemblBacteria" id="AEB45117">
        <property type="protein sequence ID" value="AEB45117"/>
        <property type="gene ID" value="VAB18032_20075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20075"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_0_11"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="416" mass="45690" checksum="D2C9CFCCA465D88A" modified="2011-06-28" version="1">MSGLPSAGHALLLDPSTRDDPTLYRRLHAEAPVLRTAGLWLVSGYQQVSRLAGDPRLVIDPRAGDPPLPLTQSERLESIFGGMLSFRDGAAHRRLRQLVSGAFSARRTNALDRTVRDLVAGLIAQAGDAEFDVVPAIAERLPVLTTCRLLDLPTEHWSRVDAWARTLTGQLFRFGQSADQLAEVHRQVDEMTRFIDDLAAERRDRSGDLVAELLDAAQGADARLSHDEFVSFVVLLFINGLETATAAISICVAQLLHRPELAARLRREPDHALEVVDECLRLQSPVWLAARRSLAPIEVDGQVIETNDPVFLLWAVANRDPAIFAYPDEFRPGRAGRHLAFGRGPHHCLGAAMARVQAAEVLRQLAAYEHLRAGAGPARRRHTAALNTYDSLPVTVTPAGEPLSRRAEARLHATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHE6</accession>
    <name>F4FHE6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733773.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20080"/>
    <dbReference type="EnsemblBacteria" id="AEB45118">
        <property type="protein sequence ID" value="AEB45118"/>
        <property type="gene ID" value="VAB18032_20080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20080"/>
    <dbReference type="HOGENOM" id="CLU_2848629_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="6833" checksum="DA64C6E0107E761C" modified="2011-06-28" version="1">MRDFGADSISVIRARAAALAASWLDGEAGAPQDLLRVENLATGPTEPVPCFCLGTFCWVGTPLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHQ4</accession>
    <name>F4FHQ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TraR/DksA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_26751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26751"/>
    <dbReference type="EnsemblBacteria" id="AEB46423">
        <property type="protein sequence ID" value="AEB46423"/>
        <property type="gene ID" value="VAB18032_26751"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26751"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_3_0_11"/>
    <dbReference type="OMA" id="TIAFERA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="50"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13945" checksum="DA7869F3128CFB3C" modified="2011-06-28" version="1">MKSTRSAAETDKIRAALAARHDELRAEYDQTLSEITELQRERLTDSAGDDQADTGTKTFEREQEISLANSILERITQVERALERLDEGGYGWCERCGNPIPVERLAAFPSATLCVTCKQLAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHS9</accession>
    <name>F4FHS9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_26876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735099.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26876"/>
    <dbReference type="EnsemblBacteria" id="AEB46448">
        <property type="protein sequence ID" value="AEB46448"/>
        <property type="gene ID" value="VAB18032_26876"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26876"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="OMA" id="FMARVSI"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="52"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="245"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="350" mass="38400" checksum="FD340F3BABCF88D6" modified="2011-06-28" version="1">MTQQTWDEVGGLLPFDEFRAASDAIVANIEQVIEGKTATVRLALAVLLAEGHLLIEDVPGVGKTKLAKALARSIDCSVRRIQFTPDLLPSDVTGVSVYNQETHDFEFRPGAVFANLVVGDEINRASPKTQSALLECMEERQVTVDGVTYQLQTPFMVIATQNPIEMEGTYPLPEAQRDRFTARIAMGYPDPTAELAMLDAHGAVDPLAALRPVSDAETVRRLIGHVRQVHVADAVKQYAIDLVTATRESPDLRLGASPRCTLQLLRTARAVAALDGRDYVLPDDLQVLAVPVLAHRLIPTADAQLARRTTDAIIADLVHRLPLPHDRKRSPYDNRPPTGNGRPPFEPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHW2</accession>
    <name>F4FHW2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="7" type="ordered locus">VAB18032_02855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02855"/>
    <dbReference type="EnsemblBacteria" id="AEB47655">
        <property type="protein sequence ID" value="AEB47655"/>
        <property type="gene ID" value="VAB18032_02855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02855"/>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_3_11"/>
    <dbReference type="OMA" id="YHETIYD"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="155" mass="17143" checksum="49A76EE0B5A49CDA" modified="2011-06-28" version="1">MARAYAELFAGLRVDPATVLTTTFEANHEELVLVRDIDVMSLCEHHLLPFRGSAHIGYIPGPDGRITGLSKLARLVEVYARRPQVQERLTSQIADLLMDRLAPRGVVVVLECEHMCMAMRGIQKSGAKTITSAVRGTLQRDAKSRAEAMALIHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI12</accession>
    <name>F4FI12_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_03105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736337.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03105"/>
    <dbReference type="EnsemblBacteria" id="AEB47705">
        <property type="protein sequence ID" value="AEB47705"/>
        <property type="gene ID" value="VAB18032_03105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03105"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_13_2_11"/>
    <dbReference type="OMA" id="PIMIAAN"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="218"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="417" mass="44147" checksum="366B02185C4A9458" modified="2011-06-28" version="1">MTLLGHHDFRLLWTAQTLGQFGTHFSRVGLPLVAILALDATAFEAGLLATFQTVAFLLVGLPAGAWVDRRRKRPIMIAANLGRGLLLAWVPVGAYLGVLTLTQLYIVALGVSVGTLLFETAYVSYLPLMLERGQLVEGNAKLESTRSVAQVGGPTLGGYLVQWFGPPLAVLTVAGGYLASALAVSRIRMREALPVRGASSHLVGEIRQGLSYVFRHRVLRALAVSGALFNLGVYVTGTVVVVLLAQQLRISPGTVGLWFAIGGLGGLVGAFVVQRISVRLGPGPTVWVGMAVAGVAGLVVPLADADWRLWLAGAGNALVSTGLVINNVNSMAIRQQLCPQELQGRMNATIRFLVFGAMPIGSFLGGFLGEQIGLRETLWVGAVLSLVAVLPVYFSPLRTMRGQPDADDQKAAPEKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F179</accession>
    <name>F4F179_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_14015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14015"/>
    <dbReference type="EnsemblBacteria" id="AEB43915">
        <property type="protein sequence ID" value="AEB43915"/>
        <property type="gene ID" value="VAB18032_14015"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14015"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081811_1_1_11"/>
    <dbReference type="OMA" id="GAHCIIN"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
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        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
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        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03570">
        <property type="entry name" value="NeuD_NnaD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PglD_N" evidence="3">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="23305" checksum="6262457635C9E10C" modified="2011-06-28" version="1">MQVRRHQETTLPQASLDLVIVGCGGHGREIAQLVAAANEAAGRVVWQPVGFVDDAPSDVNRKRAEATGLPYLGTLAVLGQLPPQTHVTLALGDPRVRRTVAARVDSFGLPVASLVHPDATVGTDLVCAEGLVVFAGARITTNVTAGRHLHVNQNATLAHDCVVGDHVSLHPLAAVSGDCRLDTAALIGAGAVVLPRLRVGAGAIVGAGACVVRDVPPDTVVKGVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F180</accession>
    <name>F4F180_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent hydrolase of the beta-lactamase fold-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14020"/>
    <dbReference type="EnsemblBacteria" id="AEB43916">
        <property type="protein sequence ID" value="AEB43916"/>
        <property type="gene ID" value="VAB18032_14020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14020"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_0_0_11"/>
    <dbReference type="OMA" id="QHWTRRT"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003308998" evidence="1">
        <location>
            <begin position="32"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="130"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="379" mass="41650" checksum="F3D32F63997FEBDD" modified="2011-06-28" version="1">MRASKKVTGRRISGSMAGLAALAGLAGLAWAARDVPAALGGRLAGARADRAARSPQFRDGVFHNRPGTPITAPAPDRNLLRELLFGKQKRRPSAPVPLVRPVAATPVDPARELNVIWYGHATTLVEIEGRRVLLDPVWSERCSPSATLGPRRLHEPPVRLDELPHLDAILISHDHYDHLDMATVRELTARQSAPFLVPLGVGAHLDRWGVPADRIIELDWTQTHRVAELEITCAAAQHFSGRGLRRNGTLWSSWVVAGRQRRVYYTGDSGYFAGYAEIGAAYGPFDVTLIQIGAYDHAWASIHMFPEEAVAAHVDLRGGLLVPVHWATFNLALHDWSEPVDRLWAEAKARDVRLAVPRPGERVTVDDPPSVDGWWQAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1I5</accession>
    <name>F4F1I5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733868.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20570"/>
    <dbReference type="EnsemblBacteria" id="AEB45214">
        <property type="protein sequence ID" value="AEB45214"/>
        <property type="gene ID" value="VAB18032_20570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20570"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_1_11"/>
    <dbReference type="OMA" id="QWGAHEV"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="46"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="27671" checksum="2A1E6F1429A9136C" modified="2011-06-28" version="1">MDLAHSPWQAPLIWRAAQALARGVVALLARLEVTGDLPASLRDRPLILAANHISPFDPIVLTAACRQRRIAPRIMATGGLFRVPVIGAAMRAAGHIRVDRGTSAVHRALDDAAAAVTAGAVILVYPEGRISLDPGLWPERGKTGTARLALACGAPVIPVAQWGSHEVLPYQAPKGLLGGVTRALLRRPTIRVHFGEPVPLADLTASRPGVARLATDRIIDALTDTLAPLRPDEPDRPRHVDPGRPVDTSRSHRRRTAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1P7</accession>
    <name>F4F1P7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_26996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26996"/>
    <dbReference type="EnsemblBacteria" id="AEB46472">
        <property type="protein sequence ID" value="AEB46472"/>
        <property type="gene ID" value="VAB18032_26996"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26996"/>
    <dbReference type="eggNOG" id="COG3200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026885_0_1_11"/>
    <dbReference type="OMA" id="KVMMQMA"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="452" mass="49852" checksum="67CE84459298CCCF" modified="2011-06-28" version="1">MLQTSRPTVDSAEDEALGLDRWRELPRAQIPPWEDPAQVAEVCKVLDRVPSVVAPYEVDQLRQRLALVCEGKAFLLQGGDCAETFADNTESHLLANARTLLQMAIVLTYGASLPVVKVARVAGQYTKPRSLPTDARGLPAYRGDMINSLEATPEARVADPQRMIRAYANSAAAMNMLRAYLAGGLADLHAVHDWNKGFVRNSPAGERYEAIAREIDRALAFIRACGMTDDEALRTVTLYCSHEALALEYDRALTRVSDRRAYGLSGHFLWIGERTRQIDGAHIDFISRIANPIGVKLGPTTTPDEAIELCEKLNPENIPGRLTLISRMGNHKVRDALPPIVAKVTAAGAKVVWQCDPMHGNTHESSNGYKTRHFDRIVDEVLGYFEVHRSLETHPGGLHVELTGEDVTECLGGAQNIADLDLPDRYETACDPRLNTQQSLELAFLVAEMLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1S0</accession>
    <name>F4F1S0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27111"/>
    <dbReference type="EnsemblBacteria" id="AEB46495">
        <property type="protein sequence ID" value="AEB46495"/>
        <property type="gene ID" value="VAB18032_27111"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27111"/>
    <dbReference type="eggNOG" id="ENOG5033H36">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234574_0_0_11"/>
    <dbReference type="OMA" id="AECCICP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="224" mass="22269" checksum="BB2B9931735F779D" modified="2011-06-28" version="1">MGATDPGSARQEAERLVATLLASARLAAGNPGTGPLGSLSGIMTSVLGHNDSSEEPEGATGPGFATGAPECCVCPVCRGIAALRDPSPEFAERLATGAGDLAAGLASFLRAFAPPETPDDPSSGPGGDPDSDHVWREATRTGHDSQPAPDRHVWTAATRAEEGAVPAVPPVDAAGPVADAVGPTPETGRPVVPASRTPDGERRTASEAAAPTSAEQQGAAGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Y9</accession>
    <name>F4F1Y9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736368.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03260"/>
    <dbReference type="EnsemblBacteria" id="AEB47736">
        <property type="protein sequence ID" value="AEB47736"/>
        <property type="gene ID" value="VAB18032_03260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03260"/>
    <dbReference type="HOGENOM" id="CLU_1562224_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="171" mass="17974" checksum="3D637EB7744EE8DE" modified="2011-06-28" version="1">MPDSAAADGLLAVHDGLRTALAGRPEIHVAWGPELAEDTSPAAAALRAVEASWEWSALGFASRSFWDLHVGILPVESGFSVGLHWTRALDHEVRPWAPIAVPGGTLRFAAVAGEYQLLTADSTGVATHSIRSAVDVALAVATRVLSKITDDAHPAEVFAPTDCTTREKTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F212</accession>
    <name>F4F212_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M23B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_03375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736391.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03375"/>
    <dbReference type="EnsemblBacteria" id="AEB47759">
        <property type="protein sequence ID" value="AEB47759"/>
        <property type="gene ID" value="VAB18032_03375"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03375"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089640_0_0_11"/>
    <dbReference type="OMA" id="WWIRRGV"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309014" evidence="2">
        <location>
            <begin position="35"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="103"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="254" mass="26590" checksum="A3636DFF2DEC67D9" modified="2011-06-28" version="1">MVALTGRRHLPYAALLLVPVLAAGCATGPGPTWSAPTSSPTSATTGTSPTAPASTTPTAAGSPGPESADQPAPTATPGADRLPHVFPVRARNVDYHPTHSGYPGTDIFADCGEPFVAVTDGTVGEVSRRDRYDKRGPQGPYNGGLSVSVLGDDGVRYYGSHLTEIAVGIEPGVRVRAGQQLGTVGRTGNANNVCHLHFGISPPCLGEDGWWIRRGVVWPAPYLDSWRRGGNRAPAAEVARWHRRHGCPAKPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F223</accession>
    <name>F4F223_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03430"/>
    <dbReference type="EnsemblBacteria" id="AEB47770">
        <property type="protein sequence ID" value="AEB47770"/>
        <property type="gene ID" value="VAB18032_03430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03430"/>
    <dbReference type="eggNOG" id="ENOG502Z7TU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027642_0_0_11"/>
    <dbReference type="OMA" id="KWVALAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="586" mass="60850" checksum="5ABA996E93620A62" modified="2011-06-28" version="1">MRERLRQGGPAAERGRAVGRLVPHLVAAAVTAVVLAPLARPGYVLRYDMVFVPRQALSWEVIAPATALPRAVPQDAVVALANQLVPGWLLQRLVLVAILYFAALGAARLVPTRRTAVRVVAALGYAWTPYLAERLLIGQWGLLVAYAAMPWLVRAAIGVRAGERGALRRLLLAAAVSAITPTGGLLALVVVAVLLVGPGTARSASVGVGVTLLLNAPWLVAGFTSAGDGRSDPAGVAVFAARAENWAGPLVALAGTGGIWNAQATPASRSGLLVPVATGLLLVVAAAGVPLLRRRWAAGVTNRLGLLAVGSWLAAVFGVLPGAVTVLGWLVANVPGAGLLRDGQKLLVPYALLLAVAVALGAERLAGWLTARFDAATGRVLLVGAALLPVAVLPDLAFGGVGRLRPVAWPADWAVVARLVQERPGEVISLPFQEYQSYSWNDDQVVIDPAPRYLGVPVLIDDTLRVDGTAVAGEDPQAARVRDLLDAGEPVATAGPRWVLVQRAAGPPVDPATLDGLHRVYAGDDLTLYENPQWRPAPAPARPGPVGLAHLLAATVVLAIGFLDAARRSYRVVASRHASPAEGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F229</accession>
    <name>F4F229_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736408.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47776">
        <property type="protein sequence ID" value="AEB47776"/>
        <property type="gene ID" value="VAB18032_03460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03460"/>
    <dbReference type="eggNOG" id="ENOG5032SAM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124874_0_0_11"/>
    <dbReference type="OMA" id="DLHPCSC"/>
    <dbReference type="OrthoDB" id="1535683at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="18988" checksum="4F360197A29EEF4A" modified="2011-06-28" version="1">MNPPLSRTSAEAHLYMDLHPCSCGSTRFPRHSAVVALADGDLASRYTGTCEGCGAEREFVFRLPATPGRTSGGFRYGGNEPSQLLDPGEWLLVADAYAGSVPAESAGEAGQRARAALTRAVAALDEVGKFAPEGGGEIPASAFVSDRGRQLHQREPGRFRRERLAAVRGSYAELLARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2F9</accession>
    <name>F4F2F9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14595"/>
    <dbReference type="EnsemblBacteria" id="AEB44031">
        <property type="protein sequence ID" value="AEB44031"/>
        <property type="gene ID" value="VAB18032_14595"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14595"/>
    <dbReference type="eggNOG" id="COG2306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083275_1_0_11"/>
    <dbReference type="OMA" id="YANLEAP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="2">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="234" mass="26179" checksum="C7A67D5AD9873B0D" modified="2011-06-28" version="1">MVIRREILHGEAWFACPTICVEDSPDLLALYLPPGAEFGFPVEGRFPCGRHPWQLAGHRAWSGHGKLMLQRPGEAHAVDVFWSGPQRAFAGWYFNLQDPFRRTPIGVDTLDHELDLWWAADADRYVFKDVELFAQRLVEGRYPGMAEAIRAEGDRIAALLDAGQRWWDESWATWHPDPTWPVPRLPAGWDTLPYSADTGSPDELVPAASGVPVADDHDHAGDGGDHTAGQDDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2H8</accession>
    <name>F4F2H8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_14690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732717.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14690"/>
    <dbReference type="EnsemblBacteria" id="AEB44050">
        <property type="protein sequence ID" value="AEB44050"/>
        <property type="gene ID" value="VAB18032_14690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14690"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_6_0_11"/>
    <dbReference type="OMA" id="PWYGIGR"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="26178" checksum="B4682F5A0C862529" modified="2011-06-28" version="1">MPSPVTDLALGPDWLEPEWLISTFGLIGILVIVFAESGLLIGFFLPGDSLLFTTGLLVADGQYLKYPLWLVCLLITVAAIAGDQVGYLFGRKVGPALFRRPNSRLFKQENLLKAHDFFEKYGARSIVLARFVPIVRTFTPIVAGVSRMNYRTFVIYNVVGGILWGTGVTVLGYFLGQIPFVKANIEFILIGIVGISVLPIAVELLRAWLAARRGTTPQEQAAAEEAIRETRQHYGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2P2</accession>
    <name>F4F2P2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnhA</name>
        <name evidence="8" type="ordered locus">VAB18032_21035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733961.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21035"/>
    <dbReference type="EnsemblBacteria" id="AEB45307">
        <property type="protein sequence ID" value="AEB45307"/>
        <property type="gene ID" value="VAB18032_21035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21035"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_6_0_11"/>
    <dbReference type="OMA" id="MQEIEIF"/>
    <dbReference type="OrthoDB" id="1953872at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="155" mass="16930" checksum="BAF5DD0C44B581E7" modified="2011-06-28" version="1">MVDEAAGRVVQIWTDGACSGNPGPGGWGAVLRYGAHEREICGGEATPTTNNRMELTAAIKALESLTRPVTVELHTDSTYVRNGITSWLASWKRNGWLTAARQPVKNADLWQQLEAACARHRVTWLWVKGHNGHPENERADALANQGMTEARSATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2S5</accession>
    <name>F4F2S5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_21200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733994.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21200"/>
    <dbReference type="EnsemblBacteria" id="AEB45340">
        <property type="protein sequence ID" value="AEB45340"/>
        <property type="gene ID" value="VAB18032_21200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21200"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="YASTDWG"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="271" mass="29351" checksum="893E5D50AF83A3A5" modified="2011-06-28" version="1">MKTSLGFRIFRTVALVVVVLSLVAPLVWMVAASFKTNVDIYDTSKALIFSPTLDNYGTVLQQANYIQFIGNSLWVAFAATVLSLLLGVPAAYSMSRFNMRKSALVVLMARVIPGVSLLVPWYYVFSNLRMVGGFSVLILSHMFVSLPLIVYIMMGFFDGLPDELEEAAQVDGLTPIGAFRRVTLPLSVPGIATAGILSFIFSWNNFMFALVLSGADTKTLPVAIFDFVGYASIDWGGLMAATTVVTLPIMIIALFVQKYIVSGLTAGATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2T7</accession>
    <name>F4F2T7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminomethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gcvT</name>
        <name evidence="9" type="ordered locus">VAB18032_27376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735198.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27376"/>
    <dbReference type="EnsemblBacteria" id="AEB46548">
        <property type="protein sequence ID" value="AEB46548"/>
        <property type="gene ID" value="VAB18032_27376"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27376"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_11"/>
    <dbReference type="OMA" id="YPLHGQD"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="7">
        <location>
            <begin position="19"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="8">
        <location>
            <begin position="291"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="374" mass="39704" checksum="E15F2D3867DA0F6A" modified="2011-06-28" version="1">MTDVSIDAAETRLRRTPLAERHTALGAKFAPFGGWEMPLEYAGGGVLREHTAVRTDVGVFDVSHLGKVRVTGPGAAEFVNACLSNDLGRIEPGRAQYTLCCDEATGGVVDDIIAYLYADDHVFLIPNAANTAEVVRRLRAAAPPQVTVTDEHEAYAVLAVQGPRSADLLDALGLPTGHEYMSFSPATLDGVELTVCRTGYTGERGYELVVPAADAVAVWDALFAAEPTPQACGLAARDTLRTEMGYPLHGQDLSLEISPVQARTGWAVGWDKPAFWGRDALLAEKAAGPTRTLRGLTVAGRGIPRPGMAVFHGDTQVGTVTSGTFSPTNKQGIALALIDTAPALPDGTELQIDIRGRHTPAHLTRPPFTHPSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2V9</accession>
    <name>F4F2V9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27486"/>
    <dbReference type="EnsemblBacteria" id="AEB46570">
        <property type="protein sequence ID" value="AEB46570"/>
        <property type="gene ID" value="VAB18032_27486"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27486"/>
    <dbReference type="eggNOG" id="ENOG502ZKU6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023913_1_0_11"/>
    <dbReference type="OMA" id="VWATHAS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="451" mass="47796" checksum="CC5CFB0ADF0D8BC8" modified="2011-06-28" version="1">MLAVAAFLGGALPDGDLRPDPVKIWLGPNGPWIIGLWLFGTIAMAVAWWVLRDRVPSARWALTTAALWILPFLVTPPLGSRDAYAYACQGASYANGISPYEYGVSTLPCPWLDTMSYIWRDTPAPYGPLFVVISGAVVAATGSLLGSIALFRVLAVAGVVLTAACLPVLARRCGVPVGRALWLALASPLVGVHLISGVHNDAMMVGLMVAGLAIVVTWPGRTWHLLAGGVVLGLAAGIKVTALVVVPFAALAAIPNGFSLRGLLRDGTPVVGGAVATLFGVTLAAGLDLGWITGLSHGNEVIAWTSPPTAVGQTIGYLALPFGLHIDALPVTRGIAMVVLAALLVWLWFRARYREPLWHAALALTAAVALAPLFHPWYWFWPLVLLAATAHRTWWFSAVTVYSAFHVLADGTGLPRHTKTIGAPLMTLFVIVVAVRLVRSARATRRPVPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F328</accession>
    <name>F4F328_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03625"/>
    <dbReference type="EnsemblBacteria" id="AEB47807">
        <property type="protein sequence ID" value="AEB47807"/>
        <property type="gene ID" value="VAB18032_03625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03625"/>
    <dbReference type="eggNOG" id="COG3593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336868_0_0_11"/>
    <dbReference type="OMA" id="CVLPMGG"/>
    <dbReference type="OrthoDB" id="1769482at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="206" mass="22450" checksum="31001FCB541143B7" modified="2011-06-28" version="1">MEVRIEVTALRDARAVLLVEGTSDLVAVQTLAQRRGRDLTGEGVRVLAMGGATNIGHYLEQLGPRGRDLRLAGLYDVAEEGFVRRGLERAGLGVAPLSELGFHVCVRDLEDELIRALGTDGMQEVLAAEGDLRSFRLFQRQPAQQGRELPAQLRRFIGTRSGRKEAYARLLVQALDLERVPRPLNAVLASVTPPGGASPARQHRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F357</accession>
    <name>F4F357_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03770"/>
    <dbReference type="EnsemblBacteria" id="AEB47836">
        <property type="protein sequence ID" value="AEB47836"/>
        <property type="gene ID" value="VAB18032_03770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03770"/>
    <dbReference type="eggNOG" id="ENOG502ZDRK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2107989_0_0_11"/>
    <dbReference type="OMA" id="AIEREWP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046251">
        <property type="entry name" value="DUF6284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19801">
        <property type="entry name" value="DUF6284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="115" mass="12578" checksum="3A3489922EB31B1E" modified="2011-06-28" version="1">MVAVPSIPCLLRRCLLFLVGTAALPIDSTRRFPVRKHLVAVTAEPTAADLAAIDTEWPLIAAELDVLDAQITLIYAEDHGGPSPLDWRRLRRAEARVTRAAADLADRTTDPRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F368</accession>
    <name>F4F368_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional DNA primase/polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736479.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03825"/>
    <dbReference type="EnsemblBacteria" id="AEB47847">
        <property type="protein sequence ID" value="AEB47847"/>
        <property type="gene ID" value="VAB18032_03825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03825"/>
    <dbReference type="eggNOG" id="COG3378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057861_2_0_11"/>
    <dbReference type="OMA" id="TRAWGGY"/>
    <dbReference type="OrthoDB" id="1173531at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="8"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="31455" checksum="C68B0BFEFAE10AC4" modified="2011-06-28" version="1">MSDLLATALGHAERGWHIFPLRPGDKRPAFPDHPADRCAGRDRRCRAAGQHVGWEDRATTDPDRIRRAWSTRPYGIGIACGPSGLVVVDLDTPKHPAEADGRDGLAVLADLADTHGATIDPTYTVTTGRGGTHLYYQHPNTGPALRNTAGTVGPMVDTRAAGGYVVAAGSIVAGRPYVVALDCDPDPLPAWLAGMLAPAPLPPQRPVVVDLPTDRAGAYVRAAVGREVDRVTAAAPGERNRTLYVAAVALGQLVAGGALAADDAQSVLEQAGVTAGLRTAEAYRTVRSGLTAGARRPRAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3E1</accession>
    <name>F4F3E1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731536.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08735"/>
    <dbReference type="EnsemblBacteria" id="AEB42865">
        <property type="protein sequence ID" value="AEB42865"/>
        <property type="gene ID" value="VAB18032_08735"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08735"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_3_0_11"/>
    <dbReference type="OMA" id="RYSGPDY"/>
    <dbReference type="OrthoDB" id="1227369at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="339" mass="35700" checksum="A0785ACF35BB3CF1" modified="2011-06-28" version="1">MTATATSAHSELTELGRSETALRTFLHGLPGVDQVGAEQRAAQLGTRSIKTTAKAQAIDLAIRMVDLTTLEGADTPGKVRALAAKALRPDPADPSCPHVGAVCVYPSMVPYAAEVLRGSGRPSGGAAPAGVHLASVATAFPSGQAPLEVKLADTRAAVEAGADEIDMVINRGAFLAGRYREVYDEIVAIKEACGGDDAGRQGRPRAHLKVILETGELGTYDNVRRASWLAMLAGGDFIKTSTGKVPVAATLPVTLVMLEAVRDFRAATGRQVGVKPAGGIKTTKDAIKYLVMVNETVGPDWLDPDWFRFGASSLLNDLLMQRTKLTTGVYAGPDYFTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3L3</accession>
    <name>F4F3L3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="12" type="ordered locus">VAB18032_15045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15045"/>
    <dbReference type="EnsemblBacteria" id="AEB44121">
        <property type="protein sequence ID" value="AEB44121"/>
        <property type="gene ID" value="VAB18032_15045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15045"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015485_1_0_11"/>
    <dbReference type="OMA" id="CTVEAAQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="11">
        <location>
            <begin position="9"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB44121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="676" mass="70830" checksum="868CD1B8B9790B4F" modified="2011-06-28" version="1">MDGSPVARVCVDVPLPHLDRPFDYLVAHGLGEDARPGVRVKVRFAGQQVDGWLLERLDHSDHPRLAYLEKVVSPVPVLAPEVLRLARAVADRYAGSLADVLRLAIPPRHARVEKEFLPRTDATAPPTPPAEPVSASTGAVSTSVGPPMPAVAADGPVGPVEPGGWRDYPAGPALLRALADGRPARAVWSALPGEDWAARYATAVAATVAAGRGALVVVADGRDLDRLDAALTATLGPDRHVCLSAALGPARRYRAFLTARHHDAPVVIGTRAAMFAPVARLGLVAIWDDGDDLHAEPRAPYPHAREVLLTRAQLDEAAALVGGYARTAEAQLLVETGWAREVVAAREVLRARAPAVAPTGDDPQLARDPAAATARLPSLAWTAAREALRAESPVLVQVPRRGYLPSVACDDCRTPARCVHCAGPLALPSAGGTPACRWCGRVAAAYACPHCGGRRLRASVTGARRTAEELGRAFPGVPVRTSGREEVLADVPGGAGLVIATPGAEPVAEGGYGAVLLLDTWALLTRADLRAGEEALRRWAAAAALARPAADGGRVVVVADGALAPVQALLRWDPAWFAARELAERRELGFPPAVRMASLTGAPDAVADLLAQARLPEEAQLLGPVPADGDRERMLVRVPRARAAALAEALHAAAGVRSARKAADPVRLQVDPLAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F410</accession>
    <name>F4F410_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-amylase</fullName>
            <ecNumber evidence="7">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_27916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735306.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27916"/>
    <dbReference type="EnsemblBacteria" id="AEB46656">
        <property type="protein sequence ID" value="AEB46656"/>
        <property type="gene ID" value="VAB18032_27916"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27916"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013336_0_0_11"/>
    <dbReference type="OMA" id="FRYAYDL"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313576" description="Alpha-amylase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="10">
        <location>
            <begin position="39"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy_C" evidence="9">
        <location>
            <begin position="394"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="482" mass="53176" checksum="C4DB505DA1401A6D" modified="2011-06-28" version="1">MHRRRLRTAIVALGTITTLLAPTVVTAPPAVAAPTGGKKVIANLFEWNWPSVASECASTLGPKGYGYVQVSPPQEHVRGNQWWVAYQPVSYRIESRKGTRDQFRSMVATCQAAGVKVIVDAVINHMSGQTNGGTGWAGSSYQHHVYPGIYQAQDFNYCGRNGNNDIVNYNDRYEVQNCELVNLADLKTGSDYVRSRLAAYLNDLLSLGVDGFRLDASKHMPAADIANILSRLNRRPYIVQEVIYGAGEPIRPEEYTGNGDVHEFRYGKDLARVFRSERLAYLRNFGEGWGHLPSGVSSVFIDNHDTQRDDGGVLTYRDRGIYALANAFMLAWPYGSPTVMSSYTYSSRDAGPPSDSSNKTRNTVCYSGWECEHRWPVIANMVGFRNATEGTGVSNWYDNGYQHIAFSRTGKGFITINDEDFAVNSRSYYTGLPAGRYCDVIHGTFSAGTCSGPVITVDTNGWFTANVPAHDAIAIHLSARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F431</accession>
    <name>F4F431_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_28021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735327.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28021"/>
    <dbReference type="EnsemblBacteria" id="AEB46677">
        <property type="protein sequence ID" value="AEB46677"/>
        <property type="gene ID" value="VAB18032_28021"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28021"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="IRFGGHV"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="28808" checksum="A122D5227A8268E7" modified="2011-06-28" version="1">MLPVMSIPPPAGRAEGPAIQVRNLEKSFKQLPVLRGVDLDVARGSIVALLGSNGAGKTTLVKILATLLRADAGTARVNGFDVAGQAGQVRESISLTGQFAAVDQILTGRENLVLVARLRHLADPGAVADDLLRHFSLTEAANRRVATYSGGMRRRLDIAMSLIGNPPVIFLDEPTTGLDPQARIEVWQTVKELAGGGTTVLLTTQHLDEAEQLADRIAILHQGRILVEGTPDELKRLLPAPEVEYVEKQPSLEDVFLALVGTATEKADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4D8</accession>
    <name>F4F4D8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase s8 and s53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_08890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08890"/>
    <dbReference type="EnsemblBacteria" id="AEB42896">
        <property type="protein sequence ID" value="AEB42896"/>
        <property type="gene ID" value="VAB18032_08890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08890"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1805382_0_0_11"/>
    <dbReference type="OMA" id="MGENYSR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="3">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="143" mass="14497" checksum="3E937924383F17AF" modified="2011-06-28" version="1">MGENYSRSNGTSDATAIVAGAAALVRAKYPYLPADEVAHRLTATAIDKGPPGRDDQYGYGVIDLVAALTADVPPRGFESVPATSPDVAGPTTAAADGPPAGVGGAATVRGLVTLGLLVAGGVAWALVVRHRRRSDDPPPRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4T2</accession>
    <name>F4F4T2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gp41 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732888.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15560"/>
    <dbReference type="EnsemblBacteria" id="AEB44224">
        <property type="protein sequence ID" value="AEB44224"/>
        <property type="gene ID" value="VAB18032_15560"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15560"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2002934_0_0_11"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13547" checksum="12073AD68696D111" modified="2011-06-28" version="1">MPATVAKALKAFQTQQKKERLKAGDAYVDSGYVLVNEIGEGQRTDWLRRRVYDLMAKVGVRKVRPYDARHACLTYLAAAGVPDVVLAAWAGHADGGTLAKRVYVHPDSSHLKVAAEHLESGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4U2</accession>
    <name>F4F4U2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Siderophore-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734084.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21655"/>
    <dbReference type="EnsemblBacteria" id="AEB45431">
        <property type="protein sequence ID" value="AEB45431"/>
        <property type="gene ID" value="VAB18032_21655"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21655"/>
    <dbReference type="eggNOG" id="COG2375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040923_1_1_11"/>
    <dbReference type="OMA" id="HPTMWVR"/>
    <dbReference type="OrthoDB" id="1630289at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="26230" checksum="9CD67523494F43A8" modified="2011-06-28" version="1">MKRNWEALVLKAFGGRSFQLTVLDNEPVGDHYQRLLIDGGDLLQTCGVHPTMWIRLWFNNEGRSHQRAYTLVDPDADSGHFYLVFALHDGCAARWAMSARPGDTIEATVQGSSFTLPDPAPARLYLVGDAASLPAINSLLDAAGPASATAWLEYAHEGEQVLSLHTRPHDEAVWVPRRDNGSHLVDTVTAALSAADDEALYWVTCEAASTRSIVKHLRRRLGVDKEKVEALAYWRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4V9</accession>
    <name>F4F4V9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NarL family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_21740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21740"/>
    <dbReference type="EnsemblBacteria" id="AEB45448">
        <property type="protein sequence ID" value="AEB45448"/>
        <property type="gene ID" value="VAB18032_21740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21740"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="MHEDEDS"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="219" mass="23470" checksum="625FF8A886FB7F39" modified="2011-06-28" version="1">MSREQPERPIRVAVVDDHPVFRLGMTALLGTLIGIECVGEAVDVDSALDLVAGHLPDVVLMDLHLGDRSGVEATRLIRARHPEVAVLVVTMFDDDDSLFGALRAGASGYLLKGAAPQQVERGVRAVANGELLLGPEIGARAVGFFVRGAAPVPFPQLTDREREILDHVAQGLDNATIAHRLALSPKTVRNHLSNILVKIGVGDRAQAIVRAREQGLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Z0</accession>
    <name>F4F4Z0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_21895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734132.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21895"/>
    <dbReference type="EnsemblBacteria" id="AEB45479">
        <property type="protein sequence ID" value="AEB45479"/>
        <property type="gene ID" value="VAB18032_21895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21895"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_113_1_11"/>
    <dbReference type="OMA" id="LWATAFQ"/>
    <dbReference type="OrthoDB" id="1293707at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="627"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="850" mass="89311" checksum="413D162FD05F28AA" modified="2011-06-28" version="1">MPRGELRIYLGAAPGVGKTYAMLEEAQRRAERGIDVVIALVETHGRPHTAAMIGDLEVIARRTATYRGGTFQEMDLDAVLARHPAVAVVDELAHTNVPGSRHAKRWQDIQELLDAGISVLSTVNIQHLESLNDVVAQITGTTQRETVPDQIVRAAAQVELVDMTPEALRRRMAHGNIYPPDKIDAALGNYFRVGNLTALRELALLWLAGTVDEQLDAYRAQQGISATWEARERVVVALTGGPEGATLIRRAARIAARSKGTDLLAVHVARNDGLAGADPAHLARQRVLVESLGGTYHQVLGSDIPAALLDFARGVNATQLVLGASRRGRFAQVLSRGVGVTTTALSGPIDVHLVTHPEAGRGRRTAGVPALSRRRRLLGFTLAVLGMPVLTASLKALPDLTLTSDILLFLAAVVGVALVGGLWPALLAALGGSLLLNWFFTPPFATLTIAGADNLLALAVFVGVAVAVSGVVDMAARRTRDAARASAEAQTLATVAGSVLRGQRPLTALLDRLRETFALRAVSVLELVDAADGRPDRAREEAAWRLVASVGDAPATSPGAGETAVPVDDRLTVVLCGRRLAASDRRVVEAFAAQAAVALRQQRLAAQAAAARPLAAADRMRTALLAAVSHDLRTPLASAKAAVSSLRSHDVEFDAADRDELLATADESLDRLGRLVANLLDMSRLQAGALGVHAVAIGVEDVVPRALDELGPPAAGVRTDIPADLPAATADPGLLERVLVNIVANALRHSPPHRPPLVTASAHAGLVELRIIDHGPGIPADQWEHVFQPFQRLGDRDNTAGVGLGLALSRGLAEAMGGSITPETTPGGGLTMVLRLPAAASVTAMEEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F591</accession>
    <name>F4F591_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ordered locus">VAB18032_28511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735422.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28511"/>
    <dbReference type="EnsemblBacteria" id="AEB46773">
        <property type="protein sequence ID" value="AEB46773"/>
        <property type="gene ID" value="VAB18032_28511"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28511"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_3_2_11"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="104" mass="11074" checksum="7B7F44BC5AD9585D" modified="2011-06-28" version="1">MYAIVKTGGKQYKVAEGDVIEVEKLVGAPGDAVKLAAVLLVDGDDLVTDAAKLAQVEVSGEIAAHTKGPKIRIHKFKNKTGYHKRQGHRQPLTQVKVTGISSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5E2</accession>
    <name>F4F5E2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G-D-S-L family lipolytic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731645.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09280"/>
    <dbReference type="EnsemblBacteria" id="AEB42974">
        <property type="protein sequence ID" value="AEB42974"/>
        <property type="gene ID" value="VAB18032_09280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09280"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050180_0_2_11"/>
    <dbReference type="OMA" id="YRVWAHA"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="68"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="265" mass="26805" checksum="4BCED16DE983BF6A" modified="2011-06-28" version="1">MNSTGGRLAGWLARTAAASLLAGTIGGAAVLAGQAVVARSRRYAQPELGLALRATVGRTGAPQLRLVLLGDSSALGVGVDRLGDTIGGQLAELLAEGPAGRQVRLSSVGVSGSRSTDLATQVARALLGEQPDVAVILIGANDATTLRRPADAAAYLGAAVHRLRQAGVEVVVGTCPDLGAVRAIAPPLRQVVGWVGRQVGRAQTKAVLDAGGTVVDLAAETGQVFRADPGTFCHDGYHPSADGYRVWAHALLPAVAAAAAVSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5H6</accession>
    <name>F4F5H6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731679.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09450"/>
    <dbReference type="EnsemblBacteria" id="AEB43008">
        <property type="protein sequence ID" value="AEB43008"/>
        <property type="gene ID" value="VAB18032_09450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09450"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101758_0_0_11"/>
    <dbReference type="OMA" id="WHLDVQY"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="21338" checksum="D62E13FA593C8294" modified="2011-06-28" version="1">MSTPPVLTGPSLQHDDGWAALHADALAVLTDWQPTSAEAATARDRTLDLLAAGTTAMSRTHRAGHVTASALVFDATGTEVLLCLHGKMGMWVQLGGHCEPGDRTLAGVALREATEESGITGLWMDPVPIDVDVHSVACQGGSLHYDVRFAVFAPPAAVAQVSAESEELGWFPPDQLPHPLAGGTARLVAPGRAAFRRACPRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Z1</accession>
    <name>F4F5Z1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type branched-chain amino acid transport systems periplasmic component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_22250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22250"/>
    <dbReference type="EnsemblBacteria" id="AEB45550">
        <property type="protein sequence ID" value="AEB45550"/>
        <property type="gene ID" value="VAB18032_22250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22250"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668921_0_0_11"/>
    <dbReference type="OMA" id="MEFLRFD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="26"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="411" mass="45006" checksum="220F72D9BBF392A1" modified="2011-06-28" version="1">MTTPQSRAAALIAATNDATVGAGEALTIGLLTPVTGPGDATAGELIVRAACLGAEYLNERGGVRGGLPVRLVLQNDQPQEEGEIMQRSAVGGLAKLALVDQVHAVIGQWHLRTAPGVSAAAELFGVPLFVENGHSTLTQQRRRTLFRTYFTIADRAPMIADLLVEQGVRKAGILAADTVFGLMNADTIADELTARGVEVLRFDFPQDTTDDVRDQLRAVKDFAPDVLINGGVVRTNYMIIQQAAEVGLLPGPMLVVLFPFPMRSQDYWRLAGEVGNHVIWPALLYRPSWPGLTEIGRWFTERYAERFGSFPPDNALNAFTDVTILGQAADAASELSREALIEALETHEFDTWRGPVRFQRDDQHWHHSPPPIVLMQYQQVGQTFDEATIVYPPEARTGTLTRPDHDAQVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F631</accession>
    <name>F4F631_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">ndk</name>
        <name evidence="4" type="ordered locus">VAB18032_28561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735432.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28561"/>
    <dbReference type="EnsemblBacteria" id="AEB46783">
        <property type="protein sequence ID" value="AEB46783"/>
        <property type="gene ID" value="VAB18032_28561"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28561"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_11"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="15218" checksum="720B748CA4BB8D15" modified="2011-06-28" version="1">MSSSSPDERTLVLIKPDAVRRGLVGEIISRFERKGLRIDAMVSRTMDAALADEHYAEHVDKAFYPPLKAFMTGGPLVALVLSGDQVIDVVRGLIGATDGRKAAAGTIRGDLSLSNRENLVHASDSADSAKREIALWFPELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F665</accession>
    <name>F4F665_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="3">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="3">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="3">HAD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nbaC</name>
        <name evidence="4" type="ordered locus">VAB18032_28731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735466.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28731"/>
    <dbReference type="EnsemblBacteria" id="AEB46817">
        <property type="protein sequence ID" value="AEB46817"/>
        <property type="gene ID" value="VAB18032_28731"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28731"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_11"/>
    <dbReference type="OMA" id="NARKDYH"/>
    <dbReference type="OrthoDB" id="1591291at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="PTHR15497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="174" mass="19653" checksum="AD57D362BAEB163F" modified="2011-06-28" version="1">MSEIAEPFSFPGWIAENQHLLKPPVGNKEMFPGSDDFIVMVVGGPNQRTDFHVDPYEEFFYQVKGNMHINLMTPQGPRTVHVREGQMWMLPRNVPHSPQRPEPGSIGVVVERVRPEGTLEKFQWYCPECGHKVHEVELQVRDIAADLPPVFGAFYADETARTCDNCGTLHPGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F672</accession>
    <name>F4F672_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">kmo</name>
        <name evidence="7" type="ordered locus">VAB18032_28766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735473.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28766"/>
    <dbReference type="EnsemblBacteria" id="AEB46824">
        <property type="protein sequence ID" value="AEB46824"/>
        <property type="gene ID" value="VAB18032_28766"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28766"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023210_0_1_11"/>
    <dbReference type="OMA" id="REFMFIA"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="6">
        <location>
            <begin position="7"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="444" mass="48176" checksum="A0DEDE9E261650C7" modified="2011-06-28" version="1">MNTRQDEIAVVGAGLAGCLLACYLARRGHSVTLYERRPDPRVGTPERGRSINLALSERGLDALRRIGLDEQVMADALPMRGRMVHPVVGEPDFQSYSAEGDRAINSISRGALNNALLDAAAKLPQVRVAFDHRLVGLDPATAQMTFETPQGTVTANATVVLGADGAGSAVRGQLLEHGLLTESVDFLDYGYKELTIPPLGGDFALDPGALHIWPRGTSMMIALPNPDRSFTCTLFWPNHGTASFSSLGSKAAIERYFAQHYPDLPPLAPNLVDDYQHNPVGVLGTVRCDPWQFDGRVGLLGDAAHAIVPFYGQGANCAFEDVVELDTCLDECGDDWAAALPLYQQRRQDNAEAIAQMALANFVEMRDKVASPVYQTRKKVEHALERALPGRYVSQYELVSFTTVPYAQVRRRVRRQYQVLGAVAAGAAAVLAGAVLALGRRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F680</accession>
    <name>F4F680_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28806"/>
    <dbReference type="EnsemblBacteria" id="AEB46832">
        <property type="protein sequence ID" value="AEB46832"/>
        <property type="gene ID" value="VAB18032_28806"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28806"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_14_1_11"/>
    <dbReference type="OMA" id="VFAQREY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="449" mass="46928" checksum="BF79BEC1DF9D0E04" modified="2011-06-28" version="1">MEAMVSDERPPPEGPATFREVFAQGEYRAIFLANTLTWIGDYVAKAAVTLLVYKETDSVALSAAAFAVSYLPWLIGGPLLATIAERHRYRQIMVICDLIRMALMLLIAIPGMPVPLILALLFATTLANPPSQAARSALMPLILPGDRLVVGLSINASVGQAAQVVGYLLGAAVATVNTTAALLMNATAFAVSAVLVRFGTRDRAPAIASEHRRHLLRETAEGFRLVFRTPVLRAIAILVFGAMLCSIVPEGLAAAWANERADSGMNAGMAQALIMASSPVGFILGGLLMGRAVAPSRRIALLRPLAVIAPLMLVPSLLDPPPVVVALLAAACGFAVAGILPVANGLFVQALPHGYRARAFGVMATGVQVIQGAAVLATGLLAEHYPIPIVVGLWSAAGVVLMAFVARRWPDAQTVEATVEAARASSAGSATPSQEPGQGNVDRPRHAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6E9</accession>
    <name>F4F6E9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD linked oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731766.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09885"/>
    <dbReference type="EnsemblBacteria" id="AEB43095">
        <property type="protein sequence ID" value="AEB43095"/>
        <property type="gene ID" value="VAB18032_09885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09885"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048432_0_0_11"/>
    <dbReference type="OMA" id="YIPSRHY"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="PTHR10801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="460" mass="52065" checksum="15ED719D95C5D62A" modified="2011-06-28" version="1">MHAVRDHDLAVAQLRRSYEAVPPGQPVRLAKRTSNLFRPRNAPRTPGLDVSGLDGVLGVDPVARTAEVQGMCTYERLVDATLAHGLMPLVVPQLRTITLGGAVTGLGIESTSFRNGLPHESVIELDVLTGAGEVVSARREGEHADLFAAFPNSLGSLGYATRLRIELQPVRRHVALRNVRFTDLSELTAAIGQITASRSWDGEPVDALDGVMFSPDEAYLVLGTFADDVPAVSDYTGQDIYYRSLRRRQRDALTCYDYLWRWDTDWFWCSAAFGVQHPVVRRLWPTRWRRSDVYHRIVRLEHRHQVAARIDRWRGQPPRERVVQDVEIPLERTAEFLHWFADRVRMSPVWLCPLRLREPTGAGSARSWPLYPLRPAQDYVNIGFWGTVPIAEGAADGDVNREIERAVSEVGGHKSLYSDAYYDRDSFDRLYGGDTWRAVRDRYDPEHRLTGLYEKAVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6K6</accession>
    <name>F4F6K6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16140"/>
    <dbReference type="EnsemblBacteria" id="AEB44334">
        <property type="protein sequence ID" value="AEB44334"/>
        <property type="gene ID" value="VAB18032_16140"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16140"/>
    <dbReference type="eggNOG" id="ENOG50322XD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2002935_0_0_11"/>
    <dbReference type="OMA" id="IRREWAN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13981" checksum="D3AB06F712E1A76B" modified="2011-06-28" version="1">MLTVLTRPTTTLGRKRPQGWRVVRRQARCAAGAIPQTGGSTPHHRWGYAIRRDWPDGTHDLFAFTPDKDTAERNLTRDHTYWRSGPVRPAAVFIVAAHTTDVDHHPVDGCRNPSCPHTPQRGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6K7</accession>
    <name>F4F6K7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid permease-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16145"/>
    <dbReference type="EnsemblBacteria" id="AEB44335">
        <property type="protein sequence ID" value="AEB44335"/>
        <property type="gene ID" value="VAB18032_16145"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16145"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_20_1_11"/>
    <dbReference type="OMA" id="ARYVFAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="484" mass="49034" checksum="062F1C90CACFDA16" modified="2011-06-28" version="1">MTAHVQVALARRTLTPAALWMFGAAASAPMVVLVGGITAIYATTGVTALPLTFLLVAATMAILAVGYTTMARHIGHPAAYYGILAHGLGRGWGVAGGAVALIAYNAIQISLYGLLGATMATHLGGTWWVWAGIAVTVVAVLGVRAIVLSIRVLAVVLTVSLLIVAAFVIAGTTQPADSLSWAGFHTSGLMVGGIGGAIAFCVAAFTGIDAPGSFVEEAVDRRAIGRATIVGALALGGVYATTAWAMGVAVGPYAIADLAAPPDSNLPFTILGRLGDGWVATAALMLIFAILTSKLSFHCVIARYVFAMAREGVLPTRLAGTDHGTRINAPRGGSLTQTATAALVVAGFAVAGLDPLTQMFTWLSSLAAVGLLSLLLAASVATLAAPPHIRGDRPRAWEWRIAPAVGVVTGAIVLIAMIGNIGSLLGAAPGSLFPLLLPAIILGAAIVGGAWAAYLRHTRPQTYAGIGRGIPAANAVPDAITISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6L1</accession>
    <name>F4F6L1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44339">
        <property type="protein sequence ID" value="AEB44339"/>
        <property type="gene ID" value="VAB18032_16165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16165"/>
    <dbReference type="eggNOG" id="ENOG503395D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1124161_0_0_11"/>
    <dbReference type="OrthoDB" id="2030151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="27722" checksum="74C0704E508A122C" modified="2011-06-28" version="1">MIQVPLAGKVVFVDWHSVLSRDPFWMSIRESATHPLKAQLEANLAEVFKSKANEWMKGLLSSEEIIKSMDVELDGRFREDFLTRRLYVDCAKMRVNAELFEALRKIKSHVLVVLATDNMDCFLRTFDRARAKRRRPTPQSETLADWAVILDDIICSSEVAALKAEVPQRFFGPWLAEHGLTFADAALIDDRADNCAAFTEQGGKAVQYKMGIGDVHDVLESLTTWMESGSVAPTAGTSWATNLPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6Z5</accession>
    <name>F4F6Z5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28941"/>
    <dbReference type="EnsemblBacteria" id="AEB46859">
        <property type="protein sequence ID" value="AEB46859"/>
        <property type="gene ID" value="VAB18032_28941"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28941"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061176_0_0_11"/>
    <dbReference type="OMA" id="TWFLGRA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="245" mass="26788" checksum="821B5DC35F886116" modified="2011-06-28" version="1">MYRDWPLKPLSEHSELLYCPPDADPDYGTDTEDGPTRYGYQKAGCEAAAVTAFGADRTTILRPGVVLGPREYVGRLPWWLRRVAAGGQVLAPGSPARTIQPVDVRDLAAFALHTIAEGSSGAFNVCAPVDGATFGGLLADCAHATQADATFDWVPDEVLLNQGVRQWSELPLWRTFDGVWRVDTTKAQATGLRCRPLSLTVRDTWRWMVESGEVSSHDRAAEIGINPEKEAQVLAAWHRSGERTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F4F765</accession>
    <name>F4F765_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11 12">Xylose isomerase</fullName>
            <ecNumber evidence="4 11 12">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xylA</name>
        <name evidence="15" type="ordered locus">VAB18032_29291</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11 13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="4 11 12"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735577.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29291"/>
    <dbReference type="EnsemblBacteria" id="AEB46929">
        <property type="protein sequence ID" value="AEB46929"/>
        <property type="gene ID" value="VAB18032_29291"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29291"/>
    <dbReference type="eggNOG" id="COG2115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060750_0_0_11"/>
    <dbReference type="OMA" id="HKFTFGL"/>
    <dbReference type="OrthoDB" id="481478at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013453">
        <property type="entry name" value="XylA_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02631">
        <property type="entry name" value="xylA_Arthro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="14">
        <location>
            <begin position="41"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB46929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="395" mass="43270" checksum="1E15866D9F55BF05" modified="2011-06-28" version="1">MAPRPTPADKFSFGLWTVGWQGRDPFGHATRTAIDPVESVHRLAELGAYGVTFHDDDLIPFGSDAATRDAQIARFRKALDETGLVVPMVTTDLFQQPVFKDGGFTSNDRDVRRFALRKVLRNVDLAAELGAKTFVMWGGREGAEYDVAKDVQAALERYREAVDLLCQYVIDRGYDLRFALEPKPNEPRGDILLPTVGHALAFISTLAHPERVGLNPEVGHEQMAGLNFAHGIAQALWQGKLFHIDLNGQRGVKYDQDLVFGHGDLLNSFALVDLLEHGGPAGAPAYEGPRHFDYKPSRTEDLDGVWASAEANMRTYLLLKERAAAFRADPEVAEALAASKVAELGVPTLGEGEGYAELLADTSAFEEFDVDAVAARGFGFVRLNQLAVEHLLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F799</accession>
    <name>F4F799_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731828.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10195"/>
    <dbReference type="EnsemblBacteria" id="AEB43157">
        <property type="protein sequence ID" value="AEB43157"/>
        <property type="gene ID" value="VAB18032_10195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10195"/>
    <dbReference type="eggNOG" id="ENOG5032HID">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1553505_0_0_11"/>
    <dbReference type="OMA" id="TAPRWPR"/>
    <dbReference type="OrthoDB" id="1884371at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="19350" checksum="79BC1003DFA173CF" modified="2011-06-28" version="1">MRVDEQSTDPIDQILGELPVPTPLTPEDVRLAVRAVVVHAAEEWPSGALCRNDGSRFPCRLHRWGRQVLLNHGLNERQLDALIRHGNPFVHVPFPFLVNGPNPGRTPAARPSGGDRTASHPGRTADRAAGYPPRQGLAAGYPARGPVPRVAAPPVRAGARTAGTGRPVAPPATAPRWPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7G7</accession>
    <name>F4F7G7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16510"/>
    <dbReference type="EnsemblBacteria" id="AEB44406">
        <property type="protein sequence ID" value="AEB44406"/>
        <property type="gene ID" value="VAB18032_16510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16510"/>
    <dbReference type="HOGENOM" id="CLU_2412364_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="92" mass="9920" checksum="1C9B5F110FC84BC3" modified="2011-06-28" version="1">MSYWAAGASWGTGRNRSAAPVASSALIGPHGYLLRRAKSDGPDVVCVDLDRTDADLDIALNKARPWRAAARAGDIYATRRVTDARSLDRTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7W7</accession>
    <name>F4F7W7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29356"/>
    <dbReference type="EnsemblBacteria" id="AEB46942">
        <property type="protein sequence ID" value="AEB46942"/>
        <property type="gene ID" value="VAB18032_29356"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29356"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911981_0_0_11"/>
    <dbReference type="OMA" id="RAPYHEP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="305" mass="32305" checksum="1E2F8C690B0C157F" modified="2011-06-28" version="1">MRQQEQLNNDHAETVRSTPVPVTDNDHATDEFDGTDEFDGTDERGARAEAGADRNRPWDGRPGDDDERAEFHDPGPVPTAFGATSVGGAVAASALANPRPENEPDPRAERTARPGDGAVDGEREGLRADPTAEFGGRHDEIDPAEVTEADDVARDAGTHRADRSDEVDEDRSPGTDTAAAAAGGAGYGSATPAMVDPDTQSATGVAANGSTAAVPAGAATLFDDTTAQGFRDRWRDVQLRFVDDPRAAAGEAQTLVDEAMQALSTALTQHKEKLGSWQEAGATDTEQLRVAVREYRDFLDRVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8B8</accession>
    <name>F4F8B8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10805"/>
    <dbReference type="EnsemblBacteria" id="AEB43279">
        <property type="protein sequence ID" value="AEB43279"/>
        <property type="gene ID" value="VAB18032_10805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10805"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="422"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="509" mass="53495" checksum="7F00BF4713B8DD82" modified="2011-06-28" version="1">MMHQHGIGVWMAKRRLKSPDKVALVHGEGSTLTYAQLADATDRVAAVLRDQGVGKGDAVAYLGENSPEFLQVMFGAAQLGAVFVPVNTRLAAPEIAHVLDDSGARVLIHDPEFAPRVAAAVPAARTPHVVVTGDGDADRPGLARLARTAATDAAGPVATDHGDPAAIVYTSGTTGRAKGAVLTHGNLTWVAINCVVDYDVVSTDVALMISPLFHVASLGMGALPVILKGATMVLEKGFEPGRALAQIERHGVTMLSGVPTTYQLMADHPSWTSTDLSTLAKLTCGGSAVPPRILNAYEARGLSFSQGYGMTEASPGATSLPPHMTRAKQGSVGLPHFFTEVRITDVSGEPAPTGSVGEIEIAGPNVFPGYHGLPEATADAFTPDGWFRSGDLGYLDSDGYLHISGRLKDMIISGGENIYPAEIEQLLGELEGVTAAAVIGVPDERWGEVPWAIVTVRDGAAVDVEAVRAYLDGRLARYKLPKNVIIVDELPRTASGKVRKADLRARFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8I3</accession>
    <name>F4F8I3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17120"/>
    <dbReference type="EnsemblBacteria" id="AEB44528">
        <property type="protein sequence ID" value="AEB44528"/>
        <property type="gene ID" value="VAB18032_17120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17120"/>
    <dbReference type="eggNOG" id="ENOG50325Q2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2453791_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="89" mass="9760" checksum="84970C59EC1854E7" modified="2011-06-28" version="1">MLDALVTFRNNPRFAASDPAEIADQHPVVAQTLDIAQDIVVELGKEVLIEALFPGAHLLVPPHDFVDSLCTAVEMLEVAEDPAESLWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8K0</accession>
    <name>F4F8K0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Beta-lactamase</fullName>
            <ecNumber evidence="2 4">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_23225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23225"/>
    <dbReference type="EnsemblBacteria" id="AEB45743">
        <property type="protein sequence ID" value="AEB45743"/>
        <property type="gene ID" value="VAB18032_23225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23225"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031960_6_0_11"/>
    <dbReference type="OMA" id="EWMKGNA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023650">
        <property type="entry name" value="Beta-lactam_class-A_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00118">
        <property type="entry name" value="BLACTAMASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00146">
        <property type="entry name" value="BETA_LACTAMASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307510" description="Beta-lactamase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="7">
        <location>
            <begin position="75"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="309" mass="32489" checksum="C5DFFA0A3A39E21A" modified="2011-06-28" version="1">MFSTTRRTRAGVLAAAVTAALLTACSTDTPAAPASPDTSSATPPGTPSAAPVAVDFGPLEQEFDARLGVYAVDTGTGRTIEHRADERFAYASTFKALAAAAVLKATTAEELDQVVRYSRDDLVTYSPITEQHVATGMTLRAIADAAVRYSDNTAGNLLFDRLGGPAGFKQALRDIGDDVTEPARIETALNAATPGDVRDTSTPRALATSLRAYAVDDALPTEDRDVLVDWLKRNTTGEKVIRAGTPDGWVVGDKTGSGGYGTRNDIAVIWPPDREPIVLAVLSSRDAEDAGTDDALLARAAELTLNALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8N5</accession>
    <name>F4F8N5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734430.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23400"/>
    <dbReference type="EnsemblBacteria" id="AEB45778">
        <property type="protein sequence ID" value="AEB45778"/>
        <property type="gene ID" value="VAB18032_23400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23400"/>
    <dbReference type="eggNOG" id="ENOG50301CN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180737_0_0_11"/>
    <dbReference type="OMA" id="WDSFHRV"/>
    <dbReference type="OrthoDB" id="2095829at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="73" mass="8060" checksum="028FD6FFA1E61B04" modified="2011-06-28" version="1">MSEVTVRFVGGPAHDLVRELPAGPDGAPPRLWVLRRPEAAPTPAADHLYARQRPDGTVWTMRYVRTDPVGVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8P5</accession>
    <name>F4F8P5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45788">
        <property type="protein sequence ID" value="AEB45788"/>
        <property type="gene ID" value="VAB18032_23450"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23450"/>
    <dbReference type="eggNOG" id="ENOG50305HV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2246921_0_0_11"/>
    <dbReference type="OMA" id="CYPVSLW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="98" mass="10777" checksum="3B46EE87BB81E27F" modified="2011-06-28" version="1">MMKRIVEIVPARPGWYARWRLAPENTRCYPVSLWALLEDADGTGREVIGVDCAGQWPGDGGTDAEFVRYLFQTPDSGLPDDAEPMPEARRAGSVVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8T3</accession>
    <name>F4F8T3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">argS</name>
        <name evidence="13" type="ordered locus">VAB18032_29711</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735661.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29711"/>
    <dbReference type="EnsemblBacteria" id="AEB47013">
        <property type="protein sequence ID" value="AEB47013"/>
        <property type="gene ID" value="VAB18032_29711"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29711"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_0_1_11"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="430"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB47013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="554" mass="60549" checksum="9A4BC713EFFA4A92" modified="2011-06-28" version="1">MTPAELAEAVLAAAHAVFADRGLDRSALPEQTTVERPRNPDHGDYASTLALQLSKKVGVPPRELAGDLAAKLGSTPGIKSVEIAGPGFLNIRLDAAAAGQLARTIVTAGEEYGRGDVLAGLKINLEFVSANPTGPVHIGGVRWAAVGDALSRLLRAAGADVGTEYYFNDAGSQIDRFARSLLAAAKGEPAPEDGYGGAYIAEIANEVTARRPEVLSLDEDAAQEVFRVEGVELMFAEIKSSLRDFGVEFDTYFNEKDLHDRGELEHALNRLREQGHIFEADGATWLRTTDFGDDKDRVLRKSNGEWTYFAADCAYYLDKRERGFDRVVIMLGADHHGYIGRMKAMSACFGDDPAQNLEILIGQLVNLVRDGAPVRMSKRAGTVITLEDLVDAIGVDASRYALARYSSDSPIDIDIELWTRATRDNPVYYVQYVAARTASVGRNAAEVGLTRGDVDAFRPELLDHDKENELLKALAEFPAVVAAAAELREPHRVARYLEDLAGAYHRFYDNCRILPRGDEEVTDLHRARLWLNDATRVVIANGLRLLGVSAPERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F948</accession>
    <name>F4F948_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PASTA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04750"/>
    <dbReference type="EnsemblBacteria" id="AEB42076">
        <property type="protein sequence ID" value="AEB42076"/>
        <property type="gene ID" value="VAB18032_04750"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04750"/>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1209383_0_0_11"/>
    <dbReference type="OMA" id="LYPRYAT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="94"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="158"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="23699" checksum="31BFB612E03F07CA" modified="2011-06-28" version="1">MTGEVTDGRTTRADTGPDRKTMVVGGGVAAVLLAVIGAAGGWVLAGDEQRQPETPVAAKGGRSPSAPAPSTPRERPASTSAPTSAAPTSAAAPSPTGLTVPDLVGMDLEEARNEVRKRGLEWKFIFGTGDNQSVRSTDPVAGTPVKHGSTISITVAGAAPLNEMPQVVGEDCREAAAELFDKGFSPHYPSGLTGKVTEQEPAAGTVGRWDDIVYIFCGIRSSDDEFLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F963</accession>
    <name>F4F963_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_04825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730765.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04825"/>
    <dbReference type="EnsemblBacteria" id="AEB42091">
        <property type="protein sequence ID" value="AEB42091"/>
        <property type="gene ID" value="VAB18032_04825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04825"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_0_11"/>
    <dbReference type="OMA" id="MWAPVTG"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307524" evidence="1">
        <location>
            <begin position="29"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="160"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="501" mass="52716" checksum="57DA4811B8BEF233" modified="2011-06-28" version="1">MNAPLRRVGVVVIVLFGLLFANLNWIQAYKADEYRTSDYNSRVQVAEYERRRGNIEAGGTALAVSKETDGKLTFLRTYPGGAKYAHVLGYKPVNLADTGIEKSENDFLAGTSDKLFANRIKDMFTGDRTAGGNVLLTLSPRAQDVAYDQLRNNNRGASKGAAIAIDPRTGAVQAMVSIPSFDPNPLASHNTNEAVAAYNKLDQDRSRPLRNRALGEVLPPGSTFKIVVAAAALENGIGKDTNISAGPSYTPPTSGQSITNAAPSICPQAEVTLMKAVTDSCNTGFAKLGVQLGPDAIKKKAQDFGFEQEDLTVGRLGEGGHGVAASRTGTMENPDGGPDPAALAQSSIGQRDVRMTPLEGAMIAAAVANGGSQMRPYLVRQLLAPDRTTVYDTANPRELRRPVSGQVAADLREMMVSVVRNGTGRNAQINGYTVGGKTGTAQSAPDRPDHGWFIGFALDSDGNPVSAVCVVLEEAGSGGSAEAARIAGQIMRAAIADPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9D5</accession>
    <name>F4F9D5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_11055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11055"/>
    <dbReference type="EnsemblBacteria" id="AEB43329">
        <property type="protein sequence ID" value="AEB43329"/>
        <property type="gene ID" value="VAB18032_11055"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11055"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_11"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="15"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="379" mass="39873" checksum="60CFBC7C90063DFE" modified="2011-06-28" version="1">MLDEALEAYVVAAREVGNASSLHASGRRARRRVEESRERVAAALGARPSEVIFTGGGTESDNLAVKGIFWARRDADSRRRRVVSSAIEHHAVLDAVDWLERHENAEVGWLPVDEVGRLHPDALRAELAEHGDQVALITAMWANNEVGTVQRIADLAAVAVEYGVPFHTDAIQAVGQVPVDFAASGVAALTVTGHKLGGPVGVGALVLARDVAAVPLLHGGGQERDVRSGTLDAAGIVAFAVAVETAVKGQQEYAARVAALRDDLVQRVRQAVPEVVYNGDPDDRLPGNAHFSFPGCEGDALLLLLDAQGIYCSTGSACSAGVAQPSHVLLAMGADDDRARSSLRFSLGHTSTSADVDALIAALPGAVERARRAAQRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9I0</accession>
    <name>F4F9I0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733213.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44558">
        <property type="protein sequence ID" value="AEB44558"/>
        <property type="gene ID" value="VAB18032_17280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17280"/>
    <dbReference type="eggNOG" id="ENOG5033R4W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1214356_0_0_11"/>
    <dbReference type="OMA" id="WAINIAY"/>
    <dbReference type="OrthoDB" id="2119280at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24122" checksum="E85FD830EC532E65" modified="2011-06-28" version="1">MTPEPCTDGTFRHLSVDLHPVGGGDDGMTGYTLCSAPQRPVRGDDQAAIDVPYDAYRTDTHVDIAALPPCGECLRVAALLADPETAPPLHRSPRPDLPSELTGEVIRRLLDTDIATGAPPGRRAAVHLLTFTAVPDQPGFADLVERLSLLWGADGTVEMGQVRDWEAVVRFAATADVPDRDRQMIALAASLAGRPSVDLDAAASFVDDPAAARRVIEAIAIASGDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9W9</accession>
    <name>F4F9W9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734547.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23985"/>
    <dbReference type="EnsemblBacteria" id="AEB45895">
        <property type="protein sequence ID" value="AEB45895"/>
        <property type="gene ID" value="VAB18032_23985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23985"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009955_0_0_11"/>
    <dbReference type="OMA" id="HASVAHQ"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="621"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="869" mass="91975" checksum="9FF7602E147794D6" modified="2011-06-28" version="1">MPDSTAAGAGIAALALDTVQRRPREAITIAQRVLTTRHVDDDARSTAERAIGLALRELNDLTGALHHLRRAVRAAESARTRALARMSLGYVLATAGRTSAALRAVTAALPELTGADAGRARMQRGVVLHYRGRYDEAVRDYGLAIDIAQRAGDLLLEARARNNRGLLNAHRGGNGDVDDLTRAASIFGELGLDLAAADARWNGGIAAGRRGDIAGALRRFAAVGEEYHRLAVPRPALLLDRFELLLSVPLVDEATEVAAAAVDELRRRGMASDLAEALLAQARAALLAGDLDTATEAAAAARTRFRRQGRRIWAAFARHVELRAEFRRGTRTAALFAAMVRTADQLDATGWPDPAQLTRIDAGLLASALGRVDRAAQLFGTVARTRGRGTAPRRAQGWYAQALWHRLRGDEAAAARALRRGLAVLDRHRTSLGATELRANSGAYGQELAAEGLDIAVRAGAPARVLAWAERWRATALRNRPALPPDDAELVTALAELRLVSGLLEDAVLTGRPVRVLRGRQARLEHRIRDLTRLVTGATTTPAPPRVGELADRLGPRVLVELFVHGDRLGAVVVADGRASLHDLGPSAEATRLARWHRFGLRRLIVTGDSTAARTGAAHAAAALDRQLFDPLRRRLADRPLVIVPVGALHAVGWAGLPTCAGRAVTVAPSATAWLAAARQQTWAGTPTLASGPRLPAGAVEVKRLAEVLPTARLLTGSNATAEALTAALDGAPMVHIAAHGTFRADNPQFSTLELADGPLFAYEWERIARPPGCVVLSACESGLSGVRPGDEIMGFAAVLLALGTRCLIATVLPVPAEPTTELMVDLHLRMHAGAEPAQALAAAQRAFVATGDHTASATAAAFVCLGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAC2</accession>
    <name>F4FAC2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="8" type="ordered locus">VAB18032_05285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05285"/>
    <dbReference type="EnsemblBacteria" id="AEB42183">
        <property type="protein sequence ID" value="AEB42183"/>
        <property type="gene ID" value="VAB18032_05285"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05285"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_4_0_11"/>
    <dbReference type="OMA" id="DGRHHTF"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="340"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="411"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="425" mass="45369" checksum="F83DFBA91507857D" modified="2011-06-28" version="1">MNGLMTGRDGLDDEHTIVVDLGYGDAGKGTVVDWLCATRPVHTVVRFNGGAQAAHNVVLRDGRHHTFAQFGAGTFHPGVWTHLSRHVVVDPLALAAEADHLADVGVPDALDRLTVDGEALLATPYHRAANRARELSRGADRHGSCGLGVGEAVAYGLAHPDEAPRVADCRSPKRLRRRLTALRDRLTAELGPLDAPPVDDCLPAFTAFAERVAVVDRSWLAGALRAGPCVFEGAQGVLLDEWHGFHPYTTWSTTTFANAESLLTEAGQAGAASRLGVLRTVTTRHGPGPLVTEDPTLPLTDPHNPTNPWQGRFRFGHFDAVAHAYALAAAGGVDGLALTHLDLAERGLDLRICRRYEGLDRLLPGPPGDLDRQAALTARLLRARPVYDDDSPTDWPQAVGEALGAPVVLTSHGPTAADKNLLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAC6</accession>
    <name>F4FAC6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_05305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05305"/>
    <dbReference type="EnsemblBacteria" id="AEB42187">
        <property type="protein sequence ID" value="AEB42187"/>
        <property type="gene ID" value="VAB18032_05305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05305"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056696_1_0_11"/>
    <dbReference type="OMA" id="YPHVLGF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="271"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="373" mass="40094" checksum="BDA36DAD8FC2B8DD" modified="2011-06-28" version="1">MARRSPHEEPSDDLSVGELIDGPTEALTPEILAAAFADERRDLDATQDLSSAAARVGAGPDPGVTQDLTSAAASVVGPAAASEAGQPAARARVELSRLPAPGPLYRRALLGTLPGLGGRRGADVPAVELAVGGVAVDPQRLADYDRVCGFRLADTLPATFPHVMGFPLALRLITAPEFPIPPTGVVHIGNRITVHRPITVTDRLDFTAWAENLRPHDRGRQVDVVLVGSVDGEEVWHGVSTYLWRQRTPGDGERRDRAEPPAPPAASARWRVEPRIGTEYARVSGDHNPIHTSRLGARLLGFPRPIAHGMWTKARCLAALESRLPEAYTVQVAFKLPVSLPSTVAFSADRQGDDWDFALHDQRGRPHLVGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAI9</accession>
    <name>F4FAI9_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_11510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732086.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11510"/>
    <dbReference type="EnsemblBacteria" id="AEB43416">
        <property type="protein sequence ID" value="AEB43416"/>
        <property type="gene ID" value="VAB18032_11510"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11510"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097062_2_0_11"/>
    <dbReference type="OMA" id="AYATWQA"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="19775" checksum="18AC8AEC1C455D63" modified="2011-06-28" version="1">MTWTAPAIDRRNEPYRADERTMLEGWLNYHRDTLLLKCAGLTGEQLRTASVSSSTLTLLGLVRHMTVVERWWFRQCFAGESLPELYDFDADPDAEFNTVDSADPEADLAAFRAEVTAADAATAGHDLDEVCTVKRRTGTEEISLRWIYLHMIEEYARHNGHADLIREAIDGVTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAL9</accession>
    <name>F4FAL9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_17660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733289.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17660"/>
    <dbReference type="EnsemblBacteria" id="AEB44634">
        <property type="protein sequence ID" value="AEB44634"/>
        <property type="gene ID" value="VAB18032_17660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17660"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_7_0_11"/>
    <dbReference type="OMA" id="FVEMTII"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307571" evidence="2">
        <location>
            <begin position="27"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="44"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="426" mass="44881" checksum="F3D085F4A629CD8E" modified="2011-06-28" version="1">MRTTERRGLAIATTLTLLLTLTACGSDDGPGAGEPVPGVTDTEIVVGTHMPLTGPASAGYSKIAPATKAYFDYVNANGGVHGRKITYKVMDDGYNPATTQQVVRQLVLQDKVFAVLNGLGTPTHTGVLDFLHTNRVPDLFVASGSRNWDQPDRYPNTFGFNPDYTVEGKILANHVKTTLPGRKVCFLGQDDDFGQDALAGVEKVLGTDGVVARETYVTSNTNVAPQIGAFKAAGCEVVILATVPGFTALSVGTAARLGFRPQWVVSNVGADHPTLARQLGDAAGLLEGMVGLNYLPMQGDTDNPWIQLFTKVNTEHNGGAEFDGNTVYGMAVGYLFVQVLLAAGKDLTRESLVEAVRKGGYQGPGVAPLRFSATDHSGYGGGRLSRVSGGKQSYFGPTYETDEADGPVNEYTAPPVSPPVNGVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAU8</accession>
    <name>F4FAU8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734563.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24065"/>
    <dbReference type="EnsemblBacteria" id="AEB45911">
        <property type="protein sequence ID" value="AEB45911"/>
        <property type="gene ID" value="VAB18032_24065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24065"/>
    <dbReference type="eggNOG" id="ENOG5033NHD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112913_0_0_11"/>
    <dbReference type="OMA" id="REGYYTA"/>
    <dbReference type="OrthoDB" id="1970247at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="19772" checksum="04DA7C0DA2209E01" modified="2011-06-28" version="1">MGNLVAQLPALIGVLVGTIGTIVATSLADRARWRRRQGVRWDERRLDAYAEFARALKEVHTIASRLIGGYLDREQELALLTEANFRHTIAWENVLLLGDAPTVTAARAWRDAVWEVERLARDGSATDGLPDLLHRANEARDQFYDAARGGLGVSGGSVAQAALLVDRLYPRHSRPPAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB07</accession>
    <name>F4FB07_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LemA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_24360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24360"/>
    <dbReference type="EnsemblBacteria" id="AEB45970">
        <property type="protein sequence ID" value="AEB45970"/>
        <property type="gene ID" value="VAB18032_24360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24360"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_2_2_11"/>
    <dbReference type="OMA" id="VETQYQR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="187" mass="20254" checksum="3ED5ED0CA6421B6B" modified="2011-06-28" version="1">MSIAGGVFCLLAVLVLGWVLVAYNRLVRQRNQVQASWAQIDVQLKRRYDLIPNLVETVRGYAAHENAALTGVIAARSGAIAVAGAAAVVHRAEAENTLTQALGRLFAVAEAYPELKANQNFASLQGELARTEDKIAYARQFYNSAVLTFNTTVQSIPTNLVANLGGFRPTEFFQADGAERAAAQVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB64</accession>
    <name>F4FB64_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein LuxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_00625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735854.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00625"/>
    <dbReference type="EnsemblBacteria" id="AEB47209">
        <property type="protein sequence ID" value="AEB47209"/>
        <property type="gene ID" value="VAB18032_00625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00625"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="NVLRKTQ"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24949" checksum="36FBF803127377D1" modified="2011-06-28" version="1">MAEQSTPPVEPNDAGAQRLRVFLVDDHAMFRAGVRAELGTHVEVVGEASTVAEAVSRIAATEPDVVLLDVHMPDGGGRAVLEAMRRSHPQVRFLALSVSDAAEDVIGLIRAGARGYVTKTISPDELAAAIRRVADGDAVFSPRLAGFVLDAFAARPDAPVADPELDQLTNREREVLRLLARGYAYKEIARELYISIKTVETHVSNVLRKLQMSNRYELSRWAADRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBA9</accession>
    <name>F4FBA9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glu/Leu/Phe/Val dehydrogenase dimerization region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_05395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730879.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05395"/>
    <dbReference type="EnsemblBacteria" id="AEB42205">
        <property type="protein sequence ID" value="AEB42205"/>
        <property type="gene ID" value="VAB18032_05395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05395"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_0_0_11"/>
    <dbReference type="OMA" id="TYVADMD"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="6">
        <location>
            <begin position="147"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="183"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="360" mass="38203" checksum="8A3E6FEF325B0162" modified="2011-06-28" version="1">MGVFASTDDPESTGHEQVVFCEDKQTGLKAIIGIYSTALGPALGGTRFYPYASEEEALADVLDLSRGMAYKNALAGLDLGGGKAVIWGDPAQIKTEALLRAYGRFVESLGGRYYTACDVGTYVPDMDVIARETRYVTGRSVEHGGAGDSSILTAWGVFQGMRAAAEHVWGVPTLHGRRVGVAGLGKVGKYLVGHLVEDGAEVVATDVSPQALEWARTTHPQVSLLDDVSALVAADIDVYAPCALGGALNDDTVAALRAKVIAGAANNQLAHPGVEKLLADRGILYAPDYVVNAGGVIQVADEIEGFDFERAKLRATRIYDTTREILRLADADGVPPAVAADRLAERRMAEIGRLRAIHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBK8</accession>
    <name>F4FBK8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_11780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732139.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11780"/>
    <dbReference type="EnsemblBacteria" id="AEB43470">
        <property type="protein sequence ID" value="AEB43470"/>
        <property type="gene ID" value="VAB18032_11780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11780"/>
    <dbReference type="eggNOG" id="COG0435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_1_3_11"/>
    <dbReference type="OMA" id="YQLFVSY"/>
    <dbReference type="OrthoDB" id="780709at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="168"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="36180" checksum="429E9DFE124F23E3" modified="2011-06-28" version="1">MAGAQFSAETSEAGAFVRQPNRFTGRVTPHSGSPPGAGPDEQDRWPLEPGRYRLIWCRACPWSHRALIVRNLLGLDEAISLGTVDPIRDERGWRFTLDPDGFDPVLGVGFLAEAYLATDPDYTGRVTVPALIDTVTGRVVTNDYPQLTLDLSTEWRRLHAPDAPDLYPVELRPEMDQLMADIHRDVNNGVYRCGFATSQQAYDEAYTALFARLDALSLRLAEQRYLMGDTITEADVRLFVTLVRFDVAYHGHFKCNRRKLTEMPVLWAYARDLFTTPGFGETVDFDHIKRHYYATHHEINPTGIVPLGPDLHGWTTPHGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBX9</accession>
    <name>F4FBX9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative NRPS-type-I PKS fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_18385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18385"/>
    <dbReference type="EnsemblBacteria" id="AEB44779">
        <property type="protein sequence ID" value="AEB44779"/>
        <property type="gene ID" value="VAB18032_18385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18385"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000139_0_0_11"/>
    <dbReference type="OMA" id="MPYFHDM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="575"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1887"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2973"/>
            <end position="3048"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1924"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="3008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="3904" mass="411534" checksum="3BF87AFDF68EBFBE" modified="2011-06-28" version="1">MSTASGPGAHHGLLGVLLDAADRAPQQVIVHVREDGTERTVSFRQLRDESLRVAGGYRAAGIAPGTAALLLADAGDDFQPMFWGALAAGLVPVPLPPEPKRVRAVREVLPDAVLVTDDATAAVVDGLPEPVLRLADLRAGAAPAELPTVAGGDLAFLQFSSGSTGAPRGVELTHDNVLANLDQARSASAARPDDVLVSWMPYFHDMGLIGTHLTPLAIGLKQVRIPPLAFAKRPALWFTTAHRHRATLLSAANFALALAVRRVPAETLAGLDLSAVRCVVVGAEPISPAVWRSFLAHTRPAGLDPAALRPVYGLAEATLAVTFPPPGEVAVPHVLDRAKLSQGRAVPTRPGPHAVELMDLGHPVADCAVRVVDDHGRPLADQRIGQIEVRGPNVARGYHRDPQASRDTFVDGWLRTGDLGFLRAGRLCVTGRAKDVVFVNGRTFHAADLETVAVATPGLPGEVSVVVGATDPDSGGERIVVFVPWARPPADAGTVLAAVRARVAEACGHDEVRVLPLPPGAFARTTSGKLRRRRMRERYLAGDFADRERRWCPPVATEVPHDAPPAADDAPRDAPSGAELEALVRDVWARVLGRPPATIGPHDRFLAIGGSSLKAMEVLAALEDALGIPLNPADLRDCPTVASLADRLADAPLRRPTGDAVGAPAQGPARGPVPVAVIGMACRFPGAESPEQFWQQLVDGVDSVDVVPAHRWTSSDGTARWGSFLDDPMLFDAGFFGLTDEEARLTDPHARLFLEIGHEALERAGYAGPRRHRHRIGVFAAVGESAYPQMVAADGSAGGATALVGNLRNLIPARLAQTLDLTGPAIAVDTACSSALVALHLAARSLAAGECDVAVVGGVNLNLTETGYRLLDAAEALSPTGRCRAFAADADGFVPGEGGAALVLRRLGDAQVDEDEVLAVVAGTAVGNDGRALSMLAPNPHRQWEVIARAYREAGIDPAQVSYVEAHGTGTELGDPVEVRSLAAAYPSPVDGVPRGLGSVKTNLGHLLNAAGLPALVKVVLALRHRYLPPALHHTQPADRCDLAGAGFAVVTQGRRWSAPGPLIAGVNGFGFGGTNAHAILQEPPPTAPTAPGGPELGLVTLSAHSVPALRQAARDLAAHLRAHPHLAEADVCVSAGTARDDAAYRLAMVADGELAVRLDRAADTLGEQIAPVSRRPRTVFVLPDDGATVPPAAVRDLYDRLPAFRDRLTEVAAPTVRGRPLLTWCLSGADDPQVTRQVAVAVGLALVGQFTAWGVRPDRLLGVGVGDLAAAAGRGELDPAEAIRRAATATPRTEPELRVALKQLCADGYDTVVDLGVSGRLHAVSPHVGVDPARVLTVLDGPQATGALLAAVGQLWALGGSLDRAALHAGRRRVPVPTYPFQRRSHPPSPVLPLHRVIWRETPSTSGGPAAGVDRDLPARVRLRGPGADGDLAARLATALRERGVTVQVAPQVDDGTPPELTVLLAGAAVDLSDVADLDRAVAAQVRTVRALIDEPDTRLGRLLVVTEDVQVTGHGERPRPVQAVLGGLCAALADERPGLRARVVDLSSVDDLAVRVESVCQELSDLHRAEATAHHADRLTGLAWRAGRRLERHLVSVSVPVTPSGAAHSDDMHVILGGGGGLGAELARTLAHRGRPTLLLAGRSAQAPAGLLDELTSAGATATYRRCDVTVPADVDALFTGLPRVGTVWHAAGTVRVGTLTAKSVPEIRAVLAPKVRGSYLVAESLLRHGHDRVALVGFSSVSAVLPGLAAAIGDYAAANAFLDAFAAAQRVTGRPFQAVGLAAVSDTGMAAREGSRHDIAGSLTARIALDALLAARDVDAAHLIVADRRPATAPPAGVARRGQDFDGRVQAHAGRPAQPVDPETVEVAEVGGVSAIKPARHQNSDVEELARLLRRLLAEPLHRPADQITDDDSFLALGLDSLAAVDLVKRLEDELGRQLPVTLFFEYTTIATLAAALAETVPGQPPGHQVVPPSRVARPAAGGGSPSGPLADGEPFALTAVQRAWFVNERLHPSVAGYAFVRQTVTGPLDVRLLDRALTGLVARHPMLRVRFLADVTAPRQVIVPPTAAAISLDVRALAGELTALEEQLCNTPVDLTRQPPLRAVLAQERSDRAHLILVLHHAAADGFSLNLLSEQLWADYSALVTGGTRTVLPVTGSFAAFAADLAPPRETDLTWWRRQFDDPGWTLRLPYDGDPAGLPAPPCVTRTDELDAALVALLRERAADAGVSLFHLLLAGYLRCLARWSGQRRVPVNVARAGRDARMPGIERLVGPFADTLPLLVEVDPTEPVARLADRLRQSWTEAQRHGSVSSLDLARLLPAIDNGPRTASPAGFSFARFPVDVDPDCPVTVTPTAAGSGSAATGLSLLWWESGTTLRLSWNFPLRLFRRQTVARLAAEHHQELVDLAAGRQRAGDQDRSVRPEPVAGDVSARIRAVCRRTPDATAITDGRRTVTYRDLDRAADRVAALLLAHGVRPGEHVGLLTAPGRNSIIGVVGILRAAAAWVPLDAAHPPARLDGQLRRARVRVVLHDDDCAATVARLDATAVNLDGPAVPVDSPAAPLDGPAVGPDDTAYVIFTSGSTGRPKGVPITHRSMTNYLDWAIDTFGYHAGDRLAQTSSICFDASVRQILAPLLVGATVVTFARSELRDPQVLLSRLERDRLTVWSSVPTLWERLLRAAEDRTTREGVRPNLLALRWVHVGGEELSPVPVRRWFDLFGDGCRITNLYGPTEATINTTWHLIDNRPDETVRRLPIGRPVGGARIRVVDTHGDPCPPGTAGELLIGGVGVTAGYLDEPALTVAAFTRLDGERYYRSGDRVRVTADGTLEFLGRLDDQVKIHGHRLEPGEIEAVLRTHPAVTAATVLHQAEPHPRLHAFVAPRPGTEPTVAQLREHLADRLPEPLVPARIHLLDTLPLTVTGKVDRDRLRALGGFAPAAGPKRLPTPAAAGRLPATAAPERLAAPVGADAAAGGYTATEARLARIWGELLDLPAIAPDDDFFALGGDSILVLEVFARVQDQFPATPSPTVIYQHRTLRDLAAEIDATTARRRTTDGTGRSTATVDRVTGPVRAGADGPYPVTATQRGFLLADAIAPGDGTAWLARLRLRGRLRRDVFQRAVDLLVARHPMLRTVFPAGVRPPVQQELPASLRLPVGYRAVAGPAEVGTLVAEERRRRFEPWAWPLLRLQLLGLAPDDHILLVHGHHLIGDGYSAALLGQELLTVYHRLVADQPDGLPPLRTHFRDYVELLADRVAGPPDPDAHGWWRGRFGTPYRPPVLPAPGSAPDPGGTSAPVCGFTLDGTVVAGLRRLAASAASTLYAPVLTAYHRAVARFTGQDDLVFGLALTGRDHPLPDLHRIFGPCAAMLPLRLGGSAGFAEQLAHVGAEVATARRYDDPPSIAAAVPTGPGGTPIGAQFFFSFLDFSARSAPPAVPGDADRLSLDWDADSELAPPPLGTDLFLTARPERDGLRLTLRGCPTTVTPAELRRLADWLRADLTAAAHTDPARRDQTATPAVVTGDAASVPATTAVPGRPTRLAAAIVGYLPPPAQLAAIAGLPAGSLPRDQLRELLFPGGRPRLLEQLTTPLGVSGFVCLPRFADELTAAGDVLADETAEAVDLAARLGARCVSLAGMIPARTGYGLGVLRRTRSGVAVTTGHAVTVVSVVRTVQAALAATGRSLAGRDLAVVGLGSIGFSALRLLLIRAEQPPARLVLCDVPAAAPRLGEHAARLRADGFAGTIEVCPSAPGIAPAGYTADVIIAATSAATAPIEVDRLAPGTIVVDDSFPPALDTAKALTRMRRDHDILVVGGGLLHVGETERDIPGDLPPVPVDGNVLGLAGTIASCRLESLLWSTAADLPLVHGLVDDATAAAYARALTEAGIDAAPLHLLHHPIGSELLGRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBZ7</accession>
    <name>F4FBZ7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24485"/>
    <dbReference type="EnsemblBacteria" id="AEB45995">
        <property type="protein sequence ID" value="AEB45995"/>
        <property type="gene ID" value="VAB18032_24485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24485"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="OMA" id="EVAWAKS"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="5"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="30552" checksum="8DE4CE6A7CB2FD2D" modified="2011-06-28" version="1">MHEYGDASVIRADDVPRPVAGPGEVVIKVAATSFNPSDVGLRRGLLRAVFTADLPYTLGGEVAGTVVEVGAAVPTLDVGDPVIGRIDGGGAAAEYVTAAAENLVAAPTTIPLAHAAAVPIAGVTAWQAVFDHAKVIAGQRILVNGAGGGIGGFTIQLAKHAGAYVLATASPRSADAVRRLGADEIIDYLATPLVDALDEPVDTVVNLVAGSARQAGMLLPLVRPGGLVVSATVPVRPPAGSSVTAVHFVARNDTDQLAALVALIDAGKVQVDIAAVRPLAELAEVHREAESGQTRGKIILVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC51</accession>
    <name>F4FC51_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24755"/>
    <dbReference type="EnsemblBacteria" id="AEB46049">
        <property type="protein sequence ID" value="AEB46049"/>
        <property type="gene ID" value="VAB18032_24755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24755"/>
    <dbReference type="eggNOG" id="ENOG502Z8YF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860368_0_0_11"/>
    <dbReference type="OMA" id="FFDPFGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="34874" checksum="B5FB2F8F3577BF8A" modified="2011-06-28" version="1">MRPGLVTHAARLPETRSMTLTYLGNSPYCAANSLSILFGDEGPGPAVLEIAGGSPFGLAIHGDDIIYFSSPAWRPEFGINNAMELAGWECDRIHGSPTDAVAVLRQATWDKPVLAGPVEMGLLPYVPGLGQAVGADHNIVVIGVEGDTVRAHDVIGWPFVTVGVDALLKTWEGNTFAYEADAYAVRFNFRRVREVDRETVLRAAMHTAVDLLSAPGIPEAAERAAQLVEGDLKSMQYKYLVEFQVQAGARRLADAAMLYRRLGSHGPAEILERQALLVGSLQLDLMTQEYGRAAATFRALGPTYAELRQAFVEAIDDQPGPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC99</accession>
    <name>F4FC99_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PKD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_00970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735922.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00970"/>
    <dbReference type="EnsemblBacteria" id="AEB47278">
        <property type="protein sequence ID" value="AEB47278"/>
        <property type="gene ID" value="VAB18032_00970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00970"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002470_2_0_11"/>
    <dbReference type="OMA" id="RLIRIEY"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309227" evidence="3">
        <location>
            <begin position="41"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="4">
        <location>
            <begin position="717"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="911"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="4">
        <location>
            <begin position="1061"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1559" mass="165127" checksum="7AA9AF888DA93118" modified="2011-06-28" version="1">MPRTRRRRATPGLFTVALLALVLVLAGAPAPVTGPAAAQAAGRTAAAAAADPYSVLVFSKTAGFRHDSIPAGIRAIQQLGTANNFTVVTTEDGGAFTDTNLARFKAVIWLSTTGDVLNASQQSAFERYIRAGGGYVGVHAASDTEYDWAWYGQLVGAYFNSHPANQTATVKVEDYAHESTRHLPERWSRYDEWYNFRTNPRARQVQVLASLDERSYSPGSGAMGHDHPIAWCQGYDGGRSWYTGGGHTQESFSDAAFLQHLLGGIQTAAGVVHSDCGAGRAASFEKVTLDSNTSNPMELDIAPDGRVFYIERDGRVQIIKPDTGQTVTALRLSVFAGNEDGLLGIRLDPNFASNGWVWLYYAPSAGGSRNYLSRFTVTGDTISASSERVVLEVPTQRNTCCHMGGTMTFDSAGNLYLATGDNTNPFESSGYSPLDERSGRADYDAQRTAGNTNDLRGKVLRIRPQADGTYTIPSGNLFAPGTARTRPEIYAMGLRNPFRIGVDPVTNVLYVADYGPDATTTNANRGPEGLVEWNIVDRPGNFGWPYCHGNNQAYNDYQFPSGPSGAKFNCSAPVNNSPNNTGLTNLPAAIPATVDYGYGGNSRFPEIGGGGAPMAGPVYRFDPTISSRRQWPAYFDGKSIFGEWNQSRMYTMQVSKDGKTLVDINRILDQMTFVRPMDMEFGPDGALYLIEWGSGFGGNNDNSGVYRIDYTAGARAPIAVASANPTSGAPPLAVSFSSAGSRDPDGGALTYAWTFGDGGTSTQANPTHTYTRSGSYTAQLRVTNPAGRTAVANVPITVGNTAPTVTIEFPPDGGFFAWGDQVAYTISVTDPEDGTIDCADVELQVLLGHDEHAHPLERHTGCTGTVQTQLADGHGADANVFTVLEATYTDKGGSDGAEPQTGRALKILQPKRKEAEYFSATGRVAGATGGGTAGVEKETTGDTAGGGQNIGWIEDGDWWSVTPASLTGVTSIQFRVASATSGGRIEVRAGAADGPLITTATVAGTGGWQTYTDVTAQIPNGASSEGGLYFVARDPNRGTGTLFNVNWMNFVGPGVSGNAPPTVTATGTPTSGTAPLAVTFTGTATDPDGDTPLTYAWDFGNGATATTLNATATYTTPGNYIATLTVTDSRGARAQATVPIRVDGTGGNEPCQVQQGPLRSDEFTGTSLDRQRWSGVVRDNQSLSVSGGALRLPTAAGDLYGTRNDATNLVLQPAPSGAWQATTRVTVAARADYQQAGLILYGNDDNYAKLDLVYGGNRKVEFIRETSGTPRNDSADATAAPTGDTIQLRLTSDGTNLTAAYSTDGQTFTPVGRSAALAGITNPRIGLFALNGGTTAPVVNAEFDWFRITPEATTGTSTAPSDEFTGSTLEKCRWNAMVREDATRYRVTDGALRIDVPNGDIYGTSNTGPTNFILQNSPAGNWTIQTRVDGSLFNEQYQQAGLLVYADDDNYLKFDYVTDNAAGQTISRRIEFRSEVGGAVQSTQPQATGLTQGIWHLRLTRSGSTYTAAYSADGTSWTTLGSLTSTAVGTTPKVGLFTLGANQTASKTAAFDYFRLTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCA9</accession>
    <name>F4FCA9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsD</name>
        <name evidence="10" type="ordered locus">VAB18032_01020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735932.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01020"/>
    <dbReference type="EnsemblBacteria" id="AEB47288">
        <property type="protein sequence ID" value="AEB47288"/>
        <property type="gene ID" value="VAB18032_01020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01020"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_2_11"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="23777" checksum="A45F037D7534425A" modified="2011-06-28" version="1">MARYTGADCRRCRREKMKLFLKGSKCDGPKCPFESRPFPPGQHGRGRTKETEYLLQLREKQKARRVYGVLEKQFRGYYEEAVAKQAKTGEVLLQILESRLDNVVYRAGYAKSRDMARQLVKHGHFTVNGKKVDIPSYRVSAHDIIEVRAKSKELTPFIVAQAEAGSKTVPAWLEAIPSQMKVLVHSLPARQVIDTQVQEQLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCP1</accession>
    <name>F4FCP1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cdp-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_12105</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12105"/>
    <dbReference type="EnsemblBacteria" id="AEB43535">
        <property type="protein sequence ID" value="AEB43535"/>
        <property type="gene ID" value="VAB18032_12105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12105"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_0_11"/>
    <dbReference type="OMA" id="WSMVYYL"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB43535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="203" mass="21664" checksum="DB1A4D717407C98E" modified="2011-06-28" version="1">MPERGPMTGATESTPAPVAARVPVVNAANGLTALRLLLVPVFAASVIVSGMTHAGWQITACLIFAVASATDLVDGWIARRFGLITAVGKVADPIADKALTGAALLLLSWYDRLPWWVTGLILARELGITALRFWVIRRGVIAASRGGKVKTALQILAIVWYLWPMPDGLAVIGPWIMGAAVVVTVVTGFDYIAQALRLRRARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCX0</accession>
    <name>F4FCX0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18500"/>
    <dbReference type="EnsemblBacteria" id="AEB44802">
        <property type="protein sequence ID" value="AEB44802"/>
        <property type="gene ID" value="VAB18032_18500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18500"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473220_0_0_11"/>
    <dbReference type="OMA" id="PQVIPVH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307632" evidence="2">
        <location>
            <begin position="19"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="576" mass="57808" checksum="2361FF47EBE00FCB" modified="2011-06-28" version="1">MLLAVLLIPVAAQAQATAAVPEETGKYYVVGPPVDGQRDYLYSIALRTLGNGNRFREIIELNRGREQPDGATFTDGVELAPGWILVLPKDADGPGVRTGRLPAIRPPAPRSTPSPSTPSPRAGSPSPTLLPPSPSLPPPAPGGAAPPPATAAPAGDPTAPADRTPWIQAAPSKLADAAPDLVRVGAGALALVLAVVAILVLPRRAYRMRSATLDDGPWPPQRHHTPTPAELAANSDTPPASPPGSPAFPPAPPASPPDPPVPSPAPRASSPNPPASAPDAPVGSVSAAQPSPTVAVPMTPSAAPGRSTPAGPPPSARPDPAKTAASPDPGPGPASSTPPAEWPPIAAPPSTASAAPSAAVPETPPGTPTTALPATTSAAPVATKRPTTADEGGSARPALPGEGEVPYVRTNLATDLGPILVRLVGVTTGPTTAAYAWLADDEPVPAATVPLVLGRRGPWRLQIDLRRAPDVFTLVGVMDDCRRLAATYARQLREAGVAVAVVGDALGAEPPDGCRRLATWAAADDLGPEPYVVIGAGVPTDGGAGLPGLAAGSRGRCIPLVIGAVPYGRWSAQLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD62</accession>
    <name>F4FD62_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734744.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24970"/>
    <dbReference type="EnsemblBacteria" id="AEB46092">
        <property type="protein sequence ID" value="AEB46092"/>
        <property type="gene ID" value="VAB18032_24970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24970"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057011_2_3_11"/>
    <dbReference type="OMA" id="GEAHVWW"/>
    <dbReference type="OrthoDB" id="1542506at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="3">
        <location>
            <begin position="120"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="279" mass="30677" checksum="CE9F15A804E3B719" modified="2011-06-28" version="1">MSAPGKPVWVDVGTPPGTDVWHIVLDVEREIVDPFIALLDADEMRRAHRLRDEQAAHRFVAAHGAVRSVLGSYLDVAGYALHWARGPNGKPYFDGEWRRWQWSLSRSGGHALLAVRLHEPVGVDVEQIRDDVRAGALAARFMPPEEAAEVAAQPDDATRNAAYHRLLSRKEACVKASGGRLLDGLRLGVLVPGIVEGSGAFVGQRWSLRDLPAPPGFVATLATVGDRPRRLRMFEWDWRGYPYGARTDGPTGQPPDRPEITRPPGDEDSSPPDLSRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDB5</accession>
    <name>F4FDB5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ordered locus">VAB18032_01210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735963.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01210"/>
    <dbReference type="EnsemblBacteria" id="AEB47326">
        <property type="protein sequence ID" value="AEB47326"/>
        <property type="gene ID" value="VAB18032_01210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01210"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_2_11"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="129" mass="13710" checksum="0334B741145149A0" modified="2011-06-28" version="1">MAKLSTEELLDAFKEMTLIELSEFVKQFEETFEVTAAAPAAMMMAGPAAGGAAAEAEPEKDEFDVVLDADGGKKIQVIKVVRELTGLGLKEAKDLVESAPKAVLEKVNKETADKAKAKLEGEGAKVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDV1</accession>
    <name>F4FDV1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732300.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12590"/>
    <dbReference type="EnsemblBacteria" id="AEB43632">
        <property type="protein sequence ID" value="AEB43632"/>
        <property type="gene ID" value="VAB18032_12590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12590"/>
    <dbReference type="eggNOG" id="ENOG5032TUY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070587_0_0_11"/>
    <dbReference type="OMA" id="NLMPFMV"/>
    <dbReference type="OrthoDB" id="1550026at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="28323" checksum="EC5C1BF2F27AEB84" modified="2011-06-28" version="1">MSEWSAGIDDGGADELGTTVAALTADEIEPAKRRQLLGRLVRQARARGVGGLFKPKTALRWMTDTVAQIAPHVPIRDLATLRRHFPDLDDEALADRLVRNAARATAGIGAAGGGASAVQWTVTPTLLSAPVLLAAETVAVVAIELKLTGELHEIYGAPLPASGAQRAVALMQAWANQRGVNPMVPGVGIGAVLGTAARRELRDTLLKRFGRNLTTLGPFLTGAAVASYLNRRATRTLADQLRTDLRRQRRSLPGSPPTVPGPPPALPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE10</accession>
    <name>F4FE10_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbaK/prolyl-tRNA synthetase associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733534.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18885"/>
    <dbReference type="EnsemblBacteria" id="AEB44879">
        <property type="protein sequence ID" value="AEB44879"/>
        <property type="gene ID" value="VAB18032_18885"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18885"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_1_2_11"/>
    <dbReference type="OMA" id="DRQISWP"/>
    <dbReference type="OrthoDB" id="1503081at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="154" mass="16123" checksum="7E0D32B362EB3550" modified="2011-06-28" version="1">MSTPALDALAAAGLRHQVVEHGPVRSLDEAAAALGVAVPDVVKTLVVRRSDDDYLFVLVPGDRVISWPRLRALLGVNRLSLPDADTAKAVTGYERGAITPFGATNRWPVVADERIRGRTITLGTGRHGTAVLVEADAALAALAATLADITDPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEA4</accession>
    <name>F4FEA4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-bound metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734822.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25360"/>
    <dbReference type="EnsemblBacteria" id="AEB46170">
        <property type="protein sequence ID" value="AEB46170"/>
        <property type="gene ID" value="VAB18032_25360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25360"/>
    <dbReference type="eggNOG" id="COG1988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071993_0_0_11"/>
    <dbReference type="OMA" id="PGQEYLW"/>
    <dbReference type="OrthoDB" id="1667936at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="269" mass="28630" checksum="5017C3804A55308F" modified="2011-06-28" version="1">MMGPSHALSGAAVWLSGSWALQQFYDYEQSPLALAVGTAVCAGGALLPDLDLSGKVTRNKGGATVARTFGVFSLFIAEVVEKVSLGVYYATKLSRDPKRNNGHRTLTHTIPFTVLVGWGTTTLCARFGKWAVIGILFFMIGLALRGLFDKWAERAGWLIVTLISAGAAVVTAANLPGDRGYPLIGLAVGVGSFVHIIGDMITRAGVPILWPIPIKRRMWTPISLPDKIALRAGGRTEMAIVRPALTVISILASVGLFAPSLLDKFNIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEF8</accession>
    <name>F4FEF8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YrdC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736035.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01580"/>
    <dbReference type="EnsemblBacteria" id="AEB47400">
        <property type="protein sequence ID" value="AEB47400"/>
        <property type="gene ID" value="VAB18032_01580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01580"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1287636_0_0_11"/>
    <dbReference type="OMA" id="SARWHAV"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="238" mass="26108" checksum="27EE7957D532E05D" modified="2011-06-28" version="1">MSGPDHVFRASDLTPGGSLTTRALSLIVTRLNQGGFVLLPSDTCYSIALVPHNEDSWKFINSLLRRPVDRPVSVAFSGLDQVRGYLELNATALHLVERFTPGPITLVCPANQRAHKFAAKSTGSPDRTLGFRIPDSKIERDVASHARWPITTTAVRDKRDEPVQSFDEALKIVTAAAAAVGSARWHAVEGRDSFYSKHSTVVRVDQSGEVGLIREGDIPFETIRQSTHWLPASDPDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEH6</accession>
    <name>F4FEH6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736053.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01670"/>
    <dbReference type="EnsemblBacteria" id="AEB47418">
        <property type="protein sequence ID" value="AEB47418"/>
        <property type="gene ID" value="VAB18032_01670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01670"/>
    <dbReference type="HOGENOM" id="CLU_2830072_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="66" mass="7377" checksum="485973B97884DEF3" modified="2011-06-28" version="1">MYRYMLTFTHTTSGETQFTALDYPTARPISSVEDVQLVTLHLRTQGYTAPFVIAFSLFTPADKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEQ5</accession>
    <name>F4FEQ5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine transaminase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphohydroxythreonine aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_06625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731122.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06625"/>
    <dbReference type="EnsemblBacteria" id="AEB42449">
        <property type="protein sequence ID" value="AEB42449"/>
        <property type="gene ID" value="VAB18032_06625"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06625"/>
    <dbReference type="eggNOG" id="COG1932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061974_0_0_11"/>
    <dbReference type="OMA" id="TAFWDIA"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006272">
        <property type="entry name" value="Pser_aminoTfrase_mycobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01366">
        <property type="entry name" value="serC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="142"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="375" mass="39532" checksum="C85F86A8C1A46863" modified="2011-06-28" version="1">MADAPTIRIPDEIKPADGRFGCGPSKVRPAAVSALAEVATSYLGTSHRQKTVRDQVARLRSGIAEFFSLPEGYEVIIGNGGTTAFWEVATFGLIRDRAQFANFGEFGAKFAKAVKDAPFLGEPTIRKSDAGSAPTLVAEAGVDVYATPHNETSTGVAVPINRVAGADPGSLLLVDATSGAGGLEVNVGETDVYYFAPQKCFGSDGGLWLALMSPAALERAAEVKASGRYIPAFLDLVTAIDNSRLEQTYNTPALATIFLAAEQTDWMNSQGGLAWAAKRTAESAGIVYGWAERSAVATPFVADPALRSNVVATIDFADGVDATAIAKALRANGIVDTEPYRKLGRNQLRIALFPAVEPADVEALTASIDYVVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFK8</accession>
    <name>F4FFK8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">VAB18032_02005</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02005"/>
    <dbReference type="EnsemblBacteria" id="AEB47485">
        <property type="protein sequence ID" value="AEB47485"/>
        <property type="gene ID" value="VAB18032_02005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02005"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_15_11"/>
    <dbReference type="OMA" id="SYMGDEV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="331"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AEB47485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="426" mass="45732" checksum="79EC17DE1422B9BA" modified="2011-06-28" version="1">MSGEPMTSSGEGDDRLATWKAREAALYRLLPYGGLAVGTLLALLTPAPRGLPIWLTLTVVVAAGAWVAWFINLHPGWQSRRTRMAVYYAGLLTFAAVLVVASPWYGYFAWIGYVHAFPVLSWRWRIGGVAVTAVLLATAQGGGVSAALSGSQLWLVLVLFNVLVAGAVIWFNIVAEREDAKRKRLVAELAAANRQLTETVRENEGLHAQLVTQAREAGVLDERQRMAREIHDTLAQGLTGIITQLEAAEQTRDRSGDWRRHVDNALALARESLTEARRSVRAIRPEPLEAARLPDALTELGGRWSARHGVRAEVNTTGTPRPLHPEVEVTLLRAAQEALANVARHAAASRVGLTLSYMSDVVTLDVRDDGTGFDAEAAAPKPDGGYGLTAMRQRVTEVGGRLDVESEPGGGTAISASVPALPGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFW9</accession>
    <name>F4FFW9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin (3Fe-4S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731222.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07125"/>
    <dbReference type="EnsemblBacteria" id="AEB42549">
        <property type="protein sequence ID" value="AEB42549"/>
        <property type="gene ID" value="VAB18032_07125"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07125"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_0_11"/>
    <dbReference type="OMA" id="CEAMAPE"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="7191" checksum="3E94A8A63110031F" modified="2011-06-28" version="1">MRVRVDFDSCDSNGLCALAAPTVFEVRDDDYLYVLQENPPQELWDEVTQAATACPKLAITLEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFX4</accession>
    <name>F4FFX4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase, FabA/FabZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731227.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07150"/>
    <dbReference type="EnsemblBacteria" id="AEB42554">
        <property type="protein sequence ID" value="AEB42554"/>
        <property type="gene ID" value="VAB18032_07150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07150"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_2_0_11"/>
    <dbReference type="OMA" id="SWAQSAV"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="183" mass="19422" checksum="3F4C7C9F383E197C" modified="2011-06-28" version="1">MNAAEIRAVLPQRHPLLLVDRVTSMQPGDVIETVKAITATEPCYAHLGDDATAEDYAYPASLLIESFGQSAALLWLAGTTGSDRLTDDALLLFVGAREYTVEGRAYPGDVVRHVVRLERVVADTAFATGESWVGQRRIATVGSLMAARRPRSAVAEPAAGPTGAGVDRTIPANTSAQGGRHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFX5</accession>
    <name>F4FFX5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphopantetheine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_07155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731228.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07155"/>
    <dbReference type="EnsemblBacteria" id="AEB42555">
        <property type="protein sequence ID" value="AEB42555"/>
        <property type="gene ID" value="VAB18032_07155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07155"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_7_1_11"/>
    <dbReference type="OMA" id="FKEDHGA"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="84" mass="9741" checksum="4B891F6192477F97" modified="2011-06-28" version="1">MSGENERYEQLREIIAEVLEIETDELTDTGDFAEEYQADSLRAIEILARIDKEFKVEIPQSELPELRNLKATYEAVARHAGWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG97</accession>
    <name>F4FG97_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19665"/>
    <dbReference type="EnsemblBacteria" id="AEB45035">
        <property type="protein sequence ID" value="AEB45035"/>
        <property type="gene ID" value="VAB18032_19665"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19665"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_4_11"/>
    <dbReference type="OMA" id="PPEPIIF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="278" mass="29407" checksum="F4F3A00EE4F69B4D" modified="2011-06-28" version="1">MGAVGQERPAALDRAGRLVDLSGLVSEIDAAFLGGDGMAEVRAAVDGGTLPEADPTARIGAPIARPGKIVCVGLNYSDHAAETGAKPPAEPVLFMKAPNTVVGPNDQVLIPRGSRKTDWEVELAVVIGRTARYLASPAEAWDCVAGYTIANDVSEREFQLERGGQWDKGKSCETFNPLGPWLVTADEVPDPQQLGLRCSVNGILRQDGNTKNMIFGVAEIVHYVSQFMVLEPGDLINTGTPAGVALGMPEPKPYLRGGDVIELEIDGLGRQRQPVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGH8</accession>
    <name>F4FGH8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734964.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26075"/>
    <dbReference type="EnsemblBacteria" id="AEB46313">
        <property type="protein sequence ID" value="AEB46313"/>
        <property type="gene ID" value="VAB18032_26075"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26075"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_11"/>
    <dbReference type="OMA" id="FEDTTAN"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="206" mass="21883" checksum="ADD3A831F8519022" modified="2011-06-28" version="1">MPTNDAAPLRADARRNLTKIMSAAREVVVEHGLDAPMELVARRAGVGVGTLYRRFPTREALLGAVAEAYVADLVTATRRIIDGAADSWSALRELVDWCASPGQGALAAALADLPVAQVQALPAFARSRQEWLDLLDGLVTDGQRAGTIRADIGTGDLVALLTVFTCHPDRLPRHVADQPARYLHLMLDALDATAPRGTPLPGAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGK6</accession>
    <name>F4FGK6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734992.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26215"/>
    <dbReference type="EnsemblBacteria" id="AEB46341">
        <property type="protein sequence ID" value="AEB46341"/>
        <property type="gene ID" value="VAB18032_26215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26215"/>
    <dbReference type="eggNOG" id="ENOG5032S3Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150609_1_0_11"/>
    <dbReference type="OMA" id="RWRYSLM"/>
    <dbReference type="OrthoDB" id="1805024at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="PTHR40630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="16093" checksum="5584F9EAA6FD338F" modified="2011-06-28" version="1">MSGRDDPDQTYREFTEAVNMKPGELSTWLETEESKQVGWRKGGGESVGHQSGRRIIDLLRRKRDQLTEADYKHMRKVVGYVRRHMAQRPSGDVRATRWRYSLMNWGHDPVKAKLPPPGGPSRKALQRHGAPPEARRPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGS7</accession>
    <name>F4FGS7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02515"/>
    <dbReference type="EnsemblBacteria" id="AEB47587">
        <property type="protein sequence ID" value="AEB47587"/>
        <property type="gene ID" value="VAB18032_02515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02515"/>
    <dbReference type="eggNOG" id="ENOG50333S7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067089_1_0_11"/>
    <dbReference type="OMA" id="FAHLEVG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="24494" checksum="B9C0BCF6C1B7D46D" modified="2011-06-28" version="1">MADIVALERALSAGRLEPYVKAAGGGLAEGIQLYEWNTAVSAAFFEVLGHFEVVLRNALHEQLRVLGGREDWWLAPRFDFTPPANDMIAKACAEMGRRGASGSPGHVVAALPFGFWVALLSAGGDCNYEMSLWRPGLRQAFPGYSGTRARLHPRLNTLRLLRNRIAHHEPIYRRHLAADHDTVLEVVGWIVPGFANWMRQRSRVPNFLAQRPFSAEPPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGT8</accession>
    <name>F4FGT8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrrolo-quinoline quinone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_02570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736231.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02570"/>
    <dbReference type="EnsemblBacteria" id="AEB47598">
        <property type="protein sequence ID" value="AEB47598"/>
        <property type="gene ID" value="VAB18032_02570"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02570"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718929_0_0_11"/>
    <dbReference type="OMA" id="TPYWSYR"/>
    <dbReference type="OrthoDB" id="1089567at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="414" mass="43349" checksum="0C3B9B22C46E2EF6" modified="2011-06-28" version="1">MGWTTGQRRIVAAVAATGVAAALALVAYRVLAPAEVSTAARGDHPARSQPAPGVVGRLPAAPLIVDGRLRVYAAQRQVYADQPADGRHRSTPYWSYRRWPATVDAVVASGTTVVSRWSDGKLVALDARTGQVIWRADGPEPDRERVTRRTGSAIVWQPRGVSVVRTADGRDTVVTSGSGEVRAVDLAGGAQLWQAEVGRGCREPVGGSADGQLLTLDRCAGPTVVEFRDVATGKVGDRWRPPAAGDELTATLIGCAPTGCAALRTAGPDDMSARGWLLGSGEPVAAPVLDAADAELLDGTAVTLTDGLLVGRAVRNGTERWRASVGPGRLIAVQSDRVHVLTAGNELVTLDAASGRELSRFILNVGSDGTGWLPGAVHAADGYVAVERLRRPVDLDGDDHTYYFTAEPVIIAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGZ4</accession>
    <name>F4FGZ4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42608">
        <property type="protein sequence ID" value="AEB42608"/>
        <property type="gene ID" value="VAB18032_07430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07430"/>
    <dbReference type="HOGENOM" id="CLU_1155992_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="240" mass="26484" checksum="25901FAB228DF1C2" modified="2011-06-28" version="1">MPEESSRASYWKTWTFETDTLDELIDVSPKGRIFHFEIEATSSEGNVHLKVGGPHKKDRRLMLHGEASGSDVPGVFHKIATMLEPAEKRGTKLHYLGAFIGPTMALYIPMLIFTLLWPGLGFFTDPPADAKDKPALAVVASALALLILLPLGMGIFSRITASSVTLRPRFDPSALKPEIDFASMPRRFLETVAAGLRWVASLYKHDELAQQKMLIATVTAAFFGIGSFIIATLAWLFPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHF3</accession>
    <name>F4FHF3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_20115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733780.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20115"/>
    <dbReference type="EnsemblBacteria" id="AEB45125">
        <property type="protein sequence ID" value="AEB45125"/>
        <property type="gene ID" value="VAB18032_20115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20115"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_18_11"/>
    <dbReference type="OMA" id="RRFVADM"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="182"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="249"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB45125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="479" mass="51197" checksum="AD57430C75F68608" modified="2011-06-28" version="1">MATDPVRPGRLRRRLTVAFVLVAGVSAGVLAGGSYLLLRQASYDASLHAAAADARYRLVLAGQFLPLTEQRRTELLTSFEGSGRHVVLVTGDVWPSHPQHAPALGEPLRATVAAGQLGYQRSDGPPRLLVVGGRIPGSTAELYVITGEDDVAAGLDRLRNALAAGWVLVTVLAAAIGHTLAQRTLEPVGRASRAARAITEGLLATRLPVRGRDEFSDWAASFNEMAEALQAKIVALRRAQDLQRRFTADVAHELRTPVTALVAAASLLREHLDQLPGDARRAGELLVEDVVRLRRLVEDLMEISRLDAGQEAVVVADVDAPALLRAIVATRGWQGRVEVDDEPVRLRTDPRRLERVLGNLIANAVQHGDGEIRARVARAGNRVVFDVDDQGPGIPAAHLPRLFDRFHKVDPARSGGGSGLGLAIAQENAQLLGGRLTVHSAVGSGTRFRLDLPDRLDLPDRLDADRCDAGSSDCTGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHH8</accession>
    <name>F4FHH8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridoxal-dependent decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733805.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20250"/>
    <dbReference type="EnsemblBacteria" id="AEB45150">
        <property type="protein sequence ID" value="AEB45150"/>
        <property type="gene ID" value="VAB18032_20250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20250"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_0_4_11"/>
    <dbReference type="OMA" id="RHATYHA"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="505" mass="54333" checksum="442C7D2641EC2CBD" modified="2011-06-28" version="1">MTLPVHTVTPPSAARAHLFHDGTVDDYRAAVTAGADRVARRVTEATGPFTGVRPEQLAPLVDAIDLDRPLRDTTAALDELDEVYLRDAVWFHHPRYLAHLNCPVVIPALLGEAVLSAVNSSMDTWDQSAGATLIERRLIDWTAARIGLGPAADGVFTSGGTQSNLHALLLAREEALAGASPTDRRILLPRLRIITSAAGHFSVQKAAKLLGLAPDAVVVVQTGPDRRMRAGAVRHEISRCRRAGLTVLAVVATAGTTDFGTIDPLDEIAEVCATSGAWLHVDAAYGCGLLVSPTRRHLLDGIERADSVTVDYHKSFFQPVSSSAVLVRDRRTLRHATWHADYLNPARMVAERIPNQVDKSLQTTRRFDALKLWLTLRVMGPDAIGELFDEVCDRAAQAWQLAAADPRFEVLTASALSTVVFRWRPAGTPADLADAANLHARSALAASGLAVVAGTKVDGRQYLKFTVLNPATSPDDVAYVLDLIAEHAGRYAPNTSTLELPCPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHJ5</accession>
    <name>F4FHJ5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_20335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733822.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20335"/>
    <dbReference type="EnsemblBacteria" id="AEB45167">
        <property type="protein sequence ID" value="AEB45167"/>
        <property type="gene ID" value="VAB18032_20335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20335"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_11"/>
    <dbReference type="OMA" id="RDVKLNQ"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB45167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="380" mass="40637" checksum="9B65357324484DB6" modified="2011-06-28" version="1">MTVERILPTDEAHDLLELTTELADRELAPRVVEHEQRGEFPREVLRTLGRAGLLGLPYPEEYGGAAQPYEVYLQVLEILAGRWLTVAEAVSVHTLSCYPVAAFGTDEQRSLLPDMIGGELLGAYCLSEPQGGSDAAALTTKAARDGDEYVVTGTKAWITHAHTADFYNIFCRTGGPGPKGISCLLADRATPGIAPQTAERTMGLRSSPVAQLVFDDARVPADRLIGGEGKGFTIAMAALDSGRLGIAACAVGLAQAALDYAVTYARERQQFGRAIIEFQGLGFTLADMATQISAARALTLAAARLRDAGRPYSIEAAKAKLFATDVAMRVTTDAVQVLGGAGYVADHPVERYFREAKVLQIVEGTNQIQRMVISRALAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHJ8</accession>
    <name>F4FHJ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733825.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20350"/>
    <dbReference type="EnsemblBacteria" id="AEB45170">
        <property type="protein sequence ID" value="AEB45170"/>
        <property type="gene ID" value="VAB18032_20350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20350"/>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465163_0_0_11"/>
    <dbReference type="OMA" id="FNASDAM"/>
    <dbReference type="OrthoDB" id="1159548at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="561" mass="60090" checksum="53D230FB3A3850E1" modified="2011-06-28" version="1">MNAKSGLRGWLAGRMPALAAEVAALAALLLAAVADSPWWALPPALVALGLLGYLWRNALSGGPTPSGSTLVIRLLLLACAYLLGVVHSGADLVLALGVGVAALAILAEPAVTATSRSVYPVSANLRGSGLRPNLRPNTSRAVLVNGAAVVVALVCAFAGTLEVISLVVSVAALALIAFTGWQAVTRVRARHASETRLNAALAAYEPVFLLHWEAPAGTAYQVGMWLPYLERLGKKFFVLVRSEANFNEVLRMTTAPVVLRSGLTQIDDVIVPSLRAAFYVNTATKNNHLVRYTNLTHIQLNHGDSDKVPSHNPVFRMYDKNFVAGQAAVDRFAANGVSMPAEMFSIVGRPQVENVAIAAAPIASLTAPRVLYAPTWAGFYADSNYSSLLVGYDIVKALVSRGCSIVFRPHPYTMRSAALTQESERIKALLAEDRRTSGRKHVFGAEAETKMSVVDCFNASDAMVSDVSSVVADYLYSEKPFAMVAVSTPAERFTDAFPLARAAYVIDAHSGRVTNLDPVLDDLLGSDPLAATRHDLKKYYLGDIPSEGYAQHFIDEANRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHL6</accession>
    <name>F4FHL6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735036.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26435"/>
    <dbReference type="EnsemblBacteria" id="AEB46385">
        <property type="protein sequence ID" value="AEB46385"/>
        <property type="gene ID" value="VAB18032_26435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26435"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008270_1_0_11"/>
    <dbReference type="OMA" id="DDATPHW"/>
    <dbReference type="OrthoDB" id="175945at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="323"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="870" mass="89768" checksum="B57D7AFE6F6B86A1" modified="2011-06-28" version="1">MGRLASAYGQAIGAHRAARAHLDAARHTLQQSTPTAPTVDPDLLALLARVGGTLATPTPGTPLAGQPVPVRLGEAVTAGGGFPVLVPLGAGHHLAVDTDARDPAVAGLLRAVVLRLLATAAPGGVRVAGCDSAALGATFGPLRPLLDAGVIDPPATTEPEVAALLDAAEQHARTARQAARPDQDLLVLVAASVPSPRDAARLAALTHAGPAAAVCVLLAGWRAAGPGEPAPPLGATTVLRMIDGYARVGDPPHAPFSADGSGLAVPVRLDGDPPPASVAALATHLGEAARRGATIGFADLLPSRRWAASARAGLRTVVGRAGREPFTIAFDDATPHWLVGGRTGAGKTVFLLDVLYGLAARYAPSELQLYLLDFKEGVSFTEFVPTGRDPSWLPHARAVGIESDREYGVAVLRELRRELQRRATALKRHGVTKLADLPAATAVPRIIAVIDEFQVLLAGNDPISRESVDLLEELARKGRSYGVHLVLASQSTTGIEALYGRAEAVFGQFALRVALPGGGGVLDPLNDAAATLPVGSAVINTAAGVTGANTVIRFPDAYAAVDELTRLRHELWQARPSDARPPSVFRGYETARVEDDATFTGLRPGGRRPLALVGRTVDVDGTSALFIMDTAPGRHLAVVGTSAAGAEVLRAATLSLARQHTPGEATFLLAPLVAAADPAADDTAATLTTAGHPVVRLDAAALRRHLATLAAAGGPGPTAEPTVASGSAGDAGAVGSDMLGAAPGRSYLVVFGMDAAAGLLAESDPATFRSGHDDLRTLLRQGPGHGVHLLGWWRGLRRLADDLGGTQNRDDVACLVALNVPGADLGLHLGVHDLAYMPRADRALLVDRHDQRIRLIVPFARDGYTAEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHM4</accession>
    <name>F4FHM4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpB</name>
        <name evidence="9" type="ordered locus">VAB18032_26581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735044.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26581"/>
    <dbReference type="EnsemblBacteria" id="AEB46393">
        <property type="protein sequence ID" value="AEB46393"/>
        <property type="gene ID" value="VAB18032_26581"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26581"/>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_11"/>
    <dbReference type="OMA" id="GPEHAMF"/>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="71"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="419" mass="43849" checksum="39DA80C4B1D90248" modified="2011-06-28" version="1">MSAGHGRSTAESAGPAAQFPDAAGHFGRFGGRFVPEALVAALEELDVAHRTAMADEAFRAEFGALLRDYAGTPSLLYEARRFSARAGARVLLKREDLNHTGAHKVRNVLGQALLTRRMGKKRVIAETGAGQHGVATATAAALFDLDCVVYMGQVDTERQALNVARMRMLGATVVPVTTGSRTLKDAMNEAMRDWVANVDDTHYLIGTAAGPHPFPALVRDFVRGIGDEARQQCLDLTGALPDAVTACVGGGSNALGIFHAFVDDPQVRLYGFEAGGEGVASGRHAASITGGSAGVLHGTRTYVLQDADGQTVESHSISAGLDYPGVGPEHAWLHDTGRASYLPITDDEAMAAFELLCRTEGIIPAIESSHALAGTLAIAGKLAAELGRQPTIVVNLSGRGDKDVHTAGGYFGILDGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHM9</accession>
    <name>F4FHM9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_26616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735049.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26616"/>
    <dbReference type="EnsemblBacteria" id="AEB46398">
        <property type="protein sequence ID" value="AEB46398"/>
        <property type="gene ID" value="VAB18032_26616"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26616"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="TQRFSYW"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="243" mass="25062" checksum="A292D88762DAB5E0" modified="2011-06-28" version="1">MVDAIAVRGLVVDRGGRRVLDGIDAVVPGGSVTGLLGPSGSGKTTLMRAIVGVQVITAGAVTVLGQPAGSAGLRHRVGYLTQAPSVYADLTVRENARYFATLHGRGADEADRAVADVGLAAAARQLVGNLSGGQRSRASLACVLVGDPELIVLDEPTVGQDPVLRADLWARFHELAAAGTTLLVSSHVMDEAARCDRLLLIRAGRLVADDTPDAVRSAAGVDDLDEAFLRLIRAAETTQAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHR5</accession>
    <name>F4FHR5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_26806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26806"/>
    <dbReference type="EnsemblBacteria" id="AEB46434">
        <property type="protein sequence ID" value="AEB46434"/>
        <property type="gene ID" value="VAB18032_26806"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26806"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_0_2_11"/>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="517" mass="53867" checksum="81DE85E7FEFFCD13" modified="2011-06-28" version="1">MAEADRTGDTVRAAGSATSGAGRTAGAGAPGPVTPGGPWRGLDALGGLAALQGLLARPLASYHLLLASAGLLLLIGLTMVFSATSVRDYAAGGNASASLVKQAIFAVIGIVAFWVCQRLPARTYRALGRPVLAIAVGLLLLLNALVAYGRLTGAPARIGPMEAELLGLYVGGIGVQPSEVAKFALVLWGAYVLARKGAALGWWRELATPLFPVVGLMFVLVGYNDLGSMLCLMALVIGLLWAAGVRLRVFATLSAIGLAGIGLLVAVASLGAGSGVRGEDNYRLQRLTMFVSPPPLEQCREELCYQMVQARYAIANGGWFGTGLGQGRSKWDWLPAAENDFIFAVIAEELGVVGCAVVVTLFAVLAYTGLRIARRVDDPFRRLAAAGVTAWLIGQAFINIGGVIGLLPLTGVPLPFISVGGSALVVTLAAVGMLASFARAEPDAARALHARPPARWVRLVWAPLPPLPGRRRRAASPSAARGSVPRARKRRADDQAAPRGARDGRGRSGSVASERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHV6</accession>
    <name>F4FHV6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736281.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02825"/>
    <dbReference type="EnsemblBacteria" id="AEB47649">
        <property type="protein sequence ID" value="AEB47649"/>
        <property type="gene ID" value="VAB18032_02825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02825"/>
    <dbReference type="eggNOG" id="ENOG5033JK8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472235_0_0_11"/>
    <dbReference type="OMA" id="LEFLFTR"/>
    <dbReference type="OrthoDB" id="1808686at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="185" mass="19488" checksum="9481636F00853619" modified="2011-06-28" version="1">MTAVRRVIEFLVTRLLRSRLGVALGIAVLVLGVVGAARLVAGPADPTTGLSNRPSEPITTVHPTAGDDGAISTTTTPTPVTSPGEAKPEQVAKRFVVAWLGGSGLTAEDWHEGLRPHSTATLMDKLAGADPAGVPAGEMTEEVTIRPRSETFVEALIALDSGRLRLELVAPQGRWLVDAVDWERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHX2</accession>
    <name>F4FHX2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein ftsk/spoiiie</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_02905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736297.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02905"/>
    <dbReference type="EnsemblBacteria" id="AEB47665">
        <property type="protein sequence ID" value="AEB47665"/>
        <property type="gene ID" value="VAB18032_02905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02905"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003134_1_0_11"/>
    <dbReference type="OMA" id="WEWMKWL"/>
    <dbReference type="OrthoDB" id="7548at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="460"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="815"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="483"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="834"/>
            <end position="841"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1316" mass="140744" checksum="2CF80C595238D39A" modified="2011-06-28" version="1">MSTVVIRRPPRRPAPQIPVGELPVEAPPEIPAVTGGRWHQMLMVLPMLGGTIAMAMMFGRGGGAYSYVVGAMFGLSSLAMLVTSWGSASGSPRKSEMMAARREYLRHLATLRRQVRQAAARQRTGLCYRHPDPGLLWSTVDSHRVWERRPTDPDFAVVRVAVGPQTLATPLIPPVTRPLEELEPMTAGALRRFLDAYSVVPDLPVALSLRSFARVFVRGTPAGNTGSPAAQALVRAMLTQLAVFHAPDELLVAVCAGPERRDRWEWTKWLPHAQHPTRSDALGPIRLVTSSAVELERLLDEVLVSRPRFSPAGPATDGPHLVVVLDGGDLTGATELAGDGGIDGVSLIDLDTPPPRLLDRFALLLELRDGRLHSHSADEAAEVGTADALSIVEAEAVARRLAPLRLAAATGGKDAVPGVEPGLPELLGLGDPAGFTAEQGWAPRSARERLRVPLGVGVDGGAVELDLKESAQDGMGPHGLLIGATGSGKSELLRTLVLGLAATHSSEQLNFVLVDFKGGATFASFDRLPHTAAVITNLADALPLVDRMVDAINGELVRRQELLRRAGNFASLRDYERARASGSPLAPLPSLLLICDEFSELLSAKPDFIDLFVQIGRLGRSLGVHLLLASQRLEEGRLRGLDTHLSYRIGLRTFSSLESRTVLGVPDAYELPRTPGHGYLRFGTEPLLRFKAAYVSGPVRRRGASASAAGPDRPRLLTFSTHFTPVAQPPVPAITAEPDEETGQTLLDLLIGRLAGQGPPAHQVWLPPLDGAPALDELVGPLTIDPVRGLTFGNPELHGALQVPVAVVDKPYEQRRDLLWLALDGAAGHVAVVGGTQSGKSTALRTLICALALTHTPAEVQVYCLDFGGGGLAAVRDLPHVGGVVGRADPTGVRRTVGEMATLLAEREHAFAESGVESVAAWRQRRATRLAGGSAESDRFGDVFLVVDGWATLRGEYDDLEPLITDLATRGLSYGLHVVATAVRWLDFRPAIRDLFGSRLELRLGDPSDSLVARRAAADVPEQTPGRGITAASLHFLVALPQSIGSDTAALVKQIDGAWSGPSAPPVRLLPAVLPYADLDRDAATGLRIPIGIAEADLRPVLLDFTTEPHFVVYGDAECGKSSFLRALASTIVSRFTPEQARVILVDYRRSLLGVIEEPHLIGYGTTAAHTSDLVESAAGYMQGRIPGPDVGPAQLRDRSWWTGPELFVLVDDYDLVASGPANPLRSLEEHLPHARDVGLHLVLVRRCGGAGRAQYEPIVQRLRELSTSGLVMSGSPDEGALVGPVRPGPLPAGRGRLFTRREGVRLVQLAYLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI23</accession>
    <name>F4FI23_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_30119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AB-18-032</strain>
            <plasmid evidence="1 2">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713109.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47987">
        <property type="protein sequence ID" value="AEB47987"/>
        <property type="gene ID" value="VAB18032_30119"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30119"/>
    <dbReference type="eggNOG" id="ENOG5033SSK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841844_0_0_11"/>
    <dbReference type="OrthoDB" id="1115150at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="35284" checksum="DA59941E9E1A24F4" modified="2011-06-28" version="1">MEIRTEQQLNPVADEVSAITAVVRPILVGILYSLKSDVVAEAGGRKGVKLKMLPRLRRPGDGDTGICFEYAAHDAVRRGEASVAERVYDALAFCKVPGEDVGSILFGAEKAGSQQLIDTAADLLTDDSSLLSGSRGRPVKLKKHLTAAAAAFRRKGIVSALPQSISGLWRADLFLGSPSTDYWVGTTVKINPATLQGDRGLRIGVIPASQGKSDKIRKDEKRNLILCPLPYDGSFVETFYLAWEVVTAFLAADAQVPKEVALPRPAARTVARYLADRREFPVLDVVEALDTLAQPELLQTETTAAGVILSGGTSSVVETTSVLAPAPTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F168</accession>
    <name>F4F168_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ordered locus">VAB18032_08020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731395.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08020"/>
    <dbReference type="MEROPS" id="S14.008"/>
    <dbReference type="EnsemblBacteria" id="AEB42722">
        <property type="protein sequence ID" value="AEB42722"/>
        <property type="gene ID" value="VAB18032_08020"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08020"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_11"/>
    <dbReference type="OMA" id="TIQAENM"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="21571" checksum="71035F2EDE9A7C53" modified="2011-06-28" version="1">MITMLDDGQRTFGDQVFERLLRERIVFLGSEVTDEAANRITAQILLLAAEDSTRDIRLYINSPGGSVSAGMAVYDTMRFVPNDVSTLALGLAGSMGQFLLCAGTAGKRYALPHTRILMHQPSGGMGGTASDITIQAENMLHVKRTMQELIARHSGRDLTEIQQDWDRDRWFTAEQARTYGLIDHVLTTTTQIPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1G3</accession>
    <name>F4F1G3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1992 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_20460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733846.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20460"/>
    <dbReference type="EnsemblBacteria" id="AEB45192">
        <property type="protein sequence ID" value="AEB45192"/>
        <property type="gene ID" value="VAB18032_20460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20460"/>
    <dbReference type="eggNOG" id="ENOG50318KY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109304_0_1_11"/>
    <dbReference type="OMA" id="MTERKPP"/>
    <dbReference type="OrthoDB" id="1950808at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DUF1992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1992" evidence="2">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="155" mass="17613" checksum="07ACED5DFA8AC487" modified="2011-06-28" version="1">MDSWQASVEAQIRSAQERGEFDNLPGAGKPIPGRGLPYDESWWIKSFMEREQVPTDLLLPTPLLLRRRIEQLPDEVRDLPTEQSVRACVAALNEEIIAWLRNPSGPKVVVRPVNADAVVRRWQADRRATRTASPAAVAEAPTPPRRTWFRRRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1T1</accession>
    <name>F4F1T1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group 1 glycosyl transferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735156.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27166"/>
    <dbReference type="EnsemblBacteria" id="AEB46506">
        <property type="protein sequence ID" value="AEB46506"/>
        <property type="gene ID" value="VAB18032_27166"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27166"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_11"/>
    <dbReference type="OMA" id="FDAEQPF"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="185"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="377" mass="40648" checksum="0824B40B51BBF401" modified="2011-06-28" version="1">MGRTLLVTNDFPPRPGGIQSFVHNLAVRQPAGSVVVYASSWPGADKFDADQPFEVVRERTRMLLPTPLVARRAARLARAYDCDKVWFGAAAPLGLLAAGLRRRADVRRVVALTHGHEVGWAALPLARTALRRIGRGTDVVTYLGEYTRSRLARALDGLTELRQLAPGVDTELYHPAVDGTEVRRRLGLADRPVVVCVSRLVPRKGQDMLIRAMPLIQRRVPDAALLVVGGGPYRATLTRLARQVGVEREVVFTGSLEWSDVPAHFAAGDVFAMPCRTRNAGLDVEGLGMVYLEASATGLPVVAGDSGGAPDAVRSGETGYVVNGRDVAEIAARVGLLLTDRDLARKLGAAGRSWVEQEWHWGAQAARLAKILAGDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1U7</accession>
    <name>F4F1U7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_27246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735172.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46522">
        <property type="protein sequence ID" value="AEB46522"/>
        <property type="gene ID" value="VAB18032_27246"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27246"/>
    <dbReference type="eggNOG" id="ENOG5031THW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203904_0_0_11"/>
    <dbReference type="OMA" id="CPELVCT"/>
    <dbReference type="OrthoDB" id="2084563at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="62" mass="6694" checksum="F975697F5C2C9013" modified="2011-06-28" version="1">MAERELHCDTCEGPQLFEVPPCLDGHGPTCPELACTRCGTALFLAPTPTPLRHPLPTPRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Z2</accession>
    <name>F4F1Z2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_03275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736371.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03275"/>
    <dbReference type="EnsemblBacteria" id="AEB47739">
        <property type="protein sequence ID" value="AEB47739"/>
        <property type="gene ID" value="VAB18032_03275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03275"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_11"/>
    <dbReference type="OMA" id="MIFMRDG"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="342" mass="35835" checksum="064588C89CE17C1E" modified="2011-06-28" version="1">MTGTTMTRPRRDGKNPTVGKGRGVPRLLTRVAVFAVIAAVPPLLFDDYWVFMAAQVLAFAVATLGLDILYGRTGQMSLAHASFMGVGAYTTYVMATHGYGPAMQLAAVIGVALVAALVVSVPTLRLSGMRLALVTLAFGELLAWAIRNTTDLTGGTQGASVDPFQFGRLDSSEPLHAYLIALVPAAIATAFAVHLGRTQLGRRMLAVRDSELAAESVGVAVARTKITAFLISAVYAGVAGWLYAGITGFIAPPDFDLFASVYLFVAVVIGGAGTVLGAWLGASYVVLMPEVFTLAGQPNLYPIVGGALLAIVALVVPDGIVGLGRNVWRRIRGVRGDEEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F219</accession>
    <name>F4F219_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coagulation factor 5/8 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_03410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03410"/>
    <dbReference type="EnsemblBacteria" id="AEB47766">
        <property type="protein sequence ID" value="AEB47766"/>
        <property type="gene ID" value="VAB18032_03410"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03410"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003192_1_0_11"/>
    <dbReference type="OMA" id="AYGYFFP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021798">
        <property type="entry name" value="AftD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11847">
        <property type="entry name" value="DUF3367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1290"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1387"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1421"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="707"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1479" mass="156107" checksum="C2B5B9349CAA06C5" modified="2011-06-28" version="1">MPPMSRLLASPLSRLSARVRRSPGTVLSLLLLTAIAFAQRPGQVTFDTKLDLAANPIHFMARALHLWNPEATSGELQNQAYGYLFPMGPFFAAGQLLGIPQWITQRFWTALLLAAAFYGLLRLARAMNIGTEPTRYAAALGYALAPRILTEVGALSSETLSAAMLPWVLLPLVTVRRIGSPRRAAALSALAVLGMGGINAAVVLMALVLPGVWLLTRRWDAEHRRLVAWWCVCVVGVCLWWIVPLLLLGQYSLPFLDYIESSTTTTAVASLFQAVRGTNQWVAYIVQGEPWWPAGWLLIDHPVLMALTAVVALIGLAGLAGNLLPQRRFLVAGFLAGLTLLTIGYVGAVDSPLSEVVRELLDGPLAPLRNVHKLDPVLRLPLMLGFAHGVDAVATRMHHALARRRPGVRLRPLVFVPVLMLVLGAAAPAWLGLLRPGPGWADLPPHWRSAATWLADRDALARTLMVPGSGFGQYEWGRTVDEPLQALAGAPWAVRHQIPLGSAGNTRMMDTVEEVLATGRGSTGLADLLARSGFRHLLLRNDIDRIQVDAPPVAVLRRALAESPGITRVATFGSTDALTRTIGSPVDEGFDTLPAIEVYQVDAPVPAASAVLTADVPTVSGGPESLLALLEQGVVERDRPVVLAGDRDGTPEATGESWIVTDGLRRRERDIGRVRDNLSQTLTANESGRQGRVALDLLPFPGEQHQTTATYQGVREVSASSAVSFVDTLGPADPSRLPFAAVDGDPHTAWHSAPLSGPVGQWLEVDLDTPRQVENVRLSFVTDLAVGWPVTRFRLTTDRGSVDHEVAPTLGGHTYYTLPGPTSRVRVTVLAVADGRLDGAVGIRELTIADTEPRRALRAPTDLPQDPAGPVSWVFSRGPADRPACHLAQASEADRIVPVGSPVRAADTVIRCDRFLARVGEEPLGLDRIFRNPAADTYRMALRAVARPGGDLKLSGLKVTASASSRLAGDPAVTAYAAIDGDPGTAWLADTGDLRPTLRLSWSGPRRIDQLRLRAAQLPVGSLPDEVEIRTPGREVVVPVGADGTVRFPAVRTNRIEIVVRSTELRIADQRGNGWPATAGIAEVEIPALAKLLEPVDAETRVVERCGDGPTVELDGHRYDTSVDARLGDVLAGRPVPLRVCGPGGAVLDLPAGGHRLGTSPSKGFLVQDASLRPVADATSGAADGATAPGVDGATSPAVDGAAARAVDAVDKPRHRAVTVLDWAPTDRTVRVDGGESALLVVPENANPGWTATLGGTPLTPTRVDGWQQAWVLPAGVGGEVRLIFAPDRAYRGALLAGALTVVGVLLLATWPARRRLDTVRVASVDAGRGASLGTGRGASVDGGGAAAIPAEVPAWLIGGLLVVLLAALGGVLPVAIVLAAMVLRQLAVRALPVVVLGGLTVATVIAVTGRVQGHGQSWAYGSWVQAAMLVAVGAVVAAVMPTPGVRTEPPVAHDVTPGTSGQPPRAAEGGTEDGTVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F255</accession>
    <name>F4F255_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08130"/>
    <dbReference type="EnsemblBacteria" id="AEB42744">
        <property type="protein sequence ID" value="AEB42744"/>
        <property type="gene ID" value="VAB18032_08130"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08130"/>
    <dbReference type="eggNOG" id="ENOG50331GF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128226_0_0_11"/>
    <dbReference type="OMA" id="ALWHVWH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="169" mass="17928" checksum="A73ACA7328FBC15E" modified="2011-06-28" version="1">MVTDEHNSTPLVDEAMKKASVAWVTVADGPALALWCVPLEGALCVVSGPGEQAAPGLAEADEAQVTLRGDHGGRIVTWRARVSRVLPGTDEWDTLAPLVGAKRLNAPGSTADLVARWAADDCALVRLRPAGDVVHGGQLPADSLAEPPRPTSAVRAARKPFRLHRVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F285</accession>
    <name>F4F285_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_08280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731445.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08280"/>
    <dbReference type="EnsemblBacteria" id="AEB42774">
        <property type="protein sequence ID" value="AEB42774"/>
        <property type="gene ID" value="VAB18032_08280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08280"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_0_11"/>
    <dbReference type="OMA" id="GKPLMHG"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="205"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="437" mass="44746" checksum="61E83C805DAC37EC" modified="2011-06-28" version="1">MTATADAEAAENGLTPLADYLGSVLRRLRALPPLDLDLTQAHGNVLAEDVVAPHSFPAFDQAAVDGYAARWEDIAGGGRGAIYVPAQSGGAAGRTVRLNVVGDLGAASWRPVRLTPGSCFSVAAGAPLPIAADVVVPVEWTDQGMAAVEIFRVPKRGYGVRRTGEEVAAGAVLARSGTYVSPALVAVLAATGIGHVVVRPSPRVVIVATGDELVDVGRGSQPGQVVDANSHALTAAAAEAGALAYRVGICDDDPEGLRGLLEDQTLRADLIITTGGTGTGPGDMVRRILSRREGNRAGPVTFTDVALYPGTALGFGTVGAEEVPVVCLPGDPGAAMIGFEVLARPAINLLAGAEPVFRPSVRAHLLETVSSPAGLREFRPAHVAERRGGGYTVQPLNGGPFTLSGLAEANGLLVLGERVTAAAAGSTVDVLLLDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2E6</accession>
    <name>F4F2E6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_14530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732685.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14530"/>
    <dbReference type="EnsemblBacteria" id="AEB44018">
        <property type="protein sequence ID" value="AEB44018"/>
        <property type="gene ID" value="VAB18032_14530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14530"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_11"/>
    <dbReference type="OMA" id="VCPYSWD"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="386" mass="41024" checksum="C2E3FA5802A63B9E" modified="2011-06-28" version="1">MRIGIVCPYSFDVPGGVQNHVMDLAEALIGLGHEVSVLAPADEDSPLPSYVVSAGRSVPLPYNGSVARIAFGPVSTARVRRWITRGDFDVLHVHEPLTLSVSMLAVLSARGPVVATFHTAMTRSRVLSAAQGALQIVLERITARIAVSALARKVQVEHLDGGAVEIPNGVAVAKFAGMQPLPGWPGECGPGTGGTLGFLGRFTEPRKGFPILRDAFVELAARRPGLRLLVAGPGDPDDLFDRFPPELRDRVTFLGLVPEADKARMLRSVHLYVAPNTGGESFGMILTEALAAGTTVVASDLDAFRRVLDNGRAGRLFRTGDAAALAQTLTDLLDDPAARAELTACGDQVVANFDWPVVARRVLEVYAAAIEATDGRVIDQEWVGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2H0</accession>
    <name>F4F2H0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14650"/>
    <dbReference type="EnsemblBacteria" id="AEB44042">
        <property type="protein sequence ID" value="AEB44042"/>
        <property type="gene ID" value="VAB18032_14650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14650"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_3_11"/>
    <dbReference type="OMA" id="FRTALMQ"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="204" mass="21817" checksum="22072E24F6481394" modified="2011-06-28" version="1">MQVDELTTLGRRDRKKRQTRAALAAAALRLVAERGLDQVTVEDISEAADVSARTFFNYFPTKDDALVGDSEGDRERVLRALAAVPAEQPALEALRRAFIAAVEEAQGDAELWQLRLRVVTQHPVLLGRLVTGNATTERALVEAIAARTGLPADDAYPALVVAVAGAALRAAMIRWATGDAHRLAALLDESFATVAAGLPDPRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2N5</accession>
    <name>F4F2N5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733954.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21000"/>
    <dbReference type="EnsemblBacteria" id="AEB45300">
        <property type="protein sequence ID" value="AEB45300"/>
        <property type="gene ID" value="VAB18032_21000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21000"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091682_0_0_11"/>
    <dbReference type="OMA" id="PDCANLG"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="21429" checksum="94C997FE03B4EE21" modified="2011-06-28" version="1">MRTTKYTHSCVRLELDGAVLVIDPGTWSEPRALAGADAVLVSHEHTDHVDVLRLAGLGVPVFVPEGAVLPDLARLPVTRVRPGQRFTAAGFEVTAVGGRHATIHGDQPDCVNLGYLVDDAVYHPGDSLHLPGRPVRTLLVPAQASWLKLTEAIDFATAVGATEVFPIHDAQLNDRGLASVNGWFTETVPGYRYLAPGETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Q2</accession>
    <name>F4F2Q2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_21085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733971.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21085"/>
    <dbReference type="EnsemblBacteria" id="AEB45317">
        <property type="protein sequence ID" value="AEB45317"/>
        <property type="gene ID" value="VAB18032_21085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21085"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023778_0_0_11"/>
    <dbReference type="OMA" id="TATFFEC"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="560" mass="57283" checksum="D9B2046DC4B05BFF" modified="2011-06-28" version="1">MIGWQVSGYTSVRRLGAGASGSVDLAVHDATGTPVAIKYLTGRLHDDLFRAAFRTEAQLLSDIDDPYVCRLYEYVEAPDGAAIVMELVNGVSLRQMLRAQGPTTPESALCVLKGSLAGLAAAHARGVVHRDYKPENVLISAEGASKLADFGIAMPVGADSGGSVTGTPRYMAPEQWTGAPASPACDIYAATATFFECLTGHPPYDGRDLATLRQQHVRGSIPTDPAPRPMHGLLRHGMAKRPADRPQPAQVFLAELERAAVGAYGADWEERGLRELGRRAALLAALFPFPDGSGGTVSVASTALGASGAPPGGDGTGERPAPRRTGRARAALVGGGLVTALLVGGVGLGYAAQDEPPVPTGAAAEARTDLTVDPAATVGAVLTPAPTLTSTPDVSGTPTLTPAAPTTGGTTAAAGPSTSPTPSDSPAPSTVAPTPSTSTSPAPPSDAAPTIGRVSVSPTELDPVGCPFGPTTSTVTAIVDDDHSASVDLRVHFRYTIGQQSHERSLSLLKSGQFRGVLGDLPQPRSTTRIPVTVVATDAAGNTATSQTVYVTLYPFCTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2S0</accession>
    <name>F4F2S0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_21175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21175"/>
    <dbReference type="EnsemblBacteria" id="AEB45335">
        <property type="protein sequence ID" value="AEB45335"/>
        <property type="gene ID" value="VAB18032_21175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21175"/>
    <dbReference type="eggNOG" id="COG3265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077168_4_1_11"/>
    <dbReference type="OMA" id="ENFIQVS"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="23087" checksum="C26F9861E9ED85E3" modified="2011-06-28" version="1">MTGEPSTRHIVVMGVSGAGKTTVARGIAARTGLAFAEADEFHSEANVARMRAGIPLDDDDRWPWLQALADWMTARHREGVSTVLTCSALKRSYRDLLRQGPPGVFFVHLDGPTEVIRERMSVRTHEYMPPSLLNSQTATLEPLWPDEPGIVIDLRSTSEALVDEAVRRLGLPARDESPEALAGIEVPVDTELVAATEAVAVVEERPDLSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2X7</accession>
    <name>F4F2X7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Roadblock/lc7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27576"/>
    <dbReference type="EnsemblBacteria" id="AEB46588">
        <property type="protein sequence ID" value="AEB46588"/>
        <property type="gene ID" value="VAB18032_27576"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27576"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118613_0_1_11"/>
    <dbReference type="OMA" id="INVGRLH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="2">
        <location>
            <begin position="40"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="160" mass="16559" checksum="72600B03E5FA8849" modified="2011-06-28" version="1">MSDRDTMLPRRTAAPPAGPPPTKLPPSLAGNPSLPYPAIGTELTELRLQIPGVRGSVLGGVDGLRIAHDLPAPLNPDDLAAMAATAFGLGRQASHRLGQGDFRQSTVRNDGGYFAVYAVGAHALLSVVGTDTINVARLHLHAPPVADRLATLLAPAVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Z7</accession>
    <name>F4F2Z7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735258.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27676"/>
    <dbReference type="EnsemblBacteria" id="AEB46608">
        <property type="protein sequence ID" value="AEB46608"/>
        <property type="gene ID" value="VAB18032_27676"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27676"/>
    <dbReference type="eggNOG" id="COG3226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_21_0_11"/>
    <dbReference type="OMA" id="MARNPER"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="20830" checksum="841EF58DB6D75976" modified="2011-06-28" version="1">MARNPQRRAALADAGLRVLAAHGARGLTHRAVDAEAGVPVGTTSNYFRSRDALLGALGERIFERFAPDDAVVAELAARPPSSALLTDYVRYIVERTTRYPELTRALIELRLESARRPDLARILGDTLRRGYRADVAYHLAAGLPGGAFEVALLRYAVDGLLLDLLTTSIDTGFDPDQVIAALVSRLAGDVPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F330</accession>
    <name>F4F330_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736441.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03635"/>
    <dbReference type="EnsemblBacteria" id="AEB47809">
        <property type="protein sequence ID" value="AEB47809"/>
        <property type="gene ID" value="VAB18032_03635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03635"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494262_0_0_11"/>
    <dbReference type="OMA" id="VTSHVDY"/>
    <dbReference type="OrthoDB" id="683757at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="551" mass="62264" checksum="8CAFDD33EC73B3DB" modified="2011-06-28" version="1">MWLRADKKAFDGFLDAASVYWRKNLGSTSSQRYLVVEVFHQDIRVALRNLAVANAIRRIVPAQLVVVTGVEQMWHDALWTEFDVQLVRRLAEAYGASEVIDLYRLVDGPARSATPSQVRLELFGRPLRPGPAISEQTLAEFVSATYCRVTKRPRPPEDPTADPRYQRRQALARAISSAYDALLGDESVVALVTSHVDYDHWGLAVDSARRAGVPVVHTQQTGCLKAYALFPETDTGKHTFRGELTQQIGAFFAERVWSRREEVRRNAELVAWRSKVNLGRPSWWRGGASASVDINNSAERARLRTHFAARLGFDPARPMVAVFNHAVSDAPGTNHQSFPTLADWFEETARFASTATQVQWLFQDHPSQFRYDSTGFFESVAARYARHRHMVFQPSKDLSKNGLWSLVDLGVTVRGSVSNELPAYGIPVIQAGWSEWSECGLSTVVHDPETYWKALDSAIGALGSGEELISAEQVERARLWLWFYRSGTDLFTPQVPQWEVWPADHLLKSVQVAFRHIESDADPLFEAVERMWNRREPVLTRTDLHRPGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F333</accession>
    <name>F4F333_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_03650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03650"/>
    <dbReference type="EnsemblBacteria" id="AEB47812">
        <property type="protein sequence ID" value="AEB47812"/>
        <property type="gene ID" value="VAB18032_03650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03650"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_1_11"/>
    <dbReference type="OMA" id="FASKHTF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017535">
        <property type="entry name" value="Asparagine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03104">
        <property type="entry name" value="trio_amidotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="343"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="568" mass="62261" checksum="918E0D8DA9F1F50D" modified="2011-06-28" version="1">MRSRGPDGTGRWSADWVTLGHRRLTIIDLSEAGSQPMVREDLGLALVFNGCIYNYPQLREELRTAGHAFHSTSDTEVILVAYAQWGENFVDHLVGMFAVGLVDRARRRLVLARDRLGIKPLYLAETAGRLRFASTLPALLAAGEVDTDVDPVALHHYLSWHSIVPAPRTILRGVRKLPPATVRVVEADGHSRERVYWRPDYVRQATHRDWDARDWQDAIGDALRTAVARRLVADVPVGVLLSGGLDSSLIVALLAEAGQEHLRTFSIGFDSRGGEAGDEFHYSDLVARAFDTDHQRIQLANDDLVPAVRRTIGAMTEPMGSHDVVAFHLLSEQVARHVKVAQSGQGADEVFAGYGYHQPFTEVPRHQAAGAFAEAFFDHEHAELAGVVGPAYALVDDASGDLVDADLAAPGADTALDAVLRLDTHRMLPDDPVKRVDSMSMAWGLEVRTPFLDQDLVMLAAACPPEHKVAQGGKGVLKEVARQVLPAEVIDRPKGYFPVPALRNVDGPVRELVVEALRAPAARQRALFRPEYVERLLADPQAAQAAAGSNKLWQLGLLELWLQTHGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3G2</accession>
    <name>F4F3G2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_08840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731557.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08840"/>
    <dbReference type="EnsemblBacteria" id="AEB42886">
        <property type="protein sequence ID" value="AEB42886"/>
        <property type="gene ID" value="VAB18032_08840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08840"/>
    <dbReference type="eggNOG" id="COG4770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_1_11"/>
    <dbReference type="OMA" id="ITHFHTP"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="119"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="505"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB42886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="583" mass="61030" checksum="5B3140BFEE3D87E9" modified="2011-06-28" version="1">MRKVLIANRGEIAVRVIRACQDSGLGSVAVYADSDRDALHVTLADEAYALGGDTAAESYLRIDKLIDSAARSGADAVHPGYGFLSENADFAQAVIDAGLTWIGPTPQAIRDLGDKVTARHIAQRAGAPLVPGTADPVGSADEVMAFAVDHGLPVAIKAAFGGGGRGLKVARTMEEIPQLFESATREAVAAFGRGECFVERYLDRPRHVEAQVLADQHGNVIVVGTRDCSLQRRHQKLVEEAPAPFLTAEQRAQIHDSAKAICREAGYHGAGTVEYLVGNDGTISFLEVNTRLQVEHPVTEETAGIDLVREQFRIADGEKLRFTEDPTPRGHSIEFRINGEDPGRSFLPAPGTVTALRLPTGPGVRVDTGISAGDVIGGNFDSLLAKLIVTGETRTEALERARRALAEMVIEGMATALPFHRLVVRDPAFTAEPFAVHTRWIETEFDNTVPPFTGAADASAGPAERETVVVEVGGKRLEVSLPAGLTAGSASAAPAARKPARRGGGATVGATAGGDALTSPMQGTIVKIAVADGDTVAEGDLVVVLEAMKMEQPLHAHKAGTVSGLSAEVGAVITAGAAICTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3N1</accession>
    <name>F4F3N1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter, periplasmic amino acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_15135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732804.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15135"/>
    <dbReference type="EnsemblBacteria" id="AEB44139">
        <property type="protein sequence ID" value="AEB44139"/>
        <property type="gene ID" value="VAB18032_15135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15135"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_3_11"/>
    <dbReference type="OMA" id="PAYAPWF"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307646" evidence="3">
        <location>
            <begin position="25"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="53"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="5">
        <location>
            <begin position="53"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB44139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="288" mass="30680" checksum="90739D57B3DE3969" modified="2011-06-28" version="1">MVSTPRIRTLATAGAVLFAVTACAPQNEPAPPPSTSDAASCAKENLPTQTPGKLTIATDQPAYQPWFVDDKPENGQGYESAVAYAVAEKLGYTRDEVVWTRVKFDSAIAPGPKSFDFDINQFSITEERKKAVDFTAPYYLVRQTVIALKSSKIAGKTSLADLREAKLGAQVGTTSYQAITDVVKPTTKPQVYNSNDDAKKALQNGQLDGLVVDLPTAFYITAAEIDDAVIVGQLPQVGTPEAFGLLLDKDSPLTGCVSNAVGQLTADGVLKQLEQQWLAQVAGAPELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3R9</accession>
    <name>F4F3R9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734023.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21350"/>
    <dbReference type="EnsemblBacteria" id="AEB45370">
        <property type="protein sequence ID" value="AEB45370"/>
        <property type="gene ID" value="VAB18032_21350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21350"/>
    <dbReference type="eggNOG" id="ENOG5032SHQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146087_0_0_11"/>
    <dbReference type="OMA" id="FWALMIL"/>
    <dbReference type="OrthoDB" id="1496523at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025461">
        <property type="entry name" value="ABA4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14108">
        <property type="entry name" value="DUF4281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="145" mass="15565" checksum="0AA148425679DB7C" modified="2011-06-28" version="1">MTEVLFTLTFAVAAPFWALMILAPKWSVTARVIASPWIVLPGLVIYAVLVLPALGEVLPAVASPSLDGVRELLGEADGAAAGWAHMIVFDLFVGRWAWLDSRERRVPSLVMAPVLLLTILLGPLGLAAYLIIRGRWTPRPAGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3U5</accession>
    <name>F4F3U5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AEB45396">
        <property type="protein sequence ID" value="AEB45396"/>
        <property type="gene ID" value="VAB18032_21480"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049449_0_0_11"/>
    <dbReference type="OMA" id="NDVMHFD"/>
    <dbReference type="OrthoDB" id="796300at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="34042" checksum="DA434BDE68864913" modified="2011-06-28" version="1">MATAQVEADLANHGLTTSPDFRAVNLDRVIQVVLLQDHEASESDADDTAETSSPNIGELGEESVDIGLTLDNLFPHRMSLVSVAPTATFEEAITAMELNDYSQVAVLANSHTLYGSVSWESIAAAKHRDPGASFGDAIDRRARDRVFDYDTRLLDVLSTLQQHGFIFVRDDQRKISGIVTAADVVRKYDETATPFFLIGEIDQELRHLIVNTFDEETVRQACGGAHLSFKSLETMTMAQYQAVLNNANCWEQLGWPLSRGLFIERLDEIRRIRNNVMHFNPDPVRASEMAKLRNFLRLIQAYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3Z9</accession>
    <name>F4F3Z9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735295.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46645">
        <property type="protein sequence ID" value="AEB46645"/>
        <property type="gene ID" value="VAB18032_27861"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27861"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082070_0_0_11"/>
    <dbReference type="OMA" id="LEWDAFV"/>
    <dbReference type="OrthoDB" id="1585236at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="85"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="158"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="229" mass="25239" checksum="24FAB6D136F70D68" modified="2011-06-28" version="1">MASISTINRIDQDIRSAVLDELDWEPRVQPHEIGVTVAEGVVTLTGRVDSYAKKWAAERAAHRVAQVRVVANDIAVRLITGAERTDPEIATAVEHALQWRAFVPVEQLDVTVADGWVTLHGQVEWEYQRRAAEESVNQLNGVRGISNGITVRPTVRPDGSRLADRIVDALARNRATDAEQVTVRVHGDTVLLGGLVHSMPERAEVERVVWSAPGIREVQNHIAVAPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F418</accession>
    <name>F4F418_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abc transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735314.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27956"/>
    <dbReference type="EnsemblBacteria" id="AEB46664">
        <property type="protein sequence ID" value="AEB46664"/>
        <property type="gene ID" value="VAB18032_27956"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27956"/>
    <dbReference type="eggNOG" id="ENOG5032S7F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104659_0_0_11"/>
    <dbReference type="OMA" id="MTQTFPF"/>
    <dbReference type="OrthoDB" id="1666330at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="25335" checksum="F00BD9D4FDE9EFA0" modified="2011-06-28" version="1">MNRTLTVARMQFVAWRSVVGWPWAILLLSFAINLALFSAMNEKDDFEPTTGGLMSIYVVMFVASISAITMDFPFAIGLGVSRRSFYLGNVLHFVGQAIVYAAVLYLLAVIEQATDGWGVNLRFFGIPFLMVEHPVLRYLGFAIPFLLLGFVGIAIAVVFKRWGMNGMLTLSTVALVAVGGSAVLITWQGWWSAIGRWFADQPGAALLVGWPALLTVPLAVVSYLIIRRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4F427</accession>
    <name>F4F427_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_28001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46673">
        <property type="protein sequence ID" value="AEB46673"/>
        <property type="gene ID" value="VAB18032_28001"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28001"/>
    <dbReference type="HOGENOM" id="CLU_3278341_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="41" mass="3629" checksum="6CB0E8674ACECE59" modified="2011-06-28" version="1">MDGVVVAGDVLVGAGATAAATAGGAAAVVAPPSCTSGRKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4F451</accession>
    <name>F4F451_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">corA</name>
        <name evidence="8" type="ordered locus">VAB18032_03910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03910"/>
    <dbReference type="EnsemblBacteria" id="AEB47864">
        <property type="protein sequence ID" value="AEB47864"/>
        <property type="gene ID" value="VAB18032_03910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03910"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_2_11"/>
    <dbReference type="OMA" id="IQKYFRD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="397" mass="45471" checksum="A73624E39C06936A" modified="2011-06-28" version="1">MTDRIKRGRNTSTADQRTSPPDQDRARSAVAGRALRPRDWSPVRAMTRRLSPDGTRTVTVPAESPRSAVVDCAVYVDGRRQPGEWTFAEALAAARREESGFVWLGLHEPELAEMTEIAESYGLHELAVEDAVKAQQRPKLERFGEVSFLVLRTARYCEHTELTENSEVVETGQVMLFIGPHFLISVRHGDASRLAPVREELESRQDLLLHGPWAVAYAITDRVVDLYLEVADQLEDDMDVLEIEVFDRQATGRIQRIYQLKRELVEFKRAVMPLQRPLLALTTQMNREVPKEVRRYFRDVQDHLSRTVEQVNSYDDLLNSILQARLAQVTVDQNNDMRKIAAWAAIAAVWTAIAGIYGMNFEFMPELKVAYGYPVVLALMLTISLTLYRWFRRNDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F493</accession>
    <name>F4F493_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_04120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04120"/>
    <dbReference type="EnsemblBacteria" id="AEB47906">
        <property type="protein sequence ID" value="AEB47906"/>
        <property type="gene ID" value="VAB18032_04120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04120"/>
    <dbReference type="eggNOG" id="ENOG502ZPJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111456_0_0_11"/>
    <dbReference type="OMA" id="TDMVEQP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="198" mass="21176" checksum="0BD419B02704EA5C" modified="2011-06-28" version="1">MTEARTAGQNDEPGRDGTGHSGTVVVVGPDGRPVGTVQTDDGQGEDPTRLVEQPAKVMRIGSMIKQLLEEVKSAPLDDASRHRMREIHERSIVELKEGLAPELREELERLSLPFTEDQAPTEGELRIAHAQLVGWLEGLFHGIQAALVAQQMAARVQLEQMRSGRQALPSGPSGAALPGMPGLGQVPGGEGHSTGQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5G4</accession>
    <name>F4F5G4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ordered locus">VAB18032_09390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731667.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09390"/>
    <dbReference type="EnsemblBacteria" id="AEB42996">
        <property type="protein sequence ID" value="AEB42996"/>
        <property type="gene ID" value="VAB18032_09390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09390"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_2_11"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="OrthoDB" id="1701464at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="163" mass="16721" checksum="9523C012BDC89B99" modified="2011-06-28" version="1">MSTVGLIMGSDSDWPTMKAAAEVLAEFEVPYEVEVVSAHRTPVKMIDYGRAAAGRGLKVVIAGAGGAAHLPGMIASVTPLPVIGVPVPLKHLDGMDSLLSIVQMPAGVPVATVSIGNARNAGLLAVRILGASDPALLDRMSAYQADLEQLVAEKDAALRASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5G6</accession>
    <name>F4F5G6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731669.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09400"/>
    <dbReference type="EnsemblBacteria" id="AEB42998">
        <property type="protein sequence ID" value="AEB42998"/>
        <property type="gene ID" value="VAB18032_09400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09400"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043145_0_0_11"/>
    <dbReference type="OMA" id="DPGFTPS"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="333" mass="35039" checksum="DAFF5DCEF5C2BAAA" modified="2011-06-28" version="1">MLIGEVARRSGVSARMLRHYEALGLVRPTGRTGSGYREYANEDIRRIFHIESLRSLGLSLREVRRALDDPGFTPAALVDDLIRQTRDRIAAETDLLTRLRRVGAAEPADWSEVLQIVALLQGLRSDRAGERQRAALALPRAAVMPVEALVEAVLSEEDPNVAGALRWALAQSGDGGLALLAEGLDAPTAEVRRRAVEAIAEIPSDAATVLLRDALANADLAVGRYAALALGARGVADAVPTLVDMVVEEAGDVDAADALSVLAGEAALAEQIAVRLVGRLDAAGDAATRRRLVGALADIPGNTAAQALADLSADADPVVAHTAAHLLRLRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5H0</accession>
    <name>F4F5H0_MICM1</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731673.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43002">
        <property type="protein sequence ID" value="AEB43002"/>
        <property type="gene ID" value="VAB18032_09420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09420"/>
    <dbReference type="eggNOG" id="ENOG502ZFUI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1271099_0_0_11"/>
    <dbReference type="OMA" id="TVDRWVE"/>
    <dbReference type="OrthoDB" id="1775983at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="219" mass="23473" checksum="E40EA8AAE9E345DA" modified="2011-06-28" version="1">MRHLWSFLAGLVVAPVTWVLVTLGQDGSASTVNRWVEIGTSNTANLIEPAVYLAVGGIVLGLLGTLRISPLGPLVAGLLLVTPYIGMFVTPFGVRDRIPADWGFLGDPLPLRLPMENGTLFLIGMMLLVATFSGQRWRRWPQPVAAPMPASAAAPTPAAATEQTLTDWPPVESNEQDTAPLSLGYPDPTPTEPLPRRTGHTSPWSAPPGNLPRHDDTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5P3</accession>
    <name>F4F5P3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional activator domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_15720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732920.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15720"/>
    <dbReference type="EnsemblBacteria" id="AEB44256">
        <property type="protein sequence ID" value="AEB44256"/>
        <property type="gene ID" value="VAB18032_15720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15720"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013188_0_0_11"/>
    <dbReference type="OMA" id="WGTEAHL"/>
    <dbReference type="OrthoDB" id="1942781at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="191"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="901" mass="97254" checksum="7DE5B2F74D9D27A2" modified="2011-06-28" version="1">MPDESTQTRRLTEYGSRPTVYHPPQTPPPPPRGRAARSVRAAVGALVYLAGAPAVLWLVAGNPLRRLPTWPQLTAWLDQPQNRLTTEVLTGLAVWALWLFWAVFALLLLAELVAAVTRWRIPILRLPAPLHRLLFGLAGTAALAVTSTTHLPGPDTDPAPAAVTSTGNTPPVPQQAVARGPAIIHVADTRYVYTVERHDTLSKIATAWLGDTTRWPEICQLNKHRHFPTVGGTLRDCNLIYPGWELRLPADATPPADATPTPPRPHQPTHPTPTPPPPHDEDTDNGAEAPTTPTTTDPVPSPTRPTTPAPPTPSTAPTANSDPRPSPTPEQTAPSTESDGIELPGGSFLPWALAAAISAATALAWLHRRRRFTPARTDDPPALPPAVAEVHRRVVRNRDLPATADLAEQAAAVPDLPLLPAGGIGIVGDGAHAAARAALVTMLASGGPHKPHHRGEIVIDHATLTTLTGLDPATLTPWPRLHLADTPEDALTILDTMLLHRTRILDNHHLTDINDLRHQIPDEQTLPPVLLISPTPTPDTLRRLQATLHTAAHLDITALLLGTWPPGPTIAVTTDGHIQNPQDPETAPVGDRIAVLDTAHTVAFLTTLNEAHTGTPPTTTAPAEPATPAPLPTSRTHTDTADTPQPDQPAPDTTVKAHLRVLGPPRIDTITQPGRPLRAKALELAVYLAVHPDGATTRDIGEYLEPDARISQADQRVHTNASNLRHVLGRAGTADPKNAYVIKDAGRYRLDPTTVDVDVWRLRDLLRQATIATGPRRRELLTTACDLYTAPLAEGRDYEWVQPHRETISRWGTEAHLLLADDLLDHDPQAASDLLDKAISLDLYNEALYRKAMHARHALGDTNGIRTLLRALTKALTDIDTAPQHDTITLATQLRATLNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5T0</accession>
    <name>F4F5T0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732957.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15915"/>
    <dbReference type="EnsemblBacteria" id="AEB44293">
        <property type="protein sequence ID" value="AEB44293"/>
        <property type="gene ID" value="VAB18032_15915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15915"/>
    <dbReference type="eggNOG" id="ENOG50338MW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134413_1_0_11"/>
    <dbReference type="OMA" id="NITGWIM"/>
    <dbReference type="OrthoDB" id="2031158at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043993">
        <property type="entry name" value="T4SS_pilin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18895">
        <property type="entry name" value="T4SS_pilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="97" mass="9889" checksum="93F2D5B815445AE8" modified="2011-06-28" version="1">MHTTLSVLSDLAATAAQPLAVNSINQVIANITGWIMGIIALVATMFLVIGGLRYMAAGGDPAQIEQAKGNFKSALVGYALAVLAPVILQVLQGILGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5U0</accession>
    <name>F4F5U0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_15965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15965"/>
    <dbReference type="EnsemblBacteria" id="AEB44303">
        <property type="protein sequence ID" value="AEB44303"/>
        <property type="gene ID" value="VAB18032_15965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15965"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058045_0_0_11"/>
    <dbReference type="OMA" id="PYGRGTH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="4">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="26052" checksum="02D93227F4EF8895" modified="2011-06-28" version="1">MLPHLAAHAISSYTAPGDLVFDPMCGSGTTLIEAMHLGRHGLGIDIEPRFTALAAANIALARSQGATGSARVFTGDATTLLGVVPASTVGRVGLVLTSPPYGRGTHGLVQVTGSGVRKRNHLYGDRERGNLAYGGWSRLLDGFAAILAASYQLLRPGGTVVITCRPVRHHRDDLIDLPGELLTLARSVGLIPVQRCAAMLAAVRDGQIVHRASMFGLMAVRTSRAQGLPVHLIAHEDVLVLRRGPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Y3</accession>
    <name>F4F5Y3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">McnC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_22210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734195.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22210"/>
    <dbReference type="EnsemblBacteria" id="AEB45542">
        <property type="protein sequence ID" value="AEB45542"/>
        <property type="gene ID" value="VAB18032_22210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22210"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_4_11"/>
    <dbReference type="OMA" id="IVHWKEV"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="760"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="835" mass="88859" checksum="6FCC50CDDD8CBC36" modified="2011-06-28" version="1">MTEALTSAGPTSRPGTPAELSDDPRHVEYWRRHLRGAPPRLGLPYDRPPVSAPPASPASCELTLPPTVGRAVAVLARRERASTLMVVTAAMAAWASRLTGQDDILVTTPLARARHPEHVLPVTVRLDCSGEPTFTDVLRRTREVLLDALAHRNLDASTLSAIAGPPQLVVSVSDTPPAMVDGAQLQLWWADDGSRAALHYRSPWFTATTAQRLLHQLTLLLAGAAAQDSTRLSDLPMLSPADQELLDRLPRPGATPVTAVPAQLFAEVAATHPDATAVRTRNTSISYRDLDVRATKLAHHLRQAGAGPGSVVGVCVGRGIDLPLSFLAVLKSGAVYLPLDPRHPAERLRDILDAADATLVVSTASEAVAVAAHTGPLLLLDRDEAAIAAQPDTPVTDLPDPAELAYLIYTSGSTGRPKGVEVTQAGLANLAVTLREEFAVGPQDRVSLFSSAAFDASVWEMTMAFAGGATLGVLTTAEAAPAEIAAEIRELGLTVGTYPPTLLRALTPDDLGDPRLVVSAGEQCDTDLAAAWAPGRRFVNAYGPTETTVCATFTDVAAPVTDAPAIGTALPNLAVHLLDHRLRPVPVGAPGEIFVAGVGLARGYRRQPALTAAAFLPDPHGPAGSRMYRTGDLGRFGNDGRLYHLGRVDHQVKLRGFRVELGEIEHHLMAQPMVRDAAVVMRRDGDHDRLVAYLTVDEARTDPVALRGALRAALSRALPEYMLPAAYVVLDAMPLNSSGKIDRAALPESSGEAPAGPVEQWQTPDEQRIAGLWRDALGVAQVRRTDSFFELGGHSLVAAQMIGSVRQAYQLNRLPMRLLFEKPVLADFAAAVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F654</accession>
    <name>F4F654_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_28676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735455.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28676"/>
    <dbReference type="EnsemblBacteria" id="AEB46806">
        <property type="protein sequence ID" value="AEB46806"/>
        <property type="gene ID" value="VAB18032_28676"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28676"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094102_0_0_11"/>
    <dbReference type="OMA" id="GFAWLKQ"/>
    <dbReference type="OrthoDB" id="1711955at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="19368" checksum="63E37D6DC47FCAAE" modified="2011-06-28" version="1">MADQTQPWAERTVEVPPQPGGGIPPQRDPYRRGVASVGANAARTEPFTAVDQVPTGTGWPGEPAPRRPLSWHMAQLRKGGEWSAAGALFAFVCWGIWAISGGGDLAGPFLIFVLSLLVAAGLFALTRLLGRLVLERQLGRVRRSARGAHLVTALFLTGLGIAYLQQTQWVMDAWNWLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F699</accession>
    <name>F4F699_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28901"/>
    <dbReference type="EnsemblBacteria" id="AEB46851">
        <property type="protein sequence ID" value="AEB46851"/>
        <property type="gene ID" value="VAB18032_28901"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28901"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_6_0_11"/>
    <dbReference type="OMA" id="MTMRSAK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="138" mass="14996" checksum="65AC4023626496EE" modified="2011-06-28" version="1">MSHSVMSPGVEALLEQARAGMNRLTPQETVQAAARGALVIDTRTDMQRREQGDLPGVLVIDRTVLEWRLDPASDWRIPEATGYDIEVVVVCRQGYSSSLAAASLRALGLHRATDMIGGVDAWRAAGLPFSDRPADVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6H0</accession>
    <name>F4F6H0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43116">
        <property type="protein sequence ID" value="AEB43116"/>
        <property type="gene ID" value="VAB18032_09990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09990"/>
    <dbReference type="HOGENOM" id="CLU_1325900_0_0_11"/>
    <dbReference type="OrthoDB" id="551379at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="207" mass="23646" checksum="E32B6DF55DEA9375" modified="2011-06-28" version="1">MEAEAQLQHYLLHAFNLKFQSTGDLKALVDSEQVEQITDSLVGLKSDLRLAQNDALLACAVYGQRKARGESSNILEFGFETWWLTTETAMLRHTHDLERLNGGSRYMMRPDFLLNFLTFAPSVDQARRTFSNVFPSLLGIHLSRRLDEATFHKLMDDVQKAELMDEARRSAAMASLADRLKSDLSKRYAVELKEQVNRVPSQRKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6J8</accession>
    <name>F4F6J8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_16100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44326">
        <property type="protein sequence ID" value="AEB44326"/>
        <property type="gene ID" value="VAB18032_16100"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16100"/>
    <dbReference type="HOGENOM" id="CLU_949786_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="293" mass="31418" checksum="80D620B10F5C7E85" modified="2011-06-28" version="1">MPRVPFRPVTSPQIRLSDHVAAMRIGAQARPNARRWPVRPKRKRDAASTHGWGGRHQVINLPELIIEAPMPFEPQVSHPEAKRYVEGKGRIEGSDLKAFGIGMVNAVKPGQELPVDPYNQRAEWYGRGFAEAMAGQVAGGGVAWVAGKVAGKVIPAVRGAQRAAGAGAGQAVGKGTGAAADFVPDVYVGALKRWKVTPGQTYRGVTRRIRREVRDWSRKWGTMDGPATSGRVHAGHQPGGSHVFTPPGQTTRVGAQTARGNLSSAAAEARAAAFRRQWNANNPNGPQLPVRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7M8</accession>
    <name>F4F7M8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PrcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prcA</name>
        <name evidence="5" type="ordered locus">VAB18032_22825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734317.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22825"/>
    <dbReference type="MEROPS" id="T01.980"/>
    <dbReference type="EnsemblBacteria" id="AEB45665">
        <property type="protein sequence ID" value="AEB45665"/>
        <property type="gene ID" value="VAB18032_22825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22825"/>
    <dbReference type="eggNOG" id="COG0638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071031_0_0_11"/>
    <dbReference type="OMA" id="QIYRLPH"/>
    <dbReference type="OrthoDB" id="1243753at2"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_B">
        <property type="entry name" value="Proteasome_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="29184" checksum="5D8B4DC891DA42DB" modified="2011-06-28" version="1">MAMQFYASPEQIMRDRSELARKGIARGRSAVVLSYAGGVLFVAENLSSTLHKVSEIYDRIGFAAVGKYNEFENLRRAGVRMADLNGLSYDRRDVTGLALANAYAQTLGAIFTEQSKPFEVEICVAEVGATPEEDSLYRLTYDGSVNDEPGRMAMGGQSEAIAGVLKSHHQPDMSLGDAVKVAVQALSSVGGEGGAARTIAANQLEVAVLDRSRVGRTFRRITGAALTALLDGSAAGEAADEDRAKTPTTPTEEAHKPTTSAGSADLEDKPGNPSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7S3</accession>
    <name>F4F7S3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATPase AAA-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_23050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734362.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23050"/>
    <dbReference type="EnsemblBacteria" id="AEB45710">
        <property type="protein sequence ID" value="AEB45710"/>
        <property type="gene ID" value="VAB18032_23050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23050"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_11"/>
    <dbReference type="OMA" id="GPEHILM"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
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        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
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        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="35"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="11">
        <location>
            <begin position="446"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="442"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB45710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="851" mass="93883" checksum="2E48C2768E6FE072" modified="2011-06-28" version="1">MIGPGDFGSDPWDEFLARYFGRGEGGRRPAHRVDITRLMTADAREMLADAARRAAQKKSNDLDTDHLLWAALQREPLRDLVRRAGADPDTLINALGGRGDGAPQGEVPPNLSLTPAAKRALLDAHQLSRAMGANYIGPEHILMALPLNPESPAGRMLAAGRIQPESLQAANAERGPMTNPRPDRGTPTLDQYGQDLTELARNDQIDPVIGRAAEIEQAVEILSRRTKNNPVLIGEAGVGKTAIVEGLAERICDGDVPQTLLGKRVIQLDLAGLVAGTRYRGDFEERLKKVIDEIRAHREELIIFLDEIHTLVGAGGAGSEGGMDASNMLKPALARGELRVIGATTLDEYRRSIEKDAALARRFQPVFVPEPSVEDTVAILRGLRDRYEAHHQVRFTDEALVAAAELSDRYITDRYLPDKAIDLIDQAGARVRLRTRTPAADVRDLEQQLEEVRRDKEQAVADEQYERASALRDRVAELEEQVGRARGDEGTGSQVPEVGPDEIAEVVSRATGIPASQLTEEERDRLLRLEGHLHEKVIGQDDAVNAVAEAVRRSRTGLADPHRPMGSFLFLGPTGVGKTELARALAEALFGEADRMVRVDMSEFQERHTVSRLVGAPPGYVGYEEAGQLTEAVRRRPYAVVLLDEIEKAHPDVFNILLQVLDDGRLTDSQGRTVNFKNTVLIMTSNLGSELITGSQRAVGFGAGAPGSDQESDELRERLMRRLQENFRPEFLNRIDEVIIFRRLEAAQLRQITGLLLEETRRRLHAQDIEVDFTTAGVDWLAEHGYQPEFGARPLRRIIQREVDNQLSRMLLEQQLSPGQKVTVDAQDGQLSFDVSAGSRAHTAASTTHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7W2</accession>
    <name>F4F7W2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735585.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29331"/>
    <dbReference type="EnsemblBacteria" id="AEB46937">
        <property type="protein sequence ID" value="AEB46937"/>
        <property type="gene ID" value="VAB18032_29331"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29331"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="OMA" id="VEYAGRM"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="21739" checksum="D3082FA891907041" modified="2011-06-28" version="1">MDSVRYDAERQGSRIPIALKILIAGGFGAGKTTLVSALSEVRPLQTEEILTGAGVDTDDISGVEGKSTTTVAMDFGRITINDDLQLYLFGTPGQDRFWFLWDELAFGALGAVVLADTRRLADCFPSIDYFEQRGVPFVVGVNCFDGSQRFSLEAVRRALDLDPDVPMVLCDARDRQSGKAVLISLVEHVARQRGEPVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7Z8</accession>
    <name>F4F7Z8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_29511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735621.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29511"/>
    <dbReference type="EnsemblBacteria" id="AEB46973">
        <property type="protein sequence ID" value="AEB46973"/>
        <property type="gene ID" value="VAB18032_29511"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29511"/>
    <dbReference type="eggNOG" id="ENOG50331V9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151939_1_0_11"/>
    <dbReference type="OMA" id="ECQAPAI"/>
    <dbReference type="OrthoDB" id="1787593at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="99" mass="10794" checksum="1A2A96774F7C8CC2" modified="2011-06-28" version="1">MTAALEMPRVQECVVAACAYNHTNDCHAFAITIGSMDHAHCHTFIEMPTIRAGADGQKAQVGACKRADCQHNEQLECQAPAIRVGPDADMADCMTYTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F857</accession>
    <name>F4F857_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalamin (Vitamin B12) biosynthesis CbiM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_10500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731889.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10500"/>
    <dbReference type="EnsemblBacteria" id="AEB43218">
        <property type="protein sequence ID" value="AEB43218"/>
        <property type="gene ID" value="VAB18032_10500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10500"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_2_1_11"/>
    <dbReference type="OMA" id="PWGTSGH"/>
    <dbReference type="OrthoDB" id="1632785at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="239" mass="24079" checksum="DFE0FCF4C22228B5" modified="2011-06-28" version="1">MENLAMHISNGIINGPVAALFAVIALVAMAVAVHRGRQDLDDRLAPMAGLVAAFIFAVQMLNFPIFTAGVSGHLLGGALAAMLVGPWVGALCIAVVLVVQALVFGDGGVAMLGLSITNMGVIAVAVAYLLIALLLRVLPRTPAGLAVTAFVAALISVVVAAMGFVLQYWLGGTADLGGNLAGLAGTMAVSHLFIGIGEGLITATTVVTVAKVRPDLVYALRAARKPVGPASVPAVGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F877</accession>
    <name>F4F877_MICM1</name>
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        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731909.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10600"/>
    <dbReference type="EnsemblBacteria" id="AEB43238">
        <property type="protein sequence ID" value="AEB43238"/>
        <property type="gene ID" value="VAB18032_10600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10600"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="HLTACHY"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="329" mass="36193" checksum="596EAA4CE1A2A435" modified="2011-06-28" version="1">MPPSDDVVLRVENLVKHFPVKGRIPFVSGGVVKAVDGVSFDLRRGETLGVVGESGCGKSTLARMLVGLEQPTSGAVRFGKSVVHQAKGRELRALRRRIQIVLQDPYTSLNPRRTIREILLQPFEIHPDVLDRRRRVERIKELLDLVGLDASLHLDRYPHQFSGGQRQRIGIARALALNPDVIVCDEPVSALDVSVQAQVVNLLERLQDELGVAYVFIAHDLSVVRHISDRVAVMYLGKLVETGPEIDLYESPKHPYTSALLSAVPVPDPAGRRQRQRILLAGDPPSPVNPPSGCRFRTRCWQATDTCATTEPPLAAGAHPVACHYPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F896</accession>
    <name>F4F896_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_10695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10695"/>
    <dbReference type="EnsemblBacteria" id="AEB43257">
        <property type="protein sequence ID" value="AEB43257"/>
        <property type="gene ID" value="VAB18032_10695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10695"/>
    <dbReference type="eggNOG" id="ENOG5032Y4S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175587_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021277">
        <property type="entry name" value="DUF2610"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11020">
        <property type="entry name" value="DUF2610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="99" mass="10713" checksum="F96A392BDD4E0724" modified="2011-06-28" version="1">MIDCQFGTARASFPLYVGEPAVGTHPMEQQSAWLQRVRGGSVPTEVMDAFATLFTIALENNVSFEELCAYAMEQATDNSETTDENDAAPTEADNDSADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8T5</accession>
    <name>F4F8T5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_29721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735663.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29721"/>
    <dbReference type="EnsemblBacteria" id="AEB47015">
        <property type="protein sequence ID" value="AEB47015"/>
        <property type="gene ID" value="VAB18032_29721"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29721"/>
    <dbReference type="eggNOG" id="COG3544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074343_0_0_11"/>
    <dbReference type="OMA" id="MTWMGMG"/>
    <dbReference type="OrthoDB" id="1714516at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="61"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="23784" checksum="F40D7F2AFB01384A" modified="2011-06-28" version="1">MPSAVQETAVEERAASAEPRPGSPMLRYLTLAMTALLLLGIGWTAATLYAGRTPGETSAEAGFARDMSRHHAQAVEMAMVAYAKGQDPAVRQIGYDIALTQQAQIGHMQRWLQEWDLLPTGSRPAMEWMPDGVTVDANGLMPGMATREEIASLHEAQGAEVDRLFLDLMIKHHIGGVHMADGVLDATDRPEVVRMAQSMKQGQQKEINELRKLQQGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F949</accession>
    <name>F4F949_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PASTA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_04755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04755"/>
    <dbReference type="EnsemblBacteria" id="AEB42077">
        <property type="protein sequence ID" value="AEB42077"/>
        <property type="gene ID" value="VAB18032_04755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04755"/>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092033_0_0_11"/>
    <dbReference type="OMA" id="EWYGDEQ"/>
    <dbReference type="OrthoDB" id="2231650at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="250" mass="25723" checksum="C290704EB4ED694B" modified="2011-06-28" version="1">MSERGEEQPDDRTRPLPPPAGDPDDTAVLGGTPPEGTEADATVVVPPTPRPQLWSGRAEVRPPGPGDDRELTAGEWYGDEQAGRRWWLPILWGIVLLLLLGALGVGLWLARQAVDEDDSPPPSPQPTSTAPTSASASPTRSPSAAPTTSAAPTGLPMPPLVGLSEDAARARLEALDLEPEVVYRPSDQPAGTVIATDPGQGEPVQPGDVVRLVVATPSPSTTAPTTAPTTTDPTTTGPTTDPTATASPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9C0</accession>
    <name>F4F9C0_MICM1</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731985.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10980"/>
    <dbReference type="EnsemblBacteria" id="AEB43314">
        <property type="protein sequence ID" value="AEB43314"/>
        <property type="gene ID" value="VAB18032_10980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10980"/>
    <dbReference type="eggNOG" id="ENOG50316T4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1170268_0_0_11"/>
    <dbReference type="OMA" id="HRIAVYD"/>
    <dbReference type="OrthoDB" id="1505666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="26135" checksum="0149857454CC272A" modified="2011-06-28" version="1">MGWLQRVLGGRQVEHDPGRQEALLQQVRHGFGSRSQVRARDQIEEITRLLDDEDGLVVATRIVREVADAAHTDLLAQAADLHRRTGYRLVVDRRNYRVLWREAASALRWPLFDPPGGLHPYVQVAAAATVLGDRASRVVKATDPAPVLSAVFELFDLTTTGWEYGRVRPDTDGAELVLRLISAARQINAALSDPPPLPQPVRELMRRNNTTNVYDPAGHGVVGAINLGGELRPALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9P8</accession>
    <name>F4F9P8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23630"/>
    <dbReference type="EnsemblBacteria" id="AEB45824">
        <property type="protein sequence ID" value="AEB45824"/>
        <property type="gene ID" value="VAB18032_23630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23630"/>
    <dbReference type="eggNOG" id="ENOG50322KP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137629_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="25600" checksum="C358AE8AC79E3A40" modified="2011-06-28" version="1">MVQGNADDAATTLAALGRLRERAHRRAHGGAWLPALGCAVLLLASAALYRHPLTQPHSIDAKHPFWAGLPDEQVNPVASYLFWFLGTPLLFAVIALWYAWRARRHGVRVGWPSATVTGLGVLVLLAVLAAVPVGPVPDGLVSASGPYWTGLLTPLLPLAAAVIVLGRAEHSRGLVAAGIWIAALTAWLCISFPLGHLPGWASVLIGGGGAGGQLSLRPAHYLVLMALPLLVVAAVNLATARRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9R5</accession>
    <name>F4F9R5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734493.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23715"/>
    <dbReference type="EnsemblBacteria" id="AEB45841">
        <property type="protein sequence ID" value="AEB45841"/>
        <property type="gene ID" value="VAB18032_23715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23715"/>
    <dbReference type="eggNOG" id="COG3285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_1_0_11"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="323" mass="36295" checksum="1D1AE28B815E7668" modified="2011-06-28" version="1">MASTAEEIQVGRRTVRVSSPDKPYFPERGLTKLDVVRYFLAVGDGILRALRDRPTMLERWPRGVFEGATIATRQDNRGDAFYQKRVPSGAPGWVGTAHITFPSGRTADEVAPGELAVVIWAVNLGTLRFHPWPVTRADVERPDQLRIDLDPMPGVGFDQVVPVAHEVHRFLDELGLTGYPKTTGGRGLHVYVPIEPRWSFGDCRRAVLALGCELQRRRPDLVTTTWWREQRDRPVFIDYNQMARDHTMASAYSIRPTPQALVSAPLDWAELDDVRPEDFDVVSMPARFAERGDPHAGLDEDRFSLDPLLALADREGLAAPPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9T0</accession>
    <name>F4F9T0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_23790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23790"/>
    <dbReference type="EnsemblBacteria" id="AEB45856">
        <property type="protein sequence ID" value="AEB45856"/>
        <property type="gene ID" value="VAB18032_23790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23790"/>
    <dbReference type="eggNOG" id="COG3743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1106506_0_0_11"/>
    <dbReference type="OMA" id="QWLFVIL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="302" mass="30641" checksum="A24F433DF6F4A371" modified="2011-06-28" version="1">MIDSVGNWLILLVVLLVGLAGGWVLLRSRRGEPPASTHPTTSQAPVPASRQPADTEQSSPGGQPASSEPTPSVSAEPVATTDAPTPVATIDTTAPVATTDTPESVATTDTPEPVATTDTAEPVATTSVAEPDSATEIPEPATTTDASEPATTADTAVAAGTTAEPESAPAVSVPDGPAEQTVEETASARPAVATPPVRRKATTPRPRTRATPAATTDDAPAAHAPALDASDAVDDFRRIQGVGPKMAAALHGAGIRTYQQLAELDEATLRDTIRGAGLRATASLVTWPQQAKILSRQPGDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA04</accession>
    <name>F4FA04_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_00155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735761.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00155"/>
    <dbReference type="EnsemblBacteria" id="AEB47115">
        <property type="protein sequence ID" value="AEB47115"/>
        <property type="gene ID" value="VAB18032_00155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00155"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_6_11"/>
    <dbReference type="OMA" id="YRHFVVD"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="12"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="294"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="7">
        <location>
            <begin position="632"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="712" mass="76614" checksum="E69BBBA52B13D9A5" modified="2011-06-28" version="1">MVVNSPSERVLAGLDPEQRSAVTAPAGPVCVLAGAGTGKTRAVTSRIAYRALTGEISARHVLAVTFTARAAAELRHRLAQLGVAGVQARTFHAAALRQVRYFAPRLLDGRAMPELLDSKVRLVTLAAARAGLRADRTAARDLAGEIEWAKSSLVEPGEYVVAAAKALRETPHEPVKVAEVFAAYEKLKRTTGVIDFEDVLRAAVWGIEEHADVAEQVRNQYRHFVVDEYQDVNPLQQRLLDAWLGGRDDVTVVGDASQTIYSFTGATSSYLVDFPRRHRGATVVRLVRDYRSTPQVVGLANAVISQARGTEARLRLELVGQRPAGPAPEVRIFTDEAAEANAVAARCRALVDAGTPAHEIAVLFRTNAQSEAYEKALAESGVPYVVQGADRFFERPEVRQAMVAMRAATRSIPGETPLAAAVVEALAAVGWTPDSPPPGGAARERWEALAALVQLAEEYAATPQLMPLGAAATVERPVTLADFTDELARRAAQQHAPTVDGVTLASLHSAKGLEWDAVFLVGLAEGTLPTTYARTAEQVEEERRLLYVGITRARQWLWLSYASARSPGGRARRPCRFLPQLSASGTTERAGGTRSAPGAQRSATRIVSCRICGTTLLAGPDRKLGRCATCPSDIDDELHERLREWRSRVAQTQKVPAYVVFTDATLVALAERRPGRAEELVAIAGIGPRKLGLYGEAVLALVKGAAVDEICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA43</accession>
    <name>F4FA43_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase (Membrane anchor subunit) (Succinic dehydrogenase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00350"/>
    <dbReference type="EnsemblBacteria" id="AEB47154">
        <property type="protein sequence ID" value="AEB47154"/>
        <property type="gene ID" value="VAB18032_00350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00350"/>
    <dbReference type="eggNOG" id="ENOG502Z8CG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000864_0_0_11"/>
    <dbReference type="OMA" id="DRWWLAP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="28885" checksum="C91AD31424300292" modified="2011-06-28" version="1">MRTDRWWIAPLITVIGLSAWIAYATVRVFMHKWYWVEQYHYLTPFYSPCVTDRCIPEASHFGQYLPGWWIIPDAAFTLPFLLLFRLTCYYYRKAYYRSFWLSPPACAVPDGHASYSGETRFPLIVQNSHRYFFYFAAIISLINTWDAIAAFRSPEGFGFGLGNLILLGNVVMLWAYTISCHSCRHIIGGRLKHFSKHPVRYRAWGYVSWLNVRHMQLAWITLGTLALTDFYVMSVAAGWISDLRFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA73</accession>
    <name>F4FA73_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase (Acetyl-transferring)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_05040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730808.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05040"/>
    <dbReference type="EnsemblBacteria" id="AEB42134">
        <property type="protein sequence ID" value="AEB42134"/>
        <property type="gene ID" value="VAB18032_05040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05040"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_1_0_11"/>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="OrthoDB" id="1248201at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="67"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="391" mass="43156" checksum="BA03ABC6CAA16E92" modified="2011-06-28" version="1">MAKGDPGASTRGRRAAPRSRKAATGDPELVQLLTPSGERIDSVTGPDGVEYRVDFTDEEYRGLYRDLVLVRKLDAEATALQRQGELGLWASLLGQEAAQVGSGRALRAQDMAFPTYREHGVLYCRGIDPIMPLGLFRGVDQGGWDPNEFKFNMYTIVIGAQTLHATGYAMGVAMDGKTGGEDGEAVIAYFGDGATSQGDVNEAFVWASVFNAPLVFFCQNNQYAISEPLERQTRVPLYRRAAGFGFPGVRVDGNDVLATYAVARHALDNARNGQGPSLIEAYTYRMGAHTTSDDPTRYRIASEVEAWQAKDPIARMKAFLEREKIADSDFFAEVDEQARREAIDLRERVLAMPNPEPVTMFDHVYPNGSPLLDEQRAQFNKYFDSFEGSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAN5</accession>
    <name>F4FAN5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_17740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733305.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17740"/>
    <dbReference type="EnsemblBacteria" id="AEB44650">
        <property type="protein sequence ID" value="AEB44650"/>
        <property type="gene ID" value="VAB18032_17740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17740"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069543_3_0_11"/>
    <dbReference type="OMA" id="SALYNHV"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="221" mass="23688" checksum="00DD579F5270856C" modified="2011-06-28" version="1">MPRPRQALLSRERIVETAAALIDADGLDAFSTRRLAAALGVRGPSLYNHFATKDEILDAVADSITGQVDVSFFGEVDWREALRRWGHGFRAALAAHPNIVPHLAQGPGRRPAALAMADAVYGGLVAAGWSPARATHIGALMRYFVTGSALGSFARGFVEDPGLYAEQYPHLSQAHRLAEHQQRVDEGAFALGLEALIDGLSHTYERLVGPLAPLPPEGGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAP1</accession>
    <name>F4FAP1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733311.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17770"/>
    <dbReference type="EnsemblBacteria" id="AEB44656">
        <property type="protein sequence ID" value="AEB44656"/>
        <property type="gene ID" value="VAB18032_17770"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17770"/>
    <dbReference type="eggNOG" id="COG4106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="OMA" id="TGRWRTD"/>
    <dbReference type="OrthoDB" id="1186918at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="275" mass="30233" checksum="49A9C551A3C39CC9" modified="2011-06-28" version="1">MTRDKAAPPGIDTSIPSVARVYDFFLGGKDNFEVDRKVAEHALRITPDGPAAGQANRAFLRRVIRFLVTEAGIDQFLDIGSGLPTQGNVHEVATEHNPKARVVYVDNDPIVLAHGRALLAEEGTATVIQADVRAPQEILNNPEVRRFLDFDRPIGLLLFAILHHVGDDEQPRALAAELIDALPSGSYVAISHFRDPGERDPEGSRKAREVERVFNESLGTGRWRTDEEILAFADGLTVLEPGLVPLAEWRPESGTPTPQQTDTYHTFVGLLARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAP6</accession>
    <name>F4FAP6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-oxalocrotonate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733316.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17795"/>
    <dbReference type="EnsemblBacteria" id="AEB44661">
        <property type="protein sequence ID" value="AEB44661"/>
        <property type="gene ID" value="VAB18032_17795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17795"/>
    <dbReference type="eggNOG" id="COG3971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060136_4_1_11"/>
    <dbReference type="OMA" id="CIEWMAH"/>
    <dbReference type="OrthoDB" id="1314120at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="264" mass="27176" checksum="2E9BA78F1D6DB18E" modified="2011-06-28" version="1">MSADIKGAAAALRQAYASGVACEPLRDDLLPAGDLTAAYAVQQAQVSDWLAEGRRLVGAKVGLTSRAVQEAFGVFQPDFGVLFADMAVPDGAEIDPRTLLQPRVEAEVAFVLGRDLPYDQVTVADVVRATDHLLPAIEIVDSRIANWDISIVDTVADNASSGRYVLGTSPRRLGEVDLRLCGAVLEQGGEPVSVGAGAACLGNPLHAVAWLAGTLAANGRPLRAGDTVLSGALGPMVAVTPGAAYEARISGLGSVRACFSKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB39</accession>
    <name>F4FB39_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_00500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735829.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00500"/>
    <dbReference type="EnsemblBacteria" id="AEB47184">
        <property type="protein sequence ID" value="AEB47184"/>
        <property type="gene ID" value="VAB18032_00500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00500"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1734230at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="112"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="318" mass="33487" checksum="8C5FC64983A67DE9" modified="2011-06-28" version="1">MSDFETVASSENQAARRGVSGEPGTPGRVGQPGRPRSLAGDAWRDLRRKPIFWISLVLVLLVTAMAVAPGLFTSNDPADCVLSRQHAAPSGGAIFGYDFQGCDTYARAVYGARASLLVGALSALLTGVIALVVGMLAGYFGGWVDAVLSRIVDIVLGIPLLLAAIVLLKRVASDSATVRLGSVIFVLAVLGWTTAARVVRSSVITARQQDYVAAARMLGAGNGRIMWRHILPNALAPAIVVLTIALGSFIAAEATLSFLGIGLKEPTISWGIDINNGRVHMRESATPLVVPSTFLALTVLAFIMLGDAIRDAFDPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBP9</accession>
    <name>F4FBP9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_11985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732180.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11985"/>
    <dbReference type="EnsemblBacteria" id="AEB43511">
        <property type="protein sequence ID" value="AEB43511"/>
        <property type="gene ID" value="VAB18032_11985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11985"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_16_3_11"/>
    <dbReference type="OMA" id="MDGIWLA"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="449" mass="45366" checksum="CA56AB3090DA6102" modified="2011-06-28" version="1">MSHSTPAVDQVASLRRIAALALPALVVLAAEPLYVLVDTAVVGHLGQVPLAAVAVGGTVMTLTAWVGTVVAYGTTGRAARRFGAGDRAAAVAEGVQASWLALALGVLVAVGMQVGGPALTGALAGGGDVGRAAGEWLRIAAFGAPGLLLAAAGNGWLRGVQDTRRPLWFVVGPNLLSAVLCPVLVYPVGMGLNGSAVANVIAQTLSGVLFAAALVSERVALRPRPRVIGQQLVLSRDLLIRGLAFQASFLSATAVAARFGAAAVGAHQIAVQLWFFAALVLDALAIAAQALVGAALGAGDAVAASMLAKRIGRFGAVCGAAFAVLAAAGAGVVPTWFSSDPAVHEQALVAWPWFVVMLPLAGVVFALDGVLIGAGDIRYLRNLTVVGALGGFLPAIWLSHAFALGLGGIWAGLLLFVVIRLIGLLLRLRSGAWAVTGAVRTEGRARTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC69</accession>
    <name>F4FC69_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_00820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00820"/>
    <dbReference type="EnsemblBacteria" id="AEB47248">
        <property type="protein sequence ID" value="AEB47248"/>
        <property type="gene ID" value="VAB18032_00820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00820"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_11"/>
    <dbReference type="OMA" id="SVAMTGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="406" mass="43288" checksum="2A713080EF49B92D" modified="2011-06-28" version="1">MARTRTLTGVTSTDVDPLVNRMRPFGTTIFAEMSALAVRTGAVNLGQGFPDTDGPPEMLAAAAEALRSGRNQYPPGPGIPELRAAVAAHQHRFWGLEYDPDGEVVITAGATEAIAAAILALCEPGDEVVCFEPYYDSYAASIALAGAVRRPVTLRPGPDGRYAFDPAALRAAFGSRTRLVLLNSPHNPTGKVFTPAELALVAELCQEHGAYAVTDEVYEHLVFTDAASEHVPLASLPGMRERTLRISSAGKTFSCTGWKVGWASGPAALVSAMLRVKQFLTFVNAAPLQPAVAVALGLPDAYFTEFRAGMQARRDQLIGGLVDAGFEVLSPEGTYFVTADITALGGTDGVEFCRSLPERCGVVAVPTQVFYDDPEAGRRLVRFAFCKRPELLAEAVSRLGGATWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC73</accession>
    <name>F4FC73_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_00840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735897.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00840"/>
    <dbReference type="EnsemblBacteria" id="AEB47252">
        <property type="protein sequence ID" value="AEB47252"/>
        <property type="gene ID" value="VAB18032_00840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00840"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033198_0_1_11"/>
    <dbReference type="OMA" id="WWYYARR"/>
    <dbReference type="OrthoDB" id="1217595at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="455" mass="48889" checksum="550E8621D9E22136" modified="2011-06-28" version="1">MTTTSAQPEAVQEETLDRRPGRWIGHWAPEDHTFWRTTGNRIARRNLIWSIFAEHIGFSVWLLWSIVVVRLGDAGWQLSTSQALWLTAVPSGVGALLRLPYTFAVPVFGGRNWTIVSALLLIVPCAGLAWAVERPEIGFPVLLLIAATAGFGGGNFASSMANISFFYPEREKGWALGLNAAGGNIGVAVVQFLVPQVIVLGGGLALARAGLMYIPLAVIAAVCAYLFMDNLVEAKADVRPVWSSLRHRDTWIMSLLYIGTFGSFIGYSAAFPTLLTSVFGRPDVALTWAFLGAAVGSFCRPFGGRLSDVVGGARVTMVSFVLMAIGALAALWSVEQRSLGVFFVAFLLLFVATGVGNGSTYRMISRIFQVKGEELGGSPEVMLAMRRQAAGALGIISAVGALGGFLVPICYAWARSTYGGIQPALRFYVGFFLVLLLLTWAAYLRPGARLARAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC95</accession>
    <name>F4FC95_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="8" type="ordered locus">VAB18032_00950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00950"/>
    <dbReference type="EnsemblBacteria" id="AEB47274">
        <property type="protein sequence ID" value="AEB47274"/>
        <property type="gene ID" value="VAB18032_00950"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00950"/>
    <dbReference type="eggNOG" id="COG2022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062233_1_0_11"/>
    <dbReference type="OMA" id="PHNFQLI"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="9"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="261" mass="26945" checksum="C96773A809EBD1F2" modified="2011-06-28" version="1">MTMDSDGFEIGGTRFGSRLILGTGGAANLHVLEQAIRASGTELVTLALRRVDTVPGGSGGLLDLLDRCGVRLLPNTAGCYTAGEAVKVAHLARDAFDTDWVKLEVIGDERTLLPDGVELLRAAEELVADGFTVLPYTSDDPILARRLADVGCAAVMPAGSPIGSGLGVSNPHHIRLIRQSVDVPVILDAGIGTASDAALAMELGCDAVLLASAVTRAADPVAMATAMRHAITAGRLAAGAGRIPRRFHALASTPDEGRPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCI3</accession>
    <name>F4FCI3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05920"/>
    <dbReference type="EnsemblBacteria" id="AEB42310">
        <property type="protein sequence ID" value="AEB42310"/>
        <property type="gene ID" value="VAB18032_05920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05920"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042538_2_1_11"/>
    <dbReference type="OMA" id="DLIEYAM"/>
    <dbReference type="OrthoDB" id="1869158at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="351" mass="39071" checksum="97F8D8F324253384" modified="2011-06-28" version="1">MADHTLPTRHADENRPVRIVTDILPALRDACPVPSRQSPYADEVQRWLMGWLPQTGLPLDEPARQRLAGARFAHYAGRLYPDATEADLRVLSALFTWFFLVDDACDGPGRLELAEIRGLRDGAVLLLQGRSRPRHPGLRGPLRRLLVNAWREPHRRMPTRWRLRFADAVARHLDGAWQEATNKSRGHAPGVTEYVALRRATSAADVSYPLAEFVTGRPLPDAVYHHPLLRELRDLGNDLLSWYNDLASLASDAATSGGHNLVLATATERQVRVDDAVEVVTRRWHESMRRFVDRRAAVPSFGPALDAAVTTHLDGVSRAVRGTIDWTLESTRYVGKEGHLINASGSKGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCI8</accession>
    <name>F4FCI8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_05945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05945"/>
    <dbReference type="EnsemblBacteria" id="AEB42315">
        <property type="protein sequence ID" value="AEB42315"/>
        <property type="gene ID" value="VAB18032_05945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05945"/>
    <dbReference type="eggNOG" id="COG3554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055771_2_1_11"/>
    <dbReference type="OMA" id="DEWRRIG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009467">
        <property type="entry name" value="Glycolipid-bd_prot_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06475">
        <property type="entry name" value="Glycolipid_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="22503" checksum="DFEEB91188D17660" modified="2011-06-28" version="1">MPTMSKSLLWTRIDTAGAEHALADDSHGLAAHGTQVAADPIPYTCRYQLLTDPQWASVRVEVEVEGAGWRRSVRLERAVDRWRVTAAEQGDLDAALAAAGHAPAGLPGVEDPDRLADALDVDLGGSPLFNTLPVRRLRLADQAADTSYPLTVVWVLVPSLTVLPAEQVYTGLGPTRFRYASGGFSADIEMDADGFVRHYPGLAQLSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCQ9</accession>
    <name>F4FCQ9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monovalent cation/proton antiporter, mnhg/phag subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_12195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12195"/>
    <dbReference type="EnsemblBacteria" id="AEB43553">
        <property type="protein sequence ID" value="AEB43553"/>
        <property type="gene ID" value="VAB18032_12195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12195"/>
    <dbReference type="eggNOG" id="COG1320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_0_5_11"/>
    <dbReference type="OMA" id="LKLILIW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="129" mass="13324" checksum="1EDBA59FD94AE456" modified="2011-06-28" version="1">MTPPAAGPGGIPPAVDWALTVTDVADWLGAVSLVAGALLSLAAAIGVLRFPDTLSRMHAATKPQVLGVLLLLLGLVLRLRTLSDLGMVALVGVFQLATAPVAAQMIGRAAYRTGRFDRGLLDADELADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCU2</accession>
    <name>F4FCU2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12360"/>
    <dbReference type="EnsemblBacteria" id="AEB43586">
        <property type="protein sequence ID" value="AEB43586"/>
        <property type="gene ID" value="VAB18032_12360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12360"/>
    <dbReference type="eggNOG" id="COG3885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090899_0_0_11"/>
    <dbReference type="OMA" id="SGRAPWQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="26689" checksum="C1A68786647AAF79" modified="2011-06-28" version="1">MAATSGARLRPPDRYGCRVPLVAAAVCPHPPLLIPEVAGAAATELDDLRRACDTAVTRLVDSGADELLVVGDGPDTHRYDPPFHGSLAAYGLPVEPTVGRPGPGSRPDLPLSLTIGAWLLGRSRSESVPVVSAMYAVAPQTDPVSCAQLGAGWGGDRNWALLVLGDGSACRGAAAPGYADPRAEAYDSGVAEALADADLDALLDLDPELSAQLRVVGRAAWQVLAGAARAAGGDWRGELSYHAAPYGVAYFVATWERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD43</accession>
    <name>F4FD43_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_24875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24875"/>
    <dbReference type="EnsemblBacteria" id="AEB46073">
        <property type="protein sequence ID" value="AEB46073"/>
        <property type="gene ID" value="VAB18032_24875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24875"/>
    <dbReference type="HOGENOM" id="CLU_2995428_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309268" evidence="2">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="57" mass="5573" checksum="51B6805423D8598F" modified="2011-06-28" version="1">MGRTVKIFALAATTAALVLFGASVAQADTTAPATATVVPSSPSPSPTATTAGNNPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD85</accession>
    <name>F4FD85_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_25085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734767.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25085"/>
    <dbReference type="EnsemblBacteria" id="AEB46115">
        <property type="protein sequence ID" value="AEB46115"/>
        <property type="gene ID" value="VAB18032_25085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25085"/>
    <dbReference type="eggNOG" id="COG3188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302839_0_0_11"/>
    <dbReference type="OMA" id="QWFGFQA"/>
    <dbReference type="OrthoDB" id="191946at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.870.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023309">
        <property type="entry name" value="Endo-1-4-beta-glucanase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027390">
        <property type="entry name" value="Endoglucanase_F_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000556">
        <property type="entry name" value="Glyco_hydro_48F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02011">
        <property type="entry name" value="Glyco_hydro_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00844">
        <property type="entry name" value="GLHYDRLASE48"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313816" evidence="6">
        <location>
            <begin position="33"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="966" mass="104088" checksum="F26B7DB762A1D20D" modified="2011-06-28" version="1">MRNLARRRRLAWLGAAALAIGGVTVPAGAAQAAPACDVVYETNDWSNGFTANITLKNLGDPVNGWTLRFAFPGNQRVTNGWSARWSQSGNQVTAVNEAWNGSMATGASTTIGFNGSYTGSNPKPTSFSVNGVTCGGVAQQPPTVSLSVPAGPFTAPATVPLTATASDPDGTIARVEFYRNGLLVNTDTTAPYAYTLESLPAGDYTVQARAYDNSGLSAIAERSFSVTASTAPAVVATPTALTVPEGGSSTFNVKLSRAPSANVSVSLTRTGDTDITVPSTPLTLTTSNWNSGVDVTVQAAEDADTVGGTATITASAAGHTPATVTVTEIDNDVPGGDGEYVQRFLTQYNKIKNSGYFSPEGVPYHSIETLIVEAPDHGHQTTSEAFSFWLWLEAYYGRVTQNWAPFNNAWTVMETYIIPSTADQPTAGSAGDATYAAENDLPSQYPSQLNANVPVGKDPLRAELQQTYGTGSIYGMHWLLDVDNVYGFGRCGNGTTRPAYINTFQRGTQESVWETVPHPSCDTFAHGGPSGYLDLFIKESGTPAKQWKYTNAPDADARAVQAAYWALTWAKEQNKQADVAATVTKAAKMGDYLRYALFDKYFKRIGNCVGATQCPAGNNRESAHYLLSWYYAWGGAYETSQNWSWRIGSSHSHFGYQNPFAAWALTNVNELKPRSSTAAADWNNSLTRQLELYTWLQSAEGGIAGGATNSWGGHYGTPPAGTATFYGMFYDEDPVYNDPPSNQWFGMQAWSMQRIAELYLVSGDARAKALLDKWVPWAIANTTLGEDWSIPADLKWTGQPNNWNPTNPQPNTNLHVEVIAKGQDVGIAASYARTLIAYAAKSGNVAAKNTAKGLLDALHGESDAQGVSTVEKRGDYRRFDDVYDASTGQGLYIPQGWTGRMPNGDVIAPGKSFVDIRSFYKNDPAWPKVQAYLDGGPEPEFRYHRFWAQADVAMAYADYGKLFPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDD7</accession>
    <name>F4FDD7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proton-translocating NADH-quinone oxidoreductase, chain M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_01320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735984.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01320"/>
    <dbReference type="EnsemblBacteria" id="AEB47348">
        <property type="protein sequence ID" value="AEB47348"/>
        <property type="gene ID" value="VAB18032_01320"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01320"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_11"/>
    <dbReference type="OMA" id="GHMGFVL"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="141"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="510" mass="51960" checksum="58299B91A31CC5F6" modified="2011-06-28" version="1">MSFGEFLLVAVLALPALGALAVAALPRDLPARVAGTVAAALTLVAALALAVDRAGSWTAYAATTPAVRPWHALDLPWVPGLDLRFHLGVDGISWPLVVLTALLTLLCCGYTCWRVPAGGSGRALVALLLVVEVGILGTFLALDLVLFFLFFEIVLLPMYAIIVGWGGDGTDPAAVAARRRAARKFALYTLFGSVLLLVGVYVVVAAAGTADIVALTGGNGLARGTQLAAFTLLAVAFAVKSPLWPLHSWLPDAHTQAPTVGSVLLAGVLLKMGTYGLIRVAVGVAPEGARWAAPVLGVLAVAAILIGSLVCLAQTELKRLIAYSSVGHMGFVLLGIATLTATGIQAALIGNVAHGIITGLLFFLAGAIKDRTHTGALRELSGLRETAPRLSGLLAFAAVASLGLPGLAGFWGEAFAVVAAVEVGGALWITLAVLAAFGGALTAAYLLRLLRQVTHGRATPAVAGLKPGLAGAEVAAWAPLVLLALAVGLAPTLVLGVAEAPVTALVEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDF3</accession>
    <name>F4FDF3_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proA</name>
        <name evidence="9" type="ordered locus">VAB18032_01400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736000.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01400"/>
    <dbReference type="EnsemblBacteria" id="AEB47364">
        <property type="protein sequence ID" value="AEB47364"/>
        <property type="gene ID" value="VAB18032_01400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01400"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_11"/>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="OrthoDB" id="223669at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="5"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="413" mass="42645" checksum="5CBDD6BCDF4D1E86" modified="2011-06-28" version="1">MSVSEQARRARTAGETLAVTTRTAKDAALNAMADALVARTPEILAANAADLAAGREAGLSAAVLDRLALDEGRMAGIADALRQMAALPDPVGEVVRGSTLPNGLELRQIRVPFGVVGIVYEGRPNVTVDAAGICLKSGNAALLRGSSSAAHSNAALVAVLRDAIVSAGLPADAVQLLDSSTRDSVKELMRARGLVDVLIPRGGASLIRTVVEESTVPVIETGVGNCHVYVDDAADLPMAVSITLNAKTQRLSTCNTAESLLVHAAVADDFLPPMLAAFAEAGVTVHGTAEVARFSDAVVPATDEDFATEYLSADISVTVVDSLDAAVAHIRRYGSGHTEAIVTDSQSAAREFVARVDSAAVMVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLPELTSTKYVVTGTGHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDT0</accession>
    <name>F4FDT0_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ordered locus">VAB18032_12485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732280.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12485"/>
    <dbReference type="EnsemblBacteria" id="AEB43611">
        <property type="protein sequence ID" value="AEB43611"/>
        <property type="gene ID" value="VAB18032_12485"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12485"/>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_2_11"/>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="OrthoDB" id="1862614at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="14989" checksum="42C00E6E71F7928C" modified="2011-06-28" version="1">MRAVVQTVGRASVTVDGEVVGAITDGLLVLIGVTHTDTVETARTMARKVHELRILDDERSAAEVAAPILVVSQFTLYGDARKGRRPSWTAAAPAEVAEPLVDAVVEALRQRGAPVQTGRFRAHMLVESVNVGPRTILLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDU6</accession>
    <name>F4FDU6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_12565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732296.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12565"/>
    <dbReference type="EnsemblBacteria" id="AEB43627">
        <property type="protein sequence ID" value="AEB43627"/>
        <property type="gene ID" value="VAB18032_12565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12565"/>
    <dbReference type="eggNOG" id="ENOG5032Y9G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184972_1_1_11"/>
    <dbReference type="OMA" id="CGHHARA"/>
    <dbReference type="OrthoDB" id="1938183at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="77" mass="8344" checksum="EBBF345B814ABB9D" modified="2011-06-28" version="1">MTPTLTPPPETVSPPAADERCDRCNAAGKLRITLAGGSELVFCGHHANKYAEDLVKITVRYATDPEFSWRGADLISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE27</accession>
    <name>F4FE27_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733551.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18970"/>
    <dbReference type="EnsemblBacteria" id="AEB44896">
        <property type="protein sequence ID" value="AEB44896"/>
        <property type="gene ID" value="VAB18032_18970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18970"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109811_1_0_11"/>
    <dbReference type="OMA" id="TYLNCEG"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="17018" checksum="BC5A06648B87892D" modified="2011-06-28" version="1">MDLRFKIAGRISRPVHEVFEAVVDPEQLSHYFTTGGAKGRLTAGATVSWDFADFPGAFPVEVVEVQQDRRIVLRWAADDGEESTGAYQTTVTMEFEPLGEDRTLVTIAEEGWRPTPQGQRASYGNCEGWTNMLCCLKAWLEHGIELRTGFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE73</accession>
    <name>F4FE73_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19200"/>
    <dbReference type="EnsemblBacteria" id="AEB44942">
        <property type="protein sequence ID" value="AEB44942"/>
        <property type="gene ID" value="VAB18032_19200"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19200"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_0_11"/>
    <dbReference type="OMA" id="GFVKKHD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="124" mass="13213" checksum="BBED27CA8498403F" modified="2011-06-28" version="1">MSVLVDDQAKALAFYTGVLGFIKKTEVPLGEYSWLTVVSPEDPEGVELVLEPDQHPAALAYKKALVADGIPVTMFTVADVSVEYERLTAQGVTFTQPPLDAGTVTTAVFDDTCGNLIQIVAPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEB2</accession>
    <name>F4FEB2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734830.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25400"/>
    <dbReference type="EnsemblBacteria" id="AEB46178">
        <property type="protein sequence ID" value="AEB46178"/>
        <property type="gene ID" value="VAB18032_25400"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25400"/>
    <dbReference type="eggNOG" id="ENOG502ZN3G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056536_0_0_11"/>
    <dbReference type="OMA" id="THEPTRA"/>
    <dbReference type="OrthoDB" id="1450979at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="368" mass="41496" checksum="D2347E318F0E0FAB" modified="2011-06-28" version="1">MARRVYLHIGAPKTGSTYVQNVLWSNRDRLAQTGILLPGSAVAQDQAMADLRAAPWRDPEVYWTWDRLAEKARQWPGDVIISNEGLGAATGEQAARAVTSLGAGEIHVIVVGRDLWRTFPSFWQQSVRARSGWRFEEFLRAVEEGRCEVFWENHTAVRMLRRWGDLVPAQRRHLVTVPAPGAPPEVLWHRFAGIVGIDDGRCELTVPAANPSLGAAEIELLRRVNRKLGDRYPLRTPYRRVVHRHLVDAVLKQRAGQQRFGIGLDRADWVLDLAEAQIKELRDYPCQIVGDLDDLRPAKLTPAGTPDAVDDDHLLDVAIETIVDLLGHAHTLDERAEQQPDDVLTRLKNRAAGGVKRRLRRVIRRDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEF4</accession>
    <name>F4FEF4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_25610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25610"/>
    <dbReference type="EnsemblBacteria" id="AEB46220">
        <property type="protein sequence ID" value="AEB46220"/>
        <property type="gene ID" value="VAB18032_25610"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25610"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066403_0_0_11"/>
    <dbReference type="OMA" id="HPYVDVW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB46220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="262" mass="28548" checksum="85FC77B80821F6E3" modified="2011-06-28" version="1">MLAGNWRRRTVIPEVDAETDLVVEDADSGFCGAVVGFESGAVVLEDRHGKRRNFPLRPAAFLLDGRPVTLRRPAPAPVPAARRRTASGSIAVDGVRARVARASRIWVEGVHDAALVERIWGDDLRIEGVVVEPLEGIDDLDAAVREFGPAPHRRLGVLVDHLVPGSKESRIVARVTSPHVLVTGHPYVDVWQAVKPAALGIRAWPVVPPGRPWKEGVCAALGVAEPADMWRHILSRVNTYAEVETPLINAMERLIDFVTEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEK0</accession>
    <name>F4FEK0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_01790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736077.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01790"/>
    <dbReference type="EnsemblBacteria" id="AEB47442">
        <property type="protein sequence ID" value="AEB47442"/>
        <property type="gene ID" value="VAB18032_01790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01790"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_0_11"/>
    <dbReference type="OMA" id="NPEQQEC"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014298">
        <property type="entry name" value="RNA_pol_sigma-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02952">
        <property type="entry name" value="Sig70_famx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="151"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="254"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="315" mass="33829" checksum="DB581C1594A357B8" modified="2011-06-28" version="1">MTTFGFTHRPTGLTGPAARTPVNERGGAHAQQNAAGNLVNRGESSTRAGNRPHPNEPPHRPAVPGANAMPTGGGVATPSRPTMPAQARRSGGDAPVTDVPAAETAVIPAVTDPVNTSTGYPSRPDPSDPATEVWALVERAQAGEAEAFGLIYDRYVDTVFRFVYFRVGNRQLAEDLTSDTFLRALKRIGSFTWQGRDLGAWLVTIARNLVADHFKSGRYRLEVTTGDVLDADREDRGPEGSPEAAVVEHITNVALLTAVKRLNPEQQECIVLRFLQGFSVAETARAMGKNEGAIKALQYRAVRALARLLPDGFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FES2</accession>
    <name>F4FES2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731139.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42466">
        <property type="protein sequence ID" value="AEB42466"/>
        <property type="gene ID" value="VAB18032_06710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06710"/>
    <dbReference type="eggNOG" id="ENOG5031WM8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2959581_0_0_11"/>
    <dbReference type="OMA" id="MPHHHRE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="59" mass="6686" checksum="1F4EEB8D370B5658" modified="2011-06-28" version="1">MPHHHREPVDQAAERERQKQDAPRGRDWADEAAQARSADDPRARTPHDPTGRPSQGEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEV3</accession>
    <name>F4FEV3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06865"/>
    <dbReference type="EnsemblBacteria" id="AEB42497">
        <property type="protein sequence ID" value="AEB42497"/>
        <property type="gene ID" value="VAB18032_06865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06865"/>
    <dbReference type="eggNOG" id="ENOG50328IB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179261_1_0_11"/>
    <dbReference type="OMA" id="WIDGYVL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="86" mass="9809" checksum="8984DC3D12474FE4" modified="2011-06-28" version="1">MTTPRAGDLLRVGPEASVQFIRPILFRVIRVLDWATYDGWIWLEGYQLDSRGDAVARRSIFVMQAGLRTAPAPVVVGQPHFRSRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEV9</accession>
    <name>F4FEV9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731176.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06895"/>
    <dbReference type="EnsemblBacteria" id="AEB42503">
        <property type="protein sequence ID" value="AEB42503"/>
        <property type="gene ID" value="VAB18032_06895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06895"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_16_11"/>
    <dbReference type="OMA" id="LDRHEHG"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="166"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="30465" checksum="D24A519928048440" modified="2011-06-28" version="1">MSTGQQVRVWAPPVSGITEVLHARFTEHAYPMHTHGSWTLLVVDDGIVRYDLDRHEHGAFRQVVTLLPPGVAHNGSPATPGGFRKRVLYLDPEQLGDRLVGRAVDQPSFDDTALRRRIDLLHALVAAPGDEFAAEVQLAVVRDRLRAHLTRRTPQAPAVRDTRIARRLRELLDEHVVTGLTLRDAAEALHAHPTYLVRAFSTAYGLGPHQYVISRRVDLARQLLREGRPAVEVAVATGFYDQAHLSRHFKRILGYPPGRYSTVRRITGASGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF49</accession>
    <name>F4FF49_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19260"/>
    <dbReference type="EnsemblBacteria" id="AEB44954">
        <property type="protein sequence ID" value="AEB44954"/>
        <property type="gene ID" value="VAB18032_19260"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19260"/>
    <dbReference type="eggNOG" id="ENOG5033U9R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821149_0_0_11"/>
    <dbReference type="OMA" id="LLWFRAR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045998">
        <property type="entry name" value="DUF5954"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19379">
        <property type="entry name" value="DUF5954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="34823" checksum="B6BFF0BBD2E0DB90" modified="2011-06-28" version="1">MVIRFRRLDDPVAVVTDHDAVQRAEAYPILRIGAPLFGHAIDLGGGRWRIHGLVEDTPQAARDALAHRLRERLVTATDADLVAELAAVGEVLDWQKVDEVTVGGRRHRVIRADTFARFGPAGPEPPRPTDLDPRQADTCDSFLGGADLIADPAAPTGVGAAVLKVELLPARYPKAEVSPAAYADSVAAVRSHPNGVLLPTRYAVAEQVAGVWQPSSRAVATPQQARELILFDFRWLTPRIANPGEAAAAEYRRAADDLEASRADEVSVRGRRLRVIRVETLLRFAADGPERPRPSDPDPEPPPEAHFARLRAEGRLPEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF50</accession>
    <name>F4FF50_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733610.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19265"/>
    <dbReference type="EnsemblBacteria" id="AEB44955">
        <property type="protein sequence ID" value="AEB44955"/>
        <property type="gene ID" value="VAB18032_19265"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19265"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069543_5_2_11"/>
    <dbReference type="OMA" id="FEFEFAL"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="236" mass="25360" checksum="55AA4F8F9394268D" modified="2011-06-28" version="1">MAEQAGTARRTPLSRERILRTAIALADAAGIGSLSMRNLAQELGVVPMALYKHVANKDELLDAMIDMVVGEIDTPMPDTEWKQAIRGRILSARSALQRHPWAALAIESRNMATPAILGYLDSVVATLRSGGLSADLAHHVMHAMGSRVLGFSQELFDTTRDAGRSGPSTAPQPAAMPPEVAARFPHLAEIATAASHDDASVVGSGCDDQFEFEFALDLLLDGIERLQQQGWTSAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF80</accession>
    <name>F4FF80_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733640.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19415"/>
    <dbReference type="EnsemblBacteria" id="AEB44985">
        <property type="protein sequence ID" value="AEB44985"/>
        <property type="gene ID" value="VAB18032_19415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19415"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860019_0_0_11"/>
    <dbReference type="OMA" id="AFRDPWV"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="315" mass="34524" checksum="395C94AC92817427" modified="2011-06-28" version="1">MLRLPDHWVWDSWYAQDDDGSWHAFFLRASRALLDPHRRHRRASIGHAVSTDLRSWQLVPDALVPADSPAWDDLATWTGCTVRGPDGRWYLFYTGVGRAEDGLVQRVGVAVSDDLTTWHRHGDGPLVEADPTWYELLDPQMWYEQAWRDPWVFPDPAGDGWHMLITARANQGPAAERGVIGHATSPDLLTWTVQPPLSAPAGFGHLEVPQVAVVDGQPLLLFCTNAVADGPEHQLWVVPAPTVQGPWDVAAAQPIALPNLYAPRLVPDGDGWSLIGFVDHVDGEFVGAISDPVPVHYQPGIGLVPRLPAATTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFB3</accession>
    <name>F4FFB3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, laci family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_19580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45018">
        <property type="protein sequence ID" value="AEB45018"/>
        <property type="gene ID" value="VAB18032_19580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19580"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="RANEWET"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="312" mass="33182" checksum="99B3D29FE4E07BBA" modified="2011-06-28" version="1">MLNGHPNVREQTRLRVQAAIAELGYRPNRAARALVTGRSQVIGVVAQNTTLYGPASLLAALEQTAAESGFAVSVGSVRDLDHRSISAVVERHLAHRVAGIVVIAPVESAGEALERLPNDVPLVTVDGDPRRPMPLVTVDQAAGARAATQHLLDAGHRTVWHVSGPSDWFDSAGRIEGWRSALLSAGVEIPPLVPADWSAAAGYRCGQMLARMPDVTAVFTANDHLALGVLRALHEHGRRVPDDISVVGFDDVPEAAYFIPPLTTVRPDFVAVARASLEMLLAQIETDSGGALRETIAPSLVSRQSVGPPPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFD8</accession>
    <name>F4FFD8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding domain 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25710"/>
    <dbReference type="EnsemblBacteria" id="AEB46240">
        <property type="protein sequence ID" value="AEB46240"/>
        <property type="gene ID" value="VAB18032_25710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25710"/>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063855_0_0_11"/>
    <dbReference type="OMA" id="TDWPLTH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307870" evidence="2">
        <location>
            <begin position="29"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="263"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="365" mass="38064" checksum="54AB9142E64F23F4" modified="2011-06-28" version="1">MAAMFFAAVTLAASAVVAVTASPDPAAAHGAAMTPGARTYLCWRDGLSPTGEIRPQNPACSAAVAQSGANSLYNWFSVLRSDAGGRTTGFIPDGQLCSGGATGFRGFDLARDDWPLTHLTAGRTMEFRYSNWAHHPGTFYFYVTKNSWSPNRALAWSDLEEQPFLTVTNPPQRGAVGTNDGHYYFTGTLPANKSGRHIIYSRWVRSDSQENFFGCSDVTFDGGNGEVTGIGNGGTNPPPTTPPPTTPPPTTPPPTTPPPTTPPPAGNGGCSATFKVTNSWSGGFQGEVEIKNTGTSPLNGWAASWTLSSGQQISQVWNATHTTSGSTVTARNVSYNGSLGANGTTSFGFLASGSSSTPTVTCSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFG9</accession>
    <name>F4FFG9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_25865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25865"/>
    <dbReference type="EnsemblBacteria" id="AEB46271">
        <property type="protein sequence ID" value="AEB46271"/>
        <property type="gene ID" value="VAB18032_25865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25865"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_11"/>
    <dbReference type="OMA" id="TMTERFN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="57"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="395"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="429"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB46271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="669" mass="71870" checksum="B1112A38B0A27C56" modified="2011-06-28" version="1">MTTPEVAVSNHMAAGGMGGWGMLRSMRSRDEISTHRLQRGVAGRIVAFAQPYRRDIVVFLLTVVIAAVIGVATPLLAGDVIDAITQGGPDGGSVVTRLALFIAGLAVADALLSLAQRWYSARIGEGIILDLRTRVYDHVQRMPLQFFTRTQTGALVSRLNNDVLGAQRAFTSTLSGVVSNVIQLLLTAAVMFTLSWQITALSLVLLPVFIIPARRVGRRLAEITRESYNLDAKMNATMTERFGVAGALLVKLFGRPDAEADRFARRAERVRDIGIQSAMYSRTFFVAMMLVASLAQALTYGLGGWLAVRGDVSAGTVVTLALLLTRLYGPLTALSNVRVDVMSALVSFDRVFEVLDLKPAITERPGAVPVPKGTGTVEFRDVRFRYPSAAEISLASLEEVATLDRTINEPVLKGVSFKVEPGQMVALVGPSGAGKSTLSMLISRIYDVTDGQVLVGGVDVRDATLASLRDEIGVVTQDSHLFHETIAENLRYAKPDATDDELWAALAGAQVADLVRSLPDGLETTVGERGYRFSGGEKQRIAIARLLLKAPSIVILDEATAHLDSESEAAVQRALSVALTGRTALVIAHRLSTVRDADQILVLDGGRIVERGRHEELVAVGGLYAELYRTQFAVADSPSPYADAAHPEPVVIPTREYVADEALPPAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFS0</accession>
    <name>F4FFS0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_02315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02315"/>
    <dbReference type="EnsemblBacteria" id="AEB47547">
        <property type="protein sequence ID" value="AEB47547"/>
        <property type="gene ID" value="VAB18032_02315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02315"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069607_0_0_11"/>
    <dbReference type="OMA" id="FLPAHWQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="32134" checksum="97F59680A28E73D2" modified="2011-06-28" version="1">MMAGSTVEPTRGGGEPTSAAGVAASGAGAGYRPSRTLPFAAEFRRQASRRRTQLALGFMVLLPLIILIAFQFDTGDDDSGRGEFGSLVSFATSGGLNFTLFTIFVSASFLLVVVVALFCGDTVASEASWGSLRYLLAIPVPRARLLTIKLLVALTYSGLALVLLAGTALLIGTLRYGWSPLRSTVAAQLEPGEGLLRLLAVLGYLAVVLLVVAGLAFLLSVITDAALGAVGGAVLLWILSSILDQITALGAIRSFLPTHYSTAWLGLLSTPVQTDDIVRGAVSAICYATAFWGLAFWRFTRKDVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFS2</accession>
    <name>F4FFS2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736182.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02325"/>
    <dbReference type="EnsemblBacteria" id="AEB47549">
        <property type="protein sequence ID" value="AEB47549"/>
        <property type="gene ID" value="VAB18032_02325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02325"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726900_0_0_11"/>
    <dbReference type="OMA" id="LRTHERW"/>
    <dbReference type="OrthoDB" id="1962787at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="390" mass="42325" checksum="DAB0AFCE44878F17" modified="2011-06-28" version="1">MTVPAPRVRRRPRTRGRLLPLLLSIALLLPVALLTVQAHRLVDADREVVERERLGVEYLRALAPVTEALVNAQSAAIARRPLPRQVLEQAIEQVAAVDARIGGELRTGERWAGIRAKLEALPERSLTDPEAAFAAYREVTDLLLALHTKVRESSGLIRDAGADSHFLQDGVGEEMPEALVAAGRLTDLATLIERRPATDQLRSFGELAAHRVAALQPANDLVNNLRAVMDSSESADLGANVLSSFDAYQRGVEAMALTSQPDQTGKLDVVRLTGARLEAQEAAKQLQPVLLDEIDRLLAERIDELNRDNLLVLGAGGVAGLLLIALAVTSWLSRPRDNPGTVDASGNEPERAGSDRPSDSHWEQMAAQRPPVPVGQGSDPDRWRPFDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG54</accession>
    <name>F4FG54_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="4" type="ordered locus">VAB18032_13430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732465.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13430"/>
    <dbReference type="EnsemblBacteria" id="AEB43798">
        <property type="protein sequence ID" value="AEB43798"/>
        <property type="gene ID" value="VAB18032_13430"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13430"/>
    <dbReference type="eggNOG" id="COG0830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049215_4_0_11"/>
    <dbReference type="OMA" id="TQYTRLF"/>
    <dbReference type="OrthoDB" id="1942614at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="228" mass="24762" checksum="D282A35F85FD51F7" modified="2011-06-28" version="1">MPSMAEALRLLQFGDSVFPVGAFSFSNGLEMAVQHGTVHDRSSLQEYVRTITRLAATGDGVGVLVGHRGAALGDLDQIRRADEAVHLRKINEEMRTMSVRMGRKLAEAANRVIGESLLKKRAGESDSLVPVTYPVALGVLFAELGVDEQGAFAAHQYGAASMVLSAAIRLLRVDHLDAQSILFAVNERVDDDYQDIRGATLDDMQGFAPHLDILAAAHQHAHVRMFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGG9</accession>
    <name>F4FGG9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_26030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734955.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26030"/>
    <dbReference type="EnsemblBacteria" id="AEB46304">
        <property type="protein sequence ID" value="AEB46304"/>
        <property type="gene ID" value="VAB18032_26030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26030"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044041_1_0_11"/>
    <dbReference type="OMA" id="LCGDDDW"/>
    <dbReference type="OrthoDB" id="665169at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="33412" checksum="3BBAE52E242C5FDD" modified="2011-06-28" version="1">MTIRVVSFGGGHGLSAALRALRRCAPELDLDITAVVTVGDDGGSSGRLRAERGGLPPGDLRQALVALAGDHPATRRSAGLFQHRFAAVATDGGRPDALAGHAVGNLVISGLMELLGDPVAALEHAGAMLGAVGRVLPMSCEPVDIEARVRGTDPDRPDEVRTVRGQHQVAVSTGRVESLRITPQAPEACPEAVAAIGAADWLIFGPGSWYTSVLPHLLVPQLAAAILASSARRLVTLNLAAEQETLGLSVADHLAALRWYLPELTVDYVIADSKAVGDPAPVDRAAESLGARLVLAPVAVDDGTPRHDPAALAAALVPVLGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGT2</accession>
    <name>F4FGT2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, ArsR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736225.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02540"/>
    <dbReference type="EnsemblBacteria" id="AEB47592">
        <property type="protein sequence ID" value="AEB47592"/>
        <property type="gene ID" value="VAB18032_02540"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02540"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063235_0_0_11"/>
    <dbReference type="OMA" id="AYNADFI"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="255"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="328" mass="35357" checksum="12B56DD6F782706D" modified="2011-06-28" version="1">MRIEVTPADVAASRYAVSPLGETVSALRLHAGQRASDGLGPWVARTRPAYERLRREVPAVGALLALLRRGGYNADFIQPPPDGTARDFHGELAAVRATPLAQARDELARNLAGPRATPPAYARRIYAAPNVVDLIADAIEESWKALVEPDWPRLRAILERDLVRRAGRLLAYGWGAAVADLDPRLRWIPGDVGVIEIDSNDPDTHSLAGRGLLFVPTVFGTLIAYVEQPWPYAIVYRASGVAELLGPPDPARPDDALDRLVGRSRAAVLRALALPATTSQLVAQLGLSLGGVGDHLTVLREAGLVSRIRTGRAVRYRRTPLGDALCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGT9</accession>
    <name>F4FGT9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_02575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736232.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02575"/>
    <dbReference type="EnsemblBacteria" id="AEB47599">
        <property type="protein sequence ID" value="AEB47599"/>
        <property type="gene ID" value="VAB18032_02575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02575"/>
    <dbReference type="eggNOG" id="ENOG502ZK6E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_1_3_11"/>
    <dbReference type="OMA" id="WARFIRA"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7483" checksum="95722C469E682C67" modified="2011-06-28" version="1">MHDLVGAVWRTSSRSNDQGLCVEVADNLARRRGVVGIRDSKDQAGPVLMVSPRGWSAFVGAIRDGDFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGX9</accession>
    <name>F4FGX9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_07345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07345"/>
    <dbReference type="EnsemblBacteria" id="AEB42593">
        <property type="protein sequence ID" value="AEB42593"/>
        <property type="gene ID" value="VAB18032_07345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07345"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="OMA" id="IPVMIMD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="179" mass="19248" checksum="A5FDF3865EEE57EA" modified="2011-06-28" version="1">MKIVLTGPLGVGKTTLVGAVSDIAPLTTEARMSAGGDDVSHRPGKVTTTVAMDFGRLAINDVTVYVFGTPGQARFWFMWDAIVRGAVGAVVLVDTRRLADSFRHLDYIENRRLPFVVAVNQFPDTHVYSPGEIRDALTLAGDVPIVEVDARDRDSVRHLLIALVEHVIATTQAPAGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGY7</accession>
    <name>F4FGY7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42601">
        <property type="protein sequence ID" value="AEB42601"/>
        <property type="gene ID" value="VAB18032_07395"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07395"/>
    <dbReference type="HOGENOM" id="CLU_2774819_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="69" mass="7870" checksum="A9C532DAB612A1DC" modified="2011-06-28" version="1">MENARNIRPIWTRRSSRCQNDHCVDVSRYPTSVQVCNSVTPDVTLSFTDGSWRTFLQALGNNTLQLPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH36</accession>
    <name>F4FH36_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional activator domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_07650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07650"/>
    <dbReference type="EnsemblBacteria" id="AEB42650">
        <property type="protein sequence ID" value="AEB42650"/>
        <property type="gene ID" value="VAB18032_07650"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07650"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013188_0_0_11"/>
    <dbReference type="OMA" id="WRIADRC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="206"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1012" mass="106297" checksum="D2BEAFE10A6AAABF" modified="2011-06-28" version="1">MSTATVAAVVLAAAPLGLLYLAGPDLIPGPPSDEQLRAWVHQPLTTGFLTALLQAAAWLLWALFATAVAHRVRQRVGARVRWRFALRLPGPLQGLAAALLGATAVTSAALPAAAHTTSTADTSPLDLPPPADTPSPTLDRNLQRPAPLPTVAASASPTDTRHAPPNSQRAADVTDDTRTAAPHRTTHTGGQPSSAARTTGKPAQADTCVVRPGDTLSAIAEQRLGDPDRWPEIWKLNRGTRFDTVGGTFTNPHLIHPGWTLRLPKEALPPTTATPLPAAPPPEADTPEPRPTTPGKSATTPVPSASADVPPGPTASTPVDDAGPATPPVPSAEGRPGRSTASGPSPSSSPEAQTSRGITVGSGSWLDVGLAAAIAAAAVLVWALRRRHYQPRSPSSARRGDADLTPLPAVVTRIRRSLRQQHNDNDIGVDILDTTNPLDATAEPVAAGDDVEDNTPAGSEPSSRERSAADAAAPVVPALDNCAAVWPAAGLGLTGPGAHAAGRGFLTAALAAGDAHDPHTRGSVVIPSPTAASLLDAAALPVSPRLTVTRSLADALDLLETLALHRTRLVYRHEVDTIADLRHRQPHTQPQPPVLLIADTAARHERVRIAALLAQGQRLDIHGILLGPWPEGDTVVVDTDGTTSPADETTRHTGHPADLGRLTVLTPADTIDLITTLTEAHTGTRHTPPTPPTDLATTSEPTRHAGADGNDHAEPGPSQAAAVDTGPETGAVDGRTRAGAPAAVDGRPEPTARPDGRVAVGTLGTARIVDMDTSVPLRAKALELLVYLVVHDGDATQDAILDDLLPDAPRSKAPHRLHTYVSALRKTLTRTGGATGNYLTHPGRRYALNRELIDADLWRMRDALRDAQRADDPDERLTALRTAVAAYQGALADGFDYEWIEAPREAIRRQALDAHLALAAATPDPAEAITVLNTAIHHDPYAESVYQHAMRAHAALGHLDEIVALRRTLTHRLHDIDTTPSRDTLTLADQLITELQASPRDRSRPDARGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHC6</accession>
    <name>F4FHC6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase group 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_13960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732571.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13960"/>
    <dbReference type="EnsemblBacteria" id="AEB43904">
        <property type="protein sequence ID" value="AEB43904"/>
        <property type="gene ID" value="VAB18032_13960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13960"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_11_2_11"/>
    <dbReference type="OMA" id="GNMGRCH"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="18"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="214"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="424" mass="46109" checksum="95B2E3EB2B4EC7DD" modified="2011-06-28" version="1">MKIVYLHQYFRTPTMAGGTRSYEFARRMVERGHQVHVITSDTGLSDAGPTGNRPGPTWRTSVEGGAVVHWARVPYDNSMRYRDRLRAFGRFAWLAARRASVLDQDVVLATSTPLSIALPAVYSARRKRVPMVLEIRDLWPEIPIALGALRSPLTRRAAWLLESWAYRNARHVIALSPGMADSISTRHPDRPVTVVPNGCDRELFADAERAGRTFRASTPWLGDRPLILYAGTLGLVNDLGYLVRMAAAMSGRHPEIRFVVVGRGGQQEHVRRLAAELGVLDRNLFMLDQVPKSEVVGLFGAADLAISTVIDDPTLHANSANKVFDAWAAGCPVALNQEGWLADRVRASGAGVILPPGDPTTGAALAASFLAEPARTAAARAAALRLAREEFDRDLLFQRLEDVLCQVVGADQSSLVGASGGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHH3</accession>
    <name>F4FHH3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_20225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733800.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20225"/>
    <dbReference type="MEROPS" id="S45.003"/>
    <dbReference type="EnsemblBacteria" id="AEB45145">
        <property type="protein sequence ID" value="AEB45145"/>
        <property type="gene ID" value="VAB18032_20225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20225"/>
    <dbReference type="eggNOG" id="COG2366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011790_2_0_11"/>
    <dbReference type="OMA" id="WAITNAM"/>
    <dbReference type="OrthoDB" id="186419at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="679" mass="73650" checksum="E35D230E1B09A0A9" modified="2011-06-28" version="1">MSKRYRDGYGIPHLRADDHEALAFAQGRVTARDRAWQIEVERHRSQGSSAAFLGPEALSWDSFARRVRLDDTARRCHAALDPATAAWVGRYVDGVNAGLAAGAARAPEFAATGLSPGRWEPWTPLAIWLGHHVLFAGFPGKLWREHVIRRLGPGAARLFAVDGHVTSGSNGWLLAGERTATGTALIAGDPHRFIEAPGIYQQIRLACPEYDVLGFAVPGVPGIAHFGHAGTVAWAITNASADYQDVYAERLRRDGDGVQAYGPQGWQPVHRHVETIEVAGADPVEVEVIETERGPVISGGSDEPPEVTVSLRYPPRVTGDLGFAVLPALLRARTVGDLDTALDDWVEPVNVVLAADTAGGLLHRVAGRVPRRHPDNGLRVVPAWEPAYAWQGWHSMPKRPVDQVAVMANERSISAGLGVEYAPPYRADRIRELLGERTDWRAEQMASVHTDTYLAAAGPLLDLLADVDGLSAPAQALRDRLLRWDRRMVADSVDAARFADLRAAVVHALAAHPALAELTAPPAHPEVFTPWLALLPRIGYALPSLLRADLPGLDPAELVRTAAEQVAAADDTRRWGERHRLAAWRALPDPAAAPGPELAGDHDCVLATSSIPGVTDLCGRGPSARYVWDLGRRENSRWVVPLGATGAGPHHDDQLPLWVRGDLIEVTGDWDRLTEEHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHY2</accession>
    <name>F4FHY2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736307.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02955"/>
    <dbReference type="EnsemblBacteria" id="AEB47675">
        <property type="protein sequence ID" value="AEB47675"/>
        <property type="gene ID" value="VAB18032_02955"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02955"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_18_2_11"/>
    <dbReference type="OMA" id="GWAGATM"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="211" mass="22777" checksum="D9953ACF79A8D557" modified="2011-06-28" version="1">MSTASTRVPQQERSRATQARLLEATLDCLVEHGWSGTTTTVVAQRAGVSRGAQLHHYPTRAALVTAAVVHLTERRAAELRGEAETLPTGPDRLDRVVDLLAAAFTGPLFVAALELWVAARTDAELRAALLPLEARVGREMYRLTVELLGVDERRPGVREAVQATLDLLRGLGVANLLSDDSARRTALLHAWKHQLAALLTPAADPPGSARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHZ6</accession>
    <name>F4FHZ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736321.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03025"/>
    <dbReference type="EnsemblBacteria" id="AEB47689">
        <property type="protein sequence ID" value="AEB47689"/>
        <property type="gene ID" value="VAB18032_03025"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03025"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091241_0_0_11"/>
    <dbReference type="OMA" id="TGWWVCE"/>
    <dbReference type="OrthoDB" id="1875094at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="20674" checksum="654963A935CAF8B2" modified="2011-06-28" version="1">MTQPPTSGPTGPTELPPPPPTSPPPPGYPPPGYPPTGYPPHAAPAGRPPRKRGALLAALALAVVLVLCAGGGVAAFLTVRNAESGEGAPEPSVAVDEFLTAIYQERDAAKASRLVCSSARDQQKIRAKVAEVEEYLSAHQSPRFRWDTPKVDNETGDRATVTTTVTVTTADEKIANQDLRFTVIRKTGWWVCEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI08</accession>
    <name>F4FI08_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative biotin carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736333.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03085"/>
    <dbReference type="EnsemblBacteria" id="AEB47701">
        <property type="protein sequence ID" value="AEB47701"/>
        <property type="gene ID" value="VAB18032_03085"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03085"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_4_0_11"/>
    <dbReference type="OMA" id="YHRGIDH"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="115"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="411" mass="44601" checksum="75FC1D3C532116BA" modified="2011-06-28" version="1">MKPHILIIHRWRDHHAGYADYLDHDLHHVTYICTELATASVPAAASAVSIVAATDRLDLVSAAADGLIERFGRPERIIALNEGDLDTAAELRAHLAVAGDHPDQLAPFRDKLVMAQTVVAGGVAIPEFADAPDTEAVVRFADLHGWPVIVKPRRGTASRDVLRLNSVDDLVQLDRLAPEPRMVQTFCPDQVFHIDGLWTGSELGAWRASRYVNTCMEFAAGDVLGSVEVDDPELLGPLGEFLARACAAFGDEPWVFHMEAFVGHRADGSIRINFLEAGSRVGGAEIPFVWREVHGVDLVEAAVHIQLGRRPIVRSISGQRVGGWLLVPTPVPAPCRITVAELDLPPAEWPYARVIPDVGTVIPKAGGYEHVGARFRFSGAATDDVEKAIRRTAGQLWLECVPSQSDLPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI18</accession>
    <name>F4FI18_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_03135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736343.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03135"/>
    <dbReference type="EnsemblBacteria" id="AEB47711">
        <property type="protein sequence ID" value="AEB47711"/>
        <property type="gene ID" value="VAB18032_03135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03135"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="OMA" id="ERKFDGH"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="25890" checksum="9435BA3E4BA8B2A4" modified="2011-06-28" version="1">MKRTAVVTGASSGIGAATARRLAKDGFFVVVAARRLDRLQALAAEIGGQAVALDVTDQASAQALAAGLERCDVLVNNAGGAVGADPLASASPADLMQSFEVNVLGMLHVTQALLPLLRSSDAPTIVTVTSTAAHVNYEFGGTYTAAKHAEHALVETLRLELCGEPIRVVEIAPGMVRTDEFAVNRFKGDADKAAAVYAGVDRPLVAEDIAECIALTVGLPSHVNVDRLVVRPVAQAAQHKVHRQPLFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F118</accession>
    <name>F4F118_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07760"/>
    <dbReference type="EnsemblBacteria" id="AEB42672">
        <property type="protein sequence ID" value="AEB42672"/>
        <property type="gene ID" value="VAB18032_07760"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07760"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_11"/>
    <dbReference type="OMA" id="PHPPEFR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="103" mass="11838" checksum="24B529DD54101205" modified="2011-06-28" version="1">MENVGKKRSRPRRAFTPDFKAEIVELCQRGDRTVGQVARDFDLTETAVRAWVKQAELDAGTRSDGLTSDERTELARLRAENQRLQQDVDILKRATAFFARETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F186</accession>
    <name>F4F186_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, lysr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14050"/>
    <dbReference type="EnsemblBacteria" id="AEB43922">
        <property type="protein sequence ID" value="AEB43922"/>
        <property type="gene ID" value="VAB18032_14050"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14050"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OMA" id="GKQPELC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="29343" checksum="0049D52D4EAF8E8F" modified="2011-06-28" version="1">MEDTLGAPLFERVRGNITLTAAGEVLLPLAKRILADVETATREVQELVGLRRGRVRLGATPSLATSLAPPVLRRFRDVHPTVDLRVEEGGSQDLVRHLLRGDLDLALIIMPAQGIDPGLRADPILTESLVVASVDPLPTAYPGADLQITDLRDQPLVMFREGYDLRDATLQACRAAGFEPTLSVDGGEMDAVLSFVEAGLGIALVPGIVVARRPGIRVTRLAPPGVRRTIAVARRRDVVPTHAGRELRRILLDYVHTATADDELPPGVEPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1C7</accession>
    <name>F4F1C7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucanase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_14255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14255"/>
    <dbReference type="EnsemblBacteria" id="AEB43963">
        <property type="protein sequence ID" value="AEB43963"/>
        <property type="gene ID" value="VAB18032_14255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14255"/>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015488_2_1_11"/>
    <dbReference type="OMA" id="SNVSNFH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005129474" description="Glucanase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="9">
        <location>
            <begin position="350"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="457" mass="46528" checksum="FCF1211E3D5EF5F6" modified="2011-06-28" version="1">MRTRRTSAVVGAVTALTVAATVGVGALLAAPAAAADSAFYVDPQTSAARWVAANPGDSRAAVIRDRIANVPQPRWYTTTNTSTVQGEVSQFVGAAAAAGKIPILVVYNIPNRDCSNHSGGGAPNHSAYRQWVDQVAAGLQGRPATIILEPDVLPIMTSCMDGNQQAEVRASMAYAGKALKRGSSAAKVYYDIGHGGWLSAGEAANRLLAADIANSADGISVNVSNYRSTAGEVSYAKSIIAATGISRLKAVIDTSRNGNGPAGSEWCDPPGRAIGTPSTTNTGDSAIDAFLWVKLPGEADGCIAAAGQFVPQRAYDLAIAAGPLPTTPAPTTPGPTTPPPPTTPPPPSTPPPGGAGCTVTFTPNTWTGGFTAEIRVTNRGSSVNGWTLAFTAGSGVRLSNGWNGVWSQSGDRISVRNADWNGSLPSGGTLSTGFQGTYSGSSLPAPSGFTLNGTNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1E1</accession>
    <name>F4F1E1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732644.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14325"/>
    <dbReference type="EnsemblBacteria" id="AEB43977">
        <property type="protein sequence ID" value="AEB43977"/>
        <property type="gene ID" value="VAB18032_14325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14325"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124276_0_0_11"/>
    <dbReference type="OMA" id="WPLVIND"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="148" mass="16663" checksum="B2ADCFEB05C4B749" modified="2011-06-28" version="1">MAIVQQVIKAPVQQVWAVLADGWTYSDWVVGTAHMRNVDDGWPAVGTRLHHRAGPWPFSLEDSSLVLECEPERKLVLRVKLWPAGEAIVVFALEPVGPDATRVSLGEDFAAGPLRWVRNKLNDLVLHQRNKETLNRLSDIARRQKTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1J1</accession>
    <name>F4F1J1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733874.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20600"/>
    <dbReference type="EnsemblBacteria" id="AEB45220">
        <property type="protein sequence ID" value="AEB45220"/>
        <property type="gene ID" value="VAB18032_20600"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20600"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OMA" id="ITAPAMP"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="243" mass="24722" checksum="DF319F3C599CC818" modified="2011-06-28" version="1">MTAPVTVITGGSRGIGAATARRLAAAGHHLALGYRRDHATAEAVATELRATGVRVVVVPADTRDPDQVSALFDAAAALGPVTGLVNNAGITSPIGPFTDLRVDDLREVVDVNLVGYVLCAQQAAHRMTDGAAIVNISSVAATLGSPGEYVHYAAVKAATDALTIGLAKELAPRGIRVNAVAPGIIRTDIHALSGQPDRPDRAAARIPLGRPGEPDEVAAAVAWLLSPDASYTTGAVLRVGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1N8</accession>
    <name>F4F1N8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735114.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26951"/>
    <dbReference type="EnsemblBacteria" id="AEB46463">
        <property type="protein sequence ID" value="AEB46463"/>
        <property type="gene ID" value="VAB18032_26951"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26951"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_0_0_11"/>
    <dbReference type="OMA" id="GWLGKPH"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="375" mass="40071" checksum="1BD27DEB52FABF75" modified="2011-06-28" version="1">MTGPLVVLLVVVALTAHTLVNAGRWLRRPADRPVQTDERVSVLLPLRDEADRVTPCLRALLAQRGVPGLRIVVLDDGSTDGTAEVVRAVVGDDPRVTLRTGVAPPPGWLGKPYACWQLASRVETSADALVFVDADVVLGPYAVAAAVTELRAAGAELLSPYPKIVVRTVTDRLVQPLLQWLWLTFLPLRAMERSQRPSLAAAGGQFLVVDRVGYLRAGGHAAVADRVLEDIELARAVKRAGGRIALADGSRLASCRMYDSWPQLRDGYTKSLWATFGHPLAAALVVGLLLLLYTAPPLVAVAALLAGAPALAGVAALTYLAGVVGRVVSARATGGRAWPDALSHPVSVAVLGWLTLRSYHLRKRRRLSWRGRPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1V5</accession>
    <name>F4F1V5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_27286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735180.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27286"/>
    <dbReference type="EnsemblBacteria" id="AEB46530">
        <property type="protein sequence ID" value="AEB46530"/>
        <property type="gene ID" value="VAB18032_27286"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27286"/>
    <dbReference type="eggNOG" id="COG1929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028255_0_0_11"/>
    <dbReference type="OMA" id="CRFEVAC"/>
    <dbReference type="OrthoDB" id="1292731at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="379" mass="37825" checksum="F42022D4A3984B83" modified="2011-06-28" version="1">MRVLLCPDKFAGTLSAPQVAAAVADGWREIAPDDDLLVRPLADGGPGFVDVLAAALPGRRIPVATVDPLGRPVPGEILLTDDGATAWLESAQACGLHLLDAGERDPRTTTSYGLGLLITAAVEAGARTVVVGLGGSATNDGGAGMLAALGAVALDDTGTALPYGGAALTAVATLDGAPRLRDVRLIAATDVDNPLLGLHGASNVFGPQKGADRADVLLLDAALQRWAEVLQQQVPGCPSGLGALPGGGAAGGIGAALLALGGRCESGIGLVSRAVGLNAALDGVDLVITGEGKFDHQSLRGKVVAGVAGAARDQGVPCVVLAGQVSTGRREAASVGVTEAYSLVEHFGGEERGGLSAALERPGEGLRALGARLARQWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Y5</accession>
    <name>F4F1Y5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA polymerase III, subunits gamma and tau</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_03240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736364.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03240"/>
    <dbReference type="EnsemblBacteria" id="AEB47732">
        <property type="protein sequence ID" value="AEB47732"/>
        <property type="gene ID" value="VAB18032_03240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03240"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_3_2_11"/>
    <dbReference type="OMA" id="WALVEPN"/>
    <dbReference type="OrthoDB" id="556582at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="36"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="729"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="966" mass="97226" checksum="A92A727AB2D25432" modified="2011-06-28" version="1">MALALYRKYRPRTFAEVIGQEHVTEPLSQALRSGRLNHAYLFSGPRGCGKTSSARILARSLNCEHGPTPEPCGVCASCRSLGSDGAGSIDVIEIDAASHGGVDDARELREKAFFAPASSRFKIYVIDEAHMVSSAGFNALLKLVEEPPEYVKFIFATTEPEKVLGTIKSRTHHYPFRLIPPKVLRPYLEQLCQAEGVEVEPAVFPLVVRAGGGSARDSLSVLDQLIAGAGPDGVTYARAAALLGVTDAALIDEMCDALAAGDGAAAYATVDRVAEAGHDPRRFASDLLERLRDLIVLQQVPDAAAKGLIDGPADQIERMTAQAQRLGPATLSRCADIVHNGLVDMRGTTAPRLLLELICARMLLPAADDSTGGLLQRLERMERRLTLAGTDALPAAADSAPTTTPAVRPQPPAPPAAGAASAARTAGEPAAPGTPSGVAAARAAAANAGTRAQAAGGPGTRGSAASDADAHQPSAGAPAADDGSDHGVNREATRAPNPNGAGPGPTGGHAGDTASSGVPADAPPSRRPVPPSAVMPDPVTPEPPRPGAVQPGVLDAAAVRRIWPEVVGKVGRKSKKVAAWAREATVREVDGQTLVLTFRYPFHAQALSNEPELLIEALYEELGGRWQIRCEVAGERGGGAPVGPRAASAPPRPAPAPADSRAGTGPSAGSSSAEHGAPGRPGGGTGPATGSASAAGAAGPADVAYSARAAGSPGATNSVGAAGLPGATTSAGAASSAGARNSAGATSSAGAGSSAGVASSVGVAEAVDDEGWPEPARPGGSAPVVSAATDVVDEWPEPARPGGGGDQTAPSARGASAGTTATARAATETVSPSGASTSGNTKATPASSTRAVPPGSTRAAPASSAIAAARAAAAGRGARTDQATRQTADAEFAGEPPYDPDFDGPIRSTGAQPAPTAAYEGFDPGDEPLDEIIDEKTARESSEEQALRLLREAFATTEKISEPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Z9</accession>
    <name>F4F1Z9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_03310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="263358.VAB18032_03310"/>
    <dbReference type="EnsemblBacteria" id="AEB47746">
        <property type="protein sequence ID" value="AEB47746"/>
        <property type="gene ID" value="VAB18032_03310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03310"/>
    <dbReference type="eggNOG" id="COG5555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496898_0_0_11"/>
    <dbReference type="OMA" id="DRNSDFN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="545" mass="54583" checksum="11A2A7E584297338" modified="2011-06-28" version="1">MAIGAGLAVSVPAPAAANDYRTVTRDGIVLQHYRVAKATTPVKGTGPTRSDFDGDGIDDIAASADPFEHRFPQSPMGLVVVRYSSAPYVDHFATGVTPAGGCVCFGEVLAAGDFNGDGYDDLAAADLGEYDLSAKANAGGVWVIPGSSTGLRIDAAKHFNQSSPGVPGASEEGDWFGSALAAGDINGDGRDDLAIGAYGEAIGSITYAGAVTVLYGGASGLTGTGAQQLHQNQAAVPGSAERNDHFGWTLAIGKVNDNKYADLVIGAPGENENSSSTGSGMLTLMWGSANGVKLSGATSVTGAALRKATGRTDSYVRSLGMALAIGDVNGDKLGEVIAGAPYTQSPKGNEGMVAVFTGRSGGAGLSSSAVKMFSQRTPGVPGSAEVGDLFGATLAVGDVTGDGRADVLVGAPGEAIGTKKRAGTVALLKGSASGLTGTGAQGFDQDHPVVPGGAESNDLFGGAVAILNLDGRGPLDAVVTSPGELVGADPERPASGSVALFHGGSGGLVPQTASWSGASMRTDFVWPKWYGRRLATAQSGALMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F245</accession>
    <name>F4F245_MICM1</name>
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        <submittedName>
            <fullName evidence="3">Transcriptional regulator, paax family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731407.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08080"/>
    <dbReference type="EnsemblBacteria" id="AEB42734">
        <property type="protein sequence ID" value="AEB42734"/>
        <property type="gene ID" value="VAB18032_08080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08080"/>
    <dbReference type="eggNOG" id="COG3327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067515_2_0_11"/>
    <dbReference type="OMA" id="YGDHLRP"/>
    <dbReference type="OrthoDB" id="1210594at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="165"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="30579" checksum="EE4F8F33E8190F7B" modified="2011-06-28" version="1">MQARSALFDLYGDHLRPRGGRAPVAALVKLLAPLGIAPPAVRTAVSRMVRQGWLEPVKLMSGPGYSITPKAGRRLDDAASRIYRTGRVTWDGRFDLLVLDAPSARRDRQRLAANLRYLGYGTLDEQVWVATRPGEDVDLMLDEAGVRFERFSAAHAAGTPGAMGLVRRAWDLAEIGRAYEQFVAEQRALLSGITARSGDEEAYAARFRLVHAWRTFLFRDPQLPPALLPERWPGTAAASFFDRHAARLRPAADRYVEQCLDGGNRMIRQKERQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F4F262</accession>
    <name>F4F262_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB42751">
        <property type="protein sequence ID" value="AEB42751"/>
        <property type="gene ID" value="VAB18032_08165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08165"/>
    <dbReference type="HOGENOM" id="CLU_3223541_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="44" mass="5123" checksum="182A0EA3C4A10BC5" modified="2011-06-28" version="1">MRRLARLLVRRLPVRRLTRVRLAGLSVLRLPGLAGWPVLRLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F278</accession>
    <name>F4F278_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731438.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08245"/>
    <dbReference type="EnsemblBacteria" id="AEB42767">
        <property type="protein sequence ID" value="AEB42767"/>
        <property type="gene ID" value="VAB18032_08245"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08245"/>
    <dbReference type="eggNOG" id="ENOG5032TXC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112849_0_0_11"/>
    <dbReference type="OMA" id="YVALPRF"/>
    <dbReference type="OrthoDB" id="2023054at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="161" mass="17406" checksum="02F5D3A4EADE1D3B" modified="2011-06-28" version="1">MFEKALGLPLHVLVVHAVVVFVPLLVLLALAYVALPRFRARLDWAVAALAVVAPITAWVSVQSGEALQERQIARGFSGEILDKINEHAEYGDVLFWITLGLAVAVVLLLVATGRHDRLPKLPNWAAPVLSVLVLGLGVAALVYVWLTGHSGAEMVWGNTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F298</accession>
    <name>F4F298_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_08345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08345"/>
    <dbReference type="EnsemblBacteria" id="AEB42787">
        <property type="protein sequence ID" value="AEB42787"/>
        <property type="gene ID" value="VAB18032_08345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08345"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_1_1_11"/>
    <dbReference type="OMA" id="IFELHTP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="383" mass="41741" checksum="89057BEA2A1F99B1" modified="2011-06-28" version="1">MLERGEIANSWRHERWDSLRLLTPNWLNRLPGHRYQGPDPDGYLTMGEVVEFIEQYAAVSAAPVRTGTNVESLRRDGDGYLLATSRGDLRCQAVVLASGACNVPTVPAISAQVPTTVAQLTPFDYRGPDQVAEGGVLVVGGSATGVQLAAELQRSGRQVILATGEHVRLPRVYRGRDVLWWMDASGVWDQRYDEVDDLTRARRLPSPQLVGTPERSTLDLNALTALGVELVGRLAAVRDGTALFSGGLRNVCSLADLKMRRLLAGFDEWARTTGHDAEVGPPEEFAPTAVAASTRLRLDLRGGEVGTIVWATGFRPDYRWLDVPVVDEKGRLRHEGGVLDSPGLYALGLPLLRRRRSTFISGIEDDACAVVDHLAKNLPAPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2D1</accession>
    <name>F4F2D1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732670.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14455"/>
    <dbReference type="EnsemblBacteria" id="AEB44003">
        <property type="protein sequence ID" value="AEB44003"/>
        <property type="gene ID" value="VAB18032_14455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14455"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_11"/>
    <dbReference type="OMA" id="RAWNDRS"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="327" mass="35195" checksum="7A29E6D212C2D8BF" modified="2011-06-28" version="1">MEQRTFPRLGRQAGVVGLGAWQLGADWGTVSEDDAMAVLDAAVEAGVTFLDTADVYGDGRSEQLIGRFRAARPDTALTVATKMGRRVPQTPEAYTLDNFRAWTDRSRANLGVDTLDLVQLHCPPTVVFADDAVFDALDTLVEEKRIAAYGVSVETCDEALTAIARPGVASVQIILNALRHKPLERVLPAAANAGVGIIARVPLASGLLSGRYDEHTTFAADDHRSYNRHGEAFDVGETFSGVDFTTGLAAVRRLAPLVGDDRTMAQFALRWVLDQPGVTVVIPGARDAAQARANVAAADQPPLSTSELAEVASVYDELIRPQVHHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2G6</accession>
    <name>F4F2G6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_14630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732705.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14630"/>
    <dbReference type="EnsemblBacteria" id="AEB44038">
        <property type="protein sequence ID" value="AEB44038"/>
        <property type="gene ID" value="VAB18032_14630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14630"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024494_0_0_11"/>
    <dbReference type="OMA" id="DCPMPPL"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="102"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB44038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="668" mass="70512" checksum="5D23C7C79EC7CA1E" modified="2011-06-28" version="1">MNFFERQRQVRRLSTRLVLLFVLAVIGIVVVVNVAAIFAFNATAADPGQLAGFVAMVTVATVAAIGLAALVRTLALRGGGGKVARELGGVPVPPDTTDPELRRLRNVVEEMALASGVPVPEVYILPEETAINAFAAGWGPSDAAVAVTRGALQRLNRDELQGVIAHEFAHVVNGDMRLNIRLMGLLFGILFLTVIGRGLSRSGLISGGNRQRGNSGGGVNPLLLVGLALLVAGYVGVLAGRLIQASVSRQREYLADASAVQYTRQTRGIAGALKKIGGLADGSELKSPKRDEVGHMLFGEAARTSWFATHPPLADRIRALEPSFDPAELQRLSRQWAAAPPSGRQEDVALGLAPAAPPQPAPGQVPTDRAAGAEAAGGVRPEASPLPVPGTRVRLAPTEVLGRVAAPTENAYQHAAALLDQIPAPLLDRARGRDTAVPLLLGLLISAEPQVRQHQHAALAQQHGRELADAALGQAQALTGLHPMLVLPLAELTFPALRDRPAPELESTVAAVFTLIHADGAINVSEYCLSRLMLAEIQESLRPDSRWRTDRRTLTDARSAAGFLLATLAQVGHAERADAQRAFQAGVDLLLPGTTWSYAPPENGVLALETAWPVLDGLRPADKERLVAAVVAVISHDQMMTVAEIELLRTICGLLHCPLPPMVGAGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2S8</accession>
    <name>F4F2S8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_21215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21215"/>
    <dbReference type="EnsemblBacteria" id="AEB45343">
        <property type="protein sequence ID" value="AEB45343"/>
        <property type="gene ID" value="VAB18032_21215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21215"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_4_11"/>
    <dbReference type="OMA" id="CANRMLD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="28766" checksum="F0190D2E5CA48048" modified="2011-06-28" version="1">MIRDVIVPSPGVAPAQAAPAEAGLHGRVLDHLGTAICGGELAAGAVLNIDELVDRYAVSRSVIREVLRVLASMGFIETRRRVGVMIRSADHWNVFDPQVIRWRLASAGRIAQIRSITELRTAIEPHAAWLAAQRVDHDDASELVGLAAKMWAAGKAGDEERFLRLDIEFHQRVLRASGNEMFVKLQDLVAEVLIGRHHYHLMPHYPHEQALQLHAEVAQGIQRHDGDSARRAMVQIMEHAFEEMSSIWEQTLHDPHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F326</accession>
    <name>F4F326_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_03615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03615"/>
    <dbReference type="EnsemblBacteria" id="AEB47805">
        <property type="protein sequence ID" value="AEB47805"/>
        <property type="gene ID" value="VAB18032_03615"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03615"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422068_0_0_11"/>
    <dbReference type="OMA" id="WSIGARR"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="3">
        <location>
            <begin position="57"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="182"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="649" mass="69811" checksum="0C6977202B33189D" modified="2011-06-28" version="1">MTDQKLPWSIGARRAKIVAIGAAALLAGGVALSPAAFGDATPAKFPAAEIHKPSPVPDRIMLTPTATPSTSQRVTWRAEATAEWARAELLEAPRALVGGVPASGSAVTRLAALSSTPVNTSLGYASTYHTVEFTGLKPDTRYTYRVGDGTNWSEWIDFTTAASDFEPFSFIYYGDAQNNIDSAVPRVFRQAFAERPEAKMIVNAGDLIDNANSEEQWGQWYKASGFIDGQINNISVPGNHEYSGGLSQFWRPQFPYPDNGPGNPELKQTVYYVDYQGVRFIALDSNHQSNSTLMAAQTAWLEGVLRDNPNKWTVVTFHHPVYSTTGTRNNPQVRAQWGPLFERYGVDLVLQGHDHSYGRGNVATNRRSAAVHEGTVYAVSVSGGKMYALNNGQNWTGNGAEVTSTSQNTQLYQLIDVSQGTLRYEARYANGEHHDGFLIRKNDEGERTVNELRTPSNTTGQHVTVDRTSVAVKGEVKVSAYGYDPAEKVAVSLRKLGNTPGQAEIPVANLTADQLGRISYQLAIPASAKAGGTYEVFLSSANQQITSPAITLNGWRADVQARAHCVGANAYVSVTLRNGEGEPLSVEMVTPYGSRTIAGVAGGKSASQAFNSRAKSVPAGVATVDVTGMVDGDPVTMRVEAAYEAASCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3B8</accession>
    <name>F4F3B8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_08620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731513.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08620"/>
    <dbReference type="EnsemblBacteria" id="AEB42842">
        <property type="protein sequence ID" value="AEB42842"/>
        <property type="gene ID" value="VAB18032_08620"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08620"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_0_11"/>
    <dbReference type="OMA" id="MIFGNWM"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="426" mass="44623" checksum="E4BD96075953DB5E" modified="2011-06-28" version="1">MSTMAVPDVAVAAVDEGYWTRTRKVGLVLLALGLLATVLFGALATGEQARFTLSEDAAGAALEINGTVGAVLFGLITLAAGAAMLARLPKRWFIPVLAVGLVAFVLSFLCWQVSAAPTGQNFMPLVNIVRGTFLLALPLIFGSLAGVLCERSGVVNVAIEGQLLMGAFSGALFGSISGSVWVGLVAAAIGGSFISLLLAVFSIKYLVDQVVMGIVLNLLALGITGFLYERLMQTDAARYNSAPRFSNWEIPLLSDIPVLGPALFRGNIFLYLALVLVLVIHIALFRTRWGLRTRSVGEHPTAADTLGVKVLGLRYRNVIMAGAIAGIGGASYTLALFSFTKNMIGGKGFIALAALIFGRWSPTGALLAALFFGFADQLATYLGAINSVIPGQFLAMLPYLATILAVAGLVGRVRAPAADGKPYIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3D8</accession>
    <name>F4F3D8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillinase repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_08720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08720"/>
    <dbReference type="EnsemblBacteria" id="AEB42862">
        <property type="protein sequence ID" value="AEB42862"/>
        <property type="gene ID" value="VAB18032_08720"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08720"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_1_0_11"/>
    <dbReference type="OMA" id="ESRAWIY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="19035" checksum="6D2762081E30415D" modified="2011-06-28" version="1">MTRLGDLERAVMDVLWDTVPARSDGVTVREVADALAGRELAYTTVMTVLDRLAGKGMVQREREGRAWRYRAAASREAHIAQLMLDALDLGGSRDAALVRFARSVTGTEADVLRAALAAEATLTPGTNGAEVTGVAEGTGVTNSTAGTADAGAEGVGSLTDRIEVPPADRASRPDRAGETAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3F8</accession>
    <name>F4F3F8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731553.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08820"/>
    <dbReference type="EnsemblBacteria" id="AEB42882">
        <property type="protein sequence ID" value="AEB42882"/>
        <property type="gene ID" value="VAB18032_08820"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08820"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_8_11"/>
    <dbReference type="OMA" id="HDGLTHR"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="155" mass="16851" checksum="4D3B8440B9252131" modified="2011-06-28" version="1">MKLVQLGDVPLGRLLVVAGHLTGQRWNRYLADEHGLTQAGMVTLMALAEHGELPHRAVAELCFVRPATLTGIVDTLERDGLVQRRRDGADRRSIKLTLTPDGRDRVDALTAMIRARRPLTSVDADPAKAAVIRQFLLEVIGQDESAGKPEGGPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3N5</accession>
    <name>F4F3N5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ordered locus">VAB18032_15155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732808.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15155"/>
    <dbReference type="EnsemblBacteria" id="AEB44143">
        <property type="protein sequence ID" value="AEB44143"/>
        <property type="gene ID" value="VAB18032_15155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15155"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_1_2_11"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="OrthoDB" id="1760144at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="78"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="23992" checksum="DDFA49C9FE868A96" modified="2011-06-28" version="1">MNEQIRAREVRLVGPEGEQVGIVPLERALQLAADVDLDLVEVAPMARPPVCKLMDFGKFKYESALKAREARRNQQQTVIKEMKLRPKIDPHDYETKKGHVVRFLKAGDKVKVTIMFRGREQSRPELGYRLLRRLESEITELGYVESAPKQDGRNMIMVLAPHRAVKASAVAATASRGGPRERTAEDSAAATEPAAATESVTAGESAAAGETGGTADTSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3W2</accession>
    <name>F4F3W2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21565"/>
    <dbReference type="EnsemblBacteria" id="AEB45413">
        <property type="protein sequence ID" value="AEB45413"/>
        <property type="gene ID" value="VAB18032_21565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21565"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_0_11"/>
    <dbReference type="OMA" id="ANHAIVD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="307"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="407" mass="44453" checksum="F0CE6765F8B3A022" modified="2011-06-28" version="1">MAIAGAGLSGLCLAQYLMRAGIDVHVYERDPGPFVRQQGYRIILDQYGLEALRTSLPRPLYHLALATGDEPGGQLRFTDRRLRDAFTITFKDKTHATRQVDRLTLRSILQSGLDGRIHYGKAAAGVDSSDPARLRLVFSDGGSVPASVIVGADGVGSALRAQIMPDAAPANTPMAGIYGRTPLRRNGESIIPEPLRTSGVLAIDDRPGRAFFFTSMRFGENPREAFARLAPGSYAPTGDDYVMWGLLLRQEEVPTTIRRNLLALQDLASHMSMVFHPLVRRLVDNAELDAMVLNLFATGQRPHRWALPRATMMGDAVHVMPPFGAHGGNTALRDAALLGRRLVEARASGAPVERAIARYQDEMVPYAFRAVDTAAALMRRLTGGATAPHWVLTRVLPRLHRVTVPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4F419</accession>
    <name>F4F419_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_27961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735315.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27961"/>
    <dbReference type="EnsemblBacteria" id="AEB46665">
        <property type="protein sequence ID" value="AEB46665"/>
        <property type="gene ID" value="VAB18032_27961"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27961"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="YAEHPRT"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB46665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="33672" checksum="5A94AA6D4B104F09" modified="2011-06-28" version="1">MSPVVTVTDLTKRYGDVTALDRVSFTLAENRIYGLLGRNGAGKTTLMQLLTAQIFATSGEISVFGEHPYENERVLSRISFIKESQTYPSNLRVKHALRAAALVYPNWDEEYAQQLVEDLRLPRERNVRKLSRGMLSALGIVIGLAARTPLTFFDEPYLGLDAVARQIFYDRLLADFTEQPRTIVLSTHLIDEVSDLIEHVLLIDQGRLLLDSETDALRGQVVTASGPVAAVDEFVRSGTELHRVRLGGTARATVRGDFGAAEHERARALGVDLVASSLQDIVVRLTTSSNGPAADAGSAVAADKEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F467</accession>
    <name>F4F467_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_03990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736512.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03990"/>
    <dbReference type="EnsemblBacteria" id="AEB47880">
        <property type="protein sequence ID" value="AEB47880"/>
        <property type="gene ID" value="VAB18032_03990"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03990"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="SFYKKDC"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="254" mass="27036" checksum="982A412FCF058C53" modified="2011-06-28" version="1">MTGEYPALALRGLAKRFDSKVAVAGVNLDVPAGSFYGLLGPNGAGKTTTLSMAVGLLRPDAGSAWVLGRDVWADPVEAKRLFGVMPDGVRLFDRLSGAELLAYHGLLRGMDPAVVDQRAAELIDVLALSDAGRTLVVDYSAGMKKKIGLACALLHGPRLLVLDEPFEAVDPVSAALIRDILQRYVTGGGTVIFSSHVMEVVQRLCSHVAILAEGTIKRVGTLEEVRGERSLEEVFVEVVGGRTATGEELSWLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4B1</accession>
    <name>F4F4B1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_04210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736556.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04210"/>
    <dbReference type="EnsemblBacteria" id="AEB47924">
        <property type="protein sequence ID" value="AEB47924"/>
        <property type="gene ID" value="VAB18032_04210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04210"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058580_0_0_11"/>
    <dbReference type="OMA" id="GWGTGKI"/>
    <dbReference type="OrthoDB" id="1080661at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="173"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="413" mass="44313" checksum="AC6FE184044E6ADB" modified="2011-06-28" version="1">MDPVRNPYAPGAGQRPPELAGRGRELDVFDIVLERIARGRPERSLMLTGLRGVGKTVLLNTLRSQAINRLWGSGKIEARPDQSLRRPIAAALHMAVRELAPRHRAPDRIDAFLGVLKAFAQRGAPTGRGGAAPKLRDRWQPGIDVPAASGRADSGDIEIDLVELLTDAASVASDVGTGVAIFIDEMQDLGPEEVSALCAACHELSQLGAPLIVVGAGLPHLPAVLSAAKSYSERLFRYQRIDRLDRIAADQALCAPAEREDVEYEAKALDLLYEKSGGYPYFVQAYGKATWDHAPRSPITAADVRVAAPEAEAELAVGFFGSRFERATPAEREYMRAMAALSLVEGAADGGGRDDMDAAVPTAEIARALGRKPASLSPARDALIKKGLIYSGERGTVAFTVPHFGRYLRTQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4P8</accession>
    <name>F4F4P8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732855.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15390"/>
    <dbReference type="EnsemblBacteria" id="AEB44190">
        <property type="protein sequence ID" value="AEB44190"/>
        <property type="gene ID" value="VAB18032_15390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15390"/>
    <dbReference type="eggNOG" id="ENOG5032TBA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072020_0_1_11"/>
    <dbReference type="OMA" id="FRYHIVS"/>
    <dbReference type="OrthoDB" id="1520742at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021522">
        <property type="entry name" value="MctB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11382">
        <property type="entry name" value="MctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307418" evidence="2">
        <location>
            <begin position="37"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="313" mass="32787" checksum="17F16519DFAEF986" modified="2011-06-28" version="1">MINFRYHVVSLTAVFLALAIGLVVGTAALNGPVADSLKEHVDALSKANQQMRQTVQSMERELELEEQFAAEMAQITLPGKLTGKRVLVLTTPTGRDHAEGVIKMLQLAGADLTGRIDLQDKFINPENNNNLLELAVTAARPTGAPTANLPGNGHGVETSSALLATVLLDQPAGSEPVTEADRRAVLAAYSNASYLSAADRITTAAEAVVVVSGLPYVDKDSAKKDESVVKIAEQFDRTGGIVVAGNGSANGNLVAFVRGDAVLAQTISTIDNANTVQGQLVTTLALVQQLTERKAGQYGVGDNAASLLPKLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4X6</accession>
    <name>F4F4X6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_21825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21825"/>
    <dbReference type="EnsemblBacteria" id="AEB45465">
        <property type="protein sequence ID" value="AEB45465"/>
        <property type="gene ID" value="VAB18032_21825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21825"/>
    <dbReference type="eggNOG" id="COG3483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089297_0_0_11"/>
    <dbReference type="OMA" id="DFQAMQP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="208" mass="22825" checksum="C388E49105C8AA68" modified="2011-06-28" version="1">MRIDALLGLQRSPDEVIHRDELLFQVVHQSTELWLKLAAAELAEATAQVAAGRLAAAEAFLVRATLAVRLITDQLEMLRYLSPVDFQAMQPALGNGSGAESPGWRDVQGASRKLGRAFDEQLATRGITATALCPTDPAEPLHRLAEAMVEWDERVSVWRVRHYQVALRIGGHRPAGSPGSAANMLAKLAGHRFFPELWQARTSLTTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F503</accession>
    <name>F4F503_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_21960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734145.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21960"/>
    <dbReference type="EnsemblBacteria" id="AEB45492">
        <property type="protein sequence ID" value="AEB45492"/>
        <property type="gene ID" value="VAB18032_21960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21960"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066229_0_0_11"/>
    <dbReference type="OMA" id="LIWRQHR"/>
    <dbReference type="OrthoDB" id="1751860at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="35072" checksum="3700CEC1E488AE12" modified="2011-06-28" version="1">MRWLIWRQHRTEVCVLGLLVGLFGVALLVLGTQAHDLFPGGPARCAGEAGVDEACTAAFRRLDEEYGYLENLLAAFYLVPVVIGAFLGAPLLARELEDGTWQLAWTQAVPRMRWLAAKLVALAGVTVALTGMFTVVLTWFRQPFDAWEGRFQYDAFDLEGLVPMAYALFAFGVATAAGAILRRSLPAFGVAFGAFVAARMSVALLARPAYATPLTTMAPVPVGGAKDQAGHSVADWTIERGYADATGRRLSSTEYYELEEAANQAGTNLNQFLHARGVQQFGVHHPADRFWTFQLIEAALFIAVAAILIGVVVWRVRRRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5L6</accession>
    <name>F4F5L6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Atpase aaa-2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_15585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732893.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15585"/>
    <dbReference type="EnsemblBacteria" id="AEB44229">
        <property type="protein sequence ID" value="AEB44229"/>
        <property type="gene ID" value="VAB18032_15585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15585"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_11"/>
    <dbReference type="OMA" id="KRYITDH"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="36"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB44229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="825" mass="90167" checksum="2FB3901BFDE82394" modified="2011-06-28" version="1">MSLDAFRIPGGSLDDLVSRFFGGDPFAGRPVERVDLSRLLSTESRQLLQRAAEQATEWGSPYLNVEHLLWAAAQSDPTRRILDASGADSDDLARQIESAVPRGRPREDTPPLAPAAKRALLDAHRESRRSGATYIGPEHLLLGIAANPETTAGRALRALGEAVTGPTPPAGGAGGRGASSTPTLDQYGRDLTEDARAGRLDPVVGRDDEIDDTIEVLSRRTKNNPVLTGEPGVGKTAIVEGIAQRIINDDVPETLANRRVVALDLSGMVAGTKYRGEFEERLKNVIQEVTAAEDELILFIDELHTVVGAGGGGEGAMDAGNMLKPALARGELHVVGATTLNEYRRYIEKDPALERRFQPILVSEPSVEDSVAILKGVRDRYEAHHQVRYTDEALDAAAELSHRYITDRFLPDKAIDLLDQAGARVRLRSRTPAPDKKEIEKRLSQLRREKDSAVANEDYQRAGALKAEIGAAERDLAAAQEGTPPVPEVHMSDIAEVVSRRTGVPVTQLTEVEKQRLRRIEEQLHERVVGQHEAVRAVAAAVRRSRSGLSDPQRPDGSFLFLGPTGVGKTELARALAAALFGDESSMIRFDMSEFQEQHTVSRLVGAPPGYVGYEEAGQLTEAVRRRPYSVLLFDEVEKAHADVFNALLQVLDDGRLTDAQGRTVDFSNTILIMTSNIGADRILAAQTAGRPVSDQREELMGLLGQRFRPEFLNRIDEIIIFTGLDRDQLLEITGLLLDRTRRRLHAQDINLEVSPDATQWLANRGYQPEYGARPLRRSIQRELEDRLSTLLLEDGANPGDTIEVNVVGGELDLSVRPAAASAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5P5</accession>
    <name>F4F5P5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732922.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15740"/>
    <dbReference type="EnsemblBacteria" id="AEB44258">
        <property type="protein sequence ID" value="AEB44258"/>
        <property type="gene ID" value="VAB18032_15740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15740"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692514_0_0_11"/>
    <dbReference type="OrthoDB" id="1287149at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="398" mass="43835" checksum="E17274F217171B71" modified="2011-06-28" version="1">MTDQPAWQLILTAARQLAEHKLDFSRAELIAEVQRLHPTRHPHSLGPVIQGMTRDTTGGPPSPCGTPLIRVGHGRYTLADRSRSPSSSTAQPTITAQRPSGQSRPAEPGEARADIALIGCVKSKLDHPAPARDLYVSPLFIRRRAYAERHARRYYILSAEHGLVLPETVLAPYDTALAEQSKDYRRVWGQWVAAKLMRAESKVRDRVVEIHAGDEYAQAIVLLLTQAGATVRRPLAGLPLGEQLAWYDRQPQPPAPEQPVAPTKPPETIRPLAPTGTPAPVRPDARAVVTALLKYGREHQAERAGTPPRFTPHPEANTLILTDPFAFLLTVIFDQGIPAERAWKAPYDLRQRLGHLDPARLVAEPEQVRAAVAQPTALHRFINNMPGWLVAAAILVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5S5</accession>
    <name>F4F5S5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15890"/>
    <dbReference type="EnsemblBacteria" id="AEB44288">
        <property type="protein sequence ID" value="AEB44288"/>
        <property type="gene ID" value="VAB18032_15890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15890"/>
    <dbReference type="eggNOG" id="ENOG50336WS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058041_0_0_11"/>
    <dbReference type="OMA" id="WWSEART"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025855">
        <property type="entry name" value="Replic_Relax"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13814">
        <property type="entry name" value="Replic_Relax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="31473" checksum="0AFE0BBFA801933E" modified="2011-06-28" version="1">MATSRSAGLLAIYPHITGRDRRLLQLLDEHQVLTTDQIHRMLFQARRTCQLRLGELAALGLLDRFRFHRDGGGTRPWHWTLGHLGHRFQAAAHHRPEPTVRATRQIVHRLSANPHLTHLLLANEFFVRLTAHARHHPGTSLDRWWSETTTTKQFRTITADGHGLWSSGDTTVGFFLEADTGTEPLGRVVAKLDRYAQLTRRGGPRYPVLFWLGSAHREEHLHRLLGGEVPCATATHAADPADAVWLAAGTTARVRLADLPSDHGQPVADNPTFDDDGVFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5T4</accession>
    <name>F4F5T4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732961.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15935"/>
    <dbReference type="EnsemblBacteria" id="AEB44297">
        <property type="protein sequence ID" value="AEB44297"/>
        <property type="gene ID" value="VAB18032_15935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15935"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089320_0_0_11"/>
    <dbReference type="OMA" id="TRIWSRW"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="214" mass="23498" checksum="50688BB26799E028" modified="2011-06-28" version="1">MIRSVVFDVGETLLDDTREFQAWADWLSVPRHTLSALVGIVVAQGRNNAEAFQYLRPGIDLTAERERREAAGLGEQIGEADLYADVRPAMTELRRRGVWVGVAGNQTVRAAHLLRTLALPVDAIATSGEWQVAKPDPLFFARVVEFAPGEPSEILYVGDHRDYDVTAAHAAGLRPALIKRGPWGHLWADDPAIADTGAWVLESLEELADLVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Y2</accession>
    <name>F4F5Y2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734194.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22205"/>
    <dbReference type="EnsemblBacteria" id="AEB45541">
        <property type="protein sequence ID" value="AEB45541"/>
        <property type="gene ID" value="VAB18032_22205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22205"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_0_0_11"/>
    <dbReference type="OMA" id="LYANELC"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="408" mass="45945" checksum="303540AD2694E7CD" modified="2011-06-28" version="1">MNQLTDVDLGDPELYVSGNPYQVWDHLREHAPMYRNRRPDGSEFWAITTHRLATAVYEDRQSFTSERGMRIGGEGAAGRASAGKMLIVTDGTRHRRMRDVLNPAFTPRSVRRLEESMRAIVRQLLHEVRDLDSFDFVDRIAGRLPLYVTCQLLGVPRNDWDLMIELTRTAFGSVTEDGGDPISAELQEQAHADIFLYSSDLIAERRRRPGDDLVSAMVTGQSAGYRMSDEDIQVNINGILTGGNETTRHATAGGVLAFIDNPTQWQRMRHDTEAVMATAVEEILRWTAPSLHVMRTALTDVVVGPQLVEAGEQVTIWNPAVNRDEAAFPHASRFDITRWPNRHVTFGMGQHFCIGAALARLELRVALDALASQVARFELTGPVRRLRSNLMWGLDQLPVRIHLEDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6A6</accession>
    <name>F4F6A6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_09670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731723.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09670"/>
    <dbReference type="EnsemblBacteria" id="AEB43052">
        <property type="protein sequence ID" value="AEB43052"/>
        <property type="gene ID" value="VAB18032_09670"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09670"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021126_0_1_11"/>
    <dbReference type="OMA" id="HMRTLHL"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="317" mass="33937" checksum="1649BBC68E472C1C" modified="2011-06-28" version="1">MSAGGGTRAIVAALLANLGIAVTKFVAYLLTMSSSMLAESIHSVADTGNQALLLVGGKRARRAPTAQHPFGYGRERYVYAFIVAIVLFSLGGVFALYEAWHKWSDPHGITSWHWVPVTVLLVAIVLESFSFRTAIKESNLVRGRQSWTRFIRRSKAPELPVVLLEDFGALVGLLFALFGVGMTLATGDGRWDAAGTAMIGLLLVTIAIVLALETKSLLLGEGAEPAEIAAIEQAVTGGPEVERIIHMKTLYLGPDELMVAAKIAVARWETAEELARGIDAVEARIRAAVPTARVIYLEPDIYRGEVGPAEASGRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6E2</accession>
    <name>F4F6E2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_09850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731759.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09850"/>
    <dbReference type="EnsemblBacteria" id="AEB43088">
        <property type="protein sequence ID" value="AEB43088"/>
        <property type="gene ID" value="VAB18032_09850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09850"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_10_11"/>
    <dbReference type="OMA" id="DFWSSSM"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="192" mass="20671" checksum="D7611F7DB1974F26" modified="2011-06-28" version="1">MARRRDLVDQQQRLSAATWSVLAERGLPGLTLRAVAERAGCTTGMVLHTFADKQALLVHARELLHRRTGQRADAAQAAADTPRAALRAVLWQAASPTEEKREEARVWLGFLAAALADPVLADLHRSYNRRFVDRVAALVAAVCPDRPSADCRATATSLVALVEGLNALAAVDPATYCDQTQRAAIDAALAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6F8</accession>
    <name>F4F6F8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_09930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731775.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43104">
        <property type="protein sequence ID" value="AEB43104"/>
        <property type="gene ID" value="VAB18032_09930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09930"/>
    <dbReference type="HOGENOM" id="CLU_2848625_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="65" mass="6816" checksum="B0BCAAF8114A5ED7" modified="2011-06-28" version="1">MSSPTRQIDRDTADLLLDGDPVALSRVGRLAATLRALRGPARPGELAGEPAAVAAFLARLARRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6G1</accession>
    <name>F4F6G1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09945"/>
    <dbReference type="EnsemblBacteria" id="AEB43107">
        <property type="protein sequence ID" value="AEB43107"/>
        <property type="gene ID" value="VAB18032_09945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09945"/>
    <dbReference type="eggNOG" id="COG3371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094600_0_0_11"/>
    <dbReference type="OMA" id="CFVMLGR"/>
    <dbReference type="OrthoDB" id="1962568at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="26367" checksum="5661FF1E1B75D779" modified="2011-06-28" version="1">MSNPGRVARRVSDSRSDHRPGTPATGRQDEEANMATATTARPEVAGTGKQRTTGVLLAGGIAAGPVFAVSVTAQVLTRDGFDLSRQPLSLLALGEHGWIQIATFVMTGLLALAGAAGMRRVLPPGQPGALWLPRLVAVFGLGLIVGGVLVADPSMGWPAGAPQGPAETMSWHAVGHGVGAMLAFCSLTVGCLVFARREARLGRPGAAVLSVAGAAVVVLVMAWPHQDSISVRMALGSAVLFGWLSVVCARLLAVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7A1</accession>
    <name>F4F7A1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731830.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10205"/>
    <dbReference type="EnsemblBacteria" id="AEB43159">
        <property type="protein sequence ID" value="AEB43159"/>
        <property type="gene ID" value="VAB18032_10205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10205"/>
    <dbReference type="eggNOG" id="ENOG5032UPT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113619_0_0_11"/>
    <dbReference type="OMA" id="DHNFKDY"/>
    <dbReference type="OrthoDB" id="1200272at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="209" mass="23636" checksum="A9311180D49E7AFE" modified="2011-06-28" version="1">MARGGIFCVEGQWHRDLNERGSVLPTLELLERLGKIRFIHKDAATRDELFYFVDRWLLKQYADHRLGFFAMHGEPNRLCLTDWHSVELTEVAERMAGRCEGRRLYFGSCSVLRAPESALREFLAVTGAALICGFTREVDWVESAAFETVLLDVLANGQRHNAAELRMGSAHWAPLASYLGFRIIYANGRAWRPSVRPRVPSQSTAGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7C0</accession>
    <name>F4F7C0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase 15-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_10300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731849.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10300"/>
    <dbReference type="EnsemblBacteria" id="AEB43178">
        <property type="protein sequence ID" value="AEB43178"/>
        <property type="gene ID" value="VAB18032_10300"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10300"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010399_3_1_11"/>
    <dbReference type="OMA" id="LINAAWR"/>
    <dbReference type="OrthoDB" id="318658at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="229"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="597" mass="65369" checksum="1C7843C9CAFF05C1" modified="2011-06-28" version="1">MQPPISDYGFLSDLRSSALVSRDGSVDWWCPQRFDSPSVFARLLDPGGGHWRLAPAAAGSAGHRVHRSYQPDTLVLRTVHRTPEGSVAVTDALAGEPGARAHELGMNSPAVLVRVVEGLSGRVPMTVEFRPRPQYSLTAPYLKERADGAVLAGAGPVDLVLRCHGLRLRADDDRVRQSFEIAEGQVLGFDLAYGAAYGDPPAELDPVAAVTDTVQAWQAFRELHQYEGRYQDLVRRSATVLTGLTYARSGAVTAAATTSLPEVIGGDRNYDYRFAWLRDFAMTLRALWVAACPAESSRLFAWATRSIGRIGAEPIPVLFGLEGERDVYEHECPRLAGYAGSTPVRVGNDAWQQRQSDVPGEIVSAAWLLRDYLGDEFDDEMLEMVLGLTEQVAATWRLPDRGIWEPREKERHFLSSKVLCWVALDKAVQLGPHLGERADVRRWAAIRDEIRATVLREGFDERSGAYTGAFGSSELDASALYLPVMGFLPADDPRMRATIAAVERELGGPGGLIRRWQDEPGGFLLCSFWLVECLAMAGERERAASLFEQITGHANDLGLLSEQIDLDSGAHLGNTPQALSHIGLINAAWRLTESGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7D6</accession>
    <name>F4F7D6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_10380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731865.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10380"/>
    <dbReference type="EnsemblBacteria" id="AEB43194">
        <property type="protein sequence ID" value="AEB43194"/>
        <property type="gene ID" value="VAB18032_10380"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10380"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_11"/>
    <dbReference type="OMA" id="GIRRWPE"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="9"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="321" mass="34526" checksum="03E47C0250DA6277" modified="2011-06-28" version="1">MARYESLLDACGGTPLVGLPRLSPTVPEGAPPVRLWAKLEDRNPTGSIKDRAALFMVRAAEAAGRLRPGDTILEPTSGNTGISLAMVAKLRGYRLVCVMPENVSTERVQLLRMYGAEIIFSPAAGGSNQAVATAKQIAGEHPDWVMLFQYGNEANARAHYETTGPELLHDLPTITHFVAGLGTTGTLMGTGRYLREKVEGIQIVAAEPRYGELVYGLRNIDEGYVPELYDATVLNRRFSVGTRDAVLRTRQLVEVEGLFVGFSTGAILHAALAVAHEAVRDGRRADVAFVVSDGGWKYLSTGAYGGTLADAEEALEGQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7E4</accession>
    <name>F4F7E4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="14" type="ordered locus">VAB18032_10420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731873.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10420"/>
    <dbReference type="EnsemblBacteria" id="AEB43202">
        <property type="protein sequence ID" value="AEB43202"/>
        <property type="gene ID" value="VAB18032_10420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10420"/>
    <dbReference type="eggNOG" id="COG2987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018868_0_1_11"/>
    <dbReference type="OMA" id="LVGDWAN"/>
    <dbReference type="OrthoDB" id="100619at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
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    </dbReference>
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    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
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        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
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        <location>
            <begin position="138"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="537"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <position position="407"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="50"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="128"/>
        </location>
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        <location>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="547" mass="59087" checksum="4A135179A7A3FFB4" modified="2011-06-28" version="1">MTHAAPGPVRAARGPERTARGWPQEAALRMLMNNLDPQVAERPDDLVVYGGTGKAARDWPSYHALVRTLTDLRDDETMLVQSGRPVGVMRTHEWAPRVLLANSNLVGDWATWPEFRRLEQLGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVAAKRFDDTLAGTLTLTGGCGGMGGAQPLAVTMNGGVCLIVDVDRSRLDRRVHDRYLDEVADDLDDAVQRVLAAKRDRRALSVGVVGNAATVFPELLRRGVPIDIVTDQTSAHDPLSYLPVGVELDDARDYAAAKPAEFTDRARESMARHVEAMVGFLDAGAEVFDYGNSIRGEARLGGYERAFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIAATDRAILDLFPENESLARWIRLAGERVAFQGLPARICWLGYGERDKAGVRFNEMVASGELSAPVVIGRDHLDCGSVASPYRETEAMADGSDAIADWPLLNALVNTASGASWVSIHHGGGVGIGRSIHAGQVCVADGSTLAGQKIERVLTNDPAMGVIRHVDAGYPTPHTDVRIPMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
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        <name type="synonym">Verrucosispora maris</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
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        <property type="term" value="F:kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
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    </dbReference>
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        <property type="entry name" value="CHP03843"/>
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        <property type="entry name" value="TIGR03843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="267" mass="29132" checksum="428319DCD0EA58D0" modified="2011-06-28" version="1">MTPRQDGVAAMRLLRDGELTVEGRLVDASNTTLRGILTLDGTTARCVYKPVRGERPLWDFPDGTLAGREVAAYLVSAATGWDLVPPTVLRDGPFGPGSCQLWIDEPDDAEPLVGFVPADAVPPRWFPIAAARDDDGTPYALAHADDPRLARLAVLDAVINNADRKGGHVLLGPDDRIYGVDHGVSFHVEEKLRTVLWGWAGRPLPTDALEVLDRLAGQVRGPLGTELAEHLTLSEITELAARIDRLCRRGRFPQPSRDWPAVPWPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7W4</accession>
    <name>F4F7W4_MICM1</name>
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        <submittedName>
            <fullName evidence="2">Roadblock/LC7 family protein</fullName>
        </submittedName>
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        <name evidence="2" type="ordered locus">VAB18032_29341</name>
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    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
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            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AEB46939.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="139" mass="14307" checksum="30D838CBC2ABD761" modified="2011-06-28" version="1">MQSTRQSANLDWLLDDLVERLPAARRAVVLSADGLLLGSSAELDQADAEHLCALASGLASLARGASRHLAGGPVRQTVVEMESAYLFVTAAGQGACLAVASDTDADIGLVAYEMAMLVTRVGENLQAPVRASLGAADAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F851</accession>
    <name>F4F851_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-related transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_10470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AEB43212">
        <property type="protein sequence ID" value="AEB43212"/>
        <property type="gene ID" value="VAB18032_10470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10470"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_0_2_11"/>
    <dbReference type="OMA" id="GSFIYNK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="114"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="356" mass="38582" checksum="7C24CB3E5E9D63DC" modified="2011-06-28" version="1">MSSGEQAGTVVPEQTLPAGDTDGSENAADPTARKPRRRWLRITLISVLVLALVGVGAVVAAGFYLKSVESDIERLDAFDGIPEETRPEVVEAGALNMLILGSDSRDPESTGGSRADTIILAHVPKDRSGAQLVSIPRDTWVSIPRTKEGRGGRDAKINAAYAWGGLPLMVQTVEQYTKVRIDHVLMVDFAGFTEIIDALGGIEVNSEKKFTSIHPPFRTFEQGRQRMDGATALDFSRQRKQFADGDFTRIKHQQQVIKAILDKAASGGILTNPSNLNSFVRATSSAVSVDKDMSLVDMAMDLRGLRGNDLTFMTNPTKGTGRVGSESVVFDDSDKAANFYDAVRRDSVKEILNLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8B5</accession>
    <name>F4F8B5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_10790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10790"/>
    <dbReference type="EnsemblBacteria" id="AEB43276">
        <property type="protein sequence ID" value="AEB43276"/>
        <property type="gene ID" value="VAB18032_10790"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10790"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_3_11"/>
    <dbReference type="OMA" id="CSIWPMI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="282" mass="31017" checksum="9D3593C86C359703" modified="2011-06-28" version="1">MTKHPDRIAVAERTAGPDVARRPGVGSRIAASLGYSLGLPMLLLVVWGLLATRSTNRFFPDPLTIFEAFVDTWVGPAFVEDVLPSLYRLGLGITASIVVGIAAGTIIGLMQWLRELLEPLLEFFRAIPPPVLIPVAMLLLGITDTMKVVVIVSGAVWPILLNTIEGVRATDSVMTETADSFQVTWWERLWFLVLPAASPRIMAGVRQGLSVALILMVISEMFASSAGLGYRIAYFQRNYLIAEMWSGILLLGLVGVFLAVVFGIVERRVLRWYHGLREVNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8D7</accession>
    <name>F4F8D7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733139.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16890"/>
    <dbReference type="EnsemblBacteria" id="AEB44482">
        <property type="protein sequence ID" value="AEB44482"/>
        <property type="gene ID" value="VAB18032_16890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16890"/>
    <dbReference type="eggNOG" id="ENOG5030KI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100166_0_0_11"/>
    <dbReference type="OMA" id="PPNTHWS"/>
    <dbReference type="OrthoDB" id="1643427at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="23814" checksum="F79BEA598301BF59" modified="2011-06-28" version="1">MRSAEVLEQLDAAAEEFLFPDLGHGYYYAVDARLHGYRDAGRWALIVETVGYSPRAGNLIDVLHVFGNCLTSGEPGYGNGDFHERVDNWNQIEDPDEPETYRGGPVVVRGRTIAVAAEPGEDLVNVLRQLVPRHRELLLADEGELRRRIPVDLPEVLRLDQWNHPDLVSGLRPSDSETFHQIADVLATGDLSRYAPSLPPNTHWSNWPESGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8Q1</accession>
    <name>F4F8Q1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_23480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734446.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23480"/>
    <dbReference type="EnsemblBacteria" id="AEB45794">
        <property type="protein sequence ID" value="AEB45794"/>
        <property type="gene ID" value="VAB18032_23480"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23480"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_0_1_11"/>
    <dbReference type="OMA" id="RPHEVSI"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="338" mass="36834" checksum="914233AC97CFFF13" modified="2011-06-28" version="1">MSEMSYVAAGLQSIGTPSLWAITIAGVIALLVLDFVVTRRPHEVSLKEALGWSAFYIALPLAFGAWVWSQYGRREGIDYLAGYLVEKSLSVDNLFVFMLLLAAFAVPSVLAQRVLLFGIAGALVLRGIFIALGAAALQTLDFAFLIFALILLFTAAKLLRDAFTGHEQSVDIANMRSVRLLRRFMPVVNEYHGTKMTVRVDGRRALTPLALVVVAVLATDVVFAVDSVPAVYGITEDPYLVFATNAFALLGLRALYFVLHAALSRLVHLSYGLAIILAFIGVKLGLHWAHGIWESVPIIPTEISLMVIVAVLIIVTITSLRATRNVVPGSKEVVTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8V6</accession>
    <name>F4F8V6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate binding family 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_29826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735684.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_29826"/>
    <dbReference type="EnsemblBacteria" id="AEB47036">
        <property type="protein sequence ID" value="AEB47036"/>
        <property type="gene ID" value="VAB18032_29826"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_29826"/>
    <dbReference type="eggNOG" id="COG2273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042406_0_0_11"/>
    <dbReference type="OMA" id="FDVMENV"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313693" evidence="3">
        <location>
            <begin position="41"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="38"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="355"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="484" mass="50638" checksum="4BCA13B55D6EA3C0" modified="2011-06-28" version="1">MTPTPAAAAAPPARRRLPLALAVLVTATTGLAGLTATADAAVPPTPSGWSLVWSDDFTGAAGTLPSGSNWIIDTGTSYPGGPPNWGTGEIQTYTNSTANVSHDGAGNLRITPLRDGAGNWTSARIETVRSNFKAPAGGVLAIEGRIQMPNVTGAAASGYWPAFWALGSPYRGNYQNWPGIGEFDVMENVNGLNTVWGVLHCGVAPGGPCDEFNGIGASRACPGSTCQSAFHTYRFEWDASISPQQLRWYVDGQLYHTVSQSRVGEPYWSQMTSHAGYFLLLNVAMGGAFPNGVAGSATPTSATVPGRPMLVDYVAVYTRGGGSNPPPTTPPPTTPPPTTPPPTTPPPSGVRDAYATIQAESFNAQNGVLVEACSEGGQNIAALRNGDWVRYDNVEFGSSGPRDFVARVASGAASGVSGLVEVRLDSPTGTPIGSFAIANTGGWQSWRSVPGNVSSVTGRRTVYLTFSSGQPNDFVNVNWFHFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9D2</accession>
    <name>F4F9D2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma-24 subunit, ecf subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_11040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731997.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11040"/>
    <dbReference type="EnsemblBacteria" id="AEB43326">
        <property type="protein sequence ID" value="AEB43326"/>
        <property type="gene ID" value="VAB18032_11040"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11040"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_11"/>
    <dbReference type="OMA" id="QVFLGVW"/>
    <dbReference type="OrthoDB" id="1992113at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="22264" checksum="1D089C68F35053E4" modified="2011-06-28" version="1">MTEIRQQPDTPEDELARRFRAGDERALREAYERYGRAVLHLATSTLVNRSDAEDATQATFVAAWLGRDTFDPTKGSLVGWLLGIGRRKVIDRLRSSARESRVVETVRQLPEPVPPGNDPDTVVDRLVVADELARLPDEQRRMLELAFFDDLTHQQIAAVTGVPLGTVKSHIRRGMASLKRRWEVDGAASGARPADISGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9K8</accession>
    <name>F4F9K8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_17420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733241.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17420"/>
    <dbReference type="EnsemblBacteria" id="AEB44586">
        <property type="protein sequence ID" value="AEB44586"/>
        <property type="gene ID" value="VAB18032_17420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17420"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_11"/>
    <dbReference type="OMA" id="AKAMWIK"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="42165" checksum="CF719E6FE9C8D07B" modified="2011-06-28" version="1">MLETVRGPRQLIVGEGVAQNIPRVVAESGSRVLIVTDQVLLGQPGVADIVAAVREKVEVVEVFSDATADVPLTDVALAVSAAAEVDADVILAIGGGTVIDLAKIVGVIRRHGGTPRDYYGESRVPGPTIPLVAVPTTSGTGSELTPVSVLTDPDRALKVGVSSVHIVPDFAIVDPELTYTCPATVTAHSGIDAFCHAVESYTARPRAHGPRDPVEQVFLGRNPVTDHYALQAARRIARSLRRAVSNGGDTQARADMSYGSMLAGLAFSHAGNAAPHALQYPIGAATHTPHGLGVGLLLPYALDAARDAIGDRLAVLARVCGLDVTDASDAEATDTFLTWLDGLLADIGIPPTLADIGVARADLPRFAEMASGVTRLIQNHPGPTDTASLTAILEAAWTGDRTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9V1</accession>
    <name>F4F9V1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734529.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23895"/>
    <dbReference type="EnsemblBacteria" id="AEB45877">
        <property type="protein sequence ID" value="AEB45877"/>
        <property type="gene ID" value="VAB18032_23895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23895"/>
    <dbReference type="eggNOG" id="ENOG503324R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171669_0_0_11"/>
    <dbReference type="OMA" id="VCLDTVT"/>
    <dbReference type="OrthoDB" id="1860119at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="112" mass="12634" checksum="6258405149E26FFC" modified="2011-06-28" version="1">MRWIHRDSVIRCDHDGRVRNQASQQWVTIAGVPTLVADDPKGRTIVACPNYGTTVKPCTTTEAVRVGYSRWVRVDGRPVVLSHLEGFTNGSPPGQFTYRVRDPRQRFVAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA23</accession>
    <name>F4FA23_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase s8 and s53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_00250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00250"/>
    <dbReference type="MEROPS" id="S08.069"/>
    <dbReference type="EnsemblBacteria" id="AEB47134">
        <property type="protein sequence ID" value="AEB47134"/>
        <property type="gene ID" value="VAB18032_00250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00250"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007528_0_0_11"/>
    <dbReference type="OMA" id="RVEYYNT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017297">
        <property type="entry name" value="Peptidase_S8A_DPH-A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037854">
        <property type="entry name" value="Dihydropyridine_esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309187" evidence="6">
        <location>
            <begin position="26"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="224"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1112" mass="116370" checksum="0AD5674F9ED62CF4" modified="2011-06-28" version="1">MQRRSKLTAIGLGLALVLGVPGAAAATPPGPAAPQSAQLTARPAAPGQSTVTLITGDRVTVSASGAASVRPAEGRSGIRFLTQRQQDHLWVVPQDALSLIRDGRVDRRLFDVAGLIAAGYDDARRDHLPLLMTYQAGVAARRAAAPDGVTVTRDLAAIGGVAATADKRETSEFWATLAGSAAAARLDGAGGVERVWLDGRRQLTLEHSVPQIGAPAAHQAGYTGQGVRVAVLDTGVDAAHPDLVGRVAEAQNFTEEADAGDLVGHGTHVAATIAGSGAASGGRNRGVAPDATLLNGKVCEEWGCTESAILAGMHWAAVDQQADVINMSLGGADSPAIDPLEEAVNTLTEQTGALFVISAGNSGRAGSVGSPASAEAALAVGAVDRDDELAYFSSQGPRVGDDGLKPEITAPGVDIVAARGAGTELGEPVGEHYVTLSGTSMSAPHVAGAAALLAQQRGDATAAQLKGILMASAQPHPDLTAYQQGAGRVDVARAISQYVVSEPASLSLGRTIWPHDDDEPVTRELSWRNTGATAITLDLTVQATGPGGQSAPDGMFSLSTQQVVVPAGGTASATVTADTSIDSPDGHYTGRVLARSGDTVVTTPLAVNKEVESYDVTLKHLGRDGAVAGDHFTFLLGLANFDEYVAYDPSGTTEVRVPKGRYGLVSYLFDEATEQVTMMAGPELEVKRDTSVTIDGRKAGAVRLTVPDRSAKSAVAAAEATFLLGDLGAASFGALGDDFDGIAIGQLGRPVPADRFVSSVSSQFTDWEAANSTYFYGLGESFPGRLPNGLTKHYRYSDLAKVTHRFQGGYSGMLAERIVYPVFEPDLGGWAAVTRVAVPGQRVEYYNTKQVRWFGELAFGTPVEDLPWLDLVAAYWSEPTAYRAGRHYQETWNGAPYGPSFPTPRWPDDGVTRQGDVIGLAVGLYHDAAGHVGGSVTDAGRTALYRNGKLVGESEEYGWGQFEVPPGTATYRLETSAKRSFTDLSTEVSVAWTFRSGHVRGDKYARLPVSVVRFAPALDARNAAPANRAFVIPIEVQRQAGAPKGRTTSLTVDVSYNGGKTWQKAKVTKAGSGWQAVVKHPRGTGHVSLRASAQDSTGSTVTQRIIQAYRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA38</accession>
    <name>F4FA38_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_00325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00325"/>
    <dbReference type="EnsemblBacteria" id="AEB47149">
        <property type="protein sequence ID" value="AEB47149"/>
        <property type="gene ID" value="VAB18032_00325"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00325"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_2_11"/>
    <dbReference type="OMA" id="TPDWGVM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="115"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="330" mass="35065" checksum="08990EB76A54B7EB" modified="2011-06-28" version="1">MSLSPVDGAVRTGAGDRIPTGRTVGRSPGRLAWMRLRRDRTALVSGAVLGLFVLVALAAPLIEAAYGIGPHDQFQSRLDGFGMPLGHAGGVSGEHFFGLEPRLGRDIFIRLVYGLRTSFFVACTAAVLSTVIGAVLGGLAGYLGGWLDAVVSWLTDLTLAMPFLIVALALTPTLTARFYGQRDEVPPVFGVGVLIAIFAVFGWTSTARLVRGQVVALREREFVAAARASGAGLGHLLVRQLLPNTWAPILVSFSFAVPQFVTGEAALSFIGVGLTEQTPSFGRMIYQSLDYLQTDPAFVLFPGGTLVALVFAFNLFGDALRDALDPRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FA95</accession>
    <name>F4FA95_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05150"/>
    <dbReference type="EnsemblBacteria" id="AEB42156">
        <property type="protein sequence ID" value="AEB42156"/>
        <property type="gene ID" value="VAB18032_05150"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05150"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016728_0_0_11"/>
    <dbReference type="OMA" id="VCEEKHM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07423">
        <property type="entry name" value="MPP_Prp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041780">
        <property type="entry name" value="MPP_PrpE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024028">
        <property type="entry name" value="PNKP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032390">
        <property type="entry name" value="PNKP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032380">
        <property type="entry name" value="PNKP_ligase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16536">
        <property type="entry name" value="PNKP-ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16542">
        <property type="entry name" value="PNKP_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04075">
        <property type="entry name" value="bacter_Pnkp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="183"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP_ligase" evidence="3">
        <location>
            <begin position="464"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP-ligase_C" evidence="2">
        <location>
            <begin position="784"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="842" mass="91421" checksum="CB4538C3FC62B013" modified="2011-06-28" version="1">MVAVLGVPELALVALVGVSGSGKSTFARRHFAPSQVLSSDAFRAMVADDENDQSASADAFDALHYVAGKRLRAGRLTVVDATNLQPHARAALVRVAREHDVLPVAIVLDVPEALAWARTEARADRTFGKQVLARMSRDLRRTYAQLAREGFRKVHVLRGVDEIDAAQIRFERLFNDRRELTGPFDIVGDVHGCRAELESLLGRLGWQLHRDEAGRAVDATHPAGRTAVFVGDLVDRGPDSPGVLRLVMGMVAAGHALCVPGNHEQKLLRKLRGRNVKVAHGLAETLEQLAAEPDEFSAEVATFVDGLVSHYVLDGGRLVVAHAGLKEEYQGRASGRVRAFALYGETTGETDEYGLPVRYPWAREYRGAATVVYGHTPTPQPEWVNNTICIDTGCVFGGRLTALRYPERELVAVPAEREWYAPVRPLTAVPARPDEVLELTDVVGRRHVEHPYSSLTVPAENAAAALEVMSRFAVDPRWLAWLPPTMAPCSTSKLDGYLEHPAEAFADYRAAGVDRVVCEEKHMGSRAVVLVCREADGGPFGPGGGVVHTRTGRPFFGDPLDTELLARVRTAVSAAGLWEELDTDWLLLDCELLPWSAKAGGLIREQYASVGAAGRTALPAALAVLDVAAARGLDVGVLRDRVAGQRADLLAYTAAYRAYVRPTDGLRGVTLAPFAVLAGRKASYADRDHGWHLALADRLCAADPEFFTTTRRQVVDLSDADAVREATDWWLALTADGGEGMVVKPYAGPAARSERGSLLQPGIKCRGREYLRIIYGPSYTEPARLAALRSRSLGRKRGLALREHGLGLAALDALADGAPLWRRHELVFAILACESEPVDPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAI2</accession>
    <name>F4FAI2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="11" type="ordered locus">VAB18032_11475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11475"/>
    <dbReference type="EnsemblBacteria" id="AEB43409">
        <property type="protein sequence ID" value="AEB43409"/>
        <property type="gene ID" value="VAB18032_11475"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11475"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_2_11"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB43409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="287" mass="30426" checksum="BA1888D58662436B" modified="2011-06-28" version="1">MSIDKRRRPSIGHLEAAFGVSMDPELLERALTHRSYAYENGGLPTNERLEFLGDSVLGVVITTALFHNHPDLPEGQLAKLRASVVNMRALADVARGLGPDGLGPYLLLGKGEETTGGRDKASILADTLEALLGAIYLQYGLDTAAEVIHRLFDPLMAESAGRGAALDWKTSLQELTAALGLGVPEYRIEGAGPDHLKTFTAWVVVAGNRYGGADGRSKKEAEQRAAESAWRTLNAQAEADAEADRAEPATVDEPSVAAVTVEPAEVAADDGRAVVDVGQPQVQAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAM9</accession>
    <name>F4FAM9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17710"/>
    <dbReference type="EnsemblBacteria" id="AEB44644">
        <property type="protein sequence ID" value="AEB44644"/>
        <property type="gene ID" value="VAB18032_17710"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17710"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033540_2_1_11"/>
    <dbReference type="OMA" id="DAYHPAC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="340" mass="36615" checksum="8840EBEC0B6C3A4A" modified="2011-06-28" version="1">MVVDLAAALECSVFDLTGQPYTPADRQLDGARIDAERVWRAMMAHPFDGPPVVGAATVEQVDRESSLVRDLYGRCDYAGALRRLVDLLPALHGVTDQRAAYRLMVPVYGVAMGSLLNVGYSAHAWLAAERCAEAAHLLDDPVAVGVAAANRARVSAYTGAYGPARAYCDRAGADLEGSGADTALDVLGFLHLARAHHLAGMKDQTTAEEHLDEAARIAAHTGETTSWDLLWGPSNVALWRMAYLLDTGRPQEALQAAAGVVVGELPAVRQVYYWLDMSRAMVAAERERDAVRMLLAAERVGPQHTRSSTAAREVARGLLRRGLVSTELRGLCERMGVSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAS9</accession>
    <name>F4FAS9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17960"/>
    <dbReference type="EnsemblBacteria" id="AEB44694">
        <property type="protein sequence ID" value="AEB44694"/>
        <property type="gene ID" value="VAB18032_17960"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17960"/>
    <dbReference type="eggNOG" id="ENOG5030MIR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2936479_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="64" mass="7156" checksum="C6CA50335678CB52" modified="2011-06-28" version="1">MQQVRPLDPNHEMREIMLHMVVSVVLGGLLPGFLLGLLAFKVKSRWCPRCGESTHTMPPAEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAT8</accession>
    <name>F4FAT8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18005"/>
    <dbReference type="EnsemblBacteria" id="AEB44703">
        <property type="protein sequence ID" value="AEB44703"/>
        <property type="gene ID" value="VAB18032_18005"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18005"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017999_1_1_11"/>
    <dbReference type="OMA" id="AYGPEAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="716" mass="75973" checksum="F1F2CFBD30DFF973" modified="2011-06-28" version="1">MVGRSGHDPEEDAGSPTFSPSAELPPLSPADLGVLRQVGARWQIGDTVRALPVDPQAGEIRSSAVGGAHRAAMLFLPDAPGQLTATPVVERPDTAQGRVAGGLRRLLLGRPLTSASILRERMSKIVALPVLASDLLSSVAYGPEAMLAVLVLAGSGALGLSLPIAAALVVLMVAVGTSYRQTVRAYPHGAGSYLVASDSLGPRAGLAAAAGLVLDYVLTVSVSVSAGVAAITSALPSLAAYRVPLALVVIGVLLIGNLRGIRVAGNAFAVPTYVFLVAVLGLIAAGFVRAATGGFTVVAPPPTPAVEGLGLLVVLRAFASGATSMTGVEAVSNAVPVFRPTAWRNARTVLTWMISILIVLFVGLTLLFHLNGLVPRADQTLLSQLARLTFPTGPWYAIIQAATALVLLLAANTAFNDLPRLLYFMARDGYVPRRFLHLGDRLALSNGLIALAVAAAAILVAFGGNTHSLIPLYAVGVFLAFTLSQTGMVNHWRHHRDPGWRRRAAINGVGAVLSAVVLVTAAVTKFAAGAWAVVLAVPLLIYLFRRVRRHYDHVQQALGLHPDHPRGVEPAEDAPPAIVPQQVRHLFLVPVARLNQAALRTLAYVGSLGQPALALHVSPERTEADRFREQWNTWGDHIPLETILSPHRVIIQPIAGYASALRLTHPDLTITVVVPDVVVDHPWQRMLHYRTEQRLRRALRRHPGIVVTSLPTHLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAY2</accession>
    <name>F4FAY2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24235"/>
    <dbReference type="EnsemblBacteria" id="AEB45945">
        <property type="protein sequence ID" value="AEB45945"/>
        <property type="gene ID" value="VAB18032_24235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24235"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680836_0_0_11"/>
    <dbReference type="OMA" id="HAFVHTL"/>
    <dbReference type="OrthoDB" id="1322541at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307768" evidence="1">
        <location>
            <begin position="33"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="410" mass="43172" checksum="128E6F75E1B90A89" modified="2011-06-28" version="1">MPMMSRRTLLAALGAVGAATLTGCEPAGGRTAATLPEPLLVELDGGLAVLRDTAPQVLPHAIATADARFIHATAPDGENTALWRIDVATGATSERVRLPGRWVPQTVSTDGTQVALTTEEVSVTTQRPAGRTETPVLIADAGGVRRRLLLPGNVVPEAFTPDHTGLYVLEWLPPHAPDRYRVRVVDLDSGVSGALQTRLKEAIPAGAEEEMRGDGRQAVLAPNRQVLYTLYTHQPDHQHTRDRISGRPGSDVHAFVHTLHLEQRWAYCVDLPGPFGHGPAEGHAMAITPDGTRLLVVDVNSGIVADISTEELTVRRTVAISSGAGSAYAVTDGDRLFVAAGASVVVCALADLGGGVELTTGERITGLLLSRDGSRFYVAGPTALSWHDSTSGRELGRLAVPGLTGVRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBA1</accession>
    <name>F4FBA1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 2-phosphosulfolactate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_05355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15597"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58738"/>
            <dbReference type="EC" id="3.1.3.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ComB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.71" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730871.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05355"/>
    <dbReference type="EnsemblBacteria" id="AEB42197">
        <property type="protein sequence ID" value="AEB42197"/>
        <property type="gene ID" value="VAB18032_05355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05355"/>
    <dbReference type="eggNOG" id="COG2045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094942_0_0_11"/>
    <dbReference type="OMA" id="FPWGEQA"/>
    <dbReference type="OrthoDB" id="1617556at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050532">
        <property type="term" value="F:2-phosphosulfolactate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005238">
        <property type="entry name" value="ComB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036702">
        <property type="entry name" value="ComB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04029">
        <property type="entry name" value="2-ph_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142823">
        <property type="entry name" value="SSF142823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="25449" checksum="E617C8D933BEAB86" modified="2011-06-28" version="1">MAESVHAQSGSGARFDWGLAGAAELGRVCAVLVVVDVLSFTTTVEVAVGRGMRVHPFPWGEQAAEYARRVGAVPAAGRRQVTPEHPWSLSPAALSRAPVVSDLVLPSPNGSAISAAASATGVPVVVGNLRNARAVGRWLLTQGYGSTDEPIGVIAAGEQWPDGSLRPSVEDQLGAASVLDALSGVPGGLSVEAAVALAALASIPDVPAAIRGSVSGRELIGGGFAEDVEIAVRVDSSAVVPLLRQGVFTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBB3</accession>
    <name>F4FBB3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_05415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730882.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05415"/>
    <dbReference type="EnsemblBacteria" id="AEB42209">
        <property type="protein sequence ID" value="AEB42209"/>
        <property type="gene ID" value="VAB18032_05415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05415"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071501_1_0_11"/>
    <dbReference type="OMA" id="GEHYDYL"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="81"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="259" mass="28283" checksum="3806CD6C0175AC81" modified="2011-06-28" version="1">MTGEPRIGDVFGELLRDTLAVATGIGPRPLAGGRVPRPVIEIIERDDGLINGAPAAQYLDGPQEWQPHDHRAVDRVRGATLDIGVGAGRIALLLQERGVPVTGLDISPGALAVCRRRGVRELVHGTVDEHAASGRRYDTFLLLGNNLGLLEGRERAPAFLAALAAMANPGAQVIAHGTDPYGTRDRVHTGYHEQNRRRGRLGGQLRLRLRYRELATTWFDYLVCSPDELADLVRGTAWRLADIDDRDAPYYLATLRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBD4</accession>
    <name>F4FBD4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730903.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05520"/>
    <dbReference type="EnsemblBacteria" id="AEB42230">
        <property type="protein sequence ID" value="AEB42230"/>
        <property type="gene ID" value="VAB18032_05520"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05520"/>
    <dbReference type="eggNOG" id="ENOG5032ZM5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135445_1_0_11"/>
    <dbReference type="OMA" id="WGLIVDG"/>
    <dbReference type="OrthoDB" id="2006747at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="141" mass="14508" checksum="39F49E03CD0241ED" modified="2011-06-28" version="1">MTAGRGDAGRVSIFLAIALVGVLAIIGMAFDGAGQLRTLQRAENLAAEAARAGGQAIDLATAIEGGPKQINRRQARRAVADYLAAAGASGHTVSFPVVDGETQIRVRVSVTYRRAMLGLFGFSNTVTVSGEATARPLTGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBN8</accession>
    <name>F4FBN8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4439 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732169.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11930"/>
    <dbReference type="EnsemblBacteria" id="AEB43500">
        <property type="protein sequence ID" value="AEB43500"/>
        <property type="gene ID" value="VAB18032_11930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11930"/>
    <dbReference type="eggNOG" id="ENOG50334B4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125489_1_0_11"/>
    <dbReference type="OMA" id="EYAAIWA"/>
    <dbReference type="OrthoDB" id="1820696at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029447">
        <property type="entry name" value="DUF4439"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14530">
        <property type="entry name" value="DUF4439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4439" evidence="1">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="146" mass="15477" checksum="E35E16462AA3D0E2" modified="2011-06-28" version="1">MTAPTGTEDPLAAALTAEYAAIWAYGPIGVRLADAERKAAVEAEDAHRGRRDALILELSTGGAAVPPDRPGYALPFPVTDRASALRLAVEVEERTAAFWRAVLPASTGAERDRALSALIEYAVRATRWRRAAGITPLTVAFPGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBX0</accession>
    <name>F4FBX0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylanase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_18340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18340"/>
    <dbReference type="EnsemblBacteria" id="AEB44770">
        <property type="protein sequence ID" value="AEB44770"/>
        <property type="gene ID" value="VAB18032_18340"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18340"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013864_0_0_11"/>
    <dbReference type="OMA" id="HPWPAPW"/>
    <dbReference type="OrthoDB" id="1177619at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312884" evidence="1">
        <location>
            <begin position="36"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="667"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="797" mass="83945" checksum="CE6AED5EE1463D6B" modified="2011-06-28" version="1">MSVPPLSAAPGRVLAAIAAVTLTGAVTATVVAASAAPALAATTTLYASPSGSGSSCSAAQPCSLTAAQTAVRALNSSMSGDIVVQLADGVYRLSSPLRFTAADSGTNGYRVLWQAAPSARPVISGARAVTGWSLVDAGRNIWRANVGAGLDSRQLYVDGAVATRARTQVNRADFTADSTGMRFTSSALSYLNNLANQSRIQMESVNSFTDRYVSVQSISGNQIRMQQPGWSNNNFGYDTFTSPHRPGPLYLSNAYEFLDSPGEWYLDPGSGALSYIPLAGQNMSTARVELPTLQSLLQLGGTYAAPAHHVTFSGITFTGTSWLGASSNQGYVDQQTGAYIYGNWNWPAFSSCHNGCSQFEATRPNWQQMPAAVQISAADNITFTDSAFVNLGQTAIGIGNDANAHASGVGLGASNITVTRSEIARNAAGGIVVGGVRADAHHPSDQRMVNRDITISNNRLHDLGIEYRGIVSVLTTYVTNATISYNEVYNMPYTGMSIGYGWGSNDAGGSNHYADRGLYNYQPRYTTATTAANNRLIGNYVHDVMQQMNDGGCIYTLSANPGALISDNYCLRTNGHFGLYFDEGSRFFTARNNVFSSTGTWATANYWYAENMGNFTVTNNWSTNGSTNVTNGDRGNVVSGNVTVTGGNWPSGAQAVMAAAGPQGGGTPQSVQIVGGQSGRCLEIGGSSTTNGTQAQLWDCHGGTNQRWTYTAGKQLMVYGNKCLDASGQGTANGTLAIIWDCNGQTNQQWNVNSNGTITGVASGLCLDASGYGTANGTKVHLWACHGGTNQQWSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBX5</accession>
    <name>F4FBX5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_18365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733430.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18365"/>
    <dbReference type="EnsemblBacteria" id="AEB44775">
        <property type="protein sequence ID" value="AEB44775"/>
        <property type="gene ID" value="VAB18032_18365"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18365"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001408_0_0_11"/>
    <dbReference type="OMA" id="TYAFEAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307604" description="Beta-xylanase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="6">
        <location>
            <begin position="359"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB44775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1124" mass="121046" checksum="B20A21E0B10AF136" modified="2011-06-28" version="1">MRLWNPSQRSRRRSRTFAVLCSAALVAAITVAPTPAVADEVVLSNDFESGSYAPWGPRGDVTLAIADEGHDSDGSLSVTGRTANWQGPATSATALMRPGNRYTVTAWAKLPTGTEGSAGVHFTVESTPAGGGENTYTWIGDNVTTTADEWVRIGGEYTLPTGLDAATLYVEAEGNTPFLLDDVLITALDGGGGGPEPGTIVIDTDFEDGLDGWGPRDGGPGAPTVTLTDVAHGGTSAALVTDRVNQGAGLGRDVTGLFTAGVTYELSAWLRFAAGQPADQIWLSLASTAGDSQSFSTLAQFETITNSGWTEVTARFTMPAADSAFLYFETRWQGEDVTGNTSDFLADDIVVQVPEPPVIEDLTPLHETTDFPVGVAIDSRETIGAPAQLLTRHFNQITAENHMKPEAWYDEAGNFRPHEQALTMMDFARDNDLRVYGHVLVWHSQTPAWFFTDSAGQPLTTSAADQQVLRERLRTHIFNVAESLSERYGPFGSSTNPLYAFDAVNEVVSDSGEYSDGLRRSEWYRILGESFIDLTFEYADEAFNDVYAAEGADRPVTLFINDYNTEQSGKQARYLALVQRLLARDVPVHGVGHQFHVSLAMPVSALETALETFADLPVTQAVTELDVTTGTPATQAKFIDQGYYYRDAFRIFRAYAEDLLAVTVWGLTDGRSWRSGNGGPLLFDDNLRAKPAYYGAVDGELPARLRTANVFAGDVPLAAAAPTDLTWRKLPLHSVEDVAGFQLRWAPDHLTAYVTVDDTTVSGTDRVSFVLGGETYHVGRDGSGDVPAVAAARDGGYHLVAHLPLAAAAEGDTRTLDVQVRDGDITSGWNTPGAVGTLTLVEELSYVEVREAAEAPVIDGSVDAGWANATTVTTDKQVSGTDGASAQVRTLWRGQTLYVLAEVTDPVVDVSGSDPWIQDSVEIYVDAGNFKNGSFRYDDTQIRINADNVVSFGTGDEGFQANRLESATVRTPTGYTVEAAISLLEYGGLGTFHGLDFQVNDASDGARTSIRNWAEQEGAGYQSTARWGVGRLVAGSNVEVALKQITRWYSDSGGGYCATITATNTSDKPVDWSAVVQLEGDIYDAWNFKRERLADGSYRIRGVDWNRTLKPGASTFSVGYCANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FC60</accession>
    <name>F4FC60_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24800"/>
    <dbReference type="EnsemblBacteria" id="AEB46058">
        <property type="protein sequence ID" value="AEB46058"/>
        <property type="gene ID" value="VAB18032_24800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24800"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="OMA" id="AMFTHYL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="401"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="500" mass="53066" checksum="D7365D9EE91DDD28" modified="2011-06-28" version="1">MLSDLCRIRADAPDAVAVRTATTRGSWVDTTWAQLSADAMAAARRAGWQAPETPVVLVLDGTAAGIATLLGLLEAGVDIVLLEEQTSHLADPRSAVHLLGADTLIGPPAALTAAGDQFAYRWHYTEYRADTGPAGPHASRSSRIYQLTSGSTGEPRAARQTLPGVLAGAVAYRDLFEVTADDIVLVTVPLPHSYGLAGTLCALLAGATLMTLSRFSIRSVLAGLDEGASVLLGMPMVYRLLSPVLRTRPAPPRLRIALSAGGPMNAAADAEARAALRVPVRQIYGITEAGLVACVPYAVQDWPAGSVGRAAPGVSLRVEAITDPTDQEPAHAEPGTTGRLLVRGPALFEGYAGSDTPHLTPDGYYDTGDMVRLDPDGFLTVLGRKGAFINVGGRKVSPQRVERLLGQHRAVRDVFVFGMERDDGEQEIQAAVVLNPDTGVDEVLAYCRAGALMPYEVPHHLHVLERMPRTGMGKVDRQEVLAATRQPPTPSPITRQESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCH0</accession>
    <name>F4FCH0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein serine phosphatase with gaf(S) sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730970.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05855"/>
    <dbReference type="EnsemblBacteria" id="AEB42297">
        <property type="protein sequence ID" value="AEB42297"/>
        <property type="gene ID" value="VAB18032_05855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05855"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014270_1_0_11"/>
    <dbReference type="OMA" id="RYGSARM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="309"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="462"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="686" mass="72909" checksum="00544A145DCDA3FD" modified="2011-06-28" version="1">MAAEAGPAATGGPHEHVRRVRLPADRRTPAAARAVVRSVLAEADLDELLNEALLLTTELSTNAVEHARTELDVEVSADAAGLTVTVSDFAAGPVDELTVGVRNAATEITEVAERGRGLLLVDHFASRWGTTYLPSGKGVWFRLDRRSPSGGGRTTSAGETDGTAATTAPSAGAMSTLMQTLPDPYAEDPLPDFATNLLTRVAEMIGAAGGVVRLDRGDGQGTQVLARYGRQPRPGHDLLRVPLAVHRPYVGELELDAAPTAYARPLAVLTAERLSLHLENDRLRRADVRRQAWLTFLAEASELLAQSLDVELTMALVPQLVVPRLGQWCAVHTTDEWGRLRLAAATHADEAMLPQLHATLRESGPDSIQARLREASRNGTQTPLGAPMEGFAVPLIARGQRLGTLAVGRHQRHRHDPDEIAVLEDVARRAALAIENARIHAERRRIAQALQQSLLPPVLPVVDGIGFAAEYVPTGGDADVGGDFYDVVPLPDGRWLVVIGDVSGKGVQAAAVTGLVRDVIRVLAGDGKPLPELLPRLNETLVERGAGRYCTLALAVVAPSEGDRLDVELHLAGHDRPLLLRSGGGPASFVGSGGTALGLLETISSPSSEITLGPGDCLVFYTDGVTERRRGRELFGIGRLRDAVTPLAGYPADVVAARLRATAINFSVEEPRDDIAILVLRNDAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCQ2</accession>
    <name>F4FCQ2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12160"/>
    <dbReference type="EnsemblBacteria" id="AEB43546">
        <property type="protein sequence ID" value="AEB43546"/>
        <property type="gene ID" value="VAB18032_12160"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12160"/>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_3_0_11"/>
    <dbReference type="OMA" id="LPFWHGD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="281"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1527" mass="162414" checksum="29A1A9D5CCD62FA3" modified="2011-06-28" version="1">MQDGLVDSSAAPTGDSTLPRFGAATREWFSAAFEAPTAAQAGAWTAVAAGRNALVVAPTGSGKTLAAFLWSLDRLAREPAPADPRHRCRVLYVSPLKALAVDVERNLRTPLAGIRQAASRLGLPPPEITVGMRTGDTPADERRAFARTPPDILITTPESLFLLLTSAARDSLRGVETVIVDEVHAVAGTKRGAHLALSLERLDELLPAAAQRIGLSATVRPVDECARFLGGARPVEVVAPISAKTIEVSVQVPVEDMTHLDEAPAPGDELGGPRTASIWPALEERVYALIQAHRSTIVFTNSRRSAERLCARLNELAAEQPVGESPTAPTGAHRTPALMMAQAGAVTGAPPVIARAHHGSVSREERRHIEESLKAGQLPAVVATSSLELGIDMGSVDLVVQIEAPPSVAAGLQRVGRAGHQVGAVSRGVVLPKHRGDLLSCAVVAERMSAATIEELHHPRNPLDVLAQQIVAMVALDQWRVGDLAAVVRRAAPFAELPDSALHAVLDMLSGRYPSTAFAELRPRLVWDRATDVLTGRPGAQRLAVTSGGTIPDRGLFGVFLAGAQRAARVGELDEEMVYESRVGDVFLLGSSSWRIEEITPDRVLVSPAPGQAAKMPFWKGDQPGRPVELGRAIGARIRTLLRHGDEQATAALRATGLDDWAAGNLLAYLREQQAATRALPDDRTVVVERFRDELGDWRLAVHSVLGARVNAPWALAVARRLGERYGLDAQVLPSDDGIVVRLPDTADSPPGADVVAFDPDEIAQLVEESVGTSALFAARFRECAARALLLPRRDPRRRQPLWQQRQRAAQLLDVAREYADFPVTLEAARECLQDVFDVPALVQVMRDLAGRRVRLVEVETPRPSPFARSLLFGYVGAFLYEGDAPLAERRAAALALDSALLGELLGRVDLRELLDPAVLTESERQLRWLTPQRRPRDAEDVVELLRQLGDLSAEELAERGVPVAWLTDLAADRRVLRVRIAGQDRWVVVEDAGRLRDALGVALPVGVAQAYLEPVADPLGDLVARYARTHGPFPAASCAARFGLGVFVVEQALRRLAATGRVVSGEFTPDSVGTQWCDAEVLRLLRRRSLAALRREIEPVPPRALATFLPRWQQVGSSARGVEAVAAVVEQLQGVSVPASALERLVLPVRVADYSPALLDELCASGEVLWAGAGAIAGGDGWVTLAYADVAPLLLPPPDDALARTPLHDAVLDALGDGQALFFRALSDRVGATDDAELTTVVWDLVWAGHLTNDTLAPLRTVLGGGGAHRARPAATRGRYRRPGRVALPSRGGPPTVAGRWSRLPERDVDPTRRAAALADVLLERHGVLTRGAVVAEQVSGGFAAVYPVLAALEERGAARRGYFVDGLGAAQFAVPGAVDRIRALAEPLDATPARGGPAVVLAATDPANPYGAALPWPERVVDSGDAAAPATGHRAGRKAGALVVLVAGDLVLYVERGGRTILSFTDDADALTGAGKALADAVGSGALGPISVERADGEAVRTSALHDALTAAGFRATPRGLRLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD61</accession>
    <name>F4FD61_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_24965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734743.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24965"/>
    <dbReference type="EnsemblBacteria" id="AEB46091">
        <property type="protein sequence ID" value="AEB46091"/>
        <property type="gene ID" value="VAB18032_24965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24965"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_6_11"/>
    <dbReference type="OMA" id="CEAYESF"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="69"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="384" mass="42032" checksum="F4D3940E6645B6D7" modified="2011-06-28" version="1">MSTDFLTDLRAQARAHADLLRPTALDLDRNPDLAVSAPGCGLPWRRFAGLPAEYNPDPLRVDGRPVLLDTCVERVVVLEELARADAAAVLALPGPSMSASVIADLADDDQQQRYWETVATEPTWTFFAMTEPAHGSDPGSMHTTLRRHGDDFRLHGTKRYVGNGVRSRLGVVFARRNAGPLGVVAVLVDTDLPGFTAAPLSTLGLRGLQLSELRMVDVPLTEADILGRQRSATRQGMWAATRTFNRYRPVVSCLALGVAQAAYDLVVTQRRRYRTDERHLLTGWEQRLAGTRALVLAAARAVDADPRDGTLAAAAKLRATRLAEEITTTAVRLLGPGARWEHPMLDKLLRDARAFEFMEGTGNIQRLTLAEGYLQGRLTDVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDE4</accession>
    <name>F4FDE4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="7" type="ordered locus">VAB18032_01355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735991.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01355"/>
    <dbReference type="EnsemblBacteria" id="AEB47355">
        <property type="protein sequence ID" value="AEB47355"/>
        <property type="gene ID" value="VAB18032_01355"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01355"/>
    <dbReference type="eggNOG" id="COG1005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_11"/>
    <dbReference type="OMA" id="MYVGMGI"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="34660" checksum="3A99FB150BD88A92" modified="2011-06-28" version="1">MPLWLELVIRIGGVLVAFLVLPLLVGQAEHKVMAHMQGRLGPMYAGGFHGWAQLVADGVKFVQKEDVTPRAADRPVFRLAPAVALVPYLLALLVIPLGPNDLVGQPLDVGLFFVLAVVGVGVLAVLMSAWASANKYSLLGGVRGAAQLLGYELPLVLAAASVAMAAGTLSLSGIVEAWQPWWLIWQAPAMVVFFLAGLAEIRRPPFDMPVADSELVFGYMTEYTGLRFAFLLLAEYVGIVVIAALTTVLFLGGWQGPFADAQLGWLWTLLKIAAVSFVIIWLRVSYPRLREDQLQRLCWLILVPTALAQLVLTAAVRLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDG0</accession>
    <name>F4FDG0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_01435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736007.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01435"/>
    <dbReference type="EnsemblBacteria" id="AEB47371">
        <property type="protein sequence ID" value="AEB47371"/>
        <property type="gene ID" value="VAB18032_01435"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01435"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_11_2_11"/>
    <dbReference type="OMA" id="WRGIAGF"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="212" mass="22719" checksum="4C08351D5DEBB729" modified="2011-06-28" version="1">MTAVGNGAQTAGRPTRLPRSARRKQLLAAAQEVFVAQGYHAAAMDDIAERAGVSKPVLYQHFPGKMELYLALLDTHCDAIVAKVHDAMASTTDNKERVGASVRAYFDFVDHESEAFRLVFESDLRNDPAVRQRVERVEQGCIAAITDTIISDTGVSRAHAELLASGLVGAAETAAQFWLAGGRQVPKAEAEALVAALSWRGIASFPLQGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDK2</accession>
    <name>F4FDK2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rard protein, dmt superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_06205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731038.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06205"/>
    <dbReference type="EnsemblBacteria" id="AEB42365">
        <property type="protein sequence ID" value="AEB42365"/>
        <property type="gene ID" value="VAB18032_06205"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06205"/>
    <dbReference type="eggNOG" id="COG2962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054508_1_0_11"/>
    <dbReference type="OMA" id="HRMVWSL"/>
    <dbReference type="OrthoDB" id="1391352at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
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            <begin position="37"/>
            <end position="58"/>
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        <location>
            <begin position="70"/>
            <end position="90"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="102"/>
            <end position="119"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="142"/>
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    </feature>
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            <end position="165"/>
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            <begin position="209"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="260"/>
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    </feature>
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        <location>
            <begin position="266"/>
            <end position="286"/>
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    </feature>
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        <location>
            <begin position="6"/>
            <end position="142"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="306" mass="32817" checksum="10D24928151BAE38" modified="2011-06-28" version="1">MTPLRLGYLYGFAAYLMWGFFPLYFKLLRPAGPLEILAHRVVWSVAFVALLLGAMRNIGFLRALLRRPRALAGIAAAAVLIGLNWFTYIYGVNSDRVVETALGYFINPLVVVLLGVAVLRERLRPAQWCALGIGGLAVAVLTVDYGQLPYIALILALTFGGYSLVKKQLGLPAAEGLFVESAVLALPALGYLGWLAATGEMAFGQVSTGHTLLLVIAGALTAIPLLLFAGAANRLPLSSLGMLQYVAPILQLGCGVLIFHEPMPPARLAGFALVWLALIVFTADGLRQARRTRRQPPVTVSPAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDK6</accession>
    <name>F4FDK6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06225"/>
    <dbReference type="EnsemblBacteria" id="AEB42369">
        <property type="protein sequence ID" value="AEB42369"/>
        <property type="gene ID" value="VAB18032_06225"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06225"/>
    <dbReference type="eggNOG" id="COG4842">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="AKFEQVD"/>
    <dbReference type="OrthoDB" id="1999616at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="106" mass="11403" checksum="3DB5BE7E0BACF6D9" modified="2011-06-28" version="1">MSQTQAQAAVMQQTAAKFEQADQSLQSMLSGLLTQLEVLQQAWRGAGGRSFEQVKQQWSQDQAALQRALRETAGAIRTAGVHYDASDAEAASRVSATNRGGIQLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDN9</accession>
    <name>F4FDN9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="7" type="ordered locus">VAB18032_06390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06390"/>
    <dbReference type="EnsemblBacteria" id="AEB42402">
        <property type="protein sequence ID" value="AEB42402"/>
        <property type="gene ID" value="VAB18032_06390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06390"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008049_2_1_11"/>
    <dbReference type="OMA" id="LDRRWTM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Thymidylate_kin" evidence="6">
        <location>
            <begin position="520"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="720"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="522"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="753" mass="78975" checksum="EF7122BBFB328109" modified="2011-06-28" version="1">MPSDGPARGGTAIESQFNGESSGVSPSTNQPTGQAGRSGGTTGQADLTGYPAIRSVLRIRPFRRLWIVLSAASFGDWLGLLATSIFAAAQVEGSTAKGAAFGGVIAIRLLPALLLGPIAGVFADRFDRRWTMVICDLLRFVLFASIPLYALTGASGARVVSWAAIATFLIETVTLLWIPAKEAAVPNLIPRARLETANQLTLITTYGLTPIFAAIVLASLDGIVRGATGGEMPSWAEPAQLALWFNALSRLATALVVAFGIKEISQGQRQRQEQSEQSMLRQFNEGWRYIGKTPLVRGLVLGIFGAFAGGGIVIGTSRFFANSLGAGDAAFSLLFGAIFFGLAIGIGLGPMIVRDMSRRRWFGMSIVLASASVMTLAFAIHLSMALVGAVLVGAGAGMAFLSGTTLLGGEVADEVRGRVFAVVQIGTRLVLILAIALGSLLAGVGGSRKLEIADLGISISATRLLLLVAGAAGIFAGISAFGQMDDKKGVPVLADLWGSIRGRPLMPAEPFVSAGLFVVFEGGEGAGKSTQLAQLAERLRAEGRDVVVTREPGATGVGTRIRSLVLDNNTDDEAPSPRAEALLYAADRAHHVATVVRPALSRGAVVISDRYVDSSLAYQGAGRTLPVDELSWLSSWATGGLKPDLVVLLDIDPRAGLSRVAERSRAADRLEAESLAFHERVRYAFLDLAAADPKRYLVLDAGHPVEQIAERVADRVTELLAPGGADHPGPASGPDTSVQPELSPTELVTTERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDU4</accession>
    <name>F4FDU4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_12555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732294.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12555"/>
    <dbReference type="EnsemblBacteria" id="AEB43625">
        <property type="protein sequence ID" value="AEB43625"/>
        <property type="gene ID" value="VAB18032_12555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12555"/>
    <dbReference type="eggNOG" id="COG2860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064906_1_1_11"/>
    <dbReference type="OMA" id="RAPRAWN"/>
    <dbReference type="OrthoDB" id="1665397at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="218" mass="22227" checksum="C56C0580407527AD" modified="2011-06-28" version="1">MTTSTALLLADLAGVAVFAASGASAAVAKRLDLFGVVFVGFVAALGGGIVRDLVIDEVPPLAFADWRYATTAAVTAGAIFWLHPQFARLRTTVLVLDAAGLGLFTVAGTLKALDAQVPPVGACLIGMITAIGGGLCRDLLTGEIPVVLRREIYAVAALAGSIVVVLLDGLGYAGPIPLVAAVLLVFGLRLVALRRRWSAPVAALRPPPRTGGITGPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDU9</accession>
    <name>F4FDU9_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12580"/>
    <dbReference type="EnsemblBacteria" id="AEB43630">
        <property type="protein sequence ID" value="AEB43630"/>
        <property type="gene ID" value="VAB18032_12580"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12580"/>
    <dbReference type="eggNOG" id="ENOG5032WRF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126943_0_0_11"/>
    <dbReference type="OMA" id="RAYFLNN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307827" description="LytR_C domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="2">
        <location>
            <begin position="52"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="171" mass="18244" checksum="AD2909C0BC8D25BD" modified="2011-06-28" version="1">MRALVIVGTLAVVALVFVVIAVVRDTQSNAGTAEGCPADWPRADVTLRDHKDVKIRVYNGTDRPGLAASVGDDFRNRDFQVEKEANEKKQIDDVAVLRYGPKGVGSAHLLRAYFLGNAALEYDVERPDDVVDVVLGNGFQQLATTTEVNQSIGDLGAPVAPPGSCPMPVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE12</accession>
    <name>F4FE12_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_18895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733536.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18895"/>
    <dbReference type="EnsemblBacteria" id="AEB44881">
        <property type="protein sequence ID" value="AEB44881"/>
        <property type="gene ID" value="VAB18032_18895"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18895"/>
    <dbReference type="eggNOG" id="ENOG5030354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128681_0_0_11"/>
    <dbReference type="OMA" id="PLKLWRP"/>
    <dbReference type="OrthoDB" id="1758560at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025238">
        <property type="entry name" value="DUF4184"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13803">
        <property type="entry name" value="DUF4184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="246" mass="26387" checksum="92DB948BE86E8240" modified="2011-06-28" version="1">MPLTLPSHLAAVLPLKLWRPRWFDGVALSAGAVAPDVAHLMYRADGPGFPDTHTWPALVWWCLPVALAYARIFRSSIGTVAAHLPQNRRFGWWVDGPPAGGGHRLWVTVTSALVGAASHLAWDWLTHTDDWLAVVFGVRWSSVTDVAWWTVSDLTSTALGAVVAIWCLALLGRPDARGTDIPERATRPKAFWGAVIVVAAVGLVTVPMLPGASSPAATGVRLIHLVGAALLAGVLVVRFWPARRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEE1</accession>
    <name>F4FEE1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase-reductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25545"/>
    <dbReference type="EnsemblBacteria" id="AEB46207">
        <property type="protein sequence ID" value="AEB46207"/>
        <property type="gene ID" value="VAB18032_25545"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25545"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_3_11"/>
    <dbReference type="OMA" id="EMMEEAW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="17"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="171" mass="19105" checksum="4807FE2A90CD72ED" modified="2011-06-28" version="1">MDGCCDHLAVSPDEDLHRHHIENLARADALLFGRVLYEMMEEAWRPSASAVSRPDWMEPFARTIDAAKKYVVSSTLEQVDWNAELVQGDLGKAVEQIKRESRTGVFVSGVQLPLALAELGLIDEYEFVVHPRIAGRGPRLFEGLAKHVDLKLESRFELASGASVMRYVPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEK7</accession>
    <name>F4FEK7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_01825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736083.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01825"/>
    <dbReference type="EnsemblBacteria" id="AEB47449">
        <property type="protein sequence ID" value="AEB47449"/>
        <property type="gene ID" value="VAB18032_01825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01825"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_11"/>
    <dbReference type="OMA" id="FYRHQTQ"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="300"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="394" mass="41042" checksum="DA729C9B4E3721C1" modified="2011-06-28" version="1">MRLAEAWRVAADALRANRMRSLLTMLGVIIGVASVVLLVAIGTGTKQTVEQQVEGLGSNLLLVVPGRLDVGSAPAVSPLTLQDVDAVGRVVGDPARVAVTVASGATVRAGNRQDFTTVQGVLETTPTVFARDLGRGRYLTRSDVDTGRRVAVLGDSVARVLFPDREAVGQQVNVAGVRFRVIGVFTPLGQSLGVDRDDEVHIPVTAAQRLYGTQRVDAIAVRAPDRDRIDELGQRIVTELNGRHPGTEFSAVTQEQILGVLGDILGILTGVLAAIAGISLLVGGVGVSNIMLVSVRERTREIGLRKAVGARPRDIGVQFLLEAVLLTSIGGLTGMALGVGGALLVAAVSPIPAAVTWWSLALAFGVSAAVGIIFGVVPAQRAGRLDPVVALRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEL3</accession>
    <name>F4FEL3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_01855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736089.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01855"/>
    <dbReference type="EnsemblBacteria" id="AEB47455">
        <property type="protein sequence ID" value="AEB47455"/>
        <property type="gene ID" value="VAB18032_01855"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01855"/>
    <dbReference type="eggNOG" id="ENOG50323JZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2409975_0_0_11"/>
    <dbReference type="OMA" id="DDDCALG"/>
    <dbReference type="OrthoDB" id="2220593at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="80" mass="7730" checksum="B2392F3D02392969" modified="2011-06-28" version="1">MQLGALTALALALSGCNLVSDDDDDDCAMGPGGGGDTVAMTLRTPAPVPEMGVGSPITEPVATAVPDRGGFGSHQASCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEQ1</accession>
    <name>F4FEQ1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily mfs_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_06605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731118.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06605"/>
    <dbReference type="EnsemblBacteria" id="AEB42445">
        <property type="protein sequence ID" value="AEB42445"/>
        <property type="gene ID" value="VAB18032_06605"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06605"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_2_11"/>
    <dbReference type="OMA" id="FTAQDWL"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="425" mass="45550" checksum="04C2A55BAC031C5B" modified="2011-06-28" version="1">MQARLSTMFQSLQVRNYRLFASGQLVKLIGVWMMFIAQDWLVLELSDDSATALGVVVALQFTPVLLLTLISGRLADRYDKRMLLFVANAFWTVLSLAMSVLVVTGLVQLWHVFVFAALLGVANAVETPVRQAFVSELVGTRLLPNALSLNAAVFNSARIVGPAVAGLAIAAFDVGPVFMVTALSSIAPLVTVIQMRSSELYRPPLPPREERAAATVMDGLRYVGRRPDLLLPMVVMSVIGMALFNFQLTLAALAKTVFNTGAASFGLFSTTLAVGALAGALAGTGRRSRPSVWLVLGAAIACAVFGTLVGLAPTYWTVVALLPPTGFFMVYFAQAANQRVQLGTDAAFRGRVMALWVLVFLGTNPIGAPLVGWVAETFGAGVSIWAGGLVSLATALLALAWQLRRDGARVRFRVLPMPRFYVTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEQ6</accession>
    <name>F4FEQ6_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_06630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731123.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06630"/>
    <dbReference type="EnsemblBacteria" id="AEB42450">
        <property type="protein sequence ID" value="AEB42450"/>
        <property type="gene ID" value="VAB18032_06630"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06630"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_11"/>
    <dbReference type="OMA" id="YWTSAAE"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB42450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="368" mass="39880" checksum="97B456DAA40FE8DD" modified="2011-06-28" version="1">MADFKPGLEGVVAFETQIAEPDREGGALRYRGVDIEDLIGQVSFGNVWALLVDGRFGPGLPPAEPFPVPVHSGDIRVDVQSAVAMLAPYWGLQQMLDISDEQAREDLARVSVTALSFVAQSARGLGLPAVPQKEIDKASTVVERFMKRWRGEPDPRHVKAVDAYFISAAEHGLNASTFTARIVASTGADAAACISSGIGALSGPLHGGAPSRVLSMLEAVERSGDAESYVKGVLDRGERLMGFGHRVYRAEDPRARVLRRTAKDLGAPRFEVAEALEKAALTELQARRPDRVLATNVEFWSAVVLDFAEVPAHMFTSMFTCARMGGWSAHILEQKKLQRLVRPSARYVGPGPRKPHEVDGWDAVPHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FER2</accession>
    <name>F4FER2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_06660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731129.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06660"/>
    <dbReference type="EnsemblBacteria" id="AEB42456">
        <property type="protein sequence ID" value="AEB42456"/>
        <property type="gene ID" value="VAB18032_06660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06660"/>
    <dbReference type="eggNOG" id="ENOG5031RMA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094182_0_0_11"/>
    <dbReference type="OMA" id="GTETHDR"/>
    <dbReference type="OrthoDB" id="1524864at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="247" mass="26752" checksum="6AE6DA3C5DD718BF" modified="2011-06-28" version="1">MARDGDINEPTSRFPDTDLHPDDRSDVPPPPPSGGGAARALLWVLGAAALAVVVLLGVQTTGILPEFRNPFSKEQTDRSQPALLESMQDLSRYVAAEGNFQVVVDLQNDRRNVPDWLLNQRTLFVGSGSVEAYVDFGTLTEGAIVQSADGKSVEIKLPAPQLAETNLDLDKSYVFAEERGLLNRVGDLIGGDPNRQQQVYQLAEDRITAAARDSGLIARAEENTRKMLVGLLASLGFEHVTVTYVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEU2</accession>
    <name>F4FEU2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_06810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731159.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06810"/>
    <dbReference type="EnsemblBacteria" id="AEB42486">
        <property type="protein sequence ID" value="AEB42486"/>
        <property type="gene ID" value="VAB18032_06810"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06810"/>
    <dbReference type="eggNOG" id="COG4288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143451_0_0_11"/>
    <dbReference type="OMA" id="IVQYSRL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.290.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009794">
        <property type="entry name" value="DUF1362"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036698">
        <property type="entry name" value="TM1070-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07100">
        <property type="entry name" value="ASRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008711">
        <property type="entry name" value="UCP008711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89232">
        <property type="entry name" value="SSF89232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="125" mass="13900" checksum="266EDAC7020BB49A" modified="2011-06-28" version="1">MTQLGARVWVVPGGRIPFGGTGPEPEYTSFDQLCVLNTGDAEADLRLDFYYEDTEPVGPYRLVVGARRIRHVRVNDLIDPEAVRLDRPYGCVLRSPVPVVAQFLRQDTRRPGTVALATTIAYPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFE4</accession>
    <name>F4FFE4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellulose-binding family II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_25740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25740"/>
    <dbReference type="EnsemblBacteria" id="AEB46246">
        <property type="protein sequence ID" value="AEB46246"/>
        <property type="gene ID" value="VAB18032_25740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25740"/>
    <dbReference type="eggNOG" id="ENOG5032DVC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1203732_0_0_11"/>
    <dbReference type="OMA" id="MSAFDGG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="227" mass="23490" checksum="A5E90859581EA166" modified="2011-06-28" version="1">MASSPWILVSIGLGAMVVLLVIAVGAYRGPGPDFDPAPPLGAVPVPERATSAGRGPSALPSQVVPGLTPRRTNPPRPAGTTVDSPRPSASAVRSSQPPRPAMPTSSAPTGSTPTRAPAAPASPSPFEARYRVTDSFSGGFIAEVWIRNTSRRDREWVARIEYPGGRVVTAWLEGVPQGTFRGTGGTLTYRSGPDLPAGSAVALRFHIEFASPRPASCTVSGRACTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFF1</accession>
    <name>F4FFF1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_25775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734905.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25775"/>
    <dbReference type="EnsemblBacteria" id="AEB46253">
        <property type="protein sequence ID" value="AEB46253"/>
        <property type="gene ID" value="VAB18032_25775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25775"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140387_0_0_11"/>
    <dbReference type="OMA" id="RGGCWFR"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="123" mass="13632" checksum="279B8BFB89DF3299" modified="2011-06-28" version="1">MIHHVQLACPRDSEDRSRAFYVDLLGLTELTKPPTLAARGGCWFSGYGAELHLGVEDDFRPARKAHPALLRPDLDALATRLTAAGCPVTWSDDLPGLRRFHTTDPHGNRLEFLTPTHPTPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFG4</accession>
    <name>F4FFG4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734918.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25840"/>
    <dbReference type="EnsemblBacteria" id="AEB46266">
        <property type="protein sequence ID" value="AEB46266"/>
        <property type="gene ID" value="VAB18032_25840"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25840"/>
    <dbReference type="eggNOG" id="ENOG50333NE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065124_1_0_11"/>
    <dbReference type="OMA" id="MDPGFAE"/>
    <dbReference type="OrthoDB" id="1759003at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="308" mass="31682" checksum="BC304C1F8E74DD31" modified="2011-06-28" version="1">MIEPAADFDFDTWGVPSRTFLIIYLLATVVLIVGVLIFRRRTLTGRSAPPADQLGPQQVAYLTGGEDRAVWSSVSSLRSQGVLGVGPGGELTADGPLSTGATPLDQAVHYAASQRCSARQLRRTEWVTRALDQLRDGLSRHDLLVTPERRAALRLGALLLAAMVALGVARIVAGIANDRPVWYLVFIVGALAVLTTVLFVRVPRRTRAADAALRSLRQRNRHLAPASNPAYAVYGATGAAMAVALYGTASLWALDPTFAQQAEIQREAVTGGGGTVGGSCGGGSTAGASGCGSGDGGGGGCGGGGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG51</accession>
    <name>F4FG51_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ureB</name>
        <name evidence="4" type="ordered locus">VAB18032_13415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732462.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13415"/>
    <dbReference type="EnsemblBacteria" id="AEB43795">
        <property type="protein sequence ID" value="AEB43795"/>
        <property type="gene ID" value="VAB18032_13415"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13415"/>
    <dbReference type="eggNOG" id="COG0832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129707_2_0_11"/>
    <dbReference type="OMA" id="VVHNTGD"/>
    <dbReference type="OrthoDB" id="1755809at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB43795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="152" mass="17076" checksum="E8041B314B401630" modified="2011-06-28" version="1">MAKQHPGPNSKHLRPIGGYKLSDQPLELNAGRPVIEVVVHNTGDRPIQVGSHFHFFEANRYLEFDRPAAFGKRLNIPATTSIRFEPGDRKTVQLIPFGGLQRVYGFNGLVQGWTGDDPTPPDYRPDRAESLHNARTRGFKFSAQDQGDNKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG59</accession>
    <name>F4FG59_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732470.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13455"/>
    <dbReference type="EnsemblBacteria" id="AEB43803">
        <property type="protein sequence ID" value="AEB43803"/>
        <property type="gene ID" value="VAB18032_13455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13455"/>
    <dbReference type="eggNOG" id="COG2320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086407_4_0_11"/>
    <dbReference type="OMA" id="WQLFPIF"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="181" mass="20520" checksum="EDF8E10AF2DCB7FA" modified="2011-06-28" version="1">MSGAVEIVDYQPAWGVDFTELGSALRIALGDAAQRIDHIGSTAVPGLAAKPVIDIQISVLTLEPVDGFRLPLERLGYVYRADNPERTKRYFREPPGRRRTHVHVRQLGSFSQQLPLLFRDYLRAHPAAAAEYATVKRRYAQQFRHDRQAYVQAKDPFVWQIVRRADGWAQRIGWTPGPSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGA2</accession>
    <name>F4FGA2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733695.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19690"/>
    <dbReference type="EnsemblBacteria" id="AEB45040">
        <property type="protein sequence ID" value="AEB45040"/>
        <property type="gene ID" value="VAB18032_19690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19690"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_4_5_11"/>
    <dbReference type="OMA" id="EAAGIWT"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="165" mass="17650" checksum="AE88FFFB15ECC3E0" modified="2011-06-28" version="1">MAEVVLRPMTAADADRVLTIYQAGLDGGQASFETVAPTWAAFDAGRLPAHRLVAVDEAGTVLGWVAVSPTSTRPVYAGVVEHSVYVDPAAQGRGVARLLLDGLIASTEAAGIWTIQSAVFPENTASLTLHSRAGFRVVGVRERVARHHGRWRDVTLLERRSPVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGB9</accession>
    <name>F4FGB9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19775"/>
    <dbReference type="EnsemblBacteria" id="AEB45057">
        <property type="protein sequence ID" value="AEB45057"/>
        <property type="gene ID" value="VAB18032_19775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19775"/>
    <dbReference type="eggNOG" id="ENOG5031XDT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202298_1_0_11"/>
    <dbReference type="OMA" id="AARWLMV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="58" mass="6312" checksum="7EE978129A52091B" modified="2011-06-28" version="1">MRALLWVVGVVGGIIVLLGLLLEAVRWLVIIGLIALAGVIILAFVRGRQSAHNYPNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGD7</accession>
    <name>F4FGD7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_19865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733730.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19865"/>
    <dbReference type="EnsemblBacteria" id="AEB45075">
        <property type="protein sequence ID" value="AEB45075"/>
        <property type="gene ID" value="VAB18032_19865"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19865"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="AFMYMGD"/>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="32"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="31369" checksum="06A74510F7075336" modified="2011-06-28" version="1">MASNNLTTRPSVAVHAPGSTASGVEPTDAPVMQLRDVSVYYGSYEAVRGTTMPIQQNQVTAMIGPSGCGKSTVLRALNRMNDPIPGARVSGEVSFHGQDLYARDVDPIQVRRRIGMVFQKPNPFPKSIFDNVAYGLRINGIKGRLDDHVEEALTKAALWDEVKDKLRKSALALSGGQQQRLCIARTIAVKPEVILMDEPCSALDPIATAKIEDLMFELTSDYTIVIVTHNMQQAARVSHYTAFFTAEVDDKQVRHGRLVEFSQTGKLFTNPADKRTEDYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGE7</accession>
    <name>F4FGE7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_19915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19915"/>
    <dbReference type="EnsemblBacteria" id="AEB45085">
        <property type="protein sequence ID" value="AEB45085"/>
        <property type="gene ID" value="VAB18032_19915"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19915"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OMA" id="PNIADEP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB45085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="529" mass="55380" checksum="7061AAA0C3CD1669" modified="2011-06-28" version="1">MVRGPIDQADWALMSPFTPHLRLHDRYVVRERIGLGGMSEVWRADDEVLGRSVAVKVLAAGFAADPDLRAAIRREARAAARLTHPNVTQVYDYGEAGLDGAIVPYLVMELVDGRNLADRLADGPLPWPSALRMAAQVAAALAAAHRIGVVHRDIKPGNVMLTETGAKVLDFGIAALAGPLAAGAGQAAVEPMMGTPAYTAPERLQAAAPNPASDVYALGVLLYRALTGDVPLPVGSWEDALVVHADRRPVPPPRVSGLPTDIAALVLACLDPDPVRRPTAGQLAARFRAATGPAGPSTAVLPIVTPPTGPAEPVTTVTAAAPGHPPTLVDRTGDWSAAVAGDVHRTVRSPHRPYGPEGPPGLLPPAASRPAPGRPGRRRPPVGVLVAAVLVLLVGFGVLLAPGGDDGQSTAAPASTPAVPPTSATPTAKRPSPSPTPSAPVNLREFATEFIALLTEAQLTDGLDGKVADRLRKDLAKLAAGRAKDRQKRIEDLRERIEKETEQGRVPADFAERMDELLDRVEAALPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHA9</accession>
    <name>F4FHA9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAP transporter solute receptor TAXI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13875"/>
    <dbReference type="EnsemblBacteria" id="AEB43887">
        <property type="protein sequence ID" value="AEB43887"/>
        <property type="gene ID" value="VAB18032_13875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13875"/>
    <dbReference type="eggNOG" id="COG2358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033215_0_0_11"/>
    <dbReference type="OMA" id="PNYLIVR"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307901" evidence="1">
        <location>
            <begin position="39"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="324" mass="34814" checksum="44D81DD661CB353F" modified="2011-06-28" version="1">MLPVTRTRFAARDRRPVASAVVLVAVLLVLPSSLSACRDDPDDTVRIRIATGSPTAVYHAFGTSLATILNRELPNVHAEVLVTAASVENVRLLKAGEVELGFTQADVLPAYPGPDPPVVAVARVYDDLLHLVTTAASPIRKLTDLAGRRVSIGAAGSGTEITVNRLLTVAGLDDAGLHRVQLGLDDSVSALRRGEIDAFFFSGGLPVRAVAQFVEDTPARIVDLGEWTVPLRRGNREVYVPRDIPRSVYGMDPVTAVANPNYLLVRADLPEDLVRQVTRLLMERRAELAEAHPAAGRISARSAIATPPLPLHPGAAEYYRDSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHB2</accession>
    <name>F4FHB2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732557.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13890"/>
    <dbReference type="EnsemblBacteria" id="AEB43890">
        <property type="protein sequence ID" value="AEB43890"/>
        <property type="gene ID" value="VAB18032_13890"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13890"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507895_0_0_11"/>
    <dbReference type="OMA" id="NRYPAYW"/>
    <dbReference type="OrthoDB" id="1406172at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="541" mass="57814" checksum="36C3AACA3A99AD01" modified="2011-06-28" version="1">MPQAESRAERRRGRWQPRLDRPALVALILGVLGVGYRLYLVLHTVPVANSDEATFGLAALHIAQGREHPVFLYGQRYMGMLQSYLAAPLLAVTGPSWPALRLPVLALYALFLWLIHRLTRRIGSPWFATTIVGLLALGSERVIRDQVTTVGGRPEVKVAVLVMLLIVVGLARGTVRHRRWAVGGFGLLAGLALWSDWLIAPYLAVAGAALLWVLRRELLGGAGLLLLVGFGVGIAPMIRDNLVAPAGQDSLSVLGRISGAQGPSPTWGQRLDGGLLEGVPLAAGLCPMTGCAGWQEWFGLLYPVLLVVAAVLAGLAYRRRVGQGERVVAVVHLALLVGAAATLLAYVRSSLAATDPLGNARYLSVLQLSLPAVLWPLWVAAVACARGTVGAAGRLVGALATALLAALAATSLVVTVLFATVGAAPGRVQERQSRQLADTVRAAGLREVYGEYWTCNRLVFNTGEQVVCGVLDGDLHPGQNRYPAYWWRLARATRPGYVLEAGGSADRRLRELLGDGADAALLAEVGGFRVYHPPTPLRPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHB5</accession>
    <name>F4FHB5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="6" type="ordered locus">VAB18032_13905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732560.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13905"/>
    <dbReference type="EnsemblBacteria" id="AEB43893">
        <property type="protein sequence ID" value="AEB43893"/>
        <property type="gene ID" value="VAB18032_13905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13905"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015798_0_0_11"/>
    <dbReference type="OMA" id="RPNFWPN"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="5">
        <location>
            <begin position="196"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="522"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB43893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="681" mass="75770" checksum="8104DBDB6778A558" modified="2011-06-28" version="1">MTGRFPIEDVSPVVSCGRYPARAVVGELVPVSATAYREGHDALGCNVVWLGPDGRARPFTRMRPGEPGRDRWHATITPDAVGEWIFTVEAFSDPYLTWHNAVTKKIAAGQSAEDLTNDLAEGVRVLTAAADLVPAAQRARIEQAVAALADSTLPLPQRSAPALTLADLLWAHPVRELVTTGEEYRIWVDRERALYSAWYEFFPRSEGAILATTETPARSGTFATATERLPGVTAMGFDVLYLPPIHPIGRVNRKGPNNSLTAGPEDVGSPWAIGAAEGGHDAIHPDLGTPQDFRDFVAAAAEHGLEVAMDLALQCAPDHPWVTEHPEWFTTRADGSIAYAENPPKKYQDIYPLNFDNDPDGIRTEILRVVRHWVGEGVKIFRVDNPHTKPVDFWHWLIWEVKRTDPDVLFLAEAFTRPAMMHGLAKVGFTQSYTYFTWRTSPTEMREYCAELVAAADYMRPNFWPNTPDILHESLQHGGPPMFKIRAVLAALLSPSWGMYAGFELFEHVARPGAEEYLDNEKYELRPRDWAQAQAQGRSLAPFIATLNRVRRENPALHRLRNLVFHDIDNPALLCWSKHDPVTGNTVLVVCSFDSHTVQWGNTTLDMPALGLDWHDRFTVYDELTGAGYDWGQRNAVRLDPYLQPAHVFTLRRPATTVPATAAGPRGGTASATKDDARWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHB6</accession>
    <name>F4FHB6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_13910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732561.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13910"/>
    <dbReference type="EnsemblBacteria" id="AEB43894">
        <property type="protein sequence ID" value="AEB43894"/>
        <property type="gene ID" value="VAB18032_13910"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13910"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OMA" id="FRADDWP"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="29714" checksum="CF00D3E5ED008243" modified="2011-06-28" version="1">MGTYAVTGAASGMGRAAAERLRRDGHTVVGVDLRDVEVIADLSTPTGRAAAATEVLERAGGRLDGAVCAAGLGGIPGRDRLVQQVNFFGVVELLEAWRPTLAAAGNSKVVVFGSNSVTLTPMVPERAVRALLDRDADRALRVVGRFGKRSAPFAYASSKLAVTRWARHAAISPEWAGAGIRVNVLAPGIIATPLLEEQMARGEREAVEGLPVPIGGRGKPADVGEWVAFMLSPAADFLCGSVIFLDGGSDAYFRTDDWPVSTGPVGVLRYLRRAKAWRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHF9</accession>
    <name>F4FHF9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733786.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20155"/>
    <dbReference type="EnsemblBacteria" id="AEB45131">
        <property type="protein sequence ID" value="AEB45131"/>
        <property type="gene ID" value="VAB18032_20155"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20155"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_9_0_11"/>
    <dbReference type="OMA" id="FPVKYGY"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="34204" checksum="0F910FBE1286615F" modified="2011-06-28" version="1">MTRPARAFWLRAPGAGEIRPVTLPEPGADELQVRTLFSGVSRGTETLVFAGKVPDSQYATMRAPFQEGDFPAPVKYGYLNVGEVEQGPAHLRGRTVFCLYPHQSAYVVPVDAVTVVPEQVPASRAVLAGTVETAVNALWDAPPLLGDRVSVVGAGMVGCAVAALLARFPGVAVELVDTDPTRAEVAAALGVDFATPEAATGGRDLVVHASASAAGLQRGLDLLAPEGTVLELSWYGDRQVQLSLGAAFHSGRLTIRSSQVGMVAPARRSSRGYADRMALALHLLADPVFDTLITGRSAFAELPDVLARLSAGSLPALCHLITYDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHN3</accession>
    <name>F4FHN3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Abc transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_26636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26636"/>
    <dbReference type="EnsemblBacteria" id="AEB46402">
        <property type="protein sequence ID" value="AEB46402"/>
        <property type="gene ID" value="VAB18032_26636"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26636"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="HESFDGA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="342"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB46402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="614" mass="64848" checksum="F130613DB971B2CA" modified="2011-06-28" version="1">MLGRGLGVLGRAIREQPRIFAVAVSGSVLFGAMVVASAFVVGRVVGDVVVPAIERGSVGVSALAIAATALFGLSVLRVVGIFGRRLGAGYMQYRLQADYRRRVTRRYLDLPLSWHHRNATGTLLSNANSDVEAAWQPIAPLPFAVGTLVMLVGAVSSLFFTDWALALVGLAVFPALFALNVAYSRRMAPRQARAQRLRAEVSGIAHESFDGALVVKTMGRESQETARFADRTGQLRDALISVGRLRGIFDPMLETLPSLGTLAVLVVGAYRLRQGAIDVAELVSVAFLFTVLAFPVRAIGWVLAELPRSVAGWDRVSRVLDATGEMPYGEQRLAPTAAPASLTFTDVGFAYEPAEAHLPGAQVLGEVSFTVEPGRTVALVGPTGSGKSTIASLAVRLVDPLAGAVRIDGVDVRQLTADSLAANAALVAQVPFIFDDTIRANVSLDRPGIDDEVVWSALRLAEADGFVAALPDGLDTMVGERGTSLSGGQRQRLTLARALAGRPRLLVLDDATSAVDPRVEAAILAGLRSSATGGPGASILVVAYRRATIALADEVIYLEQGRVLARGTHSTLLATVPGYADLVTAYEQAEVDPESTAQDYDEVAPLPSGLEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI62</accession>
    <name>F4FI62_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_30314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AB-18-032</strain>
            <plasmid evidence="2 3">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB48026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713148.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30314"/>
    <dbReference type="EnsemblBacteria" id="AEB48026">
        <property type="protein sequence ID" value="AEB48026"/>
        <property type="gene ID" value="VAB18032_30314"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30314"/>
    <dbReference type="eggNOG" id="ENOG503049P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157925_1_0_11"/>
    <dbReference type="OMA" id="AKMAISH"/>
    <dbReference type="OrthoDB" id="1862416at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB48026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="9937" checksum="981EA531D0C2840C" modified="2011-06-28" version="1">MTLIGGLAHAESILAQTVPNPGGGVAPPGVAGSGVLLILQWIAWLAVAACVAGMLYTAAKMAISHRRGDDTNVSQLGWVFAACVLIGSASAIVGALIGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F153</accession>
    <name>F4F153_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07945"/>
    <dbReference type="EnsemblBacteria" id="AEB42707">
        <property type="protein sequence ID" value="AEB42707"/>
        <property type="gene ID" value="VAB18032_07945"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07945"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_11"/>
    <dbReference type="OMA" id="ACEDIGE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="12"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="258" mass="27087" checksum="821378013585F1A3" modified="2011-06-28" version="1">MTRGRPGHPLPPDTDVVRADFDDPDSLRRALTGVHSVFLLTAPAAPTPDHDLALLAAARSAHVTSVVKLSAIGTGERFGTVTVGAWHQAAEDAVRASGMAWTVLRPSSFASNFLHWASLIRAGQPVPNLTGEGKQGIIDPRDIAAVAVAALTDPAHAGMTYTLTGPEPLHVPDQATRLAQVIGRPVDTTDLPPAVARQQLLASGMPSAAVEATIIGSAWARAGHNAVVTDDVEKVLGRAPATFLSWAQRHREAFIGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4F158</accession>
    <name>F4F158_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_07970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731385.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07970"/>
    <dbReference type="EnsemblBacteria" id="AEB42712">
        <property type="protein sequence ID" value="AEB42712"/>
        <property type="gene ID" value="VAB18032_07970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07970"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_888372_0_0_11"/>
    <dbReference type="OMA" id="DTYGCQS"/>
    <dbReference type="OrthoDB" id="1468733at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006991386" description="Serine protease" evidence="3">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="313" mass="32335" checksum="884A262A55ED5DCE" modified="2011-06-28" version="1">MALAAVAFGAAAPPAGPAVAASNRDRVASGDAASSGHRAVSIMVTPSGDTAAGTTPTAGVTAIFGPDNRVPVRTTTTYPASATVLLTFNDGQCTGFMISERTVATAGHCLHTGGRTGTWRTNIVAYPGHDGATAPFGSCTAVQLTVPQNWIIGPVNTPGPPDPAYDYGAVRLNCTIGTRTGWLGLGYTTQRLTGSCTTTHGYPAGRPGQWASKDFIRAEDANALYVQHAMTGGQEGSPIYYTPNPDDWCPTLPPLVNPCPCPPPPPDPCMCPDPYATALGILTNGPYGSGPGGTNNIALRITQPVINNLMQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F183</accession>
    <name>F4F183_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase/fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="9">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_14035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732586.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14035"/>
    <dbReference type="EnsemblBacteria" id="AEB43919">
        <property type="protein sequence ID" value="AEB43919"/>
        <property type="gene ID" value="VAB18032_14035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14035"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_3_11"/>
    <dbReference type="OMA" id="CPKGISL"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB43919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="252" mass="26826" checksum="045003B3D37D69B9" modified="2011-06-28" version="1">MNLTLRIWRQSGPADKGRMVTYQVEDVSPDMSFLEMLDVLNERLILAGEEPVAFDHDCREGICGMCGLMINGNAHGPQRGTTACQLHMRQFKDGDTIDIEPWRARAFPVIKDLVVNRNAFDKIIAAGGYITAPTGSAPEAHSVPVAKANADAAFESAACIGCGACVAACPNGSGMLFTAAKVTQLGLLPQGQPERYTRVIGMLDAHDEAGFGGCTNAGECTAVCPKGIPLTTIGRLNRDYLAATTTKRPDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F192</accession>
    <name>F4F192_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_14080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14080"/>
    <dbReference type="EnsemblBacteria" id="AEB43928">
        <property type="protein sequence ID" value="AEB43928"/>
        <property type="gene ID" value="VAB18032_14080"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14080"/>
    <dbReference type="eggNOG" id="ENOG5033ZA2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_522677_0_0_11"/>
    <dbReference type="OMA" id="RCNFESE"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309001" evidence="2">
        <location>
            <begin position="17"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="521" mass="53841" checksum="EB599253B1B9684F" modified="2011-06-28" version="1">MLATTALLGPVPVAHAADALPDLSVSFTREPVAEVDNSGTTVGMYVYNYGEADANAVTVTIDLSKLSDAVVATVPDWVDNCKLADKKITCDVGVLVAGQVDTLYPVSLASRQGAKPGDAGSVTVTIASTEGDANPDDDITTFPVTVVASGPDLVAAAADLNDKSDRVGPGDTVPLYSGVFNEGDTAATDFTFTVSLTTGATFVERYSDCTYADYYPDDVGAPYVYGPSEVTCVLPLTLEPGEGLLLFDDETGESVFNITFGRNLPGPGEHYGFVSVALAGESRAAKKVAGSKGTGPSFADAVKALQVKAADAKVARQSSTKWELDESDNYADFRFWSKKNTIDVAVTAPAVKGAVGETVDLTYEVVNHGPSDGGGPGVLITAPSGTVLLPAEWCYTDGEPGGTLPESKKLRCNFESEFPSIASGYGRIKATVQLKIKSTPGTDGTIVVDGAMYSTESKPENNTARIVIDNGDGDGGSGGGLPVTGAPAAAVAGVGAAVLALGVVLFVMFRRRRLAFQAPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1A3</accession>
    <name>F4F1A3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gabD1</name>
        <name evidence="3" type="ordered locus">VAB18032_14135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732606.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14135"/>
    <dbReference type="EnsemblBacteria" id="AEB43939">
        <property type="protein sequence ID" value="AEB43939"/>
        <property type="gene ID" value="VAB18032_14135"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14135"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_11"/>
    <dbReference type="OMA" id="KAMRWYA"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="2"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="470" mass="50170" checksum="7E52A4738E4A886A" modified="2011-06-28" version="1">MTIATTNPLTGQVLKTYEPMSDEQLRGAIERADLAYQQLRGTTIEQRGQWLTAAADLMEAERDDIGRLMTTEMGKTYAAAKAEVSKCAAACRFYAARAAEFLADAPADAAAVSATRAFVRYQPIGPVLAVMPWNFPLWQVVRFAAPALMAGNTGLLKHASNVPQTALLLEDVIRRAGFPEGAFTTLLVSSDAVEQILADPRVRAATLTGSEPAGRSIAQIAGRELKKTVLELGGSDPFVVMPSADVELAAEVATTARCQNNGQSCIAAKRFIVHTDVYEAFAEAFAHRMSALRVGDPMDADTDVGPLASERGRDEVDAQVRDAVDKGATVLCGGEKPTGEGWFYPPTVVTDLDQSMRMWAEEVFGPVAGLYRVSSYDEAIEVANGTAFGLGANAWTRDPQEQERFATDLVAGAVFINGMTTSYPELPFGGVKNSGYGRELSAQGMHEFCNVKTVWIGEGTAGVGAGAHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1D2</accession>
    <name>F4F1D2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14280"/>
    <dbReference type="EnsemblBacteria" id="AEB43968">
        <property type="protein sequence ID" value="AEB43968"/>
        <property type="gene ID" value="VAB18032_14280"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14280"/>
    <dbReference type="eggNOG" id="ENOG5031VK7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2385308_0_0_11"/>
    <dbReference type="OMA" id="AKFATDD"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="94" mass="10174" checksum="39BBEDC1817F636E" modified="2011-06-28" version="1">MHQGSGFLTTRQRRLAWIGFLLAAVQAPVSARLVADSSWLFSLCVALMVATVIIADDAARRRPLVRLTSPPTARLAGSSALCDRSPRPRVGFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1D4</accession>
    <name>F4F1D4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_14290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732637.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14290"/>
    <dbReference type="EnsemblBacteria" id="AEB43970">
        <property type="protein sequence ID" value="AEB43970"/>
        <property type="gene ID" value="VAB18032_14290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14290"/>
    <dbReference type="eggNOG" id="COG5637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079860_3_1_11"/>
    <dbReference type="OMA" id="NQIIQWE"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="17512" checksum="2E9576B94316E06B" modified="2011-06-28" version="1">MSGVTEHVDVAVPVRTAYDQWTQFEEFPHFMEGVESVRQLSDTMTHWTVEIAGVKREFDAEITEQLPDERVAWRSTGGTQHAGVVTFHRLDEHSSRVSLQLEFDPHGVIEQAGDKLGVVDRRAKGDLQRFKQFIERRGQETGAWRGKVDRPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1F3</accession>
    <name>F4F1F3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732656.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14385"/>
    <dbReference type="EnsemblBacteria" id="AEB43989">
        <property type="protein sequence ID" value="AEB43989"/>
        <property type="gene ID" value="VAB18032_14385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14385"/>
    <dbReference type="eggNOG" id="ENOG5032G8D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114869_0_0_11"/>
    <dbReference type="OMA" id="AGAYRHW"/>
    <dbReference type="OrthoDB" id="1718743at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="17154" checksum="678D8D604E9E4F67" modified="2011-06-28" version="1">MIEEPAYTGFGFTDEEWGLLVGLPQSVLTAASAAESDGTRATMAESAAGLESISAGRESASPLVAAVAGELVTRVGDPEAGEELPAIAPADPRAYAEDVLVRAKEAMALLAAKVDSGEAGAYRHWLVEIAERVVGAASSGGVLGLGGSQVSPSERRFRDRLAQVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1H2</accession>
    <name>F4F1H2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733855.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20505"/>
    <dbReference type="EnsemblBacteria" id="AEB45201">
        <property type="protein sequence ID" value="AEB45201"/>
        <property type="gene ID" value="VAB18032_20505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20505"/>
    <dbReference type="eggNOG" id="COG5516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087298_0_1_11"/>
    <dbReference type="OMA" id="TARWCSM"/>
    <dbReference type="OrthoDB" id="1478254at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="167" mass="19242" checksum="F23F02715B11CB9C" modified="2011-06-28" version="1">MIDEEALLEALNSTPVVDGRPQDRWADEDALRQWAREHGGADDAPAIEWLRTARDVLQVATRGPVPEADLRRILTGVQQVPEVDGSTLRWRLYGPPERMLAVELVLTWYDVQTRRPGRLRPCGNDECRLFHLDRSRANTARWCSMKTCGNRLKARRHQERTRHKPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1V3</accession>
    <name>F4F1V3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribokinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_27276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735178.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27276"/>
    <dbReference type="EnsemblBacteria" id="AEB46528">
        <property type="protein sequence ID" value="AEB46528"/>
        <property type="gene ID" value="VAB18032_27276"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27276"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_5_2_11"/>
    <dbReference type="OMA" id="SQQIARM"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="28"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="325" mass="35169" checksum="74EF2918355CC5FC" modified="2011-06-28" version="1">MKIAVTGSIATDHLMSFPGRFADQLIADQLHQVSLSFLVDDLVLRRGGVAANIAFGMGQLGLRPVLLGAVGADFADYRSWLERHGVDCDSVHVSEVAHTARFVCTTDTDMCQIASFYAGAMSEARNIELQPVAERLGGLDLVLVGANDPEAMLRHSAECRERGYPFAADPSQQLARMDGTDVVGLVDGADYLMTNDYEKSLLQSKAGLSDDQLLDRVKIRVTTLGKRGVEIVGRDIDPIHVPIAREAQAVDPTGVGDGFRAGFFTALSWGVGLERAAQVGSLLATLVLETVGTQEYQVRRDLFVKRLAESYGDEAADEIRPHLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1V8</accession>
    <name>F4F1V8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735183.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27301"/>
    <dbReference type="EnsemblBacteria" id="AEB46533">
        <property type="protein sequence ID" value="AEB46533"/>
        <property type="gene ID" value="VAB18032_27301"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27301"/>
    <dbReference type="eggNOG" id="ENOG5031D67">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091328_0_0_11"/>
    <dbReference type="OMA" id="LMRTLQM"/>
    <dbReference type="OrthoDB" id="1936227at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="200" mass="22193" checksum="5BAAAFCC94B4F24E" modified="2011-06-28" version="1">MPSLFRRKSADLADPATEPLTPAEEEAEANRPRGYTPSKGRETPKRPTSGRRPPGTTKPLSKEEAKALRRQRRAEAAAEFRREGGPRDRGPERLLARNVVDARRTVGTWFFGGALIVLIGSNQAMPPAVRLASNLLWGALAIGVVIDSVLISRKIKKLVRTRFPQSTQRMGSLYLYAIMRAITFRKLRTPEPKVTIGDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1Y8</accession>
    <name>F4F1Y8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_03255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736367.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03255"/>
    <dbReference type="EnsemblBacteria" id="AEB47735">
        <property type="protein sequence ID" value="AEB47735"/>
        <property type="gene ID" value="VAB18032_03255"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03255"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_4_11"/>
    <dbReference type="OMA" id="NWTVEWY"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="196" mass="21809" checksum="7EA22D00211A31B5" modified="2011-06-28" version="1">MRTRSEDTRARILTASADLFARQGYHGTGLAELLDAVGLQKGGFYHHIASKEELLLEIMLDPIDRILVSSDQILATDGDATTKLRQLGTDLGNAMAADLAAWTVFLREYSVLGADGKAQILQRRQQYLDRWRQVLQEGATAGEFRPLDLAFVEGILGLFIYTFVWARASTPPEELTRSIMQVLMPGICLHPVPQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F226</accession>
    <name>F4F226_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_03445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03445"/>
    <dbReference type="EnsemblBacteria" id="AEB47773">
        <property type="protein sequence ID" value="AEB47773"/>
        <property type="gene ID" value="VAB18032_03445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03445"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054185_0_0_11"/>
    <dbReference type="OMA" id="LLVKHYF"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="454" mass="46122" checksum="DDAB3735099C5E8D" modified="2011-06-28" version="1">MTQTTGSDTSRVRLGAAGAAVTLATLVTNALAYVVPVLGARRLSAADLGALATVLALAAIAAVPGFGLQIAVAAHRARSGGDGAGRLGLRTAALTGAVTLALAPLLTVLLRLPAPLTLLLATTTFATVMAGRWLGELQGDQRFLRLAVAMAVLAAGRYGGLVVGLLLGRGPATCLLLTTVTGLLALPLLARLASPTTTATATPGAVPTGSRDDQPRSAEPGDPVPRRLGARQVTTACAATLAMLAISYADLILARQLLPAADSGAYAVGSVLTKGALWAPQVVTLLVLPRLARGDRRARLVALALITTCGAALVATAAIGGELAFRLAGGADYLHLADTAPIFAATGALYAVVFMLVNDRVATGARWPAAPLWMATVGLTVCAALIAPRTVTGVLSCALVTAAVTAATMSWLVFRPSHPRTTQRDRTAAPTPQTGVDGDSPHTQTPRTPSRWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F238</accession>
    <name>F4F238_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">VAB18032_03505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736417.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03505"/>
    <dbReference type="EnsemblBacteria" id="AEB47785">
        <property type="protein sequence ID" value="AEB47785"/>
        <property type="gene ID" value="VAB18032_03505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03505"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036302_1_1_11"/>
    <dbReference type="OMA" id="AANPTTC"/>
    <dbReference type="OrthoDB" id="311112at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB47785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="475" mass="50314" checksum="903FC4C1CB172EAB" modified="2011-06-28" version="1">MPSRRDQVQSYQFFVQRMTSALVAREPDPEAAPFRRLGGAGFASVMVAVLCLAAVGVYGLLRPGGATKWKDGAGVILEKETGTRYLYREGRLHPVVNYASALLAMESAAPTVSVSRNSLVGTPRGPRIGIPDAPDALPAPGRILDGPWTLCTQPARDAAGGVVATTVLTVGRAPVGGREPGDAALLVRDRKTKRLHLVWRDHRYEIRNEKVVLEGLVMTAEPVVEVGGAWLNALPAGEPITPRRVTDRGAASTALPDARVGQVYVVKSQNGSRQYYIVERERLVPITPVEADVLLADGETQAAYPDGTKPAPIDLAAGTAAAAPKASAPQQGRHRAPEQRPDIARLSGSDPAVCAAYQPDQDEPTVLLDAQVEPVREPVRTREQTGSGIPLADRVVIEPGYGVLVAALSSPDQDGGTLNLVTDLGYRYPLASEGVPAMLGYSGLRPIRLPASLVVRLPAGPALDPTTAKQAIDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F296</accession>
    <name>F4F296_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metXA</name>
        <name evidence="5" type="ordered locus">VAB18032_08335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731456.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08335"/>
    <dbReference type="EnsemblBacteria" id="AEB42785">
        <property type="protein sequence ID" value="AEB42785"/>
        <property type="gene ID" value="VAB18032_08335"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08335"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_1_2_11"/>
    <dbReference type="OMA" id="TRFCVVS"/>
    <dbReference type="OrthoDB" id="536745at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2 3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB42785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="410" mass="44542" checksum="965A0ABC9C8C9BD8" modified="2011-06-28" version="1">MAAATLSAGSVGSVETQHLDLPAPLPLDCGRELYPVRVAYETYGTLSPQRDNVILVCHALSGDAHAAGFAKTPPAASTRDGFGAEGRDRPADKGLGWWDGMIGPGKAFDTDRYFVVATNLIGGCRGTTGPSSTDPATGRPYGSDFPVLTVADMVRCQRAFLDVLGIERLAAVAGGSLGGMQALEWAVRYPDQVDAIVVIASTHALHPQGVAWNAIARESIMRDPAWQDGHYYGTGRAPEAGMGVARMLGHITYLSAPALTDRFGRRLQFADNIRYTFRDPEFEVESYLQHQAASFVRRFDANTYLYLSRALTYFDLAREHGAGSLRRALAGVSARTLLIAFSSDWLYPPAASAEIEEALHSLGKPVEFHLIEAPYGHDSFLLEEAQQTPIVRRFLAEQCAGERRRATRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2F8</accession>
    <name>F4F2F8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_14590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14590"/>
    <dbReference type="EnsemblBacteria" id="AEB44030">
        <property type="protein sequence ID" value="AEB44030"/>
        <property type="gene ID" value="VAB18032_14590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14590"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_17_1_11"/>
    <dbReference type="OMA" id="VEAWMKV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="62" mass="7141" checksum="6DBCA3093E5F398B" modified="2011-06-28" version="1">MELVGVSEIREMLGNVSRQRASVIANQRNFPEPIAVLAMGKVWRKSDVEAWIREYRPELAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2M3</accession>
    <name>F4F2M3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_20940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733942.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20940"/>
    <dbReference type="EnsemblBacteria" id="AEB45288">
        <property type="protein sequence ID" value="AEB45288"/>
        <property type="gene ID" value="VAB18032_20940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20940"/>
    <dbReference type="eggNOG" id="ENOG50321JS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2618095_0_0_11"/>
    <dbReference type="OMA" id="GPRFCAQ"/>
    <dbReference type="OrthoDB" id="1962154at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="78" mass="8681" checksum="17D2AC32B5AD1E80" modified="2011-06-28" version="1">MQQVQLSDVEVRVYDAVAALEARGQVPYPDSIAQECGLTEEQLQTPLHLLTEKNLLHREDSPMAGLDFGPRFCAQQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4F348</accession>
    <name>F4F348_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">VAB18032_03725</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736459.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03725"/>
    <dbReference type="EnsemblBacteria" id="AEB47827">
        <property type="protein sequence ID" value="AEB47827"/>
        <property type="gene ID" value="VAB18032_03725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03725"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026437_2_1_11"/>
    <dbReference type="OMA" id="GARYRCE"/>
    <dbReference type="OrthoDB" id="1834577at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="15">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="138"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AEB47827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="41453" checksum="5564656CA532B148" modified="2011-06-28" version="1">MDNFARLLKESWALVEADRVRLSEHFYARLFLLDPELRKLFPVQMAGQGDRLLEAIIAAIHTVDDPEGFDEFLRALGRDHRKYHVEAANYDTMGVALLDALRSTAGDGWNLEYDQAWRDAYAAISEKMLAGAAADDNPPFWHAEVLTHERYGPDTAVFTCRALQHPLTWKAGQYVSIEAPRYHPRVWRTYSVANAPNDDNVLEFHVRTPEGAGWVSGALVRRVKPGDLLRVAAPMGSMTLDRSSDRDVLCVAGGVGLAPIKALVEELVSFNRTRWVHLFYGARTESDLYGLDGLRDLVAAHPWLSVTAACSDDPDFDGEHGDISDVVARYGPWTTHDCYVSGSAAMVRSTLRVLAADDVPPQHTRYDTFGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3C6</accession>
    <name>F4F3C6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/lc7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731521.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08660"/>
    <dbReference type="EnsemblBacteria" id="AEB42850">
        <property type="protein sequence ID" value="AEB42850"/>
        <property type="gene ID" value="VAB18032_08660"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08660"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_0_1_11"/>
    <dbReference type="OMA" id="SDGFPRD"/>
    <dbReference type="OrthoDB" id="1635683at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="134" mass="13845" checksum="BAA2592613EC0EE9" modified="2011-06-28" version="1">MTSTQDLGWLLANFADRVPGVAHAVAVSADGLLLASSRDLPRDRADQLAAIASGLVSLTQGAARCFEGGAVLQTVVEMDNGFLFLMSISDGSSFAVLAARSCDVGQVGYEMALLVDRVGDALTPQPRTAVGMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3P9</accession>
    <name>F4F3P9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_21250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734004.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21250"/>
    <dbReference type="EnsemblBacteria" id="AEB45350">
        <property type="protein sequence ID" value="AEB45350"/>
        <property type="gene ID" value="VAB18032_21250"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21250"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125326_1_1_11"/>
    <dbReference type="OMA" id="MWADEAA"/>
    <dbReference type="OrthoDB" id="1969833at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="131" mass="14308" checksum="AD7CAC920DB768E5" modified="2011-06-28" version="1">MWADEAALDATQRRLDEWEASLADRAQRAQALSARVSTLTGTAHNIDRSVEVTVDSAGHLVDLRLDERIRQQSAAHTARQVLATTRAAQADLLRRITTATTETLGDDDPAGPALLDSYRRMTGQDAPDADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3R3</accession>
    <name>F4F3R3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_01470</name>
        <name evidence="2" type="ordered locus">VAB18032_15555</name>
        <name evidence="3" type="ordered locus">VAB18032_21320</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01470"/>
    <dbReference type="EnsemblBacteria" id="AEB44223">
        <property type="protein sequence ID" value="AEB44223"/>
        <property type="gene ID" value="VAB18032_15555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB45364">
        <property type="protein sequence ID" value="AEB45364"/>
        <property type="gene ID" value="VAB18032_21320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47378">
        <property type="protein sequence ID" value="AEB47378"/>
        <property type="gene ID" value="VAB18032_01470"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01470"/>
    <dbReference type="KEGG" id="vma:VAB18032_15555"/>
    <dbReference type="KEGG" id="vma:VAB18032_21320"/>
    <dbReference type="eggNOG" id="COG5659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033141_0_0_11"/>
    <dbReference type="OMA" id="RRWTSWH"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="1">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="383" mass="42889" checksum="1A60BA4699C0687C" modified="2011-06-28" version="1">MERKTCWSLAERAGHDDPQAMQRLLRTAVWDADSVRDDVRAWLIEQLGHPDAVLACDETGFLKKGLSSVGVQRQYTGTAGRIENSQVGVFLAYIAPHGRAMIDRRLYLPETTWCQQPDRLTAAGVPDQVGFATKPALARQMIAAALDAGVPFGWVTGDEVYGADPGLRADLEHRGIGYVLAVGCDRRVDVNDGRTLIRVDDLAARIPSREWQQHSCGPGAKGPREYLWAWITTATSPGEHRCLLIRRNRSTGELAFYLCWSPRPAPLHTLVTVAGSRWSIEELFQTGKGQVGLDHYQVRGWTGWHRHITLAMLALAVLTILAARQPDTDPEIIPLTVAEIRHLFNAFVLAVTLPPEHILHWSVWRRTSQARARRSHYQRRQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3V2</accession>
    <name>F4F3V2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase SNF2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_21515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734056.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21515"/>
    <dbReference type="EnsemblBacteria" id="AEB45403">
        <property type="protein sequence ID" value="AEB45403"/>
        <property type="gene ID" value="VAB18032_21515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21515"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307750_0_0_11"/>
    <dbReference type="OMA" id="IHYDIPW"/>
    <dbReference type="OrthoDB" id="291634at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="121"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="422"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="939" mass="105324" checksum="8C5B2A18978603DB" modified="2011-06-28" version="1">MTTAQEATFAPGSRIIVRDEEWLVRSVKTGTADGTMIKAVGVSEFVQDVEATFFTALDAIAPMRPEETQLVRDTSSRFRQSRLFLEAVLRRTPLPRTERGLALADRFLLDPLTYQQRPVELALSGLRPRILLADVVGLGKTLEIGLILAELIRRGRGDRILVVSPQQVLEQFQRELWTRFAIPLVRLDSTGIQRIQQEIPAGRNPFTHFKRAIISVDTLKDAGQFGHHLDATTWDAVVIDESHNLINKGTKRNELARRLAAKTDALLLASATPHNGDKESFAQLISLLDPAAIANPKDYQASDIAHLYLRRTKISPEVRDQIGDRWADRGPSQPLHCQATPIEEQIFDELTDVWLAGKWSDEAVTGQHRLFPYTLLKSFLSSHRALHETVTNRSKKATGTERAALYRLAELTSAMTDSDSSKLRRLVEELKEIGVGKGSDTRAVVFSERVPTIKWLADTVPGLLGLKPDAVRVLHGGVADSDEQQILQEFELAGSGVRLLFTGDVASEGVNLHQQCHHLIHYDIPWSLIRIEQRNGRIDRYGQRHQPQFRALLLTSAREDAKDDRTVSEVLLRREETAHRTLGSVEAATGHYDAKAEEDRLVRDLLHGKTVDESYAQAHTEIDVLADLFGDVGSAPVVEEVPQARVPKLFDSTRDFVDAALHEIYDDRPEDRIDLRREDELLTFRAPDDLVYRLTDLPRSYLRTHREGEDLRLKVTFDRRLAQRKLDQARQSKTPMWPEIAFLSDVHPMVDWLVDKVLIRLGRQQAPVLTADVSTPTFLIQGVYANRLGQPTVVQWMAVAGLPTEPTIAPMDEVLRSAGVGPDMVNRAETIDTGALTALLPRAVAAARDQLEDKRAEFDAANAEPLRRHRERLVTFQQASLVDELPGAHRERRRQRVDATVAEQHDLLDRLETDGEPLLRVLAVLVPSPESAPEHGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3W0</accession>
    <name>F4F3W0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Radical SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_21555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_21555"/>
    <dbReference type="EnsemblBacteria" id="AEB45411">
        <property type="protein sequence ID" value="AEB45411"/>
        <property type="gene ID" value="VAB18032_21555"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_21555"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042889_0_0_11"/>
    <dbReference type="OMA" id="AHYFMPL"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023980">
        <property type="entry name" value="CHP04013_B12-bd/rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04013">
        <property type="entry name" value="B12_SAM_MJ_1487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="183"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB45411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="456" mass="49953" checksum="A2685378E3E2D2EF" modified="2011-06-28" version="1">MPVDITAGPPDTIAAMEAAELVLVLRYRKAVTYGLHVLLGALETHQTSTRYEVRFGDTPETTAAHIRDAATTATRVLVLWSFYSPDAHALAQELAEIRALADAPNVTHIAGGVHATAEPVQTLDAGWDIAAVGEGETTLLHLVDAVGDPAGITGLVYRDDTGAVVRTGRPQRRPLDDFRGFSLRWDRFNALEVTRGCVFSCRFCQTPFMFSAKFRHRSVANVRWHVDRMRARGLRDVRFITPTALSYGSQAEEPNLDAVEELLASCKEGIGPNGRVFFGSFPSEIRPEHVSRAALRLVKKYCANNNIIVGAQSGSDRVLDAAKRGHGVEEVKRAARLGIEEGFRINVDMIFGMPGESEQDVADSLRLAGELAEVGARIHAHTFMPLPGTPWRDAPPGDVDPETIRQVDRLSQRGALYGHWQKQREHAARLAAAAEAYPRPGRSRTILPQLPRGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3X4</accession>
    <name>F4F3X4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory P domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735270.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27736"/>
    <dbReference type="EnsemblBacteria" id="AEB46620">
        <property type="protein sequence ID" value="AEB46620"/>
        <property type="gene ID" value="VAB18032_27736"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27736"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031217_0_0_11"/>
    <dbReference type="OMA" id="TTREGND"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003313572" evidence="1">
        <location>
            <begin position="29"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="429" mass="46537" checksum="9FE584F17E8C633D" modified="2011-06-28" version="1">MRPVRIGLALAVGALVVSMLGPGSPSVAHDPATPAGRASAQEFMAQREPTQQMAAQAATACTNGQAAGYPCRNVDLLSFMPLSSIGGSQANDIWGWTDPQTRKEYALVGRRNGTSFVDVSNPSAPVYLGNLPAYQNRTAVWRDIKVYRDHAYVVADVSGHGMQVFDLTRLRGVTTPQTWTANAHYSGFGNSHNIAINEQTGYAYAVGTNTCSGGLHMIDIRTPKSPVSAGCVSNDGYTHDTQCVVYRGPDTAYSGREICVSSNEDTVTIVDVTSKSSPRQLARIGYTGRAYTHQGWFTEDQRYFLLDDELDESRRGVNTQTYIWDLADLDAPRHIGTYSAPSGVAATDHNQYVKGRYSYQANYRAGLRILDLTDVSSGRATEAGFFDIYPSSNSASMNGAWSVYPYYPSGIVVVSGIEQGLFVLQPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F456</accession>
    <name>F4F456_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_03935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03935"/>
    <dbReference type="EnsemblBacteria" id="AEB47869">
        <property type="protein sequence ID" value="AEB47869"/>
        <property type="gene ID" value="VAB18032_03935"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03935"/>
    <dbReference type="eggNOG" id="COG1213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_5_0_11"/>
    <dbReference type="OMA" id="AYSLWCA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="254" mass="27910" checksum="D3579DEC942FB604" modified="2011-06-28" version="1">MNAVKTETGTGMVGMVLAAGAGRRLRPYTDTLPKALVPVDGEITILDIALRNLAEVGLTDVVVVVGYAADAVRERQAELERRYGVTITLVHNDKAEEWNNAYSLWLARDWFARGVLLVNGDTVHPVSVEKTLLAERGPGVLLAIDNIKPLAEEEMKTTFDAAGQLTRITKLMDPAEAYGEYIGATLIEPQVAEPLADALEATWRRDPNLYYEDGYQEFADRGGEVRAAPIGDVSWVEVDNHADLARAREIACRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4Q1</accession>
    <name>F4F4Q1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_15405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732858.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15405"/>
    <dbReference type="EnsemblBacteria" id="AEB44193">
        <property type="protein sequence ID" value="AEB44193"/>
        <property type="gene ID" value="VAB18032_15405"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15405"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_11"/>
    <dbReference type="OMA" id="RQAATWP"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="186"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="377" mass="38807" checksum="27517E6BB8115A47" modified="2011-06-28" version="1">MGTPERTGTVVLLLASSTGGVGQHVRALTRGLTAAGLPVLVCGPAATQDQFDFEAAGARFAAVEIPASPAPGDARAVAVLRRVLADEQVRVVHAHGLRAALVAVLARPSAPLVVTWHNAVLTGGLRGRISRLVERIVARGARVTLGASADLVDRAVALGAPDARLAPVAAPVLPAPRRGRAAVRAEFAVAADQPLILSVGRLHPQKRYDVLIDAAARWRERTPPPVVVIAGSGPAYLPLAARISAVRAPITLLGHRTDVADLLAAADLAVVTSDWEARQLFAQEALRAGVPLVATAVGGLPELVGDAAVLVPPGDVDAVDAAVQSLLDDDAGRVEWGRRGAARAATWPTETDTVAQVVALYAELAAPDADASSTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4S7</accession>
    <name>F4F4S7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15535</name>
        <name evidence="3" type="ordered locus">VAB18032_15995</name>
        <name evidence="4" type="ordered locus">VAB18032_16725</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732883.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15535"/>
    <dbReference type="EnsemblBacteria" id="AEB44219">
        <property type="protein sequence ID" value="AEB44219"/>
        <property type="gene ID" value="VAB18032_15535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44309">
        <property type="protein sequence ID" value="AEB44309"/>
        <property type="gene ID" value="VAB18032_15995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44449">
        <property type="protein sequence ID" value="AEB44449"/>
        <property type="gene ID" value="VAB18032_16725"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15535"/>
    <dbReference type="KEGG" id="vma:VAB18032_15995"/>
    <dbReference type="KEGG" id="vma:VAB18032_16725"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_11"/>
    <dbReference type="OMA" id="DNAMAET"/>
    <dbReference type="OrthoDB" id="1637053at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="129"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="35431" checksum="DC79E4288AB254F6" modified="2011-06-28" version="1">MNRTDVYRFIDAEKTIYPVRLLCRLLGVGHSGFYDWLRQGRQRAVERKRHDQQRVEITRQAWSEHRGVYGARRLTAELHERGHRWNRKAVARLMRLAGIEGAHRRRRGKPRRKAASTSTAPDLVQRQFTAAAPNRLWVADISYLRTWEGFLYLAVVVDAYSRRVVGWAMADHLRTELILDAVGMAIQHRRPARDQLIHHSDRGTQYTSFEFGRTLRSCGVLASMGSVADCYDNAMAETFFATLKTELVYTRAWPSRHELEMEVFSYIEGFYNPRRRHSRLGNVSPDTYEKIHRESLTDIEVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F511</accession>
    <name>F4F511_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_22000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734153.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22000"/>
    <dbReference type="EnsemblBacteria" id="AEB45500">
        <property type="protein sequence ID" value="AEB45500"/>
        <property type="gene ID" value="VAB18032_22000"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22000"/>
    <dbReference type="eggNOG" id="COG3236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084247_1_0_11"/>
    <dbReference type="OMA" id="WMMAAKA"/>
    <dbReference type="OrthoDB" id="1726046at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="190" mass="21127" checksum="830A4A742F5F12F9" modified="2011-06-28" version="1">MVTSVHSVADLTAAMRSGARVKFLFFWGHQPQRDGSVGAGCLSQWWSAPFTIDGLRFATAEHYMMWRKATLFDDHATAARVLAAAHPHAAKMLGRQVTGFDQHVWEQHRYDIVLTGTVAKFDEHPALRTYLIGTGERVLVEASPLDRIWGIGLAADHPHATDPARWRGLNLLGFALMQARDILTGQETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F525</accession>
    <name>F4F525_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735357.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28181"/>
    <dbReference type="EnsemblBacteria" id="AEB46707">
        <property type="protein sequence ID" value="AEB46707"/>
        <property type="gene ID" value="VAB18032_28181"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28181"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107220_3_2_11"/>
    <dbReference type="OMA" id="HHVYEDS"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="138" mass="15092" checksum="47C24B3A90C5C194" modified="2011-06-28" version="1">MSATRQTVDTLLSRIVAGAAPEQVAELYADQVDWQVNWPSSEHLDVPWIRPRSTRADVADHHRTLAAATVPGQAEATVTGILVDGPDAVVFGQVAQTVRRTGKRFTARFALHLTVVDGRIVRHHVYEDSLAIEAACRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F531</accession>
    <name>F4F531_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735363.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28211"/>
    <dbReference type="EnsemblBacteria" id="AEB46713">
        <property type="protein sequence ID" value="AEB46713"/>
        <property type="gene ID" value="VAB18032_28211"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28211"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127577_1_1_11"/>
    <dbReference type="OMA" id="DPRHWCL"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="113" mass="12231" checksum="C5F7FE986A4D398A" modified="2011-06-28" version="1">MLVTNRFVVDDDGAQDFTERAHAALAALAARPGYLRGQLVRALDDPRHWCLVTEWESVGTYRRALGGFDVKVTAIPLLAESIDEPSAYETLASAAPDGDVVVVDSDRAAGPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5B8</accession>
    <name>F4F5B8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ddl</name>
        <name evidence="7" type="ordered locus">VAB18032_04420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04420"/>
    <dbReference type="EnsemblBacteria" id="AEB47966">
        <property type="protein sequence ID" value="AEB47966"/>
        <property type="gene ID" value="VAB18032_04420"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04420"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_1_0_11"/>
    <dbReference type="OMA" id="MQGLLEC"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="107"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="320" mass="33187" checksum="98FBC872FB4AA607" modified="2011-06-28" version="1">MSGPTADDLHVVVLAGGLSYERDVSLRSGRRVLDALRSVGVEAELRDADVALLPALAADPPDAVVIALHGATGEDGSLRGVLDLCGVPYVGCDARASRLAWDKPSAKAVLREAGIATPDWVALPHDRFSELGAVAVLDRIVDRLGLPLMVKPAQGGSGLGAAVVRDAAALPAAMVGCFAYDPTALVERYVSGMDVAVSVIDLGDGPQALPPVEIVPRNGVYDYAARYTAGRTTWHTPARLEPAVAEKVGEVALAAHTALGLRDLSRVDLIVDSAGLPHVLEVNVSPGMTETSLLPLAVQAAGLDFGRVIGSLVARAVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5C2</accession>
    <name>F4F5C2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gidB</name>
        <name evidence="2" type="synonym">rsmG</name>
        <name evidence="3" type="ordered locus">VAB18032_04440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736601.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04440"/>
    <dbReference type="EnsemblBacteria" id="AEB47970">
        <property type="protein sequence ID" value="AEB47970"/>
        <property type="gene ID" value="VAB18032_04440"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04440"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_5_0_11"/>
    <dbReference type="OMA" id="WDRHVLN"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="236" mass="24642" checksum="E4672AE03C70EB34" modified="2011-06-28" version="1">MALLPPELAEAAGRLFGARLDLAAAYAELLATDGVVRGLIGPREAPRIWDRHLLNCAVVGELIPTDATVIDVGSGAGLPGLVLAIARPDLQVTLLEPLARRTTFLTEAVDALGLEDSVQVLRGRAEEVAAGPDPVRGDVVTARAVAPLDRLAAWCLPLAAPGGRLLALKGASAADEIVEHAPAVHRLGGAEPVLHRCGEGIVEPPTVVVEIVRDRLVGPTPRGSAKKSRGSRSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Q7</accession>
    <name>F4F5Q7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732934.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15800"/>
    <dbReference type="EnsemblBacteria" id="AEB44270">
        <property type="protein sequence ID" value="AEB44270"/>
        <property type="gene ID" value="VAB18032_15800"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15800"/>
    <dbReference type="eggNOG" id="ENOG5032418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2936511_0_0_11"/>
    <dbReference type="OMA" id="PTWDNKG"/>
    <dbReference type="OrthoDB" id="2031695at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="60" mass="6711" checksum="3AE535AAB8DC0278" modified="2011-06-28" version="1">MTNALAVLVNAAPEQLARLGVDPQRSVASIDAAKFDNRPTWDNKGKFDSRPGWDNWNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5U3</accession>
    <name>F4F5U3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_15980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732970.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15980"/>
    <dbReference type="EnsemblBacteria" id="AEB44306">
        <property type="protein sequence ID" value="AEB44306"/>
        <property type="gene ID" value="VAB18032_15980"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15980"/>
    <dbReference type="HOGENOM" id="CLU_2811261_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="67" mass="7433" checksum="A0A2AAD1EDF1A5CB" modified="2011-06-28" version="1">MRRLTLCRHHGTLPACDRTATPPHGSAAPDNQRSDHTHDTITVRSTPRTAPYAHRRHTSTAPEAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4F671</accession>
    <name>F4F671_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-hydroxymuconic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_28761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735472.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28761"/>
    <dbReference type="EnsemblBacteria" id="AEB46823">
        <property type="protein sequence ID" value="AEB46823"/>
        <property type="gene ID" value="VAB18032_28761"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28761"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="OMA" id="VWVNRYS"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017628">
        <property type="entry name" value="OHmuconic_semiald_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03216">
        <property type="entry name" value="OH_muco_semi_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="24"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="493" mass="52111" checksum="670CF6EB8D5A67C3" modified="2011-06-28" version="1">MTGHAPDGPGLLRNFVGGEFVSAGERFTKRSPVTGEPVFEVVEASRSTVDDAVSAARAAQRGPWGRMGERERAEVLRRVADELERRFDDLVAAEVADTGKAISQARTLDIPRGAANFRAFAEIVATAPTESFTTVTPTGGRALNYAVRKPVGVVAVIVPWNLPLLLLTWKVAPALACGNAVVVKPSEETPASATLLAEVMAAAGVPDGVFNLVHGFGPDSAGEFLTRHPGVDAITFTGESSTGGAIMRAAADGVKAVSFELGGKNAGLVFADADLDAAVEGSVRSSFTNGGQVCLCTERIYVQRPVFEEFTARLAKRAEELAYGWPADEATVNMPLISHGHRDKVLGYYDLARTEGAQVLAGGAVPRFGDARDGGAYVQPTVLTGLGPQARTNTEEIFGPVVHVAPFDDEDEAYALANGTEYGLAAAVWTRDVGRAHRAGQRLDAGIVWVNTWFLRDLRTPFGGVKASGIGREGGVHSLDFYSELTNVCVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6E4</accession>
    <name>F4F6E4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731761.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09860"/>
    <dbReference type="EnsemblBacteria" id="AEB43090">
        <property type="protein sequence ID" value="AEB43090"/>
        <property type="gene ID" value="VAB18032_09860"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09860"/>
    <dbReference type="eggNOG" id="COG4867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408088_0_0_11"/>
    <dbReference type="OMA" id="QITIFRL"/>
    <dbReference type="OrthoDB" id="171570at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="460"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="650" mass="71769" checksum="A51DA242E258AF80" modified="2011-06-28" version="1">MAGNRFRYGQWHGGPDPLAPPYDVQAAVDQVGQEVLAGGSLRQALRDLLRRGLQGRGGLDELTARARRLRREMLRRGELDGAVTRARALLDQALAAERDELAGRQDEAARFAETELNNLPRSTAQAVRELSGYQWASDEARQLYQRILDGLRDDVLGQRFAGLRESAQLAADPAVQERLAEMMQDLNALLARHARAEDTTDAFAEFMRRHGEFFPERPGNVDELIELLARRAAAGQRLMNSLSERQRTELAELMRQSLGDRLAGELSALEQNLRSLRPDLRWARGERTQGGEPLSYGEATGVLDEVAELDDLLDQFGQAHPGATLDDIDVDAVARTLGRDAAAAVRQLREMERELRRQGWVSRDAEGLTLSPKALRRLGGTALRQVFAELTAGPRGHHDLRSAGAAGEVSGASRPWEYGDEQPLDVVRTLTRAVARAGPGVPVPLAVTDFEVVETERRASAAVALCVDLSYSMISQGRWGPMKQTALALAHLMATRFPQDALQIIGFGREAAPLRQQELAAVEPDMAQGTNLQHALRLAGRHLRRHPDAEPVVLVVTDGEPTAHLDPEDGEAVFCWPPLRETIEATIREVDRLGRYGATLNLFMLGDDPGLRRFVDAVARRSGGRVFTPDTEDLGEYVVSDYLRARRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6G5</accession>
    <name>F4F6G5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_09965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731782.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB43111">
        <property type="protein sequence ID" value="AEB43111"/>
        <property type="gene ID" value="VAB18032_09965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09965"/>
    <dbReference type="eggNOG" id="ENOG5031V7Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1089103_0_0_11"/>
    <dbReference type="OMA" id="LAWHEID"/>
    <dbReference type="OrthoDB" id="1886213at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="26426" checksum="C4C2393113F5CA31" modified="2011-06-28" version="1">MDVTQKRAWLVMAVGFFLFGLSMLVLTDEPGVLTVVGGVLLVAFNGWRLVTAVVRPFRFRIDADGLDVRVAGLRRTLAWHEIDAIVLCRPAATGPAPWLLLVPAAGVLDRPLTEPSPVDGRKGLLLLDLGTVRQSVDEVTAALIRFGGGRFVDGRQHRRPASETPSFTTALRGYDQRQIDELVGQGLEAFASGVPTQRSAVRAQIESARTDLAISLRGYDIAEVDDYLDRLSADLADEPGPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6J1</accession>
    <name>F4F6J1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS3/IS911 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07725</name>
        <name evidence="3" type="ordered locus">VAB18032_16065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07725"/>
    <dbReference type="EnsemblBacteria" id="AEB42665">
        <property type="protein sequence ID" value="AEB42665"/>
        <property type="gene ID" value="VAB18032_07725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44319">
        <property type="protein sequence ID" value="AEB44319"/>
        <property type="gene ID" value="VAB18032_16065"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07725"/>
    <dbReference type="KEGG" id="vma:VAB18032_16065"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_11"/>
    <dbReference type="OMA" id="ACPKRAG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="102" mass="11503" checksum="D1C81643322B27C6" modified="2011-06-28" version="1">MPKPYPREFRDDVVRVARDRDPGVTVEQIAKDFGVHPMTLFKWLRQADIDAGATPGTSSSESAELREARKRIRLLEQENEVLRRAAAYLSQAHLPGKGSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6M1</accession>
    <name>F4F6M1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated Cse3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_16215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733009.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16215"/>
    <dbReference type="EnsemblBacteria" id="AEB44349">
        <property type="protein sequence ID" value="AEB44349"/>
        <property type="gene ID" value="VAB18032_16215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16215"/>
    <dbReference type="eggNOG" id="ENOG5030BEK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080982_0_1_11"/>
    <dbReference type="OMA" id="EQAGWPT"/>
    <dbReference type="OrthoDB" id="944950at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01101">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01907">
        <property type="entry name" value="casE_Cse3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="225" mass="25103" checksum="6E689DFF05E1C9EC" modified="2011-06-28" version="1">MFLTRFQINAARRNARKLLSSPHAMHAAVRAAFADAADYERPGVRTLWRLDTPATATVHLYIASPGRPDLTHLVEQAGWPTSEEAWTTREYDGLLASLRAGQEWAFRLTANPTHSGRKTAEAKETQRFGYLREHEQIAWLLARAERHGFTLATQQDGRPNLRLHRRQTQSFKRGMGTVTLTTATYDGILHVTDAHTLRRALTGGIGHAKAYGCGLLTLAPVQGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6P0</accession>
    <name>F4F6P0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_16310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733028.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44368">
        <property type="protein sequence ID" value="AEB44368"/>
        <property type="gene ID" value="VAB18032_16310"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16310"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_0_11"/>
    <dbReference type="OMA" id="KWIDQAG"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="170" mass="18450" checksum="48BC80FDC4382A9D" modified="2011-06-28" version="1">MHDTTTLAGRPSSASHLTLSQIMDQHHTNLMGTVHGGRILNLIDSVAGVVAARHSDGPAVTAAIDETAFLRAVRVGDVVHVDARITWAGRSSMEVAVKVTADRWDRAVPPTDVATAHLVMVAIDDDGHPRAVPPLLPETDGDRRRYREAQIRREHRLALRRALLDGAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4F6T2</accession>
    <name>F4F6T2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="7" type="ordered locus">VAB18032_22535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22535"/>
    <dbReference type="EnsemblBacteria" id="AEB45607">
        <property type="protein sequence ID" value="AEB45607"/>
        <property type="gene ID" value="VAB18032_22535"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22535"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072144_1_0_11"/>
    <dbReference type="OMA" id="VDLTIYV"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="6">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="251" mass="26140" checksum="DE05D0C6353F3681" modified="2011-06-28" version="1">MRPDITHDESVPHTHPEPGVDPHAPLPTAVRALRVGIGGPVGSGKTALVAALCRAFADELRLGVVTNDIYTTEDADFLKRAGVLDPARIRAVETGCCPHTAIRDDIGANLDAVDELAEALGPLDLVLVESGGDNLTATFSRGLVDRQIFVVDVAGGDKVPRKGGPGVTAADLLVINKTDLAPMVGADLSVMDRDARARRGSLPTVFQSITEDPLATQVAAWIRHELAHHRATGLESGPSAGTRAAVPAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F781</accession>
    <name>F4F781_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_10105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10105"/>
    <dbReference type="EnsemblBacteria" id="AEB43139">
        <property type="protein sequence ID" value="AEB43139"/>
        <property type="gene ID" value="VAB18032_10105"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10105"/>
    <dbReference type="eggNOG" id="ENOG5031HBQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1389704_0_0_11"/>
    <dbReference type="OMA" id="PARSAWN"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043760">
        <property type="entry name" value="DUF5706"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18967">
        <property type="entry name" value="DUF5706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB43139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="196" mass="21853" checksum="55604D29B0860787" modified="2011-06-28" version="1">MVRPGFVRQLPKPQRRRQSSGPQVGQTAQLHRRNTGQAAAVRLTERLLAEAREELRRADAKAVQWLSLFGGALLALVTVLVGVSWSPRHLTGTVAWTWWSGVLCGAAALLSLIMALLPRPNGDQELQLVAYFGHVHKLRDPVLVQRYVERVAHDTLPSLIYQLCWISRLAMTKYRWTRAGTVFSMLAAALIAVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7K3</accession>
    <name>F4F7K3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_16690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_16690"/>
    <dbReference type="EnsemblBacteria" id="AEB44442">
        <property type="protein sequence ID" value="AEB44442"/>
        <property type="gene ID" value="VAB18032_16690"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_16690"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043007_0_1_11"/>
    <dbReference type="OMA" id="DVVWLGW"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309144" evidence="2">
        <location>
            <begin position="37"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="326" mass="34670" checksum="8653D2428EF30697" modified="2011-06-28" version="1">MTARQPRGSIRTTITIARCALATALLVATTQTPVRAEQPTPDLNQSLAADQPLATGRAELSAGHVDIGPRYVGDQWTLLIHDGTQAQPVWRNPDETVLRVTDAALQTVPDDPAYAFLGVDAGTKVYVVPQVQSPDVVWLGWNTQDPRVMQSIDRGVTLTVRGVRGPGSLTTYLQSGNFAPPQPLWRSTEPKAQPFWAEVNTHTHANWVFTAPGVYLIAVQVSADLIGGETVTATRTLRFAVGDAASADEAYAATADTLVPAGQASAAGERAEAGEPADDSQRLLLAALLAMAALLASGLVLLLVRGRRAKRQVERERATLSSGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7T2</accession>
    <name>F4F7T2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LmbE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_23095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734371.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23095"/>
    <dbReference type="EnsemblBacteria" id="AEB45719">
        <property type="protein sequence ID" value="AEB45719"/>
        <property type="gene ID" value="VAB18032_23095"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23095"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_3_2_11"/>
    <dbReference type="OMA" id="NHRDTWG"/>
    <dbReference type="OrthoDB" id="1282433at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="248" mass="27121" checksum="97EE79954FBDBB61" modified="2011-06-28" version="1">MTEALEPLEPVTEDWQRALAIVAHPDDLEFGAAAAVARWTGQGKQVVYCLVTSGEAGIDGMPPARARQVREQEQRDSAALVGVDTVDFLGLPDGILEYGVALRRELAAVVRRHRPDIVITNNFRETWDGGLTLNQADHIAVGRATLDAVRDAGNRWIFPEQLIDGVEPWNGVRQVWAASSPRSKHGVDTTETFDKGVASLLAHEAYLTGLGDGSFDAQEFLEGGARLVGTRLGVRYGTSFEVFHFDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7T6</accession>
    <name>F4F7T6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734375.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23115"/>
    <dbReference type="EnsemblBacteria" id="AEB45723">
        <property type="protein sequence ID" value="AEB45723"/>
        <property type="gene ID" value="VAB18032_23115"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23115"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114078_0_0_11"/>
    <dbReference type="OMA" id="HWFPFDL"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="22985" checksum="F2513B91D0DC74C7" modified="2011-06-28" version="1">MRVRPISPQRLVTELAQRLADTRSAGRLRVAVDGPAAAHPDELAAALVDPLRAYGRPARHIRSDDFLRPASVRLERGRTNPDAYYEGWVDEAGLRREVLDPAGPAGDGRILPSLWDARTDRASRAAYVEVPPGGVVLISGAFLLGGGLPFDVTVHLEMSAAALSRRTAAELAWTLPAYARYAEEVAPATFADLVVRVDDPRHPAIVESADDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F7V2</accession>
    <name>F4F7V2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734391.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23195"/>
    <dbReference type="EnsemblBacteria" id="AEB45739">
        <property type="protein sequence ID" value="AEB45739"/>
        <property type="gene ID" value="VAB18032_23195"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23195"/>
    <dbReference type="eggNOG" id="COG1503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054531_1_0_11"/>
    <dbReference type="OMA" id="WSERHFQ"/>
    <dbReference type="OrthoDB" id="1663523at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040701">
        <property type="entry name" value="Bact_RF_family2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18844">
        <property type="entry name" value="baeRF_family2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="39704" checksum="EC90693F1CCAD905" modified="2011-06-28" version="1">MQLSFLRPLYDRPGPWCSVYLDASLDTEDAHAALDLRWRDLQRRLAEQGADEPTVAAIDRVIRGHDPMPGDYGLAVFGTRGRVVLSEYLSAPPRRDLAAYAPLPHVMPLLAQRGEQVAWVRVVADRTGADAMSVSAGGVPRRAHVVGRESHQLRRVQPGGWSQSRYQRAAMEAWHHNAGDVTAATVELAERVGAEVVVVAGDVRATGMIAAQMPDRWQDMVVRTDAGSRAGGADQTLLDDLTVQTIAEVADQRISAALDRFGMQEDVGAGLDAVVAALQRNQVDTMLIVDDPSADGELWIGPAATDIATEPGQLPGVGDLERVRADAALVRALVGTDAELTVLGPDEAPQLTDGVGAVLRYVDPSTPGRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F840</accession>
    <name>F4F840_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication initiator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730706.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04530"/>
    <dbReference type="EnsemblBacteria" id="AEB42032">
        <property type="protein sequence ID" value="AEB42032"/>
        <property type="gene ID" value="VAB18032_04530"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04530"/>
    <dbReference type="eggNOG" id="ENOG502Z8MS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537234_0_0_11"/>
    <dbReference type="OMA" id="CGSTRED"/>
    <dbReference type="OrthoDB" id="373930at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="580" mass="64602" checksum="4C9F73BF0ED8041C" modified="2011-06-28" version="1">MTAPTLPGLTPDTPPPTDLPATVAPAAGSRAARLALPMSRQVLTEMAAEYGVCLRPVTLRRTDLHTGLTEVIDLPCGSTREDKCQPCAKRARRLRQTQIREGWHRADEPNPTGPNPATEAQRELVMLRAHLEFARDEAQRSGQFDQIPAIDQAIAEVEAATAAEGMRGQIAPGHDEEDSGARRKRSTRRRQDAPDLPRKKVEPRTLGRVYVAPDGTQHRPSMWLSLTLGSYGRVLPDGTPVDPGSYDYRRAAWDAVHFARLLDRFWQNLRRCVGWNVQYAGCVEPQRRLAPHAHFAIRGTIPRAVLRQVAAATYHQVWWPPADQPQYTLDRPPVWDNDQAAWVDPDTGEALPSWADALDLIDTNPDAQPAHVVRFGTQIHAEGVTPGTVHAQRTMGYITKYITKSAADCHKTETDRQRDHLDRLWQELRVTPCNERCANWLLYGIQPKKAHGRLQAGRCKGKVHQRATLGIGGRRILVSRDWSGKTLADHRADARAWVRNLLGVTTGAADAEPVDQDQPPAYAWELARPDDPDVPPLQHRLLRALSQRAQWKAALLAARDKATQGSSPIDVPVPTTEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F870</accession>
    <name>F4F870_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent dipeptidase microsomal dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_10565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731902.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_10565"/>
    <dbReference type="EnsemblBacteria" id="AEB43231">
        <property type="protein sequence ID" value="AEB43231"/>
        <property type="gene ID" value="VAB18032_10565"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_10565"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_2_1_11"/>
    <dbReference type="OMA" id="YAMGDDP"/>
    <dbReference type="OrthoDB" id="1145595at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB43231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="400" mass="44099" checksum="3917453AF4627068" modified="2011-06-28" version="1">MQEPAPRYAGYQSFDYLTPHVDYKVFELAPQLGRVPEHDLGLNAEQYARVARLLQEHMAISLHEHPKILPADVSQLRDYNRTGRNSFGFEGLARSGLTAVFDNFMNGTGCVTSEHAWKWDDVIYDIGLRFADIAKQDHVVVATTLEQIFEAKRNGQIALVAGLEAATMIENELDRIDILYGFGVRQMGIAYSQANMLGSGLSEDRDGGLTHFGRRAVDRMNKLGIAIDISHSGDQTSLDVIEASRVPVFITHAGARSVWNTPRMKPDEVIRACAERGGVIGIEAAPHTTLSAGHPHHSIESVMDHFTYCVELVGIDHVAFGPDTNFGDHVGLHDSFTQHLAIGKAHGVVDHPRVPYVSGMENPAECFSNIVGWLVTHGYSDDEIAKVIGGNIIRVLQEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8G6</accession>
    <name>F4F8G6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_17035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17035"/>
    <dbReference type="EnsemblBacteria" id="AEB44511">
        <property type="protein sequence ID" value="AEB44511"/>
        <property type="gene ID" value="VAB18032_17035"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17035"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_1_3_11"/>
    <dbReference type="OMA" id="VGDRWGQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="1064" mass="114956" checksum="66534C7A0B042309" modified="2011-06-28" version="1">MRFGILGNLAVWPADDRPAHLPGHKVRTLLAVLLVHEGRPVSADALADVLWGDEPPGNLIGALHTTVWQLRRALEKAESGAGTRVVVSRPPGYLLDVSDHDVDARRFEYRLRRARAATDTRDRVSILGDALAEWRGPALADFTDAEFARPAIARLEEQRLTALEDRAHAMLELGEHRLLVSELADLVVRHPMRERLRAAHMRALYGSGRQSEALAGFDELRELLAEELGVEPGTELVTLRQSILERDPVLAPSPTPITTTARPVTNLPAPVSGLIGRDAAVVQVRALLEASRLVTLHGIGGVGKTSLALAAARQVAGQYPDGVWLVELSIVAAGPDEPDPFSAVADQVAIALGVRTTAREDWLTSAVRAKQMLLVLDNCEHVVAAAAQLVGLVLQAAPGVRVLATSQEPLGIAGERLWTVPPLALPTSLAQAATSSAVQLFVARATDASAGFVLDENTVEAVDAICRRLDGLPLALELAATRVRALGVHELAARLEDRFALLTQGMRGAPARHRTLRAALDWTWELLTEPERVVLRRLAVFSGGCPLQMAEDVCAGGVVGRADVLDLVARLVDRSLVTVTDVAGVRRYGLLESVAAYSAERLREAGEEADVRLRHARYHADLAERVLPHLRGPSQRRWLERMDAERANFRAALDAGARLGANGLALRMVNALAWYWFLRGRLAEAKRAFTVALDGSPTDGGSPRATALAWQAGFGLRAGDASYDLDRFDELENEVADPVDRAIVRWFLGFTRIGFGGQDSAEKYLDRALGEFRNLDYAWGTAAALAALATRSILRGDLDATRQYGEESAALFRDLGDGWGRLQATDALASLSEVLGRYDEAARLHRDGLRIAEALGLWNEASTKMSGLGRIALLGGDYPQARELHERALRLAAEQSYTFGQQFAEVGLGLVARREGRLDAAEMHLRRWLDWCRQLDGEYGVALILAELGFVAEQRGDAETALRLHREGSVAAWGTGDPRTIALSLEGVAGTYSLLGDHERAALLSGAAQAVRAGAGAPLPPAERGDVDRITARGVAAVGDAFAKHVGDGRLMELSEARRLVFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4F8S2</accession>
    <name>F4F8S2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_23585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23585"/>
    <dbReference type="EnsemblBacteria" id="AEB45815">
        <property type="protein sequence ID" value="AEB45815"/>
        <property type="gene ID" value="VAB18032_23585"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23585"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OMA" id="NRYQVIQ"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB45815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="457" mass="46660" checksum="6ADF872B7A7BFC36" modified="2011-06-28" version="1">MLSSEVVLSGRYRLDERVATGGMGDVWRGTDLILGRQVAIKVLLPSLVSDPDFIARFRAEARMMAALRHPGIVQVFDCGEDDLASGGRADYLVMEFVTGQPLSKRIEAEGRLDVAETMSVVAQAAQALHAAHQRGIVHRDVKPSNLLVQEDGTVVLVDFGVARSVNVTSITSTNAVPGTALYMAPEQAAGRPVSGATDLYALGAVAYCCLIGSPPFTGDNPLQVAVRHLDDPPPELPHDIPEAVRALVERALAKDPADRFSSGAAMAEAARSAVSDSSLPTAMVPAAVRGPGPDTRTANTVAQAVPAGSRRGRGTLVGALTAVVVGLVALGAALSAAQQANTPAVQVPSSVPATDSVVEAEEPSDETESRPARVPPYRPAGSTGKATASPSASPSTGAPSESNEPESPEPAPSSSSPAPGPGTSTPATEPTTAPTTPPAPTTTPPGGDPPDDESEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F939</accession>
    <name>F4F939_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_04705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730741.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04705"/>
    <dbReference type="EnsemblBacteria" id="AEB42067">
        <property type="protein sequence ID" value="AEB42067"/>
        <property type="gene ID" value="VAB18032_04705"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04705"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_11"/>
    <dbReference type="OMA" id="VWLGHRD"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB42067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="445" mass="47677" checksum="A0B94DE7D422F3D5" modified="2011-06-28" version="1">MIESLLVANRGEIARRIIRTARRLGVRATAVHSEVDADLPFVREADEAVCVGPANPAQSYRNTEAILAAAASTRAQAIHPGYGFLSENADFARTVEASGLIWVGPGADAISAMGDKINARNLMAAAGVPVAPGTTEPAADLTTALAAAGEIGYPVMVKAAAGGGGMGMGVAADDDALRTEYDKVRAFAERMFGDGSVLIERYFPRVRHVEVQILGLADGRVVALGERECSVQRRNQKLVEESPSPAVSPKLRERLLAAAVRAGEAVDYRNAGTVECLLVPGTDEFFFLEMNTRLQVEHPVTELVYGLDLVEEQLRVAAGLAPTFDPDALSPRGHAIELRINAEDPKRFLPGPGVIKTWVEPTGEGVRVDSGYVEGNTVTPFYDSLMAKLVVYADTRPEAIARARTAVADFALAGPKNNLPFFTELLDNQEFTAGTYDTTLITRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9H3</accession>
    <name>F4F9H3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_17235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44551">
        <property type="protein sequence ID" value="AEB44551"/>
        <property type="gene ID" value="VAB18032_17235"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17235"/>
    <dbReference type="eggNOG" id="ENOG5032U4D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_978691_0_0_11"/>
    <dbReference type="OMA" id="ESSAWRT"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="274" mass="31430" checksum="E1D025E40989DE91" modified="2011-06-28" version="1">MDSTTLHWASRRYLMSRYEELQSDYGRLPDGGRRADGYHFTTEAKRIFPRYTVVDAMLMEVERLDPDRLPAVDVLVSMMLAAADSADSPLTDPPYDEVEAQAAADERRLFAAKVQHWSAQPGVRADPVPYRRVLTREESSAWRTSLQRRWGVQNGWWHPMLSGAVPPDVLVLTEESMWEGDGVDQVRRVLRELGRPRVVELREYKADYLLDVEIVAPRYTGPECYWTDEQHDWIAYASHEGTVAFGGVLAAALVATWPEVDRWRWPGWQAPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9M5</accession>
    <name>F4F9M5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17505"/>
    <dbReference type="EnsemblBacteria" id="AEB44603">
        <property type="protein sequence ID" value="AEB44603"/>
        <property type="gene ID" value="VAB18032_17505"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17505"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303820_0_0_11"/>
    <dbReference type="OrthoDB" id="39083at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003309179" evidence="1">
        <location>
            <begin position="30"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="979" mass="103770" checksum="AFF634941CFBAEA7" modified="2011-06-28" version="1">MRDRRTTSFAVLLAASLAATLAPAPNASATSVAEEGFQPSITYDLSVSDAERDAIHAEVEALAGRVNSARAGDGTYDPLSLVGAMLDGSSYDSISRGGTAATAYPFPVSNTPANQYEYDRKVAKLAWVVKLATDLGFPVVVQRQPDKYVYAEIGDPDAPEMIMALSHLDSPTASVSAAQLARWRDADGNLGTPGAYHSPYIKDGWVYGAGIQDDSGPTLATLLAAKALLEAGLPMDRRIRIVMGIYEDGGPGTPSAANTATFQSIPYNSNPSFYDNWAYKNLNREETPIAAYTSDSRFPVIVGNSGSVTPSVSMDLSADRTKAFRLTAATAGVTLREGDPTLKDIAYGSTTQIASRAIFTLDVAGVGSAERDRFVSAITAAATTKGWLPAAPRTTPKVQTTIAGDSLTLEINTDVAMEMPTPQYGKNAVVWGMFLLSKGLGALGSTAADMQLKKAADGIADLFFRDGVEGEAYIGKYMGIPANLLRNPNNGTPNLTLALMANINSETPTSFYTDASGNLSMPMYVRSMHVTAADSGQATAAVTAAFQAKGFTIGNLGSPIGAGLYVTHDNPLTALQFGSYQASIDHNPDEFADPHSLRDVVYPQGTTGGTLASNFRNKMTAFGAVLPGNERWWHTANERMKVDSAVQMTKIMADGMLEMARYSGPAGAKFMWADMPGLNADRSDLDLLDVTIGTFKDASAAVGTNQLGNQALLGATSFNIPMWNGRGNSAPTASAFALGHAPGGVYLPLTDPEYLNSTYVAPMRLEFKVERPDHMSDAAWAKFVAGGYGDFQFNILVGDRVVPLAVPAGQSADRYFFSRMSANNPDAIYLSVNLAITDAPYTGVRTILADSKTDLYTVNPAYLASNPDPFPGRGAIEQRGFFLFGDGQKNAEFSSPDAVYVTVANAVVDAKPAAVVKKLKGNTNELTITVQRTHVDGSESAVTATFTINNNAAGTYTVGDHKVYVDTKGNTQVRSISIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9M9</accession>
    <name>F4F9M9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_17525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733262.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_17525"/>
    <dbReference type="EnsemblBacteria" id="AEB44607">
        <property type="protein sequence ID" value="AEB44607"/>
        <property type="gene ID" value="VAB18032_17525"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_17525"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2290483_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="101" mass="10625" checksum="C1869B9902DC4BA8" modified="2011-06-28" version="1">MSAFGTPVKHAAWRDKPSWAVIATDDKAFDQATLQHMAKRIGAEITNVAASHAVFMTQPAVVADVTTARGSAVRGSGYGCRWPDGAGRRPTDSGAAGKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9R1</accession>
    <name>F4F9R1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_23695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23695"/>
    <dbReference type="EnsemblBacteria" id="AEB45837">
        <property type="protein sequence ID" value="AEB45837"/>
        <property type="gene ID" value="VAB18032_23695"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23695"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_11"/>
    <dbReference type="OMA" id="HPCIMAP"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="464" mass="47900" checksum="0856E2FA57A556D4" modified="2011-06-28" version="1">MADRRGAGMSEQVFLLPDLGEGLAEAEIVQWRVAVGDVVTVDQTVVEVETAKAVVDVPCPYAGRVVALHGAEGEVRPVGQPLITVVADGGSEPVGHAVYREEERAGSGNVLIGYGTGHGGARRRRRARPVAHATASSVPAAAPVPAAVAPALAPAPVAALASSQPATALVISPIVRRLARERGVDLATVRGSGPGGVIRRADVEAAADVAISPVAAASPAEQSAAHVGLAPTGAGDQVIPLTGIRKAIADKLSRSRREIPEVTIWVDADATALLATRAAINAAYPDRPVSILALLARICLSGLRRYPQLNARVDTEGQRIVQSAGVHLGIAAQTDRGLLVPVLRDADRLTTMELAAELAVTTQAARAGELPPARLTGGTFTLNNYGVFGVDGSTPIINHPEAALLGVGRIVDKPWVVDGQLAVRKVTQLSLTFDHRVCDGGVAGGFLRHVADCVERPEALIAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9T5</accession>
    <name>F4F9T5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_23815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734513.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23815"/>
    <dbReference type="EnsemblBacteria" id="AEB45861">
        <property type="protein sequence ID" value="AEB45861"/>
        <property type="gene ID" value="VAB18032_23815"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23815"/>
    <dbReference type="eggNOG" id="ENOG50335CN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_958556_0_0_11"/>
    <dbReference type="OMA" id="ACWRPLF"/>
    <dbReference type="OrthoDB" id="1695614at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046037">
        <property type="entry name" value="DUF5995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19458">
        <property type="entry name" value="DUF5995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="29226" checksum="7100E09665415230" modified="2011-06-28" version="1">MSERVWGPIHGDIVDLLADHPTDVPAVVDHLTKLQDMLVRLPPLLESCPLADFNKLYLTITTSVLDGLYADRFVDPAFLSRLDVEFAARYFDALRLWTDSSPGTPKAWSCLFERMRGPDARPLPSAAAGVNAHINFDLPFALVTTFAHLESEPVDGSDQHRDYLEINKIFADKIPGLRRGYLERWQLLIDMLNGEIDDWYQGELIGYTRDVAWRNAQRVWRCRHDPHLHERERKRLDETAAALGRLLLSPLGAFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4F9T9</accession>
    <name>F4F9T9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_23835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734517.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_23835"/>
    <dbReference type="EnsemblBacteria" id="AEB45865">
        <property type="protein sequence ID" value="AEB45865"/>
        <property type="gene ID" value="VAB18032_23835"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_23835"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035309_0_0_11"/>
    <dbReference type="OMA" id="VASIGYC"/>
    <dbReference type="OrthoDB" id="1809199at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="405" mass="40474" checksum="4843683C4CE5D609" modified="2011-06-28" version="1">MDPSAIPTAAPVSSGPSRTVLAARNGVAVVFALNGLAVATWFARVPAVRDGLDLTPGRLGLLLLAMSIGAIIAMPTAGLVTQRLGTARAVVVSTLILAVGLTVAGVSASVLDSLAGVALGLFAIGYGSGSCDVAMNIEGAAVERRLGRTVLPRFHAAWSLGGVAGAGIGAGAARLGVSIALHLTVLAALVLAGTLLGARAFLAAEPDAQPSTPADRRRRLLAAWREPRTLLIGLLVLAVAFAEGSANDWLAVAFIDGYGFSEAAGAAVFGLFVVGMTVGRTVGTVALDRWGRGPVLGVTMVLAIVGAGLAVLAGSGPVAVVGVLLWGLGASLGFPVGMSAAADEEEHAHVRVSVVAVIGYTAFLAGPPLLGLLGDQVGTLRALLIVPILLIPTLALIPAARPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAC0</accession>
    <name>F4FAC0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein tetr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05275"/>
    <dbReference type="EnsemblBacteria" id="AEB42181">
        <property type="protein sequence ID" value="AEB42181"/>
        <property type="gene ID" value="VAB18032_05275"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05275"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_2_11"/>
    <dbReference type="OMA" id="MNFAWAG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="194" mass="21376" checksum="FE9216A54D8A5E75" modified="2011-06-28" version="1">MLDAAVRVFSRHGYHGASMDEVAERAGISKPMVYAYLGTKEELFIACLHREATRMMEAIAGAAVPGLPADERLWHGLRAFFGFVGVHRDGWAVLYRQARAERAFADELAGMRARIVEVVVGMLDHALRAEGREVAETELEVVAYALVGATESLGDWLADHPEADPEKTATRMMNVAWLGAGQLLHGVTWHPPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAG1</accession>
    <name>F4FAG1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="16" type="ordered locus">VAB18032_11360</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732059.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11360"/>
    <dbReference type="EnsemblBacteria" id="AEB43388">
        <property type="protein sequence ID" value="AEB43388"/>
        <property type="gene ID" value="VAB18032_11360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11360"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_0_2_11"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="1419877at2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="181"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEB43388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="332" mass="34932" checksum="2C9C807DED4EE860" modified="2011-06-28" version="1">MSGHVAVLGAGSWGTAFAKILADAGRDVTIWARRQPIADVIRTERRNPEYLPDVVLPDRVTGTGDAAEAIKGAEMVVLAVPSQTLRGNLAEWVSHLHADATLVSLMKGIELGTTKRMSEVIIETAQVAADRVVVVSGPNLAPEIAAEQPAATVVACTDVDRATLVQRSITTPYFRPYTNDDVIGCELGGAVKNVIALAYGIATAMGFGHNTRAMLVTRGLAETARLGVALGADPLTFAGLAGMGDLVASCSSPSARNRTFGEHLGRGATLEEARVATRQTAEGVKSALAIRDLARAHGVEMPITEQVELVCHEGVDPRVAVRALMSRTTKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAZ6</accession>
    <name>F4FAZ6_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_24305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734611.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24305"/>
    <dbReference type="EnsemblBacteria" id="AEB45959">
        <property type="protein sequence ID" value="AEB45959"/>
        <property type="gene ID" value="VAB18032_24305"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24305"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021898_1_0_11"/>
    <dbReference type="OMA" id="EACGQYA"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="606"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB45959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="709" mass="74308" checksum="F063847B7560C0CB" modified="2011-06-28" version="1">MTSHRTASERADVPTHPGHDVRLGWARRAAWPVCVATLLLSAAAVGLAVLNRATVNDVTHLFLVVTNAVVGATVAARRPEHPIGWLALTSGFCFALQEACGQYAAHGLVVAPGSLPLAAALAWPQNWLWVPGNAAMALIPVFFPDGRPPSPKWRPAIWAVLVTGAAAMVTGALRPGANEQVAPVGAVNPLGVAGWQPIADLTAGAATLTSALIFLAAGAALAWQARRARGVRRQQVKWLGYAVALAVTVVAARLVAGSTDGRPGLFPYGSVFWDLAGGISGALIPIAIGIAIRQHRLFDIDLLISRTAVFVALSTAVGGTYVLVVGLLGAGFDASASLPVSFVGAAAAALLVAPLRHWLQRRVNLLVYGERDDPYAVLARLGQRLEQTQDAAAVLATSTATVREALQLSYVEIATVDGWSYRLGVPPAEPVRLPLAAGEPVGHLLLGPRAGESALGARELRLLRDLARHIGVAVQAVRTLDRAQSLAADLQRSREQLVLAREEERRRLRRDLHDGLGPTLAGLTMRAEAAQELGPGAATQRLLEEIVVDARTAVADVRRLVNGLRPPALDTMDLAAALRSHVATGPADGPRVLVDVPATLPPLSAAAEVAAYLIAVEALNNARRHARADTVELRLWVEHGMLHLRVRDDGCGRRPGRPDGVGMHSMRERAEELGGSCVVTSTPGGGTEVTATLLTGTKGTDGSDPGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F4FAZ8</accession>
    <name>F4FAZ8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_24315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734613.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_24315"/>
    <dbReference type="EnsemblBacteria" id="AEB45961">
        <property type="protein sequence ID" value="AEB45961"/>
        <property type="gene ID" value="VAB18032_24315"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24315"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092618_1_1_11"/>
    <dbReference type="OMA" id="WVLDGNY"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="175" mass="20357" checksum="07EA75C4F1389652" modified="2011-06-28" version="1">MNPPSRILVYGVHGSGKSTLAHLLAQRLGLPWYPVDDLLWEPRWVEVPVAVQRSRIEAICRRERWILDGAYHGWRDVPLARADLVIGLDYPRGLSFRWLLRRTMNRLSTGEIICNGNRESLSSVLSWDSVLRWHLTEYGKERRRMRAWHQDSSGPPVLLFDTPQALERWLAGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB54</accession>
    <name>F4FB54_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase m23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_00575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735844.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00575"/>
    <dbReference type="EnsemblBacteria" id="AEB47199">
        <property type="protein sequence ID" value="AEB47199"/>
        <property type="gene ID" value="VAB18032_00575"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00575"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_12_3_11"/>
    <dbReference type="OMA" id="DGTYTQY"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="118"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB47199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="237" mass="25239" checksum="B9BB6C8A9EAFEC99" modified="2011-06-28" version="1">MRQRLSSEPDRYRGRRRVPTPPRSRYAAVVTTAFVGAGVVALGAGALPDAKSVNPSVLDELKQASISSQGAADRADAAERASRDGRGASEIVADSGVWLLPLQGYDFNSPYGMRWGKLHTGIDLVAPEGTPYVAIHEGKVTKAGWFGGYGYAVIVQHADGSEAIYGHSSALSVREGQQVKAGDQLGLVGNTGHSYGSHLHLEVHVKGQPLDPVPWLQERGVDIKLQVEAIYSEVADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB57</accession>
    <name>F4FB57_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_00590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735847.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00590"/>
    <dbReference type="EnsemblBacteria" id="AEB47202">
        <property type="protein sequence ID" value="AEB47202"/>
        <property type="gene ID" value="VAB18032_00590"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00590"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_11"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="319"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB47202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="797" mass="87847" checksum="7CFBAE5011633BCF" modified="2011-06-28" version="1">MHPLFDIPVSSPAPEQPPRRVAAPGHLDPLQLVEGLNGPQRDAVTHAGSPLLIVAGAGSGKTRVLTHRIAYLLAARDVHPGEIIAITFTNKAAGEMKERVAKLVGPRARLMWVSTFHSACVRILRAEHEHAGLKSTFSIYDADDSRRLMQMVARELDLDPKRYPARGLAAQVSNLKNELVDPEAFAARASGPNERALAEAYTLYQRRLREAHALDFDDLIMTTVHLLQSHPHVAETYRRRFRHVLVDEYQDTNHAQYVLIKELVSGTEGLEPAELCVVGDADQSIYAFRGATIRNILEFERDFADARTILLEQNYRSTQTILNAANAVIDRNTSRKPKRLWSDAGTGEPIVAYVADTEHAEADWVAREIDRLVDDGETRPGDVAVFYRTNAQSRVFEEVFIRVGLPYKVVGGVRFYERKEVRDALAYLRAVVNDDDTVSLRRILNTPRRGIGERAEACVEALAGRDRISFGAALRRAKDAPGISSRAANGIADFVALLDSARELTVDGTPEEVLEAVLTRSGYLTELEESLDPQDAGRVDNLQELVSVAREYTERIESTGEEGERATLAGFLEQVALVADADQVPTDDPDHQGVVTLMTLHTAKGLEFPVVFLTGLEDGVFPHLRSLGDTRELEEERRLAYVGITRARQRLYLSRAVTRSAWGQPSYNPPSRFVEELPPELVRWERTEGSYTSWGGGGGGVGGRAERTPGGRGTFSGGTPRAVQLARKLGVDGSRLATASELPQGPKVVAGDRVNHQRYGLGRVVTVEGHGPSARAQIDFGDQTLWLVLRHAPIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4FB87</accession>
    <name>F4FB87_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_00740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735877.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_00740"/>
    <dbReference type="EnsemblBacteria" id="AEB47232">
        <property type="protein sequence ID" value="AEB47232"/>
        <property type="gene ID" value="VAB18032_00740"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_00740"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="KTTDITH"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB47232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="28447" checksum="6B76461A3AFDD41A" modified="2011-06-28" version="1">MSANPLLELRGIDKSFGPVQVLRDVAFAAYPGEVTALVGDNGAGKSTLVKCISGIYPVDAGEFIFDGRPVTINSPRDAASLGIEVVYQDLALCDNLDIVQNMFLGREKRNGLVLDEPTMEQMAAETLAGLSVRTVKSLRQHVSSLSGGQRQTVAIAKAVLWNSKLVILDEPTAALGVAQTAQVLELVRRLADNGLAVVLISHNMNDVFAVSDRIAALYLGQMVAQVKTTEITHAQVVELITAGRSGELGLAADPGVNGNGAAPADSTAGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBA2</accession>
    <name>F4FBA2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05360"/>
    <dbReference type="EnsemblBacteria" id="AEB42198">
        <property type="protein sequence ID" value="AEB42198"/>
        <property type="gene ID" value="VAB18032_05360"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05360"/>
    <dbReference type="eggNOG" id="ENOG50331V5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398920_0_0_11"/>
    <dbReference type="OMA" id="DSTRQQG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="665" mass="66186" checksum="E95768369255085E" modified="2011-06-28" version="1">MTLVAGNVAAGDTKSGNVQISATIGGESGGAQREVTVRGPNPPPTTQAPQTVRSISGKVVNQAGDGVPNAYVLLKDSAGKQYETNANSDGNFRFTGTSERPIAPGRIDLGASANSVREVVSFTANAGQSVTGQRITLAIQASNSPTPTPTASESAVPTEDPFDDELADEVDEAPAESAAPPAQASNEDSGGFGNWLLVLLGGLFVAVGVGTIVLLWMKRKENDDAEVDGDAPAGAPAGAVPAARGSFAGADDQTRVVSRVGNTPDPTMVAGAGISNAPTMMHQPIVDDVPPDPYGAPPAPPYGAAPGAAQAWSGGGYGDEPGGYGASGYGNAPSSGSGYGTSPSSGAGYGGRDYGAGSAGADYPPAGGAAGYGERYDEPTGRYTGDETRYPAPADPYATGLYEPEAGKGYGSSEPAGYGRGEPTGGYGQSEPTGGYGQGAPAGGYGQAEQPGGYGQGGSTGGYGSADRDYNRGEPTGSYGNGSGYGQSEPATGYGQGAPTGGYSPSTPAGGYGQGETTGSYGRTDPVGGYGQSEPTGGYGQSEPAGGYGQAAEPTGGYPPQTGGYGQSAAGYGQTGGYDDPGRYGQAGYGGGYGGQEPPQQRSGYDGGYDQNTGGYGQEPPRQRGGYDNGYEQGGAYGSDPAQAGRGRPDGSPTERGRRLDWLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBA4</accession>
    <name>F4FBA4_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="12" type="ordered locus">VAB18032_05370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730874.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05370"/>
    <dbReference type="MEROPS" id="C44.A03"/>
    <dbReference type="EnsemblBacteria" id="AEB42200">
        <property type="protein sequence ID" value="AEB42200"/>
        <property type="gene ID" value="VAB18032_05370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05370"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_2_11"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="489"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEB42200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="533" mass="57043" checksum="CE1820E54E4DDC40" modified="2011-06-28" version="1">MPRGDGRLSHDLDPQRPGPQDACGVFGVWAPEEEVANLTYFGLYALQHRGQEAAGIAVSDGSGVVVYKDLGLVAQVFDEPTLASLRGHVAIGHTRYSTTGGSTWENAQPTIRATSSGTTIALAHNGNLVNTAELQREVTDRGLTADGSTNDTSLVTALLASRPDLSVEAAALEVLPQLRGAFSFVFMDETTLYAARDPHGVRPLVLGRLERGWVVASETAALDIVGASVVREVEPGELIAIDAEGLRSSRFAAPEPKGCLFEYVYIARPDATIAGRNVHAARVQIGRQLAKEHPVEADLVIPVPESGTPAAIGYAEESGITYGAGLMKNPYVGRTFIQPSQTLRQLGIRLKLNPLRQNVRGKRLVVVDDSIVRGNTQRAIVRMLREAGALEVHVRISSPPVSWPCFYGIDFATRAELLANGLDNEGIRRSIGADTLGYVSLPGLIAATEQPKTRLCRACFDGEYPIDLPVGNLIGKHVLEGIGRRVAHNSDDSDSAEQPVPPLVAAAGADDDLNRSRRASRSDLKISATTNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBD3</accession>
    <name>F4FBD3_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding lysin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_05515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013730902.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05515"/>
    <dbReference type="EnsemblBacteria" id="AEB42229">
        <property type="protein sequence ID" value="AEB42229"/>
        <property type="gene ID" value="VAB18032_05515"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05515"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727383_0_0_11"/>
    <dbReference type="OMA" id="WFGWATF"/>
    <dbReference type="OrthoDB" id="229486at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="171"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="399" mass="40379" checksum="5154B8681895B63D" modified="2011-06-28" version="1">MAASGGTAVRRLGRILTGFGALVVLLGLLVGGPIALLAFAGNPLPDHVPTLAEIGTTLTSRDDGQLFLRALALVGWFGWATFAISVLVELGAQALRRPAPRLPGMGRQQRAAAALVGSVALILVASPAAAATAAYTSGPYTAPTTTVAYTSPAGSTTMGSQATVRTDLDAPVYQVAKGDYLGKVADRYLDDFDDYRTLAALNGLRNPDQIRPGQLITLPTEAKDQGVRAHATGRLVTPNRPSPAPAAPDSGAGTPTPTKPDGSGPGGSGPGGTGPGGATQDGATRGGASGQPGGSTSQPGSATPAPAAPEDRQPTAPRDKVSDDRPPVVTVGAARAGDPDRVNRPLAISAVLAVASIVGAQIGAVLGLRRRPVTTSASTWQHRRSSAPRELPTGRHRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBH9</accession>
    <name>F4FBH9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class V aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_11635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732110.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_11635"/>
    <dbReference type="EnsemblBacteria" id="AEB43441">
        <property type="protein sequence ID" value="AEB43441"/>
        <property type="gene ID" value="VAB18032_11635"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_11635"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_3_1_11"/>
    <dbReference type="OMA" id="TGNCHKW"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="60"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="393" mass="42315" checksum="C618AAEB0B16FD90" modified="2011-06-28" version="1">MSVPLPPEPIPGARLLFSLDPAVSHLNHGSFGAVPITVQRAQQRLRDEMEADPLRFFTQGLIDRITHARRHLAGFLGADPDGTALTVNATTGVAVALQSVGLRPDDEVLTTDHGYGAVDFAVRRECHRTGATHRVLRVPLSATTEEIVQIVRSGLRPGRTRLVVVDQLTSATARLFPVAAIVGVAREHGVSVLVDAAHAPGMLPATVQSIGADFWVGNLHKWGYAPRGTAVLVVSPPWRERVEPLVVSWEQEAGFPGRVEWQATADYTGWLSAPVGLYVLRTLGVDRVRAHNAALAAYGQRVVGDALGVRPADLPDPGGPTVAMRIVPLPAGLATTMDGARALRARIAERLAAQVAVNTWDGRGWLRLCGQVYNSPDEYDRLAVQLPTLLDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F4FBT7</accession>
    <name>F4FBT7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-(Acyl-carrier-protein) synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_18175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733392.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_18175"/>
    <dbReference type="EnsemblBacteria" id="AEB44737">
        <property type="protein sequence ID" value="AEB44737"/>
        <property type="gene ID" value="VAB18032_18175"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18175"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_11"/>
    <dbReference type="OMA" id="MNNNFAF"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB44737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="420" mass="44434" checksum="04CBC867F40CDA9A" modified="2011-06-28" version="1">MSRRRIVITGIGVVAPGGIGRKAFWDLISAGRTATRQISLFDATGFRSRIAAECDFDPLLEGLSPQEVRRMDRAAQMAVVGAREAVTDSGLTFEALPPDRTTVSVGSAVGCTTGLEEEYVVLSDGGRQWLVDHTYGVPHLYGYMVPSTIVSEVAWTVGAEGPVALISTGCTSGLDAVGHAVEVIREGTADVALAGATDAPISPITVACFDAIKATSARNDEPDSASRPFDRYRDGFVLGEGAAMFVLEEYEHARRRGAEPYAEVAGFASRSNAFHMTGLRPDGREMAEAIDAALRQAGRAPGDVDHINAHGSGTKQNDRHETAAFKRSLGGRAYEVPVSSIKSMVGHSLGAIGSIEIAACALALRHQVVPPTANLHHADPECDLDYTPLVAREARLRTVLSVGSGFGGFQTAMVLTAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCC7</accession>
    <name>F4FCC7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplN</name>
        <name evidence="6" type="ordered locus">VAB18032_01110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007073026.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="SMR" id="F4FCC7"/>
    <dbReference type="STRING" id="263358.VAB18032_01110"/>
    <dbReference type="EnsemblBacteria" id="AEB47306">
        <property type="protein sequence ID" value="AEB47306"/>
        <property type="gene ID" value="VAB18032_01110"/>
    </dbReference>
    <dbReference type="GeneID" id="5705099"/>
    <dbReference type="GeneID" id="67457624"/>
    <dbReference type="KEGG" id="vma:VAB18032_01110"/>
    <dbReference type="PATRIC" id="fig|391037.6.peg.4346"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_11"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="122" mass="13273" checksum="C9D9012573EAF2BB" modified="2011-06-28" version="1">MIQQESRLRVADNTGAREILCIRVLGGSGRRYASIGDVIVATVKDAIPGAGVKKGDVVKAVVVRTAKEKRRPDGSYIRFDENAAVIIKDGGDPRGTRIFGPVGRELRDKRFMKIISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCF0</accession>
    <name>F4FCF0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_05755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_05755"/>
    <dbReference type="EnsemblBacteria" id="AEB42277">
        <property type="protein sequence ID" value="AEB42277"/>
        <property type="gene ID" value="VAB18032_05755"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_05755"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_5_2_11"/>
    <dbReference type="OMA" id="AGRFEWY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="195" mass="20007" checksum="7992D8F6F3F58CF6" modified="2011-06-28" version="1">MPYSPAPGPLTANVPGHPATADDDPAAIGRRVRALREARGISLSALARQAGVGKATLSGLENGTRNPTLETLYAITAQLGVPLTAVLSAPASGATVRGAAVSATLLEVFEDSDVTYELYRMQVAPGPGQLSPAHQAGVTEHVTVFTGVLRAGPVDAPLTAAAGGHLRWASDVPHVYAAVGDEEVTASLLLRYPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F4FCS8</accession>
    <name>F4FCS8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_12290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732241.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12290"/>
    <dbReference type="EnsemblBacteria" id="AEB43572">
        <property type="protein sequence ID" value="AEB43572"/>
        <property type="gene ID" value="VAB18032_12290"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12290"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="ALINCPK"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB43572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="220" mass="23722" checksum="C430D9D34B91A2CB" modified="2011-06-28" version="1">MLVLRNVSRTYQDGQPVHALRATNLRVDQGDYISITGPSGSGKSTLLNLVGLLDVPTAGSYLIGGLETADCGPATLGAIRGQLFGFVFQAFHLLPGRTALENVELGMLYGPHARRQRRSMASEALERMGLSHRMHADPRQLSGGEKQRVAIARAVAARPQVLFCDEPTGNLDTTNTAAVLAVLRQLNEEGLTLIVVTHDSQVASEARRRLRVTDGVVDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD65</accession>
    <name>F4FD65_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_24985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734747.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB46095">
        <property type="protein sequence ID" value="AEB46095"/>
        <property type="gene ID" value="VAB18032_24985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_24985"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2025532_0_0_11"/>
    <dbReference type="OMA" id="DIFTIGP"/>
    <dbReference type="OrthoDB" id="1924362at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="127" mass="13915" checksum="D93341A3873DE944" modified="2011-06-28" version="1">MTCHGGSLKYSAATAVGVDHVRLSYHYLNIGDIDGYGSLLDENVQVQRPDMAHGCGRNEVLRTHALVAGPPSHHQIYKVIADGDGVAVTGRYTDLPGRTTLDFVDVFTLTDEGMLLGYRRFYYVAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4FD92</accession>
    <name>F4FD92_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding region ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_25120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25120"/>
    <dbReference type="EnsemblBacteria" id="AEB46122">
        <property type="protein sequence ID" value="AEB46122"/>
        <property type="gene ID" value="VAB18032_25120"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25120"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002554_0_0_11"/>
    <dbReference type="OMA" id="RRNVNAM"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="552"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="666"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB46122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="834" mass="89953" checksum="6401AC41B8FF618D" modified="2011-06-28" version="1">MAAGPDQASTVSNHRRRRFDVRVVPHRRRSALRLRDWRMRTKLATVLVIPSVAFLVLAGVQTQSLVSRANTLSDFAAQVGIGPEIADLVHWLQQERDRTAGELSALRAASSEEESAQVVEVLRPYRDGVDQAAQALHRAAEPVGKGDSSWAETYSVAHQAYQQILYMRNVMTTVVLSDDTILGNYHRAVDALLTLLARPSPGTERPELSDAVLRYVQFARAKDLSSRVRAELYAAARNGGYQDNDRAQLNDLRSRQLTALGAFRVAASNAQVARYDQMSQLDPFVQAGRLEERALTQNPTALTLLADDDWWTFSEVRHDLLRDFEAGILADSATQADRASAAQLRETLLMVGVIITVLLVAVLISVLIGRSMARSIRLLRSQALRIAQIELPDALARLRSVSGGVPQIEVSPAVVRSLDEIGELAEAFVAVHRSAVGVAVEQANMRRNVNAMFVNLARRSQVLVERQLELLDDLEREESDPDQLENLFKLDHLAARMRRNDESLLVLAGTESTRRWNRPVGLNAVLLAASAEIEQYQRVRHEAVADLHLVGHAVGEVVHLLAELLENATAFSRPDTIVQVMARAEGAGATVEIADQGLGMSPTALAEANAVLAEPPAADVATVERMGLFVVSHLAARHGIEVRLHGGTGGLVARIRLPGALLAAPPPPGLDPVPSPRALPVPRSPAPVTAAQPVELPVAGRRPTTVPRQAHPVPVRAEDVLAPAAAPASTGSGWWSREGPSSPATAGSPAPPSVPVTGGTNDRGLPMRVPMAQLRSVTQPAQPGQQQVARHDPDPEAVGGMLSKLYSGVRRAEAEETTEIPVPSPGTWSEGGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDB1</accession>
    <name>F4FDB1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_25215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25215"/>
    <dbReference type="EnsemblBacteria" id="AEB46141">
        <property type="protein sequence ID" value="AEB46141"/>
        <property type="gene ID" value="VAB18032_25215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25215"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_40_3_11"/>
    <dbReference type="OMA" id="TEVFWAA"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB46141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="182" mass="19408" checksum="69E6063F0C70658B" modified="2011-06-28" version="1">MEPGGDAIVATAWQLAEAEGWAAVTARRLAERAAVDLGELYERFADRDAVVAAVAVRGFADLAAALAAARTTADTPTQGWPAVVAAYLDFAYANPEVYDAMFAHTPDLTLGAEQTPETVTATFGELRAALAPLAAGRDEDTLSELGWSLLHGMVMLTRGGRLRPEAQDHRETLLTHHLFPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDD2</accession>
    <name>F4FDD2_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ordered locus">VAB18032_01295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735979.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01295"/>
    <dbReference type="EnsemblBacteria" id="AEB47343">
        <property type="protein sequence ID" value="AEB47343"/>
        <property type="gene ID" value="VAB18032_01295"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01295"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_2_0_11"/>
    <dbReference type="OMA" id="QIGAIKF"/>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="47"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="176" mass="18510" checksum="15C77E9E13AA4B27" modified="2011-06-28" version="1">MKLEDLARQVNARARLTGEFVLRSGRTANEYFDKYQFEADPVLLDALAEQMVALVPAGTEVLAGLEMGGIAVVTALGRHTGLPCAFVRKTAKPYGTARLAEGAEVADRQVLVVEDVVTSGGQVVLSTRDLRSLGARVDAAVCVIDRQEGGSEALAAEGIALRALLTRADLGAHGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDH1</accession>
    <name>F4FDH1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_01490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736017.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01490"/>
    <dbReference type="EnsemblBacteria" id="AEB47382">
        <property type="protein sequence ID" value="AEB47382"/>
        <property type="gene ID" value="VAB18032_01490"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01490"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_0_1_11"/>
    <dbReference type="OMA" id="FVIIAMQ"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB47382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="372" mass="38505" checksum="D3DCAAEF3BCB42A7" modified="2011-06-28" version="1">MTEVKSPEVTAPAAAVPSESTGWSRLRPFLPLVVLAVALILPYSTLHLPGVFEGALNSPGTLQLLAVCLVFGGLAAGYDLLFGRTGMLSFGHALYFAAGVYGTDILITRVGLPLWQAAPLAIVGGIILAGLVGAVALRTVGIAFAMVTLAFAQVGAILVARDFGGLTGGEEGLPLDVTGVPSGLVGVANTVNLYWLALAYLVVVVFVVHRVSNSPTGRVLAGVRDDERRIGVLGLDPYRFKLVAFTLAGGLAAAGGVVYCLIVGGASPHITSSELTLSLLVMVVLGGPGTRWGPVLGGILYMYLDHRLISVGSSGAIDALPAFLSRPLSQPLFVLGTVFILAVYFFPGGLASLAPRLALLRNALRLGPRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDN1</accession>
    <name>F4FDN1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_06350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_06350"/>
    <dbReference type="EnsemblBacteria" id="AEB42394">
        <property type="protein sequence ID" value="AEB42394"/>
        <property type="gene ID" value="VAB18032_06350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_06350"/>
    <dbReference type="HOGENOM" id="CLU_2426170_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="91" mass="9475" checksum="0CE86011040F5058" modified="2011-06-28" version="1">MLLVSLLISARHGVNAEHTEAAHARGLGPLDPQPANRTDVARTTVSILAASARHVRMRCSVRPPLPVGTGQADRPAATTGPRATVSPPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FDS2</accession>
    <name>F4FDS2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_12445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732272.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_12445"/>
    <dbReference type="EnsemblBacteria" id="AEB43603">
        <property type="protein sequence ID" value="AEB43603"/>
        <property type="gene ID" value="VAB18032_12445"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_12445"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_0_0_11"/>
    <dbReference type="OMA" id="LLDVRWQ"/>
    <dbReference type="OrthoDB" id="920668at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="167"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="285" mass="28983" checksum="2F55EABF9FF754D8" modified="2011-06-28" version="1">MSATDGLLVEAAQLAAELDTADPPTLLDVRWRLAGPPGRIDYAAGHLPTAVFVDLDTALCGPPGPAGRHPLPDPAALQAALRAAGVRAGHPVVVYDGGDGMAAARAWWTLRWAGHRPVRVLHGGFPAWLAADLPVSTDEPHPVPGDVTVTPGGLPVLDAAAAARLAAADAGVLLDVRAAPRYRGEHEPVDPVAGHVPGAVNLPAPEYVADGRFPSGAALRDRFATAGVSAEAPVGAYCGSGVTAAQAVLALHLAGRTDAALYVGSWSNWVADPDRPVAVAPPPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F4FE08</accession>
    <name>F4FE08_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_18875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733532.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB44877">
        <property type="protein sequence ID" value="AEB44877"/>
        <property type="gene ID" value="VAB18032_18875"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_18875"/>
    <dbReference type="eggNOG" id="ENOG5033WFN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577230_0_0_11"/>
    <dbReference type="OMA" id="TAGIWFE"/>
    <dbReference type="OrthoDB" id="1605893at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="541" mass="54932" checksum="ACCC9AC0598A514D" modified="2011-06-28" version="1">MLRTPFAGRIDAVAVRRWVSGALALTCAVVLTAGCSRVKLPGGGGDADDRYGYAPKPDDSVVYQPDVVLVEGGGKAIRSVSDDGFTYVVDGDAPGADELQPGKIMFATSQAVGRVVRVENSGGDRAVTLAPVQLTDVVRDADITFDQPLDLTAQQFSPLPDLLGEVVEEDAPATPVLPDAADATGLTGNAIGLGGGMGGGALGLSGRTGGGTLDLRGGTGGALGLGANESELSDLRIAVPPIVLGPARAPGGGGATHSMERKIGGWGVTAYLGRTKVGLTAQHSTAASGLKVDFDIQLLLDNLRLSGNVKVTNGVIPHPRFRIDGVHGLAITVAAGAQGGLSDNKKARIELPIELSQPIIIGGFPATLKQTFKFLVQTAFTAKNGNISGTGRWGLTGPIGYEGGSVLTPTFSVQESIMQSLRGVSVGVEAIVVAAEFRFGLMLGLPVAGAGPFVGVVASLGLTNGSAAGRVGLPLAGPAVKCRGTTLVVTARAGEGLNVSAPLAKAIEVVLGVPIPKEATFVSKDIINRTVVEPDVPLCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEH7</accession>
    <name>F4FEH7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736054.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01675"/>
    <dbReference type="EnsemblBacteria" id="AEB47419">
        <property type="protein sequence ID" value="AEB47419"/>
        <property type="gene ID" value="VAB18032_01675"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01675"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939903_0_0_11"/>
    <dbReference type="OMA" id="ANKHANR"/>
    <dbReference type="OrthoDB" id="1892992at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="296" mass="30656" checksum="07C54F30FAECC4BB" modified="2011-06-28" version="1">MTTTNRSSRGWAYLGLALGGLVSVAANIAHSFIAPDNAPAAWSPEPGKVVSAIVWPLFLFIAIEILARTPWPTGLGWNLLRWVGFPPVALVAAFVSYRHLSGLLDHYNEETLVVWLGPLAVDGLMLKATAALLANKHANRPTETVPAPAPATIAEAPSTDITASPKVRPAAATPATNPEPTSEPTPEPINLPTSGEDTRTATTVEPTPDTTDKDPTPATPVPATVTTGPPAALLPNARIVAAAHEKAHGEPITAGQLAVRLRVPTNTAADILTALNTNTPTATNKTHNGTAVGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEK5</accession>
    <name>F4FEK5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1713 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_01815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007465623.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01815"/>
    <dbReference type="EnsemblBacteria" id="AEB47447">
        <property type="protein sequence ID" value="AEB47447"/>
        <property type="gene ID" value="VAB18032_01815"/>
    </dbReference>
    <dbReference type="GeneID" id="67459846"/>
    <dbReference type="KEGG" id="vma:VAB18032_01815"/>
    <dbReference type="eggNOG" id="ENOG5032FU9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209136_2_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="COX24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1713" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="33" mass="4115" checksum="8156BAADC1929EF5" modified="2011-06-28" version="1">MGSVVKKRRKRMAKKKHRKLLRKTRVQRRRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FEN0</accession>
    <name>F4FEN0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_01940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736106.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01940"/>
    <dbReference type="EnsemblBacteria" id="AEB47472">
        <property type="protein sequence ID" value="AEB47472"/>
        <property type="gene ID" value="VAB18032_01940"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01940"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062591_0_0_11"/>
    <dbReference type="OMA" id="FRHGGFE"/>
    <dbReference type="OrthoDB" id="1244860at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB47472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="263" mass="28508" checksum="DAB01EAC858BFAC7" modified="2011-06-28" version="1">MAARTPRPLGTITRGTTNPNRLRRVDNWIVDTCGDALRAAPDPLVVDLGYGASPVTAVELRARLAAGVRTDVRVVGLEIDPIRVADAQPAADPPGLTFARGGFELAGLRPALVRAFNVLRQYDESEVAAAWATVTSRLAPGGLFVEGTCDELGRLAGWILLDATGPRTLTLAARLSTLQTPAELAERLPKALIHRNVPGEPIHDLIRALDDAWHAAAGYAPYGPRQRWLHTVAAVRAQGWPILHRPRRWRQGELTLPWPSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF67</accession>
    <name>F4FF67_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase m23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_19350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19350"/>
    <dbReference type="EnsemblBacteria" id="AEB44972">
        <property type="protein sequence ID" value="AEB44972"/>
        <property type="gene ID" value="VAB18032_19350"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19350"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1293157_0_0_11"/>
    <dbReference type="OMA" id="GYWVKID"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="82"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB44972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="213" mass="23102" checksum="88E5CA77BA94B7D2" modified="2011-06-28" version="1">MTTGHPRSHRRRRRRLPWLLLVVGLLGVLGAVAYVVVPQVLPPGPRPLFQMPVGCGETWQVGTYPGHGDNDVDFFPLSGDPWGQPVLASYEGTVTVAGINGSLGGRTPENPDGPRGRGGGYWVKIDHGGRWETQYLHLLEPPMVQVGQRVAQGQQIGRIGSTGNSGAPHLHYEQRAGWQKVETWFDGQPSGITHDDAEYTVRLTSKNCAAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4FF97</accession>
    <name>F4FF97_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase/carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_19500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733657.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19500"/>
    <dbReference type="EnsemblBacteria" id="AEB45002">
        <property type="protein sequence ID" value="AEB45002"/>
        <property type="gene ID" value="VAB18032_19500"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19500"/>
    <dbReference type="eggNOG" id="COG4099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633050_0_0_11"/>
    <dbReference type="OMA" id="WVFHAED"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041172">
        <property type="entry name" value="EstA_Ig-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18435">
        <property type="entry name" value="EstA_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312987" evidence="1">
        <location>
            <begin position="25"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="EstA_Ig_like" evidence="2">
        <location>
            <begin position="37"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="433" mass="46998" checksum="A8A0482EA1D056AA" modified="2011-06-28" version="1">MRLRRALIAVAAALAIGMSGTAYAAAGDRGGAGGIASITPITTVYTYGQKVSAVAVEYPATVNPRTLDTSTFAVSDTTYNFRFNPIEDLPKLAERTITHTYTNDAPTIRADRRSVPGRYVIVELDPDENLGWTVVLSKCPTFLCHVKVNEDLPTRVVQRKDVHAQPGNGKGKGPVLVKAAPTTAHPVTEQAVNLLVDDFRYGSYLSGGMVLPYHYHLPKNYQPGRTYPLMVVLPGHGMGWDGDNLGVQIAADIPATAWLQSSWTGSTEDVIVLAPQNQRVGLPAEGDLLIRLVEQFVKDHPVDSGRVYATTVSYGSRLLWEAFAKRPDLFTAGLVTGGFQISAAQAIAIAAGEVPLWITHGVNDHLLNISLARNTHAALRAAYQAQGTSPERTAELLRYTEYGNEAFSLPDYHAAYGPTYEDSSILRWLLAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFF5</accession>
    <name>F4FFF5_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/lc7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_25795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734909.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_25795"/>
    <dbReference type="EnsemblBacteria" id="AEB46257">
        <property type="protein sequence ID" value="AEB46257"/>
        <property type="gene ID" value="VAB18032_25795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_25795"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_1_1_11"/>
    <dbReference type="OMA" id="TMVEFDD"/>
    <dbReference type="OrthoDB" id="1602136at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="140" mass="14557" checksum="6CAA56C464BDA0D1" modified="2011-06-28" version="1">MAQKTASSADLTWLLDDLVGRVKQAEHAVALSADGLLMASSQGLSRDDGEHLAAMAAGIQSLARGAGKRFGGGQVQQTIIEMQSSFLFVTAAGRNACLAVLASEDADVGLIAYEMAMLVTRVGKFVASPTRSAEQTNGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFK0</accession>
    <name>F4FFK0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_01965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736111.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_01965"/>
    <dbReference type="EnsemblBacteria" id="AEB47477">
        <property type="protein sequence ID" value="AEB47477"/>
        <property type="gene ID" value="VAB18032_01965"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_01965"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OMA" id="MITFVHA"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB47477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="277" mass="30047" checksum="8C3101146DA808A7" modified="2011-06-28" version="1">MSRLWRASPLTYFALVAAGVLSVFPIYWMFVVASRSSDAMGQLPPPVTPGGNLGANISRLFANTDAYFLTGLINSAIVAITVTISVVFFSSLAGFAFAKLRFRGSNALLMIIIATMMVPTQLGIIPLYMLMTKLNLNDRLPAVILPALVTGFGVFMMRQYAGQAISTELIEAARVDGCGTARIYWNVVLPALRPAIAVLGLLTFMTTWNDFLWPYAVLNDPENPTVQLSLRALSDGYYQDMSQVFTGTAIATLPLLLVFVLFGRQIIGGIMEGAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFQ5</accession>
    <name>F4FFQ5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_02240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736166.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_02240"/>
    <dbReference type="EnsemblBacteria" id="AEB47532">
        <property type="protein sequence ID" value="AEB47532"/>
        <property type="gene ID" value="VAB18032_02240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02240"/>
    <dbReference type="eggNOG" id="COG0578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_5_1_11"/>
    <dbReference type="OMA" id="CIVNAAG"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="32"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="428"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB47532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="605" mass="64898" checksum="7FB925267A1C0F9B" modified="2011-06-28" version="1">MRDPHVLRSVAGQLSSSRRAGDLRRLRAERFDVLIIGGGVTGAGAAVDAASRGLKVALVEARDFAAGTSSRSSKLIHGGLRYLEQLEFNLVHEALTERGLLATRLAPHLVRPVPFLVPLPAGDGVRGLPARIVRRAYYGAGVAAYDAFAGLFGGGRGMPLHRHLSREGARRIFPSLRADGLAGAIRYYDGQVDDARLVVTLARTAASLGATVVSSAQAVGLIRQAREVTGVRIRDLEAPAGSPDAEFEVQARSVIAATGVWTDDMSRMLNDVGLRPGIRVRASKGVHLVVPRSAITGDTGLILRTATSVLFVIPWGGHWIIGTTDTDWRLDRSHPAASASDIDYLLRQVNTVLDRPLTTADIEGVYAGLRPLLAGEADSTSKLSREHAVIEPMLGLLLVAGGKYTTYRVMAADVVDQAARRLGWPRPSRTADLPLLGADGYAAMWRDRADLARRHGLPVGVVEHLLERYGSLTLDLLALIDADPLLASPLAGAPEYLAAEVTYAARAEGALHLEDVLTRRTRISFETTHRGLESAEHTAELMGAVLGWDADRRAREVAHYRARVMAERQSQLMPDDATADAARLGAPDVRGYAADRGADDAGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FFV0</accession>
    <name>F4FFV0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_07030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731203.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07030"/>
    <dbReference type="EnsemblBacteria" id="AEB42530">
        <property type="protein sequence ID" value="AEB42530"/>
        <property type="gene ID" value="VAB18032_07030"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07030"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070456_1_2_11"/>
    <dbReference type="OMA" id="KREVIAM"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB42530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="255" mass="28558" checksum="8BEA665D4B7A40FE" modified="2011-06-28" version="1">MRTTAQATSWLRRYRPRPAATWRLVCFPYASGNATFYRQWAVRLPAEVEVVAVQYPGRLDRIHEPCVRDMATMVDGIVAALQPLLHTDFALFGHSMGAAVAYEVAHRLEHGLGAPPRRLIVSGRPAPQHHRPGVKHLGSDEELWDELRRLGGTTDEALAHPELRSALMPTLRADYRLVETYRPTFGAPLSVPVTAITGDDDPEAHVPEVADWRRCTTGDFQLRVLPGHHFYLIDRQAEVLDHLREALGLPAGQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4FG12</accession>
    <name>F4FG12_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_13210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732424.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13210"/>
    <dbReference type="EnsemblBacteria" id="AEB43756">
        <property type="protein sequence ID" value="AEB43756"/>
        <property type="gene ID" value="VAB18032_13210"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13210"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513696_0_0_11"/>
    <dbReference type="OMA" id="GHPSGIK"/>
    <dbReference type="OrthoDB" id="1327219at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB43756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="659" mass="68520" checksum="8C5E3D295195A304" modified="2011-06-28" version="1">MPSGFGELTDQAHDLVSAGDLAGAQRLLADALTGADPRPAHATPELAEAASLHARVLVALGEPHSARGWAAFAYAATTGLHGRSDPRTVAAAATLAAVLHRVGSWSRAARLYQEVIIELTATDGPESLRVLAAHADLATVEYARGQCQVARDRLQDAWELHREVYGDGHPSGIKMLARLGSMQRDCGQFSEAHDNLALARELSRQHLAPDDPLTAQVAALARAAANPDHVCADNPPVSNEDPVVPAARTPPPGDTPPAPQWPIDPPESATVPPTTAPPADGPAATVSPADSPAWPTDGPAWPSGESGWPAEQDPATAHPSAEEQHPVEGYHPSHGYHPGSPPPAGAASPVPTPRQPAEGPAGPPDDWWTPPATDQHPDRDRYPDTDRDAYADTYADTARDPYSDTAPYSDTAPDPYSDRDPYAAPDPYRTDRDAYGAPDPYADESGPTAGPADPYADRSTSIPPSVVGLTGPAPQAPGVYRLRRVDEPPQSGPPSRLLPVPVRRAAPPPRQPNRMVPIVAAGVAVVLLGTAAVIAGMSRLDSGADPGAPATSGAPGSTPVTTAPQASVSPGAPPTGLALRDNRDSVTLSWEYPAGSEGPVIVSGGRAGQPPSPFADLPAGTDSFVVYGLNRSLDYCFTVAVAWSTDVVARSEQVCTDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGA7</accession>
    <name>F4FGA7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoadipate:succinyl-CoA transferase, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_19715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733700.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19715"/>
    <dbReference type="EnsemblBacteria" id="AEB45045">
        <property type="protein sequence ID" value="AEB45045"/>
        <property type="gene ID" value="VAB18032_19715"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19715"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049557_0_0_11"/>
    <dbReference type="OMA" id="QLWGITG"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB45045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="272" mass="29746" checksum="0BB7F8239434CC68" modified="2011-06-28" version="1">MAKLVSLADGVAELVRDGDTVALEGFTHLIPFAAGHEIIRQRRRDLTLVRMTPDVIYDQLIGAGCARRLVFSWGGNPGVGSLHRFRDAVQNSWPVPLELEEHSHAGMANRYVAGASGLPFAVLRGYTGTDLPRHTANIRPIECPFTGEMLTAVAALRPDVTVVHAQRADRAGNVQMWGITGVQKEAVLAARRSLVTVEEIVEHLDPVPGQVILPGWAVTAVAHVPGGAHPSYTQGYSVRDNDFYRAWDAISRERATFEEWIARHVLDVEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGF8</accession>
    <name>F4FGF8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase chain 4l</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_19970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733751.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_19970"/>
    <dbReference type="EnsemblBacteria" id="AEB45096">
        <property type="protein sequence ID" value="AEB45096"/>
        <property type="gene ID" value="VAB18032_19970"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_19970"/>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_0_2_11"/>
    <dbReference type="OMA" id="YACGIYL"/>
    <dbReference type="OrthoDB" id="2078994at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB45096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="153" mass="16273" checksum="B758D1ADCF3D0443" modified="2011-06-28" version="1">MSPNLTYVIVVGVLVAAGVTLLLERSLTRVLMGVILLGNGANLLLLTGGRAGAPPIVGSAPHEEMSDPLPQAMILTAIVITLGMTAFLLALAYRSWHLNGHDEVQDDVEDRRIMDLADRDEVPDDDVDGDDDEESPTTDERQLSTTAKGGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F4FGP0</accession>
    <name>F4FGP0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_26385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26385"/>
    <dbReference type="EnsemblBacteria" id="AEB46375">
        <property type="protein sequence ID" value="AEB46375"/>
        <property type="gene ID" value="VAB18032_26385"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26385"/>
    <dbReference type="HOGENOM" id="CLU_155307_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="136" mass="15124" checksum="EA48454E4E038BEE" modified="2011-06-28" version="1">MAVAIGPPHRPDEEVPVTLPRPANAVPVSRWRSRPATPTPGAREDGTPRVVPGVYLLTQEASPQFAKPITVRVIRELTDRNSFHGWAWIQAYVLDRNGDAVQRRELFVRPVGLRPVPPPSRSRARSRRRGTAGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F4FH00</accession>
    <name>F4FH00_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731287.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07460"/>
    <dbReference type="EnsemblBacteria" id="AEB42614">
        <property type="protein sequence ID" value="AEB42614"/>
        <property type="gene ID" value="VAB18032_07460"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07460"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852094_0_0_11"/>
    <dbReference type="OMA" id="PGLMARW"/>
    <dbReference type="OrthoDB" id="1900996at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="304" mass="32176" checksum="E6D77B6EA5B0A51E" modified="2011-06-28" version="1">MGWFLDQTLDWLTDAILACLGAIFDLITSVLLTTPKVTGLPQVQALTGRSVWIVDTVFVLAFVAAGVLVMVAGGGEQSRYTVKDLLPRLVVGFTAAHFSQLACDQLIDLANALTAAISDGGYDGDGAFTAIRTHLAAAHDRTVPLLFLVLALIITVLVVTAAFQLIGRFVALLVMTAIAPLALACHALPATDGLARLWWRAYAGCLAIPVAQAFFLTAGEQTLLDPATMLPVFGLPPDPGGTLNLLVVVVLLWTTVKIPGLMARWAGQTGRGTSTMLGAVVRVVVVQQLSRTVPGLNTLRRTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHB8</accession>
    <name>F4FHB8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_13920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732563.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_13920"/>
    <dbReference type="EnsemblBacteria" id="AEB43896">
        <property type="protein sequence ID" value="AEB43896"/>
        <property type="gene ID" value="VAB18032_13920"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_13920"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_3_11"/>
    <dbReference type="OMA" id="EKPNAGM"/>
    <dbReference type="OrthoDB" id="1033671at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB43896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="409" mass="43863" checksum="2F7BC06555A67797" modified="2011-06-28" version="1">MTTTRPIPDPLAPATLGPVRLRNRVIKSATFEGATPDALVTDRLIEYHTAVGRGGVGMTTVAYLAVAPEGRTERGQVYWRPEALPGLRRLTEAVHATGAKVSAQIGHAGPVANSRSNGLPSLAASARFNPLSMGFDRAATHDDIHRIVAAHGSAAAAAREVGFDAVEVHLGHTYLAGSFLSPKLNRRRDEFGGALANRAEFARRILAAVKEAAGDDVAVIAKLNMSDGVPGGFDLDDSIPFARMLQADGHLDALELTGGSSLLNPMFLFRGDIPLAAMAAPQPPLLRLGMKMFGRFLFRDYPYQPLYFRDLALQFRRELSMPLILLGGVTDLDGMRTAMSDGFEYVAMARALLREPDLINKIRRDATTRSRCTHCNLCAASIFTGTHCPLDTEGTTALVAAGTRPVVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHJ7</accession>
    <name>F4FHJ7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733824.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20345"/>
    <dbReference type="EnsemblBacteria" id="AEB45169">
        <property type="protein sequence ID" value="AEB45169"/>
        <property type="gene ID" value="VAB18032_20345"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20345"/>
    <dbReference type="eggNOG" id="COG2327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037729_0_0_11"/>
    <dbReference type="OMA" id="CPSMYAF"/>
    <dbReference type="OrthoDB" id="540816at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="33"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="484" mass="54790" checksum="CEAF014654E9AA3E" modified="2011-06-28" version="1">MTRILVRAGKHPATVLSHEQSLATSRLGVFGSNSGNMLFYSAVFRALSVPDAELVANSYVHERPVHLGRYIARTNEEFDRFVLPMANSYRDTFLPHLERLAKVIEKLTIPVTVVGIGAQLPYGTEFDSLPDEYKRIVTRFTRAVLDRSASIGVRGEYTARMLKYLGFGDEHVRVIGCPSMFGNGPLGPLVRKVGHLRYDSPLAISYTPKVKGVDRLVEANTDRYPNSVIVPQQHHRLALMLWGENPAKVGNKRMPIHTEHPLYENDRMRFFVDASTWVEFMAEQHFAFGTRIHGNVAAVLAGTPAVVLAHDSRTVELAEYHGIPYRLYADLPPDVDAQRLYEEADFDAFLPRQVPTFETYLRFLEHNDLEHVFQPGKENPAYDKAIASANFPGPVHTLMASDAVGRRQVMSRLRWLRQGHDGDLARPAYDFEPPFREPRGSKSLEERVTQLEKELKVQQTFLASWRGRVSRVLRMNGTSTGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHT1</accession>
    <name>F4FHT1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">VAB18032_26886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735101.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_26886"/>
    <dbReference type="EnsemblBacteria" id="AEB46450">
        <property type="protein sequence ID" value="AEB46450"/>
        <property type="gene ID" value="VAB18032_26886"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_26886"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008359_1_0_11"/>
    <dbReference type="OMA" id="GFCVHFS"/>
    <dbReference type="OrthoDB" id="1043186at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="477"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEB46450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="823" mass="88628" checksum="261D1073DDC7A15C" modified="2011-06-28" version="1">MIAHRNLGLVAAAATLLAAAPLSAIFERWTWFVQAVIAVAAVAAAAALARLGRAPLWAQVLAMLGGLVLALTWLFPSGSELLAVLPAPGTFGHFAELLTGSVHDMRSYGVKVPDTDPLLFVTVLGIGAVAVLVDVLCVGMRRPALAGLPMLAIYSVPVAVYVDSVPPLPFAIGAAGFLWLLVTDNVDRVRRFGRRFTGDGRDVDVWEASPLAAAGRRLAVLGLALAVLVPLAVPGMTVGLMNSLNSGAGSGLGGTGLGGSPGRVDLFAALSGELNQSQVTDLVKVTTTEEEPFYLRFGVADDLRADGFRVRGPNGQRATGDLPDPGGQRPGVERTQHRATVEVSRELNMPLLPFYTEPVNFSDLGNNWFYDPNLQVLFSNRDNSRGKKFSFDYVRSTYTPQALRSAQPLPADLPLRRQQTVTPDVPEVRALVAELTQDKRTEYDKVRALYDYFSEDNGFTYQLSTAEGTSGQQILDFLENKAGYCQQYAAALAWMVRDAGIPARVAFGFTNGNRRSGDTLTLTNRNLHAWTEVYFDQIGWVPFDATPTYGVPGSTRSAWAPDVDAPEETTPQTDTSDTPDDTDPTETPDRGPNQFEEGVDTGAGAGPNTPASPTSTWPWLTVAGLLALLALLAVPALRRLALRRRRGRLAPVARTLDPSTADSTTTGQPRVTVSTDPDRARADAHAAWDELIDTLVDYRVRVDPTETPRATADRLARESIGTDTDAGTAVRLLGRAEERARYARDPLTGEPLPAALRTVRSALAGQADRRTRLLATALPPSVLGRWRTAVADTSARLVTSGGQLRSRLLRFNPRRLLATRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F4FHY8</accession>
    <name>F4FHY8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_02985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736313.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AEB47681">
        <property type="protein sequence ID" value="AEB47681"/>
        <property type="gene ID" value="VAB18032_02985"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_02985"/>
    <dbReference type="eggNOG" id="ENOG5031321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2195814_0_0_11"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="108" mass="11040" checksum="F7256A1048B886A9" modified="2011-06-28" version="1">MKRFSDARTVAVVAAIAACWLLASLVAGRRQDLLGVAMALLCVLLATVAGVAVAAARQQDAAVASDPAPPLGPANAAPPGVDADTLETLGDRDAVRAMRARYRTDGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI00</accession>
    <name>F4FI00_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">VAB18032_03045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736325.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_03045"/>
    <dbReference type="EnsemblBacteria" id="AEB47693">
        <property type="protein sequence ID" value="AEB47693"/>
        <property type="gene ID" value="VAB18032_03045"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_03045"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_6_11"/>
    <dbReference type="OMA" id="HNIFTNA"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003307770" description="Peptidoglycan glycosyltransferase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="720"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="780"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AEB47693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="820" mass="87328" checksum="6D1FE2CF0CBB1061" modified="2011-06-28" version="1">MRKRDHNVLTNAASLLICGLLAGVVVAAAAFPAVAMSGLAAKAGADTFGALPGELTMARAPQISYLLASDGKTPLATMYDENRRDVKFEDISPYMRAAIIAAEDHDFYKHNGVDLNGVARAFVNNSSATNDRQGASTLTMQFVRMSIAYTATHPADVLAATEDTSARKLREMRYAIQLDKEMSKDEILERYLNLAAFGNGAYGVFAASQVYFNKKPKDLTIDEAAMLAGLVKAPTSFDPTTKSGYPQAVARRDYVIDHMVTTGAITKEQAEKAKAVKLVVKGKRAPNGCVATNKNAWGFFCDYFYRWWMSQETFGATSYDRERRLKSGGYTIVTTLDKQAQDGADKAVRAAKPVTAKEAVMIAVIEPGTGRVRALSVNRNFKLDNPKNPKNRPHSDPVQRAKGKLGNYPNTVNPLLTGGDGITGYQAGSVFKIFTIVAALEKGIPLSYTINAPQQFKSEYILRQGAPATCPGTHFYCPTNSNKQPGGVKDMWSAFSASTNTYFVPLQQQIGAANVVDAAKRLGIQFRVTKENDWANDKTAANQWGAFTLGVTDTTPLELANAYATLAADGKYCEPTPVQEIRDLNGNKLDVANPRCEKRISTEVARAAVDAARCPVGDNSSTSKCGGSRTAAEGRWIVGKPIAGKSGTTDAEKSASLVAMTKQYAVAGILADPDWPQTNVKMKHKPADGINPPVFQTLKAAMAGKKAINFDPPGQKIALGDQRSIPGVRCLSIDQAKSRLSGAGFTPIVSSARVTSDCPAGSAAGTSPEGRTIKGGIVTITVSAGGGGNNDDDDDDNGRPGNGRPGNGPPTRPGTDRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4FI26</accession>
    <name>F4FI26_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_30134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pVMKU</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AB-18-032</strain>
            <plasmid evidence="3 4">pVMKU</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002639">
        <property type="protein sequence ID" value="AEB47990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013713112.1">
        <property type="nucleotide sequence ID" value="NC_015409.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_30134"/>
    <dbReference type="EnsemblBacteria" id="AEB47990">
        <property type="protein sequence ID" value="AEB47990"/>
        <property type="gene ID" value="VAB18032_30134"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_30134"/>
    <dbReference type="eggNOG" id="ENOG5032A01">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760267_0_0_11"/>
    <dbReference type="OMA" id="CAFARCK"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Plasmid pVMKU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB47990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="356" mass="38466" checksum="68498BEAEEEFC903" modified="2011-06-28" version="1">MTETITEPGVASVLRCRYSVCGAELAYSGRGRPPEYCPDRRWEPGGRTCKQMAAAERQAELAAGLDVPLAAYRAATDRVLPAVEALSSELSTVVETMRAIDGSALARIEQAEAAAVAAVERAQTAEADRDRAVRDAGTARAETAAATEARRAAERRARDAEAEAERQTTEAWRRVVDAERAHGRAEAAAAERAQAVITETQRREAAEARAADLADQLKALRRQLTDAQAETRDANKARAAAEQRADRAEAAVLAVTAERDAGRADIDRLATELKAVRTALADSEAARRQAADDLRTERAALTDARRQIDELHTSRRTAEHAAQEARVEAVRQETAARAATDRANQLQGELDQLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F125</accession>
    <name>F4F125_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_07795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731352.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07795"/>
    <dbReference type="EnsemblBacteria" id="AEB42679">
        <property type="protein sequence ID" value="AEB42679"/>
        <property type="gene ID" value="VAB18032_07795"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07795"/>
    <dbReference type="eggNOG" id="ENOG50341R3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181478_0_0_11"/>
    <dbReference type="OMA" id="SISTEWR"/>
    <dbReference type="OrthoDB" id="1924624at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="99" mass="10397" checksum="BB3D166882321F4D" modified="2011-06-28" version="1">MAPTPPTDAELNVLIRARLAALGIDLDQLSPGTTPDPETGSPGRDSVLASLRSFMRGTVAGLAAYQLPAAGNTDPRLAAALSQQRVPILYPATSTEWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4F129</accession>
    <name>F4F129_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase factor sigma-70</fullName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">VAB18032_07825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07825"/>
    <dbReference type="EnsemblBacteria" id="AEB42683">
        <property type="protein sequence ID" value="AEB42683"/>
        <property type="gene ID" value="VAB18032_07825"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07825"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043648_0_0_11"/>
    <dbReference type="OMA" id="RELHAHC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="141"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="217"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB42683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="349" mass="39073" checksum="4DB8420DCF17F173" modified="2011-06-28" version="1">MRESAVSQLLVAARAGDGDSFGRLVGPLRDELRAYCYRMLGSVHDAEDVVQDTLDRAWRSLDRFEDHGSIRPWLYKIATNRVLTVIERRGRRRELPTDMSPEGVPPAEAAWLEPYPDRLMGWTERLSPEARVVARESVELAFVAALQHLSASQRAVLLLRDVLGYSASEVADVLDTTVAAVNSALQRARRVVVERRAEPSQQQTLRMLGDAAQREVAQRYMTAWEAGDVDAIVAMLTEDARYSMPPLATWYVGRVGIRGFLVDTVLRHRWRFLPVRANGQLAFGTYLWSDERGGYVPAGLDLLALRGRQVAEVVSFLDADFPTFGLPDQLAGSDTRARDEFADRPGLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F4F150</accession>
    <name>F4F150_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_07930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731377.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_07930"/>
    <dbReference type="EnsemblBacteria" id="AEB42704">
        <property type="protein sequence ID" value="AEB42704"/>
        <property type="gene ID" value="VAB18032_07930"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_07930"/>
    <dbReference type="eggNOG" id="ENOG5030WB5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234224_0_0_11"/>
    <dbReference type="OMA" id="RMSAKHW"/>
    <dbReference type="OrthoDB" id="1325193at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB42704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="231" mass="24742" checksum="3AE96C8963A88C88" modified="2011-06-28" version="1">MSVQRPRVEVVTYDGLPAASGGAHGLRVRKPRLAWQAVQSFVDACVDPVGDPALALRLWKGGPPDVSEPLRQFAAATLGGPRTQDRTSTAWRVRPDAVDHVLGAIEDAGVAAVTEHGHPLASLVWDAEVRLLDARTGQPYDGVSPQMCGGFAVDGYGRLLGASGVRASVGTTASSLSLWLSLPGDERLAEAARRIQAHLAVRMSAKHWRRWRLTRDGSSYRSTRIPSPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1B4</accession>
    <name>F4F1B4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase, sigma 28 subunit, sig b/f/g subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_14190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732617.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14190"/>
    <dbReference type="EnsemblBacteria" id="AEB43950">
        <property type="protein sequence ID" value="AEB43950"/>
        <property type="gene ID" value="VAB18032_14190"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14190"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_5_11"/>
    <dbReference type="OMA" id="RTWDIRV"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="218"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB43950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="273" mass="29538" checksum="80219E2D22C0DA08" modified="2011-06-28" version="1">MTAPTITEPATAPTTATKLDPRALTDSATDLLNAMAALPAGHPSRAALRDRAIEAWLPLANHLAHRYSGRGEPTDDLAQTAAVGLIKAIDKFDPTRGVDFAGYAIPTIIGELKRHFRDRTWDIRVPRRLQELRLAISDANSSLLQTLGRSPTVADIAAHLKLTEEEVLEGLEGARAYNAVSLSTPTGDGDRATELGDMLGGEDSEFELAELRVALGPALATLDEREQKILTLRFYGNLTQSQIAEQIGVSQMHVSRLLARALTKLRGQLDGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1F4</accession>
    <name>F4F1F4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase, recq family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">VAB18032_14390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB43990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14390"/>
    <dbReference type="EnsemblBacteria" id="AEB43990">
        <property type="protein sequence ID" value="AEB43990"/>
        <property type="gene ID" value="VAB18032_14390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14390"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_7_11"/>
    <dbReference type="OMA" id="YAETTGC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021938">
        <property type="entry name" value="DUF3553"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12073">
        <property type="entry name" value="DUF3553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="219"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEB43990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="536" mass="58548" checksum="99C55DFAC62F7FCC" modified="2011-06-28" version="1">MSLRRAARSLFGWSTLRPNQLAAMRAVMKRRDALVVLPTGAGKSAIYQIPASLIPGPTVVISPLLALQQDQIAALNERQRPELRAVRISSDEAPSQQAEAIAEIRDGRAEFLFITPEQLANPQRLAEVRDLKPALVAIDEAHCISAWGHDFRPDYLALGQLIEGIGRPPVVALTATASPPVREDIVARLRLRNPEIVVSGLDRPNLFFEVAHCPTEDYRWRRLIALLEQDERPGIIYVPTRRAAEELAERLTAAGFPAQYYHGGMAGGARARLHEAFLADQVPIMVATSAFGMGIDKPNIAWVVHMALPDSPDSYFQEIGRAGRDGQPARVLLLWQAEDVGLQRYFSGGLPDVTELRDLAALLRSGPTTRKELRETTGLGPRKLGQYLALLEQVGAAQPRAGQRVGAPRYSPTPVQAAEAALAEAERQQNLTRSRTDMMRAFAETNACRGQTLLAYFGEQMSAICGHCDNCHAGTSVADDGAVGPFPVHSQVRHPEWGAGLVLSYEEGRMTVLFDEVGYKTLSVSVVSEQGLLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F1N2</accession>
    <name>F4F1N2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_20805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013733915.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_20805"/>
    <dbReference type="EnsemblBacteria" id="AEB45261">
        <property type="protein sequence ID" value="AEB45261"/>
        <property type="gene ID" value="VAB18032_20805"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_20805"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053650_0_0_11"/>
    <dbReference type="OMA" id="NPQTRAH"/>
    <dbReference type="OrthoDB" id="1677723at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB45261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="249" mass="26810" checksum="9751F1AEB8DBAB03" modified="2011-06-28" version="1">MNEPAASTPSGAGRAQPLMSIGEVLAQLRVDFPDVTISKLRFLEAEGLVEPQRTAAGYRKYGWDDVARLRFVLTAQRDQYLPLRVIREQLAGWEATGEVPERSRPALVAVGPDGEVPGRGAAPESAQVRLGRSELVSRSGIDESTLGELERLGLVVSDPPGWYDGDALIIAKAVAGLSAYGFQPRHLRGYRTAADREVGLFAQLVAPLVRQSDPAARARAAETARELVGLSQQLHAALVRVGLRSTLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2J5</accession>
    <name>F4F2J5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_14775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732734.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_14775"/>
    <dbReference type="EnsemblBacteria" id="AEB44067">
        <property type="protein sequence ID" value="AEB44067"/>
        <property type="gene ID" value="VAB18032_14775"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_14775"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008041_0_0_11"/>
    <dbReference type="OMA" id="MMQGANA"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PTHR21325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003312631" description="SGNH_hydro domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="4">
        <location>
            <begin position="39"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="276" mass="29381" checksum="CFF56640A310019D" modified="2011-06-28" version="1">MTLVRRALATLAGVTALVLFATGPAVADPGPPPNSMASLGDSITRGFNACGWYVDCTGRSFSTGDDTTVNSHYLRIRRVNSAINGRNHNAARTGAKSADLYGQAGTAVSQGVGYVTVLIGANDACTSSESTMTSTATFRANIDSALTRLKSGLPNAKVYVISIPDVHRLWSVGKDSSSARTAWSLFGICQSILANPTSTAQADVDRRNRVRQRVVDFNAQLAAACTAYGANCRYDNNAVFSYPFTLAQLSTWDYFHPNTTGQQALATISYPAGYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2T5</accession>
    <name>F4F2T5_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ordered locus">VAB18032_27366</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735196.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27366"/>
    <dbReference type="EnsemblBacteria" id="AEB46546">
        <property type="protein sequence ID" value="AEB46546"/>
        <property type="gene ID" value="VAB18032_27366"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27366"/>
    <dbReference type="eggNOG" id="COG0368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057426_0_1_11"/>
    <dbReference type="OMA" id="GHTGDTY"/>
    <dbReference type="OrthoDB" id="1996371at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AEB46546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="257" mass="25303" checksum="E8367E991CCFA5B9" modified="2011-06-28" version="1">MPADRRLGAGARLALTTFTVAPVRPGRVDRATAGTAMALAPLVGALLAVPVAGVLLLLDSLTAPLVAAAVAVTVSALLTRGLHLDGLADTVDALGSYRRGPAALEIMKKPDVGPFGVVALVLVLLMQVAALAELVDGPGSAVLAAVVTASAAGRLGVTLACRRGVPAARPEGLGALVAGTVGPVALAAGIAAVMLLAVPAVPDRPWQGPLAVLTALAVAAALLRHVVRRLGGITGDVLGAGVELVTTLVYLGLVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2W8</accession>
    <name>F4F2W8_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">panB</name>
        <name evidence="9" type="ordered locus">VAB18032_27531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735229.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27531"/>
    <dbReference type="EnsemblBacteria" id="AEB46579">
        <property type="protein sequence ID" value="AEB46579"/>
        <property type="gene ID" value="VAB18032_27531"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27531"/>
    <dbReference type="eggNOG" id="COG0413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_11"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="916845at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEB46579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="281" mass="29711" checksum="2D529DF0DE799D2A" modified="2011-06-28" version="1">MVESTPAEVTALYGGPATRRVRTRDLIAAKERGEKWAMLTSYDQYTASIFDAAGIPVLLVGDSAANNVFGYETTLPVTAEELLPLVRAVVRATRQTLVVGDLPFGSYEEGPTQALRTAVRFMKEGGCHAVKLEGGRRCADQIAAIVGAGIPVMAHIGFTPQSEHNLGGYRVQGRGDAAEEVVADARAVAEAGAFAVVLEMVPGAVAKRITGELSIPTVGIGAGPETDAQVLVWQDMAGLRTGRAPRFVKRYADLAGALGEATRRFADEVRGGEFPAAEHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2X1</accession>
    <name>F4F2X1_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease ii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_27546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735232.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27546"/>
    <dbReference type="EnsemblBacteria" id="AEB46582">
        <property type="protein sequence ID" value="AEB46582"/>
        <property type="gene ID" value="VAB18032_27546"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27546"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038135_1_0_11"/>
    <dbReference type="OMA" id="WNAQISL"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040596">
        <property type="entry name" value="RNase_II_C_S1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18614">
        <property type="entry name" value="RNase_II_C_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="45"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB46582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="475" mass="50452" checksum="023800687DE971F1" modified="2011-06-28" version="1">MVIRRVLAPRIDFGALRRELGLPDDYPQEARREADEAAAAPPRPAVDRTDIPLVTVDPPGSRDLDQAMHLSRRAGGGFRVRYAIADVAAHVRPGGALEEETWQRGQTVYLPDGNVPLHPHSLGEGAASLLPDVDRAAVLWTIDLDADGATTAVRLERALVRSRAQLDYPTVQVDADAGRLPEPIALLPEIGALLTTRGLRRGAINLPIPEQDVEADGDGWRLVLRAPVPMEEHNAQISLLTGMAAADLMLAGGIGLLRTMPAPKPEAVQRLRAAAAPLGVHWPDEVSVGELLLGLDPGQPRDAAFVDQAAELMRSAAYTAFDGELPEQSTHGGVAAAYAHVTAPLRRLADRYATEVCLALHDGRAVPDWARAALPRLPAAMAATDRVASTASRGAIDLAEAVLLQHRVGQTFDAAVLDVTAPSNGRGNRPPGGTVALDDPPVRARCLGELTLGTRVRVRLVTADAATRSVAFELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F4F2Y8</accession>
    <name>F4F2Y8_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_27631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_27631"/>
    <dbReference type="EnsemblBacteria" id="AEB46599">
        <property type="protein sequence ID" value="AEB46599"/>
        <property type="gene ID" value="VAB18032_27631"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_27631"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033540_1_0_11"/>
    <dbReference type="OMA" id="ERRAHHY"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="391" mass="42557" checksum="1F7449C9DB243FEF" modified="2011-06-28" version="1">MSQQVFADRLGKSKSWVDKIERGVRRLDKFSVLYEIADILQMDVQLLLGKDPERRGDTLNCIEQFEVEEIRAALERYDSVSAYFDAAPCPPPLADMSKAVTHAWLTYQYGRYGMLIRALPKLLRDAQAADAAYGGDQAERAAHLLAQVYQIASSVLRKLGECELAWLAADRSIAVAQRADDLLLAGVATTRVCNALASMGRSRPALELNVRIANRLAPGGQNDTSPERISVYGMLLLQGAMAAARIGDAATVDDLIAGAYAAAQELGSDQNHYWTSFGPTNVELHRAAAAVELGDGGRAVEVHQLKLQNPSFDALLPERRAHHLLDLARAYALIGDVANAGEMLLRGDRLAPSEIRCRPIAHEVMSDVLRRTRGAPPSLIAELAEHMGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3F0</accession>
    <name>F4F3F0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_08780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731545.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08780"/>
    <dbReference type="EnsemblBacteria" id="AEB42874">
        <property type="protein sequence ID" value="AEB42874"/>
        <property type="gene ID" value="VAB18032_08780"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08780"/>
    <dbReference type="eggNOG" id="ENOG5032S7P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061970_2_0_11"/>
    <dbReference type="OMA" id="WIVNRLA"/>
    <dbReference type="OrthoDB" id="2033191at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB42874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="310" mass="33516" checksum="B7A38B9C8A2D528B" modified="2011-06-28" version="1">MPEPAPDLVEELYRTPPDRFVAARDAAVAQARQAGDPRTAREIARLRRPTVAAWLVNLLALDRPELVADLVQLADALRTAQRELRGPRLRELSAQRRAVVGALVAEVRRLAADVEGAPSSGKLPLAEVEATLNAALSDVQVAEQVRSGRLLRAIHYAGFGEVPRPQLRLVTGAEEPPSAAPARQQPTQRGALRAEQAQRAARAERERRRRALDKELTRARTDQDRAEDELAGAAAAERDGAAALDRLEAELAELERRRAVAEQELSRARLARRAAERAAGAARRRTGEVEAAVEALEAEEDAGSGGGTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3G0</accession>
    <name>F4F3G0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine exporter protein LysE/YggA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">VAB18032_08830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731555.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08830"/>
    <dbReference type="EnsemblBacteria" id="AEB42884">
        <property type="protein sequence ID" value="AEB42884"/>
        <property type="gene ID" value="VAB18032_08830"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08830"/>
    <dbReference type="eggNOG" id="COG1279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087840_0_0_11"/>
    <dbReference type="OMA" id="FARPRAW"/>
    <dbReference type="OrthoDB" id="1953934at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AEB42884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="198" mass="20534" checksum="08AC384E653B071A" modified="2011-06-28" version="1">MLTSAVAGFSLSIALIVAIGAQNAFVLRQGLRREHLVPVVLTCAVSDALLIGVGIAGVGSVVAARPDLLTAIRWGGAAFLLGYAVLAARRALRPGALTPAQRPPARLGATLAACLAFTYLNPHVYLDTVLLLGGIAQQHQHRWWFGVGAALASVCWFTALGAGAYRLAPLLARTRVWQVLDGLIAVVMVGVAAALVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F4F3N7</accession>
    <name>F4F3N7_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ordered locus">VAB18032_15165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732810.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15165"/>
    <dbReference type="EnsemblBacteria" id="AEB44145">
        <property type="protein sequence ID" value="AEB44145"/>
        <property type="gene ID" value="VAB18032_15165"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15165"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_0_11"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB44145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="130" mass="14490" checksum="094FD486F6DB5179" modified="2011-06-28" version="1">MARVKRAVNAQKKRRTLLETASGYRGQRSRLYRKAKEQVLHSMQYAYRDRRDRKGDFRQLWIQRINAGARANGMTYNRLIQGLRLAGIEVDRKILADMAVNDAAAFAAIVELARAAVQAEGTGGAAAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4B7</accession>
    <name>F4F4B7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">VAB18032_04240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04240"/>
    <dbReference type="EnsemblBacteria" id="AEB47930">
        <property type="protein sequence ID" value="AEB47930"/>
        <property type="gene ID" value="VAB18032_04240"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04240"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034641_2_0_11"/>
    <dbReference type="OMA" id="HHLVWVI"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB47930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="448" mass="48408" checksum="983072E34568B92F" modified="2011-06-28" version="1">MAAVAYAAWLAIGAFGRPYNFFDMKIYHGAVVWWASGHELYEFVAPDTTLGFTYPPFAGLAMLPMAHLPVTMAGLVNALMSIAALAVVLAALLRPIVDRMGWPLWYTVAIATPLATAIEPVRETLGYGQVNLLLFALIMADMVALRWRSRRGTHQADTDGPLLRFIYSGAWAGVGIGLATAVKLTPALFIFYLIITRQWRVAWTAIGTTVGVTIGSFGIVGAESRAYFGSVLWQTERVGAADMTPNQSLAGLLARLYDSIETPGLLWLAFAVLVLTLGLSRAANAHSDGDELTAFTLVGLTANVISPISWTHHLVWVIPAIIVLADAAIRRRDASRGLVARATAGPYGGPPAVAALRPPIWYPTLTGIRHGIAAVGLYLLFLISPIWPYEHQLPEVSHYADGLFGAVMENSLILALIVLVAALPWRPGAEPAFLTDRMARNAILYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4E1</accession>
    <name>F4F4E1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">VAB18032_08905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731570.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_08905"/>
    <dbReference type="EnsemblBacteria" id="AEB42899">
        <property type="protein sequence ID" value="AEB42899"/>
        <property type="gene ID" value="VAB18032_08905"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_08905"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OMA" id="LMYTAKA"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="14"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEB42899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="759" mass="78693" checksum="12769B9D7635B9EC" modified="2011-06-28" version="1">MSDASASQLVADRYRLISPLGQGGMGRVWKARDEVLHRDVAIKELVPPPGLTNDERREMRERSLREARAIARLNNVNVVRIFDVLRTDGDPWIVMEYVASRSLQDTLAEDGPVSSAQAVEIGLGVLNALKAAHKAGIMHRDVKPGNVLLGTDGRVVLTDFGLATIPGDPNVTRTGMVLGSPAYIAPERARDGTAGPEADLWSLGATLYAAVEGKSPFARPSAIATLAALATEPVPPPRNAGPLKSVLTGLLRKDPQERITAESAERMLRKASGRRARSISLLGGARRPGPNGPREPRPPLVPAPRPSGERPTTPSAPVSPPAPRTPPVSGPLAAAGAVGSSLSSDAAPTAKVPADAAPTSRADAAVGSDAAQPAGSDAAPTVLVSGADSPVDGGEAAGTNNDAGASRSADAASVTAGGGAESGLDADSGATAGAGETDQSGAAVPGGAAADTGAEPTAKVDRSTSTMDRATAHPDTDATRRVDPAPAGEHTRVVPQRTSLMPSVPDDPTPARGSVFTSGFLRSERNRRGLLVGALVALLLVGLVVAVPLLTGDDGGDDGTSPGAASSSGTPTAATSEPAAPPPTSAAPPTSAAPPSPSATPSTAPPTNGALPEGWTLRNDPVGFKVAVPEGWRRSAGGTWVKYRDPNGVSELTIDRTDSPGRDAAATWRQLEPGRKNVRGVQNYRLIDIWSFDCKWRTCGDWDWKQTRNGVEIRVRNRGFVTASNRGFALRWEVPNSEWEAQLPNFETAFREFVPDRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4R1</accession>
    <name>F4F4R1_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">VAB18032_15455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732868.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15455"/>
    <dbReference type="EnsemblBacteria" id="AEB44203">
        <property type="protein sequence ID" value="AEB44203"/>
        <property type="gene ID" value="VAB18032_15455"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15455"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_11"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEB44203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="256" mass="27968" checksum="7305557E776D8C01" modified="2011-06-28" version="1">MPRDNRTPSPDAPVYTGPERLQKVLAAAGVGSRRACEDLIFRRKVTVNGRVAQLGDKVDPATAVIHVNGERLQADTRLVYLAMNKPRGVVSTMADERGRTALADFLNNRVEQRVYHVGRLDADSEGLLLLTNDGTLAHRLMHPSYGVQKTYLCEVAGPIPRNLGKRLAAGIELEDGPVSVDAFRVVDSLGRTAQVELSLHEGRKHIVRRLLAEVGHPVSRLVRTAIGPIRLGDLRSGRTRRLTNAEVAALFKAVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F4R9</accession>
    <name>F4F4R9_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TraB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_15495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15495"/>
    <dbReference type="EnsemblBacteria" id="AEB44211">
        <property type="protein sequence ID" value="AEB44211"/>
        <property type="gene ID" value="VAB18032_15495"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15495"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430636_0_0_11"/>
    <dbReference type="OMA" id="NRRPGYC"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB44211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="641" mass="67882" checksum="F7283DD2E79FBF26" modified="2011-06-28" version="1">MPRHGGLSPMSYSVDLRSAALPYLVCPTGCLLAWPVAAASHHWWGSNPWAAAGLTAAGGGLTALTWFAGRARGVIRQRIATLLTASGSLWMLGATIAAPWERPWLDLWAGGTLTASVAVAVMRLMAKANPDEQATRTTGGGLADAVAALKDARIGRPTVDGAKVKANVAMPHGDTLADVEGSRDAIASALDVAPSAVRVHRDPDSVRTGRIEVVPVDQLRHTIAWGGPSAPGRSVGDAPLRFGVAEDGEQVGLWLTGRPGVRPATHVRATGMTGSGKTEWALVVMTDYLTRADGALVVVDTVKRDQTVKPVKDGLTLLVTEDEHAEAFFDILAEKVIPARTEALGREDLTEWMPGCSLSHLLVWVEESAAWSGHPALVQVAERARSAGISLVLSQQRWTHDRAPTSLRSQFATNVCFGIDSRDDPSLALSGETVDAGASPETWGSSKPGYLYIESPGIPTGRWPIPCRSELAQRGDLAAAVTGWAQVRQPLDPVTARALAPVMPTTAKPSPGPRPTAHGDGGRDQEVPAMAARPGVNPHDPPDNVDPAQELDTTPTPRRFSLALPQQSSPEQARVILREHIAALAAQGETEVRPADLGDVLAATGYTAKWLSKALAELTTGNQPLLMAINRNGRYRILRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F4F522</accession>
    <name>F4F522_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">VAB18032_28166</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AB-18-032</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735354.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28166"/>
    <dbReference type="EnsemblBacteria" id="AEB46704">
        <property type="protein sequence ID" value="AEB46704"/>
        <property type="gene ID" value="VAB18032_28166"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28166"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_11"/>
    <dbReference type="OMA" id="HFFHEVG"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="67"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="300"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="426"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="540"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="854"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="790"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AEB46704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="902" mass="97302" checksum="9D89FD09DB2FE574" modified="2011-06-28" version="1">MAAQETVEHKYVYDFAEGNKDLKDLLGGKGANLAEMTNLGLPVPPGFTITTEACQAYLASGEQPAGLADQIAAHLAALEQGMGRRLGDPDDPLLVSVRSGAKFSMPGMMETVLNVGLNDRSVVGLAAQANGNQRFAWDSYRRLIQMFGKTVCEVPGEEFEHAIDEAKRAKGSTDDLDLDADDLRALVDTYKKIFSKHTGREFPQDPREQLDLAIGAVFDSWNAERAVIYRRQERIPADLGTAVNVVAMVFGNLGPDSGTGVAFTRDPASGAQGIYGDYLANAQGEDVVAGIRNTVPLQELERINKAAYDELLDYMARLERHYKDLCDIEFTIERGKLWMLQTRVGKRTAAAAFVIAGQLVDEGLIDLDEALHRVNGAQLAQLMFPRFQLDHGFEAVATGIGASPGAAVGKVVFTSARAVELAGQGEDVILVRRETNPDDLNGMIASRGILTSRGGKTSHAAVVARGMGKTCVSGADALDIDVPKRRFTVAGQTVTEGDVVSIDGTTGKVYLGEVPATPSEVVQYFEGELDPEATDDALVRAVHRIMSHADATRRLTVRTNADTAADAARARRFGAQGIGLCRTEHMFLGDRRELVERLILARDANERDESLAALLPLQRADFVEIFRAMDGQPVTVRLIDPPLHEFLPPLEQLAVDVAVAQERGEDVAKEEALLAAVRRMHEENPMLGLRGVRLGLVIPGLFAMQVRAITEAAVECTRQGVRACPEIMVPLVGAVQELETVRTEAEKIIAEVVGGSDVEVLIGTMIEVPRAALTAGQIAEAAEFFSFGTNDLTQMGWGFSRDDVEGAFFWRYLELGIFGISPFESIDADGIGRLVRIAAEEGRAARPGLKLGVCGEHGGDPDSVHFFHSVGLDYVSCSPFRVPVARLEAGRAAVVTAGSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F4F555</accession>
    <name>F4F555_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">VAB18032_28331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AB-18-032</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735387.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28331"/>
    <dbReference type="EnsemblBacteria" id="AEB46737">
        <property type="protein sequence ID" value="AEB46737"/>
        <property type="gene ID" value="VAB18032_28331"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28331"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_2_11"/>
    <dbReference type="OMA" id="TIGRQHP"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="10"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="284"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AEB46737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="460" mass="48902" checksum="8F0C0FFF868A6719" modified="2011-06-28" version="1">MDTSLAASATGLPDLQLLAFAAGLVVLGGLIAMTEAALAAVSPARAAELAREGARGAPTLQLVAGDVVRHLNLLLLLRLLAELTATTLVALVAVDTFGAGWRAALVTAGAMTVVSFVVVGVGPRTIGRQHAYAVARFAAPLVRWLGRALNPLASLLILIGNAVTPGRGFREGPFATQVELRELVDLAEQRGVVEHGERQMIHSVFALGDTIAREVMVPRTEMVWIESTKTLAQALALFLRSGFSRIPVIGESVDDVLGVLYLKDLIRRTQGGAAEDRQLPVAELMRPATFVPDSKPVDDLLSEMQAARNHLVIVVDEYGGTGGLVTIEDILEEIVGEITDEYDVERPPIEQLPDGAVRVTARLPVEDLGELFDTELPHDEVETVGGLLAQCLGRVPIPGAEVEVAGLQLLAEGTTGRRNRIDTVLVRRVEPTDTQDNPGGGPTASRGDTDRSEERQPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F4F563</accession>
    <name>F4F563_MICM1</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hrcA</name>
        <name evidence="8" type="ordered locus">VAB18032_28371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AB-18-032</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28371"/>
    <dbReference type="EnsemblBacteria" id="AEB46745">
        <property type="protein sequence ID" value="AEB46745"/>
        <property type="gene ID" value="VAB18032_28371"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28371"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050019_2_0_11"/>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="116"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEB46745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="352" mass="38674" checksum="EDDCF567CB851F6C" modified="2011-06-28" version="1">MTLDTDLRQEVEMGLDDRKLAVLRAIVEDYVATQEPVGSKALVERHQLGVSPATVRNDMAVLEEEGYIRQPHTSAGRVPTDRGYRLFVDRLSRVKPLSPAERRAIERFLAGAVDLDDVVHRTVRLLAQLTRQVAVVQYPSLARSRVRHLELVPISTTRLMLVVIADTGRVEQRLVELPAPIHADDVLDLRRTVNEKLVGIQLSETPPLVQTLIDECVPHLRGAMTTLSTVLLETLVERHEERIALAGTANLARGGLLDFQGSLRPILEALEEEVVLLKLIGEVEPSTLRVRIGDENEIDNLRAASVVSTGYGPGATIVGGMGVLGPTRMDYPGTIATVRAVARYVGELLAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5B2</accession>
    <name>F4F5B2_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_04390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB47960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013736591.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_04390"/>
    <dbReference type="EnsemblBacteria" id="AEB47960">
        <property type="protein sequence ID" value="AEB47960"/>
        <property type="gene ID" value="VAB18032_04390"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_04390"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836295_0_0_11"/>
    <dbReference type="OMA" id="KSIPGDM"/>
    <dbReference type="OrthoDB" id="1941916at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB47960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="357" mass="37352" checksum="A7E6C87E93D1F9B1" modified="2011-06-28" version="1">MTAGEFSEVDHDLLADYLGGALEGTPEQAEVARLIAQDPSWAQAHALLAPAVAEVRTDLLGWGGSAVEMPPEVADRIRAALDTADLSDVLPDSDDTDLDSDIPATASDHSDDRVSTGRPSRVPAQPLGGRRPQAAPPSGPDRNATRPGPDRNATRPGRRSRRWARIAGPVALAAALVVGLGSLQLVRPNQGGDTTAGTALSDPVATPHVQEGQAGPERAAVNASPQRLPVTEGTPQRHTGRDYTPQELATEPEAKISAYSSTETPDAGGDVDRMAGPADLARLDDQVALTACLADIGTEHGAQPLVFEDIEYARFQGHPALVVRFTDAAGTRWAWVSGPECGIPGSGSDSRHRTRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5G0</accession>
    <name>F4F5G0_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_09370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB42992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013731663.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_09370"/>
    <dbReference type="EnsemblBacteria" id="AEB42992">
        <property type="protein sequence ID" value="AEB42992"/>
        <property type="gene ID" value="VAB18032_09370"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_09370"/>
    <dbReference type="eggNOG" id="ENOG5033HJ6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167344_0_0_11"/>
    <dbReference type="OMA" id="ANRHQQH"/>
    <dbReference type="OrthoDB" id="2033649at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB42992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="97" mass="10368" checksum="20F344D4449859E8" modified="2011-06-28" version="1">MLTAVQVLAQNNFGDTRTGGLAGPMGLFLILVLGAATVLLIRNMNARLRRLPDEFPAQQPEARRDAAGRMVSDPTDGTVTADSSADAANRHQQHRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5R7</accession>
    <name>F4F5R7_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">VAB18032_15850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB44280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013732944.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_15850"/>
    <dbReference type="EnsemblBacteria" id="AEB44280">
        <property type="protein sequence ID" value="AEB44280"/>
        <property type="gene ID" value="VAB18032_15850"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_15850"/>
    <dbReference type="eggNOG" id="ENOG5031UD4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2182840_0_0_11"/>
    <dbReference type="OrthoDB" id="2068891at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEB44280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="109" mass="12539" checksum="6AE32AF4C8C5AC87" modified="2011-06-28" version="1">MAYIQPWQRLCDCRCLVHHHRPRTTYNDPDCACTITCTTQPLTLLADPWGCALFLDHGGDLWHVPAMTHGTFDWAYAAEIDSRHDHYDASRTIEHLLRQAAHELRASIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F4F5Y4</accession>
    <name>F4F5Y4_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase involved in non-ribosomal peptide synthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">VAB18032_22215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AB-18-032</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB45543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013734196.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_22215"/>
    <dbReference type="EnsemblBacteria" id="AEB45543">
        <property type="protein sequence ID" value="AEB45543"/>
        <property type="gene ID" value="VAB18032_22215"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_22215"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070456_1_1_11"/>
    <dbReference type="OMA" id="AFFGHCA"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AEB45543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="244" mass="26738" checksum="440B0686A05DFBAA" modified="2011-06-28" version="1">MTVDAARANGWLLRPVSGDPVARLFCLPYLGAGASMYHRWPRRIGEVEVCLLQPPGRENRLLEPAHQAYEPFAEDLLAAVEPLLDRPYALFAHCNSVFAAYVVALRLAAAGHRPRRFFASSMVAPDQVPFGSLLDVPADRLPEVVADLMRARGTEPSPEIVELAMEAVESDLRAYRDFGGAAPAPMPCPVTVLSWRDDRTVPPSLTTGWTRFGQDRAVSLDGDHWAFLDPSPALLRIIAEDLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F4F626</accession>
    <name>F4F626_MICM1</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyribodipyrimidine photolyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">VAB18032_28536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL B-24793 / AB-18-032)</name>
        <name type="synonym">Verrucosispora maris</name>
        <dbReference type="NCBI Taxonomy" id="263358"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micromonosporales</taxon>
            <taxon>Micromonosporaceae</taxon>
            <taxon>Micromonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="3391" last="3392">
            <title>Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.</title>
            <authorList>
                <person name="Roh H."/>
                <person name="Uguru G.C."/>
                <person name="Ko H.J."/>
                <person name="Kim S."/>
                <person name="Kim B.Y."/>
                <person name="Goodfellow M."/>
                <person name="Bull A.T."/>
                <person name="Kim K.H."/>
                <person name="Bibb M.J."/>
                <person name="Choi I.G."/>
                <person name="Stach J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21551311"/>
            <dbReference type="DOI" id="10.1128/JB.05041-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AB-18-032</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002638">
        <property type="protein sequence ID" value="AEB46778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013735427.1">
        <property type="nucleotide sequence ID" value="NC_015434.1"/>
    </dbReference>
    <dbReference type="STRING" id="263358.VAB18032_28536"/>
    <dbReference type="EnsemblBacteria" id="AEB46778">
        <property type="protein sequence ID" value="AEB46778"/>
        <property type="gene ID" value="VAB18032_28536"/>
    </dbReference>
    <dbReference type="KEGG" id="vma:VAB18032_28536"/>
    <dbReference type="eggNOG" id="COG3046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031632_1_0_11"/>
    <dbReference type="OMA" id="GMSQYAD"/>
    <dbReference type="OrthoDB" id="215545at2"/>
    <dbReference type="Proteomes" id="UP000008308">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007357">
        <property type="entry name" value="PhrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04244">
        <property type="entry name" value="DPRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEB46778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008308"/>
        </source>
    </evidence>
    <sequence length="490" mass="56658" checksum="A5C32B7C0F206461" modified="2011-06-28" version="1">MPRRWLFADQLGPHFLDERRQPVLLIESKAVFRRRAFHRQKAHLVLSALRHRAAELGNQAIFLRAETYRQALRRVREPLEVCHPTSRAALDFVRGLDQVTVLPPRGFVTGLDEFADWADARRGALRMETFYRFAREHHRVLVDGAEPVGGRWSFDTENRQPPPKGVERLDVPPPPMPREDDIDAEVREDLDRWEREG
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